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Sample records for 6a mixed strategy

  1. Mixed Strategies in cyclic competition

    NASA Astrophysics Data System (ADS)

    Intoy, Ben; Pleimling, Michel

    2015-03-01

    Physicists have been using evolutionary game theory to model and simulate cyclically competing species, with applications to lizard mating strategies and competing bacterial strains. However these models assume that each agent plays the same strategy, which is called a pure strategy in game theory, until they are beaten by a better strategy which they immediately adopt. We relax this constraint of an agent playing a single strategy by instead letting the agent pick its strategy randomly from a probability distribution, which is called a mixed strategy in game theory. This scheme is very similar to multiple occupancy models seen in the literature, the major difference being that interactions happen between sites rather than within them. Choosing strategies out of a distribution also has applications to economic/social systems such as the public goods game. We simulate a model of mixed strategy and cylic competition on a one-dimensional lattice with three and four strategies and find interesting spatial and stability properties depending on how discretized the choice of strategy is for the agents. This work is supported by the US National Science Foundation through Grant DMR-1205309.

  2. Evolutionary stability of mixed strategies on graphs

    NASA Astrophysics Data System (ADS)

    Li, Yan; Liu, Xinsheng; Claussen, Jens Christian

    2016-07-01

    Up to the present time, the study of evolutionary dynamics mostly focused on pure strategy games in finite discrete strategy space, either in well-mixed or structured populations. In this paper, we study mixed strategy games in continuous strategy space on graphs of degree k. Each player is arranged on a vertex of the graph. The edges denote the interaction between two individuals. In the limit of weak selection, we first derive the payoff functions of two mixed strategies under three different updating rules, named birth-death, death-birth and imitation. Then we obtain the conditions for a strategy being a continuously stable strategy (CSS), and we also confirm that the equilibrium distribution corresponding to the CSS is neighborhood attracting and strongly uninvadable. Finally, we apply our theory to the prisoner’s dilemma and the snowdrift game to obtain possible CSS. Simulations are performed for the two special games and the results are well consistent with the conclusions we made.

  3. Optimal control of anthracnose using mixed strategies.

    PubMed

    Fotsa Mbogne, David Jaures; Thron, Christopher

    2015-11-01

    In this paper we propose and study a spatial diffusion model for the control of anthracnose disease in a bounded domain. The model is a generalization of the one previously developed in [15]. We use the model to simulate two different types of control strategies against anthracnose disease. Strategies that employ chemical fungicides are modeled using a continuous control function; while strategies that rely on cultivational practices (such as pruning and removal of mummified fruits) are modeled with a control function which is discrete in time (though not in space). For comparative purposes, we perform our analyses for a spatially-averaged model as well as the space-dependent diffusion model. Under weak smoothness conditions on parameters we demonstrate the well-posedness of both models by verifying existence and uniqueness of the solution for the growth inhibition rate for given initial conditions. We also show that the set [0, 1] is positively invariant. We first study control by impulsive strategies, then analyze the simultaneous use of mixed continuous and pulse strategies. In each case we specify a cost functional to be minimized, and we demonstrate the existence of optimal control strategies. In the case of pulse-only strategies, we provide explicit algorithms for finding the optimal control strategies for both the spatially-averaged model and the space-dependent model. We verify the algorithms for both models via simulation, and discuss properties of the optimal solutions.

  4. Mixed Membership Distributions with Applications to Modeling Multiple Strategy Usage

    ERIC Educational Resources Information Center

    Galyardt, April

    2012-01-01

    This dissertation examines two related questions. "How do mixed membership models work?" and "Can mixed membership be used to model how students use multiple strategies to solve problems?". Mixed membership models have been used in thousands of applications from text and image processing to genetic microarray analysis. Yet…

  5. The role of mixed strategies in spatial evolutionary games

    NASA Astrophysics Data System (ADS)

    Szabó, György; Hódsági, Kristóf

    2016-11-01

    We study three-strategy evolutionary games on a square lattice when the third strategy is a mixed strategy of the first and second ones. It is shown that the resultant three-strategy game is a potential game as well as its two-strategy version. Evaluating the potential we derive a phase diagram on a two-dimensional plane of rescaled payoff parameters that is valid in the zero noise limit of the logit dynamical rule. The mixed strategy is missing in this phase diagram. The effects of two different dynamical rules are analyzed by Monte Carlo simulations and the results of imitation dynamics indicate the dominance of the mixed strategy within the region of the hawk-dove game where it is an evolutionarily stable strategy. The effects and consequences of the different dynamical rules on the final stationary states and phase transitions are discussed.

  6. Acceleration of quantum optimal control theory algorithms with mixing strategies.

    PubMed

    Castro, Alberto; Gross, E K U

    2009-05-01

    We propose the use of mixing strategies to accelerate the convergence of the common iterative algorithms utilized in quantum optimal control theory (QOCT). We show how the nonlinear equations of QOCT can be viewed as a "fixed-point" nonlinear problem. The iterative algorithms for this class of problems may benefit from mixing strategies, as it happens, e.g., in the quest for the ground-state density in Kohn-Sham density-functional theory. We demonstrate, with some numerical examples, how the same mixing schemes utilized in this latter nonlinear problem may significantly accelerate the QOCT iterative procedures.

  7. Mixing and pragmatic parental strategies in early bilingual acquisition.

    PubMed

    Juan-Garau, M; Pérez-Vidal, C

    2001-02-01

    This paper investigates the relationship between a child's degree of bilingualism and features of parental input. It seeks to demonstrate that parental discourse strategies have a direct bearing on the levels of mixing present in the child's utterances in his weaker language, English. It is based on the longitudinal study of a Catalan/English bilingual child from 1;3 to 4;2 years old. The strategies adopted by both parents in response to their child's mixing are examined following Lanza's (1992, 1997) categorization of parental discourse strategies. Whereas the Catalan-speaking mother negotiates a bilingual context of interaction with her son, as of the child's third year, the English-speaking father endeavours to impose a monolingual context. Such a change of strategy clearly favours the child's increasing use of the minority language, which entails a sharp decline in rates of mixing. It appears that parents' pragmatic choices may have an impact on the development of productive family bilingualism.

  8. Mixing and Pragmatic Parental Strategies in Early Bilingual Acquisition.

    ERIC Educational Resources Information Center

    Juan-Garau, Maria; Perez-Vidal, Carmen

    2001-01-01

    Investigates the relationship between a child's degree of bilingualism and features of parental input. Seeks to demonstrate that parental discourse strategies have a direct bearing on the levels of mixing present in a child's utterances in his weaker language (English). (Author/VWL)

  9. Properties of a mixed ESS candidate in continuous strategy sets.

    PubMed

    Yaniv, Osnat

    2006-02-21

    An evolutionarily stable strategy (ESS) is a strategy that if almost all members of the population adopt, then this population cannot be invaded by any mutant strategy. An ESS is not necessarily a possible end point of the evolutionary process. Moreover, there are cases where the population evolves towards a strategy that is not an ESS. This paper studies the properties of a unique mixed ESS candidate in a continuous time animal conflict. A member of a group sized three finds itself at risk and needs the assistance of another group member to be saved. In this conflict, a player's strategy is to choose the probability distribution of the interval between the beginning of the game and the moment it assists the player which is at risk. We first assume that a player is only allowed to choose an exponential distribution, and show that in this case the ESS candidate is an attracting ESS; the population will always evolve towards this strategy, and once it is adopted by most members of the population it cannot be invaded by mutant strategies. Then, we extend the strategy sets and allow a player to choose any continuous distribution. We show that although this ESS candidate may no longer be an ESS, under fairly general conditions the population will tend towards it. This is done by characterizing types of strategies that if established in the population, can be invaded by this ESS candidate, and by presenting possible paths of transition from other types of common strategies to this ESS candidate.

  10. In situ vitrification of a mixed-waste contaminated soil site: The 116-B-6A crib at Hanford

    SciTech Connect

    Luey, J.; Koegler, S.S.; Kuhn, W.L.; Lowery, P.S.; Winkelman, R.G.

    1992-09-01

    The first large-scale mixed-waste test of in situ vitrification (ISV) has been completed. The large-scale test was conducted at an actual contaminated soil site, the 116-B-6A crib, on the Department of Energy's Hanford Site. The large-scale test was a demonstration of the ISV technology and not an interim action for the 116-B-6A crib. This demonstration has provided technical data to evaluate the ISV process for its potential in the final disposition of mixed-waste contaminated soil sites at Hanford. Because of the test's successful completion. technical data on the vitrified soil are available on how well the process incorporates transuranics and heavy metals into the waste form. how well the form resists leaching of transuranics and heavy metals. how well the process handles sites with high combustible loadings, and the important site parameters which may affect the achievable process depth. This report describes the 116-B-6A crib site, the objectives of the ISV demonstration, the results in terms of the objectives, and the overall process performance.

  11. Herbivores can select for mixed defensive strategies in plants.

    PubMed

    Carmona, Diego; Fornoni, Juan

    2013-01-01

    Resistance and tolerance are the most important defense mechanisms against herbivores. Initial theoretical studies considered both mechanisms functionally redundant, but more recent empirical studies suggest that these mechanisms may complement each other, favoring the presence of mixed defense patterns. However, the expectation of redundancy between tolerance and resistance remains unsupported. In this study, we tested this assumption following an ecological genetics field experiment in which the presence/absence of two herbivores (Lema daturaphila and Epitrix parvula) of Datura stramonium were manipulated. In each of three treatments, genotypic selection analyses were performed and selection patterns compared. Our results indicated that selection on resistance and tolerance was significantly different between the two folivores. Tolerance and resistance are not redundant defense strategies in D. stramonium but instead functioned as complementary defenses against both beetle species, favoring the evolution of a mixed defense strategy. Although each herbivore was selected for different defense strategies, the observed average tolerance and resistance were closer to the adaptive peak predicted against E. parvula and both beetles together. In our experimental population, natural selection imposed by herbivores can favor the evolution of mixed defense strategies in plants, accounting for the presence of intermediate levels of tolerance and resistance.

  12. Mixed strategy and coevolution dynamics in social networks

    NASA Astrophysics Data System (ADS)

    Zhong, Weicai; Abbass, Hussein A.; Bender, Axel; Liu, Jing

    2011-01-01

    We investigate coevolution dynamics of both individual strategies and social ties as they adapt within the snowdrift game with mixed strategies. We propose a partner selection mechanism based on the concept of trust. Here trust is considered an instrument for an individual both selecting the right partners and being selected amongst other potential partners. Based on her local views of the system, the focal individual dismisses the link from the partner with the lowest trust and rewires to the partner’s partner with the highest trust. It is shown that such a trust-based partner switching mechanism favors the emergence of cooperators. Furthermore, when the number of an individual’s partners is restricted (which is a metaphor of limited capacities and capabilities of an individual in real environments), surprising assortative mixing patterns are formed in the emerging network and change the network’s degree distribution from a power-law distribution to an asymmetrically U-shaped distribution. This plays a leading role in preventing global avalanches triggered by perturbations acting on the state of the highly connected individuals.

  13. Strategies for Developing an Awareness in Biotechnology for Mixed-Ability Groups in Secondary Schools.

    ERIC Educational Resources Information Center

    Kam, Goh Ah

    1984-01-01

    Explains plausible strategies for introducing biotechnology into a science curricula through a microbiology course. Teaching strategies for large mixed-ability groups are presented. Concept maps, games, activities and materials references are included. (ML)

  14. Code-Mixing as a Bilingual Instructional Strategy

    ERIC Educational Resources Information Center

    Jiang, Yih-Lin Belinda; García, Georgia Earnest; Willis, Arlette Ingram

    2014-01-01

    This study investigated code-mixing practices, specifically the use of L2 (English) in an L1 (Chinese) class in a U.S. bilingual program. Our findings indicate that the code-mixing practices made and prompted by the teacher served five pedagogical functions: (a) to enhance students' bilingualism and bilingual learning, (b) to review and…

  15. Control Strategies for HCCI Mixed-Mode Combustion

    SciTech Connect

    Wagner, Robert M; Edwards, Kevin Dean

    2010-03-01

    Delphi Automotive Systems and ORNL established this CRADA to expand the operational range of Homogenous Charge Compression Ignition (HCCI) mixed-mode combustion for gasoline en-gines. ORNL has extensive experience in the analysis, interpretation, and control of dynamic engine phenomena, and Delphi has extensive knowledge and experience in powertrain compo-nents and subsystems. The partnership of these knowledge bases was important to address criti-cal barriers associated with the realistic implementation of HCCI and enabling clean, efficient operation for the next generation of transportation engines. The foundation of this CRADA was established through the analysis of spark-assisted HCCI data from a single-cylinder research engine. This data was used to (1) establish a conceptual kinetic model to better understand and predict the development of combustion instabilities, (2) develop a low-order model framework suitable for real-time controls, and (3) provide guidance in the initial definition of engine valve strategies for achieving HCCI operation. The next phase focused on the development of a new combustion metric for real-time characterization of the combustion process. Rapid feedback on the state of the combustion process is critical to high-speed decision making for predictive control. Simultaneous to the modeling/analysis studies, Delphi was focused on the development of engine hardware and the engine management system. This included custom Delphi hardware and control systems allowing for flexible control of the valvetrain sys-tem to enable HCCI operation. The final phase of this CRADA included the demonstration of conventional and spark assisted HCCI on the multi-cylinder engine as well as the characterization of combustion instabilities, which govern the operational boundaries of this mode of combustion. ORNL and Delphi maintained strong collaboration throughout this project. Meetings were held on a bi-weekly basis with additional reports, presentation, and

  16. Visual, Algebraic and Mixed Strategies in Visually Presented Linear Programming Problems.

    ERIC Educational Resources Information Center

    Shama, Gilli; Dreyfus, Tommy

    1994-01-01

    Identified and classified solution strategies of (n=49) 10th-grade students who were presented with linear programming problems in a predominantly visual setting in the form of a computerized game. Visual strategies were developed more frequently than either algebraic or mixed strategies. Appendix includes questionnaires. (Contains 11 references.)…

  17. Mixed strategies and natural selection in resource allocation.

    PubMed

    Kareva, Irina; Berezovkaya, Faina; Karev, Georgy

    2013-01-01

    An appropriate choice of strategy for resource allocation may frequently determine whether a population will be able to survive under the conditions of severe resource limitations. Here we focus on two classes of strategies allocation of resources towards rapid proliferation, or towards slower proliferation but increased physiological and environmental maintenance. We propose a generalized framework, where individuals within a population can use either strategy in different proportion for utilization of a common dynamical resource in order to maximize their fitness. We use the model to address two major questions, namely, whether either strategy is more likely to be selected for as a result of natural selection, and, if one allows for the possibility of resource over-consumption, whether either strategy is preferable for avoiding population collapse due to resource exhaustion. Analytical and numerical results suggest that the ultimate choice of strategy is determined primarily by the initial distribution of individuals in the population, and that while investment in physiological and environmental maintenance is a preferable strategy in a homogeneous population, no generalized prediction can be made about heterogeneous populations.

  18. Strategies for characterizing mixed nuclear wastes: The challenges

    SciTech Connect

    Toste, A.P.

    1993-12-31

    The chemical analysis of nuclear wastes, especially mixed wastes, pose various problems to the analytical chemist. The chemical content may be very complex, particularly when organics are present. This report describes the analysis of two highly radioactive wastes: a neutralized cladding removal waste, and a volume reduction, double-shell slurry waste. The organic content analysis is described.

  19. Conceptual Issues and Analytic Strategies in Mixed-Method Studies of Preschool Inclusion.

    ERIC Educational Resources Information Center

    Li, Shouming; Marquart, Jules M.; Zercher, Craig

    2000-01-01

    This paper addresses the conceptual issues of combining qualitative and quantitative methods in early intervention research by illustrating how two analytic approaches were used for different mixed-method purposes in the study of preschool inclusion. It describes practical strategies for conducting mixed-method data analysis in terms of data…

  20. In situ vitrification of a mixed-waste contaminated soil site: The 116-B-6A crib at Hanford. CERCLA treatability test report

    SciTech Connect

    Luey, J; Koegler, S S; Kuhn, W L; Lowery, P S; Winkelman, R G

    1992-09-01

    The first large-scale mixed-waste test of in situ vitrification (ISV) has been completed. The large-scale test was conducted at an actual contaminated soil site, the 116-B-6A crib, on the Department of Energy`s Hanford Site. The large-scale test was a demonstration of the ISV technology and not an interim action for the 116-B-6A crib. This demonstration has provided technical data to evaluate the ISV process for its potential in the final disposition of mixed-waste contaminated soil sites at Hanford. Because of the test`s successful completion. technical data on the vitrified soil are available on how well the process incorporates transuranics and heavy metals into the waste form. how well the form resists leaching of transuranics and heavy metals. how well the process handles sites with high combustible loadings, and the important site parameters which may affect the achievable process depth. This report describes the 116-B-6A crib site, the objectives of the ISV demonstration, the results in terms of the objectives, and the overall process performance.

  1. Pedagogical Strategies Used by Selected Leading Mixed Methodologists in Mixed Research Courses

    ERIC Educational Resources Information Center

    Frels, Rebecca K.; Onwuegbuzie, Anthony J.; Leech, Nancy L.; Collins, Kathleen M. T.

    2014-01-01

    The teaching of research methods is common across multiple fields in the social and educational sciences for establishing evidence-based practices and furthering the knowledge base through scholarship. Yet, specific to mixed methods, scant information exists as to how to approach teaching complex concepts for meaningful learning experiences. Thus,…

  2. LETTER TO THE EDITOR: Mixed population Minority Game with generalized strategies

    NASA Astrophysics Data System (ADS)

    Jefferies, P.; Hart, M.; Johnson, N. F.; Hui, P. M.

    2000-11-01

    We present a quantitative theory, based on crowd effects, for the market volatility in a Minority Game played by a mixed population. Below a critical concentration of generalized strategy players, we find that the volatility in the crowded regime remains above the random coin-toss value regardless of the `temperature' controlling strategy use. Our theory yields good agreement with numerical simulations.

  3. Optimizing the mix of strategies for control of vehicular emissions

    SciTech Connect

    Lejano, R.P.; Ayala, P.M.; Gonzales, E.A.

    1997-01-01

    A number of strategies for the control of vehicular emissions are being considered by the Philippine government to address Metropolitan Manila`s air quality problem. An analytical tool is needed for optimizing criteria pollutant reductions given the budgetary constraints. The simplest approach is to take costs and pollutant removals to be linear with each strategy`s scale of activity, and this is readily solved as a linear programming problem. Another approach is to use a dynamic system of weights which shift with progressive improvements in pollutant emissions. The two approaches yield somewhat different results, suggesting the sensitivity of the solution to the assumed weights. The study also illustrates the importance of a sound methodology for evaluating priorities given to different air quality goals. One such methodology may involve a polling of expert panels and the public to gain insight into the relative importance given to competing emissions reduction goals. An informal polling of resource agency staff was conducted and discussed in this paper. The authors take the position that proper planning involves tracing intermediate steps to the final outcome and not just focusing on the latter. 17 refs., 1 fig., 8 tabs.

  4. Rehearsal Strategies Can Enlarge or Diminish the Spacing Effect: Pure versus Mixed Lists and Encoding Strategy

    ERIC Educational Resources Information Center

    Delaney, Peter F.; Verkoeijen, Peter P. J. L.

    2009-01-01

    Using 5 experiments, the authors explored the dependency of spacing effects on rehearsal patterns. Encouraging rehearsal borrowing produced opposing effects on mixed lists (containing both spaced and massed repetitions) and pure lists (containing only one or the other), magnifying spacing effects on mixed lists but diminishing spacing effects on…

  5. Rehearsal strategies can enlarge or diminish the spacing effect: pure versus mixed lists and encoding strategy.

    PubMed

    Delaney, Peter F; Verkoeijen, Peter P J L

    2009-09-01

    Using 5 experiments, the authors explored the dependency of spacing effects on rehearsal patterns. Encouraging rehearsal borrowing produced opposing effects on mixed lists (containing both spaced and massed repetitions) and pure lists (containing only one or the other), magnifying spacing effects on mixed lists but diminishing spacing effects on pure lists. Rehearsing with borrowing produced large spacing effects on mixed lists but not on pure lists for both free recall (Experiment 1) and recognition (Experiment 2). In contrast, rehearsing only the currently visible item produced spacing effects on both mixed lists and pure lists in free recall (Experiment 3) and recognition (Experiment 4). Experiment 5 demonstrated these effects using a fully within-subjects design. Rehearse-aloud protocols showed that rehearsal borrowing redistributed study from massed to spaced items on mixed lists, especially during massed presentations.

  6. Dynamic route guidance strategy in a two-route pedestrian-vehicle mixed traffic flow system

    NASA Astrophysics Data System (ADS)

    Liu, Mianfang; Xiong, Shengwu; Li, Bixiang

    2016-05-01

    With the rapid development of transportation, traffic questions have become the major issue for social, economic and environmental aspects. Especially, during serious emergencies, it is very important to alleviate road traffic congestion and improve the efficiency of evacuation to reduce casualties, and addressing these problems has been a major task for the agencies responsible in recent decades. Advanced road guidance strategies have been developed for homogeneous traffic flows, or to reduce traffic congestion and enhance the road capacity in a symmetric two-route scenario. However, feedback strategies have rarely been considered for pedestrian-vehicle mixed traffic flows with variable velocities and sizes in an asymmetric multi-route traffic system, which is a common phenomenon in many developing countries. In this study, we propose a weighted road occupancy feedback strategy (WROFS) for pedestrian-vehicle mixed traffic flows, which considers the system equilibrium to ease traffic congestion. In order to more realistic simulating the behavior of mixed traffic objects, the paper adopted a refined and dynamic cellular automaton model (RDPV_CA model) as the update mechanism for pedestrian-vehicle mixed traffic flow. Moreover, a bounded rational threshold control was introduced into the feedback strategy to avoid some negative effect of delayed information and reduce. Based on comparisons with the two previously proposed strategies, the simulation results obtained in a pedestrian-vehicle traffic flow scenario demonstrated that the proposed strategy with a bounded rational threshold was more effective and system equilibrium, system stability were reached.

  7. Code Switching and Code-Mixing as a Communicative Strategy in Multilingual Discourse.

    ERIC Educational Resources Information Center

    Tay, Mary W. J.

    1989-01-01

    Examines how code switching and mixing are used as communication strategies in multilingual communities and discusses how to establish solidarity and rapport in multilingual discourse. Examples from the main languages spoken in Singapore--English, Mandarin, Hokkien, and Teochew--are used. (Author/OD)

  8. Learning and Study Strategies of Students with Traumatic Brain Injury: A Mixed Method Study

    ERIC Educational Resources Information Center

    Bush, Erin; Hux, Karen; Zickefoose, Samantha; Simanek, Gina; Holmberg, Michelle; Henderson, Ambyr

    2011-01-01

    The purpose of this research was to explore the perceptions of four college students with severe traumatic brain injury and people associated with them regarding the use of learning skills and study strategies. The researchers employed a concurrent mixed method design using descriptive quantitative data as well as qualitative multiple case study…

  9. Optimal mission planning of GEO on-orbit refueling in mixed strategy

    NASA Astrophysics Data System (ADS)

    Chen, Xiao-qian; Yu, Jing

    2017-04-01

    The mission planning of GEO on-orbit refueling (OOR) in Mixed strategy is studied in this paper. Specifically, one SSc will be launched to an orbital slot near the depot when multiple GEO satellites are reaching their end of lives. The SSc replenishes fuel from the depot and then extends the lifespan of the target satellites via refueling. In the mixed scenario, only some of the target satellites could be served by the SSc, and the remaining ones will be fueled by Pseudo SScs (the target satellite which has already been refueled by the SSc and now has sufficient fuel for its operation as well as the fuel to refuel other target satellites is called Pseudo SSc here). The mission sequences and fuel mass of the SSc and Pseudo SScs, the dry mass of the SSc are used as design variables, whereas the economic benefit of the whole mission is used as design objective. The economic cost and benefit models are stated first, and then a mathematical optimization model is proposed. A comprehensive solution method involving enumeration, particle swarm optimization and modification is developed. Numerical examples are carried out to demonstrate the effectiveness of the model and solution method. Economic efficiencies of different OOR strategies are compared and discussed. The mixed strategy would perform better than the other strategies only when the target satellites satisfy some conditions. This paper presents an available mixed strategy scheme for users and analyzes its advantages and disadvantages by comparing with some other OOR strategies, providing helpful references to decision makers. The best strategy in practical applications depends on the specific demands and user preference.

  10. A novel mixing strategy for maximizing yields of glucose and reducing sugar in enzymatic hydrolysis of cellulose.

    PubMed

    Pal, Ramendra Kishor; Chakraborty, Saikat

    2013-11-01

    This work explores the effects of mixing on enzymatic hydrolysis of cellulose to innovate a novel mixing strategy that maximizes glucose and reducing sugar yields for production of cellulosic ethanol while reducing the power required for reactor mixing. Batch experiments of cellulose hydrolysis are performed under aseptic conditions for 72 h at various substrate loading (2-6% wt./vol.), where the reactor mixing is terminated after different intervals of time ranging from 0 to 72 h. We find that initial mixing for a certain 'optimal mixing time' followed by no mixing for the rest of the reaction time maximizes glucose and reducing sugar yields. We report a maximum of 26% and 31% increase in glucose and reducing yields, respectively, in case of optimal mixing over continuous mixing for 2% substrate loading. We obtain an algebraic expression that predicts that the optimal mixing time increases exponentially with substrate loading.

  11. Deduction of initial strategy distributions of agents in mix-game models

    NASA Astrophysics Data System (ADS)

    Gou, Chengling

    2006-11-01

    This paper reports the effort of deducing the initial strategy distributions (ISDs) of agents in mix-game models that is used to predict a real financial time series generated from a target financial market. Using mix-games to predict Shanghai Index, we find that the time series of prediction accurate rates is sensitive to the ISDs of agents in group 2 who play a minority game, but less sensitive to the ISDs of agents in group 1 who play a majority game. And agents in group 2 tend to cluster in full strategy space (FSS) if the real financial time series has obvious tendency (upward or downward), otherwise they tend to scatter in FSS. We also find that the ISDs and the number of agents in group 1 influence the level of prediction accurate rates. Finally, this paper gives suggestion about further research.

  12. Using Mixed-Modality Learning Strategies via e-Learning for Second Language Vocabulary Acquisition

    ERIC Educational Resources Information Center

    Yang, Fang-Chuan Ou; Wu, Wen-Chi Vivian

    2015-01-01

    This study demonstrated an e-learning system, MyEVA, based on a mixed-modality vocabulary strategy in assisting learners of English as a second language (L2 learners) to improve their vocabulary. To explore the learning effectiveness of MyEVA, the study compared four vocabulary-learning techniques, MyEVA in preference mode, MyEVA in basic mode, an…

  13. Temporal and spatial allocation of motor preparation during a mixed-strategy game.

    PubMed

    Mikulić, Areh; Dorris, Michael C

    2008-10-01

    Adopting a mixed response strategy in competitive situations can prevent opponents from exploiting predictable play. What drives stochastic action selection is unclear given that choice patterns suggest that, on average, players are indifferent to available options during mixed-strategy equilibria. To gain insight into this stochastic selection process, we examined how motor preparation was allocated during a mixed-strategy game. If selection processes on each trial reflect a global indifference between options, then there should be no bias in motor preparation (unbiased preparation hypothesis). If, however, differences exist in the desirability of options on each trial then motor preparation should be biased toward the preferred option (biased preparation hypothesis). We tested between these alternatives by examining how saccade preparation was allocated as human subjects competed against an adaptive computer opponent in an oculomotor version of the game "matching pennies." Subjects were free to choose between two visual targets using a saccadic eye movement. Saccade preparation was probed by occasionally flashing a visual distractor at a range of times preceding target presentation. The probability that a distractor would evoke a saccade error, and when it failed to do so, the probability of choosing each of the subsequent targets quantified the temporal and spatial evolution of saccade preparation, respectively. Our results show that saccade preparation became increasingly biased as the time of target presentation approached. Specifically, the spatial locus to which saccade preparation was directed varied from trial to trial, and its time course depended on task timing.

  14. Quantitative multivariate analytical strategy for paleoenvironmental analysis of mixed benthic foraminiferal assemblages

    SciTech Connect

    Lagoe, M.B. )

    1991-03-01

    Fossil assemblages of benthic foraminifera commonly contain taxa that were not associated together during life. A variety of processes act to modify living assemblages during the transition to fossil assemblages-transport of tests by traction and gravity currents, taphonomic filtering, and rapid shifting of environments in response to sea level fluctuations, to name a few. Unraveling the nature of faunal mixing can provide insights into depositional processes and paleoenvironmental history of particular lithofacies. A quantitative multivariate analytical strategy is presented to address these problems, using the late Cenozoic Yakataga Formation, Gulf of Alaska as a specific example. A variety of lithofacies are present within the Yakataga Formation including normal marine mudstones, sandstones, coquinas and conglomerates and glaciomarine diamictites. Comparison of fossil assemblages with modern foraminiferal distributions indicates significant faunal mixing in most lithofacies, particularly the diamictites. Quantitative analysis includes cluster analysis to define broad patterns in faunal similarity, R-mode factor analysis to define species interrelationships, and Q-mode polytopic vector analysis to 'unmix' the assemblages into their component biofacies. Two broad patterns of faunal mixing are identified: (1) comprehensive mixing of all possible biofacies within a particular bathymetric range and (2) mixing of very shallow (innermost neritic) with deeper (upper bathyal) assemblages, bypassing environments from outer neritic areas. Diamictites are shown to form in a variety of water depths from inner neritic to upper bathyal.

  15. A mixed connection recovery strategy for surviving dual link failure in WDM networks

    NASA Astrophysics Data System (ADS)

    Yadav, Dharmendra Singh; Rana, Santosh; Prakash, Shashi

    2013-03-01

    As the size and complexity of a network increases, the probability of a dual link failure also increases. For recovering the dual link failures, two strategies have been presented in past. As per the first strategy, SPP-MAS (Shared Path Protection-Maximum Allowable Sharing), the sharing of backup lightpaths in SPP (Shared Path Protection) has been reduced, and in the second strategy TBPS (Two Backup Path Shared), the reservation of two backup lightpaths for each primary lightpath has been undertaken. The main flaw of these strategies is the requirement of redundant network resources towards the establishment of backup lightpaths, and the occurrence of trap problem after the second link fails. To minimize the redundant backup resources and the trap problem, a mixed connection recovery algorithm namely Adaptive Backup Routing over Reserved Resources (ABRRR) has been proposed. The design of ABRRR takes leverage of both, the pre-planned, and the post-failure connection recovery mechanisms. In ABRRR, the failed connections are re-provisioned adaptively over the pre-allocated backup network resources. Adaptive re-provisioning of the failed connection minimizes the trap problem. Using simulation experiments, we undertake a comparative study of the proposed strategy with the existing strategies (i.e. SPP-MAS and TBPS) under the network parameters of Blocking Probability, Dual Restorability, and Resource Utilization Ratio (RUR). Detailed investigations establish that the use of ABRRR leads to lower Blocking Probability, higher Dual Restorability, and minimized RUR compared to the existing strategies. Results also show that the proposed strategy not only survives more connections but also utilizes fewer numbers of resources compared to the existing strategies.

  16. Acceptability of Strategies to Reduce Student Sitting: A Mixed-Methods Study With College Teachers.

    PubMed

    Laine, Hanna; Araújo-Soares, Vera; Haukkala, Ari; Hankonen, Nelli

    2016-11-18

    Background As school days among adolescents include long periods of prolonged sitting, teachers are key agents to deliver interventions to reduce youth sedentary behavior. To develop an intervention, acceptability and feasibility of alternative strategies should be tested. We aimed to examine teachers' current use and willingness to use various strategies to decrease student sitting and potential barriers and facilitators of use. Method Mixed-methods design with college teachers using an online cross-sectional survey (n = 192) and focus group interviews (n = 13). Findings Although a vast majority (87%) of the teachers found reducing prolonged sitting an important goal, only 47% were actually including practices to reduce sitting in their classroom. 89% of the teachers reported willingness to use at least one of the five alternative strategies presented. Focus groups revealed a discussion emphasis on environmental opportunity and motivation as key to implementation. Teachers also generated additional ideas for intervention content. Discussion Despite low levels of current sitting reduction, teachers were willing to try at least one strategy to reduce sitting. Results informed intervention development regarding parameters of use for each strategy. When possible, interventions should provide teachers with a variety of alternative strategies that are easy to use to reduce prolonged sitting.

  17. Nanocasting of Periodic Mesoporous Materials as an Effective Strategy to Prepare Mixed Phases of Titania.

    PubMed

    Mahoney, Luther; Rasalingam, Shivatharsiny; Wu, Chia-Ming; Koodali, Ranjit T

    2015-12-08

    Mesoporous titanium dioxide materials were prepared using a nanocasting technique involving silica SBA-15 as the hard-template. At an optimal loading of titanium precursor, the hexagonal periodic array of pores in SBA-15 was retained. The phases of titanium dioxide could be easily varied by the number of impregnation cycles and the nature of titanium alkoxide employed. Low number of impregnation cycles produced mixed phases of anatase and TiO₂(B). The mesoporous TiO₂ materials were tested for solar hydrogen production, and the material consisting of 98% anatase and 2% TiO₂(B) exhibited the highest yield of hydrogen from the photocatalytic splitting of water. The periodicity of the pores was an important factor that influenced the photocatalytic activity. This study indicates that mixed phases of titania containing ordered array of pores can be prepared by using the nanocasting strategy.

  18. Mixed-gender groups: coping strategies and factors of psychological adaptation in a polar environment.

    PubMed

    Rosnet, Elisabeth; Jurion, Sylvie; Cazes, Geneviève; Bachelard, Claude

    2004-07-01

    The polar environment is often seen as a good analog for long-term space missions in terms of isolation and confinement. This paper focuses on the psychological adaptation of both the men and women in mixed-gender groups in the French polar station Dumont d'Urville. The first 49 expeditions to this station were composed of men only in groups of 25-30. In 2000, two women were included in the first mixed-gender wintering group, followed by five women in 2001. This study on coping strategies and psychological adaptation was included in an end-of-mission debriefing performed by a psychologist. Data were collected using a few quantitative tools and a semi-structured interview, and focused on adaptation to wintering, coping strategies, and information on interpersonal relationships. Including women in a wintering group seems to have had positive effects on the general climate of the group by reducing men's rude behavior, but it also seems to be an important stressor for both men and women when the females' average age is close to the males' because seduction behaviors appear and rivalry, frustration, and sexual harassment frequently result. The use of problem-oriented strategies helps women to adapt. There are strong arguments indicating that living in an isolated and confined environment magnifies the usual difficulties that arise in mixed-gender relationships. Difficulties may be magnified in space since the group size is smaller and the confinement more extreme. This implies the need for rigorous select-in criteria for both men and women, especially for relational criteria, and for group training after selection.

  19. Evolutionary advantage of a mixed strategy for the competence phenotype in bacteria

    NASA Astrophysics Data System (ADS)

    Wylie, Christopher; Levine, Herbert; Kessler, David

    2009-03-01

    Under certain stressful conditions, bacterial species such as B. subtilis undergo a differentiation process in which a finite subpopulation transiently and stochastically enters the ``competent'' state. This state is defined by the ability to import and homologously incorporate extracellular DNA fragments into the genome. This ability is accompanied by a reduced growth rate that tends to slow adaptive evolution. On the other hand, the increased genetic diversity generated by recombination tends to speed evolution. Using stochastic simulation and analytic methods, we show that this tradeoff implies that a ``mixed strategy'' optimizes the rate at which populations acquire beneficial mutations.

  20. A Mixed-Effects Model with Different Strategies for Modeling Volume in Cunninghamia lanceolata Plantations

    PubMed Central

    Guangyi, Mei; Yujun, Sun; Hao, Xu; de-Miguel, Sergio

    2015-01-01

    A systematic evaluation of nonlinear mixed-effect taper models for volume prediction was performed. Of 21 taper equations with fewer than 5 parameters each, the best 4-parameter fixed-effect model according to fitting statistics was then modified by comparing its values for the parameters total height (H), diameter at breast height (DBH), and aboveground height (h) to modeling data. Seven alternative prediction strategies were compared using the best new equation in the absence of calibration data, which is often unavailable in forestry practice. The results of this study suggest that because calibration may sometimes be a realistic option, though it is rarely used in practical applications, one of the best strategies for improving the accuracy of volume prediction is the strategy with 7 calculated total heights of 3, 6 and 9 trees in the largest, smallest and medium-size categories, respectively. We cannot use the average trees or dominant trees for calculating the random parameter for further predictions. The method described here will allow the user to make the best choices of taper type and the best random-effect calculated strategy for each practical application and situation at tree level. PMID:26445505

  1. A Mixed Prioritization Operators Strategy Using A Single Measurement Criterion For AHP Application Development

    NASA Astrophysics Data System (ADS)

    Yuen, Kevin Kam Fung

    2009-10-01

    The most appropriate prioritization method is still one of the unsettled issues of the Analytic Hierarchy Process, although many studies have been made and applied. Interestingly, many AHP applications apply only Saaty's Eigenvector method as many studies have found that this method may produce rank reversals and have proposed various prioritization methods as alternatives. Some methods have been proved to be better than the Eigenvector method. However, these methods seem not to attract the attention of researchers. In this paper, eight important prioritization methods are reviewed. A Mixed Prioritization Operators Strategy (MPOS) is developed to select a vector which is prioritized by the most appropriate prioritization operator. To verify this new method, a case study of high school selection is revised using the proposed method. The contribution is that MPOS is useful for solving prioritization problems in the AHP.

  2. Mixed-complexity artificial grammar learning in humans and macaque monkeys: evaluating learning strategies.

    PubMed

    Wilson, Benjamin; Smith, Kenny; Petkov, Christopher I

    2015-03-01

    Artificial grammars (AG) can be used to generate rule-based sequences of stimuli. Some of these can be used to investigate sequence-processing computations in non-human animals that might be related to, but not unique to, human language. Previous AG learning studies in non-human animals have used different AGs to separately test for specific sequence-processing abilities. However, given that natural language and certain animal communication systems (in particular, song) have multiple levels of complexity, mixed-complexity AGs are needed to simultaneously evaluate sensitivity to the different features of the AG. Here, we tested humans and Rhesus macaques using a mixed-complexity auditory AG, containing both adjacent (local) and non-adjacent (longer-distance) relationships. Following exposure to exemplary sequences generated by the AG, humans and macaques were individually tested with sequences that were either consistent with the AG or violated specific adjacent or non-adjacent relationships. We observed a considerable level of cross-species correspondence in the sensitivity of both humans and macaques to the adjacent AG relationships and to the statistical properties of the sequences. We found no significant sensitivity to the non-adjacent AG relationships in the macaques. A subset of humans was sensitive to this non-adjacent relationship, revealing interesting between- and within-species differences in AG learning strategies. The results suggest that humans and macaques are largely comparably sensitive to the adjacent AG relationships and their statistical properties. However, in the presence of multiple cues to grammaticality, the non-adjacent relationships are less salient to the macaques and many of the humans.

  3. Closed-loop enhancement of jet mixing with extremum-seeking and physics-based strategies

    NASA Astrophysics Data System (ADS)

    Wu, Z.; Zhou, Y.; Cao, H. L.; Li, W. J.

    2016-06-01

    The closed-loop control of a turbulent round air jet is experimentally investigated based on two unsteady minijets, with a view to enhancing jet mixing. The two minijets are placed at diametrically opposite locations upstream of the nozzle exit. The open-loop control experiments are first performed. Given the mass flow rate ratio C m of the minijets to that of the main jet, the decay rate overline{K} of jet centerline mean velocity exhibits a maximum at the frequency ratio f e/ f 0 ≈ 1.0, where f e and f 0 are the excitation frequency of minijets and the preferred mode frequency of the natural main jet, respectively. An extremum-seeking feedback control has been developed to achieve autonomously the optimal control performance. It has been found that, given C m, this closed-loop control technique may obtain automatically and rapidly the optimal value of f e and the desired or maximum overline{K}, as achieved in the open-loop control. This control technique is robust and adaptable when the Reynolds number and initial excitation frequency are changed separately. A flow-physics-based feedback control strategy has also been investigated, which could achieve the optimal control performance automatically with a shorter convergence time than the extremum-seeking control, not robust though.

  4. Coping strategies and styles of family carers of persons with enduring mental illness: a mixed methods analysis.

    PubMed

    Kartalova-O'Doherty, Yulia; Doherty, Donna Tedstone

    2008-03-01

    A qualitative exploratory study investigated the experiences and needs of family carers of persons with enduring mental illness in Ireland. The current mixed-methods secondary study used content analysis and statistical procedures to identify and explore the coping strategies emerging from the original interviews. The majority of family carers reported use of active behavioural coping strategies, sometimes combined with active cognitive or avoidance strategies. The percentage of cares reporting use of active cognitive strategies was the lowest among those whose ill relative lived in their home, and the highest among those whose relative lived independently. Participants with identified active cognitive strategies often reported that their relative was employed or in training. Participants who reported use of avoidance strategies were significantly younger than participants who did not report use of such strategies. The lowest percentage of avoidance strategies was among participants whose ill relative lived independently, whereas the highest was among carers whose relative lived in their home. The findings of this study highlight the importance of a contextual approach to studying coping styles and processes. Further research questions and methodological implications are discussed.

  5. Mixed-Mode Surveys: A Strategy to Reduce Costs and Enhance Response Rates

    ERIC Educational Resources Information Center

    Tobin, Daniel; Thomson, Joan; Radhakrishna, Rama; LaBorde, Luke

    2012-01-01

    Mixed-mode surveys present one opportunity for Extension to determine program outcomes at lower costs. In order to conduct a follow-up evaluation, we implemented a mixed-mode survey that relied on communication using the Web, postal mailings, and telephone calls. Using multiple modes conserved costs by reducing the number of postal mailings yet…

  6. Disease Risk Mitigation: The Equivalence of Two Selective Mixing Strategies on Aggregate Contact Patterns & Resulting Epidemic Spread☆

    PubMed Central

    Morin, Benjamin R; Perrings, Charles; Levin, Simon; Kinzig, Ann

    2014-01-01

    The personal choices affecting the transmission of infectious diseases include the number of contacts an individual makes, and the risk-characteristics of those contacts. We consider whether these different choices have distinct implications for the course of an epidemic. We also consider whether choosing contact mitigation (how much to mix) and affinity mitigation (with whom to mix) strategies together has different epidemiological effects than choosing each separately. We use a set of differential equation compartmental models of the spread of disease, coupled with a model of selective mixing. We assess the consequences of varying contact or affinity mitigation as a response to disease risk. We do this by comparing disease incidence and dynamics under varying contact volume, contact type, and both combined across several different disease models. Specifically, we construct a change of variables that allows one to transition from contact mitigation to affinity mitigation, and vice versa. In the absence of asymptomatic infection we find no difference in the epidemiological impacts of the two forms of disease risk mitigation. Furthermore, since models that include both mitigation strategies are under-determined, varying both results in no outcome that could not be reached by choosing either separately. Which strategy is actually chosen then depends not on their epidemiological consequences, but on the relative cost of reducing contact volume versus altering contact type. Although there is no fundamental epidemiological difference between the two forms of mitigation, the social cost of alternative strategies can be very different. From a social perspective, therefore, whether one strategy should be promoted over another depends on economic not epidemiological factors. PMID:25150459

  7. A mixed-solvent strategy for facile and green preparation of graphene by liquid-phase exfoliation of graphite

    NASA Astrophysics Data System (ADS)

    Yi, Min; Shen, Zhigang; Ma, Shulin; Zhang, Xiaojing

    2012-08-01

    A versatile and scalable mixed-solvent strategy, by which two mediocre solvents could be combined into good solvents for exfoliating graphite, is demonstrated for facile and green preparation of graphene by liquid-phase exfoliation of graphite. Mild sonication of crystal graphite powder in a mixture of water and alcohol could yield graphene nanosheets, which formed a highly stable suspension in the mixed solvents. The graphene yield was estimated as 10 wt%. The optimum mass fraction of ethanol in water-ethanol mixtures and isopropanol in water-isopropanol mixtures was experimentally determined as 40 and 55 % respectively, which could be roughly predicted by the theory of Hansen solubility parameters. Statistics based on atomic force microscopic analysis show that up to 86 % of the prepared nanosheets were less than 10-layer thick with a monolayer fraction of 8 %. High resolution transmission electron microscopy, infrared spectroscopy, X-ray diffraction, and Raman spectrum analysis of the vacuum-filtered films suggest the graphene sheets to be largely free of defects and oxides. The proposed mixed-solvent strategy here extends the scope for liquid-phase processing graphene and gives researchers great freedom in designing ideal solvent systems for specific applications.

  8. Development of energy efficient mixing strategies in egg-shaped anaerobic reactors through 3D CFD simulation.

    PubMed

    Hernandez-Aguilar, Eduardo; Alvarado-Lassman, Alejandro; Osorio-Mirón, Anselmo; Méndez-Contreras, Juan M

    2016-01-01

    This work describes a 3D computational fluid dynamic model, which characterizes the hydrodynamic behavior of a mixing strategy applied to egg-shaped reactors that lack a mechanical stirring device. The model is based on Navier-Stokes and material balance equations without a chemical reaction. To describe the behavior of mixing, initial water feed flows of 6, 7.5 and 9 mL s(-1) were used. An experimental validation was subsequently carried out using a pulse technique, with NaCl as a tracer. The residence time distributions were quantitatively determined. Then, the degradation process of the wastewater sludge was characterized by studying the time dependence of the dynamic viscosity, the concentration of volatile solids and the density of wastewater sludge. The data resulting were introduced into the validated model, and five feed flows from 9 to 13 mL s(-1), the best performance found was with feed flow of 11 mL s(-1).

  9. How L2 Legal Writers Use Strategies for Scholarly Writing: A Mixed Methods Study

    ERIC Educational Resources Information Center

    Bain Butler, Donna

    2010-01-01

    This dissertation research fills existing gaps regarding the practices and processes of teaching second language (L2) writers at higher ranges of proficiency in law school context. It is a mixed methods, longitudinal, descriptive, writer-centered study. The research purpose was to explore strategic competence as a catalyst for professional…

  10. Performance evaluation of ant colony optimization-based solution strategies on the mixed-model assembly line balancing problem

    NASA Astrophysics Data System (ADS)

    Akpinar, Sener; Mirac Bayhan, G.

    2014-06-01

    The aim of this article is to compare the performances of iterative ant colony optimization (ACO)-based solution strategies on a mixed-model assembly line balancing problem of type II (MMALBP-II) by addressing some particular features of real-world assembly line balancing problems such as parallel workstations and zoning constraints. To solve the problem, where the objective is to minimize the cycle time (i.e. maximize the production rate) for a predefined number of workstations in an existing assembly line, two ACO-based approaches which differ in the mission assigned to artificial ants are used. Furthermore, each ACO-based approach is conducted with two different pheromone release strategies: global and local pheromone updating rules. The four ACO-based approaches are used for solving 20 representative MMALBP-II to compare their performance in terms of computational time and solution quality. Detailed comparison results are presented.

  11. Occupational competence strategies in old age: a mixed-methods comparison between Hispanic women with different levels of daily participation.

    PubMed

    Orellano, Elsa M; Mountain, Gail; Varas, Nelson; Labault, Nirzka

    2014-01-01

    In this pilot study, we explored the difference in the use of occupational competence strategies for daily participation between more active and less active older Hispanic women. Twenty-nine women who were 70 and older and lived alone participated in this study. We used a mixed-methods design by which the principal investigator administered a tool to measure participation restrictions during the quantitative phase and conducted in-depth interviews with a subsample in the qualitative phase. More active women predominantly used transportation resources, emotional social support, and spirituality to support participation in life activities. Less active women used more practical social support, assistive technology, and environmental modifications. Personal facilitators seemed to directly modify these strategies. These results suggest that older women with different activity levels use distinct internal and external resources to maintain or enhance daily participation. Future studies should explore whether these resources remain consistent across gender, living status, and ethnicity.

  12. Ultrasmooth Perovskite Film via Mixed Anti-Solvent Strategy with Improved Efficiency.

    PubMed

    Yu, Yu; Yang, Songwang; Lei, Lei; Cao, Qipeng; Shao, Jun; Zhang, Sheng; Liu, Yan

    2017-02-01

    Most antisolvents employed in previous research were miscible with perovskite precursor solution. They always led to fast formation of perovskite even if the intermediate stage existed, which was not beneficial to obtain high quality perovskite films and made the formation process less controllable. In this work, a novel ethyl ether/n-hexane mixed antisolvent (MAS) was used to achieve high nucleation density and slow down the formation process of perovskite, producing films with improved orientation of grains and ultrasmooth surfaces. These high quality films exhibited efficient charge transport at the interface of perovskite/hole transport material and perovskite solar cells based on these films showed greatly improved performance with the best power conversion efficiency of 17.08%. This work also proposed a selection principle of MAS and showed that solvent engineering by designing the mixed antisolvent system can lead to the fabrication of high-performance perovskite solar cells.

  13. A Mixed Methods Analysis of a Single-Course Strategy to Integrate Technology into PETE

    ERIC Educational Resources Information Center

    Wyant, James D.; Jones, Emily M.; Bulger, Sean M.

    2015-01-01

    In recent years increased attention has been placed on physical education teachers' use of technology. To date little research has been disseminated regarding the strategies physical education teacher education (PETE) programs are employing to prepare preservice teacher's to use technology. The purpose of this study was to examine the influence a…

  14. New four-pronged approach to wellness combines an eclectic mix of strategies.

    PubMed

    2006-09-01

    Humana uses non-traditional means in an effort to keep seniors healthy. Taking care of people when they're sick is important, but Humana has decided that seniors in particular have a strong interest in maintaining their health, and it is rolling out a new initiative aimed at helping them do just that. The program offers a mix of opportunities related to cognitive function, physical fitness, and nutrition, but there is also a strong component geared toward advocacy. Humana is hoping that the payoff will come in the form of improved health and reduced claims costs.

  15. Mixed fuel strategy for carbon deposition mitigation in solid oxide fuel cells at intermediate temperatures.

    PubMed

    Su, Chao; Chen, Yubo; Wang, Wei; Ran, Ran; Shao, Zongping; Diniz da Costa, João C; Liu, Shaomin

    2014-06-17

    In this study, we propose and experimentally verified that methane and formic acid mixed fuel can be employed to sustain solid oxide fuel cells (SOFCs) to deliver high power outputs at intermediate temperatures and simultaneously reduce the coke formation over the anode catalyst. In this SOFC system, methane itself was one part of the fuel, but it also played as the carrier gas to deliver the formic acid to reach the anode chamber. On the other hand, the products from the thermal decomposition of formic acid helped to reduce the carbon deposition from methane cracking. In order to clarify the reaction pathways for carbon formation and elimination occurring in the anode chamber during the SOFC operation, O2-TPO and SEM analysis were carried out together with the theoretical calculation. Electrochemical tests demonstrated that stable and high power output at an intermediate temperature range was well-maintained with a peak power density of 1061 mW cm(-2) at 750 °C. With the synergic functions provided by the mixed fuel, the SOFC was running for 3 days without any sign of cell performance decay. In sharp contrast, fuelled by pure methane and tested at similar conditions, the SOFC immediately failed after running for only 30 min due to significant carbon deposition. This work opens a new way for SOFC to conquer the annoying problem of carbon deposition just by properly selecting the fuel components to realize their synergic effects.

  16. Three-dimensional simulation strategy to determine the effects of turbulent mixing on inertial-confinement-fusion capsule performance.

    PubMed

    Haines, Brian M; Grinstein, Fernando F; Fincke, James R

    2014-05-01

    In this paper, we present and justify an effective strategy for performing three-dimensional (3D) inertial-confinement-fusion (ICF) capsule simulations. We have evaluated a frequently used strategy in which two-dimensional (2D) simulations are rotated to 3D once sufficient relevant 2D flow physics has been captured and fine resolution requirements can be restricted to relatively small regions. This addresses situations typical of ICF capsules which are otherwise prohibitively intensive computationally. We tested this approach for our previously reported fully 3D simulations of laser-driven reshock experiments where we can use the available 3D data as reference. Our studies indicate that simulations that begin as purely 2D lead to significant underprediction of mixing and turbulent kinetic energy production at later time when compared to the fully 3D simulations. If, however, additional suitable nonuniform perturbations are applied at the time of rotation to 3D, we show that one can obtain good agreement with the purely 3D simulation data, as measured by vorticity distributions as well as integrated mixing and turbulent kinetic energy measurements. Next, we present results of simulations of a simple OMEGA-type ICF capsule using the developed strategy. These simulations are in good agreement with available experimental data and suggest that the dominant mechanism for yield degradation in ICF implosions is hydrodynamic instability growth seeded by long-wavelength surface defects. This effect is compounded by drive asymmetries and amplified by repeated shock interactions with an increasingly distorted shell, which results in further yield reduction. Our simulations are performed with and without drive asymmetries in order to compare the importance of these effects to those of surface defects; our simulations indicate that long-wavelength surface defects degrade yield by approximately 60% and short-wavelength drive asymmetry degrades yield by a further 30%.

  17. Expected net present value of pure and mixed sexed semen artificial insemination strategies in dairy heifers.

    PubMed

    Olynk, N J; Wolf, C A

    2007-05-01

    Sexed semen has been a long-anticipated tool for dairy farmers to obtain more heifer calves, but challenges exist for integrating sexed semen into commercial dairy farm reproduction programs. The decreased conception rates (CR) experienced with sexed semen make virgin heifers better suited for insemination with sexed semen than lactating dairy cows. This research sought to identify when various sexed semen breeding strategies provided higher expected net present value (NPV) than conventional artificial insemination (AI) breeding schemes, indicating which breeding scheme is advisable under various scenarios. Budgets were developed to calculate the expected NPV of various AI breeding strategies incorporating conventional (non-sexed) and sexed semen. In the base budgets, heifer and bull calf values were held constant at $500 and $110, respectively. The percentage of heifers expected to be born after breeding with conventional and sexed semen used was 49.2 and 90%, respectively. Breeding costs per AI were held constant at $15.00 per AI for conventional semen and $45.00 per AI for sexed semen of approximately the same genetic value. Conventional semen CR of 58 and 65% were used, and an AI submission rate was set at 100%. Breeding strategies with sexed semen were assessed for breakeven heifer calf values and sexed semen costs to obtain a NPV equal to that achieved with conventional semen. Breakeven heifer calf values for pure sexed semen strategies with a constant 58 and 65% base CR in which sexed semen achieved 53% of the base CR are $732.11 and $664.26, respectively. Breakeven sexed semen costs per AI of $17.16 and $22.39, compared with $45.00 per AI, were obtained to obtain a NPV equal to that obtained with pure conventional semen for base CR of 58 and 65%, respectively. The strategy employing purely sexed semen, with base CR of both 58 and 65%, yielded a lower NPV than purely conventional semen in all but the best-case scenario in which sexed semen provides 90% of

  18. Control strategies to prevent total hip replacement-related infections: a systematic review and mixed treatment comparison

    PubMed Central

    Zheng, Henry; Barnett, Adrian G; Merollini, Katharina; Sutton, Alex; Cooper, Nicola; Berendt, Tony; Wilson, Jennie; Graves, Nicholas

    2014-01-01

    Objective To synthesise the available evidence and estimate the comparative efficacy of control strategies to prevent total hip replacement (THR)-related surgical site infections (SSIs) using a mixed treatment comparison. Design Systematic review and mixed treatment comparison. Setting Hospital and other healthcare settings. Participants Patients undergoing THR. Primary and secondary outcome measures The number of THR-related SSIs occurring following the surgical operation. Results 12 studies involving 123 788 THRs and 9 infection control strategies were identified. The strategy of ‘systemic antibiotics+antibiotic-impregnated cement+conventional ventilation’ significantly reduced the risk of THR-related SSI compared with the referent strategy (no systemic antibiotics+plain cement+conventional ventilation), OR 0.13 (95% credible interval (CrI) 0.03–0.35), and had the highest probability (47–64%) and highest median rank of being the most effective strategy. There was some evidence to suggest that ‘systemic antibiotics+antibiotic-impregnated cement+laminar airflow’ could potentially increase infection risk compared with ‘systemic antibiotics+antibiotic-impregnated cement+conventional ventilation’, 1.96 (95% CrI 0.52–5.37). There was no high-quality evidence that antibiotic-impregnated cement without systemic antibiotic prophylaxis was effective in reducing infection compared with plain cement with systemic antibiotics, 1.28 (95% CrI 0.38–3.38). Conclusions We found no convincing evidence in favour of the use of laminar airflow over conventional ventilation for prevention of THR-related SSIs, yet laminar airflow is costly and widely used. Antibiotic-impregnated cement without systemic antibiotics may not be effective in reducing THR-related SSIs. The combination with the highest confidence for reducing SSIs was ‘systemic antibiotics+antibiotic-impregnated cement+conventional ventilation’. Our evidence synthesis underscores the need to review

  19. A coupling strategy for nonlocal and local diffusion models with mixed volume constraints and boundary conditions

    SciTech Connect

    D'Elia, Marta; Perego, Mauro; Bochev, Pavel B.; Littlewood, David John

    2015-12-21

    We develop and analyze an optimization-based method for the coupling of nonlocal and local diffusion problems with mixed volume constraints and boundary conditions. The approach formulates the coupling as a control problem where the states are the solutions of the nonlocal and local equations, the objective is to minimize their mismatch on the overlap of the nonlocal and local domains, and the controls are virtual volume constraints and boundary conditions. When some assumptions on the kernel functions hold, we prove that the resulting optimization problem is well-posed and discuss its implementation using Sandia’s agile software components toolkit. As a result, the latter provides the groundwork for the development of engineering analysis tools, while numerical results for nonlocal diffusion in three-dimensions illustrate key properties of the optimization-based coupling method.

  20. A coupling strategy for nonlocal and local diffusion models with mixed volume constraints and boundary conditions

    DOE PAGES

    D'Elia, Marta; Perego, Mauro; Bochev, Pavel B.; ...

    2015-12-21

    We develop and analyze an optimization-based method for the coupling of nonlocal and local diffusion problems with mixed volume constraints and boundary conditions. The approach formulates the coupling as a control problem where the states are the solutions of the nonlocal and local equations, the objective is to minimize their mismatch on the overlap of the nonlocal and local domains, and the controls are virtual volume constraints and boundary conditions. When some assumptions on the kernel functions hold, we prove that the resulting optimization problem is well-posed and discuss its implementation using Sandia’s agile software components toolkit. As a result,more » the latter provides the groundwork for the development of engineering analysis tools, while numerical results for nonlocal diffusion in three-dimensions illustrate key properties of the optimization-based coupling method.« less

  1. Teachers' implementation of gender-inclusive instructional strategies in single-sex and mixed-sex science classrooms

    NASA Astrophysics Data System (ADS)

    Parker, Lesley H.; Rennie, Léonie J.

    2002-09-01

    Debate continues over the benefits, or otherwise, of single-sex classes in science and mathematics, particularly for the performance of girls. Previous research and analyses of the circumstances surrounding the implementation of single-sex classes warn that the success of the strategy requires due consideration of the nature of the instructional environment for both boys and girls, together with appropriate support for the teachers involved. This article reports the circumstances under which teachers were able to implement gender-inclusive strategies in single-sex science classes in coeducational high schools and documents some of the difficulties faced. The study was part of the Single-Sex Education Pilot Project (SSEPP) in ten high schools in rural and urban Western Australia. Qualitative and quantitative data were gathered during the project from teachers, students and classroom observations. Overall, it was apparent that single-sex grouping created environments in which teachers could implement gender-inclusive science instructional strategies more readily and effectively than in mixed-sex settings. Teachers were able to address some of the apparent shortcomings of the students' previous education (specifically, the poor written and oral communication of boys and the limited experience of girls with 'hands-on' activities and open-ended problem solving). Further, in same-sex classrooms, sexual harassment which inhibited girls' learning was eliminated. The extent to which teachers were successful in implementing gender-inclusive instructional strategies, however, depended upon their prior commitment to the SSEPP as a whole, and upon the support or obstacles encountered from a variety of sources, including parents, the community, students, and non-SSEPP teachers.

  2. Pyramiding, alternating or mixing: comparative performances of deployment strategies of nematode resistance genes to promote plant resistance efficiency and durability

    PubMed Central

    2014-01-01

    Background Resistant cultivars are key elements for pathogen control and pesticide reduction, but their repeated use may lead to the emergence of virulent pathogen populations, able to overcome the resistance. Increased research efforts, mainly based on theoretical studies, explore spatio-temporal deployment strategies of resistance genes in order to maximize their durability. We evaluated experimentally three of these strategies to control root-knot nematodes: cultivar mixtures, alternating and pyramiding resistance genes, under controlled and field conditions over a 3-years period, assessing the efficiency and the durability of resistance in a protected crop rotation system with pepper as summer crop and lettuce as winter crop. Results The choice of the resistance gene and the genetic background in which it is introgressed, affected the frequency of resistance breakdown. The pyramiding of two different resistance genes in one genotype suppressed the emergence of virulent isolates. Alternating different resistance genes in rotation was also efficient to decrease virulent populations in fields due to the specificity of the virulence and the trapping effect of resistant plants. Mixing resistant cultivars together appeared as a less efficient strategy to control nematodes. Conclusions This work provides experimental evidence that, in a cropping system with seasonal sequences of vegetable species, pyramiding or alternating resistance genes benefit yields in the long-term by increasing the durability of resistant cultivars and improving the long-term control of a soil-borne pest. To our knowledge, this result is the first one obtained for a plant-nematode interaction, which helps demonstrate the general applicability of such strategies for breeding and sustainable management of resistant cultivars against pathogens. PMID:24559060

  3. The insectivorous bat Pipistrellus nathusii uses a mixed-fuel strategy to power autumn migration.

    PubMed

    Voigt, Christian C; Sörgel, Karin; Šuba, Jurģis; Keišs, Oskars; Pētersons, Gunārs

    2012-09-22

    In contrast to birds, bats are possibly limited in their capacity to use body fat as an energy source for long migrations. Here, we studied the fuel choice of migratory Pipistrellus nathusii (approximate weight: 8 g) by analysing the stable carbon isotope ratio (δ(13)C(V-PDB)) of breath and potential energy sources. Breath δ(13)C(V-PDB) was intermediate between δ(13)C(V-PDB) of insect prey and adipocyte triacylglycerols, suggesting a mixed-fuel use of P. nathusii during autumn migration. To clarify the origin of oxidized fatty acids, we performed feeding experiments with captive P. nathusii. After an insect diet, bat breath was enriched in (13)C relative to the bulk and fat portion of insects, but not deviating from the non-fat portion of insects, suggesting that bats oxidized exogenous proteins and carbohydrates, but not exogenous fatty acids. A feeding experiment with (13)C-labelled substrates confirmed these findings. In conclusion, migratory P. nathusii oxidized dietary proteins directly from insects captured en route in combination with endogenous fatty acids from adipocytes, and replenished their body reserves by routing dietary fatty acids to their body reserves.

  4. Spontaneous Time Symmetry Breaking in System with Mixed Strategy Nash Equilibrium: Evidences in Experimental Economics Data

    NASA Astrophysics Data System (ADS)

    Wang, Zhijian; Xu, Bin; Zhejiang Collaboration

    2011-03-01

    In social science, laboratory experiment with human subjects' interaction is a standard test-bed for studying social processes in micro level. Usually, as in physics, the processes near equilibrium are suggested as stochastic processes with time-reversal symmetry (TRS). To the best of our knowledge, near equilibrium, the breaking time symmetry, as well as the existence of robust time anti-symmetry processes, has not been reported clearly in experimental economics till now. By employing Markov transition method to analysis the data from human subject 2x2 Games with wide parameters and mixed Nash equilibrium, we study the time symmetry of the social interaction process near Nash equilibrium. We find that, the time symmetry is broken, and there exists a robust time anti-symmetry processes. We also report the weight of the time anti-symmetry processes in the total processes of each the games. Evidences in laboratory marketing experiments, at the same time, are provided as one-dimension cases. In these cases, time anti-symmetry cycles can also be captured. The proposition of time anti-symmetry processes is small, but the cycles are distinguishable.

  5. Process evaluation of a diversity training program: the value of a mixed method strategy.

    PubMed

    Celik, Halime; Abma, Tineke A; Klinge, Ineke; Widdershoven, Guy A M

    2012-02-01

    Patients' health and health needs are influenced by categories of difference like sex, gender, ethnic origin and socioeconomic status (SES). To enhance awareness of this diversity among patients and to provide holistic care for them, health professionals should first be aware of the relation between dimensions of diversity and patients' health and health demands. This paper presents a formative process evaluation of a diversity sensitivity training programme for healthcare professionals. The training was implemented in three healthcare settings (mental healthcare, nursing home and hospital care). Mixed methods were used to monitor the implementation of the training and its effects after three years. Findings demonstrate that the training stimulated participants' awareness, knowledge and critical attitudes towards diversity. Their motivation and willingness to take action regarding diversity was also enhanced. Yet these developments were less apparent among nursing home participants who felt less satisfied and did not develop a critical perspective on this issue. Qualitative data were helpful to explain differences between the settings. By means of the combination of quantitative and qualitative data, we can conclude that individual learning was not enough to guarantee a sensitive approach to diversity at the organizational level.

  6. Savannah River Site Mixed Waste Management Facility Southwest Plume Tritium Phytoremediation Evaluating Irrigation Management Strategies Over 25 Years

    SciTech Connect

    Riah, Susan; Rebel, Karin

    2004-02-27

    To minimize movement of tritium into surface waters at the Mixed Waste Management Facility at the Savannah River Site, tritium contaminated seepage water is being retained in a constructed pond and used to irrigate forest acreage that lies above the pond and over the contaminated groundwater. Twenty five-year potential evapotranspiration and average precipitation are 1443 mm/year and 1127 mm/year, respectively, for the region in which the site is located. Management of the application of tritium contaminated irrigation water needs to be evaluated in the context of the large amount of rainfall relative to evapotranspiration, the strong seasonality in evapotranspiration, and intraannual and inter-annual variability in precipitation. A dynamic simulation model of water and tritium fluxes in the soil-plant-atmosphere continuum was developed to assess the efficiency (tritium transpired/tritium applied) of several irrigation management strategies.

  7. Pre-breeding energetic management in a mixed-strategy breeder.

    PubMed

    Hennin, Holly L; Legagneux, Pierre; Bêty, Joël; Williams, Tony D; Gilchrist, H Grant; Baker, Tyne M; Love, Oliver P

    2015-01-01

    Integrative biologists have long appreciated that the effective acquisition and management of energy prior to breeding should strongly influence fitness-related reproductive decisions (timing of breeding and reproductive investment). However, because of the difficulty in capturing pre-breeding individuals, and the tendency towards abandonment of reproduction after capture, we know little about the underlying mechanisms of these life-history decisions. Over 10 years, we captured free-living, arctic-breeding common eiders (Somateria mollissima) up to 3 weeks before investment in reproduction. We examined and characterized physiological parameters predicted to influence energetic management by sampling baseline plasma glucocorticoids (i.e., corticosterone), very-low-density lipoprotein (VLDL), and vitellogenin (VTG) for their respective roles in mediating energetic balance, rate of condition gain (physiological fattening rate) and reproductive investment. Baseline corticosterone increased significantly from arrival to the initiation of reproductive investment (period of rapid follicular growth; RFG), and showed a positive relationship with body mass, indicating that this hormone may stimulate foraging behaviour to facilitate both fat deposition and investment in egg production. In support of this, we found that VLDL increased throughout the pre-breeding period, peaking as predicted during RFG. Female eiders exhibited unprecedentedly high levels of VTG well before their theoretical RFG period, a potential strategy for pre-emptively depositing available protein stores into follicles while females are simultaneously fattening. This study provides some of the first data examining the temporal dynamics and interaction of the energetic mechanisms thought to be at the heart of individual variation in reproductive decisions and success in many vertebrate species.

  8. Satisfaction of patients with directly observed treatment strategy in Addis Ababa, Ethiopia: A mixed-methods study

    PubMed Central

    Getahun, Belete; Nkosi, Zethu Zerish

    2017-01-01

    Background Directly observed treatment, short course (DOTS) strategy has been a cornerstone for Tuberculosis (TB) control programs in developing countries. However, in Ethiopia satisfaction level of patients’ with TB with the this strategy is not well understood. Therefore, the study aimed to assess the satisfaction level of patients with TB with the DOTS. Method Explanatory sequential mixed method design was carried out in Addis Ababa, Ethiopia. Interviewer-administered questionnaire with 601 patients with TB who were on follow-up was employed in the quantitative approach. In the qualitative approach telephonic-interview with 25 persons lost to follow-up and focus group discussions with 23 TB experts were conducted. Result Sixty seven percent of respondent was satisfied with the DOTS. Rural residency (AOR = 3.4, 95% CI 1.6, 7.6), having TB symptoms (AOR = 0.6, 95% CI 0.4, 0.94) and treatment supporter (AOR = 4.3, 95%CI 2.7, 6.8) were associated with satisfaction with DOTS. In qualitative finding, all persons lost to follow-up were dissatisfied while TB experts enlightened lack of evidence to affirm the satisfaction level of patients with DOTS. Explored factors contributing to satisfaction include: on time availability of health care providers, DOTS service delivery process, general condition of health care facilities, nutritional support and transportation. Conclusion DOTS is limited to satisfy patients with TB and lacks a consistent system that determines the satisfaction level of patients with TB. Therefore, DOTS strategy needs to have a system to captures patients’ satisfaction level to respond on areas that need progress to improve DOTS service quality. PMID:28182754

  9. Lay Explanatory Models of Depression and Preferred Coping Strategies among Somali Refugees in Norway. A Mixed-Method Study

    PubMed Central

    Markova, Valeria; Sandal, Gro M.

    2016-01-01

    Objective: Refugees are at high risk of experiencing mental health problems due to trauma in their pasts and to acculturation stress as they settle in a new country. To develop efficient health services that meet the needs of refugees from different regions, an understanding is required of how they make sense of and prefer to cope with mental health problems. This study aims to investigate lay explanatory models of depression and preferred coping strategies among Somali refugees in Norway. Methods: The study used a mixed-method design with a vignette describing a moderately depressed person based on ICD-10 criteria. Firstly, a survey study was performed among Somali refugees (n = 101). Respondents were asked to give advice to the vignette character and complete the Cross-Cultural Depression Coping Inventory and the General Help-Seeking Questionnaire. Secondly, focus group interviews (n = 10) were conducted separately with males and females to examine the relationship between the explanatory models of depression and the preferred coping strategies. Results: The participants showed a strong preference for coping with depression by religious practices and reliance on family, friends, and their ethnic/religious community, rather than by seeking professional treatment from public health services (e.g., medical doctors, psychologists). Depressive symptoms were conceptualized as a problem related to cognition (thinking too much) and emotion (sadness), but not to biological mechanisms, and they were thought to result from spiritual possession, stress as a result of social isolation, and/or past trauma. Independently of time in exile, the participants showed a strong identification with their ethnic origin and associated values. Because participants emphasized the need to obey and follow the views of elders, fathers, and spiritual leaders, these authorities seemed to be “gatekeepers” for access to mental health services. Conclusion: The results highlight that mental

  10. A hidden Markov model to identify and adjust for selection bias: an example involving mixed migration strategies

    PubMed Central

    Fieberg, John R; Conn, Paul B

    2014-01-01

    An important assumption in observational studies is that sampled individuals are representative of some larger study population. Yet, this assumption is often unrealistic. Notable examples include online public-opinion polls, publication biases associated with statistically significant results, and in ecology, telemetry studies with significant habitat-induced probabilities of missed locations. This problem can be overcome by modeling selection probabilities simultaneously with other predictor–response relationships or by weighting observations by inverse selection probabilities. We illustrate the problem and a solution when modeling mixed migration strategies of northern white-tailed deer (Odocoileus virginianus). Captures occur on winter yards where deer migrate in response to changing environmental conditions. Yet, not all deer migrate in all years, and captures during mild years are more likely to target deer that migrate every year (i.e., obligate migrators). Characterizing deer as conditional or obligate migrators is also challenging unless deer are observed for many years and under a variety of winter conditions. We developed a hidden Markov model where the probability of capture depends on each individual's migration strategy (conditional versus obligate migrator), a partially latent variable that depends on winter severity in the year of capture. In a 15-year study, involving 168 white-tailed deer, the estimated probability of migrating for conditional migrators increased nonlinearly with an index of winter severity. We estimated a higher proportion of obligates in the study cohort than in the population, except during a span of 3 years surrounding back-to-back severe winters. These results support the hypothesis that selection biases occur as a result of capturing deer on winter yards, with the magnitude of bias depending on the severity of winter weather. Hidden Markov models offer an attractive framework for addressing selection biases due to their

  11. Establishing a Culture of Learning: A Mixed Methodology Exploration regarding the Phases of Change for Professional Learning Communities and Literacy Strategies

    ERIC Educational Resources Information Center

    Gray, James E.

    2010-01-01

    This research serves as a mixed methodological study that presents a conceptual framework which focuses on the relationship between professional learning communities, high yield literacy strategies, and their phases of change. As a result, the purpose of this study is threefold. First, a conceptual framework integrating professional learning…

  12. A Mixed Methods Study of Some of the Factors Associated with Successful School Strategies for Native Hawaiian Students in the State of Hawai'i

    ERIC Educational Resources Information Center

    Coryn, Chris L. S.; Schröter, Daniela C.; McCowen, Robert H.

    2014-01-01

    A concurrent mixed methods design, giving equal priority to both quantitative and qualitative methods, was used to investigate some of the factors that influence academic achievement of Native Hawaiian students in public schools in the state of Hawai'i. School-level instructional strategies, curricula, policies, and other variables that…

  13. Points of Convergence in Music Education: The Use of Data Labels as a Strategy for Mixed Methods Integration

    ERIC Educational Resources Information Center

    Fitzpatrick, Kate R.

    2016-01-01

    Although the mixing of quantitative and qualitative data is an essential component of mixed methods research, the process of integrating both types of data in meaningful ways can be challenging. The purpose of this article is to describe the use of data labels in mixed methods research as a technique for the integration of qualitative and…

  14. A cost-effective strategy for the bio-prospecting of mixed microalgae with high carbohydrate content: diversity fluctuations in different growth media.

    PubMed

    Cea-Barcia, Glenda; Buitrón, Germán; Moreno, Gloria; Kumar, Gopalakrishnan

    2014-07-01

    In recent years, widespread efforts have been directed towards decreasing the costs associated with microalgae culture systems for the production of biofuels. In this study, a simple and inexpensive strategy to bio-prospect and cultivate mixed indigenous chlorophytes with a high carbohydrate content for biomethane and biohydrogen production was developed. Mixed microalgae were collected from four different water-bodies in Queretaro, Mexico, and were grown in Bold's basal mineral medium and secondary effluent from a wastewater treatment plant using inexpensive photo-bioreactors. The results showed large fluctuations in microalgal genera diversity based on different culture media and nitrogen sources. In secondary effluent, Golenkinia sp. and Scenedesmus sp. proliferated. The carbohydrate content, for secondary effluent, varied between 12% and 57%, and the highest volumetric and areal productivity were 61 mg L(-1)d(-1) and 4.6 g m(-2)d(-1), respectively. These results indicate that mixed microalgae are a good feedstock for biomethane and biohydrogen production.

  15. Efficacy and Specific Effects Data on New Treatments: A Case Study Strategy with Mixed Anxiety-Depression.

    ERIC Educational Resources Information Center

    Moras, Karla; And Others

    1993-01-01

    Presents case study research strategy that can be used to develop new psychotherapeutic treatments, test theorized mechanisms of action, and obtain initial outcome data of type needed to support treatment outcome grant applications. Illustrates strategy by two case studies of new psychotherapeutic intervention for patients with coexisting…

  16. Summarizing EC50 estimates from multiple dose-response experiments: a comparison of a meta-analysis strategy to a mixed-effects model approach.

    PubMed

    Jiang, Xiaoqi; Kopp-Schneider, Annette

    2014-05-01

    Dose-response studies are performed to investigate the potency of a compound. EC50 is the concentration of the compound that gives half-maximal response. Dose-response data are typically evaluated by using a log-logistic model that includes EC50 as one of the model parameters. Often, more than one experiment is carried out to determine the EC50 value for a compound, requiring summarization of EC50 estimates from a series of experiments. In this context, mixed-effects models are designed to estimate the average behavior of EC50 values over all experiments by considering the variabilities within and among experiments simultaneously. However, fitting nonlinear mixed-effects models is more complicated than in a linear situation, and convergence problems are often encountered. An alternative strategy is the application of a meta-analysis approach, which combines EC50 estimates obtained from separate log-logistic model fitting. These two proposed strategies to summarize EC50 estimates from multiple experiments are compared in a simulation study and real data example. We conclude that the meta-analysis strategy is a simple and robust method to summarize EC50 estimates from multiple experiments, especially suited in the case of a small number of experiments.

  17. Ax(H3O)2-xMn5(HPO3)6 (A = Li, Na, K and NH4): open-framework manganese(ii) phosphites templated by mixed cationic species.

    PubMed

    Orive, Joseba; Fernández de Luis, Roberto; Fernández, Jesús Rodríguez; Lezama, Luis; Arriortua, María I

    2016-07-26

    Ax(H3O)2-xMn5(HPO3)6 (A = Li, x = 0.55 (1-Li); A = Na, x = 0.72 (2-Na); A = K, x = 0.30 (3-K); A = NH4, x = 0.59 (4-NH4)) phases were synthesized by employing mild hydrothermal conditions. 1-Li was studied by single crystal X-ray diffraction, while sodium, potassium and ammonium containing analogues were obtained as polycrystalline samples and characterized by powder X-ray diffraction. The four compounds were characterized by ICP-Q-MS, thermal analysis and XPS, IR, UV/Vis and EPR spectroscopy. Single crystal data indicate that 1-Li crystallizes in the P3[combining macron]c1 space group with lattice parameters a = 10.3764(1) Å and c = 9.4017(1) Å with Z = 2. The crystal structure of these phases is constituted by a three-dimensional [Mn(ii)5(HPO3)6](2-) anionic skeleton templated by alkali metal and ammonium cations together with protonated water molecules. Such an inorganic framework is formed by layers of edge-sharing MnO6 octahedra placed in the ab plane and joined along the c direction through phosphite pseudotetrahedra. The sheets display 12-membered ring channels parallel to the c-axis, ca. 5 Å in diameter, where the extraframework species display a strong disorder. EPR measurements point to the existence of short range ferromagnetic interactions around 12 K. Magnetic susceptibility and heat capacity measurements show that all the compounds exhibit long range antiferromagnetic order below circa 4 K, with a significant magnetocaloric effect around the Neel temperature.

  18. Bed mixing and leachate recycling strategies to overcome pressure drop buildup in the biofiltration of hydrogen sulfide.

    PubMed

    Roshani, Babak; Torkian, Ayoob; Aslani, Hasan; Dehghanzadeh, Reza

    2012-04-01

    The effects of leachate recycling and bed mixing on the removal rate of H(2)S from waste gas stream were investigated. The experimental setup consisted of an epoxy-coated three-section biofilter with an ID of 8 cm and effective bed height of 120 cm. Bed material consisted of municipal solid waste compost and PVC bits with an overall porosity of 54% and dry bulk density of 0.456 g cm(-3). Leachate recycling had a positive effect of increasing elimination capacity (EC) up to 21 g S m(-3) bed h(-1) at recycling rates of 75 ml d(-1), but in the bed mixing period EC declined to 8 g S m(-3) bed h(-1). Pressure drop had a range of zero to 18 mm H(2)O m(-1) in the course of leachate recycling. Accumulation of sulfur reduced removal efficiency and increased pressure drop up to 110 mm H(2)O m(-1) filter during the bed mixing stage.

  19. Mixed release of two parasitoids and a polyphagous ladybird as a potential strategy to control the tobacco whitefly Bemisia tabaci

    PubMed Central

    Tan, Xiaoling; Hu, Nana; Zhang, Fan; Ramirez-Romero, Ricardo; Desneux, Nicolas; Wang, Su; Ge, Feng

    2016-01-01

    A mixed species release of parasitoids is used to suppress outbreaks of tobacco whitefly, Bemisia tabaci (Hemiptera: Aleyrodidae); however, this biocontrol may be inhibited by interspecific interactions. We investigated the effects of mixed releases of natural enemies of B. tabaci on predation rates, parasite performance and adult parasitoid emergence under greenhouse conditions. We tested the polyphagous predatory ladybird Harmonia axyridis (Coleoptera: Coccinellidae) and two whitefly-specific parasitoids, namely Encarsia formosa and Encarsia sophia (both, Hymenoptera: Aphelinidae). Harmonia axyridis exhibited the lowest rates of predation when released with each parasitoid than with both parasitoid species together and showed a significant preference for non-parasitized nymphs as prey. Both E. formosa and E. sophia parasitized more B. tabaci when released with the ladybird than when the wasps were released either alone or mixed with the other parasitoid. We also found that the presence of H. axyridis significantly reduced adult parasitoid emergence; the highest rate of adult emergence was obtained with parasitoids released alone. Our results indicate that different combinations of natural enemies can influence observed rates of predation, parasitism, and parasitoid emergence. Therefore, the combination of natural enemies to be used for a particular biological control program should depend on the specific objectives. PMID:27312174

  20. Mixed-Metal Strategy on Metal-Organic Frameworks (MOFs) for Functionalities Expansion: Co Substitution Induces Aerobic Oxidation of Cyclohexene over Inactive Ni-MOF-74.

    PubMed

    Sun, Dengrong; Sun, Fangxiang; Deng, Xiaoyu; Li, Zhaohui

    2015-09-08

    Different amounts of Co-substituted Ni-MOF-74 have been prepared via a post-synthetic metal exchange. Inductively coupled plasma mass spectrometry, powder X-ray diffraction (XRD), N2 adsorption/desorption, and extended X-ray absorption fine structure (EXAFS) analyses indicated the successful metathesis between Co and Ni in Ni-MOF-74 to form the solid-solution-like mixed-metal Co/Ni-MOF-74. It was found that introduction of active Co into the Ni-MOF-74 framework enabled the inert Ni-MOF-74 to show activity for cyclohexene oxidation. Since Co was favorably substituted at positions more accessible to the substrate, the mixed-metal Co/Ni-MOF-74 showed superior catalytic performance, compared with pure Co-MOF-74 containing a similar amount of Co. This study provides a facile method to develop solid-solution-like MOFs for heterogeneous catalysis and highlights the great potential of this mixed-metal strategy in the development of MOFs with specific endowed functionalities.

  1. The Logic, Affectivity and Ethics of Electronic Conferencing Teaching Strategies in Post-Secondary Mixed-Mode Courses

    ERIC Educational Resources Information Center

    Campos, Milton

    2004-01-01

    This paper aims to identify and to understand the role of the logical, the affective and the ethical dimensions of knowledge in the online interactions of post-secondary teachers and students. By understanding how these dimensions are interwoven, I intend to demonstrate that the instructor?s course design and teaching strategies must take them…

  2. A novel fermentation strategy for removing the key inhibitor acetic acid and efficiently utilizing the mixed sugars from lignocellulosic hydrolysates

    SciTech Connect

    Mark A. Eiteman PHD; Elliot Altman Phd

    2009-02-11

    As part of preliminary research efforts, we have completed several experiments which demonstrate 'proof of concept.' These experiments addressed the following three questions: (1) Can a synthetic mixed sugar solution of glucose and xylose be efficiently consumed using the multi-organism approach? (2) Can this approach be used to accumulate a model product? (3) Can this approach be applied to the removal of an inhibitor, acetate, selectively from mixtures of xylose and glucose? To answer the question of whether this multi-organism approach can effectively consume synthetic mixed sugar solutions, we first tested substrate-selective uptake using two strains, one unable to consume glucose and one unable to consume xylose. The xylose-selective strain ALS998 has mutations in the three genes involved in glucose uptake, rendering it unable to consume glucose: ptsG codes for the Enzyme IICB{sup Glc} of the phosphotransferase system (PTS) for carbohydrate transport (Postma et al., 1993), manZ codes for the IID{sup Man} domain of the mannose PTS permease (Huber, 1996), glk codes for glucokinase (Curtis and Epstein 1975) We also constructed strain ALS1008 which has a knockout in the xylA gene encoding for xylose isomerase, rendering ALS1008 unable to consume xylose. Two batch experiments and one continuous bioprocess were completed. In the first experiment, each strain was grown separately in a defined medium of 8 g/L xylose and 15 g/L glucose which represented xylose and glucose concentrations that can be generated by actual biomass. In the second experiment, the two strains were grown together in batch in the same defined, mixed-sugar medium. In a third experiment, we grew the strains continuously in a 'chemostat', except that we shifted the concentrations of glucose and xylose periodically to observe how the system would respond. (For example, we shifted the glucose concentration suddenly from 15 g/L to 30 g/L in the feed).

  3. Strategies for efficiently selecting PHA producing mixed microbial cultures using complex feedstocks: Feast and famine regime and uncoupled carbon and nitrogen availabilities.

    PubMed

    Oliveira, Catarina S S; Silva, Carlos E; Carvalho, Gilda; Reis, Maria A

    2017-07-25

    Production of polyhydroxyalkanoates (PHAs) by open mixed microbial cultures (MMCs) has been attracting increasing interest as an alternative technology to PHA production by pure cultures, due to the potential for lower costs associated with the use of open systems (eliminating the requirement for sterile conditions) and the utilisation of cheap feedstock (industrial and agricultural wastes). Such technology relies on the efficient selection of an MMC enriched in PHA-accumulating organisms. Fermented cheese whey, a protein-rich complex feedstock, has been used previously to produce PHA using the feast and famine regime for selection of PHA accumulating cultures. While this selection strategy was found efficient when operated at relatively low organic loading rate (OLR, 2g-CODL(-1)d(-1)), great instability and low selection efficiency of PHA accumulating organisms were observed when higher OLR (ca. 6g-CODL(-1)d(-1)) was applied. High organic loading is desirable as a means to enhance PHA productivity. In the present study, a new selection strategy was tested with the aim of improving selection for high OLR. It was based on uncoupling carbon and nitrogen supply and was implemented and compared with the conventional feast and famine strategy. For this, two selection reactors were fed with fermented cheese whey applying an OLR of ca. 8.5g-CODL(-1) (with 3.8g-CODL(-1) resulting from organic acids and ethanol), and operated in parallel under similar conditions, except for the timing of nitrogen supplementation. Whereas in the conventional strategy nitrogen and carbon substrates were added simultaneously at the beginning of the cycle, in the uncoupled substrates strategy, nitrogen addition was delayed to the end of the feast phase (i.e. after exogenous carbon was exhausted). The two different strategies selected different PHA-storing microbial communities, dominated by Corynebacterium and a Xantomonadaceae, respectively with the conventional and the new approaches. The new

  4. Comparison of Different Strategies for Selection/Adaptation of Mixed Microbial Cultures Able to Ferment Crude Glycerol Derived from Second-Generation Biodiesel

    PubMed Central

    Varrone, C.; Heggeset, T. M. B.; Le, S. B.; Haugen, T.; Markussen, S.; Skiadas, I. V.; Gavala, H. N.

    2015-01-01

    Objective of this study was the selection and adaptation of mixed microbial cultures (MMCs), able to ferment crude glycerol generated from animal fat-based biodiesel and produce building-blocks and green chemicals. Various adaptation strategies have been investigated for the enrichment of suitable and stable MMC, trying to overcome inhibition problems and enhance substrate degradation efficiency, as well as generation of soluble fermentation products. Repeated transfers in small batches and fed-batch conditions have been applied, comparing the use of different inoculum, growth media, and Kinetic Control. The adaptation of activated sludge inoculum was performed successfully and continued unhindered for several months. The best results showed a substrate degradation efficiency of almost 100% (about 10 g/L glycerol in 21 h) and different dominant metabolic products were obtained, depending on the selection strategy (mainly 1,3-propanediol, ethanol, or butyrate). On the other hand, anaerobic sludge exhibited inactivation after a few transfers. To circumvent this problem, fed-batch mode was used as an alternative adaptation strategy, which led to effective substrate degradation and high 1,3-propanediol and butyrate production. Changes in microbial composition were monitored by means of Next Generation Sequencing, revealing a dominance of glycerol consuming species, such as Clostridium, Klebsiella, and Escherichia. PMID:26509171

  5. Impact of Patient and Procedure Mix on Finances of Perinatal Centres – Theoretical Models for Economic Strategies in Perinatal Centres

    PubMed Central

    Hildebrandt, T.; Kraml, F.; Wagner, S.; Hack, C. C.; Thiel, F. C.; Kehl, S.; Winkler, M.; Frobenius, W.; Faschingbauer, F.; Beckmann, M. W.; Lux, M. P.

    2013-01-01

    Introduction: In Germany, cost and revenue structures of hospitals with defined treatment priorities are currently being discussed to identify uneconomic services. This discussion has also affected perinatal centres (PNCs) and represents a new economic challenge for PNCs. In addition to optimising the time spent in hospital, the hospital management needs to define the “best” patient mix based on costs and revenues. Method: Different theoretical models were proposed based on the cost and revenue structures of the University Perinatal Centre for Franconia (UPF). Multi-step marginal costing was then used to show the impact on operating profits of changes in services and bed occupancy rates. The current contribution margin accounting used by the UPF served as the basis for the calculations. The models demonstrated the impact of changes in services on costs and revenues of a level 1 PNC. Results: Contribution margin analysis was used to calculate profitable and unprofitable DRGs based on average inpatient cost per day. Nineteen theoretical models were created. The current direct costing used by the UPF and a theoretical model with a 100 % bed occupancy rate were used as reference models. Significantly higher operating profits could be achieved by doubling the number of profitable DRGs and halving the number of less profitable DRGs. Operating profits could be increased even more by changing the rates of profitable DRGs per bed occupancy. The exclusive specialisation on pathological and high-risk pregnancies resulted in operating losses. All models which increased the numbers of caesarean sections or focused exclusively on c-sections resulted in operating losses. Conclusion: These theoretical models offer a basis for economic planning. They illustrate the enormous impact potential changes can have on the operating profits of PNCs. Level 1 PNCs require high bed occupancy rates and a profitable patient mix to cover the extremely high costs incurred due to the services

  6. Impact of Patient and Procedure Mix on Finances of Perinatal Centres - Theoretical Models for Economic Strategies in Perinatal Centres.

    PubMed

    Hildebrandt, T; Kraml, F; Wagner, S; Hack, C C; Thiel, F C; Kehl, S; Winkler, M; Frobenius, W; Faschingbauer, F; Beckmann, M W; Lux, M P

    2013-08-01

    Introduction: In Germany, cost and revenue structures of hospitals with defined treatment priorities are currently being discussed to identify uneconomic services. This discussion has also affected perinatal centres (PNCs) and represents a new economic challenge for PNCs. In addition to optimising the time spent in hospital, the hospital management needs to define the "best" patient mix based on costs and revenues. Method: Different theoretical models were proposed based on the cost and revenue structures of the University Perinatal Centre for Franconia (UPF). Multi-step marginal costing was then used to show the impact on operating profits of changes in services and bed occupancy rates. The current contribution margin accounting used by the UPF served as the basis for the calculations. The models demonstrated the impact of changes in services on costs and revenues of a level 1 PNC. Results: Contribution margin analysis was used to calculate profitable and unprofitable DRGs based on average inpatient cost per day. Nineteen theoretical models were created. The current direct costing used by the UPF and a theoretical model with a 100 % bed occupancy rate were used as reference models. Significantly higher operating profits could be achieved by doubling the number of profitable DRGs and halving the number of less profitable DRGs. Operating profits could be increased even more by changing the rates of profitable DRGs per bed occupancy. The exclusive specialisation on pathological and high-risk pregnancies resulted in operating losses. All models which increased the numbers of caesarean sections or focused exclusively on c-sections resulted in operating losses. Conclusion: These theoretical models offer a basis for economic planning. They illustrate the enormous impact potential changes can have on the operating profits of PNCs. Level 1 PNCs require high bed occupancy rates and a profitable patient mix to cover the extremely high costs incurred due to the services

  7. Intermittent control with ankle, hip, and mixed strategies during quiet standing: a theoretical proposal based on a double inverted pendulum model.

    PubMed

    Suzuki, Yasuyuki; Nomura, Taishin; Casadio, Maura; Morasso, Pietro

    2012-10-07

    Human upright posture, as a mechanical system, is characterized by an instability of saddle type, involving both stable and unstable dynamic modes. The brain stabilizes such system by generating active joint torques, according to a time-delayed neural feedback control. What is still unsolved is a clear understanding of the control strategies and the control mechanisms that are used by the central nervous system in order to stabilize the unstable posture in a robust way while maintaining flexibility. Most studies in this direction have been limited to the single inverted pendulum model, which is useful for formalizing fundamental mechanical aspects but insufficient for addressing more general issues concerning neural control strategies. Here we consider a double inverted pendulum model in the sagittal plane with small passive viscoelasticity at the ankle and hip joints. Despite difficulties in stabilizing the double pendulum model in the presence of the large feedback delay, we show that robust and flexible stabilization of the upright posture can be established by an intermittent control mechanism that achieves the goal of stabilizing the body posture according to a "divide and conquer strategy", which switches among different controllers in different parts of the state space of the double inverted pendulum. Remarkably, it is shown that a global, robust stability is achieved even if the individual controllers are unstable and the information exploited for switching from one controller to another is severely delayed, as it happens in biological reality. Moreover, the intermittent controller can automatically resolve coordination among multiple active torques associated with the muscle synergy, leading to the emergence of distinct temporally coordinated active torque patterns, referred to as the intermittent ankle, hip, and mixed strategies during quiet standing, depending on the passive elasticity at the hip joint.

  8. Adaptive Strategies and Person-Environment Fit among Functionally Limited Older Adults Aging in Place: A Mixed Methods Approach

    PubMed Central

    Lien, Laura L.; Steggell, Carmen D.; Iwarsson, Susanne

    2015-01-01

    Older adults prefer to age in place, necessitating a match between person and environment, or person-environment (P-E) fit. In occupational therapy practice, home modifications can support independence, but more knowledge is needed to optimize interventions targeting the housing situation of older adults. In response, this study aimed to explore the accessibility and usability of the home environment to further understand adaptive environmental behaviors. Mixed methods data were collected using objective and perceived indicators of P-E fit among 12 older adults living in community-dwelling housing. Quantitative data described objective P-E fit in terms of accessibility, while qualitative data explored perceived P-E fit in terms of usability. While accessibility problems were prevalent, participants’ perceptions of usability revealed a range of adaptive environmental behaviors employed to meet functional needs. A closer examination of the P-E interaction suggests that objective accessibility does not always stipulate perceived usability, which appears to be malleable with age, self-perception, and functional competency. Findings stress the importance of evaluating both objective and perceived indicators of P-E fit to provide housing interventions that support independence. Further exploration of adaptive processes in older age may serve to deepen our understanding of both P-E fit frameworks and theoretical models of aging well. PMID:26404352

  9. Co-occupant's exposure to exhaled pollutants with two types of personalized ventilation strategies under mixing and displacement ventilation systems.

    PubMed

    Li, X; Niu, J; Gao, N

    2013-04-01

    Personalized ventilation (PV) system in conjunction with total ventilation system can provide cleaner inhaled air for the user. Concerns still exist about whether the normally protecting PV device, on the other hand, facilitates the dispersion of infectious agents generated by its user. In this article, two types of PV systems with upward supplied fresh air, namely a chair-based PV and one kind of desk-mounted PV systems, when combined with mixing ventilation (MV) and displacement ventilation (DV) systems, are investigated using simulation method with regard to their impacts on co-occupant's exposure to the exhaled droplet nuclei generated by the infected PV user. Simulation results of tracer gas and particles with aerodynamic diameter of 1, 5, and 10 μm from exhaled air show that, when only the infected person uses a PV, the different PV air supplying directions present very different impacts on the co-occupant's intake under DV, while no apparent differences can be observed under MV. The findings demonstrate that better inhaled air quality can always be achieved under DV when the adopted PV system can deliver conditioned fresh air in the same direction with the mainly upward airflow patterns of DV.

  10. Adaptive Strategies and Person-Environment Fit among Functionally Limited Older Adults Aging in Place: A Mixed Methods Approach.

    PubMed

    Lien, Laura L; Steggell, Carmen D; Iwarsson, Susanne

    2015-09-23

    Older adults prefer to age in place, necessitating a match between person and environment, or person-environment (P-E) fit. In occupational therapy practice, home modifications can support independence, but more knowledge is needed to optimize interventions targeting the housing situation of older adults. In response, this study aimed to explore the accessibility and usability of the home environment to further understand adaptive environmental behaviors. Mixed methods data were collected using objective and perceived indicators of P-E fit among 12 older adults living in community-dwelling housing. Quantitative data described objective P-E fit in terms of accessibility, while qualitative data explored perceived P-E fit in terms of usability. While accessibility problems were prevalent, participants' perceptions of usability revealed a range of adaptive environmental behaviors employed to meet functional needs. A closer examination of the P-E interaction suggests that objective accessibility does not always stipulate perceived usability, which appears to be malleable with age, self-perception, and functional competency. Findings stress the importance of evaluating both objective and perceived indicators of P-E fit to provide housing interventions that support independence. Further exploration of adaptive processes in older age may serve to deepen our understanding of both P-E fit frameworks and theoretical models of aging well.

  11. Molecular tectonics of metal-organic frameworks (MOFs): a rational design strategy for unusual mixed-connected network topologies.

    PubMed

    Du, Miao; Zhang, Zhi-Hui; Tang, Liang-Fu; Wang, Xiu-Guang; Zhao, Xiao-Jun; Batten, Stuart R

    2007-01-01

    To systematically explore the higher-dimensional network structures with mixed connectivity, a series of two-dimensional (2D) and three-dimensional (3D) metal-organic frameworks (MOFs) with unusual (3,6)-connected net topologies are presented. These crystalline materials include [{[Mn(btza)2(H2O)2].2 H2O}n] (1), [{[Zn(btza)2(H2O)2].2 H2O}n] (2), [{[Cu(btza)2].H2O}n] (3), and [{[Cd(btza)2].3 H2O}n] (4), which have been successfully assembled through a predesigned three-connected organic component bis(1,2,4-triazol-1-yl)acetate (btza) with a variety of octahedral metal cores based on the modular synthetic methodology. The topological paradigms shown in this work cover the 2D CdCl2, 3D (4(2).6)2(4(4).6(2).8(7).10(2)), and pyrite (pyr) types. That is, when properly treated with the familiar first-row divalent metal ions, btza may perfectly furnish the coordination spheres for effective connectivity to result in diverse (3,6)-connected nets. Beyond this, a detailed analysis of network topology for all known 3D (3,6)-connected frameworks in both inorganic and inorganic-organic hybrid materials is described. Specific network connectivity of these MOFs indicates that the metal centers represent the most significant and alterable factor in structural assembly, although they show reliable and similar geometries. In this context, the combination of the distinct d10 AgI ion with btza in different solvents affords two isomorphous MOFs [{[Ag(btza)].glycol}n] (5) and [{[Ag(btza)]CH3OH}n] (6) with a binodal 4-connected 3D SrAl2 (sra) topology. The network structures of MOFs 1-3 and 5 turn out to be more complicated and interesting if one considers the hydrogen bonding between the host coordination frameworks and the intercalated solvent molecules. Furthermore, the role of the included solvents in the generation and stabilization of MOFs 1-6 is also investigated.

  12. Bluebelle study (phase A): a mixed-methods feasibility study to inform an RCT of surgical wound dressing strategies

    PubMed Central

    2016-01-01

    Objectives Dressing primary surgical wounds is common, but the implications for surgical site infection (SSI) remain unknown. The Bluebelle study aimed to determine the feasibility of a randomised controlled trial (RCT) comparing ‘simple’, ‘complex’ or ‘no’ dressings on abdominal wounds, as prespecified in a funder's research brief. Bluebelle includes exploratory work (phase A) to inform a pilot version of the proposed RCT (phase B). Phase A aimed to investigate current dressing practices and perspectives on the proposed RCT, with a view to refining the forthcoming pilot. Design Mixed methods, including semi-structured interviews and document analysis. Setting 6 UK hospitals. Participants 51 patients and 92 clinical professionals from abdominal surgical specialities. Results Professionals had variable interpretations of what constitutes a ‘dressing’, particularly with respect to ‘glue’—a product listed under ‘wound-closure products’ in the British National Formulary, which some surgeons reportedly applied as a ‘wound covering’. Areas of ambiguity arising from interviews informed development of pragmatic definitions, including specification of conditions under which glue constituted a ‘dressing’. Professionals reported that ‘simple’ dressings were routinely used in practice, whereas ‘complex’ dressings were not. This raised questions about the relevance of comparison groups, prompting the design of a survey to determine the types/frequency of dressing use in abdominal surgery (reported elsewhere). This confirmed that complex dressings were rarely used, while ‘glue as a dressing’ was used relatively frequently. ‘Complex dressings’ were therefore substituted for ‘glue as a dressing’ (following an updated Cochrane review, which found insufficient evidence to determine the effectiveness of ‘glue as a dressing’). Patients and professionals acknowledged uncertainty around dressing use and SSI prevention, but felt

  13. Effectiveness of a multiple-strategy community intervention to reduce maternal and child health inequalities in Haryana, North India: a mixed-methods study protocol

    PubMed Central

    Gupta, Madhu; Angeli, Federica; van Schayck, Onno C. P.; Bosma, Hans

    2015-01-01

    Background A multiple-strategy community intervention, known as National Rural Health Mission (NRHM), launched in India to improve the availability of and access to better-quality healthcare, especially for rural, poor mothers and children. The final goal of the intervention is to reduce maternal and child health inequalities across geographical areas, socioeconomic status groups, and sex of the child. Extensive, in-depth research is necessary to assess the effectiveness of NRHM, on multiple outcome dimensions. This paper presents the design of a new study, able to overcome the shortcomings of previous research. Objective To propose a comprehensive, methodologically sound protocol to assess the extent of implementation and the effectiveness of NRHM measures to improve maternal and child health outcomes and reduce maternal and child health inequalities. Design A mixed-methods approach (quantitative and qualitative) is proposed for this study in Haryana, a state in North India. NRHM's health sector plans included health system strengthening, specific maternal and child healthcare strategies, and communitization. Mission documents and reports on progress, financial monitoring, and common and joint review will be reviewed in-depth to assess the extent of the implementation of plans. Data on maternal and child health indicators will be obtained from demographic health surveys held before, during, and after the implementation of the first phase of the NRHM (2005–2012) and compared over time. Differences in maternal and child health indicators will be used to measure maternal and child health inequalities; these will be compared pre- and post-NRHM. Focus group discussions (FGDs) with service providers and in-depth interviews with program managers, community representatives, and mothers will be conducted until data saturation is achieved, in two districts of Haryana. Using Nvivo software, an inductive qualitative content analysis will be performed to search for the

  14. The Impact of Mediated Cognitive Strategies on the Reading Comprehension Performance and Self-Efficacy of Palestinian-Arab Middle School Students with LD: A Mixed-Methods Research

    ERIC Educational Resources Information Center

    Zayyad, Muhammad M.

    2009-01-01

    The purpose of this mixed-methods research was to examine the impact of mediated cognitive strategy intervention on the reading comprehension and self-efficacy of Palestinian-Arab middle school students with learning disabilities. Eighteen seventh-grade students with LD who were placed in two self-contained special education classrooms and their…

  15. Novel pH control strategy for efficient production of optically active l-lactic acid from kitchen refuse using a mixed culture system.

    PubMed

    Tashiro, Yukihiro; Inokuchi, Shota; Poudel, Pramod; Okugawa, Yuki; Miyamoto, Hirokuni; Miayamoto, Hisashi; Sakai, Kenji

    2016-09-01

    Uninvestigated control factors of meta-fermentation, the fermentative production of pure chemicals and fuels in a mixed culture system, were examined for production of optically pure l-lactic acid (LA) from food waste. In meta-fermentations by pH swing control, l-LA production with 100% optical purity (OPl-LA) was achieved even using unsterilized model kitchen refuse medium with preferential proliferation of l-LA-producing Bacillus coagulans, a minor member in the seed, whereas agitation decreased OPl-LA drastically. pH constant control shortened the fermentation time but decreased OPl-LA and LA selectivity (SLA) by stimulating growth of heterofermentative Bacillus thermoamylovorans. Deliberately switching from pH swing control to constant control exhibited the best performance for l-LA production: maximum accumulation, 39.2gL(-1); OPl-LA, 100%; SLA, 96.6%; productivity, 1.09gL(-1)h(-1). These results present a novel pH control strategy for efficient l-LA production in meta-fermentation based on a concept different from that of pure culture systems.

  16. Strategy towards cost-effective low-temperature solid oxide fuel cells: A mixed-conductive membrane comprised of natural minerals and perovskite oxide

    NASA Astrophysics Data System (ADS)

    Xia, Chen; Cai, Yixiao; Wang, Baoyuan; Afzal, Muhammad; Zhang, Wei; Soltaninazarlou, Aslan; Zhu, Bin

    2017-02-01

    Our previous work has revealed the feasibility of natural hematite as an electrolyte material for solid oxide fuel cells (SOFCs), tailoring SOFCs to be a more economically competitive energy conversion technology. In the present work, with the aim of exploring more practical uses of natural minerals, a novel composite hematite/LaCePrOx-La0.6Sr0.4Co0.2Fe0.8O3-δ (hematite/LCP-LSCF) has been developed from natural hematite ore, rare-earth mineral LaCePr-carbonate, and perovskite oxide LSCF as a functional membrane in SOFCs. The heterogeneity, nanostructure and mixed-conductive property of the composite were investigated. The results showed that the hematite/LCP-30 wt% LSCF composite possessed balanced ionic and electronic conductivities, with an ionic conductivity as high as 0.153 S cm-1 at 600 °C. The as-designed fuel cell using the hematite/LCP-LSCF membrane exhibited encouraging power outputs of 303 - 662 mW cm-2 at 500 - 600 °C. These findings show that the hematite/LCP-LSCF based fuel cell is a viable strategy for developing cost-effective and practical low-temperature SOFCs (LTSOFCs).

  17. A new mixed mode solid phase extraction strategy for opioids, cocaines, amphetamines and adulterants in human blood with hybrid liquid chromatography tandem mass spectrometry detection.

    PubMed

    Dowling, Geraldine; Regan, Liam

    2011-04-05

    A rapid method has been developed to analyse morphine, codeine, 6-monoacetylmorphine, cocaine, benzoylecgonine, dihydrocodeine, cocaethylene, 3,4-methylenedioxyamphetamine, ketamine, 3,4-methylenedioxymethamphetamine, pseudoephedrine, lignocaine, benzylpiperazine, methamphetamine, amphetamine, methadone, phenethylamine and levamisole in human blood. Blood samples were cleaned up using mixed mode solid phase extraction using Evolute™ CX solid phase extraction cartridges and the sample aliquots were analysed by hybrid triple quadrupole linear ion trap (QTRAP) mass spectrometry with a runtime of 12.5 min. Multiple reaction monitoring (MRM) as survey scan and an enhanced product ion (EPI) scan as dependent scan were performed in an information-dependent acquisition (IDA) experiment. Finally, drug identification and confirmation was carried out by library search with a developed in-house MS/MS library based on EPI spectra at a collision energy spread of 35 ± 15 in positive mode and MRM ratios. The method was validated in blood, according to the criteria defined in Commission Decision 2002/657/EC. At least two MRM transitions for each substance were monitored in addition to EPI spectra. Deuterated analogues of analytes were used as internal standards for quantitation where possible. The method proved to be simple and time efficient and was implemented as an analytical strategy for the illicit drug monitoring of opioids, cocaines, amphetamines and adulterants in forensic cases of crime offenders, abusers or victims in the Republic of Ireland.

  18. Mixing Strategies to Compare Fractions

    ERIC Educational Resources Information Center

    Tobias, Jennifer M.

    2014-01-01

    Strictly teaching algorithms or procedural computations can "encourage children to give up their own thinking" (Kamii and Dominick 1998). Although such procedures are valid for finding solutions, students often know only how to use them, and they lack the understanding of why a procedure works. In 2001, the National Research Council…

  19. Quality of life, coping strategies and support needs of women seeking Traditional Chinese Medicine for infertility and viable pregnancy in Australia: a mixed methods approach

    PubMed Central

    2013-01-01

    Background Infertility affects about 15% of couples in Western-societies with most progressing to fertility clinics for treatment. Despite being common, infertility is often experienced as a lonely road for affected couples. In this paper we expand on our previously published findings of women’s experiences with infertility or difficulty of viable pregnancy who had sought Traditional Chinese Medicine (TCM) therapy in Australia, and focus on women’s quality of life, coping strategies, and support needs. Methods We applied mixed methods using the Tuebingen Quality of Life and the COPE questionnaires and in-depth interviews with 25 women with primary or secondary infertility, recurrent miscarriages or unexplained stillbirth, and who had consulted a TCM practitioner. We used a thematic approach to analyse the interviews, and descriptive statistics to evaluate questionnaire responses. Results Women reported through both questionnaires and interviews compromised quality of life due to the high level of distress, guilt, grief, and frustration caused by infertility. However, our women represented a highly motivated sample, actively seeking alternative support. While the TCM approach to infertility management increased women’s sense of personal agency and control through education and continuity of care, the need for greater understanding and support on a societal level remains. Conclusions In infertility, ongoing emotional and instrumental support is pivotal to the wellbeing and quality of life of the affected. Traditional Chinese Medicine addresses some support needs in infertility not routinely available in the Western model of care. More peer-led and professional-led support groups are greatly needed for women experiencing infertility to help break isolation and raise awareness of integrative approaches to fertility management. PMID:23570255

  20. Perceptions and experiences of a gender gap at a Canadian research institute and potential strategies to mitigate this gap: a sequential mixed-methods study

    PubMed Central

    Mascarenhas, Alekhya; Moore, Julia E.; Tricco, Andrea C.; Hamid, Jemila; Daly, Caitlin; Bain, Julie; Jassemi, Sabrina; Kiran, Tara; Baxter, Nancy; Straus, Sharon E.

    2017-01-01

    Background: The gender gap in academia is long-standing. Failure to ensure that our academic faculty reflect our student pool and national population deprives Canada of talent. We explored the gender distribution and perceptions of the gender gap at a Canadian university-affiliated, hospital-based research institute. Methods: We completed a sequential mixed-methods study. In phase 1, we used the research institute's registry of scientists (1999-2014) and estimated overall prevalence of a gender gap and the gap with respect to job description (e.g., associate v. full-time) and research discipline. In phase 2, we conducted qualitative interviews to provide context for phase 1 data. Both purposive and snowball sampling were used for recruitment. Results: The institute included 30.1% (n = 62) women and 69.9% (n = 144) men, indicating a 39.8% gender gap. Most full-time scientists (60.3%, n = 70) were clinicians; there were 54.2% more male than female clinician scientists. Ninety-five percent of basic scientists were men, indicating a 90.5% gap. Seven key themes emerged from 21 interviews, including perceived impact of the gender gap, factors perceived to influence the gap, recruitment trends, presence of institutional support, mentorship and suggestions to mitigate the gap. Several factors were postulated to contribute to the gender gap, including unconscious bias in hiring. Interpretation: A substantial gender gap exists within this research institute. Participants identified strategies to address this gap, such as establishing transparent search processes, providing opportunities for informal networking and mentorship of female scientists and establishing institutional support for work-life balance.

  1. Mixing navigation on networks

    NASA Astrophysics Data System (ADS)

    Zhou, Tao

    2008-05-01

    In this article, we propose a mixing navigation mechanism, which interpolates between random-walk and shortest-path protocol. The navigation efficiency can be remarkably enhanced via a few routers. Some advanced strategies are also designed: For non-geographical scale-free networks, the targeted strategy with a tiny fraction of routers can guarantee an efficient navigation with low and stable delivery time almost independent of network size. For geographical localized networks, the clustering strategy can simultaneously increase efficiency and reduce the communication cost. The present mixing navigation mechanism is of significance especially for information organization of wireless sensor networks and distributed autonomous robotic systems.

  2. Comparison of Annie Sullivan's Teaching Strategies for Literacy and Communication to the Current Outcome Performance Indicators in Deaf-Blindness: An Exploratory Mixed-Methods Study

    ERIC Educational Resources Information Center

    Pevsner, Diane

    2010-01-01

    This study explored teaching strategies for communication and literacy development in deaf-blind students by determining if there was a significant relationship between the instructional strategies practiced by Annie Sullivan in the early 1900s and the contemporary instructional strategies recommended by The National Consortium on Deaf-Blindness…

  3. Deconstructing the complexity of substance use among young men who have sex with men (YMSM) by optimizing the role of qualitative strategies in a mixed methods study

    PubMed Central

    Kubicek, Katrina; Weiss, George; Iverson, Ellen F.; Kipke, Michele D.

    2010-01-01

    Qualitative data can be a powerful tool in developing interventions for substance use and other HIV-risk behaviors. Mixed-methods design offers researchers the ability to obtain data that provides both breadth and depth to their research. However, the integration of qualitative data in mixed-methods research has been limited. This paper describes the qualitative design of the Healthy Young Men’s Study, a longitudinal mixed-method study with an ethnically diverse cohort of young men who have sex with men (YMSM) (N=526) in Los Angeles. Integral to this discussion is how a mixed-methods study can address common challenges such as sampling, representation and integration. PMID:20222783

  4. Exploring Clinical Reasoning Strategies and Test-Taking Behaviors During Clinical Vignette Style Multiple-Choice Examinations: A Mixed Methods Study

    PubMed Central

    Heist, Brian Sanjay; Gonzalo, Jed David; Durning, Steven; Torre, Dario; Elnicki, David Michael

    2014-01-01

    Background Clinical vignette multiple-choice questions (MCQs) are widely used in medical education, but clinical reasoning (CR) strategies employed when approaching these questions have not been well described. Objectives The aims of the study were (1) to identify CR strategies and test-taking (TT) behaviors of physician trainees while solving clinical vignette MCQs; and (2) to examine the relationships between CR strategies and behaviors, and performance on a high-stakes clinical vignette MCQ examination. Methods Thirteen postgraduate year–1 level trainees completed 6 clinical vignette MCQs using a think-aloud protocol. Thematic analysis employing elements of grounded theory was performed on data transcriptions to identify CR strategies and TT behaviors. Participants' CR strategies and TT behaviors were then compared with their US Medical Licensing Examination Step 2 Clinical Knowledge scores. Results Twelve CR strategies and TT behaviors were identified. Individuals with low performance on Step 2 Clinical Knowledge demonstrated increased premature closure and increased faulty knowledge, and showed comparatively less ruling out of alternatives or admission of knowledge deficits. High performers on Step 2 Clinical Knowledge demonstrated increased ruling out of alternatives and admission of knowledge deficits, and less premature closure, faulty knowledge, or closure prior to reading the alternatives. Conclusions Different patterns of CR strategies and TT behaviors may be used by high and low performers during high-stakes clinical vignette MCQ examinations. PMID:26140123

  5. Examining Two Strategies to Link Mixed-Format Tests Using Multiple-Choice Anchors. Research Report. ETS RR-10-18

    ERIC Educational Resources Information Center

    Walker, Michael E.; Kim, Sooyeon

    2010-01-01

    This study examined the use of an all multiple-choice (MC) anchor for linking mixed format tests containing both MC and constructed-response (CR) items, in a nonequivalent groups design. An MC-only anchor could effectively link two such test forms if either (a) the MC and CR portions of the test measured the same construct, so that the MC anchor…

  6. DoD (Department of Defense) Advertising Mix Test. Comparison of Joint-Service with Service-Specific Strategies and Levels of Funding,

    DTIC Science & Technology

    1987-07-01

    34 % % . . BIBLIOGRAPHY Bayus, B.L. (1984) Word of Mouth and Marketing Strategy : A Model Integrating the Effects of Marketing Efforts and Personal Influences for One...restrictions) ,% - Marketing Strategies and Priorities (e.g. trade-offs betveen PS and UPS and sale and female accessions) - Enlistment Options (e.g...Series Analysis of Six Cereal Brands . Journal of Marketing Research. 19(Feb), 116-125. Ackoff, R.L. and J.R. Emshoff. 1975. Advertising Research at

  7. Mixed-Methods Research Methodologies

    ERIC Educational Resources Information Center

    Terrell, Steven R.

    2012-01-01

    Mixed-Method studies have emerged from the paradigm wars between qualitative and quantitative research approaches to become a widely used mode of inquiry. Depending on choices made across four dimensions, mixed-methods can provide an investigator with many design choices which involve a range of sequential and concurrent strategies. Defining…

  8. Mixed-mode, high-order multi-patterning control strategy with small-spot, optical CD metrology on device structures

    NASA Astrophysics Data System (ADS)

    Cramer, Hugo; Wisse, Baukje; Kruijswijk, Stefan; Theeuwes, Thomas; Song, Yi; Guo, Wei; Verma, Alok; Zhang, Rui; Chai, Yvon; Hsu, Sharon; Khandelwal, Rahul; Miceli, Giacomo; Welch, Steven; Sun, Kyu-Tae; Kim, Taeddy; Byun, Jin-Moo; Jung, Sang-Hoon; Seo, Moo-Young; Kim, Hyun-Sok; Park, Dong-Gyu; Jeong, Jong-Mun

    2016-03-01

    The high-NA angle-resolved scatterometer YieldStar 1250D, with a small 12x12μm2 inspection area, has been used to inspect CD variation After Develop (ADI) and After Partition/Final Etch (APEI/AFEI) on various layers and features of a HVM DRAM process. During recipe set-up, CD-SEM data were used to verify full recipe quality. The high sampling density enabled by the small inspection area and high speed of the YieldStar angle-resolved scatterometer could be used to reveal various kinds of CD variations. An intra-field control-loop with scanner dose corrections was tested, using very dense ADI and APEI measurements, 400ppf, 4fields. This strategy demonstrated a 21% improvement in intra-field CDU, in line with expectations from predictions. Inter-field control loops with different strategies have been simulated for APEI CD control. To capture all variations in the inter-field fingerprints a dense sampling, 24ppf full wafer, in combination with a dynamic, context-based control strategy, appeared to be necessary. An improvement of 30% of the wafer CDU (excluding the intra-field) is feasible. For the Self-Aligned Double Patterning process, essential for the dense DRAM cells, the CD variation at APEI contributes to pitch-walking at final etch. Pitch walking is an alternating OV error, therefore these control strategies will also contribute to improvement of the OV control budget.

  9. Optimized oral cholera vaccine distribution strategies to minimize disease incidence: A mixed integer programming model and analysis of a Bangladesh scenario.

    PubMed

    Smalley, Hannah K; Keskinocak, Pinar; Swann, Julie; Hinman, Alan

    2015-11-17

    In addition to improved sanitation, hygiene, and better access to safe water, oral cholera vaccines can help to control the spread of cholera in the short term. However, there is currently no systematic method for determining the best allocation of oral cholera vaccines to minimize disease incidence in a population where the disease is endemic and resources are limited. We present a mathematical model for optimally allocating vaccines in a region under varying levels of demographic and incidence data availability. The model addresses the questions of where, when, and how many doses of vaccines to send. Considering vaccine efficacies (which may vary based on age and the number of years since vaccination), we analyze distribution strategies which allocate vaccines over multiple years. Results indicate that, given appropriate surveillance data, targeting age groups and regions with the highest disease incidence should be the first priority, followed by other groups primarily in order of disease incidence, as this approach is the most life-saving and cost-effective. A lack of detailed incidence data results in distribution strategies which are not cost-effective and can lead to thousands more deaths from the disease. The mathematical model allows for what-if analysis for various vaccine distribution strategies by providing the ability to easily vary parameters such as numbers and sizes of regions and age groups, risk levels, vaccine price, vaccine efficacy, production capacity and budget.

  10. Mixed Dementia

    MedlinePlus

    ... with Lewy bodies , What Is Alzheimer's? NIA-Funded Memory & Aging Project Reveals Mixed Dementia Common Data from ... commonly with Alzheimer's disease. For example, in the Memory and Aging Project study involving long-term cognitive ...

  11. Interaction patterns between children and their teachers when using a specific multimedia and communication strategy: observations from children with autism and mixed intellectual disabilities.

    PubMed

    Tjus, T; Heimann, M; Nelson, K E

    2001-06-01

    This study reports on observed interaction patterns between 20 children with autism and mixed intellectual disabilities (mean chronological age = 11:4 years; language age = 4:7 years) and their nine teachers working with a specially developed multimedia program aiming to increase literacy skills. An increase in verbal expression was found over time for the total group. Children with autism also showed increased enjoyment and willingness to seek help from their teachers. Teachers for both diagnostic groups reduced their instructions on how to handle the computer during the program but the decrease was greater in the teachers for children with autism. When the total group of children was subdivided according to language age (high versus low), it appears that those with a low language age showed an increase in verbal expressiveness from start to end of training. Those with a high language age showed increased enjoyment. It is concluded that more detailed studies of the interaction patterns between teachers and children are needed, and these should be related to children's language level as well as to diagnostic group.

  12. Mixed-methods study identifies key strategies for improving infant and young child feeding practices in a highly stunted rural indigenous population in Guatemala.

    PubMed

    Brown, Kelley; Henretty, Nicole; Chary, Anita; Webb, Meghan Farley; Wehr, Heather; Moore, Jillian; Baird, Caitlin; Díaz, Anne Kraemer; Rohloff, Peter

    2016-04-01

    Guatemala's rural indigenous population suffers from one of the highest rates of chronic child malnutrition (stunting) in the world. Successfully addressing stunting requires defining the barriers to and opportunities for new behaviour-change initiatives. We undertook a mixed-methods assessment of feeding practices and food purchasing behaviours around infants and young children aged 6-36 months in two rural indigenous Guatemalan communities. We found that most caregivers were aware only of acute forms of child malnutrition and that they greatly underestimated the local prevalence of malnutrition. Despite moderate adherence to exclusive breastfeeding and timing of complementary food introduction, diets had poor diversity and inadequate meal frequency. Furthermore, perceptions of food insecurity were high even in the presence of land ownership and agricultural production. Although fortified foods were highly valued, they were considered expensive. At the same time, proportionally equivalent amounts of money were spent on junk foods or other processed foods by most participants. Biological mothers often lacked autonomy for food purchasing and nutritional decisions because of the power exerted by husbands and paternal grandmothers. Our findings suggest several creative and community-based programming initiatives including education about the acute vs. chronic malnutrition distinction, engaging landowners in discussions about domestic food consumption, engaging with caregivers to redirect funds towards fortified foods rather than junk food purchases and directing behaviour-change initiatives towards all household stakeholders.

  13. A belief-based evolutionarily stable strategy.

    PubMed

    Deng, Xinyang; Wang, Zhen; Liu, Qi; Deng, Yong; Mahadevan, Sankaran

    2014-11-21

    As an equilibrium refinement of the Nash equilibrium, evolutionarily stable strategy (ESS) is a key concept in evolutionary game theory and has attracted growing interest. An ESS can be either a pure strategy or a mixed strategy. Even though the randomness is allowed in mixed strategy, the selection probability of pure strategy in a mixed strategy may fluctuate due to the impact of many factors. The fluctuation can lead to more uncertainty. In this paper, such uncertainty involved in mixed strategy has been further taken into consideration: a belief strategy is proposed in terms of Dempster-Shafer evidence theory. Furthermore, based on the proposed belief strategy, a belief-based ESS has been developed. The belief strategy and belief-based ESS can reduce to the mixed strategy and mixed ESS, which provide more realistic and powerful tools to describe interactions among agents.

  14. Ion mixing

    NASA Technical Reports Server (NTRS)

    Matteson, S.; Nicolet, M.-A.

    1983-01-01

    Recent experimental studies of the ion-mixing phenomenon are summarized. Ion mixing is differentiated from ion implantation and shown to be a useful technique for overcoming the sputter-dependent limitations of implantation processes. The fundamental physical principles of ion/solid interactions are explored. The basic experimental configurations currently in use are characterized: bilayered samples, multilayered samples, and samples with a thin marker layer. A table listing the binary systems (metal-semiconductor or metal-metal) which have been investigated using each configuration is presented. Results are discussed, and some sample data are plotted. The prospects for future application of ion mixing to the alteration of solid surface properties are considered. Practical applications are seen as restricted by economic considerations to the production of small, expensive components or to fields (such as the semiconductor industry) which already have facilities for ion implantation.

  15. Lateral Mixing

    DTIC Science & Technology

    2013-09-30

    apl.uw.edu/dasaro LONG-TERM GOALS I seek to understand the processes controlling lateral mixing in the ocean, particularly at the submesoscale ...APPROACH During AESOP, Lee and D’Asaro pioneered an innovative approach to measuring submesoscale structure in strong fronts. An adaptive measurement...injection of potential vorticity and scalars is predicted to create an intense ‘ submesoscale soup’ of high small-scale variance. The combination of small

  16. Lateral Mixing

    DTIC Science & Technology

    2012-11-08

    to mesoscale forcing. APPROACH Figure 1: MVP system deployed from stern of R/V Endeavor in Sargasso Sea . 1 DISTRIBUTION STATEMENT A. Approved for...integrative efforts with other sea -going investigators and numerical modelers. The Lateral Mixing Experiment project was an ideal opportunity to...2011 I also participated in the sea -going part of this project, taking my group on the R/V Endeavor in June 2011. Our role was to sample around the

  17. Lateral Mixing

    DTIC Science & Technology

    2011-09-30

    ocean as it responds to mesoscale forcing. APPROACH Figure 1: MVP system deployed from stern of R/V Endeavor in Sargasso Sea . My approach for...therefore requires integrative efforts with other sea -going investigators and numerical modelers. The Lateral Mixing Experiment project was an ideal...also participated in the sea -going part of this project, taking my group on the R/V Endeavor in June 2011. Our role was to sample around the center of

  18. Mixing in polymeric microfluidic devices.

    SciTech Connect

    Schunk, Peter Randall; Sun, Amy Cha-Tien; Davis, Robert H.; Brotherton, Christopher M. (University of Colorado at Boulder, Boulder, CO)

    2006-04-01

    This SAND report describes progress made during a Sandia National Laboratories sponsored graduate fellowship. The fellowship was funded through an LDRD proposal. The goal of this project is development and characterization of mixing strategies for polymeric microfluidic devices. The mixing strategies under investigation include electroosmotic flow focusing, hydrodynamic focusing, physical constrictions and porous polymer monoliths. For electroosmotic flow focusing, simulations were performed to determine the effect of electroosmotic flow in a microchannel with heterogeneous surface potential. The heterogeneous surface potential caused recirculations to form within the microchannel. These recirculations could then be used to restrict two mixing streams and reduce the characteristic diffusion length. Maximum mixing occurred when the ratio of the mixing region surface potential to the average channel surface potential was made large in magnitude and negative in sign, and when the ratio of the characteristic convection time to the characteristic diffusion time was minimized. Based on these results, experiments were performed to evaluate the manipulation of surface potential using living-radical photopolymerization. The material chosen to manipulate typically exhibits a negative surface potential. Using living-radical surface grafting, a positive surface potential was produced using 2-(Dimethylamino)ethyl methacrylate and a neutral surface was produced using a poly(ethylene glycol) surface graft. Simulations investigating hydrodynamic focusing were also performed. For this technique, mixing is enhanced by using a tertiary fluid stream to constrict the two mixing streams and reduce the characteristic diffusion length. Maximum mixing occurred when the ratio of the tertiary flow stream flow-rate to the mixing streams flow-rate was maximized. Also, like the electroosmotic focusing mixer, mixing was also maximized when the ratio of the characteristic convection time to the

  19. MISO - Mixed Integer Surrogate Optimization

    SciTech Connect

    Mueller, Juliane

    2016-01-20

    MISO is an optimization framework for solving computationally expensive mixed-integer, black-box, global optimization problems. MISO uses surrogate models to approximate the computationally expensive objective function. Hence, derivative information, which is generally unavailable for black-box simulation objective functions, is not needed. MISO allows the user to choose the initial experimental design strategy, the type of surrogate model, and the sampling strategy.

  20. OH-6A Propulsion System Vibration Investigation

    DTIC Science & Technology

    1975-01-01

    element structural model of the OH-6A helicopter . The NASTRAN computer program (mentioned in Reference 4) was used for the airframe. The...sort. For this program, a NASTRAN model of the OH-6A helicopter was prepared. (See Reference 12.) The participants in this research project...Corporation, planned and supervised the preparation of the NASTRAN model of the airframe and engine used in this study. Acknowledgment is made of

  1. A Mixed Methods Sampling Methodology for a Multisite Case Study

    ERIC Educational Resources Information Center

    Sharp, Julia L.; Mobley, Catherine; Hammond, Cathy; Withington, Cairen; Drew, Sam; Stringfield, Sam; Stipanovic, Natalie

    2012-01-01

    The flexibility of mixed methods research strategies makes such approaches especially suitable for multisite case studies. Yet the utilization of mixed methods to select sites for these studies is rarely reported. The authors describe their pragmatic mixed methods approach to select a sample for their multisite mixed methods case study of a…

  2. Mixed messages

    PubMed Central

    Chen, Christopher B.; Hall, Kevin; Tsuyuki, Ross T.

    2014-01-01

    Background: More than 5 years ago, the Blueprint for Pharmacy developed a plan for transitioning pharmacy practice toward more patient-centred care. Much of the strategy for change involves communicating the new vision. Objective: To evaluate the communication of the Vision for Pharmacy by the organizations and corporations that signed the Blueprint for Pharmacy’s Commitment to Act. Methods: The list of 88 signatories of the Commitment to Act was obtained from the Blueprint for Pharmacy document. The website of each of these signatories was searched for all references to the Blueprint for Pharmacy or Vision for Pharmacy. Each of the identified references was then analyzed using summative content analysis. Results: A total of 934 references were identified from the webpages of the 88 signatories. Of these references, 549 were merely links to the Blueprint for Pharmacy’s website, 350 of the references provided some detailed information about the Blueprint for Pharmacy and only 35 references provided any specific plans to transition pharmacy practice. Conclusion: Widespread proliferation of the Vision for Pharmacy has not been achieved. One possible explanation for this is that communication of the vision by the signatories has been incomplete. To ensure the success of future communications, change leaders must develop strategies that consider how individual pharmacists and pharmacies understand the message. PMID:24660012

  3. Mixed cryoglobulinemia

    PubMed Central

    Ferri, Clodoveo

    2008-01-01

    Mixed cryoglobulinemia (MC), type II and type III, refers to the presence of circulating cryoprecipitable immune complexes in the serum and manifests clinically by a classical triad of purpura, weakness and arthralgias. It is considered to be a rare disorder, but its true prevalence remains unknown. The disease is more common in Southern Europe than in Northern Europe or Northern America. The prevalence of 'essential' MC is reported as approximately 1:100,000 (with a female-to-male ratio 3:1), but this term is now used to refer to a minority of MC patients only. MC is characterized by variable organ involvement including skin lesions (orthostatic purpura, ulcers), chronic hepatitis, membranoproliferative glomerulonephritis, peripheral neuropathy, diffuse vasculitis, and, less frequently, interstitial lung involvement and endocrine disorders. Some patients may develop lymphatic and hepatic malignancies, usually as a late complication. MC may be associated with numerous infectious or immunological diseases. When isolated, MC may represent a distinct disease, the so-called 'essential' MC. The etiopathogenesis of MC is not completely understood. Hepatitis C virus (HCV) infection is suggested to play a causative role, with the contribution of genetic and/or environmental factors. Moreover, MC may be associated with other infectious agents or immunological disorders, such as human immunodeficiency virus (HIV) infection or primary Sjögren's syndrome. Diagnosis is based on clinical and laboratory findings. Circulating mixed cryoglobulins, low C4 levels and orthostatic skin purpura are the hallmarks of the disease. Leukocytoclastic vasculitis involving medium- and, more often, small-sized blood vessels is the typical pathological finding, easily detectable by means of skin biopsy of recent vasculitic lesions. Differential diagnoses include a wide range of systemic, infectious and neoplastic disorders, mainly autoimmune hepatitis, Sjögren's syndrome, polyarthritis, and B

  4. Restoration of senescence in breast and ovarian cancer cells following the transfer of the YAC carrying SEN6A gene located at 6q16.3.

    PubMed

    Rane, Neena S; Sandhu, Arbansjit K; Zhawar, Vikramjit S; Kaur, Gurpreet; Popescu, Nicholas C; Kandpal, Raj P; Jhanwar-Uniyal, Meena; Athwal, Raghbir S

    2011-01-01

    We previously located a senescence gene locus (SEN6A), at chromosome 6q14-21 by a functional strategy using chromosome transfer into immortal ovarian tumor cells. To further elucidate the SEN6A locus, intact chromosome 6 or 6q was transferred into rat ovarian tumor cells and a panel of immortal revertant clones of senescent cells was generated. The panel of independent colonies as well as mixed populations of revertant cells was analyzed for the presence or absence of chromosome 6 specific markers. These investigations led to the identification of a fine deletion of approximately 1cM at chromosomal interval 6q16.3. A contiguous stretch containing five yeast artificial chromosome (YAC) clones was constructed across the deleted region. The non-chimeric YAC clones were retrofitted and transferred into mouse A9 cells by spheroplast fusion to generate YAC/A9 hybrids. YAC DNA present in YAC/A9 hybrids was subsequently transferred by microcell fusion into immortal tumor cells, and the hybrid cells were characterized for their senescence phenotype. Using this functional strategy, the transfer of YAC clone 966b10 was shown to restore senescence in both rat and human ovarian and breast tumor cells. Our results demonstrate that the SEN6A gene is carried on a 1 Mb YAC, 966b10, which maps at 6q16.3.

  5. “I don't want them to feel different”: A mixed methods study of parents’ beliefs and dietary management strategies for their young child with type 1 diabetes mellitus

    PubMed Central

    Patton, Susana R.; Clements, Mark A.; George, Katie; Goggin, Kathy

    2015-01-01

    Background Many young children with type 1 diabetes (T1DM) do not consume a healthful diet; exactly why this occurs despite T1DM education remains poorly understood. Objective This study describes parents’ perceptions of healthful eating for T1DM in young children and identifies factors related to parents’ dietary management. Design A cross-sectional, mixed-methods study was performed. Parents completed a questionnaire, three-day weighed diet record, and a semi-structured interview regarding their perceptions of healthful eating for T1DM and their dietary management practices. Participants/setting Twenty-three families, recruited from a Pediatric Diabetes Clinic in the Mid-Western United States between February 2012 and April 2013, participated. Eligible families had a child with T1DM who was 1-6 years old, at least six months from diagnosis, and was following an intensive insulin regimen. Statistical analyses performed Mean scores and percentages were calculated from the diet diaries and parent questionnaires, while parents’ interviews were coded to identify common themes. Results Results showed that while parents may believe they know what constitutes a healthful diet for T1DM, they do not always feed their child a healthful diet. Parent-identified barriers to healthful eating included: limited time to prepare homemade meals, perceived higher costs of healthier foods, the influence of peers on children's food preferences, and picky eating. Parents also discussed a desire not to limit their child's diet or make their child “feel different”, which many parents said often led them to give into child's requests for less healthful food options. Conclusions Parents of young children with T1DM identified several barriers to healthful eating that are common for all parents, such as time constraints, expense, and child food preferences. However, unique themes emerged including parents’ desire not to limit their child's diet or make their child

  6. Mixing in astrophysics

    SciTech Connect

    Fryer, Christopher Lee

    2011-01-07

    Turbulent mixing plays a vital role in many fields in astronomy. Here I review a few of these sites, discuss the importance of this turbulent mixing and the techniques used by astrophysicists to solve these problems.

  7. Mixing in explosions

    SciTech Connect

    Kuhl, A.L.

    1993-12-01

    Explosions always contain embedded turbulent mixing regions, for example: boundary layers, shear layers, wall jets, and unstable interfaces. Described here is one particular example of the latter, namely, the turbulent mixing occurring in the fireball of an HE-driven blast wave. The evolution of the turbulent mixing was studied via two-dimensional numerical simulations of the convective mixing processes on an adaptive mesh. Vorticity was generated on the fireball interface by baroclinic effects. The interface was unstable, and rapidly evolved into a turbulent mixing layer. Four phases of mixing were observed: (1) a strong blast wave phase; (2) and implosion phase; (3) a reshocking phase; and (4) an asymptotic mixing phase. The flowfield was azimuthally averaged to evaluate the mean and r.m.s. fluctuation profiles across the mixing layer. The vorticity decayed due to a cascade process. This caused the corresponding enstrophy parameter to increase linearly with time -- in agreement with homogeneous turbulence calculations of G.K. Batchelor.

  8. Mixed methods research.

    PubMed

    Halcomb, Elizabeth; Hickman, Louise

    2015-04-08

    Mixed methods research involves the use of qualitative and quantitative data in a single research project. It represents an alternative methodological approach, combining qualitative and quantitative research approaches, which enables nurse researchers to explore complex phenomena in detail. This article provides a practical overview of mixed methods research and its application in nursing, to guide the novice researcher considering a mixed methods research project.

  9. Regulatory Role of N(6) -Methyladenosine (m(6) A) Methylation in RNA Processing and Human Diseases.

    PubMed

    Wei, Wenqiang; Ji, Xinying; Guo, Xiangqian; Ji, Shaoping

    2017-03-03

    N(6) -methyladenosine (m(6) A) modification is an abundant and conservative RNA modification in bacterial and eukaryotic cells. m(6) A modification mainly occurs in the 3' untranslated regions (UTRs) and near the stop codons of mRNA. Diverse strategies have been developed for identifying m(6) A sites in single nucleotide resolution. Dynamic regulation of m(6) A is found in metabolism, embryogenesis and developmental processes, indicating a possible epigenetic regulation role along RNA processing and exerting biological functions. It has been known that m(6) A editing involves in nuclear RNA export, mRNA degradation, protein translation and RNA splicing. Deficiency of m(6) A modification will lead to kinds of diseases, such as obesity, cancer, type 2 diabetes mellitus, infertility, developmental arrest. Some specific inhibitors against methyltransferase and demethylase have been developed to selectively regulate m(6) A modification, which may be advantageous for treatment of m(6) A related diseases. This article is protected by copyright. All rights reserved.

  10. Human herpesvirus 6A (HHV-6A) exhibits restrictive propagation with limited activation of PKR-eIF2α stress pathway.

    PubMed

    Sharon, Eyal; Frenkel, Niza

    2017-02-15

    The eIF2α protein plays a critical role in the regulation of translation. The production of dsRNA during viral replication can activate protein kinase R (PKR) which phosphorylates the eIF2α, leading to inhibition of the initial step of translation. Many viruses have evolved gene products targeting PKR-eIF2a pathway, indicating its importance in antiviral defense. In the present study we focus on alternations of PKR-eIF2a pathway along HHV-6A infection while monitoring viral gene expression and infectious viral yields. We have found increased phosphorylated PKR as well as phosphorylated eIF2α coincidental with accumulation of the late gp82-105 viral protein. The level of total PKR was relatively constant, but it decreased by 144 hours post infection. The phosphorylation of eIF2a led to a moderate increase in ATF4 accumulation, indicating moderate inhibition of protein translation during HHV-6A infection. The overexpression of PKR led to decreased viral propagation coincidental with increased accumulation of phosphorylated PKR and phosphorylated eIF2a. Moreover, addition of dominant-negative PKR mutant resulted in a moderate increase in viral replication. HHV-6A exhibits relatively low propagation efficiency of progeny virus secreted into the culture media. This study suggests that the replicative strategy of HHV-6A involves a mild infection over lengthy life cycle in culture, while preventing severe activation of the PKR-eIF2α pathway.IMPORTANCE Human herpesvirus 6A (HHV-6A) and HHV-6B are common, wildly prevalent viruses, causing from mild to severe disease. Our study focuses on the PKR-eIF2α stress pathway that limits viral replication. The HHV-6 genome encodes multiple genes transcribed from the two strands predicting accumulation of dsRNAs which can activates PKR and inhibition of protein synthesis. We report that HHV-6A induced the accumulation of phosphorylated PKR, phosphorylated eIF2α and a moderate increase of the activating transcription factor 4

  11. Applying Mixed Methods Techniques in Strategic Planning

    ERIC Educational Resources Information Center

    Voorhees, Richard A.

    2008-01-01

    In its most basic form, strategic planning is a process of anticipating change, identifying new opportunities, and executing strategy. The use of mixed methods, blending quantitative and qualitative analytical techniques and data, in the process of assembling a strategic plan can help to ensure a successful outcome. In this article, the author…

  12. Neutrino mass and mixing with discrete symmetry.

    PubMed

    King, Stephen F; Luhn, Christoph

    2013-05-01

    This is a review paper about neutrino mass and mixing and flavour model building strategies based on discrete family symmetry. After a pedagogical introduction and overview of the whole of neutrino physics, we focus on the PMNS mixing matrix and the latest global fits following the Daya Bay and RENO experiments which measure the reactor angle. We then describe the simple bimaximal, tri-bimaximal and golden ratio patterns of lepton mixing and the deviations required for a non-zero reactor angle, with solar or atmospheric mixing sum rules resulting from charged lepton corrections or residual trimaximal mixing. The different types of see-saw mechanism are then reviewed as well as the sequential dominance mechanism. We then give a mini-review of finite group theory, which may be used as a discrete family symmetry broken by flavons either completely, or with different subgroups preserved in the neutrino and charged lepton sectors. These two approaches are then reviewed in detail in separate chapters including mechanisms for flavon vacuum alignment and different model building strategies that have been proposed to generate the reactor angle. We then briefly review grand unified theories (GUTs) and how they may be combined with discrete family symmetry to describe all quark and lepton masses and mixing. Finally, we discuss three model examples which combine an SU(5) GUT with the discrete family symmetries A₄, S₄ and Δ(96).

  13. Managing livestock using animal behavior: Mixed-species stocking and flerds

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Mixed-species stocking can foster sound landscape management while offering economic and ecological advantages compared to mono-species stocking. Producers contemplating a mixed-species enterprise should reflect on several considerations before implementing this animal management strategy. Factors...

  14. Mixed oxide solid solutions

    DOEpatents

    Magno, Scott; Wang, Ruiping; Derouane, Eric

    2003-01-01

    The present invention is a mixed oxide solid solution containing a tetravalent and a pentavalent cation that can be used as a support for a metal combustion catalyst. The invention is furthermore a combustion catalyst containing the mixed oxide solid solution and a method of making the mixed oxide solid solution. The tetravalent cation is zirconium(+4), hafnium(+4) or thorium(+4). In one embodiment, the pentavalent cation is tantalum(+5), niobium(+5) or bismuth(+5). Mixed oxide solid solutions of the present invention exhibit enhanced thermal stability, maintaining relatively high surface areas at high temperatures in the presence of water vapor.

  15. Cement mixing with vibrator

    SciTech Connect

    Allen, T.E.

    1991-07-09

    This patent describes a method of cementing a casing string in a bore hole of a well. It comprises introducing water and dry cement material into a mixing vessel; mixing the water and dry cement material in the mixing vessel to form a cement slurry, the slurry including lumps of the dry cement material, the mixing including steps of: agitating the slurry; and while agitating the slurry, transmitting vibrational energy into the slurry and thereby aiding disintegration and subsequent wetting of the lumps of the dry cement material in the slurry; and pumping the slurry into an annulus between the casing string and the bore hole.

  16. Mixed waste minimization/mixed waste avoidance

    SciTech Connect

    Todisco, L.R.

    1994-12-31

    This presentation describes methods for the minimization and volume reduction of low-level radioactive and mixed wastes. Many methods are presented including: source reduction, better waste monitoring activities, waste segregation, recycling, administrative controls, and optimization of waste-generating processes.

  17. Dilution Zone Mixing

    NASA Technical Reports Server (NTRS)

    Holdeman, J. D.

    1983-01-01

    Studies to characterize dilution zone mixing; experiments on the effects of free-stream turbulence on a jet in crossflow; and the development of an interactive computer code for the analysis of the mixing of jets with a confined crossflow are reviewed.

  18. MHD turbulent mixing layers

    SciTech Connect

    Esquivel, A.; Lazarian, A.; Benjamin, R.A.; Cho, J.; Leitner, S.N.

    2005-09-28

    Turbulent mixing layers have been proposed to explain observations of line ratios of highly ionized elements in the interstellar medium. We present preliminary results of numerical simulations of turbulent mixing layers in a magnetized medium. We developed a MHD code with radiative cooling. The magnetic field is expected to be a controlling factor by suppressing instabilities that lead to the turbulent mixing. Our results suggest that the difference in turbulent mixing in the unmagnetized case as compared to the case of a weak magnetic field, {beta} = Pgas/Pmag {approx} 10, is insignificant. With a more thorough exploration of parameter space, this work will provide more reliable diagnostics of turbulent mixing layers than those available today.

  19. Microfluidic Mixing: A Review

    PubMed Central

    Lee, Chia-Yen; Chang, Chin-Lung; Wang, Yao-Nan; Fu, Lung-Ming

    2011-01-01

    The aim of microfluidic mixing is to achieve a thorough and rapid mixing of multiple samples in microscale devices. In such devices, sample mixing is essentially achieved by enhancing the diffusion effect between the different species flows. Broadly speaking, microfluidic mixing schemes can be categorized as either “active”, where an external energy force is applied to perturb the sample species, or “passive”, where the contact area and contact time of the species samples are increased through specially-designed microchannel configurations. Many mixers have been proposed to facilitate this task over the past 10 years. Accordingly, this paper commences by providing a high level overview of the field of microfluidic mixing devices before describing some of the more significant proposals for active and passive mixers. PMID:21686184

  20. Recent advances in dynamic m6A RNA modification

    PubMed Central

    Cao, Guangchao; Yin, Zhinan

    2016-01-01

    The identification of m6A demethylases and high-throughput sequencing analysis of methylated transcriptome corroborated m6A RNA epigenetic modification as a dynamic regulation process, and reignited its investigation in the past few years. Many basic concepts of cytogenetics have been revolutionized by the growing understanding of the fundamental role of m6A in RNA splicing, degradation and translation. In this review, we summarize typical features of methylated transcriptome in mammals, and highlight the ‘writers’, ‘erasers’ and ‘readers’ of m6A RNA modification. Moreover, we emphasize recent advances of biological functions of m6A and conceive the possible roles of m6A in the regulation of immune response and related diseases. PMID:27249342

  1. ADVANCED MIXING MODELS

    SciTech Connect

    Lee, S; Richard Dimenna, R; David Tamburello, D

    2008-11-13

    The process of recovering the waste in storage tanks at the Savannah River Site (SRS) typically requires mixing the contents of the tank with one to four dual-nozzle jet mixers located within the tank. The typical criteria to establish a mixed condition in a tank are based on the number of pumps in operation and the time duration of operation. To ensure that a mixed condition is achieved, operating times are set conservatively long. This approach results in high operational costs because of the long mixing times and high maintenance and repair costs for the same reason. A significant reduction in both of these costs might be realized by reducing the required mixing time based on calculating a reliable indicator of mixing with a suitably validated computer code. The work described in this report establishes the basis for further development of the theory leading to the identified mixing indicators, the benchmark analyses demonstrating their consistency with widely accepted correlations, and the application of those indicators to SRS waste tanks to provide a better, physically based estimate of the required mixing time. Waste storage tanks at SRS contain settled sludge which varies in height from zero to 10 ft. The sludge has been characterized and modeled as micron-sized solids, typically 1 to 5 microns, at weight fractions as high as 20 to 30 wt%, specific gravities to 1.4, and viscosities up to 64 cp during motion. The sludge is suspended and mixed through the use of submersible slurry jet pumps. To suspend settled sludge, water is added to the tank as a slurry medium and stirred with the jet pump. Although there is considerable technical literature on mixing and solid suspension in agitated tanks, very little literature has been published on jet mixing in a large-scale tank. If shorter mixing times can be shown to support Defense Waste Processing Facility (DWPF) or other feed requirements, longer pump lifetimes can be achieved with associated operational cost and

  2. ADVANCED MIXING MODELS

    SciTech Connect

    Lee, S; Dimenna, R; Tamburello, D

    2011-02-14

    The process of recovering and processing High Level Waste (HLW) the waste in storage tanks at the Savannah River Site (SRS) typically requires mixing the contents of the tank with one to four mixers (pumps) located within the tank. The typical criteria to establish a mixed condition in a tank are based on the number of pumps in operation and the time duration of operation. To ensure that a mixed condition is achieved, operating times are typically set conservatively long. This approach results in high operational costs because of the long mixing times and high maintenance and repair costs for the same reason. A significant reduction in both of these costs might be realized by reducing the required mixing time based on calculating a reliable indicator of mixing with a suitably validated computer code. The focus of the present work is to establish mixing criteria applicable to miscible fluids, with an ultimate goal of addressing waste processing in HLW tanks at SRS and quantifying the mixing time required to suspend sludge particles with the submersible jet pump. A single-phase computational fluid dynamics (CFD) approach was taken for the analysis of jet flow patterns with an emphasis on the velocity decay and the turbulent flow evolution for the farfield region from the pump. Literature results for a turbulent jet flow are reviewed, since the decay of the axial jet velocity and the evolution of the jet flow patterns are important phenomena affecting sludge suspension and mixing operations. The work described in this report suggests a basis for further development of the theory leading to the identified mixing indicators, with benchmark analyses demonstrating their consistency with widely accepted correlations. Although the indicators are somewhat generic in nature, they are applied to Savannah River Site (SRS) waste tanks to provide a better, physically based estimate of the required mixing time. Waste storage tanks at SRS contain settled sludge which varies in

  3. The mixing of fluids

    SciTech Connect

    Ottino, J.M.

    1989-01-01

    What do the eruption of Krakatau, the manufacture of puff pastry and the brightness of stars have in common Each involves some aspect of mixing. Mixing also plays a critical role in modern technology. Chemical engineers rely on mixing to ensure that substances react properly, to produce polymer blends that exhibit unique properties and to disperse drag-reducing agents in pipelines. Yet in spite of its of its ubiquity in nature and industry, mixing is only imperfectly under-stood. Indeed, investigators cannot even settle on a common terminology: mixing is often referred to as stirring by oceanographers and geophysicists, as blending by polymer engineers and as agitation by process engineers. Regardless of what the process is called, there is little doubt that it is exceedingly complex and is found in a great variety of systems. In constructing a theory of fluid mixing, for example, one has to take into account fluids that can be miscible or partially miscible and reactive or inert, and flows that are slow and orderly or very fast and turbulent. It is therefore not surprising that no single theory can explain all aspect of mixing in fluids and that straightforward computations usually fail to capture all the important details. Still, both physical experiments and computer simulations can provide insight into the mixing process. Over the past several years the authors and his colleague have taken both approaches in an effort to increase understanding of various aspect of the process-particularly of mixing involving slow flows and viscous fluids such as oils.

  4. Nrf2 in ischemic neurons promotes retinal vascular regeneration through regulation of semaphorin 6A

    PubMed Central

    Wei, Yanhong; Gong, Junsong; Xu, Zhenhua; Thimmulappa, Rajesh K.; Mitchell, Katherine L.; Welsbie, Derek S.; Biswal, Shyam; Duh, Elia J.

    2015-01-01

    Delayed revascularization of ischemic neural tissue is a major impediment to preservation of function in central nervous system (CNS) diseases including stroke and ischemic retinopathies. Therapeutic strategies allowing rapid revascularization are greatly needed to reduce ischemia-induced cellular damage and suppress harmful pathologic neovascularization. However, key mechanisms governing vascular recovery in ischemic CNS, including regulatory molecules governing the transition from tissue injury to tissue repair, are largely unknown. NF-E2-related factor 2 (Nrf2) is a major stress-response transcription factor well known for its cell-intrinsic cytoprotective function. However, its role in cell–cell crosstalk is less appreciated. Here we report that Nrf2 is highly activated in ischemic retina and promotes revascularization by modulating neurons in their paracrine regulation of endothelial cells. Global Nrf2 deficiency strongly suppresses retinal revascularization and increases pathologic neovascularization in a mouse model of ischemic retinopathy. Conditional knockout studies demonstrate a major role for neuronal Nrf2 in vascular regrowth into avascular retina. Deletion of neuronal Nrf2 results in semaphorin 6A (Sema6A) induction in hypoxic/ischemic retinal ganglion cells in a hypoxia-inducible factor-1 alpha (HIF-1α)-dependent fashion. Sema6A expression increases in avascular inner retina and colocalizes with Nrf2 in human fetal eyes. Extracellular Sema6A leads to dose-dependent suppression of the migratory phenotype of endothelial cells through activation of Notch signaling. Lentiviral-mediated delivery of Sema6A small hairpin RNA (shRNA) abrogates the defective retinal revascularization in Nrf2-deficient mice. Importantly, pharmacologic Nrf2 activation promotes reparative angiogenesis and suppresses pathologic neovascularization. Our findings reveal a unique function of Nrf2 in reprogramming ischemic tissue toward neurovascular repair via Sema6A regulation

  5. Mixing method and apparatus

    DOEpatents

    Green, Norman W.

    1982-06-15

    Method of mixing particulate materials comprising contacting a primary source and a secondary source thereof whereby resulting mixture ensues; preferably at least one of the two sources has enough motion to insure good mixing and the particulate materials may be heat treated if desired. Apparatus for such mixing comprising an inlet for a primary source, a reactor communicating therewith, a feeding means for supplying a secondary source to the reactor, and an inlet for the secondary source. Feeding means is preferably adapted to supply fluidized materials.

  6. Nearly discontinuous chaotic mixing

    SciTech Connect

    Sharp, David Howland; Lim, Hyun K; Yu, Yan; Glimm, James G

    2009-01-01

    A new scientific approach is presented for a broad class of chaotic problems involving a high degree of mixing over rapid time scales. Rayleigh-Taylor and Richtmyer-Meshkov unstable flows are typical of such problems. Microscopic mixing properties such as chemical reaction rates for turbulent mixtures can be obtained with feasible grid resolution. The essential dependence of (some) fluid mixing observables on transport phenomena is observed. This dependence includes numerical as well as physical transport and it includes laminar as well as turbulent transport. A new approach to the mathematical theory for the underlying equations is suggested.

  7. 17 CFR 240.6a-2 - Amendments to application.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Amendments to application. 240.6a-2 Section 240.6a-2 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) GENERAL RULES AND REGULATIONS, SECURITIES EXCHANGE ACT OF 1934 Rules and Regulations Under...

  8. Microbiological Transformations of Δ6a,10a-Tetrahydrocannabinol

    PubMed Central

    Fukuda, David; Archer, Robert A.; Abbott, Bernard J.

    1977-01-01

    A screening program was conducted to find microorganisms that catalyze transformation reactions with cannabinoids. Three hundred fifty-eight cultures, consisting of 97 bacteria, 175 actinomycetes, and 86 molds, were incubated in media containing 0.5 mg of Δ6a,10a-tetrahydrocannabinol (Δ6a,10a-THC) per ml. After 120 h of cultivation, ethyl acetate extracts of the cultures were examined by thin-layer chromatography (TLC) for transformation products. About 18% of the cultures modified Δ6a,10a-THC. The ability to modify the substrate did not predominate among any particular group of microorganisms. After purification, the products from three cultures were analyzed by high-resolution mass spectrometry, 100-mHz proton magnetic resonance spectrometry, ultraviolet spectrometry, and infrared spectrometry. These spectral data indicated that a Mycobacterium sp. oxidized Δ6a,10a-THC to cannabinol and a diastereomeric pair of 6a-hydroxy-Δ10,10a-THC isomers; a Streptomyces sp. and a Bacillus sp. oxidized Δ6a,10a-THC to 7-keto-Δ6a,10a-THC and 4′-hydroxy-Δ6a,10a-THC, respectively. The occurrence of these products and the presence of others that have not yet been isolated or identified indicate that microbial transformation may be a useful tool for the preparation of new cannabinoids that have desirable pharmacological properties. PMID:406841

  9. Guidelines for mixed waste minimization

    SciTech Connect

    Owens, C.

    1992-02-01

    Currently, there is no commercial mixed waste disposal available in the United States. Storage and treatment for commercial mixed waste is limited. Host States and compacts region officials are encouraging their mixed waste generators to minimize their mixed wastes because of management limitations. This document provides a guide to mixed waste minimization.

  10. Artificial upwelling and mixing

    SciTech Connect

    Not Available

    1989-01-01

    The authors present results related to artificial upwelling and coastal mariculture using deep ocean water and mixing in coastal waters. They discuss the application of research results for marine waste disposal.

  11. Mixed-Media Owls

    ERIC Educational Resources Information Center

    Schultz, Kathy

    2010-01-01

    The fun of creating collages is there are unlimited possibilities for the different kinds of materials one can use. In this article, the author describes how her eighth-grade students created an owl using mixed media.

  12. Asymmetric antiproton debuncher: No bad mixing, more good mixing

    SciTech Connect

    Visnjic, V.

    1994-07-01

    An asymmetric lattice for the Fermilab Antiproton Debuncher is designed. The lattice has zero mixing between the pickups and the kickers (bad mixing) while the mixing in the rest of the machine (good mixing) can be varied (even during the operation of the machine) in order to optimize the stochastic cooling. As an example, a lattice with zero bad mixing and twice the good mixing is presented. The betatron cooling rate in this lattice is twice its present value.

  13. Mixed surfactant systems for enhanced oil recovery

    SciTech Connect

    Llave, F.M.; Gall, B.L.; Noll, L.A.

    1990-12-01

    The results of an evaluation of mixed surfactant systems for enhanced oil recovery are described. Several surfactant combinations have been studied. These include alkyl aryl sulfonates as primary surfactants and carboxymethylated ethoxylated (CME) surfactants and ethoxylated sulfonates (ES) as secondary surfactants. The ethoxylated surfactants increase the salinity tolerance of the primary surfactants and, in theory, allow tailoring of the surfactant system to match selected reservoir conditions. The experiments conducted included interfacial tension (IFT) measurements, phase behavior measurements, adsorption and/or chromatographic separation of mixed surfactant systems, measurements of solution properties such as the critical micelle concentration (CMC) of surfactant mixtures, and crude oil displacement experiments. The effects of temperature, surfactant concentration, salinity, presence of divalent ions, hydrocarbon type, and component proportions in the mixed surfactant combinations, and injection strategies on the performance potential of the targeted surfactant/hydrocarbon systems were studied. 40 refs., 37 figs., 8 tabs.

  14. Leaf traits and tree rings suggest different water-use and carbon assimilation strategies by two co-occurring Quercus species in a Mediterranean mixed-forest stand in Tuscany, Italy.

    PubMed

    Tognetti, Roberto; Cherubini, Paolo; Marchi, Susanna; Raschi, Antonio

    2007-12-01

    We compared the water-use characteristics of co-occurring mature Quercus cerris L. and Quercus pubescens Willd. trees growing in resource-limited (mainly water) hilly habitats in Tuscany, Italy. The species differed in their distribution along soil water gradients and in their access to, and use of, water, even though the study year was wetter than average, though with a summer drought. Compared with Q. cerris, Q. pubescens had greater access to soil water (less negative predawn water potentials) and a more conservative water-use strategy based on its relatively low stomatal conductance, high instantaneous water-use efficiency, less negative midday water potential and high soil-to-leaf hydraulic conductance. Quercus cerris had less conservative water-use characteristics than Q. pubescens, exhibiting relatively high stomatal conductance, low instantaneous water-use efficiency, more negative midday water potentials and low soil-to-leaf hydraulic conductance; however, Q. cerris had higher photosynthetic rates than Q. pubescens. Photosynthesis and stomatal conductance were positively correlated in both species. Although a strong correlation between ring widths and precipitation patterns was not found, some dry periods influenced ring-width growth. Quercus pubescens has always grown faster than Q. cerris, probably because of more efficient water use, although stand dynamics (driven by exogenous disturbance factors, including coppicing, browsing and competition) cannot be excluded. Ring-width variability, as well as tree-ring growth in dry years, which should be unaffected by stand dynamics, were higher in Q. pubescens than in Q. cerris. Moreover, Q. pubescens recovered completely after the drought in the seventies, even showing higher tree-ring growth than in the recent past, whereas Q. cerris showed a minor growth decline followed by a recovery to values comparable with those observed before the 1970s drought. Beginning in the early eighties, tree-ring growth decreased

  15. The Telomeric Repeats of Human Herpesvirus 6A (HHV-6A) Are Required for Efficient Virus Integration.

    PubMed

    Wallaschek, Nina; Sanyal, Anirban; Pirzer, Fabian; Gravel, Annie; Mori, Yasuko; Flamand, Louis; Kaufer, Benedikt B

    2016-05-01

    Human herpesvirus 6A (HHV-6A) and 6B (HHV-6B) are ubiquitous betaherpesviruses that infects humans within the first years of life and establishes latency in various cell types. Both viruses can integrate their genomes into telomeres of host chromosomes in latently infected cells. The molecular mechanism of viral integration remains elusive. Intriguingly, HHV-6A, HHV-6B and several other herpesviruses harbor arrays of telomeric repeats (TMR) identical to human telomere sequences at the ends of their genomes. The HHV-6A and HHV-6B genomes harbor two TMR arrays, the perfect TMR (pTMR) and the imperfect TMR (impTMR). To determine if the TMR are involved in virus integration, we deleted both pTMR and impTMR in the HHV-6A genome. Upon reconstitution, the TMR mutant virus replicated comparable to wild type (wt) virus, indicating that the TMR are not essential for HHV-6A replication. To assess the integration properties of the recombinant viruses, we established an in vitro integration system that allows assessment of integration efficiency and genome maintenance in latently infected cells. Integration of HHV-6A was severely impaired in the absence of the TMR and the virus genome was lost rapidly, suggesting that integration is crucial for the maintenance of the virus genome. Individual deletion of the pTMR and impTMR revealed that the pTMR play the major role in HHV-6A integration, whereas the impTMR only make a minor contribution, allowing us to establish a model for HHV-6A integration. Taken together, our data shows that the HHV-6A TMR are dispensable for virus replication, but are crucial for integration and maintenance of the virus genome in latently infected cells.

  16. Mixed-Income Schools and Housing: Advancing the Neoliberal Urban Agenda

    ERIC Educational Resources Information Center

    Lipman, Pauline

    2008-01-01

    This article uses a social justice framework to problematize national and local policies in housing and education which propose to reduce poverty and improve educational performance of low-income students through mixed-income strategies. Drawing on research on Chicago, the article argues mixed-income strategies are part of the neoliberal…

  17. Mixing of Supersonic Streams

    NASA Technical Reports Server (NTRS)

    Hawk, C. W.; Landrum, D. B.; Muller, S.; Turner, M.; Parkinson, D.

    1998-01-01

    The Strutjet approach to Rocket Based Combined Cycle (RBCC) propulsion depends upon fuel-rich flows from the rocket nozzles and turbine exhaust products mixing with the ingested air for successful operation in the ramjet and scramjet modes. It is desirable to delay this mixing process in the air-augmented mode of operation present during low speed flight. A model of the Strutjet device has been built and is undergoing test to investigate the mixing of the streams as a function of distance from the Strutjet exit plane during simulated low speed flight conditions. Cold flow testing of a 1/6 scale Strutjet model is underway and nearing completion. Planar Laser Induced Fluorescence (PLIF) diagnostic methods are being employed to observe the mixing of the turbine exhaust gas with the gases from both the primary rockets and the ingested air simulating low speed, air augmented operation of the RBCC. The ratio of the pressure in the turbine exhaust duct to that in the rocket nozzle wall at the point of their intersection is the independent variable in these experiments. Tests were accomplished at values of 1.0, 1.5 and 2.0 for this parameter. Qualitative results illustrate the development of the mixing zone from the exit plane of the model to a distance of about 10 rocket nozzle exit diameters downstream. These data show the mixing to be confined in the vertical plane for all cases, The lateral expansion is more pronounced at a pressure ratio of 1.0 and suggests that mixing with the ingested flow would be likely beginning at a distance of 7 nozzle exit diameters downstream of the nozzle exit plane.

  18. Mixing of Supersonic Streams

    NASA Technical Reports Server (NTRS)

    Hawk, C. W.; Landrum, D. B.; Muller, S.; Turner, M.; Parkinson, D.

    1998-01-01

    The Strutjet approach to Rocket Based Combined Cycle (RBCC) propulsion depends upon fuel-rich flows from the rocket nozzles and turbine exhaust products mixing with the ingested air for successful operation in the ramjet and scramjet modes. It is desirable to delay this mixing process in the air-augmented mode of operation present during low speed flight. A model of the Strutjet device has been built and is undergoing test to investigate the mixing of the streams as a function of distance from the Strutjet exit plane during simulated low speed flight conditions. Cold flow testing of a 1/6 scale Strutjet model is underway and nearing completion. Planar Laser Induced Fluorescence (PLIF) diagnostic methods are being employed to observe the mixing of the turbine exhaust gas with the gases from both the primary rockets and the ingested air simulating low speed, air augmented operation of the RBCC. The ratio of the pressure in the turbine exhaust duct to that in the rocket nozzle wall at the point of their intersection is the independent variable in these experiments. Tests were accomplished at values of 1.0, 1.5 and 2.0 for this parameter. Qualitative results illustrate the development of the mixing zone from the exit plane of the model to a distance of about 19 equivalent rocket nozzle exit diameters downstream. These data show the mixing to be confined in the vertical plane for all cases, The lateral expansion is more pronounced at a pressure ratio of 1.0 and suggests that mixing with the ingested flow would be likely beginning at a distance of 7 nozzle exit diameters downstream of the nozzle exit plane.

  19. 6. A PHOTOGRAPH LOOKING WEST, TAKEN FROM THE ROADWAY OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. A PHOTOGRAPH LOOKING WEST, TAKEN FROM THE ROADWAY OF THE BRIDGE, SHOWING A DOWNSTREAM VIEW OF ROCK CREEK DITCH. - Wells County Bridge No. 74, Spanning Rock Creek Ditch at County Road 400, Bluffton, Wells County, IN

  20. Mixed waste management options

    SciTech Connect

    Owens, C.B.; Kirner, N.P.

    1991-12-31

    Disposal fees for mixed waste at proposed commercial disposal sites have been estimated to be $15,000 to $40,000 per cubit foot. If such high disposal fees are imposed, generators may be willing to apply extraordinary treatment or regulatory approaches to properly dispose of their mixed waste. This paper explores the feasibility of several waste management scenarios and attempts to answer the question: Can mixed waste be managed out of existence? Existing data on commercially generated mixed waste streams are used to identify the realm of mixed waste known to be generated. Each waste stream is evaluated from both a regulatory and technical perspective in order to convert the waste into a strictly low-level radioactive or a hazardous waste. Alternative regulatory approaches evaluated in this paper include a delisting petition, no migration petition, and a treatability variance. For each waste stream, potentially available treatment options are identified that could lead to these variances. Waste minimization methodology and storage for decay are also considered. Economic feasibility of each option is discussed broadly.

  1. HHV-6A in syncytial giant-cell hepatitis.

    PubMed

    Potenza, Leonardo; Luppi, Mario; Barozzi, Patrizia; Rossi, Giulio; Cocchi, Stefania; Codeluppi, Mauro; Pecorari, Monica; Masetti, Michele; Di Benedetto, Fabrizio; Gennari, William; Portolani, Marinella; Gerunda, Giorgio Enrico; Lazzarotto, Tiziana; Landini, Maria Paola; Schulz, Thomas F; Torelli, Giuseppe; Guaraldi, Giovanni

    2008-08-07

    Syncytial giant-cell hepatitis is a rare but severe form of hepatitis that is associated with autoimmune diseases, drug reactions, and viral infections. We used serologic, molecular, and immunohistochemical methods to search for an infectious cause in a case of syncytial giant-cell hepatitis that developed in a liver-transplant recipient who had latent infection with variant B of human herpesvirus 6 (HHV-6B) and who had received the organ from a donor with variant A latent infection (HHV-6A). At the onset of the disease, the detection of HHV-6A (but not HHV-6B) DNA in plasma, in affected liver tissue, and in single micromanipulated syncytial giant cells with the use of two different polymerase-chain-reaction (PCR) assays indicated the presence of active HHV-6A infection in the patient. Expression of the HHV-6A-specific early protein, p41/38, but not of the HHV-6B-specific late protein, p101, was demonstrated only in liver syncytial giant cells in the absence of other infectious pathogens. The same markers of HHV-6A active infection were documented in serial follow-up samples from the patient and disappeared only at the resolution of syncytial giant-cell hepatitis. Neither HHV-6B DNA nor late protein was identified in the same follow-up samples from the patient. Thus, HHV-6A may be a cause of syncytial giant-cell hepatitis.

  2. Environmental and Water Quality Operational Studies: Mixing in Rivers.

    DTIC Science & Technology

    1986-09-01

    Streams," J. Envir. Engrg. Div., ASCE, Vol 109, No. 5, pp 1049-1067. Beltaos , S . 1975. "Evaluation of Transverse Mixing Coefficients from Slug Tests...PERFORMING ORGANIZATION REPORT NUMBER( S ) 5 MONITORING ORGANIZATION REPORT NUMBER( S ) Technical Report E-86-11 6a NAME OF PERFORMING ORGANIZTIO OFFICE...IC.3 11I TITLE (include Security Classification) Mixing in Rivers * 12 PERSONAL AUTHOR( S ) * Holley, Edward R., and Jirka, Gerhard H. 13a TYPE OF

  3. Mixed waste: Proceedings

    SciTech Connect

    Moghissi, A.A.; Blauvelt, R.K.; Benda, G.A.; Rothermich, N.E.

    1993-12-31

    This volume contains the peer-reviewed and edited versions of papers submitted for presentation a the Second International Mixed Waste Symposium. Following the tradition of the First International Mixed Waste Symposium, these proceedings were prepared in advance of the meeting for distribution to participants. The symposium was organized by the Mixed Waste Committee of the American Society of Mechanical Engineers. The topics discussed at the symposium include: stabilization technologies, alternative treatment technologies, regulatory issues, vitrification technologies, characterization of wastes, thermal technologies, laboratory and analytical issues, waste storage and disposal, organic treatment technologies, waste minimization, packaging and transportation, treatment of mercury contaminated wastes and bioprocessing, and environmental restoration. Individual abstracts are catalogued separately for the data base.

  4. Natural convective mixing flows

    NASA Astrophysics Data System (ADS)

    Ramos, Eduardo; de La Cruz, Luis; del Castillo, Luis

    1998-11-01

    Natural convective mixing flows. Eduardo Ramos and Luis M. de La Cruz, National University of Mexico and Luis Del Castillo San Luis Potosi University. The possibility of mixing a fluid with a natural convective flow is analysed by solving numerically the mass, momentum and energy equations in a cubic container. Two opposite vertical walls of the container are assumed to have temperatures that oscillate as functions of time. The phase of the oscillations is chosen in such a way that alternating corrotating vortices are formed in the cavity. The mixing efficiency of this kind of flow is examined with a Lagrangian tracking technique. This work was partially financed by CONACyT-Mexico project number GE0044

  5. Remotely controllable mixing system

    NASA Technical Reports Server (NTRS)

    Belew, Robert R. (Inventor)

    1987-01-01

    A remotely controllable mixing system (210) in which a plurality of mixing assemblies (10a-10e) are arranged in an annular configuration, and wherein each assembly (10) employs a central chamber (16) and two outer, upper and lower, chambers (12, 14). Valves (18, 20) are positioned between chambers, and these valves (18, 20) for a given mixing assembly (10) are operated by upper and lower control rotors (29), which in turn are driven by upper and lower drive rotors (270, 270b). Additionally, a hoop (278) is compressed around upper control rotors (29) and a hoop (278b) is compressed around lower control rotors (29) to thus insure constant frictional engagement between all control rotors (29) and drive rotors (270, 270b). The drive rollers (270, 270b) are driven by a motor (213).

  6. Dilution jet mixing program

    NASA Technical Reports Server (NTRS)

    Srinivasan, R.; Coleman, E.; Johnson, K.

    1984-01-01

    Parametric tests were conducted to quantify the mixing of opposed rows of jets (two-sided injection) in a confined cross flow. Results show that jet penetrations for two sided injections are less than that for single-sided injections, but the jet spreading rates are faster for a given momentum ratio and orifice plate. Flow area convergence generally enhances mixing. Mixing characteristics with asymmetric and symmetric convergence are similar. For constant momentum ratio, the optimum S/H(0) with in-line injections is one half the optimum value for single sided injections. For staggered injections, the optimum S/H(0) is twice the optimum value for single-sided injection. The correlations developed predicted the temperature distributions within first order accuracy and provide a useful tool for predicting jet trajectory and temperature profiles in the dilution zone with two-sided injections.

  7. Atomization and mixing study

    NASA Technical Reports Server (NTRS)

    Ferrenberg, A.; Jaqua, V. W.

    1983-01-01

    The state of the art in atomization and mixing for triplet, pentad, and coaxial injectors is described. Injectors that are applicable for LOX/hydrocarbon propellants and main chamber and fuel rich preburner/gas generator mixture ratios are of special interest. Various applicable correlating equations and parameters as well as test data found in the literature are presented. The validity, utility, and important aspects of these data and correlations are discussed and the measurement techniques used are evaluated. Propellant mixing tests performed are described and summarized, results are reported, and tentative conclusions are included.

  8. Mixed crystal organic scintillators

    DOEpatents

    Zaitseva, Natalia P; Carman, M Leslie; Glenn, Andrew M; Hamel, Sebastien; Hatarik, Robert; Payne, Stephen A; Stoeffl, Wolfgang

    2014-09-16

    A mixed organic crystal according to one embodiment includes a single mixed crystal having two compounds with different bandgap energies, the organic crystal having a physical property of exhibiting a signal response signature for neutrons from a radioactive source, wherein the signal response signature does not include a significantly-delayed luminescence characteristic of neutrons interacting with the organic crystal relative to a luminescence characteristic of gamma rays interacting with the organic crystal. According to one embodiment, an organic crystal includes bibenzyl and stilbene or a stilbene derivative, the organic crystal having a physical property of exhibiting a signal response signature for neutrons from a radioactive source.

  9. Atomization and Mixing Study

    NASA Technical Reports Server (NTRS)

    Ferrenberg, A.; Hunt, K.; Duesberg, J.

    1985-01-01

    The primary objective was the obtainment of atomization and mixing performance data for a variety of typical liquid oxygen/hydrocarbon injector element designs. Such data are required to establish injector design criteria and to provide critical inputs to liquid rocket engine combustor performance and stability analysis, and computational codes and methods. Deficiencies and problems with the atomization test equipment were identified, and action initiated to resolve them. Test results of the gas/liquid mixing tests indicated that an assessment of test methods was required. A series of 71 liquid/liquid tests were performed.

  10. The Human Homologue of Macaque Area V6A

    PubMed Central

    Pitzalis, S.; Sereno, M.I.; Committeri, G.; Fattori, P.; Galati, G.; Tosoni, A.; Galletti, C.

    2013-01-01

    In macaque monkeys, V6A is a visuomotor area located in the anterior bank of the POs, dorsal and anterior to retinotopically-organized extrastriate area V6 (Galletti et al 1996). Unlike V6, V6A represents both contra- and ipsilateral visual fields and is broadly retinotopically organized (Galletti et al 1999b). The contralateral lower visual field is overrepresented in V6A. The central 20°–30° of the visual field are mainly represented dorsally (V6Ad) and the periphery ventrally (V6Av), at the border with V6. Both sectors of area V6A contain arm movement-related cells, active during spatially-directed reaching movements (Gamberini et al., 2011). In humans, we previously mapped the retinotopic organization of area V6 (Pitzalis et al., 2006). Here, using phase-encoded fMRI, cortical surface-based analysis and wide-field retinotopic mapping, we define a new cortical region that borders V6 anteriorly and shows a clear over-representation of the contralateral lower visual field and of the periphery. As with macaque V6A, the eccentricity increases moving ventrally within the area. The new region contains a non-mirror-image representation of the visual field. Functional mapping reveals that, as in macaque V6A, the new region, but not the nearby area V6, responds during finger pointing and reaching movements. Based on similarity in position, retinotopic properties, functional organization and relationship with the neighbouring extrastriate visual areas, we propose that the new cortical region is the human homologue of macaque area V6A. PMID:23770406

  11. Appropriate strategies.

    PubMed

    Halty, M

    1979-01-01

    Technology strategies are concerned with the production, distribution, and consumption of technology. Observation of less developed countries (LDCs) and international organizations shows that little attention is given to the development of a technology strategy. LDCs need to formulate a strategy of self-reliant technological development for the next decade. They should no longer be content to stand in a technologically dependent relationship to the developed countries. Such strategies must balance the ratio between investment in indigenous technologies and expenditure for foreign technology. The strategies change according to the level of industrialization achieved. The following considerations come into development of technology strategies: 1) determination of an appropriate balance among the accumulation, consumption, and distribution of technology; 2) the amount and level of government support; and 3) the balance between depth and breadth of technology to be encouraged.

  12. Sylgard® Mixing Study

    SciTech Connect

    Bello, Mollie; Welch, Cynthia F.; Goodwin, Lynne Alese; Keller, Jennie

    2014-08-22

    Sylgard® 184 and Sylgard® 186 silicone elastomers form Dow Corning® are used as potting agents across the Nuclear Weapons Complex. A standardized mixing procedure is required for filled versions of these products. The present study is a follow-up to a mixing study performed by MST-7 which established the best mixing procedure to use when adding filler to either 184 or 186 base resins. The most effective and consistent method of mixing resin and curing agent for three modified silicone elastomer recipes is outlined in this report. For each recipe, sample size, mixing type, and mixing time was varied over 10 separate runs. The results show that the THINKY™ Mixer gives reliable mixing over varying batch sizes and mixing times. Hand Mixing can give improved mixing, as indicated by reduced initial viscosity; however, this method is not consistent.

  13. Mixing and Transport.

    ERIC Educational Resources Information Center

    Ditmars, John D.

    1978-01-01

    Presents a literature review of longitudinal dispersion, mixing and transport in streams, rivers, lakes, reservoirs, estuaries, and oceans. This review covers also: (1) fluid-solid mixtures and (2) oil spill behavior. A list of 189 references published in 1976 and 1977 is presented. (HM)

  14. Mixed-Initiative Clustering

    ERIC Educational Resources Information Center

    Huang, Yifen

    2010-01-01

    Mixed-initiative clustering is a task where a user and a machine work collaboratively to analyze a large set of documents. We hypothesize that a user and a machine can both learn better clustering models through enriched communication and interactive learning from each other. The first contribution or this thesis is providing a framework of…

  15. Stabilizer for mixed fuels

    SciTech Connect

    Yamamura, M.; Igarashi, T.; Ukigai, T.

    1984-03-13

    A stabilizer for mixed fuels containing a reaction product obtained by reacting (1) a polyol having at least 3 hydroxyl groups in the molecule and a molecular weight of 400-10,000 with (2) an epihalohydrin, as the principal component.

  16. True Anonymity Without Mixes

    NASA Astrophysics Data System (ADS)

    Molina-Jimenez, C.; Marshall, L.

    2002-04-01

    Anonymizers based on mix computers interposed between the sender and the receiver of an e-mail message have been used in the Internet for several years by senders of e-mail messages who do not wish to disclose their identity. Unfortunately, the degree of anonymity provided by this paradigm is limited and fragile. First, the messages sent are not truly anonymous but pseudo-anonymous since one of the mixes, at least, always knows the sender's identity. Secondly, the strength of the system to protect the sender's identity depends on the ability and the willingness of the mixes to keep the secret. If the mixes fail, the sender/'s anonymity is reduced to pieces. In this paper, we propose a novel approach for sending truly anonymous messages over the Internet where the anonymous message is sent from a PDA which uses dynamically assigned temporary, non-personal, random IP and MAC addresses. Anonymous E-cash is used to pay for the service.

  17. Radial Mixing in Turbomachines

    DTIC Science & Technology

    1991-03-31

    Belgium March 31, 1991 Final Scientific Report June 1, 1989 - July 31, 1990 VUB -STR -17 Approved for public release; distribution unlimited. - Prepared ...secondary flows and turbulence as sources of mixing was investigated by conducting experiments using hot-wire anemometry and ehtylene tracer gas

  18. 6. A VIEW TOWARD THE EAST SIDE OF BUILDING NO. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. A VIEW TOWARD THE EAST SIDE OF BUILDING NO. 1, SHOWING THE OFFICE SECTION AT THE SOUTHEAST CORNER. BUILDING NO. 18 (ENGINEERING BUILDING) IS VISIBLE IN THE CENTER DISTANCE, AND BUILDING NO. 12 (OFFICE/SUBSTATION) AT THE RIGHT. - United Engineering Company Shipyard, 2900 Main Street, Alameda, Alameda County, CA

  19. REORGANIZED SCIENCE CURRICULUM, 6A, SIXTH GRADE SUPPLEMENT.

    ERIC Educational Resources Information Center

    Minneapolis Special School District 1, Minn.

    THE NINTH IN A SERIES OF 17 VOLUMES, THIS VOLUME PROVIDES THE SIXTH GRADE TEACHER WITH A GUIDE TO THE REORGANIZED SCIENCE CURRICULUM OF THE MINNEAPOLIS PUBLIC SCHOOLS. THE MATERIALS ARE INTENDED TO BE AUGMENTED AND REVISED AS THE NEED ARISES. THE SIXTH GRADE SUPPLEMENT IS IN THREE VOLUMES. VOLUME 6A HAS A DETAILED OUTLINE OF THE SUBJECT MATTER FOR…

  20. 7 CFR 245.6a - Verification requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AGRICULTURE CHILD NUTRITION PROGRAMS DETERMINING ELIGIBILITY FOR FREE AND REDUCED PRICE MEALS AND FREE MILK IN SCHOOLS § 245.6a Verification requirements. (a) Definitions—(1) Eligible programs. For the purposes of... price meal benefits or free milk to the agency administering an eligible program, the Medicaid...

  1. Quantum Games: Mixed Strategy Nash's Equilibrium Represents Minimum Entropy

    NASA Astrophysics Data System (ADS)

    Jiménez, Edward

    2003-12-01

    This paper introduces Hermite's polynomials, in the description of quantum games. Hermite's polynomials are associated with gaussian probability density. The gaussian probability density represents minimum dispersion. I introduce the concept of minimum entropy as a paradigm of both Nash's equilibrium (maximum utility MU) and Hayek equilibrium (minimum entropy ME). The ME concept is related to Quantum Games. Some questions arise after carrying out this exercise: i) What does Heisenberg's uncertainty principle represent in Game Theory and Time Series?, and ii) What do the postulates of Quantum Mechanics indicate in Game Theory and Economics?.

  2. Strategies for analyzing mixed pixels in remotely sensed imagery

    NASA Technical Reports Server (NTRS)

    Smith, M.; Adams, J.

    1985-01-01

    Two uncalibrated synthetic aperture radar (SAR) scenes from Death Valley, California, and two uncalibrated scenes from Owens Valley, California, were used to test a technique to identify and separate the primary factors associated with multipolarized radar image sets. Unique to the technique is the concept that varied types of radar polarization signatures are a result of the interaction of a few physical factors (e.g., roughness, volume scattering, and dielectric constant). Thus, the varied signatures observed in an image reflect the interaction between these factors. The objectives are to first separate the interaction of factors directly influencing the measurement and to attempt to identify these factors. Interpretation of the SAR image sets proceeds by testing models that hypothesize the cause and effect relations between those factors directly affecting the radar measurement and those features of interest to the interpreter. The results of our analysis indicated two consistent endmember types over all four image scenes. These types are defined by a high flat polarized signature near a level of 255 DN and a low level flat signature near 0 DN for all polarizations. Four other endmember types were also isolated. The spatial distribution of these endmember types indicates possible correspondence to surface volume scattering and changes in surface dielectric. However, the shapes of these endmember types were different from scene to scene.

  3. Mixing by individual swimmers

    NASA Astrophysics Data System (ADS)

    Pushkin, Dmitri; Shum, Henry; Yeomans, Julia

    2012-11-01

    Despite their evolutionary and technological importance, different biomixing mechanisms, their effectiveness and universality remain poorly understood. In this talk we focus on the Lagrangian transport of the surrounding fluid by swimmers. Low Re passive tracers advected by swimmers move in loops that are, in general, almost closed. We analyze the reasons for this behavior and, as non-closedness of the loops is a natural requirement for an efficient mixing, propose a classification of possible mechanisms for biogenic mixing. Next, we discuss the universal (common to all swimmers) and the swimmer-dependent features of the resulting tracer displacements and analyze the Darwin drift, the total fluid volume displaced by a swimmer passing from and to infinity. We show that the Darwin drift is finite for force-free swimmers and can be decomposed into a universal and a swimmer-dependent part. We illustrate our consideration with examples for model swimmers and biological data.

  4. Experiments in mixed reality

    NASA Astrophysics Data System (ADS)

    Krum, David M.; Sadek, Ramy; Kohli, Luv; Olson, Logan; Bolas, Mark

    2010-01-01

    As part of the Institute for Creative Technologies and the School of Cinematic Arts at the University of Southern California, the Mixed Reality lab develops technologies and techniques for presenting realistic immersive training experiences. Such experiences typically place users within a complex ecology of social actors, physical objects, and collections of intents, motivations, relationships, and other psychological constructs. Currently, it remains infeasible to completely synthesize the interactivity and sensory signatures of such ecologies. For this reason, the lab advocates mixed reality methods for training and conducts experiments exploring such methods. Currently, the lab focuses on understanding and exploiting the elasticity of human perception with respect to representational differences between real and virtual environments. This paper presents an overview of three projects: techniques for redirected walking, displays for the representation of virtual humans, and audio processing to increase stress.

  5. DOE acceptance of commercial mixed waste -- Studies are under way

    SciTech Connect

    Plummer, T.L.; Owens, C.M.

    1993-03-01

    The topic of the Department of Energy acceptance of commercial mixed waste at DOE facilities has been proposed by host States and compact regions that are developing low-level radioactive waste disposal facilities. States support the idea of DOE accepting commercial mixed waste because (a) very little commercial mixed waste is generated compared to generation by DOE facilities (Department of Energy--26,300 cubic meters annually vs. commercial--3400 cubic meters annually); (b) estimated costs for commercial disposal are estimated to be $15,000 to $40,000 per cubic foot; (c) once treatment capability becomes available, 70% of the current levels of commercial mixed waste will be eliminated, (d) some State laws prohibit the development of mixed waste disposal facilities in their States; (e) DOE is developing a nationwide strategy that will include treatment and disposal capacity for its own mixed waste and the incremental burden on the DOE facilities would be minuscule, and (6) no States are developing mixed waste disposal facilities. DOE senior management has repeatedly expressed willingness to consider investigating the feasibility of DOE accepting commercial mixed waste. In January 1991, Leo Duffy of the Department of energy met with members of the Low-Level Radioactive Waste Forum, which led to an agreement to explore such an arrangement. He stated that this seems like a cost-effective way to solve commercial mixed waste management problems.

  6. Magnetically driven surface mixing

    NASA Astrophysics Data System (ADS)

    Belkin, M.; Snezhko, A.; Aranson, I. S.; Kwok, W.-K.

    2009-07-01

    Magnetic microparticles suspended on the surface of liquid and energized by vertical alternating magnetic field exhibit complex collective behavior. Various immobile and self-propelled self-assembled structures have been observed. Here, we report on experimental studies of mixing and surface diffusion processes in this system. We show that the pattern-induced surface flows have properties of quasi-two-dimensional turbulence. Correspondingly, the surface advection of tracer particle exhibits properties of Brownian diffusion.

  7. Monolithic gyroidal mesoporous mixed titanium-niobium nitrides.

    PubMed

    Robbins, Spencer W; Sai, Hiroaki; DiSalvo, Francis J; Gruner, Sol M; Wiesner, Ulrich

    2014-08-26

    Mesoporous transition metal nitrides are interesting materials for energy conversion and storage applications due to their conductivity and durability. We present ordered mixed titanium-niobium (8:2, 1:1) nitrides with gyroidal network structures synthesized from triblock terpolymer structure-directed mixed oxides. The materials retain both macroscopic integrity and mesoscale ordering despite heat treatment up to 600 °C, without a rigid carbon framework as a support. Furthermore, the gyroidal lattice parameters were varied by changing polymer molar mass. This synthesis strategy may prove useful in generating a variety of monolithic ordered mesoporous mixed oxides and nitrides for electrode and catalyst materials.

  8. Mixed-Methods Research in the Discipline of Nursing.

    PubMed

    Beck, Cheryl Tatano; Harrison, Lisa

    2016-01-01

    In this review article, we examined the prevalence and characteristics of 294 mixed-methods studies in the discipline of nursing. Creswell and Plano Clark's typology was most frequently used along with concurrent timing. Bivariate statistics was most often the highest level of statistics reported in the results. As for qualitative data analysis, content analysis was most frequently used. The majority of nurse researchers did not specifically address the purpose, paradigm, typology, priority, timing, interaction, or integration of their mixed-methods studies. Strategies are suggested for improving the design, conduct, and reporting of mixed-methods studies in the discipline of nursing.

  9. Flows, Turbulence, and Mixing

    NASA Astrophysics Data System (ADS)

    Lazarian, Alex

    2003-07-01

    HST and FUSE spectra of distant UV-bright sources reveal interstellar absorption lines of high stages of ionization {O VI, C IV, N V, Si IV} arising in many different astrophysical environments such as superbubbles, interstellar chimneys, high-velocity clouds, galaxy halos and cosmic filaments. Turbulence, always present in the magnetized ISM, must mix the hot { 10^6 K} gas with cooler gas within "turbulent mixing layers". Present theory, based on 1D steady-state flows, suggest the line ratios in these layers differ significantly from photoionized gas, radiative shocks, cooling zones, or conduction fronts. These models are use to infer mass and energy fluxes important to understanding the ISM. We propose to develop a suite of 3D time-dependent models that properly calculate turbulent mixing. We will produce synthetic UV absorption lines and optical emission lines directly relevant to HST observations that use GHRS, STIS, and eventually, COS. These models will allow us to explore the sensitivity of the spectral diagnostics to magnetic field strength, turbulence intensity, and relative velocity of the hot and cold gas. We will publish the resulting grid of spectral diagnostics and make them available through the Web.

  10. Stochastic neutrino mixing mechanism

    NASA Astrophysics Data System (ADS)

    Guzzo, M. M.; de Holanda, P. C.; Peres, O. L. G.; Zavanin, E. M.

    2013-05-01

    We propose a mechanism which provides an explanation of the Gallium and antineutrino reactor anomalies. Differently from original Pontecorvo’s hypothesis, this mechanism is based on the phenomenological assumption in which the admixture of neutrino mass eigenstates in the moments of neutrino creation and detection can assume different configurations around the admixture parametrized by the usual values of the mixing angles θ12, θ23, and θ13. For simplicity, we assume a Gaussian distribution for the mixing angles in such a way that the average value of this distribution is given by the usual values of the mixing angles, and the width of the Gaussian is denoted by α. We show that the proposed mechanism provides a possible explanation for very short-baseline neutrino disappearance, necessary to accommodate Gallium and antineutrino reactor anomalies, which is not allowed in usual neutrino oscillations based on Pontecorvo’s original hypotheses. We also can describe high-energy oscillation experiments, like LSND, Fermi, and NuTeV, assuming a weakly energy dependent width parameter, α(E), that nicely fits all experimental results.

  11. Methods and Strategies: Talk Strategies

    ERIC Educational Resources Information Center

    Shea, Lauren M.; Shanahan, Therese B.

    2011-01-01

    This article discusses how to promote oral language development through science. The authors describe how they incorporate academic "talk strategies" into science lessons in a nonintrusive and meaningful manner. These talk strategies are adapted from the "Avenues" (2007) curriculum for English learners (ELs), which gives examples of cooperative…

  12. Utilization of a Marketing Strategy at Naval Regional Medical Center Great Lakes, Great Lakes, Illinois

    DTIC Science & Technology

    1983-06-01

    22 Analysis of the Mare.....................22 Development of the Marketing Mix .. .......... 29 A Marketing Mix --Recommendations...problem. Marketing strategy, marketing mix and ultimately the marketing orientation will allow hospitals to persevere and possibly thrive in a somewhat...market are currently being met at Naval Regional Medical Center Great Lakes. The fourth objective is to demonstrate an appropriate marketing mix for

  13. Mixing kaons with mixed action chiral perturbation theory

    NASA Astrophysics Data System (ADS)

    Aubin, Christopher

    2006-12-01

    We calculate the neutral kaon mixing parameter, BK , to next-to-leading order in mixed action (domain-wall valence with staggered sea quarks) chiral perturbation theory. We find the expres- sion for BK in this mixed-action case only differs from the continuum partially quenched expres- sion by an additional analytic term. Additionally, in preparation for a lattice calculation of BK with a mixed action, we discuss quantitatively the effects of the taste violations as well as finite volume effects.

  14. Mixed Waste Focus Area -- Waste form initiative

    SciTech Connect

    Nakaoka, R.; Waters, R.; Pohl, P.; Roach, J.

    1998-07-01

    The mission of the US Department of Energy`s (DOE) Mixed Waste Focus Area (MWFA) is to provide acceptable technologies that enable implementation of mixed waste treatment systems which are developed in partnership with end-users, stakeholders, tribal governments, and regulators. To accomplish this mission, a technical baseline was established in 1996 and revised in 1997. The technical baseline forms the basis for determining which technology development activities will be supported by the MWFA. The primary attribute of the technical baseline is a set of prioritized technical deficiencies or roadblocks related to implementation of mixed waste treatment systems. The Waste Form Initiative (WFI) was established to address an identified technical deficiency related to waste form performance. The primary goal of the WFI was to ensure that the mixed low-level waste (MLLW) treatment technologies being developed, currently used, or planned for use by DOE would produce final waste forms that meet the waste acceptance criteria (WAC) of the existing and/or planned MLLW disposal facilities. The WFI was limited to an evaluation of the disposal requirements for the radioactive component of MLLW. Disposal requirements for the hazardous component are dictated by the Resource Conservation and Recovery Act (RCRA), and were not addressed. This paper summarizes the technical basis, strategy, and results of the activities performed as part of the WFI.

  15. MixSIAR: advanced stable isotope mixing models in R

    EPA Science Inventory

    Background/Question/Methods The development of stable isotope mixing models has coincided with modeling products (e.g. IsoSource, MixSIR, SIAR), where methodological advances are published in parity with software packages. However, while mixing model theory has recently been ex...

  16. Investigating B Cell Development, Natural and Primary Antibody Responses in Ly-6A/Sca-1 Deficient Mice

    PubMed Central

    Yim, Michelle; Spencer, Stacey

    2016-01-01

    Ly-6A/Stem cell antigen-1 (Ly-6A/Sca-1) is a glycosylphosphatidylinositol-anchored protein expressed on many cell types including hematopoietic stem cells (HSCs) and early lymphoid-specific progenitors. Ly-6A/Sca-1 is expressed on CD4+ T cells and plays a role in regulating cellular responses to foreign antigens. The role of Ly-6A/Sca-1 in primary antibody responses has not been defined. To investigate whether Ly-6A/Sca-1 functions in humoral immunity, we first injected Ly-6A/Sca-1-deficient and wild-type control mice with chicken ovalbumin (c-Ova) protein mixed with an adjuvant. We then assessed the ability of the mice to generate a primary antibody response against cOva. We further examined the development of B cells and circulating antibody isotypes in non-immunized Ly-6A/Sca-1deficient mice to determine if Ly6A/Sca-1 functions in development irrespective of antigen-specific immune activation. Ly-6A/Sca-1/Sca-1-deficient mice did not show any significant changes in the number of B lymphocytes in the bone marrow and peripheral lymphoid tissues. Interestingly, Ly-6A/Sca-1/Sca-1-/- mice have significantly elevated serum levels of IgA with λ light chains compared to wild type controls. B cell clusters with high reactivity to anti-IgA λ monoclonal antibody were detected in the lamina propria of the gut, though this was not observed in the bone marrow and peripheral lymphoid tissues. Despite these differences, the Ly-6A/Sca-1deficient mice generated a similar primary antibody response when compared to the wild-type mice. In summary, we conclude that the primary antibody response to cOva antigen is similar in Ly-6A/Sca-1deficient and sufficient mice. In addition, we report significantly higher expression of the immunoglobulin λ light chain by B cells in lamina propria of Ly-6A/Sca-1deficient mice when compared to the wild-type control. PMID:27322740

  17. Cetacean Strategies.

    ERIC Educational Resources Information Center

    Gilliland, Denise DelGrosso

    1991-01-01

    Suggested are activities about whales for children in schools not near the ocean. Activities designed to pique students' interest in whales and to investigate the size, breathing, buoyancy, and feeding strategies of whales are discussed. (CW)

  18. Mixing, segregation, and flow of granular materials

    NASA Astrophysics Data System (ADS)

    McCarthy, Joseph J.

    1998-11-01

    This dissertation addresses mixing, segregation, and flow of granular materials with the ultimate goal of providing fundamental understanding and tools for the rational design and optimization of mixing devices. In particular, the paradigm cases of a slowly rotated tumbler mixer and flow down an inclined plane are examined. Computational work, as well as supporting experiments, are used to probe both two and three dimensional systems. In the avalanching regime, the mixing and flow can be viewed either on a global-scale or a local-scale. On the global-scale, material is transported via avalanches whose gross motion can be well described by geometrical considerations. On the local-scale, the dynamics of the particle motion becomes important; particles follow complicated trajectories that are highly sensitive to differences in size/density/morphology. By decomposing the problem in this way, it is possible to study the implications of the geometry and dynamics separately and to add complexities in a controlled fashion. This methodology allows even seemingly difficult problems (i.e., mixing in non-convex geometries, and mixing of dissimilar particles) to be probed in a simple yet methodical way. In addition this technique provides predictions of optimal mixing conditions in an avalanching tumbler, a criterion for evaluating the effect of mixer shape, and mixing enhancement strategies for both two and three dimensional mixers. In the continuous regime, the flow can be divided into two regions: a rapid flow region of the cascading layer at the free surface, and a fixed bed region undergoing solid body rotation. A continuum-based description, in which averages are taken across the layer, generates quantitative predictions about the flow in the cascading layer and agrees well with experiment. Incorporating mixing through a diffusive flux (as well as constitutive expression for segregation) within the cascading layer allows for the determination of optimal mixing conditions

  19. Optimal GENCO bidding strategy

    NASA Astrophysics Data System (ADS)

    Gao, Feng

    Electricity industries worldwide are undergoing a period of profound upheaval. The conventional vertically integrated mechanism is being replaced by a competitive market environment. Generation companies have incentives to apply novel technologies to lower production costs, for example: Combined Cycle units. Economic dispatch with Combined Cycle units becomes a non-convex optimization problem, which is difficult if not impossible to solve by conventional methods. Several techniques are proposed here: Mixed Integer Linear Programming, a hybrid method, as well as Evolutionary Algorithms. Evolutionary Algorithms share a common mechanism, stochastic searching per generation. The stochastic property makes evolutionary algorithms robust and adaptive enough to solve a non-convex optimization problem. This research implements GA, EP, and PS algorithms for economic dispatch with Combined Cycle units, and makes a comparison with classical Mixed Integer Linear Programming. The electricity market equilibrium model not only helps Independent System Operator/Regulator analyze market performance and market power, but also provides Market Participants the ability to build optimal bidding strategies based on Microeconomics analysis. Supply Function Equilibrium (SFE) is attractive compared to traditional models. This research identifies a proper SFE model, which can be applied to a multiple period situation. The equilibrium condition using discrete time optimal control is then developed for fuel resource constraints. Finally, the research discusses the issues of multiple equilibria and mixed strategies, which are caused by the transmission network. Additionally, an advantage of the proposed model for merchant transmission planning is discussed. A market simulator is a valuable training and evaluation tool to assist sellers, buyers, and regulators to understand market performance and make better decisions. A traditional optimization model may not be enough to consider the distributed

  20. Error Estimates for Mixed Methods.

    DTIC Science & Technology

    1979-03-01

    This paper presents abstract error estimates for mixed methods for the approximate solution of elliptic boundary value problems. These estimates are...then applied to obtain quasi-optimal error estimates in the usual Sobolev norms for four examples: three mixed methods for the biharmonic problem and a mixed method for 2nd order elliptic problems. (Author)

  1. Magnetically coupled system for mixing

    SciTech Connect

    Miller, III, Harlan; Meichel, George; Legere, Edward; Malkiel, Edwin; Woods, Robert Paul; Ashley, Oliver; Katz, Joseph; Ward, Jason; Petersen, Paul

    2014-04-01

    The invention provides a mixing system comprising a magnetically coupled drive system and a foil for cultivating algae, or cyanobacteria, in an open or enclosed vessel. The invention provides effective mixing, low energy usage, low capital expenditure, and ease of drive system component maintenance while maintaining the integrity of a sealed mixing vessel.

  2. Magnetically coupled system for mixing

    DOEpatents

    Miller, III, Harlan; Meichel, George; Legere, Edward; Malkiel, Edwin; Woods, Robert Paul; Ashley, Oliver; Katz, Joseph; Ward, Jason; Petersen, Paul

    2015-09-22

    The invention provides a mixing system comprising a magnetically coupled drive system and a foil for cultivating algae, or cyanobacteria, in an open or enclosed vessel. The invention provides effective mixing, low energy usage, low capital expenditure, and ease of drive system component maintenance while maintaining the integrity of a sealed mixing vessel.

  3. B Lifetimes and Mixing

    SciTech Connect

    Evans, Harold G.; /Indiana U.

    2009-05-01

    The Tevatron experiments, CDF and D0, have produced a wealth of new B-physics results since the start of Run II in 2001. We've observed new B-hadrons, seen new effects, and increased many-fold the precision with which we know the properties of b-quark systems. In these proceedings, we will discuss two of the most fruitful areas in the Tevatron B-physics program: lifetimes and mixing. We'll examine the experimental issues driving these analyses, present a summary of the latest results, and discuss prospects for the future.

  4. Twice-Exceptional Learners' Perspectives on Effective Learning Strategies

    ERIC Educational Resources Information Center

    Willard-Holt, Colleen; Weber, Jessica; Morrison, Kristen L.; Horgan, Julia

    2013-01-01

    This mixed-methods study investigates the perspectives of twice-exceptional students on learning strategies that have been recommended for them in the literature. Have the strategies recommended in the literature been implemented? Do students perceive the strategies to be beneficial in helping them learn? Participants represented a broad range of…

  5. Mixed Emotions and Coping: The Benefits of Secondary Emotions

    PubMed Central

    Braniecka, Anna; Trzebińska, Ewa; Dowgiert, Aneta; Wytykowska, Agata

    2014-01-01

    The existing empirical literature suggests that during difficult situations, the concurrent experience of positive and negative affects may be ideal for ensuring successful adaptation and well-being. However, different patterns of mixed emotions may have different adaptive consequences. The present research tested the proposition that experiencing a pattern of secondary mixed emotion (i.e., secondary emotion that embrace both positive and negative affects) more greatly promotes adaptive coping than experiencing two other patterns of mixed emotional experiences: simultaneous (i.e., two emotions of opposing affects taking place at the same time) and sequential (i.e., two emotions of opposing affects switching back and forth). Support for this hypothesis was obtained from two experiments (Studies 1 and 2) and a longitudinal survey (Study 3). The results revealed that secondary mixed emotions predominate over sequential and simultaneous mixed emotional experiences in promoting adaptive coping through fostering the motivational and informative functions of emotions; this is done by providing solution-oriented actions rather than avoidance, faster decisions regarding coping strategies (Study 1), easier access to self-knowledge, and better narrative organization (Study 2). Furthermore, individuals characterized as being prone to feeling secondary mixed emotions were more resilient to stress caused by transitions than those who were characterized as being prone to feeling opposing emotions separately (Study 3). Taken together, the preliminary results indicate that the pattern of secondary mixed emotion provides individuals with a higher capacity to handle adversity than the other two patterns of mixed emotional experience. PMID:25084461

  6. Mixed emotions and coping: the benefits of secondary emotions.

    PubMed

    Braniecka, Anna; Trzebińska, Ewa; Dowgiert, Aneta; Wytykowska, Agata

    2014-01-01

    The existing empirical literature suggests that during difficult situations, the concurrent experience of positive and negative affects may be ideal for ensuring successful adaptation and well-being. However, different patterns of mixed emotions may have different adaptive consequences. The present research tested the proposition that experiencing a pattern of secondary mixed emotion (i.e., secondary emotion that embrace both positive and negative affects) more greatly promotes adaptive coping than experiencing two other patterns of mixed emotional experiences: simultaneous (i.e., two emotions of opposing affects taking place at the same time) and sequential (i.e., two emotions of opposing affects switching back and forth). Support for this hypothesis was obtained from two experiments (Studies 1 and 2) and a longitudinal survey (Study 3). The results revealed that secondary mixed emotions predominate over sequential and simultaneous mixed emotional experiences in promoting adaptive coping through fostering the motivational and informative functions of emotions; this is done by providing solution-oriented actions rather than avoidance, faster decisions regarding coping strategies (Study 1), easier access to self-knowledge, and better narrative organization (Study 2). Furthermore, individuals characterized as being prone to feeling secondary mixed emotions were more resilient to stress caused by transitions than those who were characterized as being prone to feeling opposing emotions separately (Study 3). Taken together, the preliminary results indicate that the pattern of secondary mixed emotion provides individuals with a higher capacity to handle adversity than the other two patterns of mixed emotional experience.

  7. Collisional atomic mixing

    NASA Astrophysics Data System (ADS)

    Biersack, Jochen P.

    The collisional mixing of thin metal markers in silicon is investigated with the computer program TRIM-DYNAMIC (T-DYN). This code assumes that at high dose irradiation, the substrate Si or Ge, will get fully amorphized, and the recoil atom can stop in any position after slowing down below a certain final energy Ef (taken here as 3 eV). In order to avoid chemical effects, the system Au marker in a silicon matrix was chosen for the TRIM simulation. The results are in good agreement with the experimental findings, as compiled in the review article by Paine and Averback. Similar collisional mixing effects occur in the process of SIMS or Auger electron depth profiling, and cannot be avoided. An example is given here for a thin layer of arsenic vapor deposited on Si and covered by amorphous silicon. The analysing ion beam in this case was 14.5 keV Cs+ incident at 37° towards the surface normal. In comparison with the SIMS measurements by modern depth profiling equipment, again good agreement was found between the T-DYN results and the experiment.

  8. Transition mixing study

    NASA Technical Reports Server (NTRS)

    Reynolds, R.; White, C.

    1986-01-01

    A computer model capable of analyzing the flow field in the transition liner of small gas turbine engines is developed. A FORTRAN code has been assembled from existing codes and physical submodels and used to predict the flow in several test geometries which contain characteristics similar to transition liners, and for which experimental data was available. Comparisons between the predictions and measurements indicate that the code produces qualitative results but that the turbulence models, both K-E and algebraic Reynolds Stress, underestimate the cross-stream diffusion. The code has also been used to perform a numerical experiment to examine the effect of a variety of parameters on the mixing process in transition liners. Comparisons illustrate that geometries with significant curvature show a drift of the jet trajectory toward the convex wall and weaker wake region vortices and decreased penetration for jets located on the convex wall of the liner, when compared to jets located on concave walls. Also shown were the approximate equivalency of angled slots and round holes and a technique by which jet mixing correlations developed for rectangular channels can be used for can geometries.

  9. Wave mixing spectroscopy

    SciTech Connect

    Smith, R.W.

    1980-08-01

    Several new aspects of nonlinear or wave mixing spectroscopy were investigated utilizing the polarization properties of the nonlinear output field and the dependence of this field upon the occurrence of multiple resonances in the nonlinear susceptibility. First, it is shown theoretically that polarization-sensitive detection may be used to either eliminate or controllably reduce the nonresonant background in coherent anti-Stokes Raman spectroscopy, allowing weaker Raman resonances to be studied. The features of multi-resonant four-wave mixing are examined in the case of an inhomogeneously broadened medium. It is found that the linewidth of the nonlinear output narrows considerably (approaching the homogeneous width) when the quantum mechanical expressions for the doubly- and triply-resonant susceptibilities are averaged over a Doppler or strain broadened profile. Experimental studies of nonlinear processes in Pr/sup +3/:LaF/sub 3/ verify this linewidth narrowing, but indicate that this strain broadened system cannot be treated with a single broadening parameter as in the case of Doppler broadening in a gas. Several susceptibilities are measured from which are deduced dipole matrix elements and Raman polarizabilities related to the /sup 3/H/sub 4/, /sup 3/H/sub 6/, and /sup 3/P/sub 0/ levels of the praseodymium ions.

  10. Control of jet flow mixing and stabilization

    NASA Astrophysics Data System (ADS)

    Yuan, Chih-Chung

    This dissertation examines the effect of feedback controllers on mixing and stabilization of unstable two-dimensional jet flows. The mixing enhancement control law uses a pair of actuators at the jet nozzle exit acting on the shear layers near the corners by blowing and subtracting fluid in an anti-symmetric fashion with a zero net mass flux. The sensor measures the pressure difference across the nozzle diameter and is either located at downstream or at the nozzle exit with time delay. If the length/time scale is long enough and the feedback gain is sufficiently large, this control strategy will provide a constant vortex generation pattern that successfully improves mixing. The evolution of a passive scalar and mixing of particles with mass in jet flows are visualized and quantified. Probability Density Functions based on the particle/scalar distribution are constructed as measures of mixing. The stabilization control law employs filaments with distributed sensors and actuators in the jet flow. The sensors measure the local pressure difference across nozzle diameter and the actuators act as a reaction body force in the normal direction. The instability is damped with sufficiently large feedback gain. The Reynolds numbers of jet flows studied are 100 and 150 that are in the transient range. The results are obtained by means of Direct Numerical Simulation. The Navier-Stokes equations are spatially discretized by second order finite-difference method and advanced in time using a fractional step technique with a hybrid Runge-Kutta/Crank-Nicolson time discretization. This hybrid technique is developed to gain a larger time step while numerical stability is maintained. Stretched and staggered grids are used in both stream-wise and normal directions. The simulation results are validated by comparison with previous works and through self-similar analysis.

  11. Metacognitive Strategies.

    PubMed

    Schiff, Rachel; Nuri Ben-Shushan, Yohi; Ben-Artzi, Elisheva

    This study assessed the effect of metacognitive instruction on the spelling and word reading of Hebrew-speaking children with specific language impairment (SLI). Participants were 67 kindergarteners with SLI in a supported learning context. Children were classified into three spelling instruction groups: (a) metalinguistic instruction (ML), (b) ML that integrates metacognitive strategies (MCML), and (c) a control group. Letter naming, letter sounding, word spelling, and word recognition were assessed at pretest and posttest. Findings from spelling and reading tests as well as interviews indicated that both the ML and MCML groups made statistically significant gains in all measures, whereas the control group did not. However, children with SLI who received training in metacognitive strategies significantly outperformed those who received ML alone in spelling and reading skills. This study provides evidence that children with SLI benefit from applying of metacognitive strategies to spelling practices when acquiring early spelling and reading skills.

  12. Samoan Passage Abyssal Mixing Experiment

    NASA Astrophysics Data System (ADS)

    Mickett, J. B.; Voet, G.; Alford, M. H.; Girton, J. B.; Carter, G. S.

    2012-12-01

    The majority of the bottom water entering the North Pacific, about 6 Sv of mostly Antarctic origin, flows northward through the Samoan Passage (SP), where previous hydrographic studies have inferred extremely strong watermass modification as it transits the complicated, narrow passage. Global-scale numerical models at best poorly resolve this critical aspect of the global ocean circulation and the processes that affect it. We are in the midst of conducting a major next-generation experiment, coupling hydrographic/lowered ADCP and microstructure profiler measurements with simultaneous high-resolution profiling moorings and detailed numerical simulations. Our goals are to: (1) quantify the flow and its pathways through the SP, and compare them to measurements made 20 years ago as part of the World Ocean Circulation Experiment (WOCE), 2) quantify, with direct measurements, the turbulence and mixing the flow undergoes and the processes that lead to it, and 3) use the resulting knowledge to determine the best strategy for future monitoring of the SP. Here we present initial results from the first two of the experiment's three cruises, which have provided a detailed view of the flow magnitude, pathways and turbulence as it transits the passage's sills. Bathymetry, stratification, rotation, and inertia all play important roles in selecting the pathways taken by the flow, with the lighter layers siphoning off through the shallower sills to the west and the densest water following the deeper main eastern channel. Flows in this main channel are initially O(0.1 m/s), accelerating to > 0.4 m/s at the northernmost of the two major sills, leading to strong shears and warming of the bottom water from 0.66 to 0.72 C through mixing within the stratified overflow and entrainment of overlying water. Direct microstructure measurements show large vertical diffusivities of 10^{-4}-10^{-3} m^2/s throughout the passage and up to 10^{-2} m^2/s past the northern sill, where the flow

  13. Alkaline flooding injection strategy

    SciTech Connect

    French, T.R.; Josephson, C.B.

    1992-03-01

    The objective of this project is to improved alkali-surfactant flooding methods, and this includes determining the proper design of injection strategy. Several different injection strategies have been used or suggested for recovering heavy oils with surfactant-enhanced alkaline flooding methods. Oil recovery was compared for four different injection strategies: (1) surfactant followed by polymer, (2) surfactant followed by alkaline polymer, (3) alkaline surfactant followed by polymer, and (4) alkali, surfactant, and polymer mixed in a single formulation. The effect of alkaline preflush was also studied under two different conditions. All of the oil recovery experiments were conducted under optimal conditions with a viscous, non-acidic oil from Hepler (KS) oil field. The coreflood experiments were conducted with Berea sandstone cores since field core was not available in sufficient quantity for coreflood tests. The Tucker sand of Hepler field is a Class I fluvial dominated deltaic reservoir, as classified by the Department of Energy, which has been selected as the site of a DOE-sponsored field pilot test.

  14. Mixed-Strain Mycobacterium tuberculosis Infections and the Implications for Tuberculosis Treatment and Control

    PubMed Central

    van Helden, Paul D.; Wilson, Douglas; Colijn, Caroline; McLaughlin, Megan M.; Abubakar, Ibrahim; Warren, Robin M.

    2012-01-01

    Summary: Numerous studies have reported that individuals can simultaneously harbor multiple distinct strains of Mycobacterium tuberculosis. To date, there has been limited discussion of the consequences for the individual or the epidemiological importance of mixed infections. Here, we review studies that documented mixed infections, highlight challenges associated with the detection of mixed infections, and discuss possible implications of mixed infections for the diagnosis and treatment of patients and for the community impact of tuberculosis control strategies. We conclude by highlighting questions that should be resolved in order to improve our understanding of the importance of mixed-strain M. tuberculosis infections. PMID:23034327

  15. Serotonin Transporter Gene (SLC6A4) Polymorphism and Mucosal Serotonin Levels in Southeastern Iranian Patients with Irritable Bowel Syndrome

    PubMed Central

    Mohammadi, Mojgan; Tahmasebi Abdar, Hossein; Mollaei, Hamid Reza; Hajghani, Hossein; Baneshi, Mohammad Reza; Hayatbakhsh, Mohammad Mahdi

    2017-01-01

    BACKGROUND Irritable bowel syndrome (IBS) is a digestive system disorder with an unknown etiology. Serotonin has a key role in the secretion and motility of the intestine. Polymorphism in serotonin re-uptake transporter (SERT or SLC6A4) gene may have a functional role in the gut of patients with IBS. The aims of the present study were to investigate the association between SLC6A4 gene polymorphism and IBS and to detect the correlation between rectal serotonin levels and IBS sub-types. METHODS SLC6A4 gene polymorphism in 131 patients with IBS and 211 healthy controls were analysed using the quantitative polymerase chain reaction high-resolution melting (qPCR-HRM) curve technique. Serotonin was measured in rectal biopsies of patients with IBS using the enzyme-linked immunosorbent assay (ELISA) method. RESULTS The patients were categorized into three groups: IBS with diarrhoea (IBS-D): 70 patients, IBS with constipation (IBS-C): 18 patients, and IBS with mixed symptoms (IBS-M): 43 patients. The frequency of SLC6A4 s/s and l/s genotypes was significantly higher in IBS-C than IBS-D, IBS-M, and controls (p=0.036). Serotonin levels were similar in IBS sub-types. CONCLUSION SLC6A4 polymorphism is a possible candidate gene associated with the pathogenesis of IBS-C. Although serotonin levels did not differ in rectal biopsies of IBS sub-types, further investigation is recommended.

  16. Mixed and Low-Level Treatment Facility Project

    SciTech Connect

    Not Available

    1992-04-01

    This appendix contains the mixed and low-level waste engineering design files (EDFS) documenting each low-level and mixed waste stream investigated during preengineering studies for Mixed and Low-Level Waste Treatment Facility Project. The EDFs provide background information on mixed and low-level waste generated at the Idaho National Engineering Laboratory. They identify, characterize, and provide treatment strategies for the waste streams. Mixed waste is waste containing both radioactive and hazardous components as defined by the Atomic Energy Act and the Resource Conservation and Recovery Act, respectively. Low-level waste is waste that contains radioactivity and is not classified as high-level waste, transuranic waste, spent nuclear fuel, or 11e(2) byproduct material as defined by DOE 5820.2A. Test specimens of fissionable material irradiated for research and development only, and not for the production of power or plutonium, may be classified as low-level waste, provided the concentration of transuranic is less than 100 nCi/g. This appendix is a tool that clarifies presentation format for the EDFS. The EDFs contain waste stream characterization data and potential treatment strategies that will facilitate system tradeoff studies and conceptual design development. A total of 43 mixed waste and 55 low-level waste EDFs are provided.

  17. Mixed methods, mixed methodology health services research in practice.

    PubMed

    Johnstone, P Lynne

    2004-02-01

    Mixed methods, mixed methodology research is a little documented but increasingly accepted approach employed to investigate organizational phenomena. The author presents a synthesis of literature that informed the decision to adopt a mixed methods, mixed methodology, dominantly naturalistic study approach to health services research in which she explored the process and organizational consequences of new artifact adoption in surgery. She describes the way whereby a collective case study involving five Australian hospitals yielded quantitative and qualitative data that were analyzed using inductive and/or deductive reasoning. She goes beyond the theoretical rational for employing a mixed methods, mixed methodology approach to present a summative conceptual model of the research process and describe the structural aspects of the dissertation in which the research was reported that should benefit researchers contemplating the value of such an approach.

  18. Mixed Mode Matrix Multiplication

    SciTech Connect

    Meng-Shiou Wu; Srinivas Aluru; Ricky A. Kendall

    2004-09-30

    In modern clustering environments where the memory hierarchy has many layers (distributed memory, shared memory layer, cache,...), an important question is how to fully utilize all available resources and identify the most dominant layer in certain computations. When combining algorithms on all layers together, what would be the best method to get the best performance out of all the resources we have? Mixed mode programming model that uses thread programming on the shared memory layer and message passing programming on the distributed memory layer is a method that many researchers are using to utilize the memory resources. In this paper, they take an algorithmic approach that uses matrix multiplication as a tool to show how cache algorithms affect the performance of both shared memory and distributed memory algorithms. They show that with good underlying cache algorithm, overall performance is stable. When underlying cache algorithm is bad, superlinear speedup may occur, and an increasing number of threads may also improve performance.

  19. Radioactive mixed waste disposal

    SciTech Connect

    Jasen, W.G.; Erpenbeck, E.G.

    1993-02-01

    Various types of waste have been generated during the 50-year history of the Hanford Site. Regulatory changes in the last 20 years have provided the emphasis for better management of these wastes. Interpretations of the Atomic Energy Act of 1954 (AEA), the Resource Conservation and Recovery Act of 1976 (RCRA), and the Hazardous and Solid Waste Amendments (HSWA) have led to the definition of radioactive mixed wastes (RMW). The radioactive and hazardous properties of these wastes have resulted in the initiation of special projects for the management of these wastes. Other solid wastes at the Hanford Site include low-level wastes, transuranic (TRU), and nonradioactive hazardous wastes. This paper describes a system for the treatment, storage, and disposal (TSD) of solid radioactive waste.

  20. Strategies Unlimited.

    ERIC Educational Resources Information Center

    Blaga, Jeff; And Others

    Designed primarily for teachers of students in grades 7-12, the document presents over 60 social studies teaching strategies and lesson plans. Each lesson includes an overview, grade level information, suggested course/subject matter uses, objectives, suggested materials, student materials, and an instructional plan. Lesson topics fall into the…

  1. Biogenic inputs to ocean mixing.

    PubMed

    Katija, Kakani

    2012-03-15

    Recent studies have evoked heated debate about whether biologically generated (or biogenic) fluid disturbances affect mixing in the ocean. Estimates of biogenic inputs have shown that their contribution to ocean mixing is of the same order as winds and tides. Although these estimates are intriguing, further study using theoretical, numerical and experimental techniques is required to obtain conclusive evidence of biogenic mixing in the ocean. Biogenic ocean mixing is a complex problem that requires detailed understanding of: (1) marine organism behavior and characteristics (i.e. swimming dynamics, abundance and migratory behavior), (2) mechanisms utilized by swimming animals that have the ability to mix stratified fluids (i.e. turbulence and fluid drift) and (3) knowledge of the physical environment to isolate contributions of marine organisms from other sources of mixing. In addition to summarizing prior work addressing the points above, observations on the effect of animal swimming mode and body morphology on biogenic fluid transport will also be presented. It is argued that to inform the debate on whether biogenic mixing can contribute to ocean mixing, our studies should focus on diel vertical migrators that traverse stratified waters of the upper pycnocline. Based on our understanding of mixing mechanisms, body morphologies, swimming modes and body orientation, combined with our knowledge of vertically migrating populations of animals, it is likely that copepods, krill and some species of gelatinous zooplankton and fish have the potential to be strong sources of biogenic mixing.

  2. Fluid mixing in stratified gravity currents: the Prandtl mixing length.

    PubMed

    Odier, P; Chen, J; Rivera, M K; Ecke, R E

    2009-04-03

    Shear-induced vertical mixing in a stratified flow is a key ingredient of thermohaline circulation. We experimentally determine the vertical flux of momentum and density of a forced gravity current using high-resolution velocity and density measurements. A constant eddy-viscosity model provides a poor description of the physics of mixing, but a Prandtl mixing length model relating momentum and density fluxes to mean velocity and density gradients works well. For the average gradient Richardson number Ri(g) approximately 0.08 and a Taylor Reynolds number Re(lambda) approximately 100, the mixing lengths are fairly constant, about the same magnitude, comparable to the turbulent shear length.

  3. Mixed and Low-Level Treatment Facility Project. Appendix B, Waste stream engineering files, Part 1, Mixed waste streams

    SciTech Connect

    Not Available

    1992-04-01

    This appendix contains the mixed and low-level waste engineering design files (EDFS) documenting each low-level and mixed waste stream investigated during preengineering studies for Mixed and Low-Level Waste Treatment Facility Project. The EDFs provide background information on mixed and low-level waste generated at the Idaho National Engineering Laboratory. They identify, characterize, and provide treatment strategies for the waste streams. Mixed waste is waste containing both radioactive and hazardous components as defined by the Atomic Energy Act and the Resource Conservation and Recovery Act, respectively. Low-level waste is waste that contains radioactivity and is not classified as high-level waste, transuranic waste, spent nuclear fuel, or 11e(2) byproduct material as defined by DOE 5820.2A. Test specimens of fissionable material irradiated for research and development only, and not for the production of power or plutonium, may be classified as low-level waste, provided the concentration of transuranic is less than 100 nCi/g. This appendix is a tool that clarifies presentation format for the EDFS. The EDFs contain waste stream characterization data and potential treatment strategies that will facilitate system tradeoff studies and conceptual design development. A total of 43 mixed waste and 55 low-level waste EDFs are provided.

  4. Target marketing strategies for occupational therapy entrepreneurs.

    PubMed

    Kautzmann, L N; Kautzmann, F N; Navarro, F H

    1989-01-01

    Understanding marketing techniques is one of the skills needed by successful entre renews. Target marketing is an effective method for occupational therapy entrepreneurs to use in determining when and where to enter the marketplace. The two components of target marketing, market segmentation and the development of marketing mix strategies for each identified market segment, are described. The Profife of Attitudes Toward Health Care (PATH) method of psychographic market segmentation of health care consumers is presented. Occupational therapy marketing mix strategies for each PATH consumer group are delineated and compatible groupings of market segments are suggested.

  5. Perfect mixing of immiscible macromolecules at fluid interfaces

    NASA Astrophysics Data System (ADS)

    Sheiko, Sergei; Matyjaszewski, Krzysztof; Tsukruk, Vladimir; Carrillo, Jan-Michael; Rubinstein, Michael; Dobrynin, Andrey; Zhou, Jing

    2014-03-01

    Macromolecules typically phase separate unless their shapes and chemical compositions are tailored to explicitly drive mixing. But now our research has shown that physical constraints can drive spontaneous mixing of chemically different species. We have obtained long-range 2D arrays of perfectly mixed macromolecules having a variety of molecular architectures and chemistries, including linear chains, block-copolymer stars, and bottlebrush copolymers with hydrophobic, hydrophilic, and lipophobic chemical compositions. This is achieved by entropy-driven enhancement of steric repulsion between macromolecules anchored on a substrate. By monitoring the kinetics of mixing, we have proved that molecular intercalation is an equilibrium state. The array spacing is controlled by the length of the brush side chains. This entropic templating strategy opens new ways for generating patterns on sub-100 nm length scales with potential application in lithography, directed self-assembly, and biomedical assays. Financial support from the National Science Foundation DMR-0906985, DMR-1004576, DMR-1122483, and DMR-0907515.

  6. Estimating beta-mixing coefficients

    PubMed Central

    McDonald, Daniel J.; Shalizi, Cosma Rohilla; Schervish, Mark

    2015-01-01

    The literature on statistical learning for time series assumes the asymptotic independence or “mixing” of the data-generating process. These mixing assumptions are never tested, and there are no methods for estimating mixing rates from data. We give an estimator for the beta-mixing rate based on a single stationary sample path and show it is L1-risk consistent. PMID:26279742

  7. Optimal broadcasting of mixed states

    SciTech Connect

    Dang Guifang; Fan Heng

    2007-08-15

    The N to M (M{>=}N) universal quantum broadcasting of mixed states {rho}{sup xN} is proposed for a qubit system. The broadcasting of mixed states is universal and optimal in the sense that the shrinking factor is independent of the input state and achieves the upper bound. The quantum broadcasting of mixed qubits is a generalization of the universal quantum cloning machine for identical pure input states. A pure state decomposition of the identical mixed qubits {rho}{sup xN} is obtained.

  8. Overview of Neutrino Mixing Models and Their Mixing Angle Predictions

    SciTech Connect

    Albright, Carl H.

    2009-11-01

    An overview of neutrino-mixing models is presented with emphasis on the types of horizontal flavor and vertical family symmetries that have been invoked. Distributions for the mixing angles of many models are displayed. Ways to differentiate among the models and to narrow the list of viable models are discussed.

  9. The influence of opening statement/closing argument organizational strategy on juror verdict and damage awards.

    PubMed

    Spiecker, Shelley C; Worthington, Debra L

    2003-08-01

    This study examines the influence of the organizational strategy used to structure opening statements and closing arguments on presentation effectiveness in a simulated civil trial. Two organizational structures, a narrative and a legal-expository format, were manipulated to produce a 2 (plaintiff organizational strategy) x 3 (defense organizational strategy) experimental design. Results indicate that a mixed organizational strategy (narrative opening/legal-expository closing) is more effective for the plaintiff than a strict narrative strategy, and either a mixed or strict legal-expository organizational strategy is more effective than a strict narrative strategy for the defense.

  10. Mixed voltage VLSI design

    NASA Technical Reports Server (NTRS)

    Panwar, Ramesh; Rennels, David; Alkalaj, Leon

    1993-01-01

    A technique for minimizing the power dissipated in a Very Large Scale Integration (VLSI) chip by lowering the operating voltage without any significant penalty in the chip throughput even though low voltage operation results in slower circuits. Since the overall throughput of a VLSI chip depends on the speed of the critical path(s) in the chip, it may be possible to sustain the throughput rates attained at higher voltages by operating the circuits in the critical path(s) with a high voltage while operating the other circuits with a lower voltage to minimize the power dissipation. The interface between the gates which operate at different voltages is crucial for low power dissipation since the interface may possibly have high static current dissipation thus negating the gains of the low voltage operation. The design of a voltage level translator which does the interface between the low voltage and high voltage circuits without any significant static dissipation is presented. Then, the results of the mixed voltage design using a greedy algorithm on three chips for various operating voltages are presented.

  11. Mixed oxide fuel development

    SciTech Connect

    Leggett, R.D.; Omberg, R.P.

    1987-05-08

    This paper describes the success of the ongoing mixed-oxide fuel development program in the United States aimed at qualifying an economical fuel system for liquid metal cooled reactors. This development has been the cornerstone of the US program for the past 20 years and has proceeded in a deliberate and highly disciplined fashion with high emphasis on fuel reliability and operational safety as major features of an economical fuel system. The program progresses from feature testing in EBR-II to qualifying full size components in FFTF under fully prototypic conditions to establish a basis for extending allowable lifetimes. The development program started with the one year (300 EFPD) core, which is the FFTF driver fuel, continued with the demonstration of a two year (600 EFPD) core and is presently evaluating a three year (900 EFPD) fuel system. All three of these systems, consistent with other LMR fuel programs around the world, use fuel pellets gas bonded to a cladding tube that is assembled into a bundle and fitted into a wrapper tube or duct for ease of insertion into a core. The materials of construction progressed from austenitic CW 316 SS to lower swelling austenitic D9 to non swelling ferritic/martensitic HT9. 6 figs., 2 tabs.

  12. Saporin-S6: A Useful Tool in Cancer Therapy

    PubMed Central

    Polito, Letizia; Bortolotti, Massimo; Mercatelli, Daniele; Battelli, Maria Giulia; Bolognesi, Andrea

    2013-01-01

    Thirty years ago, the type 1 ribosome-inactivating protein (RIP) saporin-S6 (also known as saporin) was isolated from Saponaria officinalis L. seeds. Since then, the properties and mechanisms of action of saporin-S6 have been well characterized, and it has been widely employed in the construction of conjugates and immunotoxins for different purposes. These immunotoxins have shown many interesting results when used in cancer therapy, particularly in hematological tumors. The high enzymatic activity, stability and resistance to conjugation procedures and blood proteases make saporin-S6 a very useful tool in cancer therapy. High efficacy has been reported in clinical trials with saporin-S6-containing immunotoxins, at dosages that induced only mild and transient side effects, which were mainly fever, myalgias, hepatotoxicity, thrombocytopenia and vascular leak syndrome. Moreover, saporin-S6 triggers multiple cell death pathways, rendering impossible the selection of RIP-resistant mutants. In this review, some aspects of saporin-S6, such as the chemico-physical characteristics, the structural properties, its endocytosis, its intracellular routing and the pathogenetic mechanisms of the cell damage, are reported. In addition, the recent progress and developments of saporin-S6-containing immunotoxins in cancer immunotherapy are summarized, including in vitro and in vivo pre-clinical studies and clinical trials. PMID:24105401

  13. Anomalous Sediment Mixing by Bioturbation

    NASA Astrophysics Data System (ADS)

    Roche, K. R.; Aubeneau, A. F.; Xie, M.; Packman, A. I.

    2013-12-01

    Bioturbation, the reworking of sediments by animals and plants, is the dominant mode of sediment mixing in low-energy environments, and plays an important role in sedimentary biogeochemical processes. Mixing resulting from bioturbation has historically been modeled as a diffusive process. However, diffusion models often do not provide a sufficient description of sediment mixing due to bioturbation. Stochastic models, such as the continuous time random walk (CTRW) model, provide more general descriptions of mixing behavior that are applicable even when regular diffusion assumptions are not met. Here we present results from an experimental investigation of anomalous sediment mixing by bioturbation in freshwater sediments. Clean and heavy-metal-contaminated sediments were collected from Lake DePue, a backwater lake of the Illinois River. The burrowing worm species Lumbriculus variegatus was introduced to homogenized Lake DePue sediments in aerated aquaria. We then introduced inert fine fluorescent particles to the sediment-water interface. Using time-lapse photography, we observed the mixing of the fluorescent particles into the sediment bed over a two-week period. We developed image analysis software to characterize the concentration distribution of the fluorescent particles as a function of sediment depth, and applied this to the time-series of images to evaluate sediment mixing. We fit a one-dimensional CTRW model to the depth profiles to evaluate the underlying statistical properties of the mixing behavior. This analysis suggests that the sediment mixing caused by L. variegatus burrowing is subdiffusive in time and superdiffusive in space. We also found that heavy metal contamination significantly reduces L. variegatus burrowing, causing increasingly anomalous sediment mixing. This result implies that there can be important feedbacks between sediment chemistry, organism behavior, and sediment mixing that are not considered in current environmental models.

  14. Microfluidic mixing using contactless dielectrophoresis.

    PubMed

    Salmanzadeh, Alireza; Shafiee, Hadi; Davalos, Rafael V; Stremler, Mark A

    2011-09-01

    The first experimental evidence of mixing enhancement in a microfluidic system using contactless dielectrophoresis (cDEP) is presented in this work. Pressure-driven flow of deionized water containing 0.5 μm beads was mixed in various chamber geometries by imposing a dielectrophoresis (DEP) force on the beads. In cDEP the electrodes are not in direct contact with the fluid sample but are instead capacitively coupled to the mixing chamber through thin dielectric barriers, which eliminates many of the problems encountered with standard DEP. Four system designs with rectangular and circular mixing chambers were fabricated in PDMS. Mixing tests were conducted for flow rates from 0.005 to 1 mL/h subject to an alternating current signal range of 0-300 V at 100-600 kHz. When the time scales of the bulk fluid motion and the DEP motion were commensurate, rapid mixing was observed. The rectangular mixing chambers were found to be more efficient than the circular chambers. This approach shows potential for mixing low diffusivity biological samples, which is a very challenging problem in laminar flows at small scales.

  15. Mixed Waste Working Group report

    SciTech Connect

    Not Available

    1993-11-09

    The treatment of mixed waste remains one of this country`s most vexing environmental problems. Mixed waste is the combination of radioactive waste and hazardous waste, as defined by the Resource Conservation and Recovery Act (RCRA). The Department of Energy (DOE), as the country`s largest mixed waste generator, responsible for 95 percent of the Nation`s mixed waste volume, is now required to address a strict set of milestones under the Federal Facility Compliance Act of 1992. DOE`s earlier failure to adequately address the storage and treatment issues associated with mixed waste has led to a significant backlog of temporarily stored waste, significant quantities of buried waste, limited permanent disposal options, and inadequate treatment solutions. Between May and November of 1993, the Mixed Waste Working Group brought together stakeholders from around the Nation. Scientists, citizens, entrepreneurs, and bureaucrats convened in a series of forums to chart a course for accelerated testing of innovative mixed waste technologies. For the first time, a wide range of stakeholders were asked to examine new technologies that, if given the chance to be tested and evaluated, offer the prospect for better, safer, cheaper, and faster solutions to the mixed waste problem. In a matter of months, the Working Group has managed to bridge a gap between science and perception, engineer and citizen, and has developed a shared program for testing new technologies.

  16. Mixed and Low-Level Waste Treatment Facility project

    SciTech Connect

    Not Available

    1992-04-01

    Mixed and low-level wastes generated at the Idaho National Engineering Laboratory (INEL) are required to be managed according to applicable State and Federal regulations, and Department of Energy Orders that provide for the protection of human health and the environment. The Mixed and Low-Level Waste Treatment Facility Project was chartered in 1991, by the Department of Energy to provide treatment capability for these mixed and low-level waste streams. The first project task consisted of conducting engineering studies to identify the waste streams, their potential treatment strategies, and the requirements that would be imposed on the waste streams and the facilities used to process them. The engineering studies, initiated in July 1991, identified 37 mixed waste streams, and 55 low-level waste streams. This report documents the waste stream information and potential treatment strategies, as well as the regulatory requirements for the Department of Energy-owned treatment facility option. The total report comprises three volumes and two appendices. This report consists of Volume 1, which explains the overall program mission, the guiding assumptions for the engineering studies, and summarizes the waste stream and regulatory information, and Volume 2, the Waste Stream Technical Summary which, encompasses the studies conducted to identify the INEL's waste streams and their potential treatment strategies.

  17. m6A-Driver: Identifying Context-Specific mRNA m6A Methylation-Driven Gene Interaction Networks

    PubMed Central

    Zhang, Song-Yao; Zhang, Shao-Wu; Liu, Lian; Huang, Yufei

    2016-01-01

    As the most prevalent mammalian mRNA epigenetic modification, N6-methyladenosine (m6A) has been shown to possess important post-transcriptional regulatory functions. However, the regulatory mechanisms and functional circuits of m6A are still largely elusive. To help unveil the regulatory circuitry mediated by mRNA m6A methylation, we develop here m6A-Driver, an algorithm for predicting m6A-driven genes and associated networks, whose functional interactions are likely to be actively modulated by m6A methylation under a specific condition. Specifically, m6A-Driver integrates the PPI network and the predicted differential m6A methylation sites from methylated RNA immunoprecipitation sequencing (MeRIP-Seq) data using a Random Walk with Restart (RWR) algorithm and then builds a consensus m6A-driven network of m6A-driven genes. To evaluate the performance, we applied m6A-Driver to build the context-specific m6A-driven networks for 4 known m6A (de)methylases, i.e., FTO, METTL3, METTL14 and WTAP. Our results suggest that m6A-Driver can robustly and efficiently identify m6A-driven genes that are functionally more enriched and associated with higher degree of differential expression than differential m6A methylated genes. Pathway analysis of the constructed context-specific m6A-driven gene networks further revealed the regulatory circuitry underlying the dynamic interplays between the methyltransferases and demethylase at the epitranscriptomic layer of gene regulation. PMID:28027310

  18. Mixed connective tissue disease.

    PubMed

    Gunnarsson, Ragnar; Hetlevik, Siri Opsahl; Lilleby, Vibke; Molberg, Øyvind

    2016-02-01

    The concept of mixed connective tissue disease (MCTD) as a separate connective tissue disease (CTD) has persisted for more than four decades. High titers of antibodies targeting the U1 small nuclear ribonucleoprotein particle (U1 snRNP) in peripheral blood are a sine qua non for the diagnosis of MCTD, in addition to distinct clinical features including Raynaud's phenomenon (RP), "puffy hands," arthritis, myositis, pleuritis, pericarditis, interstitial lung disease (ILD), and pulmonary hypertension (PH). Recently, population-based epidemiology data from Norway estimated the point prevalence of adult-onset MCTD to be 3.8 per 100,000 and the mean annual incidence to be 2.1 per million per year, supporting the notion that MCTD is the least common CTD. Little is known about the etiology of MCTD, but recent genetic studies have confirmed that MCTD is a strongly HLA (​human leukocyte antigen)-linked disease, as the HLA profiles of MCTD differ distinctly from the corresponding profiles of ethnically matched healthy controls and other CTDs. In the first section of this review, we provide an update on the clinical, immunological, and genetic features of MCTD and discuss the relationship between MCTD and the other CTDs. Then we proceed to discuss the recent advances in therapy and our current understanding of prognosis and prognostic factors, especially those that are associated with the more serious pulmonary and cardiovascular complications of the disease. In the final section, we discuss some of the key, unresolved questions related to anti-RNP-associated diseases and indicate how these questions may be approached in future studies.

  19. Biomass conversion to mixed alcohols

    SciTech Connect

    Holtzapple, M.T.; Loescher, M.; Ross, M.

    1996-10-01

    This paper discusses the MixAlco Process which converts a wide variety of biomass materials (e.g. municipal solid waste, sewage sludge, agricultural residues) to mixed alcohols. First, the biomass is treated with lime to enhance its digestibility. Then, a mixed culture of acid-forming microorganisms converts the lime-treated biomass to volatile fatty acids (VFA) such as acetic, propionic, and butyric acids. To maintain fermentor pH, a neutralizing agent (e.g. calcium carbonate or lime) is added, so the fermentation actually produces VFA salts such as calcium acetate, propionate, and butyrate. The VFA salts are recovered and thermally converted to ketones (e.g. acetone, methylethyl ketone, diethyl ketone) which are subsequently hydrogenated to mixed alcohols (e.g. isopropanol, isobutanol, isopentanol). Processing costs are estimated at $0.72/gallon of mixed alcohols making it potentially attractive for transportation fuels.

  20. Mixing in confined stratified aquifers

    NASA Astrophysics Data System (ADS)

    Bolster, Diogo; Valdés-Parada, Francisco J.; LeBorgne, Tanguy; Dentz, Marco; Carrera, Jesus

    2011-03-01

    Spatial variability in a flow field leads to spreading of a tracer plume. The effect of microdispersion is to smooth concentration gradients that exist in the system. The combined effect of these two phenomena leads to an 'effective' enhanced mixing that can be asymptotically quantified by an effective dispersion coefficient (i.e. Taylor dispersion). Mixing plays a fundamental role in driving chemical reactions. However, at pre-asymptotic times it is considerably more difficult to accurately quantify these effects by an effective dispersion coefficient as spreading and mixing are not the same (but intricately related). In this work we use a volume averaging approach to calculate the concentration distribution of an inert solute release at pre-asymptotic times in a stratified formation. Mixing here is characterized by the scalar dissipation rate, which measures the destruction of concentration variance. As such it is an indicator for the degree of mixing of a system. We study pre-asymptotic solute mixing in terms of explicit analytical expressions for the scalar dissipation rate and numerical random walk simulations. In particular, we divide the concentration field into a mean and deviation component and use dominant balance arguments to write approximate governing equations for each, which we then solve analytically. This allows us to explicitly evaluate the separate contributions to mixing from the mean and the deviation behavior. We find an approximate, but accurate expression (when compared to numerical simulations) to evaluate mixing. Our results shed some new light on the mechanisms that lead to large scale mixing and allow for a distinction between solute spreading, represented by the mean concentration, and mixing, which comes from both the mean and deviation concentrations, at pre-asymptotic times.

  1. Baroclinic mixing in HE fireballs

    SciTech Connect

    Kuhl, A.L.; Ferguson, R.E.; Priolo, F.; Chien, K.Y.; Collins, J.P.

    1993-08-01

    Numerical simulations of the turbulent mixing in the fireball of an HE blast wave were performed with a second-order Godunov code. Adaptive mesh refinement was used to capture the convective mixing processes on the computational grid. The calculations revealed that the interface between the shock-compressed air and the dense detonation products was unstable. Vorticity was generated in that region by baroclinic effects. This caused the interface to roll-up into a turbulent mixing layer. Four phases of mixing were identified: a strong blast wave phase, where the mixing region was swept outward by the shockinduced flow; an implosion phase, that stretched the inner boundary of the mixing region back toward the origin; a re-shocking phase, where the imploding shock expands back outward from the origin and re-energizes the mixing later by RichtmyerMeshkov effects; and an asymptotic mixing phase, where line-scale structures are continually recreated by folding effects but the overall vorticity decays through a cascade process. The flowfield was azimuthally averaged to evaluate the mean-flow profiles and r.m.s. fluctuation profiles across the mixing layer. The mean kinetic energy rapidly approached zero as the blast wave decayed, but the fluctuating kinetic energy asymptotically approached a small constant value. This represents the rotational kinetic energy driven by the vorticity field, that continued to mix the fluid at late times. It was shown that the vorticity field corresponds to a function that fluctuates between plus and minus values-with a volume-averaged mean of zero.

  2. Compressibility effects on turbulent mixing

    NASA Astrophysics Data System (ADS)

    Panickacheril John, John; Donzis, Diego

    2016-11-01

    We investigate the effect of compressibility on passive scalar mixing in isotropic turbulence with a focus on the fundamental mechanisms that are responsible for such effects using a large Direct Numerical Simulation (DNS) database. The database includes simulations with Taylor Reynolds number (Rλ) up to 100, turbulent Mach number (Mt) between 0.1 and 0.6 and Schmidt number (Sc) from 0.5 to 1.0. We present several measures of mixing efficiency on different canonical flows to robustly identify compressibility effects. We found that, like shear layers, mixing is reduced as Mach number increases. However, data also reveal a non-monotonic trend with Mt. To assess directly the effect of dilatational motions we also present results with both dilatational and soleniodal forcing. Analysis suggests that a small fraction of dilatational forcing decreases mixing time at higher Mt. Scalar spectra collapse when normalized by Batchelor variables which suggests that a compressive mechanism similar to Batchelor mixing in incompressible flows might be responsible for better mixing at high Mt and with dilatational forcing compared to pure solenoidal mixing. We also present results on scalar budgets, in particular on production and dissipation. Support from NSF is gratefully acknowledged.

  3. Mixed features in bipolar disorder.

    PubMed

    Solé, Eva; Garriga, Marina; Valentí, Marc; Vieta, Eduard

    2016-12-29

    Mixed affective states, defined as the coexistence of depressive and manic symptoms, are complex presentations of manic-depressive illness that represent a challenge for clinicians at the levels of diagnosis, classification, and pharmacological treatment. The evidence shows that patients with bipolar disorder who have manic/hypomanic or depressive episodes with mixed features tend to have a more severe form of bipolar disorder along with a worse course of illness and higher rates of comorbid conditions than those with non-mixed presentations. In the updated Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5), the definition of "mixed episode" has been removed, and subthreshold nonoverlapping symptoms of the opposite pole are captured using a "with mixed features" specifier applied to manic, hypomanic, and major depressive episodes. However, the list of symptoms proposed in the DSM-5 specifier has been widely criticized, because it includes typical manic symptoms (such as elevated mood and grandiosity) that are rare among patients with mixed depression, while excluding symptoms (such as irritability, psychomotor agitation, and distractibility) that are frequently reported in these patients. With the new classification, mixed depressive episodes are three times more common in bipolar II compared with unipolar depression, which partly contributes to the increased risk of suicide observed in bipolar depression compared to unipolar depression. Therefore, a specific diagnostic category would imply an increased diagnostic sensitivity, would help to foster early identification of symptoms and ensure specific treatment, as well as play a role in suicide prevention in this population.

  4. Mapping the Mixed Methods–Mixed Research Synthesis Terrain

    PubMed Central

    Sandelowski, Margarete; Voils, Corrine I.; Leeman, Jennifer; Crandell, Jamie L.

    2012-01-01

    Mixed methods–mixed research synthesis is a form of systematic review in which the findings of qualitative and quantitative studies are integrated via qualitative and/or quantitative methods. Although methodological advances have been made, efforts to differentiate research synthesis methods have been too focused on methods and not focused enough on the defining logics of research synthesis—each of which may be operationalized in different ways—or on the research findings themselves that are targeted for synthesis. The conduct of mixed methods–mixed research synthesis studies may more usefully be understood in terms of the logics of aggregation and configuration. Neither logic is preferable to the other nor tied exclusively to any one method or to any one side of the qualitative/quantitative binary. PMID:23066379

  5. Mixed deterministic and probabilistic networks.

    PubMed

    Mateescu, Robert; Dechter, Rina

    2008-11-01

    The paper introduces mixed networks, a new graphical model framework for expressing and reasoning with probabilistic and deterministic information. The motivation to develop mixed networks stems from the desire to fully exploit the deterministic information (constraints) that is often present in graphical models. Several concepts and algorithms specific to belief networks and constraint networks are combined, achieving computational efficiency, semantic coherence and user-interface convenience. We define the semantics and graphical representation of mixed networks, and discuss the two main types of algorithms for processing them: inference-based and search-based. A preliminary experimental evaluation shows the benefits of the new model.

  6. Mixed deterministic and probabilistic networks

    PubMed Central

    Dechter, Rina

    2010-01-01

    The paper introduces mixed networks, a new graphical model framework for expressing and reasoning with probabilistic and deterministic information. The motivation to develop mixed networks stems from the desire to fully exploit the deterministic information (constraints) that is often present in graphical models. Several concepts and algorithms specific to belief networks and constraint networks are combined, achieving computational efficiency, semantic coherence and user-interface convenience. We define the semantics and graphical representation of mixed networks, and discuss the two main types of algorithms for processing them: inference-based and search-based. A preliminary experimental evaluation shows the benefits of the new model. PMID:20981243

  7. [Marketing mix in health service].

    PubMed

    Ameri, Cinzia; Fiorini, Fulvio

    2015-01-01

    The marketing mix is the combination of the marketing variables that a firm employs with the purpose to achieve the expected volume of business within its market. In the sale of goods, four variables compose the marketing mix (4 Ps): Product, Price, Point of sale and Promotion. In the case of providing services, three further elements play a role: Personnel, Physical Evidence and Processes (7 Ps). The marketing mix must be addressed to the consumers as well as to the employees of the providing firm. Furthermore, it must be interpreted as employees ability to satisfy customers (interactive marketing).

  8. Waveguide Four-Wave Mixing

    DTIC Science & Technology

    1991-10-01

    PL-TR--91-1045 /’--"PL-TR-- AD-A243 555 91-1045 WAVEGUIDE FOUR -WAVE MIXING Thomas B. Simpson Jia-ming Liu JAYCOR San Diego, CA 92186-5154 October...Final Report; May 88 - Mar 91 4. TITLE AND SUBTITLE 5. FUNDING NUMBERS WAVEGUIDE FOUR -WAVE MIXING C: F29601-88-C-0023 PE: 62601F PR: 3326 6. AUTHOR(S...for public release; distribution unlimited. 13. ABSTRACT (Maximum 200 words) This program has investigated four -wave mixing (4-win) in non- linear

  9. Biodegradation of mixed pesticides by mixed pesticide enriched cultures.

    PubMed

    Krishna, K Rama; Philip, Ligy

    2009-01-01

    This paper discusses the degradation kinetics of mixed (lindane, methyl parathion and carbofuran) pesticides by mixed pesticide enriched cultures (MEC) under various environmental conditions. The bacterial strains isolated from the mixed microbial consortium were identified as Pseudomonas aeruginosa (MTCC 9236), Bacillus sp. (MTCC 9235) and Chryseobacterium joostei (MTCC 9237). Batch studies were conducted to estimate the biokinetic parameters like the maximum specific growth rate (mu(max)), Yield Coefficient (Y(T)), half saturation concentration (K(s)) and inhibition concentration (Ki) for individual and mixed pesticide enriched cultures. The cultures enriched in a particular pollutant always showed high growth rate and low inhibition in that particular pollutant compared to MEC. After seven weeks of incubation, mixed pesticide enriched cultures were able to degrade 72% lindane, 95% carbofuran and 100% of methyl parathion in facultative co-metabolic conditions. In aerobic systems, degradation efficiencies of lindane methyl parathion and carbofuran were increased by the addition of 2g L(- 1) of dextrose. Though many metabolic compounds of mixed pesticides were observed at different time intervals, none of the metabolites were persistent. Based on the observed metabolites, a degradation pathway was postulated for different pesticides under various environmental conditions.

  10. Prediction of stock markets by the evolutionary mix-game model

    NASA Astrophysics Data System (ADS)

    Chen, Fang; Gou, Chengling; Guo, Xiaoqian; Gao, Jieping

    2008-06-01

    This paper presents the efforts of using the evolutionary mix-game model, which is a modified form of the agent-based mix-game model, to predict financial time series. Here, we have carried out three methods to improve the original mix-game model by adding the abilities of strategy evolution to agents, and then applying the new model referred to as the evolutionary mix-game model to forecast the Shanghai Stock Exchange Composite Index. The results show that these modifications can improve the accuracy of prediction greatly when proper parameters are chosen.

  11. Mixed Incontinence: How Best to Manage It?

    PubMed

    Porena, Massimo; Costantini, Elisabetta; Lazzeri, Massimo

    2013-03-01

    Although common in women, mixed urinary incontinence (MUI) is under-reported and under-treated. It is linked to concomitant disturbances, which may be due to childbirth, ageing, or other medical conditions, in the complex bladder-urethra coordinated system of urine storage and emptying. Primary care physicians can evaluate MUI through history and simple clinical assessment or they can avail of more complex device and tools, such as urodynamic assessment. There is a wide range of therapeutic options. The recent proliferation of new drug treatments and surgical devices for urinary incontinence offers innovative strategies for therapy but products risk being introduced without long-term safety and efficacy assessment. Direct-to-consumer advertising has increased public awareness of MUI.

  12. Modeling Mix in ICF Implosions

    NASA Astrophysics Data System (ADS)

    Weber, C. R.; Clark, D. S.; Chang, B.; Eder, D. C.; Haan, S. W.; Jones, O. S.; Marinak, M. M.; Peterson, J. L.; Robey, H. F.

    2014-10-01

    The observation of ablator material mixing into the hot spot of ICF implosions correlates with reduced yield in National Ignition Campaign (NIC) experiments. Higher Z ablator material radiatively cools the central hot spot, inhibiting thermonuclear burn. This talk focuses on modeling a ``high-mix'' implosion from the NIC, where greater than 1000 ng of ablator material was inferred to have mixed into the hot spot. Standard post-shot modeling of this implosion does not predict the large amounts of ablator mix necessary to explain the data. Other issues are explored in this talk and sensitivity to the method of radiation transport is found. Compared with radiation diffusion, Sn transport can increase ablation front growth and alter the blow-off dynamics of capsule dust. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

  13. Is the tribimaximal mixing accidental?

    SciTech Connect

    Abbas, Mohammed; Smirnov, A. Yu.

    2010-07-01

    The tribimaximal (TBM) mixing is not accidental if structures of the corresponding leptonic mass matrices follow immediately from certain (residual or broken) flavor symmetry. We develop a simple formalism which allows one to analyze effects of deviations of the lepton mixing from TBM on the structure of the neutrino mass matrix and on the underlying flavor symmetry. We show that possible deviations from the TBM mixing can lead to strong modifications of the mass matrix and strong violation of the TBM-mass relations. As a result, the mass matrix may have an 'anarchical' structure with random values of elements or it may have some symmetry that differs from the TBM symmetry. Interesting examples include matrices with texture zeros, matrices with certain 'flavor alignment' as well as hierarchical matrices with a two-component structure, where the dominant and subdominant contributions have different symmetries. This opens up new approaches to understanding the lepton mixing.

  14. Cutaneous mixed infections in AIDS.

    PubMed

    Piérard, G E; Piérard-Franchimont, C; Estrada, J A; Rurangirwa, A; Dosal, F L

    1990-02-01

    We report a new case of mixed infection occurring at the same site of the skin in a human immune deficiency virus-positive patient. Hyperkeratotic and crusted erosions contained fusospirochetal organisms, Cryptococcus neoformans, and another unidentified fungus.

  15. Mixed-mu superconducting bearings

    DOEpatents

    Hull, John R.; Mulcahy, Thomas M.

    1998-01-01

    A mixed-mu superconducting bearing including a ferrite structure disposed for rotation adjacent a stationary superconductor material structure and a stationary permanent magnet structure. The ferrite structure is levitated by said stationary permanent magnet structure.

  16. Mixed-mu superconducting bearings

    DOEpatents

    Hull, J.R.; Mulcahy, T.M.

    1998-03-03

    A mixed-mu superconducting bearing is disclosed including a ferrite structure disposed for rotation adjacent a stationary superconductor material structure and a stationary permanent magnet structure. The ferrite structure is levitated by said stationary permanent magnet structure. 9 figs.

  17. Mixed jamming method for SAR

    NASA Astrophysics Data System (ADS)

    Zhao, Hong-feng; Zhang, Peng; Wang, Yong-sheng

    2007-11-01

    The mixed jamming method of synthetic aperture radar is analyzed and discussed. The methods of active noise and deception jamming and the signal model of transmitting is described. The raw echo signal of SAR and the model of jammed echo signal are expatiated, the characteristic of SAR and the evaluating method of jamming effect are established. Finally, the mixed jamming imaging of SAR is simulated.

  18. Positive versus Negative Communication Strategies in Task-Based Learning

    ERIC Educational Resources Information Center

    Rohani, Siti

    2013-01-01

    This study aimed at describing how the implementation of Task-Based Learning (TBL) would shape or change students' use of oral communication strategies. Students' problems and strategies to solve the problems during the implementation of TBL were also explored. The study was a mixed method, employing both quantitative and qualitative analysis…

  19. No association of SLC6A3 and SLC6A4 gene polymorphisms with schizophrenia in the Han Chinese population.

    PubMed

    Yang, Beimeng; Huang, Xiaoye; Ruan, Liemin; Yu, Tao; Li, Xin; Jesse, Forrest Fabian; Cao, Yanfei; Li, Xingwang; Liu, Baocheng; Yang, Fengping; Lee, Yong-Seok; He, Lin; Li, Weidong; He, Guang

    2014-09-05

    The SLC6A3 and SLC6A4 genes are members of a class of neurotransmitter transporters for the release, re-uptake and recycling of neurotransmitters in synapses. SLC6A3 and SLC6A4 encode a dopamine transporter and serotonin transporter, respectively. Abnormal expression and genetic polymorphism of SLC6A3 and SLC6A4 genes may increase the risk of developing mental illness, such as schizophrenia, bipolar disorder, ADHD, and aggressive behavior in Alzheimer disease, etc. Nevertheless, association between SLC6A3, SLC6A4 genes polymorphism and schizophrenia patients have not been well studied in Han Chinese people. In this study, we examined whether single nucleotide polymorphisms (SNPs) in SLC6A3, SLC6A4 were associated with schizophrenia in Han Chinese people (893 schizophrenia patients and 611 healthy controls). No significant difference in allelic or genotypic frequency was found between schizophrenia patients and healthy controls. No positive linkage disequilibrium (LD) was detected either. No haplotypic distributions were positive. Accordingly, our study suggests that the 10 SNPs within both genes we examined do not play a major role in schizophrenia in the Han Chinese population.

  20. A Non-Fickian Mixing Model for Stratified Turbulent Flows

    DTIC Science & Technology

    2012-09-30

    center particle at each grid point and 4 satellite ones, displaced by 500 m along the four cardinal directions. Drifter trajectories were integrated...type of submesoscale instabilities exist, how they are connected to both larger scale and smaller scale motions, and to what extent they influence...been to model upper ocean mixed layer instabilities , investigate their behavior and try to develop sampling strategies using synthetic drifters and

  1. Dysphoric mania, mixed states, and mania with mixed features specifier: are we mixing things up?

    PubMed

    McElroy, Susan L; Keck, Paul E

    2016-11-21

    Various terms have been used to describe mania when it is accompanied by depressive symptoms. In this article, we attempt to define and discuss 3 of these terms: dysphoric mania, mixed state, and mania with mixed features specifier. We conclude that whatever term is used, it is important to be aware that mania is more often unpleasant than pleasant, and that the unpleasantness is not limited to depression.

  2. Creating and Supporting a Mixed Methods Health Services Research Team

    PubMed Central

    Bowers, Barbara; Cohen, Lauren W; Elliot, Amy E; Grabowski, David C; Fishman, Nancy W; Sharkey, Siobhan S; Zimmerman, Sheryl; Horn, Susan D; Kemper, Peter

    2013-01-01

    Objective. To use the experience from a health services research evaluation to provide guidance in team development for mixed methods research. Methods. The Research Initiative Valuing Eldercare (THRIVE) team was organized by the Robert Wood Johnson Foundation to evaluate The Green House nursing home culture change program. This article describes the development of the research team and provides insights into how funders might engage with mixed methods research teams to maximize the value of the team. Results. Like many mixed methods collaborations, the THRIVE team consisted of researchers from diverse disciplines, embracing diverse methodologies, and operating under a framework of nonhierarchical, shared leadership that required new collaborations, engagement, and commitment in the context of finite resources. Strategies to overcome these potential obstacles and achieve success included implementation of a Coordinating Center, dedicated time for planning and collaborating across researchers and methodologies, funded support for in-person meetings, and creative optimization of resources. Conclusions. Challenges are inevitably present in the formation and operation of effective mixed methods research teams. However, funders and research teams can implement strategies to promote success. PMID:24138774

  3. Active Control of Mixing and Combustion, from Mechanisms to Implementation

    NASA Astrophysics Data System (ADS)

    Ghoniem, Ahmed F.

    2001-11-01

    Implementation of active control in complex processes, of the type encountered in high Reynolds number mixing and combustion, is predicated upon the identification of the underlying mechanisms and the construction of reduced order models that capture their essential characteristics. The mechanisms of interest must be shown to be amenable to external actuations, allowing optimal control strategies to exploit the delicate interactions that lead to the desired outcome. Reduced order models are utilized in defining the form and requisite attributes of actuation, its relationship to the monitoring system and the relevant control algorithms embedded in a feedforward or a feedback loop. The talk will review recent work on active control of mixing in combustion devices in which strong shear zones concur with mixing, combustion stabilization and flame anchoring. The underlying mechanisms, e.g., stability of shear flows, formation/evolution of large vortical structures in separating and swirling flows, their mutual interactions with acoustic fields, flame fronts and chemical kinetics, etc., are discussed in light of their key roles in mixing, burning enhancement/suppression, and combustion instability. Subtle attributes of combustion mechanisms are used to suggest the requisite control strategies.

  4. Population strategy.

    PubMed

    Kunii, C

    1989-12-01

    In this article, Chojiro Kunii, chairman and executive director of the Japanese Organization for International Cooperation in Family Planning (JOICFP), briefly describes the evolution of the INtegrated Family Planning, Nutrition, and Parasite Control Project (IP). The IP project began in Japan during the post-war period, when midwives and public health nurses introduced family planning alongside maternal and child health care services to make it more acceptable to people. Based on Japan's experience, JOICFP formed an international cooperation project based on parasite control, family planning, and nutrition. Introduced in several Asian countries in the mid-1970s, the project was quickly transported to Central and South America. And in 1983, Africa witnesses its first IP project. This took place in the Masama district of Tanzania, where the results of deworming quickly captures the attention of the population, making it easier for family planning workers to spread their message. In the 2 regions where the IP project was introduced, contraceptive prevalence among women has increased from 9.3% to 33%, and from 27% to 60%. Tanzania is now considering incorporating the IP project in its next 5-year development plan. Other African countries have followed suit. Kunii explains that JOICFP's Ip project enjoys support from both IPPF and UNFPA. He adds that, for its 2nd stage of development, the IP project hopes to become a union of family planning and preventive health. This new phase can already be observed in Asian countries. In developing its population strategy, JOICFP learned from the experience' of Japan, which demonstrated the importance of balancing quantity and quality.

  5. Study on system dynamics of evolutionary mix-game models

    NASA Astrophysics Data System (ADS)

    Gou, Chengling; Guo, Xiaoqian; Chen, Fang

    2008-11-01

    Mix-game model is ameliorated from an agent-based MG model, which is used to simulate the real financial market. Different from MG, there are two groups of agents in Mix-game: Group 1 plays a majority game and Group 2 plays a minority game. These two groups of agents have different bounded abilities to deal with historical information and to count their own performance. In this paper, we modify Mix-game model by assigning the evolution abilities to agents: if the winning rates of agents are smaller than a threshold, they will copy the best strategies the other agent has; and agents will repeat such evolution at certain time intervals. Through simulations this paper finds: (1) the average winning rates of agents in Group 1 and the mean volatilities increase with the increases of the thresholds of Group 1; (2) the average winning rates of both groups decrease but the mean volatilities of system increase with the increase of the thresholds of Group 2; (3) the thresholds of Group 2 have greater impact on system dynamics than the thresholds of Group 1; (4) the characteristics of system dynamics under different time intervals of strategy change are similar to each other qualitatively, but they are different quantitatively; (5) As the time interval of strategy change increases from 1 to 20, the system behaves more and more stable and the performances of agents in both groups become better also.

  6. Inertia in strategy switching transforms the strategy evolution

    NASA Astrophysics Data System (ADS)

    Zhang, Yanling; Fu, Feng; Wu, Te; Xie, Guangming; Wang, Long

    2011-12-01

    A recent experimental study [Traulsen , Proc. Natl. Acad. Sci.PNASA60027-842410.1073/pnas.0912515107 107, 2962 (2010)] shows that human strategy updating involves both direct payoff comparison and the cost of switching strategy, which is equivalent to inertia. However, it remains largely unclear how such a predisposed inertia affects 2×2 games in a well-mixed population of finite size. To address this issue, the “inertia bonus” (strategy switching cost) is added to the learner payoff in the Fermi process. We find how inertia quantitatively shapes the stationary distribution and that stochastic stability under inertia exhibits three regimes, with each covering seven regions in the plane spanned by two inertia parameters. We also obtain the extended “1/3” rule with inertia and the speed criterion with inertia; these two findings hold for a population above two. We illustrate the above results in the framework of the Prisoner's Dilemma game. As inertia varies, two intriguing stationary distributions emerge: the probability of coexistence state is maximized, or those of two full states are simultaneously peaked. Our results may provide useful insights into how the inertia of changing status quo acts on the strategy evolution and, in particular, the evolution of cooperation.

  7. Alzheimer's disease susceptibility variants in the MS4A6A gene are associated with altered levels of MS4A6A expression in blood.

    PubMed

    Proitsi, Petroula; Lee, Sang Hyuck; Lunnon, Katie; Keohane, Aoife; Powell, John; Troakes, Claire; Al-Sarraj, Safa; Furney, Simon; Soininen, Hilkka; Kłoszewska, Iwona; Mecocci, Patrizia; Tsolaki, Magda; Vellas, Bruno; Lovestone, Simon; Hodges, Angela

    2014-02-01

    An increased risk of developing Alzheimer's disease (AD) has previously been found to be associated with variants at the MS4A6A locus. We sought to identify which genes and transcripts in this region have altered expression in AD and mild cognitive impairment (MCI) and are influenced by the AD risk variant(s), as a first step to understanding the molecular basis of AD susceptibility at this locus. Common variants located within highly expressed MS4A6A transcripts were significantly associated with AD and MS4A6A expression levels in blood from MCI and AD subjects (p < 0.05, rs610932, rs7232, rs583791). More copies of the protective (minor) allele were associated with lower MS4A6A expression of each transcript (e.g., p = 0.019; rs610932-total MS4A6A). Furthermore, in heterozygous AD subjects, relative expression of the protective allele of V4-MS4A6A transcripts was lower (p < 0.008). Irrespective of genotype, MS4A6A transcripts were increased in blood from people with AD (p < 0.003), whereas lower expression of full length V1-MS4A6A (p = 0.002) and higher expression of V4-MS4A6A (p = 1.8 × 10(-4)) were observed in MCI, relative to elderly controls. The association between genotype and expression was less consistent in brain, although BA9 did have a similar genotype association with V4-MS4A6A transcripts as in blood. MS4A6A transcripts were widely expressed in tissues and cells, with the exception of V4-MS4A6A, which was not expressed in neuronal cells. Together these results suggest that high levels of MS4A6A in emerging AD pathology are detrimental. Persons with MCI may lower MS4A6A expression to minimize detrimental disease associated MS4A6A activity. However, those with the susceptibility allele appear unable to decrease expression sufficiently, which may explain their increased risk for developing AD. Inhibiting MS4A6A may therefore promote a more neuroprotective phenotype, although further work is needed to establish whether this is the case.

  8. Turbulent mix experiments and simulations

    SciTech Connect

    Dimonte, G.; Schneider, M.; Frerking, C.E.

    1995-08-01

    Hydrodynamic instabilities produce material mixing that can significantly degrade weapons performance. We investigate the Richtmyer-Meshkov (RM) and Rayleigh-Taylor (RT) instabilities in the turbulent regime in two experimental venues. RM experiments are conducted on the Nova laser with strong radiatively driven shocks (Mach > 20) in planar, two fluid targets. Interfacial perturbations are imposed with single sinusoidal modes to test linear theory and with three dimensional (3D) random modes to produce turbulent mix. RT experiments are conducted on a new facility, the Linear Electric Motor (LEM), in which macroscopic fluids are accelerated with arbitrary temporal profiles. This allows detailed diagnosis of the turbulence over a wide range of conditions. The Nova experiments study the high compression regime whereas the LEM experiments are incompressible. The results are compared to hydrodynamic simulations with the arbitrary Lagrangian-Eulerian code (CALE). The goal is to develop and test engineering models of mix.

  9. Treatment technology analysis for mixed waste containers and debris

    SciTech Connect

    Gehrke, R.J.; Brown, C.H.; Langton, C.A.; Askew, N.M.; Kan, T.; Schwinkendorf, W.E.

    1994-03-01

    A team was assembled to develop technology needs and strategies for treatment of mixed waste debris and empty containers in the Department of Energy (DOE) complex, and to determine the advantages and disadvantages of applying the Debris and Empty Container Rules to these wastes. These rules issued by the Environmental Protection Agency (EPA) apply only to the hazardous component of mixed debris. Hazardous debris that is subjected to regulations under the Atomic Energy Act because of its radioactivity (i.e., mixed debris) is also subject to the debris treatment standards. The issue of treating debris per the Resource Conservation and Recovery Act (RCRA) at the same time or in conjunction with decontamination of the radioactive contamination was also addressed. Resolution of this issue requires policy development by DOE Headquarters of de minimis concentrations for radioactivity and release of material to Subtitle D landfills or into the commercial sector. The task team recommends that, since alternate treatment technologies (for the hazardous component) are Best Demonstrated Available Technology (BDAT): (1) funding should focus on demonstration, testing, and evaluation of BDAT on mixed debris, (2) funding should also consider verification of alternative treatments for the decontamination of radioactive debris, and (3) DOE should establish criteria for the recycle/reuse or disposal of treated and decontaminated mixed debris as municipal waste.

  10. The Marketing Mix and Development of Medical Tourism in Shiraz

    PubMed Central

    Jabbari, Alireza; Rahimi Zarchi, Mohammad Kazem; Kavosi, Zahra; Shafaghat, Tahere; Keshtkaran, Ali

    2013-01-01

    Introduction: In recent years, medical tourism market has been raised as one of the income-earning and competitive industries in the world and is considered as a modern field of advanced tourism. Therefore, a great number of countries are seeking to develop this type of tourism and one of the strategies for developing this industry is using the marketing mix elements. Methods: This study was a descriptive-analytic and cross sectional one. The research community included all the public and private hospitals of Shiraz among which, 7 public and 9 private hospitals were studied. The study data were collected through a researcher-made check list whose face and content validity was confirmed by the experts. Then, the data were entered into the SPSS statistical software. According to the objectives of the study, the descriptive results were presented in frequency tables and Chi-square test was used for data analysis. In addition, P<0.05 was considered as statistically significant. Results: According to the results, both public and private hospitals of Shiraz were in the best condition regarding staff and physician mix and in the worst condition concerning promoting and facilities mixes. No significant difference was found between public and private hospitals regarding the mixes. Conclusion: From marketing mix elements view, paying more attention to media advertisements and providing more facilities can improve the status of the hospitals which, consequently, results in attracting more medical tourists and developing this industry in Shiraz. PMID:23678337

  11. Mixed Waste Treatment Project: Computer simulations of integrated flowsheets

    SciTech Connect

    Dietsche, L.J.

    1993-12-01

    The disposal of mixed waste, that is waste containing both hazardous and radioactive components, is a challenging waste management problem of particular concern to DOE sites throughout the United States. Traditional technologies used for the destruction of hazardous wastes need to be re-evaluated for their ability to handle mixed wastes, and in some cases new technologies need to be developed. The Mixed Waste Treatment Project (MWTP) was set up by DOE`s Waste Operations Program (EM30) to provide guidance on mixed waste treatment options. One of MWTP`s charters is to develop flowsheets for prototype integrated mixed waste treatment facilities which can serve as models for sites developing their own treatment strategies. Evaluation of these flowsheets is being facilitated through the use of computer modelling. The objective of the flowsheet simulations is to provide mass and energy balances, product compositions, and equipment sizing (leading to cost) information. The modelled flowsheets need to be easily modified to examine how alternative technologies and varying feed streams effect the overall integrated process. One such commercially available simulation program is ASPEN PLUS. This report contains details of the Aspen Plus program.

  12. Chaotic mixing in a planar, curved channel using periodic slip

    SciTech Connect

    Garg, P.; Picardo, J. R.; Pushpavanam, S.

    2015-03-15

    We propose a novel strategy for designing chaotic micromixers using curved channels confined between two flat planes. The location of the separatrix between the Dean vortices, induced by centrifugal forces, is dependent on the location of the maxima of axial velocity. An asymmetry in the axial velocity profile can change the location of the separatrix. This is achieved physically by introducing slip alternatingly at the top and bottom walls. This leads to streamline crossing and Lagrangian chaos. An approximate analytical solution of the velocity field is obtained using perturbation theory. This is used to find the Lagrangian trajectories of fluid particles. Poincare sections taken at periodic locations in the axial direction are used to study the extent of chaos. We study two microchannel designs, called circlet and serpentine, in which the Dean vortices in adjacent half cells are co-rotating and counter-rotating, respectively. The extent of mixing, at low Re and low slip length, is shown to be greater in the serpentine case. Wide channels are observed to have much better mixing than tall channels; an important observation not made for separatrix flows till now. Eulerian indicators are used to gauge the extent of mixing, with varying slip length, and it is shown that an optimum slip length exists which maximizes the mixing in a particular geometry. Once the parameter space of relatively high mixing is identified, detailed variance computations are carried out to identify the detailed features.

  13. Ion mixing of semiconductor superlattices

    NASA Astrophysics Data System (ADS)

    Xia, W.; Hsu, S. N.; Han, C. C.; Pappert, S. A.; Zhu, B.; Cozzolino, C.; Yu, P. K. L.; Lau, S. S.; Poker, D. B.; White, C. W.; Schwarz, S. A.

    1991-07-01

    Compositional disordering of III-V compound superlattice structures has received considerable attention recently due to its potential application for photonic devices. The conventional method to induce compositional disorder is to implant a moderate dose of impurity ions (˜ 10 15 cm -2) into the structure at room temperature, followed by a high-temperature annealing step (this process is referred to as IA here). Ion irradiation at room temperature alone does not cause any significant intermixing of layers. The subsequent high-temperature annealing step tends to restrict device processing flexibility. Ion mixing (IM) is capable of enhancing compositional disordering of layers at a rate which increases exponentially with the ion irradiation temperature. As a processing technique to planarize devices, ion mixing appears to be an attractive technology. In this work, we investigate compositional disordering in the AlGaAs/GaAs and the InGaAs/InP systems using ion mixing. We found that the ion mixing behavior of these two systems shows a thermally activated regime as well as an athermal regime, similar to that observed for metal-metal and metal-semiconductor systems. Ion mixing is observed to induce compositional disordering at significantly lower temperatures than that for the IA process. We have compared the two processes in terms of four parameters (1) irradiation temperature, (2) dose dependence, (3) annealing, and (4) electrically active ions. We found that the IM process is more efficient in utilizing the defects generated by ion irradiation to cause disordering. Both the physical mechanism of ion mixing and possible device implications will be discussed.

  14. Ion mixing of semiconductor superlattices

    NASA Astrophysics Data System (ADS)

    Xia, W.; Hsu, S. N.; Han, C. C.; Pappert, S. A.; Zhu, B.; Cozzolino, C.; Yu, P. K. L.; Lau, S. S.; Poker, D. B.; White, C. W.

    Compositional disordering of III-V compound superlattice structures has received considerable attention recently due to its potential application for photonic devices. The conventional method in induce compositional disorder is to implant a moderate dose of impurity ions (approx. 10 (exp 15)/sq cm) into the structure at room temperature, followed by a high temperature annealing step (this process is referred to as IA here). Ion irradiation at room temperature alone does not cause any significant intermixing of layers. The subsequent high temperature annealing step tends to restrict device processing flexibility. Ion mixing (IM) is capable of enhancing compositional disordering of layers at a rate which increases exponentially with the ion irradiation temperature. As a processing technique to planarize devices, ion mixing appears to be an attractive technology. Compositional disordering was studied disordering in the AlGaAs/GaAs and the InGaAs/InP systems using ion mixing. It was found that the ion mixing behavior of these two systems shows a thermally activated regime as well as an athermal regime, similar to that observed for metal-metal and metal-semiconductor systems. Ion mixing is observed to induce compositional disordering at significantly lower temperatures than that for the IA process. The two processes were compared in terms of five parameters (1) irradiation temperature, (2) dose dependence (3) annealing, and (4) electrically active ions. It was found that the IM process is more efficient in utilizing the defects generated by ion irradiation to cause disordering. Both the physical mechanism of ion mixing and possible device implications will be discussed.

  15. Further evidence for mixed emotions.

    PubMed

    Larsen, Jeff T; McGraw, A Peter

    2011-06-01

    Emotion theorists have long debated whether valence, which ranges from pleasant to unpleasant states, is an irreducible aspect of the experience of emotion or whether positivity and negativity are separable in experience. If valence is irreducible, it follows that people cannot feel happy and sad at the same time. Conversely, if positivity and negativity are separable, people may be able to experience such mixed emotions. The authors tested several alternative interpretations for prior evidence that happiness and sadness can co-occur in bittersweet situations (i.e., those containing both pleasant and unpleasant aspects). One possibility is that subjects who reported mixed emotions merely vacillated between happiness and sadness. The authors tested this hypothesis in Studies 1-3 by asking subjects to complete online continuous measures of happiness and sadness. Subjects reported more simultaneously mixed emotions during a bittersweet film clip than during a control clip. Another possibility is that subjects in earlier studies reported mixed emotions only because they were explicitly asked whether they felt happy and sad. The authors tested this hypothesis in Studies 4-6 with open-ended measures of emotion. Subjects were more likely to report mixed emotions after the bittersweet clip than the control clip. Both patterns occurred even when subjects were told that they were not expected to report mixed emotions (Studies 2 and 5) and among subjects who did not previously believe that people could simultaneously feel happy and sad (Studies 3 and 6). These results provide further evidence that positivity and negativity are separable in experience.

  16. Mixing in Magnetized Turbulent Media

    NASA Astrophysics Data System (ADS)

    Sur, Sharanya; Pan, Liubin; Scannapieco, Evan

    2014-04-01

    Turbulent motions are essential to the mixing of entrained fluids and are also capable of amplifying weak initial magnetic fields by small-scale dynamo action. Here we perform a systematic study of turbulent mixing in magnetized media, using three-dimensional magnetohydrodynamic simulations that include a scalar concentration field. We focus on how mixing depends on the magnetic Prandtl number, Pm, from 1 to 4 and the Mach number, { {M}}, from 0.3 to 2.4. For all subsonic flows, we find that the velocity power spectrum has a k -5/3 slope in the early kinematic phase, but steepens due to magnetic back reactions as the field saturates. The scalar power spectrum, on the other hand, flattens compared to k -5/3 at late times, consistent with the Obukohov-Corrsin picture of mixing as a cascade process. At higher Mach numbers, the velocity power spectrum also steepens due to the presence of shocks, and the scalar power spectrum again flattens accordingly. Scalar structures are more intermittent than velocity structures in subsonic turbulence, whereas for supersonic turbulence, velocity structures appear more intermittent than the scalars only in the kinematic phase. Independent of the Mach number of the flow, scalar structures are arranged in sheets in both the kinematic and saturated phases of the magnetic field evolution. For subsonic turbulence, scalar dissipation is hindered in the strong magnetic field regions, probably due to Lorentz forces suppressing the buildup of scalar gradients, whereas for supersonic turbulence, scalar dissipation increases monotonically with increasing magnetic field strength. At all Mach numbers, mixing is significantly slowed by the presence of dynamically important small-scale magnetic fields, implying that mixing in the interstellar medium and in galaxy clusters is less efficient than modeled in hydrodynamic simulations.

  17. Nonideal Rayleigh-Taylor mixing

    SciTech Connect

    Sharp, David Howland; Lin, Hyun K; Iwerks, Justin G; Gliman, James G

    2009-01-01

    Rayleigh-Taylor mixing is a classical hydrodynamic Instability, which occurs when a light fluid pushes against a heavy fluid. The two main sources of nonideal behavior in Rayleigh-Taylor (RT) mixing are regularizations (physical and numerical) which produce deviations from a pure Euler equation, scale Invariant formulation, and non Ideal (i.e. experimental) initial conditions. The Kolmogorov theory of turbulence predicts stirring at all length scales for the Euler fluid equations without regularization. We Interpret mathematical theories of existence and non-uniqueness in this context, and we provide numerical evidence for dependence of the RT mixing rate on nonideal regularizations, in other words indeterminacy when modeled by Euler equations. Operationally, indeterminacy shows up as non unique solutions for RT mixing, parametrized by Schmidt and Prandtl numbers, In the large Reynolds number (Euler equation) limit. Verification and validation evidence is presented for the large eddy simulation algorithm used here. Mesh convergence depends on breaking the nonuniqueness with explicit use of the laminar Schmidt and PrandtJ numbers and their turbulent counterparts, defined in terms of subgrid scale models. The dependence of the mixing rate on the Schmidt and Prandtl numbers and other physical parameters will be illustrated. We demonstrate numerically the influence of initial conditions on the mixing rate. Both the dominant short wavelength Initial conditions and long wavelength perturbations are observed to playa role. By examination of two classes of experiments, we observe the absence of a single universal explanation, with long and short wavelength initial conditions, and the various physical and numerical regularizations contributing In different proportions In these two different contexts.

  18. Mixe de Tlahuitoltepec, Oaxaca (Mixe of Tlahuitoltepec, Oaxaca).

    ERIC Educational Resources Information Center

    Mexico Coll. (Mexico City)

    This document is one of 17 volumes on indigenous Mexican languages and is the result of a project undertaken by the Archivo de Lenguas Indigenas de Mexico. This volume contains information on Mixe, an indigenous language of Mexico spoken in Tlahuitoltepec, in the state of Oaxaca. The objective of collecting such a representative sampling of the…

  19. Use and abuse of mixing models (MixSIAR)

    EPA Science Inventory

    Background/Question/MethodsCharacterizing trophic links in food webs is a fundamental ecological question. In our efforts to quantify energy flow through food webs, ecologists have increasingly used mixing models to analyze biological tracer data, often from stable isotopes. Whil...

  20. Mixed ternary heterojunction solar cell

    DOEpatents

    Chen, Wen S.; Stewart, John M.

    1992-08-25

    A thin film heterojunction solar cell and a method of making it has a p-type layer of mixed ternary I-III-VI.sub.2 semiconductor material in contact with an n-type layer of mixed binary II-VI semiconductor material. The p-type semiconductor material includes a low resistivity copper-rich region adjacent the back metal contact of the cell and a composition gradient providing a minority carrier mirror that improves the photovoltaic performance of the cell. The p-type semiconductor material preferably is CuInGaSe.sub.2 or CuIn(SSe).sub.2.

  1. Polarization mixing optical parametric oscillator.

    SciTech Connect

    Pearl, Shaul; Smith, Arlee Virgil; Arie, Ady; Blau, Pinhas; Kalmani, Gal

    2005-05-01

    We report the experimental realization of a new type of optical parametric oscillator in which oscillation is achieved by polarization rotation in a linear retarder, followed by nonlinear polarization mixing. The mixing is performed by a type II degenerate parametric downconversion in a periodically poled KTP crystal pumped by a 1064 nm pulsed Nd:YAG pump. A single, linearly polarized beam, precisely at the degenerate wavelength is generated. The output spectrum has a narrow linewidth (below the instrumentation bandwidth of 1 nm) and is highly stable with respect to variations in the crystal temperature.

  2. Bs Mixing at the Tevatron

    SciTech Connect

    Gomez-Ceballos, Guillelmo; /Cantabria Inst. of Phys.

    2006-04-01

    The Tevatron collider at Fermilab provides a very rich environment for the study of B{sub s} mesons. B{sub s} Mixing is the most important analysis within the B Physics program of both experiments. In this paper they summarize the most recent results on this topic from both D0 and CDF experiments. There were very important updates in both experiments after his last talk, hence the organizers warmly recommended me to include the latest available results on B{sub s} mixing, instead of what he presents there.

  3. A Mixed Methods Content Analysis of the Research Literature in Science Education

    NASA Astrophysics Data System (ADS)

    Schram, Asta B.

    2014-10-01

    In recent years, more and more researchers in science education have been turning to the practice of combining qualitative and quantitative methods in the same study. This approach of using mixed methods creates possibilities to study the various issues that science educators encounter in more depth. In this content analysis, I evaluated 18 studies from science education journals as they relate to the definition, design, and overall practice of using mixed methods. I scrutinized a purposeful sample, derived from 3 journals (the International Journal of Science Education, the Journal of Research in Science Teaching, and the Research in Science Education) in terms of the type of data collected, timing, priority, design, the mixing of the 2 data strands in the studies, and the justifications authors provide for using mixed methods. Furthermore, the articles were evaluated in terms of how well they met contemporary definitions for mixed methods research. The studies varied considerably in the use and understanding of mixed methods. A systematic evaluation of the employment of mixed methods methodology was used to identify the studies that best reflected contemporary definitions. A comparison to earlier content analyses of mixed methods research indicates that researchers' knowledge of mixed methods methodology may be increasing. The use of this strategy in science education research calls, however, for an improved methodology, especially concerning the practice of mixing. Suggestions are given on how to best use this approach.

  4. On the quantification of mixing in microfluidics.

    PubMed

    Hashmi, Ali; Xu, Jie

    2014-10-01

    Methods for quantifying mixing in microfluidics have varied largely in the past, and various indices have been employed to represent the extent of mixing. Mixing between two or more colored liquids is usually quantified using simple mathematical functions operated over a sequence of images. The function, usually termed mixing indices, involves a measure of standard deviation. Here, we first review some mixing indices and then experimentally verify the index most representative of a mixing event. It is observed that the relative mixing index is not affected by the lighting conditions, unlike other known mixing indices. Based on this finding, the use of a relative mixing index is advocated for further use in the lab-on-a-chip community for quantifying mixing events.

  5. Benefits, Challenges, and Dynamism of Positionalities Associated with Mixed Methods Research in Developing Countries: Evidence from Ghana

    ERIC Educational Resources Information Center

    Teye, Joseph Kofi

    2012-01-01

    Although mixed methods designs have gained visibility in recent years, most of the publications on this methodological strategy have been written by scholars in the developed world. Consequently, the practical challenges associated with mixed methods research in developing countries have not been adequately discussed in the literature. Relying on…

  6. Colour Mixing Based on Daylight

    ERIC Educational Resources Information Center

    Meyn, Jan-Peter

    2008-01-01

    Colour science is based on the sensation of monochromatic light. In contrast to that, surface colours are caused by reflection of wide sections of the daylight spectrum. Non-spectral colours like magenta and purple appear homologous to colours with spectral hue, if the approach of mixing monochromatic light is abandoned. It is shown that a large…

  7. Advances in compressible turbulent mixing

    SciTech Connect

    Dannevik, W.P.; Buckingham, A.C.; Leith, C.E.

    1992-01-01

    This volume includes some recent additions to original material prepared for the Princeton International Workshop on the Physics of Compressible Turbulent Mixing, held in 1988. Workshop participants were asked to emphasize the physics of the compressible mixing process rather than measurement techniques or computational methods. Actual experimental results and their meaning were given precedence over discussions of new diagnostic developments. Theoretical interpretations and understanding were stressed rather than the exposition of new analytical model developments or advances in numerical procedures. By design, compressibility influences on turbulent mixing were discussed--almost exclusively--from the perspective of supersonic flow field studies. The papers are arranged in three topical categories: Foundations, Vortical Domination, and Strongly Coupled Compressibility. The Foundations category is a collection of seminal studies that connect current study in compressible turbulent mixing with compressible, high-speed turbulent flow research that almost vanished about two decades ago. A number of contributions are included on flow instability initiation, evolution, and transition between the states of unstable flow onset through those descriptive of fully developed turbulence. The Vortical Domination category includes theoretical and experimental studies of coherent structures, vortex pairing, vortex-dynamics-influenced pressure focusing. In the Strongly Coupled Compressibility category the organizers included the high-speed turbulent flow investigations in which the interaction of shock waves could be considered an important source for production of new turbulence or for the enhancement of pre-existing turbulence. Individual papers are processed separately.

  8. Mixing and transport. [Water pollution

    SciTech Connect

    Roberts, P.J.W.

    1982-06-01

    The mixing and transport of water pollution is the subject of this literature review with 110 references. The environmental transport of pollutants is examined in streams, rivers, reservoirs, ponds, estuaries, salt marshes and coastal waters. The dynamics of fluid flow, and the physical properties of jets, plumes, and stratified fluids are discussed. (KRM)

  9. Turbulent Mixing Chemistry in Disks

    NASA Astrophysics Data System (ADS)

    Semenov, D.; Wiebe, D.

    2006-11-01

    A gas-grain chemical model with surface reaction and 1D/2D turbulent mixing is available for protoplanetary disks and molecular clouds. Current version is based on the updated UMIST'95 database with gas-grain interactions (accretion, desorption, photoevaporation, etc.) and modified rate equation approach to surface chemistry (see also abstract for the static chemistry code).

  10. Racially Mixed People in America.

    ERIC Educational Resources Information Center

    Root, Maria P. P., Ed.

    This book offers a comprehensive look at the social and psychological adjustment of multiracial people, models for identity development, contemporary immigration and marriage patterns, and methodological issues involved in conducting research with mixed-race people, all in the context of America's multiracial past and present. The following 26…

  11. Bayesian stable isotope mixing models

    EPA Science Inventory

    In this paper we review recent advances in Stable Isotope Mixing Models (SIMMs) and place them into an over-arching Bayesian statistical framework which allows for several useful extensions. SIMMs are used to quantify the proportional contributions of various sources to a mixtur...

  12. Simple rheology of mixed proteins

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Mixing different proteins to form strong gel networks for food applications may create synergistic increases in viscoelasticity that cannot be achieved with a single protein. In this study, small amplitude oscillatory shear analyses were used to investigate the rheology of calcium caseinate (CC), e...

  13. Mixing It Up with Acrylics.

    ERIC Educational Resources Information Center

    Laird, Shirley

    1999-01-01

    Presents an art activity for fifth-grade students in which they learn about basic shapes and what happens when shapes overlap, draw seven overlapping geometric shapes, review the use of acrylic paint and mixing colors, and finally paint with primary colors. (CMK)

  14. Towards understanding turbulent scalar mixing

    NASA Technical Reports Server (NTRS)

    Girimaji, Sharath S.

    1992-01-01

    In an effort towards understanding turbulent scalar mixing, we study the effect of molecular mixing, first in isolation and then by accounting for the effects of the velocity field. The chief motivation for this approach stems from the strong resemblance of the scalar probability density function (PDF) obtained from the scalar field evolving from the heat conduction equation that arises in a turbulent velocity field. However, the evolution of the scalar dissipation is different for the two cases. We attempt to account for these differences, which are due to the velocity field, using a Lagrangian frame analysis. After establishing the usefulness of this approach, we use the heat-conduction simulations (HCS), in lieu of the more expensive direct numerical simulations (DNS), to study many of the less understood aspects of turbulent mixing. Comparison between the HCS data and available models are made whenever possible. It is established that the beta PDF characterizes the evolution of the scalar PDF during mixing from all types of non-premixed initial conditions.

  15. Reductant injection and mixing system

    SciTech Connect

    Reeves, Matt; Henry, Cary A.; Ruth, Michael J.

    2016-02-16

    A gaseous reductant injection and mixing system is described herein. The system includes an injector for injecting a gaseous reductant into an exhaust gas stream, and a mixer attached to a surface of the injector. The injector includes a plurality of apertures through which the gaseous reductant is injected into an exhaust gas stream. The mixer includes a plurality of fluid deflecting elements.

  16. Bilarge neutrino mixing and the Cabibbo angle

    NASA Astrophysics Data System (ADS)

    Boucenna, S. M.; Morisi, S.; Tórtola, M.; Valle, J. W. F.

    2012-09-01

    Recent measurements of the neutrino mixing angles cast doubt on the validity of the so-far popular tribimaximal mixing Ansatz. We propose a parametrization for the neutrino mixing matrix where the reactor angle seeds the large solar and atmospheric mixing angles, equal to each other in first approximation. We suggest such a bilarge mixing pattern as a model-building standard, realized when the leading order value of θ13 equals the Cabibbo angle λC.

  17. A mixed relaxed clock model

    PubMed Central

    2016-01-01

    Over recent years, several alternative relaxed clock models have been proposed in the context of Bayesian dating. These models fall in two distinct categories: uncorrelated and autocorrelated across branches. The choice between these two classes of relaxed clocks is still an open question. More fundamentally, the true process of rate variation may have both long-term trends and short-term fluctuations, suggesting that more sophisticated clock models unfolding over multiple time scales should ultimately be developed. Here, a mixed relaxed clock model is introduced, which can be mechanistically interpreted as a rate variation process undergoing short-term fluctuations on the top of Brownian long-term trends. Statistically, this mixed clock represents an alternative solution to the problem of choosing between autocorrelated and uncorrelated relaxed clocks, by proposing instead to combine their respective merits. Fitting this model on a dataset of 105 placental mammals, using both node-dating and tip-dating approaches, suggests that the two pure clocks, Brownian and white noise, are rejected in favour of a mixed model with approximately equal contributions for its uncorrelated and autocorrelated components. The tip-dating analysis is particularly sensitive to the choice of the relaxed clock model. In this context, the classical pure Brownian relaxed clock appears to be overly rigid, leading to biases in divergence time estimation. By contrast, the use of a mixed clock leads to more recent and more reasonable estimates for the crown ages of placental orders and superorders. Altogether, the mixed clock introduced here represents a first step towards empirically more adequate models of the patterns of rate variation across phylogenetic trees. This article is part of the themed issue ‘Dating species divergences using rocks and clocks’. PMID:27325829

  18. A mixed relaxed clock model.

    PubMed

    Lartillot, Nicolas; Phillips, Matthew J; Ronquist, Fredrik

    2016-07-19

    Over recent years, several alternative relaxed clock models have been proposed in the context of Bayesian dating. These models fall in two distinct categories: uncorrelated and autocorrelated across branches. The choice between these two classes of relaxed clocks is still an open question. More fundamentally, the true process of rate variation may have both long-term trends and short-term fluctuations, suggesting that more sophisticated clock models unfolding over multiple time scales should ultimately be developed. Here, a mixed relaxed clock model is introduced, which can be mechanistically interpreted as a rate variation process undergoing short-term fluctuations on the top of Brownian long-term trends. Statistically, this mixed clock represents an alternative solution to the problem of choosing between autocorrelated and uncorrelated relaxed clocks, by proposing instead to combine their respective merits. Fitting this model on a dataset of 105 placental mammals, using both node-dating and tip-dating approaches, suggests that the two pure clocks, Brownian and white noise, are rejected in favour of a mixed model with approximately equal contributions for its uncorrelated and autocorrelated components. The tip-dating analysis is particularly sensitive to the choice of the relaxed clock model. In this context, the classical pure Brownian relaxed clock appears to be overly rigid, leading to biases in divergence time estimation. By contrast, the use of a mixed clock leads to more recent and more reasonable estimates for the crown ages of placental orders and superorders. Altogether, the mixed clock introduced here represents a first step towards empirically more adequate models of the patterns of rate variation across phylogenetic trees.This article is part of the themed issue 'Dating species divergences using rocks and clocks'.

  19. New marketing mix stresses service.

    PubMed

    Collier, D A

    1991-01-01

    The seven Ps of service management include some nontraditional ingredients to help formulate marketing strategy. Two examples illustrate how competitive advantage can be won or lost based on applying or ignoring the seven Ps.

  20. Analysis of natural gas supply strategies at Fort Drum

    SciTech Connect

    Stucky, D.J.; Shankle, S.A.; Anderson, D.M.

    1992-07-01

    This analysis investigates strategies for Fort Drum to acquire a reliable natural gas supply while reducing its gas supply costs. The purpose of this study is to recommend an optimal supply mix based on the life-cycle costs of each strategy analyzed. In particular, this study is intended to provide initial guidance as to whether or not the building and operating of a propane-air mixing station is a feasible alternative to the current gas acquisition strategy. The analysis proceeded by defining the components of supply (gas purchase, gas transport, supplemental fuel supply); identifying alternative options for each supply component; constructing gas supply strategies from different combinations of the options available for each supply component and calculating the life-cycle costs of each supply strategy under a set of different scenarios reflecting the uncertainty of future events.

  1. 40 CFR 52.1680 - Control strategy: Monitoring and reporting.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 4 2010-07-01 2010-07-01 false Control strategy: Monitoring and reporting. 52.1680 Section 52.1680 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Control strategy: Monitoring and reporting. (a) Section 227.6 (a) and (f) are disapproved because they...

  2. The role of phosphorylation in activation of the alpha 6A beta 1 laminin receptor.

    PubMed

    Hogervorst, F; Kuikman, I; Noteboom, E; Sonnenberg, A

    1993-09-05

    The phorbol ester phorbol 12-myristate 13-acetate (PMA) induces phosphorylation of serine residues in the cytoplasmic domain of the alpha 6A integrin subunit, as well as activation of the alpha 6A beta 1 laminin receptor. We examined whether phosphorylation correlates with the induction of high affinity binding of laminin by the alpha 6A beta 1 receptor. Two potential phosphorylation sites for protein kinase C, serine 1041 and serine 1048, are present in the cytoplasmic domain of the alpha 6A subunit. We introduced point mutations into the alpha 6A cDNA, replacing either one or both of the serine residues with alanine. Wild-type and mutant alpha 6A cDNAs were transfected into K562 cells. All alpha 6A subunit mutants were expressed at levels similar to those of wild-type alpha 6A and formed heterodimers with endogenous beta 1. Analysis of the phosphorylation state of wild-type and mutant alpha 6A subunits in resting K562 cells and after treatment with PMA showed that serine 1041, but not serine 1048, is the target residue of PMA-induced phosphorylation. Cells expressing alpha 6A mutant subunits or wild-type alpha 6A transfectants all bound laminin in the presence, but not in the absence of PMA; however, the extent of binding differed. Cells transfected with alpha 6A containing the serine to alanine mutation showed a 2-3-fold higher binding to laminin than cells transfected with alpha 6A containing serine 1041. The results indicate that phosphorylation of the alpha 6A cytoplasmic domain is not required for the induction of high affinity of the alpha 6A beta 1 receptor by PMA, and suggest that, in contrast, it may reduce the affinity of this integrin for ligand.

  3. Mixed methods research in mental health nursing.

    PubMed

    Kettles, A M; Creswell, J W; Zhang, W

    2011-08-01

    Mixed methods research is becoming more widely used in order to answer research questions and to investigate research problems in mental health and psychiatric nursing. However, two separate literature searches, one in Scotland and one in the USA, revealed that few mental health nursing studies identified mixed methods research in their titles. Many studies used the term 'embedded' but few studies identified in the literature were mixed methods embedded studies. The history, philosophical underpinnings, definition, types of mixed methods research and associated pragmatism are discussed, as well as the need for mixed methods research. Examples of mental health nursing mixed methods research are used to illustrate the different types of mixed methods: convergent parallel, embedded, explanatory and exploratory in their sequential and concurrent combinations. Implementing mixed methods research is also discussed briefly and the problem of identifying mixed methods research in mental and psychiatric nursing are discussed with some possible solutions to the problem proposed.

  4. HETEROGENEOUS REBURNING BY MIXED FUELS

    SciTech Connect

    Wei-Yin Chen; Benson B. Gathitu

    2005-01-14

    Recent studies of heterogeneous reburning, i.e., reburning involving a coal-derived char, have elucidated its variables, kinetics and mechanisms that are valuable to the development of a highly efficient reburning process. Young lignite chars contain catalysts that not only reduce NO, but they also reduce HCN that is an important intermediate that recycles to NO in the burnout zone. Gaseous CO scavenges the surface oxides that are formed during NO reduction, regenerating the active sites on the char surface. Based on this mechanistic information, cost-effective mixed fuels containing these multiple features has been designed and tested in a simulated reburning apparatus. Remarkably high reduction of NO and HCN has been observed and it is anticipated that mixed fuel will remove 85% of NO in a three-stage reburning process.

  5. Topological mixing with ghost rods

    NASA Astrophysics Data System (ADS)

    Gouillart, Emmanuelle; Thiffeault, Jean-Luc; Finn, Matthew D.

    2006-03-01

    Topological chaos relies on the periodic motion of obstacles in a two-dimensional flow in order to form nontrivial braids. This motion generates exponential stretching of material lines, and hence efficient mixing. Boyland, Aref, and Stremler [J. Fluid Mech. 403, 277 (2000)] have studied a specific periodic motion of rods that exhibits topological chaos in a viscous fluid. We show that it is possible to extend their work to cases where the motion of the stirring rods is topologically trivial by considering the dynamics of special periodic points that we call “ghost rods”, because they play a similar role to stirring rods. The ghost rods framework provides a new technique for quantifying chaos and gives insight into the mechanisms that produce chaos and mixing. Numerical simulations for Stokes flow support our results.

  6. Topological mixing with ghost rods.

    PubMed

    Gouillart, Emmanuelle; Thiffeault, Jean-Luc; Finn, Matthew D

    2006-03-01

    Topological chaos relies on the periodic motion of obstacles in a two-dimensional flow in order to form nontrivial braids. This motion generates exponential stretching of material lines, and hence efficient mixing. Boyland, Aref, and Stremler [J. Fluid Mech. 403, 277 (2000)] have studied a specific periodic motion of rods that exhibits topological chaos in a viscous fluid. We show that it is possible to extend their work to cases where the motion of the stirring rods is topologically trivial by considering the dynamics of special periodic points that we call "ghost rods", because they play a similar role to stirring rods. The ghost rods framework provides a new technique for quantifying chaos and gives insight into the mechanisms that produce chaos and mixing. Numerical simulations for Stokes flow support our results.

  7. Pediatric Mixed Connective Tissue Disease.

    PubMed

    Berard, Roberta A; Laxer, Ronald M

    2016-05-01

    Pediatric-onset mixed connective tissue disease is among the rare disease entities in pediatric rheumatology and includes features of arthritis, polymyositis/dermatomyositis, systemic lupus erythematosus, and systemic sclerosis. Accurate recognition and diagnosis of the disease is paramount to prevent long-term morbidity. Advances in the genetic and immunologic understanding of the factors involved in the etiopathogenesis provide an opportunity for improvements in prognostication and targeted therapy. The development of a multinational cohort of patients with mixed connective tissue disease would be invaluable to provide more updated data regarding the clinical presentation, to develop a standardized treatment approach, disease activity and outcome tools, and to provide data on long-term outcomes and comorbidities.

  8. Kinetic mixing at strong coupling

    NASA Astrophysics Data System (ADS)

    Del Zotto, Michele; Heckman, Jonathan J.; Kumar, Piyush; Malekian, Arada; Wecht, Brian

    2017-01-01

    A common feature of many string-motivated particle physics models is additional strongly coupled U (1 )'s. In such sectors, electric and magnetic states have comparable mass, and integrating out modes also charged under U (1 ) hypercharge generically yields C P preserving electric kinetic mixing and C P violating magnetic kinetic mixing terms. Even though these extra sectors are strongly coupled, we show that in the limit where the extra sector has approximate N =2 supersymmetry, we can use formal methods from Seiberg-Witten theory to compute these couplings. We also calculate various quantities of phenomenological interest such as the cross section for scattering between visible sector states and heavy extra sector states as well as the effects of supersymmetry breaking induced from coupling to the minimal supersymmetric Standard Model.

  9. Heterogeneous Reburning By Mixed Fuels

    SciTech Connect

    Anderson Hall

    2009-03-31

    Recent studies of heterogeneous reburning, i.e., reburning involving a coal-derived char, have elucidated its variables, kinetics and mechanisms that are valuable to the development of a highly efficient reburning process. Young lignite chars contain catalysts that not only reduce NO, but they also reduce HCN that is an important intermediate that recycles to NO in the burnout zone. Gaseous CO scavenges the surface oxides that are formed during NO reduction, regenerating the active sites on the char surface. Based on this mechanistic information, cost-effective mixed fuels containing these multiple features has been designed and tested in a simulated reburning apparatus. Remarkably high reduction of NO and HCN has been observed and it is anticipated that mixed fuel will remove 85% of NO in a three-stage reburning process.

  10. What is the optimum social marketing mix to market energy conservation behaviour: an empirical study.

    PubMed

    Sheau-Ting, Low; Mohammed, Abdul Hakim; Weng-Wai, Choong

    2013-12-15

    This study attempts to identify the optimum social marketing mix for marketing energy conservation behaviour to students in Malaysian universities. A total of 2000 students from 5 major Malaysian universities were invited to provide their preferred social marketing mix. A choice-based conjoint analysis identified a mix of five social marketing attributes to promote energy conservation behaviour; the mix is comprised of the attributes of Product, Price, Place, Promotion, and Post-purchase Maintenance. Each attribute of the mix is associated with a list of strategies. The Product and Post-purchase Maintenance attributes were identified by students as the highest priority attributes in the social marketing mix for energy conservation behaviour marketing, with shares of 27.12% and 27.02%, respectively. The least preferred attribute in the mix is Promotion, with a share of 11.59%. This study proposes an optimal social marketing mix to university management when making decisions about marketing energy conservation behaviour to students, who are the primary energy consumers in the campus. Additionally, this study will assist university management to efficiently allocate scarce resources in fulfilling its social responsibility and to overcome marketing shortcomings by selecting the right marketing mix.

  11. Reactive control processes contributing to residual switch cost and mixing cost across the adult lifespan.

    PubMed

    Whitson, Lisa R; Karayanidis, Frini; Fulham, Ross; Provost, Alexander; Michie, Patricia T; Heathcote, Andrew; Hsieh, Shulan

    2014-01-01

    In task-switching paradigms, performance is better when repeating the same task than when alternating between tasks (switch cost) and when repeating a task alone rather than intermixed with another task (mixing cost). These costs remain even after extensive practice and when task cues enable advanced preparation (residual costs). Moreover, residual reaction time mixing cost has been consistently shown to increase with age. Residual switch and mixing costs modulate the amplitude of the stimulus-locked P3b. This mixing effect is disproportionately larger in older adults who also prepare more for and respond more cautiously on these "mixed" repeat trials (Karayanidis et al., 2011). In this paper, we analyze stimulus-locked and response-locked P3 and lateralized readiness potentials to identify whether residual switch and mixing cost arise from the need to control interference at the level of stimulus processing or response processing. Residual mixing cost was associated with control of stimulus-level interference, whereas residual switch cost was also associated with a delay in response selection. In older adults, the disproportionate increase in mixing cost was associated with greater interference at the level of decision-response mapping and response programming for repeat trials in mixed-task blocks. These findings suggest that older adults strategically recruit greater proactive and reactive control to overcome increased susceptibility to post-stimulus interference. This interpretation is consistent with recruitment of compensatory strategies to compensate for reduced repetition benefit rather than an overall decline on cognitive flexibility.

  12. Do quantum strategies always win?

    NASA Astrophysics Data System (ADS)

    Anand, Namit; Benjamin, Colin

    2015-11-01

    In a seminal paper, Meyer (Phys Rev Lett 82:1052, 1999) described the advantages of quantum game theory by looking at the classical penny flip game. A player using a quantum strategy can win against a classical player almost 100 % of the time. Here we make a slight modification to the quantum game, with the two players sharing an entangled state to begin with. We then analyze two different scenarios: First in which quantum player makes unitary transformations to his qubit, while the classical player uses a pure strategy of either flipping or not flipping the state of his qubit. In this case, the quantum player always wins against the classical player. In the second scenario, we have the quantum player making similar unitary transformations, while the classical player makes use of a mixed strategy wherein he either flips or not with some probability " p." We show that in the second scenario, 100 % win record of a quantum player is drastically reduced and for a particular probability " p" the classical player can even win against the quantum player. This is of possible relevance to the field of quantum computation as we show that in this quantum game of preserving versus destroying entanglement a particular classical algorithm can beat the quantum algorithm.

  13. Lidar for Lateral Mixing (LATMIX)

    DTIC Science & Technology

    2013-09-30

    km, i.e., the “ submesoscale ”. We aim to understand the underlying mechanisms and forcing, as well as the temporal, spatial, and scale variability of...the overall objectives of the Lateral Mixing DRI to try to determine the extent to which submesoscale stirring is driven by a cascade of energy down...technical goal of our work is to develop the use of airborne LIDAR surveys of evolving dye experiments as a tool for studying submesoscale lateral dispersion

  14. Mixed real/complex factorization

    SciTech Connect

    Lima, L.T.G. . Dept. of Electrical Engineering); Martines, N.; Pinto, H.J.C.P. . Centro de Pesquisas de Energia Electrica)

    1993-02-01

    This paper describes a mixed real/complex sparse matrix factorization and solution scheme applied to a large matrix problem. Large system eigenanalysis and frequency domain methods will directly benefit from the proposed scheme, which can reduce both memory and CPU time requirements when compared to conventional complex-only solutions. The application in hand is the small signal electromechanical stability analysis of large power systems. The savings obtained are significant considering the CPU intensive nature of these matrix problems.

  15. Mixing in the solar tachocline

    NASA Astrophysics Data System (ADS)

    Brun, Allan Sacha

    We conduct numerical simulations of updated solar models including a physical treatment of the tachocline (Spiegel & Zahn 1992), the rotational transition layer localized at the base of the solar convection zone. We first describe what is the current understanding of this thin shear layer. We then show that we improve substantially the agreement between the models and the observed Sun by taking into account the macroscopic mixing occurring within this region.

  16. Coastal and Near Surface Mixing

    DTIC Science & Technology

    2016-06-07

    The challenge is to measure the mixing directly without relying on models and assumptions about the nature of turbulence. Sound is backscattered...turbulence vary considerably. The towed vehicle (Fig. 1) carries high-resolution velocity and temperature sensors (shear probes and thermistors), current...meters, a vertical array of three pairs of salinity and temperature sensors, and motion sensors. These sensors provide a measure of the density

  17. Localized ultrahigh frequency acoustic fields induced micro-vortices for submilliseconds microfluidic mixing

    NASA Astrophysics Data System (ADS)

    Cui, Weiwei; Zhang, Hao; Zhang, Hongxiang; Yang, Yang; He, Meihang; Qu, Hemi; Pang, Wei; Zhang, Daihua; Duan, Xuexin

    2016-12-01

    We present an acoustic microfluidic mixing approach via acousto-mechanically induced micro-vortices sustained by localized ultrahigh frequency (UHF) acoustic fields. A micro-fabricated solid-mounted thin-film piezoelectric resonator (SMR) with a frequency of 1.54 GHz has been integrated into microfluidic systems. Experimental and simulation results show that UHF-SMR triggers strong acoustic field gradients to produce efficient and highly localized acoustic streaming vortices, providing a powerful source for microfluidic mixing. Homogeneous mixing with 87% mixing efficiency at a Peclet number of 35520 within 1 ms has been achieved. The proposed strategy shows a great potential for microfluidic mixing and enhanced molecule transportation in minimized analytical systems.

  18. Study of Forebody Injection and Mixing with Application to Hypervelocity Airbreathing Propulsion

    NASA Technical Reports Server (NTRS)

    Axdahl, Erik; Kumar, Ajay; Wilhite, Alan

    2012-01-01

    The use of premixed, shock-induced combustion in the context of a hypervelocity, airbreathing vehicle requires effective injection and mixing of hydrogen fuel and air on the vehicle forebody. Three dimensional computational simulations of fuel injection and mixing from flush-wall and modified ramp and strut injectors are reported in this study. A well-established code, VULCAN, is used to conduct nonreacting, viscous, turbulent simulations on a flat plate at conditions relevant to a Mach 12 flight vehicle forebody. In comparing results of various fuel injection strategies, it is found that strut injection provides the greatest balance of performance between mixing efficiency and stream thrust potential.

  19. Mixed Alcohol Synthesis Catalyst Screening

    SciTech Connect

    Gerber, Mark A.; White, James F.; Stevens, Don J.

    2007-09-03

    National Renewable Energy Laboratory (NREL) and Pacific Northwest National Laboratory (PNNL) are conducting research to investigate the feasibility of producing mixed alcohols from biomass-derived synthesis gas (syngas). PNNL is tasked with obtaining commercially available or preparing promising mixed-alcohol catalysts and screening them in a laboratory-scale reactor system. Commercially available catalysts and the most promising experimental catalysts are provided to NREL for testing using a slipstream from a pilot-scale biomass gasifier. From the standpoint of producing C2+ alcohols as the major product, it appears that the rhodium catalyst is the best choice in terms of both selectivity and space-time yield (STY). However, unless the rhodium catalyst can be improved to provide minimally acceptable STYs for commercial operation, mixed alcohol synthesis will involve significant production of other liquid coproducts. The modified Fischer-Tropsch catalyst shows the most promise for providing both an acceptable selectivity to C2+ alcohols and total liquid STY. However, further optimization of the Fischer-Tropsch catalysts to improve selectivity to higher alcohols is highly desired. Selection of a preferred catalyst will likely entail a decision on the preferred coproduct slate. No other catalysts tested appear amenable to the significant improvements needed for acceptable STYs.

  20. Assessing mixed waste treatment technologies

    SciTech Connect

    Berry, J.B.; Bloom, G.A.; Hart, P.W.

    1994-06-01

    The US Department of Energy (DOE) is responsible for the management and treatment of its mixed low-level wastes (MLLW). As discussed earlier in this conference MLLW are regulated under both the Resource Conservation and Recovery Act and various DOE orders. During the next 5 years, DOE will manage over 1,200,000 m{sup 3} of MLLW and mixed transuranic (MTRU) waste at 50 sites in 22 states (see Table 1). The difference between MLLW and MTRU waste is in the concentration of elements that have a higher atomic weight than uranium. Nearly all of this waste will be located at 13 sites. More than 1400 individual mixed waste streams exist with different chemical and physical matrices containing a wide range of both hazardous and radioactive contaminants. Their containment and packaging vary widely (e.g., drums, bins, boxes, and buried waste). This heterogeneity in both packaging and waste stream constituents makes characterization difficult, which results in costly sampling and analytical procedures and increased risk to workers.

  1. Ion mixing and phase diagrams

    NASA Astrophysics Data System (ADS)

    Lau, S. S.; Liu, B. X.; Nicolet, M.-A.

    1983-05-01

    Interactions induced by ion irradiation are generally considered to be non-equilibrium processes, whereas phase diagrams are determined by phase equilibria. These two entities are seemingly unrelated. However, if one assumes that quasi-equilibrium conditions prevail after the prompt events, subsequent reactions are driven toward equilibrium by thermodynamical forces. Under this assumption, ion-induced reactions are related to equilibrium and therefore to phase diagrams. This relationship can be seen in the similarity that exists in thin films between reactions induced by ion irradiation and reactions induced by thermal annealing. In the latter case, phase diagrams have been used to predict the phase sequence of stable compound formation, notably so in cases of silicide formation. Ion-induced mixing not only can lead to stable compound formation, but also to metastable alloy formation. In some metal-metal systems, terminal solubilities can be greatly extended by ion mixing. In other cases, where the two constituents of the system have different crystal structures, extension of terminal solubility from both sides of the phase diagram eventually becomes structurally incompatible and a glassy (amorphous) mixture can form. The composition range where this bifurcation is likely to occur is in the two-phase regions of the phase diagram. These concepts are potentially useful guides in selecting metal pairs that from metallic glasses by ion mixing. In this report, phenomenological correlation between stable (and metastable) phase formation and phase diagram is discussed in terms of recent experimental data.

  2. Antibiotic Cycling and Antibiotic Mixing: Which One Best Mitigates Antibiotic Resistance?

    PubMed

    Beardmore, Robert Eric; Peña-Miller, Rafael; Gori, Fabio; Iredell, Jonathan

    2017-04-01

    Can we exploit our burgeoning understanding of molecular evolution to slow the progress of drug resistance? One role of an infection clinician is exactly that: to foresee trajectories to resistance during antibiotic treatment and to hinder that evolutionary course. But can this be done at a hospital-wide scale? Clinicians and theoreticians tried to when they proposed two conflicting behavioral strategies that are expected to curb resistance evolution in the clinic, these are known as "antibiotic cycling" and "antibiotic mixing." However, the accumulated data from clinical trials, now approaching 4 million patient days of treatment, is too variable for cycling or mixing to be deemed successful. The former implements the restriction and prioritization of different antibiotics at different times in hospitals in a manner said to "cycle" between them. In antibiotic mixing, appropriate antibiotics are allocated to patients but randomly. Mixing results in no correlation, in time or across patients, in the drugs used for treatment which is why theorists saw this as an optimal behavioral strategy. So while cycling and mixing were proposed as ways of controlling evolution, we show there is good reason why clinical datasets cannot choose between them: by re-examining the theoretical literature we show prior support for the theoretical optimality of mixing was misplaced. Our analysis is consistent with a pattern emerging in data: neither cycling or mixing is a priori better than the other at mitigating selection for antibiotic resistance in the clinic.

  3. Las Matematicas: Lenguaje Universal. Grados Intermedios, Nivel 6a: Suma de Fracciones (Mathematics: A Universal Language. Intermediate Grades, Level 6a: Addition of Fractions).

    ERIC Educational Resources Information Center

    Dissemination and Assessment Center for Bilingual Education, Austin, TX.

    This is one of a series of student booklets designed for use in a bilingual mathematics program in grades 6-8. The general format is to present each page in both Spanish and English. The mathematical topics in this booklet include addition of fractions and mixed numbers. (MK)

  4. Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans.

    PubMed

    Dong, C; Wong, M-L; Licinio, J

    2009-12-01

    We studied seven genes that reflect events relevant to antidepressant action at four sequential levels: (1) entry into the brain, (2) binding to monoaminergic transporters, and (3) distal effects at the transcription level, resulting in (4) changes in neurotrophin and neuropeptide receptors. Those genes are ATP-binding cassette subfamily B member 1 (ABCB1), the noradrenaline, dopamine, and serotonin transporters (SLC6A2, SLC6A3 and SLC6A4), cyclic AMP-responsive element binding protein 1 (CREB1), corticotropin-releasing hormone receptor 1 (CRHR1) and neurotrophic tyrosine kinase type 2 receptor (NTRK2). Sequence variability for those genes was obtained in exonic and flanking regions. A total of 56 280 000 bp across were sequenced in 536 unrelated Mexican Americans from Los Angeles (264 controls and 272 major depressive disorder (MDD)). We detected in those individuals 419 single nucleotide polymorphisms (SNPs); the nucleotide diversity was 0.00054 + or - 0.0001. Of those, a total of 204 novel SNPs were identified, corresponding to 49% of all previously reported SNPs in those genes: 72 were in untranslated regions, 19 were in coding sequences of which 7 were non-synonymous, 86 were intronic and 27 were in upstream/downstream regions. Several SNPs or haplotypes in ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1 and NTRK2 were associated with MDD, and in ABCB1, SLC6A2 and NTRK2 with antidepressant response. After controlling for age, gender and baseline 21-item Hamilton Depression Rating Scale (HAM-D21) score, as well as correcting for multiple testing, the relative reduction of HAM-D21 score remained significantly associated with two NTRK2-coding SNPs (rs2289657 and rs56142442) and the haplotype CAG at rs2289658 (splice site), rs2289657 and rs2289656. Further studies in larger independent samples will be needed to confirm these associations. Our data indicate that extensive assessment of sequence variability may contribute to increase understanding of disease susceptibility and

  5. Optimal mixing and optimal stirring for fixed energy, fixed power, or fixed palenstrophy flows

    NASA Astrophysics Data System (ADS)

    Lunasin, Evelyn; Lin, Zhi; Novikov, Alexei; Mazzucato, Anna; Doering, Charles R.

    2012-11-01

    We consider passive scalar mixing by a prescribed divergence-free velocity vector field in a periodic box and address the following question: Starting from a given initial inhomogeneous distribution of passive tracers, and given a certain energy budget, power budget, or finite palenstrophy budget, what incompressible flow field best mixes the scalar quantity? We focus on the optimal stirring strategy recently proposed by Lin et al. ["Optimal stirring strategies for passive scalar mixing," J. Fluid Mech. 675, 465 (2011)], 10.1017/S0022112011000292 that determines the flow field that instantaneously maximizes the depletion of the H-1 mix-norm. In this work, we bridge some of the gap between the best available a priori analysis and simulation results. After recalling some previous analysis, we present an explicit example demonstrating finite-time perfect mixing with a finite energy constraint on the stirring flow. On the other hand, using a recent result by Wirosoetisno et al. ["Long time stability of a classical efficient scheme for two dimensional Navier-Stokes equations," SIAM J. Numer. Anal. 50(1), 126-150 (2012)], 10.1137/110834901 we establish that the H-1 mix-norm decays at most exponentially in time if the two-dimensional incompressible flow is constrained to have constant palenstrophy. Finite-time perfect mixing is thus ruled out when too much cost is incurred by small scale structures in the stirring. Direct numerical simulations in two dimensions suggest the impossibility of finite-time perfect mixing for flows with fixed power constraint and we conjecture an exponential lower bound on the H-1 mix-norm in this case. We also discuss some related problems from other areas of analysis that are similarly suggestive of an exponential lower bound for the H-1 mix-norm.

  6. Studying Mixing in Non-Newtonian Blue Maize Flour Suspensions Using Color Analysis

    PubMed Central

    Trujillo-de Santiago, Grissel; Rojas-de Gante, Cecilia; García-Lara, Silverio; Ballescá-Estrada, Adriana; Alvarez, Mario Moisés

    2014-01-01

    Background Non-Newtonian fluids occur in many relevant flow and mixing scenarios at the lab and industrial scale. The addition of acid or basic solutions to a non-Newtonian fluid is not an infrequent operation, particularly in Biotechnology applications where the pH of Non-Newtonian culture broths is usually regulated using this strategy. Methodology and Findings We conducted mixing experiments in agitated vessels using Non-Newtonian blue maize flour suspensions. Acid or basic pulses were injected to reveal mixing patterns and flow structures and to follow their time evolution. No foreign pH indicator was used as blue maize flours naturally contain anthocyanins that act as a native, wide spectrum, pH indicator. We describe a novel method to quantitate mixedness and mixing evolution through Dynamic Color Analysis (DCA) in this system. Color readings corresponding to different times and locations within the mixing vessel were taken with a digital camera (or a colorimeter) and translated to the CIELab scale of colors. We use distances in the Lab space, a 3D color space, between a particular mixing state and the final mixing point to characterize segregation/mixing in the system. Conclusion and Relevance Blue maize suspensions represent an adequate and flexible model to study mixing (and fluid mechanics in general) in Non-Newtonian suspensions using acid/base tracer injections. Simple strategies based on the evaluation of color distances in the CIELab space (or other scales such as HSB) can be adapted to characterize mixedness and mixing evolution in experiments using blue maize suspensions. PMID:25401332

  7. Scalable Lateral Mixing and Coherent Turbulence (LatMix) DRI: Turbulence-Resolving Simulations of Upper-Ocean Lateral Mixing

    DTIC Science & Technology

    2013-09-30

    The interaction of finescale and submesoscale upper-ocean mixing at fronts. OBJECTIVES Physically-based parameterizations of vertical mixed layer...dimensions of the oblong domain geometry on realized submesoscale instabilities. Figure 1: Surface buoyancy b from LES of baroclinic mixed layer

  8. Testing Mixed Distributions when the Mixing Distribution Is Known

    NASA Astrophysics Data System (ADS)

    Pommeret, Denys

    In this paper we present smooth goodness of fit tests for testing the mixture distribution of a sequence of i.i.d. random variables. We consider mixture models when the mixing distribution is known. We adapt a Schwarz’s criteria initiated by Ledwina (J Am Stat Assoc 89:1000-1005, 1994) and inspired by the Neyman (Skandinavian Aktuarial 20:149-199, 1937) smooth test procedure. A Monte Carlo study is provided in order to assess the performance of the test.

  9. Mixed methods for fitting the GEV distribution

    NASA Astrophysics Data System (ADS)

    Ailliot, Pierre; Thompson, Craig; Thomson, Peter

    2011-05-01

    The generalized extreme-value (GEV) distribution is widely used for modeling and characterizing extremes. It is a flexible three-parameter distribution that combines three extreme-value distributions within a single framework: the Gumbel, Frechet, and Weibull. Common methods used for estimating the GEV parameters are the method of maximum likelihood and the method of L-moments. This paper generalizes the mixed maximum likelihood and L-moments GEV estimation procedures proposed by Morrison and Smith (2002) and derives the asymptotic properties of the resulting estimators. Analytic expressions are given for the asymptotic covariance matrices in a number of important cases, including the estimators proposed by Morrison and Smith (2002). These expressions are verified by simulation and the efficiencies of the various estimators established. The asymptotic results are compared to those obtained for small to medium-size samples by simulation with the estimated parameters and quantiles assessed for accuracy and bias. Using simplified constraints for the support of the log likelihood, computational strategies and graphical tools are developed which lead to computationally efficient, numerically robust, estimation procedures suitable for automatic batch processing of many data sets. The methods are illustrated by application to annual maximum rainfall data at a large number of New Zealand locations. For Wellington, 24 h annual maximum rainfall over the period 1940-1999 is also considered within each phase of the Interdecadal Pacific Oscillation.

  10. Preconditioned Mixed Spectral Element Methods for Elasticity and Stokes Problems

    NASA Technical Reports Server (NTRS)

    Pavarino, Luca F.

    1996-01-01

    Preconditioned iterative methods for the indefinite systems obtained by discretizing the linear elasticity and Stokes problems with mixed spectral elements in three dimensions are introduced and analyzed. The resulting stiffness matrices have the structure of saddle point problems with a penalty term, which is associated with the Poisson ratio for elasticity problems or with stabilization techniques for Stokes problems. The main results of this paper show that the convergence rate of the resulting algorithms is independent of the penalty parameter, the number of spectral elements Nu and mildly dependent on the spectral degree eta via the inf-sup constant. The preconditioners proposed for the whole indefinite system are block-diagonal and block-triangular. Numerical experiments presented in the final section show that these algorithms are a practical and efficient strategy for the iterative solution of the indefinite problems arising from mixed spectral element discretizations of elliptic systems.

  11. Interpreting cost of ownership for mix-and-match lithography

    NASA Astrophysics Data System (ADS)

    Levine, Alan L.; Bergendahl, Albert S.

    1994-05-01

    Cost of ownership modeling is a critical and emerging tool that provides significant insight into the ways to optimize device manufacturing costs. The development of a model to deal with a particular application, mix-and-match lithography, was performed in order to determine the level of cost savings and the optimum ways to create these savings. The use of sensitivity analysis with cost of ownership allows the user to make accurate trade-offs between technology and cost. The use and interpretation of the model results are described in this paper. Parameters analyzed include several manufacturing considerations -- depreciation, maintenance, engineering and operator labor, floorspace, resist, consumables and reticles. Inherent in this study is the ability to customize this analysis for a particular operating environment. Results demonstrate the clear advantages of a mix-and-match approach for three different operating environments. These case studies also demonstrate various methods to efficiently optimize cost savings strategies.

  12. Model Verification of Mixed Dynamic Systems

    NASA Technical Reports Server (NTRS)

    Evensen, D. A.; Chrostowski, J. D.; Hasselman, T. K.

    1982-01-01

    MOVER uses experimental data to verify mathematical models of "mixed" dynamic systems. The term "mixed" refers to interactive mechanical, hydraulic, electrical, and other components. Program compares analytical transfer functions with experiment.

  13. A survey of mixed finite element methods

    NASA Technical Reports Server (NTRS)

    Brezzi, F.

    1987-01-01

    This paper is an introduction to and an overview of mixed finite element methods. It discusses the mixed formulation of certain basic problems in elasticity and hydrodynamics. It also discusses special techniques for solving the discrete problem.

  14. Extracellular Signals induce Glycoprotein M6a Clustering of Lipid-rafts and associated Signaling Molecules.

    PubMed

    Honda, Atsuko; Ito, Yasuyuki; Takahashi-Niki, Kazuko; Matsushita, Natsuki; Nozumi, Motohiro; Tabata, Hidenori; Takeuchi, Kosei; Igarashi, Michihiro

    2017-03-08

    Lipid-raft domains, where sphingolipids and cholesterol are enriched, concentrate signaling molecules. To examine how signaling protein complexes are clustered in rafts, we focused on the functions of glycoprotein M6a (GPM6a), which is expressed at a high concentration in developing mouse neurons. Using imaging of lipid-rafts, we found that GPM6a congregated in rafts in a GPM6a palmitoylation-dependent manner, thereby contributing to lipid-raft clustering. Additionally, we found that signaling proteins downstream of GPM6a, i.e., Rufy3, Rap2, and Tiam2/STEF, accumulated in lipid-rafts in a GPM6a-dependent manner, and that they were essential for laminin-dependent polarity during neurite formation in neuronal development. In utero RNAi targeting of GPM6a resulted in abnormally polarized neurons with multiple neurites. These results demonstrate that GPM6a induces the clustering of lipid-rafts, which supports the raft aggregation of its associated downstream molecules for acceleration of neuronal polarity determination. Thus, GPM6a acts as a signal transducer that responds to extracellular signals.SIGNIFICANCE STATEMENTLipid-raft domains, where sphingolipids and cholesterol are enriched, concentrate signaling molecules. We focused on glycoprotein M6a (GPM6a), which is expressed at a high concentration in developing neurons. Using imaging of lipid-rafts, we found that GPM6a congregated in rafts in a palmitoylation-dependent manner, thereby contributing to lipid-raft clustering. Additionally, we found that signaling proteins downstream of GPM6a accumulated in lipid-rafts in a GPM6a-dependent manner, and that they were essential for laminin-dependent polarity during neurite formation. In utero RNAi targeting of GPM6a resulted in abnormally polarized neurons with multiple neurites. These results demonstrate that GPM6a induces the clustering of lipid-rafts, which supports the raft aggregation of its associated downstream molecules for acceleration of polarity determination

  15. Single-interface Richtmyer-Meshkov turbulent mixing at the Los Alamos Vertical Shock Tube

    DOE PAGES

    Wilson, Brandon Merrill; Mejia Alvarez, Ricardo; Prestridge, Katherine Philomena

    2016-04-12

    We studied Mach number and initial conditions effects on Richtmyer–Meshkov (RM) mixing by the vertical shock tube (VST) at Los Alamos National Laboratory (LANL). At the VST, a perturbed stable light-to-heavy (air–SF6, A=0.64) interface is impulsively accelerated with a shock wave to induce RM mixing. We investigate changes to both large and small scales of mixing caused by changing the incident Mach number (Ma=1.3 and 1.45) and the three-dimensional (3D) perturbations on the interface. Simultaneous density (quantitative planar laser-induced fluorescence (PLIF)) and velocity (particle image velocimetry (PIV)) measurements are used to characterize preshock initial conditions and the dynamic shocked interface.more » Initial conditions and fluid properties are characterized before shock. Using two types of dynamic measurements, time series (N=5 realizations at ten locations) and statistics (N=100 realizations at a single location) of the density and velocity fields, we calculate several mixing quantities. Mix width, density-specific volume correlations, density–vorticity correlations, vorticity, enstrophy, strain, and instantaneous dissipation rate are examined at one downstream location. Results indicate that large-scale mixing, such as the mix width, is strongly dependent on Mach number, whereas small scales are strongly influenced by initial conditions. Lastly, the enstrophy and strain show focused mixing activity in the spike regions.« less

  16. Distinguishing the opponents promotes cooperation in well-mixed populations

    NASA Astrophysics Data System (ADS)

    Wardil, Lucas; da Silva, Jafferson K. L.

    2010-03-01

    Cooperation has been widely studied when an individual strategy is adopted against all coplayers. In this context, some extra mechanisms, such as punishment, reward, memory, and network reciprocity must be introduced in order to keep cooperators alive. Here, we adopt a different point of view. We study the adoption of different strategies against different opponents instead of adoption of the same strategy against all of them. In the context of the prisoner dilemma, we consider an evolutionary process in which strategies that provide more benefits are imitated and the players replace the strategy used in one of the interactions furnishing the worst payoff. Individuals are set in a well-mixed population, so that network reciprocity effect is excluded and both synchronous and asynchronous updates are analyzed. As a consequence of the replacement rule, we show that mutual cooperation is never destroyed and the initial fraction of mutual cooperation is a lower bound for the level of cooperation. We show by simulation and mean-field analysis that (i) cooperation dominates for synchronous update and (ii) only the initial mutual cooperation is maintained for asynchronous update. As a side effect of the replacement rule, an “implicit punishment” mechanism comes up in a way that exploitations are always neutralized providing evolutionary stability for cooperation.

  17. Distinguishing the opponents promotes cooperation in well-mixed populations.

    PubMed

    Wardil, Lucas; da Silva, Jafferson K L

    2010-03-01

    Cooperation has been widely studied when an individual strategy is adopted against all coplayers. In this context, some extra mechanisms, such as punishment, reward, memory, and network reciprocity must be introduced in order to keep cooperators alive. Here, we adopt a different point of view. We study the adoption of different strategies against different opponents instead of adoption of the same strategy against all of them. In the context of the prisoner dilemma, we consider an evolutionary process in which strategies that provide more benefits are imitated and the players replace the strategy used in one of the interactions furnishing the worst payoff. Individuals are set in a well-mixed population, so that network reciprocity effect is excluded and both synchronous and asynchronous updates are analyzed. As a consequence of the replacement rule, we show that mutual cooperation is never destroyed and the initial fraction of mutual cooperation is a lower bound for the level of cooperation. We show by simulation and mean-field analysis that (i) cooperation dominates for synchronous update and (ii) only the initial mutual cooperation is maintained for asynchronous update. As a side effect of the replacement rule, an "implicit punishment" mechanism comes up in a way that exploitations are always neutralized providing evolutionary stability for cooperation.

  18. Intrinsic Halide Segregation at Nanometer Scale Determines the High Efficiency of Mixed Cation/Mixed Halide Perovskite Solar Cells.

    PubMed

    Gratia, Paul; Grancini, Giulia; Audinot, Jean-Nicolas; Jeanbourquin, Xavier; Mosconi, Edoardo; Zimmermann, Iwan; Dowsett, David; Lee, Yonghui; Grätzel, Michael; De Angelis, Filippo; Sivula, Kevin; Wirtz, Tom; Nazeeruddin, Mohammad Khaja

    2016-12-14

    Compositional engineering of a mixed cation/mixed halide perovskite in the form of (FAPbI3)0.85(MAPbBr3)0.15 is one of the most effective strategies to obtain record-efficiency perovskite solar cells. However, the perovskite self-organization upon crystallization and the final elemental distribution, which are paramount for device optimization, are still poorly understood. Here we map the nanoscale charge carrier and elemental distribution of mixed perovskite films yielding 20% efficient devices. Combining a novel in-house-developed high-resolution helium ion microscope coupled with a secondary ion mass spectrometer (HIM-SIMS) with Kelvin probe force microscopy (KPFM), we demonstrate that part of the mixed perovskite film intrinsically segregates into iodide-rich perovskite nanodomains on a length scale of up to a few hundred nanometers. Thus, the homogeneity of the film is disrupted, leading to a variation in the optical properties at the micrometer scale. Our results provide unprecedented understanding of the nanoscale perovskite composition.

  19. Bounding CKM Mixing with a Fourth Family

    SciTech Connect

    Chanowitz, Michael S.

    2009-04-22

    CKM mixing between third family quarks and a possible fourth family is constrained by global fits to the precision electroweak data. The dominant constraint is from nondecoupling oblique corrections rather than the vertex correction to Z {yields} {bar b}b used in previous analyses. The possibility of large mixing suggested by some recent analyses of FCNC processes is excluded, but 3-4 mixing of the same order as the Cabbibo mixing of the first two families is allowed.

  20. Mixed wasted integrated program: Logic diagram

    SciTech Connect

    Mayberry, J.; Stelle, S.; O`Brien, M.; Rudin, M.; Ferguson, J.; McFee, J.

    1994-11-30

    The Mixed Waste Integrated Program Logic Diagram was developed to provide technical alternative for mixed wastes projects for the Office of Technology Development`s Mixed Waste Integrated Program (MWIP). Technical solutions in the areas of characterization, treatment, and disposal were matched to a select number of US Department of Energy (DOE) treatability groups represented by waste streams found in the Mixed Waste Inventory Report (MWIR).

  1. Micrometer-scale mixing with Pickering emulsions: biphasic reactions without stirring.

    PubMed

    Zhang, Wenjuan; Fu, Luman; Yang, Hengquan

    2014-02-01

    A general strategy that avoids stirring for organic/aqueous reactions involving solid catalysts is reported. The strategy involves converting a conventional biphasic system into a Pickering emulsion phase with micrometer-scale droplets ensuring good mixing. In test reactions, nitrotoluene reduction and epoxidation of allylic alcohols, the reaction efficiency is comparable to conventional stirrer-driven biphasic catalysis reaction systems. Short diffusion distances, arising from the compartmentalization of densely packed droplets, play an important role in boosting the reaction efficiency.

  2. Introduction strategies raise key questions.

    PubMed

    Finger, W R; Keller, S

    1995-09-01

    Key issues that must be considered before a new contraceptive is introduced center on the need for a trained provider to begin or terminate the method, its side effects, duration of use, method's ability to meet users' needs and preferences, and extra training or staff requirements. Logistics and economic issues to consider are identifying a dependable way of effectively supplying commodities, planning extra services needed for the method, and cost of providing the method. Each contraceptive method presents a different side effect pattern and burdens the service delivery setting differently. The strategy developed to introduce or expand the 3-month injectable Depo-Provera (DMPA) can be used for any method. It includes a needs assessment and addresses regulatory issues, service delivery policies and procedures, information and training, evaluation, and other concerns. Viet Nam's needs assessment showed that Norplant should not be introduced until the service delivery system becomes stronger. Any needs assessment for expansion of contraceptive services should cover sexually transmitted disease/HIV issues. A World Health Organization strategy helps officials identify the best method mix for local situations. Introductory strategies must aim to improve the quality of family planning programs and expand choices. Many begin by examining existing data and conducting interviews with policymakers, users, providers, and women's health advocates. Introductory programs for Norplant focus on provider training, adequate counseling and informed consent for users, and ready access to removal. They need a well-prepared service delivery infrastructure. The first phase of the DMPA introductory strategy for the Philippines comprised a social marketing campaign and DMPA introduction at public clinics in 10 pilot areas with strong service delivery. Successful AIDS prevention programs show that people tend to use barrier methods when they are available. USAID is currently studying

  3. Contact sensitization to Compositae mix in children.

    PubMed

    Belloni Fortina, Anna; Romano, Ilaria; Peserico, Andrea

    2005-11-01

    The prevalence of contact sensitization to Compositae mix was investigated in 641 consecutive children. Seventeen children (12 with atopic dermatitis) tested positive for Compositae mix. We suggest adding Compositae mix to a pediatric screening series when investigating airborne dermatitis in children with atopic dermatitis.

  4. 7 CFR 51.2112 - Mixed varieties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Sheller Run, U.S. Standard Sheller Run, U.S. No. 1 Whole and Broken may be designated as: “U.S. No. 1 Mixed;” “U.S. Select Sheller Run Mixed;” “U.S. Standard Sheller Run Mixed;” “U.S. No. 1 Whole and...

  5. Foam-Mixing-And-Dispensing Machine

    NASA Technical Reports Server (NTRS)

    Chong, Keith Y.; Toombs, Gordon R.; Jackson, Richard J.

    1996-01-01

    Time-and-money-saving machine produces consistent, homogeneously mixed foam, enhancing production efficiency. Automatically mixes and dispenses polyurethane foam in quantities specified by weight. Consists of cart-mounted, air-driven proportioning unit; air-activated mechanical mixing gun; programmable timer/counter, and controller.

  6. Pragmatism, Evidence, and Mixed Methods Evaluation

    ERIC Educational Resources Information Center

    Hall, Jori N.

    2013-01-01

    Mixed methods evaluation has a long-standing history of enhancing the credibility of evaluation findings. However, using mixed methods in a utilitarian way implicitly emphasizes convenience over engaging with its philosophical underpinnings (Denscombe, 2008). Because of this, some mixed methods evaluators and social science researchers have been…

  7. Moments, Mixed Methods, and Paradigm Dialogs

    ERIC Educational Resources Information Center

    Denzin, Norman K.

    2010-01-01

    I reread the 50-year-old history of the qualitative inquiry that calls for triangulation and mixed methods. I briefly visit the disputes within the mixed methods community asking how did we get to where we are today, the period of mixed-multiple-methods advocacy, and Teddlie and Tashakkori's third methodological moment. (Contains 10 notes.)

  8. A Call for Conducting Multivariate Mixed Analyses

    ERIC Educational Resources Information Center

    Onwuegbuzie, Anthony J.

    2016-01-01

    Several authors have written methodological works that provide an introductory- and/or intermediate-level guide to conducting mixed analyses. Although these works have been useful for beginning and emergent mixed researchers, with very few exceptions, works are lacking that describe and illustrate advanced-level mixed analysis approaches. Thus,…

  9. Mixed pneumoconiosis: silicosis, asbestosis, talcosis, and berylliosis.

    PubMed

    Mark, G J; Monroe, C B; Kazemi, H

    1979-06-01

    Mixed pneumoconiosis is pulmonary disease due to two or more inhaled mineral irritants. Chronic disease due to beryllium has not been a component of any described mixed pneumoconiosis. A man with occupational exposure to a combination of dusts developed severe pulmonary disease. Silicosis, talcosis, asbestosis, and berylliosis were all documented by an open biopsy of the lung. The varieties of mixed pneumoconiosis are summarized.

  10. Entropy of Mixing of Distinguishable Particles

    ERIC Educational Resources Information Center

    Kozliak, Evguenii I.

    2014-01-01

    The molar entropy of mixing yields values that depend only on the number of mixing components rather than on their chemical nature. To explain this phenomenon using the logic of chemistry, this article considers mixing of distinguishable particles, thus complementing the well-known approach developed for nondistinguishable particles, for example,…

  11. Qualitative Approaches to Mixed Methods Practice

    ERIC Educational Resources Information Center

    Hesse-Biber, Sharlene

    2010-01-01

    This article discusses how methodological practices can shape and limit how mixed methods is practiced and makes visible the current methodological assumptions embedded in mixed methods practice that can shut down a range of social inquiry. The article argues that there is a "methodological orthodoxy" in how mixed methods is practiced…

  12. Incorporating mixed rations and formulated grain mixes into the diet of grazing cows: Effects on milk composition and coagulation properties, and the yield and quality of Cheddar cheese.

    PubMed

    Auldist, M J; Greenwood, J S; Wright, M M; Hannah, M; Williams, R P W; Moate, P J; Wales, W J

    2016-06-01

    Effects of different strategies for feeding supplements to grazing dairy cows on the composition and coagulation properties of milk and the subsequent yield and quality of Cheddar cheese were measured. The experiment used milk from 72 Holstein-Friesian cows, averaging 45d in milk, fed according to 1 of 3 feeding strategies: (1) cows grazed a restricted allowance of perennial ryegrass pasture [approximately 14kg of dry matter (DM)/cow per day, to ground level] supplemented with milled wheat grain fed in the milking parlor and alfalfa hay offered in the paddock (control); (2) same pasture and allowance as control, supplemented with a formulated grain mix containing wheat grain, corn grain, and canola meal fed in the parlor and alfalfa hay fed in the paddock (FGM); or (3) same pasture and allowance as control, supplemented with a partial mixed ration comprising the same formulated grain mix but mixed with alfalfa hay and presented on a feed pad after each milking (PMR). For all strategies, supplements provided the same metabolizable energy and grain:forage ratio (78:22, DM basis). Within each feeding strategy, milk was sampled from cows receiving either 8 or 16kg (DM) of supplement/cow per day. There were 2 replicated groups of 6 cows per supplement amount per dietary strategy; approximately 250L of milk was sampled from each for analyses of composition and coagulation properties and the manufacture of Cheddar cheese. The experiment had a 14-d adaptation period and a 14-d measurement period. For cows fed according to the control strategy, those fed 16kg/cow per day produced milk with lower concentrations of milk fat than cows fed 8kg/cow per day. This effect was not observed for cows fed according to the FGM and PMR strategies. Milk from cows fed 16kg of DM/cow per day according to the control strategy yielded less Cheddar cheese than milk from cows fed according to the PMR strategy, with cheese yields from FGM cows being intermediate. Amount of supplement offered had

  13. Single-nucleotide resolution mapping of m6A and m6Am throughout the transcriptome

    PubMed Central

    Linder, Bastian; Grozhik, Anya V.; Olarerin-George, Anthony O.; Meydan, Cem; Mason, Christopher E.; Jaffrey, Samie R.

    2015-01-01

    N6-methyladenosine (m6A) is the most abundant modified base in eukaryotic mRNA and has been linked to diverse effects on mRNA fate. Current m6A mapping approaches localize m6A residues to 100–200 nt-long regions of transcripts. The precise position of m6A in mRNAs cannot be identified on a transcriptome-wide level because there are no chemical methods to distinguish between m6A and adenosine. Here we show that anti-m6A antibodies can induce specific mutational signatures at m6A residues after ultraviolet light-induced antibody-RNA crosslinking and reverse transcription. We find these antibodies similarly induce mutational signatures at N6,2′-O-dimethyladenosine (m6Am), a nucleotide found at the first encoded position of certain mRNAs. Using these mutational signatures, we map m6A and m6Am at single-nucleotide resolution in human and mouse mRNA and identify snoRNAs as a novel class of m6A-containing ncRNAs. PMID:26121403

  14. Essentiality of threonylcarbamoyladenosine (t6A), a universal tRNA modification, in bacteria

    PubMed Central

    Thiaville, Patrick C.; Yacoubi, Basma El; Köhrer, Caroline; Thiaville, Jennifer J.; Deutsch, Chris; Iwata-Reuyl, Dirk; Bacusmo, Jo Marie; Armengaud, Jean; Bessho, Yoshitaka; Wetzel, Collin; Cao, Xiaoyu; Limbach, Patrick A.; RajBhandary, Uttam L.; de Crécy-Lagard, Valérie

    2016-01-01

    Threonylcarbamoyladenosine (t6A) is a modified nucleoside universally conserved in tRNAs in all three kingdoms of life. The recently discovered genes for t6A synthesis, including tsaC and tsaD, are essential in model prokaryotes but not essential in yeast. These genes had been identified as antibacterial targets even before their functions were known. However, the molecular basis for this prokaryotic-specific essentiality has remained a mystery. Here, we show that t6A is a strong positive determinant for aminoacylation of tRNA by bacterial-type but not by eukaryotic-type isoleucyl-tRNA synthetases and might also be a determinant for the essential enzyme tRNAIle-lysidine synthetase. We confirm that t6A is essential in Escherichia coli and a survey of genome-wide essentiality studies shows that genes for t6A synthesis are essential in most prokaryotes. This essentiality phenotype is not universal in Bacteria as t6A is dispensable in Deinococcus radiodurans, Thermus thermophilus, Synechocystis PCC6803 and Streptococcus mutans. Proteomic analysis of t6A- D. radiodurans strains revealed an induction of the proteotoxic stress response and identified genes whose translation is most affected by the absence of t6A in tRNAs. Thus, although t6A is universally conserved in tRNAs, its role in translation might vary greatly between organisms. PMID:26337258

  15. Reverse Signaling by Semaphorin-6A Regulates Cellular Aggregation and Neuronal Morphology

    PubMed Central

    Perez-Branguli, Francesc; Zagar, Yvrick; Shanley, Daniel K.; Graef, Isabella A.; Chédotal, Alain; Mitchell, Kevin J.

    2016-01-01

    The transmembrane semaphorin, Sema6A, has important roles in axon guidance, cell migration and neuronal connectivity in multiple regions of the nervous system, mediated by context-dependent interactions with plexin receptors, PlxnA2 and PlxnA4. Here, we demonstrate that Sema6A can also signal cell-autonomously, in two modes, constitutively, or in response to higher-order clustering mediated by either PlxnA2-binding or chemically induced multimerisation. Sema6A activation stimulates recruitment of Abl to the cytoplasmic domain of Sema6A and phos¡phorylation of this cytoplasmic tyrosine kinase, as well as phosphorylation of additional cytoskeletal regulators. Sema6A reverse signaling affects the surface area and cellular complexity of non-neuronal cells and aggregation and neurite formation of primary neurons in vitro. Sema6A also interacts with PlxnA2 in cis, which reduces binding by PlxnA2 of Sema6A in trans but not vice versa. These experiments reveal the complex nature of Sema6A biochemical functions and the molecular logic of the context-dependent interactions between Sema6A and PlxnA2. PMID:27392094

  16. Thin film mixed potential sensors

    DOEpatents

    Garzon, Fernando H.; Brosha, Eric L.; Mukundan, Rangachary

    2007-09-04

    A mixed potential sensor for oxidizable or reducible gases and a method of making. A substrate is provided and two electrodes are formed on a first surface of the substrate, each electrode being formed of a different catalytic material selected to produce a differential voltage between the electrodes from electrochemical reactions of the gases catalyzed by the electrode materials. An electrolytic layer of an electrolyte is formed over the electrodes to cover a first portion of the electrodes from direct exposure to the gases with a second portion of the electrodes uncovered for direct exposure to the gases.

  17. Oscillatory multiphase flow strategy for chemistry and biology.

    PubMed

    Abolhasani, Milad; Jensen, Klavs F

    2016-07-19

    Continuous multiphase flow strategies are commonly employed for high-throughput parameter screening of physical, chemical, and biological processes as well as continuous preparation of a wide range of fine chemicals and micro/nano particles with processing times up to 10 min. The inter-dependency of mixing and residence times, and their direct correlation with reactor length have limited the adaptation of multiphase flow strategies for studies of processes with relatively long processing times (0.5-24 h). In this frontier article, we describe an oscillatory multiphase flow strategy to decouple mixing and residence times and enable investigation of longer timescale experiments than typically feasible with conventional continuous multiphase flow approaches. We review current oscillatory multiphase flow technologies, provide an overview of the advancements of this relatively new strategy in chemistry and biology, and close with a perspective on future opportunities.

  18. Optimization of Quantum Correlation in Cascaded Four-Wave Mixing

    NASA Astrophysics Data System (ADS)

    Feng, Jingliang; Jing, Jietai

    2016-12-01

    We propose a measurement strategy that can be used to optimize quantum correlation for a cascaded four-wave mixing (FWM) structure. By calculating the covariance matrix of a cascaded FWM structure, we can get all the correlations between any two parties in the outputs. We then calculate the eigenvalues and corresponding eigenmodes of the covariance matrix to find the squeezing degrees of the squeezed modes. Our theoretical model can explain our previous experimental results very well and is useful to optimize the squeezing degree in the cascaded FWM structure.

  19. Optimization of Quantum Correlation in Cascaded Four-Wave Mixing

    NASA Astrophysics Data System (ADS)

    Feng, Jingliang; Jing, Jietai

    2017-03-01

    We propose a measurement strategy that can be used to optimize quantum correlation for a cascaded four-wave mixing (FWM) structure. By calculating the covariance matrix of a cascaded FWM structure, we can get all the correlations between any two parties in the outputs. We then calculate the eigenvalues and corresponding eigenmodes of the covariance matrix to find the squeezing degrees of the squeezed modes. Our theoretical model can explain our previous experimental results very well and is useful to optimize the squeezing degree in the cascaded FWM structure.

  20. Diagnosis, Evaluation, and Treatment of Mixed Urinary Incontinence in Women

    PubMed Central

    Chughtai, Bilal; Laor, Leanna; Dunphy, Claire; Lee, Richard; Te, Alexis; Kaplan, Steven

    2015-01-01

    Mixed urinary incontinence (MUI) is a common clinical problem in the community and hospital setting. The broad definition of the term makes it difficult to diagnose, as well as determine effective treatment strategies. There are no current guidelines recommended for physicians. The estimated prevalence of this condition is approximately 30% in all women with incontinence. It has also been suggested that patients with MUI report more bothersome symptoms than either stress or urge incontinence; approximately 32% of 40- to 64-year-olds with MUI report symptoms of depression. The authors examine the diagnosis, evaluation, and treatment of patients with MUI. PMID:27222643

  1. A mixed methods assessment of coping with pediatric cancer

    PubMed Central

    Alderfer, Melissa A.; Deatrick, Janet A.; Marsac, Meghan L.

    2014-01-01

    The purpose of this study was to describe child coping and parent coping assistance with cancer-related stressors during treatment. Fifteen children (aged 6-12) with cancer and their parents (N = 17) completed semi-structured interviews and self-report measures to assess coping and coping assistance. Results suggest families utilized a broad array of approach and avoidance strategies to manage cancer and its treatment. Quantitative and qualitative assessments provided complementary and unique contributions to understanding coping among children with cancer and their parents. Using a mixed methods approach to assess coping provides a richer understanding of families’ experiences, which can better inform clinical practice. PMID:24428250

  2. Position of glycine substitutions in the triple helix of COL6A1, COL6A2, and COL6A3 is correlated with severity and mode of inheritance in collagen VI myopathies

    PubMed Central

    Butterfield, Russell J.; Foley, A. Reghan; Dastgir, Jahannaz; Asman, Stephanie; Dunn, Diane M.; Zou, Yaqun; Hu, Ying; Flanigan, Kevin M.; Swoboda, Kathryn J.; Winder, Thomas L.; Weiss, Robert B.; Bönnemann, Carsten G.

    2015-01-01

    Glycine substitutions in the conserved Gly-X-Y motif in the triple helical domain of collagen VI are the most commonly identified mutations in the collagen VI myopathies including Ullrich congenital muscular dystrophy, Bethlem myopathy, and intermediate phenotypes. We describe clinical and genetic characteristics of 97 individuals with glycine substitutions in the triple helical domain of COL6A1, COL6A2, or COL6A3 and add a review of 97 published cases, for a total of 194 cases. Clinical findings include severe, intermediate, and mild phenotypes even from patients with identical mutations. Intermediate phenotypes were most common, accounting for almost half of patients, emphasizing the importance of intermediate phenotypes to the overall phenotypic spectrum. Glycine substitutions in the triple helical domain are heavily clustered in a short segment N-terminal to the 17th Gly-X-Y triplet, where they are acting as dominants. The most severe cases are clustered in an even smaller region including Gly-X-Y triplets 10 to 15, accounting for only 5% of the triple helical domain. Our findings suggest that clustering of glycine substitutions in the N-terminal region of collagen VI is not based on features of the primary sequence. We hypothesize that this region may represent a functional domain within the triple helix. PMID:24038877

  3. Position of glycine substitutions in the triple helix of COL6A1, COL6A2, and COL6A3 is correlated with severity and mode of inheritance in collagen VI myopathies.

    PubMed

    Butterfield, Russell J; Foley, A Reghan; Dastgir, Jahannaz; Asman, Stephanie; Dunn, Diane M; Zou, Yaqun; Hu, Ying; Donkervoort, Sandra; Flanigan, Kevin M; Swoboda, Kathryn J; Winder, Thomas L; Weiss, Robert B; Bönnemann, Carsten G

    2013-11-01

    Glycine substitutions in the conserved Gly-X-Y motif in the triple helical (TH) domain of collagen VI are the most commonly identified mutations in the collagen VI myopathies including Ullrich congenital muscular dystrophy, Bethlem myopathy, and intermediate (INT) phenotypes. We describe clinical and genetic characteristics of 97 individuals with glycine substitutions in the TH domain of COL6A1, COL6A2, or COL6A3 and add a review of 97 published cases, for a total of 194 cases. Clinical findings include severe, INT, and mild phenotypes even from patients with identical mutations. INT phenotypes were most common, accounting for almost half of patients, emphasizing the importance of INT phenotypes to the overall phenotypic spectrum. Glycine substitutions in the TH domain are heavily clustered in a short segment N-terminal to the 17th Gly-X-Y triplet, where they are acting as dominants. The most severe cases are clustered in an even smaller region including Gly-X-Y triplets 10-15, accounting for only 5% of the TH domain. Our findings suggest that clustering of glycine substitutions in the N-terminal region of collagen VI is not based on features of the primary sequence. We hypothesize that this region may represent a functional domain within the triple helix.

  4. Structural and Functional Evidence for Testosterone Activation of GPRC6A in Peripheral Tissues

    DOE PAGES

    Pi, Min; Kapoor, Karan; Wu, Yunpeng; ...

    2015-01-01

    G protein-coupled receptor (GPCR) family C group 6 member A (GPRC6A) is a multiligand GPCR that is activated by cations, L-amino acids, and osteocalcin. GPRC6A plays an important role in the regulation of testosterone (T) production and energy metabolism in mice. T has rapid, transcription-independent (nongenomic) effects that are mediated by a putative GPCR. We previously found that T can activate GPRC6A in vitro, but the possibility that T is a ligand for GPRC6A remains controversial. Here, we demonstrate direct T binding to GPRC6A and construct computational structural models of GPRC6A that are used to identify potential binding poses ofmore » T. Mutations of the predicted binding site residues were experimentally found to block T activation of GPRC6A, in agreement with the modeling. Using Gpr6ca(-/-) mice, we confirmed that loss of GPRC6A resulted in loss of T rapid signaling responses and elucidated several biological functions regulated by GPRC6A-dependent T rapid signaling, including T stimulation of insulin secretion in pancreatic islets and enzyme expression involved in the biosynthesis of T in Leydig cells. Finally, we identified a stereo-specific effect of an R-isomer of a selective androgen receptor modulator that is predicted to bind to and shown to activate GPRC6A but not androgen receptor. Together, our data show that GPRC6A directly mediates the rapid signaling response to T and uncovers previously unrecognized endocrine networks.« less

  5. Structural and Functional Evidence for Testosterone Activation of GPRC6A in Peripheral Tissues

    SciTech Connect

    Pi, Min; Kapoor, Karan; Wu, Yunpeng; Ye, Ruisong; Senogles, Susan; Nishimoto, Satoru Kenneth; Hwang, Dong-Jin; Miller, Duane; Narayanan, Ramesh; Smith, Jeremy C.; Baudry, Jerome; Quarles, Leigh Darryl

    2015-01-01

    G protein-coupled receptor (GPCR) family C group 6 member A (GPRC6A) is a multiligand GPCR that is activated by cations, L-amino acids, and osteocalcin. GPRC6A plays an important role in the regulation of testosterone (T) production and energy metabolism in mice. T has rapid, transcription-independent (nongenomic) effects that are mediated by a putative GPCR. We previously found that T can activate GPRC6A in vitro, but the possibility that T is a ligand for GPRC6A remains controversial. Here, we demonstrate direct T binding to GPRC6A and construct computational structural models of GPRC6A that are used to identify potential binding poses of T. Mutations of the predicted binding site residues were experimentally found to block T activation of GPRC6A, in agreement with the modeling. Using Gpr6ca(-/-) mice, we confirmed that loss of GPRC6A resulted in loss of T rapid signaling responses and elucidated several biological functions regulated by GPRC6A-dependent T rapid signaling, including T stimulation of insulin secretion in pancreatic islets and enzyme expression involved in the biosynthesis of T in Leydig cells. Finally, we identified a stereo-specific effect of an R-isomer of a selective androgen receptor modulator that is predicted to bind to and shown to activate GPRC6A but not androgen receptor. Together, our data show that GPRC6A directly mediates the rapid signaling response to T and uncovers previously unrecognized endocrine networks.

  6. Structural and Functional Evidence for Testosterone Activation of GPRC6A in Peripheral Tissues

    PubMed Central

    Kapoor, Karan; Wu, Yunpeng; Ye, Ruisong; Senogles, Susan E.; Nishimoto, Satoru K.; Hwang, Dong-Jin; Miller, Duane D.; Narayanan, Ramesh; Smith, Jeremy C.; Baudry, Jerome

    2015-01-01

    G protein-coupled receptor (GPCR) family C group 6 member A (GPRC6A) is a multiligand GPCR that is activated by cations, L-amino acids, and osteocalcin. GPRC6A plays an important role in the regulation of testosterone (T) production and energy metabolism in mice. T has rapid, transcription-independent (nongenomic) effects that are mediated by a putative GPCR. We previously found that T can activate GPRC6A in vitro, but the possibility that T is a ligand for GPRC6A remains controversial. Here, we demonstrate direct T binding to GPRC6A and construct computational structural models of GPRC6A that are used to identify potential binding poses of T. Mutations of the predicted binding site residues were experimentally found to block T activation of GPRC6A, in agreement with the modeling. Using Gpr6ca−/− mice, we confirmed that loss of GPRC6A resulted in loss of T rapid signaling responses and elucidated several biological functions regulated by GPRC6A-dependent T rapid signaling, including T stimulation of insulin secretion in pancreatic islets and enzyme expression involved in the biosynthesis of T in Leydig cells. Finally, we identified a stereo-specific effect of an R-isomer of a selective androgen receptor modulator that is predicted to bind to and shown to activate GPRC6A but not androgen receptor. Together, our data show that GPRC6A directly mediates the rapid signaling response to T and uncovers previously unrecognized endocrine networks. PMID:26440882

  7. Can whales mix the ocean?

    NASA Astrophysics Data System (ADS)

    Lavery, T. J.; Roudnew, B.; Seuront, L.; Mitchell, J. G.; Middleton, J.

    2012-07-01

    Ocean mixing influences global climate and enhances primary productivity by transporting nutrient rich water into the euphotic zone. The contribution of the swimming biosphere to diapycnal mixing in the ocean has been hypothesised to occur on scales similar to that of tides or winds, however, the extent to which this contributes to nutrient transport and stimulates primary productivity has not been explored. Here, we introduce a novel method to estimate the diapycnal diffusivity that occurs as a result of a sperm whale swimming through a pycnocline. Nutrient profiles from the Hawaiian Ocean are used to further estimate the amount of nitrogen transported into the euphotic zone and the primary productivity stimulated as a result. We estimate that the 80 sperm whales that travel through an area of 104 km2 surrounding Hawaii increase diapycnal diffusivity by 10-6 m2 s-1 which results in the flux of 105 kg of nitrogen into the euphotic zone each year. This nitrogen input subsequently stimulates 6 × 105 kg of carbon per year. The nutrient input of swimming sperm whales is modest compared to dominant modes of nutrient transport such as nitrogen fixation but occurs more consistently and thus may provide the nutrients necessary to enable phytoplankton growth and survival in the absence of other seasonal and daily nutrient inputs.

  8. Mixing in straight shear layers

    NASA Technical Reports Server (NTRS)

    Karasso, P. S.; Mungal, M. G.

    1992-01-01

    Planar laser-induced fluorescence measurements were performed in a liquid plane mixing layer to extract the probability density function (pdf) of the mixture fraction of a passive scalar across the layer. Three Reynolds number (Re) cases were studied, 10,000, 33,000 and 90,000, with Re based on velocity difference and visual thickness. The results show that a non-marching pdf (central hump invariant from edge to edge of the layer) exists for Re = 10,000 but that a marching type pdf characterizes the Re = 33,000 and Re = 90,000 cases. For all cases, a broad range of mixture fraction values is found at each location across the layer. Streamwise and spanwise ramps across the layer, and structure-to-structure variation were observed and are believed to be responsible for the above behavior of the composition field. Tripping the boundary layer on the high-speed side of the splitter plate for each of the above three cases resulted in increased three-dimensionality and a change in the composition field. Average and average mixed fluid compositions are reported for all cases.

  9. [Mixed states: evolution of classifications].

    PubMed

    Pringuey, D; Cherikh, F; Giordana, B; Fakra, E; Dassa, D; Cermolacce, M; Belzeaux, R; Maurel, M; Azorin, J-M

    2013-12-01

    The nosological position of mixed states has followed the course of classifying methods in psychiatry, the steps of the invention of the clinic, progress in the organization of care, including the discoveries of psychopharmacology. The clinical observation of a mixture of symptoms emerging from usually opposite clinical conditions is classical. In the 70s, a syndromic specification fixed the main symptom combinations but that incongruous assortment failed to stabilize the nosological concept. Then stricter criteriology was proposed. To be too restrictive, a consensus operates a dimensional opening that attempts to meet the pragmatic requirements of nosology validating the usefulness of the class system. This alternation between rigor of categorization and return to a more flexible criteriological option reflects the search for the right balance between nosology and diagnosis. The definition of mixed states is best determined by their clinical and prognostic severity, related to the risk of suicide, their lower therapeutic response, the importance of their psychiatric comorbidities, anxiety, emotional lability, alcohol abuse. Trying to compensate for the lack of categorical definitions and better reflecting the clinical field problems, new definitions complement criteriology with dimensional aspects, particularly taking into account temperaments.

  10. Nanoscale Mixing of Soft Solids

    SciTech Connect

    Choi, Soo-Hyung; Lee, Sangwoo; Soto, Haidy E.; Lodge, Timothy P.; Bates, Frank S.

    2013-03-07

    Assessing the state of mixing on the molecular scale in soft solids is challenging. Concentrated solutions of micelles formed by self-assembly of polystyrene-block-poly(ethylene-alt-propylene) (PS-PEP) diblock copolymers in squalane (C{sub 30}H{sub 62}) adopt a body-centered cubic (bcc) lattice, with glassy PS cores. Utilizing small-angle neutron scattering (SANS) and isotopic labeling ({sup 1}H and {sup 2}H (D) polystyrene blocks) in a contrast-matching solvent (a mixture of squalane and perdeuterated squalane), we demonstrate quantitatively the remarkable fact that a commercial mixer can create completely random mixtures of micelles with either normal, PS(H), or deuterium-labeled, PS(D), cores on a well-defined bcc lattice. The resulting SANS intensity is quantitatively modeled by the form factor of a single spherical core. These results demonstrate both the possibility of achieving complete nanoscale mixing in a soft solid and the use of SANS to quantify the randomness.

  11. Tracer mixing at fracture intersections

    SciTech Connect

    Li, Guomin

    2001-02-10

    Discrete network models are one of the approaches used to simulate a dissolved contaminant, which is usually represented as a tracer in modeling studies, in fractured rocks. The discrete models include large numbers of individual fractures within the network structure, with flow and transport described on the scale of an individual fracture. Numerical simulations for the mixing characteristics and transfer probabilities of a tracer through a fracture intersection are performed for this study. A random-walk, particle-tracking model is applied to simulate tracer transport in fracture intersections by moving particles through space using individual advective and diffusive steps. The simulation results are compared with existing numerical and analytical solutions for a continuous intersection over a wide range of Peclet numbers. This study attempts to characterize the relative concentration at the outflow branches for a continuous intersection with different flow fields. The simulation results demonstrate that the mixing characteristics at the fracture intersections are a function not only of the Peclet number but also of the flow field pattern.

  12. Mixed waste characterization reference document

    SciTech Connect

    1997-09-01

    Waste characterization and monitoring are major activities in the management of waste from generation through storage and treatment to disposal. Adequate waste characterization is necessary to ensure safe storage, selection of appropriate and effective treatment, and adherence to disposal standards. For some wastes characterization objectives can be difficult and costly to achieve. The purpose of this document is to evaluate costs of characterizing one such waste type, mixed (hazardous and radioactive) waste. For the purpose of this document, waste characterization includes treatment system monitoring, where monitoring is a supplement or substitute for waste characterization. This document establishes a cost baseline for mixed waste characterization and treatment system monitoring requirements from which to evaluate alternatives. The cost baseline established as part of this work includes costs for a thermal treatment technology (i.e., a rotary kiln incinerator), a nonthermal treatment process (i.e., waste sorting, macronencapsulation, and catalytic wet oxidation), and no treatment (i.e., disposal of waste at the Waste Isolation Pilot Plant (WIPP)). The analysis of improvement over the baseline includes assessment of promising areas for technology development in front-end waste characterization, process equipment, off gas controls, and monitoring. Based on this assessment, an ideal characterization and monitoring configuration is described that minimizes costs and optimizes resources required for waste characterization.

  13. Mixing stops at the LHC

    SciTech Connect

    Agrawal, Prateek; Frugiuele, Claudia

    2014-01-01

    We study the phenomenology of a light stop NLSP in the presence of large mixing with either the first or the second generation. R-symmetric models provide a prime setting for this scenario, but our discussion also applies to the MSSM when a significant amount of mixing can be accommodated. In our framework the dominant stop decay is through the flavor violating mode into a light jet and the LSP in an extended region of parameter space. There are currently no limits from ATLAS and CMS in this region. We emulate shape-based hadronic SUSY searches for this topology, and find that they have potential sensitivity. If the extension of these analyses to this region is robust, we find that these searches can set strong exclusion limits on light stops. If not, then the flavor violating decay mode is challenging and may represent a blind spot in stop searches even at 13 TeV. Thus, an experimental investigation of this scenario is well motivated.

  14. Mixing stops at the LHC

    DOE PAGES

    Agrawal, Prateek; Frugiuele, Claudia

    2014-01-01

    We study the phenomenology of a light stop NLSP in the presence of large mixing with either the first or the second generation. R-symmetric models provide a prime setting for this scenario, but our discussion also applies to the MSSM when a significant amount of mixing can be accommodated. In our framework the dominant stop decay is through the flavor violating mode into a light jet and the LSP in an extended region of parameter space. There are currently no limits from ATLAS and CMS in this region. We emulate shape-based hadronic SUSY searches for this topology, and find thatmore » they have potential sensitivity. If the extension of these analyses to this region is robust, we find that these searches can set strong exclusion limits on light stops. If not, then the flavor violating decay mode is challenging and may represent a blind spot in stop searches even at 13 TeV. Thus, an experimental investigation of this scenario is well motivated.« less

  15. Diffusion in mixed solvents. II - The heat of mixing parameter

    NASA Technical Reports Server (NTRS)

    Carapellucci, P. A.

    1975-01-01

    Correlation of second-order rate constants for many reactions involving electron transfer between organic molecules, solvated electron reactions, iodine diffusion coefficients, and triplet state electron transfer reactions has been made with the heat of mixing parameter (HMP) for the aqueous binary solvent systems. The aqueous binary solvents studied are those containing methanol or ethanol (type I solvent); 1-propanol or tert-butyl alcohol (type II solvent); or sucrose or glycerol (type III solvent). A plot of the HMP vs. the diffusion parameter for each reaction yields superimposable curves for these reactions in a particular solvent mixture over the entire solvent mixture range, irrespective of the value of the reaction's rate constant or diffusion coefficient in water.

  16. CFD Analysis of Mixing Characteristics of Several Fuel Injectors at Hypervelocity Flow Conditions

    NASA Technical Reports Server (NTRS)

    Drozda, Tomasz G.; Drummond, J. Philip; Baurle, Robert A.

    2016-01-01

    CFD analysis is presented of the mixing characteristics and performance of three fuel injectors at hypervelocity flow conditions. The calculations were carried out using the VULCAN-CFD solver and Reynolds-Averaged Simulations (RAS). The high Mach number flow conditions match those proposed for the planned experiments conducted as a part of the Enhanced Injection and Mixing Project (EIMP) at the NASA Langley Research Center. The EIMP aims to investigate scramjet fuel injection and mixing physics, improve the understanding of underlying physical processes, and develop enhancement strategies and functional relationships relevant to flight Mach numbers greater than eight. Because of the high Mach number flow considered, the injectors consist of a fuel placement device, a strut; and a fluidic vortical mixer, a ramp. These devices accomplish the necessary task of distributing and mixing fuel into the supersonic cross-flow albeit via different strategies. Both of these devices were previously studied at lower flight Mach numbers where they exhibited promising performance in terms of mixing efficiency and total pressure recovery. For comparison, a flush-wall injector is also included. This type of injector generally represents the simplest method of introducing fuel into a scramjet combustor, however, at high flight Mach number conditions, the dynamic pressure needed to induce sufficient fuel penetration may be difficult to achieve along with other requirements such as achieving desired levels of fuel-to-air mixing at the required equivalence ratio. The three injectors represent the baseline configurations planned for the experiments. The current work discusses the mixing flow field behavior and differences among the three fuel injectors, mixing performance as described by the mixing efficiency and the total pressure recovery, and performance considerations based on the thrust potential.

  17. PREFACE: Turbulent Mixing and Beyond Turbulent Mixing and Beyond

    NASA Astrophysics Data System (ADS)

    Abarzhi, Snezhana I.; Gauthier, Serge; Rosner, Robert

    2008-10-01

    The goals of the International Conference `Turbulent Mixing and Beyond' are to expose the generic problem of Turbulence and Turbulent Mixing in Unsteady Flows to a wide scientific community, to promote the development of new ideas in tackling the fundamental aspects of the problem, to assist in the application of novel approaches in a broad range of phenomena, where the non-canonical turbulent processes occur, and to have a potential impact on technology. The Conference provides the opportunity to bring together scientists from the areas which include, but are not limited to, high energy density physics, plasmas, fluid dynamics, turbulence, combustion, material science, geophysics, astrophysics, optics and telecommunications, applied mathematics, probability and statistics, and to have their attention focused on the long-standing formidable task. The Turbulent Mixing and Turbulence in Unsteady Flows, including multiphase flows, plays a key role in a wide variety of phenomena, ranging from astrophysical to nano-scales, under either high or low energy density conditions. Inertial confinement and magnetic fusion, light-matter interaction and non-equilibrium heat transfer, properties of materials under high strain rates, strong shocks, explosions, blast waves, supernovae and accretion disks, stellar non-Boussinesq and magneto-convection, planetary interiors and mantle-lithosphere tectonics, premixed and non-premixed combustion, oceanography, atmospheric flows, unsteady boundary layers, hypersonic and supersonic flows, are a few examples to list. A grip on unsteady turbulent processes is crucial for cutting-edge technology such as laser-micromachining and free-space optical telecommunications, and for industrial applications in aeronautics. Unsteady Turbulent Processes are anisotropic, non-local and multi-scale, and their fundamental scaling, spectral and invariant properties depart from the classical Kolmogorov scenario. The singular aspects and similarity of the

  18. Expandable mixing section gravel and cobble eductor

    DOEpatents

    Miller, Arthur L.; Krawza, Kenneth I.

    1997-01-01

    In a hydraulically powered pump for excavating and transporting slurries in hich it is immersed, the improvement of a gravel and cobble eductor including an expandable mixing section, comprising: a primary flow conduit that terminates in a nozzle that creates a water jet internal to a tubular mixing section of the pump when water pressure is applied from a primary supply flow; a tubular mixing section having a center line in alignment with the nozzle that creates a water jet; a mixing section/exit diffuser column that envelopes the flexible liner; and a secondary inlet conduit that forms an opening at a bas portion of the column and adjacent to the nozzle and water jet to receive water saturated gravel as a secondary flow that mixes with the primary flow inside of the mixing section to form a combined total flow that exits the mixing section and decelerates in the exit diffuser.

  19. A Darwinian mechanism for biogenic ocean mixing

    NASA Astrophysics Data System (ADS)

    Katija, Kakani; Dabiri, John

    2009-11-01

    Recent observations of biogenic turbulence in the ocean have led to conflicting ideas regarding the contribution of animal swimming to ocean mixing. Previous measurements indicate elevated turbulent dissipation in the vicinity of large populations of planktonic animals swimming in concert. However, elevated turbulent dissipation is by itself insufficient proof of substantial biogenic mixing. We conducted field measurements of mixing efficiency by individual Mastigias sp. (a Palauan jellyfish) using a self-contained underwater velocimetry apparatus. These measurements revealed another mechanism that contributes to animal mixing besides wake turbulence. This mechanism was first described by Sir Charles Galton Darwin and is in fact the dominant mechanism of mixing by swimming animals. The efficiency of Darwin's mechanism (or drift) is dependent on animal shape rather than fluid length scale and, unlike turbulent wake mixing, is enhanced by the fluid viscosity. Therefore, it provides a means of biogenic mixing that can be equally effective in small plankton and large mammals.

  20. Uncarboxylated Osteocalcin and Gprc6a Axis Produce Intratumoral Androgens in Castration-Resistant Prostate Cancer

    DTIC Science & Technology

    2015-03-01

    at metastatic sites by the activity of androgen biosynthetic enzymes . Recent study shows that Gprc6a/Osteocalcin axis regulates physiological... enzymes . This data suggest that prostate cancer bone tumors hijack Osteocalcin/Gprc6a axis for the production of intratumoral androgens via...overexpression of certain androgen biosynthetic enzyme expression. Bone tumor expressed androgens promote disease progression via tumoral androgen production

  1. 17 CFR 240.6a-3 - Supplemental material to be filed by exchanges.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Supplemental material to be filed by exchanges. 240.6a-3 Section 240.6a-3 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) GENERAL RULES AND REGULATIONS, SECURITIES EXCHANGE ACT OF 1934 Rules and...

  2. Initial Investigation of Waste Feed Delivery Tank Mixing and Sampling Issues

    SciTech Connect

    Fort, James A.; Bamberger, Judith A.; Meyer, Perry A.; Stewart, Charles W.

    2007-10-01

    The Hanford tank farms contractor will deliver waste to the Waste Treatment Plant (WTP) from a staging double-shell tank. The WTP broadly classifies waste it receives in terms of “Envelopes,” each with different limiting properties and composition ranges. Envelope A, B, and C wastes are liquids that can include up to 4% entrained solids that can be pumped directly from the staging DST without mixing. Envelope D waste contains insoluble solids and must be mixed before transfer. The mixing and sampling issues lie within Envelope D solid-liquid slurries. The question is how effectively these slurries are mixed and how representative the grab samples are that are taken immediately after mixing. This report summarizes the current state of knowledge concerning jet mixing of wastes in underground storage tanks. Waste feed sampling requirements are listed, and their apparent assumption of uniformity by lack of a requirement for sample representativeness is cited as a significant issue. The case is made that there is not an adequate technical basis to provide such a sampling regimen because not enough is known about what can be achieved in mixing and distribution of solids by use of the baseline submersible mixing pump system. A combined mixing-sampling test program is recommended to fill this gap. Historical Pacific Northwest National Laboratory project and tank farms contractor documents are used to make this case. A substantial investment and progress are being made to understand mixing issues at the WTP. A summary of the key WTP activities relevant to this project is presented in this report. The relevant aspects of the WTP mixing work, together with a previously developed scaled test strategy for determining solids suspension with submerged mixer pumps (discussed in Section 3) provide a solid foundation for developing a path forward.

  3. Differences in bone-cement porosity by vacuum mixing, centrifugation, and hand mixing.

    PubMed

    Macaulay, William; DiGiovanni, Christopher W; Restrepo, Andres; Saleh, Khaled J; Walsh, Heather; Crossett, Lawrence S; Peterson, Margaret G E; Li, Stephen; Salvati, Eduardo A

    2002-08-01

    The mean pore size and percent porosity of vacuum-mixed cement were compared with centrifuged cement and cement hand mixed by skilled specialized operating room technicians. Centrifuged cement samples had the smallest mean pore size when compared with vacuum-mixed specimens. The mean pore size for the hand-mixed specimens was intermediate and not significantly different from the other 2 mixing techniques. Results were reversed, however, for mean percent porosity. Centrifuged cement had the highest percent porosity; vacuum-mixed cement, the lowest; and hand-mixed cement, intermediate. The porosity of vacuum-mixed Simplex P (Howmedica, Rutherford, NJ) bone-cement was similar from the initial to the remnant cement extruded from the cement gun. There was no reduced cement porosity with vacuum mixing or centrifugation as anticipated. Reversion to hand mixing by highly skilled technicians could result in a significant cost savings without negative effects on cement porosity.

  4. Transcriptome sequencing of neurologic diseases associated genes in HHV-6A infected human astrocyte

    PubMed Central

    Tang, Junwei; Lu, Shuai; Feng, Dongju; Cheng, Ci; Qing, Lanqun; Yao, Kun; Chen, Yun

    2016-01-01

    Human Herpesvirus 6 (HHV-6) has been involved in the development of several central nervous system (CNS) diseases, such as Alzheimer's disease, multiple sclerosis and glioma. In order to identify the pathogenic mechanism of HHV-6A infection, we carried out mRNA-seq study of human astrocyte HA1800 cell with HHV-6A GS infection. Using mRNA-seq analysis of HA1800-control cells with HA1800-HHV-6A GS cells, we identified 249 differentially expressed genes. After investigating these candidate genes, we found seven genes associated with two or more CNS diseases: CTSS, PTX3, CHI3L1, Mx1, CXCL16, BIRC3, and BST2. This is the first transcriptome sequencing study which showed the significant association of these genes between HHV-6A infection and neurologic diseases. We believe that our findings can provide a new perspective to understand the pathogenic mechanism of HHV-6A infection and neurologic diseases. PMID:27344170

  5. Microgravity acoustic mixing for particle cloud combustors

    NASA Technical Reports Server (NTRS)

    Pla, Frederic; Rubinstein, Robert I.

    1990-01-01

    Experimental and theoretical investigations of acoustic mixing procedures designed to uniformly distribute fuel particles in a combustion tube for application in the proposed Particle Cloud Combustion Experiment (PCCE) are described. Two acoustic mixing methods are investigated: mixing in a cylindrical tube using high frequency spinning modes generated by suitably phased, or quadrature speakers, and acoustic premixing in a sphere. Quadrature mixing leads to rapid circumferential circulation of the powder around the tube. Good mixing is observed in the circulating regions. However, because axial inhomogeneities are necessarily present in the acoustic field, this circulation does not extend throughout the tube. Simultaneous operation of the quadrature-speaker set and the axial-speaker was observed to produce considerably enhanced mixing compared to operation of the quadrature-speaker set alone. Mixing experiments using both types of speakers were free of the longitudinal powder drift observed using axial-speakers alone. Vigorous powder mixing was obtained in the sphere for many normal modes: however, in no case was the powder observed to fill the sphere entirely. Theoretical analysis indicated that mixing under steady conditions cannot fill more than a hemisphere except under very unusual conditions. Premixing in a hemisphere may be satisfactory; otherwise, complete mixing in microgravity might be possible by operating the speaker in short bursts. A general conclusion is that acoustic transients are more likely to produce good mixing than steady state conditions. The reason is that in steady conditions, flow structures like nodal planes are possible and often even unavoidable. These tend to separate the mixing region into cells across which powder cannot be transferred. In contrast, transients not only are free of such structures, they also have the characteristics, desirable for mixing, of randomness and disorder. This conclusion is corroborated by mixing

  6. Strategies for Sustainable Communities

    EPA Pesticide Factsheets

    The guidebook offers potential strategies for reducing greenhouse gas emissions using smart growth strategies, indicators to track progress, and resources for 10 community types ranging from major cities to rural communities.

  7. WILDLIFE RESEARCH STRATEGY

    EPA Science Inventory

    This document describes a strategy for conducting wildlife effects research within the U.S. Environmental Protection Agencys (EPA) National Health and Environmental Effects Research Laboratory (NHEERL). The NHEEL wildlife research strategy is designed to address critical researc...

  8. Expression of COL6A1 predicts prognosis in cervical cancer patients.

    PubMed

    Hou, Teng; Tong, Chongjie; Kazobinka, Gallina; Zhang, Weijing; Huang, Xin; Huang, Yongwen; Zhang, Yanna

    2016-01-01

    COL6A1 has been shown to play an important role in tumor initiation and progression. The present study is to investigate the clinical significance of COL6A1 in cervical cancer. In this study, the COL6A1 expression levels in 10 paired cervical cancer tissues and the adjacent non-tumor tissues were examined by real-time PCR. The expression of COL6A1 protein was examined in 162 cervical cancer samples by immunohistochemistry, and the correlation of COL6A1 expression with clinicopathologic factors was analyzed. The overall and recurrent-free survival rates were estimated using Kaplan-Meier method and compared with the log-rank test. The prognostic analysis was carried out with multivariate Cox regressions model. The result showed that COL6A1 expression was up-regulated in cervical cancer tissues in compared with that in non-tumor tissues. High expression of COL6A1 was significantly correlated with FIGO stage (P<0.001), tumor size (P=0.025) and lymph node metastasis (P=0.028) of the disease. Moreover, survival analysis showed that high expression of COL6A1 was significantly associated with poorer overall (OS) and recurrent free (RFS) survival (p=0.004 and =0.001, respectively) of cervical cancer patients. Multivariate analysis suggested that COL6A1 expression was an independent prognostic marker of cervical cancer (P=0.029). Thus, COL6A1 may serve as an oncogene in the initiation and progression of cervical cancer, and as a predictor of poor prognosis in cervical cancer patients.

  9. Promise for Enhancing Children's Reading Attitudes through Peer Reading: A Mixed Method Approach

    ERIC Educational Resources Information Center

    Lee, Youngju

    2014-01-01

    Peer-Assisted Learning Strategies (PALS) was implemented for supplementary reading classes in a Korean elementary school. The treatment group children were exposed to PALS during 20 min sessions, 4 times a week, for 8 weeks. The impacts of PALS were investigated in 3 aspects using a mixed-methods approach: improvement in reading attitudes, reading…

  10. Mixing versus Sorting in Schooling: Evidence from the Equalization Policy in South Korea

    ERIC Educational Resources Information Center

    Kim, Taejong; Lee, Ju-Ho; Lee, Young

    2008-01-01

    This paper employs the difference-in-differences empirical strategy and quantile regressions to analyze the effects of sorting and mixing on the academic performance of high school students in South Korea. In Korea, about half of high schools are subject to the equalization policy (EP), and must therefore passively accept students randomly…

  11. A Mixed-Methods Study Comparing the Perceived Spiritual Benefits of Topical and Extended Scripture Memorization

    ERIC Educational Resources Information Center

    Johnson, Andy

    2010-01-01

    The purpose of this mixed-methods study is to compare the perceived benefits of topical Scripture memorization (TSM) with the perceived benefits of extended Scripture memorization (ESM) to explore if one strategy fosters more perceived spiritual growth than the other. A baseline for the study is established by investigating the historical,…

  12. Intersectionality in Context: A Mixed-Methods Approach to Researching the Faculty Experience

    ERIC Educational Resources Information Center

    Pifer, Meghan J.

    2011-01-01

    This article describes a mixed-methods approach to integrating the methodological tools of social network analysis and qualitative research to explore intersectionality as it pertains to faculty experiences in institutional contexts. These research strategies, employed at the individual and aggregate levels, can be useful tools as institutions aim…

  13. Job integration factors as predictors of travel nurse job performance: a mixed-methods study.

    PubMed

    Tuttas, Carol A

    2015-01-01

    Concerns about insufficient work setting familiarity and orientation of temporary nurses affecting job performance are documented in the literature. This mixed-methods study identified unique needs and characteristics of travel nurses, using Web conference focus groups and an Internet survey to reach this geographically dispersed workforce. New knowledge emerged to facilitate more effective travel nurse orientation strategies.

  14. Marketing for a Web-Based Master's Degree Program in Light of Marketing Mix Model

    ERIC Educational Resources Information Center

    Pan, Cheng-Chang

    2012-01-01

    The marketing mix model was applied with a focus on Web media to re-strategize a Web-based Master's program in a southern state university in U.S. The program's existing marketing strategy was examined using the four components of the model: product, price, place, and promotion, in hopes to repackage the program (product) to prospective students…

  15. Understanding Student Stress and Coping in Elementary School: A Mixed-Method, Longitudinal Study

    ERIC Educational Resources Information Center

    Sotardi, Valerie A.

    2016-01-01

    This mixed-method, longitudinal study examined daily school stress and coping strategies of elementary schoolchildren in the United States. Students (n = 65) between the ages of 7 and 11 years reported daily school stress measures for 8 weeks and completed individual stress and coping interviews. Results highlight critical relations between…

  16. More than Method?: A Discussion of Paradigm Differences within Mixed Methods Research

    ERIC Educational Resources Information Center

    Harrits, Gitte Sommer

    2011-01-01

    This article challenges the idea that mixed methods research (MMR) constitutes a coherent research paradigm and explores how different research paradigms exist within MMR. Tracing paradigmatic differences at the level of methods, ontology, and epistemology, two MMR strategies are discussed: nested analysis, recently presented by the American…

  17. "GREENER" CHEMICAL SYNTHETIC PROCESSES USING ENZYMATIC, MECHANOCHEMICAL MIXING, OR MICROWAVE AND ULTRASOUND IRRADIATION

    EPA Science Inventory

    Several newer strategies, such as solvent-free (dry media), solid-supported with and without microwave (MW) irradiation, and mechanochemical mixing (grinding); and the use of room temperature ionic liquids, supercritical carbon dioxide, and water as reaction media that can be com...

  18. A Mixed-Methods Analysis of Reading Intervention Effectiveness in the Community College

    ERIC Educational Resources Information Center

    Dreyer, Melissa

    2012-01-01

    The purpose of this mixed-methods study was to determine if, when implemented at one two-year post-secondary institution, such K-12 reading comprehension strategies as concept mapping, think-aloud protocols, and Question-Answer Relationships (QAR) elicit change in COMPASS reading test scores of adult readers. Data was collected over four academic…

  19. Nanostructuring Mixed-Dimensional Perovskites: A Route Toward Tunable, Efficient Photovoltaics.

    PubMed

    Koh, Teck Ming; Shanmugam, Vignesh; Schlipf, Johannes; Oesinghaus, Lukas; Müller-Buschbaum, Peter; Ramakrishnan, N; Swamy, Varghese; Mathews, Nripan; Boix, Pablo P; Mhaisalkar, Subodh G

    2016-05-01

    2D perovskites is one of the proposed strategies to enhance the moisture resistance, since the larger organic cations can act as a natural barrier. Nevertheless, 2D perovskites hinder the charge transport in certain directions, reducing the solar cell power conversion efficiency. A nanostructured mixed-dimensionality approach is presented to overcome the charge transport limitation, obtaining power conversion efficiencies over 9%.

  20. The Presentation of Self in Letters of Application: A Mixed-Method Approach

    ERIC Educational Resources Information Center

    Soroko, Emilia

    2012-01-01

    The application letter, as the first phase of employment-seeking, is an opportunity for a job applicant to make a favorable impression on a potential employer. In the current study, the author used a mixed-method approach to empirically explore strategies for self-presentation in job application letters and determine the methods used in the…

  1. Linking Faculty Development to Community College Student Achievement: A Mixed Methods Approach

    ERIC Educational Resources Information Center

    Elliott, Robert W.; Oliver, Diane E.

    2016-01-01

    Using a mixed methods, multilevel research design, this pilot inquiry explored the relationship between college faculty professional development and the academic achievement of diverse students by coupling two separate links: (a) the effects that professional development activities have on improving teaching strategies, and (b) the effects these…

  2. Online Strategy Games.

    ERIC Educational Resources Information Center

    Dye, Bryan

    2002-01-01

    A strategy game is an online interactive game that requires thinking in order to be played at its best and whose winning strategy is not obvious. Provides information on strategy games that are written in Java or JavaScript and freely available on the web. (KHR)

  3. The Hermes safety strategy

    NASA Astrophysics Data System (ADS)

    Rosso, R.

    1992-08-01

    The principal safety objectives and safety assurance strategies of the Hermes space vehicle program are discussed. The highlights of the Hermes safety assurance strategy are reviewed with particular reference to risk identification, risk evaluation, risk reduction, and risk acceptance. The application of the safety assurance strategy to Phase I definition studies and safety objectives of the Hermes X 2000 mission are then discussed.

  4. Strategies for retaining midcareer nurses.

    PubMed

    McGillis Hall, Linda; Lalonde, Michelle; Dales, Lorraine; Peterson, Jessica; Cripps, Lauren

    2011-12-01

    One method of reducing predicted shortages because of the aging nursing workforce is to increase retention. Few studies have examined the unique needs of midcareer nurses. A mixed-method approach including surveys and focus groups was used to identify key retention strategies and desires for midcareer nurses. Salary, benefits, positive working relationships, flexible scheduling, and the opportunity for continued education were identified as key retention strategies from this study. Registered nurses in this study reported higher perceptions of their work and work environment than licensed practical nurses did. Differences in work outcomes were evident across sectors, with community nurses reporting higher levels of job satisfaction and perceptions of work quality than nurses in acute and long-term care. Findings suggest that recruitment opportunities may exist with midcareer nurses seeking employment to return to work after time off to have a family. Proactive retention policies that focus on the needs of midcareer nurses would demonstrate a commitment and interest in keeping them in their work positions and in the profession.

  5. Optimal generator bidding strategies for power and ancillary services

    NASA Astrophysics Data System (ADS)

    Morinec, Allen G.

    As the electric power industry transitions to a deregulated market, power transactions are made upon price rather than cost. Generator companies are interested in maximizing their profits rather than overall system efficiency. A method to equitably compensate generation providers for real power, and ancillary services such as reactive power and spinning reserve, will ensure a competitive market with an adequate number of suppliers. Optimizing the generation product mix during bidding is necessary to maximize a generator company's profits. The objective of this research work is to determine and formulate appropriate optimal bidding strategies for a generation company in both the energy and ancillary services markets. These strategies should incorporate the capability curves of their generators as constraints to define the optimal product mix and price offered in the day-ahead and real time spot markets. In order to achieve such a goal, a two-player model was composed to simulate market auctions for power generation. A dynamic game methodology was developed to identify Nash Equilibria and Mixed-Strategy Nash Equilibria solutions as optimal generation bidding strategies for two-player non-cooperative variable-sum matrix games with incomplete information. These games integrated the generation product mix of real power, reactive power, and spinning reserve with the generators's capability curves as constraints. The research includes simulations of market auctions, where strategies were tested for generators with different unit constraints, costs, types of competitors, strategies, and demand levels. Studies on the capability of large hydrogen cooled synchronous generators were utilized to derive useful equations that define the exact shape of the capability curve from the intersections of the arcs defined by the centers and radial vectors of the rotor, stator, and steady-state stability limits. The available reactive reserve and spinning reserve were calculated given a

  6. Mediterranean outflow mixing and dynamics.

    PubMed

    Price, J F; Baringer, M O; Lueck, R G; Johnson, G C; Ambar, I; Parrilla, G; Cantos, A; Kennelly, M A; Sanford, T B

    1993-02-26

    The Mediterranean Sea produces a salty, dense outflow that is strongly modified by entrainment as it first begins to descend the continental slope in the eastern Gulf of Cadiz. The current accelerates to 1.3 meters per second, which raises the internal Froude number above 1, and is intensely turbulent through its full thickness. The outflow loses about half of its density anomaly and roughly doubles its volume transport as it entrains less saline North Atlantic Central water. Within 100 kilometers downstream, the current is turned by the Coriolis force until it flows nearly parallel to topography in a damped geostrophic balance. The mixed Mediterranean outflow continues westward, slowly descending the continental slope until it becomes neutrally buoyant in the thermocline where it becomes an important water mass.

  7. Mixing in SRS Closure Business Unit Applications

    SciTech Connect

    POIRIER, MICHAELR.

    2004-06-23

    The following equipment is commonly used to mix fluids: mechanical agitators, jets (pumps), shrouded axial impeller mixers (Flygt mixers), spargers, pulsed jet mixers, boiling, static mixers, falling films, liquid sprays, and thermal convection. This discussion will focus on mechanical agitators, jets, shrouded axial impeller mixers, spargers, and pulsed jet mixers, as these devices are most likely to be employed in Savannah River Site (SRS) Closure Business applications. In addressing mixing problems in the SRS Tank Farm, one must distinguish between different mixing objectives. These objectives include sludge mixing (e.g., Extended Sludge Processing), sludge retrieval (e.g., sludge transfers between tanks), heel retrieval (e.g., Tanks 18F and 19F), chemical reactions (e.g., oxalic acid neutralization) and salt dissolution. For example, one should not apply sludge mixing guidelines to heel removal applications. Mixing effectiveness is a function of both the mixing device (e.g., slurry pump, agitator, air sparger) and the properties of the material to be mixed (e.g., yield stress, viscosity, density, and particle size). The objective of this document is to provide background mixing knowledge for the SRS Closure Business Unit personnel and to provide general recommendations for mixing in SRS applications.

  8. Evolutionary behavior of generalized zero-determinant strategies in iterated prisoner's dilemma

    NASA Astrophysics Data System (ADS)

    Liu, Jie; Li, Y.; Xu, C.; Hui, P. M.

    2015-07-01

    We study the competition and strategy selections between a class of generalized zero-determinant (ZD) strategies and the classic strategies of always cooperate (AllC), always defect (AllD), tit-for-tat (TFT), and win-stay-lose-shift (WSLS) strategies in an iterated prisoner's dilemma comprehensively. Using the generalized ZD strategy, a player could get a payoff that is χ (χ > 1) times that of his opponent's, when the payoff is measured with respect to a referencing baseline parameterized by 0 ≤ σ ≤ 1. Varying σ gives ZD strategies of tunable generosity from the extortionate-like ZD strategy for σ ≪ 1 to the compliance-like strategy at σ ≈ 1. Expected payoffs when ZD strategy competes with each one of the classic strategies are presented. Strategy evolution based on adopting the strategy of a better performing neighbor is studied in a well-mixed population of finite size and a population on a square lattice. Depending on the parameters, extortion-like strategies may not be evolutionarily stable despite a positive surplus over cooperative strategies, while extortion-like strategies may dominate or coexist with other strategies that tend to defect despite a negative surplus. The dependence of the equilibrium fraction of ZD strategy players on the model parameters in a well-mixed population can be understood analytically by comparing the average payoffs to the competing strategies. On a square lattice, the success of the ZD strategy can be qualitatively understood by focusing on the relative alignments of the finite number of payoff values that the two competing strategies could attain when the spatial structure is imposed. ZD strategies with properly chosen generosity could be more successful in evolutionary competing systems.

  9. Association of MMP-3 (-1612 5A/6A) polymorphism with knee osteoarthritis in Thai population.

    PubMed

    Honsawek, Sittisak; Malila, Somkiat; Yuktanandana, Pongsak; Tanavalee, Aree; Deepaisarnsakul, Benjamad; Parvizi, Javad

    2013-02-01

    Osteoarthritis (OA) is a degenerative joint disorder resulting in destruction of articular cartilage, osteophyte formation, and subchondral bone sclerosis. In recent years, numerous genetic factors have been identified and implicated in causing osteoarthritis. One such genetic defect is a single nucleotide polymorphism at position -1612 of matrix metalloproteinase-3 (MMP-3) promoter region, known to lead to three possible genotypes, 5A/5A, 6A/6A, and 5A/6A. The purpose of this study was to investigate the association of MMP-3 -1612 5A/6A gene polymorphism with knee osteoarthritis in Thai population. Genotype distributions and allelic frequencies of MMP-3 -1612 5A/6A polymorphism were investigated in 200 participants (100 patients with knee osteoarthritis and 100 healthy controls). Genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism. There was no statistically significant difference between the groups with respect to genotype distribution (P > 0.05). The 5A allele frequency was indicated as 15.5 %, and 6A allele was as 84.5 % in OA patients, whereas it was 10-90 % in the control group. Accordingly, the present study has indicated that the -1612 5A/6A polymorphism genotypes of MMP-3 gene promoter do not play a role in the development of osteoarthritis in the Thai population.

  10. Heterologous expression of codon optimized Trichoderma reesei Cel6A in Pichia pastoris.

    PubMed

    Sun, Fubao Fuelbiol; Bai, Renhui; Yang, Huimin; Wang, Fei; He, Jing; Wang, Chundi; Tu, Maobing

    2016-10-01

    The Cel6A deficiency has become one of the limiting factors for cellulose saccharification in biochemical conversion of cellulosic biomass to fuels and chemicals. The work attempted to use codon optimization to enhance Trichoderma reesei Cel6A expression in Pichia pastoris. Two recombinants P. pastoris GS115 containing AOX1 and GAP promotors were successfully constructed, respectively. The optimal temperatures and pHs of the expressed Cel6A from two recombinants were consistent with each other, were also in the extremely similar range to that reported on the native Cel6A from T. reesei. Based on the shake flask fermentation, AOX1 promotor enabled the recombinant to produce 265U/L and 300mg/L of the Cel6A enzyme, and the GAP promotor resulted in 145U/L and 200mg/L. High cell density fed batch (HCDFB) fermentation significantly improved the enzyme titer (1100U/L) and protein yield (2.0g/L) for the recombinant with AOX1 promotor. Results have showed that the AOX1 promotor is more suitable than the GAP for the Cel6A expression in P. pastoris. And the HCDFB cultivation is a favorable way to express the Cel6A highly in the methanol inducible yeast.

  11. Classroom Management Strategies and Behavioral Interventions to Support Academic Achievement

    ERIC Educational Resources Information Center

    Gilpatrick, Robin Sue Holzworth

    2010-01-01

    This mixed method project study identified the need for effective classroom management strategies to dissuade student noncompliant behavior and to ensure academic success for all students. Enhancing classroom management practices is vital to improved student achievement and teacher self-efficacy. Within a constructivist framework, it is critical…

  12. Improving Student Retention: A Guide to Successful Strategies.

    ERIC Educational Resources Information Center

    Martinez, Paul

    This guide is designed to share the experiences of 25 British further education colleges and adult education services that have developed demonstrably successful strategies to improve student retention. An introduction discusses the report's background, content, and format. The format mixes thematic presentation with mini-case studies and…

  13. Empowering Teachers: Characteristics, Strategies, and Practices of Successful Principals

    ERIC Educational Resources Information Center

    Ellis, Cailin Patrice

    2012-01-01

    This study implemented an exploratory mixed-methods design to better understand how the characteristics of a principal, specifically the strategies, behaviors, and actions, lead to the perception of empowerment as perceived by the teachers themselves. An expert panel identified three "highly successful" principals assigned to elementary…

  14. Reading Strategies among ESL Malaysian Secondary School Students

    ERIC Educational Resources Information Center

    Semtin, Semry Anak; Maniam, Mahendran

    2015-01-01

    This study aimed to investigate the types of cognitive and metacognitive reading strategies employed by secondary school students in Malaysia to improve their comprehension. The study employed a mixed-method approach which involves the instruments of a questionnaire and an interview. This study was conducted at SMK Kapit, involving ninety Form 4…

  15. Mixed and Low-Level Waste Treatment Facility project

    SciTech Connect

    Not Available

    1992-04-01

    Mixed and low-level wastes generated at the Idaho National Engineering Laboratory (INEL) are required to be managed according to applicable State and Federal regulations, and Department of Energy Orders that provide for the protection of human health and the environment. The Mixed and Low-Level Waste Treatment Facility Project was chartered in 1991, by the Department of Energy to provide treatment capability for these mixed and low-level waste streams. The first project task consisted of conducting engineering studies to identify the waste streams, their potential treatment strategies, and the requirements that would be imposed on the waste streams and the facilities used to process them. This report, Appendix A, Environmental Regulatory Planning Documentation, identifies the regulatory requirements that would be imposed on the operation or construction of a facility designed to process the INEL's waste streams. These requirements are contained in five reports that discuss the following topics: (1) an environmental compliance plan and schedule, (2) National Environmental Policy Act requirements, (3) preliminary siting requirements, (4) regulatory justification for the project, and (5) health and safety criteria.

  16. Extrusion-mixing compared with hand-mixing of polyether impression materials?

    PubMed

    McMahon, Caroline; Kinsella, Daniel; Fleming, Garry J P

    2010-12-01

    The hypotheses tested were two-fold (a) whether altering the base:catalyst ratio influences working time, elastic recovery and strain in compression properties of a hand-mixed polyether impression material and (b) whether an extrusion-mixed polyether impression material would have a significant advantage over a hand-mixed polyether impression material mixed to the optimum base:catalyst ratio. The polyether was hand-mixed at the optimum (manufacturers recommended) base:catalyst ratios (7:1) and further groups were made by increasing or decreasing the catalyst length by 25%. Additionally specimens were also made from an extrusion-mixed polyether impression material and compared with the optimum hand-mixed base:catalyst ratio. A penetrometer assembly was used to measure the working time (n=5). Five cylindrical specimens for each hand-mixed and extrusion mixed group investigated were employed for elastic recovery and strain in compression testing. Hand-mixing polyether impression materials with 25% more catalyst than that recommended significantly decreased the working time while hand-mixing with 25% less catalyst than that recommended significantly increased the strain in compression. The extrusion-mixed polyether impression material provided similar working time, elastic recovery and strain in compression to the hand-mixed polyether mixed at the optimum base:catalyst ratio.

  17. Investigation on flow and mixing characteristics of supersonic mixing layer induced by forced vibration of cantilever

    NASA Astrophysics Data System (ADS)

    Zhang, Dongdong; Tan, Jianguo; Lv, Liang

    2015-12-01

    The mixing process has been an important issue for the design of supersonic combustion ramjet engine, and the mixing efficiency plays a crucial role in the improvement of the combustion efficiency. In the present study, nanoparticle-based planar laser scattering (NPLS), particle image velocimetry (PIV) and large eddy simulation (LES) are employed to investigate the flow and mixing characteristics of supersonic mixing layer under different forced vibration conditions. The indexes of fractal dimension, mixing layer thickness, momentum thickness and scalar mixing level are applied to describe the mixing process. Results show that different from the development and evolution of supersonic mixing layer without vibration, the flow under forced vibration is more likely to present the characteristics of three-dimensionality. The laminar flow region of mixing layer under forced vibration is greatly shortened and the scales of rolled up Kelvin-Helmholtz vortices become larger, which promote the mixing process remarkably. The fractal dimension distribution reveals that comparing with the flow without vibration, the turbulent fluctuation of supersonic mixing layer under forced vibration is more intense. Besides, the distribution of mixing layer thickness, momentum thickness and scalar mixing level are strongly influenced by forced vibration. Especially, when the forcing frequency is 4000 Hz, the mixing layer thickness and momentum thickness are 0.0391 m and 0.0222 m at the far field of 0.16 m, 83% and 131% higher than that without vibration at the same position, respectively.

  18. Selecting water-alcohol mixed solvent for synthesis of polydopamine nano-spheres using solubility parameter

    PubMed Central

    Jiang, Xiaoli; Wang, Yinling; Li, Maoguo

    2014-01-01

    The solvent plays an important role in a given chemical reaction. Since most reaction in nature occur in the mixed-solvent systems, a comprehensive principle for solvent optimization was required. By calculating the Hansen solubility parameters (HSP) distance Ra, we designed a model experiment to explore the influence of mixed solvents on the chemical synthesis. The synthesis of polydopamine (PDA) in the water-alcohol system was chosen as model. As predicted, the well-dispersed PDA spheres were obtained in selected solvents with smaller Ra values: methanol/water, ethanol/water and 2-propanol/water. In addition, the mixed solvent with smaller Ravalues gave a higher conversion of dopamine. The strategy for mixed solvent selection is might be useful to choose optimal reaction media for efficient chemical synthesis. PMID:25317902

  19. Biofuels spills in surface waters - a laboratory investigation of mixing and interfacial dynamics

    NASA Astrophysics Data System (ADS)

    Wang, Xiaoxiang; Cotel, Aline

    2016-11-01

    There are increasing risks of spills of ethanol-based biofuels in aquatic environments, however the environmental impact of such accidents is poorly understood and no adequate mitigation strategies are in place today. The interaction of water and biofuels is a complex dynamical problem and we aim to quantify the physical processes involved in such dynamics. A solution of ethanol and glycol is used to represent a typical ethanol-based fuel. A small-scale Plexiglas tank has been designed to investigate the effect of natural conditions on the mixing of water and biofuels, e.g. slope angle, flow rate, wave amplitude and frequency in wind driven conditions. Our previous work showed that the existence of two distinct mixing regimes; a first turbulence-driven fast mixing regime and a second regime driven by interface instabilities. We investigate these mixing regimes under an extended range of physical parameters representing more natural configurations. Funded by NSF.

  20. Selecting water-alcohol mixed solvent for synthesis of polydopamine nano-spheres using solubility parameter

    NASA Astrophysics Data System (ADS)

    Jiang, Xiaoli; Wang, Yinling; Li, Maoguo

    2014-08-01

    The solvent plays an important role in a given chemical reaction. Since most reaction in nature occur in the mixed-solvent systems, a comprehensive principle for solvent optimization was required. By calculating the Hansen solubility parameters (HSP) distance Ra, we designed a model experiment to explore the influence of mixed solvents on the chemical synthesis. The synthesis of polydopamine (PDA) in the water-alcohol system was chosen as model. As predicted, the well-dispersed PDA spheres were obtained in selected solvents with smaller Ra values: methanol/water, ethanol/water and 2-propanol/water. In addition, the mixed solvent with smaller Ra values gave a higher conversion of dopamine. The strategy for mixed solvent selection is might be useful to choose optimal reaction media for efficient chemical synthesis.

  1. Selecting water-alcohol mixed solvent for synthesis of polydopamine nano-spheres using solubility parameter.

    PubMed

    Jiang, Xiaoli; Wang, Yinling; Li, Maoguo

    2014-08-14

    The solvent plays an important role in a given chemical reaction. Since most reaction in nature occur in the mixed-solvent systems, a comprehensive principle for solvent optimization was required. By calculating the Hansen solubility parameters (HSP) distance Ra, we designed a model experiment to explore the influence of mixed solvents on the chemical synthesis. The synthesis of polydopamine (PDA) in the water-alcohol system was chosen as model. As predicted, the well-dispersed PDA spheres were obtained in selected solvents with smaller Ra values: methanol/water, ethanol/water and 2-propanol/water. In addition, the mixed solvent with smaller Ra values gave a higher conversion of dopamine. The strategy for mixed solvent selection is might be useful to choose optimal reaction media for efficient chemical synthesis.

  2. Children's understanding and experience of mixed emotions.

    PubMed

    Larsen, Jeff T; To, Yen M; Fireman, Gary

    2007-02-01

    Though some models of emotion contend that happiness and sadness are mutually exclusive in experience, recent findings suggest that adults can feel happy and sad at the same time in emotionally complex situations. Other research has shown that children develop a better conceptual understanding of mixed emotions as they grow older, but no research has examined children's actual experience of mixed emotions. To examine developmental differences in the experience of mixed emotions, we showed children ages 5 to 12 scenes from an animated film that culminated with a father and daughter's bittersweet farewell. In subsequent interviews, older children were more likely than younger children to report experiencing mixed emotions. These results suggest that in addition to having a better conceptual understanding of mixed emotions, older children are more likely than younger children to actually experience mixed emotions in emotionally complex situations.

  3. Electrothermal blinking vortices for chaotic mixing

    NASA Astrophysics Data System (ADS)

    Loire, Sophie; Kauffmann, Paul; Gimenez, Paul; Meinhart, Carl; Mezic, Igor

    2012-11-01

    We present an experimental and theoretical study of electrothermal chaotic mixing using blinking of asymmetric 2D electrothermal vortices. Electrothermal flows are modelled with 2D finite element method using COMSOL software based on an enhanced electrothermal model. Velocities in top-view and side-view devices are measured by micro particle image velocimetry (μPIV). The experimentally reconstructed velocity profile shows a dramatic asymmetry between the two vortices, in good agreement with the FEM model. The separation line between the two vortices is shifted and tilted making the blinking vortices overlap. We use the mix-variance coefficient (MVC) on experimental particle detection data and numerical trajectory simulations to evaluate mixing at different scales including the layering of fluid interfaces by the flow, a keypoint for efficient mixing. The blinking vortices method greatly improve mixing efficiency. Theoretical, experimental and simulation results of the mixing process will be presented.

  4. Mercury removal from solid mixed waste

    SciTech Connect

    Gates, D.D.; Morrissey, M.; Chava, K.K.; Chao, K.

    1994-12-31

    The removal of mercury from mixed wastes is an essential step in eliminating the temporary storage of large inventories of mixed waste throughout the Department of Energy (DOE) complex. Currently thermal treatment has been identified as a baseline technology and is being developed as part of the DOE Mixed Waste Integrated Program (MWIP). Since thermal treatment will not be applicable to all mercury containing mixed waste and the removal of mercury prior to thermal treatment may be desirable, laboratory studies have been initiated at Oak Ridge National Laboratory (ORNL) to develop alternative remediation technologies capable of removing mercury from certain mixed waste. This paper describes laboratory investigations of the KI/I{sub 2} leaching processes to determine the applicability of this process to mercury containing solid mixed waste.

  5. Droplet mixers: Microfluidics, mixing measures and optimization

    NASA Astrophysics Data System (ADS)

    Stone, Zachary; Stone, Howard

    2003-11-01

    Rapid mixing is essential in a variety of microfluidic applications but is often difficult to achieve at low Reynolds numbers. Inspired by a recently developed microdevice that mixes reagents in droplets, which simply flow along a periodic serpentine channel (Song, Tice and Ismagilov, 2003), we investigate a model ``droplet mixer". The model consists of a spherical droplet immersed in a periodic sequence of distinct external flows, which are superpositions of uniform and shear flows. We label the fluid inside the droplet with two colors and visualize mixing with a method we call ``backtrace imaging", which allows us to render cross-sections of the droplet at arbitrary times during the mixing cycle. To analyze our results, we present a simple measure of mixing, which allows us to locate sets of parameters that optimize mixing over a small number of flow cycles. We also consider shear flows in multiple directions and the effect of random variations in the durations of external flows.

  6. Mixed Modeling of Meta-Analysis P-Values (MixMAP) Suggests Multiple Novel Gene Loci for Low Density Lipoprotein Cholesterol

    PubMed Central

    Foulkes, Andrea S.; Matthews, Gregory J.; Das, Ujjwal; Ferguson, Jane F.; Lin, Rongheng; Reilly, Muredach P.

    2013-01-01

    Informing missing heritability for complex disease will likely require leveraging information across multiple SNPs within a gene region simultaneously to characterize gene and locus-level contributions to disease phenotypes. To this aim, we introduce a novel strategy, termed Mixed modeling of Meta-Analysis P-values (MixMAP), that draws on a principled statistical modeling framework and the vast array of summary data now available from genetic association studies, to test formally for locus level association. The primary inputs to this approach are: (a) single SNP level p-values for tests of association; and (b) the mapping of SNPs to genomic regions. The output of MixMAP is comprised of locus level estimates and tests of association. In application of MixMAP to summary data from the Global Lipids Gene Consortium, we suggest twelve new loci (PKN, FN1, UGT1A1, PPARG, DMDGH, PPARD, CDK6, VPS13B, GAD2, GAB2, APOH and NPC1) for low-density lipoprotein cholesterol (LDL-C), a causal risk factor for cardiovascular disease and we also demonstrate the potential utility of MixMAP in small data settings. Overall, MixMAP offers novel and complementary information as compared to SNP-based analysis approaches and is straightforward to implement with existing open-source statistical software tools. PMID:23405096

  7. PROCEEDINGS: 1993 SO2 CONTROL SYMPOSIUM - VOLUME 3. SESSIONS 5B, 6A, AND 6B

    EPA Science Inventory

    The report documents more than 100 presentations at the 1993 SO2 Control Symposium in Boston, MA, August 24-27, 1993. The presentations covered a wide range of topics: industry's strategies for dealing with Clean Air Act Amendments of 1990, including Phase I strategies, the emiss...

  8. Cowles Dissolver Fire Involving IR Flare Mix

    DTIC Science & Technology

    1994-08-01

    fluoroethylene (PTFE), and a fluoroelastomer binder dissolved in acetone. Hexane is used to precipitate the binder and wash the mix. During the wash...ethylene (PTFE), and a fluoroelastomer binder. The fluoroelastomer binder is dissolved in acetone before the mix is made. The PTFE and magnesium...the binder precipitates on the surface of the suspended particles. The solids are allowed to settle and the liquid is siphoned from the mix bowl

  9. Mechanisms of tolerance induced via mixed chimerism.

    PubMed

    Sykes, Megan

    2007-05-01

    Mixed hematopoietic chimerism provides a powerful means of inducing robust, donor-specific tolerance. In this article, the minimal requirements for achieving mixed chimerism, the development of new reagents that promote its achievement, and the mechanisms by which peripheral and intrathymic tolerance are achieved via mixed chimerism are discussed. An emerging understanding of these mechanisms, along with the development of new immunosuppressive reagents, is allowing advancement toward clinical application of this approach.

  10. Quantifying uncertainty in stable isotope mixing models

    SciTech Connect

    Davis, Paul; Syme, James; Heikoop, Jeffrey; Fessenden-Rahn, Julianna; Perkins, George; Newman, Brent; Chrystal, Abbey E.; Hagerty, Shannon B.

    2015-05-19

    Mixing models are powerful tools for identifying biogeochemical sources and determining mixing fractions in a sample. However, identification of actual source contributors is often not simple, and source compositions typically vary or even overlap, significantly increasing model uncertainty in calculated mixing fractions. This study compares three probabilistic methods, SIAR [Parnell et al., 2010] a pure Monte Carlo technique (PMC), and Stable Isotope Reference Source (SIRS) mixing model, a new technique that estimates mixing in systems with more than three sources and/or uncertain source compositions. In this paper, we use nitrate stable isotope examples (δ15N and δ18O) but all methods tested are applicable to other tracers. In Phase I of a three-phase blind test, we compared methods for a set of six-source nitrate problems. PMC was unable to find solutions for two of the target water samples. The Bayesian method, SIAR, experienced anchoring problems, and SIRS calculated mixing fractions that most closely approximated the known mixing fractions. For that reason, SIRS was the only approach used in the next phase of testing. In Phase II, the problem was broadened where any subset of the six sources could be a possible solution to the mixing problem. Results showed a high rate of Type I errors where solutions included sources that were not contributing to the sample. In Phase III some sources were eliminated based on assumed site knowledge and assumed nitrate concentrations, substantially reduced mixing fraction uncertainties and lowered the Type I error rate. These results demonstrate that valuable insights into stable isotope mixing problems result from probabilistic mixing model approaches like SIRS. The results also emphasize the importance of identifying a minimal set of potential sources and quantifying uncertainties in source isotopic composition as well as demonstrating the value of additional information in reducing the

  11. Quantifying uncertainty in stable isotope mixing models

    DOE PAGES

    Davis, Paul; Syme, James; Heikoop, Jeffrey; ...

    2015-05-19

    Mixing models are powerful tools for identifying biogeochemical sources and determining mixing fractions in a sample. However, identification of actual source contributors is often not simple, and source compositions typically vary or even overlap, significantly increasing model uncertainty in calculated mixing fractions. This study compares three probabilistic methods, SIAR [Parnell et al., 2010] a pure Monte Carlo technique (PMC), and Stable Isotope Reference Source (SIRS) mixing model, a new technique that estimates mixing in systems with more than three sources and/or uncertain source compositions. In this paper, we use nitrate stable isotope examples (δ15N and δ18O) but all methods testedmore » are applicable to other tracers. In Phase I of a three-phase blind test, we compared methods for a set of six-source nitrate problems. PMC was unable to find solutions for two of the target water samples. The Bayesian method, SIAR, experienced anchoring problems, and SIRS calculated mixing fractions that most closely approximated the known mixing fractions. For that reason, SIRS was the only approach used in the next phase of testing. In Phase II, the problem was broadened where any subset of the six sources could be a possible solution to the mixing problem. Results showed a high rate of Type I errors where solutions included sources that were not contributing to the sample. In Phase III some sources were eliminated based on assumed site knowledge and assumed nitrate concentrations, substantially reduced mixing fraction uncertainties and lowered the Type I error rate. These results demonstrate that valuable insights into stable isotope mixing problems result from probabilistic mixing model approaches like SIRS. The results also emphasize the importance of identifying a minimal set of potential sources and quantifying uncertainties in source isotopic composition as well as demonstrating the value of additional information in reducing the uncertainty in calculated

  12. Quantifying uncertainty in stable isotope mixing models

    NASA Astrophysics Data System (ADS)

    Davis, Paul; Syme, James; Heikoop, Jeffrey; Fessenden-Rahn, Julianna; Perkins, George; Newman, Brent; Chrystal, Abbey E.; Hagerty, Shannon B.

    2015-05-01

    Mixing models are powerful tools for identifying biogeochemical sources and determining mixing fractions in a sample. However, identification of actual source contributors is often not simple, and source compositions typically vary or even overlap, significantly increasing model uncertainty in calculated mixing fractions. This study compares three probabilistic methods, Stable Isotope Analysis in R (SIAR), a pure Monte Carlo technique (PMC), and Stable Isotope Reference Source (SIRS) mixing model, a new technique that estimates mixing in systems with more than three sources and/or uncertain source compositions. In this paper, we use nitrate stable isotope examples (δ15N and δ18O) but all methods tested are applicable to other tracers. In Phase I of a three-phase blind test, we compared methods for a set of six-source nitrate problems. PMC was unable to find solutions for two of the target water samples. The Bayesian method, SIAR, experienced anchoring problems, and SIRS calculated mixing fractions that most closely approximated the known mixing fractions. For that reason, SIRS was the only approach used in the next phase of testing. In Phase II, the problem was broadened where any subset of the six sources could be a possible solution to the mixing problem. Results showed a high rate of Type I errors where solutions included sources that were not contributing to the sample. In Phase III some sources were eliminated based on assumed site knowledge and assumed nitrate concentrations, substantially reduced mixing fraction uncertainties and lowered the Type I error rate. These results demonstrate that valuable insights into stable isotope mixing problems result from probabilistic mixing model approaches like SIRS. The results also emphasize the importance of identifying a minimal set of potential sources and quantifying uncertainties in source isotopic composition as well as demonstrating the value of additional information in reducing the uncertainty in calculated

  13. Complete Genome Sequence of Nitrosomonas ureae Strain Nm10, an Oligotrophic Group 6a Nitrosomonad

    PubMed Central

    Kozlowski, Jessica A.; Kits, K. Dimitri

    2016-01-01

    The complete genome of Nitrosomonas ureae strain Nm10, a mesophilic betaproteobacterial ammonia oxidizer isolated from Mediterranean soils in Sardinia, Italy, is reported here. This genome represents a cluster 6a nitrosomonad. PMID:26966201

  14. Finite element modeling of the higher harmonic controlled OH-6A helicopter airframe

    NASA Technical Reports Server (NTRS)

    Ferg, Douglas; Toossi, Mostafa

    1990-01-01

    An MSC/NASTRAN finite element model of the higher harmonic control configured OH-6A helicopter fuselage was developed. This finite element model was verified by performing various model checkouts and correlation with results from a ground vibration test.

  15. 20. Photocopy of Drawing No. 6A3249, 16 December 1914 (Original ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. Photocopy of Drawing No. 6A32-49, 16 December 1914 (Original held by Detroit Edison Company, Detroit, Michigan) CROSS SECTIONS JJ & KK - Detroit Edison Hart Substation, 11736 East Vernor, Detroit, MI

  16. Competitive marketing strategies. A challenge for academic practices.

    PubMed

    Sinioris, M E

    1985-01-01

    A special challenge has been presented to academic medical practices by the new healthcare environment. While increased competition for patients and resources affects all medical groups, it is the academic practices who are responsible for training the physicians of tomorrow. Not only must they sharpen their students' awareness of the new environment and teach them to incorporate effective management strategies into their practices, but they must set an example in effective management as well. The basic concepts of competitive marketing strategy, along with helpful exhibits, are presented here, and strategies for effectively maximizing position are discussed from the viewpoints of product mix, process market, and financing.

  17. An Introduction to LANL Mixed Potential Sensors

    SciTech Connect

    Mukundan, Rangachary; Brosha, Eric Lanich; Kreller, Cortney

    2015-01-26

    These are slides for a webinar given on the topics of an introduction to LANL mixed potential sensors. Topics include the history of LANL electrochemical sensor work, an introduction to mixed potential sensors, LANL uniqueness, and an application of LANL mixed potential sensors. The summary is as follows: Improved understanding of the mixed-potential sensor mechanism (factors controlling the sensor response identified), sensor design optimized to maximize sensor sensitivity and durability (porous electrolyte/dense electrodes), electrodes selected for various specific applications (CO, HC, H2), sensor operating parameters optimized for improved gas selectivity (NOx, NH3).

  18. TANK MIXING STUDY WITH FLOW RECIRCULATION

    SciTech Connect

    Lee, S.

    2014-06-25

    The primary objective of this work is to quantify the mixing time when two miscible fluids are mixed by one recirculation pump and to evaluate adequacy of 2.5 hours of pump recirculation to be considered well mixed in SRS tanks, JT-71/72. The work scope described here consists of two modeling analyses. They are the steady state flow pattern analysis during pump recirculation operation of the tank liquid and transient species transport calculations based on the initial steady state flow patterns. The modeling calculations for the mixing time are performed by using the 99% homogeneity criterion for the entire domain of the tank contents.

  19. Genome sequence of Bacillus sp. CHD6a, isolated from the shallow-sea hydrothermal vent.

    PubMed

    Lin, Wenxin; Chen, Hong; Chen, Qi; Liu, Yanting; Jiao, Nianzhi; Zheng, Qiang

    2016-02-01

    Bacillus sp. CHD6a, which can produce oval endosperms, isolated from the shallow-sea hydrothermal vent systems off northeast Taiwan's coast. Here, we report the draft genome sequence of Bacillus sp. CHD6a. It comprises ~3.97 Mb in 55 contigs with the G+C content of 39.9%, and a total of 3740 protein-coding genes were obtained.

  20. First report of an outbreak of pneumonia caused by Streptococcus pneumoniae serotype 6A.

    PubMed

    Prebil, Karla; Beović, Bojana; Paragi, Metka; Seme, Katja; Kastrin, Tamara; Plesničar, Blanka Kores; Petek, Bojana; Martinčič, Žiga

    2016-01-01

    Five patients in a geropsychiatric unit of a psychiatric hospital became abruptly ill with pneumonia caused by Streptococcus pneumoniae serotype 6A. Four other residents were colonized with the same serotype, which has previously not been reported in association with pneumonia outbreaks. Furthermore, serotype 6A is not included in all vaccine types, which may be important for the choice of vaccine in some settings. All isolates showed identical pulsed-field gel electrophoresis restriction patterns.

  1. Presence of HHV-6A in Endometrial Epithelial Cells from Women with Primary Unexplained Infertility

    PubMed Central

    Bortolotti, Daria; Lo Monte, Giuseppe; Caselli, Elisabetta; Bolzani, Silvia; Rotola, Antonella; Di Luca, Dario; Rizzo, Roberta

    2016-01-01

    To elucidate the roles of human herpesvirus (HHV)-6 primary unexplained infertile women, a prospective randomized study was conducted on a cohort of primary unexplained infertile women and a cohort of control women, with at least one successful pregnancy. HHV-6 DNA was analyzed and the percentage and immune-phenotype of resident endometrial Natural Killer (NK) cells, as the first line of defense towards viral infections, was evaluated in endometrial biopsies. Cytokine levels in uterine flushing samples were analyzed. HHV-6A DNA was found in 43% of endometrial biopsies from primary unexplained infertile women, but not in control women. On the contrary, HHV-6B DNA was absent in endometrial biopsies, but present in PBMCs of both cohorts. Endometrial NK cells presented a different distribution in infertile women with HHV6-A infection compared with infertile women without HHV6-A infection. Notably, we observed a lower percentage of endometrial specific CD56brightCD16- NK cells. We observed an enhanced HHV-6A-specific endometrial NK cell response in HHV-6A positive infertile women, with a marked increase in the number of endometrial NK cells activating towards HHV-6A infected cells. The analysis of uterine flushing samples showed an increase in IL-10 levels and a decrease of IFN-gamma concentrations in infertile women with HHV6-A infection. Our study indicates, for the first time, that HHV-6A infection might be an important factor in female unexplained infertility development, with a possible role in modifying endometrial NK cells immune profile and ability to sustain a successful pregnancy. PMID:27367597

  2. [Cooperation of mixed culturing bacteria in the hydrogen production by fermentation].

    PubMed

    Lin, Ming; Ren, Nanqi; Wang, Aijie; Wang, Xiangjing

    2003-03-01

    In order to discuss the cooperation of H2-producing fermentation bacteria (HPFB) in mixed culture, a batch test fed with glucose and complex organic substance (starch, beef, PEP and peptone) respectively, was conducted to investigate the effects of mixed culture on H2-producing ability. For the systemic and accurate analysis, three kinds of the mixed culture were use to this batch test. It included that the mixed culture with five strains of HPFB (B49, H1, LM12, LM11 and B51), B49 and three stains of non-HPFB (L10, Bacteroide 3-2, Sporobacterl), and B49 and hydrogen producing sludge. The results showed that the cooperation of mixed culturing bacteria was conditional on the substrates. When fed with glucose, which were easily utilized by HPB, the H2-producing ability of HPB was restrained because of the competition on the co-substrate between HPB and other fermentation bacteria, and it was quite difficult for the cooperation of mixed culturing bacteria to be performed. When fed with complex organic substance, the H2-producing ability of HPB was enhanced via the cooperation of mixed culturing bacteria. Furthermore, a strategy was put forward, that is, different kind of HPB cultures could be adopted according to the difference of substrates.

  3. A new method to manipulate broiler chicken growth and metabolism: Response to mixed LED light system

    NASA Astrophysics Data System (ADS)

    Yang, Yefeng; Yu, Yonghua; Pan, Jinming; Ying, Yibin; Zhou, Hong

    2016-05-01

    Present study introduced a new method to manipulate broiler chicken growth and metabolism by mixing the growth-advantage LED. We found that the green/blue LED mixed light system (G-B and G × B) have the similar stimulatory effect on chick body weight with single green light and single blue light (G and B), compared with normal artificial light (P = 0.028). Moreover, the percentage of carcass was significantly greater in the mixed light (G × B) when compared with the single light (P = 0.003). Synchronized with body weight, the mixed light (G-B and G × B) had a significant improved influence on the feed conversion of birds compared with normal light (P = 0.002). A significant improvement in feed conversion were found in mixed light (G × B) compared with single LED light (P = 0.037). G group resulted in a greater high-density lipoprotein cholesterol level than B group (P = 0.002), whereas B group resulted in a greater low-density lipoprotein cholesterol level than G group (P = 0.017). The mixed light significantly increased the birds’ glucose level in comparison with the single light (P = 0.003). This study might establish an effective strategy for maximizing growth of chickens by mixed LED technology.

  4. A role of Sema6A expressed in oligodendrocyte precursor cells.

    PubMed

    Okada, Atsumasa; Tomooka, Yasuhiro

    2013-02-28

    Our previous study has confirmed that the distribution of oligodendrocyte precursor cells (OPCs) is disturbed in the embryonic cerebral cortex of Plexin-A4 knockout mice, and that Sema6A is expressed in OPCs in the region. The present study examined whether Sema6A expressed in OPCs is involved in their own migration, and used a clonal FBD-102b line as OPCs model. In an in vitro migration assay, Sema6A knockdown repressed the migration of FBD-102b cells. Additionally, in co-culture, 3T3 cells ectopically expressing Plexin-A4 were segregated from 3T3 cells ectopically expressing Sema6A. When FBD-102b cells were seeded in a spot and exposed to a gradient of both Sema3A and Sema6A, dispersion of FBD-102b cells was suppressed, and Plexin-A4 knockdown in FBD-102b cells attenuated the suppressive effect of the Semaphorins. These results indicate that Sema6A expressed in OPCs is involved in their autonomous migration through ligand-receptor interaction with Plexin-A4 expressed in surrounding cells.

  5. Dominant Mutations in KAT6A Cause Intellectual Disability with Recognizable Syndromic Features

    PubMed Central

    Tham, Emma; Lindstrand, Anna; Santani, Avni; Malmgren, Helena; Nesbitt, Addie; Dubbs, Holly A.; Zackai, Elaine H.; Parker, Michael J.; Millan, Francisca; Rosenbaum, Kenneth; Wilson, Golder N.; Nordgren, Ann

    2015-01-01

    Through a multi-center collaboration study, we here report six individuals from five unrelated families, with mutations in KAT6A/MOZ detected by whole-exome sequencing. All five different de novo heterozygous truncating mutations were located in the C-terminal transactivation domain of KAT6A: NM_001099412.1: c.3116_3117 delCT, p.(Ser1039∗); c.3830_3831insTT, p.(Arg1278Serfs∗17); c.3879 dupA, p.(Glu1294Argfs∗19); c.4108G>T p.(Glu1370∗) and c.4292 dupT, p.(Leu1431Phefs∗8). An additional subject with a 0.23 MB microdeletion including the entire KAT6A reading frame was identified with genome-wide array comparative genomic hybridization. Finally, by detailed clinical characterization we provide evidence that heterozygous mutations in KAT6A cause a distinct intellectual disability syndrome. The common phenotype includes hypotonia, intellectual disability, early feeding and oromotor difficulties, microcephaly and/or craniosynostosis, and cardiac defects in combination with subtle facial features such as bitemporal narrowing, broad nasal tip, thin upper lip, posteriorly rotated or low-set ears, and microretrognathia. The identification of human subjects complements previous work from mice and zebrafish where knockouts of Kat6a/kat6a lead to developmental defects. PMID:25728777

  6. System Review about Function Role of ESCC Driver Gene KDM6A by Network Biology Approach.

    PubMed

    Ran, Jihua; Li, Hui; Li, Huiwu

    2016-01-01

    Background. KDM6A (Lysine (K)-Specific Demethylase 6A) is the driver gene related to esophageal squamous cell carcinoma (ESCC). In order to provide more biological insights into KDM6A, in this paper, we treat PPI (protein-protein interaction) network derived from KDM6A as a conceptual framework and follow it to review its biological function. Method. We constructed a PPI network with Cytoscape software and performed clustering of network with Clust&See. Then, we evaluate the pathways, which are statistically involved in the network derived from KDM6A. Lastly, gene ontology analysis of clusters of genes in the network was conducted. Result. The network includes three clusters that consist of 74 nodes connected via 453 edges. Fifty-five pathways are statistically involved in the network and most of them are functionally related to the processes of cell cycle, gene expression, and carcinogenesis. The biology themes of clusters 1, 2, and 3 are chromatin modification, regulation of gene expression by transcription factor complex, and control of cell cycle, respectively. Conclusion. The PPI network presents a panoramic view which can facilitate for us to understand the function role of KDM6A. It is a helpful way by network approach to perform system review on a certain gene.

  7. Treatment of mixed waste coolant

    SciTech Connect

    Kidd, S.; Bowers, J.S.

    1995-02-01

    The primary processes used at Lawrence Livermore National Laboratory (LLNL) for treatment of radioactively contaminated machine coolants are industrial waste treatment and in situ carbon adsorption. These two processes simplify approaches to meeting the sanitary sewer discharge limits and subsequent Land Disposal Restriction criteria for hazardous and mixed wastes (40 CFR 268). Several relatively simple technologies are used in industrial water treatment. These technologies are considered Best Demonstrated Available Technologies, or BDAT, by the Environmental Protection Agency. The machine coolants are primarily aqueous and contain water soluble oil consisting of ethanol amine emulsifiers derived from fatty acids, both synthetic and natural. This emulsion carries away metal turnings from a part being machined on a lathe or other machining tool. When the coolant becomes spent, it contains chlorosolvents carried over from other cutting operations as well as a fair amount of tramp oil from machine bearings. This results in a multiphasic aqueous waste that requires treatment of metal and organic contaminants. During treatment, any dissolved metals are oxidized with hydrogen peroxide. Once oxidized, these metals are flocculated with ferric sulfate and precipitated with sodium hydroxide, and then the precipitate is filtered through diatomaceous earth. The emulsion is broken up by acidifying the coolant. Solvents and oils are adsorbed using powdered carbon. This carbon is easily separated from the remaining coolant by vacuum filtration.

  8. First principles nonequilibrium plasma mixing

    NASA Astrophysics Data System (ADS)

    Ticknor, C.; Herring, S. D.; Lambert, F.; Collins, L. A.; Kress, J. D.

    2014-01-01

    We have performed nonequilibrium classical and quantum-mechanical molecular dynamics simulations that follow the interpenetration of deuterium-tritium (DT) and carbon (C) components through an interface initially in hydrostatic and thermal equilibrium. We concentrate on the warm, dense matter regime with initial densities of 2.5-5.5 g/cm3 and temperatures from 10 to 100 eV. The classical treatment employs a Yukawa pair-potential with the parameters adjusted to the plasma conditions, and the quantum treatment rests on an orbital-free density functional theory at the Thomas-Fermi-Dirac level. For times greater than about a picosecond, the component concentrations evolve in accordance with Fick's law for a classically diffusing fluid with the motion, though, described by the mutual diffusion coefficient of the mixed system rather than the self-diffusion of the individual components. For shorter times, microscopic processes control the clearly non-Fickian dynamics and require a detailed representation of the electron probability density in space and time.

  9. Mixed-species associations in cuxiús (genus Chiropotes).

    PubMed

    Shaffer, Christopher A; Barnett, Adrian A; Gregory, Tremaine; de Melo, Fabiano; Moreira, Leandro; Alvim, Thiago H G; Moura, Viviane S; Filó, Anderson; Cardoso, Tatiane; Port-Carvalho, Marcio; Santos, Ricardo Rodrigues dos; Boyle, Sarah A

    2016-05-01

    Polyspecific or mixed-species associations, where two or more species come together to forage and travel as a unit, have been reported in many primate species. These associations appear to offer a number of benefits to the species involved including increased foraging efficiency and decreased risk of predation. While several researchers have suggested that cuxiús (genus Chiropotes) form mixed-species associations, previous studies have not identified the circumstances under which cuxiús form associations or whether they form associations more often than would be expected by chance. Here we present data on the formation of mixed-species associations by four species of cuxiús at eight different sites in Brazil, Suriname, and Guyana. We analyzed data from two of the study sites, (Biological Dynamics of Forest Fragments Project (BDFFP), Brazil and the Upper Essequibo Conservation Concession (UECC), Guyana, to assess whether associations occurred more than would be expected by chance encounters and identify the factors influencing their formation. Cuxiús showed a high degree of inter-site variation in the frequency of time spent in association (ranging from 2 to 26% of observation time) and duration of associations (mean duration from 22 min to 2.5 hr). Sapajus apella was the most common association partner at most sites. At BDFFP, cuxiús formed associations more frequently but not for longer duration than expected by chance. For much of the year at UECC, associations were not more frequent or longer than chance. However, during the dry season, cuxiús formed associations with S. apella significantly more often and for longer duration than predicted by chance. Cuxiús at UECC formed associations significantly more often when in smaller subgroups and when foraging for insects, and alarm called significantly less frequently during associations. We suggest cuxiús form mixed-species associations at some sites as an adaptive strategy to decrease predation risk and

  10. Morphological differences of the carotid body among C57/BL6 (B6), A/J, and CSS B6A1 mouse strains.

    PubMed

    Chai, Sam; Gillombardo, Carl B; Donovan, Lucas; Strohl, Kingman P

    2011-08-15

    The C57/BL6 (B6) mouse strain exhibits post-hypoxic frequency decline and periodic breathing, as well as greater amount of irregular breathing during rest in comparison to the A/J and to the B6a1, a chromosomal substitution strain whereby the A/J chromosome 1 is bred onto the B6 background (Han et al., 2002; Yamauchi et al., 2008a,b). The hypothesis was that morphological differences in the carotid body would associate with such trait variations. After confirming strain differences in post-hypoxic ventilatory behavior, histological examination (n=8 in each group) using hematoxylin and eosin (H&E) staining revealed equivalent, well-defined tissue structure at the bifurcation of the carotid arteries, an active secretory parenchyma (type I cells) from the supportive stromal tissue, and clustering of type I cells in all three strains. Tyrosine hydroxylase (TH) immunohistochemical staining revealed a typical organization of type I cells and neurovascular components into glomeruli in all three strains. Image analysis from 5 μm sections from each strain generated a series of cytological metrics. The percent carotid body composition of TH+ type I cells in the A/J, B6 and B6a1 was 20±4%, 39±3%, and 44±3%, respectively (p=0.00004). However, cellular organization in terms of density and ultrastructure in the B6a1 is more similar to the B6 than to the A/J. These findings indicate that genetic mechanisms that produce strain differences in ventilatory function do not associate with carotid body structure or tyrosine hydroxylase morphology, and that A/J chromosome 1 does not contribute much to B6 carotid body morphology.

  11. Hydrolytic stability of pneumococcal group 6 (type 6A and 6B) capsular polysaccharides.

    PubMed

    Zon, G; Szu, S C; Egan, W; Robbins, J D; Robbins, J B

    1982-07-01

    The hydrolyses of the immunologically cross-reactive and constitutionally isomeric group 6 pneumococcal polysaccharides, types 6A and 6B, were investigated by 31P nuclear magnetic resonance spectroscopy, gel filtration through Sepharose 4B, reducing-sugar analysis, and rocket immunoelectrophoresis. Phosphorus nuclear magnetic resonance spectroscopy showed that cleavage of the repeating-unit phosphodiester linkages at pH 10, 60 degrees C was considerably faster (greater than 10(3) ) for the type 6A than the type 6B polysaccharide. Under these reaction conditions, 31P nuclear magnetic resonance kinetic measurements showed that the Na+ form of the type 6A polysaccharide underwent phosphodiester-linkage hydrolysis two times slower than the corresponding Ca+2 form; a stoichiometrically excess amount of Ca+2 caused a 30-fold enhancement of the latter hydrolysis rate. The spectroscopic characterization of phosphorus-containing end groups resulting from hydrolysis of the type 6A polymer provided additional mechanistic information. Heating the type 6A and 6B polysaccharides at 56 degrees C for various times led to gel filtration coefficients of distribution (Kd values) which indicated that the type 6A material underwent size reductions considerably faster than did the type 6B antigen; these increased Kd values qualitatively correlated with the loss of immunochemical reactivity measured by rocket immunoelectrophoresis. The application of a statistical theory to the depolymerization of the type 6A and 6B polysaccharides was consistent with random bond cleavage, as evidenced by the calculated versus measured gel filtration patterns. Although the molecular changes causing the size reductions were not fully elaborated, it was established that the acetal linkages of the type 6A and 6B polysaccharides were comparatively resistant to hydrolysis and that depolymerization by hydrolysis of the phosphodiester linkage was a major factor only in the type 6A structure. It was concluded

  12. Hydrolytic stability of pneumococcal group 6 (type 6A and 6B) capsular polysaccharides.

    PubMed Central

    Zon, G; Szu, S C; Egan, W; Robbins, J D; Robbins, J B

    1982-01-01

    The hydrolyses of the immunologically cross-reactive and constitutionally isomeric group 6 pneumococcal polysaccharides, types 6A and 6B, were investigated by 31P nuclear magnetic resonance spectroscopy, gel filtration through Sepharose 4B, reducing-sugar analysis, and rocket immunoelectrophoresis. Phosphorus nuclear magnetic resonance spectroscopy showed that cleavage of the repeating-unit phosphodiester linkages at pH 10, 60 degrees C was considerably faster (greater than 10(3) ) for the type 6A than the type 6B polysaccharide. Under these reaction conditions, 31P nuclear magnetic resonance kinetic measurements showed that the Na+ form of the type 6A polysaccharide underwent phosphodiester-linkage hydrolysis two times slower than the corresponding Ca+2 form; a stoichiometrically excess amount of Ca+2 caused a 30-fold enhancement of the latter hydrolysis rate. The spectroscopic characterization of phosphorus-containing end groups resulting from hydrolysis of the type 6A polymer provided additional mechanistic information. Heating the type 6A and 6B polysaccharides at 56 degrees C for various times led to gel filtration coefficients of distribution (Kd values) which indicated that the type 6A material underwent size reductions considerably faster than did the type 6B antigen; these increased Kd values qualitatively correlated with the loss of immunochemical reactivity measured by rocket immunoelectrophoresis. The application of a statistical theory to the depolymerization of the type 6A and 6B polysaccharides was consistent with random bond cleavage, as evidenced by the calculated versus measured gel filtration patterns. Although the molecular changes causing the size reductions were not fully elaborated, it was established that the acetal linkages of the type 6A and 6B polysaccharides were comparatively resistant to hydrolysis and that depolymerization by hydrolysis of the phosphodiester linkage was a major factor only in the type 6A structure. It was concluded

  13. Intermittent search strategies

    NASA Astrophysics Data System (ADS)

    Bénichou, O.; Loverdo, C.; Moreau, M.; Voituriez, R.

    2011-01-01

    This review examines intermittent target search strategies, which combine phases of slow motion, allowing the searcher to detect the target, and phases of fast motion during which targets cannot be detected. It is first shown that intermittent search strategies are actually widely observed at various scales. At the macroscopic scale, this is, for example, the case of animals looking for food; at the microscopic scale, intermittent transport patterns are involved in a reaction pathway of DNA-binding proteins as well as in intracellular transport. Second, generic stochastic models are introduced, which show that intermittent strategies are efficient strategies that enable the minimization of search time. This suggests that the intrinsic efficiency of intermittent search strategies could justify their frequent observation in nature. Last, beyond these modeling aspects, it is proposed that intermittent strategies could also be used in a broader context to design and accelerate search processes.

  14. Cost-Effectiveness of Chagas Disease Vector Control Strategies in Northwestern Argentina

    PubMed Central

    Vazquez-Prokopec, Gonzalo M.; Spillmann, Cynthia; Zaidenberg, Mario; Kitron, Uriel; Gürtler, Ricardo E.

    2009-01-01

    Background Control and prevention of Chagas disease rely mostly on residual spraying of insecticides. In Argentina, vector control shifted from a vertical to a fully horizontal strategy based on community participation between 1992 and 2004. The effects of such strategy on Triatoma infestans, the main domestic vector, and on disease transmission have not been assessed. Methods and Findings Based on retrospective (1993–2004) records from the Argentinean Ministry of Health for the Moreno Department, Northwestern Argentina, we performed a cost-effectiveness (CE) analysis and compared the observed CE of the fully horizontal vector control strategy with the expected CE for a vertical or a mixed (i.e., vertical attack phase followed by horizontal surveillance) strategy. Total direct costs (in 2004 US$) of the horizontal and mixed strategies were, respectively, 3.3 and 1.7 times lower than the costs of the vertical strategy, due to reductions in personnel costs. The estimated CE ratios for the vertical, mixed and horizontal strategies were US$132, US$82 and US$45 per averted human case, respectively. When per diems were excluded from the costs (i.e., simulating the decentralization of control activities), the CE of vertical, mixed and horizontal strategies was reduced to US$60, US$42 and US$32 per averted case, respectively. Conclusions and Significance The mixed strategy would have averted between 1.6 and 4.0 times more human cases than the fully horizontal strategy, and would have been the most cost-effective option to interrupt parasite transmission in the Department. In rural and dispersed areas where waning vertical vector programs cannot accomplish full insecticide coverage, alternative strategies need to be developed. If properly implemented, community participation represents not only the most appealing but also the most cost-effective alternative to accomplish such objectives. PMID:19156190

  15. Inference of ICF implosion core mix using experimental data and theoretical mix modeling

    SciTech Connect

    Sherrill, Leslie Welser; Haynes, Donald A; Cooley, James H; Sherrill, Manolo E; Mancini, Roberto C; Tommasini, Riccardo; Golovkin, Igor E; Haan, Steven W

    2009-01-01

    The mixing between fuel and shell materials in Inertial Confinement Fusion (lCF) implosion cores is a current topic of interest. The goal of this work was to design direct-drive ICF experiments which have varying levels of mix, and subsequently to extract information on mixing directly from the experimental data using spectroscopic techniques. The experimental design was accomplished using hydrodynamic simulations in conjunction with Haan's saturation model, which was used to predict the mix levels of candidate experimental configurations. These theoretical predictions were then compared to the mixing information which was extracted from the experimental data, and it was found that Haan's mix model predicted trends in the width of the mix layer as a function of initial shell thickness. These results contribute to an assessment of the range of validity and predictive capability of the Haan saturation model, as well as increasing confidence in the methods used to extract mixing information from experimental data.

  16. Robotics Strategy White Paper

    DTIC Science & Technology

    2009-03-19

    VIRGINIA 23651-1087 REPlY TO A1Tl!NTlON OF ATFC-DS 19 MEMORANDUM FOR SEE DISTRIBUTION SUBJECT: Robotics Strategy White Paper 1. The enclosed... Robotics Strategy White Paper is the result of a collaborative effort between the U.S. Anny Training and Doctrine Command (TRADOC) and the Tank-Automotive...Research, Development and Engineering Center (TARDEC). This paper builds on a confederated Anny robotics "strategy" that is described by senior leader

  17. The GPRC6A Receptor displays Constitutive Internalization and Sorting to the Slow Recycling Pathway.

    PubMed

    Jacobsen, Stine Engesgaard; Ammendrup-Johnsen, Ina; Jansen, Anna Mai; Gether, Ulrik; Madsen, Kenneth Lindegaard; Bräuner-Osborne, Hans

    2017-03-09

    The class C G protein-coupled receptor GPRC6A is a putative nutrient sensing receptor and represents a possible new drug target in metabolic disorders. However, the specific physiological role of this receptor has yet to be identified, and the mechanisms regulating its activity and cell surface availability also remain enigmatic. In the present study, we investigated the trafficking properties of GPRC6A by use of both a classical antibody feeding internalization assay in which cells were visualized using confocal microscopy and a novel internalization assay that is based on real-time measurements of fluorescence resonance energy transfer. Both assays revealed that GPRC6A predominantly undergoes constitutive internalization while the agonist-induced effects were imperceptible. Moreover, post-endocytic sorting was investigated by assessing the co-localization of internalized GPRC6A with selected Rab protein markers. Internalized GPRC6A was mainly co-localized with the early endosome marker Rab5 and the long loop recycling endosome marker Rab11 and to a much lesser extent with the late endosome marker Rab7. This suggests that upon agonist-independent internalization, GPRC6A is recycled via the Rab11-positive slow recycling pathway, which may be responsible for ensuring a persistent pool of GPRC6A receptors at the cell surface despite chronic agonist exposure. Distinct trafficking pathways have been reported for several of the class C receptors, and our results thus substantiate that non-canonical trafficking mechanisms are a common feature for the nutrient sensing class C family that ensure functional receptors in the cell membrane despite prolonged agonist exposure.

  18. Cognitive Strategy in Learning Chemistry: How Chunking and Learning Get Together

    ERIC Educational Resources Information Center

    Lah, Norma Che; Saat, Rohaida Mohd; Hassan, Ruhaya

    2014-01-01

    The study explores chunking strategies applied in Short Term Memory (STM) by upper secondary students of mixed chemistry learning abilities. The aim of the study is to observe variations in chunking strategies utilized by these students when learning the Periodic Table of Elements in the Form Four Chemistry syllabus. Findings show that students…

  19. Age-Related Differences in Emotion Regulation Strategies: Examining the Role of Contextual Factors

    ERIC Educational Resources Information Center

    Schirda, Brittney; Valentine, Thomas R.; Aldao, Amelia; Prakash, Ruchika Shaurya

    2016-01-01

    Increasing age is characterized by greater positive affective states. However, there is mixed evidence on the implementation of emotion regulation strategies across the life span. To clarify the discrepancies in the literature, we examined the modulating influence of contextual factors in understanding emotion regulation strategy use in older and…

  20. Self-Regulated Strategies Chinese Graduate Students Employ to Learn English at Three American Universities

    ERIC Educational Resources Information Center

    Ma, Wen; Wang, Chuang

    2012-01-01

    International students in the United States often employ culture-specific learning strategies to help them improve their proficiency in English. This study explored the use of self-regulated strategies by 49 Chinese graduate students from 24 fields of study at three universities in the Northeast. The research used the mixed survey method to…

  1. Effect of Explicit Language Learning Strategy Instruction on Language-Test and Self-Assessment Scores

    ERIC Educational Resources Information Center

    Jurkovic, Violeta

    2010-01-01

    The present article reports on the findings of a study that explored the effect of explicit language learning strategy instruction on the development of English as a foreign language within a higher education setting in mixed language ability groups. The research results indicate that explicit language learning strategy instruction that aimed at…

  2. Adult Professional Development: Can Brain-Based Teaching Strategies Increase Learning Effectiveness?

    ERIC Educational Resources Information Center

    Tilton, Wendy

    2011-01-01

    Brain-based teaching strategies, compared to facilitative student-centered teaching strategies, were employed with 62 real estate professionals in a quasi-mixed-methods study. Participants attended a 2-day proprietary real estate continuing education course. Both the experimental and control groups received the same facilitative instruction, as…

  3. Assessing the Effects of Four Budget-Balancing Strategies in Higher Education

    ERIC Educational Resources Information Center

    Hauptman, Arthur M.; Nolan, Philip

    2011-01-01

    This paper compares four short- and medium-term strategies available to public higher education to balance budgets in the face of major cutbacks in public funding. These strategies include: capping enrolments, changing the enrolment mix, raising prices and increasing enrolments without raising prices. The paper assesses the likely effects of these…

  4. Strategies Pregnant Rural Women Employ to Deal with Intimate Partner Violence

    ERIC Educational Resources Information Center

    Bhandari, Shreya; Bullock, Linda F. C.; Sharps, Phyllis W.

    2013-01-01

    This study explored strategies from the Intimate Partner Violence Strategy Index (IPVSI) that a sub-set of 20 rural, low-income, abused women of a larger, multi-site, mixed-method study employed to deal with Intimate Partner Violence (IPV) during the perinatal period. We conducted 32 in-depth interviews with women who were pregnant (N = 12) and/or…

  5. Parrondo's games with strategy

    NASA Astrophysics Data System (ADS)

    Van den Broeck, Christian P.; Cleuren, Bart

    2004-05-01

    The notion of a strategy in the multi-player version of the Parrondo game is reviewed. We calculate the gain for the greedy strategy as a function of the number N of players, including exact analytic results for N < 4 and in the limit N-->∞. We show that the greedy strategy is optimal for N = 1 and N = 2 but not for N = 3. In the limit N-->∞ our analysis reveals a very rich behavior including the possibility of phase transitions as a function of the chosen strategy.

  6. No Association of BDNF, COMT, MAOA, SLC6A3, and SLC6A4 Genes and Depressive Symptoms in a Sample of Healthy Colombian Subjects

    PubMed Central

    González-Giraldo, Yeimy; Camargo, Andrés; López-León, Sandra; Forero, Diego A.

    2015-01-01

    Background. Major depressive disorder (MDD) is the second cause of years lived with disability around the world. A large number of studies have been carried out to identify genetic risk factors for MDD and related endophenotypes, mainly in populations of European and Asian descent, with conflicting results. The main aim of the current study was to analyze the possible association of five candidate genes and depressive symptoms in a Colombian sample of healthy subjects. Methods and Materials. The Spanish adaptation of the Hospital Anxiety and Depression Scale (HADS) was applied to one hundred eighty-eight healthy Colombian subjects. Five functional polymorphisms were genotyped using PCR-based assays: BDNF-Val66Met (rs6265), COMT-Val158Met (rs4680), SLC6A4-HTTLPR (rs4795541), MAOA-uVNTR, and SLC6A3-VNTR (rs28363170). Result. We did not find significant associations with scores of depressive symptoms, derived from the HADS, for any of the five candidate genes (nominal p values >0.05). In addition, we did not find evidence of significant gene-gene interactions. Conclusion. This work is one of the first studies of candidate genes for depressive symptoms in a Latin American sample. Study of additional genetic and epigenetic variants, taking into account other pathophysiological theories, will help to identify novel candidates for MDD in populations around the world. PMID:26557993

  7. No Association of BDNF, COMT, MAOA, SLC6A3, and SLC6A4 Genes and Depressive Symptoms in a Sample of Healthy Colombian Subjects.

    PubMed

    González-Giraldo, Yeimy; Camargo, Andrés; López-León, Sandra; Forero, Diego A

    2015-01-01

    Background. Major depressive disorder (MDD) is the second cause of years lived with disability around the world. A large number of studies have been carried out to identify genetic risk factors for MDD and related endophenotypes, mainly in populations of European and Asian descent, with conflicting results. The main aim of the current study was to analyze the possible association of five candidate genes and depressive symptoms in a Colombian sample of healthy subjects. Methods and Materials. The Spanish adaptation of the Hospital Anxiety and Depression Scale (HADS) was applied to one hundred eighty-eight healthy Colombian subjects. Five functional polymorphisms were genotyped using PCR-based assays: BDNF-Val66Met (rs6265), COMT-Val158Met (rs4680), SLC6A4-HTTLPR (rs4795541), MAOA-uVNTR, and SLC6A3-VNTR (rs28363170). Result. We did not find significant associations with scores of depressive symptoms, derived from the HADS, for any of the five candidate genes (nominal p values >0.05). In addition, we did not find evidence of significant gene-gene interactions. Conclusion. This work is one of the first studies of candidate genes for depressive symptoms in a Latin American sample. Study of additional genetic and epigenetic variants, taking into account other pathophysiological theories, will help to identify novel candidates for MDD in populations around the world.

  8. Critical Appraisal of Mixed Methods Studies

    ERIC Educational Resources Information Center

    Heyvaert, Mieke; Hannes, Karin; Maes, Bea; Onghena, Patrick

    2013-01-01

    In several subdomains of the social, behavioral, health, and human sciences, research questions are increasingly answered through mixed methods studies, combining qualitative and quantitative evidence and research elements. Accordingly, the importance of including those primary mixed methods research articles in systematic reviews grows. It is…

  9. Toponium-Z/sup 0/ mixing

    SciTech Connect

    Franzini, P.J.

    1986-11-01

    The subject of Z/sup 0/-toponium interference is briefly reviewed. The qualitative features of the Z/sup 0/ mixing with one t anti t state are discussed. Effects of mixing with the full t anti t spectrum, of the smearing due to beam spread, and of different potentials, are then shown.

  10. Discontinuous Mixed Covolume Methods for Parabolic Problems

    PubMed Central

    Zhu, Ailing

    2014-01-01

    We present the semidiscrete and the backward Euler fully discrete discontinuous mixed covolume schemes for parabolic problems on triangular meshes. We give the error analysis of the discontinuous mixed covolume schemes and obtain optimal order error estimates in discontinuous H(div) and first-order error estimate in L2. PMID:24983008

  11. Thin films of mixed metal compounds

    DOEpatents

    Mickelsen, Reid A.; Chen, Wen S.

    1985-01-01

    A compositionally uniform thin film of a mixed metal compound is formed by simultaneously evaporating a first metal compound and a second metal compound from independent sources. The mean free path between the vapor particles is reduced by a gas and the mixed vapors are deposited uniformly. The invention finds particular utility in forming thin film heterojunction solar cells.

  12. 7 CFR 51.576 - Mixed blanch.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946... Standards for Celery Definitions § 51.576 Mixed blanch. Mixed blanch consists of green and fairly...

  13. 7 CFR 51.576 - Mixed blanch.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946... Standards for Celery Definitions § 51.576 Mixed blanch. Mixed blanch consists of green and fairly...

  14. 7 CFR 51.576 - Mixed blanch.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946... Standards for Celery Definitions § 51.576 Mixed blanch. Mixed blanch consists of green and fairly...

  15. Mixed Methods, Triangulation, and Causal Explanation

    ERIC Educational Resources Information Center

    Howe, Kenneth R.

    2012-01-01

    This article distinguishes a disjunctive conception of mixed methods/triangulation, which brings different methods to bear on different questions, from a conjunctive conception, which brings different methods to bear on the same question. It then examines a more inclusive, holistic conception of mixed methods/triangulation that accommodates…

  16. Mixed Methods Research Designs in Counseling Psychology

    ERIC Educational Resources Information Center

    Hanson, William E.; Creswell, John W.; Clark, Vicki L. Plano; Petska, Kelly S.; Creswell, David J.

    2005-01-01

    With the increased popularity of qualitative research, researchers in counseling psychology are expanding their methodologies to include mixed methods designs. These designs involve the collection, analysis, and integration of quantitative and qualitative data in a single or multiphase study. This article presents an overview of mixed methods…

  17. Is There a School Mix Effect?

    ERIC Educational Resources Information Center

    Gorard, Stephen

    2006-01-01

    This paper uses the notion of "pathological" social science, wherein large claims to knowledge are made on the basis of very small differences in the data, to consider the notion of the school mix effect. It describes a variety of plausible alternative explanations for the same sets of findings, including the school mix effect, but also errors in…

  18. Neutrino mixing and oscillations in astrophysical environments

    SciTech Connect

    Balantekin, A. B.

    2014-05-02

    A brief review of the current status of neutrino mixing and oscillations in astrophysical environments, with particular emphasis on the Sun and core-collapse supernovae, is given. Implications of the existence of sterile states which mix with the active neutrinos are discussed.

  19. Mixing efficiency of turbulent stratified flows

    NASA Astrophysics Data System (ADS)

    White, B. L.; Scotti, A. D.

    2012-12-01

    Small-scale mixing in the stratified interior of the ocean is a fundamental, but poorly characterized, controlling factor of the global Meridional Overturning Circulation (MOC). The mixing efficiency in the ocean has typically been assumed to be 20%, which is used as a basis to estimate the required turbulent dissipation to support the ocean diapycnal buoyancy flux. In this talk, we use DNS datasets to calculate the mixing efficiency in different classes of stratified turbulent flows. In particular, we compare flows forced thermodynamically by production of Available Potential Energy (APE) at a boundary, such as horizontal convection (a simple model for an ocean forced by differential surface heating) and flows that are forced mechanically by surface stresses. The mixing efficiency is calculated based on the irreversible diapycnal flux of buoyancy (Winters and D'Asaro, 1996; Scotti et al., 2006) instead of the more customary turbulent buoyancy flux, thereby isolating mixing from reversible processes (e.g., internal waves). For mechanically-driven flows, profiles of mixing efficiency vs. buoyancy Reynolds number are in agreement with accepted values for stratified turbulent shear flows. However, for flows in which mixing is driven in part or fully by thermodynamic forcing and an excess of APE, DNS results show much higher values of the mixing efficiency, approaching unity for horizontal convection. Implications of these results for the energy budget of the MOC are discussed. Note: The DNS data sets of turbulent stratified channel flow are provided courtesy of M. Garcia-Villalba and J. C. del Alamo.

  20. 7 CFR 29.3532 - Mixed (M).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Mixed (M). 29.3532 Section 29.3532 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... Type 95) § 29.3532 Mixed (M). Variegated or distinctly different colors of the type mingled...

  1. 7 CFR 29.3532 - Mixed (M).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Mixed (M). 29.3532 Section 29.3532 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... Type 95) § 29.3532 Mixed (M). Variegated or distinctly different colors of the type mingled...

  2. Treatment of mixed features in bipolar disorder.

    PubMed

    Rosenblat, Joshua D; McIntyre, Roger S

    2016-09-13

    Mood episodes with Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5)-defined mixed features are highly prevalent in bipolar disorder (BD), affecting ~40% of patients during the course of illness. Mixed states are associated with poorer clinical outcomes, greater treatment resistance, higher rates of comorbidity, more frequent mood episodes, and increased rates of suicide. The objectives of the current review are to identify, summarize, and synthesize studies assessing the efficacy of treatments specifically for BD I and II mood episodes (ie, including manic, hypomanic, and major depressive episodes) with DSM-5-defined mixed features. Two randomized controlled trials (RCTs) and 6 post-hoc analyses were identified, all of which assessed the efficacy of second-generation antipsychotics (SGAs) for the acute treatment of BD mood episodes with mixed features. Results from these studies provide preliminary support for SGAs as efficacious treatments for both mania with mixed features and bipolar depression with mixed features. However, there are inadequate data to definitively support or refute the clinical use of specific agents. Conventional mood stabilizing agents (eg, lithium and divalproex) have yet to have been adequately studied in DSM-5-defined mixed features. Further study is required to assess the efficacy, safety, and tolerability of treatments specifically for BD mood episodes with mixed features.

  3. Tower Water-Vapor Mixing Ratio

    SciTech Connect

    Guastad, Krista; Riihimaki, Laura; none,

    2013-04-01

    The purpose of the Tower Water-Vapor Mixing Ratio (TWRMR) value-added product (VAP) is to calculate water-vapor mixing ratio at the 25-meter and 60-meter levels of the meteorological tower at the Southern Great Plains (SGP) Central Facility.

  4. Film processing investigation. [improved chemical mixing system

    NASA Technical Reports Server (NTRS)

    Kelly, J. L.

    1972-01-01

    The present operational chemical mixing system for the Photographic Technology Division is evaluated, and the limitations are defined in terms of meeting the present and programmed chemical supply and delivery requirements. A major redesign of the entire chemical mixing, storage, analysis, and supply system is recommended. Other requirements for immediate and future implementations are presented.

  5. Efficiency of Metal Mixing in Dwarf Galaxies

    NASA Astrophysics Data System (ADS)

    Hirai, Yutaka; Saitoh, Takayuki R.

    2017-04-01

    Metal mixing plays a critical role in the enrichment of metals in galaxies. The abundance of elements such as Mg, Fe, and Ba in metal-poor stars helps us understand the metal mixing in galaxies. However, the efficiency of metal mixing in galaxies is not yet understood. Here we report a series of N-body/smoothed particle hydrodynamics simulations of dwarf galaxies with different efficiencies of metal mixing using a turbulence-induced mixing model. We show that metal mixing apparently occurs in dwarf galaxies from Mg and Ba abundances. We find that a scaling factor for metal diffusion larger than 0.01 is necessary to reproduce the measured abundances of Ba in dwarf galaxies. This value is consistent with the value expected from turbulence theory and experiments. We also find that the timescale of metal mixing is less than 40 Myr. This timescale is shorter than the typical dynamical times of dwarf galaxies. We demonstrate that the determination of a degree of scatters of Ba abundance by the observation will help us to better constrain the efficiency of metal mixing.

  6. Mixed Methods Approaches in Family Science Research

    ERIC Educational Resources Information Center

    Plano Clark, Vicki L.; Huddleston-Casas, Catherine A.; Churchill, Susan L.; Green, Denise O'Neil; Garrett, Amanda L.

    2008-01-01

    The complex phenomena of interest to family scientists require the use of quantitative and qualitative approaches. Researchers across the social sciences are now turning to mixed methods designs that combine these two approaches. Mixed methods research has great promise for addressing family science topics, but only if researchers understand the…

  7. "Reading" Mixed Methods Research: Contexts for Criticism

    ERIC Educational Resources Information Center

    Freshwater, Dawn

    2007-01-01

    Health and social care researchers, in their haste to "belong" to academia, have adopted the system of mixed methodology research, overestimating its ability to reveal the truth and occasionally imprisoning their thought in one system. In this article, some of the assumptions underpinning mixed methodology research and its discourse are subjected…

  8. Physical properties of mixed dairy food proteins

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Mixed food protein gels are complex systems, which changes functional behaviors such as gelling properties and viscosity depending on the miscibility of the proteins. We have noted that differences in co-solubility of mixed proteins created unique network structures and gel properties. The effects o...

  9. Quark lepton universality and large leptonic mixing

    NASA Astrophysics Data System (ADS)

    Joshipura, Anjan S.; Smirnov, A. Yu.

    2006-08-01

    A unified description of fermionic mixing is proposed which assumes that in certain basis (i) a single complex unitary matrix V diagonalizes mass matrices of all fermions to the leading order, (ii) the SU(5) relation M=MlT exists between the mass matrices of the down quarks and the charged leptons, and (iii) Md†=M. These assumptions automatically lead to different mixing patterns for quarks and leptons: Quarks remain unmixed to leading order (i.e. V=1) while leptons have non-trivial mixing given by a symmetric unitary matrix VPMNS0=VV. V depends on two physical mixing angles and for values of these angles ˜20°-25° it reproduces the observed mixing patterns rather well. We identify conditions under which the universal mixing V follows from the universal mass matrices of fermions. Relatively small perturbations to the leading order structure lead to the CKM mixing and corrections to VPMNS0. We find that if the correction matrix equals the CKM matrix, the resulting lepton mixing agrees well with data and predicts ()e3>0.08.

  10. Flowmeter determines mix ratio for viscous adhesives

    NASA Technical Reports Server (NTRS)

    Lemons, C. R.

    1967-01-01

    Flowmeter determines mix ratio for continuous flow mixing machine used to produce an adhesive from a high viscosity resin and aliphatic amine hardener pumped through separate lines to a rotary blender. The flowmeter uses strain gages in the two flow paths and monitors their outputs with appropriate instrumentation.

  11. Milestone M4900: Simulant Mixing Analytical Results

    SciTech Connect

    Kaplan, D.I.

    2001-07-26

    This report addresses Milestone M4900, ''Simulant Mixing Sample Analysis Results,'' and contains the data generated during the ''Mixing of Process Heels, Process Solutions, and Recycle Streams: Small-Scale Simulant'' task. The Task Technical and Quality Assurance Plan for this task is BNF-003-98-0079A. A report with a narrative description and discussion of the data will be issued separately.

  12. The role of chemotherapy for pure and mixed anaplastic oligodendroglial tumors.

    PubMed

    Dunbar, Erin M

    2009-08-01

    Pure and mixed anaplastic oligodendrogliomas (AO/mixed-AOs) remain terminal primary brain tumors, without a defined optimal initial therapy, and without sufficiently active and tolerable therapies at recurrence/progression (R/P). Very heterogeneous international therapy recommendations remain. Historical advances have resulted in only modest improvements in outcome. AO/mixed-AOs with 1p/19q co-deletion are prognostically favorable, regardless of therapy, and must be identified as early as possible. Following resection, outcome data on initial therapy with radiation (RT) remain the most mature, although controversies regarding its true toxicities and optimal timing continue. Recently, the landmark RTOG 9402 and EORTC 26951 trials showed that the addition of Procarbazine, CCNU, Vincristine chemotherapy to RT, at anytime during initial therapy, prolongs progression-free survival, but not survival, and not without moderate toxicity. Despite a lack of definitive evidence, this strategy has commonly been extrapolated to Temozolomide. Chemo-sensitivity of AO/mixed-AOs provides the rationale for the chemotherapy-only strategies being explored. In the setting of recurrence/progression (R/P), chemotherapy, small molecule (targeted), biologic, and other strategies have been relatively disappointing, toxic, and cumbersome. Partly secondary to biases regarding the relative toxicities of tumor burden vs. treatment effect, therapy remains highly individualized. Future international research must prospectively evaluate health-related quality of life, toxicity, and molecular genetic markers.

  13. Stimulation of the amino acid transporter SLC6A19 by JAK2

    SciTech Connect

    Bhavsar, Shefalee K.; Hosseinzadeh, Zohreh; Merches, Katja; Gu, Shuchen; Broeer, Stefan; Lang, Florian

    2011-10-28

    Highlights: Black-Right-Pointing-Pointer The amino acid transporter SLC6A19 is upregulated by Janus kinase-2 JAK2. Black-Right-Pointing-Pointer The {sup V617F}JAK2 mutant, causing myeloproliferative disease, is more effective. Black-Right-Pointing-Pointer JAK2 inhibitor AG490 reverses stimulation of SLC6A19 by {sup V617F}JAK2. Black-Right-Pointing-Pointer JAK2 enhances SLC6A19 protein insertion into the cell membrane. Black-Right-Pointing-Pointer SLC6A19 may contribute to amino acid uptake into {sup V617F}JAK2 expressing tumor cells. -- Abstract: JAK2 (Janus kinase-2) is expressed in a wide variety of cells including tumor cells and contributes to the proliferation and survival of those cells. The gain of function mutation {sup V617F}JAK2 mutant is found in the majority of myeloproliferative diseases. Cell proliferation depends on the availability of amino acids. Concentrative cellular amino acid uptake is in part accomplished by Na{sup +} coupled amino acid transport through SLC6A19 (B(0)AT). The present study thus explored whether JAK2 activates SLC6A19. To this end, SLC6A19 was expressed in Xenopus oocytes with or without wild type JAK2, {sup V617F}JAK2 or inactive {sup K882E}JAK2 and electrogenic amino acid transport determined by dual electrode voltage clamp. In SLC6A19-expressing oocytes but not in oocytes injected with water or JAK2 alone, the addition of leucine (2 mM) to the bath generated a current (I{sub le}), which was significantly increased following coexpression of JAK2 or {sup V617F}JAK2, but not by coexpression of {sup K882E}JAK2. Coexpression of JAK2 enhanced the maximal transport rate without significantly modifying the affinity of the carrier. Exposure of the oocytes to the JAK2 inhibitor AG490 (40 {mu}M) resulted in a gradual decline of I{sub le}. According to chemiluminescence JAK2 enhanced the carrier protein abundance in the cell membrane. The decline of I{sub le} following inhibition of carrier insertion by brefeldin A (5 {mu}M) was similar

  14. Mixed Methods Research in School Psychology: A Mixed Methods Investigation of Trends in the Literature

    ERIC Educational Resources Information Center

    Powell, Heather; Mihalas, Stephanie; Onwuegbuzie, Anthony J.; Suldo, Shannon; Daley, Christine E.

    2008-01-01

    This article illustrates the utility of mixed methods research (i.e., combining quantitative and qualitative techniques) to the field of school psychology. First, the use of mixed methods approaches in school psychology practice is discussed. Second, the mixed methods research process is described in terms of school psychology research. Third, the…

  15. Patterns of Age Mixing and Gender Mixing among Children and Adolescents at an Ungraded School.

    ERIC Educational Resources Information Center

    Gray, Peter; Feldman, Jay

    1997-01-01

    Examined age and gender mixing among students, ages 4-19, at an ungraded, self-directed, democratically structured school. Found that age mixing was more frequent for 12- to 15-year-olds than for younger or older students, and that gender mixing was less frequent for 8- to 11-year-olds than for any other age group. (MDM)

  16. Physics of collisionless phase mixing

    SciTech Connect

    Tsiklauri, D.; Haruki, T.

    2008-11-15

    Previous studies of phase mixing of ion cyclotron (IC), Alfvenic, waves in the collisionless regime have established the generation of parallel electric field and hence acceleration of electrons in the regions of transverse density inhomogeneity. However, outstanding issues were left open. Here we use the 2.5 D, relativistic, fully electromagnetic particle-in-cell code and an analytic magnetohydrodynamic (MHD) formulation, to establish the following points: (i) Using the generalized Ohm's law we find that the parallel electric field is supported mostly by the electron pressure tensor, with a smaller contribution from the electron inertia term. (ii) The generated parallel electric field and the fraction of accelerated electrons are independent of the IC wave frequency remaining at a level of six orders of magnitude larger than the Dreicer value and approximately 20%, respectively. The generated parallel electric field and the fraction of accelerated electrons increase with the increase of IC wave amplitude. The generated parallel electric field seems to be independent of plasma beta, while the fraction of accelerated electrons strongly increases with the decrease of plasma beta (for plasma beta of 0.0001 the fraction of accelerated electrons can be as large as 47%). (iii) In the collisionless regime IC wave dissipation length (that is defined as the distance over which the wave damps) variation with the driving frequency shows a deviation from the analytical MHD result, which we attribute to a possible frequency dependence of the effective resistivity. (iv) Effective anomalous resistivity, inferred from our numerical simulations, is at least four orders of magnitude larger than the classical Spitzer value.

  17. The mixed waste management facility

    SciTech Connect

    Streit, R.D.

    1995-10-01

    During FY96, the Mixed Waste Management Facility (MWMF) Project has the following major objectives: (1) Complete Project Preliminary Design Review (PDR). (2) Complete final design (Title II) of MWMF major systems. (3) Coordinate all final interfaces with the Decontamination and Waste Treatment Facility (DWTF) for facility utilities and facility integration. (4) Begin long-lead procurements. (5) Issue Project Baseline Revision 2-Preliminary Design (PB2), modifying previous baselines per DOE-requested budget profiles and cost reduction. Delete Mediated Electrochemical Oxidation (MEO) as a treatment process for initial demonstration. (6) Complete submittal of, and ongoing support for, applications for air permit. (7) Begin detailed planning for start-up, activation, and operational interfaces with the Laboratory`s Hazardous Waste Management Division (HWM). In achieving these objectives during FY96, the Project will incorporate and implement recent DOE directives to maximize the cost savings associated with the DWTF/MWMF integration (initiated in PB1.2); to reduce FY96 new Budget Authority to {approximately}$10M (reduced from FY97 Validation of $15.3M); and to keep Project fiscal year funding requirements largely uniform at {approximately}$10M/yr. A revised Project Baseline (i.e., PB2), to be issued during the second quarter of FY96, will address the implementation and impact of this guidance from an overall Project viewpoint. For FY96, the impact of this guidance is that completion of final design has been delayed relative to previous baselines (resulting from the delay in the completion of preliminary design); ramp-up in staffing has been essentially eliminated; and procurements have been balanced through the Project to help balance budget needs to funding availability.

  18. Dilution Jet Mixing Program, phase 1

    NASA Technical Reports Server (NTRS)

    Srinivasan, R.; Berenfeld, A.; Mongia, H. C.

    1982-01-01

    The effect of jet to mainstream density ratio, flow area convergence as encounted in transition sections, and nonuniform mainstream profile upstream of dilution orifices on the mixing of a row of jets with a confined cross flow was quantified. It is found that: (1) jet spreading rate in transverse direction is increased with increasing J, H/D and with decreasing S/D; (2) the density ratio has only a second order effect on the jet mixing characteristics for a constant momentum ratio; (3) the temperature distributions in the jet mixing region are strongly influenced by the undisturbed mainstream profile; (4) flow area convergence enhances mixing in radial and transverse directions. An asymmetric convergent duct with flat wall injection has the same jet mixing characteristics as a symmetric convergent duct. An asymmetric convergent duct with slant wall injection has a faster jet spreading rate in the transverse direction.

  19. Continuous Microfluidic Mixing Using Pulsatile Micropumps

    NASA Astrophysics Data System (ADS)

    Deshmukh, Ajay; Liepmann, Dorian

    2000-11-01

    For many microfluidic and micro-TAS applications, the mixing of two fluids is required. At small length scales, however, traditional means of mixing, such as turbulence generation, are impossible yet diffusion is often too slow. For laminar mixing, 3 degrees of freedom are required. Since MEMS are normally 2-D, time-dependence is added for the third degree of freedom. This process involves the use of two positive displacement pumps to alternatively deliver two different fluids into a common channel and utilizing Taylor dispersion to mix them. This mixing process was modelled numerically and confirmed via experimental observation of fluorescent dye in a fabricated MEMS mixer. The pumps used in the device are a new design consisting of a bubble-piston and two check valves.

  20. Mixed waste characterization, treatment & disposal focus area

    SciTech Connect

    1996-08-01

    The mission of the Mixed Waste Characterization, Treatment, and Disposal Focus Area (referred to as the Mixed Waste Focus Area or MWFA) is to provide treatment systems capable of treating DOE`s mixed waste in partnership with users, and with continual participation of stakeholders, tribal governments, and regulators. The MWFA deals with the problem of eliminating mixed waste from current and future storage in the DOE complex. Mixed waste is waste that contains both hazardous chemical components, subject to the requirements of the Resource Conservation and Recovery Act (RCRA), and radioactive components, subject to the requirements of the Atomic Energy Act. The radioactive components include transuranic (TRU) and low-level waste (LLW). TRU waste primarily comes from the reprocessing of spent fuel and the use of plutonium in the fabrication of nuclear weapons. LLW includes radioactive waste other than uranium mill tailings, TRU, and high-level waste, including spent fuel.