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Sample records for 7 6 5

  1. 6 CFR 5.7 - Classified information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Freedom of Information Act § 5.7 Classified information. In processing a request for information that is classified under Executive Order 12958 (3 CFR, 1996 Comp., p. 333) or any other executive order, the... 6 Domestic Security 1 2011-01-01 2011-01-01 false Classified information. 5.7 Section 5.7...

  2. 6 CFR 5.7 - Classified information.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Freedom of Information Act § 5.7 Classified information. In processing a request for information that is classified under Executive Order 12958 (3 CFR, 1996 Comp., p. 333) or any other executive order, the... 6 Domestic Security 1 2014-01-01 2014-01-01 false Classified information. 5.7 Section 5.7...

  3. 6 CFR 5.7 - Classified information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Freedom of Information Act § 5.7 Classified information. In processing a request for information that is classified under Executive Order 12958 (3 CFR, 1996 Comp., p. 333) or any other executive order, the... 6 Domestic Security 1 2013-01-01 2013-01-01 false Classified information. 5.7 Section 5.7...

  4. 6 CFR 5.7 - Classified information.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Freedom of Information Act § 5.7 Classified information. In processing a request for information that is classified under Executive Order 12958 (3 CFR, 1996 Comp., p. 333) or any other executive order, the... 6 Domestic Security 1 2012-01-01 2012-01-01 false Classified information. 5.7 Section 5.7...

  5. 6 CFR 5.7 - Classified information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Freedom of Information Act § 5.7 Classified information. In processing a request for information that is classified under Executive Order 12958 (3 CFR, 1996 Comp., p. 333) or any other executive order, the... 6 Domestic Security 1 2010-01-01 2010-01-01 false Classified information. 5.7 Section 5.7...

  6. 7 CFR 6.5 - Hearings under section 22.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Hearings under section 22. 6.5 Section 6.5 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES General Provisions § 6.5 Hearings under... discharge the responsibility for action under section 22 vested in him by §§ 6.2 and 6.4(a). In view of...

  7. 7 CFR 6.5 - Hearings under section 22.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Hearings under section 22. 6.5 Section 6.5 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES General Provisions § 6.5 Hearings under... discharge the responsibility for action under section 22 vested in him by §§ 6.2 and 6.4(a). In view of...

  8. 7 CFR 1774.5-1774.6 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 12 2011-01-01 2011-01-01 false 1774.5-1774.6 Section 1774.5-1774.6 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) SPECIAL EVALUATION ASSISTANCE FOR RURAL COMMUNITIES AND HOUSEHOLDS PROGRAM (SEARCH)...

  9. 7 CFR 1774.5-1774.6 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 12 2014-01-01 2013-01-01 true 1774.5-1774.6 Section 1774.5-1774.6 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) SPECIAL EVALUATION ASSISTANCE FOR RURAL COMMUNITIES AND HOUSEHOLDS PROGRAM (SEARCH)...

  10. 40 CFR 721.9504 - Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8-tridecafluorooctyl)-.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Silane, triethoxy (3,3,4,4,5,5, 6,6,7... Significant New Uses for Specific Chemical Substances § 721.9504 Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8... substance identified as silane, triethoxy (3,3,4,4,5, 5,6,6,7,7,8,8,8-tridecafluorooctyl)- (PMN...

  11. 40 CFR 721.9504 - Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8-tridecafluorooctyl)-.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Silane, triethoxy (3,3,4,4,5,5, 6,6,7... Significant New Uses for Specific Chemical Substances § 721.9504 Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8... substance identified as silane, triethoxy (3,3,4,4,5, 5,6,6,7,7,8,8,8-tridecafluorooctyl)- (PMN...

  12. 40 CFR 721.9504 - Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8-tridecafluorooctyl)-.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Silane, triethoxy (3,3,4,4,5,5, 6,6,7... Significant New Uses for Specific Chemical Substances § 721.9504 Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8... substance identified as silane, triethoxy (3,3,4,4,5, 5,6,6,7,7,8,8,8-tridecafluorooctyl)- (PMN...

  13. 40 CFR 721.9504 - Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8-tridecafluorooctyl)-.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Silane, triethoxy (3,3,4,4,5,5, 6,6,7... Significant New Uses for Specific Chemical Substances § 721.9504 Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8... substance identified as silane, triethoxy (3,3,4,4,5, 5,6,6,7,7,8,8,8-tridecafluorooctyl)- (PMN...

  14. 40 CFR 721.9504 - Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8-tridecafluorooctyl)-.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Silane, triethoxy (3,3,4,4,5,5, 6,6,7... Significant New Uses for Specific Chemical Substances § 721.9504 Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8... substance identified as silane, triethoxy (3,3,4,4,5, 5,6,6,7,7,8,8,8-tridecafluorooctyl)- (PMN...

  15. Trisodium citrate, Na3(C6H5O7)

    PubMed Central

    Rammohan, Alagappa; Kaduk, James A.

    2016-01-01

    The crystal structure of anhydrous tris­odium citrate, Na3(C6H5O7), has been solved and refined using synchrotron X-ray powder diffraction data, and optimized using density functional theory (DFT). There are two independent five-coordinate Na+ and one six-coordinate Na+ cations in the asymmetric unit. The [NaO5] and [NaO6] polyhedra share edges and corners to form a three-dimensional framework. There are channels parallel to the a and b axes in which the remainder of the citrate anions reside. The only hydrogen bonds are an intra­molecular one between the hy­droxy group and one of the terminal carboxyl­ate O atoms and an intermolecular one between a methylene group and the hydroxyl O atom. PMID:27308044

  16. Rare-earth plasma extreme ultraviolet sources at 6.5-6.7 nm

    SciTech Connect

    Otsuka, Takamitsu; Higashiguchi, Takeshi; Yugami, Noboru; Yatagai, Toyohiko; Kilbane, Deirdre; White, John; Dunne, Padraig; O'Sullivan, Gerry; Jiang, Weihua; Endo, Akira

    2010-09-13

    We have demonstrated a laser-produced plasma extreme ultraviolet source operating in the 6.5-6.7 nm region based on rare-earth targets of Gd and Tb coupled with a Mo/B{sub 4}C multilayer mirror. Multiply charged ions produce strong resonance emission lines, which combine to yield an intense unresolved transition array. The spectra of these resonant lines around 6.7 nm (in-band: 6.7 nm {+-}1%) suggest that the in-band emission increases with increased plasma volume by suppressing the plasma hydrodynamic expansion loss at an electron temperature of about 50 eV, resulting in maximized emission.

  17. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  18. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  19. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  20. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  1. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  2. E. coli QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase†

    PubMed Central

    McCarty, Reid M.; Somogyi, Árpád; Bandarian, Vahe

    2009-01-01

    To elucidate the early steps required during biosynthesis of a broad class of 7-deazapurine containing natural products, we have studied the reaction catalyzed by Escherichia coli QueD, a 6-pyruvoyl-5,6,7,8-tetrahydropterin synthase (PTPS) homolog possibly involved in queuosine biosynthesis. While mammalian PTPS homologs convert 7,8-dihydroneopterin triphosphate (H2NTP) to 6-pyruvoyltetrahydropterin (PPH4) in biopterin biosynthesis, E. coli QueD catalyzes the conversion of H2NTP to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4). E. coli QueD can also convert PPH4 and sepiapterin to CPH4, allowing a mechanism to be proposed. PMID:19231875

  3. AN ATLAS OF z = 5.7 AND z = 6.5 Ly{alpha} EMITTERS ,

    SciTech Connect

    Hu, E. M.; Cowie, L. L.; Barger, A. J.; Capak, P.; Kakazu, Y.; Trouille, L. E-mail: cowie@ifa.hawaii.ed E-mail: trouille@astro.wisc.ed E-mail: kakazu@astro.caltech.ed

    2010-12-10

    We present an atlas of 88 z {approx} 5.7 and 30 z {approx} 6.5 Ly{alpha} emitters obtained from a wide-field narrowband survey. We combined deep narrowband imaging in 120 A bandpass filters centered at 8150 A and 9140 A with deep BVRIz broadband imaging to select high-redshift galaxy candidates over an area of 4180 arcmin{sup 2}. The goal was to obtain a uniform selection of comparable depth over the seven targeted fields in the two filters. For the GOODS-North region of the Hubble Deep Field-North field, we also selected candidates using a 120 A filter centered at 9210 A. We made spectroscopic observations with Keck DEIMOS of nearly all the candidates to obtain the final sample of Ly{alpha} emitters. At the 3.3 A resolution of the DEIMOS observations the asymmetric profile for Ly{alpha} emission can be clearly seen in the spectra of nearly all the galaxies. We show that the spectral profiles are surprisingly similar for many of the galaxies and that the composite spectral profiles are nearly identical at z = 5.7 and z = 6.5. We analyze the distributions of line widths and Ly{alpha} equivalent widths and find that the lines are marginally narrower at the higher redshift, with median values of 0.77 A at z = 6.5 and 0.92 A at z = 5.7. The line widths have a dependence on the Ly{alpha} luminosity of the form {approx}L {sup 0.3}{sub {alpha}}. We compare the surface densities and the luminosity functions at the two redshifts and find that there is a multiplicative factor of two decrease in the number density of bright Ly{alpha} emitters from z = 5.7 to z = 6.5, while the characteristic luminosity is unchanged.

  4. The fourth spectrum of platinum (Pt IV): Determination of the 5d7, 5d6 6 s and 5d6 6 p configurations

    NASA Astrophysics Data System (ADS)

    Azarov, Vladimir I.; Gayasov, Robert R.

    2016-03-01

    The spectrum of three times ionized platinum, Pt IV, was investigated in the 530-1800 Å wavelength region. The analysis has resulted in the determination of the 5d7, 5d66s and 5d66p configurations. Seventeen of 19 theoretically possible 5d7 levels, 58 of 63 possible 5d66s levels and 162 of 180 possible 5d66p levels have been established. The levels are based on 1478 classified spectral lines. The level structure and transition probabilities were calculated by means of the orthogonal operators method. The energy parameters have been determined by the least squares fit to the observed levels. Calculated energy values and LS-compositions, as well as gA values obtained from the fitted parameter values are presented.

  5. An Atlas of z = 5.7 and z = 6.5 Lyα Emitters

    NASA Astrophysics Data System (ADS)

    Hu, E. M.; Cowie, L. L.; Barger, A. J.; Capak, P.; Kakazu, Y.; Trouille, L.

    2010-12-01

    We present an atlas of 88 z ~ 5.7 and 30 z ~ 6.5 Lyα emitters obtained from a wide-field narrowband survey. We combined deep narrowband imaging in 120 Å bandpass filters centered at 8150 Å and 9140 Å with deep BVRIz broadband imaging to select high-redshift galaxy candidates over an area of 4180 arcmin2. The goal was to obtain a uniform selection of comparable depth over the seven targeted fields in the two filters. For the GOODS-North region of the Hubble Deep Field-North field, we also selected candidates using a 120 Å filter centered at 9210 Å. We made spectroscopic observations with Keck DEIMOS of nearly all the candidates to obtain the final sample of Lyα emitters. At the 3.3 Å resolution of the DEIMOS observations the asymmetric profile for Lyα emission can be clearly seen in the spectra of nearly all the galaxies. We show that the spectral profiles are surprisingly similar for many of the galaxies and that the composite spectral profiles are nearly identical at z = 5.7 and z = 6.5. We analyze the distributions of line widths and Lyα equivalent widths and find that the lines are marginally narrower at the higher redshift, with median values of 0.77 Å at z = 6.5 and 0.92 Å at z = 5.7. The line widths have a dependence on the Lyα luminosity of the form ~L 0.3 α. We compare the surface densities and the luminosity functions at the two redshifts and find that there is a multiplicative factor of two decrease in the number density of bright Lyα emitters from z = 5.7 to z = 6.5, while the characteristic luminosity is unchanged. Based in part on data collected at the Subaru Telescope, which is operated by the National Astronomical Observatory of Japan. Based in part on data obtained at the W. M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California, and NASA and was made possible by the generous financial support of the W. M. Keck Foundation.

  6. 5,7-Dihydroxy-6,4'-dimeth-oxyflavone.

    PubMed

    Mou, Ming-Yue; Pi, Ke; Zhang, Qi-Long; Zhang, Yun-Qian; Zhang, Qian-Jun

    2007-01-01

    In the title compound, C(17)H(14)O(6), the benzopyran ring system is essentially planar and forms a dihedral angle of 6.84 (4)° with the other benzene ring. In the crystal structure, centrosymmetrically related mol-ecules are linked into dimers by O-H⋯O hydrogen bonds. The crystal packing is controlled by C-H⋯π and π-π stacking inter-actions involving the benzopyran and benzene rings, with centroid-centroid distances between 3.645 (2) and 3.986 (2) Å. PMID:21200948

  7. 7 CFR 5.6 - Revision of the parity price of a commodity.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Revision of the parity price of a commodity. 5.6 Section 5.6 Agriculture Office of the Secretary of Agriculture DETERMINATION OF PARITY PRICES § 5.6 Revision of the parity price of a commodity. (a) Initiation of hearings. The “modernized” parity...

  8. 7 CFR 5.6 - Revision of the parity price of a commodity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Revision of the parity price of a commodity. 5.6 Section 5.6 Agriculture Office of the Secretary of Agriculture DETERMINATION OF PARITY PRICES § 5.6 Revision of the parity price of a commodity. (a) Initiation of hearings. The “modernized” parity...

  9. 7 CFR 5.6 - Revision of the parity price of a commodity.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 1 2014-01-01 2014-01-01 false Revision of the parity price of a commodity. 5.6 Section 5.6 Agriculture Office of the Secretary of Agriculture DETERMINATION OF PARITY PRICES § 5.6 Revision of the parity price of a commodity. (a) Initiation of hearings. The “modernized” parity...

  10. 7 CFR 5.6 - Revision of the parity price of a commodity.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Revision of the parity price of a commodity. 5.6 Section 5.6 Agriculture Office of the Secretary of Agriculture DETERMINATION OF PARITY PRICES § 5.6 Revision of the parity price of a commodity. (a) Initiation of hearings. The “modernized” parity...

  11. 7 CFR 5.6 - Revision of the parity price of a commodity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false Revision of the parity price of a commodity. 5.6 Section 5.6 Agriculture Office of the Secretary of Agriculture DETERMINATION OF PARITY PRICES § 5.6 Revision of the parity price of a commodity. (a) Initiation of hearings. The “modernized” parity...

  12. 8 CFR 1236.4 - Removal of S-5, S-6, and S-7 nonimmigrants.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Removal of S-5, S-6, and S-7 nonimmigrants... OF ALIENS ORDERED REMOVED Detention of Aliens Prior to Order of Removal § 1236.4 Removal of S-5, S-6, and S-7 nonimmigrants. (a) Condition of classification. As a condition of classification and...

  13. 8 CFR 1236.4 - Removal of S-5, S-6, and S-7 nonimmigrants.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Removal of S-5, S-6, and S-7 nonimmigrants... OF ALIENS ORDERED REMOVED Detention of Aliens Prior to Order of Removal § 1236.4 Removal of S-5, S-6, and S-7 nonimmigrants. (a) Condition of classification. As a condition of classification and...

  14. Synthesis and biological activity of substituted-4,5,6,7-tetrahydrothieno pyridines: a review.

    PubMed

    Sangshetti, Jaiprakash N; Zambare, Abhay S; Khan, Firoz A Kalam; Gonjari, Indrajeet; Zaheer, Zahid

    2014-01-01

    4,5,6,7-Tetrahydrothieno pyridine is an important class of heterocyclic nucleus. Various 4,5,6,7-tetrahydrothieno pyridine derivatives have been synthesized and evaluated for various biological activities in different models with desired findings. Some analogs have shown potent biological activities and may be considered as lead molecule for the development of future drugs. Number of drug molecules are available in the market and many molecules are in clinical development containing 4,5,6,7-tetrahydrothieno pyridine nucleus as an important core. This review is an attempt to organize the chemical and biological aspects of 4,5,6,7-tetrahydrothieno pyridine analogs reported in last 20 year to till date. Review mainly focuses on the important role of the core in synthesis of drug or drug intermediates giving emphasis on synthetic schemes and biological activities of the different 4,5,6,7-tetrahydrothieno pyridine analogs. PMID:25373848

  15. 5. CONTEXTUAL VIEW WEST OF (LEFT TO RIGHT) FEATURES 7,6,2,8, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. CONTEXTUAL VIEW WEST OF (LEFT TO RIGHT) FEATURES 7,6,2,8, AND 1 WITHIN MILL COMPLEX. - Juniata Mill Complex, 22.5 miles Southwest of Hawthorne, between Aurora Crater & Aurora Peak, Hawthorne, Mineral County, NV

  16. Crystal structure of 2-amino-7,7-dimethyl-5-oxo-4-(pyridin-4-yl)-5,6,7,8-tetrahydro-4 H-chromene-3-carbonitrile hemihydrate

    NASA Astrophysics Data System (ADS)

    Sharma, N.; Banerjee, B.; Brahmachari, G.; Kant, R.; Gupta, V. K.

    2015-12-01

    The title compound, 2-amino-7,7-dimethyl-5-oxo-4-(pyridin-4-yl)-5,6,7,8-tetrahydro-4 Hchromene-3-carbonitrile was synthesized by multicomponent reaction at room temperature using commercially available urea as inexpensive and environmentally benign organo-catalyst. Its structure was determined by X-ray structure analysis. The crystals are monoclinic, sp. gr. C2/ c, a = 22.010(6), b = 11.0364(10), c = 17.147(4) Å, β = 130.37(4)°, Z = 8, R = 0.0433 for 2377 observed reflections.

  17. Km and kcat. values for [6,6,7,7-2H]7,8(6H)-dihydropterin and 2,6-diamino-5-iminopyrimidin-4-one with dihydropteridine reductase.

    PubMed Central

    Armarego, W L; Randles, D; Taguchi, H

    1983-01-01

    The Km and kcat. values for [6,6,7,7-2H]7,8(6H)-dihydropterin and 2,6-diamino-5-iminopyrimidin-4-one were determined for dihydropteridine reductase (EC 1.6.99.10) from two sources. The parameters of the pterin are of the same order as those of the most effective substrates of dihydropteridine reductase. The Km values of the pterin are one order of magnitude smaller than those of the pyrimidinone, although the kcat. values are of the same order. PMID:6870836

  18. 8 CFR 236.4 - Removal of S-5, S-6, and S-7 nonimmigrants.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Removal of S-5, S-6, and S-7 nonimmigrants... of Aliens Prior to Order of Removal § 236.4 Removal of S-5, S-6, and S-7 nonimmigrants. (a) Condition... section 101(a)(15)(S) of the Act, nonimmigrants in S classification must have executed Form I-854, Part...

  19. 8 CFR 236.4 - Removal of S-5, S-6, and S-7 nonimmigrants.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Removal of S-5, S-6, and S-7 nonimmigrants... of Aliens Prior to Order of Removal § 236.4 Removal of S-5, S-6, and S-7 nonimmigrants. (a) Condition... section 101(a)(15)(S) of the Act, nonimmigrants in S classification must have executed Form I-854, Part...

  20. IMMUNOHISTOCHEMICAL ANALYSIS OF ZNT1, 4, 5, 6, AND 7 IN THE MOUSE GASTROINTESTINAL TRACT

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Expression of five zinc transporters (ZnT1, 4, 5, 6, and 7) of the Slc30 family in the mouse gastrointestinal tract was studied by immunohistochemical analysis. The results demonstrated unique expression patterns, levels, and cellular localization among ZnT proteins in the mouse gastrointestinal tra...

  1. Enantioselective route to 5-methyl- and 5,7-dimethyl-6,7-dihydro-5H-dibenz[c,e]azepine: secondary amines with switchable axial chirality.

    PubMed

    Pira, Silvain L; Wallace, Timothy W; Graham, Jonathan P

    2009-04-01

    (-)-5-Methyl-6,7-dihydro-5H-dibenz[c,e]azepine 4, a new secondary amine featuring an axis-center stereochemical relay, was prepared enantioselectively from 2'-acetylbiphenyl-2-carboxylic acid, using (R)-2-phenylglycinol as an auxiliary for the control of both elements of chirality. The biaryl axis in 4 preferentially adopts the aS-configuration, with the methyl substituent pseudoequatorial, but conversion into the corresponding N-Boc derivative locks the axis into the aR-configuration, as predicted on the basis of molecular mechanics calculations. PMID:19275220

  2. High antiallergic activity of 5,6,4'-trihydroxy-7,8,3'-trimethoxyflavone and 5,6-dihydroxy-7,8,3',4'-tetramethoxyflavone from eau de cologne mint (Mentha×piperita citrata).

    PubMed

    Sato, Akihiko; Tamura, Hirotoshi

    2015-04-01

    The following compounds with higher antiallergic activities were isolated from eau de cologne mint leaves: 5,6,4'-trihydroxy-7,8-dimethoxyflavone (6), 5,6,4'-trihydroxy-7,8,3'-trimethoxyflavone (7), 5,6-dihydroxy-7,3',4'-trimethoxyflavone (8), 5,6-dihydroxy-7,8,3',4'-tetramethoxyflavone (9), and 5,6-dihydroxy-7,8,4'-trimethoxyflavone (10). The IC50 values of compounds 6-10 against RBL-2H3 cells were 6.7, 2.4, 5.6, 3.0, and 6.1μM. Compounds 7 and 9 (IC50 2.4μM and 3.0μM) had the highest antiallergic activities among the flavonoids previously reported. The amounts of 7, 9, and 10 isolated were fairly high, at 177.7mg/kg, 278.0mg/kg, and 179.7mg/kg in the mint, respectively. LD5 value (index of toxicity) and LD5/IC50 ratio of 7 and 9 indicate that the safety is greater than that of luteolin, a typical antiallergic substance. The extract containing powerful antiallergic flavones, 6-10 with higher hydrophobicity could be selectively separated from the extract containing luteolin and other flavonoid glycosides by partition with dichloromethane and water. Therefore, compounds 7 and 9 in mint, and the dichloromethane extract would be the most potent and preventive resources against type I allergy. PMID:25704366

  3. Synthesis and Crystal Structures of Hg 6Sb 5Br 7, Hg 6As 4BiCl 7, and Hg 6Sb 4BiBr 7, Built of a Polycationic Mercury-Pnictide Framework with Trapped Anions

    NASA Astrophysics Data System (ADS)

    Beck, Johannes; Hedderich, Sylvia; Neisel, Udo

    2000-11-01

    Hg6Sb5Br7, Hg6As4BiCl7, and Hg6Sb4BiBr7 were prepared from stoichiometric mixtures of Hg2X2, HgX2 (X=Cl, Br), As, Sb, and Bi in sealed, evacuated glass ampoules in temperature gradients 260→240°C for Hg6Sb5Br7, 340→320°C for Hg6As4BiCl7, and 290→270°C for Hg6Sb4BiBr7. All compounds crystallize in the cubic space group Paoverline3 with Z=4 and the lattice constants a=13.003(1) Å for Hg6Sb5Br7, a=12.178(2) Å for Hg6As4BiCl7, and a=12.998(4) Å for Hg6Sb4BiBr7. The structures have been solved based on single-crystal X-ray diffraction data and refined to R(F)=0.0431, 666 Fo for Hg6Sb5Br7, R(F)=0.0478, 690 Fo for Hg6As4BiCl7, and R(F)=0.0444, 840 Fo for Hg6Sb4BiBr7 with 30 parameters for each refinement. The structures are characterized by a three-dimensional polycationic framework of pnictide dumb-bells (As-As distance 2.43 Å, Sb-Sb distance 2.78 Å), each connected by six mercury atoms to six neighbored As2/Sb2 groups. There are two different cages in the framework; one type is occupied by nearly regular MX6 octahedra (M=Sb,Bi; X=Cl, Br), the other by halide ions. The three compounds crystallize closely related to Cd7P4Cl6, which contains a similar polycationic framework of P2 dumb-bells connected by Cd, but with only one type of cage occupied by octahedral [CdCl6]4- ions. The interactions between the atoms of the polycationic framework and the anions are very weak. The observed diamagnetism of all three compounds is in agreement with the ionic formulas (Hg6Sb4)4+[SbBr6]3-Br-, (Hg6As4)4+[BiCl6]3-Cl-, and (Hg6Sb4)4+[BiBr6]3-Br-.

  4. 5I 75I 8 infrared luminescence spectrum of Cs 2NaHoCl 6

    NASA Astrophysics Data System (ADS)

    Tanner, Peter A.

    1985-08-01

    The 300-15 K luminescence spectrum of Cs 2NaHoCl 6 is reported for the spectral region 4550-5300 cm -1. In agreement with the calculated magnetic dipole (MD) intensity ratios, twenty MD allowed pure electronic transitions are observed and assigned, corresponding to transitions between the crystal field components of 5I 75I 8. The ungerade vibronic origins associated with these transitions are at least an order of magnitude weaker. All of the crystal field levels of the 5I 7, 5I 8 Russell—Saunders terms are assigned from the spectral analysis. The long-term lifetime of the 5I 7 levels is near 50 ms at 85 K.

  5. 1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists.

    PubMed

    Fabritius, Charles-Henry; Pesonen, Ullamari; Messinger, Josef; Horvath, Raymond; Salo, Harri; Gałęzowski, Michał; Galek, Mariusz; Stefańska, Klaudia; Szeremeta-Spisak, Joanna; Olszak-Płachta, Marta; Buda, Anna; Adamczyk, Justyna; Król, Marcin; Prusis, Peteris; Sieprawska-Lupa, Magdalena; Mikulski, Maciej; Kuokkanen, Katja; Chapman, Hugh; Obuchowicz, Radosław; Korjamo, Timo; Jalava, Niina; Nowak, Mateusz

    2016-06-01

    A series of 1-Sulfonyl-6-Piperazinyl-7-Azaindoles, showing strong antagonistic activity to 5-HT6 receptor (5-HT6R) was synthesized and characterized. The series was optimized to reduce activity on D2 receptor. Based on the selectivity against this off-target and the analysis of the ADME-tox profile, compound 1c was selected for in vivo efficacy assessment, which demonstrated procognitive effects as shown in reversal of scopolamine induced amnesia in an elevated plus maze test in mice. Compound 3, the demethylated version of compound 1c, was profiled against a panel of 106 receptors, channels and transporters, indicating only D3 receptor as a major off-target. Compound 3 has been selected for this study over compound 1c because of the higher 5-HT6R/D2R binding ratio. These results have defined a new direction for the design of our pseudo-selective 5-HT6R antagonists. PMID:27117428

  6. Sodium dipotassium citrate, NaK2C6H5O7.

    PubMed

    Rammohan, Alagappa; Kaduk, James A

    2016-03-01

    The crystal structure of sodium dipotassium citrate, Na(+)·2K(+)·C6H5O7 (3-), has been solved and refined using laboratory X-ray powder diffraction data, and optimized using density functional techniques. The Na(+) and one of the K(+) cations are six-coordinate, with bond-valence sums of 1.13 and 0.92 valence units, respectively, while another crystallographically independent K(+) cation is seven-coordinate with a bond-valence sum of 1.20. The [KO6] and [KO7] polyhedra share edges and corners to form layers perpendicular to the b axis. The distorted [NaO6] octa-hedra share edges to form chains along the a axis. The result is a three-dimensional network. The only O-H⋯O hydrogen bond is an intra-molecular one between the hy-droxy group and a terminal carboxyl-ate group. PMID:27006817

  7. Calibration of NOAA-7 AVHRR, GOES-5 and GOES-6 VISSR/VAS solar channels

    NASA Technical Reports Server (NTRS)

    Frouin, R.; Gautier, C.

    1986-01-01

    The NOAA-7, GOES-5 and GOES-6 Visible Infrared Spin Scan Radiometer/Vertical Atmospheric Sounder (VISSR/VAS) solar channels were calibrated. The White Sands Monument area in New Mexico, whose reflectance properties are well known, and space are used as calibration targets. The shortwave reflected terrestrial irradiance that is measured at satellite altitude is computed using a fairly accurate radiative transfer model which accounts for multiple scattering and bidirectional effects. The ground target reflectance and relevant characteristics of the overlying atmosphere are estimated from climatological data and observation at the nearest meteorological sites. The approach is believed to produce accuracies of 8 to 13% depending on the channel considered.

  8. Ligubenzocycloheptanone A, a Novel Tricyclic Butenolide with a 6/7/5 Skeleton from Ligusticum chuanxiong

    PubMed Central

    Han, Bing; Zhang, Xu; Feng, Zi-Ming; Jiang, Jian-Shuang; Li, Li; Yang, Ya-Nan; Zhang, Pei-Cheng

    2016-01-01

    Ligubenzocycloheptanone A (1), a novel tricyclic butenolide with a 6/7/5-membered ring skeleton, was isolated from the rhizome of Ligusticum chuanxiong. Its unusual structure was determined using UV, IR, HRESIMS, 1D and 2D NMR data, X-ray diffraction crystallography and by the comparison of experimental and calculated electronic circular dichroism (ECD) spectra. 1 possessed a benzocycloheptanone core featuring butyrolactone, which is rarely observed in nature. A possible biosynthetic pathway was proposed. Ligubenzocycloheptanone A showed strong radical scavenging activity with an IC50 value of 2.3 μM. PMID:27461841

  9. Ligubenzocycloheptanone A, a Novel Tricyclic Butenolide with a 6/7/5 Skeleton from Ligusticum chuanxiong

    NASA Astrophysics Data System (ADS)

    Han, Bing; Zhang, Xu; Feng, Zi-Ming; Jiang, Jian-Shuang; Li, Li; Yang, Ya-Nan; Zhang, Pei-Cheng

    2016-07-01

    Ligubenzocycloheptanone A (1), a novel tricyclic butenolide with a 6/7/5-membered ring skeleton, was isolated from the rhizome of Ligusticum chuanxiong. Its unusual structure was determined using UV, IR, HRESIMS, 1D and 2D NMR data, X-ray diffraction crystallography and by the comparison of experimental and calculated electronic circular dichroism (ECD) spectra. 1 possessed a benzocycloheptanone core featuring butyrolactone, which is rarely observed in nature. A possible biosynthetic pathway was proposed. Ligubenzocycloheptanone A showed strong radical scavenging activity with an IC50 value of 2.3 μM.

  10. Synthesis of 5,6-dihydro-4H-benzo[d]isoxazol-7-one and 5,6-dihydro-4H-isoxazolo[5,4-c]pyridin-7-one derivatives as potential Hsp90 inhibitors.

    PubMed

    Musso, Loana; Cincinelli, Raffaella; Giannini, Giuseppe; Manetti, Fabrizio; Dallavalle, Sabrina

    2015-11-01

    A novel class of 5,6-dihydro-4H-benzo[d]isoxazol-7-ones and 5,6-dihydro-4H-isoxazolo[5,4-c]pyridin-7-ones was designed, synthesized, and assayed to investigate the affinity toward Hsp90 protein. The synthetic route was based on a 1,3-dipolar cycloaddition of nitriloxides, generated in situ from suitable benzaldoximes, with 2-bromocyclohex-2-enones or 3-bromo-5,6-dihydro-1H-pyridin-2-ones. Whereas all the compounds bearing a benzamide group on the bicyclic scaffold were devoid of activity, the derivatives carrying a resorcinol-like fragment showed a remarkable inhibitory effect on Hsp90. Docking calculations were performed to investigate the orientation of the new compounds within the binding site of the enzyme. PMID:25855505

  11. Sodium dipotassium citrate, NaK2C6H5O7

    PubMed Central

    Rammohan, Alagappa; Kaduk, James A.

    2016-01-01

    The crystal structure of sodium dipotassium citrate, Na+·2K+·C6H5O7 3−, has been solved and refined using laboratory X-ray powder diffraction data, and optimized using density functional techniques. The Na+ and one of the K+ cations are six-coordinate, with bond-valence sums of 1.13 and 0.92 valence units, respectively, while another crystallographically independent K+ cation is seven-coordinate with a bond-valence sum of 1.20. The [KO6] and [KO7] polyhedra share edges and corners to form layers perpendicular to the b axis. The distorted [NaO6] octa­hedra share edges to form chains along the a axis. The result is a three-dimensional network. The only O—H⋯O hydrogen bond is an intra­molecular one between the hy­droxy group and a terminal carboxyl­ate group. PMID:27006817

  12. Novel approach to the zaragozic acids. Enantioselective total synthesis of 6,7-dideoxysqualestatin H5.

    PubMed

    Naito, Satoru; Escobar, Maya; Kym, Philip R; Liras, Spiros; Martin, Stephen F

    2002-06-14

    The total synthesis of 6,7-dideoxysqualestatin H5 (3) has been completed by a concise approach that features the stereoselective intramolecular vinylogous aldol reaction of the furoic ester 25a to give 30 or its trimethylsilyl ether derivative 34, which possess the requisite absolute stereochemistry at C(3)-C(5) of 3. Compound 34 was reduced to the saturated bislactone 39, and the C(1) side chain subunit 47 was introduced leading to a mixture of the hemiacetals 48 and the corresponding ketone 49. When this mixture was stirred with methanolic acid, transketalization occurred to give a mixture of 50 and the spirocyclic methyl acetals 51a,b. Oxidation of the primary alcohol group in 50 followed by saponification of the two remaining ester groups gave 3. The longest linear sequence in the synthesis commences with commercially available erythronolactone (26) and requires 17 chemical steps with only 10 isolated intermediates. PMID:12054955

  13. 2-Amino-4-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile.

    PubMed

    Khan, Ashraf Y; Fathima, Nikhath; Kalashetti, Mallikarjun B; Begum, Noor Shahina; Khazi, I M

    2012-10-01

    In the title compound, C(10)H(12)N(2)S, the thio-phene ring is essentially planar (r.m.s. deviation = 0.0290 Å). The two C atoms of the cyclo-hexene ring (at positions 6 and 7) are disordered over two sets of sites in a 0.810 (5):0.190 (5) ratio. The cyclo-hexene rings in both the major and minor occupancy conformers adopt a half-chair conformation. In the crystal, there are two types of N-H⋯N inter-action. One of these results in centrosymmetric head-to-head dimers corresponding to an R(2) (2)(12) graph-set motif and the other forms a 20-membered macrocyclic ring involving six mol-ecules. PMID:23125792

  14. Disodium hydrogen citrate sesquihydrate, Na2HC6H5O7(H2O)1.5

    PubMed Central

    Rammohan, Alagappa; Sarjeant, Amy A.; Kaduk, James A.

    2016-01-01

    The crystal structure of disodium hydrogen citrate sesquihydrate, 2Na2 +·C6H6O7 2−·1.5H2O, has been solved and refined using laboratory X-ray single-crystal diffraction data, and optimized using density functional techniques. The asymmetric unit contains two independent hydrogen citrate anions, four sodium cations and three water molecules. The coordination polyhedra of the cations (three with a coordination number of six, one with seven) share edges to form isolated 8-rings. The un-ionized terminal carb­oxy­lic acid groups form very strong hydrogen bonds to non-coordinating O atoms, with O⋯O distances of 2.46 Å. PMID:27555936

  15. Disodium hydrogen citrate sesquihydrate, Na2HC6H5O7(H2O)1.5.

    PubMed

    Rammohan, Alagappa; Sarjeant, Amy A; Kaduk, James A

    2016-07-01

    The crystal structure of disodium hydrogen citrate sesquihydrate, 2Na2 (+)·C6H6O7 (2-)·1.5H2O, has been solved and refined using laboratory X-ray single-crystal diffraction data, and optimized using density functional techniques. The asymmetric unit contains two independent hydrogen citrate anions, four sodium cations and three water molecules. The coordination polyhedra of the cations (three with a coordination number of six, one with seven) share edges to form isolated 8-rings. The un-ionized terminal carb-oxy-lic acid groups form very strong hydrogen bonds to non-coordinating O atoms, with O⋯O distances of 2.46 Å. PMID:27555936

  16. Analysis Of Spitzer IRS 5.6 To 7.7 μm Observations Of Comets 6P/d'Arrest And C/2007 N3 (Lulin)

    NASA Astrophysics Data System (ADS)

    Harker, David Emerson; Woodward, C. E.; Kelley, M. S.; Bockelee-Morvan, D.; Crovisier, J.; Wooden, D. H.

    2011-01-01

    The production rate of volatiles from comet nuclei through sublimation of ices is a measure of the activity and volatile abundance. Sublimation of water, the dominant ice in cometary bodies, is the main source of activity at heliocentric distances rh < 3 AU from the Sun. The water production rate (Q(H2O)), the rotational temperature (Trot) and the ortho-to-para ratio (OPR) are of particular interest in the study of cometary atmospheres and cometary physics, and cometary origins. We present Spitzer IRS 5.6 to 7.7 μm spectra of comets 6P/d'Arrest (6P) obtained 2008 Sept 12 UT (post-perihelion; rh = 1.39 AU), and C/2007 N3 (Lulin) obtained 2008 Oct 04 UT, (pre-perihelion; rh = 1.90 AU). The 6.3 μm ν2 vibrational band is detected in both comets. Both comets also show an as yet unidentified broad feature at 7.2 μm that appears in other IRS observations of comets. Fluorescence models of water emission are used to calculate Q(H2O), Trot, and OPR towards the nucleus of both comets and into the coma 9" and 18" away from the nucleus to assess the coma spatial distribution of Trot, and the OPR. Limits are placed on emission from controversial cometary constituents, carbonates and PAHs. Support for this work is provided in part by NASA through contract 1355318.

  17. Synthesis and characterization of a new cyclohexaphosphate, (C6H7ClN)6P6O18·0.5(H2O)

    NASA Astrophysics Data System (ADS)

    Khedhiri, L.; Jeanneau, E.; Lefebvre, F.; Rzaigui, M.; Ben Nasr, C.

    2016-02-01

    A new cyclohexaphosphate with the composition (C6H7ClN)6P6O18·0.5(H2O) has been synthesized at room temperature in the presence of 4-chloroaniline as organic template and investigated by various physicochemical techniques. Its unit cell is triclinic P-1 with parameters a = 9.0054(8), b = 10.1053(9), c = 16.4454(14) Å, α = 100.476(7), β = 93.485(7), γ = 115.407(9) °, Z = 2 and V = 1313.0(2)Å3. The structure involves a network of inorganic parallel layers built up by P6O186 - ring anions, NH3 groups and water molecules. Charge balance is achieved by the protonated amine which is trapped in the interlayer space and interacts with the organic framework through strong hydrogen bonding. The 13C, 15N and 31P CP-MAS NMR spectra are in agreement with the X-ray structure. The vibrational absorption bands were identified by infrared spectroscopy. DFT calculations allowed the attribution of the NMR peaks.

  18. 5,7-Dihydroxy-6-geranylflavanone improves insulin sensitivity through PPARα/γ dual activation.

    PubMed

    Lee, Woojung; Yoon, Goo; Kim, Min Cheol; Kwon, Hak Cheol; Bae, Gyu-Un; Kim, Yong Kee; Kim, Su-Nam

    2016-05-01

    In the present study, we demonstrate that 5,7-dihydroxy-6-geranylflavanone (DGF) isolated from Amorpha fruticosa (A. fruticosa) is a novel peroxisome proliferator-activated receptor (PPAR)α/γ dual agonist which may be used to improve insulin sensitivity. The extract from A. fruticosa increased the transcriptional activity of both PPARα and PPARγ which was, in part, driven by the active ingredient DGF. Treatment with DGF markedly enhanced the adipogenesis of 3T3-L1 preadipocytes, which was comparable to the effect of the PPARγ agonist, troglitazone. In addition, DGF was found to enhance fatty acid oxidation and glucose utilization through the dual activation of PPARα/γ. In addition treatment with DGF led to an improvement in insulin sensitivity, resulting in enhanced glucose uptake in muscle cells. The findings of our study data suggest that DGF may be used as potential therapeutic agent in the treatment of type 2 diabetes and related metabolic disorders by enhancing glucose and lipid metabolism. PMID:26986637

  19. Process for manufacturing bis(2-methoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracene

    SciTech Connect

    Rasmussen, Paul George; Lawton, Richard Graham

    2014-06-03

    A process to manufacture substituted tetracyano-hexaazatricyclics with the substitutions occurring at the 9 and 10 hydrogens. The process begins with 2,3-dichloro-5,6-dicyanopyrazine, which is reacted to form the desired tetracyano-hexaazatricyclic. Different process embodiments enable different reaction paths to the desired tetracyano-hexaazatricyclic. Different tetracyano-hexaazatricyclic embodiments include bis(2-methoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracene and bis(2-methoxyethoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracen- e.

  20. Advanced Gas Reactor (AGR)-5/6/7 Fuel Irradiation Experiments in the Advanced Test Reactor

    SciTech Connect

    A. Joseph Palmer; David A. Petti; S. Blaine Grover

    2014-04-01

    The United States Department of Energy’s Very High Temperature Reactor (VHTR) Advanced Gas Reactor (AGR) Fuel Development and Qualification Program will be irradiating up to seven separate low enriched uranium (LEU) tri-isotopic (TRISO) particle fuel (in compact form) experiments in the Advanced Test Reactor (ATR) located at the Idaho National Laboratory (INL). These irradiations and fuel development are being accomplished to support development of the next generation reactors in the United States. The goals of the irradiation experiments are to provide irradiation performance data to support fuel process development, to qualify fuel for normal operating conditions, to support development and validation of fuel performance and fission product transport models and codes, and to provide irradiated fuel and materials for post irradiation examination (PIE) and safety testing. The experiments, which each consist of at least five separate capsules, are being irradiated in an inert sweep gas atmosphere with individual on-line temperature monitoring and control of each capsule. The sweep gases also have on-line fission product monitoring the effluent from each capsule to track performance of the fuel during irradiation. The first two experiments (designated AGR-1 and AGR-2), have been completed. The third and fourth experiments have been combined into a single experiment designated AGR-3/4, which started its irradiation in December 2011 and is currently scheduled to be completed in April 2014. The design of the fuel qualification experiment, designated AGR-5/6/7, is well underway and incorporates lessons learned from the three previous experiments. Various design issues will be discussed with particular details related to selection of thermometry.

  1. Accelerations from the September 5, 2012 (Mw=7.6) Nicoya, Costa Rica Earthquake

    NASA Astrophysics Data System (ADS)

    Simila, G. W.; Quintero, R.; Burgoa, B.; Mohammadebrahim, E.; Segura, J.

    2013-05-01

    Since 1984, the Seismic Network of the Volcanological and Seismological Observatory of Costa Rica, Universidad Nacional (OVSICORI-UNA) has been recording and registering the seismicity in Costa Rica. Before September 2012, the earthquakes registered by this seismic network in northwestern Costa Rica were moderate to small, except the Cóbano earthquake of March 25, 1990, 13:23, Mw 7.3, lat. 9.648, long. 84.913, depth 20 km; a subduction quake at the entrance of the Gulf of Nicoya and generated peak intensities in the range of MM = VIII near the epicentral area and VI-VII in the Central Valley of Costa Rica. Six years before the installation of the seismic network, OVSICORI-UNA registered two subduction earthquakes in northwestern Costa Rica, specifically on August 23, 1978, at 00:38:32 and 00:50:29 with magnitudes Mw 7.0 (HRVD), Ms 7.0 (ISC) and depths of 58 and 69 km, respectively (EHB Bulletin). On September 5, 2012, at 14:42:02.8 UTC, the seismic network OVSICORI-UNA registered another large subduction earthquake in Nicoya peninsula, northwestern Costa Rica, located 29 km south of Samara, with a depth of 21 km and magnitude Mw 7.6, lat. 9.6392, long. 85.6167. This earthquake was caused by the subduction of the Cocos plate under the Caribbean plate in northwestern Costa Rica. This earthquake was felt throughout the country and also in much of Nicaragua. The instrumental intensity map for the Nicoya earthquake indicates that the earthquake was felt with an intensity of VII-VIII in the Puntarenas and Nicoya Peninsulas, in an area between Liberia, Cañas, Puntarenas, Cabo Blanco, Carrillo, Garza, Sardinal, and Tamarindo in Guanacaste; Nicoya city being the place where the maximum reported intensity of VIII is most notable. An intensity of VIII indicates that damage estimates are moderate to severe, and intensity VII indicates that damage estimates are moderate. According to the National Emergency Commission of Costa Rica, 371 affected communities were reported; most

  2. The Lyα luminosity function at z = 5.7 - 6.6 and the steep drop of the faint end: implications for reionization

    NASA Astrophysics Data System (ADS)

    Santos, Sérgio; Sobral, David; Matthee, Jorryt

    2016-08-01

    We present new results from the widest narrow band survey search for Lyα emitters at z = 5.7, just after reionization. We survey a total of 7 deg2 spread over the COSMOS, UDS and SA22 fields. We find over 11,000 line emitters, out of which 514 are robust Lyα candidates at z = 5.7 within a volume of 6.3 × 106 Mpc3. Our Lyα emitters span a wide range in Lyα luminosities, from faint to bright (LLyα ˜ 1042.5 - 44 erg s-1) and rest-frame equivalent widths (EW0 ˜ 25 - 1000 Å) in a single, homogeneous data-set. By combining all our fields we find that the faint end slope of the z = 5.7 Lyα luminosity function is very steep, with α =-2.3^{+0.4}_{-0.3}. We also present an updated z = 6.6 Lyα luminosity function, based on comparable volumes and obtained with the same methods, which we directly compare with that at z = 5.7. We find a significant decline of the number density of faint Lyα emitters from z = 5.7 to z = 6.6 (by 0.5 ± 0.1 dex), but no evolution at the bright end/no evolution in L★. Faint Lyα emitters at z = 6.6 show much more extended haloes than those at z = 5.7, suggesting that neutral Hydrogen plays an important role, increasing the scattering and leading to observations missing faint Lyα emission within the epoch of reionization. All together, our results suggest that we are observing patchy reionization which happens first around the brightest Lyα emitters, allowing the number densities of those sources to remain unaffected by the increase of neutral Hydrogen fraction from z ˜ 5 to z ˜ 7.

  3. The Petrographic Analysis of Yucatan Shelf Sequence in UNAM-5, 6 and 7 Wells

    NASA Astrophysics Data System (ADS)

    Nieto, A. O.; Fucugauchi, J. U.

    2013-05-01

    We present the initial results of a stratigraphic, X-ray diffraction and petrographic study of the Cenozoic carbonate sequence in the Yucatan's shelf. The sequence is studied in cores from the UNAM-5, UNAM-6 and UNAM-7 boreholes, which are located in the southwest and southern sectors of the Yucatan state, close to the Ticul Sierra. The Yucatán shelf is an area of scientific interest because beneath the Cenozoic sedimentary deposits there is crater impact of 180-200 km diameter, which formed 65.5 Ma ago. The Yucatan shelf has been characterized to be a shallow ramp shelf that is tectonically stable and has a Cenozoic continuous sedimentary record. With the aim of investigating the nature, stratigraphic relations, textural changes and identify possible events that occurred along the Cenozoic record. Using macroscopic descriptions, we performed detailed stratigraphic columns for the three borehole cores and prepared samples collected across stratigraphic columns for the petrography and the clays identification. The petrographic studies were made at different depths above the K/Pg boundary and whit the aim of recognize the textural variations, and the skeletal content, the identification of dolomite was made by the method of staining thin sections. Analysis of microfacies associations followed the criteria in facies belts Wilson 1975 for carbonate rimmed platforms, using and comparing, while the ramp carbonate microfacies type of Flügel 2009 to homoclinal carbonate ramp platform. The method of X-ray diffraction was used to identify clay types. Three boreholes contain the K/Pg boundary at different depths that correspond to a sequence, from bottom to top of limestone with evaporites nodules, clay content identified as illite-esmectite, little content of benthic, scarce planktic foraminifera and oogonia fossils that correspond to lagoon zone. This sequence is underlying limestones with different degrees of dolomitization that in many cases destroyed all fossils

  4. Ring Puckering Potentials of Three Fluorinated Cyclopentenes: C_5F_8, C_5HF_7, and C_5H_2F_6

    NASA Astrophysics Data System (ADS)

    Arsenault, E. A.; Long, B. E.; Pringle, Wallace C.; Choi, Yoon Jeong; Cooke, S. A.; Ocola, Esther J.; Laane, Jaan

    2015-06-01

    A systematic study on the ring puckering potentials of three fluorinated cyclopentenes has been performed using Fourier transform microwave spectroscopy in tandem with quantum chemical calculations. Spectra between 8 GHz and 16 GHz have been measured for octafluorocyclopentene, 1H-heptafluorocyclopentene, and 1H,2H-hexafluorocyclopentene, where the hydrogens sequentially replace the fluorines on the sp^2 hybridized carbons. Rotational constants and centrifugal distortion constants have been determined for the parent species and all 13C isotopologues. In regards to the ring puckering, double minimum potential, both cross state and intra-state transitions were observed for all molecules except the 1H,2H-hexafluorocyclopentene. Experimental Coriolis coupling constants and ΔE01 values will be presented and discussed. The ring puckering barrier heights for C_5F_8, C_5HF_7, and C_5H_2F_6, have been calculated to be 222 wn, 302 wn, and 367 wn, respectively.

  5. Estimation of doses to Taikonauts in SZ-5/6/7 missions using a male voxel model

    NASA Astrophysics Data System (ADS)

    Xu, Feng; Zeng, Zhi; Jia, Xianghong

    2011-11-01

    Objective To assess the Taikonaut's space radiation risk organ, doses have been calculated using a male voxel model. Methods A male voxel model based on MRI was built. The proton spectra were calculated by AP-8 with SPENVIS and Badhwar's GCR model. The general 3 D Monte Carlo particle and heavy ion transport code GEANT4 was used to calculate the average doses for some organs and tissues. Results After 1 g/cm2 shielding shell, the absorbed dose rate of skin is 0.6 mGy/d and effective dose rate is estimated to be 2.3 mSv/d during the SZ-5/6/7 mission. The total effective dosesof the taikonauts are estimated to be around 2.0 mSv during the SZ-5 mission, 10.9mSv during the SZ-6 mission and 6.5 mSv during the SZ-7 mission separately. Conclusion The calculated skin doses are closed to the values measured by TLDs in SZ-5/6/7, and within the range of 0.2~0.6mSv published by USA and Russia.

  6. Estimation of doses to Taikonauts in SZ-5/6/7 missions using a male voxel model

    NASA Astrophysics Data System (ADS)

    Xu, Feng; Zeng, Zhi; Jia, Xianghong

    2012-03-01

    Objective To assess the Taikonaut's space radiation risk organ, doses have been calculated using a male voxel model. Methods A male voxel model based on MRI was built. The proton spectra were calculated by AP-8 with SPENVIS and Badhwar's GCR model. The general 3 D Monte Carlo particle and heavy ion transport code GEANT4 was used to calculate the average doses for some organs and tissues. Results After 1 g/cm2 shielding shell, the absorbed dose rate of skin is 0.6 mGy/d and effective dose rate is estimated to be 2.3 mSv/d during the SZ-5/6/7 mission. The total effective dosesof the taikonauts are estimated to be around 2.0 mSv during the SZ-5 mission, 10.9mSv during the SZ-6 mission and 6.5 mSv during the SZ-7 mission separately. Conclusion The calculated skin doses are closed to the values measured by TLDs in SZ-5/6/7, and within the range of 0.2~0.6mSv published by USA and Russia.

  7. 5,7-Bis(2'-arylethenyl)-6H-1,4-diazepine-2,3-dicarbonitriles: synthesis, and experimental and theoretical evaluation of the effects of substituents at 5,6,7-positions on the molecular configuration and spectral properties.

    PubMed

    Tarakanov, Pavel A; Simakov, Anton O; Dzuban, Alexander V; Shestov, Vladimir I; Tarakanova, Ekaterina N; Pushkarev, Victor E; Tomilova, Larisa G

    2016-01-21

    A series of novel 5,7-bis(2'-arylethenyl)-6H-1,4-diazepine-2,3-dicarbonitriles was synthesized through sequential aldol condensation reactions of 1,3-diketones with diaminomaleonitrile, and the resulting 5,7-dimethyl-6H-1,4-diazepines were condensed with aromatic aldehydes. The substituents' effects on the spectral properties and conformational states of the molecules in solution were studied using 2D NMR techniques and DFT calculations. Specific intramolecular steric interactions in derivatives substituted at the C6 position were discovered and investigated in detail. Differential scanning calorimetry and thermogravimetric analyses revealed the strong dependence of the thermal stability of the newly prepared diazepinodicarbonitriles on the nature of the substituents. This offers new insight into the structure-property relationships of arylethenyl-substituted diazepine derivatives. PMID:26646741

  8. Light curve analysis for eclipsing systems with exoplanets. The systems Kepler-5b, Kepler-6b, and Kepler-7b

    NASA Astrophysics Data System (ADS)

    Gostev, N. Yu.

    2011-07-01

    High-accuracy light curves for the binaries with exoplanets Kepler-5b, Kepler-6b, and Kepler-7b have been analyzed. The radii of the stars and the planets and the orbital inclinations of the binaries are derived. Reliable estimates of the linear and quadratic limb-darkening coefficients and their confidence intervals (uncertainties) are presented.

  9. 21 CFR 73.3119 - 7,16-Dichloro-6,15-dihydro-5,9,14,18-anthrazinetetrone.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 1 2012-04-01 2012-04-01 false 7,16-Dichloro-6,15-dihydro-5,9,14,18-anthrazinetetrone. 73.3119 Section 73.3119 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION Medical Devices § 73.3119...

  10. 21 CFR 73.3119 - 7,16-Dichloro-6,15-dihydro-5,9,14,18-anthrazinetetrone.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 1 2013-04-01 2013-04-01 false 7,16-Dichloro-6,15-dihydro-5,9,14,18-anthrazinetetrone. 73.3119 Section 73.3119 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION Medical Devices § 73.3119...

  11. Role of endogenous TRPC6 channels in Ca2+ signal generation in A7r5 smooth muscle cells.

    PubMed

    Soboloff, Jonathan; Spassova, Maria; Xu, Wen; He, Li-Ping; Cuesta, Natalia; Gill, Donald L

    2005-12-01

    The ubiquitously expressed canonical transient receptor potential (TRPC) ion channels are considered important in Ca2+ signal generation, but their mechanisms of activation and roles remain elusive. Whereas most studies have examined overexpressed TRPC channels, we used molecular, biochemical, and electrophysiological approaches to assess the expression and function of endogenous TRPC channels in A7r5 smooth muscle cells. Real time PCR and Western analyses reveal TRPC6 as the only member of the diacylglycerol-responsive TRPC3/6/7 subfamily of channels expressed at significant levels in A7r5 cells. TRPC1, TRPC4, and TRPC5 were also abundant. An outwardly rectifying, nonselective cation current was activated by phospholipase C-coupled vasopressin receptor activation or by the diacylglycerol analogue, oleoyl-2-acetyl-sn-glycerol (OAG). Introduction of TRPC6 small interfering RNA sequences into A7r5 cells by electroporation led to 90% reduction of TRPC6 transcript and 80% reduction of TRPC6 protein without any detectable compensatory changes in the expression of other TRPC channels. The OAG-activated nonselective cation current was similarly reduced by TRPC6 RNA interference. Intracellular Ca2+ measurements using fura-2 revealed that thapsigargin-induced store-operated Ca2+ entry was unaffected by TRPC6 knockdown, whereas vasopressin-induced Ca2+ entry was suppressed by more than 50%. In contrast, OAG-induced Ca2+ transients were unaffected by TRPC6 knockdown. Nevertheless, OAG-induced Ca2+ entry bore the hallmarks of TRPC6 function; it was inhibited by protein kinase C and blocked by the Src-kinase inhibitor, 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2). Importantly, OAG-induced Ca2+ entry was blocked by the potent L-type Ca2+ channel inhibitor, *nimodipine. Thus, TRPC6 activation probably results primarily in Na ion entry and depolarization, leading to activation of L-type channels as the mediators of Ca2+ entry. Calculations reveal that even

  12. Identification of a major IP5 kinase in Cryptococcus neoformans confirms that PP-IP5/IP7, not IP6, is essential for virulence

    PubMed Central

    Li, Cecilia; Lev, Sophie; Saiardi, Adolfo; Desmarini, Desmarini; Sorrell, Tania C.; Djordjevic, Julianne T.

    2016-01-01

    Fungal inositol polyphosphate (IP) kinases catalyse phosphorylation of IP3 to inositol pyrophosphate, PP-IP5/IP7, which is essential for virulence of Cryptococcus neoformans. Cryptococcal Kcs1 converts IP6 to PP-IP5/IP7, but the kinase converting IP5 to IP6 is unknown. Deletion of a putative IP5 kinase-encoding gene (IPK1) alone (ipk1Δ), and in combination with KCS1 (ipk1Δkcs1Δ), profoundly reduced virulence in mice. However, deletion of KCS1 and IPK1 had a greater impact on virulence attenuation than that of IPK1 alone. ipk1Δkcs1Δ and kcs1Δ lung burdens were also lower than those of ipk1Δ. Unlike ipk1Δ, ipk1Δkcs1Δ and kcs1Δ failed to disseminate to the brain. IP profiling confirmed Ipk1 as the major IP5 kinase in C. neoformans: ipk1Δ produced no IP6 or PP-IP5/IP7 and, in contrast to ipk1Δkcs1Δ, accumulated IP5 and its pyrophosphorylated PP-IP4 derivative. Kcs1 is therefore a dual specificity (IP5 and IP6) kinase producing PP-IP4 and PP-IP5/IP7. All mutants were similarly attenuated in virulence phenotypes including laccase, urease and growth under oxidative/nitrosative stress. Alternative carbon source utilisation was also reduced significantly in all mutants except ipk1Δ, suggesting that PP-IP4 partially compensates for absent PP-IP5/IP7 in ipk1Δ grown under this condition. In conclusion, PP-IP5/IP7, not IP6, is essential for fungal virulence. PMID:27033523

  13. Identification of a major IP5 kinase in Cryptococcus neoformans confirms that PP-IP5/IP7, not IP6, is essential for virulence.

    PubMed

    Li, Cecilia; Lev, Sophie; Saiardi, Adolfo; Desmarini, Desmarini; Sorrell, Tania C; Djordjevic, Julianne T

    2016-01-01

    Fungal inositol polyphosphate (IP) kinases catalyse phosphorylation of IP3 to inositol pyrophosphate, PP-IP5/IP7, which is essential for virulence of Cryptococcus neoformans. Cryptococcal Kcs1 converts IP6 to PP-IP5/IP7, but the kinase converting IP5 to IP6 is unknown. Deletion of a putative IP5 kinase-encoding gene (IPK1) alone (ipk1Δ), and in combination with KCS1 (ipk1Δkcs1Δ), profoundly reduced virulence in mice. However, deletion of KCS1 and IPK1 had a greater impact on virulence attenuation than that of IPK1 alone. ipk1Δkcs1Δ and kcs1Δ lung burdens were also lower than those of ipk1Δ. Unlike ipk1Δ, ipk1Δkcs1Δ and kcs1Δ failed to disseminate to the brain. IP profiling confirmed Ipk1 as the major IP5 kinase in C. neoformans: ipk1Δ produced no IP6 or PP-IP5/IP7 and, in contrast to ipk1Δkcs1Δ, accumulated IP5 and its pyrophosphorylated PP-IP4 derivative. Kcs1 is therefore a dual specificity (IP5 and IP6) kinase producing PP-IP4 and PP-IP5/IP7. All mutants were similarly attenuated in virulence phenotypes including laccase, urease and growth under oxidative/nitrosative stress. Alternative carbon source utilisation was also reduced significantly in all mutants except ipk1Δ, suggesting that PP-IP4 partially compensates for absent PP-IP5/IP7 in ipk1Δ grown under this condition. In conclusion, PP-IP5/IP7, not IP6, is essential for fungal virulence. PMID:27033523

  14. Reactions of vitamin E and its model compound 2,2,5,7,8-pentamethylchroman-6-ol with ozone

    SciTech Connect

    Liebler, D.C.; Matsumoto, Shigenobu; Matsuo, Mitsuyoshi; Iitaka, Yoichi

    1993-01-01

    Reaction of vitamin E [(R,R,R,)-{alpha}-tocopherol] with ozone in acetonitrile yielded {alpha}-tocopheryl quinone and its precursor 8{alpha}-hydroxytocopherone, which accounted for approximately 30% of the products at <50% {alpha}-tocopherol oxidation. In addition, two novel products were identified as epimers of 10-acetyl-7-(4{prime},8{prime},12{prime}-trimethyl tridecyl)-3,4,7-trimethyl-2-oxo - 1,6-dioxaspiro[4.5]-deca-3,9-diene. These spiro products were formed in equal amounts in a combined yield of approximately 33% after complete {alpha}-tocpherol oxidation. Ozonation of the vitamin E model compound 2,2,5,7,8-pentamethylchroman-6-ol yielded an analogous spiro product, 10-acetyl-3,4,7,7-tetramethyl-2-oxo-1,6-dioxaspiro[4.5]deca-3,9-diene, whose structure was confirmed by X-ray crystallography. The spiro products may be formed by ozone addition to the chroman ring and subsequent rearrangement to ring-opened hydroxyacid products, which yield spiro products by ring closure due to dehydration. Novel spiro products formed by ozonation of vitamin E may be unique markers of ozone interaction with lipid structures that contain vitamin E. 39 refs., 3 figs., 1 tab.

  15. 2-(Alkylamino)-3-aryl-6,7-dihydrobenzofuran-4(5H)-ones: Improved Synthesis and their Photophysical Properties

    PubMed Central

    Kumar, Manoj; Kumawat, Lokesh Kumar; Gupta, Vinod Kumar; Sharma, Anuj

    2015-01-01

    Furans are an important class of compounds and exhibit a diverse range of activities and properties. As such, improved synthetic access to furans is an important research goal. In the present report, a solvent- and catalyst-free reaction between 5,5-dimethyl-1,3-cyclohexanedione (dimedone), an aryl aldehyde and an isocyanide under microwave irradiation is presented. This method is significantly improved from previously described protocols in terms of applicability of wide ranging aryl aldehydes, better yields, shorter reaction times, facile work up and essentially no need of column chromatography. The photophysical properties of this series of compounds were studied for their possible applicability in the field of metal ion sensors. In solution, two compounds, 2-(cyclohexylamino)-3-(1H-indol-3-yl)-6,6-dimethyl-6,7-dihydrobenzofuran-4(5H)-one (1 i) and 2-(tert-butylamino)-3-(1H-indol-3-yl)-6,6-dimethyl-6,7-dihydrobenzofuran-4(5H)-one (1 j), underwent an observable color change from yellow to colorless in the presence of aluminum(III) ions. Further studies to investigate the UV absorption and luminescence behavior of these compounds revealed their utility as “naked-eye sensors” for aluminum detection. PMID:26491643

  16. Biochemical and Structural Studies of 6-Carboxy-5,6,7,8-tetrahydropterin Synthase Reveal the Molecular Basis of Catalytic Promiscuity within the Tunnel-fold Superfamily*

    PubMed Central

    Miles, Zachary D.; Roberts, Sue A.; McCarty, Reid M.; Bandarian, Vahe

    2014-01-01

    6-Pyruvoyltetrahydropterin synthase (PTPS) homologs in both mammals and bacteria catalyze distinct reactions using the same 7,8-dihydroneopterin triphosphate substrate. The mammalian enzyme converts 7,8-dihydroneopterin triphosphate to 6-pyruvoyltetrahydropterin, whereas the bacterial enzyme catalyzes the formation of 6-carboxy-5,6,7,8-tetrahydropterin. To understand the basis for the differential activities we determined the crystal structure of a bacterial PTPS homolog in the presence and absence of various ligands. Comparison to mammalian structures revealed that although the active sites are nearly structurally identical, the bacterial enzyme houses a His/Asp dyad that is absent from the mammalian protein. Steady state and time-resolved kinetic analysis of the reaction catalyzed by the bacterial homolog revealed that these residues are responsible for the catalytic divergence. This study demonstrates how small variations in the active site can lead to the emergence of new functions in existing protein folds. PMID:24990950

  17. Genomic and Functional Analyses of Rhodococcus equi Phages ReqiPepy6, ReqiPoco6, ReqiPine5, and ReqiDocB7

    PubMed Central

    Summer, E. J.; Liu, M.; Gill, J. J.; Grant, M.; Chan-Cortes, T. N.; Ferguson, L.; Janes, C.; Lange, K.; Bertoli, M.; Moore, C.; Orchard, R. C.; Cohen, N. D.; Young, R.

    2011-01-01

    The isolation and results of genomic and functional analyses of Rhodococcus equi phages ReqiPepy6, ReqiDocB7, ReqiPine5, and ReqiPoco6 (hereafter referred to as Pepy6, DocB7, Pine5, and Poco6, respectively) are reported. Two phages, Pepy6 and Poco6, more than 75% identical, exhibited genome organization and protein sequence likeness to Lactococcus lactis phage 1706 and clostridial prophage elements. An unusually high fraction, 27%, of Pepy6 and Poco6 proteins were predicted to possess at least one transmembrane domain, a value much higher than the average of 8.5% transmembrane domain-containing proteins determined from a data set of 36,324 phage protein entries. Genome organization and protein sequence comparisons place phage Pine5 as the first nonmycobacteriophage member of the large Rosebush cluster. DocB7, which had the broadest host range among the four isolates, was not closely related to any phage or prophage in the database, and only 23 of 105 predicted encoded proteins could be assigned a functional annotation. Because of the relationship of Rhodococcus to Mycobacterium, it was anticipated that these phages should exhibit some of the features characteristic of mycobacteriophages. Traits that were identified as shared by the Rhodococcus phages and mycobacteriophages include the prevalent long-tailed morphology and the presence of genes encoding LysB-like mycolate-hydrolyzing lysis proteins. Application of DocB7 lysates to soils amended with a host strain of R. equi reduced recoverable bacterial CFU, suggesting that phage may be useful in limiting R. equi load in the environment while foals are susceptible to infection. PMID:21097585

  18. Design, Synthesis and Biological Evaluation of 5-Oxo-1,4,5,6,7,8 Hexahydroquinoline Derivatives as Selective Cyclooxygenase-2 Inhibitors

    PubMed Central

    Zarghi, Afshin; Sabakhi, Iman; Topuzyan, Vigen; Hajimahdi, Zahra; Daraie, Bahram

    2014-01-01

    A group of regioisomeric 5-oxo-1,4,5,6,7,8 hexahydroquinoline derivatives possessing a COX-2 SO2Me pharmacophore at the para position of the C-2 or C-4 phenyl ring, in conjunction with a C-4 or C-2 phenyl (4-H) or substituted-phenyl ring (4-F,4-Cl,4-Br,4-OMe,4-Me, 4-NO2), were designed for evaluation as selective cyclooxygenase-2 (COX-2) inhibitors. These target 5-oxo-1,4,5,6,7,8 hexahydroquinolines were synthesized via a Hansch condensation reaction. In vitro COX-1/COX-2 isozyme inhibition structure-activity studies identified 7,8-dihydro- 7,7-dimethyl-2-(4-methoxyphenyl)-4-(4-(methylsulfonyl)phenyl)quinolin-5(1H,4H,6H)- one (9c) as a potent COX-2 inhibitor (IC50 = 0.17 M) with a high COX-2 selectivity index (S.I. = 97.6) comparable to the reference drug celecoxib (COX-2 IC50 = 0.05 mM; COX-2 S.I= 405). A molecular modeling study where 9c was docked in active site of COX-2 showed that the p-SO2Me substituent on the C-2 phenyl ring is inserted into the secondary COX-2 binding site. The structure activity data acquired indicate that the position of the COX-2 SO2Me pharmacophore and type of substituent are important for COX-2 inhibitory activity. PMID:24711830

  19. Synthesis and anticancer activities of 5,6,7-trimethoxy-N-phenyl(ethyl)-4-aminoquinazoline derivatives.

    PubMed

    Zhang, Ying; Jin, Linhong; Xiang, Hongmei; Wu, Jian; Wang, Peiyi; Hu, Deyu; Xue, Wei; Yang, Song

    2013-08-01

    A series of 5,6,7-trimethoxy-N-phenyl(ethyl)-4-aminoquinazoline compounds was prepared by microwave irradiation and conventional heating methods. Compounds 6p, 6q, and 6x strongly inhibited extracellular regulated kinase1/2 (ERK1/2) phosphorylation induced by epidermal growth factor (EGF) at 1.28 μM in PC3 cells. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay showed that all compounds had certain anticancer activities, and the IC₅₀ values of 6x were 6.2 ± 0.9, 3.2 ± 0.1, and 3.1 ± 0.1 μM against PC3, BGC823, and Bcap37 cells, respectively. Acridine orange/ethidium bromide staining, Hoechst 33258 staining, DNA ladder, and flow cytometry analyses revealed that 6x induced cell apoptosis in PC3 cells, with apoptosis ratios of 11.6% at 1 μM and 31.8% at 10 μM after 72 h. PMID:23811258

  20. The thermodynamic properties of 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene

    SciTech Connect

    Chirico, R.D.; Knipmeyer, S.E.; Nguyen, A.; Smith, N.K.; Steele, W.V.

    1992-12-01

    Measurements leading to the calculation of the ideal-gas thermodynamic properties are reported for 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene. Experimental methods included combustion calorimetry, adiabatic heat-capacity calorimetry, vibrating-tube densitometry, comparative ebulliometry, inclined-piston gauge manometry, and differential-scanning calorimetry (d.s.c.). Critical properties were estimated for both materials based on the measurement results. Entropies, enthalpies, and Gibbs energies of formation were derived for the ideal gases for selected temperatures between 380 K and 700 K. The property-measurement results reported here for 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene are the first for these important intermediates in the pyrene/H{sub 2} hydrogenation reaction network.

  1. Euphorikanin A, a Diterpenoid Lactone with a Fused 5/6/7/3 Ring System from Euphorbia kansui.

    PubMed

    Fei, Dong-Qing; Dong, Le-Le; Qi, Feng-Ming; Fan, Gai-Xia; Li, Hui-Hong; Li, Zheng-Yu; Zhang, Zhan-Xin

    2016-06-17

    Euphorikanin A (1), an unprecedented diterpenoid lactone which possesses a novel 5/6/7/3-fused tetracyclic ring skeleton, was isolated from the roots of Euphorbia kansui. The chemical structure and absolute stereochemistry were elucidated on the basis of extensive spectroscopic methods and single-crystal X-ray diffraction analysis. Compound 1 exhibited moderate cytotoxicity against two human tumor cell lines HeLa and NCI-446. A proposed biosynthetic pathway of compound 1 is also described. PMID:27230557

  2. Sodium potassium hydrogen citrate, NaKHC6H5O7.

    PubMed

    Rammohan, Alagappa; Kaduk, James A

    2016-02-01

    The crystal structure of sodium potassium hydrogen citrate has been solved and refined using laboratory X-ray powder diffraction data, and optimized using density functional theory techniques. The Na(+) cation is six-coordinate, with a bond-valence sum of 1.17. The K(+) cation is also six-coordinate, with a bond-valence sum of 1.08. The distorted [NaO6] octahedra share edges, forming chains along the a axis. The likewise distorted [KO6] octahedra share edges with the [NaO6] octahedra on either side of the chain, and share corners with other [KO6] octahedra, resulting in triple chains along the a axis. The most prominent feature of the structure is the chain along [111] of very short, very strong hydrogen bonds; the O⋯O distances are 2.414 and 2.400 Å. The Mulliken overlap populations in these hydrogen bonds are 0.138 and 0.142 e, which correspond to hydrogen-bond energies of 20.3 and 20.6 kcal mol(-1). PMID:26958380

  3. Sodium potassium hydrogen citrate, NaKHC6H5O7

    PubMed Central

    Rammohan, Alagappa; Kaduk, James A.

    2016-01-01

    The crystal structure of sodium potassium hydrogen citrate has been solved and refined using laboratory X-ray powder diffraction data, and optimized using density functional theory techniques. The Na+ cation is six-coordinate, with a bond-valence sum of 1.17. The K+ cation is also six-coordinate, with a bond-valence sum of 1.08. The distorted [NaO6] octahedra share edges, forming chains along the a axis. The likewise distorted [KO6] octahedra share edges with the [NaO6] octahedra on either side of the chain, and share corners with other [KO6] octahedra, resulting in triple chains along the a axis. The most prominent feature of the structure is the chain along [111] of very short, very strong hydrogen bonds; the O⋯O distances are 2.414 and 2.400 Å. The Mulliken overlap populations in these hydrogen bonds are 0.138 and 0.142 e, which correspond to hydrogen-bond energies of 20.3 and 20.6 kcal mol−1. PMID:26958380

  4. 3,3,6,6,9,9-Hexaethyl-1,2,4,5,7,8-hexaoxacyclononane at 296 K.

    PubMed

    Cerna, Jorge; Bernès, Sylvain; Cañizo, Adriana; Eyler, Nora

    2009-11-01

    The title molecule (diethyl ketone triperoxide, DEKTP), C(15)H(30)O(6), is a cyclic triperoxide closely related to triacetone triperoxide (TATP), one of the most unstable explosives known. However, the stability of DEKTP is ca 20-50 times greater than that of TATP. DEKTP crystallizes with two molecules in the asymmetric unit, with virtually identical geometry. The cyclononane core is stabilized in a twisted boat-chair conformation (approximate D(3) symmetry), very close to that previously described for TATP. The explanation for the safe thermal behaviour of DEKTP compared with TATP should thus not be sought in the molecular dimensions, but rather in the thermal decomposition kinetics. PMID:19893236

  5. Comprehensive Synthesis of Monohydroxy-Cucurbit[n]urils (n = 5, 6, 7, 8): High Purity and High Conversions.

    PubMed

    Ayhan, Mehmet M; Karoui, Hakim; Hardy, Micaël; Rockenbauer, Antal; Charles, Laurence; Rosas, Roselyne; Udachin, Konstantin; Tordo, Paul; Bardelang, David; Ouari, Olivier

    2015-08-19

    We describe a photochemical method to introduce a single alcohol function directly on cucurbit[n]urils (n = 5, 6, 7, 8) with conversions of the order 95-100% using hydrogen peroxide and UV light. The reaction was easily scaled up to 1 g for CB[6] and CB[7]. Spin trapping of cucurbituril radicals combined with MS experiments allowed us to get insights about the reaction mechanism and characterize CB[5], CB[6], CB[7], and CB[8] monofunctional compounds. Experiments involving (18)O isotopically labeled water indicated that the mechanism was complex and showed signs of both radical and ionic intermediates. DFT calculations allowed estimating the Bond Dissociation Energies (BDEs) of each hydrogen atom type in the CB series, providing an explanation of the higher reactivity of the "equatorial" C-H position of CB[n] compounds. These results also showed that, for CB[8], direct functionalization on the cucurbituril skeleton is more difficult because one of the methylene hydrogen atoms (Hb) has its BDE lowering within the series and coming close to that of Hc, thus opening the way to other types of free radicals generated on the CB[8] skeleton leading to several side products. Yet CB[5]-(OH)1 and CB[8]-(OH)1, the first CB[8] derivative, were obtained in excellent yields thanks to the soft method presented here. PMID:26197228

  6. Happiness is 0 to 6 from 7 to 5: Coosa Valley's Child Development Program

    ERIC Educational Resources Information Center

    Appalachia, 1973

    1973-01-01

    The Carterville and Calhoun centers are representative of the 6 local child development programs in rural northwest Georgia. The day care centers are for the children of working mothers. The outreach program provides workers who go into the homes to help nonworking mothers improve their child-rearing skills. (FF)

  7. 2-Amino-6-methyl-4,5,6,7-tetra-hydro-1-benzothio-phene-3-carbonitrile.

    PubMed

    Ziaulla, Mohamed; Banu, Afshan; Begum, Noor Shahina; Panchamukhi, Shridhar I; Khazi, I M

    2011-01-01

    In the title compound, C(10)H(12)N(2)S, one of the C atoms of the cyclo-hexene ring (at position 6) and the methyl group attached to it are disordered over two sets of sites in a 0.650 (3):0.350 (3) ratio. The cyclo-hexene ring in both the major and minor occupancy conformers adopts a half-chair conformation. The thio-phene ring is essentially planar (r.m.s. deviation = 0.05 Å). In the crystal, N-H⋯N hydrogen bonds involving the amino groups result in inversion dimers with R(2) (2)(12) graph-set motif. Further N-H⋯N hydrogen bonds involving the amino and carbonitrile groups generate zigzag chains along the a axis. PMID:21522444

  8. Antireflection coating on germanium for dual channel (3-5 and 7.5-10.6 μm) thermal imagers

    NASA Astrophysics Data System (ADS)

    Ghosh, A.; Kant, P.; Bandyopadhyay, P. K.; Chandra, P.; Nijhawan, O. P.

    1999-02-01

    The dual channel thermal imager, operating in the 3-5 and 7.5-10.6 μm wavelength bands, is one of the latest achievements in instrumentation for target recognition and acquisition. While the 3-5 μm band is utilised for detecting hot objects such as engine exhausts of vehicles and fighter planes, the 7.5-10.6 μm band is employed for human bodies and objects at ambient temperatures. Many substrates are available which transmit in both these wavelength bands and their transmission can be enhanced by providing a suitable antireflection coating. In this paper, a broad band antireflection coating on germanium substrate is reported. The design approach involves achieving a continuously varying refractive index from that of the incident medium to the substrate. The continuously varying refractive index profile may be generated by using a sequence of thin layers of high and low refractive index materials. In this design a continuous refractive index profile is approximated by using a 13-layer stack of thorium fluoride and germanium as low and high index coating materials respectively. This coating conforms to environmental stability standards and shows an average transmission of 91% in 3-5 μm band and 94.5% in 7.5-10.6 μm band with a peak of 97% at 9 μm on 10 mm thick germanium substrate. Polycrystalline germanium has 2.5% absorption for a 10 mm thick substrate.

  9. Reduced Condensing and Ordering Effects by 7-Ketocholesterol and 5β,6β-Epoxycholesterol on DPPC Monolayers.

    PubMed

    Telesford, Dana-Marie; Verreault, Dominique; Reick-Mitrisin, Victoria; Allen, Heather C

    2015-09-15

    The exposure of organic-coated marine aerosols containing cholesterol (Chol) to radiation and/or an oxidizing atmosphere results in the formation of oxidized derivatives or oxysterols and will likely change aerosol surface properties. However, the intermolecular interactions between oxysterols and other lipid components and their influence on the surface properties of marine aerosols are not well-known. To address this question, the interfacial behavior and domain morphology of model Langmuir monolayers of two ring-substituted oxysterols, 7-ketocholesterol (7-KChol) and 5β,6β-epoxycholesterol (5,6β-EChol), mixed with 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) were investigated by means of compression isotherms and Brewster angle microscopy (BAM) over a broad range of surface pressures and sterol molar ratios. Mixed DPPC/cholesterol (Chol) monolayers were also measured for comparison. The results of compression experiments showed that the condensing effect induced on mixed DPPC/sterol monolayers at low surface pressures and for intermediate molar ratios (0.3 ≤ X(sterol) ≤ 0.7) was weaker for oxysterols than for Chol. Additionally, mixed DPPC/oxysterol monolayers exhibited markedly smaller (∼2-3-fold) interfacial rigidity. Examination of the excess free energy of mixing further revealed that DPPC monolayers containing 7-KChol and Chol were thermodynamically more stable at high surface pressures than those with 5,6β-EChol, indicating that the strength of interactions between DPPC and 5,6β-EChol was the smallest. Finally, BAM images in the LE-LC phase of DPPC revealed that in comparison to Chol the addition of small amounts of oxysterols results in larger and less numerous domains, showing that oxysterols are not as effective in fluidizing the condensed phase of DPPC. Taken together, these results suggest that the strength of van der Waals interactions of DPPC alkyl chains with sterols follows the sterol hydrophobicity, with Chol being the most

  10. Design, synthesis and antitrypanosomal activities of 2,6-disubstituted-4,5,7-trifluorobenzothiophenes.

    PubMed

    Bhambra, Avninder S; Edgar, Mark; Elsegood, Mark R J; Li, Yuqi; Weaver, George W; Arroo, Randolph R J; Yardley, Vanessa; Burrell-Saward, Hollie; Krystof, Vladimir

    2016-01-27

    Current treatments for Human African Trypanosomiasis (HAT) are limited in their application, have undesirable dosing regimens and unsatisfactory toxicities highlighting the need for the development of a safer drug pipeline. Our medicinal chemistry programme in developing rapidly accessible and modifiable heterocyclic scaffolds led to the design and synthesis of novel substituted benzothiophenes, with 6-benzimidazol-1-ylbenzothiophene derivatives demonstrating significant antitrypanosomal activities (IC50 < 1 μM) against Trypanosoma brucei rhodesiense and no toxicity towards mammalian cells. PMID:26698538

  11. Cytotoxic, Antiproliferative and Pro-Apoptotic Effects of 5-Hydroxyl-6,7,3′,4′,5′-Pentamethoxyflavone Isolated from Lantana ukambensis

    PubMed Central

    Sawadogo, Wamtinga Richard; Cerella, Claudia; Al-Mourabit, Ali; Moriou, Céline; Teiten, Marie-Hélène; Guissou, Innocent Pierre; Dicato, Mario; Diederich, Marc

    2015-01-01

    Lantana ukambensis (Vatke) Verdc. is an African food and medicinal plant. Its red fruits are eaten and highly appreciated by the rural population. This plant was extensively used in African folk medicinal traditions to treat chronic wounds but also as anti-leishmanial or cytotoxic remedies, especially in Burkina Faso, Tanzania, Kenya, or Ethiopia. This study investigates the in vitro bioactivity of polymethoxyflavones extracted from a L. ukambensis as anti-proliferative and pro-apoptotic agents. We isolated two known polymethoxyflavones, 5,6,7,3′,4′,5′-hexamethoxyflavone (1) and 5-hydroxy-6,7,3′,4′,5′-pentamethoxyflavone (2) from the whole plant of L. ukambensis. Their chemical structures were determined by spectroscopic analysis and comparison with published data. These molecules were tested for the anti-proliferative, cytotoxic and pro-apoptotic effects on human cancer cells. Among them, 5-hydroxy-6,7,3′,4′,5′-pentamethoxyflavone (2) was selectively cytotoxic against monocytic lymphoma (U937), acute T cell leukemia (Jurkat), and chronic myelogenous leukemia (K562) cell lines, but not against peripheral blood mononuclear cells (PBMCs) from healthy donors, at all tested concentrations. Moreover, this compound exhibited significant anti-proliferative and pro-apoptotic effects against U937 acute myelogenous leukemia cells. This study highlights the anti-proliferative and pro-apoptotic effects of 5-hydroxy-6,7,3′,4′,5′-pentamethoxyflavone (2) and provides a scientific basis of traditional use of L. ukambensis. PMID:26690473

  12. Passive standoff detection of SF6 at a distance of 5.7 km by differential Fourier transform infrared radiometry.

    PubMed

    Lavoie, Hugo; Puckrin, Eldon; Thériault, Jean-Marc; Bouffard, François

    2005-10-01

    Recent results are presented on the passive detection, identification, and quantification of a vapor cloud of SF6 measured at a horizontal standoff distance of 5.7 km using a dual-beam interferometer optimized for background signal suppression. The measurements were performed at Defense Research and Development Canada (DRDC)-Valcartier during a number of recent open-air experiments. The measurement approach is based on the differential passive standoff detection method that has been developed by DRDC Valcartier during the past few years. This work represents the first such measurement reported in the open literature for a standoff distance as large as 5.7 km. These results clearly demonstrate the capability of the differential radiometry approach to the detection, identification, and quantification of chemical vapor clouds located at long distances from the sensor. PMID:16274529

  13. New 2-phenyl-4,5,6,7-tetrahydro-2H-indazole derivatives as paddy field herbicides.

    PubMed

    Hwang, In Taek; Kim, Hyoung Rae; Jeon, Dong Ju; Hong, Kyung Sik; Song, Jong Hwan; Chung, Chang Kook; Cho, Kwang Yun

    2005-05-01

    A series of 3-chloro-2-(4-chloro-2-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazole derivatives containing various substituted isoxazolinylmethoxy groups at the 5-position of the benzene ring were synthesized and their herbicidal activities assessed under greenhouse and flooded paddy conditions. Among them, compounds having a phenyl or cyano substituent at the 3-position of the 5-methyl-isoxazolin-5-yl structure demonstrated good rice selectivity and potent herbicidal activity against annual weeds at 16-63 g AI ha(-1) under greenhouse conditions. Field trials indicated that these two compounds controlled a wide range of annual weeds rapidly with a good tolerance on transplanted rice seedlings by pre-emergence application. They showed a low mammalian and environmental toxicity in various toxicological tests. PMID:15627239

  14. The Identification of Z-dropouts in Pan-STARRS1: Three Quasars at 6.5< z< 6.7

    NASA Astrophysics Data System (ADS)

    Venemans, B. P.; Bañados, E.; Decarli, R.; Farina, E. P.; Walter, F.; Chambers, K. C.; Fan, X.; Rix, H.-W.; Schlafly, E.; McMahon, R. G.; Simcoe, R.; Stern, D.; Burgett, W. S.; Draper, P. W.; Flewelling, H.; Hodapp, K. W.; Kaiser, N.; Magnier, E. A.; Metcalfe, N.; Morgan, J. S.; Price, P. A.; Tonry, J. L.; Waters, C.; AlSayyad, Y.; Banerji, M.; Chen, S. S.; González-Solares, E. A.; Greiner, J.; Mazzucchelli, C.; McGreer, I.; Miller, D. R.; Reed, S.; Sullivan, P. W.

    2015-03-01

    Luminous distant quasars are unique probes of the high-redshift intergalactic medium (IGM) and of the growth of massive galaxies and black holes in the early universe. Absorption due to neutral hydrogen in the IGM makes quasars beyond a redshift of z≃ 6.5 very faint in the optical z band, thus locating quasars at higher redshifts requires large surveys that are sensitive above 1 micron. We report the discovery of three new z\\gt 6.5 quasars, corresponding to an age of the universe of \\lt 850 Myr, selected as z-band dropouts in the Pan-STARRS1 survey. This increases the number of known z\\gt 6.5 quasars from four to seven. The quasars have redshifts of z = 6.50, 6.52, and 6.66, and include the brightest z-dropout quasar reported to date, PSO J036.5078 + 03.0498 with {{M}1450}=-27.4. We obtained near-infrared spectroscopy for the quasars, and from the Mg ii line, we estimate that the central black holes have masses between 5 × 108 and 4 × 109 {{M}⊙ } and are accreting close to the Eddington limit ({{L}Bol}/{{L}Edd}=0.13-1.2). We investigate the ionized regions around the quasars and find near-zone radii of {{R}NZ}=1.5-5.2 proper Mpc, confirming the trend of decreasing near-zone sizes with increasing redshift found for quasars at 5.7\\lt z\\lt 6.4. By combining RNZ of the PS1 quasars with those of 5.7\\lt z\\lt 7.1 quasars in the literature, we derive a luminosity-corrected redshift evolution of {{R}NZ,corrected}=(7.2+/- 0.2)-(6.1+/- 0.7)× (z-6) Mpc. However, the large spread in RNZ in the new quasars implies a wide range in quasar ages and/or a large variation in the neutral hydrogen fraction along different lines of sight. Based in part on observations collected at the European Southern Observatory, Chile, programs 179.A-2010, 092.A-0150, 093.A-0863, and 093.A-0574, and at the Centro Astronómico Hispano Alemán (CAHA) at Calar Alto, operated jointly by the Max-Planck Institut für Astronomie and the Instituto de Astrofísica de Andalucía (CSIC). This paper

  15. Synthesis, structure-activity relationships and biological evaluation of 4,5,6,7-tetrahydropyrazolopyrazines as metabotropic glutamate receptor 5 negative allosteric modulators.

    PubMed

    Hirose, Wataru; Kato, Yoshihiro; Yamamoto, Takayoshi; Kassai, Momoe; Takata, Makoto; Hayashi, Shun; Arai, Yukiyo; Imai, Satoki; Yoshida, Kohzo

    2016-08-15

    The design, synthesis and SAR studies of novel 4,5,6,7-tetrahydropyrazolopyrazines as metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulators (NAMs) are presented in this letter. Starting from a HTS hit compound (1, IC50=477nM), optimization of various groups led to the synthesis of a potent mGluR5 NAM (32, IC50=75nM) with excellent rat PK profile and good brain penetration. This compound produced oral antidepressant-like effect in a mouse tale suspension model (MED: 30mg/kg). PMID:27432763

  16. Meetings of the American Indian Policy Review Commission (January 6, 7, February 4 and 5, 1977). Volume 5.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Select Committee on Indian Affairs.

    The meetings of the American Indian Policy Review Commission on January 6, 1977, were concerned with the markup of the first draft of the final report, the status of the Commission extension, training, distribution of task force reports, and transition coordination. The session on February 4 opened with the announcement that the Senate had passed…

  17. Thermal expansion, thermal conductivity, and heat capacity measurements for boreholes UE25 NRG-4, UE25 NRG-5, USW NRG-6, and USW NRG-7/7A

    SciTech Connect

    Brodsky, N.S.; Riggins, M.; Connolly, J.; Ricci, P.

    1997-09-01

    Specimens were tested from four thermal-mechanical units, namely Tiva Canyon (TCw), Paintbrush Tuff (PTn), and two Topopah Spring units (TSw1 and TSw2), and from two lithologies, i.e., welded devitrified (TCw, TSw1, TSw2) and nonwelded vitric tuff (PTn). Thermal conductivities in W(mk){sup {minus}1} averaged over all boreholes, ranged (depending upon temperature and saturation state) from 1.2 to 1.9 for TCw, from 0.4 to 0.9 for PTn, from 1.0 to 1.7 for TSw1, and from 1.5 to 2.3 for TSw2. Mean coefficients of thermal expansion were highly temperature dependent and values, averaged over all boreholes, ranged (depending upon temperature and saturation state) from 6.6 {times} 10{sup {minus}6} to 49 {times} 10{sup {minus}6} C{sup {minus}1} for TCw, from the negative range to 16 {times} 10{sup {minus}6} {center_dot} {degree}C{sup {minus}1} for PTn, from 6.3 {times} 10{sup {minus}6} to 44 {times} 10{sup {minus}6} C{sup {minus}1} for TSw1, and from 6.7 {times} 10{sup {minus}6} to 37 {times} 10{sup {minus}6} {center_dot} {degree}C{sup {minus}1} for TSw2. Mean values of thermal capacitance in J/cm{sup 3}K (averaged overall specimens) ranged from 1.6 J to 2.1 for TSw1 and from 1.8 to 2.5 for TSw2. In general, the lithostratigraphic classifications of rock assigned by the USGS are consistent with the mineralogical data presented in this report.

  18. Phagraphene: A Low-Energy Graphene Allotrope Composed of 5-6-7 Carbon Rings with Distorted Dirac Cones.

    PubMed

    Wang, Zhenhai; Zhou, Xiang-Feng; Zhang, Xiaoming; Zhu, Qiang; Dong, Huafeng; Zhao, Mingwen; Oganov, Artem R

    2015-09-01

    Using systematic evolutionary structure searching we propose a new carbon allotrope, phagraphene [fæ'græfi:n], standing for penta-hexa-hepta-graphene, because the structure is composed of 5-6-7 carbon rings. This two-dimensional (2D) carbon structure is lower in energy than most of the predicted 2D carbon allotropes due to its sp(2)-binding features and density of atomic packing comparable to graphene. More interestingly, the electronic structure of phagraphene has distorted Dirac cones. The direction-dependent cones are further proved to be robust against external strain with tunable Fermi velocities. PMID:26262429

  19. Comparison of energy calibration of Prognoz 5, 6, 7, and 8 and other hard-X-ray solar photometers

    NASA Astrophysics Data System (ADS)

    Farnik, F.; Valnicek, B.; Sylwester, B.; Sylwester, J.; Jakimiec, J.

    1984-08-01

    The data obtained by the Prognoz 5, 6, 7, and 8 hard-X-ray photometers are compared with the measurements carried out by similar instruments aboard Solrad 11, ISEE 3, SMM, and Hinotori satellites. Using the method of relative-amplitude analysis, the apparent disagreement in the energy-discrimination-level calibration between the instruments is pointed out. The results of the comparison and possible sources of disagreement are given. An international effort to develop a system of uniform prelaunch calibration of photometers based on a reference calibration source is suggested.

  20. The effects of 7.5% NaCl/6% dextran 70 on coagulation and platelet aggregation in humans

    NASA Technical Reports Server (NTRS)

    Hess, J. R.; Dubick, M. A.; Summary, J. J.; Bangal, N. R.; Wade, C. E.

    1992-01-01

    The combination solution of 7.5% NaCl/6% dextran 70 (HSD) administered IV gives hemodynamic improvement in the treatment of hemorrhagic hypotension. Since earlier dextran solutions were reported to interfere with blood coagulation, the effects of HSD on the prothrombin time (PT), the activated partial thromboplastin time (APTT), platelet aggregation, and platelet concentration were studied. The HSD mixed with human plasma (1:5 and 1:10) slightly prolonged PT, but had no effect on the APTT, compared with saline controls. The HSD also decreased human platelet aggregation at the 1:5 dilution. In separate mixing studies, the hypertonic saline component of HSD was associated with the prolongation of PT and decreased platelet aggregation. The data from these studies indicate that at its proposed therapeutic dose, HSD is expected to have minimal effect on blood coagulation.

  1. Evolution of the observed Lyα luminosity function from z = 6.5 to z = 7.7: evidence for the epoch of reionization?

    NASA Astrophysics Data System (ADS)

    Clément, B.; Cuby, J.-G.; Courbin, F.; Fontana, A.; Freudling, W.; Fynbo, J.; Gallego, J.; Hibon, P.; Kneib, J.-P.; Le Fèvre, O.; Lidman, C.; McMahon, R.; Milvang-Jensen, B.; Moller, P.; Moorwood, A.; Nilsson, K. K.; Pentericci, L.; Venemans, B.; Villar, V.; Willis, J.

    2012-02-01

    Aims: Lyα emitters (LAEs) can be detected out to very high redshifts during the epoch of reionization. The evolution of the LAE luminosity function with redshift is a direct probe of the Lyα transmission of the intergalactic medium (IGM), and therefore of the IGM neutral-hydrogen fraction. Measuring the Lyα luminosity function (LF) of Lyα emitters at redshift z = 7.7 therefore allows us to constrain the ionizing state of the Universe at this redshift. Methods: We observed three 7'.5 × 7'.5 fields with the HAWK-I instrument at the VLT with a narrow band filter centred at 1.06 μm and targeting Lyα emitters at redshift z ~ 7.7. The fields were chosen for the availability of multiwavelength data. One field is a galaxy cluster, the Bullet Cluster, which allowed us to use gravitational amplification to probe luminosities that are fainter than in the field. The two other fields are subareas of the GOODS Chandra Deep Field South and CFHTLS-D4 deep field. We selected z = 7.7 LAE candidates from a variety of colour criteria, in particular from the absence of detection in the optical bands. Results: We do not find any LAE candidates at z = 7.7 in ~2.4 × 104 Mpc3 down to a narrow band AB magnitude of ~26, which allows us to infer robust constraints on the Lyα LAE luminosity function at this redshift. Conclusions: The predicted mean number of objects at z = 6.5, derived from somewhat different luminosity functions of Hu et al. (2010, ApJ, 725, 394), Ouchi et al. (2010, ApJ, 723, 869), and Kashikawa et al. (2011, ApJ, 734, 119) are 2.5, 13.7, and 11.6, respectively. Depending on which of these luminosity functions we refer to, we exclude a scenario with no evolution from z = 6.5 to z = 7.7 at 85% confidence without requiring a strong change in the IGM Lyα transmission, or at 99% confidence with a significant quenching of the IGM Lyα transmission, possibly from a strong increase in the high neutral-hydrogen fraction between these two redshifts. Based on observations

  2. Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase

    PubMed Central

    Lanyon-Hogg, Thomas; Masumoto, Naoko; Bodakh, George; Konitsiotis, Antonio D.; Thinon, Emmanuelle; Rodgers, Ursula R.; Owens, Raymond J.; Magee, Anthony I.; Tate, Edward W.

    2016-01-01

    In this data article we describe synthetic and characterisation data for four members of the 5-acyl-6,7-dihydrothieno[3,2-c]pyridine (termed “RU-SKI”) class of inhibitors of Hedgehog acyltransferase, including associated NMR spectra for final compounds. RU-SKI compounds were selected for synthesis based on their published high potencies against the enzyme target. RU-SKI 41 (9a), RU-SKI 43 (9b), RU-SKI 101 (9c), and RU-SKI 201 (9d) were profiled for activity in the related article “Click chemistry armed enzyme linked immunosorbent assay to measure palmitoylation by Hedgehog acyltransferase” (Lanyon-Hogg et al., 2015) [1]. 1H NMR spectral data indicate different amide conformational ratios between the RU-SKI inhibitors, as has been observed in other 5-acyl-6,7-dihydrothieno[3,2-c]pyridines. The synthetic and characterisation data supplied in the current article provide validated access to the class of RU-SKI inhibitors. PMID:27077078

  3. Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase.

    PubMed

    Lanyon-Hogg, Thomas; Masumoto, Naoko; Bodakh, George; Konitsiotis, Antonio D; Thinon, Emmanuelle; Rodgers, Ursula R; Owens, Raymond J; Magee, Anthony I; Tate, Edward W

    2016-06-01

    In this data article we describe synthetic and characterisation data for four members of the 5-acyl-6,7-dihydrothieno[3,2-c]pyridine (termed "RU-SKI") class of inhibitors of Hedgehog acyltransferase, including associated NMR spectra for final compounds. RU-SKI compounds were selected for synthesis based on their published high potencies against the enzyme target. RU-SKI 41 (9a), RU-SKI 43 (9b), RU-SKI 101 (9c), and RU-SKI 201 (9d) were profiled for activity in the related article "Click chemistry armed enzyme linked immunosorbent assay to measure palmitoylation by Hedgehog acyltransferase" (Lanyon-Hogg et al., 2015) [1]. (1)H NMR spectral data indicate different amide conformational ratios between the RU-SKI inhibitors, as has been observed in other 5-acyl-6,7-dihydrothieno[3,2-c]pyridines. The synthetic and characterisation data supplied in the current article provide validated access to the class of RU-SKI inhibitors. PMID:27077078

  4. Bond Strength of 5th, 6th and 7th Generation Bonding Agents to Intracanal Dentin of Primary Teeth

    PubMed Central

    Afshar, Hossein; Baradaran Nakhjavani, Yahya; Rahro Taban, Sedighe; Baniameri, Zahra; Nahvi, Azam

    2015-01-01

    Objectives: This in-vitro study sought to assess the push-out bond strength of a total etch and 2 self-etch bonding systems to intracanal dentin of primary anterior teeth (PAT). Materials and Methods: Thirty-six primary anterior teeth were randomly divided into 3 groups of 5th generation (Single Bond 2), 6th generation (Clearfil SE) and 7th generation (Single Bond Universal) bonding agents. The canal orifice was restored with composite resin and the push-out test was carried out to assess the bond strength. After applying the push-out load, specimens were evaluated under a light microscope at 40X magnification. One-way ANOVA and log-rank test on Kaplan-Meier curves were applied for the comparison of bond strength among the 3 groups. Results: The mean± standard deviation (SD) bond strength was 13.6±5.33 MPa for Single Bond 2, 13.85±5.86 MPa for Clearfil SE and 12.28±5.24 MPa for Single Bond Universal. The differences in bond strength among the 3 groups were not statistically significant (P>0.05). Conclusion: All three bonding agents are recommended for use with composite posts in PAT. However, due to high technical sensitivity of the Total Etch system, single or two-step self etch systems may be preferred for uncooperative children. PMID:26056518

  5. Photophysical properties of ESIPT inspired fluorescent 2-(2-hydroxyphenyl)-6-methylimidazo[4,5-f]isoindole-5,7(1H,6H)-dione and its derivative: Experimental and DFT based approach

    NASA Astrophysics Data System (ADS)

    Deshmukh, Mininath S.; Sekar, Nagaiyan

    2015-01-01

    The excited-state intramolecular proton transfer chromophores 2-(2-hydroxyphenyl)-6-methylimidazo[4,5-f]isoindole-5,7(1H,6H)-dione and 2-(4-(diethylamino)-2-hydroxyphenyl)-6-methylimidazo[4,5-f]isoindole-5,7(1H,6H)-dione are synthesized from 4,5-diamino-N-methylphthalimide. The photophysical behavior of the synthesized chromophores was studied using UV-visible and fluorescence spectroscopy in the polar and non-polar solvents. The synthesized o-hydroxyphenyl benzimidazole derivatives are fluorescent and very sensitive to the solvent polarity. These dyes are thermally stable up to 317 °C. Density Functional Theory computations have been used to understand the structural, molecular, electronic and photophysical properties of the chromophores. The experimental absorption and emission wavelengths are in good agreement with the computed vertical excitation and theoretical emission obtained by Density Functional Theory and Time Dependant Density Functional Theory.

  6. Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4, 5a, 6a, 7a and 7b.

    PubMed

    Fornuskova, Daniela; Stiburek, Lukas; Wenchich, Laszlo; Vinsova, Kamila; Hansikova, Hana; Zeman, Jiri

    2010-06-15

    Mammalian CcO (cytochrome c oxidase) is a hetero-oligomeric protein complex composed of 13 structural subunits encoded by both the mitochondrial and nuclear genomes. To study the role of nuclear-encoded CcO subunits in the assembly and function of the human complex, we used stable RNA interference of COX4, COX5A and COX6A1, as well as expression of epitope-tagged Cox6a, Cox7a and Cox7b, in HEK (human embryonic kidney)-293 cells. Knockdown of Cox4, Cox5a and Cox6a resulted in reduced CcO activity, diminished affinity of the residual enzyme for oxygen, decreased holoCcO and CcO dimer levels, increased accumulation of CcO subcomplexes and gave rise to an altered pattern of respiratory supercomplexes. An analysis of the patterns of CcO subcomplexes found in both knockdown and overexpressing cells identified a novel CcO assembly intermediate, identified the entry points of three late-assembled subunits and demonstrated directly the essential character as well as the interdependence of the assembly of Cox4 and Cox5a. The ectopic expression of the heart/muscle-specific isoform of the Cox6 subunit (COX6A2) resulted in restoration of both CcO holoenzyme and activity in COX6A1-knockdown cells. This was in sharp contrast with the unaltered levels of COX6A2 mRNA in these cells, suggesting the existence of a fixed expression programme. The normal amount and function of respiratory complex I in all of our CcO-deficient knockdown cell lines suggest that, unlike non-human CcO-deficient models, even relatively small amounts of CcO can maintain the normal biogenesis of this respiratory complex in cultured human cells. PMID:20307258

  7. Protective effects of (6R)-5,6,7,8-tetrahydro-l-biopterin on local ischemia/reperfusion-induced suppression of reactive hyperemia in rat gingiva

    PubMed Central

    Tanaka, Yusaku; Toyama, Toshizo; Wada-Takahashi, Satoko; Sasaki, Haruka; Miyamoto, Chihiro; Maehata, Yojiro; Yoshino, Fumihiko; Yoshida, Ayaka; Takahashi, Shun-suke; Watanabe, Kiyoko; Lee, Masaichi-Chang-il; Todoki, Kazuo; Hamada, Nobushiro

    2016-01-01

    We herein investigated the regulatory mechanism in the circulation responsible for rat gingival reactive hyperemia (RH) associated with ischemia/reperfusion (I/R). RH was analyzed using a laser Doppler flowmeter. RH and I/R were elicited by gingival compression and release with a laser Doppler probe. RH increased in a time-dependent manner when the duration of compression was between 30 s and 20 min. This increase was significantly suppressed by Nω-nitro-l-arginine-methyl-ester (l-NAME), 7-nitroindazole (7-NI), and 2,4-diamino-6-hydroxypyrimidine (DAHP). However, RH was markedly inhibited following 60 min of compression. This inhibition was significantly decreased by treatments with superoxide dismutase (SOD), (6R)-5,6,7,8-tetrahydro-l-biopterin (BH4), and sepiapterin. The luminescent intensity of superoxide anion (O2•−)-induced 2-methyl-6-(4-methoxyphenyl)-3,7-dihydroimidazo-[1,2-a] pyrazine-3-one (MCLA) was markedly decreased by SOD and BH4, but only slightly by sepiapterin. BH4 significantly decreased O2•− scavenging activity in a time-dependent manner. These results suggested that nitric oxide (NO) secreted by the nitrergic nerve played a role in regulating local circulation in rat gingiva. This NO-related regulation of local circulation was temporarily inhibited in the gingiva by the I/R treatment. The decrease observed in the production of NO, which was caused by suppression of NO synthase (NOS) activity subsequent to depletion of the NOS co-factor BH4 by O2•−, played a partial role in this inhibition. PMID:26798200

  8. Synthesis and anticancer activities of 4-(4-substituted piperazin)-5,6,7-trialkoxy quinazoline derivatives.

    PubMed

    Zhang, Ying; Huang, Yin-Jiu; Xiang, Hong-Mei; Wang, Pei-Yi; Hu, De-Yu; Xue, Wei; Song, Bao-An; Yang, Song

    2014-05-01

    A series of 4-(4-substituted piperazin)-5,6,7-trialkoxy quinazoline was prepared by conventional heating methods. Among these compounds, the crystal structure of compound 10o (CCDC: 916922) was determined by X-ray crystallography. Bioassay results showed that most target compounds had certain inhibition activities against proliferation of tumor cells, and some compounds even had good broad-spectrum inhibition activities. The ethoxyl series of compounds possessed higher inhibition activities against tumor cells than the methoxyl series of compounds. Bioactivity tests showed that the IC50 values of compound 10s against PC3, MGC803, A375, and A549 cells were 1.8, 2.8, 1.3, and 2.9 μΜ, respectively, which were much higher than those of commercial gefitinib (7.2, 7.6, 7.2, and 9.8 μM, respectively). Conversely, the IC50 values of compound 10s were very low against NH3T3, indicating only weak effect on normal cells as also proven by lactate dehydrogenase and acridine orange/ethidium bromide staining. Analyses of cell configuration and cell cycle revealed that compound 10s possibly caused cells to remain at G0/G1 phase by inhibiting cell proliferation for 24 h. Compound 10s also inhibited the phosphorylation of ERK1/2 and P38 with obvious concentration dependence. Thus, these compounds can inhibit the proliferation of A549 cells through the interruption of ERK1/2 and P38signaling pathways. PMID:24675177

  9. 40 CFR 721.5262 - 2,7-Naphthalenedisulfonic acid, 5-[[4-chloro-6-[substituted] amino]-1,3,5-triazin-2-yl]amino]-4...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...,7-Naphthalenedisulfonic acid, 5- amino]-1,3,5-triazin-2-yl]amino]-4-hydroxy-3- -, trisodium salt... identified generically as 2,7-Naphthalenedisulfonic acid, 5- amino]-1,3,5-triazin-2-yl]amino]-4-hydroxy-3... 40 Protection of Environment 32 2012-07-01 2012-07-01 false 2,7-Naphthalenedisulfonic acid,...

  10. 40 CFR 721.5262 - 2,7-Naphthalenedisulfonic acid, 5-[[4-chloro-6-[substituted] amino]-1,3,5-triazin-2-yl]amino]-4...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...,7-Naphthalenedisulfonic acid, 5- amino]-1,3,5-triazin-2-yl]amino]-4-hydroxy-3- -, trisodium salt... identified generically as 2,7-Naphthalenedisulfonic acid, 5- amino]-1,3,5-triazin-2-yl]amino]-4-hydroxy-3... 40 Protection of Environment 32 2013-07-01 2013-07-01 false 2,7-Naphthalenedisulfonic acid,...

  11. Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824

    PubMed Central

    Li, Xiaojin; Manjunatha, Ujjini H.; Goodwin, Michael B.; Knox, John E.; Lipinski, Christopher A.; Keller, Thomas H.; Barry, Clifton E.; Dowd, Cynthia S.

    2008-01-01

    Nitroimidazoles such as PA-824 and OPC-67683 are currently in clinical development as members of a promising new class of therapeutics for tuberculosis. While the antitubercular activity of these compounds is high, they both suffer from poor water solubility thus complicating development. We determined the single-crystal X-ray structure of PA-824 and found a close packing of the nitroimidazoles facilitated by a pseudoaxial conformation of the p-trifluoromethoxybenzyl ether. To attempt to disrupt this tight packing by destabilizing the axial preference of this side chain, we prepared the two diastereomers of the 7-methyl-nitroimidazo-oxazine. Determination of the crystal structure of the 7-(S)-methyl derivative (5, cis) revealed that the benzylic side chain remained pseudoaxial while the 7-(R)-methyl derivative (6, trans) adopted the desired pseudoequatorial conformation. Both derivatives displayed similar activities against Mycobacterium tuberculosis, but neither showed improved aqueous solubility, suggesting that inherent lattice stability is not likely to be a major factor in limiting solubility. Conformational analysis revealed that all three compounds have similar energetically accessible conformations in solution. Additionally, these results suggest that the nitroreductase that initially recognizes PA-824 is somewhat insensitive to substitutions at the 7-position. PMID:18358721

  12. Design, synthesis and evaluation of novel 5,6,7-trimethoxyflavone-6-chlorotacrine hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.

    PubMed

    Liao, Shixian; Deng, Hui; Huang, Shengbin; Yang, Jingyuan; Wang, Siqian; Yin, Baodi; Zheng, Tieli; Zhang, Dafeng; Liu, Jinsong; Gao, Guohui; Ma, Jianfeng; Deng, Zhennan

    2015-04-01

    A series of 5,6,7-trimethoxyflavone-6-chlorotacrine hybrids were designed, synthesized and evaluated as multifunctional agents for the treatment of Alzheimer's disease (AD). The results showed that the target compounds exhibited good acetylcholinesterase (AChE) inhibitory potencies, high selectivity toward AChE over butyrylcholinesterase (BuChE), potential antioxidant activities and significant inhibitory potencies of self-induced beta-amyloid peptide (Aβ) aggregation. In particular, compound 14c had the strongest AChE inhibitory activity with IC50 value of 12.8 nM, potent inhibition of self-induced Aβ1-42 aggregation with inhibition ratio of 33.8% at 25 μM. Moreover, compound 14c acted as an antioxidant, as well as a neuroprotectant. Furthermore, 14c could cross the blood-brain barrier (BBB) in vitro. The results showed that compound 14c might be a potential multifunctional candidate for the treatment of AD. PMID:25724825

  13. SAMS Acceleration Measurements on Mir from May 1997 to June 1998 (NASA Increments 5, 6, and 7)

    NASA Technical Reports Server (NTRS)

    DeLombard, Richard

    1999-01-01

    During NASA Increments 5, 6, and 7 (May 1997 to June 1998), about eight gigabytes of acceleration data were collected by the Space Acceleration Measurement System (SAMS) onboard the Russian Space Station Mir. The data were recorded on twenty-seven optical disks which were returned to Earth on Orbiter missions STS-86, STS-89, and STS-91. During these increments, SAMS data were collected in the Priroda module to support various microgravity experiments. This report points out some of the salient features of the microgravity acceleration environment to which the experiments were exposed. This report presents an overview of the SAMS acceleration measurements recorded by 10 Hz and 100 Hz sensor heads. The analyses included herein complement those presented in previous Mir increment summary reports prepared by the Principal Investigator Microgravity Services project.

  14. Molecular and crystal structures of some novel derivatives of 3-aryl-7-arylidene-3,3a,4,5,6,7-hexahydroindazoles

    SciTech Connect

    Abakumov, V. V.; Shishkina, S. V.; Zubatyuk, R. I.; Gella, I. M.; Pivnenko, N. S.; Kutulya, L. A. Shishkin, O. V.

    2007-03-15

    The stereochemical aspects of the interaction of 2,6-bis(arylidene)-cyclohexanone and 2,6-bis(arylidene)-3-methylcyclohexanone with arylhydrazine (aryl is phenyl or 4-nitrophenyl) and methylhydrazine are investigated using X-ray diffraction analysis. The molecular structure of the 3-aryl-7-arylidene-3,3a,4,5,6,7-hexahydroindazoles synthesized is determined by X-ray diffraction analysis for the first time. It is established that the stereochemistry of the products of the interaction between the cyclohexanone derivatives and arylhydrazines depends on the electronic nature of the substituent in the aryl group. Two regioisomeric products with different positions of the methyl group in the cyclohexane ring with respect to the arylidene fragment are synthesized by the reaction of 2,6-bis(4-methoxybenzylidene)-3-methylcyclohexanone with methylhydrazine. The influence of the substituents at the nitrogen atom of the pyrazoline ring on the intramolecular electronic interactions and the geometry of the heterocycle in the compounds under investigation is discussed.

  15. Praxis release notes, Versions 7. 6 and 7. 7

    SciTech Connect

    Holloway, F.W.

    1986-03-13

    Improvements in the Praxis compiler are discussed. Improvements in Version 7.6 include: (1) range checking; (2) traceback on uncaught exceptions; (3) better diagnostics; (4) more run time library support; and (5) error messages to files. Improvements in Version 7.7 include: (1) linking of shareable images; (2) an extensive suite of test/example programs; (3) round, ceiling and floor functions; (4) structure definitions; (5) conversion of real to/from 32 bit integer on PDP; (6) return of a flexible array from a function; and (7) high of variadic parameters. (WRF)

  16. Synthesis and characterization of p-type conductivity dopant 2-(3-(adamantan-1-yl)propyl)-3,5,6-trifluoro-7,7,8,8-tetracyanoquinodimethane

    SciTech Connect

    Rainbolt, James E.; Koech, Phillip K.; Polikarpov, Evgueni; Swensen, James S.; Cosimbescu, Lelia; Von Ruden, Amber L.; Wang, Liang; Sapochak, Linda S.; Padmaperuma, Asanga B.; Gaspar, Daniel J.

    2013-01-22

    We report the synthesis and characterization of 2-(3-(adamantan-1-yl)propyl)-3,5,6-trifluoro-7,7,8,8-tetracyanoquinodimethane (F3TCNQ-Ad1), a substituted analog of 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane (F4TCNQ), designed for p-type conductivity doping. The dopant is designed as a model for substituted alternatives to F4TCNQ that maintain similar electronic properties with the goal of engineering dopants with superior fabrication characteristics over F4TCNQ. We describe the design strategy for F3TCNQ-Ad1 based on molecular modeling predictions that substitution of a single fluorine atom of F4TCNQ has little effect on the electronic properties of the molecule. Photophysical and electrochemical characterization reveal that the adamantyl substituent in F3TCNQ-Ad1 does not significantly alter the electronic properties of the substituted dopant relative to F4TCNQ. Unfortunately, F3TCNQ-Ad1 degrades under standard sublimation conditions, preventing sublimation deposition processing. Instead, hole-only devices were made via solution-processing of the p-doped films with the structure glass/ITO/2.3 x103Å PVK:(MTDATA:dopant)/2.0x102Å Au/1.0x103Å Al, where dopant is either F4TCNQ or F3TCNQ-Ad1. We demonstrate that F3TCNQ-Ad1 increased the conductivity of the films by at least 1,000 times compared to an undoped device.

  17. MELCOR 1.8.2 assessment: Aerosol experiments ABCOVE AB5, AB6, AB7, and LACE LA2

    SciTech Connect

    Souto, F.J.; Haskin, F.E.; Kmetyk, L.N.

    1994-10-01

    The MELCOR computer code has been used to model four of the large-scale aerosol behavior experiments conducted in the Containment System Test Facility (CSTF) vessel. Tests AB5, AB6 and AB7 of the ABCOVE program simulate the dry aerosol conditions during a hypothetical severe accident in an LMFBR. Test LA2 of the LACE program simulates aerosol behavior in a condensing steam environment during a postulated severe accident in an LWR with failure to isolate the containment. The comparison of code results to experimental data show that MELCOR is able to correctly predict most of the thermal-hydraulic results in the four tests. MELCOR predicts reasonably well the dry aerosol behavior of the ABCOVE tests, but significant disagreements are found in the aerosol behavior modelling for the LA2 experiment. These results tend to support some of the concerns about the MELCOR modelling of steam condensation onto aerosols expressed in previous works. During these analyses, a limitation in the MELCOR input was detected for the specification of the aerosol parameters for more than one component. A Latin Hypercube Sampling (LHS) sensitivity study of the aerosol dynamic constants is presented for test AB6. The study shows the importance of the aerosol shape factors in the aerosol deposition behavior, and reveals that MELCOR input/output processing is highly labor intensive for uncertainty and sensitivity analyses based on LHS.

  18. 40 CFR 721.5262 - 2,7-Naphthalenedisulfonic acid, 5-[[4-chloro-6-[substituted] amino]-1,3,5-triazin-2-yl]amino]-4...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...- amino]-1,3,5-triazin-2-yl]amino]-4-hydroxy-3- -, trisodium salt (generic). 721.5262 Section 721.5262...,7-Naphthalenedisulfonic acid, 5- amino]-1,3,5-triazin-2-yl]amino]-4-hydroxy-3- -, trisodium salt... identified generically as 2,7-Naphthalenedisulfonic acid, 5-......

  19. 40 CFR 721.5262 - 2,7-Naphthalenedisulfonic acid, 5-[[4-chloro-6-[substituted] amino]-1,3,5-triazin-2-yl]amino]-4...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...- amino]-1,3,5-triazin-2-yl]amino]-4-hydroxy-3- -, trisodium salt (generic). 721.5262 Section 721.5262...,7-Naphthalenedisulfonic acid, 5- amino]-1,3,5-triazin-2-yl]amino]-4-hydroxy-3- -, trisodium salt... identified generically as 2,7-Naphthalenedisulfonic acid, 5-......

  20. Synthesis and identification of a new class of (S)-2,6-diamino-4,5,6,7-tetrahydrobenzo[d]thiazole derivatives as potent antileukemic agents.

    PubMed

    Prasanna, D S; Kavitha, C V; Raghava, B; Vinaya, K; Ranganatha, S R; Raghavan, Sathees C; Rangappa, K S

    2010-08-01

    Benzothiazoles are multitarget agents with broad spectrum of biological activity. Among the antitumor agents discovered in recent years, the identification of various 2-(4-aminophenyl) benzothiazoles as potent and selective antitumor drugs against different cancer cell lines has stimulated remarkable interest. Some of the benzothiazoles are known to induce cell cycle arrest, activation of caspases and interaction with DNA molecule. Based on these interesting properties of benzothiazoles and to obtain new biologically active agents, a series of novel 4,5,6,7-tetrahydrobenzo[d]thiazole derivatives 5(a-i) were synthesized and evaluated for their efficacy as antileukemic agents in human leukemia cells (K562 and Reh). The chemical structures of the synthesized compounds were confirmed by (1)H NMR, LCMS and IR analysis. The cytotoxicity of these compounds were determined using trypan blue exclusion, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and lactate dehydrogenase (LDH) assays. Results showed that, these compounds mediate a significant cytotoxic response to cancer cell lines tested. We found that the compounds having electron withdrawing groups at different positions of the phenyl ring of the thiourea moiety displayed significant cytotoxic effect with IC(50) value less than 60 microM. To rationalize the role of electron withdrawing group in the induction of cytotoxicity, we have chosen molecule 5g (IC(50) approximately 15 microM) which is having chloro substitution at ortho and para positions. Flow cytometric analysis of annexin V-FITC/ propidium iodide (PI) double staining and DNA fragmentation suggest that 5g can induce apoptosis. PMID:19506804

  1. Development of a high-resolution record of Great Basin climate change during MIS 5, 6, and 7

    NASA Astrophysics Data System (ADS)

    Cross, M.; McGee, D.; Broecker, W. S.; Quade, J.; Cheng, H.; Edwards, R.

    2013-12-01

    As evinced by the cycles of the large paleolakes Lahontan and Bonneville, the currently semi-arid to arid Great Basin region of the United States has experienced significant changes in climate and water balance in the past. Although there has been substantial research concerning these changes for times around and since the last glacial maximum, relatively little is known about the region's previous climate and water balance history. There is a clear need for a long-term record for earlier glacial and interglacial periods. Here, we present some of our initial results from Lehman Cave (39.01°N, 114.22°W), a well-decorated, active cave located on the edge of the Bonneville Basin in the Great Basin National Park, for times correlating with large portions of Marine Oxygen Isotope Stages (MIS) 5, 6, and 7. We initially surveyed a suite of speleothems to obtain times and durations of growth phases to aid in choosing samples appropriate for more extensive analysis. Approximately eighty 2 to 10 mg samples with a mean 238U of 400 ppb, representing most of the major growth phases of this suite of 20 speleothems, were analyzed for preliminary uranium-thorium dates. A subset of eight of these stalagmites grew collectively over large portions of MIS 5 and 6 (an interval that includes the Little Valley lake cycle of the Bonneville Basin) as well as a substantial portion of MIS 7. This record includes several significant periods of contemporaneous growth, including: 81.5 to 103 ka, which corresponds to the interval between Dansgaard-Oeschger events 21 and 23; 204 to 207 ka; and 118 to 132 ka, an interval including the beginning of the last interglacial period and the end of Termination II and Heinrich Stadial 11. We have yet to identify growth phases between 103 to 118 ka, 134 to 137 ka, and 164 to 169 ka. Initial stable isotope results indicate a shift of approximately +3‰ δ18O and +5‰ δ13C around 131 × 2.5 ka, which agrees within error with the findings of Shakun et al

  2. ADN-1184 a monoaminergic ligand with 5-HT6/7 receptor antagonist activity: pharmacological profile and potential therapeutic utility

    PubMed Central

    Kołaczkowski, M; Mierzejewski, P; Bieńkowski, P; Wesołowska, A; Newman-Tancredi, A

    2014-01-01

    Background and Purpose Many dementia patients exhibit behavioural and psychological symptoms (BPSD) that include psychosis, aggressivity, depression and anxiety. Antipsychotic drugs are frequently prescribed but fail to significantly attenuate mood deficits, may interfere with cognitive function and are associated with motor and cardiac side effects, which are problematic in elderly patients. A need therefore exists for drugs that are better suited for the treatment of BPSD. Experimental Approach We used in vitro cellular and in vivo behavioural tests to characterize ADN-1184, a novel arylsulfonamide ligand with potential utility for treatment of BPSD. Key Results ADN-1184 exhibits substantial 5-HT6/5-HT7/5-HT2A/D2 receptor affinity and antagonist properties in vitro. In tests of antipsychotic-like activity, it reversed MK-801-induced hyperactivity and stereotypies and inhibited conditioned avoidance response (MED = 3 mg·kg−1 i.p.). Remarkably, ADN-1184 also reduced immobility time in the forced swim test at low doses (0.3 and 1 mg·kg−1 i.p.; higher doses were not significantly active). Notably, up to 30 mg·kg−1 ADN-1184 did not impair memory performance in the passive avoidance test or elicit significant catalepsy and only modestly inhibited spontaneous locomotor activity (MED = 30 mg·kg−1 i.p.). Conclusions and Implications ADN-1184 combines antipsychotic-like with antidepressant-like properties without interfering with memory function or locomotion. This profile is better than that of commonly used atypical antipsychotics tested under the same conditions and suggests that it is feasible to identify drugs that improve BPSD, without exacerbating cognitive deficit or movement impairment, which are of particular concern in patients with dementia. PMID:24199650

  3. In Situ TEM Observations of Cu6Sn5 Polymorphic Transformations in Reaction Layers Between Sn-0.7Cu Solders and Cu Substrates

    NASA Astrophysics Data System (ADS)

    Nogita, K.; Mohd Salleh, M. A. A.; Tanaka, E.; Zeng, G.; McDonald, S. D.; Matsumura, S.

    2016-07-01

    Direct evidence of the relationship between the polymorphic phase transformation from monoclinic Cu6Sn5 to hexagonal Cu6Sn5 and stress accumulation/release in Cu6Sn5, formed at the interface between Sn-0.7Cu lead-free solder and their Cu substrates, has been obtained. To explore this challenging phenomenon, we developed an in situ heating/isothermal observation technique in ultrahigh-voltage transmission electron microscopy that enables the observation of thick samples (around 0.5 μm) for solder joints, including Cu/Cu3Sn/Cu6Sn5/Sn-0.7Cu solder interfaces prepared by a focused ion beam milling technique. The results show evidence of stress creation and release events by imaging bend contours that may arise due to the polymorphic transformations of the Cu6Sn5 phase and the associated volumetric change.

  4. Effects of 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane doping on diketopyrrolopyrrole-based, low crystalline, high mobility polymeric semiconductor

    SciTech Connect

    Yoon, Seongwon; Cho, Jangwhan; Chung, Dae Sung; Lee, Han-Koo; Park, Sungmin; Son, Hae Jung

    2015-09-28

    The effects of 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane (F4TCNQ) doping on diketopyrrolo-pyrrole-based polymeric semiconductors in terms of charge transport behavior and structural ordering are systematically investigated. Although the energy level offset between the polymeric semiconductor and the F4TCNQ acceptor was not particularly large, ultraviolet photoelectron spectroscopy analyses revealed that a low doping ratio of 1 wt. % is sufficient to tune the energy distance between the Fermi level and the HOMO level, reaching saturation at roughly 5 wt. %, which is further confirmed by the depletion mode measurements of field effect transistors (FETs). Structural analyses using grazing-incidence X-ray diffraction (GIXD) show that the overall degree of edge-on orientation is disturbed by the addition of dopants, with significant influence appearing at high doping ratios (>3 wt. %). The calculated charge carrier mobility from accumulation mode measurements of FETs showed a maximum value of 2 cm{sup 2}/V·s at the optimized doping ratio of 1%, enabled by additional holes in the channel region, which results in a roughly 40% increase relative to the undoped device. Further increases in the doping ratio, however, resulted in worse FET performance, which can be attributed to structural deformation. This result suggests that the electrochemical doping method can be also applied to donor-acceptor copolymers to further enhance their charge transport characteristics, once the optimized doping condition has been established.

  5. Photophysical properties of ESIPT inspired fluorescent 2-(2-hydroxyphenyl)-6-methylimidazo[4,5-f]isoindole-5,7(1H,6H)-dione and its derivative: experimental and DFT based approach.

    PubMed

    Deshmukh, Mininath S; Sekar, Nagaiyan

    2015-01-25

    The excited-state intramolecular proton transfer chromophores 2-(2-hydroxyphenyl)-6-methylimidazo[4,5-f]isoindole-5,7(1H,6H)-dione and 2-(4-(diethylamino)-2-hydroxyphenyl)-6-methylimidazo[4,5-f]isoindole-5,7(1H,6H)-dione are synthesized from 4,5-diamino-N-methylphthalimide. The photophysical behavior of the synthesized chromophores was studied using UV-visible and fluorescence spectroscopy in the polar and non-polar solvents. The synthesized o-hydroxyphenyl benzimidazole derivatives are fluorescent and very sensitive to the solvent polarity. These dyes are thermally stable up to 317 °C. Density Functional Theory computations have been used to understand the structural, molecular, electronic and photophysical properties of the chromophores. The experimental absorption and emission wavelengths are in good agreement with the computed vertical excitation and theoretical emission obtained by Density Functional Theory and Time Dependant Density Functional Theory. PMID:25108369

  6. 5-Demethylnobiletin and 5-Acetoxy-6,7,8,3',4'-pentamethoxyflavone Suppress Lipid Accumulation by Activating the LKB1-AMPK Pathway in 3T3-L1 Preadipocytes and High Fat Diet-Fed C57BL/6 Mice.

    PubMed

    Tung, Yen-Chen; Li, Shiming; Huang, Qingrong; Hung, Wei-Lun; Ho, Chi-Tang; Wei, Guor-Jien; Pan, Min-Hsiung

    2016-04-27

    Polymethoxyflavones (PMFs) and hydroxylated polymethoxyflavones (HPMFs), such as nobiletin (Nob) and 5-demethylnobiletin (5-OH-Nob), are unique flavonoids that are found exclusively in citrus peels. Nobiletin has been shown to suppress adipogenesis in vitro, but the antiadipogenic activity of 5-OH-Nob has not been investigated. Both nobiletin and 5-OH-Nob have poor aqueous solubility and low oral bioavailability. We employed chemical modification to produce the acetyl derivative of 5-OH-Nob, that is, 5-acetyloxy-6,7,8,3',4'-pentamethoxyflavone (5-Ac-Nob), to improve its bioavailability and bioactive efficiency. We found that 5-Ac-Nob reduced triacylglycerol (TG) content to a greater extent than 5-OH-Nob in 3T3-L1 preadipocytes. Orally administered 5-Ac-Nob resulted in a significant reduction in body weight, intra-abdominal fat, plasma and liver TG levels, and plasma cholesterol level in high fat diet-induced obese male C57BL/6J mice. The 5-Ac-Nob treatment decreased lipid accumulation by triggering the adenosine 5'-monophosphate-activated protein kinase (AMPK) pathway to alter transcriptional factors or lipogenesis-related enzymes in vivo and in vitro. PMID:27041493

  7. 40 CFR 721.5262 - 2,7-Naphthalenedisulfonic acid, 5-[[4-chloro-6-[substituted] amino]-1,3,5-triazin-2-yl]amino]-4...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...,7-Naphthalenedisulfonic acid, 5- amino]-1,3,5-triazin-2-yl]amino]-4-hydroxy-3- -, trisodium salt...-Naphthalenedisulfonic acid, 5- amino]-1,3,5-triazin-2-yl]amino]-4-hydroxy-3- -, trisodium salt (PMN P-00-0803) is...-naphthalenedisulfonic acid, 5- ethyl]amino]-1,3,5-triazin-2-yl]amino]-4-hydroxy-3- -, sodium salt (1:3) (PMN......

  8. Crystallization Kinetics of Fe76.5- x C6.0Si3.3B5.5P8.7Cu x ( x = 0, 0.5, and 1 at. pct) Bulk Amorphous Alloy

    NASA Astrophysics Data System (ADS)

    Jung, Hyo Yun; Stoica, Mihai; Yi, Seonghoon; Kim, Do Hyang; Eckert, Jürgen

    2015-06-01

    The influence of Cu on crystallization kinetics of Fe76.5- x C6.0Si3.3B5.5P8.7Cu x ( x = 0, 0.5, and 1 at. pct) bulk amorphous alloys was investigated by isothermal and isochronal differential scanning calorimetry combined with X-ray diffraction. The thermal analysis revealed that the crystallization of the amorphous matrix proceeds through at least two exothermic events. The Cu-free glassy alloy forms by primary crystallization the metastable Fe23C6 phase, while upon 0.5 at. pct Cu addition the primary crystallized phase is α-Fe. The activation energy for crystallization, calculated using both Kissinger and Ozawa methods, decreases from about 500 kJ/mol to about 330 kJ/mol. Further increase of Cu addition to 1 at. pct promotes the concomitant crystallization of several phases, as α-Fe, FeB, Fe3C, and Fe2P. In order to understand the crystallization behavior of the alloys as a function of Cu content, the Avrami exponent n, evaluated from the Johnson-Mehl-Avrami equation, was in details analyzed. The current study reveals that the minor Cu addition plays a crucial role at the initial stage of the crystallization. Among the studied alloys, the glassy samples with 0.5 at. pct Cu addition have the optimum compositional condition for the single α-Fe formation with a high nucleation rate.

  9. Ins(1,4,5)P3 interacts with PIP2 to regulate activation of TRPC6/C7 channels by diacylglycerol in native vascular myocytes

    PubMed Central

    Ju, Min; Shi, Jian; Saleh, Sohag N; Albert, Anthony P; Large, William A

    2010-01-01

    We investigated synergism between inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and diacylglycerol (DAG) on TRPC6-like channel activity in rabbit portal vein myocytes using single channel recording and immunoprecipitation techniques. Ins(1,4,5)P3 at 10 μm increased 3-fold TRPC6-like activity induced by 10 μm 1-oleoyl-2-acetyl-sn-glycerol (OAG), a DAG analogue. Ins(1,4,5)P3 had no effect on OAG-induced TRPC6 activity in mesenteric artery myocytes. Anti-TRPC6 and anti-TRPC7 antibodies blocked channel activity in portal vein but only anti-TRPC6 inhibited activity in mesenteric artery. TRPC6 and TRPC7 proteins strongly associated in portal vein but only weakly associated in mesenteric artery tissue lysates. Therefore in portal vein the conductance consists of TRPC6/C7 subunits, while OAG activates a homomeric TRPC6 channel in mesenteric artery myocytes. Wortmannin at 20 μm reduced phosphatidylinositol 4,5-bisphosphate (PIP2) association with TRPC6 and TRPC7, and produced a 40-fold increase in OAG-induced TRPC6/C7 activity. Anti-PIP2 antibodies evoked TRPC6/C7 activity, which was blocked by U73122, a phospholipase C inhibitor. DiC8-PIP2, a water-soluble PIP2 analogue, inhibited OAG-induced TRPC6/C7 activity with an IC50 of 0.74 μm. Ins(1,4,5)P3 rescued OAG-induced TRPC6/C7 activity from inhibition by diC8-PIP2 in portal vein myocytes, and this was not prevented by the Ins(1,4,5)P3 receptor antagonist heparin. In contrast, Ins(1,4,5)P3 did not overcome diC8-PIP2-induced inhibition of TRPC6 activity in mesenteric artery myocytes. 2,3,6-Tri-O-butyryl-Ins(1,4,5)P3/AM (6-Ins(1,4,5)P3), a cell-permeant analogue of Ins(1,4,5)P3, at 10 μm increased TRPC6/C7 activity in portal vein and reduced association between TRPC7 and PIP2, but not TRPC6 and PIP2. In contrast, 10 μm OAG reduced association between TRPC6 and PIP2, but not between TRPC7 and PIP2. The present work provides the first evidence that Ins(1,4,5)P3 modulates native TRPC channel activity through removal of the

  10. Theoretical vibrations of carbon chains C3, C4, C5, C6, C7, C8, and C9

    NASA Technical Reports Server (NTRS)

    Kurtz, Joe; Adamowicz, Ludwik

    1991-01-01

    The MBPT (2) procedure with the 6-31g (asterisk) basis set was used to study nearly linear carbon chains. The theoretical vibrational frequencies of the molecules C3 through C9 are presented and, for C3 through C6, compared to experimental stretching frequencies and their (C-13)/(C-12) isotopomers. Predictions for C7, C8, and C9 stretching frequencies are calculated by directly scaling the theoretical frequencies with factors derived from experimental-to-theoretical ratios known for the smaller molecules.

  11. Studies to investigate the in vivo therapeutic window of the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY411,575) in the CRND8 mouse.

    PubMed

    Hyde, Lynn A; McHugh, Nansie A; Chen, Joseph; Zhang, Qi; Manfra, Denise; Nomeir, Amin A; Josien, Hubert; Bara, Thomas; Clader, John W; Zhang, Lili; Parker, Eric M; Higgins, Guy A

    2006-12-01

    Accumulation of amyloid beta-peptide (Abeta) is considered a key step in the etiology of Alzheimer's disease. Abeta is produced by sequential cleavage of the amyloid precursor protein by beta- and gamma-secretase enzymes. Consequently, inhibition of gamma-secretase provides a promising therapeutic approach to treat Alzheimer's disease. Preclinically, several gamma-secretase inhibitors have been shown to reduce plasma and brain Abeta, although they also produce mechanism-based side effects, including thymus atrophy and intestinal goblet cell hyperplasia. The present studies sought to establish an efficient screen for determining the therapeutic window of gamma-secretase inhibitors and to test various means of maximizing this window. Six-day oral administration of the gamma-secretase inhibitor N(2)-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N(1)-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-l-alaninamide (LY411,575) reduced cortical Abeta(40) in young (preplaque) transgenic CRND8 mice (ED(50) approximately 0.6 mg/kg) and produced significant thymus atrophy and intestinal goblet cell hyperplasia at higher doses (>3 mg/kg). The therapeutic window was similar after oral and subcutaneous administration and in young and aged CRND8 mice. Both the thymus and intestinal side effects were reversible after a 2-week washout period. Three-week treatment with 1 mg/kg LY411,575 reduced cortical Abeta(40) by 69% without inducing intestinal effects, although a previously unreported change in coat color was observed. These studies demonstrate that the 3- to 5-fold therapeutic window for LY411,575 can be exploited to obtain reduction in Abeta levels without induction of intestinal side effects, that intermittent treatment could be used to mitigate side effects, and that a 6-day dosing paradigm can be used to rapidly determine the therapeutic window of novel gamma-secretase inhibitors. PMID:16946102

  12. Molecular doping of regioregular poly(3-hexylthiophene) layers by 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane investigated by infrared spectroscopy and electrical measurements

    NASA Astrophysics Data System (ADS)

    Tadaki, Daisuke; Ma, Teng; Zhang, Jinyu; Iino, Shohei; Hirano-Iwata, Ayumi; Kimura, Yasuo; Niwano, Michio

    2015-09-01

    Molecular doping is a charge-transfer process intended to improve the performance of organic electronic devices such as organic transistors. We have investigated molecular doping of regioregular poly(3-hexylthiophene) (P3HT) layers by 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane (F4-TCNQ) using infrared absorption spectroscopy in the multiple internal reflection geometry (MIR-IRAS) and conductivity measurements. IRAS data confirm that F4-TCNQ acts as an effective p-type dopant for P3HT; highly doped P3HT displayed an intense, broad absorption band due to polaron (“polaron band”) and a high carrier (hole) density which are indicative of the charge transfer between F4-TCNQ and P3HT. We demonstrate that the charge (hole) transferred from the dopant molecule is distributed along the P3HT polymer chain and spreads over at least 10 thiophene monomer units on the chain. From a comparison of the measured conductivity of F4-TCNQ-doped P3HT layers with the carrier density, we show that the carrier mobility is proportional to the concentration of carriers (holes), which suggests that F4-TCNQ doping induces the conformational change of P3HT polymer chains to enhance the mobility of holes in the films of the doped P3HTs.

  13. 3,3,6,6-Tetra-methyl-9-[6-(3,3,6,6-tetra-methyl-1,8-dioxo-2,3,4,5,6,7,8,9-octa-hydro-1H-xanthen-9-yl)pyridin-2-yl]-2,3,4,5,6,7,8,9-octa-hydro-1H-xanthene-1,8-dione.

    PubMed

    Abdelhamid, Antar A; Mohamed, Shaaban Kamel; Allahverdiyev, Mirze A; Gurbanov, Atash V; Ng, Seik Weng

    2011-04-01

    In the title mol-ecule, C(39)H(45)NO(6), the two tetra-methyl-octa-hydroxanthen-1,8-dione substituents are arranged approximately parallel to each other and approximately perpendicular to the plane of the pyridine ring. The six-membered xanthene rings adopt flattened boat conformations with the O and methine C atoms deviating from the plane of the other four atoms. PMID:21754076

  14. Hyperoxia depletes (6R)-5,6,7,8-tetrahydrobiopterin levels in the neonatal retina: implications for nitric oxide synthase function in retinopathy.

    PubMed

    Edgar, Kevin S; Matesanz, Nuria; Gardiner, Tom A; Katusic, Zvonimir S; McDonald, Denise M

    2015-06-01

    Retinopathy of prematurity is a sight-threatening complication of premature birth caused by nitro-oxidative insult to the developing retinal vasculature during therapeutic hyperoxia exposure and later ischemia-induced neovascularization on supplemental oxygen withdrawal. In the vasodegenerative phase, during hyperoxia, defective endothelial nitric oxide synthase (NOS) produces reactive oxygen and nitrogen free radicals rather than vasoprotective nitric oxide for unclear reasons. Crucially, normal NOS function depends on availability of the cofactor (6R)-5,6,7,8-tetrahydrobiopterin (BH4). Because BH4 synthesis is controlled enzymatically by GTP cyclohydrolase (GTPCH), we used GTPCH-depleted mice [hyperphenylalaninemia strain (hph1)] to investigate the impact of hyperoxia on BH4 bioavailability and retinal vascular pathology in the neonate. Hyperoxia decreased BH4 in retinas, lungs, and aortas in all experimental groups, resulting in a dose-dependent decrease in NOS activity and, in the wild-type group, elevated NOS-derived superoxide. Retinal dopamine levels were similarly diminished, consistent with the dependence of tyrosine hydroxylase on BH4. Despite greater depletion of BH4, the hph(+/-) and hph1(-/-) groups did not show exacerbated hyperoxia-induced vessel closure, but exhibited greater vascular protection and reduced progression to neovascular disease. This vasoprotective effect was independent of enhanced circulating vascular endothelial growth factor (VEGF), which was reduced by hyperoxia, but to local retinal ganglion cell layer-derived VEGF. In conclusion, a constitutively higher level of VEGF expression associated with retinal development protects GTPCH-deficient neonates from oxygen-induced vascular damage. PMID:25913075

  15. 47 CFR 2.108 - Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Policy regarding the use of the fixed-satellite... Allocation, Assignment, and Use of Radio Frequencies § 2.108 Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5.925 GHz bands. The use of the fixed-satellite allocations...

  16. 47 CFR 2.108 - Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Policy regarding the use of the fixed-satellite... Allocation, Assignment, and Use of Radio Frequencies § 2.108 Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5.925 GHz bands. The use of the fixed-satellite allocations...

  17. 47 CFR 2.108 - Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Policy regarding the use of the fixed-satellite... Allocation, Assignment, and Use of Radio Frequencies § 2.108 Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5.925 GHz bands. The use of the fixed-satellite allocations...

  18. 47 CFR 2.108 - Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Policy regarding the use of the fixed-satellite... Allocation, Assignment, and Use of Radio Frequencies § 2.108 Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5.925 GHz bands. The use of the fixed-satellite allocations...

  19. 47 CFR 2.108 - Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Policy regarding the use of the fixed-satellite... Allocation, Assignment, and Use of Radio Frequencies § 2.108 Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5.925 GHz bands. The use of the fixed-satellite allocations...

  20. Controlling Bulk Cu6Sn5 Nucleation in Sn0.7Cu/Cu Joints with Al Micro-alloying

    NASA Astrophysics Data System (ADS)

    Xian, J. W.; Belyakov, S. A.; Gourlay, C. M.

    2016-01-01

    We show that dilute Al additions can control the size of primary Cu6Sn5 rods in Sn-0.7Cu/Cu ball grid array joints. In Sn-0.7Cu-0.05Al/Cu joints, the number of primary Cu6Sn5 per mm2 is ˜7 times higher and the mean three-dimensional length of rods is ˜4 times smaller than in Al-free Sn-0.7Cu/Cu joints, while the area fraction of primary Cu6Sn5 is similar. It is shown that epitaxial nucleation of primary Cu6Sn5 occurs on δ-Cu33Al17 or γ 1-Cu9Al4 particles, which are stable in the Sn-0.7Cu-0.05Al melt during holding at 250°C. The observed facet relationships agree well with previously determined orientation relationships between δ-Cu33Al17 and Cu6Sn5 in hypereutectic Sn-Cu-Al alloys and result in a good lattice match with <˜2.5% lattice mismatch on two different interfacial planes.

  1. C,O-dialkylation of Meldrum's acid: synthesis and reactivity of 1,3,7,7-tetramethyl-4H,10H-6,8,9-trioxa-2-thiabenz[f]azulen-5-one.

    PubMed

    Snyder, Chad A; Selegue, John P; Dosunmu, Eniolami; Tice, Nathan C; Parkin, Sean

    2003-09-19

    Reaction of Meldrum's acid with 3,4-bis(chloromethyl)-2,5-dimethylthiophene (1) or 3,4-bis(bromomethyl)-2,5-dimethylthiophene (2) produces the kinetically favored C,O-dialkylation product, 1,3,7,7-tetramethyl-4H,10H-6,8,9-trioxa-2-thiabenz[f]azulen-5-one (4). Recrystallization of 4 from refluxing methanol results in the methanolysis product 5-(4-methoxymethyl-2,5-dimethylthiophen-3-ylmethyl)-2,2-dimethyl[1,3]dioxane-4,6-dione (5). Attempts to isomerize 4 to the thermodynamically favored C,C-dialkylation product, 1,3-dimethyl-5,6-dihydro-4H-cyclopenta[c]thiophene(2-spiro-5)2,2-dimethyl-4,6-dione (8), result in the formation of 1,3-dimethyl-7,8-dihydro-4H-thieno[3,4-c]oxepin-6-one (6). The transformation occurs via a retro-Diels-Alder elimination of acetone followed by hydrolysis and decarboxylation of the resulting ketene. The ketene is trapped by tert-butyl alcohol, furnishing 1,3-dimethyl-6-oxo-7,8-dihydro-4H,6H-thieno[3,4-c]oxepine-7-carboxylic acid tert-butyl ester (7). All compounds are characterized spectroscopically as well as by X-ray crystallography of products 4-7. PMID:12968900

  2. 6-Meth­oxy­meth­oxy-7-trifluoro­methyl-1,3-benzodioxole-5-carbaldehyde

    PubMed Central

    Wang, Yanfeng; Pan, Xinhui; Liu, Dexiu; Lou, Hong-Xiang

    2012-01-01

    The title compound, C11H9F3O5, crystallizes with three mol­ecules in the asymmetric unit. One –CF3 group is disordered by rotation, with the F atoms split over two sets of sites with occupancies which converged to 0.888 (6) and 0.112 (6). Weak π–π inter­actions are observed between adjacent benzene rings [the shortest centroid–centroid distance is 3.8858 (4) Å], resulting in the formation of a supra­molecular chain along [100]. PMID:22807814

  3. Atmospheric histories and growth trends of C4F10, C5F12, C6F14, C7F16 and C8F18

    NASA Astrophysics Data System (ADS)

    Ivy, D. J.; Arnold, T.; Harth, C. M.; Steele, L. P.; Mühle, J.; Rigby, M.; Salameh, P. K.; Leist, M.; Krummel, P. B.; Fraser, P. J.; Weiss, R. F.; Prinn, R. G.

    2012-05-01

    Atmospheric observations and trends are presented for the high molecular weight perfluorocarbons (PFCs): decafluorobutane (C4F10), dodecafluoropentane (C5F12), tetradecafluorohexane (C6F14), hexadecafluoroheptane (C7F16) and octadecafluorooctane (C8F18). Their atmospheric histories are based on measurements of 36 Northern Hemisphere and 46 Southern Hemisphere archived air samples collected between 1973 to 2011 using the Advanced Global Atmospheric Gases Experiment (AGAGE) "Medusa" preconcentration gas chromatography-mass spectrometry systems. A new calibration scale was prepared for each PFC, with estimated accuracies of 6.8% for C4F10, 7.8% for C5F12, 4.0% for C6F14, 6.6% for C7F16 and 7.9% for C8F18. Based on our observations the 2011 globally averaged dry air mole fractions of these heavy PFCs are: 0.17 parts-per-trillion (ppt, i.e., parts per 1012) for C4F10, 0.12 ppt for C5F12, 0.27 ppt for C6F14, 0.12 ppt for C7F16 and 0.09 ppt for C8F18. These atmospheric mole fractions combine to contribute to a global average radiative forcing of 0.35 mW m-2, which is 6% of the total anthropogenic PFC radiative forcing (Montzka and Reimann, 2011; Oram et al., 2012). The growth rates of the heavy perfluorocarbons were largest in the late 1990s peaking at 6.2 parts per quadrillion (ppq, i.e., parts per 1015) per year (yr) for C4F10, at 5.0 ppq yr-1 for C5F12 and 16.6 ppq yr-1 for C6F14 and in the early 1990s for C7F16 at 4.7 ppq yr-1 and in the mid 1990s for C8F18 at 4.8 ppq yr-1. The 2011 globally averaged mean atmospheric growth rates of these PFCs are subsequently lower at 2.2 ppq yr-1 for C4F10, 1.4 ppq yr-1 for C5F12, 5.0 ppq yr-1 for C6F14, 3.4 ppq yr-1 for C7F16 and 0.9 ppq yr-1 for C8F18. The more recent slowdown in the growth rates suggests that emissions are declining as compared to the 1980s and 1990s.

  4. Substituted 5,6-(Dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)-methanones as P2X7 Antagonists.

    PubMed

    Ziff, Jeannie; Rudolph, Dale A; Stenne, Brice; Koudriakova, Tatiana; Lord, Brian; Bonaventure, Pascal; Lovenberg, Timothy W; Carruthers, Nicholas I; Bhattacharya, Anindya; Letavic, Michael A; Shireman, Brock T

    2016-04-20

    We describe the synthesis of a novel class of brain penetrating P2X7 antagonists with high potency at both the rat and human P2X7 receptors. Disclosed herein are druglike molecules with demonstrated target engagement of the rat P2X7 receptors after an oral dose. Specifically, compound 20 occupied the P2X7 receptors >80% over the 6 h time course as measured by an ex vivo radioligand binding experiment. In a dose-response assay, this molecule has a plasma EC50 of 8 ng/mL. Overall, 20 has suitable druglike properties and pharmacokinetics in rat and dog. This molecule and others disclosed herein will serve as additional tools to elucidate the role of the P2X7 receptor in neuropsychiatric disorders. PMID:26754558

  5. Photoabsorption of the ground state of Ne and of Ne-like Na+, Mg2+, Al3+, Si4+, P5+, S6+, and Cl7+ ions

    NASA Astrophysics Data System (ADS)

    Sakho, I.

    2016-03-01

    Photoabsorption of the 1s2 2s2 2p6 (1S0) ground state of Ne-like ions is presented in this paper. Resonance energies and width of the 2 s 2p6 n p1P1 series of Ne and Ne-like Na+, Mg2+, Al3+, Si4+, P5+, S6+, and Cl7+ ions are reported. Wavelengths of the 2s2 2p6 (1S0) → 2s2 2p5(2P 3 / 2 , 1 / 2) n d transitions in neon-like Na+ ion and of the 2s2 2p6(1S0) → 2 s 2p6 n p1P1 transitions in Ne and in Ne-like Na+, Mg2+, Al3+, Si4+, P5+, S6+, and Cl7+ ions are tabulated. Analysis of the resonances investigated is done in the framework of the LS, jj and JK coupling schemes. All the calculations are made using the Screening constant by unit nuclear charge (SCUNC) formalism. Very good agreement is found between the SCUNC results and various experimental and theoretical literature values and new data for the Ne-like Si4+, P5+, S6+, and Cl7+ ions are listed.

  6. Synthesis of 2-arylamino substituted 5,6-dihydropyrido[2,3-d]pyrimidine-7(8H)-ones from arylguanidines.

    PubMed

    Galve, Iñaki; Puig de la Bellacasa, Raimon; Sánchez-García, David; Batllori, Xavier; Teixidó, Jordi; Borrell, José I

    2012-11-01

    A practical protocol was developed for the synthesis of 2-arylamino substituted 4-amino-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-ones from α,β-unsaturated esters, malononitrile, and an aryl substituted guanidine via the corresponding 3-aryl-3,4,5,6- tetrahydropyrido[2,3-d]pyrimidin-7(8H)-ones. Such compounds are formed upon treatment of 2-methoxy-6-oxo-1,4,5,6-tetrahydropyridine-3-carbonitriles with an aryl substituted guanidine in 1,4-dioxane and are converted to the desired 4-aminopyridopyrimidines with NaOMe/MeOH through a Dimroth rearrangement. The overall yields of this three-step protocol are, generally speaking, higher than the multicomponent reaction, previously developed by our group, between an α,β-unsaturated ester, malononitrile, and an aryl substituted guanidine. PMID:23054532

  7. 7. CONTEXTUAL VIEW NORTHEAST TOWARDS FEATURES 6 (LEFT) AND 7 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. CONTEXTUAL VIEW NORTHEAST TOWARDS FEATURES 6 (LEFT) AND 7 (RIGHT) WITHIN MILL COMPLEX. - Juniata Mill Complex, 22.5 miles Southwest of Hawthorne, between Aurora Crater & Aurora Peak, Hawthorne, Mineral County, NV

  8. Diastereoselective amidoalkylation of (3S,7aR)-6-benzyl-7-hydroxy-3-phenyltetra- hydro-5H-imidazo[1,5-c][1,3]thiazol-5-one: a short and highly efficient synthesis of (+)-biotin.

    PubMed

    Chavan, Subhash P; Chittiboyina, Amar G; Ravindranathan, T; Kamat, Subhash K; Kalkote, Uttam R

    2005-03-01

    A short and highly efficient synthesis of (+)-biotin in 10 steps with 20% overall yield has been achieved from L-cysteine involving amidoalkylation of hydroxy imidazothiazolone 4 via an acyliminium ion intermediate to furnish C-7-substituted imidazothiazolones 5b as the key step. PMID:15730318

  9. Synthesis, tumor inhibitory and antioxidant activity of new polyfunctionally 2-substituted 5,6,7,8-tetrahydronaphthalene derivatives containing pyridine, thioxopyridine and pyrazolopyridine moieties.

    PubMed

    Hamdy, Nehal A; Anwar, Manal M; Abu-Zied, Khadiga M; Awad, Hanem M

    2013-01-01

    2-Acetyl-5,6,7,8-tetrahydronaphthalene (1) was allowed to react with different aromatic aldehydes to produce the cyanopyridones 2a and 2b, which were treated with phosphorous pentasulfide to afford the corresponding thioxopyridine derivatives 3a and 3b, respectively. The reaction of 3a and 3b with ethyl bromoacetate afforded the ester derivatives 4a and 4b, while their condensation with hydrazine hydrate gave the corresponding pyrazolopyridine derivatives 5a and 5b. The reaction of the precursor 2-amino-5,6,7,8-tetrahydronaphthalene (6) with ethoxy methylenemalonic ester led to the formation of aminomethylenemalonate derivative 7. Cyclization of 7 in boiling diphenyl ether gave the derivative - ethyl 6,7,8,9-tetrahydro-4-hydroxybenzo[g]-quinoline-3-carboxylate (8) which was hydrolyzed to produce the corresponding carboxylic acid analogue 9. Further reaction of 3a with 3-chloropropane-1,2-diol and/or iodomethane produced the corresponding nicotinonitrile derivatives 10 and 11. Hydrazinolysis of derivative 11 gave the hydrazinyl derivative 12. Moreover, chlorination of compound 2a with phosphorous oxychloride led to 2-chloro nicotinonitrile derivative 13, which was refluxed with various amines to form the corresponding derivatives 5a, 14 and 15. Treatment of the pyrazolopyridine compound 5a with formic acid and acetic anhydride afforded the corresponding formamide and acetamide analogues 16 and 17, while its reaction with DMF-DMA yielded the corresponding formimidamide derivative 18. The pyridopyrazolo[1,5-a]pyrimidine derivative 19 was obtained by cyclization of 5a with acetyl acetone. The antioxidant activity evaluation of the newly synthesized compounds showed that the pyrazolopyridine derivative 5a exhibited scavenging potency higher than that obtained by ascorbic acid. Tumor inhibitory activity screening revealed that derivatives 8 and 10 showed promising potency against the liver cancer cells (HepG-2) compared to doxorubicin as a reference drug. PMID:24383322

  10. Inhibition of thalamic excitability by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol: a selective role for delta-GABA(A) receptors.

    PubMed

    Herd, Murray B; Foister, Nicola; Chandra, Dev; Peden, Dianne R; Homanics, Gregg E; Brown, Verity J; Balfour, David J K; Lambert, Jeremy J; Belelli, Delia

    2009-03-01

    The sedative and hypnotic agent 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol (THIP) is a GABA(A) receptor (GABA(A)R) agonist that preferentially activates delta-subunit-containing GABA(A)Rs (delta-GABA(A)Rs). To clarify the role of delta-GABA(A)Rs in mediating the sedative actions of THIP, we utilized mice lacking the alpha(1)- or delta-subunit in a combined electrophysiological and behavioural analysis. Whole-cell patch-clamp recordings were obtained from ventrobasal thalamic nucleus (VB) neurones at a holding potential of -60 mV. Application of bicuculline to wild-type (WT) VB neurones revealed a GABA(A)R-mediated tonic current of 92 +/- 19 pA, which was greatly reduced (13 +/- 5 pA) for VB neurones of delta(0/0) mice. Deletion of the delta- but not the alpha(1)-subunit dramatically reduced the THIP (1 mum)-induced inward current in these neurones (WT, -309 +/- 23 pA; delta(0/0), -18 +/- 3 pA; alpha(1) (0/0), -377 +/- 45 pA). Furthermore, THIP selectively decreased the excitability of WT and alpha(1) (0/0) but not delta(0/0) VB neurones. THIP did not affect the properties of miniature inhibitory post-synaptic currents in any of the genotypes. No differences in rotarod performance and locomotor activity were observed across the three genotypes. In WT mice, performance of these behaviours was impaired by THIP in a dose-dependent manner. The effect of THIP on rotarod performance was blunted for delta(0/0) but not alpha(1) (0/0) mice. We previously reported that deletion of the alpha(1)-subunit abolished synaptic GABA(A) responses of VB neurones. Therefore, collectively, these findings suggest that extrasynaptic delta-GABA(A)Rs vs. synaptic alpha(1)-subunit-containing GABA(A)Rs of thalamocortical neurones represent an important molecular target underpinning the sedative actions of THIP. PMID:19302153

  11. Atmospheric histories and growth trends of C4F10, C5F12, C6F14, C7F16 and C8F18

    NASA Astrophysics Data System (ADS)

    Ivy, D. J.; Arnold, T.; Harth, C. M.; Steele, L. P.; Mühle, J.; Rigby, M.; Salameh, P. K.; Leist, M.; Krummel, P. B.; Fraser, P. J.; Weiss, R. F.; Prinn, R. G.

    2012-02-01

    The first atmospheric observations and trends are presented for the high molecular weight perfluorocarbons (PFCs): decafluorobutane (C4F10), dodecafluoropentane (C5F12), tetradecafluorohexane (C6F14), hexadecafluoroheptane (C7F16) and octadecafluorooctane (C8F18). Their atmospheric histories are based on measurements of 38 Northern Hemisphere and 46 Southern Hemisphere archived air samples collected between 1973 to 2011 using the Advanced Global Atmospheric Gases Experiment (AGAGE) "Medusa" preconcentration gas chromatography-mass spectrometry systems. A new calibration scale was prepared for each PFC, with estimated accuracies of 6.8% for C4F10, 7.8% for C5F12, 4.0% for C6F14, 6.6% for C7F16 and 7.9% for C8F18. Based on our observations the 2011 globally averaged dry air mole fractions of these heavy PFCs are: 0.18 parts-per-trillion (ppt, i.e., parts per 1012) for C4F10, 0.12 ppt for C5F12, 0.28 ppt for C6F14, 0.12 ppt for C7F16 and 0.09 ppt for C8F18. These atmospheric mole fractions combine to contribute to a global average radiative forcing of 0.35 mW m-2, which is 3.6% of the total PFC radiative forcing. The globally averaged mean atmospheric growth rates of these PFCs during 1973-2011 are 4.58 parts per quadrillion (ppq, i.e., parts per 1015) per year (yr) for C4F10, 3.29 ppq yr-1 for C5F12, 7.50 ppq yr-1 for C6F14, 3.19 ppq yr-1 for C7F16 and 2.51 ppq yr-1 for C8F18. The growth rates of the heavy perfluorocarbons were largest in the early 1990s for C4F10 and C5F12 and in the mid-to-late 1990s for C6F14, C7F16 and C8F18. The more recent slow down in the growth rates of the high molecular weight PFCs suggests that emissions are declining as compared to the 1980s and 1990s. Nevertheless continued monitoring of these potent, extremely long-lived greenhouse gases is necessary to verify that global PFC emissions continue to decline.

  12. Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists.

    PubMed

    Rudolph, Dale A; Alcazar, Jesus; Ameriks, Michael K; Anton, Ana Belen; Ao, Hong; Bonaventure, Pascal; Carruthers, Nicholas I; Chrovian, Christa C; De Angelis, Meri; Lord, Brian; Rech, Jason C; Wang, Qi; Bhattacharya, Anindya; Andres, Jose Ignacio; Letavic, Michael A

    2015-08-15

    The optimization efforts that led to a novel series of methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones that are potent rat and human P2X7 antagonists are described. These efforts resulted in the discovery of compounds with good drug-like properties that are capable of high P2X7 receptor occupancy in rat following oral administration, including compounds 7n (P2X7 IC50 = 7.7 nM) and 7u (P2X7 IC50 =7 .7 nM). These compounds are expected to be useful tools for characterizing the effects of P2X7 antagonism in models of depression and epilepsy, and several of the compounds prepared are candidates for effective P2X7 PET tracers. PMID:26099534

  13. Eight-position substitution effects on laser action of the 1,3,5,7-tetramethyl-2,6-diethyl pyrromethene-BF2 complexes

    NASA Astrophysics Data System (ADS)

    Liang, Feng; Zeng, Heping; Sun, Zhenrong; Yuan, Yizhong; Yao, Zuguang; Xu, Zhizhan

    2001-12-01

    We measured laser-action properties of some novel eight-position substituted 1,3,5,7-tetramethyl-2,6-diethyl pyrromethene-BF2 complexes in a Littman-type cavity pumped by the second harmonic of a Q-switched Nd:YAG laser. The substitution effects were investigated by comparing the spectroscopic and laser-action properties of various eight-position substituted complexes, such as absorption, excitation, and fluorescence emission, and triplet-triplet absorption spectra, dye-laser wavelength-tuning spectra, and output-pulse energy versus the pump-laser energy. The results showed that 1,3,5,7-tetramethyl-2,6-diethyl pyrromethene-BF2 complexes with phenyl, p-methoxyphenyl, and p-fluorophenyl substituted at the eight-position outperformed the commercially available benchmark laser dye Rhodamine 6G (Rh6G) in fluorescence quantum yields, laser efficiency, and laser wavelength-tuning range.

  14. Reaction of (chloro carbonyl) phenyl ketene with 5-amino pyrazolones: Synthesis, characterization and theoretical studies of 7-hydroxy-6-phenyl-3-(phenyldiazenyl)pyrazolo[1,5-a]pyrimidine-2,5(1H,4H)-dione derivatives

    NASA Astrophysics Data System (ADS)

    Zahedifar, Mahboobeh; Razavi, Razieh; Sheibani, Hassan

    2016-12-01

    New 7-hydroxy-6-phenyl-3-(phenyldiazenyl)pyrazolo[1,5-a]pyrimidine-2,5(1H,4H)-dione derivatives were synthesized from the reaction of (chlorocarbonyl)phenyl ketene and 5-amino pyrazolones in high to excellent yields and short reaction times. Structures of the new compounds were fully characterized by their spectral data IR, 1H NMR, and 13C NMR and by the theoretical results. Density Functional Theory (DFT) was used to optimize the structures, compute the energies and vibrational frequencies IR and 1H NMR shielding tensors of the desired products. The theoretical results excellent are compared with the experimental data.

  15. The high stability of boron-doped lithium clusters Li 5B, Li 6B +/- and Li 7B: A case of the phenomenological shell model

    NASA Astrophysics Data System (ADS)

    Tai, Truong Ba; Nguyen, Minh Tho

    2010-04-01

    A quantum chemical investigation of the clusters Li 5B, Li 6B +, Li 6B - and Li 7B was performed using the DFT, MP2 and CCSD(T) methods. The high symmetry structures ( C4v, 1A 1), ( Oh, 1A 1g) and ( D5h, 1A1') turnout to be the global minima for Li 5B, Li 6B + and Li 7B, respectively. These clusters are predicted to be highly stable species with large vertical ionization energies, and large HOMO-LUMO gaps. Chemical bonding of clusters was probed using an electron localizability indicator (ELI) which indicates a large aromatic character. The high stability of these clusters can be accounted for by the phenomenological shell model.

  16. Copper-catalyzed cascade cyclization of 1,7-enynes with aromatic sulfonyl chlorides toward selective assembly of benzo[j]phenanthridin-6(5H)-ones.

    PubMed

    Liu, Yu; Zhang, Jia-Ling; Zhou, Ming-Bo; Song, Ren-Jie; Li, Jin-Heng

    2014-11-28

    A step-economical method for the cascade cyclization of 1,7-enynes with aromatic sulfonyl chlorides by using a low-cost and more abundant Cu catalyst is presented. This method allows access to benzo[j]phenanthridin-6(5H)-ones and represents a new Cu-catalyzed cascade cyclization of 1,n-enynes. PMID:25300349

  17. X-ray Mapping in Heterocyclic Design: XIV. Tricyclic Heterocycles Based on 2-Oxo-1,2,5,6,7,8-Hexahydroquinoline-3-Carbonitrile

    SciTech Connect

    Mazina, O.S.; Rybakov, V.B.; Chernyshev, V.V.; Babaev, E.V.; Aslanov, L.A.

    2004-11-01

    The structures of four compounds are studied using single-crystal X-ray diffraction: 1-[2-(4-chlorophenyl)-2-oxoethyl]-2-oxo-1,2,5,6,7,8-hexahydroquinoline -3-carbonitrile [a = 4.908(4) A, b = 11.644(10) A, c = 13.587(2) A, {beta} = 94.31(5) deg., Z = 2, space group P2{sub 1}]; 2-[2-(4-chlorophenyl)-2-oxoethoxy]-5,6,7,8-tetrahydroquinoline -3-carbonitrile [a = 7.6142(8) A, b = 14.778(2) A, c = 14.132(2) A, {beta} = 100.38(1) deg., Z = 4, space group P2{sub 1}/c]; 4-(aminocarbonyl)-2-(chlorophenyl)-6,7,8,9-tetrahydro[1.3]oxazolo[3,2-a] quinolin-3-ium perchlorate [a = 5.589(7) A, b = 24.724(15) A, c = 13.727(5) A, {beta} = 97.66(9) deg., Z = 4, space group P2{sub 1}/n]; and (3-amino-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-2-yl)-(4-chlorophenyl) methanone [a = 7.150(2) A, b = 7.4288(10) A, c = 15.314(3) A, {alpha} = 98.030(10) deg., {beta} = 99.21(2) deg., {gamma} = 105.34(2) deg., Z = 2, space group P1-bar]. The structures are solved by direct methods and refined by the full-matrix least-squares procedure in the anisotropic approximation to R = 0.0728, 0.0439, 0.1228, and 0.0541, respectively. The structure of 1-(4-chlorophenyl)-4-piperidin-1-yl-8,9-dihydro-7H-pyrrolo[3.2.1-ij] quinoline-5-carboxamide [a = 23.9895(9) A, b = 5.1557(3) A, c = 17.0959(9) A, {beta} = 106.43 deg., Z = 4, space group P{sub 1}/c] is investigated by X-ray powder diffraction. This structure is solved using the grid search procedure and refined by the Rietveld method to R{sub wp} = 0.0773, R{sub exp} = 0.0540, R{sub p} = 0.0585, R{sub b} = 0.1107, and {chi}{sup 2} = 1.78.

  18. On the reactivity of 6-acetyl-7-(2-dimethylaminovinyl)pyrazolo[1,5-a]pyrimidines with 1,3- and 1,4-bisnucleophiles.

    PubMed

    Chimichi, Stefano; Boccalini, Marco; Selleri, Silvia; Costagli, Camilla; Guerrini, Gabriella; Viola, Giampietro

    2008-02-21

    Reaction of 6-acetyl-7-(2-dimethylaminovinyl)pyrazolo[1,5-a]pyrimidine 1 with 1,3- and 1,4-bisnucleophiles has been investigated; obtainment of new polycyclic heterocyclic derivatives is reported. A convenient procedure leading to new pyrazolo[1,5-a]quinazolines is described; a modest bioactivity of these compounds against two human tumor cell lines was also ascertained. PMID:18264575

  19. New metal-organic frameworks of [M(C{sub 6}H{sub 5}O{sub 7})(C{sub 6}H{sub 6}O{sub 7})(C{sub 6}H{sub 7}O{sub 7})(H{sub 2}O)] . H{sub 2}O (M=La, Ce) and [Ce{sub 2}(C{sub 2}O{sub 4})(C{sub 6}H{sub 6}O{sub 7}){sub 2}] . 4H{sub 2}O

    SciTech Connect

    Weng Shengfeng; Wang, Yun-Hsin; Lee, Chi-Shen

    2012-04-15

    Two novel materials, [M(C{sub 6}H{sub 5}O{sub 7})(C{sub 6}H{sub 6}O{sub 7})(C{sub 6}H{sub 7}O{sub 7})(H{sub 2}O)] . H{sub 2}O (M=La(1a), Ce(1b)) and [Ce{sub 2}(C{sub 2}O{sub 4})(C{sub 6}H{sub 6}O{sub 7}){sub 2}] . 4H{sub 2}O (2), with a metal-organic framework (MOF) were prepared with hydrothermal reactions and characterized with photoluminescence, magnetic susceptibility, thermogravimetric analysis and X-ray powder diffraction in situ. The crystal structures were determined by single-crystal X-ray diffraction. Compound 1 crystallized in triclinic space group P1-bar (No. 2); compound 2 crystallized in monoclinic space group P2{sub 1}/c (No. 14). The structure of 1 is built from a 1D MOF, composed of deprotonated citric ligands of three kinds. Compound 2 contains a 2D MOF structure consisting of citrate and oxalate ligands; the oxalate ligand arose from the decomposition in situ of citric acid in the presence of Cu{sup II} ions. Photoluminescence spectra of compounds 1b and 2 revealed transitions between the 5d{sup 1} excited state and two levels of the 4f{sup 1} ground state ({sup 2}F{sub 5/2} and {sup 2}F{sub 7/2}). Compounds 1b and 2 containing Ce{sup III} ion exhibit a paramagnetic property with weak antiferromagnetic interactions between the two adjacent magnetic centers. - Graphical Abstract: [M(C{sub 6}H{sub 5}O{sub 7})(C{sub 6}H{sub 6}O{sub 7})(C{sub 6}H{sub 7}O{sub 7})(H{sub 2}O)] . H{sub 2}O (M=La(1a), Ce(1b)) and [Ce{sub 2}(C{sub 2}O{sub 4})(C{sub 6}H{sub 6}O{sub 7}){sub 2}] . 4H{sub 2}O (2)-with 1D and 2D structures were synthesized and characterized. Highlights: Black-Right-Pointing-Pointer Two MOF - [M(C{sub 6}H{sub 5}O{sub 7})(C{sub 6}H{sub 6}O{sub 7})(C{sub 6}H{sub 7}O{sub 7})(H{sub 2}O)] . H{sub 2}O (M=La(1a), Ce(1b)) and [Ce{sub 2}(C{sub 2}O{sub 4})(C{sub 6}H{sub 6}O{sub 7}){sub 2}] . 4H{sub 2}O (2) - with 1D and 2D structures. Black-Right-Pointing-Pointer The adjacent chains of the 1D framework were correlated with each other through an oxalate

  20. 4-Imino-2,7-dimethyl-5,6,7,8-tetra-hydro-4H-1-benzothieno[2,3-d]pyrimidin-3-amine.

    PubMed

    Kalashetti, Mallikarjun B; Fathima, Nikhath; Khan, Ashraf Y; Begum, Noor Shahina; Khazi, I M

    2012-08-01

    In the title compound, C(12)H(16)N(4)S, the fused benzothio-phene and the pyrimidine rings are coplanar [dihedral angle = 1.61 (6)°]. Three C atoms of the cyclohexene ring (at positions 3, 6 and 7) are disordered over two sites with an occupancy ratio of 0.702 (8):0.298 (8). The cyclo-hexene ring in both the major and minor components adopts a half-chair conformation. The crystal structure is stabilized by N-H⋯N and C-H⋯N inter-actions, resulting in the formation of inversion dimers with R(2) (2)(10) and R(2) (2)(12) graph-set motifs. PMID:22904911

  1. Review of variations in Mw < 7 earthquake motions on position and tec (Mw = 6.5 aegean sea earthquake sample)

    NASA Astrophysics Data System (ADS)

    Yildirim, O.; Inyurt, S.; Mekik, C.

    2015-10-01

    Turkey is a country located in Middle Latitude zone and in which tectonic activity is intensive. Lastly, an earthquake of magnitude 6.5Mw occurred at Aegean Sea offshore on date 24 May 2014 at 12:25 UTC and it lasted approximately 40 s. The said earthquake was felt also in Greece, Romania and Bulgaria in addition to Turkey. In recent years seismic origin ionospheric anomaly detection studies have been done with TEC (Total Electron Contents) generated from GNSS (Global Navigation Satellite System) signals and the findings obtained have been revealed. In this study, TEC and positional variations have been examined seperately regarding the earthquake which occurred in the Aegean Sea. Then The correlation of the said ionospheric variation with the positional variation has been investigated. For this purpose, total fifteen stations have been used among which the data of four numbers of CORS-TR stations in the seismic zone (AYVL, CANA, IPSA, YENC) and IGS and EUREF stations are used. The ionospheric and positional variations of AYVL, CANA, IPSA and YENC stations have been examined by Bernese 5.0v software. When the (PPP-TEC) values produced as result of the analysis are examined, it has been understood that in the four stations located in Turkey, three days before the earthquake at 08:00 and 10:00 UTC, the TEC values were approximately 4 TECU above the upper limit TEC value. Still in the same stations, one day before the earthquake at 06:00, 08:00 and 10:00 UTC, it is being shown that the TEC values were approximately 5 TECU below the lower limit TEC value. On the other hand, the GIM-TEC values published by the CODE center have been examined. Still in all stations, it has been observed that three days before the earthquake the TEC values in the time portions of 08:00 and 10:00 UTC were approximately 2 TECU above, one day before the earthquake at 06:00, 08:00 and 10:00 UTC, the TEC values were approximately 4 TECU below the lower limit TEC value. Again, by using the same

  2. Review of variations in Mw < 7 earthquake motions on position and TEC (Mw = 6.5 Aegean Sea earthquake sample)

    NASA Astrophysics Data System (ADS)

    Yildirim, Omer; Inyurt, Samed; Mekik, Cetin

    2016-02-01

    Turkey is a country located in the middle latitude zone, where tectonic activity is intensive. Recently, an earthquake of magnitude 6.5 Mw occurred offshore in the Aegean Sea on 24 May 2014 at 09:25 UTC, which lasted about 40 s. The earthquake was also felt in Greece, Romania, and Bulgaria in addition to Turkey. In recent years, ionospheric anomaly detection studies have been carried out because of seismicity with total electron content (TEC) computed from the global navigation satellite system's (GNSS) signal delays and several interesting findings have been published. In this study, both TEC and positional variations have been examined separately following a moderate size earthquake in the Aegean Sea. The correlation of the aforementioned ionospheric variation with the positional variation has also been investigated. For this purpose, a total of 15 stations was used, including four continuously operating reference stations in Turkey (CORS-TR) and stations in the seismic zone (AYVL, CANA, IPSA, and YENC), as well as international GNSS service (IGS) and European reference frame permanent network (EPN) stations. The ionospheric and positional variations of the AYVL, CANA, IPSA, and YENC stations were examined using Bernese v5.0 software. When the precise point positioning TEC (PPP-TEC) values were examined, it was observed that the TEC values were approximately 4 TECU (total electron content unit) above the upper-limit TEC value at four stations located in Turkey, 3 days before the earthquake at 08:00 and 10:00 UTC. At the same stations, on the day before the earthquake at 06:00, 08:00, and 10:00 UTC, the TEC values were approximately 5 TECU below the lower-limit TEC value. The global ionosphere model TEC (GIM-TEC) values published by the Centre for Orbit Determination in Europe (CODE) were also examined. Three days before the earthquake, at all stations, it was observed that the TEC values in the time period between 08:00 and 10:00 UTC were approximately 2 TECU

  3. Synthesis, in vitro antimycobacterial evaluation and docking studies of some new 5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one schiff bases.

    PubMed

    Malothu, Narender; Bhandaru, Jaswanth S; Kulandaivelu, Umasankar; Jojula, Malathi; Adidala, Raghuram Reddy; K R, Umadevi; A V N, Dusthackeer; Kaki, Venkat Rao; Akkinepally, Raghuram R

    2016-02-01

    Development of multidrug resistant (MDR) and extensively drug resistant (XDR) tuberculosis (TB) has been considered as major health burden, globally. In order to develop novel, potential molecules against drug resistant TB, twenty two (22) new 3-substituted-7-benzyl-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one (6a-k) and 3-substituted-7-benzyl-2-methyl-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one (7a-k) derivatives were designed and synthesized by using appropriate synthetic protocols. Pantothenate synthetase (PS) was considered as the target for the molecular docking studies and evaluated the binding pattern at active site, as PS plays a significant role in the biosynthesis of pantothenate in Mycobacterium tuberculosis (MTB). The preliminary in vitro antibacterial screening of test compounds was carried out against two strains of Gram-positive (Bacillus subtilis and Staphylococcus aureus) and Gram-negative (Escherichia coli and Klebsiella pneumoniae) bacteria. The antimycobacterial screening was performed against MTB H37Rv and an isoniazid-resistant clinical isolate of MTB. The compounds 6b, 6c, 6d, 6k, 7b, 7c, 7d and 7k exhibited promising antibacterial activity MIC in the range of 15-73 μM against all bacterial strains used and compounds 6d and 7b showed antimycobacterial activity (IC50 <340 μM in LRP assay) and (MIC <9 μM in broth microdilution method). PMID:26755393

  4. Suppression of Adipogenesis by 5-Hydroxy-3,6,7,8,3',4'-Hexamethoxyflavone from Orange Peel in 3T3-L1 Cells.

    PubMed

    Wang, Yu; Lee, Pei-Sheng; Chen, Yi-Fen; Ho, Chi-Tang; Pan, Min-Hsiung

    2016-09-01

    We reported previously that hydroxylated polymethoxyflavones (HPMFs) effectively suppressed obesity in high-fat-induced mouse. In this study, we further investigated the molecular mechanism of action of 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone (5-OH-HxMF), one of major HPMFs in orange peel. Treatment of 5-OH-HxMF effectively inhibited lipid accumulation by 55-60% in a dose-dependent manner. The 5-OH-HxMF attenuated adipogenesis through downregulating adipogenesis-related transcription factors such as peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT/enhancer-binding proteins (C/EBPs), as well as downstream target fatty acid synthase and acetyl-CoA carboxylase (ACC). 5-OH-HxMF activated adenosine monophosphate-activated protein kinase signaling and silent mating type information regulation 1 (SIRTUIN 1 or SIRT1) in 3T3-L1 adipocytes to decrease lipid accumulation. In addition, the inhibition rate of lipid accumulation was compared between 5-OH-HxMF and 3,5,6,7,8,3',4'-heptamethoxyflavone (HpMF). 5-OH-HxMF inhibited lipid accumulation 15-20% more than HpMF did, indicating that hydroxyl group at position 5 can be a key factor in the suppression of adipogenesis. PMID:27542074

  5. Ethyl 2,7,7-trimethyl-4-(1-methyl-1H-indol-3-yl)-5-oxo-1,4,5,6,7,8-hexa-hydro-quinoline-3-carboxyl-ate.

    PubMed

    Oztürk Yildirim, Sema; Butcher, Ray J; Gündüz, Miyase Gözde; El-Khouly, Ahmed; Simşek, Rahime; Safak, Cihat

    2013-01-01

    In the title mol-ecule, C24H28N2O3, the cyclo-hexene ring is in a sofa conformation and the 1,4-dihydro-pyridine ring is in a slight boat conformation. In the indole ring system, the pyrrole and benzene rings form a dihedral angle of 2.63 (7)°. In the crystal, N-H⋯O hydrogen bonds connect the mol-ecules into C(6) chains parallel to the b axis and pairs of weak C-H⋯O hydrogen bonds link inversion-related chains into a ladder motif through R2(2)(18) rings. A weak intra-molecular C-H⋯O hydrogen bond is also observed. PMID:23476426

  6. The galaxy luminosity function at z ≃ 6 and evidence for rapid evolution in the bright end from z ≃ 7 to 5

    NASA Astrophysics Data System (ADS)

    Bowler, R. A. A.; Dunlop, J. S.; McLure, R. J.; McCracken, H. J.; Milvang-Jensen, B.; Furusawa, H.; Taniguchi, Y.; Le Fèvre, O.; Fynbo, J. P. U.; Jarvis, M. J.; Häußler, B.

    2015-09-01

    We present the results of a search for bright (-22.7 ≤ MUV ≤ -20.5) Lyman-break galaxies at z ≃ 6 within a total of 1.65 deg2 of imaging in the UltraVISTA/Cosmological Evolution Survey (COSMOS) and United Kingdom Infrared Telescope Deep Sky Survey (UKIDSS) Ultra Deep Survey (UDS) fields. The deep near-infrared imaging available in the two independent fields, in addition to deep optical (including z'-band) data, enables the sample of z ≃ 6 star-forming galaxies to be securely detected longward of the break (in contrast to several previous studies). We show that the expected contamination rate of our initial sample by cool Galactic brown dwarfs is ≲3 per cent and demonstrate that they can be effectively removed by fitting brown dwarf spectral templates to the photometry. At z ≃ 6, the galaxy surface density in the UltraVISTA field exceeds that in the UDS by a factor of ≃ 1.8, indicating strong cosmic variance even between degree-scale fields at z > 5. We calculate the bright end of the rest-frame Ultraviolet (UV) luminosity function (LF) at z ≃ 6. The galaxy number counts are a factor of ˜1.7 lower than predicted by the recent LF determination by Bouwens et al. In comparison to other smaller area studies, we find an evolution in the characteristic magnitude between z ≃ 5 and z ≃ 7 of ΔM* ˜ 0.4, and show that a double power law or a Schechter function can equally well describe the LF at z = 6. Furthermore, the bright end of the LF appears to steepen from z ≃ 7 to z ≃ 5, which could indicate the onset of mass quenching or the rise of dust obscuration, a conclusion supported by comparing the observed LFs to a range of theoretical model predictions.

  7. Benzene-1,2,4,5-tetra-carb-oxy-lic acid bis-(1,3,7-trimethyl-2,3,6,7-tetra-hydro-1H-purine-2,6-dione).

    PubMed

    Arman, Hadi D; Tiekink, Edward R T

    2013-01-01

    The asymmetric unit of the title co-crystal, C10H6O8·2C8H10N4O2, comprises a centrosymmetric benzene-1,2,4,5-tetra-carb-oxy-lic acid (LH4) mol-ecule and a mol-ecule of caffeine in a general position. LH4 is nonplanar, with the dihedral angles between the ring and pendent carb-oxy-lic acid groups being 44.22 (7) and 49.74 (7)°. By contrast, the caffeine mol-ecule is planar (r.m.s. deviation = 0.040 Å). Supra-molecular layers parallel to (-1-10) are sustained by carb-oxy-lic acid O-H⋯O(carbon-yl) and O-H⋯N(imidazole) hydrogen bonds, as well as by meth-yl-carbonyl C-H⋯O inter-actions. These stack via π-π inter-actions between the benzene and imidazole rings [inter-centroid distance = 3.4503 (10) Å]. PMID:24427071

  8. The thermodynamic properties of 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene. [Tetrahydropyrene and hexahydropyrene

    SciTech Connect

    Chirico, R.D.; Knipmeyer, S.E.; Nguyen, A.; Smith, N.K.; Steele, W.V.

    1992-12-01

    Measurements leading to the calculation of the ideal-gas thermodynamic properties are reported for 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene. Experimental methods included combustion calorimetry, adiabatic heat-capacity calorimetry, vibrating-tube densitometry, comparative ebulliometry, inclined-piston gauge manometry, and differential-scanning calorimetry (d.s.c.). Critical properties were estimated for both materials based on the measurement results. Entropies, enthalpies, and Gibbs energies of formation were derived for the ideal gases for selected temperatures between 380 K and 700 K. The property-measurement results reported here for 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene are the first for these important intermediates in the pyrene/H[sub 2] hydrogenation reaction network.

  9. Synthesis, spectroscopic characterization, X-ray structure and DFT studies on 4-(2-hydroxyphenyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-5-ium chloride hydrate.

    PubMed

    Türkyılmaz, Murat; Özdemir, Namık; Baran, Yakup

    2011-11-01

    The title molecular salt, 4-(2-hydroxyphenyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-5-ium chloride hydrate (C(12)H(14)N(3)O(+)·Cl-·H(2)O), was synthesized and characterized by IR-NMR spectroscopy and single-crystal X-ray diffraction. In addition to the molecular geometry from X-ray experiment, the molecular geometry, vibrational frequencies and gauge-independent atomic orbital (GIAO) (1)H and (13)C NMR chemical shift values of the title compound in the ground state have been calculated using the density functional theory (DFT/B3LYP) method with the 6-31++G(d,p) and 6-311++G(d,p) basis sets, and compared with the experimental data. Besides, molecular electrostatic potential (MEP) distribution and non-linear optical properties of the title compound were investigated by theoretical calculations at the B3LYP/6-311++G(d,p) level. PMID:21820352

  10. Synthesis, spectroscopic characterization, X-ray structure and DFT studies on 4-(2-hydroxyphenyl)-4,5,6,7-tetrahydro-1 H-imidazo[4,5- c]pyridin-5-ium chloride hydrate

    NASA Astrophysics Data System (ADS)

    Türkyılmaz, Murat; Özdemir, Namık; Baran, Yakup

    2011-11-01

    The title molecular salt, 4-(2-hydroxyphenyl)-4,5,6,7-tetrahydro-1 H-imidazo[4,5- c]pyridin-5-ium chloride hydrate (C 12H 14N 3O +·Clˉ·H 2O), was synthesized and characterized by IR-NMR spectroscopy and single-crystal X-ray diffraction. In addition to the molecular geometry from X-ray experiment, the molecular geometry, vibrational frequencies and gauge-independent atomic orbital (GIAO) 1H and 13C NMR chemical shift values of the title compound in the ground state have been calculated using the density functional theory (DFT/B3LYP) method with the 6-31++G(d,p) and 6-311++G(d,p) basis sets, and compared with the experimental data. Besides, molecular electrostatic potential (MEP) distribution and non-linear optical properties of the title compound were investigated by theoretical calculations at the B3LYP/6-311++G(d,p) level.

  11. New detections of HC5N towards hot cores associated with 6.7 GHz methanol masers

    NASA Astrophysics Data System (ADS)

    Green, C.-E.; Green, J. A.; Burton, M. G.; Horiuchi, S.; Tothill, N. F. H.; Walsh, A. J.; Purcell, C. R.; Lovell, J. E. J.; Millar, T. J.

    2014-09-01

    We present new detections of cyanodiacetylene (HC5N) towards hot molecular cores, observed with the Tidbinbilla 34 m radio telescope (DSS-34). In a sample of 79 hot molecular cores, HC5N was detected towards 35. These results are counter to the expectation that long chain cyanopolyynes, such as HC5N, are not typically found in hot molecular cores, unlike their shorter chain counterpart HC3N. However, it is consistent with recent models which suggest HC5N may exist for a limited period during the evolution of hot molecular cores.

  12. 7 CFR 353.6 - Inspection.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 5 2012-01-01 2012-01-01 false Inspection. 353.6 Section 353.6 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORT CERTIFICATION § 353.6 Inspection. Inspections shall be performed by agents, by inspectors, or by employees of a State...

  13. 7 CFR 983.6 - Assessed weight.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Assessed weight. 983.6 Section 983.6 Agriculture..., ARIZONA, AND NEW MEXICO Definitions § 983.6 Assessed weight. Assessed weight means pounds of inshell pistachios, with the weight computed at 5 percent moisture, received for processing by a handler within...

  14. 7 CFR 983.6 - Assessed weight.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Assessed weight. 983.6 Section 983.6 Agriculture..., ARIZONA, AND NEW MEXICO Definitions § 983.6 Assessed weight. Assessed weight means pounds of inshell pistachios, with the weight computed at 5 percent moisture, received for processing by a handler within...

  15. 7 CFR 371.6 - Wildlife Services.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 5 2011-01-01 2011-01-01 false Wildlife Services. 371.6 Section 371.6 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ORGANIZATION, FUNCTIONS, AND DELEGATIONS OF AUTHORITY § 371.6 Wildlife Services....

  16. 7 CFR 371.6 - Wildlife Services.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Wildlife Services. 371.6 Section 371.6 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ORGANIZATION, FUNCTIONS, AND DELEGATIONS OF AUTHORITY § 371.6 Wildlife Services....

  17. 7 CFR 371.6 - Wildlife Services.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 5 2014-01-01 2014-01-01 false Wildlife Services. 371.6 Section 371.6 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ORGANIZATION, FUNCTIONS, AND DELEGATIONS OF AUTHORITY § 371.6 Wildlife Services....

  18. Adenosine deaminase inhibitors. Synthesis and biological evaluation of (+/-)-3,6,7,8-tetrahydro-3-[(2-hydroxyethoxy)methyl]imidazo[4,5-d] [1,3]diazepin-8-ol and some selected C-5 homologues of pentostatin.

    PubMed

    Showalter, H D; Putt, S R; Borondy, P E; Shillis, J L

    1983-10-01

    The synthesis of several analogues of (8R)-3-(2-deoxy-beta-D-erythro- pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol (pentostatin, 1a) is described. Ring closure of 2-amino-1-(5-amino-1H-imidazol-4-yl)ethanone dihydrochloride (3) with triethyl orthoacetate or triethyl orthopropionate gave the C-5 methyl and ethyl ketoaglycons, 6,7-dihydro-5-methylimidazo[4,5-d][1,3]diazepin-8(3H)-one (4b) and 5-ethyl-6,7-dihydroimidazo[4,5-d][1,3]diazepin-8(3H)-one (4c), respectively. Stannic chloride catalyzed condensation of the pertrimethylsilyl derivatives of 4b and 4c with a protected glycosyl halide afforded anomeric mixtures of ketonucleosides 3-(2-deoxy-3,5-di-O-p-toluoyl-beta- and -alpha-D-erythro-pentofuranosyl)-6,7-dihydro-5-methylimidazo[4,5-d] [1,3]diazepin-8(3H)-one (5b and 6b) and 3-(2-deoxy-3,5-di-O-p-toluoyl)-beta- and -alpha-D-erythro-pentofuranosyl)-5-ethyl-6,7-dihydroimidazo[4,5-d]- [1,3]diazepin-8(3H)-one (5c and 6c), respectively. Subsequent separation of the anomers, followed by deprotection and reduction of 5b, 6b, and 5c, afforded the respective 8R and 8S isomers. Stannic chloride catalyzed condensation of pertrimethylsilyl ketoaglycon 4a with 2-(chloromethoxy)-1-(p-toluoyloxy) ethane to give ketonucleoside 6,7-dihydro-3-[[2-(p-toluoyloxy)ethoxy] methyl]imidazo[4,5-d][1,3]diazepin-8(3H)-one (9a) was followed by deprotection to 6,7-dihydro-3[(2-hydroxyethoxy)methyl]imidazo[4,5-d][1,3] diazepin-8(3H)-one (9b) and then reduction to the racemic acyclic pentostatin analogue (+/-)-3,6,7,8-tetrahydro-3-[ (2-hydroxyethoxy)methyl]imidazo[4,5-d][1,3]diazepin-8-ol (2). Ki values for the in vitro adenosine deaminase (EC 3.5.4.4; type I; calf intestinal mucosa) inhibitory activities of 1b, 1c, and 2 were determined to be 1.6 X 10(-8), 1.5 X 10(-6), and 9.8 X 10(-8) M, respectively. When compounds 2 and 9b were tested in combination with vidarabine against herpes simplex virus, type 1, in an HEp-2 plaque reduction assay, only compound 2 was able to

  19. rac-Diethyl 9-hy-droxy-9-methyl-7-phenyl-1,4-diaza-spiro-[4.5]decane-6,8-dicarboxyl-ate.

    PubMed

    Maharramov, Abel M; Ismiyev, Arif I; Rashidov, Bahruz A; Rahimova, Gunel M; Allahverdiyev, Mirza A

    2011-01-01

    The title mol-ecule, C(21)H(30)N(2)O(5), is chiral with four stereogenic centres. The crystal is a racemate and consists of enanti-omeric pairs with the relative configuration rac-(6S*,7R*,8R*,9S*). The ethyl fragment of the eth-oxy-carbonyl group at position 6 is disordered in a 0.46 (3):0.54 (3) ratio. The crystal structure features inter-molecular N-H⋯O. Intra-molecular O-H⋯N and N-H⋯O hydrogen bonds also occur. PMID:21522983

  20. Modelling the optical constants of SixGe1-x alloys in the range 1.7-5.6 eV

    NASA Astrophysics Data System (ADS)

    Djurisic, Aleksandra B.; Li, E. Herbert

    2001-02-01

    Optical constants of SixGe1-x alloys are modelled over the spectral range from 0.7 eV to 5.6 eV for all compositions 0≤x≤1. The employed model is the modified Adachi's model, which utilizes variable line broadening instead of the conventional Lorentzian one. The model takes into account transitions at the indirect band gap Egid, and critical points E0, E0 + Δ0, E1, E1 + Δ1, E0', E2(X), and E2(Σ). Excitonic effects are not considered. The model parameters are determined using a global optimization routine, namely an acceptance-probability-controlled simulated annealing algorithm. Excellent agreement with the experimental data is obtained in the entire investigated energy and composition ranges. The obtained relative root mean square errors are below 4.5% and 6.5% for the real and imaginary parts of the index of refraction, respectively.

  1. Relaxation of the V = 4,5,6,7, Sigma g/+/ vibrational levels of carbon monoxide studied by laser absorption.

    NASA Technical Reports Server (NTRS)

    Chackerian, C., Jr.; Weisbach, M. F.

    1973-01-01

    The vibrational relaxation of individual vibration rotation levels of carbon monoxide behind incident shock waves of carbon monoxide has been studied by the method of laser absorption. For the particular vibrational states (V = 4 to 7) and temperature range (2500 to 5500 K) studied, it is concluded that the characteristic relaxation times are in excellent agreement with those obtained via previous measurements of 'bulk' gas properties. Further, the data furnish strong corroboration of the idea that the individual levels are in Boltzmann vibrational equilibrium during the relaxation process.

  2. Synthesis and Application of 1,3,4,5,7,8-Hexafluorotetracyanonaphthoquinodimethane (F6-TNAP): A Conductivity Dopant for Organic Light-Emitting Devices

    SciTech Connect

    Koech, Phillip K.; Padmaperuma, Asanga B.; Wang, Liang; Swensen, James S.; Polikarpov, Evgueni; Darsell, Jens T.; Rainbolt, James E.; Gaspar, Daniel J.

    2010-07-13

    We report the synthesis, photophysical and organic light-emitting device (OLED) properties of an organic molecular p-dopant 1,3,4,5,7,8-hexafluorotetracyanonaphthoquinodimethane (F6-TNAP). F6-TNAP was obtained in a three step 2 pot synthesis from commercially available octafluoronaphthalene. Doping effect of F6-TNAP was evaluated using films of 1-5% F6-TNAP with N,N'-di-1-naphthyl-N,N'-diphenyl-1,1'-biphenyl-4,4'diamineα-NPD) co-evaporated on quartz. UV-vis analysis of these films showed an absorption peak at 950 nm corresponding to the charge transfer complex resulting from electron transfer from α-NPD to F6-TNAP. Hole only devices using α-NPD as the hole transport layer (HTL) doped with F6-TNAP show greater than 2V decrease in operating voltage compared to the undoped device. A decrease in operating voltage was also demonstrated in blue OLED devices using F6-TNAP doped HTL, with a slight decrease in external quantum efficiency (EQE), thus resulting in a net improvement in power efficiency.

  3. Ethyl 7'-(6-benz-yloxy-2,2-dimethyl-tetra-hydro-furo[3,2-d][1,3]dioxol-5-yl)-2-oxo-5',6',7',7a'-tetra-hydro-1'H,2H-spiro-[acenaphthyl-ene-1,5'-pyrrolo-[1,2-c][1,3]thia-zole]-6'-carboxyl-ate.

    PubMed

    Jagadeesan, G; Sethusankar, K; Prasanna, R; Raghunathan, R

    2012-08-01

    In the title compound, C(34)H(35)NO(7)S, the acenaphthyl-ene unit is essentially planar (r.m.s. deviation = 0.0335 Å). The pyrrolo-thia-zole ring system is folded about the bridging N-C bond; the thia-zolidine and pyrrolidine rings adopt S- and C-envelope conformations, respectively, with a 'butterfly' angle between the mean planes of 51.38 (10)°. The dioxolane and tetra-hydro-furan rings adopt O- and a C-envelope conformations, respectively, with a 'butterfly' angle between the mean planes of 57.12 (10)°. Two C atoms are each disordered over two positions with site-occupancy factors of 0.450 (7) and 0.550 (7). The crystal packing is stabilized by C-H⋯O inter-actions, generating an R(2) (2)(14) graph-set ring motif. PMID:22904945

  4. Global emission estimates and radiative impact of C4F10, C5F12, C6F14, C7F16 and C8F18

    NASA Astrophysics Data System (ADS)

    Ivy, D. J.; Rigby, M.; Baasandorj, M.; Burkholder, J. B.; Prinn, R. G.

    2012-08-01

    Global emission estimates based on new atmospheric observations are presented for the acylic high molecular weight perfluorocarbons (PFCs): decafluorobutane (C4F10), dodecafluoropentane (C5F12), tetradecafluorohexane (C6F14), hexadecafluoroheptane (C7F16) and octadecafluorooctane (C8F18). Emissions are estimated using a 3-dimensional chemical transport model and an inverse method that includes a growth constraint on emissions. The observations used in the inversion are based on newly measured archived air samples that cover a 39-yr period, from 1973 to 2011, and include 36 Northern Hemispheric and 46 Southern Hemispheric samples. The derived emission estimates show that global emission rates were largest in the 1980s and 1990s for C4F10 and C5F12, and in the 1990s for C6F14, C7F16 and C8F18. After a subsequent decline, emissions have remained relatively stable, within 20%, for the last 5 yr. Bottom-up emission estimates are available from the Emission Database for Global Atmospheric Research version 4.2 (EDGARv4.2) for C4F10, C5F12, C6F14 and C7F16, and inventories of C4F10, C5F12 and C6F14 are reported to the United Nations' Framework Convention on Climate Change (UNFCCC) by Annex 1 countries that have ratified the Kyoto Protocol. The atmospheric measurement-based emission estimates are 20 times larger than EDGARv4.2 for C4F10 and over three orders of magnitude larger for C5F12 (with 2008 EDGARv4.2 estimates for C5F12 at 9.6 kg yr-1, as compared to 67±53 t yr-1 as derived in this study). The derived emission estimates for C6F14 largely agree with the bottom-up estimates from EDGARv4.2. Moreover, the C7F16 emission estimates are comparable to those of EDGARv4.2 at their peak in the 1990s, albeit significant underestimation for the other time periods. There are no bottom-up emission estimates for C8F18, thus the emission rates reported here are the first for C8F18. The reported inventories for C4F10, C5F12 and C6F14 to UNFCCC are five to ten times lower than those

  5. Cox Decompression Manipulation and Guided Rehabilitation of a Patient With a Post Surgical C6-C7 Fusion With Spondylotic Myelopathy and Concurrent L5-S1 Radiculopathy

    PubMed Central

    Joachim, George C.

    2014-01-01

    Objective The purpose of this case report is to describe combined treatment utilizing Cox distraction manipulation and guided rehabilitation for a patient with spine pain and post-surgical C6-7 fusion with spondylotic myelopathy and L5-S1 radiculopathy. Clinical features A 38-year-old man presented to a chiropractic clinic with neck pain and a history of an anterior cervical spine plate fusion at C6-7 after a work related accident 4 years earlier. He had signs and symptoms of spondolytic myelopathy and right lower back, right posterior thigh pain and numbness. Intervention and outcome The patient was treated with Cox technique and rehabilitation. The patient experienced a reduction of pain on a numeric pain scale from 8/10 to 3/10. The patient was seen a total of 12 visits over 3 months. No adverse effects were reported. Conclusions A patient with a prior C6-7 fusion with spondylotic myelopathy and concurrent L5-S1 radiculopathy improved after a course of rehabilitation and Cox distraction manipulation. Further research is needed to establish its efficiency. PMID:25685119

  6. Ultrafast response of plasmalike reflectivity edge in (TMTTF) 2As F6 driven by a 7-fs 1.5-cycle strong-light field

    NASA Astrophysics Data System (ADS)

    Naitoh, Y.; Kawakami, Y.; Ishikawa, T.; Sagae, Y.; Itoh, H.; Yamamoto, K.; Sasaki, T.; Dressel, M.; Ishihara, S.; Tanaka, Y.; Yonemitsu, K.; Iwai, S.

    2016-04-01

    The strong-light field effect of (TMTTF) 2As F6 was investigated utilizing 1.5-cycle, 7-fs infrared pulses. The ultrafast (˜20 fs ) and large (˜40 %) response of the plasmalike reflectivity edge (˜0.7 eV ) was analyzed by the changes in ωp=√{n e2/(ɛ∞ɛ0m ) } (n : number of charges in the frac14- filled band; m : mass of charge; ɛ∞,ɛ0 : dielectric constants for high frequency and vacuum; e : elementary charge). The 3% reduction in ωp is attributed to the 6% increase in m . Furthermore, 20 fs oscillation of ωp in the time domain indicates that the plasmalike edge is affected by the charge gap (˜0.2 eV ) nature. Theoretical calculations suggest that the Coulomb repulsion plays an important role in the increase in m .

  7. Rupture processes of the 2012 September 5 Mw 7.6 Nicoya, Costa Rica earthquake constrained by improved geodetic and seismological observations

    NASA Astrophysics Data System (ADS)

    Liu, Chengli; Zheng, Yong; Xiong, Xiong; Wang, Rongjiang; López, Allan; Li, Jun

    2015-10-01

    On 2012 September 5, the anticipated interplate thrust earthquake ruptured beneath the Nicoya peninsula in northwestern Costa Rica close to the Middle America trench, with a magnitude Mw 7.6. Extensive co-seismic observations were provided by dense near-field strong ground motion, Global Positioning Systems (GPS) networks and teleseismic recordings from global seismic networks. The wealthy data sets available for the 2012 Mw 7.6 Nicoya earthquake provide a unique opportunity to investigate the details of the rupture process of this earthquake. By implementing a non-linear joint inversion with high-rate GPS waveform, more static GPS offsets, strong-motion data and teleseismic body waveform, we obtained a robust and accurate rupture model of the 2012 Mw 7.6 Nicoya earthquake. The earthquake is dominantly a pure thrust component with a maximum slip of 3.5 m, and the main large slip patch is located below the hypocentre, spanning ˜50 km along dip and ˜110 km along strike. The static stress drop is about 3.4 MPa. The total seismic moment of our preferred model is 3.46 × 1020 N m, which gives Mw = 7.6. Due to the fast rupture velocity, most of the seismic moment was released within 70 s. The largest slip patch directly overlaps the interseismic locked region identified by geodetic observations and extends downdip to the intersection with the upper plate Moho. We also find that there is a complementary pattern between the distribution of aftershocks and the co-seismic rupture; most aftershocks locate in the crust of the upper plate and are possibly induced by the stress change caused by the large slip patch.

  8. Sterol biosynthesis: strong inhibition of maize delta 5,7-sterol delta 7-reductase by novel 6-aza-B-homosteroids and other analogs of a presumptive carbocationic intermediate of the reduction reaction.

    PubMed

    Rahier, A; Taton, M

    1996-06-01

    A series of mono- and diazasteroids have been synthesized as analogs of a predicted carbocationic intermediate of delta 5,7-sterol delta 7-reductase (delta 7-SR). 6-Aza-B-homo-5 alpha-cholest-7-en-3 beta-ol (4), a novel compound whose synthesis is described for the first time, and 6,7-diaza-5 alpha-cholest-8(14)-en-3 beta-ol (6) were shown to be very powerful inhibitors of delta 7-SR in a preparation isolated from maize (Zea mays) (K(i),app = 50-70 nM, Ki,app/Km,app = 1.0 x 10(-4) to 1.3 x 10(-4). The data are consistent with a carbonium ion mechanism for the reduction; compounds 4 and 6 probably act as reaction intermediate analogs. Compound 4, in contrast to compound 6, displayed in the same microsomal preparation more than 50-fold selectivity for inhibition of the delta 7-SR versus delta 8-delta 7-sterol isomerase, cycloeucalenol isomerase, and delta 8,14-sterol delta 14-reductase, the mechanism of these four enzymes involving presumptive cationic intermediates centered respectively at C7, C8, C9, and C14. These observations highlight the paramount importance of the location of the positively charged nitrogen atom(s) in the B-ring structure for selectivity among these enzymes involving structurally close cationic reaction intermediates. Efficient in vivo inhibition of sterol biosynthesis in bramble cell suspension cultures by a low concentration of compound 4 was demonstrated and confirmed the in vitro properties of this derivative.) PMID:8679532

  9. Global emission estimates and radiative impact of C4F10, C5F12, C6F14, C7F16 and C8F18

    NASA Astrophysics Data System (ADS)

    Ivy, D. J.; Rigby, M.; Baasandorj, M.; Burkholder, J. B.; Prinn, R. G.

    2012-05-01

    Global emission estimates based on new atmospheric observations are presented for the acylic high molecular weight perfluorocarbons (PFCs): decafluorobutane (C4F10), dodecafluoropentane (C5F12), tetradecafluorohexane (C6F14), hexadecafluoroheptane (C7F16) and octadecafluorooctane (C8F18). Emissions are estimated using a 3-dimensional chemical transport model and an inverse method that includes a growth constraint on emissions. The observations used in the inversion are based on newly measured archived air samples that cover a 39-yr period, from 1973 to 2011, and include 36 Northern Hemispheric and 46 Southern Hemispheric samples (Ivy et al., 2012). The derived emission estimates show that global emission rates were largest in the 1980s and 1990s for C4F10 and C5F12, and in the 1990s for C6F14,C7F16 and C8F18. After a subsequent decline, emissions have remained relatively stable, within 20%, for the last 5 yr. Bottom-up emission estimates are available from the Emission Database for Global Atmospheric Research version 4.2 (EDGARv4.2) for C4F10, C5F12, C6F14 and C7F16, and inventories of C4F10, C5F12 andC6F14 are reported to the United Nations' Framework Convention on Climate Change (UNFCCC) by Annex 1 countries that have ratified the Kyoto Protocol. The atmospheric measurement based emission estimates are 20 times larger than EDGARv4.2 for C4F10 and over three orders of magnitude for C5F12. The derived emission estimates for C6F14 largely agree with the bottom-up estimates from EDGARv4.2. Moreover, the C7F16 emission estimates are comparable to those of EDGARv4.2 at their peak in the 1990s, albeit significant underestimation for the other time periods. There are no bottom-up emission estimates for C8F18, thus the emission rates reported here are the first for C8F18. The reported inventories for C4F10, C5F12 and C6F14 to UNFCCC are five to ten times lower than those estimated in this study. In addition, we present measured infrared absorption spectra for C7F16 and C8

  10. 3.6 and 4.5 μm Spitzer Phase Curves of the Highly Irradiated Hot Jupiters WASP-19b and HAT-P-7b

    NASA Astrophysics Data System (ADS)

    Wong, Ian; Knutson, Heather A.; Kataria, Tiffany; Lewis, Nikole K.; Burrows, Adam; Fortney, Jonathan J.; Schwartz, Joel; Shporer, Avi; Agol, Eric; Cowan, Nicolas B.; Deming, Drake; Désert, Jean-Michel; Fulton, Benjamin J.; Howard, Andrew W.; Langton, Jonathan; Laughlin, Gregory; Showman, Adam P.; Todorov, Kamen

    2016-06-01

    We analyze full-orbit phase curve observations of the transiting hot Jupiters WASP-19b and HAT-P-7b at 3.6 and 4.5 μm, obtained using the Spitzer Space Telescope. For WASP-19b, we measure secondary eclipse depths of 0.485%+/- 0.024% and 0.584%+/- 0.029% at 3.6 and 4.5 μm, which are consistent with a single blackbody with effective temperature 2372 ± 60 K. The measured 3.6 and 4.5 μm secondary eclipse depths for HAT-P-7b are 0.156%+/- 0.009% and 0.190%+/- 0.006%, which are well described by a single blackbody with effective temperature 2667 ± 57 K. Comparing the phase curves to the predictions of one-dimensional and three-dimensional atmospheric models, we find that WASP-19b’s dayside emission is consistent with a model atmosphere with no dayside thermal inversion and moderately efficient day–night circulation. We also detect an eastward-shifted hotspot, which suggests the presence of a superrotating equatorial jet. In contrast, HAT-P-7b’s dayside emission suggests a dayside thermal inversion and relatively inefficient day–night circulation; no hotspot shift is detected. For both planets, these same models do not agree with the measured nightside emission. The discrepancies in the model-data comparisons for WASP-19b might be explained by high-altitude silicate clouds on the nightside and/or high atmospheric metallicity, while the very low 3.6 μm nightside planetary brightness for HAT-P-7b may be indicative of an enhanced global C/O ratio. We compute Bond albedos of 0.38 ± 0.06 and 0 (\\lt 0.08 at 1σ ) for WASP-19b and HAT-P-7b, respectively. In the context of other planets with thermal phase curve measurements, we show that WASP-19b and HAT-P-7b fit the general trend of decreasing day–night heat recirculation with increasing irradiation.

  11. Hydrido copper clusters supported by dithiocarbamates: oxidative hydride removal and neutron diffraction analysis of [Cu7(H){S2C(aza-15-crown-5)}6].

    PubMed

    Liao, Ping-Kuei; Fang, Ching-Shiang; Edwards, Alison J; Kahlal, Samia; Saillard, Jean-Yves; Liu, C W

    2012-06-18

    Reactions of Cu(I) salts with Na(S(2)CR) (R = N(n)Pr(2), NEt(2), aza-15-crown-5), and (Bu(4)N)(BH(4)) in an 8:6:1 ratio in CH(3)CN solution at room temperature yield the monocationic hydride-centered octanuclear Cu(I) clusters, [Cu(8)(H){S(2)CR}(6)](PF(6)) (R = N(n)Pr(2), 1(H); NEt(2), 2(H); aza-15-crown-5, 3(H)). Further reactions of [Cu(8)(H){S(2)CR}(6)](PF(6)) with 1 equiv of (Bu(4)N)(BH(4)) produced neutral heptanuclear copper clusters, [Cu(7)(H){S(2)CR}(6)] (R = N(n)Pr(2), 4(H); NEt(2), 5(H); aza-15-crown-5, 6(H)) and clusters 4-6 can also be generated from the reaction of Cu(BF(4))(2), Na(S(2)CR), and (Bu(4)N)(BH(4)) in a 7:6:8 molar ratio in CH(3)CN. Reformation of cationic Cu(I)(8) clusters by adding 1 equiv of Cu(I) salt to the neutral Cu(7) clusters in solution is observed. Intriguingly, the central hydride in [Cu(8)(H){S(2)CN(n)Pr(2)}(6)](PF(6)) can be oxidatively removed as H(2) by Ce(NO(3))(6)(2-) to yield [Cu(II)(S(2)CN(n)Pr(2))(2)] exploiting the redox-tolerant nature of dithiocarbamates. Regeneration of hydride-centered octanuclear copper clusters from the [Cu(II)(S(2)CN(n)Pr(2))(2)] can be achieved by reaction with Cu(I) ions and borohydride. The hydride release and regeneration of Cu(I)(8) was monitored by UV-visible titration experiments. To our knowledge, this is the first time that hydride encapsulated within a copper cluster can be released as H(2) via chemical means. All complexes have been fully characterized by (1)H NMR, FT-IR, UV-vis, and elemental analysis, and molecular structures of 1(H), 2(H), and 6(H) were clearly established by single-crystal X-ray diffraction. Both 1(H) and 2(H) exhibit a tetracapped tetrahedral Cu(8) skeleton, which is inscribed within a S(12) icosahedron constituted by six dialkyl dithiocarbamate ligands in a tetrametallic-tetraconnective (μ(2), μ(2)) bonding mode. The copper framework of 6(H) is a tricapped distorted tetrahedron in which the four-coordinate hydride is demonstrated to occupy the central site by

  12. The Inhibitory Mechanisms Study of 5,6,4'-Trihydroxy-7,3'-Dimethoxyflavone against the LPS-Induced Macrophage Inflammatory Responses through the Antioxidant Ability.

    PubMed

    Wang, Shih-Hao; Liang, Chia-Hua; Liang, Fong-Pin; Ding, Hsiou-Yu; Lin, Shiuan-Pey; Huang, Guan-Jhong; Lin, Wen-Chuan; Juang, Shin-Hun

    2016-01-01

    The whole plant of Anisomeles ovata has been widely used in Taiwan for treating inflammation-related skin and liver diseases, however, the detailed pharmacology mechanisms have yet to be elucidated. In the present study, one of the major components, 5,6,4'-trihydroxy-7,3'-dimethoxyflavone (5-TDMF), was purified from a methanol extract of Anisomeles ovata. A pharmacological study of this compound suggests that 5-TDMF possesses potent free radical scavenging activity both in vitro and ex vivo. Furthermore, 5-TDMF reduces nitric oxide and pro-inflammatory cytokine production in LPC-treated RAW 264.7 cells through the attenuation of nitric oxide synthase and cyclooxygenase-2. Additional experiments suggest that of 5-TDMF interferes with nuclear factor-κB translocation and mitogen-activated protein kinase pathways. These results identify 5-TDMF as an anti-oxidant and anti-inflammatory compound, explain the pharmacologic function of Anisomeles ovata and suggest its great potential as a new anti-inflammatory remedy. PMID:26805809

  13. Superconducting fiber with transition temperature up to 7.43 K in Nb2PdxS5-δ (0.6 < x <1).

    PubMed

    Yu, Hongyan; Zuo, Ming; Zhang, Lei; Tan, Shun; Zhang, Changjin; Zhang, Yuheng

    2013-09-01

    Wiring systems powered by highly efficient superconductors have long been a dream of scientists, but researchers have faced practical challenges such as finding flexible materials. Here we report superconductivity in Nb2PdxS5-δ fibers with transition temperature up to 7.43 K, which have typical diameters of 0.3-3 μm. Superconductivity occurs in a wide range of Pd (0.6 < x <1) and S (0 < δ <0.61) contents, suggesting that the superconductivity in this system is very robust. Long fibers with suitable size provide a new route to high-power transmission cables and electronic devices. PMID:23964660

  14. 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidines as novel class of potent and highly selective CaMKII inhibitors.

    PubMed

    Asano, Shigehiro; Komiya, Masafumi; Koike, Nobuyuki; Koga, Erina; Nakatani, Shogo; Isobe, Yoshiaki

    2010-11-15

    A novel series of 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidines containing substituted phenyl sulfonamide are synthesized and evaluated for their inhibitory activity against CaMKII. Substituents on the phenyl group had significant impact on CaMKII inhibition, in particular, the inhibitory activity of 8p was 25-fold higher than that of KN-93, a known CaMKII inhibitor. Michaelis-Menten analysis of a representative compound suggested that the synthesized pyrimidines are calmodulin non-competitive inhibitors. Finally, 8p exhibited more than 100-fold higher selectivity for CaMKII over five types of off-target kinases. PMID:20875738

  15. 3,5,6,7,8,3',4'-Heptamethoxyflavone, a citrus flavonoid, on protection against memory impairment and neuronal cell death in a global cerebral ischemia mouse model.

    PubMed

    Okuyama, Satoshi; Morita, Mayu; Miyoshi, Kazuhiro; Nishigawa, Yuki; Kaji, Miki; Sawamoto, Atsushi; Terugo, Tsukasa; Toyoda, Nobuki; Makihata, Nahomi; Amakura, Yoshiaki; Yoshimura, Morio; Nakajima, Mitsunari; Furukawa, Yoshiko

    2014-05-01

    The present study evaluated the effects of treatment with the citrus flavonoid, 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF) on protection against memory impairment and neuronal death in a global cerebral ischemia mouse model. The results showed that HMF, administrated for three days immediately after ischemic surgery, protected against ischemia-induced memory dysfunction, rescued neuronal cell death in the CA1 cell layer, increased the production of BDNF, stimulated the autophosphorylation of CaMK II and suppressed microglial activation in the hippocampus. These results suggest that HMF has a neuroprotective effect after brain ischemia by inducing BDNF production and anti-inflammatory effects. PMID:24657445

  16. Facile synthesis of 4,5,6a,7-tetrahydrodibenzo[de,g]chromene heterocycles and their transformation to phenanthrene alkaloids

    PubMed Central

    Kapadia, Nirav; Harding, Wayne

    2013-01-01

    Oxa-Pictet-Spengler cyclization and microwave-assisted C-H arylation have been implemented as key steps in the synthesis of new isochroman heterocycles containing a 4,5,6a,7-tetrahydrodibenzo[de,g]chromene motif. These isochromans may be easily transformed to phenanthrene alkaloids via acidic cleavage of the isochroman ring and standard synthetic manipulations thereafter. The route described is attractive in that it provides access to two biologically interesting scaffolds in simple and high yielding synthetic steps. PMID:24187388

  17. Coherence properties of a 2.6-7.5  μm frequency comb produced as a subharmonic of a Tm-fiber laser.

    PubMed

    Smolski, V O; Yang, H; Gorelov, S D; Schunemann, P G; Vodopyanov, K L

    2016-04-01

    We study the temporal coherence of an ultrabroadband frequency comb produced in a degenerate GaAs optical parametric oscillator (OPO) pumped by a stabilized Tm-fiber comb, by observing multiheterodyne beats in the RF domain. We infer that in such a regime the OPO automatically produces a stable frequency comb that is phase and frequency locked to the pump. By varying intracavity dispersion, we achieve a comb spanning 2.6-7.5 μm at a -20  dB level. Low pump threshold (down to 7 mW), high average power (up to 73 mW), broad spectral coverage, flat spectrum, and high coherence make this comb a source suitable for various applications, foremost dual-comb molecular spectroscopy. PMID:27192243

  18. 2-Amino-4-(4-meth-oxy-phen-yl)-7,7-di-methyl-5-oxo-5,6,7,8-tetra-hydro-4H-chromene-3-carbonitrile propan-2-one monosolvate.

    PubMed

    Mohamed, Shaaban K; Akkurt, Mehmet; Tahir, Muhammad N; Abdelhamid, Antar A; Allahverdiyev, M A

    2012-07-01

    In the crystal structure of the title compound, C(19)H(20)N(2)O(3)·C(3)H(6)O, mol-ecules are linked into inversion dimers with an R(2) (2)(12) motif by pairs of N-H⋯N hydrogen bonds. These dimers are further connected into chains running along the a axis by N-H⋯O hydrogen bonds. C-H⋯N and C-H⋯π inter-actions also feature in the packing. The cyclohexene ring adopts nearly an envelope conformation [puckering parameters are Q(T) = 0.456 (2) Å, θ = 54.6 (3)° and ϕ = 225.2 (3)°]. PMID:22798868

  19. Laser action from 1,3,5,7-tetramethyl-2,6-diethyl-8-n-propyl pyrromethene-BF2

    NASA Astrophysics Data System (ADS)

    Zeng, Heping; Liang, Feng; Sun, Zhenrong; Yuan, Yizhong; Yao, Zuguang; Xu, Zhizhan

    2002-06-01

    We measured spectroscopic and laser action properties of a novel 8-position substituted pyrromethene-BF2, namely 1,3,5,7-tetramethyl-2,6-diethyl-8-n-propyl pyrromethene-BF2 complex. The laser action was performed with the corresponding dye solution in ethanol, which was placed in a Littman-type laser cavity pumped by the second harmonic of a Q-switched Nd:YAG laser. The spectroscopic measurements clearly indicated that the corresponding dye solution in ethanol exhibited intense absorption in the visible spectral region with large fluorescence quantum yield. It possesses rather low triplet-triplet absorption in the spectral region 460-550 nm and almost negligible triplet-triplet absorption in the lasing spectral region. As a consequence, it lases nearly as efficiently as commercially available benchmark laser dyes such as Rhodamine-6G and outperformed them in wavelength tunability in our laser cavity and pump geometry.

  20. Monte Carlo N–Particle Transport Code System Including MCNP6.1, MCNP5-1.60, MCNPX-2.7.0 and Data Libraries.

    2013-07-16

    Version 01 US DOE 10CFR810 Jurisdiction. MCNP6™ is a general-purpose, continuous-energy, generalized-geometry, time-dependent, Monte Carlo radiation-transport code designed to track many particle types over broad ranges of energies. MCNP6 represents the culmination of a multi-year effort to merge the MCNP5™ [X-503] and MCNPX™ [PEL11] codes into a single product comprising all features of both. For those familiar with previous versions of MCNP, you will discover the code has been expanded to handle a multitude ofmore » particles and to include model physics options for energies above the cross-section table range, a material burnup feature, and delayed particle production. Expanded and/or new tally, source, and variance-reduction options are available to the user as well as an improved plotting capability. The capability to calculate keff eigenvalues for fissile systems remains a standard feature. Although MCNP6 is simply and accurately described as the merger of MCNP5 and MCNPX capabilities, the result is much more than the sum of these two computer codes. MCNP6 is the result of five years of effort by the MCNP5 and MCNPX code development teams. These groups of people, residing in the Los Alamos National Laboratory's (LANL) X Computational Physics Division, Monte Carlo Codes Group (XCP-3), and Nuclear Engineering and Nonproliferation Division, Systems Design and Analysis Group (NEN-5, formerly D-5), have combined their code development efforts to produce the next evolution of MCNP. While maintenance and bug fixes will continue for MCNP5 v.1.60 and MCNPX v.2.7.0 for upcoming years, new code development capabilities will be developed and released only in MCNP6. In fact, this initial production release of MCNP6 (v. 1.0) contains 16 new features not previously found in either code. These new features include (among others) the abilities to import unstructured mesh geometries from the finite element code Abaqus, to transport photons down to 1.0 eV, to model

  1. Monte Carlo N–Particle Transport Code System Including MCNP6.1, MCNP5-1.60, MCNPX-2.7.0 and Data Libraries.

    2013-07-16

    Version 00 US DOE 10CFR810 Jurisdiction. MCNP6™ is a general-purpose, continuous-energy, generalized-geometry, time-dependent, Monte Carlo radiation-transport code designed to track many particle types over broad ranges of energies. MCNP6 represents the culmination of a multi-year effort to merge the MCNP5™ [X-503] and MCNPX™ [PEL11] codes into a single product comprising all features of both. For those familiar with previous versions of MCNP, you will discover the code has been expanded to handle a multitude ofmore » particles and to include model physics options for energies above the cross-section table range, a material burnup feature, and delayed particle production. Expanded and/or new tally, source, and variance-reduction options are available to the user as well as an improved plotting capability. The capability to calculate keff eigenvalues for fissile systems remains a standard feature. Although MCNP6 is simply and accurately described as the merger of MCNP5 and MCNPX capabilities, the result is much more than the sum of these two computer codes. MCNP6 is the result of five years of effort by the MCNP5 and MCNPX code development teams. These groups of people, residing in the Los Alamos National Laboratory's (LANL) X Computational Physics Division, Monte Carlo Codes Group (XCP-3), and Nuclear Engineering and Nonproliferation Division, Systems Design and Analysis Group (NEN-5, formerly D-5), have combined their code development efforts to produce the next evolution of MCNP. While maintenance and bug fixes will continue for MCNP5 v.1.60 and MCNPX v.2.7.0 for upcoming years, new code development capabilities will be developed and released only in MCNP6. In fact, this initial production release of MCNP6 (v. 1.0) contains 16 new features not previously found in either code. These new features include (among others) the abilities to import unstructured mesh geometries from the finite element code Abaqus, to transport photons down to 1.0 eV, to model

  2. Monte Carlo N–Particle Transport Code System Including MCNP6.1, MCNP5-1.60, MCNPX-2.7.0 and Data Libraries.

    SciTech Connect

    GOORLEY, TIM

    2013-07-16

    Version 00 US DOE 10CFR810 Jurisdiction. MCNP6™ is a general-purpose, continuous-energy, generalized-geometry, time-dependent, Monte Carlo radiation-transport code designed to track many particle types over broad ranges of energies. MCNP6 represents the culmination of a multi-year effort to merge the MCNP5™ [X-503] and MCNPX™ [PEL11] codes into a single product comprising all features of both. For those familiar with previous versions of MCNP, you will discover the code has been expanded to handle a multitude of particles and to include model physics options for energies above the cross-section table range, a material burnup feature, and delayed particle production. Expanded and/or new tally, source, and variance-reduction options are available to the user as well as an improved plotting capability. The capability to calculate keff eigenvalues for fissile systems remains a standard feature. Although MCNP6 is simply and accurately described as the merger of MCNP5 and MCNPX capabilities, the result is much more than the sum of these two computer codes. MCNP6 is the result of five years of effort by the MCNP5 and MCNPX code development teams. These groups of people, residing in the Los Alamos National Laboratory's (LANL) X Computational Physics Division, Monte Carlo Codes Group (XCP-3), and Nuclear Engineering and Nonproliferation Division, Systems Design and Analysis Group (NEN-5, formerly D-5), have combined their code development efforts to produce the next evolution of MCNP. While maintenance and bug fixes will continue for MCNP5 v.1.60 and MCNPX v.2.7.0 for upcoming years, new code development capabilities will be developed and released only in MCNP6. In fact, this initial production release of MCNP6 (v. 1.0) contains 16 new features not previously found in either code. These new features include (among others) the abilities to import unstructured mesh geometries from the finite element code Abaqus, to transport photons down to 1.0 eV, to model complete atomic

  3. Monte Carlo N–Particle Transport Code System Including MCNP6.1, MCNP5-1.60, MCNPX-2.7.0 and Data Libraries.

    SciTech Connect

    GOORLEY, TIM

    2013-07-16

    Version 01 US DOE 10CFR810 Jurisdiction. MCNP6™ is a general-purpose, continuous-energy, generalized-geometry, time-dependent, Monte Carlo radiation-transport code designed to track many particle types over broad ranges of energies. MCNP6 represents the culmination of a multi-year effort to merge the MCNP5™ [X-503] and MCNPX™ [PEL11] codes into a single product comprising all features of both. For those familiar with previous versions of MCNP, you will discover the code has been expanded to handle a multitude of particles and to include model physics options for energies above the cross-section table range, a material burnup feature, and delayed particle production. Expanded and/or new tally, source, and variance-reduction options are available to the user as well as an improved plotting capability. The capability to calculate keff eigenvalues for fissile systems remains a standard feature. Although MCNP6 is simply and accurately described as the merger of MCNP5 and MCNPX capabilities, the result is much more than the sum of these two computer codes. MCNP6 is the result of five years of effort by the MCNP5 and MCNPX code development teams. These groups of people, residing in the Los Alamos National Laboratory's (LANL) X Computational Physics Division, Monte Carlo Codes Group (XCP-3), and Nuclear Engineering and Nonproliferation Division, Systems Design and Analysis Group (NEN-5, formerly D-5), have combined their code development efforts to produce the next evolution of MCNP. While maintenance and bug fixes will continue for MCNP5 v.1.60 and MCNPX v.2.7.0 for upcoming years, new code development capabilities will be developed and released only in MCNP6. In fact, this initial production release of MCNP6 (v. 1.0) contains 16 new features not previously found in either code. These new features include (among others) the abilities to import unstructured mesh geometries from the finite element code Abaqus, to transport photons down to 1.0 eV, to model complete atomic

  4. TOXIC SUBSTANCES FROM COAL COMBUSTION--A COMPREHENSIVE ASSESSMENT, PHASE II: ELEMENT MODES OF OCCURRENCE FOR THE OHIO 5/6/7, WYODAK AND NORTH DAKOTA COAL SAMPLES

    SciTech Connect

    Allan Kolker; Stanley J. Mroczkowski; Curtis A. Palmer; Kristen O. Dennen; Robert B. Finkelman; John H. Bullock Jr.

    2002-05-30

    This study reports on the second phase (Phase II) of USGS research activities in support of DOE contract DE-AC22-95PC95101 ''Toxic Substances From Coal Combustion--A Comprehensive Assessment'', funded under DOE Interagency Agreement DE-AI22-95PC95145. The purpose of the study was to provide a quantitative and semi-quantitative characterization of the modes of occurrence of trace elements in coal samples investigated under Phase II, including (1) Ohio 5/6/7, an Ohio bituminous coal sample blended from the No.5, No.6, and No.7 beds; (2) North Dakota, a lignite sample from the Falkirk Mine, Underwood, ND, and (3) Wyodak, a sub-bituminous coal sample from the Cordero Mine, Gillette, WY. Samples from these coal beds were selected for their range in rank and commercial applicability. Results of this research provide basic information on the distribution of elements in Phase II coal samples, information needed for development of a commercial predictive model for trace-element behavior during coal combustion.

  5. PIP2-dependent coupling is prominent in Kv7.1 due to weakened interactions between S4-S5 and S6

    NASA Astrophysics Data System (ADS)

    Kasimova, Marina A.; Zaydman, Mark A.; Cui, Jianmin; Tarek, Mounir

    2015-01-01

    Among critical aspects of voltage-gated potassium (Kv) channels' functioning is the effective communication between their two composing domains, the voltage sensor (VSD) and the pore. This communication, called coupling, might be transmitted directly through interactions between these domains and, as recently proposed, indirectly through interactions with phosphatidylinositol-4,5-bisphosphate (PIP2), a minor lipid of the inner plasma membrane leaflet. Here, we show how the two components of coupling, mediated by protein-protein or protein-lipid interactions, both contribute in the Kv7.1 functioning. On the one hand, using molecular dynamics simulations, we identified a Kv7.1 PIP2 binding site that involves residues playing a key role in PIP2-dependent coupling. On the other hand, combined theoretical and experimental approaches have shown that the direct interaction between the segments of the VSD (S4-S5) and the pore (S6) is weakened by electrostatic repulsion. Finally, we conclude that due to weakened protein-protein interactions, the PIP2-dependent coupling is especially prominent in Kv7.1.

  6. PIP₂-dependent coupling is prominent in Kv7.1 due to weakened interactions between S4-S5 and S6.

    PubMed

    Kasimova, Marina A; Zaydman, Mark A; Cui, Jianmin; Tarek, Mounir

    2015-01-01

    Among critical aspects of voltage-gated potassium (Kv) channels' functioning is the effective communication between their two composing domains, the voltage sensor (VSD) and the pore. This communication, called coupling, might be transmitted directly through interactions between these domains and, as recently proposed, indirectly through interactions with phosphatidylinositol-4,5-bisphosphate (PIP₂), a minor lipid of the inner plasma membrane leaflet. Here, we show how the two components of coupling, mediated by protein-protein or protein-lipid interactions, both contribute in the Kv7.1 functioning. On the one hand, using molecular dynamics simulations, we identified a Kv7.1 PIP₂ binding site that involves residues playing a key role in PIP₂-dependent coupling. On the other hand, combined theoretical and experimental approaches have shown that the direct interaction between the segments of the VSD (S4-S5) and the pore (S6) is weakened by electrostatic repulsion. Finally, we conclude that due to weakened protein-protein interactions, the PIP2-dependent coupling is especially prominent in Kv7.1. PMID:25559286

  7. PIP2-dependent coupling is prominent in Kv7.1 due to weakened interactions between S4-S5 and S6

    PubMed Central

    Kasimova, Marina A.; Zaydman, Mark A.; Cui, Jianmin; Tarek, Mounir

    2015-01-01

    Among critical aspects of voltage-gated potassium (Kv) channels' functioning is the effective communication between their two composing domains, the voltage sensor (VSD) and the pore. This communication, called coupling, might be transmitted directly through interactions between these domains and, as recently proposed, indirectly through interactions with phosphatidylinositol-4,5-bisphosphate (PIP2), a minor lipid of the inner plasma membrane leaflet. Here, we show how the two components of coupling, mediated by protein-protein or protein-lipid interactions, both contribute in the Kv7.1 functioning. On the one hand, using molecular dynamics simulations, we identified a Kv7.1 PIP2 binding site that involves residues playing a key role in PIP2-dependent coupling. On the other hand, combined theoretical and experimental approaches have shown that the direct interaction between the segments of the VSD (S4–S5) and the pore (S6) is weakened by electrostatic repulsion. Finally, we conclude that due to weakened protein-protein interactions, the PIP2-dependent coupling is especially prominent in Kv7.1. PMID:25559286

  8. Evaluation of plasma cholestane-3β,5α,6β-triol and 7-ketocholesterol in inherited disorders related to cholesterol metabolism.

    PubMed

    Boenzi, Sara; Deodato, Federica; Taurisano, Roberta; Goffredo, Bianca Maria; Rizzo, Cristiano; Dionisi-Vici, Carlo

    2016-03-01

    Oxysterols are intermediates of cholesterol metabolism and are generated from cholesterol via either enzymatic or nonenzymatic pathways under oxidative stress conditions. Cholestan-3β,5α,6β-triol (C-triol) and 7-ketocholesterol (7-KC) have been proposed as new biomarkers for the diagnosis of Niemann-Pick type C (NP-C) disease, representing an alternative tool to the invasive and time-consuming method of fibroblast filipin test. To test the efficacy of plasma oxysterol determination for the diagnosis of NP-C, we systematically screened oxysterol levels in patients affected by different inherited disorders related with cholesterol metabolism, which included Niemann-Pick type B (NP-B) disease, lysosomal acid lipase (LAL) deficiency, Smith-Lemli-Opitz syndrome (SLOS), congenital familial hypercholesterolemia (FH), and sitosterolemia (SITO). As expected, NP-C patients showed significant increase of both C-triol and 7-KC. Strong increase of both oxysterols was observed in NP-B and less pronounced in LAL deficiency. In SLOS, only 7-KC was markedly increased, whereas in both FH and in SITO, oxysterol concentrations were normal. Interestingly, in NP-C alone, we observed that plasma oxysterols correlate negatively with patient's age and positively with serum total bilirubin, suggesting the potential relationship between oxysterol levels and hepatic disease status. Our results indicate that oxysterols are reliable and sensitive biomarkers of NP-C. PMID:26733147

  9. Formation and characterization of microstructure of as-cast Mg–6Gd–4Y–xZn–0.5Zr (x = 0.3, 0.5 and 0.7 wt.%) alloys

    SciTech Connect

    Wu, Y.J.; Xu, C.; Zheng, F.Y.; Peng, L.M.; Zhang, Y.; Ding, W.J.

    2013-05-15

    Mg–6Gd–4Y–xZn–0.5Zr (x = 0.3, 0.5 and 0.7 wt.%) alloys were prepared via conventional ingot metallurgy (I/M) in this study. The as-cast microstructures of these alloys were established by X-ray diffraction (XRD) analyses, optical microscope (OM), scanning electron microscope (SEM) and transmission electron microscope (TEM) observations. Lamellar stacking order (SF) and 14H-type long period stacking order (LPSO) structure within α-Mg matrix are formed in the three as-cast alloys. The eutectic secondary phase is (Mg,Zn){sub 24}(Gd,Y){sub 5} for the alloy containing 0.3 wt.% Zn, while, it is (Mg,Zn){sub 3}(Gd,Y) for the alloys containing 0.5 wt.% Zn and 0.7 wt.% Zn. Moreover, X phase-(Mg,Zn){sub 12}(Gd,Y) is formed in the latter two as-cast alloys. - Highlights: • LPSO structure has first been found in as-cast Mg–6Gd–4Y–xZn–0.5Zr. • X-phase exists in as-cast Mg–6Gd–4Y–0.3(0.5)Zn–0.5Zr. • Zn content results in different β-phase in the studied alloys.

  10. Tropical glacier fluctuations in the Cordillera Blanca, Peru between 12.5 and 7.6 ka from cosmogenic 10Be dating

    NASA Astrophysics Data System (ADS)

    Glasser, Neil F.; Clemmens, Samuel; Schnabel, Christoph; Fenton, Cassandra R.; McHargue, Lanny

    2009-12-01

    We report cosmogenic surface exposure 10Be ages of 21 boulders on moraines in the Jeullesh and Tuco Valleys, Cordillera Blanca, Peru (˜10°S at altitudes above 4200 m). Ages are based on the sea-level at high-latitude reference production rate and scaling system of Lifton et al. (2005. Addressing solar modulation and long-term uncertainties in scaling secondary cosmic rays for in situ cosmogenic nuclide applications. Earth and Planetary Science Letters 239, 140-161) in the CRONUS-Earth online calculator of Balco et al. (2008. A complete and easily accessible means of calculating surface exposure ages or erosion rates from 10Be and 26Al measurements. Quaternary Geochronology 3, 174-195). Using the Lifton system, large outer lateral moraines in the Jeullesh Valley have a 10Be exposure age of 12.4 ka, inside of which are smaller moraine systems dated to 10.8, 9.7 and 7.6 ka. Large outer lateral moraines in the Tuco Valley have a 10Be exposure age of 12.5 ka, with inner moraines dated to 11.3 and 10.7 ka. Collectively, these data indicate that glacier recession from the Last Glacial Maximum (LGM) in the Cordillera Blanca was punctuated by three to four stillstands or minor advances during the period 12.5-7.6 ka, spanning the Younger Dryas Chronozone (YDC; ˜12.9-11.6 ka) and the cold event identified in Greenland ice cores and many other parts of the world at 8.2 ka. The inferred fluctuations of tropical glaciers at these times, well after their withdrawal from the LGM, indicate an increase in precipitation or a decrease in temperature in this region. Although palaeoenvironmental records show regional and temporal variability, comparison with proxy records (lacustrine sediments and ice cores) indicate that regionally this was a cold, dry period so we ascribe these glacier advances to reduced atmospheric temperature rather than increased precipitation.

  11. Orally active analogues of the dopaminergic prodrug 6-(N,N-di-n-propylamino)-3,4,5,6,7,8-hexahydro-2H-naphthalen-1-one: synthesis and pharmacological activity.

    PubMed

    Venhuis, Bastiaan J; Dijkstra, Durk; Wustrow, David J; Meltzer, Leonard T; Wise, Lawrence D; Johnson, Stephen J; Heffner, Thomas G; Wikström, Håkan V

    2003-02-13

    A series of analogues of 6-(N,N-di-n-propylamino)-3,4,5,6,7,8-hexahydro-2H-naphthalen-1-one (6), an enone prodrug of the mixed DA D(1)/D(2) agonist 5,6-diOH-DPAT (2), was synthesized. The pharmacological profiles of these new enones and their in vivo pharmacological activities were investigated in the Ungerstedt rat rotation model for Parkinson's disease. At 0.1 mg kg(-1) po, the N-methyl-N-n-propyl (12) and the N-ethyl-N-propyl (13) analogues induced pronounced and long lasting pharmacological effects. The pharmacological profile of enone 12 was found to be similar to that of 6, while enone 13 was significantly more potent than 6 (p < 0.01). Analyses of rat brains after the administration of (-)-6 and 13 indicated the presence of hydroxylated metabolites of the parent enones. It is speculated that such metabolites are alpha'-hydroxylated enones that may constitute the first step in the formation of the corresponding catechols. PMID:12570379

  12. Crystal structure of 6,7-dihy­droxy-6,7-di­hydro-3H-imidazo[1,2-a]purin-9(5H)-one

    PubMed Central

    Guo, Wei; Li, Cheng-Xun; Lv, Jie; Wang, Jing

    2016-01-01

    The title purine derivative, C7H7N5O3, is an adduct of guanine with glyoxal. In the mol­ecule, the di­hydro­imidazole ring adopts a twisted conformation on the C—C bond, and the two hydroxyl groups lie on opposite sides of the mean plane of the ring. In the crystal, the mol­ecules are linked by N—H⋯O, O—H⋯N and N—H⋯N hydrogen bonds forming a three-dimensional framework. The crystal packing is reinforced by C—H⋯O hydrogen bonds and by offset π–π stacking of the purine ring systems of inversion related mol­ecules [inter­centroid distance = 3.4839 (12) Å]. PMID:27536400

  13. Molecular cloning, characterization and expression analysis of Wnt4, Wnt5, Wnt6, Wnt7, Wnt10 and Wnt16 from Litopenaeus vannamei.

    PubMed

    Zhang, Shuang; Li, Chao-Zheng; Yang, Qi-Hui; Dong, Xiao-Hui; Chi, Shu-Yan; Liu, Hong-Yu; Shi, Li-Li; Tan, Bei-Ping

    2016-07-01

    The Wnt (Wg-type MMTV integration site) signaling represents as the negative regulator of virus-induced innate immune responses. Wnt genes act as ligands to activate the Wnt signaling. To know more about the information of Wnt genes in invertebrates, Litopenaeus vannamei Wnt genes (LvWnts) were identified and characterized. In this study, Six Wnt genes (LvWnt4, LvWnt5, LvWnt6, LvWnt7, LvWnt10 and LvWnt16) were obtained in L. vannamei. The complete cDNAs open reading frames (ORF) of LvWnt4, LvWnt5, LvWnt6, LvWnt7, LvWnt10 and LvWnt16 were 1077 bp, 1107 bp, 1350 bp, 1047 bp, 1509 bp and 1158 bp (GenBank accession no. KU169896, KU169897, KU169898, KU169899, KU169900 and KU169901), encoding 358, 368, 449, 348, 502 and 385 amino acid (aa) residues respectively. All the six members of LvWnts contain a Wnt1 domain, which is considered as an important feature of Wnt gene family. ClustalW analysis with amino acid sequences revealed that the proportion of identity with other species was more than 48% for all the LvWnts except LvWnt10 (36-41%). The phylogenetic relationship analysis illustrated that different subtype of Wnts formed their own separate branches and were placed in branch of invertebrates respectively with strong bootstrap support. The constitutive expressions of LvWnts were confirmed by RT-PCR in all the examined five developmental stages and eleven tissues of L. vannamei with different express patterns. LvWnt4, LvWnt5 and LvWnt10 were expressed highest in nerve while LvWnt6, LvWnt7 and LvWnt16 were expressed highest in intestine, stomach and gill, respectively. In addition, all the LvWnts were regulated by white spot syndrome virus (WSSV) challenges at different levels in hepatopancreas, gill and hemocytes, suggesting that Wnt genes may play a role in the defense against pathogenic virus infection in innate immune of L. vannamei. PMID:27153750

  14. Cross-comparison of the IRS-P6 AWiFS sensor with the L5 TM, L7 ETM+, & Terra MODIS sensors

    USGS Publications Warehouse

    Chander, G.; Xiong, X.; Angal, A.; Choi, T.; Malla, R.

    2009-01-01

    As scientists and decision makers increasingly rely on multiple Earth-observing satellites to address urgent global issues, it is imperative that they can rely on the accuracy of Earth-observing data products. This paper focuses on the crosscomparison of the Indian Remote Sensing (IRS-P6) Advanced Wide Field Sensor (AWiFS) with the Landsat 5 (L5) Thematic Mapper (TM), Landsat 7 (L7) Enhanced Thematic Mapper Plus (ETM+), and Terra Moderate Resolution Imaging Spectroradiometer (MODIS) sensors. The cross-comparison was performed using image statistics based on large common areas observed by the sensors within 30 minutes. Because of the limited availability of simultaneous observations between the AWiFS and the Landsat and MODIS sensors, only a few images were analyzed. These initial results are presented. Regression curves and coefficients of determination for the top-of-atmosphere (TOA) trends from these sensors were generated to quantify the uncertainty in these relationships and to provide an assessment of the calibration differences between these sensors. ?? 2009 SPIE.

  15. Novel 3-Amino-6-chloro-7-(azol-2 or 5-yl)-1,1-dioxo-1,4,2-benzodithiazine Derivatives with Anticancer Activity: Synthesis and QSAR Study.

    PubMed

    Pogorzelska, Aneta; Sławiński, Jarosław; Brożewicz, Kamil; Ulenberg, Szymon; Bączek, Tomasz

    2015-01-01

    A series of new 3-amino-6-chloro-7-(azol-2 or 5-yl)-1,1-dioxo-1,4,2-benzodithiazine derivatives 5a-j have been synthesized and evaluated in vitro for their antiproliferative activity at the U.S. National Cancer Institute. The most active compound 5h showed significant cytotoxic effects against ovarian (OVCAR-3) and breast (MDA-MB-468) cancer (10% and 47% cancer cell death, respectively) as well as a good selectivity toward prostate (DU-145), colon (SW-620) and renal (TK-10) cancer cell lines. To obtain a deeper insight into the structure-activity relationships of the new compounds 5a-j QSAR studies have been applied. Theoretical calculations allowed the identification of molecular descriptors belonging to the RDF (RDF055p and RDF145m in the MOLT-4 and UO-31 QSAR models, respectively) and 3D-MorSE (Mor32m and Mor16e for MOLT-4 and UO-31 QSAR models) descriptor classes. Based on these data, QSAR models with good robustness and predictive ability have been obtained. PMID:26690109

  16. Molecular variants of human papilloma virus 16 E2, E4, E5, E6 and E7 genes associated with cervical neoplasia in Romanian patients.

    PubMed

    Plesa, Adriana; Anton, Gabriela; Iancu, Iulia V; Diaconu, Carmen C; Huica, Irina; Stanescu, Anca D; Socolov, Demetra; Nistor, Elena; Popa, Elena; Stoian, Mihai; Botezatu, Anca

    2014-12-01

    The aim of this study was to identify and associate the sequence variations of human Papillomavirus 16 (HPV16) genes from women who live in two different areas of Romania and associate them with malignant progression. One hundred twenty-four HPV16-positive cervical isolates were collected, and the E2, E4, E5, E6 and E7 viral genes were sequenced. Two new missense mutations in the E6 gene (C279G and A305C) were found (together or alone, in association with other mutations) in 44 of 124 cases. The most frequently simultaneously mutated genes were E4/E2 hinge, E5 and E6 (p = 0.0004) in squamous cell carcinoma (SCC) samples. Also, for SCC patients, the best-correlated mutation patterns were obtained for E4/E2 hinge-E5 (r = 0.7984; p < 0.0001). No sample was found to have all of the investigated viral genes concurrently mutated. Phylogenetic analysis was performed to characterize the viral variants. Similar results were found for SCC and cervical intraepithelial neoplasia III (CINIII) cases. After all of the target gene sequences were assembled, all patients were found to be infected with viruses of the HPV16- European-German (EG) lineage, and two clusters were identified, the first (55/96 variants) from Moldavia and the second (41/96 variants) from Bucharest. The distinct cluster derived from EG in Moldavia could partially explain the increased frequency of SCC in this area. This study has generated a comprehensive set of sequence variation data on HPV16 circulating in Romania to join the existing data and highlight the important role of HPV16 variants during cervical carcinogenesis. PMID:25143263

  17. H(2)O(2) increases de novo synthesis of (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin via GTP cyclohydrolase I and its feedback regulatory protein in vitiligo.

    PubMed

    Chavan, B; Beazley, W; Wood, J M; Rokos, H; Ichinose, H; Schallreuter, K U

    2009-02-01

    Patients with vitiligo accumulate up to 10(-3) mol/L concentrations of H(2)O(2) in their epidermis, which in turn affects many metabolic pathways in this compartment, including the synthesis and recycling of the cofactor (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (6BH(4)). De novo synthesis of 6BH(4) is dependent on the rate-limiting enzyme GTP cyclohydrolase I (GTPCHI) together with its feedback regulatory protein (GFRP). This step is controlled by 6BH(4) and the essential amino acid L-phenylalanine. In the study presented here we wanted to investigate whether H(2)O(2) affects the GTPCHI/GFRP cascade in these patients. Our results demonstrated concentration-dependent regulation of rhGTPCHI where 100 micromol/L H(2)O(2) was the optimum concentration for the activation of the enzyme and >300 micromol/L resulted in a decrease in activity. Oxidation of GFRP and GTPCHI does not affect feedback regulation via L-phenylalanine and 6BH(4). In vitiligo a constant upregulation of 6BH(4) de novo synthesis results from epidermal build up of L-phenylalanine that is not controlled by H(2)O(2). Taking the results together, 6BH(4) de novo synthesis is controlled by H(2)O(2) in a concentration-dependent manner, but H(2)O(2)-mediated oxidation does not affect the functionality of the GTPCHI/GFRP complex. PMID:19101819

  18. Subaru High-z Exploration of Low-luminosity Quasars (SHELLQs). I. Discovery of 15 Quasars and Bright Galaxies at 5.7 z > 6.9

    NASA Astrophysics Data System (ADS)

    Matsuoka, Yoshiki; Onoue, Masafusa; Kashikawa, Nobunari; Iwasawa, Kazushi; Strauss, Michael A.; Nagao, Tohru; Imanishi, Masatoshi; Niida, Mana; Toba, Yoshiki; Akiyama, Masayuki; Asami, Naoko; Bosch, James; Foucaud, Sébastien; Furusawa, Hisanori; Goto, Tomotsugu; Gunn, James E.; Harikane, Yuichi; Ikeda, Hiroyuki; Kawaguchi, Toshihiro; Kikuta, Satoshi; Komiyama, Yutaka; Lupton, Robert H.; Minezaki, Takeo; Miyazaki, Satoshi; Morokuma, Tomoki; Murayama, Hitoshi; Nishizawa, Atsushi J.; Ono, Yoshiaki; Ouchi, Masami; Price, Paul A.; Sameshima, Hiroaki; Silverman, John D.; Sugiyama, Naoshi; Tait, Philip J.; Takada, Masahiro; Takata, Tadafumi; Tanaka, Masayuki; Tang, Ji-Jia; Utsumi, Yousuke

    2016-09-01

    We report the discovery of 15 quasars and bright galaxies at 5.7 < z < 6.9. This is the initial result from the Subaru High-z Exploration of Low-Luminosity Quasars project, which exploits the exquisite multiband imaging data produced by the Subaru Hyper Suprime-Cam (HSC) Strategic Program survey. The candidate selection is performed by combining several photometric approaches including a Bayesian probabilistic algorithm to reject stars and dwarfs. The spectroscopic identification was carried out with the Gran Telescopio Canarias and the Subaru Telescope for the first 80 deg2 of the survey footprint. The success rate of our photometric selection is quite high, approaching 100% at the brighter magnitudes (z AB < 23.5 mag). Our selection also recovered all the known high-z quasars on the HSC images. Among the 15 discovered objects, six are likely quasars, while the other six with interstellar absorption lines and in some cases narrow emission lines are likely bright Lyman-break galaxies. The remaining three objects have weak continua and very strong and narrow Lyα lines, which may be excited by ultraviolet light from both young stars and quasars. These results indicate that we are starting to see the steep rise of the luminosity function of z ≥ 6 galaxies, compared with that of quasars, at magnitudes fainter than M 1450 ∼ ‑22 mag or z AB ∼ 24 mag. Follow-up studies of the discovered objects as well as further survey observations are ongoing.

  19. Subaru High-z Exploration of Low-luminosity Quasars (SHELLQs). I. Discovery of 15 Quasars and Bright Galaxies at 5.7 z > 6.9

    NASA Astrophysics Data System (ADS)

    Matsuoka, Yoshiki; Onoue, Masafusa; Kashikawa, Nobunari; Iwasawa, Kazushi; Strauss, Michael A.; Nagao, Tohru; Imanishi, Masatoshi; Niida, Mana; Toba, Yoshiki; Akiyama, Masayuki; Asami, Naoko; Bosch, James; Foucaud, Sébastien; Furusawa, Hisanori; Goto, Tomotsugu; Gunn, James E.; Harikane, Yuichi; Ikeda, Hiroyuki; Kawaguchi, Toshihiro; Kikuta, Satoshi; Komiyama, Yutaka; Lupton, Robert H.; Minezaki, Takeo; Miyazaki, Satoshi; Morokuma, Tomoki; Murayama, Hitoshi; Nishizawa, Atsushi J.; Ono, Yoshiaki; Ouchi, Masami; Price, Paul A.; Sameshima, Hiroaki; Silverman, John D.; Sugiyama, Naoshi; Tait, Philip J.; Takada, Masahiro; Takata, Tadafumi; Tanaka, Masayuki; Tang, Ji-Jia; Utsumi, Yousuke

    2016-09-01

    We report the discovery of 15 quasars and bright galaxies at 5.7 < z < 6.9. This is the initial result from the Subaru High-z Exploration of Low-Luminosity Quasars project, which exploits the exquisite multiband imaging data produced by the Subaru Hyper Suprime-Cam (HSC) Strategic Program survey. The candidate selection is performed by combining several photometric approaches including a Bayesian probabilistic algorithm to reject stars and dwarfs. The spectroscopic identification was carried out with the Gran Telescopio Canarias and the Subaru Telescope for the first 80 deg2 of the survey footprint. The success rate of our photometric selection is quite high, approaching 100% at the brighter magnitudes (z AB < 23.5 mag). Our selection also recovered all the known high-z quasars on the HSC images. Among the 15 discovered objects, six are likely quasars, while the other six with interstellar absorption lines and in some cases narrow emission lines are likely bright Lyman-break galaxies. The remaining three objects have weak continua and very strong and narrow Lyα lines, which may be excited by ultraviolet light from both young stars and quasars. These results indicate that we are starting to see the steep rise of the luminosity function of z ≥ 6 galaxies, compared with that of quasars, at magnitudes fainter than M 1450 ˜ ‑22 mag or z AB ˜ 24 mag. Follow-up studies of the discovered objects as well as further survey observations are ongoing.

  20. Soft magnetic properties of Fe(87- x)Ti7Zr6[B x Si x ]0.5 amorphous metallic ribbons prepared by melt-spinning

    NASA Astrophysics Data System (ADS)

    Han, Bo-Kyeong; Choi-Yim, Haein

    2014-01-01

    The soft magnetic Fe-based amorphous metallic ribbons Fe(87- x)Ti7Zr6[B x Si x ]0.5 (x = 8, 10, 12%) were prepared using the melt-spinning technique to have thickness of 15-22 μm and widths of 1-2 mm. Increasing the amounts of B and Si improved the soft magnetic properties: the coercivity ( H c) decreased, and the saturation magnetization ( M S) increased, the thermal and structural properties remained the same. Due to the high sensitivity of the alloys to the process conditions, variations in the widths of the melt-spun ribbons induced structural modifications, resulting in significant change in the soft magnetic properties. While the ribbons made with 1 mm widths had fully amorphous structures and soft magnetic properties, the ribbons with 2 mm widths showed semi-hard magnetic properties, which was attributed to the formation of nanocrystals inside the amorphous structures.

  1. Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators (Part 2).

    PubMed

    Takai, Takafumi; Koike, Tatsuki; Nakamura, Minoru; Kajita, Yuichi; Yamashita, Toshiro; Taya, Naohiro; Tsukamoto, Tetsuya; Watanabe, Tomomichi; Murakami, Koji; Igari, Tomoko; Kamata, Makoto

    2016-07-15

    γ-Secretase modulators (GSMs), which lower pathogenic amyloid beta (Aβ) without affecting the production of total Aβ or Notch signal, have emerged as a potential therapeutic agent for Alzheimer's disease (AD). A novel series of 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives was discovered and characterized as GSMs. Optimization of substituents at the 8-position of the core scaffold using ligand-lipophilicity efficiency (LLE) as a drug-likeness guideline led to identification of various types of high-LLE GSMs. Phenoxy compound (R)-17 exhibited especially high LLE as well as potent in vivo Aβ42-lowering effect by single administration. Furthermore, multiple oral administration of (R)-17 significantly reduced soluble and insoluble brain Aβ42, and ameliorated cognitive deficit in novel object recognition test (NORT) using Tg2576 mice as an AD model. PMID:27255179

  2. Synthesis and Spectral Characterization of Benzo-[6,7][1,5]diazocino[2,1-a]isoindol-12-(14H)-one Derivatives.

    PubMed

    Bassin, Jatinder P; Anagani, Bhavani; Benham, Christopher; Goyal, Madhu; Hashemian, Maryam; Gerhard, Ute

    2016-01-01

    A simple synthetic route affording 27%-85% yields of benzo[6,7][1,5]diazocino[2,1-a]isoindol-12(14H)-one ring systems from readily available 3-(2-oxo-2-phenylethyl) isobenzofuran-1(3H)-ones and 2-(aminomethyl)aniline starting materials in toluene and catalysed by p-toluene-sulfonic acid is developed. The ¹H- and (13)C-NMR spectra of the final products were assigned using a variety of one and two-dimensional NMR experiments. The distinction between the two potential isomers of the final products was made on the basis of heteronuclear multiple bond connectivity (HMBC) NMR spectra. PMID:27455232

  3. A 0.7 Mb de novo duplication at 7q21.3 including the genes DLX5 and DLX6 in a patient with split-hand/split-foot malformation.

    PubMed

    Velinov, Milen; Ahmad, Ausaf; Brown-Kipphut, Brigette; Shafiq, Mustafa; Blau, Jonathan; Cooma, Ruby; Roth, Philip; Iqbal, M Anwar

    2012-12-01

    Split-hand/split-foot malformation (SHFM1) has been reported to be caused by deletions, duplications or rearrangements involving the 7q21.3 region harboring DSS1, DLX5, and DLX6. We report on a female patient with unilateral syndactyly of the third and fourth fingers of the right hand and overgrowth and lateral deviation of the right great toe. There was a split foot malformation on the right, with absent fifth toe. The left hand was apparently normal and left foot was intact. The patient has no hearing loss. We performed conventional G-banding karyotype analysis, array comparative genomic hybridization (aCGH) and fluorescence in situ hybridization (FISH). G-banding karyotype result was normal 46,XX. However, a duplication of 719 kb (96,303,736-97,022,335; NCBI build36/hg18, March 2006) was identified at the 7q21.3 region by aCGH. The array result was also confirmed by FISH analysis. The duplicated region harbors only DLX5 and DLX6, which are known for their role in SHFM1. Additionally, FISH analysis of parental samples showed de novo origin of this abnormality in the patient. This is the first report that highlights the duplication of 719 kb at 7q21.3, harboring only DLX5 and DLX6 associated with the SHFM1 phenotype. PMID:23169702

  4. 7 CFR 550.5 - Competition.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Competition. 550.5 Section 550.5 Agriculture... Competition. REE agencies may enter into non-assistance cooperative agreements, as authorized by this part, without regard to any requirements for competition. (7 U.S.C. 3318(e))....

  5. 7 CFR 550.5 - Competition.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Competition. 550.5 Section 550.5 Agriculture... Competition. REE agencies may enter into non-assistance cooperative agreements, as authorized by this part, without regard to any requirements for competition. (7 U.S.C. 3318(e))....

  6. 7 CFR 550.5 - Competition.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Competition. 550.5 Section 550.5 Agriculture... Competition. REE agencies may enter into non-assistance cooperative agreements, as authorized by this part, without regard to any requirements for competition. (7 U.S.C. 3318(e))....

  7. 7 CFR 550.5 - Competition.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Competition. 550.5 Section 550.5 Agriculture... Competition. REE agencies may enter into non-assistance cooperative agreements, as authorized by this part, without regard to any requirements for competition. (7 U.S.C. 3318(e))....

  8. 7 CFR 550.5 - Competition.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Competition. 550.5 Section 550.5 Agriculture... Competition. REE agencies may enter into non-assistance cooperative agreements, as authorized by this part, without regard to any requirements for competition. (7 U.S.C. 3318(e))....

  9. Comparison of Two Widely Used Human Papillomavirus Detection and Genotyping Methods, GP5+/6+-Based PCR Followed by Reverse Line Blot Hybridization and Multiplex Type-Specific E7-Based PCR.

    PubMed

    Clifford, Gary M; Vaccarella, Salvatore; Franceschi, Silvia; Tenet, Vanessa; Umulisa, M Chantal; Tshomo, Ugyen; Dondog, Bolormaa; Vorsters, Alex; Tommasino, Massimo; Heideman, Daniëlle A M; Snijders, Peter J F; Gheit, Tarik

    2016-08-01

    GP5+/6+-based PCR followed by reverse line blot hybridization (GP5+/6+RLB) and multiplex type-specific PCR (E7-MPG) are two human papillomavirus (HPV) genotyping methodologies widely applied in epidemiological research. We investigated their relative analytical performance in 4,662 samples derived from five studies in Bhutan, Rwanda, and Mongolia coordinated by the International Agency for Research on Cancer (IARC). A total of 630 samples were positive by E7-MPG only (13.5%), 24 were positive by GP5+/6+RLB only (0.5%), and 1,014 were positive (21.8%) by both methods. Ratios of HPV type-specific positivity of the two tests (E7-MPG:GP5+/6+RLB ratio) were calculated among 1,668 samples that were HPV positive by one or both tests. E7-MPG:GP5+/6+RLB ratios were >1 for all types and highly reproducible across populations and sample types. E7-MPG:GP5+/6+RLB ratios were highest for HPV53 (7.5) and HPV68 (7.1). HPV16 (1.6) and HPV18 (1.7) had lower than average E7-MPG:GP5+/6+RLB ratios. Among E7-MPG positive infections, median mean fluorescence intensity (MFI; a semiquantitative measure of viral load) tended to be higher among samples positive for the same virus type by GP5+/6+RLB than for those negative for the same type by GP5+/6+RLB. Exceptions, however, included HPV53, -59, and -82, for which the chances of being undetected by GP5+/6+RLB appeared to be MFI independent. Furthermore, the probability of detecting an additional type by E7-MPG was higher when another type was already detected by GP5+/6+RLB, suggesting the existence of masking effects due to competition for GP5+/6+ PCR primers. In conclusion, this analysis is not an evaluation of clinical performance but may inform choices for HPV genotyping methods in epidemiological studies, when the relative merits and dangers of sensitivity versus specificity for individual types should be considered, as well as the potential to unmask nonvaccine types following HPV vaccination. PMID:27225411

  10. 6 CFR 7.30 - Classification challenges.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 CFR 7.31. ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Classification challenges. 7.30 Section 7.30 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL...

  11. 6 CFR 7.30 - Classification challenges.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 6 CFR 7.31. ... 6 Domestic Security 1 2014-01-01 2014-01-01 false Classification challenges. 7.30 Section 7.30 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL...

  12. Far-field triggering of foreshocks near the nucleation zone of the 5 September 2012 (MW 7.6) Nicoya Peninsula, Costa Rica earthquake

    NASA Astrophysics Data System (ADS)

    Walter, Jacob I.; Meng, Xiaofeng; Peng, Zhigang; Schwartz, Susan Y.; Newman, Andrew V.; Protti, Marino

    2015-12-01

    On 5 September 2012, a moment magnitude (MW) 7.6 earthquake occurred directly beneath the Nicoya Peninsula, an area with dense seismic and geodetic network coverage. The mainshock ruptured a portion of a previously identified locked patch that was recognized due to a decade-long effort to delineate the megathrust seismic and aseismic processes in this area. Here we conduct a comprehensive study of the seismicity prior to this event utilizing a matched-filter analysis that allows us to decrease the magnitude of catalog completeness by 1 unit. We observe a statistically significant increase in seismicity rate below the Nicoya Peninsula following the 27 August 2012 (MW 7.3) El Salvador earthquake (about 450 km to the northwest and 9 days prior to the Nicoya earthquake). Additionally, we identify a cluster of small-magnitude (<2.2) earthquakes preceding the mainshock by about 35 min and within 15 km of its hypocenter. The immediate foreshock sequence occurred in the same area as those earthquakes triggered shortly after the El Salvador event; though it is not clear whether the effect of triggering from the El Salvador event persisted until the foreshock sequence given the uncertainties in seismicity rates from a relatively small number of earthquakes. If megathrust earthquakes at such distances can induce significant increases in seismicity during the days before another larger event, this sequence strengthens the need for real-time seismicity monitoring for large earthquake forecasting.

  13. Protective effects of 5,7,4'-trihydroxy-6,3'dimethoxy-flavone 5-O-α-l-rhamnopyranoside, isolated from Annona squamosa leaves in thyrotoxicosis and in hepatic lipid peroxidation in rats.

    PubMed

    Panda, Sunanda; Kar, Anand

    2015-12-15

    Hitherto unknown protective effects of 5,7,4'-trihydroxy-6,3'dimethoxy-flavone 5-O-α-l-rhamnopyranoside (THDMF-Rha); isolated from Annona squamosa leaves were evaluated in l-thyroxine (l-T4)-induced thyrotoxicosis in rats. Administration of l-T4 at 500μg/kg body weight for 12days increased the levels of serum thyroid hormones, the activity of 5'-monodeiodinase-I (5'DI) and hepatic glucose-6-phosphatase (G-6Pase) as well as lipid peroxidation (LPO); with a parallel decrease in the levels of cellular antioxidants and serum lipids. However, administration of the isolated THDMF-Rha at a pre-standardized dose for 15days ameliorated the l-T4-induced alterations in the levels of thyroid hormones, hepatic LPO, G-6-Pase, 5'DI activity, and cellular levels of antioxidants and improved the status of different serum lipids, suggesting its antithyroidal and antioxidative potential. As compared to standard antithyroid drug, propylthiouracil, THDMF-Rha appeared to be more promising. PMID:26547692

  14. Oxidative Dearomatization of 4,5,6,7-Tetrahydro-1H-indoles Obtained by Metal- and Solvent-Free Thermal 5-endo-dig Cyclization: The Route to Erythrina and Lycorine Alkaloids.

    PubMed

    Andreev, Ivan A; Ratmanova, Nina K; Novoselov, Anton M; Belov, Dmitry S; Seregina, Irina F; Kurkin, Alexander V

    2016-05-17

    A facile one-pot approach based on a thermally induced metal- and solvent-free 5-endo-dig cyclization reaction of the amino propargylic alcohols in combination with Dess-Martin periodinane-promoted oxidative dearomatization of 4,5,6,7-tetrahydroindole intermediates provides an efficient and robust access to 5,6-dihydro-1H-indol-2(4H)ones. Green, relatively mild and operationally simple characteristics of the synthetic sequence are the major advantages, which greatly amplify the developed methodology. The utility of obtained indolones as unified key precursors is demonstrated by the application of these products to the formal total syntheses of a whole pleiad of Erythrina- and Lycorine-type alkaloids, namely (±)-erysotramidine, (±)-erysotrine, (±)-erythravine, (±)-γ-lycorane, and abnormal erythrinanes (±)-coccoline and (±)-coccuvinine. PMID:27076115

  15. Synthesis, anticancer activity, and SAR analyses of compounds containing the 5:7-fused 4,6,8-triaminoimidazo[4,5-e][1,3]diazepine ring system.

    PubMed

    Xie, Min; Lapidus, Rena G; Sadowska, Mariola; Edelman, Martin J; Hosmane, Ramachandra S

    2016-06-15

    Described herein are our limited structure-activity relationship (SAR) studies on a 5:7-fused heterocycle (1), containing the 4,6,8-triaminoimidazo[4,5-e][1,3]diazepine ring system, whose synthesis and potent broad-spectrum anticancer activity we reported a few years ago. Our SAR efforts in this study are mainly focused on judicial attachment of substituents at N-1 and N(6)-positions of the heterocyclic ring. Our results suggest that there is some subtle correlation between the substituents attached at the N-1 position and those attached at the N(6)-position of the heterocycle. It is likely that there is a common hydrophobic binding pocket on the target protein that is occupied by the substituents attached at the N-1 and N(6)-positions of the heterocyclic ligand. This pocket appears to be large enough to hold either a C-18 alkyl chain of N(6) and no attachment at N-1, or a combined C-10 at N(6) and a CH2Ph at N-1. Any alkyl chain shorter or longer than C-10 at N(6) with a CH2Ph attached at N-1, would result in decrease of biological activity. PMID:27134120

  16. Structure Revision of (22E)-Ergosta-7,22-diene-3β,5α,6β,9α,14α- pentol from the Spores of the Medicinal Mushroom Ganoderma lucidum.

    PubMed

    Yaoita, Yasunori; Machida, Koichi

    2016-02-01

    Careful reexamination of the published ¹H and ¹³C NMR spectral data of (22E)-ergosta-7,22-diene-3β,5α,6β,9α,14α-pentol (1), isolated from the spores of the medicinal mushroom Ganoderma lucidum, indicates that, in reality, the compound is (22E)-ergosta-7,22-diene-3β,5α,6β,9α,14β-pentol (5). PMID:27032196

  17. Measurement of the {sup 241}Am(n,2n) reaction cross section from 7.6 MeV to 14.5 MeV

    SciTech Connect

    Tonchev, A. P.; Crowell, A. S.; Fallin, B.; Howell, C. R.; Hutcheson, A.; Tornow, W.; Angell, C. T.; Boswell, M.; Hammond, S.; Karwowski, H. J.; Kelley, J. H.; Pedroni, R. S.; Becker, J. A.; Dashdorj, D.; Kenneally, J.; Macri, R. A.; Stoyer, M. A.; Wu, C. Y.; Bond, E.; Chadwick, M. B.

    2008-05-15

    The (n,2n) cross section of the radioactive isotope {sup 241}Am (T{sub 1/2}=432.6 y) has been measured in the incident neutron energy range from 7.6 to 14.5 MeV in steps of a few MeV using the activation technique. Monoenergetic neutron beams were produced via the {sup 2}H(d,n){sup 3}He reaction by bombarding a pressurized deuterium gas cell with an energetic deuteron beam at the TUNL 10-MV Van de Graaff accelerator facility. The induced {gamma}-ray activity of {sup 240}Am was measured with high-resolution HPGe detectors. The cross section was determined relative to Al, Ni, and Au neutron activation monitor foils, measured in the same geometry. Good agreement is obtained with previous measurements at around 9 and 14 MeV, whereas for a large discrepancy is observed when our data are compared to those reported by Perdikakis et al. near 11 MeV. Very good agreement is found with the END-B/VII evaluation, whereas the JENDL-3.3 evaluation is in fair agreement with our data.

  18. Efficient blue organic light-emitting diodes using N(2) ,N(2) ,N(11) ,N(11) ,5,6,7,8-octaphenyltriphenylene-2,11-diamine derivatives.

    PubMed

    Kim, Young Seok; Jeong, Su Jin; Lee, Hyun Woo; Kim, Jwajin; Lee, Song Eun; Kim, Young Kwan; Yoon, Seung Soo

    2016-06-01

    In this study, we have synthesized phenyl-substituted triphenylene derivatives, using the Diels-Alder reaction and the Buchwald-Hartwig reaction. To investigate electroluminescence properties of these materials, multilayer organic light-emitting diode (OLED) devices were fabricated with a structure of indium-tin-oxide (ITO) (180 nm)/4,4'-bis(N-(1-naphthyl)-N-phenylamino)biphenyl (NPB) (50 nm)/blue-emitting materials (1-3) (30 nm)/bathophenanthroline (Bphen) (35 nm)/lithium quinolate (Liq) (2 nm)/Al (100 nm). A device using N(2) ,N(2) ,N(11) ,N(11) ,5,6,7-heptaphenyltriphenylene-2,11-diamine (2) exhibited efficient blue emission with luminous, power, and external quantum efficiencies of 0.92 cd/A, 0.67 lm/W, and 1.17% at 20 mA/cm(2) , respectively. The Commission International de L'Éclairage coordinates of this device were (x = 0.15, y = 0.09) at 6.0 V. Copyright © 2015 John Wiley & Sons, Ltd. PMID:26693664

  19. Synthesis, characterization, and antimicrobial activity of silver carbene complexes derived from 4,5,6,7-tetrachlorobenzimidazole against antibiotic resistant bacteria†

    PubMed Central

    Wright, Brian D.; Shah, Parth N.; McDonald, Lucas J.; Shaeffer, Michael L.; Wagers, Patrick O.; Panzner, Matthew J.; Smolen, Justin; Tagaev, Jasur; Tessier, Claire A.

    2013-01-01

    Silver N-heterocyclic carbene complexes have been shown to have great potential as antimicrobial agents, affecting a wide spectrum of both Gram-positive and Gram-negative bacteria. A new series of three silver carbene complexes (SCCs) based on 4,5,6,7-tetrachlorobenzimidazole has been synthesized, characterized, and tested against a panel of clinical strains of bacteria. The imidazolium salts and their precursors were characterized by elemental analysis, mass spectrometry, 1H and 13C NMR spectroscopy, and single crystal X-ray diffraction. The silver carbene complexes, SCC32, SCC33, and SCC34 were characterized by elemental analysis, 1H and 13C NMR spectroscopy, and single crystal X-ray diffraction. These complexes proved highly efficacious with minimum inhibitory concentrations (MICs) ranging from 0.25 to 6 μg mL−1. Overall, the complexes were effective against highly resistant bacteria strains, such as methicillin-resistant Staphylococcus aureus (MRSA), weaponizable bacteria, such as Yersinia pestis, and pathogens found within the lungs of cystic fibrosis patients, such as Pseudomonas aeruginosa, Alcaligenes xylosoxidans, and Burkholderia gladioli. SCC33 and SCC34 also showed clinically relevant activity against a silver-resistant strain of Escherichia coli based on MIC testing. PMID:22402409

  20. An anti-sepsis monomer, 2',5,6',7-tetrahydroxyflavanonol (THF), identified from Scutellaria baicalensis Georgi neutralizes lipopolysaccharide in vitro and in vivo.

    PubMed

    Fu, Jianfeng; Cao, Hongwei; Wang, Ning; Zheng, Xinchun; Lu, Yongling; Liu, Xin; Yang, Dong; Li, Bin; Zheng, Jiang; Zhou, Hong

    2008-12-10

    Lipopolysaccharide (LPS) is a known trigger in the pathogenesis of sepsis, lipid A being the toxic component. One of several adjuvant therapeutic approaches for severe sepsis is currently focusing on the neutralization of LPS. In order to obtain the components from traditional Chinese herbs that can neutralize the endotoxin, aqueous extractions of twelve herbs were tested using affinity biosensor technology. From twelve herbs, Scutellaria baicalensis Georgi (Huang Qin) found to possess high lipid A-binding abilities, and was selected in subsequent experiments. After subjected to macroporous adsorptive resins and HPLC, we obtained 2',5,6',7-tetrahydroxyflavanonol (THF) from S. baicalensis Georgi under the direction of neutralization of LPS and reducing proinflammatory cytokines. In vitro, THF directly bound to LPS and neutralized its activity. THF not only down-regulated TNF-alpha mRNA expression but also decreased TNF-alpha and IL-6 release from RAW264.7 cells induced by LPS in a dose-dependent manner. THF-mediated inhibition on proinflammatory cytokine release is probably associated with downregulation of LPS-induced TLR4 mRNA augmentation. In vivo, THF could significantly protect mice against a lethal challenge with heat-killed E. coli 35218 (E. coli 35218) in a dose-dependent manner, and decreased the plasma LPS level in endotoxemia mice. These findings provide compelling evidence that THF may be an important potential drug for sepsis treatment. Considering the inhibitory effects of THF on LPS-induced cytokine release are unlikely due to its nonspecific cellular toxicity, THF should be considered as a safe putative candidate for development as a drug for sepsis treatment. PMID:18755299

  1. ELECTRON-ION RECOMBINATION OF Mg{sup 6+} FORMING Mg{sup 5+} AND OF Mg{sup 7+} FORMING Mg{sup 6+}: LABORATORY MEASUREMENTS AND THEORETICAL CALCULATIONS

    SciTech Connect

    Lestinsky, M.; Hahn, M.; Novotny, O.; Savin, D. W.; Badnell, N. R.; Bernhardt, D.; Mueller, A.; Schippers, S.; Bing, D.; Grieser, M.; Hoffmann, J.; Jordon-Thaden, B.; Krantz, C.; Orlov, D. A.; Repnow, R.; Shornikov, A.; Wolf, A.

    2012-10-10

    We have measured electron-ion recombination for C-like Mg{sup 6+} forming Mg{sup 5+}, and for B-like Mg{sup 7+} forming Mg{sup 6+}. These studies were performed using a merged electron-ion beam arrangement at the TSR heavy ion storage ring located in Heidelberg, Germany. Both primary ions have metastable levels with significant lifetimes. Using a simple cascade model we estimate the population fractions in these metastable levels. For the Mg{sup 6+} results, we find that the majority of the stored ions are in a metastable level, while for Mg{sup 7+} the metastable fraction is insignificant. We present the Mg{sup 6+} merged beams recombination rate coefficient for DR via N = 2 {yields} N' = 2 core electron excitations ({Delta}N = 0 DR) and for Mg{sup 7+} via 2 {yields} 2 and 2 {yields} 3 core excitations. Taking the estimated metastable populations into account, we compare our results to state-of-the-art multiconfiguration Breit-Pauli theoretical calculations. Significant differences are found at low energies where theory is known to be unreliable. Moreover, for both ions we observe a discrepancy between experiment and theory for {Delta}N = 0 DR involving capture into high-n Rydberg levels and where the stabilization is primarily due to a radiative transition of the excited core electron. This is consistent with previous DR experiments on M-shell iron ions which were performed at TSR. The large metastable content of the Mg{sup 6+} ion beam precludes generating a plasma recombination rate coefficient (PRRC). However, this is not an issue for Mg{sup 7+} and we present an experimentally derived Mg{sup 7+} PRRC for plasma temperatures from 400 K to 10{sup 7} K with an estimated uncertainty of less than 27% at a 90% confidence level. We also provide a fit to our experimentally derived PRRC for use in plasma modeling codes.

  2. Anti-inflammatory effect of the 5,7,4'-trihydroxy-6-geranylflavanone isolated from the fruit of Artocarpus communis in S100B-induced human monocytes.

    PubMed

    Lin, Jer-An; Fang, Song-Chwan; Wu, Chi-Hao; Huang, Shang-Ming; Yen, Gow-Chin

    2011-01-12

    The fruit of Artocarpus communis Moraceae, a traditional starch crop, is a rich source of phytochemicals, such as flavonoids and their derivatives. The aim of this study was to investigate whether 5,7,4'-trihydroxy-6-geranylflavanone (AC-GF), a geranyl flavonoid derivative isolated from the fruits of A. communis, could decrease the activation of inflammatory mediators induced by S100B (ligand of receptor for advanced glycation end products, RAGE) in THP-1 monocytes. According to the results, low levels of AC-GF (≤2.5 μM) showed a great inhibitory effect on gene expression of RAGE and down-regulated both TNF-α and IL-1β secretion and gene expression (p < 0.05). AC-GF also decreased reactive oxygen species (ROS) production in response to S100B (p < 0.05). Additionally, Western blotting revealed that AC-GF could effectively attenuate RAGE-dependent signaling, including expression of protein kinase C (PKC) and p47phox, phosphorylation of extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK), and particularly NF-κB activation (p < 0.05). In conclusion, this is the first report that AC-GF possesses great antioxidant and anti-inflammatory properties in vitro. This finding may contribute to increased implication and utilization of the fruit of A. communis Moraceae in functional foods. PMID:21126004

  3. Kinematics of the standardbred trotter measured at 6, 7, 8 and 9 m/s on a treadmill, before and after 5 months of prerace training.

    PubMed

    van Weeren, P R; van den Bogert, A J; Back, W; Bruin, G; Barneveld, A

    1993-01-01

    A kinematic study was performed on a group of 8 Standardbred stallions. Recordings were done using a modified CODA-3 optoelectronic kinematic analysis system with the horses running on a treadmill at speeds of 6, 7, 8, or 9 m/s. Linear and temporal gait characteristics, joint angle diagrams and the trajectories of the hoof in a plane perpendicular to the direction of movement were studied. Two consecutive recording sessions were held at an age of 21-23 months, and a third was held 5 months later after an intensive training period. Joint angle diagrams appeared to show a similar pattern for all horses though certain individual characteristics could be identified. Only a few kinematic parameters appeared to have significantly changed after the 5-month training period (p < 0.05). The hoof trajectories showed marked and consistent differences between front and hind hooves, but the most striking feature was the very individual character of the patterns exhibited, leading to the assumption that these patterns could possibly be used as the 'fingerprint' of the horse. PMID:8470459

  4. The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists.

    PubMed

    Rech, Jason C; Bhattacharya, Anindya; Branstetter, Bryan J; Love, Christopher J; Leenaerts, Joseph E; Cooymans, Ludwig P; Eckert, William A; Ao, Hong; Wang, Qi; Chaplan, Sandra R; Wickenden, Alan D; Lebsack, Alec D; Breitenbucher, J Guy

    2016-10-01

    The synthesis, SAR and preclinical characterization of a series of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists is described herein. The lead compounds are potent inhibitors in Ca(2+) flux and whole blood IL-1β P2X7 release assays at both human and mouse isoforms. Compound 1e showed a robust reduction of IL-1β release in a mouse ex vivo model with a 50mg/kg oral dose. Evaluation of compound 1e in the mouse SNI tactile allodynia, carrageenan-induced paw edema or CIA models resulted in no analgesic or anti-inflammatory effects. PMID:27595421

  5. 7 CFR 501.5 - Nuisances.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Nuisances. 501.5 Section 501.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.5 Nuisances. The use of...

  6. 7 CFR 501.5 - Nuisances.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Nuisances. 501.5 Section 501.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.5 Nuisances. The use of...

  7. 7 CFR 501.5 - Nuisances.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Nuisances. 501.5 Section 501.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.5 Nuisances. The use of...

  8. 7 CFR 501.5 - Nuisances.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Nuisances. 501.5 Section 501.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.5 Nuisances. The use of...

  9. 7 CFR 502.5 - Nuisances.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Nuisances. 502.5 Section 502.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON BELTSVILLE AGRICULTURE RESEARCH CENTER PROPERTY, BELTSVILLE, MARYLAND § 502.5 Nuisances. The use of loud, abusive or otherwise...

  10. 7 CFR 500.5 - Nuisances.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Nuisances. 500.5 Section 500.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE NATIONAL ARBORETUM Conduct on U.S. National Arboreturm Property § 500.5 Nuisances. (a) The use of loud, abusive, or otherwise improper...

  11. 7 CFR 501.5 - Nuisances.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Nuisances. 501.5 Section 501.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.5 Nuisances. The use of loud, abusive, or otherwise improper...

  12. 7 CFR 1781.5 - Eligibility.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 12 2014-01-01 2013-01-01 true Eligibility. 1781.5 Section 1781.5 Agriculture... construction facilities. (6) Health and sanitation standards, water pollution control, and environmental... loans. (3) Land use zoning. (4) Acquiring necessary property, lands, and rights. (5) Obtaining...

  13. 7 CFR 625.5 - Application procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Application procedures. 625.5 Section 625.5 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE WATER RESOURCES HEALTHY FORESTS RESERVE PROGRAM § 625.5 Application procedures....

  14. 7 CFR 623.5 - Ineligible land.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Ineligible land. 623.5 Section 623.5 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE WATER RESOURCES EMERGENCY WETLANDS RESERVE PROGRAM § 623.5 Ineligible land. Notwithstanding...

  15. 7 CFR 633.5 - Application procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Application procedures. 633.5 Section 633.5 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING WATER BANK PROGRAM § 633.5 Application procedures. (a) Application for participation. To apply...

  16. 7 CFR 502.5 - Nuisances.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Nuisances. 502.5 Section 502.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON BELTSVILLE AGRICULTURE RESEARCH CENTER PROPERTY, BELTSVILLE, MARYLAND § 502.5 Nuisances....

  17. 7 CFR 503.5 - Nuisances.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Nuisances. 503.5 Section 503.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON PLUM ISLAND ANIMAL DISEASE CENTER § 503.5 Nuisances. The use of loud, abusive or...

  18. 7 CFR 503.5 - Nuisances.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Nuisances. 503.5 Section 503.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON PLUM ISLAND ANIMAL DISEASE CENTER § 503.5 Nuisances. The use of loud, abusive or...

  19. 7 CFR 503.5 - Nuisances.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Nuisances. 503.5 Section 503.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON PLUM ISLAND ANIMAL DISEASE CENTER § 503.5 Nuisances. The use of loud, abusive or...

  20. 7 CFR 503.5 - Nuisances.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Nuisances. 503.5 Section 503.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON PLUM ISLAND ANIMAL DISEASE CENTER § 503.5 Nuisances. The use of loud, abusive or...

  1. 7 CFR 503.5 - Nuisances.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Nuisances. 503.5 Section 503.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON PLUM ISLAND ANIMAL DISEASE CENTER § 503.5 Nuisances. The use of loud, abusive or...

  2. 7 CFR 600.5 - Area offices.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Area offices. 600.5 Section 600.5 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE GENERAL ORGANIZATION § 600.5 Area offices. Each area office is under the direction and...

  3. 7 CFR 600.5 - Area offices.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Area offices. 600.5 Section 600.5 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE GENERAL ORGANIZATION § 600.5 Area offices. Each area office is under the direction and...

  4. 7 CFR 658.5 - Criteria.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Criteria. 658.5 Section 658.5 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE SUPPORT ACTIVITIES FARMLAND PROTECTION POLICY ACT § 658.5 Criteria. This section states the criteria required by section 1541(a) of the...

  5. 7 CFR 658.5 - Criteria.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Criteria. 658.5 Section 658.5 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE SUPPORT ACTIVITIES FARMLAND PROTECTION POLICY ACT § 658.5 Criteria. This section states the criteria required by section 1541(a) of the...

  6. 7 CFR 510.5 - Denials.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Denials. 510.5 Section 510.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE PUBLIC INFORMATION § 510.5 Denials. If the FOIA Coordinator determines that a requested record is...

  7. 7 CFR 500.5 - Nuisances.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Nuisances. 500.5 Section 500.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE NATIONAL ARBORETUM Conduct on U.S. National Arboreturm Property § 500.5 Nuisances. (a) The use of...

  8. 7 CFR 613.5 - PMCs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false PMCs. 613.5 Section 613.5 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE CONSERVATION OPERATIONS PLANT MATERIALS CENTERS § 613.5 PMCs. (a) The Norman A. Berg National PMC. The Norman A. Berg National PMC...

  9. 7 CFR 504.5 - Address.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Address. 504.5 Section 504.5 Agriculture Regulations... USER FEES § 504.5 Address. Deposits of and requests for microbial patent cultures should be directed to.... University St., Peoria, Illinois 61604; (309) 685-4011....

  10. 7 CFR 504.5 - Address.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Address. 504.5 Section 504.5 Agriculture Regulations... USER FEES § 504.5 Address. Deposits of and requests for microbial patent cultures should be directed to.... University St., Peoria, Illinois 61604; (309) 685-4011....

  11. 7 CFR 504.5 - Address.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Address. 504.5 Section 504.5 Agriculture Regulations... USER FEES § 504.5 Address. Deposits of and requests for microbial patent cultures should be directed to.... University St., Peoria, Illinois 61604; (309) 685-4011....

  12. 7 CFR 504.5 - Address.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Address. 504.5 Section 504.5 Agriculture Regulations... USER FEES § 504.5 Address. Deposits of and requests for microbial patent cultures should be directed to.... University St., Peoria, Illinois 61604; (309) 685-4011....

  13. 7 CFR 504.5 - Address.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Address. 504.5 Section 504.5 Agriculture Regulations... USER FEES § 504.5 Address. Deposits of and requests for microbial patent cultures should be directed to.... University St., Peoria, Illinois 61604; (309) 685-4011....

  14. Median nerve fascicle transfer versus ulnar nerve fascicle transfer to the biceps motor branch in C5-C6 and C5-C7 brachial plexus injuries: nonrandomized prospective study of 23 consecutive patients.

    PubMed

    Cho, Alvaro Baik; Paulos, Renata Gregorio; de Resende, Marcelo Rosa; Kiyohara, Leandro Yoshinobu; Sorrenti, Luiz; Wei, Teng Hsiang; Bolliger Neto, Raul; Mattar Júnior, Rames

    2014-10-01

    The purpose of this study was to observe whether the results of the median nerve fascicle transfer to the biceps are equivalent to the classical ulnar nerve fascicle transfer, in terms of elbow flexion strength and donor nerve morbidity. Twenty-five consecutive patients were operated between March 2007 and July 2013. The patients were divided into two groups. In Group 1 (n = 8), the patients received an ulnar nerve fascicle transfer to the biceps motor branch. In Group 2 (n = 15), the patients received a median nerve fascicle transfer to the biceps motor branch. Two patients with follow-up less than six months were excluded. Both groups were similar regarding age (P = 0.070), interval of injury (P = 0.185), and follow-up period (P = 0.477). Elbow flexion against gravity was achieved in 7 of 8 (87.5%) patients in Group 1, versus 14 of 15 (93.3%) patients in Group 2 (P = 1.000). The level of injury (C5-C6 or C5-C7) did not affect anti-gravity elbow flexion recovery in both the groups (P = 1.000). It was concluded that the median nerve fascicle transfer to the biceps is as good as the ulnar nerve fascicle transfer, even in C5-C7 injuries. PMID:24753064

  15. The self-assembly of 5,6,7-trithiapentacene-13-one molecules on gold: from low-coverage molecular chains to monolayer coverage

    NASA Astrophysics Data System (ADS)

    Larson, Amanda; Tang, Jian-Ming; Pohl, Karsten

    2015-03-01

    Understanding electronic devices down to the atomic scale is essential for the development of novel organic molecule based nanotechnologies. 5,6,7-trithiapentacene-13-one (TTPO) is a promising organic semiconductor with potential applications in high temperature photovoltaic devices. Scanning tunneling microscopy (STM) of TTPO on the close-packed stepped Au (788) surface reveals interesting nanoscale surface structures ranging from molecular chains at low coverage to an ordered self-assembled monolayer. Density functional theory (DFT) calculations have been used to further probe this unique 3-D angular assembly, where the long-axis of TTPO is parallel to the gold surface, distinctive from previously observed pentacene and pentacene derivative assemblies on surfaces. It is the lateral arrangement of the underlying pentacene backbone of the molecule that is unique, causing the thiol substituent side of the molecule to be angled down towards the gold surface, with the oxygen angled away. Combining imaging with density functional theory calculations allows for classification of these self-assembled structures with particular interest being directed toward the interaction between TTPO and gold at this organic-metallic interface. Understanding of the structure of such interfaces can potentially guide nanoscale modifications for improved electrical transport and energy-conversion efficiency in future devices.

  16. Gas-jet and tangent-slot film cooling tests of a 12.5 deg cone at Mach number of 6.7

    NASA Technical Reports Server (NTRS)

    Nowak, Robert J.

    1988-01-01

    Tests were conducted in the Langley 8-Foot High Temperature Tunnel to determine the aerothermal effects of gaseous nitrogen-coolant ejection on a 3-ft base-diameter, 12.5 degree half-angle cone. Free-stream Mach number, total temperature, and unit Reynolds number per foot were 6.7, 3300 deg R, and 1.4 million, respectively. Two coolant ejection noses were tested, an ogive frustum with a forward-facing 0.8-in radius gas-jet tip, and a 3-in radius hemisphere with a 0.243-in high rearward-facing tangent slot. Data include surface pressures and heating rates, shock shapes, and shock-layer profiles; results are compared with no-cooling data obtained with 1-in and 3-in radius solid noses. Surface pressures were reduced with gas-jet ejection but were affected little by tangent-slot ejection. For both gas-jet and tangent-slot ejection, high coolant flow rates reduced heating even far downstream from the region of ejection; however, low coolant rates caused transition to turbulence and increased heating. Shock-layer profiles of pitot pressure, Mach number, and total temperature were reduced for both gas-jet and tangent-slot ejection. Insight into the gas-jet heat-flux mechanisms was obtained by using shock-layer rake data and established, no-cooling, heat-transfer equations.

  17. Molecular cytogenetic and clinical characterization of a patient with a 5.6-Mb deletion in 7p15 including HOXA cluster.

    PubMed

    Jun, Kyung Ran; Seo, Eul-Ju; Lee, Jin-Ok; Yoo, Han-Wook; Park, In-Sook; Yoon, Hye-Kyung

    2011-03-01

    Here, we describe the clinical features of a boy with a 5.6-Mb deletion at chromosome 7p15.1-p15.3. He has mild facial anomalies, hand-foot abnormalities, hypospadias, congenital heart defects, and supernumerary nipples. This deletion was detected by array comparative genomic hybridization and verified by fluorescence in situ hybridization using BACs selected from the USCS genome browser. This deletion was not found in subsequent FISH analysis of the parental chromosomes. The deleted region contains several genes, including contiguous developmental genes on the HOXA cluster, which play a role in regulating aspects of morphogenesis during normal embryonic development. The patient's limb and urogenital features were similar to those observed in hand-foot-genital syndrome, which is caused by haploinsufficiency of HOXA13, whereas the congenital heart defect may reflect the deletion of HOXA3. We hypothesized that many clinical features of the patient were due to combined haploinsufficiency of the HOXA cluster. Our study also demonstrates the clinical usefulness of a molecular cytogenetic tool that is capable of detecting imbalances in the genome. PMID:21344639

  18. Formation of a Vitamin C Conjugate of Acrolein and its Paraoxonase-mediated Conversion into 5,6,7,8-Tetrahydroxy-4-oxooctanal

    PubMed Central

    Kesinger, Nicholas G.; Langsdorf, Brandi L.; Yokochi, Alexandre F.; Miranda, Cristobal L.; Stevens, Jan F.

    2010-01-01

    Vitamin C (ascorbic acid) has been reported to participate in Michael addition reactions in vitro to form vitamin C conjugates with α,β-unsaturated aldehydes, such as acrolein. This study shows evidence for the formation and metabolism of the vitamin C conjugate of acrolein (AscACR) in cultured human monocytic THP-1 cells exposed to acrolein diacetate. By using 18O and 13C labeling in combination with liquid chromatography–tandem mass spectrometry, AscACR was shown to undergo hydrolytic conversion of the ascorbyl lactone into an intermediate carboxylic acid. Subsequent decarboxylation of the carboxylic acid yielded 5,6,7,8-tetrahydroxy-4-oxooctanal (THO). When THP-1 cells were pretreated with ascorbic acid (1 mM, 18 hours) and then exposed to acrolein diacetate, THO was detected as its pentafluorobenzyl oxime derivative in the cell lysates and medium. Treatment of THP-1 cells with both ascorbic acid and acrolein diacetate was required for THO formation. The formation of THO from AscACR was facilitated by the lactonase enzymes, human recombinant paraoxonases 1 and 2. THP-1 cells exhibited PON activity which explains the catalytic conversion of AscACR into THO in these cells. THO was formed in addition to metabolites of the glutathione conjugate of acrolein, indicating that THO formation contributes to the elimination of acrolein in a cellular environment. PMID:20353174

  19. Heterogeneous expression of HLA-G1, -G2, -G5, -G6, and -G7 in myeloid and plasmacytoid dendritic cells isolated from umbilical cord blood.

    PubMed

    Román, Angela; Rodríguez, Miriam; Herraiz, Miguel A; Jordá, Julia; Cervera, Isabel; Peñaloza, Jorge; Vidart, Jose A; Martinez-Laso, Jorge

    2009-02-01

    Human leukocyte antigen (HLA)-G is a human nonclassic major histocompatibility complex (MHC) molecule characterized by a limited polymorphism and a low, restricted cell surface expression. HLA-G is constitutively expressed on trophoblasts, fetal endothelial, and epithelial cells, conferring alloimmune protection during pregnancy. HLA-G is also expressed in some malignancies and on macrophages and dendritic cells (DC) in tumoral and inflammatory diseases. Because DC constitute an important component in the immune response and umbilical cord blood has a different immune behavior than peripheral blood, the HLA-G protein profile and mRNA expression were investigated on the different DC subsets present in cord blood. Surface and intracellular expression have been reported on DC and HLA-G1, -G2, -G5, -G6, and -G7 transcripts were present. Different levels of soluble HLA-G were obtained from serum and correlated with gene expression. These data are in contrast with the data previously described for adult peripheral blood, where a limited pattern of HLA-G transcripts was reported; only in the maturation process were more isoforms present. These results demonstrate that DC from cord blood have a different behavior than DC in peripheral blood and could be in accordance with the results obtained in cord blood transplantation, where a lesser effect of graft-versus-host disease exists than in bone marrow transplantation. PMID:19135113

  20. Comparison of Values in 5th, 6th, 7th and 8th Grade Primary Education Music Class Students'? Workbooks According to Rokeach?s and Akbas's Value Classifications

    ERIC Educational Resources Information Center

    Çakirer, H. Serdar

    2014-01-01

    The aim of the present study is to compare the values in the songs of 5th, 6th, 7th and 8th grade primary education music classes students? workbooks according to the value categorizations proposed by Rockeach and Akbas and which values among the categories mentioned are taught to the students in the 5th, 6th, 7th and 8th grade primary education…

  1. Second order phase transition temperature of single crystals of Gd5Si1.3Ge2.7 and Gd5Si1.4Ge2.6

    DOE PAGESBeta

    Hadimani, R. L.; Melikhov, Y.; Schlagel, D. L.; Lograsso, T. A.; Dennis, K. W.; McCallum, R. W.; Jiles, D. C.

    2015-01-30

    Gd5(SixGe1–x)4 has mixed phases in the composition range 0.32 < x < 0.41, which have not been widely studied. In this paper, we have synthesized and indexed single crystal samples of Gd5Si1.3Ge2.7 and Gd5Si1.4Ge2.6. In this study, we have investigated the first order and second order phase transition temperatures of these samples using magnetic moment vs. temperature and magnetic moment vs. magnetic field at different temperatures. We have used a modified Arrott plot technique that was developed and reported by us previously to determine the “hidden” second order phase transition temperature of the orthorhombic II phase.

  2. 3,3,6,6-Tetra­methyl-9-[6-(3,3,6,6-tetra­methyl-1,8-dioxo-2,3,4,5,6,7,8,9-octa­hydro-1H-xanthen-9-yl)pyridin-2-yl]-2,3,4,5,6,7,8,9-octa­hydro-1H-xanthene-1,8-dione

    PubMed Central

    Abdelhamid, Antar A.; Mohamed, Shaaban Kamel; Allahverdiyev, Mirze A.; Gurbanov, Atash V.; Ng, Seik Weng

    2011-01-01

    In the title mol­ecule, C39H45NO6, the two tetra­methyl­octa­hydroxanthen-1,8-dione substituents are arranged approximately parallel to each other and approximately perpendicular to the plane of the pyridine ring. The six-membered xanthene rings adopt flattened boat conformations with the O and methine C atoms deviating from the plane of the other four atoms. PMID:21754076

  3. Spectroscopic and thermal studies on charge-transfer complexes of perhydroisoquinoline with p-chloranil, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, and 7,7',8,8'-tetracyanoquinodimethane

    NASA Astrophysics Data System (ADS)

    Refat, Moamen S.; Abou-Melha, Sraa

    2012-03-01

    Charge-transfer interactions of perhydroisoquinoline (PHIQ) with 2,3-dichloro-5,6-dicyano-1,4- benzoquinone (DDQ), p-chloranil (CHL), and 7,7',8,8'-tetracyanoquinodimethane (TCNQ) in chloroform as a solvent have resulted in stable complexes with a general formula [(PHIQ)(acceptor)] with a molar ratio of 1:1 (donor:acceptor). Elemental (C, H, N) and thermogravimetric (TGA/DTG) analyses, photometric titration, and electronic, infrared, and 1H NMR spectra were used to give an idea of the charge-transfer interaction between donating and accepting sites. The Benesi-Hildebrand method and its modification were used to determine an association constant (K) and a molar extinction coefficient (ɛ).

  4. Quantum-chemical insight into structure-reactivity relationship in 4,5,6,7-tetrahalogeno-1H-benzimidazoles: a combined X-ray, DSC, DFT/QTAIM, Hirshfeld surface-based, and molecular docking approach.

    PubMed

    Latosińska, Jolanta Natalia; Latosińska, Magdalena; Maurin, Jan Krzysztof; Orzeszko, Andrzej; Kazimierczuk, Zygmunt

    2014-03-20

    The weak interaction patterns in 4,5,6,7-tetrahalogeno-1H-benzimidazoles, protein kinase CK2 inhibitors, in solid state are studied by the X-ray method and quantum chemistry calculations. The crystal structures of 4,5,6,7-tetrachloro- and 4,5,6,7-tetrabromo-1H-benzimidazole are determined by X-ray diffraction and refined to a final R-factor of 3.07 and 3.03%, respectively, at room temperature. The compound 4,5,6,7-tetrabromo-1H-benzimidazole, which crystallizes in the I41/a space group, is found to be isostructural with previously studied 4,5,6,7-tetraiodo-1H-benzimidazole in contrast to 4,5,6,7-tetrachloro-1H-benzimidazole, which crystallizes as triclinic P1̅ with 4 molecules in elementary unit. For 4,5,6,7-tetrachloro-1H-benzimidazole, differential scanning calorimetry (DSC) revealed a second order glassy phase transition at Tg = 95°/106° (heating/cooling), an indication of frozen disorder. The lack of 3D isostructurality found in all 4,5,6,7-tetrahalogeno-1H-benzimidazoles is elucidated on the basis of the intra- and intermolecular interactions (hydrogen bonding, van der Waals contacts, and C-H···π interactions). The topological Bader's Quantum Theory of Atoms in Molecules (QTAIM) and Spackman's Hirshfeld surface-based approaches reveal equilibration of electrostatic matching and dispersion van der Waals interactions between molecules consistent with the crystal site-symmetry. The weakening of van der Waals forces accompanied by increasing strength of the hydrogen bond (N-H···N) result in a decrease in the crystal site-symmetry and a change in molecular packing in the crystalline state. Crystal packing motifs were investigated with the aid of Hirshfeld surface fingerprint plots. The ordering 4,5,6,7-tetraiodo > 4,5,6,7-tetrabromo > 4,5,6,7-tetrachloro > 4,5,6,7-tetrafluoro reflects not only a decrease in crystal symmetry but also increase in chemical reactivity (electronic activation), which could explain some changes in biological activity of

  5. A facile environment-friendly one-pot two-step regioselective synthetic strategy for 3,7-diarylpyrazolo[1,5-a]pyrimidines related to zaleplon and 3,6-diarylpyrazolo[1,5-a]pyrimidine-7-amines assisted by KHSO[Formula: see text] in aqueous media.

    PubMed

    Devi, Asem Satyapati; Kaping, Shunan; Vishwakarma, Jai Narain

    2015-11-01

    3-Aminopyrazoles required for the synthesis of pyrazolo[1,5-a]pyrimidines were obtained by the reaction of enaminonitriles with hydrazine hydrate. The resulting aminopyrazoles are reacted with formylated acetophenones under reflux at [Formula: see text] assisted by KHSO[Formula: see text] in aqueous media to form regioselectively 3,7-diarylpyrazolo[1,5-a]pyrimidines and 3,6-diarylpyrazolo[1,5-a]pyrimidine-7-amines. X-ray crystallography of selected compounds 5b and 7i further confirmed the regioselective formation of these products. PMID:26016724

  6. 38 CFR 7.6 - Benefits.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Benefits. 7.6 Section 7.6... Soldiers' and Sailors' Civil Relief Act Amendments of 1942 § 7.6 Benefits. Any policy found to be entitled... such monetary benefits arising out of the contract or by reason thereof, will be held subject...

  7. 22 CFR 19.6-7 - Decision.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... FOREIGN SERVICE RETIREMENT AND DISABILITY SYSTEM § 19.6-7 Decision. (a) When a response has not been... the court order or divorce decree, and the record contains support for the objection, PER/ER/RET will... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Decision. 19.6-7 Section 19.6-7...

  8. 22 CFR 19.6-7 - Decision.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... FOREIGN SERVICE RETIREMENT AND DISABILITY SYSTEM § 19.6-7 Decision. (a) When a response has not been... the court order or divorce decree, and the record contains support for the objection, PER/ER/RET will... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Decision. 19.6-7 Section 19.6-7...

  9. 22 CFR 19.6-7 - Decision.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... FOREIGN SERVICE RETIREMENT AND DISABILITY SYSTEM § 19.6-7 Decision. (a) When a response has not been... the court order or divorce decree, and the record contains support for the objection, PER/ER/RET will... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Decision. 19.6-7 Section 19.6-7...

  10. 22 CFR 19.6-7 - Decision.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... FOREIGN SERVICE RETIREMENT AND DISABILITY SYSTEM § 19.6-7 Decision. (a) When a response has not been... the court order or divorce decree, and the record contains support for the objection, PER/ER/RET will... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Decision. 19.6-7 Section 19.6-7...

  11. 39 CFR 6.7 - Notation voting.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Notation voting. 6.7 Section 6.7 Postal Service UNITED STATES POSTAL SERVICE THE BOARD OF GOVERNORS OF THE U.S. POSTAL SERVICE MEETINGS (ARTICLE VI) § 6.7 Notation voting. (a) General. Notation voting consists of the circulation of written memoranda...

  12. 39 CFR 6.7 - Notation voting.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Notation voting. 6.7 Section 6.7 Postal Service UNITED STATES POSTAL SERVICE THE BOARD OF GOVERNORS OF THE U.S. POSTAL SERVICE MEETINGS (ARTICLE VI) § 6.7 Notation voting. (a) General. Notation voting consists of the circulation of written memoranda...

  13. 39 CFR 6.7 - Notation voting.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Notation voting. 6.7 Section 6.7 Postal Service UNITED STATES POSTAL SERVICE THE BOARD OF GOVERNORS OF THE U.S. POSTAL SERVICE MEETINGS (ARTICLE VI) § 6.7 Notation voting. (a) General. Notation voting consists of the circulation of written memoranda...

  14. 38 CFR 7.6 - Benefits.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Benefits. 7.6 Section 7.6... Soldiers' and Sailors' Civil Relief Act Amendments of 1942 § 7.6 Benefits. Any policy found to be entitled... such monetary benefits arising out of the contract or by reason thereof, will be held subject...

  15. 38 CFR 7.6 - Benefits.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false Benefits. 7.6 Section 7.6... Soldiers' and Sailors' Civil Relief Act Amendments of 1942 § 7.6 Benefits. Any policy found to be entitled... such monetary benefits arising out of the contract or by reason thereof, will be held subject...

  16. 38 CFR 7.6 - Benefits.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false Benefits. 7.6 Section 7.6... Soldiers' and Sailors' Civil Relief Act Amendments of 1942 § 7.6 Benefits. Any policy found to be entitled... such monetary benefits arising out of the contract or by reason thereof, will be held subject...

  17. 38 CFR 7.6 - Benefits.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2012-07-01 2012-07-01 false Benefits. 7.6 Section 7.6... Soldiers' and Sailors' Civil Relief Act Amendments of 1942 § 7.6 Benefits. Any policy found to be entitled... such monetary benefits arising out of the contract or by reason thereof, will be held subject...

  18. 22 CFR 19.6-7 - Decision.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Decision. 19.6-7 Section 19.6-7 Foreign... FOREIGN SERVICE RETIREMENT AND DISABILITY SYSTEM § 19.6-7 Decision. (a) When a response has not been..., PER/ER/RET will advise both parties of the basis for its decision and the alternative action, if...

  19. Synthesis of 4-((1E, 6E)-7-(4-hydroxy-3-methoxyphenyl)-3, 5-dioxohepta-1, 6-dienyl)-2-methoxyphenyl 4-fluorobenzoate, a novel monoester derivative of curcumin, its experimental and theoretical (DFT) studies

    NASA Astrophysics Data System (ADS)

    Srivastava, Sangeeta; Gupta, Preeti; Amandeep; Singh, Ranvijay Pratap

    2016-04-01

    Curcumin (1), isolated as a major component from the chloroform extract of Curcuma longa was converted to its ester derivative 4-((1E, 6E)-7-(4-hydroxy-3-methoxyphenyl)-3,5-dioxohepta-1,6-dienyl)-2-methoxyphenyl 4-fluorobenzoate (2). The compound has been characterized with the help of 1H, 13C NMR, UV, IR and mass spectrometry. The molecular geometry of synthesized compound was calculated in ground state by Density functional theory (DFT/B3LYP) using 6-31G (d,p) basis set. 1H and 13C NMR chemical shifts were calculated in ground state by using Gauge-Including Atomic Orbital (GIAO) approach and these values were correlated with experimental observations. The electronic properties such as HOMO and LUMO energies were calculated using time dependent Density Functional Theory (TD-DFT). Stability of the molecule as a result of hyper conjugative interactions and electron delocalization were analysed using Natural bond orbital (NBO) analysis. Intramolecular interactions were analysed by AIM (Atom in molecule) approach. Global reactivity descriptors were calculated to study the reactive site within molecule. The vibrational wavenumbers were calculated using DFT method and assigned with the help of potential energy distribution (PED). First hyperpolarizability values have been calculated to describe the nonlinear optical (NLO) property of the synthesized compounds. Molecular electrostatic potential (MEP) analysis has also been carried out.

  20. 7 CFR 624.5 - Coordination.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Coordination. 624.5 Section 624.5 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF... Presidentially-declared natural disasters. (b) When an NRCS State Conservationist determines that a...

  1. 7 CFR 610.5 - Interdisciplinary assistance.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Interdisciplinary assistance. 610.5 Section 610.5 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE... Interdisciplinary assistance. Technical assistance is based on the principle that soil, water, plant, and...

  2. 7 CFR 610.5 - Interdisciplinary assistance.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Interdisciplinary assistance. 610.5 Section 610.5 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE... Interdisciplinary assistance. Technical assistance is based on the principle that soil, water, plant, and...

  3. 7 CFR 633.5 - Application procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Application procedures. 633.5 Section 633.5 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE... to protect the wetland, and provides essential habitat for the nesting, breeding or feeding...

  4. 7 CFR 625.5 - Application procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Application procedures. 625.5 Section 625.5 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE... selection. Upon selection for funding, the State Conservationist will issue a public sign-up notice...

  5. 7 CFR 625.5 - Application procedures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Application procedures. 625.5 Section 625.5 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE... selection. Upon selection for funding, the State Conservationist will issue a public sign-up notice...

  6. 7 CFR 625.5 - Application procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Application procedures. 625.5 Section 625.5 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE... selection. Upon selection for funding, the State Conservationist will issue a public sign-up notice...

  7. 7 CFR 625.5 - Application procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Application procedures. 625.5 Section 625.5 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE... selection. Upon selection for funding, the State Conservationist will issue a public sign-up notice...

  8. The attack of titanium-6 wt% aluminium-4 wt% vanadium alloy by a molten uranium-5.7 wt% manganese alloy at 1015 °C

    NASA Astrophysics Data System (ADS)

    Moran, F. J.; Jarman, R. A.

    1991-06-01

    The liquid metal corrosion (LMC) resistance of the alloy Ti-6 wt% Al-4 wt% V (IMI 318) in contact with molten U-5.7 wt% Mn has been assessed. The uranium alloy was melted at 1015 °C under vacuum in hemispherical IMI 318 alloy crucibles. The attack rate of the molten alloy on the IMI 318, for times up to 3 h, was estimated from metallography and by chemical analysis of the resolidified uranium melt. The mechanism of the LMC process was examined with optical and electron microscopy allied with EDAX and microhardness tests. Melt saturation occurred after one hour and titanium-rich (approximately 80 wt% Ti) dendrites began to nucleate and grow in the uranium melt. This result was predicted by the relevant equilibrium phase diagrams. During the LMC reaction, an interface (diffusion) layer grew in IMI 318 alloy where it contacted the uranium alloy melt. The levels of Ti and U changed with test time and distance across this interface, with the Ti level falling at the melt/IMI 318 surface and the U increasing at the same point. The mean LMC rate was initially rapid, 1.45 mm/h after 15 min but fell to 0.3 mm/h at 3 h. The conclusions were that the LMC reaction was diffusion-controlled, with the slow self-diffusion of β-titanium most likely to be the rate determining step. The reaction probably follows parabolic rate-kinetics as do other diffusion-controlled processes. The attack front was generally uniform with no clear evidence of preferential attack.

  9. High-Resolution Locations and Focal Mechanisms of Aftershocks of the September 5, 2012 Mw=7.6 Nicoya, Costa Rica Earthquake

    NASA Astrophysics Data System (ADS)

    Laure, Duboeuf; Susan, Schwartz

    2015-04-01

    Subduction beneath the Nicoya Peninsula, Costa Rica generates the largest underthrusting earthquakes in the country with a recurrence interval of about 50 years. The most recent of these events occurred on September 5th 2012 (Mw 7.6). A vigorous aftershock sequence of more than 6400 earthquakes was recorded by a local seismic network within the first 4 months of the mainshock. We identify those aftershocks occurring on the mainshock fault plane and compare their locations to the 2012 mainshock slip distribution, the location of past interplate seismicity, and slow slip phenomena to better understand the mechanical behavior of this plate interface. Our focal mechanism determination includes all aftershocks occurring within the first nine days after the mainshock and aftershocks with magnitude greater than four occurring through the end of December 2012. We use the HASH (Hardebeck and Shearer, 2002) software package, based on first motion polarities, to obtain aftershock focal mechanisms. We are able to determine reliable focal mechanisms for 583 of the aftershocks and identify 264 of them as occurring on the plate interface. All of these are relocated using HypoDD (Waldhauser and Ellsworth, 2000) and their locations are compared with other plate boundary activity. We find no significant seismicity patterns as a function of time or magnitude, but confirm that deeper underthrusting events occur in the north compared to the south as revealed by previous studies (Newman et al., 2002). Most of the aftershocks occur in and around the updip part of the coseismic rupture zone. This suggests that the Nicoya mainshock released all of the accumulated strain in the deeper part of the plate interface, leaving none to occur as aftershocks. Previous interface seismicity in this region reveals a similar distribution to the aftershocks, however it extends to deeper depth and defines the entire seismogenic zone. The coseismic slip occurs even deeper than the background interface

  10. 40 CFR 721.10268 - [5,6]Fullerene-C70-D5h(6).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Substances § 721.10268 Fullerene-C70-D5h(6). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as Fullerene-C70-D5h(6) (PMN P-09-55; CAS No. 115383-22-7...) of this section. The requirements of this rule do not apply to quantities of the PMN substance...

  11. 2-(3-Benzoylthioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ameliorates metabolic disorders in high-fat diet-fed mice

    PubMed Central

    Zhang, Jin; Zhang, Li-na; Chen, Dong-mei; Fu, Yan-yun; Zhang, Feng; Yang, Ling-ling; Xia, Chun-mei; Jiang, Hao-wen; Tang, Chun-lan; Xie, Zhi-fu; Yang, Fan; Li, Jia; Tang, Jie; Li, Jing-ya

    2015-01-01

    Aim: Sterol-regulatory element binding proteins (SREBPs) are major transcription factors that regulate liver lipid biosynthesis. In this article we reported a novel synthetic compound 2-(3-benzoylthioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid (ZJ001) that inhibited the SREBP-1c pathway, and effectively reduced hepatic lipid accumulation in diet-induced obesity (DIO) mice. Methods: A luciferase reporter driven by an SRE-containing promoter transfected into HepG2 cells was used to discover the compound. Two approaches were used to evaluate the lipid-lowering effects of ZJ001: (1) diet-induced obesity (DIO) mice that were treated with ZJ001 (15 mg·kg−1·d−1, po) for 7 weeks; and (2) HepG2 cells and primary hepatocytes used as in vitro models. Results: ZJ001 (10, 20 μmol/L) dose-dependently inhibited the activity of SRE-containing promoter. ZJ001 administration ameliorated lipid metabolism and improved glucose tolerance in DIO mice, accompanied by significantly reduced mRNA levels of SREBP-1C and SREBP-2, and their downstream genes. In HepG2 cells and insulin-treated hepatocytes, ZJ001 (10–40 μmol/L) dose-dependently inhibited lipid synthesis, and reduced mRNA levels of SREBP-1C and SREBP-2, and their downstream genes. Furthermore, ZJ001 dose-dependently increased the phosphorylation of AMPK and regulatory-associated protein of mTOR (Raptor), and suppressed the phosphorylation of mTOR in insulin-treated hepatocytes. Moreover, ZJ001 increased the ADP/ATP ratio in insulin-treated hepatocytes. Conclusion: ZJ001 exerts multiple beneficial effects in diet-induced obesity mice. Its lipid-lowering effects may result from the suppression of mTORC1, which regulates SREBP-1c transcription. The results suggest that the SREBP-1c pathway may be a potential therapeutic target for the treatment of lipid metabolic disorders. PMID:25832429

  12. 7 CFR 1720.6 - Application process.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... pursuant to 7 CFR 1720.7(a) of this part, to ascertain its threshold eligibility for the program; (3) RUS evaluates the application pursuant to the selection criteria set forth in 7 CFR 1720.7(b) of this part; (4... 7 Agriculture 11 2010-01-01 2010-01-01 false Application process. 1720.6 Section...

  13. 7 CFR 1720.6 - Application process.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... application to the Secretary; (2) The application is screened by RUS pursuant to 7 CFR 1720.7(a) of this part... the selection criteria set forth in 7 CFR 1720.7(b) of this part; (4) If RUS provisionally approves... 7 Agriculture 11 2014-01-01 2014-01-01 false Application process. 1720.6 Section...

  14. 6 CFR 5.6 - Responses to requests.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 6 Domestic Security 1 2014-01-01 2014-01-01 false Responses to requests. 5.6 Section 5.6 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY DISCLOSURE OF RECORDS AND INFORMATION Freedom of Information Act § 5.6 Responses to requests. (a) Acknowledgements of requests. On receipt of a request, a component ordinarily...

  15. 16. A southward view of buildings #6B, #6, #6A, #7, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. A southward view of buildings #6-B, #6, #6-A, #7, #8-A, and #8. The water tower is situated directly behind building #8. To the right ia the eastern wall of the five-storied building #5. In the center background is part of the north face of building #9. All structures to the north of building #9 are to be demolished. - American Chain & Cable Company, East Princess Street (400 Block), York, York County, PA

  16. Synthesis of 3,8-Dichloro-6-ethyl-1,2,5,7-tetramethyl–BODIPY from an Asymmetric Dipyrroketone and Reactivity Studies at the 3,5,8-Positions**

    PubMed Central

    Zhao, Ning; Fronczek, Frank R.; Smith, Kevin M.

    2015-01-01

    The asymmetric BODIPY 1a (BODIPY=4,4-difluoro-4-bora-3a,4a-diaza-s-indacene), containing two chloro substituents at the 3,8-positions and a reactive 5-methyl group, was synthesized from the asymmetric dipyrroketone 3, which was readily obtained from available pyrrole 2a. The reactivity of 3,8-dichloro-6-ethyl-1,2,5,7-tetramethyl-BODIPY 1a was investigated by using four types of reactions. This versatile BODIPY undergoes regioselective Pd0-catalyzed Stille coupling reactions and/or regioselective nucleophilic addition/elimination reactions, first at the 8-chloro and then at the 3-chloro group, using a variety of organostannanes and N-, O-, and S-centered nucleophiles. On the other hand, the more reactive 5-methyl group undergoes regioselective Knoevenagel condensation with an aryl aldehyde to produce a monostyryl-BODIPY, and oxidation with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) gives the corresponding 5-formyl-BODIPY. Investigation of the reactivity of asymmetric BODIPY 1a led to the preparation of a variety of functionalized BODIPYs with λmax of absorption and emission in the ranges 487–587 and 521–617 nm, respectively. The longest absorbing/emitting compound was the monostyryl-BODIPY 16, and the largest Stokes shift (49 nm) and fluorescence quantum yield (0.94) were measured for 5-thienyl-8-phenoxy-BODIPY 15. The structural properties (including 16 X-ray structures) of the new series of BODIPYs were investigated. PMID:25761150

  17. (2aR*,5S*,6aS*,8aS*,E)-Ethyl 5-hy­droxy-7,7,8a-trimethyl-8-oxo-2,2a,6,6a,7,8,8a,8b-octa­hydro-1H-penta­leno[1,6-bc]oxepine-4-carboxyl­ate

    PubMed Central

    Mehta, Goverdhan; Kumar, C. S. Ananda; Sen, Saikat

    2012-01-01

    The title compound, C17H24O5, featuring a 2-carbeth­oxy-3-oxepanone unit in its intra­molecularly O—H⋯O hydrogen-bonded enol form, was obtained via [(CF3CO2)2Rh]2-catal­ysed intra­molecular O—H bond insertion in the α-diazo-ω-hy­droxy-β-ketoester, ethyl 4-[(1S,3aS,6R,6aS)-6-hy­droxy-2,2,3a-trimethyl-3-oxo-octa­hydro­penta­len-1-yl]-2-diazo-3-oxobutano­ate. The seven-membered oxacyclic ring, thus constructed on a cis-fused diquinane platform, was found to adopt a distorted boat–sofa conformation. PMID:23476221

  18. 5-Bromo (or chloro)-6-azido-5,6-dihydro-2' -deoxyuridine and -thymidine derivatives with potent antiviral activity.

    PubMed

    Kumar, Rakesh

    2002-02-11

    Synthesis, antiviral, and cytotoxic activities of 5-bromo (or chloro)-6-azido-5,6-dihydro-2' -deoxyuridine (4,5) and -thymidine (6,7) are reported. Compounds 4 and 5 exhibited a broad spectrum of antiherpes activity against (HSV-1, HSV-2, HCMV, and VZV). PMID:11814776

  19. 5 CFR 6.6 - Revocation of exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Revocation of exceptions. 6.6 Section 6.6 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES EXCEPTIONS FROM THE COMPETITIVE SERVICE (RULE VI) § 6.6 Revocation of exceptions. OPM may remove any position from or may revoke in whole or in part any provision...

  20. 7 CFR 718.6 - Controlled substance.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 7 2012-01-01 2012-01-01 false Controlled substance. 718.6 Section 718.6 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE FARM... General Provisions § 718.6 Controlled substance. (a) The following terms apply to this section: (1)...

  1. 7 CFR 718.6 - Controlled substance.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Controlled substance. 718.6 Section 718.6 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE FARM... General Provisions § 718.6 Controlled substance. (a) The following terms apply to this section: (1)...

  2. 7 CFR 718.6 - Controlled substance.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 7 2014-01-01 2014-01-01 false Controlled substance. 718.6 Section 718.6 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE FARM... General Provisions § 718.6 Controlled substance. (a) The following terms apply to this section: (1)...

  3. 7 CFR 771.6 - Environmental requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 7 2012-01-01 2012-01-01 false Environmental requirements. 771.6 Section 771.6... AGRICULTURE SPECIAL PROGRAMS BOLL WEEVIL ERADICATION LOAN PROGRAM § 771.6 Environmental requirements. No loan will be made until all Federal and state statutory and regulatory environmental requirements have...

  4. 7 CFR 771.6 - Environmental requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 7 2014-01-01 2014-01-01 false Environmental requirements. 771.6 Section 771.6... AGRICULTURE SPECIAL PROGRAMS BOLL WEEVIL ERADICATION LOAN PROGRAM § 771.6 Environmental requirements. No loan will be made until all Federal and state statutory and regulatory environmental requirements have...

  5. 7 CFR 1957.6 - Appeal reviews.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., DC, under the FmHA or its successor agency under Public Law 103-354 Appeal Procedures, 7 CFR part... 7 Agriculture 14 2011-01-01 2011-01-01 false Appeal reviews. 1957.6 Section 1957.6 Agriculture... REGULATIONS (CONTINUED) ASSET SALES Rural Housing Asset Sales § 1957.6 Appeal reviews. The Master...

  6. 7 CFR 1957.6 - Appeal reviews.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., DC, under the FmHA or its successor agency under Public Law 103-354 Appeal Procedures, 7 CFR part... 7 Agriculture 14 2014-01-01 2014-01-01 false Appeal reviews. 1957.6 Section 1957.6 Agriculture... REGULATIONS (CONTINUED) ASSET SALES Rural Housing Asset Sales § 1957.6 Appeal reviews. The Master...

  7. 7 CFR 622.6 - Equal opportunity.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... of Agriculture (7 CFR Part 15), which provide that no person in the United States shall, on the... 7 Agriculture 6 2010-01-01 2010-01-01 false Equal opportunity. 622.6 Section 622.6 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT...

  8. 7 CFR 771.6 - Environmental requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Environmental requirements. 771.6 Section 771.6... AGRICULTURE SPECIAL PROGRAMS BOLL WEEVIL ERADICATION LOAN PROGRAM § 771.6 Environmental requirements. No loan will be made until all Federal and state statutory and regulatory environmental requirements have...

  9. 7 CFR 771.6 - Environmental requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 7 2011-01-01 2011-01-01 false Environmental requirements. 771.6 Section 771.6... AGRICULTURE SPECIAL PROGRAMS BOLL WEEVIL ERADICATION LOAN PROGRAM § 771.6 Environmental requirements. No loan will be made until all Federal and state statutory and regulatory environmental requirements have...

  10. 7 CFR 1499.6 - Payments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Payments. 1499.6 Section 1499.6 Agriculture... AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS FOOD FOR PROGRESS PROGRAM § 1499.6 Payments. (a) If the participant arranges for transportation in accordance with § 1499.7(b)(2), and the participant seeks...

  11. 7 CFR 1499.6 - Payments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Payments. 1499.6 Section 1499.6 Agriculture... AGRICULTURE EXPORT PROGRAMS FOOD FOR PROGRESS PROGRAM § 1499.6 Payments. (a) If the participant arranges for transportation in accordance with § 1499.7(b)(2), and the participant seeks payment directly, the...

  12. 7 CFR 1499.6 - Payments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Payments. 1499.6 Section 1499.6 Agriculture... AGRICULTURE EXPORT PROGRAMS FOOD FOR PROGRESS PROGRAM § 1499.6 Payments. (a) If the participant arranges for transportation in accordance with § 1499.7(b)(2), and the participant seeks payment directly, the...

  13. 7 CFR 650.6 - Categorical exclusions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    .... These are data gathering and interpretation programs and include: (1) Soil Survey—7 CFR part 611; (2) Snow Survey and Water Supply Forecasts—7 CFR part 612; (3) Plant Materials for Conservation—7 CFR part... Studies under section 6 of Pub. L. 83-566 as amended—7 CFR part 621. (b) When any new action is...

  14. 7 CFR 650.6 - Categorical exclusions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    .... These are data gathering and interpretation programs and include: (1) Soil Survey—7 CFR part 611; (2) Snow Survey and Water Supply Forecasts—7 CFR part 612; (3) Plant Materials for Conservation—7 CFR part... Studies under section 6 of Pub. L. 83-566 as amended—7 CFR part 621. (b) When any new action is...

  15. 7 CFR 650.6 - Categorical exclusions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    .... These are data gathering and interpretation programs and include: (1) Soil Survey—7 CFR part 611; (2) Snow Survey and Water Supply Forecasts—7 CFR part 612; (3) Plant Materials for Conservation—7 CFR part... Studies under section 6 of Pub. L. 83-566 as amended—7 CFR part 621. (b) When any new action is...

  16. The fifth spectrum of platinum (Pt V): Analysis of the (5d6 + 5d5 6 s) - 5d5 6 p transition array

    NASA Astrophysics Data System (ADS)

    Azarov, Vladimir I.; Gayasov, Robert R.

    2016-03-01

    The spectrum of platinum was observed in the 300-2100 Å wavelength region. The (5d6 + 5d5 6 s) - 5d5 6 p transition array of four times ionized platinum, Pt V, has been investigated and 1659 spectral lines have been classified in the region of 460-1730 Å. The analysis has led to the determination of the 5d6, 5d5 6 s and 5d5 6 p configurations. Thirty two of 34 theoretically possible 5d6 levels, 45 of 74 possible 5d5 6 s levels and 181 of 214 possible 5d5 6 p levels have been established. The orthogonal operators technique was used to calculate the level structure and transition probabilities. The energy parameters have been determined by the least squares fit to the observed levels. Calculated transition probability and energy values, as well as LS-compositions obtained from the fitted parameters are presented.

  17. Vasorelaxant and antiplatelet activity of 4,7-dimethyl-1,2, 5-oxadiazolo[3,4-d]pyridazine 1,5,6-trioxide: role of soluble guanylate cyclase, nitric oxide and thiols.

    PubMed

    Kots, A Y; Grafov, M A; Khropov, Y V; Betin, V L; Belushkina, N N; Busygina, O G; Yazykova, M Y; Ovchinnikov, I V; Kulikov, A S; Makhova, N N; Medvedeva, N A; Bulargina, T V; Severina, I S

    2000-03-01

    1. Certain heterocyclic N-oxides are vasodilators and inhibitors of platelet aggregation. The pharmacological activity of the furoxan derivative condensed with pyridazine di-N-oxide 4,7-dimethyl-1,2, 5-oxadiazolo[3,4-d]pyridazine 1,5,6-trioxide (FPTO) and the corresponding furazan (FPDO) was studied. 2. FPTO reacted with thiols generating nitrite (NO), S-nitrosoglutathione and hydroxylamine (nitroxyl) and converted oxyHb to metHb. FPDO did not generate detectable amounts of NO-like species but reacted with thiols and oxyHb. 3. FPTO and FPDO haem-dependently stimulated the activity of soluble guanylate cyclase (sGC) and this stimulation was inhibited by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) and by 0.1 mM dithiothreitol. 4. FPTO relaxed noradrenaline-precontracted aortic rings and its concentration-response curve was biphasic (pIC(50)=9. 03+/-0.13 and 5.85+/-0.06). FPDO was significantly less potent vasodilator (pIC(50)=5.19+/-0.14). The vasorelaxant activity of FPTO and FPDO was inhibited by ODQ. oxyHb significantly inhibited only FPTO-dependent relaxation. 5. FPTO and FPDO were equipotent inhibitors of ADP-induced platelet aggregation (IC(50)=0.63+/-0.15 and 0.49+/-0. 05 microM, respectively). The antiplatelet activity of FPTO (but not FPDO) was partially suppressed by oxyHb. The antiaggregatory effects of FPTO and FPDO were only partially blocked by sGC inhibitors. 6. FPTO and FPDO (10 - 20 microM) significantly increased cyclic GMP levels in aortic rings and platelets and this increase was blocked by ODQ. 7. Thus, FPTO can generate NO and, like FPDO, reacts with thiols and haem. The vasorelaxant activity of FPTO and FPDO is sGC-dependent and a predominant role is played by NO at FPTO concentrations below 1 microM. On the contrary, inhibition of platelet aggregation is only partially related to sGC activation. PMID:10725265

  18. 7 CFR 501.6 - Gambling.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Gambling. 501.6 Section 501.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.6 Gambling. Participating...

  19. 7 CFR 501.6 - Gambling.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Gambling. 501.6 Section 501.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.6 Gambling. Participating...

  20. 7 CFR 501.6 - Gambling.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Gambling. 501.6 Section 501.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.6 Gambling. Participating...

  1. 7 CFR 501.6 - Gambling.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Gambling. 501.6 Section 501.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.6 Gambling. Participating...

  2. 7 CFR 501.6 - Gambling.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Gambling. 501.6 Section 501.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.6 Gambling. Participating...

  3. 7 CFR 1126.6 - Supply plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Supply plant. 1126.6 Section 1126.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1126.6 Supply plant. See § 1000.6....

  4. 7 CFR 1033.6 - Supply plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Supply plant. 1033.6 Section 1033.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1033.6 Supply plant. See § 1000.6....

  5. 7 CFR 1007.6 - Supply plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Supply plant. 1007.6 Section 1007.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1007.6 Supply plant. See § 1000.6....

  6. 7 CFR 1006.6 - Supply plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Supply plant. 1006.6 Section 1006.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1006.6 Supply plant. See § 1000.6....

  7. 7 CFR 1124.6 - Supply plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Supply plant. 1124.6 Section 1124.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Regulating Handling Definitions § 1124.6 Supply plant. See § 1000.6....

  8. 7 CFR 1033.6 - Supply plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Supply plant. 1033.6 Section 1033.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1033.6 Supply plant. See § 1000.6....

  9. 7 CFR 1131.6 - Supply plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Supply plant. 1131.6 Section 1131.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1131.6 Supply plant. See § 1000.6....

  10. 7 CFR 1006.6 - Supply plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Supply plant. 1006.6 Section 1006.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1006.6 Supply plant. See § 1000.6....

  11. 7 CFR 1005.6 - Supply plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Supply plant. 1005.6 Section 1005.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1005.6 Supply plant. See § 1000.6....

  12. 7 CFR 1006.6 - Supply plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Supply plant. 1006.6 Section 1006.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1006.6 Supply plant. See § 1000.6....

  13. 7 CFR 1131.6 - Supply plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Supply plant. 1131.6 Section 1131.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1131.6 Supply plant. See § 1000.6....

  14. 7 CFR 1007.6 - Supply plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Supply plant. 1007.6 Section 1007.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1007.6 Supply plant. See § 1000.6....

  15. 7 CFR 1006.6 - Supply plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Supply plant. 1006.6 Section 1006.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1006.6 Supply plant. See § 1000.6....

  16. 7 CFR 1032.6 - Supply plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Supply plant. 1032.6 Section 1032.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1032.6 Supply plant. See § 1000.6....

  17. 7 CFR 1124.6 - Supply plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Supply plant. 1124.6 Section 1124.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Regulating Handling Definitions § 1124.6 Supply plant. See § 1000.6....

  18. 7 CFR 1005.6 - Supply plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Supply plant. 1005.6 Section 1005.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1005.6 Supply plant. See § 1000.6....

  19. 7 CFR 1006.6 - Supply plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Supply plant. 1006.6 Section 1006.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1006.6 Supply plant. See § 1000.6....

  20. 7 CFR 1124.6 - Supply plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Supply plant. 1124.6 Section 1124.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Regulating Handling Definitions § 1124.6 Supply plant. See § 1000.6....

  1. 7 CFR 1007.6 - Supply plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Supply plant. 1007.6 Section 1007.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1007.6 Supply plant. See § 1000.6....

  2. 7 CFR 1005.6 - Supply plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Supply plant. 1005.6 Section 1005.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1005.6 Supply plant. See § 1000.6....

  3. 7 CFR 1032.6 - Supply plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Supply plant. 1032.6 Section 1032.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1032.6 Supply plant. See § 1000.6....

  4. 7 CFR 1126.6 - Supply plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Supply plant. 1126.6 Section 1126.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1126.6 Supply plant. See § 1000.6....

  5. 7 CFR 1126.6 - Supply plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Supply plant. 1126.6 Section 1126.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1126.6 Supply plant. See § 1000.6....

  6. 7 CFR 1001.6 - Supply plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Supply plant. 1001.6 Section 1001.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1001.6 Supply plant. See § 1000.6....

  7. 7 CFR 1001.6 - Supply plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Supply plant. 1001.6 Section 1001.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1001.6 Supply plant. See § 1000.6....

  8. 7 CFR 1030.6 - Supply plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Supply plant. 1030.6 Section 1030.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1030.6 Supply plant. See § 1000.6....

  9. 7 CFR 1030.6 - Supply plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Supply plant. 1030.6 Section 1030.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1030.6 Supply plant. See § 1000.6....

  10. 7 CFR 1032.6 - Supply plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Supply plant. 1032.6 Section 1032.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1032.6 Supply plant. See § 1000.6....

  11. 7 CFR 1033.6 - Supply plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Supply plant. 1033.6 Section 1033.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1033.6 Supply plant. See § 1000.6....

  12. 7 CFR 1124.6 - Supply plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Supply plant. 1124.6 Section 1124.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Regulating Handling Definitions § 1124.6 Supply plant. See § 1000.6....

  13. 7 CFR 1126.6 - Supply plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Supply plant. 1126.6 Section 1126.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1126.6 Supply plant. See § 1000.6....

  14. 7 CFR 1030.6 - Supply plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Supply plant. 1030.6 Section 1030.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1030.6 Supply plant. See § 1000.6....

  15. 7 CFR 1131.6 - Supply plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Supply plant. 1131.6 Section 1131.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1131.6 Supply plant. See § 1000.6....

  16. 7 CFR 1001.6 - Supply plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Supply plant. 1001.6 Section 1001.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1001.6 Supply plant. See § 1000.6....

  17. 7 CFR 1030.6 - Supply plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Supply plant. 1030.6 Section 1030.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1030.6 Supply plant. See § 1000.6....

  18. 7 CFR 1001.6 - Supply plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Supply plant. 1001.6 Section 1001.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1001.6 Supply plant. See § 1000.6....

  19. 7 CFR 1032.6 - Supply plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Supply plant. 1032.6 Section 1032.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1032.6 Supply plant. See § 1000.6....

  20. 7 CFR 1131.6 - Supply plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Supply plant. 1131.6 Section 1131.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1131.6 Supply plant. See § 1000.6....

  1. 7 CFR 1005.6 - Supply plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Supply plant. 1005.6 Section 1005.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1005.6 Supply plant. See § 1000.6....

  2. 7 CFR 1001.6 - Supply plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Supply plant. 1001.6 Section 1001.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1001.6 Supply plant. See § 1000.6....

  3. 7 CFR 1033.6 - Supply plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Supply plant. 1033.6 Section 1033.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1033.6 Supply plant. See § 1000.6....

  4. 7 CFR 1126.6 - Supply plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Supply plant. 1126.6 Section 1126.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1126.6 Supply plant. See § 1000.6....

  5. 7 CFR 1033.6 - Supply plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Supply plant. 1033.6 Section 1033.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1033.6 Supply plant. See § 1000.6....

  6. 7 CFR 1032.6 - Supply plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Supply plant. 1032.6 Section 1032.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1032.6 Supply plant. See § 1000.6....

  7. 7 CFR 1007.6 - Supply plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Supply plant. 1007.6 Section 1007.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1007.6 Supply plant. See § 1000.6....

  8. 7 CFR 1124.6 - Supply plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Supply plant. 1124.6 Section 1124.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Regulating Handling Definitions § 1124.6 Supply plant. See § 1000.6....

  9. 7 CFR 1131.6 - Supply plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Supply plant. 1131.6 Section 1131.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1131.6 Supply plant. See § 1000.6....

  10. 7 CFR 1005.6 - Supply plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Supply plant. 1005.6 Section 1005.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1005.6 Supply plant. See § 1000.6....

  11. 7 CFR 1030.6 - Supply plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Supply plant. 1030.6 Section 1030.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1030.6 Supply plant. See § 1000.6....

  12. 7 CFR 1007.6 - Supply plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Supply plant. 1007.6 Section 1007.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1007.6 Supply plant. See § 1000.6....

  13. 7 CFR 650.6 - Categorical exclusions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Categorical exclusions. 650.6 Section 650.6 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE SUPPORT ACTIVITIES COMPLIANCE WITH NEPA Procedures for NRCS-Assisted Programs § 650.6 Categorical exclusions. (a) Some...

  14. 7 CFR 650.6 - Categorical exclusions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Categorical exclusions. 650.6 Section 650.6 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE SUPPORT ACTIVITIES COMPLIANCE WITH NEPA Procedures for NRCS-Assisted Programs § 650.6 Categorical exclusions. (a) Some...

  15. 7 CFR 600.6 - Field offices.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Field offices. 600.6 Section 600.6 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE GENERAL ORGANIZATION § 600.6 Field offices. Each field office is under the direction...

  16. 7 CFR 600.6 - Field offices.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Field offices. 600.6 Section 600.6 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE GENERAL ORGANIZATION § 600.6 Field offices. Each field office is under the direction...

  17. 7 CFR 500.6 - Gambling.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Gambling. 500.6 Section 500.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE NATIONAL ARBORETUM Conduct on U.S. National Arboreturm Property § 500.6 Gambling. Participating in...

  18. 7 CFR 500.6 - Gambling.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Gambling. 500.6 Section 500.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE NATIONAL ARBORETUM Conduct on U.S. National Arboreturm Property § 500.6 Gambling. Participating in...

  19. 7 CFR 500.6 - Gambling.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Gambling. 500.6 Section 500.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE NATIONAL ARBORETUM Conduct on U.S. National Arboreturm Property § 500.6 Gambling. Participating in...

  20. Metal Complexes of Dithiolate Ligands: 5,6-Dihydro-1,4-dithiin-2,3-dithiolato (dddt(2-)), 5,7-Dihydro-1,4,6-trithiin-2,3-dithiolato (dtdt(2-)), and 2-Thioxo-1,3-dithiole-4,5-dithiolato (dmit(2-)). Synthesis, Electrochemical Studies, Crystal and Electronic Structures, and Conducting Properties.

    PubMed

    Faulmann, Christophe; Errami, Ahmed; Donnadieu, Bruno; Malfant, Isabelle; Legros, Jean-Pierre; Cassoux, Patrick; Rovira, Carme; Canadell, Enric

    1996-06-19

    New precursors to potentially conductive noninteger oxidation state (NIOS) compounds based on metal complexes [ML(2)](n)()(-) [M = Ni, Pd, Pt; L = 5,6-dihydro-1,4-dithiin-2,3-dithiolato (dddt(2)(-)), 5,7-dihydro-1,4,6-trithiin-2,3-dithiolato (dtdt(2)(-)), and 2-thioxo-1,3-dithiole-4,5-dithiolato (dmit(2)(-)); n = 2, 1, 0] have been investigated. Complexes of the series (NR(4))[ML(2)] (R = Me, Et, Bu; L = dddt(2)(-), dtdt(2)(-)) have been isolated and characterized, and the crystal structure of (NBu(4))[Pt(dtdt)(2)] (1) has been determined {1 = C(24)H(44)NPtS(10), a = 12.064(2) Å, b = 17.201(3) Å, c = 16.878(2) Å, beta = 102.22(2) degrees, V = 3423(1) Å(3), monoclinic, P2(1)/n, Z = 4}. Oxidation of these complexes affords the corresponding neutral species [ML(2)](0). Another series of general formula (cation)(n)()[M(dmit)(2)] [cation = PPN(+), BTP(+), and (SMe(y)()Et(3)(-)(y)())(+) with y = 0, 1, 2, and 3, n = 2, 1, M = Ni, Pd] has also been studied. All of these (cation)(n)()[M(dmit)(2)] complexes have been isolated and characterized [with the exception of (cation)[Pd(dmit)(2)] for cation = (SMe(y)()Et(3)(-)(y)())(+)]. The crystal structures of (PPN)[Ni(dmit)(2)].(CH(3))(2)CO (2) and (SMeEt(2))[Ni(dmit)(2)] (3) have been determined {2 = C(45)H(36)NNiS(10)P(2)O, a = 12.310(2) Å, b = 13.328(3) Å, c = 15.850(3) Å, alpha = 108.19(3) degrees, beta = 96.64(2) degrees, gamma = 99.67(2) degrees, V = 2373(1) Å(3), triclinic, P&onemacr;, Z = 2; 3 = C(11)H(13)NiS(11), a = 7.171(9) Å, b = 17.802(3) Å, c = 16.251(3) Å, beta = 94.39(4) degrees, V = 2068(2) Å(3), monoclinic, P2(1)/n, Z = 4} NIOS salts derived from the preceding precursors were obtained by electrochemical oxidation. Electrochemical studies of the [M(dddt)(2)] complexes show that they may be used for the preparation of NIOS radical cation salts and [M(dddt)(2)][M'(dmit)(2)](x)() compounds, but not for the preparation of (cation)[M(dddt)(2)](z)() NIOS radical anion salts. The electrochemical oxidation of

  1. 15 CFR 6.5 - Effective date of adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... INFLATION ADJUSTMENTS § 6.5 Effective date of adjustments. The adjustments made by § 6.4 of this part, of... December 7, 2012, and before the effective date of any future inflation adjustment thereto made...

  2. 15 CFR 6.5 - Effective date of adjustments.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... INFLATION ADJUSTMENTS § 6.5 Effective date of adjustments. The adjustments made by § 6.4 of this part, of... December 7, 2012, and before the effective date of any future inflation adjustment thereto made...

  3. 4 CFR 5.6 - Allowances.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 4 Accounts 1 2010-01-01 2010-01-01 false Allowances. 5.6 Section 5.6 Accounts GOVERNMENT ACCOUNTABILITY OFFICE PERSONNEL SYSTEM COMPENSATION § 5.6 Allowances. The provisions of chapter 59 of title 5, U.S. Code and the implementing regulations for the Executive Branch apply to Government...

  4. Intercalation Effect of 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimetane Having Strong Electron Affinity in Self-Assembled Monolayers Composed of Charge Transfer Complex Prepared by Coadsorption and Layer-by-Layer Adsorption Methods

    NASA Astrophysics Data System (ADS)

    Yuge, Ryota; Miyazaki, Akira; Enoki, Toshiaki; Tamada, Kaoru; Nakamura, Fumio; Hara, Masahiko

    2002-12-01

    Charge transfer (CT) complex self-assembled monolayers (SAMs) on a gold substrate are prepared using layer-by-layer adsorption and coadsorption methods with mercapto-methyl-tetrathiafulvalene (TTF-CH2SH) and strong acceptor 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane (TCNQF4), in comparison with TTF-CH2SH/TCNQ SAMs consisting of moderate acceptor TCNQ. The layer-by-layer method yields TTF-CH2SH/TCNQF4 SAMs with the coexistence of neutral TCNQF4 and anionic TCNQF4-, where the TCNQF4- anions are laid on the TTF layer with the TTF-CH2SH molecules standing perpendicular to the gold substrate. The neutral TCNQF4 molecules are stacked above the TCNQF4- anion layer. This is in contrast to the fact that TCNQ having intermediate strength of acceptor character does not yield any CT SAMs when using the layer-by-layer technique. In the coadsorption method, TTF-CH2SH/TCNQF4 SAMs are formed, where all the TCNQF4 molecules are completely reduced as TCNQF4- anions, similar to those in bulk TTF-TCNQF4 crystals. Taking into account that TTF-CH2SH/TCNQ SAMs have the same fractional value (0.6) of the degree of charge transfer to that of bulk TTF-TCNQ crystal, the coadsorption technique can reproduce the electronic structure of the bulk CT complex in the 2D SAMs. The coadsorbed SAMs have an intercalation structure, where acceptor molecules are intercalated into the interstitials of TTF-CH2SH/Au units with the molecular axes of both acceptor and donor molecules parallel to each other. Such a donor/acceptor molecular arrangement can provide a favorable situation in the charge transfer between the two ingredients, resulting in the similar electronic structure to that of bulk CT crystals.

  5. Food restriction alters N'-propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine dihydrochloride (pramipexole)-induced yawning, hypothermia, and locomotor activity in rats: evidence for sensitization of dopamine D2 receptor-mediated effects.

    PubMed

    Collins, Gregory T; Calinski, Diane M; Newman, Amy Hauck; Grundt, Peter; Woods, James H

    2008-05-01

    Food restriction enhances sensitivity to the reinforcing effects of a variety of drugs of abuse including opiates, nicotine, and psychostimulants. Food restriction has also been shown to alter a variety of behavioral and pharmacological responses to dopaminergic agonists, including an increased sensitivity to the locomotor stimulatory effects of direct- and indirect-dopamine agonists, elevated extracellular dopamine levels in responses to psychostimulants, as well as suppression of agonist-induced yawning. Behavioral and molecular studies suggest that augmented dopaminergic responses observed in food-restricted animals result from a sensitization of the dopamine D2 receptor; however, little is known about how food restriction affects dopamine D3 receptor function. The current studies were aimed at better defining the effects of food restriction on D2 and D3 receptor function by assessing the capacity of N'-propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine dihydrochloride (pramipexole) to induce yawning, penile erection (PE), hypothermia, and locomotor activity in free-fed and food-restricted rats. Food restriction resulted in a suppression of pramipexole-induced yawning, a sensitized hypothermic response, and an enhanced locomotor response to pramipexole, effects that are suggestive of an enhanced D2 receptor activity; no effect on pramipexole-induced PE was observed. Antagonist studies further supported a food restriction-induced enhancement of the D2 receptor activity because the D2 antagonist 3-[4-(4-chlorophenyl)-4-hydroxypiperidin-l-yl]methyl-1H-indole (L741,626) recovered pramipexole-induced yawning to free-fed levels, whereas yawning and PE were suppressed following pretreatment with the D3 antagonist N-{4-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-pyridine-2-yl-benzamide hydrochloride (PG01037). The results of the current studies suggest that food restriction sensitized rats to the D2-mediated effects of pramipexole while having no effect

  6. Non-additive hepatic gene expression elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153) co-treatment in C57BL/6 mice

    SciTech Connect

    Kopec, Anna K.; D'Souza, Michelle L.; Mets, Bryan D.; Burgoon, Lyle D.; Reese, Sarah E.; Archer, Kellie J.; Potter, Dave; Tashiro, Colleen; Sharratt, Bonnie; Harkema, Jack R.; Zacharewski, Timothy R.

    2011-10-15

    Interactions between environmental contaminants can lead to non-additive effects that may affect the toxicity and risk assessment of a mixture. Comprehensive time course and dose-response studies with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), non-dioxin-like 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153) and their mixture were performed in immature, ovariectomized C57BL/6 mice. Mice were gavaged once with 30 {mu}g/kg TCDD, 300 mg/kg PCB153, a mixture of 30 {mu}g/kg TCDD with 300 mg/kg PCB153 (MIX) or sesame oil vehicle for 4,12, 24,72 or 168 h. In the 24 h dose-response study, animals were gavaged with TCDD (0.3,1, 3, 6, 10, 15, 30, 45 {mu}g/kg), PCB153 (3,10, 30, 60, 100, 150, 300, 450 mg/kg), MIX (0.3 + 3, 1 + 10, 3 + 30, 6 + 60, 10 + 100, 15 + 150, 30 + 300, 45 {mu}g/kg TCDD + 450 mg/kg PCB153, respectively) or vehicle. All three treatments significantly increased relative liver weights (RLW), with MIX eliciting significantly greater increases compared to TCDD and PCB153 alone. Histologically, MIX induced hepatocellular hypertrophy, vacuolization, inflammation, hyperplasia and necrosis, a combination of TCDD and PCB153 responses. Complementary lipid analyses identified significant increases in hepatic triglycerides in MIX and TCDD samples, while PCB153 had no effect on lipids. Hepatic PCB153 levels were also significantly increased with TCDD co-treatment. Microarray analysis identified 167 TCDD, 185 PCB153 and 388 MIX unique differentially expressed genes. Statistical modeling of quantitative real-time PCR analysis of Pla2g12a, Serpinb6a, Nqo1, Srxn1, and Dysf verified non-additive expression following MIX treatment compared to TCDD and PCB153 alone. In summary, TCDD and PCB153 co-treatment elicited specific non-additive gene expression effects that are consistent with RLW increases, histopathology, and hepatic lipid accumulation. - Graphical abstract: Display Omitted Highlights: > MIX (TCDD:PCB153 at 1:10,000 ratio) exposure leads to non-additive gene expression

  7. Synthesis and photosensitivity characterizations of 9-(6-bromo-4-oxo-4H-chromen-3-yl)-3,4,6,7-tetrahydro-3,3,6,6-tetramethyl-2H-xanthene-1,8-(5H,9H)-dione(BOCTTX)

    NASA Astrophysics Data System (ADS)

    Ibrahim, Magdy A.; Farag, A. A. M.; Roushdy, N.; El-Gohary, Nasser M.

    2016-02-01

    Condensation reaction of 6-bromochromone-3-carboxaldehyde (1) with dimedone afforded 9-(6-bromo-4-oxo-4H-chromen-3-yl)-3,4,6,7-tetrahydro-3,3,6,6-tetramethyl-2H-xanthene-1,8-(5H,9H)-dione (3, BOCTTX). Structure of BOCTTX was deduced based on its correct elemental analysis and spectral data (IR, 1H NMR, 13C NMR and mass spectra). Thin films of BOCTTX were prepared in this study by using spin coating technique. X-ray diffraction, scanning electron microscope analysis were studied for study the crystal and morphology characterization of BOCTTX. The results indicate that BOCTTX has a polycrystalline nature with monoclinic structure. From differential scanning calorimetry, BOCTTX is found to be thermally stable up to 583 K and the chemical structure plays an important role in the thermal decomposition process. The optical absorption of the film was studied in the UV-Vis spectral range and the value of two allowed energy gaps of 2.2 and 3.3 eV. Current-voltage characteristics of BOCTTX based devices were studied in dark and under various illumination intensities in the range 20-100 mW/cm2. Electrical and photoelectrical parameters were studied as a function of light intensity. The obtained results exhibits photoconductivity cauterization and suggest that the diode can be used as a photodiode in optoelectronic sensor application.

  8. 5 CFR 6.5 - Assignment of excepted employees.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Assignment of excepted employees. 6.5 Section 6.5 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES EXCEPTIONS FROM THE COMPETITIVE SERVICE (RULE VI) § 6.5 Assignment of excepted employees. No person who is...

  9. 5 CFR 6.5 - Assignment of excepted employees.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Assignment of excepted employees. 6.5 Section 6.5 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES EXCEPTIONS FROM THE COMPETITIVE SERVICE (RULE VI) § 6.5 Assignment of excepted employees. No person who is...

  10. 5 CFR 6.5 - Assignment of excepted employees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Assignment of excepted employees. 6.5 Section 6.5 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES EXCEPTIONS FROM THE COMPETITIVE SERVICE (RULE VI) § 6.5 Assignment of excepted employees. No person who is...

  11. 5 CFR 6.5 - Assignment of excepted employees.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Assignment of excepted employees. 6.5 Section 6.5 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES EXCEPTIONS FROM THE COMPETITIVE SERVICE (RULE VI) § 6.5 Assignment of excepted employees. No person who is...

  12. 5 CFR 6.5 - Assignment of excepted employees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Assignment of excepted employees. 6.5 Section 6.5 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES EXCEPTIONS FROM THE COMPETITIVE SERVICE (RULE VI) § 6.5 Assignment of excepted employees. No person who is...

  13. z ≳ 7 Galaxies with Red Spitzer/IRAC [3.6]-[4.5] Colors in the Full CANDELS Data Set: The Brightest-Known Galaxies at z ~ 7-9 and a Probable Spectroscopic Confirmation at z = 7.48

    NASA Astrophysics Data System (ADS)

    Roberts-Borsani, G. W.; Bouwens, R. J.; Oesch, P. A.; Labbe, I.; Smit, R.; Illingworth, G. D.; van Dokkum, P.; Holden, B.; Gonzalez, V.; Stefanon, M.; Holwerda, B.; Wilkins, S.

    2016-06-01

    We identify four unusually bright (H {}160,{AB} < 25.5) galaxies from Hubble Space Telescope (HST) and Spitzer CANDELS data with probable redshifts z ∼ 7–9. These identifications include the brightest-known galaxies to date at z ≳ 7.5. As Y-band observations are not available over the full CANDELS program to perform a standard Lyman-break selection of z > 7 galaxies, we employ an alternate strategy using deep Spitzer/IRAC data. We identify z ∼ 7.1–9.1 galaxies by selecting z ≳ 6 galaxies from the HST CANDELS data that show quite red IRAC [3.6]‑[4.5] colors, indicating strong [O iii]+Hβ lines in the 4.5 μm band. This selection strategy was validated using a modest sample for which we have deep Y-band coverage, and subsequently used to select the brightest z ≥ 7 sources. Applying the IRAC criteria to all HST-selected optical dropout galaxies over the full ∼900 arcmin2 of the CANDELS survey revealed four unusually bright z ∼ 7.1, 7.6, 7.9, and 8.6 candidates. The median [3.6]‑[4.5] color of our selected z ∼ 7.1–9.1 sample is consistent with rest-frame [O iii]+Hβ EWs of ∼1500 Å in the [4.5] band. Keck/MOSFIRE spectroscopy has been independently reported for two of our selected sources, showing Lyα at redshifts of 7.7302 ± 0.0006 and {8.683}-0.004+0.001, respectively. We present similar Keck/MOSFIRE spectroscopy for a third selected galaxy with a probable 4.7σ Lyα line at z spec = 7.4770 ± 0.0008. All three have H160-band magnitudes of ∼25 mag and are ∼0.5 mag more luminous (M 1600 ∼ ‑22.0) than any previously discovered z ∼ 8 galaxy, with important implications for the UV luminosity function (LF). Our three brightest and highest redshift z > 7 galaxies all lie within the CANDELS-EGS field, providing a dramatic illustration of the potential impact of field-to-field variance.

  14. 6 CFR 25.7 - Litigation management.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 6 Domestic Security 1 2013-01-01 2013-01-01 false Litigation management. 25.7 Section 25.7 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY REGULATIONS TO SUPPORT ANTI-TERRORISM BY FOSTERING EFFECTIVE TECHNOLOGIES § 25.7 Litigation management. (a) Liability for all...

  15. 6 CFR 25.7 - Litigation management.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 6 Domestic Security 1 2014-01-01 2014-01-01 false Litigation management. 25.7 Section 25.7 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY REGULATIONS TO SUPPORT ANTI-TERRORISM BY FOSTERING EFFECTIVE TECHNOLOGIES § 25.7 Litigation management. (a) Liability for all...

  16. 6 CFR 25.7 - Litigation management.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 6 Domestic Security 1 2011-01-01 2011-01-01 false Litigation management. 25.7 Section 25.7 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY REGULATIONS TO SUPPORT ANTI-TERRORISM BY FOSTERING EFFECTIVE TECHNOLOGIES § 25.7 Litigation management. (a) Liability for all...

  17. 6 CFR 25.7 - Litigation management.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Litigation management. 25.7 Section 25.7 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY REGULATIONS TO SUPPORT ANTI-TERRORISM BY FOSTERING EFFECTIVE TECHNOLOGIES § 25.7 Litigation management. (a) Liability for all...

  18. 6 CFR 25.7 - Litigation management.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Litigation management. 25.7 Section 25.7 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY REGULATIONS TO SUPPORT ANTI-TERRORISM BY FOSTERING EFFECTIVE TECHNOLOGIES § 25.7 Litigation management. (a) Liability for all...

  19. 6 CFR 7.2 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 6 Domestic Security 1 2014-01-01 2014-01-01 false Scope. 7.2 Section 7.2 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION § 7.2 Scope... Branch who are granted access to classified information by the DHS, in accordance with the standards...

  20. 6 CFR 7.2 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Scope. 7.2 Section 7.2 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION § 7.2 Scope... Branch who are granted access to classified information by the DHS, in accordance with the standards...

  1. 6 CFR 7.3 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 6 Domestic Security 1 2011-01-01 2011-01-01 false Definitions. 7.3 Section 7.3 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION § 7.3... in 32 CFR parts 2001 and 2004, are applicable to this part....

  2. 6 CFR 7.2 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 6 Domestic Security 1 2011-01-01 2011-01-01 false Scope. 7.2 Section 7.2 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION § 7.2 Scope... Branch who are granted access to classified information by the DHS, in accordance with the standards...

  3. 6 CFR 7.3 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Definitions. 7.3 Section 7.3 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION § 7.3... in 32 CFR parts 2001 and 2004, are applicable to this part....

  4. 6 CFR 7.3 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Definitions. 7.3 Section 7.3 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION § 7.3... in 32 CFR parts 2001 and 2004, are applicable to this part....

  5. 6 CFR 7.2 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 6 Domestic Security 1 2013-01-01 2013-01-01 false Scope. 7.2 Section 7.2 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION § 7.2 Scope... Branch who are granted access to classified information by the DHS, in accordance with the standards...

  6. 6 CFR 7.3 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 6 Domestic Security 1 2013-01-01 2013-01-01 false Definitions. 7.3 Section 7.3 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION § 7.3... in 32 CFR parts 2001 and 2004, are applicable to this part....

  7. 6 CFR 7.3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 6 Domestic Security 1 2014-01-01 2014-01-01 false Definitions. 7.3 Section 7.3 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION § 7.3... in 32 CFR parts 2001 and 2004, are applicable to this part....

  8. 6 CFR 7.2 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Scope. 7.2 Section 7.2 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION § 7.2 Scope... Branch who are granted access to classified information by the DHS, in accordance with the standards...

  9. Discovery of 8-Cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a Potent Inhibitor of Cyclin-Dependent Kinase 4 (CDK4) and AMPK-Related Kinase 5 (ARK5)

    PubMed Central

    2015-01-01

    The success of imatinib, a BCR-ABL inhibitor for the treatment of chronic myelogenous leukemia, has created a great impetus for the development of additional kinase inhibitors as therapeutic agents. However, the complexity of cancer has led to recent interest in polypharmacological approaches for developing multikinase inhibitors with low toxicity profiles. With this goal in mind, we analyzed more than 150 novel cyano pyridopyrimidine compounds and identified structure–activity relationship trends that can be exploited in the design of potent kinase inhibitors. One compound, 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x), was found to be the most active, inducing apoptosis of tumor cells at a concentration of approximately 30–100 nM. In vitro kinase profiling revealed that 7x is a multikinase inhibitor with potent inhibitory activity against the CDK4/CYCLIN D1 and ARK5 kinases. Here, we report the synthesis, structure–activity relationship, kinase inhibitory profile, in vitro cytotoxicity, and in vivo tumor regression studies by this lead compound. PMID:24417566

  10. Multi-Step Protocol for Automatic Evaluation of Docking Results Based on Machine Learning Methods--A Case Study of Serotonin Receptors 5-HT(6) and 5-HT(7).

    PubMed

    Smusz, Sabina; Mordalski, Stefan; Witek, Jagna; Rataj, Krzysztof; Kafel, Rafał; Bojarski, Andrzej J

    2015-04-27

    Molecular docking, despite its undeniable usefulness in computer-aided drug design protocols and the increasing sophistication of tools used in the prediction of ligand-protein interaction energies, is still connected with a problem of effective results analysis. In this study, a novel protocol for the automatic evaluation of numerous docking results is presented, being a combination of Structural Interaction Fingerprints and Spectrophores descriptors, machine-learning techniques, and multi-step results analysis. Such an approach takes into consideration the performance of a particular learning algorithm (five machine learning methods were applied), the performance of the docking algorithm itself, the variety of conformations returned from the docking experiment, and the receptor structure (homology models were constructed on five different templates). Evaluation using compounds active toward 5-HT6 and 5-HT7 receptors, as well as additional analysis carried out for beta-2 adrenergic receptor ligands, proved that the methodology is a viable tool for supporting virtual screening protocols, enabling proper discrimination between active and inactive compounds. PMID:25806997

  11. Repeated dose toxicity and relative potency of 1,2,3,4,6,7-hexachloronaphthalene (PCN 66) 1,2,3,5,6,7-hexachloronaphthalene (PCN 67) compared to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) for induction of CYP1A1, CYP1A2 and thymic atrophy in female Harlan Sprague-Dawley rats

    PubMed Central

    Hooth, Michelle J.; Nyska, Abraham; Fomby, Laurene M.; Vasconcelos, Daphne Y.; Vallant, Molly; DeVito, Michael J.; Walker, Nigel J.

    2012-01-01

    In this study we assessed the relative toxicity and potency of the chlorinated naphthalenes 1,2,3,4,6,7-hexachloronaphthalene (PCN 66) and 1,2,3,5,6,7-hexachloronaphthalene (PCN 67) relative to that of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Chemicals were administered in corn oil:acetone (99:1) by gavage to female Harlan Sprague-Dawley rats at dosages of 0 (vehicle), 500, 1500, 5000, 50000 and 500000 ng/kg (PCN 66 and PCN 67) and 1, 3, 10, 100, and 300 ng/kg (TCDD) for 2 weeks. Histopathologic changes were observed in the thymus, liver and lung of TCDD treated animals and in the liver and thymus of PCN treated animals. Significant increases in CYP1A1 and CYP1A2 associated enzyme activity were observed in all animals exposed to TCDD, PCN 66 and PCN 67. Dose response modeling of CYP1A1, CYP1A2 and thymic atrophy gave ranges of estimated relative potencies, as compared to TCDD, of 0.0015-0.0072, for PCN 66 and 0.00029-0.00067 for PCN 67. Given that PCN 66 and PCN 67 exposure resulted in biochemical and histopathologic changes similar to that seen with TCDD, this suggests that they should be included in the WHO Toxic Equivalency Factor (TEF) scheme, although the estimated relative potencies indicate that these hexachlorinated naphthalenes should not contribute greatly to the overall human body burden of dioxin-like activity. PMID:22813907

  12. 18 CFR 6.5 - Annual charges.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Annual charges. 6.5 Section 6.5 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT SURRENDER OR TERMINATION OF LICENSE § 6.5 Annual...

  13. 18 CFR 6.5 - Annual charges.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Annual charges. 6.5 Section 6.5 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT SURRENDER OR TERMINATION OF LICENSE § 6.5 Annual...

  14. 18 CFR 6.5 - Annual charges.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Annual charges. 6.5 Section 6.5 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT SURRENDER OR TERMINATION OF LICENSE § 6.5 Annual...

  15. 18 CFR 6.5 - Annual charges.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Annual charges. 6.5 Section 6.5 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT SURRENDER OR TERMINATION OF LICENSE § 6.5 Annual...

  16. 18 CFR 6.5 - Annual charges.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Annual charges. 6.5 Section 6.5 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT SURRENDER OR TERMINATION OF LICENSE § 6.5 Annual...

  17. 1 CFR 5.6 - Daily publication.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Daily publication. 5.6 Section 5.6 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.6 Daily publication. There shall be an edition of the Federal Register published for each official Federal working day....

  18. 1 CFR 5.6 - Daily publication.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Daily publication. 5.6 Section 5.6 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.6 Daily publication. There shall be an edition of the Federal Register published for each official Federal working day....

  19. 1 CFR 5.6 - Daily publication.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Daily publication. 5.6 Section 5.6 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.6 Daily publication. There shall be an edition of the Federal Register published for each official Federal working day....

  20. 1 CFR 5.6 - Daily publication.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Daily publication. 5.6 Section 5.6 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.6 Daily publication. There shall be an edition of the Federal Register published for each official Federal working day....

  1. 1 CFR 5.6 - Daily publication.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Daily publication. 5.6 Section 5.6 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.6 Daily publication. There shall be an edition of the Federal Register published for each official Federal working day....

  2. 7 CFR 1540.6 - Information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Information. 1540.6 Section 1540.6 Agriculture Regulations of the Department of Agriculture (Continued) FOREIGN AGRICULTURAL SERVICE, DEPARTMENT OF... § 1540.6 Information. Persons desiring information from the Department of Agriculture regarding...

  3. 7 CFR 6.9 - Information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Information. 6.9 Section 6.9 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES General Provisions § 6.9 Information. Persons desiring information from the Department of Agriculture regarding section 22 or section 8(a), or any action...

  4. 7 CFR 56.6 - Supervision.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Supervision. 56.6 Section 56.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections... Grading of Shell Eggs General § 56.6 Supervision. All grading service shall be subject to supervision...

  5. 7 CFR 6.36 - Miscellaneous.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Miscellaneous. 6.36 Section 6.36 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES Dairy Tariff-Rate Import Quota Licensing § 6.36... proper postage affixed and properly addressed to the Dairy Import Licensing Group, STOP 1021,...

  6. 7 CFR 6.36 - Miscellaneous.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Miscellaneous. 6.36 Section 6.36 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES Dairy Tariff-Rate Import Quota Licensing § 6.36... proper postage affixed and properly addressed to the Dairy Import Licensing Group, STOP 1021,...

  7. 7 CFR 6.33 - License fee.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false License fee. 6.33 Section 6.33 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES Dairy Tariff-Rate Import Quota Licensing § 6.33 License fee. (a) A fee will be assessed each quota year for each license to defray the Department's...

  8. 7 CFR 6.33 - License fee.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false License fee. 6.33 Section 6.33 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES Dairy Tariff-Rate Import Quota Licensing § 6.33 License fee. (a) A fee will be assessed each quota year for each license to defray the Department's...

  9. 7 CFR 3601.6 - Appeals.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Appeals. 3601.6 Section 3601.6 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL AGRICULTURAL STATISTICS SERVICE, DEPARTMENT OF AGRICULTURE PUBLIC INFORMATION § 3601.6 Appeals. Any person whose request is denied shall have...

  10. 7 CFR 247.6 - State Plan.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false State Plan. 247.6 Section 247.6 Agriculture... CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.6 State Plan. (a) What is the State Plan? The State Plan is a document that describes how the State agency will operate CSFP and...

  11. 7 CFR 247.6 - State Plan.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false State Plan. 247.6 Section 247.6 Agriculture... CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.6 State Plan. (a) What is the State Plan? The State Plan is a document that describes how the State agency will operate CSFP and...

  12. 7 CFR 247.6 - State Plan.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false State Plan. 247.6 Section 247.6 Agriculture... CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.6 State Plan. (a) What is the State Plan? The State Plan is a document that describes how the State agency will operate CSFP and...

  13. 7 CFR 3411.6 - Grant awards.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Grant awards. 3411.6 Section 3411.6 Agriculture... RESEARCH INITIATIVE COMPETITIVE GRANTS PROGRAM General § 3411.6 Grant awards. (a) General. Within the limit of funds available for such purpose, the awarding official shall make grants to those...

  14. 7 CFR 948.6 - Seed potatoes.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Seed potatoes. 948.6 Section 948.6 Agriculture... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE IRISH POTATOES GROWN IN COLORADO Order Regulating Handling Definitions § 948.6 Seed potatoes. Seed potatoes or seed means any...

  15. 7 CFR 948.6 - Seed potatoes.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Seed potatoes. 948.6 Section 948.6 Agriculture... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE IRISH POTATOES GROWN IN COLORADO Order Regulating Handling Definitions § 948.6 Seed potatoes. Seed potatoes or seed means any...

  16. 7 CFR 948.6 - Seed potatoes.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Seed potatoes. 948.6 Section 948.6 Agriculture... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE IRISH POTATOES GROWN IN COLORADO Order Regulating Handling Definitions § 948.6 Seed potatoes. Seed potatoes or seed means any...

  17. 7 CFR 948.6 - Seed potatoes.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Seed potatoes. 948.6 Section 948.6 Agriculture... AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE IRISH POTATOES GROWN IN COLORADO Order Regulating Handling Definitions § 948.6 Seed potatoes. Seed potatoes or seed means any...

  18. 7 CFR 948.6 - Seed potatoes.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Seed potatoes. 948.6 Section 948.6 Agriculture... AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE IRISH POTATOES GROWN IN COLORADO Order Regulating Handling Definitions § 948.6 Seed potatoes. Seed potatoes or seed means any...

  19. 7 CFR 1540.6 - Information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Information. 1540.6 Section 1540.6 Agriculture Regulations of the Department of Agriculture (Continued) FOREIGN AGRICULTURAL SERVICE, DEPARTMENT OF... § 1540.6 Information. Persons desiring information from the Department of Agriculture regarding...

  20. 7 CFR 6.9 - Information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Information. 6.9 Section 6.9 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES General Provisions § 6.9 Information. Persons desiring information from the Department of Agriculture regarding section 22 or section 8(a), or any action...

  1. 7 CFR 1540.6 - Information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Information. 1540.6 Section 1540.6 Agriculture Regulations of the Department of Agriculture (Continued) FOREIGN AGRICULTURAL SERVICE, DEPARTMENT OF... § 1540.6 Information. Persons desiring information from the Department of Agriculture regarding...

  2. 7 CFR 1540.6 - Information.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Information. 1540.6 Section 1540.6 Agriculture Regulations of the Department of Agriculture (Continued) FOREIGN AGRICULTURAL SERVICE, DEPARTMENT OF... § 1540.6 Information. Persons desiring information from the Department of Agriculture regarding...

  3. 7 CFR 6.9 - Information.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false Information. 6.9 Section 6.9 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES General Provisions § 6.9 Information. Persons desiring information from the Department of Agriculture regarding section 22 or section 8(a), or any action...

  4. 7 CFR 6.9 - Information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Information. 6.9 Section 6.9 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES General Provisions § 6.9 Information. Persons desiring information from the Department of Agriculture regarding section 22 or section 8(a), or any action...

  5. 7 CFR 6.9 - Information.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 1 2014-01-01 2014-01-01 false Information. 6.9 Section 6.9 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES General Provisions § 6.9 Information. Persons desiring information from the Department of Agriculture regarding section 22 or section 8(a), or any action...

  6. 7 CFR 1540.6 - Information.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Information. 1540.6 Section 1540.6 Agriculture Regulations of the Department of Agriculture (Continued) FOREIGN AGRICULTURAL SERVICE, DEPARTMENT OF... § 1540.6 Information. Persons desiring information from the Department of Agriculture regarding...

  7. 7 CFR 3415.6 - Grant awards.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Grant awards. 3415.6 Section 3415.6 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE BIOTECHNOLOGY RISK ASSESSMENT RESEARCH GRANTS PROGRAM General § 3415.6 Grant awards. (a) General. Within...

  8. 7 CFR 3415.6 - Grant awards.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Grant awards. 3415.6 Section 3415.6 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE BIOTECHNOLOGY RISK ASSESSMENT RESEARCH GRANTS PROGRAM General § 3415.6 Grant awards. (a) General. Within...

  9. 7 CFR 3415.6 - Grant awards.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Grant awards. 3415.6 Section 3415.6 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE BIOTECHNOLOGY RISK ASSESSMENT RESEARCH GRANTS PROGRAM General § 3415.6 Grant awards. (a) General. Within...

  10. 7 CFR 275.6 - Management units.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Management units. 275.6 Section 275.6 Agriculture... FOOD STAMP AND FOOD DISTRIBUTION PROGRAM PERFORMANCE REPORTING SYSTEM Management Evaluation (ME) Reviews § 275.6 Management units. (a) Establishment of management units. For the purpose of ME...

  11. 7 CFR 1221.6 - Crop year.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Crop year. 1221.6 Section 1221.6 Agriculture... INFORMATION ORDER Sorghum Promotion, Research, and Information Order Definitions § 1221.6 Crop year. Crop year... calendar year in which sorghum is normally harvested....

  12. 7 CFR 987.6 - Crop year.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Crop year. 987.6 Section 987.6 Agriculture Regulations... RIVERSIDE COUNTY, CALIFORNIA Order Regulating Handling Definitions § 987.6 Crop year. Crop year means the 12-month period beginning October 1 of each year and ending September 30 of the following year....

  13. 7 CFR 1221.6 - Crop year.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Crop year. 1221.6 Section 1221.6 Agriculture... INFORMATION ORDER Sorghum Promotion, Research, and Information Order Definitions § 1221.6 Crop year. Crop year... calendar year in which sorghum is normally harvested....

  14. 7 CFR 63.6 - Fiscal year.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Fiscal year. 63.6 Section 63.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections... CENTER General Provisions Definitions § 63.6 Fiscal year. Fiscal year means a calendar year or any...

  15. 7 CFR 275.6 - Management units.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Management units. 275.6 Section 275.6 Agriculture... FOOD STAMP AND FOOD DISTRIBUTION PROGRAM PERFORMANCE REPORTING SYSTEM Management Evaluation (ME) Reviews § 275.6 Management units. (a) Establishment of management units. For the purpose of ME...

  16. 7 CFR 275.6 - Management units.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Management units. 275.6 Section 275.6 Agriculture... FOOD STAMP AND FOOD DISTRIBUTION PROGRAM PERFORMANCE REPORTING SYSTEM Management Evaluation (ME) Reviews § 275.6 Management units. (a) Establishment of management units. For the purpose of ME...

  17. 7 CFR 1425.6 - Approved CMA's.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Approved CMA's. 1425.6 Section 1425.6 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS COOPERATIVE MARKETING ASSOCIATIONS § 1425.6 Approved...

  18. 7 CFR 1170.6 - Store.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Store. 1170.6 Section 1170.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE DAIRY PRODUCT MANDATORY REPORTING § 1170.6 Store. (a)...

  19. 7 CFR 3407.6 - Categorical exclusions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Categorical exclusions. 3407.6 Section 3407.6 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE IMPLEMENTATION OF NATIONAL ENVIRONMENTAL POLICY ACT § 3407.6 Categorical exclusions. (a) All CSREES actions will be analyzed by the...

  20. 7 CFR 6.41 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 1 2014-01-01 2014-01-01 false Definitions. 6.41 Section 6.41 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES Price-Undercutting of Domestic Cheese by Quota Cheeses § 6.41 Definitions. (a) Complainant means the person who has filed with the Investigating Authority, in accordance with the procedures set...

  1. 7 CFR 3404.6 - Appeals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Appeals. 3404.6 Section 3404.6 Agriculture Regulations of the Department of Agriculture (Continued) COOPERATIVE STATE RESEARCH, EDUCATION, AND EXTENSION SERVICE, DEPARTMENT OF AGRICULTURE PUBLIC INFORMATION § 3404.6 Appeals. Any person whose request is...

  2. 7 CFR 2903.6 - Project types.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Project types. 2903.6 Section 2903.6 Agriculture... AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM Program Description § 2903.6 Project types. OEPNU intends to... predetermined project period with a statement of intention to provide additional support at a future...

  3. 7 CFR 2903.6 - Project types.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Project types. 2903.6 Section 2903.6 Agriculture... AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM Program Description § 2903.6 Project types. OEPNU intends to... predetermined project period with a statement of intention to provide additional support at a future...

  4. 7 CFR 2903.6 - Project types.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Project types. 2903.6 Section 2903.6 Agriculture... AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM Program Description § 2903.6 Project types. OEPNU intends to... predetermined project period with a statement of intention to provide additional support at a future...

  5. 7 CFR 6.40 - General.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false General. 6.40 Section 6.40 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES Price-Undercutting of Domestic Cheese by Quota Cheeses § 6... of Agriculture as to whether the price at which any article of quota cheese is being offered for...

  6. 7 CFR 6.40 - General.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false General. 6.40 Section 6.40 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES Price-Undercutting of Domestic Cheese by Quota Cheeses § 6... of Agriculture as to whether the price at which any article of quota cheese is being offered for...

  7. 7 CFR 6.40 - General.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 1 2014-01-01 2014-01-01 false General. 6.40 Section 6.40 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES Price-Undercutting of Domestic Cheese by Quota Cheeses § 6... of Agriculture as to whether the price at which any article of quota cheese is being offered for...

  8. 7 CFR 6.40 - General.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false General. 6.40 Section 6.40 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES Price-Undercutting of Domestic Cheese by Quota Cheeses § 6... of Agriculture as to whether the price at which any article of quota cheese is being offered for...

  9. 7 CFR 6.40 - General.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false General. 6.40 Section 6.40 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES Price-Undercutting of Domestic Cheese by Quota Cheeses § 6... of Agriculture as to whether the price at which any article of quota cheese is being offered for...

  10. 7 CFR 1000.6 - Supply plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Supply plant. 1000.6 Section 1000.6 Agriculture... Definitions § 1000.6 Supply plant. Supply plant means a plant approved by a duly constituted regulatory agency... diverts fluid milk products to other plants or manufactures dairy products on its premises....

  11. 7 CFR 1000.6 - Supply plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Supply plant. 1000.6 Section 1000.6 Agriculture... Definitions § 1000.6 Supply plant. Supply plant means a plant approved by a duly constituted regulatory agency... diverts fluid milk products to other plants or manufactures dairy products on its premises....

  12. 7 CFR 1000.6 - Supply plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Supply plant. 1000.6 Section 1000.6 Agriculture... Definitions § 1000.6 Supply plant. Supply plant means a plant approved by a duly constituted regulatory agency... diverts fluid milk products to other plants or manufactures dairy products on its premises....

  13. 7 CFR 1000.6 - Supply plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Supply plant. 1000.6 Section 1000.6 Agriculture... Definitions § 1000.6 Supply plant. Supply plant means a plant approved by a duly constituted regulatory agency... diverts fluid milk products to other plants or manufactures dairy products on its premises....

  14. 7 CFR 1000.6 - Supply plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Supply plant. 1000.6 Section 1000.6 Agriculture... Definitions § 1000.6 Supply plant. Supply plant means a plant approved by a duly constituted regulatory agency... diverts fluid milk products to other plants or manufactures dairy products on its premises....

  15. 7 CFR 981.6 - Shelled almonds.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Shelled almonds. 981.6 Section 981.6 Agriculture... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE ALMONDS GROWN IN CALIFORNIA Order Regulating Handling Definitions § 981.6 Shelled almonds. Shelled almonds mean raw or roasted almonds...

  16. 7 CFR 981.6 - Shelled almonds.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Shelled almonds. 981.6 Section 981.6 Agriculture... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE ALMONDS GROWN IN CALIFORNIA Order Regulating Handling Definitions § 981.6 Shelled almonds. Shelled almonds mean raw or roasted almonds...

  17. 7 CFR 981.6 - Shelled almonds.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Shelled almonds. 981.6 Section 981.6 Agriculture... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE ALMONDS GROWN IN CALIFORNIA Order Regulating Handling Definitions § 981.6 Shelled almonds. Shelled almonds mean raw or roasted almonds...

  18. 7 CFR 981.6 - Shelled almonds.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Shelled almonds. 981.6 Section 981.6 Agriculture... AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE ALMONDS GROWN IN CALIFORNIA Order Regulating Handling Definitions § 981.6 Shelled almonds. Shelled almonds mean raw or roasted almonds...

  19. 7 CFR 981.6 - Shelled almonds.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Shelled almonds. 981.6 Section 981.6 Agriculture... AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE ALMONDS GROWN IN CALIFORNIA Order Regulating Handling Definitions § 981.6 Shelled almonds. Shelled almonds mean raw or roasted almonds...

  20. 7 CFR 276.6 - Good cause.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Good cause. 276.6 Section 276.6 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE FOOD STAMP AND FOOD DISTRIBUTION PROGRAM STATE AGENCY LIABILITIES AND FEDERAL SANCTIONS § 276.6...