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Sample records for 737-100 200 200c

  1. 75 FR 10658 - Airworthiness Directives; The Boeing Company Model 737-100, -200, -200C, -300, -400, and -500...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-09

    ... Model 737-100, -200, -200C, -300, -400, and -500 Series Airplanes AGENCY: Federal Aviation... existing airworthiness directive (AD) that applies to all Model 737-100, -200, -200C, -300, -400, and - 500...-100, -200, -200C, -300, -400, and -500 series airplanes. That NPRM was published in the...

  2. 75 FR 53843 - Airworthiness Directives; The Boeing Company Model 737-100 and -200 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-02

    ... to be approved, the repair must meet the certification basis of the airplane. Material Incorporated... Model 737-100 and - 200 Series Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION... -200 series airplanes. This AD requires repetitive inspections for cracking and damaged fasteners...

  3. DYNAMIC LOADING OF TEFLON AT 200?C

    SciTech Connect

    Urtiew, P A; Forbes, J W; Tarver, C M; Vandersall, K S; Garcia, F

    2007-06-13

    Dynamic loading experiments were performed on inert Teflon (Polytetrafluoroethylene) samples, initially heated to the temperature of 200 C, to test its behavior under these conditions for its use in other heated experiments. Tests were performed in the 100 mm diameter bore propellant driven gas gun with piezo-resistive manganin pressure gauges imbedded into the samples to measure loading pressures. Experimental data provided new information on the shock velocity - particle velocity relationship for the heated material and showed no adverse effect of temperature on the insulating properties of the material.

  4. 75 FR 9137 - Airworthiness Directives; The Boeing Company Model 737-100, -200, -200C, -300, -400, and -500...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-01

    ... measurements taken at three locations. This proposed AD also would require new repetitive inspections, measurements, and overhaul of the carriage spindles, and applicable corrective actions. In addition, this..., and cracks) of the carriage spindle, repetitive measurements to determine the diameter of...

  5. 76 FR 47522 - Airworthiness Directives; The Boeing Company Model 737-100, -200, -200C, -300, -400, and -500...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-05

    ... at BS 727 and in the radius of the auxiliary chord on airplanes that were not affected by the... inspections for cracks in the BS 727 frame outboard chords and the radius of the auxiliary chord, for certain... the frame outboard chord at BS 727 and in the radius of the auxiliary chord. The cracking in...

  6. 76 FR 72858 - Airworthiness Directives; The Boeing Company Model 737-100, -200, -200C, -300, -400, and -500...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... cracking of the reinforcement angle and shear web, and doing a detailed inspection for cracking of the STA 348.2 frame outer chord, inner chord, and reinforcement angle, and corrective actions if necessary..., reinforcement angle, and shear web; and of the door stop intercostals at S-14L through S16L. ]...

  7. 75 FR 43803 - Airworthiness Directives; The Boeing Company Model 737-100, -200, -200C, -300, -400, and -500...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-27

    ... corrosion of each carriage spindle of the left and right outboard mid-flaps, and corrective action if... AD results from reports of fractures that resulted from stress corrosion and pitting along the length of the spindle and spindle diameter, and additional reports of corrosion on the outboard...

  8. 76 FR 33988 - Airworthiness Directives; The Boeing Company Model 737-100, -200, -200C, -300, -400, and -500...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-10

    ... resistance measurements, and modifying relay module assemblies. This AD also requires revising the... applicable, with new relays having a GFI feature, performing certain bonding resistance measurements, and...: Wiring Changes, Relay Replacements, and Certain Bonding Resistance Measurements for Certain Airplanes...

  9. 76 FR 63229 - Airworthiness Directives; The Boeing Company Model 737-100, -200, -200C, -300, -400, and -500...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-12

    ... require installing an automatic shutoff system for the center and auxiliary tank fuel boost pumps, as... tank fuel boost pumps, as applicable. This proposed AD would also require revisions to the Limitations... require revising the maintenance program by incorporating new airworthiness limitations for fuel...

  10. 76 FR 3856 - Airworthiness Directives; The Boeing Company Model 737-100, -200, -200C, -300, -400, and -500...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-21

    ..., replacing the fuel pump power control relays for the main, center and auxiliary tanks, as applicable, with... relay module assemblies. The proposed AD also would require revising the maintenance program to... to the fuel pumps caused by electrical arcing that could introduce an ignition source in the...

  11. 75 FR 48620 - Airworthiness Directives; The Boeing Company Model 737-100, -200, -200C, -300, -400, and -500...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-11

    ... flightcrew due to hypoxia (lack of oxygen in body), and consequent loss of control of the airplane. DATES: We... warning horn could result in incapacitation of the flightcrew due to hypoxia (lack of oxygen in body), and... requires revising the airplane flight manual (AFM) to advise the flightcrew to don oxygen masks as a...

  12. 76 FR 6529 - Airworthiness Directives; The Boeing Company Model 737-100, -200, -200C, -300, -400, and -500...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-07

    ... the flightcrew due to hypoxia (lack of oxygen in body), and consequent loss of control of the airplane... the flightcrew due to hypoxia (lack of oxygen in body) and consequent loss of control of the airplane... above 10,000 ft MSL. RECALL Oxygen Masks and Regulators ON, 100% Crew Communications ESTABLISH...

  13. Operational characteristics of a 200 C LC parallel resonant circuit

    NASA Technical Reports Server (NTRS)

    Baumann, Eric D.; Hammoud, Ahmad N.

    1995-01-01

    Research efforts are currently underway at the NASA Lewis Research Center to design and demonstrate an inverter capable of operating with a baseplate temperature of 200 C. In support of this project, various electrical components including capacitors, inductors, transformers, cables, and semiconductor switches are being developed or evaluated for integration into the inverter. In this work, a parallel LC resonant circuit was constructed and evaluated under simultaneous electrical and thermal stressing. The tests were performed in the temperature range of 25 to 200 C with an applied voltage of up to 90 V, 20 kHz. The individual components were comprised of high temperature film capacitors and powder core inductors developed in-house. The circuit was characterized in terms of the component currents and case temperatures as well as frequency of resonance as a function of applied bias and temperature. The results obtained, which have indicated good functional stability up to 200 C, are presented and discussed.

  14. Regulation of miR-200c by Nuclear Receptors PPARα, LRH-1 and SHP

    PubMed Central

    Zhang, Yuxia; Yang, Zhihong; Whitby, Richard; Wang, Li

    2011-01-01

    We investigated regulation of miR-200c expression by nuclear receptors. Ectopic expression of miR-200c inhibited MHCC97H cell migration, which was abrogated by the synergistic effects of PPARα and LRH-1 siRNAs. The expression of miR-200c was decreased by PPARα/LRH-1 siRNAs and increased by SHP siRNAs, and overexpression of the receptors reversed the effects of their respective siRNAs. SHP siRNAs also drastically enhanced the ability of the LRH-1 agonist RJW100 to induce miR-200c and downregulate ZEB1 and ZEB2 proteins. Co-expression of PPARα and LRH-1 moderately transactivated the miR-200c promoter, which was repressed by SHP co-expression. RJW100 caused strong activation of the miR-200c promoter. This is the first report to demonstrate that miR-200c expression is controlled by nuclear receptors. PMID:22100809

  15. MiR-200c promotes bladder cancer cell migration and invasion by directly targeting RECK

    PubMed Central

    Cheng, Yidong; Zhang, Xiaolei; Li, Peng; Yang, Chengdi; Tang, Jinyuan; Deng, Xiaheng; Yang, Xiao; Tao, Jun; Lu, Qiang; Li, Pengchao

    2016-01-01

    Background Increasing evidence suggests that the dysregulation of certain microRNAs plays an important role in tumorigenesis and metastasis. MiR-200c exhibits a disordered expression in many tumors and presents dual roles in bladder cancer (BC). Therefore, the definite role of miR-200c in BC needs to be investigated further. Materials and methods Quantitative reverse transcription polymerase chain reaction was used to assess miR-200c expression. Cell invasion and migration were evaluated using wound healing and transwell assays. The luciferase reporter assay was used to identify the direct target of miR-200c. The expression of reversion-inducing cysteine-rich protein with kazal motifs (RECK) in BC tissues and adjacent nontumor tissues, as well as in BC cell lines, was detected through quantitative reverse transcription polymerase chain reaction, Western blot assay, and immunohistochemistry. Results The miR-200c expression was significantly upregulated in the BC tissues compared with the adjacent nontumor tissues. The downregulation of miR-200c significantly inhibited cell migration and invasion in the BC cell lines. The luciferase reporter assay showed that RECK was a direct target of miR-200c. The knockdown of RECK in the BC cell lines treated with anti-miR-200c elevated the previously attenuated cell migration and invasion. Conclusion Our findings indicated that miR-200c functions as oncogenes in BC and may provide a novel therapeutic strategy for the treatment of BC. PMID:27574450

  16. Circulating miR-200c as a diagnostic and prognostic biomarker for gastric cancer

    PubMed Central

    2012-01-01

    Background MicroRNAs are aberrantly expressed and correlate with tumourigenesis and the progression of solid tumours. The miR-200 family determines the epithelial phenotype of cancer cells and regulates invasiveness and migration. Thus, we hypothesised that the quantitative detection of the miR-200 family as epithelial-specific microRNAs in the blood could be a useful clinical biomarker for gastric cancer (GC). Methods We initially validated the expression levels of miR-200a, 200b, 200c and 141 in GC cell lines (n = 2) and blood from healthy controls (n = 19) using real-time quantitative reverse transcription PCR (qRT-PCR). The microarray expression profiles of the miR-200 family in 160 paired samples of non-tumour gastric mucosae and GC were downloaded through ArrayExpress and analysed. MiR-200c was selected for clinical validation. The qRT-PCR prospective assessment of miR-200c was performed using 67 blood samples (52 stage I-IV GC patients and 15 controls); the area under the receiver operating characteristic curve (AUC-ROC) was estimated. The Kaplan-Meier and Breslow-Wilcoxon tests were used to assess the correlation of miR-200c with overall and progression-free survival (OS and PFS). Multivariate analyses were performed using the Cox model. Results The miR-200c blood expression levels in GC patients were significantly higher than in normal controls (p = 0.018). The AUC-ROC was 0.715 (p = 0.012). The sensitivity, specificity and accuracy rates of 65.4%, 100% and 73.1%, respectively, were observed. The levels of miR-200c in the blood above the cutoff defined by the ROC curve was found in 17.6% of stage I-II GC patients, 20.6% of stage III patients and 67.7% of stage IV patients (p < 0.001). The miR-200c expression levels were not associated with clinical or pathological characteristics or recent surgical procedures. There was a correlation (p = 0.016) with the number of lymph node metastases and the increased expression levels of miR-200c

  17. Development of a 1 kW, 200 C Mapham Inventor

    NASA Technical Reports Server (NTRS)

    Hammoud, Ahmad; Gerber, Scott; Bauman, Eric; Overton, Eric; Myers, Ira; Bercaw, Robert

    1995-01-01

    Electronic systems and components are often exposed to high temperature environment in space-based applications, nuclear power facilities, and geothermal energy extraction fields. A key requirement for these systems is, therefore, to withstand the high temperature exposure while maintaining efficient and reliable operation. Efforts were taken to design and develop a high temperature power inverter capable of 200 C operation. A 1 kW, 20 kHz Mapham inverter was designed and evaluated as a function of temperature at different load levels. The inverter system, excluding its input, control, and logic circuits, was characterized at temperatures from ambient to 200 C at 0%, 50%, and 100% resistive loading. With an applied input voltage of 75 VDC, the inverter produced an output of 250 VAC. The results obtained, which indicate good operational characteristics of the inverter up to 200 C, are presented and discussed.

  18. MicroRNA-200c modulates DUSP-1 expression in diabetes-induced cardiac hypertrophy.

    PubMed

    Singh, Gurinder Bir; Raut, Satish K; Khanna, Sanskriti; Kumar, Akhilesh; Sharma, Saurabh; Prasad, Rishikesh; Khullar, Madhu

    2017-01-01

    Mitogen-activated protein kinases (MAPKs) (ERK1/2, JNK, and p38) are upregulated in diabetic cardiomyopathy (DCM). Dual-specific phosphatase-1 (DUSP-1) has been reported to regulate the activity of MAPKs in cardiac hypertrophy; however, the role of DUSP-1 in regulating MAPKs activity in DCM is not known. MicroRNAs have been reported to regulate the expression of several genes in hypertrophied failing hearts. However, little is known about the microRNAs regulating DUSP-1 expression in diabetes-related cardiac hypertrophy. In the present study, we investigated the role of DUSP-1 and miR-200c in diabetes-induced cardiac hypertrophy. DCM was induced in Wistar rats by low-dose Streptozotocin high-fat diet for 12 weeks. Cardiac expression of ERK, p-38, JNK, DUSP-1, miR-200c, and hypertrophy markers (ANP and β-MHC) was studied in DCM in control rats and in high-glucose (HG)-treated rat neonatal cardiomyocytes. miR-200c inhibition was performed to validate DUSP-1 as target. A significant increase in phosphorylated ERK, p38, and JNK was observed in DCM model and in HG-treated cardiomyocytes (p < 0.05). Expression of DUSP-1 was significantly decreased in diabetes group and in HG-treated cardiomyocytes (p < 0.05). Increased expression of miR-200c was observed in DCM model and in HG-treated cardiomyocytes (p < 0.05). Inhibition of miR-200c induces the expression of the DUSP-1 causing decreased expression of phosphorylated ERK, p38, and JNK and attenuated cardiomyocyte hypertrophy in HG-treated cardiomyocytes. miR-200c plays a role in diabetes-associated cardiac hypertrophy by modulating expression of DUSP-1.

  19. Loss of miR-200c: A Marker of Aggressiveness and Chemoresistance in Female Reproductive Cancers

    PubMed Central

    Cochrane, Dawn R.; Howe, Erin N.; Spoelstra, Nicole S.; Richer, Jennifer K.

    2010-01-01

    We focus on unique roles of miR-200c in breast, ovarian, and endometrial cancers. Members of the miR-200 family target ZEB1, a transcription factor which represses E-cadherin and other genes involved in polarity. We demonstrate that the double negative feedback loop between miR-200c and ZEB1 is functional in some, but not all cell lines. Restoration of miR-200c to aggressive cancer cells causes a decrease in migration and invasion. These effects are independent of E-cadherin status. Additionally, we observe that restoration of miR-200c to ovarian cancer cells causes a decrease in adhesion to laminin. We have previously reported that reintroduction of miR-200c to aggressive cells that lack miR-200c expression restores sensitivity to paclitaxel. We now prove that this ability is a result of direct targeting of class III beta-tubulin (TUBB3). Introduction of a TUBB3 expression construct lacking the miR-200c target site into cells transfected with miR-200c mimic results in no change in sensitivity to paclitaxel. Lastly, we observe a decrease in proliferation in cells transfected with miR-200c mimic, and cells where ZEB1 is knocked down stably, demonstrating that the ability of miR-200c to enhance sensitivity to paclitaxel is not due to an increased proliferation rate. PMID:20049172

  20. Prognostic Value and Clinicopathology Significance of MicroRNA-200c Expression in Cancer: A Meta-Analysis

    PubMed Central

    Xu, Jing; Zhu, Weikang; Li, Yan; Yu, Yongchun

    2015-01-01

    MiR-200c has been shown to be related to cancer formation and progression. However, the prognostic and clinicopathologic significance of miR-200c expression in cancer remain inconclusive. We carried out this systematic review and meta-analysis to investigate the prognostic value of miR-200c expression in cancer. Pooled hazard ratios (HRs) of miR-200c for overall survival (OS) and progression-free survival (PFS) were calculated to measure the effective value of miR-200c expression on prognosis. The association between miR-200c expression and clinical significance was measured by odds ratios (ORs). Twenty-three studies were included in our meta-analysis. We found that miR-200c was not significantly correlated with OS (HR = 1.41, 95%Cl: 0.95-2.10; P = 0.09) and PFS (HR = 1.12, 95%Cl: 0.68-1.84; P = 0.67) in cancer. In our subgroup analysis, higher expression of miR-200c was significantly associated with poor OS in blood (HR = 2.10, 95%CI: 1.52-2.90, P<0.00001). Moreover, in clinicopathology analysis, miR-200c expression in blood was significantly associated with TNM stage, lymph node metastasis and distant metastasis. MiR-200c may have the potential to become a new blood biomarker to monitor cancer prognosis and progression. PMID:26035744

  1. Lithium based alloy-thionyl chloride cells for applications at temperatures to 200 C

    NASA Astrophysics Data System (ADS)

    Kane, P.; Marincic, N.; Epstein, J.; Lindsey, A.

    A long-life lithium battery for industrial applications at temperatures up to 200 C was developed by combining Li-based alloy anodes with oxyhalide electrolytes. Cathodes were fabricated by rolling the blend of polycarbonomonofluoride, a conductive carbon additive, and a binder, while anodes were fabricated as those used in oxyhalide cells, incorporating a modified anode current collector designed to prevent the formation of 'lithium islands' at the end of discharge; nonwoven glass fiber separators were pretreated to remove excessive binders and lubricants. Various active electrode surface areas were combined with a corresponding thickness of electrodes and separators, matched in capacity. Tests of the high-rate electrode structure, using Li-Mg alloy anode in conjunction with thionyl chloride electrolyte, have demonstrated that the battery with this anode can be used under abusive conditions such as short circuit and external heating (at 175 C). Raising the operating temperature to 200 C did require some modifications of regular cell hardware.

  2. BRCA mutations cause reduction in miR-200c expression in triple negative breast cancer.

    PubMed

    Erturk, Elif; Cecener, Gulsah; Tezcan, Gulcin; Egeli, Unal; Tunca, Berrin; Gokgoz, Sehsuvar; Tolunay, Sahsine; Tasdelen, Ismet

    2015-02-10

    Triple negative breast cancer (TNBC) is the most aggressive and poorly understood subclass of breast cancer (BC). Over the recent years, miRNA expression studies have been providing certain detailed overview that aberrant expression of miRNAs is associated with TNBC. Although TNBC tumors are strongly connected with loss of function of BRCA genes, there is no knowledge about the effect of BRCA mutation status on miRNA expressions in TNBC cases. The aims of this study were to evaluate the expression profile of miRNAs that plays role in TNBC progression and the role of BRCA mutations in their regulation. The expression level of BC associated 13 miRNAs was analyzed in 7 BRCA mutations positive, 6 BRCA mutations negative TNBC cases and 20 non-tumoral tissues using RT-PCR. According to RT2 Profiler PCR Array Data Analysis, let-7a expression was 4.67 fold reduced in TNBCs as compared to normal tissues (P=0.031). In addition, miR-200c expression was 5.75 fold reduced in BRCA mutation positive TNBC tumors (P=0.005). Analysis revealed a negative correlation between miR-200c and VEGFA expressions (r=-468). Thus, miR-200c may be involved in invasion and metastasis in TNBC cases with BRCA mutation. In this study we provide the knowledge on the first report of association between microRNA-200c and BRCA mutations in TNBC. Further studies and evaluations are required, but this miRNA may provide novel therapeutic molecular targets for TNBC treatment and new directions for the development of anticancer drugs.

  3. Prognostic Role of MicroRNA-200c-141 Cluster in Various Human Solid Malignant Neoplasms

    PubMed Central

    Li, Xiao-yang; Li, Hui; Bu, Jie; Xiong, Liang; Guo, Hong-bin; Liu, Li-hong; Xiao, Tao

    2015-01-01

    The miR-200 family has emerged recently as a noticeable marker for predicting cancer prognosis and tumor progression. We aimed to review the evidence of miR-200c-141 genomic cluster as prognostic biomarkers in cancers. The results suggested that high level of miR-200c had no significant impact on OS (HR = 1.14 [0.77–1.69], P = 0.501) and DFS/PFS (HR = 0.72 [0.45–1.14], P = 0.161). Stratified analyses revealed that high miR-200c expression was significantly related to poor OS in serum/plasma (HR = 2.12 [1.62–2.77], P = 0.000) but not in tissues (HR = 0.89 [0.58–1.37], P = 0.599). High miR-200c expression was significantly associated with favorable DFS/PFS in tissues (HR = 0.56 [0.43–0.73], P = 0.000) but worse DFS/PFS in serum/plasma (HR = 1.90 [1.08–3.36], P = 0.027). For miR-141, we found that high miR-141 expression predicted no significant impact on OS (HR = 1.18 [0.74–1.88], P = 0.482) but poor DFS/PFS (HR = 1.11 [1.04–1.20], P = 0.003). Similarly, subgroup analyses showed that high miR-141 expression predicted poor OS in serum/plasma (HR = 4.34 [2.30–8.21], P = 0.000) but not in tissues (HR = 1.00 [0.92–1.09], P = 0.093). High miR-141 expression was significantly associated with worse DFS/PFS in tissues (HR = 1.12 [1.04–1.20], P = 0.002) but not in serum/plasma (HR = 0.90 [0.44–1.83], P = 0.771). Our findings indicated that, compared to their tissue counterparts, the expression level of miR-200c and miR-141 in peripheral blood may be more effective for monitoring cancer prognosis. High miR-141 expression was better at predicting tumor progression than survival for malignant tumors. PMID:26556949

  4. Over expression of miR-200c suppresses invasion and restores methotrexate sensitivity in lung cancer A549 cells.

    PubMed

    Shan, Wulin; Zhang, Xiaolei; Li, Ming; Deng, Fang; Zhang, Jing

    2016-11-30

    MicroRNAs have become recognized as key players in the development of malignancy. MiR-200c can function as a tumor suppressor gene. However, the effect of miR-200c on methotrexate resistance remains unclear to date. This study aims to evaluate the function of miR-200c in lung cancer A549 cells. The data presented in our study demonstrated that the expression of miR-200c was down-regulated in methotrexate-resistant A549 cells. Over expression of miR-200c could significantly inhibit cell proliferation, induce G0/G1 cell cycle arrest and induce cell apoptosis. RT-PCR and Western blot assays showed that the expression of P53 and P21 were significantly increased with miR-200c overexpression. These results indicated that over expression of miR-200c might enhance the sensitivity of A549 cells to methotrexate through the P53/P21 pathway. Furthermore, miR-200c overexpression significantly inhibited cell migration and invasion with increasing the expression of E-cad and decreasing the expression of EZH2. In consequence, we provide a mechanism of acquired resistance to methotrexate that is caused by the loss of miR-200c in lung cancer cells. Along with this, our study demonstrates the complex network of microRNA mediated chemoresistance.

  5. Regulation of miR-200c by nuclear receptors PPAR{alpha}, LRH-1 and SHP

    SciTech Connect

    Zhang, Yuxia; Yang, Zhihong; Whitby, Richard; Wang, Li

    2011-12-09

    Highlights: Black-Right-Pointing-Pointer Knockdown of PPAR{alpha} and LRH-1 abolishes miR-200c inhibition of HCC cell migration. Black-Right-Pointing-Pointer SHP represses miR-200c expression via inhibition of the activity of PPAR{alpha} and LRH-1. Black-Right-Pointing-Pointer RJW100 exhibits strong ability to downregulate ZEB1 and ZEB2 proteins. -- Abstract: We investigated regulation of miR-200c expression by nuclear receptors. Ectopic expression of miR-200c inhibited MHCC97H cell migration, which was abrogated by the synergistic effects of PPAR{alpha} and LRH-1 siRNAs. The expression of miR-200c was decreased by PPAR{alpha}/LRH-1 siRNAs and increased by SHP siRNAs, and overexpression of the receptors reversed the effects of their respective siRNAs. SHP siRNAs also drastically enhanced the ability of the LRH-1 agonist RJW100 to induce miR-200c and downregulate ZEB1 and ZEB2 proteins. Co-expression of PPAR{alpha} and LRH-1 moderately transactivated the miR-200c promoter, which was repressed by SHP co-expression. RJW100 caused strong activation of the miR-200c promoter. This is the first report to demonstrate that miR-200c expression is controlled by nuclear receptors.

  6. MicroRNA-200c attenuates tumour growth and metastasis of presumptive head and neck squamous cell carcinoma stem cells.

    PubMed

    Lo, Wen-Liang; Yu, Cheng-Chia; Chiou, Guang-Yuh; Chen, Yi-Wei; Huang, Pin-I; Chien, Chian-Shiu; Tseng, Ling-Ming; Chu, Pen-Yuan; Lu, Kai-Hsi; Chang, Kuo-Wei; Kao, Shou-Yen; Chiou, Shih-Hwa

    2011-03-01

    MicroRNA-200c (miR200c) is emerging as an important regulator of tumourigenicity and cancer metastasis with a strong capacity for inducing epithelial-mesenchymal transitions. However, the role of miR200c in head and neck squamous cell carcinoma (HNSCC) and HNSCC-associated cancer stem cells (HNSCC-CSCs) is unknown. In this study, the expression of miR200c in the regional metastatic lymph node of HNSCC tissues was significantly decreased, but BMI1 expression was increased as compared to parental tumours. Importantly, site-directed mutagenesis with a luciferase reporter assay showed that miR200c targeted the 3' UTR of BMI1 in HNSCC cells. Isolated HNSCC-derived ALDH1(+) /CD44(+) cells displayed CSC-like tumour initiating and radio-resistant properties. The expression levels of miR200c were significantly down-regulated while BMI1 was increased in HNSCC-ALDH1(+) /CD44(+) compared to the other subsets of HNSCC cells. Furthermore, increased miR200c expression or knockdown of BMI1 could significantly inhibit the malignant CSC-like properties of ALDH1(+) /CD44(+) cells. miR200c over-expression further down-regulated the expressions of ZEB1, Snail and N-cadherin, but up-regulated E-cadherin expression in ALDH1(+) /CD44(+) cells. Finally, a xenotransplantion study confirmed that over-expression of miR200c or BMI1 knockdown effectively inhibited the lung metastatic ability and prolonged the survival rate of ALDH1(+) /CD44(+) -transplanted mice. In summary, miR200c negatively modulates the expression of BMI1 but also significantly inhibits the metastatic capability of epithelial-mesenchymal transitions in malignant HNSCC by reducing the expression of BMI1/ZEB1. Restoration of miR200c in HNSCC and CSCs may be a promising therapeutic approach.

  7. A 200 C Universal Gate Driver Integrated Circuit for Extreme Environment Applications

    SciTech Connect

    Tolbert, Leon M; Huque, Mohammad A; Islam, Syed K; Blalock, Benjamin J

    2012-01-01

    High-temperature power converters (dc-dc, dc-ac, etc.) have enormous potential in extreme environment applications, including automotive, aerospace, geothermal, nuclear, and well logging. For successful realization of such high-temperature power conversion modules, the associated control electronics also need to perform at high temperature. This paper presents a silicon-on-insulator (SOI) based high-temperature gate driver integrated circuit (IC) incorporating an on-chip low-power temperature sensor and demonstrating an improved peak output current drive over our previously reported work. This driver IC has been primarily designed for automotive applications, where the underhood temperature can reach 200 C. This new gate driver prototype has been designed and implemented in a 0.8 {micro}m, 2-poly, and 3-metal bipolar CMOS-DMOS (Double-Diffused Metal-Oxide Semiconductor) on SOI process and has been successfully tested for up to 200 C ambient temperature driving a SiC MOSFET and a SiC normally-ON JFET. The salient feature of the proposed universal gate driver is its ability to drive power switches over a wide range of gate turn-ON voltages such as MOSFET (0 to 20 V), normally-OFF JFET (-7 to 3 V), and normally-ON JFET (-20 to 0 V). The measured peak output current capability of the driver is around 5 A and is thus capable of driving several power switches connected in parallel. An ultralow-power on-chip temperature supervisory circuit has also been integrated into the die to safeguard the driver circuit against excessive die temperature ({ge}220 C). This approach utilizes increased diode leakage current at higher temperature to monitor the die temperature. The power consumption of the proposed temperature sensor circuit is below 10 {micro}W for operating temperature up to 200 C.

  8. Switching Characteristics of a 4H-SiC Based Bipolar Junction Transistor to 200 C

    NASA Technical Reports Server (NTRS)

    Niedra, Janis M.

    2006-01-01

    Static curves and resistive load switching characteristics of a 600 V, 4 A rated, SiC-based NPN bipolar power transistor (BJT) were observed at selected temperatures from room to 200 C. All testing was done in a pulse mode at low duty cycle (approx.0.1 percent). Turn-on was driven by an adjustable base current pulse and turn-off was accelerated by a negative base voltage pulse of 7 V. These base drive signals were implemented by 850 V, gated power pulsers, having rise-times of roughly 10 ns, or less. Base charge sweep-out with a 7 V negative pulse did not produce the large reverse base current pulse seen in a comparably rated Si-based BJT. This may be due to a very low charge storage time. The decay of the collector current was more linear than its exponential-like rise. Switching observations were done at base drive currents (I(sub B)) up to 400 mA and collector currents (I(sub C)) up to 4 A, using a 100 Omega non-inductive load. At I(sub B) = 400 mA and I(sub C) = 4 A, turn-on times typically varied from 80 to 94 ns, over temperatures from 23 to 200 C. As expected, lowering the base drive greatly extended the turn-on time. Similarly, decreasing the load current to I(sub C) = 1 A with I(sub B) = 400 mA produced turn-on times as short as 34 ns. Over the 23 to 200 C range, with I(sub B) = 400 mA and I(sub C) = 4 A, turn-off times were in the range of 72 to 84 ns with the 7 V sweep-out.

  9. MiR-200c inhibits autophagy and enhances radiosensitivity in breast cancer cells by targeting UBQLN1.

    PubMed

    Sun, Quanquan; Liu, Tongxin; Yuan, Yawei; Guo, Zhenli; Xie, Guozhu; Du, Shasha; Lin, Xiaoshan; Xu, Zhixin; Liu, Minfeng; Wang, Wei; Yuan, Quan; Chen, Longhua

    2015-03-01

    Radioresistance is a major challenge during the treatment of breast cancer. A further understanding of the mechanisms of radioresistance could provide strategies to address this challenge. In our study, we compared the expression of miR-200c in four distinct breast cancer cell lines: two representative basal cancer cells (MDA-MB-231 and BT549) vs. two representative luminal cancer cells (MCF-7 and BT474). The results revealed practically lower expression of miR-200c in the two basal cancer cell lines and higher expression of miR-200c in luminal cancer cells compared to the normal breast epithelial cell line MCF-10A. Ectopic expression of miR-200c in MDA-MB-231 cells inhibited irradiation-induced autophagy and sensitized the breast cancer cells to irradiation. We also identified UBQLN1 as a direct functional target of miR-200c involved in irradiation-induced autophagy and radioresistance. In 35 human breast cancer tissue samples, we detected an inverse correlation between the expression of miR-200c vs. UBQLN1 and LC3. These results indicate that the identified miR-200c/UBQLN1-mediated autophagy pathway may help to elucidate radioresistance in human breast cancer and might represent a therapeutic strategy.

  10. Static and Switching Characteristics of a 4H-SiC Based BJT to 200 C

    NASA Technical Reports Server (NTRS)

    Niedra, Janis M.; Schwarze, Gene E.

    2006-01-01

    Static curves and resistive load switching characteristics of a 600 V, 4 A rated, SiC-based NPN bipolar power transistor (BJT) were observed at selected temperatures from 23 to 200 C. All testing was done in a pulse mode at low duty cycle (approx. 0.1 percent). Turn-on was driven by an adjustable base current pulse and turn-off was accelerated by a negative base voltage pulse of either 7 or 0.6 V. Switching observations were done at base drive currents (I(sub B)) up to 400 mA and collector currents (I(sub C)) up to 4 A, using a 100 OMEGA non-inductive load. At I(sub B) = 400 mA and I(sub C) = 4 A, turn-on times typically varied from 81 to 97 ns, over temperatures from 23 to 200 C. As expected, lowering the base drive greatly extended the turn-on time. Similarly, decreasing the load current to I(sub C) = 1 A with I(sub B) = 400 mA produced turn-on times as short as 30 ns. Over the 23 to 200 C range, with I(sub B) = 400 mA and I(sub C) = 4 A, turn-off times were in the range of 61 to 77 ns with the 7 V sweep-out and 130 to 150 ns with the 0.6 V sweep-out. At a fixed temperature and I(sub C), the turn-off time decreased slightly with decreasing I(sub B), for I(sub B) sufficient to still provide full turn-on. The ratio of conduction to switching losses is estimated, based on the observed I(sub C) transition times and static curves. An estimate at 200 kHz and a 50 percent duty cycle shows that under practicable conditions the two losses can be comparable. Hence the evidence obtained does not support the occasionally voiced concern of necessarily unacceptably high conduction losses in SiC-based BJTs.

  11. MicroRNA-200c delivered by solid lipid nanoparticles enhances the effect of paclitaxel on breast cancer stem cell

    PubMed Central

    Liu, Jingwen; Meng, Tingting; Yuan, Ming; Wen, Lijuan; Cheng, Bolin; Liu, Na; Huang, Xuan; Hong, Yun; Yuan, Hong; Hu, Fuqiang

    2016-01-01

    Background One of the major obstacles in the treatment of breast cancer is breast cancer stem cells (BCSC) which are resistant to standard chemotherapeutic drugs. It has been proven that microRNA-200c (miR-200c) can restore sensitivity to microtubule-targeting chemotherapeutic drugs by reducing the expression of class III β-tubulin. In this study, combination therapy with miR-200c and paclitaxel (PTX) mediated by lipid nanoparticles was investigated as an alternative strategy against BCSC. Materials and methods A cationic lipid 1,2-dioleoyl-3-trimethylammonium-propane was strategically selected to formulate solid lipid nanoparticles (SLN) for miR-200c delivery. Nanostructured lipid carriers (NLC) with 20 wt% oleic acid were prepared for PTX delivery. Mammospheres, which gained the characteristics of BCSC, were used as a cell model to evaluate the efficiency of combination therapy. Results The cationic SLN could condense anionic miRNA to form SLN/miRNA complexes via charge interactions and could protect miRNA from degradation by ribonuclease. SLN/miR-200c complexes achieved 11.6-fold expression of miR-200c after incubation for 24 hours, compared with that of Lipofectamine™ 2000/miR-200c complexes (*P<0.05). Intracellular drug release assay proved that miRNA can be released from SLN/miRNA complexes efficiently in 12 hours after cellular uptake. After BCSC were transfected with SLN/miR-200c, the expression of class III β-tubulin was effectively downregulated and the cellular cytotoxicity of PTX-loaded NLC (NLC/PTX) against BCSC was enhanced significantly (**P<0.01). Conclusion The results indicated that the cationic SLN could serve as a promising carrier for miRNA delivery. In addition, the combination therapy of miR-200c and PTX revealed a novel therapeutic strategy for the treatment of BCSC. PMID:28003747

  12. Nuclear Melt Glass Dissolution and Secondary Mineral Precipitation at 40 to 200C

    SciTech Connect

    Zavarin, M; Roberts, S; Viani, B; Pawloski, G; Rose, T

    2004-06-14

    Most long-lived radionuclides associated with an underground nuclear test are initially incorporated into melt glass and become part of the hydrologic source term (HST) only upon their release via glass dissolution (Pawloski et al., 2001). As the melt glass dissolves, secondary minerals precipitate. The types of secondary minerals that precipitate influence the water chemistry in and around the melt glass. The secondary minerals also provide a sorption sink to the released radionuclides. The changing water chemistry affects the rate of glass dissolution; it also affects the sorption behavior of the released radionuclides. This complex nature of glass dissolution and its important role in defining the HST requires a thorough understanding of glass dissolution and secondary mineral precipitation. The identity of secondary minerals formed at temperatures from 40 to 200 C are evaluated in this report to assist in that understanding.

  13. Controlled-strain rate tests at very low strain rates of 2618 aluminum at 200 C

    NASA Technical Reports Server (NTRS)

    Ding, J. L.; Lee, S. R.

    1988-01-01

    Constant strain rate tests and constant load creep tests were performed on 2618 aluminum at 200 C. The strain rates used in the constant strain rate tests were 10 to the minus 6, 10 to the minus 7, 10 to the minum 8, and 10 to the minus 9/sec. Due to the fact that the strain rates in both tests were comparable to each other, the similarities between them can therefore be studied. It was concluded that metals are essentially rate sensitive at elevated temperatures. The traditional definition of creep and plasticity used in the classical creep analysis is actually a reflection of the material behavior under different loading conditions. A constitutive equation based on the test data under one loading condition should work well for other loading conditions as long as the strain rates are in the same range as those under which the material constants are determined.

  14. Sevoflurane protects against hepatic ischemia/reperfusion injury by modulating microRNA-200c regulation in mice.

    PubMed

    Wu, Yamou; Gu, Chengyong; Huang, Xiaochen

    2016-12-01

    This present study was aimed to investigate the molecular mechanisms involved in sevoflurane protection of hepatic ischemia-reperfusion (I/R) injury. Firstly, we investigated the protective effects of sevoflurane against hepatic I/R injury. Biochemical analysis results showed that sevoflurane preconditioning significantly protected against hepatic I/R injury by reducing liver enzymes and improving antioxidant defense markers. We also found that sevoflurane attenuates I/R-induced hepatic cell death, by TUNEL staining, DNA fragmentation ELISA and PARP activity determination. Next, In order to find the molecular mechanism of sevoflurane preconditioning in hepatic I/R injury, we poured our attention to microRNAs regulation. We focused on miR-200c, one of microRNAs which screened from the gene expression omnibus (GEO). Furthermore, a hydrogen peroxide (H2O2)-induced oxidative stress apoptosis model was also established to mimic hepatic I/R injury, the effects of MiR-200c was investigated. We observed that MiR-200c inhibition decreased the H2O2-induced apoptosis of hepatic AML-12 cells. And also, ZEB1 is found as a target gene of miR-200c and is involved in H2O2-induced apoptosis. On the other hand, the in vivo model was established to examine whether sevoflurane protect against hepatic IR injury by downregulating MiR-200c. Together with the biochemical tests and apoptosis detection, results showed that over-expression of miR-200c significantly inhibited the protect effect of sevoflurane in Hepatic IR injury. Summarizing, sevoflurane preconditioning seems to ameliorate hepatic I/R injury in mice, mediated by mechanisms that include microRNA 200c down regulation. However, further more studies need to be carried out to verify this point.

  15. Regulation of miR‐200c and miR‐141 by Methylation in Prostate Cancer

    PubMed Central

    Lynch, Seodhna M.; O'Neill, Karla M.; McKenna, Michael M.; Walsh, Colum P.

    2016-01-01

    BACKGROUND In prostate cancer (PCa), abnormal expression of several microRNAs (miRNAs) has been previously reported. Increasing evidence shows that aberrant epigenetic regulation of miRNAs is a contributing factor to their altered expression in cancer. In this study, we investigate whether expression of miR‐200c and miR‐141 in PCa is related to the DNA methylation status of their promoter. METHODS PCR analysis of miR‐200c and miR‐141, and CpG methylation analysis of their common promoter, was performed in PCa cell‐lines and in archived prostate biopsy specimens. The biological significance of miR‐200c and miR‐141 expression in prostate cancer cells was assessed by a series of in vitro bioassays and the effect on proposed targets DNMT3A and TET1/TET3 was investigated. The effect on promoter methylation status in cells treated with demethylating agents was also examined. RESULTS miR‐200c and miR‐141 are both highly elevated in LNCaP, 22RV1, and DU145 cells, but significantly reduced in PC3 cells. This correlates inversely with the methylation status of the miR‐200c/miR‐141 promoter, which is unmethylated in LNCaP, 22RV1, and DU145 cells, but hypermethylated in PC3. In PC3 cells, miR‐200c and miR‐141 expression is subsequently elevated by treatment with the demethylating drug decitabine (5‐aza‐2′deoxycytidine) and by knockdown of DNA methyltransferase 1 (DNMT1), suggesting their expression is regulated by methylation. Expression of miR‐200c and miR‐141 in prostate biopsy tissue was inversely correlated with methylation in promoter CpG sites closest to the miR‐200c/miR‐141 loci. In vitro, over‐expression of miR‐200c in PC3 cells inhibited growth and clonogenic potential, as well as inducing apoptosis. Expression of the genes DNMT3A and TET1/TET3 were down‐regulated by miR‐200c and miR‐141 respectively. Finally, treatment with the soy isoflavone genistein caused demethylation of the promoter CpG sites closest to the mi

  16. Retracted: Glabridin attenuates the migratory and invasive capacity of breast cancer cells by activating microRNA-200c

    PubMed Central

    Ye, Xianqing; Jiang, Fei; Li, Yuan; Mu, Juan; Si, Lu; Wang, Xingxing; Ning, Shilong; Li, Zhong

    2014-01-01

    Current treatments for breast cancer, a common malignancy in human females, are less than satisfactory because of high rates of metastasis. Glabridin (GLA), which acts through the FAK/ROS signaling pathway, has been used as an antioxidant and anti-metastatic agent. However, little is known regarding the effect of microRNA (miRNA) on GLA's anti-metastatic activity. The miRNA-200 family, which is frequently expressed at low levels in triple negative breast cancers, inhibits metastasis by blocking the epithelial–mesenchymal transition. Here, we found that GLA attenuated the migratory and invasive capacity of breast cancer cells by activating miR-200c. GLA induced the mesenchymal–epithelial transition in vitro and in vivo, as determined by increased expression of the epithelial marker, E-cadherin, and decreased expression of the mesenchymal marker, vimentin. Overexpression of miR-200c enhanced the expression of E-cadherin and decreased the expression of vimentin. Furthermore, in MDA-MB-231 and BT-549 breast cancer cells exposed to GLA, knockdown of miR-200c blocked the GLA-induced mesenchymal–epithelial transition and alleviated the GLA-induced inhibition of migration and invasion. Thus, elevation of miR-200c by GLA has considerable therapeutic potential for anti-metastatic therapy for breast cancer patients. PMID:24754877

  17. The role of MicroRNAs miR-200b and miR-200c in TLR4 signaling and NF-κB activation

    PubMed Central

    Wendlandt, Erik B; Graff, Joel W; Gioannini, Theresa L; McCaffrey, Anton P; Wilson, Mary E

    2013-01-01

    Recognition of microbial products by members of the Toll-like receptor (TLR) family initiates intracellular signaling cascades that result in NF-κB activation and subsequent production of inflammatory cytokines. We explored the potential roles of microRNAs (miRNAs) in regulating TLR pathways. A target analysis approach to the TLR4 pathway adaptor molecules identified several putative targets of miR-200a, miR-200b and miR-200c. miRNA mimics were co-transfected with a NF-κB activity reporter plasmid into HEK293 cells stably expressing TLR4 (HEK293-TLR4). Mimics of both miR-200b and miR-200c, but not miR-200a, decreased NF-κB reporter activity in either untreated cells or in cells treated with endotoxin:MD2 as a TLR4 agonist. Transfection of HEK293-TLR4 cells with miR-200b or miR-200c significantly decreased expression of MyD88, whereas TLR4, IRAK-1 and TRAF-6 mRNAs were unaffected. When miR-200b or miR-200c mimics were transfected into the differentiated monocytic THP-1 cell line, the abundance of MyD88 transcripts, as well as LPS-induced expression of the pro-inflammatory molecules IL-6, CXCL9 and TNF-α were diminished. These data define miRNAs miR-200b and miR-200c as factors that modify the efficiency of TLR4 signaling through the MyD88-dependent pathway and can thus affect host innate defenses against microbial pathogens. PMID:22522429

  18. Strength of Hycon 3 HP Be-Cu and other copper alloys from 20 C to 200 C

    NASA Astrophysics Data System (ADS)

    Weggel, Robert J.; Ratka, John O.; Spiegelberg, William D.; Sakai, Yoshikazu

    1994-07-01

    To be suitable for high-performance water-cooled magnets a conductor must have an excellent combination of electrical conductivity and tensile strength at moderately elevated temperatures. We have measured the 0.2% yield and ultimate tensile strengths, elongation and modulus of five copper alloys, in the form of heavily cold-worked strip 0.4 mm to 1.2 mm thick, at temperatures up to 200 C. The alloys are Hycon 3 HP Be-Cu (UNS alloy C17510), a 24% silver-copper being developed by NRIM (Tsukuba, Japan), Glidcop(sup (R)), Zr-Cu and electrolytic tough pitch copper. Be-Cu, Zr-Cu and Ag-Cu all retained strength very well. Be-Cu decreased in U.T.S. only 10% from room temperature to 200 C, Zr-Cu, 15%. For Ag-Cu the decrease was 10% from 20 C to 150 C, and another 10% during the next 50 C. Glidcop weakened 20% by 150 C. So did ETP copper, whose strength then plummeted another 50% by 200 C. Except for Ag-Cu, with its filamentary microstructure, all alloys were isotropic within about 5%. The anisotropy of Ag-Cu was about 12%, with the transverse direction being the stronger.

  19. Correlation between EGFR amplification and the expression of microRNA-200c in primary glioblastoma multiforme.

    PubMed

    Serna, Eva; Lopez-Gines, Concha; Monleon, Daniel; Muñoz-Hidalgo, Lisandra; Callaghan, Robert C; Gil-Benso, Rosario; Martinetto, Horacio; Gregori-Romero, Aurelia; Gonzalez-Darder, Jose; Cerda-Nicolas, Miguel

    2014-01-01

    Extensive infiltration of the surrounding healthy brain tissue is a critical feature in glioblastoma. Several miRNAs have been related to gliomagenesis, some of them related with the EGFR pathway. We have evaluated whole-genome miRNA expression profiling associated with different EGFR amplification patterns, studied by fluorescence in situ hybridization in tissue microarrays, of 30 cases of primary glioblastoma multiforme, whose clinicopathological and immunohistochemical features have also been analyzed. MicroRNA-200c showed a very significant difference between tumors having or not EGFR amplification. This microRNA plays an important role in epithelial-mesenchymal transition, but its implication in the behavior of glioblastoma is largely unknown. With respect to EGFR status our cases were categorized into three groups: high level EGFR amplification, low level EGFR amplification, and no EGFR amplification. Our results showed that microRNA-200c and E-cadherin expression are down-regulated, while ZEB1 is up-regulated, when tumors showed a high level of EGFR amplification. Conversely, ZEB1 mRNA expression levels were significantly lower in the group of tumors without EGFR amplification. Tumors with a low level of EGFR amplification showed ZEB1 expression levels comparable to those detected in the group with a high level of amplification. In this study we provide what is to our knowledge the first report of association between microRNA-200c and EGFR amplification in glioblastomas.

  20. Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells

    SciTech Connect

    Vrba, Lukas; Jensen, Taylor J.; Garbe, James C.; Heimark, Ronald L.; Cress, Anne E.; Dickinson, Sally; Stampfer, Martha R.; Futscher, Bernard W.

    2009-12-23

    BACKGROUND: The microRNA-200 family participates in the maintenance of an epithelial phenotype and loss of its expression can result in epithelial to mesenchymal transition (EMT). Furthermore, the loss of expression of miR-200 family members is linked to an aggressive cancer phenotype. Regulation of the miR-200 family expression in normal and cancer cells is not fully understood. METHODOLOGY/ PRINCIPAL FINDINGS: Epigenetic mechanisms participate in the control of miR-200c and miR-141 expression in both normal and cancer cells. A CpG island near the predicted mir-200c/mir-141 transcription start site shows a striking correlation between miR-200c and miR-141 expression and DNA methylation in both normal and cancer cells, as determined by MassARRAY technology. The CpG island is unmethylated in human miR-200/miR-141 expressing epithelial cells and in miR-200c/miR-141 positive tumor cells. The CpG island is heavily methylated in human miR-200c/miR-141 negative fibroblasts and miR-200c/miR-141 negative tumor cells. Mouse cells show a similar inverse correlation between DNA methylation and miR-200c expression. Enrichment of permissive histone modifications, H3 acetylation and H3K4 trimethylation, is seen in normal miR-200c/miR-141-positive epithelial cells, as determined by chromatin immunoprecipitation coupled to real-time PCR. In contrast, repressive H3K9 dimethylation marks are present in normal miR-200c/miR-141-negative fibroblasts and miR-200c/miR-141 negative cancer cells and the permissive histone modifications are absent. The epigenetic modifier drug, 5-aza-2'-deoxycytidine, reactivates miR-200c/miR-141 expression showing that epigenetic mechanisms play a functional role in their transcriptional control. CONCLUSIONS/ SIGNIFICANCE: We report that DNA methylation plays a role in the normal cell type-specific expression of miR-200c and miR-141 and this role appears evolutionarily conserved, since similar results were obtained in mouse. Aberrant DNA methylation of the

  1. miR-200c Regulation of Metastases in Ovarian Cancer: Potential Role in Epithelial and Mesenchymal Transition

    PubMed Central

    Sulaiman, Siti A.; Ab Mutalib, Nurul-Syakima; Jamal, Rahman

    2016-01-01

    Among the gynecological malignancies, ovarian cancer is the most fatal due to its high mortality rate. Most of the identified cases are epithelial ovarian cancer (EOC) with five distinct subtypes: high-grade serous carcinoma, low-grade serous carcinoma, mucinous carcinoma, endometrioid carcinoma, and clear-cell carcinoma. Lack of an early diagnostic approach, high incidence of tumor relapse and the heterogenous characteristics between each EOC subtypes contribute to the difficulties in developing precise intervention and therapy for the patients. MicroRNAs (miRNAs) are single-stranded RNAs that have been shown to function as tumor suppressors or oncomiRs. The miR-200 family, especially miR-200c, has been shown to be implicated in the metastasis and invasion of ovarian carcinoma due to its functional regulation of epithelial-to-mesenchymal transition (EMT). This mini review is aimed to summarize the recent findings of the miR-200c functional role as well as its validated targets in the metastasis cascade of ovarian cancer, with a focus on EMT regulation. The potential of this miRNA in early diagnosis and its dual expression status are also discussed. PMID:27601996

  2. Effects of miR-200c on the migration and invasion abilities of human prostate cancer Du145 cells and the corresponding mechanism.

    PubMed

    Shi, Runlin; Xiao, Haibing; Yang, Tao; Chang, Lei; Tian, Yuanfeng; Wu, Bolin; Xu, Hua

    2014-12-01

    microRNAs (miRNAs) have played a key role in human tumorigenesis, tumor progression, and metastasis. On the one hand, miRNAs are aberrantly expressed in many types of human cancer; on the other hand, miRNAs can function as tumor suppressors or oncogenes that target many cancer-related genes. This study aimed to investigate the effects of miRNA-200c (miR-200c) on the biological behavior and mechanism of proliferation, migration, and invasion in the prostate cancer cell line Du145. In this study, Du145 cells were transfected with miR-200c mimics or negative control miR-NC by using an X-tremeGENE siRNA transfection reagent. The relative expression of miR-200c was measured by RT-PCR. The proliferation, migration, and invasion abilities of Du145 cells were detected by CCK8 assays, migration assays and invasion assays, respectively. The expressions of ZEB1, E-cadherin, and vimentin were observed by western blot. Results showed that DU145 cells exhibited a high expression of miR-200c compared with immortalized normal prostate epithelial cell RWPE-1. Du145 cells were then transfected with miR-200c mimics and displayed lower abilities of proliferation, migration, and invasion than those transfected with the negative control. The protein levels of ZEB1 and vimentin were expressed at a low extent in Du145 cells, which were transfected with miR-200c mimics; by contrast, E-cadherin was highly expressed. Hence, miR-200c could significantly inhibit the proliferation of the prostate cancer cell line Du145; likewise, miR-200c could inhibit migration and invasion by epithelial-mesenchymal transition.

  3. S-200C

    EPA Pesticide Factsheets

    Technical product bulletin: aka SHEENCLEAN, BILGE CLEAR, OIL GONE, this non-intrusive bioremediation agent (nutrient additive) used in oil spill cleanups is an accelerator for remediation of hydrocarbon spills or leaks in soil or sheen on water.

  4. The electrolyte challenge for a direct methanol-air polymer electrolyte fuel cell operating at temperatures up to 200 C

    NASA Technical Reports Server (NTRS)

    Savinell, Robert; Yeager, Ernest; Tryk, Donald; Landau, Uziel; Wainright, Jesse; Gervasio, Dominic; Cahan, Boris; Litt, Morton; Rogers, Charles; Scherson, Daniel

    1993-01-01

    Novel polymer electrolytes are being evaluated for use in a direct methanol-air fuel cell operating at temperatures in excess of 100 C. The evaluation includes tests of thermal stability, ionic conductivity, and vapor transport characteristics. The preliminary results obtained to date indicate that a high temperature polymer electrolyte fuel cell is feasible. For example, Nafion 117 when equilibrated with phosphoric acid has a conductivity of at least 0.4 Omega(exp -1)cm(exp -1) at temperatures up to 200 C in the presence of 400 torr of water vapor and methanol vapor cross over equivalent to 1 mA/cm(exp 2) under a one atmosphere methanol pressure differential at 135 C. Novel polymers are also showing similar encouraging results. The flexibility to modify and optimize the properties by custom synthesis of these novel polymers presents an exciting opportunity to develop an efficient and compact methanol fuel cell.

  5. The Protective Role of microRNA-200c in Alzheimer's Disease Pathologies Is Induced by Beta Amyloid-Triggered Endoplasmic Reticulum Stress

    PubMed Central

    Wu, Qi; Ye, Xiaoyang; Xiong, Yi; Zhu, Haili; Miao, Jianting; Zhang, Wei; Wan, Jun

    2016-01-01

    MicroRNAs are small non-coding RNAs that repress the expression of their target proteins. The roles of microRNAs in the development of Alzheimer's disease (AD) are not clear. In this study we show that miR-200c represses the expression of PTEN protein. PTEN downregulation by miR-200c supports the survival and differentiation of cultured neurons. AD is a progressive neurodegenerative disease signified by beta amyloid (Aβ) peptide aggregation and deposition. In a mouse model of AD that is induced by APPswe and PS1ΔE9 double transgenes, we found Aβ deposition results in neuronal ER stress that induces miR200c. Pharmacological blockade of ER stress inhibited Aβ-induced miR-200c overexpression in AD brains. MiR-200c was detected in the serum of both AD mice and human AD patients. These findings suggest that miR-200c functions as part of the neuronal cell-intrinsic adaptive machinery, and supports neuronal survival and differentiation in response to Aβ induced ER-stress by downregulating PTEN. PMID:28008308

  6. Overexpression of the microRNA hsa-miR-200c leads to reduced expression of transcription factor 8 and increased expression of E-cadherin.

    PubMed

    Hurteau, Gregory J; Carlson, J Andrew; Spivack, Simon D; Brock, Graham J

    2007-09-01

    MicroRNAs are approximately 22-nucleotide sequences thought to interact with multiple mRNAs resulting in either translational repression or degradation. We previously reported that several microRNAs had variable expression in mammalian cell lines, and we examined one, miR-200c, in more detail. A combination of bioinformatics and quantitative reverse transcription-PCR was used to identify potential targets and revealed that the zinc finger transcription factor transcription factor 8 (TCF8; also termed ZEB1, deltaEF1, Nil-2-alpha) had inversely proportional expression levels to miR-200c. Knockout experiments using anti-microRNA oligonucleotides increased TCF8 levels but with nonspecific effects. Therefore, to investigate target predictions, we overexpressed miR-200c in select cells lines. Ordinarily, the expression level of miR-200c in non-small-cell lung cancer A549 cells is low in contrast to normal human bronchial epithelial cells. Stable overexpression of miR-200c in A549 cells results in a loss of TCF8, an increase in expression of its regulatory target, E-cadherin, and altered cell morphology. In MCF7 (estrogen receptor-positive breast cancer) cells, there is endogenous expression of miR-200c and E-cadherin but TCF8 is absent. Conversely, MDA-MB-231 (estrogen receptor-negative) cells lack detectable miR-200c and E-cadherin (the latter reportedly due to promoter region methylation) but express TCF8. The ectopic expression of miR-200c in this cell line also reduced levels of TCF8, restored E-cadherin expression, and altered cell morphology. Because the down-regulation of E-cadherin is a crucial event in epithelial-to-mesenchymal transition, loss of miR-200c expression could play a significant role in the initiation of an invasive phenotype, and, equally, miR-200c overexpression holds potential for its reversal.

  7. Reduced miR-200b and miR-200c expression contributes to abnormal hepatic lipid accumulation by stimulating JUN expression and activating the transcription of srebp1

    PubMed Central

    Sun, Libo; Lu, Yonggang; Dou, Lin; Huang, Xiuqing; Sun, Mingxiao; Pang, Cheng; Qu, Jing; Liu, Guanghui; Li, Jian

    2016-01-01

    Previous studies indicated that miR-200s participated in IL-6-induced hepatic insulin resistance. However, the role of miR-200s in hepatic lipid accumulation has not been elucidated. Here we found that miR-200b and miR-200c were reduced in the steatotic livers of mice fed a high-fat diet (HFD) and patients with nonalcoholic fatty liver disease. This down-regulation was accompanied by an increase in the expression of lipogenic proteins such as sterol regulatory element-binding protein 1 (SREBP1) and fatty acid synthase (FAS). The suppression of miR-200b and miR-200c in Hep1-6 and NCTC1469 hepatocytes enhanced intracellular triglyceride levels, which were associated with increased SREBP-1 and FAS protein levels. In contrast, the over-expression of miR-200b and miR-200c suppressed lipid accumulation and reduced the expression of SREBP1 and FAS in Hep1-6 and NCTC1469 cells transfected with miR-200b or miR-200c mimics. Importantly, the up-regulation of miR-200b and miR-200c could reverse oleic acid/palmitic acid-induced lipid accumulation in hepatocytes. A luciferase reporter assay identified that miR-200b and miR-200c could directly bind the 3′UTR of jun. JUN activated the transcription of srebp1 to increase lipid accumulation. The data also demonstrated that increased miR-200b and miR-200c expression might be associated with sitagliptin-reduced hepatic lipid accumulation in mice fed a HFD. These findings suggest, for the first time, that reduced miR-200b and miR-200c expression contributes to abnormal hepatic lipid accumulation by stimulating JUN expression and activating the transcription of srebp1. PMID:27166182

  8. Targeting the miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features

    PubMed Central

    Sato, Hiroki; Shien, Kazuhiko; Tomida, Shuta; Okayasu, Kazuhiro; Suzawa, Ken; Hashida, Shinsuke; Torigoe, Hidejiro; Watanabe, Mototsugu; Yamamoto, Hiromasa; Soh, Junichi; Asano, Hiroaki; Tsukuda, Kazunori; Miyoshi, Shinichiro; Toyooka, Shinichi

    2017-01-01

    MicroRNA (miR)-200 family members (miR-200s) are frequently silenced in advanced cancer and have been implicated in the process of epithelial-to-mesenchymal transition (EMT). We previously reported that miR-200s were silenced through promoter methylation in acquired EGFR-tyrosine kinase inhibitor (TKI) resistant non-small cell lung cancer (NSCLC) cells harboring EMT features. In this study, we examined the functional role of miR-200s in NSCLC cells and investigated a novel approach to overcoming acquired EGFR-TKI resistance. In the analysis of NSCLC cell lines, each of the miR-200s expression-silenced cell lines showed promoter methylation. Significant correlations between miR-200c silencing and several oncogenic pathway alterations, including EMT-changes and LIN28B overexpression, were observed in the database analysis. In addition, EGFR-wild type cell lines had lower miR-200s expression levels than EGFR-mutant cell lines. The introduction of miR-200c using pre-miR-200c caused LIN28B suppression in cells with acquired EGFR-TKI resistance that harbored EMT features. Interestingly, both the introduction of miR-200c and the knockdown of LIN28B produced an antitumor effect in acquired EGFR-TKI resistance cells, whereas these manipulations were not effective in parental cells. The miR-200c/LIN28B axis plays an important role in cells with acquired resistance to EGFR-TKI that harbor EMT features and might be a useful therapeutic target for overcoming resistance. PMID:28084458

  9. Hepatitis C Virus Induced miR200c Down Modulates FAP-1, a Negative Regulator of Src Signaling and Promotes Hepatic Fibrosis

    PubMed Central

    Ramachandran, Sabarinathan; Ilias Basha, Haseeb; Sarma, Nayan J.; Lin, Yiing; Crippin, Jeffrey S.; Chapman, William C.; Mohanakumar, Thalachallour

    2013-01-01

    Hepatitis C virus (HCV) induced liver disease is the leading indication for liver transplantation (LTx). Reinfection and accelerated development of fibrosis is a universal phenomenon following LTx. The molecular events that lead to fibrosis following HCV infection still remains poorly defined. In this study, we determined microRNA (miRNA) and mRNA expression profiles in livers from chronic HCV patients and normals using microarrays. Using Genego software and pathway finder we performed an interactive analysis to identify target genes that are modulated by miRNAs. 22 miRNAs were up regulated (>2 fold) and 35 miRNAs were down regulated (>2fold) compared to controls. Liver from HCV patients demonstrated increased expression of 306 genes (>3 fold) and reduced expression of 133 genes (>3 fold). Combinatorial analysis of the networks modulated by the miRNAs identified regulation of the phospholipase C pathway (miR200c, miR20b, and miR31through cellular proto-oncogene tyrosine-protein kinase Src (cSrc)), response to growth factors and hormones (miR141, miR107 and miR200c through peroxisome proliferator-activated receptor alpha and extracellular-signal-regulated kinases, and regulation of cellular proliferation (miR20b, miR10b, and miR141 through cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1 p21). Real time PCR (RT-PCR) validation of the miRNA in HCV infected livers demonstrated a 3.3 ±0.9 fold increase in miR200c. In vitro transfection of fibroblasts with miR200c resulted in a 2.2 fold reduction in expression of tyrosine-protein phosphatase non-receptor type 13 or FAS associated phosphatase 1 (FAP-1) and 2.3 fold increase in expression of cSrc. miR200c transfection resulted in significant increases in expression of collagen and fibroblast growth factor (2.8 and 3.4 fold, p<0.05). Therefore, we propose that HCV induced increased expression of miR200c can down modulate the expression of FAP1, a critical regulator of Src and MAP kinase pathway that play

  10. Demethylation drug 5-Aza-2′-deoxycytidine-induced upregulation of miR-200c inhibits the migration, invasion and epithelial-mesenchymal transition of clear cell renal cell carcinoma in vitro

    PubMed Central

    JIANG, JUAN; YI, BO; DING, SIQING; SUN, JIAN; CAO, WEI; LIU, MENGZI

    2016-01-01

    The microRNA (miR)-200 family has been found to be involved in the process of mesenchymal-epithelial transition during renal development. Deregulation of miR-200c has been suggested to be involved in clear cell renal cell carcinoma (ccRCC). However, the precise role of miR-200c in the regulation of ccRCC metastasis has not been previously reported. In the present study, it was observed that miR-200c was frequently downregulated in ccRCC tissue compared with matched adjacent normal tissue. The expression of miR-200c was additionally reduced in ccRCC cell lines when compared with levels in normal renal cells. The DNA demethylation drug 5-Aza-2′-deoxycytidine (Aza) was used to treat several ccRCC cell lines, and it was observed that the expression of miR-200c was significantly increased following Aza treatment. Furthermore, treatment with Aza markedly inhibited ccRCC cell invasion and migration, while treatment with miR-200c inhibitor significantly enhanced invasion and migration of ccRCC cells. In addition, Aza treatment significantly promoted expression of E-cadherin and inhibited the expression of N-cadherin, while the inhibition of miR-200c downregulated E-cadherin and upregulated the expression of N-cadherin, suggesting that miR-200c has a suppressive role in epithelial-mesenchymal transition (EMT) of ccRCC cells. In conclusion, it was suggested that demethylation drug Aza-induced upregulation of miR-200c may inhibit migration, invasion and EMT in ccRCC cells. PMID:27123083

  11. Molecular Mechanism of MicroRNA-200c Regulating Transforming Growth Factor-β (TGF-β)/SMAD Family Member 3 (SMAD3) Pathway by Targeting Zinc Finger E-Box Binding Homeobox 1 (ZEB1) in Hypospadias in Rats

    PubMed Central

    Qian, Chong; Dang, Xiangyang; Wang, Xianglin; Xu, Wei; Pang, Guijian; Chen, Yifeng; Liu, Chengbei

    2016-01-01

    Background The aim of this study was to explore effects of microRNA-200c regulating TGF-β/Smad3 pathway by targeting Zeb1 on the occurrence and development of hypospadias and to evaluate the relationship between microRNA-200c and occurrence of hypospadias. Material/Methods Pregnant rats with a gestational age of 12 days were allocated into 2 groups; one received gavage of DEHP-contained soybean oil (1 ml/day, 8 days; Group A) and the other had gavage of normal soybean oil (1 ml/day, 8 days; Group B). Baby rats with hypospadias from Group A were assigned to the model group (n=20) and healthy baby rats from Group B were assigned to the control group (n=20). Real-time quantitative polymerase chain reaction (qRT-PCR), immunohistochemistry and Western blot analysis were performed to detect microRNA-200c, Zeb1, TGF-β, and Smad3 mRNA and protein expressions in the model group (n=20) and the control group (n=20). The relationship between microRNA-200c and Zeb1 was detected using a dual-luciferase reporter gene experiment. After the in vitro intervention experiment in fetal rat penises, Western blot was used to detect the expression of Zeb1, TGF-β, and Smad3. Results In the model group, microRNA-200c was expressed at a low level, and microRNA-200c expression in control group was 2.1 times higher than in the model group (P<0.05). When compared with the control group, mRNA expressions, protein expressions, and positive rates of Zeb1, TGF-β, and Smad3 were higher in the model group (all P<0.01). Luciferase gene report determined that Zeb1 is a target gene of microRNA-200c. The in vitro intervention experiment in fetal rat penises found that a high concentration of microRNA-200c inhibited hypospadias occurrence by suppressing the expression of Zeb1, TGF-β, and Smad3. Conclusions MicroRNA-200c was expressed in hypospadias penis tissues at low levels and was negatively correlated with Zeb1 expression. MicroRNA-200c up-regulated Zeb1 expression to regulate the TGF-β/Smad3

  12. microRNA-200b and microRNA-200c promote colorectal cancer cell proliferation via targeting the reversion-inducing cysteine-rich protein with Kazal motifs.

    PubMed

    Pan, Yi; Liang, Hongwei; Chen, Weixu; Zhang, Hongjie; Wang, Nan; Wang, Feng; Zhang, Suyang; Liu, Yanqing; Zhao, Chihao; Yan, Xin; Zhang, Junfeng; Zhang, Chen-Yu; Gu, Hongwei; Zen, Ke; Chen, Xi

    2015-01-01

    MicroRNA-200b and microRNA-200c (miR-200b/c) are 2 of the most frequently upregulated oncomiRs in colorectal cancer cells. The role of miR-200b/c during colorectal tumorigenesis, however, remains unclear. In the present study, we report that miR-200b/c can promote colorectal cancer cell proliferation via targeting the reversion-inducing cysteine-rich protein with Kazal motifs (RECK). Firstly, bioinformatics analysis predicted RECK as a conserved target of miR-200b/c. By overexpressing or knocking down miR-200b/c in colorectal cancer cells, we experimentally validated that miR-200b/c are direct regulators of RECK. Secondly, an inverse correlation between the levels of miR-200b/c and RECK protein was found in human colorectal cancer tissues and cell lines. Thirdly, we demonstrated that repression of RECK by miR-200b/c consequently triggered SKP2 (S-phase kinase-associated protein 2) elevation and p27(Kip1) (also known as cyclin-dependent kinase inhibitor 1B) degradation in colorectal cancer cells, which eventually promotes cancer cell proliferation. Finally, promoting tumor cell growth by miR-200b/c-targeting RECK was also observed in the xenograft mouse model. Taken together, our results demonstrate that miR-200b/c play a critical role in promoting colorectal tumorigenesis through inhibiting RECK expression and subsequently triggering SKP2 elevation and p27(Kip1) degradation.

  13. 75 FR 27969 - Airworthiness Directives; The Boeing Company Model 737-100 and -200 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-19

    ... cracking and damaged fasteners of certain fuselage frames and stub beams, and corrective actions if... the inboard chord fastener hole of the frame at body station 639, stringer S-16, and corrective... inspections for the repaired or modified frame only. For airplanes on which the modification or repair is...

  14. Chronic treatment of non-small-cell lung cancer cells with gefitinib leads to an epigenetic loss of epithelial properties associated with reductions in microRNA-155 and -200c

    PubMed Central

    Narita, Michiko; Shimura, Eri; Nagasawa, Atsumi; Aiuchi, Toshiki; Suda, Yukari; Hamada, Yusuke; Ikegami, Daigo; Iwasawa, Chizuru; Arakawa, Kazuhiko; Igarashi, Katsuhide; Kuzumaki, Naoko; Yoshioka, Yusuke; Ochiya, Takahiro; Takeshima, Hideyuki; Ushijima, Toshikazu; Narita, Minoru

    2017-01-01

    Background The EGFR tyrosine kinase inhibitor gefitinib is used in therapy for non-small-cell lung cancer (NSCLC). However, its application is limited by resistance-accelerated disease progression, which is accompanied by the epithelial-to-mesenchymal transition (EMT). In the present study, we performed multiple expression analyses of microRNAs (miRNAs) and quantified the expression of several related EMT players in gefitinib-resistant NSCLC cells. Methods and results To establish gefitinib-resistant NSCLC cells, gefitinib-sensitive HCC827 cells, which exhibit an in-frame deletion [E746-A750] in EGFR exon 19, were exposed to gefitinib for at least 1.5 months. Next, to profile “gefitinib-resistant HCC827 (HCC827GR)” cells, which have a secondary T790M mutation in EGFR exon 20, a miRNA array analysis was performed in HCC827 and HCC827GR cells. The greatest differences were seen in the levels of miR-155 and miR-200c, which essentially disappeared in HCC827GR cells. In addition to these reductions, the levels of smad2 and zeb1, which are both key players in EMT and targets for miR-155 and miR-200c, respectively, were dramatically increased in HCC827GR cells. In HCC827GR cells, the expression of epithelial-cadherin (E-cadherin) was greatly reduced with repressive histone modifications, whereas vimentin, which is expressed in mesenchymal cells, was dramatically increased with active histone modifications. In another gefitinib-resistant NSCLC cell line (H1975 cells), similar to the findings in HCC827GR cells, both miR-155 and miR-200c were absent, and the EMT was induced along with epigenetic modifications. Interestingly, the inhibition of both miR-155 and miR-200c in HCC827 cells without gefitinib induced significant increases in smad2 and zeb1 along with a dramatic decrease in E-cadherin and a slight increase in vimentin. Furthermore, although the inhibition of these miRNAs in HCC827 cells decreased gefitinib sensitivity, this dual-inhibition in HCC827 cells without

  15. Fluid-Rock Interactions at the Interface between Reservoir Rock and Cap Rock: An Experimental Case Study Regarding Mineral Trapping at 54 and 200 C

    NASA Astrophysics Data System (ADS)

    Wigand, M. O.; Carey, J. W.; Kaszuba, J. P.; Hollis, W. K.

    2006-12-01

    Geologic sequestration (underground storage) of carbon dioxide (CO2) is the most feasible approach to mitigating CO2-induced global warming while maintaining the current fossil fuel-based economy. Although simple in principle, effective implementation of geologic sequestration will require significant development of the scientific understanding of interactions among injected CO2 (as a supercritical fluid), brine, and the reservoir rock. This paper presents the results of flow-through experiments that simulated a rising plume of supercritical carbon dioxide (SCCO2) interacting at the interface between reservoir rock and cap rock in a brine- saturated aquifer. We performed two high pressure flow-through experiments using powdered limestone and illite-rich shale separated by a frit with a pore size of 10 μm. One experiment was performed under in-situ pressure (2880 psi) and temperature (54°C) conditions of a typical oil reservoir in the Permian Basin. To increase the kinetic rates of the mineral reactions we also performed an experiment at elevated temperatures (200°C) but using the same boundary conditions for other experimental parameters such as pressure, rock samples, fluids, injection rates, and time span. Both experiments were performed over 3263 hours. After the experiment eight disks of equal size representing different reaction zones were cut to investigate the progressive fluid-rock interaction of the reservoir and cap rock with the mixture of SCCO2 and brine. Additionally, fluid samples were frequently collected and their compositions were analyzed using inductively coupled plasma mass spectrometry. At in-situ temperature conditions we determined an enrichment of B, Ba, Cr, Cu, Fe, K, Li, Mg, Na, Ni, Rb, Si, Sr, Ti, Zn, and sulfate in the collected brines, whereas Mn and chloride concentrations were depleted in comparison with the starting composition. Ca and Al showed uneven behavior with changes in enrichment and depletion during the experiment. At 200

  16. A Long-Lived FeIII-(Hydroperoxo) Intermediate in the Active H200C Variant of Homoprotocatechuate 2,3-Dioxygenase: Characterization by Mössbauer, Electron Paramagnetic Resonance, and Density Functional Theory Methods

    PubMed Central

    Meier, Katlyn K.; Rogers, Melanie S.; Kovaleva, Elena G.; Mbughuni, Michael M.; Bominaar, Emile L.; Lipscomb, John D.; Münck, Eckard

    2015-01-01

    The extradiol-cleaving dioxygenase homoprotocatechuate 2,3-dioxygenase (HPCD) binds substrate homoprotocatechuate (HPCA) and O2 sequentially in adjacent ligand sites of the active site FeII. Kinetic and spectroscopic studies of HPCD have elucidated catalytic roles of several active site residues, including the crucial acid base chemistry of His200. In the present study, reaction of the His200Cys (H200C) variant with native substrate HPCA resulted in a decrease in both kcat and the rate constants for the activation steps following O2 binding by > 400 fold. The reaction proceeds to form the correct extradiol product. This slow reaction allowed a long-lived (t1/2 = 1.5 min) intermediate, H200C-HPCAInt1 (Int1), to be trapped. Mössbauer and parallel mode electron paramagnetic resonance (EPR) studies show that Int1 contains an S1 = 5/2 FeIII center coupled to an SR = 1/2 radical to give a ground state with total spin S = 2 (J > 40 cm−1) in Hexch=JS^1⋅S^R. Density functional theory (DFT) property calculations for structural models Int1 is a (HPCA semiquinone•)FeIII(OOH) complex, in which OOH is protonated at the distal O and the substrate hydroxyls are deprotonated. By combining Mössbauer and EPR data of Int1 with DFT calculations, the orientations of the principal axes of the 57Fe electric field gradient and the zero-field splitting (ZFS) tensors (D = 1.6 cm−1, E/D = 0.05) were determined. This information was used to predict hyperfine splittings from bound 17OOH. DFT reactivity analysis suggests that Int1 can evolve from a ferromagnetically coupled FeIII-superoxo precursor by an inner-sphere proton-coupled-electron-transfer process. Our spectroscopic and DFT results suggest that a ferric hydroperoxo species is capable of extradiol catalysis. PMID:26485328

  17. A preliminary study of a wake vortex encounter hazard boundary for a B737-100 airplane

    NASA Technical Reports Server (NTRS)

    Reimer, Heidi M.; Vicroy, Dan D.

    1996-01-01

    A preliminary batch simulation study was conducted to define the wake decay required for a Boeing 737-100 airplane to safely encounter a Boeing 727 wake and land. The baseline six-degree-of-freedom B737 simulation was modified to include a wake model and the strip-theory calculation of the vortex-induced forces and moments. The guidance and control inputs for the airplane were provided by an autoland system. The wake strength and encounter altitude were varied to establish a safe encounter boundary. The wake was positioned such that the desired flight path traversed the core of the port Vortex. Various safe landing criteria were evaluated for defining a safe encounter boundary. A sensitivity study was also conducted to assess the effects of encounter model inaccuracies.

  18. A Numerical Simulation Study to Develop an Acceptable Wake Encounter Boundary for a B737-100 Airplane

    NASA Technical Reports Server (NTRS)

    Vicroy, Dan D.; Nguyen, Truc

    1993-01-01

    The National Aeronautics and Space Administration (NASA) is conducting research with the goal of enabling safe improvements in the capacity of the nation's air transportation system. The wake-vortex upset hazard is an important factor in establishing the minimum safe spacing between aircraft during landing and take-off operations, thus impacting airport capacity. A batch simulation study was conducted to assess the sensitivity of various safe landing criteria in the development of an acceptable wake encounter boundary. A baseline six-degree-of-freedom simulation of a B737-100 airplane was modified to include a wake model and the vortex-induced forces and moments. The guidance and control input for the airplane was provided by an auto-land system. The wake strength and encounter geometry were varied. A sensitivity study was also conducted to assess the effects of encounter modeling methods and accuracy.

  19. Contrôle de la température durant le processus de dégradation d'un acier Z12CNS20 en frottement avec un acier Z200C13

    NASA Astrophysics Data System (ADS)

    Khanafi-Benghalem, N.; Loucif, K.; Benghalem, K.; Boudoukha, H.; Louahdi, R.

    2005-05-01

    La température de contact lors des essais d'usure varie d'une manière spontanée et aléatoire. Cette température de contact dépend essentiellement de la nature du couple des matériaux en contact de la charge et de la vitesse. Cependant la mesure de la température est très difficile à effectuer compte tenu du choix de l'endroit de prise de la température et des phénomènes d'évacuation de la chaleur et de la dissipation de l'énergie. Dans ce travail nous exposons une méthode très simple de mesure de la température et nous étudions par conséquent la variation de la température du Z12CNS20 / Z200C13. Au cours des essais d'usure pour différentes vitesses de glissement, nous montrons en effet que la température augmente d'une manière progressive en fonction de la vitesse puis elle s'élève brutalement au fur et à mesure qu'on se rapproche du point de contact, et enfin nous prouvons par observation métallographique que l'échantillon subit un écoulement plastique provoqué par l'élévation de la température en fonction de la vitesse.

  20. High-lift flow-physics flight experiments on a subsonic civil transport aircraft (B737-100)

    NASA Technical Reports Server (NTRS)

    Vandam, Cornelis P.

    1994-01-01

    As part of the subsonic transport high-lift program, flight experiments are being conducted using NASA Langley's B737-100 to measure the flow characteristics of the multi-element high-lift system at full-scale high-Reynolds-number conditions. The instrumentation consists of hot-film anemometers to measure boundary-layer states, an infra-red camera to detect transition from laminar to turbulent flow, Preston tubes to measure wall shear stress, boundary-layer rakes to measure off-surface velocity profiles, and pressure orifices to measure surface pressure distributions. The initial phase of this research project was recently concluded with two flights on July 14. This phase consisted of a total of twenty flights over a period of about ten weeks. In the coming months the data obtained in this initial set of flight experiments will be analyzed and the results will be used to finalize the instrumentation layout for the next set of flight experiments scheduled for Winter and Spring of 1995. The main goal of these upcoming flights will be: (1) to measure more detailed surface pressure distributions across the wing for a range of flight conditions and flap settings; (2) to visualize the surface flows across the multi-element wing at high-lift conditions using fluorescent mini tufts; and (3) to measure in more detail the changes in boundary-layer state on the various flap elements as a result of changes in flight condition and flap deflection. These flight measured results are being correlated with experimental data measured in ground-based facilities as well as with computational data calculated with methods based on the Navier-Stokes equations or a reduced set of these equations. Also these results provide insight into the extent of laminar flow that exists on actual multi-element lifting surfaces at full-scale high-life conditions. Preliminary results indicate that depending on the deflection angle, the slat and flap elements have significant regions of laminar flow over

  1. Identification of miR-31-5p, miR-141-3p, miR-200c-3p, and GLT1 as human liver aging markers sensitive to donor-recipient age-mismatch in transplants.

    PubMed

    Capri, Miriam; Olivieri, Fabiola; Lanzarini, Catia; Remondini, Daniel; Borelli, Vincenzo; Lazzarini, Raffaella; Graciotti, Laura; Albertini, Maria Cristina; Bellavista, Elena; Santoro, Aurelia; Biondi, Fiammetta; Tagliafico, Enrico; Tenedini, Elena; Morsiani, Cristina; Pizza, Grazia; Vasuri, Francesco; D'Errico, Antonietta; Dazzi, Alessandro; Pellegrini, Sara; Magenta, Alessandra; D'Agostino, Marco; Capogrossi, Maurizio C; Cescon, Matteo; Rippo, Maria Rita; Procopio, Antonio Domenico; Franceschi, Claudio; Grazi, Gian Luca

    2017-04-01

    To understand why livers from aged donors are successfully used for transplants, we looked for markers of liver aging in 71 biopsies from donors aged 12-92 years before transplants and in 11 biopsies after transplants with high donor-recipient age-mismatch. We also assessed liver function in 36 age-mismatched recipients. The major findings were the following: (i) miR-31-5p, miR-141-3p, and miR-200c-3p increased with age, as assessed by microRNAs (miRs) and mRNA transcript profiling in 12 biopsies and results were validated by RT-qPCR in a total of 58 biopsies; (ii) telomere length measured by qPCR in 45 samples showed a significant age-dependent shortage; (iii) a bioinformatic approach combining transcriptome and miRs data identified putative miRs targets, the most informative being GLT1, a glutamate transporter expressed in hepatocytes. GLT1 was demonstrated by luciferase assay to be a target of miR-31-5p and miR-200c-3p, and both its mRNA (RT-qPCR) and protein (immunohistochemistry) significantly decreased with age in liver biopsies and in hepatic centrilobular zone, respectively; (iv) miR-31-5p, miR-141-3p and miR-200c-3p expression was significantly affected by recipient age (older environment) as assessed in eleven cases of donor-recipient extreme age-mismatch; (v) the analysis of recipients plasma by N-glycans profiling, capable of assessing liver functions and biological age, showed that liver function recovered after transplants, independently of age-mismatch, and recipients apparently 'rejuvenated' according to their glycomic age. In conclusion, we identified new markers of aging in human liver, their relevance in donor-recipient age-mismatches in transplantation, and offered positive evidence for the use of organs from old donors.

  2. 75 FR 16651 - Airworthiness Directives; The Boeing Company Model 747-200C and -200F Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-02

    ... repetitive inspections to find fatigue cracking in the floor panel attachment fastener holes of the upper... initiating certain repetitive inspections. This new AD requires additional repetitive inspections to find... to find fatigue cracking in the permanent fastener holes of the upper chord of certain upper...

  3. 75 FR 19564 - Airworthiness Directives; The Boeing Company Model 737-200, -200C, -300, -400, and- 500 Series...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-15

    ... in the skin, antenna support structure, and surrounding frames and stringers; depending on the... structure, and surrounding frames and stringers; and Internal detailed inspection for any crack or corrosion in the skin, antenna support structure, and surrounding frames and stringers. The initial...

  4. 75 FR 5692 - Airworthiness Directives; The Boeing Company Model 747-200C and -200F Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-04

    ... structural integrity of the affected 7075 series aluminum alloy upper deck floor beam upper chords on... adequate to ensure the structural integrity of the affected 7075 series aluminum alloy upper deck...

  5. 76 FR 12619 - Airworthiness Directives; The Boeing Company 737-200, -200C, -300, -400, and -500 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-08

    ... the skin panels, which could result in sudden fracture and failure of the skin panels of the fuselage... fix fatigue cracking of the skin panels, which could result in sudden fracture and failure of the skin... the skin panels, which could result in sudden fracture and failure of the skin panels of the...

  6. 76 FR 74667 - Airworthiness Directives; The Boeing Company Model 737-200, -200C, -300, -400, and -500 Series...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-01

    ..., which could result in sudden fracture and failure of the fuselage skin panels, and consequent rapid...-milled steps, which could result in sudden fracture and failure of the fuselage skin panels,...

  7. 76 FR 54399 - Airworthiness Directives; The Boeing Company Model 737-200, -200C, -300, -400, and -500 Series...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-01

    ... sudden fracture and failure of the fuselage skin panels, and consequent rapid decompression of the..., which could result in sudden fracture and failure of the fuselage skin panels, and consequent rapid... panels at the chem-milled steps, which could result in sudden fracture and failure of the fuselage...

  8. MicroRNA-200c: A Novel Way to Attack Breast Cancer Metastases by Restoring the Epithelial Phenotype

    DTIC Science & Technology

    2012-02-01

    References [1] Lee RC, Feinbaum RL, Ambros V. The C . elegans heterochronic gene lin- 4 encodes small RNAs with antisense complementarity to lin-14. Cell...involved in developmental timing in C . elegans . Genes Dev 2001;15:2654–9.[24] Hutvagner G, Zamore PD. A microRNA in a multiple-turnover RNAi enzyme...human cells. Science 2005;309:1573–6. [ 42 ] Seggerson K, Tang L, Moss EG. Two genetic circuits repress the Caenorhab- ditis elegans heterochronic gene

  9. Exploring the cell: Sodium (beta-alumina) cupric chloride - Aluminum chloride - Sodium chloride between 136 and 200 C

    NASA Technical Reports Server (NTRS)

    Miller, R. O.

    1975-01-01

    Experiments were done with a molten-salt catholyte (initially CuCl2 in AlCl3-NaCl) separated from molten Na by beta alumina. The open-circuit reduction potentials were 4.3 and 3 volts for Cu++ and Cu+, respectively. High polarization and nonrechargeability characterized the cell's operation. The cell's ohmic resistance during discharge was higher than what would be expected from only the ionic resistance of the beta-alumina.

  10. MicroRNA-200c: A Novel Way to Attack Breast Cancer Metastases by Restoring the Epithelial Phenotype

    DTIC Science & Technology

    2012-12-01

    cancer stem cells with normal stem cells. Cell 138(3):592–603 59. Thomson JM, Newman M, Parker JS, Morin-Kensicki EM, Wright T, Hammond SM (2006...endometrial cancers are a heterogeneous group of poorly differentiated tumors (International Federation of Gynecology and Obstet- rics grade 3 endometrioid

  11. 76 FR 68666 - Airworthiness Directives; The Boeing Company Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-07

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT... (AD) for certain The Boeing Company Model 737-100, -200, -200C, and -300 series airplanes. This proposed AD was prompted by a report from the airplane manufacturer that airplanes were assembled with...

  12. 78 FR 27020 - Airworthiness Directives; The Boeing Company Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-09

    ...-186-AD; Amendment 39-17429; AD 2012-18-13 R1] RIN 2120-AA64 Airworthiness Directives; The Boeing... revising an existing airworthiness directive (AD) for all The Boeing Company Model 737-100, -200, -200C, -300, -400, and -500 series ] airplanes. That AD currently requires repetitive inspections to...

  13. 78 FR 72558 - Airworthiness Directives; The Boeing Company Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-03

    ...-194-AD; Amendment 39-17687; AD 2013-24-13] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for certain The Boeing Company Model 737-100, -200, -200C, -300, -400... airworthiness directive (AD): 2013-24-13 The Boeing Company: Amendment 39-17687; Docket No. FAA-...

  14. 76 FR 38074 - Airworthiness Directives; The Boeing Company Model 747-100, 747-100B, 747-200B, 747-200C, 747...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    ... stretched- upper-deck configuration, as identified in Boeing Alert Service Bulletin 747-53A2303, dated June... is measured from the time of the stretched- upper-deck modification. (i) If no cracking is...

  15. 75 FR 1533 - Airworthiness Directives; The Boeing Company Model 747-200F, 747-200C, 747-400, 747-400D, and 747...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-12

    ... certain fuselage internal structure (i.e., Sections 42 and 46 fuselage frames, upper deck floor beams... (i.e., Section 41 fuselage frames where they connect to upper deck floor beams, and Section 41 fuselage frames between stringers (S-8 and S-12)), and related investigative/corrective actions...

  16. 75 FR 81427 - Airworthiness Directives; The Boeing Company Model 747-200C, -200F, -400, -400D, and -400F Series...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-28

    ...., Washington, DC 20590. FOR FURTHER INFORMATION CONTACT: Nicholas Han, Aerospace Engineer, Airframe Branch, ANM... Han, Aerospace Engineer, Airframe Branch, ANM-120S, FAA, Seattle ACO, 1601 Lind Avenue, SW.,...

  17. 75 FR 13046 - Airworthiness Directives; The Boeing Company Model 747-200C, -200F, -400, -400D, and -400F Series...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-18

    ... procedures for repetitive external surface high frequency eddy current (HFEC), external low frequency eddy..., 2005: At the applicable time specified in Table 1 of this AD, do an external surface high frequency eddy current (HFEC), external low frequency eddy current (LFEC), and internal LFEC inspection,...

  18. 46 CFR 117.200 - Survival craft-general.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Survival craft-general. 117.200 Section 117.200 Shipping... Number and Type of Survival Craft § 117.200 Survival craft—general. (a) Each survival craft required on a... craft they replace. (c) A summary of survival craft requirements is provided in Table 117.200(c)....

  19. 46 CFR 117.200 - Survival craft-general.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Survival craft-general. 117.200 Section 117.200 Shipping... Number and Type of Survival Craft § 117.200 Survival craft—general. (a) Each survival craft required on a... craft they replace. (c) A summary of survival craft requirements is provided in Table 117.200(c)....

  20. 20 CFR 664.205 - How is the “deficient in basic literacy skills” criterion in § 664.200(c)(1) defined and documented?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) Computes or solves problems, reads, writes, or speaks English at or below the 8th grade level on a... to compute or solve problems, read, write, or speak English at a level necessary to function on...

  1. 20 CFR 664.205 - How is the “deficient in basic literacy skills” criterion in § 664.200(c)(1) defined and documented?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... problems, reads, writes, or speaks English at or below the 8th grade level on a generally accepted... problems, read, write, or speak English at a level necessary to function on the job, in the...

  2. 20 CFR 664.205 - How is the “deficient in basic literacy skills” criterion in § 664.200(c)(1) defined and documented?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...) Computes or solves problems, reads, writes, or speaks English at or below the 8th grade level on a... to compute or solve problems, read, write, or speak English at a level necessary to function on...

  3. 20 CFR 664.205 - How is the “deficient in basic literacy skills” criterion in § 664.200(c)(1) defined and documented?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... problems, reads, writes, or speaks English at or below the 8th grade level on a generally accepted... problems, read, write, or speak English at a level necessary to function on the job, in the...

  4. 20 CFR 664.205 - How is the “deficient in basic literacy skills” criterion in § 664.200(c)(1) defined and documented?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...) Computes or solves problems, reads, writes, or speaks English at or below the 8th grade level on a... to compute or solve problems, read, write, or speak English at a level necessary to function on...

  5. Plastic substrates for active matrix liquid crystal display incapable of withstanding processing temperature of over 200 C and method of fabrication

    DOEpatents

    Carey, P.G.; Smith, P.M.; Havens, J.H.; Jones, P.

    1999-01-05

    Bright-polarizer-free, active-matrix liquid crystal displays (AMLCDs) are formed on plastic substrates. The primary components of the display are a pixel circuit fabricated on one plastic substrate, an intervening liquid-crystal material, and a counter electrode on a second plastic substrate. The-pixel circuit contains one or more thin-film transistors (TFTs) and either a transparent or reflective pixel electrode manufactured at sufficiently low temperatures to avoid damage to the plastic substrate. Fabrication of the TFTs can be carried out at temperatures less than 100 C. The liquid crystal material is a commercially made nematic curvilinear aligned phase (NCAP) film. The counter electrode is comprised of a plastic substrate coated with a transparent conductor, such as indium-doped tin oxide (ITO). By coupling the active matrix with NCAP, a high-information content can be provided in a bright, fully plastic package. Applications include any low cost portable electronics containing flat displays where ruggedization of the display is desired. 12 figs.

  6. 200 Deg C Demonstration Transformer Operates Efficiently at 50 kHz

    NASA Technical Reports Server (NTRS)

    Niedra, Janis M.; Schwarze, Gene E. (Technical Monitor)

    2003-01-01

    A compact, high temperature demonstration transformer was constructed, using a moly permalloy powder core and Teflon -insulated copper wire. At 50 kHz and 200 C, this 1:2 ratio transformer is capable of 98 percent efficiency when operating at a specific power of 6.1 kW/kg at 4 kW. This roughly 7 cm diameter transformer has a mass of 0.65 kg. Although Teflon is unstable above 200 C, about the same electrical performance was seen at 250 C. A plot of winding loss versus frequency illustrates the need to control these losses at high frequency.

  7. 75 FR 38007 - Airworthiness Directives; The Boeing Company Model 747-100, 747-100B, 747-100B SUD, 747-200B, 747...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-01

    ..., and 747SP Series Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule... SUD, 747-200B, 747-200C, 747-200F, 747-300, 747-400, 747-400F, 747SR, and 747SP series airplanes. This...). This AD results from reports of duct assemblies in the ECS with burned Boeing Material...

  8. To designate the federal building currently known as Federal Office Building 8, located at 200 C Street Southwest in the District of Columbia, as the "Thomas P. O'Neill, Jr. Federal Building".

    THOMAS, 112th Congress

    Rep. Pelosi, Nancy [D-CA-8

    2012-11-27

    11/29/2012 Received in the Senate. (All Actions) Notes: For further action, see S.3687, which became Public Law 112-237 on 12/28/2012. Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

  9. Flight Test Analysis of the Forces and Moments Imparted on a B737-100 Airplane During Wake Vortex Encounters

    NASA Technical Reports Server (NTRS)

    Roberts, Chistopher L.

    2001-01-01

    Aircraft travel has become a major form of transportation. Several of our major airports are operating near their capacity limit, increasing congestion and delays for travelers. As a result, the National Aeronautics and Space Administration (NASA) has been working in conjunction with the Federal Aviation Administration (FAA), airline operators, and the airline industry to increase airport capacity without sacrificing public safety. One solution to the problem is to increase the number of airports and build new. runways; yet, this solution is becoming increasingly difficult due to limited space. A better solution is to increase the production per runway. This solution increases the possibility that one aircraft will encounter the trailing wake of another aircraft. Hazardous wake vortex encounters occur when an aircraft encounters the wake produced by a heavier aircraft. This heavy-load aircraft produces high-intensity wake turbulence that redistributes the aerodynamic loads of trailing smaller aircraft. This situation is particularly hazardous for smaller aircraft during takeoffs and landings. In order to gain a better understanding of the wake-vortex/aircraft encounter phenomena, NASA Langley Research Center conducted a series of flight tests from 1995 through 1997. These tests were designed to gather data for the development a wake encounter and wake-measurement data set with the accompanying atmospheric state information. This data set is being compiled into a database that can be used by wake vortex researchers to compare with experimental and computational results. The purpose of this research is to derive and implement a procedure for calculating the wake-vortex/aircraft interaction portion of that database by using the data recorded during those flight tests. There were three objectives to this research. Initially, the wake-induced forces and moments from each flight were analyzed based on varying flap deflection angles. The flap setting alternated between 15 and 30 degrees while the separation distance remained constant. This examination was performed to determine if increases in flap deflection would increase or decrease the effects of the wake-induced forces and moments. Next, the wake-induced forces and moments from each flight were analyzed based on separation distances of 1-3 nautical miles. In this comparison, flap deflection was held constant at 30 degrees. The purpose of this study was to determine if increased separation distances reduced the effects of the wake vortex on the aircraft. The last objective compared the wake-induced forces and moments of each flight as it executed a series of maneuvers through the wake-vortex. This analysis was conducted to examine the impact of the wake on the B737 as it traversed the wake horizontally and vertically. Results from the first analysis indicated that there was no difference in wake effect at flap deflections of 15 and 30 degrees. This conclusion is evidenced in the cases of the wake-induced sideforce, rolling moment, and yawing moment. The wake-induced lift, drag, and pitching moment cases yielded less conclusive results. The second analysis compared the wake-induced forces and moments at separation distances of 1-3 nautical miles. Results indicated that there was no significant difference in the wake-induced lift, drag, sideforce, or yawing moment coefficients. The analysis compared the wake-induced forces and moments based on different flight maneuvers. It was found that the wake-induced forces and moments had the greatest impact on out-to-in and in-to-out maneuvers.

  10. Flight Test Analysis of the Forces and Moments Imparted on a B737-100 Aircraft During Wake Vortex Encounters

    NASA Technical Reports Server (NTRS)

    Roberts, Christopher L.; Smith, Sonya T.; Vicroy, Dan D.

    2000-01-01

    Several of our major airports are operating at or near their capacity limit, increasing congestion and delays for travelers. As a result, the National Aeronautics and Space Administration (NASA) has been working in conjunction with the Federal Aviation Administration (FAA), airline operators, and the airline industry to increase airport capacity and safety. As more and more airplanes are placed into the terminal area the probability of encountering wake turbulence is increased. The NASA Langley Research Center conducted a series of flight tests from 1995 through 1997 to develop a wake encounter and wake-measurement data set with the accompanying atmospheric state information. The purpose of this research is to use the data from those flights to compute the wake-induced forced and moments exerted on the aircraft The calculated forces and moments will then be compiled into a database that can be used by wake vortex researchers to compare with experimental and computational results.

  11. 24 CFR 200.200 - What is the Appraiser Roster?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false What is the Appraiser Roster? 200.200 Section 200.200 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Appraiser Roster § 200.200 What is...

  12. CYBER 200 Applications Seminar

    NASA Technical Reports Server (NTRS)

    Gary, J. P. (Compiler)

    1984-01-01

    Applications suited for the CYBER 200 digital computer are discussed. Various areas of application including meteorology, algorithms, fluid dynamics, monte carlo methods, petroleum, electronic circuit simulation, biochemistry, lattice gauge theory, economics and ray tracing are discussed.

  13. Status of EXO-200

    SciTech Connect

    Ackerman, Nicole; /SLAC

    2011-12-06

    EXO-200 is the first phase of the Enriched Xenon Observatory (EXO) experiment, which searches for neutrinoless double beta decay in {sup 136}Xe to measure the mass and probe the Majorana nature of the neutrino. EXO-200 consists of 200 kg of liquid Xe enriched to 80% in {sup 136}Xe in an ultra-low background TPC. Energy resolution is enhanced through the simultaneous collection of scintillation light using Large Area Avalanche Photodiodes (LAAPD's) and ionization charge. It is being installed at the WIPP site in New Mexico, which provides a 2000 meter water-equivalent overburden. EXO-200 will begin taking data in 2009, with the expected two-year sensitivity to the half-life for neutrinoless double beta decay of 6.4 x 10{sup 25} years. According to the most recent nuclear matrix element calculations, this corresponds to an effective Majorana neutrino mass of 0.13 to 0.19 eV. It will also measure the two neutrino mode for the first time in {sup 136}Xe.

  14. Deutsch 100, 200, 300.

    ERIC Educational Resources Information Center

    Manitoba Dept. of Education, Winnipeg.

    Manitoba's curriculum guide for German 100, 200, and 300 is designed to (1) make teachers of these courses aware of the official policy concerning the nature, goals, and objectives of the courses and approved teaching materials, and (2) provide instructional guidelines. The guide provides information about three sets of teaching materials from…

  15. Static and Turn-on Switching Characteristics of 4H-Silicon Carbide SITs to 200 deg C

    NASA Technical Reports Server (NTRS)

    Niedra, Janis M.; Schwarze, Gene E.

    2005-01-01

    Test results are presented for normally-off 4H-SiC Static Induction Transistors (SITs) intended for power switching and are among the first normally-off such devices realized in SiC. At zero gate bias, the gate p-n junction depletion layers extend far enough into the conduction channel to cut off the channel. Application of forward gate bias narrows the depletion regions, opening up the channel to conduction by majority carriers. In the present devices, narrow vertical channels get pinched by depletion regions from opposite sides. Since the material is SiC, the devices are usable at temperatures above 150 C. Static curve and pulse mode switching observations were done at selected temperatures up to 200 C on a device with average static characteristics from a batch of similar devices. Gate and drain currents were limited to about 400 mA and 3.5 A, respectively. The drain voltage was limited to roughly 300 V, which is conservative for this 600 V rated device. At 23 C, 1 kW, or even more, could be pulse mode switched in 65 ns (10 to 90 percent) into a 100 load. But at 200 C, the switching capability is greatly reduced in large part by the excessive gate current required. Severe collapse of the saturated drain-to-source current was observed at 200 C. The relation of this property to channel mobility is reviewed.

  16. Dynamics and plasticity of the epithelial to mesenchymal transition induced by miR-200 family inhibition.

    PubMed

    Haraguchi, Takeshi; Kondo, Masayuki; Uchikawa, Ryo; Kobayashi, Kazuyoshi; Hiramatsu, Hiroaki; Kobayashi, Kyousuke; Chit, Ung Weng; Shimizu, Takanobu; Iba, Hideo

    2016-02-18

    Whereas miR-200 family is known to be involved in the epithelial-to-mesenchymal transition (EMT), a crucial biological process observed in normal and pathological contexts, it has been largely unclear how far the functional levels of these tiny RNAs alone can propagate the molecular events to accomplish this process within several days. By developing a potent inhibitor of miR-200 family members (TuD-141/200c), the expression of which is strictly regulatable by the Tet (tetracycline)-On system, we found using a human colorectal cell line, HCT116, that several direct gene target mRNAs (Zeb1/Zeb2, ESRP1, FN1and FHOD1) of miR-200 family were elevated with distinct kinetics. Prompt induction of the transcriptional suppressors, Zeb1/Zeb2 in turn reduced the expression levels of miR-200c/-141 locus, EpCAM, ESRP1 and E-Cad. The loss of ESRP1 subsequently switched the splicing isoforms of CD44 and p120 catenin mRNAs to mesenchymal type. Importantly, within 9 days after the release from the inhibition of miR-200 family, all of the expression changes in the 14 genes observed in this study returned to their original levels in the epithelial cells. This suggests that the inherent epithelial plasticity is supported by a weak retention of key regulatory gene expression in either the epithelial or mesenchymal states through epigenetic regulation.

  17. Rabbit CD200R binds host CD200 but not CD200-like proteins from poxviruses

    PubMed Central

    Akkaya, Munir; Kwong, Lai-Shan; Akkaya, Erdem; Hatherley, Deborah; Barclay, A. Neil

    2016-01-01

    CD200 is a widely distributed membrane protein that gives inhibitory signals through its receptor (CD200R) on myeloid cells. CD200 has been acquired by herpesviruses where it has been shown to interact with host CD200R and downmodulate the immune system. It has been hypothesized that poxviruses have acquired CD200; but the potential orthologues show less similarity to their hosts. Myxoma virus M141 protein is a potential CD200 orthologue with a potent immune modulatory function in rabbits. Here, we characterized the rabbit CD200, CD200R and tested the CD200-like sequences for binding CD200R. No binding could be detected using soluble recombinant proteins, full length protein expressed on cells or myxoma virus infected cells. Finally, using knockdown models, we showed that the inhibitory effect of M141 on RAW 264.7 cells upon myxoma virus infection is not due to CD200R. We conclude that the rabbit poxvirus CD200-like proteins cause immunomodulation without utilizing CD200R. PMID:26590792

  18. Hanford 200 Areas Development Plan

    SciTech Connect

    Rinne, C.A.; Daly, K.S.

    1993-08-01

    The purpose of the Hanford 200 Areas Development Plan (Development Plan) is to guide the physical development of the 200 Areas (which refers to the 200 East Area, 200 West Area, and 200 Area Corridor, located between the 200 East and 200 West Areas) in accordance with US Department of Energy (DOE) Order 4320.lB (DOE 1991a) by performing the following: Establishing a land-use plan and setting land-use categories that meet the needs of existing and proposed activities. Coordinating existing, 5-year, and long-range development plans and guiding growth in accordance with those plans. Establishing development guidelines to encourage cost-effective development and minimize conflicts between adjacent activities. Identifying site development issues that need further analysis. Integrating program plans with development plans to ensure a logical progression of development. Coordinate DOE plans with other agencies [(i.e., Washington State Department of Ecology (Ecology) and US Environmental Protection Agency (EPA)]. Being a support document to the Hanford Site Development Plan (DOE-RL 1990a) (parent document) and providing technical site information relative to the 200 Areas.

  19. Catch tank inhibitor addition 200-East and 200-West Areas

    SciTech Connect

    Palit, A.N.

    1996-06-21

    Reported is the study of 11 catch tanks in the 200-East Area and the 7 catch tanks in the 200-West Area listed as active. The location, capacity, material of construction, annual total accumulation, annual rain intrusion, waste transfer rate, and access for chemical injection in these tanks are documented. The present and future utilization and isolation plans for the catch tanks are established.

  20. MiR-200 can repress breast cancer metastasis through ZEB1-independent but moesin-dependent pathways.

    PubMed

    Li, X; Roslan, S; Johnstone, C N; Wright, J A; Bracken, C P; Anderson, M; Bert, A G; Selth, L A; Anderson, R L; Goodall, G J; Gregory, P A; Khew-Goodall, Y

    2014-07-31

    The microRNA-200 (miR-200) family has a critical role in regulating epithelial-mesenchymal transition and cancer cell invasion through inhibition of the E-cadherin transcriptional repressors ZEB1 and ZEB2. Recent studies have indicated that the miR-200 family may exert their effects at distinct stages in the metastatic process, with an overall effect of enhancing metastasis in a syngeneic mouse breast cancer model. We find in a xenograft orthotopic model of breast cancer metastasis that ectopic expression of members of the miR-200b/200c/429, but not the miR-141/200a, functional groups limits tumour cell invasion and metastasis. Despite modulation of the ZEB1-E-cadherin axis, restoration of ZEB1 in miR-200b-expressing cells was not able to alter metastatic potential suggesting that other targets contribute to this process. Instead, we found that miR-200b repressed several actin-associated genes, with the knockdown of the ezrin-radixin-moesin family member moesin alone phenocopying the repression of cell invasion by miR-200b. Moesin was verified to be directly targeted by miR-200b, and restoration of moesin in miR-200b-expressing cells was sufficient to alleviate metastatic repression. In breast cancer cell lines and patient samples, the expression of moesin significantly inversely correlated with miR-200 expression, and high levels of moesin were associated with poor relapse-free survival. These findings highlight the context-dependent effects of miR-200 in breast cancer metastasis and demonstrate the existence of a moesin-dependent pathway, distinct from the ZEB1-E-cadherin axis, through which miR-200 can regulate tumour cell plasticity and metastasis.

  1. Physics 200, 300 Interim Guide.

    ERIC Educational Resources Information Center

    Manitoba Dept. of Education, Winnipeg.

    This guide, developed for the physics 200, 300 program in Manitoba, is designed to articulate with previous science courses; provide concepts, processes, and skills which will enable students to continue in physics-related areas; and relate physics to practical applications in everyday life. It includes a program overview (with program goals and…

  2. Chemistry 200, 300 Interim Guide.

    ERIC Educational Resources Information Center

    Manitoba Dept. of Education, Winnipeg.

    This guide, developed for the chemistry 200, 300 program in Manitoba, is designed to articulate with previous science courses, provide concepts, processes, and skills which will enable students to continue in chemistry-related areas, and relate chemistry to practical applications in everyday life. It includes a program overview (with program goals…

  3. Viscosity of multi-component molten nitrate salts : liquidus to 200 degrees C.

    SciTech Connect

    Bradshaw, Robert W.

    2010-03-01

    The viscosity of molten salts comprising ternary and quaternary mixtures of the nitrates of sodium, potassium, lithium and calcium was determined experimentally. Viscosity was measured over the temperature range from near the relatively low liquidus temperatures of he individual mixtures to 200C. Molten salt mixtures that do not contain calcium nitrate exhibited relatively low viscosity and an Arrhenius temperature dependence. Molten salt mixtures that contained calcium nitrate were relatively more viscous and viscosity increased as the roportion of calcium nitrate increased. The temperature dependence of viscosity of molten salts containing calcium nitrate displayed curvature, rather than linearity, when plotted in Arrhenius format. Viscosity data for these mixtures were correlated by the Vogel-Fulcher- ammann-Hesse equation.

  4. Minus 55 to plus 200 deg C 12 bit analog-to-digital converter

    NASA Technical Reports Server (NTRS)

    Smith, L. R.; Prazak, P. R.

    1981-01-01

    A 12 bit successive approximation analog to digital converter that offers moderately high speed precision data conversion at a reasonable level of cost and complexity is studied. The ADCH10HT extends this capability over a temperature range of -55 to +200 C. No missing-code performance is maintained over the entire temperature range. The converter is completely self-contained with internal clock and +10 volt reference. The CMOS devices offer low power dissipation, so that the internal temperature of the hybrid circuit does not rise as much from self heating. In CMOS circuits, pn junction leakage currents are returned to the supplies so that the logic keeps working at temperatures up to 250 C.

  5. Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis

    PubMed Central

    Davalos, V; Moutinho, C; Villanueva, A; Boque, R; Silva, P; Carneiro, F; Esteller, M

    2012-01-01

    Epithelial-mesenchymal (EMT) and mesenchymal-epithelial (MET) transitions occur in the development of human tumorigenesis and are part of the natural history of the process to adapt to the changing microenvironment. In this setting, the miR-200 family is recognized as a master regulator of the epithelial phenotype by targeting ZEB1 and ZEB2, two important transcriptional repressors of the cell adherence (E-cadherin) and polarity (CRB3 and LGL2) genes. Recently, the putative DNA methylation associated inactivation of various miR-200 members has been described in cancer. Herein, we show that the miR-200ba429 and miR-200c141 transcripts undergo a dynamic epigenetic regulation linked to EMT or MET phenotypes in tumor progression. The 5′-CpG islands of both miR-200 loci were found unmethylated and coupled to the expression of the corresponding miRNAs in human cancer cell lines with epithelial features, such as low levels of ZEB1/ZEB2 and high expression of E-cadherin, CRB3 and LGL2, while CpG island hypermethylation-associated silencing was observed in transformed cells with mesenchymal characteristics. The recovery of miR-200ba429 and miR-200c141 expression by stable transfection in the hypermethylated cells restored the epithelial markers and inhibited migration in cell culture and tumoral growth and metastasis formation in nude mice. We also discovered, using both cell culture and animal models, that the miR-200 epigenetic silencing is not an static and fixed process but it can be shifted to hypermethylated or unmethylated 5′-CpG island status corresponding to the EMT and MET phenotypes, respectively. In fact, careful laser microdissection in human primary colorectal tumorigenesis unveiled that in normal colon mucosa crypts (epithelia) and stroma (mesenchyma) already are unmethylated and methylated at these loci, respectively; and that the colorectal tumors undergo selective miR-200 hypermethylation of their epithelial component. These findings indicate that the

  6. 36 CFR 200.5 - Indexes.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Indexes. 200.5 Section 200.5..., AND PROCEDURES Functions and Procedures § 200.5 Indexes. Publication of the indexes described in § 200.... However, copies of the indexes are available for public review in the Forest Service headquarters...

  7. 36 CFR 200.5 - Indexes.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Indexes. 200.5 Section 200.5..., AND PROCEDURES Functions and Procedures § 200.5 Indexes. Publication of the indexes described in § 200.... However, copies of the indexes are available for public review in the Forest Service headquarters...

  8. The microRNA-200 family targets multiple non-small cell lung cancer prognostic markers in H1299 cells and BEAS-2B cells.

    PubMed

    Pacurari, Maricica; Addison, Joseph B; Bondalapati, Naveen; Wan, Ying-Wooi; Luo, Dajie; Qian, Yong; Castranova, Vincent; Ivanov, Alexey V; Guo, Nancy Lan

    2013-08-01

    Lung cancer remains the leading cause of cancer-related mortality for both men and women. Tumor recurrence and metastasis is the major cause of lung cancer treatment failure and death. The microRNA‑200 (miR-200) family is a powerful regulator of the epithelial-mesenchymal transition (EMT) process, which is essential in tumor metastasis. Nevertheless, miR-200 family target genes that promote metastasis in non-small cell lung cancer (NSCLC) remain largely unknown. Here, we sought to investigate whether the microRNA-200 family regulates our previously identified NSCLC prognostic marker genes associated with metastasis, as potential molecular targets. Novel miRNA targets were predicted using bioinformatics tools based on correlation analyses of miRNA and mRNA expression in 57 squamous cell lung cancer tumor samples. The predicted target genes were validated with quantitative RT-PCR assays and western blot analysis following re-expression of miR-200a, -200b and -200c in the metastatic NSCLC H1299 cell line. The results show that restoring miR-200a or miR-200c in H1299 cells induces downregulation of DLC1, ATRX and HFE. Reinforced miR-200b expression results in downregulation of DLC1, HNRNPA3 and HFE. Additionally, miR-200 family downregulates HNRNPR3, HFE and ATRX in BEAS-2B immortalized lung epithelial cells in quantitative RT-PCR and western blot assays. The miR-200 family and these potential targets are functionally involved in canonical pathways of immune response, molecular mechanisms of cancer, metastasis signaling, cell-cell communication, proliferation and DNA repair in Ingenuity pathway analysis (IPA). These results indicate that re-expression of miR-200 downregulates our previously identified NSCLC prognostic biomarkers in metastatic NSCLC cells. These results provide new insights into miR-200 regulation in lung cancer metastasis and consequent clinical outcome, and may provide a potential basis for innovative therapeutic approaches for the treatment of this

  9. The PM-200 lubrication system

    NASA Technical Reports Server (NTRS)

    Sliney, Harold E.

    1991-01-01

    Plasma sprayed composite coating of metal-bonded chromium carbide with additions of silver and thermochemically stable fluorides were previously reported to be lubricative in pin on desk bench tests from room temperature to 900 C. An early coating formulation of this type, designated as PS-200, was successfully tested as a cylinder coating in a Stirling engine at a TRRT of 760 C in a hydrogen atmosphere, and as a backup lubricant for gas bearings to 650 C. A subsequent optimization program has shown that tribological properties are further improved by increasing the solid lubricant content. The improved coating is designated as PS-212. The same powder formulation was used to make free-standing powder metallurgy (PM-212) parts by sintering or hot isostatic pressing. The process is very attractive for making parts that cannot be readily plasma sprayed such as bushings and cylinders that have small bore diameters and/or high length to diameter ratios. The properties of coatings and free-standing parts fabricated from these powders are reviewed.

  10. 49 CFR 200.3 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... railroads for freight transportation. ... 49 Transportation 4 2011-10-01 2011-10-01 false Definitions. 200.3 Section 200.3 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT...

  11. 49 CFR 200.3 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... railroads for freight transportation. ... 49 Transportation 4 2010-10-01 2010-10-01 false Definitions. 200.3 Section 200.3 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT...

  12. 42 CFR 400.200 - General definitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false General definitions. 400.200 Section 400.200 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS INTRODUCTION; DEFINITIONS Definitions § 400.200 General definitions. In this chapter, unless...

  13. 7 CFR 62.200 - Services.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Definitions Service § 62.200 Services. QSVP, under this regulation, provide applicants, the ability to have... 7 Agriculture 3 2010-01-01 2010-01-01 false Services. 62.200 Section 62.200 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE...

  14. 2 CFR 200.2 - Acquisition cost.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Acquisition cost. 200.2 Section 200.2 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT... REQUIREMENTS FOR FEDERAL AWARDS Acronyms and Definitions Acronyms § 200.2 Acquisition cost. Acquisition...

  15. 9 CFR 592.200 - Debarment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Debarment. 592.200 Section 592.200 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION VOLUNTARY INSPECTION OF EGG PRODUCTS Denial of Service § 592.200 Debarment. (a) The following...

  16. 9 CFR 592.200 - Debarment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Debarment. 592.200 Section 592.200 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION VOLUNTARY INSPECTION OF EGG PRODUCTS Denial of Service § 592.200 Debarment. (a) The following...

  17. 9 CFR 592.200 - Debarment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Debarment. 592.200 Section 592.200 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION VOLUNTARY INSPECTION OF EGG PRODUCTS Denial of Service § 592.200 Debarment. (a) The following...

  18. 2 CFR 200.111 - English language.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false English language. 200.111 Section 200.111... REQUIREMENTS FOR FEDERAL AWARDS General Provisions § 200.111 English language. (a) All Federal financial assistance announcements and Federal award information must be in the English language. Applications must...

  19. 2 CFR 200.8 - Budget.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Budget. 200.8 Section 200.8 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET... AWARDS Acronyms and Definitions Acronyms § 200.8 Budget. Budget means the financial plan for the...

  20. 49 CFR 179.200-10 - Welding.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Welding. 179.200-10 Section 179.200-10...-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.200-10 Welding. (a) All joints shall be fusion... § 171.7 of this subchapter). Welding procedures, welders and fabricators shall be approved. (b)...

  1. 2 CFR 200.301 - Performance measurement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Performance measurement. 200.301 Section 200.301 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF... § 200.301 Performance measurement. The Federal awarding agency must require the recipient to use...

  2. 31 CFR 1010.200 - General.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false General. 1010.200 Section 1010.200 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY GENERAL PROVISIONS Programs § 1010.200 General. Each...

  3. 10 CFR 1021.200 - DOE planning.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false DOE planning. 1021.200 Section 1021.200 Energy DEPARTMENT... Decisionmaking § 1021.200 DOE planning. (a) DOE shall provide for adequate and timely NEPA review of DOE... accordance with 40 CFR 1501.2 and this section. In its planning for each proposal, DOE shall include...

  4. 17 CFR 200.552 - NEPA planning.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false NEPA planning. 200.552 Section 200.552 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT... § 200.552 NEPA planning. Where it is reasonably foreseeable by the Commission that it may be required...

  5. 38 CFR 200.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Purpose. 200.1 Section 200.1 Pensions, Bonuses, and Veterans' Relief ARMED FORCES RETIREMENT HOME COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT § 200.1 Purpose. These regulations set out AFRH environmental policy...

  6. 46 CFR 148.200 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 5 2012-10-01 2012-10-01 false Purpose. 148.200 Section 148.200 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DANGEROUS CARGOES CARRIAGE OF BULK SOLID MATERIALS THAT REQUIRE SPECIAL HANDLING Special Requirements for Certain Materials § 148.200 Purpose. This subpart...

  7. 38 CFR 1.200 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false Purpose. 1.200 Section 1.200 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS GENERAL PROVISIONS Referrals of Information Regarding Criminal Violations § 1.200 Purpose. This subpart establishes a duty...

  8. 24 CFR 960.200 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 4 2013-04-01 2013-04-01 false Purpose. 960.200 Section 960.200 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED) OFFICE OF..., AND OCCUPANCY OF, PUBLIC HOUSING Admission § 960.200 Purpose. (a) This subpart states HUD...

  9. 29 CFR 2200.200 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 9 2013-07-01 2013-07-01 false Purpose. 2200.200 Section 2200.200 Labor Regulations... Simplified Proceedings § 2200.200 Purpose. (a) The purpose of the Simplified Proceedings subpart is to.... 554. These procedural rules will be applied to accomplish this purpose. (b) Procedures under...

  10. 43 CFR 17.200 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Purpose. 17.200 Section 17.200 Public... OF THE DEPARTMENT OF THE INTERIOR Nondiscrimination on the Basis of Handicap § 17.200 Purpose. The purpose of this subpart is to implement section 504 of the Rehabilitation Act of 1973 and its...

  11. 2 CFR 200.98 - Unobligated balance.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Unobligated balance. 200.98 Section 200.98... REQUIREMENTS FOR FEDERAL AWARDS Acronyms and Definitions Acronyms § 200.98 Unobligated balance. Unobligated balance means the amount of funds under a Federal award that the non-Federal entity has not obligated....

  12. 28 CFR 5.200 - Registration.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Registration. 5.200 Section 5.200 Judicial Administration DEPARTMENT OF JUSTICE ADMINISTRATION AND ENFORCEMENT OF FOREIGN AGENTS REGISTRATION ACT OF 1938, AS AMENDED § 5.200 Registration. (a) Registration under the Act is accomplished by...

  13. 28 CFR 5.200 - Registration.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Registration. 5.200 Section 5.200 Judicial Administration DEPARTMENT OF JUSTICE ADMINISTRATION AND ENFORCEMENT OF FOREIGN AGENTS REGISTRATION ACT OF 1938, AS AMENDED § 5.200 Registration. (a) Registration under the Act is accomplished by...

  14. 28 CFR 5.200 - Registration.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Registration. 5.200 Section 5.200 Judicial Administration DEPARTMENT OF JUSTICE ADMINISTRATION AND ENFORCEMENT OF FOREIGN AGENTS REGISTRATION ACT OF 1938, AS AMENDED § 5.200 Registration. (a) Registration under the Act is accomplished by...

  15. 28 CFR 5.200 - Registration.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Registration. 5.200 Section 5.200 Judicial Administration DEPARTMENT OF JUSTICE ADMINISTRATION AND ENFORCEMENT OF FOREIGN AGENTS REGISTRATION ACT OF 1938, AS AMENDED § 5.200 Registration. (a) Registration under the Act is accomplished by...

  16. 28 CFR 5.200 - Registration.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Registration. 5.200 Section 5.200 Judicial Administration DEPARTMENT OF JUSTICE ADMINISTRATION AND ENFORCEMENT OF FOREIGN AGENTS REGISTRATION ACT OF 1938, AS AMENDED § 5.200 Registration. (a) Registration under the Act is accomplished by...

  17. 2 CFR 200.474 - Travel costs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Travel costs. 200.474 Section 200.474 Grants... REQUIREMENTS FOR FEDERAL AWARDS Cost Principles General Provisions for Selected Items of Cost § 200.474 Travel costs. (a) General. Travel costs are the expenses for transportation, lodging, subsistence, and...

  18. 17 CFR 200.670 - Compliance procedures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Compliance procedures. 200.670 Section 200.670 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION... in Programs or Activities Conducted by the Securities and Exchange Commission § 200.670...

  19. 2 CFR 200.61 - Internal controls.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Internal controls. 200.61 Section 200.61 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF... REQUIREMENTS FOR FEDERAL AWARDS Acronyms and Definitions Acronyms § 200.61 Internal controls. Internal...

  20. 2 CFR 200.303 - Internal controls.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Internal controls. 200.303 Section 200.303... § 200.303 Internal controls. The non-Federal entity must: (a) Establish and maintain effective internal control over the Federal award that provides reasonable assurance that the non-Federal entity is...

  1. 30 CFR 1217.200 - Audits.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Audits. 1217.200 Section 1217.200 Mineral Resources OFFICE OF NATURAL RESOURCES REVENUE, DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE AUDITS AND INSPECTIONS Coal § 1217.200 Audits. An audit of the accounts and books of operators/lessees...

  2. 30 CFR 1217.200 - Audits.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Audits. 1217.200 Section 1217.200 Mineral Resources OFFICE OF NATURAL RESOURCES REVENUE, DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE AUDITS AND INSPECTIONS Coal § 1217.200 Audits. An audit of the accounts and books of operators/lessees...

  3. 7 CFR 3052.200 - Audit requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Audit requirements. 3052.200 Section 3052.200..., DEPARTMENT OF AGRICULTURE AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Audits § 3052.200 Audit requirements. (a) Audit required. Non-Federal entities that expend $500,000 or more in a year...

  4. 7 CFR 3052.200 - Audit requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Audit requirements. 3052.200 Section 3052.200..., DEPARTMENT OF AGRICULTURE AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Audits § 3052.200 Audit requirements. (a) Audit required. Non-Federal entities that expend $500,000 or more in a year...

  5. 29 CFR 99.200 - Audit requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true Audit requirements. 99.200 Section 99.200 Labor Office of the Secretary of Labor AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Audits § 99.200 Audit requirements. (a) Audit required. Non-Federal entities that expend $300,000 or more in...

  6. 30 CFR 1217.200 - Audits.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Audits. 1217.200 Section 1217.200 Mineral Resources OFFICE OF NATURAL RESOURCES REVENUE, DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE AUDITS AND INSPECTIONS Coal § 1217.200 Audits. An audit of the accounts and books of operators/lessees...

  7. 17 CFR 200.29 - Rules.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false Rules. 200.29 Section 200.29 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Organization and Program Management General Organization § 200.29 Rules....

  8. 17 CFR 200.29 - Rules.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Rules. 200.29 Section 200.29 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Organization and Program Management General Organization § 200.29 Rules....

  9. 17 CFR 200.29 - Rules.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 2 2013-04-01 2013-04-01 false Rules. 200.29 Section 200.29 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Organization and Program Management General Organization § 200.29 Rules....

  10. 2 CFR 200.310 - Insurance coverage.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Insurance coverage. 200.310 Section 200.310... REQUIREMENTS FOR FEDERAL AWARDS Post Federal Award Requirements Property Standards § 200.310 Insurance coverage. The non-Federal entity must, at a minimum, provide the equivalent insurance coverage for real...

  11. 2 CFR 200.24 - Cooperative agreement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Cooperative agreement. 200.24 Section 200.24... REQUIREMENTS FOR FEDERAL AWARDS Acronyms and Definitions Acronyms § 200.24 Cooperative agreement. Cooperative... include: (1) A cooperative research and development agreement as defined in 15 U.S.C. 3710a; or (2)...

  12. 2 CFR 200.64 - Local government.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Local government. 200.64 Section 200.64... REQUIREMENTS FOR FEDERAL AWARDS Acronyms and Definitions Acronyms § 200.64 Local government. Local government means any unit of government within a state, including a: (a) County; (b) Borough; (c) Municipality;...

  13. 40 CFR 272.200 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false 272.200 Section 272.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Arkansas § 272.200...

  14. 40 CFR 272.200 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false 272.200 Section 272.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Arkansas § 272.200...

  15. 49 CFR 200.13 - Publication.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Publication. 200.13 Section 200.13 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION INFORMAL RULES OF PRACTICE FOR PASSENGER SERVICE § 200.13 Publication. (a) General notice of...

  16. 49 CFR 200.13 - Publication.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Publication. 200.13 Section 200.13 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION INFORMAL RULES OF PRACTICE FOR PASSENGER SERVICE § 200.13 Publication. (a) General notice of...

  17. 49 CFR 200.13 - Publication.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Publication. 200.13 Section 200.13 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION INFORMAL RULES OF PRACTICE FOR PASSENGER SERVICE § 200.13 Publication. (a) General notice of...

  18. 49 CFR 200.13 - Publication.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Publication. 200.13 Section 200.13 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION INFORMAL RULES OF PRACTICE FOR PASSENGER SERVICE § 200.13 Publication. (a) General notice of...

  19. 49 CFR 200.13 - Publication.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Publication. 200.13 Section 200.13 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION INFORMAL RULES OF PRACTICE FOR PASSENGER SERVICE § 200.13 Publication. (a) General notice of...

  20. 12 CFR 1807.200 - Applicant eligibility.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 9 2012-01-01 2012-01-01 false Applicant eligibility. 1807.200 Section 1807.200 Banks and Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY CAPITAL MAGNET FUND Eligibility § 1807.200 Applicant eligibility. (a) General requirements. An...

  1. 12 CFR 1807.200 - Applicant eligibility.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 10 2014-01-01 2014-01-01 false Applicant eligibility. 1807.200 Section 1807.200 Banks and Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY CAPITAL MAGNET FUND Eligibility § 1807.200 Applicant eligibility. (a) General requirements. An...

  2. 12 CFR 1807.200 - Applicant eligibility.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Applicant eligibility. 1807.200 Section 1807.200 Banks and Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY CAPITAL MAGNET FUND Eligibility § 1807.200 Applicant eligibility. (a) General requirements. An...

  3. 12 CFR 1807.200 - Applicant eligibility.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 9 2013-01-01 2013-01-01 false Applicant eligibility. 1807.200 Section 1807.200 Banks and Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY CAPITAL MAGNET FUND Eligibility § 1807.200 Applicant eligibility. (a) General requirements. An...

  4. 30 CFR 217.200 - Audits.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Audits. 217.200 Section 217.200 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT AUDITS AND INSPECTIONS Coal § 217.200 Audits. An audit of the accounts and books of operators/lessees for the purpose...

  5. 36 CFR 200.1 - Central organization.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Central organization. 200.1 Section 200.1 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE ORGANIZATION, FUNCTIONS, AND PROCEDURES Organization § 200.1 Central organization. (a) Central office. The national...

  6. 36 CFR 200.1 - Central organization.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 2 2014-07-01 2014-07-01 false Central organization. 200.1 Section 200.1 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE ORGANIZATION, FUNCTIONS, AND PROCEDURES Organization § 200.1 Central organization. (a) Central office. The national...

  7. 36 CFR 200.1 - Central organization.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 2 2013-07-01 2013-07-01 false Central organization. 200.1 Section 200.1 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE ORGANIZATION, FUNCTIONS, AND PROCEDURES Organization § 200.1 Central organization. (a) Central office. The national...

  8. 2 CFR 200.47 - Foreign organization.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Foreign organization. 200.47 Section 200.47... REQUIREMENTS FOR FEDERAL AWARDS Acronyms and Definitions Acronyms § 200.47 Foreign organization. Foreign organization means an entity that is: (a) A public or private organization located in a country other than...

  9. 2 CFR 200.70 - Nonprofit organization.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Nonprofit organization. 200.70 Section 200... REQUIREMENTS FOR FEDERAL AWARDS Acronyms and Definitions Acronyms § 200.70 Nonprofit organization. Nonprofit organization means any corporation, trust, association, cooperative, or other organization, not including...

  10. 17 CFR 200.70 - Business promotions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Business promotions. 200.70 Section 200.70 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.70 Business promotions. A member...

  11. 2 CFR 200.22 - Contract.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Contract. 200.22 Section 200.22 Grants and... AWARDS Acronyms and Definitions Acronyms § 200.22 Contract. Contract means a legal instrument by which a... entity considers it a contract, when the substance of the transaction meets the definition of a...

  12. 2 CFR 200.326 - Contract provisions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Contract provisions. 200.326 Section 200.326... REQUIREMENTS FOR FEDERAL AWARDS Post Federal Award Requirements Procurement Standards § 200.326 Contract provisions. The non-Federal entity's contracts must contain the applicable provisions described in...

  13. 17 CFR 200.506 - Derivative classification.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 2 2012-04-01 2012-04-01 false Derivative classification. 200.506 Section 200.506 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION... Information and Material § 200.506 Derivative classification. Any document that includes...

  14. 17 CFR 200.506 - Derivative classification.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false Derivative classification. 200.506 Section 200.506 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION... Information and Material § 200.506 Derivative classification. Any document that includes...

  15. 17 CFR 200.506 - Derivative classification.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Derivative classification. 200.506 Section 200.506 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION... Information and Material § 200.506 Derivative classification. Any document that includes...

  16. 17 CFR 200.506 - Derivative classification.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 3 2014-04-01 2014-04-01 false Derivative classification. 200.506 Section 200.506 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION... Information and Material § 200.506 Derivative classification. Any document that includes...

  17. 4 CFR 200.16 - Mailing lists.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 4 Accounts 1 2010-01-01 2010-01-01 false Mailing lists. 200.16 Section 200.16 Accounts RECOVERY ACCOUNTABILITY AND TRANSPARENCY BOARD PRIVACY ACT OF 1974 § 200.16 Mailing lists. The Board shall not sell or rent an individual's name and/or address unless such action is specifically authorized by law....

  18. 4 CFR 200.7 - Fees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 4 Accounts 1 2010-01-01 2010-01-01 false Fees. 200.7 Section 200.7 Accounts RECOVERY ACCOUNTABILITY AND TRANSPARENCY BOARD PRIVACY ACT OF 1974 § 200.7 Fees. A fee will not be charged for searching, reviewing, or making corrections to records. A fee for copying will be assessed at the same rate...

  19. 21 CFR 820.200 - Servicing.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Servicing. 820.200 Section 820.200 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES QUALITY SYSTEM REGULATION Servicing § 820.200 Servicing. (a) Where servicing is a specified...

  20. 49 CFR 179.200-7 - Materials.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Materials. 179.200-7 Section 179.200-7 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY...-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.200-7 Materials. (a) Plate material used...

  1. 2 CFR 200.83 - Project cost.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Project cost. 200.83 Section 200.83 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT... REQUIREMENTS FOR FEDERAL AWARDS Acronyms and Definitions Acronyms § 200.83 Project cost. Project cost...

  2. 23 CFR 450.200 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 23 Highways 1 2011-04-01 2011-04-01 false Purpose. 450.200 Section 450.200 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PLANNING AND RESEARCH PLANNING ASSISTANCE AND STANDARDS Statewide Transportation Planning and Programming § 450.200 Purpose. The purpose of this...

  3. 23 CFR 450.200 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 23 Highways 1 2014-04-01 2014-04-01 false Purpose. 450.200 Section 450.200 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PLANNING AND RESEARCH PLANNING ASSISTANCE AND STANDARDS Statewide Transportation Planning and Programming § 450.200 Purpose. The purpose of this...

  4. 23 CFR 450.200 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 23 Highways 1 2012-04-01 2012-04-01 false Purpose. 450.200 Section 450.200 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PLANNING AND RESEARCH PLANNING ASSISTANCE AND STANDARDS Statewide Transportation Planning and Programming § 450.200 Purpose. The purpose of this...

  5. 23 CFR 450.200 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 23 Highways 1 2013-04-01 2013-04-01 false Purpose. 450.200 Section 450.200 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PLANNING AND RESEARCH PLANNING ASSISTANCE AND STANDARDS Statewide Transportation Planning and Programming § 450.200 Purpose. The purpose of this...

  6. 23 CFR 450.200 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Purpose. 450.200 Section 450.200 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PLANNING AND RESEARCH PLANNING ASSISTANCE AND STANDARDS Statewide Transportation Planning and Programming § 450.200 Purpose. The purpose of this...

  7. 40 CFR 5.200 - Application.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Application. 5.200 Section 5.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Coverage § 5.200 Application....

  8. 40 CFR 5.200 - Application.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Application. 5.200 Section 5.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Coverage § 5.200 Application....

  9. 40 CFR 5.200 - Application.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Application. 5.200 Section 5.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Coverage § 5.200 Application....

  10. 40 CFR 5.200 - Application.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Application. 5.200 Section 5.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Coverage § 5.200 Application....

  11. 40 CFR 5.200 - Application.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Application. 5.200 Section 5.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Coverage § 5.200 Application....

  12. 2 CFR 200.319 - Competition.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Competition. 200.319 Section 200.319 Grants... REQUIREMENTS FOR FEDERAL AWARDS Post Federal Award Requirements Procurement Standards § 200.319 Competition. (a) All procurement transactions must be conducted in a manner providing full and open...

  13. 42 CFR 412.200 - General provisions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false General provisions. 412.200 Section 412.200 Public... Costs for Hospitals Located in Puerto Rico § 412.200 General provisions. Beginning with discharges... provisions of subparts A, B, C, F, G, and H of this part apply to hospitals located in Puerto Rico....

  14. 24 CFR 200.61 - Title.

    Code of Federal Regulations, 2010 CFR

    2005-04-01

    ... 24 Housing and Urban Development 2 2005-04-01 2005-04-01 false Title. 200.61 Section 200.61... Requirements for Existing Projects General Requirements § 200.61 Title. (a) Marketable title to the project must be vested in the mortgagor as of the date the mortgage is filed for record. (b) Title evidence...

  15. 24 CFR 200.61 - Title.

    Code of Federal Regulations, 2010 CFR

    2004-04-01

    ... 24 Housing and Urban Development 2 2004-04-01 2004-04-01 false Title. 200.61 Section 200.61... Requirements for Existing Projects General Requirements § 200.61 Title. (a) Marketable title to the project must be vested in the mortgagor as of the date the mortgage is filed for record. (b) Title evidence...

  16. 33 CFR 143.200 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Applicability. 143.200 Section 143.200 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT Mobile Offshore Drilling Units § 143.200 Applicability....

  17. 49 CFR 179.200-10 - Welding.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Welding. 179.200-10 Section 179.200-10... Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.200-10 Welding. (a) All joints... W (IBR, see § 171.7 of this subchapter). Welding procedures, welders and fabricators shall...

  18. 2 CFR 200.63 - Loan.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Loan. 200.63 Section 200.63 Grants and... AWARDS Acronyms and Definitions Acronyms § 200.63 Loan. Loan means a Federal loan or loan guarantee... income. (a) The term “direct loan” means a disbursement of funds by the Federal government to a...

  19. 2 CFR 200.406 - Applicable credits.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Applicable credits. 200.406 Section 200.406... REQUIREMENTS FOR FEDERAL AWARDS Cost Principles Basic Considerations § 200.406 Applicable credits. (a) Applicable credits refer to those receipts or reduction-of-expenditure-type transactions that offset...

  20. 34 CFR 200.52 - LEA improvement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... groups of students under § 200.13(b)(7); and (B) That are consistent with AYP as defined under §§ 200.13 through 200.20; (v) Address— (A) The fundamental teaching and learning needs in the schools of the LEA...) Develop and implement its improvement plan; and (ii) Work with schools needing improvement. (3)...

  1. 42 CFR 483.200 - Statutory basis.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Statutory basis. 483.200 Section 483.200 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED..., Transfers, and Preadmission Screening and Annual Resident Review (PASARR) Determinations § 483.200...

  2. 42 CFR 483.200 - Statutory basis.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Statutory basis. 483.200 Section 483.200 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED..., Transfers, and Preadmission Screening and Annual Resident Review (PASARR) Determinations § 483.200...

  3. 24 CFR 200.76 - Smoke detectors.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Smoke detectors. 200.76 Section 200.76 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... Eligibility Requirements for Existing Projects Property Requirements § 200.76 Smoke detectors. Smoke...

  4. 24 CFR 200.76 - Smoke detectors.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Smoke detectors. 200.76 Section 200.76 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... Eligibility Requirements for Existing Projects Property Requirements § 200.76 Smoke detectors. Smoke...

  5. 24 CFR 200.76 - Smoke detectors.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Smoke detectors. 200.76 Section 200.76 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... Eligibility Requirements for Existing Projects Property Requirements § 200.76 Smoke detectors. Smoke...

  6. 10 CFR 830.200 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Scope. 830.200 Section 830.200 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Safety Basis Requirements § 830.200 Scope. This Subpart establishes safety basis requirements for hazard category 1, 2, and 3 DOE nuclear facilities....

  7. 10 CFR 830.200 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Scope. 830.200 Section 830.200 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Safety Basis Requirements § 830.200 Scope. This Subpart establishes safety basis requirements for hazard category 1, 2, and 3 DOE nuclear facilities....

  8. 10 CFR 830.200 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Scope. 830.200 Section 830.200 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Safety Basis Requirements § 830.200 Scope. This Subpart establishes safety basis requirements for hazard category 1, 2, and 3 DOE nuclear facilities....

  9. 10 CFR 830.200 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Scope. 830.200 Section 830.200 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Safety Basis Requirements § 830.200 Scope. This Subpart establishes safety basis requirements for hazard category 1, 2, and 3 DOE nuclear facilities....

  10. 10 CFR 830.200 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Scope. 830.200 Section 830.200 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Safety Basis Requirements § 830.200 Scope. This Subpart establishes safety basis requirements for hazard category 1, 2, and 3 DOE nuclear facilities....

  11. 27 CFR 200.55 - Content.

    Code of Federal Regulations, 2010 CFR

    1999-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 1999-04-01 1999-04-01 false Content. 200.55 Section 200.55 ALCOHOL, TOBACCO AND OTHER EXCISE TAXES-Continued RULES OF PRACTICE IN PERMIT PROCEEDINGS Hearing Procedure Citations § 200.55 Content. (a) Citation for the suspension, revocation or annulment...

  12. 27 CFR 200.55 - Content.

    Code of Federal Regulations, 2010 CFR

    1997-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 1997-04-01 1997-04-01 false Content. 200.55 Section 200.55 ALCOHOL, TOBACCO AND OTHER EXCISE TAXES-Continued RULES OF PRACTICE IN PERMIT PROCEEDINGS Hearing Procedure Citations § 200.55 Content. (a) Citation for the suspension, revocation or annulment...

  13. 34 CFR 200.54 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... by Local Educational Agencies Lea and School Improvement § 200.54 Qualifications Of Teachers And... 34 Education 1 2010-07-01 2010-07-01 false 200.54 Section 200.54 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION, DEPARTMENT...

  14. 34 CFR 200.43 - Restructuring.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Programs Operated by Local Educational Agencies Lea and School Improvement § 200.43 Restructuring. (a... 34 Education 1 2010-07-01 2010-07-01 false Restructuring. 200.43 Section 200.43 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY...

  15. 48 CFR 902.200 - Definitions clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Definitions clause. 902.200 Section 902.200 Federal Acquisition Regulations System DEPARTMENT OF ENERGY GENERAL DEFINITIONS OF WORDS AND TERMS Definitions Clause 902.200 Definitions clause. As prescribed by FAR subpart 2.2,...

  16. 38 CFR 200.1 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2014-07-01 2014-07-01 false Purpose. 200.1 Section 200.1 Pensions, Bonuses, and Veterans' Relief ARMED FORCES RETIREMENT HOME COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT § 200.1 Purpose. These regulations set out AFRH environmental policy...

  17. 38 CFR 200.3 - Responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Responsibilities. 200.3 Section 200.3 Pensions, Bonuses, and Veterans' Relief ARMED FORCES RETIREMENT HOME COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT § 200.3 Responsibilities. (a) The COO is the AFRH NEPA...

  18. 38 CFR 200.3 - Responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2012-07-01 2012-07-01 false Responsibilities. 200.3 Section 200.3 Pensions, Bonuses, and Veterans' Relief ARMED FORCES RETIREMENT HOME COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT § 200.3 Responsibilities. (a) The COO is the AFRH NEPA...

  19. 38 CFR 200.6 - Public involvement.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2011-07-01 2011-07-01 false Public involvement. 200.6 Section 200.6 Pensions, Bonuses, and Veterans' Relief ARMED FORCES RETIREMENT HOME COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT § 200.6 Public involvement. (a) As part of its system for NEPA...

  20. 38 CFR 200.3 - Responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2014-07-01 2014-07-01 false Responsibilities. 200.3 Section 200.3 Pensions, Bonuses, and Veterans' Relief ARMED FORCES RETIREMENT HOME COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT § 200.3 Responsibilities. (a) The COO is the AFRH NEPA...

  1. 38 CFR 200.7 - Cooperating agencies.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2014-07-01 2014-07-01 false Cooperating agencies. 200.7 Section 200.7 Pensions, Bonuses, and Veterans' Relief ARMED FORCES RETIREMENT HOME COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT § 200.7 Cooperating agencies. (a) Federal agencies...

  2. 38 CFR 200.7 - Cooperating agencies.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2012-07-01 2012-07-01 false Cooperating agencies. 200.7 Section 200.7 Pensions, Bonuses, and Veterans' Relief ARMED FORCES RETIREMENT HOME COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT § 200.7 Cooperating agencies. (a) Federal agencies...

  3. 38 CFR 200.6 - Public involvement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2014-07-01 2014-07-01 false Public involvement. 200.6 Section 200.6 Pensions, Bonuses, and Veterans' Relief ARMED FORCES RETIREMENT HOME COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT § 200.6 Public involvement. (a) As part of its system for NEPA...

  4. 38 CFR 200.1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2011-07-01 2011-07-01 false Purpose. 200.1 Section 200.1 Pensions, Bonuses, and Veterans' Relief ARMED FORCES RETIREMENT HOME COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT § 200.1 Purpose. These regulations set out AFRH environmental policy...

  5. 38 CFR 200.1 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2012-07-01 2012-07-01 false Purpose. 200.1 Section 200.1 Pensions, Bonuses, and Veterans' Relief ARMED FORCES RETIREMENT HOME COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT § 200.1 Purpose. These regulations set out AFRH environmental policy...

  6. 38 CFR 200.3 - Responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2011-07-01 2011-07-01 false Responsibilities. 200.3 Section 200.3 Pensions, Bonuses, and Veterans' Relief ARMED FORCES RETIREMENT HOME COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT § 200.3 Responsibilities. (a) The COO is the AFRH NEPA...

  7. 38 CFR 200.6 - Public involvement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Public involvement. 200.6 Section 200.6 Pensions, Bonuses, and Veterans' Relief ARMED FORCES RETIREMENT HOME COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT § 200.6 Public involvement. (a) As part of its system for NEPA...

  8. 38 CFR 200.7 - Cooperating agencies.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2011-07-01 2011-07-01 false Cooperating agencies. 200.7 Section 200.7 Pensions, Bonuses, and Veterans' Relief ARMED FORCES RETIREMENT HOME COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT § 200.7 Cooperating agencies. (a) Federal agencies...

  9. 38 CFR 200.6 - Public involvement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2012-07-01 2012-07-01 false Public involvement. 200.6 Section 200.6 Pensions, Bonuses, and Veterans' Relief ARMED FORCES RETIREMENT HOME COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT § 200.6 Public involvement. (a) As part of its system for NEPA...

  10. Characterization of 720 and 940 MHz Oscillators with Chip Antenna for Wireless Sensors from Room Temperature to 200 and 250 deg C

    NASA Technical Reports Server (NTRS)

    Scardelletti, Maximilian C.; Ponchak, George E.

    2011-01-01

    Oscillators that operate at 720 and 940 MHz and characterized over a temperature range of 25 C to 200 C and 250 C, respectively, are presented. The oscillators are designed on alumina substrates with typical integrated circuit fabrication techniques. Cree SiC MESFETs, thin film metal-insulator-metal capacitors and spiral inductors, and Johanson miniature chip antennas make-up the circuits. The output power and phase noise are presented as a function of temperature and frequency. Index Terms MESFETS, chip antennas, oscillators SiC alumina.

  11. Evaluation of the use of C-terminal part of the Schistosoma mansoni 200kDa tegumental protein in schistosomiasis diagnosis and vaccine formulation.

    PubMed

    Carvalho, Gardênia Braz Figueiredo de; Pacífico, Lucila Gonçalves Grossi; Pimenta, Deborah Laranjeira Ferreira; Siqueira, Liliane Maria Vidal; Teixeira-Carvalho, Andréa; Coelho, Paulo Marcos Zech; Pinheiro, Carina da Silva; Fujiwara, Ricardo Toshio; Oliveira, Sergio Costa; Fonseca, Cristina Toscano

    2014-04-01

    Schistosoma mansoni tegument is involved in essential functions for parasite survival and represents a target for screening candidates for vaccine and diagnosis. Our group using reverse vaccinology selected six candidates, previously demonstrated by proteomics studies to be expressed in the parasite tegument, among them was Sm200. In this work we have cloned and expressed a recombinant form of Sm200 C-terminal (1069-1520) region. The efficacy of rSm200 (1069-1520) in the diagnosis of schistosomiasis and in the formulation of a vaccine against S. mansoni was assessed respectively in an ELISA based diagnostic assay and immunization protocols in mice. Significant differences between non-infected and acutely infected or chronically infected animals were observed and no cross-recognition was observed with sera from Ascaris suum or Ancylostoma ceylanicum infected mice. rSm200-ELISA test could also discriminate infected individuals from healthy donors not living in endemic area for schistosomiasis but failed to discriminate between individuals from a low endemic area for schistosomiasis known to have positive or negative stools after examination. Recombinant Sm200 also failed to induce protection against schistosomiasis, demonstrating that the C-terminal part of Sm200 is unable to induce protective immune response in mice. Therefore rSm200 (1069-1520)-ELISA represents an important tool to be used in the diagnosis of schistosomiasis.

  12. 15 CFR 970.200 - General.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL REGULATIONS OF THE ENVIRONMENTAL DATA SERVICE DEEP SEABED MINING REGULATIONS FOR EXPLORATION LICENSES Applications § 970.200 General. (a)...

  13. 42 CFR 414.200 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Equipment and Prosthetic and Orthotic Devices § 414.200 Purpose. This subpart implements sections 1834 (a... durable medical equipment and prosthetic and orthotic devices for Medicare beneficiaries....

  14. 42 CFR 414.200 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Equipment and Prosthetic and Orthotic Devices § 414.200 Purpose. This subpart implements sections 1834 (a... durable medical equipment and prosthetic and orthotic devices for Medicare beneficiaries....

  15. 15 CFR 970.200 - General.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL REGULATIONS OF THE ENVIRONMENTAL DATA SERVICE DEEP SEABED MINING REGULATIONS FOR EXPLORATION LICENSES Applications § 970.200 General. (a)...

  16. 24 CFR 200.87 - Mortgage prepayment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and Endorsement... Eligibility Requirements for Existing Projects Mortgage Provisions § 200.87 Mortgage prepayment....

  17. 24 CFR 200.83 - Interest rate.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and Endorsement... Eligibility Requirements for Existing Projects Mortgage Provisions § 200.83 Interest rate. (a) The...

  18. 24 CFR 200.80 - Mortgage form.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and Endorsement... Eligibility Requirements for Existing Projects Mortgage Provisions § 200.80 Mortgage form. The mortgage...

  19. 24 CFR 200.83 - Interest rate.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and Endorsement... Eligibility Requirements for Existing Projects Mortgage Provisions § 200.83 Interest rate. (a) The...

  20. 24 CFR 200.61 - Title.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and Endorsement Generally... Requirements for Existing Projects General Requirements § 200.61 Title. (a) Marketable title to the...

  1. 24 CFR 200.87 - Mortgage prepayment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and Endorsement... Eligibility Requirements for Existing Projects Mortgage Provisions § 200.87 Mortgage prepayment....

  2. 24 CFR 200.62 - Certifications.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and Endorsement... Eligibility Requirements for Existing Projects General Requirements § 200.62 Certifications. Any...

  3. 24 CFR 200.76 - Smoke detectors.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and Endorsement... Eligibility Requirements for Existing Projects Property Requirements § 200.76 Smoke detectors. Smoke...

  4. 24 CFR 200.105 - Mortgagor supervision.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and... Continuing Eligibility Requirements for Existing Projects Regulation of Mortgagors § 200.105...

  5. 24 CFR 200.61 - Title.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and Endorsement Generally... Requirements for Existing Projects General Requirements § 200.61 Title. (a) Marketable title to the...

  6. 24 CFR 200.62 - Certifications.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and Endorsement... Eligibility Requirements for Existing Projects General Requirements § 200.62 Certifications. Any...

  7. 24 CFR 200.46 - Commitment issuance.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and Endorsement... Eligibility Requirements for Existing Projects Commitment Applications § 200.46 Commitment issuance....

  8. 24 CFR 200.10 - Lender requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and Endorsement... Eligibility Requirements for Existing Projects Eligible Mortgagee § 200.10 Lender requirements....

  9. 24 CFR 200.105 - Mortgagor supervision.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and... Continuing Eligibility Requirements for Existing Projects Regulation of Mortgagors § 200.105...

  10. 24 CFR 200.10 - Lender requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and Endorsement... Eligibility Requirements for Existing Projects Eligible Mortgagee § 200.10 Lender requirements....

  11. 24 CFR 200.46 - Commitment issuance.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and Endorsement... Eligibility Requirements for Existing Projects Commitment Applications § 200.46 Commitment issuance....

  12. 24 CFR 200.76 - Smoke detectors.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and Endorsement... Eligibility Requirements for Existing Projects Property Requirements § 200.76 Smoke detectors. Smoke...

  13. 24 CFR 200.80 - Mortgage form.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and Endorsement... Eligibility Requirements for Existing Projects Mortgage Provisions § 200.80 Mortgage form. The mortgage...

  14. 15 CFR 970.200 - General.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL REGULATIONS OF THE ENVIRONMENTAL DATA SERVICE DEEP SEABED MINING REGULATIONS FOR EXPLORATION LICENSES Applications § 970.200 General. (a)...

  15. 15 CFR 970.200 - General.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL REGULATIONS OF THE ENVIRONMENTAL DATA SERVICE DEEP SEABED MINING REGULATIONS FOR EXPLORATION LICENSES Applications § 970.200 General. (a)...

  16. 15 CFR 970.200 - General.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL REGULATIONS OF THE ENVIRONMENTAL DATA SERVICE DEEP SEABED MINING REGULATIONS FOR EXPLORATION LICENSES Applications § 970.200 General. (a)...

  17. 33 CFR 143.200 - Applicability.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT Mobile Offshore Drilling Units § 143.200 Applicability. This subpart applies to mobile offshore drilling units when engaged in OCS activities....

  18. Biomaterial aspects of Interpore-200 porous hydroxyapatite.

    PubMed

    White, E; Shors, E C

    1986-01-01

    Interpore-200 is the product of over 11 years of continuous research and development. It has been investigated at over 25 research centers in a wide variety of animal and human implant settings, including alveolar ridge augmentation, periodontics, and orthognathic reconstructions. The biomaterial aspects of Interpore-200 show the following: Interpore-200 has a highly interconnected, three-dimensional porosity that is uniform and consistent. The hydroxyapatite manufactured from marine corals is biocompatible and nontoxic. Interpore-200 is essentially pure hydroxyapatite, with the balance consisting of tricalcium phosphate. Interpore-200 is approximately 55 to 65 per cent porous with nominal pore diameters of 200 micron. Unlike nonporous materials, Interpore-200 is osteoconductive and results, when placed next to a viable bone, in an advancing front of bone into the implant. From 50 to 88 per cent of the porosity within the implant is filled with woven and lamellar bone within 3 months. Moreover, the surfaces of Interpore-200 are intimately bonded with the bone tissue. The biomechanical properties of Interpore-200 blocks are similar to those of a cancellous bone graft. Once ingrown with vascularized bone tissue, the defect site is, in effect, restored. Interpore-200 adequately matches the elastic properties of bone so that stresses necessary to maintain healthy bone are transmitted throughout the regenerated region. Extensive animal and clinical studies have shown that nonporous implants or implants without interconnected porosity can result in aberrant mineralization, stress shielding, low fatigue strength, and bulk displacement. Hydroxyapatite with interconnected porosity like Interpore-200 reacts differently than materials with limited or no porosity. In animals, Interpore-200 exhibits 0 to 5 per cent biodegradation per year. Moreover, this minimal biodegradation is compensated by regeneration of bone. These studies have now been extended for 4 years. Interpore

  19. 24 CFR 200.425 - Exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Exemptions. 200.425 Section 200.425 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN...

  20. 24 CFR 200.400 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Purpose. 200.400 Section 200.400 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN...

  1. 24 CFR 200.430 - Sanctions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Sanctions. 200.430 Section 200.430 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN...

  2. 24 CFR 200.1 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Purpose. 200.1 Section 200.1 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN...

  3. 21 CFR 58.200 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Purpose. 58.200 Section 58.200 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL GOOD LABORATORY PRACTICE FOR... testing facility which has failed to comply with the requirements of the good laboratory...

  4. 21 CFR 58.200 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Purpose. 58.200 Section 58.200 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL GOOD LABORATORY PRACTICE FOR... testing facility which has failed to comply with the requirements of the good laboratory...

  5. 21 CFR 58.200 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Purpose. 58.200 Section 58.200 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL GOOD LABORATORY PRACTICE FOR... testing facility which has failed to comply with the requirements of the good laboratory...

  6. 21 CFR 58.200 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Purpose. 58.200 Section 58.200 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL GOOD LABORATORY PRACTICE FOR... testing facility which has failed to comply with the requirements of the good laboratory...

  7. 21 CFR 58.200 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Purpose. 58.200 Section 58.200 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL GOOD LABORATORY PRACTICE FOR... testing facility which has failed to comply with the requirements of the good laboratory...

  8. 2 CFR 200.440 - Exchange rates.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Exchange rates. 200.440 Section 200.440 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF... Exchange rates. (a) Cost increases for fluctuations in exchange rates are allowable costs subject to...

  9. 24 CFR 200.78 - Energy conservation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Energy conservation. 200.78 Section... Eligibility Requirements for Existing Projects Property Requirements § 200.78 Energy conservation. Construction, mechanical equipment, and energy and metering selections shall provide cost effective...

  10. 24 CFR 200.78 - Energy conservation.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Energy conservation. 200.78 Section... Eligibility Requirements for Existing Projects Property Requirements § 200.78 Energy conservation. Construction, mechanical equipment, and energy and metering selections shall provide cost effective...

  11. 11 CFR 200.5 - Agency considerations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Agency considerations. 200.5 Section 200.5... Agency considerations. The Commission's decision on the petition for rulemaking may include, but will not be limited to, the following considerations— (a) The Commission's statutory authority; (b)...

  12. 7 CFR 1221.200 - Terms defined.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Terms defined. 1221.200 Section 1221.200 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SORGHUM PROMOTION, RESEARCH,...

  13. 7 CFR 1221.200 - Terms defined.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Terms defined. 1221.200 Section 1221.200 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SORGHUM PROMOTION, RESEARCH,...

  14. 7 CFR 1221.200 - Terms defined.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Terms defined. 1221.200 Section 1221.200 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SORGHUM PROMOTION, RESEARCH,...

  15. 7 CFR 1221.200 - Terms defined.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Terms defined. 1221.200 Section 1221.200 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SORGHUM PROMOTION, RESEARCH,...

  16. 49 CFR 172.200 - Applicability.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false Applicability. 172.200 Section 172.200 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS HAZARDOUS MATERIALS TABLE,...

  17. 49 CFR 172.200 - Applicability.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Applicability. 172.200 Section 172.200 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS HAZARDOUS MATERIALS TABLE,...

  18. 49 CFR 172.200 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Applicability. 172.200 Section 172.200 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS HAZARDOUS MATERIALS TABLE,...

  19. 49 CFR 172.200 - Applicability.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Applicability. 172.200 Section 172.200 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS HAZARDOUS MATERIALS TABLE,...

  20. 24 CFR 115.200 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Purpose. 115.200 Section 115.200 Housing and Urban Development Regulations Relating to Housing and Urban Development OFFICE OF ASSISTANT SECRETARY FOR EQUAL OPPORTUNITY, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT FAIR HOUSING CERTIFICATION...

  1. 17 CFR 200.410 - Miscellaneous.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Miscellaneous. 200.410 Section 200.410 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT... a sign language interpreter, should contact the Commission's Selective Placement Coordinator,...

  2. 21 CFR 1311.200 - Pharmacy responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 9 2014-04-01 2014-04-01 false Pharmacy responsibilities. 1311.200 Section 1311... ORDERS AND PRESCRIPTIONS Electronic Prescriptions § 1311.200 Pharmacy responsibilities. (a) Before initially using a pharmacy application to process controlled substance prescriptions, the pharmacy...

  3. 21 CFR 1311.200 - Pharmacy responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 9 2013-04-01 2013-04-01 false Pharmacy responsibilities. 1311.200 Section 1311... ORDERS AND PRESCRIPTIONS Electronic Prescriptions § 1311.200 Pharmacy responsibilities. (a) Before initially using a pharmacy application to process controlled substance prescriptions, the pharmacy...

  4. 21 CFR 1311.200 - Pharmacy responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 9 2012-04-01 2012-04-01 false Pharmacy responsibilities. 1311.200 Section 1311... ORDERS AND PRESCRIPTIONS Electronic Prescriptions § 1311.200 Pharmacy responsibilities. (a) Before initially using a pharmacy application to process controlled substance prescriptions, the pharmacy...

  5. 15 CFR 200.101 - Measurement research.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Measurement research. 200.101 Section... INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE MEASUREMENT SERVICES POLICIES, SERVICES, PROCEDURES, AND FEES § 200.101 Measurement research. (a) The NIST staff continually reviews the advances...

  6. 14 CFR 1251.200 - Discrimination prohibited.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Discrimination prohibited. 1251.200 Section... OF HANDICAP Employment Practices § 1251.200 Discrimination prohibited. (a) General. (1) No qualified handicapped person shall, on the basis of handicap, be subjected to discrimination in employment under...

  7. 14 CFR 1251.200 - Discrimination prohibited.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Discrimination prohibited. 1251.200 Section... OF HANDICAP Employment Practices § 1251.200 Discrimination prohibited. (a) General. (1) No qualified handicapped person shall, on the basis of handicap, be subjected to discrimination in employment under...

  8. 42 CFR 421.200 - Carrier functions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Carrier functions. 421.200 Section 421.200 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... a channel of communication to and from CMS of information, instructions, and other material...

  9. 24 CFR 572.200 - Planning grants.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Planning grants. 572.200 Section...) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND URBAN....200 Planning grants. Any planning grants made by HUD under the HOPE 3 program will continue to...

  10. 42 CFR 456.200 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Scope. 456.200 Section 456.200 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS UTILIZATION CONTROL Utilization Control: Mental Hospitals Utilization Review (ur)...

  11. 2 CFR 176.200 - Procedure.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Procedure. 176.200 Section 176.200 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved AWARD TERMS FOR ASSISTANCE AGREEMENTS THAT INCLUDE FUNDS UNDER THE AMERICAN RECOVERY...

  12. 17 CFR 200.660 - Communications.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 2 2012-04-01 2012-04-01 false Communications. 200.660 Section 200.660 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION... Communications. (a) The agency shall take appropriate steps to ensure effective communication with...

  13. 17 CFR 200.660 - Communications.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 2 2013-04-01 2013-04-01 false Communications. 200.660 Section 200.660 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION... Communications. (a) The agency shall take appropriate steps to ensure effective communication with...

  14. 31 CFR 1022.200 - General.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false General. 1022.200 Section 1022.200 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY RULES FOR MONEY SERVICES BUSINESSES Programs §...

  15. 31 CFR 1022.200 - General.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false General. 1022.200 Section 1022.200 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY RULES FOR MONEY SERVICES BUSINESSES Programs §...

  16. 21 CFR 1311.200 - Pharmacy responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 9 2011-04-01 2011-04-01 false Pharmacy responsibilities. 1311.200 Section 1311... ORDERS AND PRESCRIPTIONS Electronic Prescriptions § 1311.200 Pharmacy responsibilities. (a) Before initially using a pharmacy application to process controlled substance prescriptions, the pharmacy...

  17. 21 CFR 1311.200 - Pharmacy responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Pharmacy responsibilities. 1311.200 Section 1311... ORDERS AND PRESCRIPTIONS (Eff. 6-1-10) Electronic Prescriptions § 1311.200 Pharmacy responsibilities. (a) Before initially using a pharmacy application to process controlled substance prescriptions, the...

  18. 13 CFR 500.200 - Eligible Borrower.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... the financial and business plans of the company; (2) The prospective earning power of that company... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Eligible Borrower. 500.200 Section 500.200 Business Credit and Assistance EMERGENCY OIL AND GAS GUARANTEED LOAN BOARD EMERGENCY OIL...

  19. 13 CFR 500.200 - Eligible Borrower.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... the financial and business plans of the company; (2) The prospective earning power of that company... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Eligible Borrower. 500.200 Section 500.200 Business Credit and Assistance EMERGENCY OIL AND GAS GUARANTEED LOAN BOARD EMERGENCY OIL...

  20. 33 CFR 155.200 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ....200 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION OIL OR HAZARDOUS MATERIAL POLLUTION PREVENTION REGULATIONS FOR VESSELS Vessel Equipment § 155.200... outside the Boundary Lines, as defined in 46 CFR part 7, in any ocean or the Gulf of Mexico; any...

  1. 33 CFR 155.200 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....200 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION OIL OR HAZARDOUS MATERIAL POLLUTION PREVENTION REGULATIONS FOR VESSELS Vessel Equipment § 155.200... outside the Boundary Lines, as defined in 46 CFR part 7, in any ocean or the Gulf of Mexico; any...

  2. 33 CFR 155.200 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ....200 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION OIL OR HAZARDOUS MATERIAL POLLUTION PREVENTION REGULATIONS FOR VESSELS Vessel Equipment § 155.200... outside the Boundary Lines, as defined in 46 CFR part 7, in any ocean or the Gulf of Mexico; any...

  3. 33 CFR 155.200 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ....200 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION OIL OR HAZARDOUS MATERIAL POLLUTION PREVENTION REGULATIONS FOR VESSELS Vessel Equipment § 155.200... outside the Boundary Lines, as defined in 46 CFR part 7, in any ocean or the Gulf of Mexico; any...

  4. 33 CFR 155.200 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ....200 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION OIL OR HAZARDOUS MATERIAL POLLUTION PREVENTION REGULATIONS FOR VESSELS Vessel Equipment § 155.200... outside the Boundary Lines, as defined in 46 CFR part 7, in any ocean or the Gulf of Mexico; any...

  5. 12 CFR 303.200 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... section 38 of the FDI Act (12 U.S.C. 1831o), which requires insured depository institutions that are not... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Scope. 303.200 Section 303.200 Banks and... nonmember banks and § 325.103(c) for insured branches of foreign banks. (b) Institutions...

  6. 44 CFR 206.200 - General.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false General. 206.200 Section 206.200 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE Public Assistance Project Administration §...

  7. 18 CFR 1317.200 - Application.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 2 2014-04-01 2014-04-01 false Application. 1317.200 Section 1317.200 Conservation of Power and Water Resources TENNESSEE VALLEY AUTHORITY NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE...

  8. 18 CFR 1317.200 - Application.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Application. 1317.200 Section 1317.200 Conservation of Power and Water Resources TENNESSEE VALLEY AUTHORITY NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE...

  9. 18 CFR 1317.200 - Application.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 2 2013-04-01 2012-04-01 true Application. 1317.200 Section 1317.200 Conservation of Power and Water Resources TENNESSEE VALLEY AUTHORITY NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE...

  10. 7 CFR 1450.200 - General.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false General. 1450.200 Section 1450.200 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS BIOMASS CROP ASSISTANCE PROGRAM (BCAP)...

  11. 7 CFR 1450.200 - General.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false General. 1450.200 Section 1450.200 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS BIOMASS CROP ASSISTANCE PROGRAM (BCAP)...

  12. 7 CFR 1450.200 - General.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false General. 1450.200 Section 1450.200 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS BIOMASS CROP ASSISTANCE PROGRAM (BCAP)...

  13. 7 CFR 1450.200 - General.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false General. 1450.200 Section 1450.200 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS BIOMASS CROP ASSISTANCE PROGRAM (BCAP)...

  14. 42 CFR 416.200 - Payment adjustment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Payment adjustment. 416.200 Section 416.200 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... CMS as belonging to a class of new technology IOLs must submit claims using billing codes specified...

  15. 42 CFR 416.200 - Payment adjustment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Payment adjustment. 416.200 Section 416.200 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... CMS as belonging to a class of new technology IOLs must submit claims using billing codes specified...

  16. 45 CFR 144.200 - Basis.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...-term care insurance policies, and shall specify the type and format of the data to be reported and the... 45 Public Welfare 1 2010-10-01 2010-10-01 false Basis. 144.200 Section 144.200 Public Welfare... Social Security Act, (Act) which requires the issuer of a long-term care insurance policy issued under...

  17. 24 CFR 200.61 - Title.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Title. 200.61 Section 200.61 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA...

  18. 24 CFR 200.61 - Title.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Title. 200.61 Section 200.61 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA...

  19. 24 CFR 200.61 - Title.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Title. 200.61 Section 200.61 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA...

  20. 24 CFR 103.200 - Investigations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Investigations. 103.200 Section 103... HOUSING-COMPLAINT PROCESSING Investigation Procedures § 103.200 Investigations. (a) Upon the filing of a complaint under § 103.40, the Assistant Secretary will initiate an investigation. The purposes of...

  1. 24 CFR 103.200 - Investigations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Investigations. 103.200 Section 103... HOUSING-COMPLAINT PROCESSING Investigation Procedures § 103.200 Investigations. (a) Upon the filing of a complaint under § 103.40, the Assistant Secretary will initiate an investigation. The purposes of...

  2. 24 CFR 103.200 - Investigations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Investigations. 103.200 Section 103... HOUSING-COMPLAINT PROCESSING Investigation Procedures § 103.200 Investigations. (a) Upon the filing of a complaint under § 103.40, the Assistant Secretary will initiate an investigation. The purposes of...

  3. 24 CFR 103.200 - Investigations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Investigations. 103.200 Section 103... HOUSING-COMPLAINT PROCESSING Investigation Procedures § 103.200 Investigations. (a) Upon the filing of a complaint under § 103.40, the Assistant Secretary will initiate an investigation. The purposes of...

  4. 24 CFR 103.200 - Investigations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Investigations. 103.200 Section 103... HOUSING-COMPLAINT PROCESSING Investigation Procedures § 103.200 Investigations. (a) Upon the filing of a complaint under § 103.40, the Assistant Secretary will initiate an investigation. The purposes of...

  5. 17 CFR 200.66 - Investigations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false Investigations. 200.66 Section... ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.66 Investigations. The power to investigate... those facts. A member should never suggest, vote for, or participate in an investigation aimed at...

  6. 17 CFR 200.66 - Investigations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Investigations. 200.66 Section... ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.66 Investigations. The power to investigate... those facts. A member should never suggest, vote for, or participate in an investigation aimed at...

  7. 17 CFR 200.66 - Investigations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 2 2012-04-01 2012-04-01 false Investigations. 200.66 Section... ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.66 Investigations. The power to investigate... those facts. A member should never suggest, vote for, or participate in an investigation aimed at...

  8. 17 CFR 200.506 - Derivative classification.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 2 2013-04-01 2013-04-01 false Derivative classification. 200.506 Section 200.506 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION... assigned the same level of classification as the source; if, however, the basic information appears to...

  9. 24 CFR 200.100 - Insurance endorsement.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Insurance endorsement. 200.100... Endorsement Generally Applicable to Multifamily and Health Care Facility Mortgage Insurance Programs; and Continuing Eligibility Requirements for Existing Projects Endorsement § 200.100 Insurance endorsement....

  10. 24 CFR 200.100 - Insurance endorsement.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Insurance endorsement. 200.100... Endorsement Generally Applicable to Multifamily and Health Care Facility Mortgage Insurance Programs; and Continuing Eligibility Requirements for Existing Projects Endorsement § 200.100 Insurance endorsement....

  11. 24 CFR 200.100 - Insurance endorsement.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Insurance endorsement. 200.100... Endorsement Generally Applicable to Multifamily and Health Care Facility Mortgage Insurance Programs; and Continuing Eligibility Requirements for Existing Projects Endorsement § 200.100 Insurance endorsement....

  12. 17 CFR 200.71 - Fiduciary relationships.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Fiduciary relationships. 200...; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.71 Fiduciary relationships. A... are involved in questions to be determined by him. Such relationships would include...

  13. 17 CFR 200.71 - Fiduciary relationships.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false Fiduciary relationships. 200...; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.71 Fiduciary relationships. A... are involved in questions to be determined by him. Such relationships would include...

  14. 17 CFR 200.55 - Statutory obligations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 2 2013-04-01 2013-04-01 false Statutory obligations. 200.55... AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.55 Statutory obligations. In administering the law, members of this Commission should vigorously enforce compliance with the law by...

  15. 13 CFR 130.200 - Eligible entities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... or university; (3) A college or school of business, engineering, commerce or agriculture; (4) A... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Eligible entities. 130.200 Section 130.200 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS...

  16. 17 CFR 300.200 - General.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false General. 300.200 Section 300.200 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) Schedule A to Part 285 RULES OF THE SECURITIES INVESTOR PROTECTION CORPORATION Accounts Introduced by Other...

  17. 17 CFR 300.200 - General.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false General. 300.200 Section 300.200 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) Schedule A to Part 285 RULES OF THE SECURITIES INVESTOR PROTECTION CORPORATION Accounts Introduced by Other...

  18. 17 CFR 300.200 - General.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false General. 300.200 Section 300.200 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) Schedule A to Part 285 RULES OF THE SECURITIES INVESTOR PROTECTION CORPORATION Accounts Introduced by Other...

  19. 17 CFR 300.200 - General.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false General. 300.200 Section 300.200 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) Schedule A to Part 285 RULES OF THE SECURITIES INVESTOR PROTECTION CORPORATION Accounts Introduced by Other...

  20. 17 CFR 300.200 - General.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false General. 300.200 Section 300.200 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) Schedule A to Part 285 RULES OF THE SECURITIES INVESTOR PROTECTION CORPORATION Accounts Introduced by Other...

  1. 42 CFR 93.200 - Administrative action.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Administrative action. 93.200 Section 93.200 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON...

  2. 14 CFR 1251.200 - Discrimination prohibited.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Discrimination prohibited. 1251.200 Section... OF HANDICAP Employment Practices § 1251.200 Discrimination prohibited. (a) General. (1) No qualified handicapped person shall, on the basis of handicap, be subjected to discrimination in employment under...

  3. 2 CFR 200.455 - Organization costs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Organization costs. 200.455 Section 200.455... Organization costs. Costs such as incorporation fees, brokers' fees, fees to promoters, organizers or...-Federal entity in connection with establishment or reorganization of an organization, are...

  4. 24 CFR 200.78 - Energy conservation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Energy conservation. 200.78 Section... Eligibility Requirements for Existing Projects Property Requirements § 200.78 Energy conservation. Construction, mechanical equipment, and energy and metering selections shall provide cost effective...

  5. 24 CFR 200.78 - Energy conservation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Energy conservation. 200.78 Section... Eligibility Requirements for Existing Projects Property Requirements § 200.78 Energy conservation. Construction, mechanical equipment, and energy and metering selections shall provide cost effective...

  6. 24 CFR 200.78 - Energy conservation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Energy conservation. 200.78 Section... Eligibility Requirements for Existing Projects Property Requirements § 200.78 Energy conservation. Construction, mechanical equipment, and energy and metering selections shall provide cost effective...

  7. 13 CFR 400.200 - Eligible Borrower.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 400.200 Business Credit and Assistance EMERGENCY STEEL GUARANTEE LOAN BOARD EMERGENCY STEEL GUARANTEE LOAN PROGRAM Steel Guarantee Loans § 400.200 Eligible Borrower. (a) An eligible Borrower must be a Qualified Steel Company that can demonstrate: (1) Credit is not otherwise available to it under...

  8. 13 CFR 400.200 - Eligible Borrower.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 400.200 Business Credit and Assistance EMERGENCY STEEL GUARANTEE LOAN BOARD EMERGENCY STEEL GUARANTEE LOAN PROGRAM Steel Guarantee Loans § 400.200 Eligible Borrower. (a) An eligible Borrower must be a Qualified Steel Company that can demonstrate: (1) Credit is not otherwise available to it under...

  9. 13 CFR 400.200 - Eligible Borrower.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 400.200 Business Credit and Assistance EMERGENCY STEEL GUARANTEE LOAN BOARD EMERGENCY STEEL GUARANTEE LOAN PROGRAM Steel Guarantee Loans § 400.200 Eligible Borrower. (a) An eligible Borrower must be a Qualified Steel Company that can demonstrate: (1) Credit is not otherwise available to it under...

  10. 13 CFR 400.200 - Eligible Borrower.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 400.200 Business Credit and Assistance EMERGENCY STEEL GUARANTEE LOAN BOARD EMERGENCY STEEL GUARANTEE LOAN PROGRAM Steel Guarantee Loans § 400.200 Eligible Borrower. (a) An eligible Borrower must be a Qualified Steel Company that can demonstrate: (1) Credit is not otherwise available to it under...

  11. 13 CFR 400.200 - Eligible Borrower.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 400.200 Business Credit and Assistance EMERGENCY STEEL GUARANTEE LOAN BOARD EMERGENCY STEEL GUARANTEE LOAN PROGRAM Steel Guarantee Loans § 400.200 Eligible Borrower. (a) An eligible Borrower must be a Qualified Steel Company that can demonstrate: (1) Credit is not otherwise available to it under...

  12. 14 CFR § 1214.200 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Scope. § 1214.200 Section § 1214.200 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Reimbursement for Shuttle... Shuttle services which are provided by NASA to users (as defined in § 1214.201) under launch...

  13. 14 CFR 1214.200 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Scope. 1214.200 Section 1214.200 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Reimbursement for Shuttle... Shuttle services which are provided by NASA to users (as defined in § 1214.201) under launch...

  14. 14 CFR 1214.200 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Scope. 1214.200 Section 1214.200 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Reimbursement for Shuttle... Shuttle services which are provided by NASA to users (as defined in § 1214.201) under launch...

  15. 14 CFR 1214.200 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Scope. 1214.200 Section 1214.200 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Reimbursement for Shuttle... Shuttle services which are provided by NASA to users (as defined in § 1214.201) under launch...

  16. 14 CFR 1214.200 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Scope. 1214.200 Section 1214.200 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Reimbursement for Shuttle... Shuttle services which are provided by NASA to users (as defined in § 1214.201) under launch...

  17. 24 CFR 200.52 - Construction contract.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Construction contract. 200.52 Section 200.52 Housing and Urban Development Regulations Relating to Housing and Urban Development... Construction contract. The form of contract between the mortgagor and builder shall be as prescribed by...

  18. 24 CFR 200.24 - Existing projects.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Existing projects. 200.24 Section... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and Endorsement... Eligibility Requirements for Existing Projects Miscellaneous Project Mortgage Insurance § 200.24...

  19. 7 CFR 1250.200 - Referenda.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Referenda. 1250.200 Section 1250.200 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE EGG RESEARCH AND...

  20. 34 CFR 200.71 - LEA eligibility.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... least five percent of the LEA's total population ages 5 to 17 years, inclusive. (d) Education finance... 34 Education 1 2010-07-01 2010-07-01 false LEA eligibility. 200.71 Section 200.71 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY...

  1. 2 CFR 200.473 - Transportation costs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Transportation costs. 200.473 Section 200... MANAGEMENT AND BUDGET GUIDANCE Reserved UNIFORM ADMINISTRATIVE REQUIREMENTS, COST PRINCIPLES, AND AUDIT REQUIREMENTS FOR FEDERAL AWARDS Cost Principles General Provisions for Selected Items of Cost §...

  2. 49 CFR 179.200-7 - Materials.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... with other approved materials: Specifications Minimum tensile strength (p.s.i.) welded condition 1... 49 Transportation 2 2010-10-01 2010-10-01 false Materials. 179.200-7 Section 179.200-7 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS...

  3. 15 CFR 280.200 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Scope. 280.200 Section 280.200 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE ACCREDITATION AND ASSESSMENT PROGRAMS FASTENER...

  4. 24 CFR 200.24 - Existing projects.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Existing projects. 200.24 Section... Eligibility Requirements for Existing Projects Miscellaneous Project Mortgage Insurance § 200.24 Existing projects. A mortgage financing the purchase or refinance of an existing rental housing project...

  5. 24 CFR 200.24 - Existing projects.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Existing projects. 200.24 Section... Eligibility Requirements for Existing Projects Miscellaneous Project Mortgage Insurance § 200.24 Existing projects. A mortgage financing the purchase or refinance of an existing rental housing project...

  6. 24 CFR 266.200 - Eligible projects.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Eligible projects. 266.200 Section... FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Program Requirements § 266.200 Eligible projects. (a) Minimum project size. Projects insured under this part must consist...

  7. 24 CFR 266.200 - Eligible projects.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Eligible projects. 266.200 Section... FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Program Requirements § 266.200 Eligible projects. (a) Minimum project size. Projects insured under this part must consist...

  8. 24 CFR 200.24 - Existing projects.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Existing projects. 200.24 Section... Eligibility Requirements for Existing Projects Miscellaneous Project Mortgage Insurance § 200.24 Existing projects. A mortgage financing the purchase or refinance of an existing rental housing project...

  9. 24 CFR 266.200 - Eligible projects.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Eligible projects. 266.200 Section... FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Program Requirements § 266.200 Eligible projects. (a) Minimum project size. Projects insured under this part must consist...

  10. 24 CFR 200.24 - Existing projects.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Existing projects. 200.24 Section... Eligibility Requirements for Existing Projects Miscellaneous Project Mortgage Insurance § 200.24 Existing projects. A mortgage financing the purchase or refinance of an existing rental housing project...

  11. 24 CFR 266.200 - Eligible projects.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Eligible projects. 266.200 Section... FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Program Requirements § 266.200 Eligible projects. (a) Minimum project size. Projects insured under this part must consist...

  12. 17 CFR 200.311 - Penalties.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Penalties. 200.311 Section 200.311 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Regulations Pertaining to the Privacy of Individuals and Systems...

  13. 17 CFR 200.310 - Fees.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Fees. 200.310 Section 200.310 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Regulations Pertaining to the Privacy of Individuals and Systems of...

  14. 17 CFR 200.312 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Specific exemptions. 200.312 Section 200.312 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Regulations Pertaining to the Privacy of Individuals...

  15. 17 CFR 200.302 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Definitions. 200.302 Section 200.302 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Regulations Pertaining to the Privacy of Individuals...

  16. 17 CFR 200.309 - General provisions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false General provisions. 200.309 Section 200.309 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Regulations Pertaining to the Privacy of Individuals...

  17. 17 CFR 200.660 - Communications.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Communications. 200.660 Section 200.660 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION... Communications. (a) The agency shall take appropriate steps to ensure effective communication with...

  18. 34 CFR 200.16 - Starting points.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Starting points. 200.16 Section 200.16 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION, DEPARTMENT OF EDUCATION TITLE I-IMPROVING THE ACADEMIC ACHIEVEMENT OF THE DISADVANTAGED Improving Basic Programs Operated by Local Educational...

  19. 40 CFR 300.200 - General.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 29 2013-07-01 2013-07-01 false General. 300.200 Section 300.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND... Community Right-to-Know Act of 1986” but referred to herein as “Title III.” Regulations implementing...

  20. 21 CFR 1271.200 - Equipment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Equipment. 1271.200 Section 1271.200 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) REGULATIONS UNDER CERTAIN OTHER ACTS ADMINISTERED BY THE FOOD AND DRUG ADMINISTRATION HUMAN CELLS, TISSUES,...

  1. 17 CFR 200.70 - Business promotions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 3 2014-04-01 2014-04-01 false Business promotions. 200.70... AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.70 Business promotions. A member must not engage in any other business, employment or vocation while in office, nor may he ever use...

  2. 17 CFR 200.70 - Business promotions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 2 2013-04-01 2013-04-01 false Business promotions. 200.70... AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.70 Business promotions. A member must not engage in any other business, employment or vocation while in office, nor may he ever use...

  3. 17 CFR 200.70 - Business promotions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false Business promotions. 200.70... AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.70 Business promotions. A member must not engage in any other business, employment or vocation while in office, nor may he ever use...

  4. 17 CFR 200.70 - Business promotions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 2 2012-04-01 2012-04-01 false Business promotions. 200.70... AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.70 Business promotions. A member must not engage in any other business, employment or vocation while in office, nor may he ever use...

  5. 24 CFR 200.25 - Supplemental loans.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Supplemental loans. 200.25 Section 200.25 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... loans. A loan, advance of credit or purchase of an obligation representing a loan or advance of...

  6. 24 CFR 200.25 - Supplemental loans.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Supplemental loans. 200.25 Section 200.25 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... loans. A loan, advance of credit or purchase of an obligation representing a loan or advance of...

  7. 24 CFR 200.25 - Supplemental loans.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Supplemental loans. 200.25 Section 200.25 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... loans. A loan, advance of credit or purchase of an obligation representing a loan or advance of...

  8. 2 CFR 200.423 - Alcoholic beverages.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Alcoholic beverages. 200.423 Section 200.423 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF... Alcoholic beverages. Costs of alcoholic beverages are unallowable....

  9. 24 CFR 200.100 - Insurance endorsement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Insurance endorsement. 200.100... Endorsement Generally Applicable to Multifamily and Health Care Facility Mortgage Insurance Programs; and Continuing Eligibility Requirements for Existing Projects Endorsement § 200.100 Insurance endorsement....

  10. 24 CFR 200.100 - Insurance endorsement.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Insurance endorsement. 200.100... Endorsement Generally Applicable to Multifamily and Health Care Facility Mortgage Insurance Programs; and Continuing Eligibility Requirements for Existing Projects Endorsement § 200.100 Insurance endorsement....

  11. 49 CFR 179.200-3 - Type.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Type. 179.200-3 Section 179.200-3 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for...

  12. 49 CFR 179.200-4 - Insulation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Insulation. 179.200-4 Section 179.200-4 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for...

  13. 49 CFR 179.200-3 - Type.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Type. 179.200-3 Section 179.200-3 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for...

  14. 49 CFR 179.200-10 - Welding.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Welding. 179.200-10 Section 179.200-10 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for...

  15. 49 CFR 179.200-4 - Insulation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Insulation. 179.200-4 Section 179.200-4 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for...

  16. 49 CFR 179.200-10 - Welding.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Welding. 179.200-10 Section 179.200-10 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for...

  17. 49 CFR 179.200-10 - Welding.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Welding. 179.200-10 Section 179.200-10 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for...

  18. 49 CFR 179.200-24 - Stamping.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Stamping. 179.200-24 Section 179.200-24 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for...

  19. 49 CFR 179.200-24 - Stamping.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Stamping. 179.200-24 Section 179.200-24 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for...

  20. 49 CFR 179.200-4 - Insulation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Insulation. 179.200-4 Section 179.200-4 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for...

  1. 49 CFR 179.200-3 - Type.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Type. 179.200-3 Section 179.200-3 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for...

  2. 49 CFR 179.200-4 - Insulation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Insulation. 179.200-4 Section 179.200-4 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for...

  3. 49 CFR 179.200-3 - Type.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Type. 179.200-3 Section 179.200-3 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS SPECIFICATIONS FOR TANK CARS Specifications...

  4. 49 CFR 179.200-3 - Type.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Type. 179.200-3 Section 179.200-3 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for...

  5. 17 CFR 200.660 - Communications.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false Communications. 200.660 Section 200.660 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION... Communications. (a) The agency shall take appropriate steps to ensure effective communication with...

  6. 34 CFR 200.52 - LEA improvement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 1 2012-07-01 2012-07-01 false LEA improvement. 200.52 Section 200.52 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION, DEPARTMENT OF EDUCATION TITLE I-IMPROVING THE ACADEMIC ACHIEVEMENT OF THE DISADVANTAGED Improving...

  7. 34 CFR 200.42 - Corrective action.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 1 2012-07-01 2012-07-01 false Corrective action. 200.42 Section 200.42 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION, DEPARTMENT OF EDUCATION TITLE I-IMPROVING THE ACADEMIC ACHIEVEMENT OF THE DISADVANTAGED Improving...

  8. 34 CFR 200.81 - Program definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 1 2012-07-01 2012-07-01 false Program definitions. 200.81 Section 200.81 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION, DEPARTMENT OF EDUCATION TITLE I-IMPROVING THE ACADEMIC ACHIEVEMENT OF THE DISADVANTAGED Migrant...

  9. Results and Status of EXO-200

    NASA Astrophysics Data System (ADS)

    Daniels, Tim; Kaufman, Lisa; EXO-200 Collaboration

    2016-09-01

    EXO-200 has provided one of the most sensitive searches for neutrinoless double-beta decay utilizing 175 kg of enriched liquid xenon in an ultra-low background time projection chamber. This detector has demonstrated excellent energy resolution and background rejection capabilities. Using the first two years of data, EXO-200 has set a limit of 1 . 1 ×1025 y at 90% C.L. on the neutrinoless double-beta decay half-life of Xe136. The experiment has experienced a brief hiatus in data taking during a temporary shutdown of its host facility: the Waste Isolation Pilot Plant. EXO-200 has resumed data taking in earnest with upgraded detector electronics. Results from the analysis of EXO-200 data and an update on the current status of EXO-200 will be presented.

  10. Result from, and status of, EXO-200

    NASA Astrophysics Data System (ADS)

    Daniels, Tim; EXO-200 Collaboration

    2017-01-01

    EXO-200 has provided one of the most sensitive searches for neutrinoless double-beta decay utilizing 175 kg of enriched liquid xenon in an ultra-low background time projection chamber. This detector has demonstrated excellent energy resolution and background rejection capabilities. Using the first two years of data, EXO-200 has set a limit of 1 . 1 ×1025 y at 90 double-beta decay half-life of 136Xe. The experiment has experienced a brief hiatus in data taking during a temporary shutdown of its host facility: the Waste Isolation Pilot Plant. EXO-200 has resumed data taking in earnest with upgraded detector electronics. Results from the analysis of EXO-200 data and an update on the current status of EXO-200 will be presented.

  11. 17 CFR 200.313 - Inspector General exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., 200.306, 200.307, 200.308, 200.309 and 200.310, insofar as the system contains information pertaining... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Inspector General exemptions. 200.313 Section 200.313 Commodity and Securities Exchanges SECURITIES AND EXCHANGE...

  12. Colorectal cancer cell-derived microRNA200 modulates the resistance of adjacent blood endothelial barriers in vitro.

    PubMed

    Holzner, Silvio; Senfter, Daniel; Stadler, Serena; Staribacher, Anna; Nguyen, Chi Huu; Gaggl, Anna; Geleff, Silvana; Huttary, Nicole; Krieger, Sigurd; Jäger, Walter; Dolznig, Helmut; Mader, Robert M; Krupitza, Georg

    2016-11-01

    Since cancer cells, when grown as spheroids, display drug sensitivity and radiation resistance patterns such as seen in vivo we recently established a three‑dimensional (3D) in vitro model recapitulating colorectal cancer (CRC)-triggered lymphatic endothelial cell (LEC)‑barrier breaching to study mechanisms of intra‑/extravasation. CRC metastasizes not only through lymphatics but also through blood vessels and here we extend the 3D model to the interaction of blood endothelial cells (BECs) with naïve and 5‑fluorouracil (5‑FU)‑resistant CRC CCL227 cells. The 3D model enabled quantifying effects of tumour‑derived microRNA200 (miR200) miR200a, miR200b, miR200c, miR141 and miR429 regarding the induction of so-called 'circular chemorepellent‑induced defects' (CCIDs) within the BEC‑barrier, which resemble gates for tumour transmigration. For this, miR200 precursors were individually transfected and furthermore, the modulation of ZEB family expression was analysed by western blotting. miR200c, miR141 and miR429, which are contained in exosomes from naïve CCL227 cells, downregulated the expression of ZEB2, SNAI and TWIST in BECs. The exosomes of 5‑FU‑resistant CCL227‑RH cells, which are devoid of miR200, accelerated CCID formation in BEC monolayers as compared to exosomes from naïve CCL227 cells. This confirmed the reported role of ZEB2 and SNAI in CRC metastasis and highlighted the active contribution of the stroma in the metastatic process. CCL227 spheroids affected the integrity of BEC and LEC barriers alike, which was in agreement with the observation that CRC metastasizes via blood stream (into the liver) as well as via lymphatics (into lymph nodes and lungs). This further validated the CRC/LEC and CRC/BEC in vitro model to study mechanisms of CRC spreading through vascular systems. Treatment of CCL227‑RH cells with the HDAC inhibitors mocetinostat and sulforaphane reduced CCID formation to the level triggered by naïve CCL227

  13. 7 CFR 930.200 - Assessment rate.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... MICHIGAN, NEW YORK, PENNSYLVANIA, OREGON, UTAH, WASHINGTON, AND WISCONSIN Assessment Rates § 930.200... products. Included in this rate is $0.005 per pound of cherries to cover the cost of the research...

  14. 46 CFR 119.200 - General.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS MACHINERY INSTALLATION Propulsion Machinery § 119.200 General. (a) Propulsion machinery must be suitable in type and design for propulsion requirements of...

  15. 46 CFR 121.200 - General.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Cooking and Heating § 121.200 General. Cooking and heating equipment must be suitable for marine use... Heating Systems,” or with National Fire Protection Association (NFPA) 302, “Pleasure and Commercial...

  16. 46 CFR 121.200 - General.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Cooking and Heating § 121.200 General. Cooking and heating equipment must be suitable for marine use... Heating Systems,” or with National Fire Protection Association (NFPA) 302, “Pleasure and Commercial...

  17. 46 CFR 121.200 - General.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Cooking and Heating § 121.200 General. Cooking and heating equipment must be suitable for marine use... Heating Systems,” or with National Fire Protection Association (NFPA) 302, “Pleasure and Commercial...

  18. 46 CFR 121.200 - General.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Cooking and Heating § 121.200 General. Cooking and heating equipment must be suitable for marine use... Heating Systems,” or with National Fire Protection Association (NFPA) 302, “Pleasure and Commercial...

  19. 24 CFR 200.605 - Authority.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... GENERAL INTRODUCTION TO FHA PROGRAMS Affirmative Fair Housing Marketing Regulations § 200.605 Authority.... 3535(d), and implement the functions, powers, and duties imposed on the Secretary by Executive...

  20. 24 CFR 200.73 - Property development.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and... Continuing Eligibility Requirements for Existing Projects Property Requirements § 200.73 Property development... Commissioner. (b) A project may include such commercial and community facilities as the Commissioner...

  1. 24 CFR 200.17 - Mortgage coverage.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and Endorsement... Eligibility Requirements for Existing Projects Eligible Mortgage § 200.17 Mortgage coverage. The mortgage shall cover the entire property included in the project....

  2. 24 CFR 200.15 - Maximum mortgage.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and Endorsement... Eligibility Requirements for Existing Projects Eligible Mortgage § 200.15 Maximum mortgage. Mortgages must not... the Commissioner determines it necessary on a project-by-project basis....

  3. 24 CFR 200.73 - Property development.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and... Continuing Eligibility Requirements for Existing Projects Property Requirements § 200.73 Property development... Commissioner. (b) A project may include such commercial and community facilities as the Commissioner...

  4. 24 CFR 200.88 - Late charge.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and Endorsement Generally... Requirements for Existing Projects Mortgage Provisions § 200.88 Late charge. The mortgage may provide for...

  5. 24 CFR 200.17 - Mortgage coverage.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and Endorsement... Eligibility Requirements for Existing Projects Eligible Mortgage § 200.17 Mortgage coverage. The mortgage shall cover the entire property included in the project....

  6. 24 CFR 200.15 - Maximum mortgage.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and Endorsement... Eligibility Requirements for Existing Projects Eligible Mortgage § 200.15 Maximum mortgage. Mortgages must not... the Commissioner determines it necessary on a project-by-project basis....

  7. 24 CFR 200.88 - Late charge.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and Endorsement Generally... Requirements for Existing Projects Mortgage Provisions § 200.88 Late charge. The mortgage may provide for...

  8. 21 CFR 131.200 - Yogurt.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... CONSUMPTION MILK AND CREAM Requirements for Specific Standardized Milk and Cream § 131.200 Yogurt. (a..., within limits of current good manufacturing practice. (c) Optional dairy ingredients. Cream,...

  9. 40 CFR 246.200-1 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SEPARATION FOR MATERIALS RECOVERY GUIDELINES Requirements and Recommended Procedures § 246.200-1 Requirements. High-grade paper generated by office facilities of over 100 office workers shall be separated at...

  10. 42 CFR 495.200 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... (as described in section 1861(r) of the Act), including a doctor of medicine or osteopathy who is..., the added and revised text is set forth as follows: § 495.200 Definitions. MA payment adjustment...

  11. 28 CFR 16.200 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Observation of Parole Commission Meetings § 16.200 Definitions. As used in this part: (a) The term Commission means the U.S. Parole Commision and any subdivision thereof authorized to act on its behalf. (b)...

  12. 28 CFR 16.200 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Observation of Parole Commission Meetings § 16.200 Definitions. As used in this part: (a) The term Commission means the U.S. Parole Commission and any subdivision thereof authorized to act on its behalf. (b)...

  13. 28 CFR 16.200 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Observation of Parole Commission Meetings § 16.200 Definitions. As used in this part: (a) The term Commission means the U.S. Parole Commision and any subdivision thereof authorized to act on its behalf. (b)...

  14. 28 CFR 16.200 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Observation of Parole Commission Meetings § 16.200 Definitions. As used in this part: (a) The term Commission means the U.S. Parole Commission and any subdivision thereof authorized to act on its behalf. (b)...

  15. 28 CFR 16.200 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Observation of Parole Commission Meetings § 16.200 Definitions. As used in this part: (a) The term Commission means the U.S. Parole Commision and any subdivision thereof authorized to act on its behalf. (b)...

  16. 21 CFR 1271.200 - Equipment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... UNDER CERTAIN OTHER ACTS ADMINISTERED BY THE FOOD AND DRUG ADMINISTRATION HUMAN CELLS, TISSUES, AND CELLULAR AND TISSUE-BASED PRODUCTS Current Good Tissue Practice § 1271.200 Equipment. (a) General....

  17. 46 CFR 182.200 - General.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... INSTALLATION Propulsion Machinery § 182.200 General. (a) Propulsion machinery must be suitable in type and design for propulsion requirements of the hull in which it is installed and capable of operating...

  18. 46 CFR 182.200 - General.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... INSTALLATION Propulsion Machinery § 182.200 General. (a) Propulsion machinery must be suitable in type and design for propulsion requirements of the hull in which it is installed and capable of operating...

  19. 46 CFR 119.200 - General.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS MACHINERY INSTALLATION Propulsion Machinery § 119.200 General. (a) Propulsion machinery must be suitable in type and design for propulsion requirements of...

  20. 46 CFR 182.200 - General.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... INSTALLATION Propulsion Machinery § 182.200 General. (a) Propulsion machinery must be suitable in type and design for propulsion requirements of the hull in which it is installed and capable of operating...

  1. 46 CFR 119.200 - General.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS MACHINERY INSTALLATION Propulsion Machinery § 119.200 General. (a) Propulsion machinery must be suitable in type and design for propulsion requirements of...

  2. 46 CFR 119.200 - General.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS MACHINERY INSTALLATION Propulsion Machinery § 119.200 General. (a) Propulsion machinery must be suitable in type and design for propulsion requirements of...

  3. 46 CFR 182.200 - General.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... INSTALLATION Propulsion Machinery § 182.200 General. (a) Propulsion machinery must be suitable in type and design for propulsion requirements of the hull in which it is installed and capable of operating...

  4. 46 CFR 119.200 - General.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS MACHINERY INSTALLATION Propulsion Machinery § 119.200 General. (a) Propulsion machinery must be suitable in type and design for propulsion requirements of...

  5. 46 CFR 182.200 - General.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... INSTALLATION Propulsion Machinery § 182.200 General. (a) Propulsion machinery must be suitable in type and design for propulsion requirements of the hull in which it is installed and capable of operating...

  6. 33 CFR 146.200 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... CONTINENTAL SHELF ACTIVITIES OPERATIONS Mobile Offshore Drilling Units § 146.200 Definitions. For the purpose... given by the Bureau of Ocean Energy Management, Regulation and Enforcement (BOE) to define the OCS...

  7. 33 CFR 146.200 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... CONTINENTAL SHELF ACTIVITIES OPERATIONS Mobile Offshore Drilling Units § 146.200 Definitions. For the purpose... given by the Bureau of Ocean Energy Management, Regulation and Enforcement (BOE) to define the OCS...

  8. 33 CFR 146.200 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... CONTINENTAL SHELF ACTIVITIES OPERATIONS Mobile Offshore Drilling Units § 146.200 Definitions. For the purpose... given by the Bureau of Ocean Energy Management, (BOEM) to define the OCS areas used to...

  9. 33 CFR 146.200 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... CONTINENTAL SHELF ACTIVITIES OPERATIONS Mobile Offshore Drilling Units § 146.200 Definitions. For the purpose... given by the Bureau of Ocean Energy Management, Regulation and Enforcement (BOE) to define the OCS...

  10. 24 CFR 200.615 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Affirmative Fair Housing Marketing Regulations § 200.615 Applicability. The affirmative fair housing marketing requirements, as set forth in paragraphs (a) through...

  11. 24 CFR 200.610 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... GENERAL INTRODUCTION TO FHA PROGRAMS Affirmative Fair Housing Marketing Regulations § 200.610 Policy. It... programs shall pursue affirmative fair housing marketing policies in soliciting buyers and tenants,...

  12. Prediction of 200-m sprint kayaking performance.

    PubMed

    van Someren, Ken A; Palmer, Garry S

    2003-08-01

    The aim of this study was to determine the anthropometric and physiological profile of 200-m sprint kayakers and to examine relationships with 200-m race performance. Twenty-six male kayakers who were categorised in two ability groups, international (Int) and national (Nat) level, underwent a battery of anthropometric and physiological tests and a 200-m race. Race time was significantly lower in Int than Nat (39.9 +/- 0.8 s and 42.6 +/- 0.9 s, respectively). Int demonstrated significantly greater measures of mesomorphy, biepycondylar humeral breadth, circumferences of the upper arm, forearm and chest, peak power and total work in a modified Wingate test, total work in a 2-min ergometry test, peak isokinetic power, and peak isometric force. Significant relationships were found between 200-m time and a number of anthropometric variables and anaerobic and dynamometric parameters. Stepwise multiple regression revealed that total work in the modified Wingate alone predicted 200-m race time (R2 = 0.53, SEE = 1.11 s) for all 26 subjects, while biepycondylar humeral breadth alone predicted race time (R2 = 0.54, SEE = 0.52 s) in Int. These results demonstrate that superior upper body dimensions and anaerobic capacities distinguish international-level kayakers from national-level athletes and may be used to predict 200-m performance.

  13. 75 FR 70102 - Airworthiness Directives; The Boeing Company Model 777-200, -200LR, -300, and -300ER Series...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-17

    ... Model 777-200, - 200LR, -300, and -300ER Series Airplanes AGENCY: Federal Aviation Administration (FAA... 777-200, -200LR, -300, and -300ER series airplanes. This AD requires removing and repairing the... airworthiness directive (AD) that would apply to certain Model 777-200, -200LR, -300, and -300ER...

  14. 75 FR 17889 - Airworthiness Directives; The Boeing Company Model 777-200, -200LR, -300, and -300ER Series...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-08

    ... Model 777-200, - 200LR, -300, and -300ER Series Airplanes AGENCY: Federal Aviation Administration (FAA... directive (AD) for certain Model 777-200, -200LR, -300, and -300ER series airplanes. This proposed AD would...) This AD applies to The Boeing Company Model 777-200, -200LR, -300, and -300ER series...

  15. Niclosamide inhibits colon cancer progression through downregulation of the Notch pathway and upregulation of the tumor suppressor miR-200 family

    PubMed Central

    Suliman, Mohammed A.; Zhang, Zhenxing; Na, Heya; Ribeiro, Ailton L.L.; Zhang, Yu; Niang, Bachir; Hamid, Abdu Salim; Zhang, Hua; Xu, Lijie; Zuo, Yunfei

    2016-01-01

    Colorectal cancer (CRC) is among the most frequent causes of cancer-related deaths worldwide. Thus, there is a need for the development of new therapeutic approaches for the treatment of CRC. Accumulating evidence has revealed that niclosamide, an anthelminthic drug, exerts antitumor activity in several types of cancer, including colon cancer. However, the underlying molecular mechanisms responsible for the effects of this drug remain elusive. Previous studies have shown that the aberrant Notch signaling pathway contributes to the carcinogenesis of colon cancer. Herein, we examined the effects of niclosamide on the growth, migration and apoptosis of colon cancer cells, and the role of the Notch signaling pathway. By performing MTT, wound-healing and Transwell migration assays, we observed that niclosamide suppressed the growth and migration of colon cancer cells, and flow cytometry demonstrated that cell apoptosis was induced. This was associated with the decreased protein expression of Notch1, Notch2, Notch3 and Hey1, and the increased expression of the tumor suppressor microRNA (miR or miRNA)-200 family members (miR-200a, miR-200b, miR-200c, miR-141 and miR-429) that are typically downregulated in colon cancer. Collectively, these findings demonstrate that niclosamide potentially inhibits the progression of colon cancer by downregulating Notch signaling and by upregulating the miR-200 family members. PMID:27460529

  16. Proteasome activator 200: the heat is on...

    PubMed

    Savulescu, Anca F; Glickman, Michael H

    2011-05-01

    Proteasomes play a key regulatory role in all eukaryotic cells by removing proteins in a timely manner. There are two predominant forms: The 20S core particle (CP) can hydrolyze peptides and certain unstructured proteins, and the 26S holoenzyme is able to proteolyse most proteins conjugated to ubiquitin. The 26S complex consists of a CP barrel with a 19S regulatory particle (RP; a.k.a PA700) attached to its outer surface. Several studies purified another proteasome activator with a MW of 200 kDa (PA200) that attaches to the same outer ring of the CP. A role for PA200 has been demonstrated in spermatogenesis, in response to DNA repair and in maintenance of mitochondrial inheritance. Enhanced levels of PA200-CP complexes are observed under conditions in which either activated or disrupted CP prevail, suggesting it participates in regulating overall proteolytic activity. PA200, or its yeast ortholog Blm10, may also incorporate into 26S proteasomes yielding PA200-CP-RP hybrids. A three-dimensional molecular structure determined by x-ray crystallography of Blm10-CP provides a model for activation. The carboxy terminus of Blm10 inserts into a dedicated pocket in the outer ring of the CP surface, whereas multiple HEAT-like repeats fold into an asymmetric solenoid wrapping around the central pore to stabilize a partially open conformation. The resulting hollow domelike structure caps the entire CP surface. This asymmetric structure may provide insight as to how the 19S RP, with two HEAT repeatlike subunits (Rpn1, Rpn2) alongside six ATPases (Rpt1-6), attaches to the same surface of the CP ring, and likewise, induces pore opening.

  17. 200 West Area Dust Mitigation Strategies

    SciTech Connect

    Sackschewsky, Michael R.; Becker, James M.

    2001-04-12

    Various strategies were developed for the purpose of mitigating respirable dust experienced at facilities in the southwest corner of the 200 West Area. These strategies focused on treatment of that portion of the dust source located within the 200 West Expansion Area. Strategies included direct shielding of the facilities via establishment of a poplar windbreak and installation of an artificial windscreen; soil stabilization via seeding of herbaceous plants, soil fixatives, straw crimping, straw blankets, gravel mulches, drift fences, baled straw, and living fences; and various irrigation systems that would function both to water seeded herbs and to suppress dust.

  18. Supercapacitor operating at 200 degrees celsius.

    PubMed

    Borges, Raquel S; Reddy, Arava Leela Mohana; Rodrigues, Marco-Tulio F; Gullapalli, Hemtej; Balakrishnan, Kaushik; Silva, Glaura G; Ajayan, Pulickel M

    2013-01-01

    The operating temperatures of current electrochemical energy storage devices are limited due to electrolyte degradation and separator instability at higher temperatures. Here we demonstrate that a tailored mixture of materials can facilitate operation of supercapacitors at record temperatures, as high as 200°C. Composite electrolyte/separator structures made from naturally occurring clay and room temperature ionic liquids, with graphitic carbon electrodes, show stable supercapacitor performance at 200°C with good cyclic stability. Free standing films of such high temperature composite electrolyte systems can become versatile functional membranes in several high temperature energy conversion and storage applications.

  19. 200 North Aggregate Area source AAMS report

    SciTech Connect

    Not Available

    1993-06-01

    This report presents the results of an aggregate area management study (AAMS) for the 200 North Aggregate Area in the 200 Areas of the US Department of Energy (DOE) Hanford Site in Washington State. This scoping level study provides the basis for initiating Remedial Investigation/Feasibility Study (RI/FS) activities under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) or Resource Conservation and Recovery Act (RCRA) Facility Investigations (RFI) and Corrective Measures Studies (CMS) under RCRA. This report also integrates select RCRA treatment, storage, or disposal (TSD) closure activities with CERCLA and RCRA past practice investigations.

  20. Downregulated microRNA-200a promotes EMT and tumor growth through the wnt/β-catenin pathway by targeting the E-cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma.

    PubMed

    Cong, Ningning; Du, Ping; Zhang, Anling; Shen, Fajuan; Su, Juan; Pu, Peiyu; Wang, Tao; Zjang, Jie; Kang, Chunsheng; Zhang, Qingyu

    2013-04-01

    In a previous study, we found that microRNA (miRNA)-200a suppresses Wnt/β-catenin signaling by interacting with β-catenin, thereby inhibiting migration, invasion and proliferation. However, the mechanism involved in this suppression remains unclear. In the present study, we investigated the underlying mechanism of miR-200a regulation of epithelial-mesenchymal transition (EMT) in gastric carcinoma cells, and confirmed the tumor suppressor role of miR-200a in vivo. The expressions of miRNA-200a, -200b and -200c, identified by fluorescent in situ hybridization, were downregulated and inversely correlated with WHO grades of gastric adenocarcinoma (GA). The expression of the potential miR-200a target genes ZEB1 and ZEB2 was detected immunohistochemically. These examinations used the same tissue microarrays to analyze the relationships between miR-200a and potential target genes. The expression of miR-200a and ZEB1/ZEB2 in the same GA tissue microarrays was inversely related. Restored miR-200a expression inhibited tumor growth in nude mice harboring subcutaneous SGC7901 xenografts. The expression of N-cadherin, β-catenin, Twist1 and Snail2 decreased, and E-cadherin levels increased, when miR-200a was elevated, as tested by fluorescence microscopy and immunohistochemistry. Similar results were observed in vivo. We found upregulated miR-200a expression to increase E-cadherin and suppress the Wnt/β-catenin pathway by targeting ZEB1 and ZEB2 in GA, thus delaying tumor growth in vivo. The effect of miR-200a on Wnt/β-catenin signaling may provide a therapeutic target against EMT.

  1. The Tetraindole SK228 Reverses the Epithelial-to-Mesenchymal Transition of Breast Cancer Cells by Up-Regulating Members of the miR-200 Family

    PubMed Central

    Wang, Chie-Hong; Chen, Chia-Ling; More, Shivaji V.; Hsiao, Pei-Wen; Hung, Wen-Chun; Li, Wen-Shan

    2014-01-01

    The results of recent studies have shown that metastasis, the most common malignancy and primary cause of mortality promoted by breast cancer in women, is associated with the epithelial-to-mesenchymal transition (EMT). The results of the current study show that SK228, a novel indole containing substance, exhibits anti-cancer activity. In addition, the effects of SK228 on the regulation of EMT in breast cancer cells as well as the underlying mechanism have been explored. SK228 was observed to induce a fibroblastoid to epithelial-like change in the appearance of various breast cancer cell lines and to suppress the migration and invasion of these cancer cells in vitro. Moreover, expression of E-cadherin was found to increase following SK228 treatment whereas ZEB1 expression was repressed. Expression of other major EMT inducers, including ZEB2, Slug and Twist1, is also repressed by SK228 as a consequence of up-regulation of members of the miR-200 family, especially miR-200c. The results of animal studies demonstrate that SK228 treatment leads to effective suppression of breast cancer growth and metastasis in vivo. The observations made in this investigation show that SK228 reverses the EMT process in breast cancer cells via an effect on the miR-200c/ZEB1/E-cadherin signalling pathway. In addition, the results of a detailed analysis of the in vivo anti-cancer activities of SK228, carried out using a breast cancer xenograft animal model, show that this substance is a potential chemotherapeutic agent for the treatment of breast cancer. PMID:24967704

  2. 9 CFR 592.200 - Debarment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION VOLUNTARY INSPECTION OF EGG PRODUCTS Denial of Service § 592.200 Debarment. (a) The following acts... application for any service or appeal; (ii) The making of the product accessible for sampling or...

  3. 17 CFR 200.10 - The Commission.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false The Commission. 200.10 Section... The Commission. The Commission is composed of five members, not more than three of whom may be members of the same political party. The members are appointed by the President, with the advice and...

  4. 7 CFR 1435.200 - Information reporting.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Recordkeeping Requirements § 1435.200 Information reporting. (a) Every sugar beet processor, sugarcane processor... determining whether processors of sugarcane or sugar beets will be able to market their respective sugar allocations. (d) Each sugarcane producer located in Louisiana shall report, in the manner CCC...

  5. 40 CFR 6.200 - General requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Environmental Review Procedures § 6.200 General requirements. (a) The Responsible Official must determine... determine the scope of the environmental review by considering the type of proposed action, the reasonable... CFR 1508.25. (c) During the environmental review process, the Responsible Official must: (1)...

  6. 40 CFR 6.200 - General requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Environmental Review Procedures § 6.200 General requirements. (a) The Responsible Official must determine... determine the scope of the environmental review by considering the type of proposed action, the reasonable... CFR 1508.25. (c) During the environmental review process, the Responsible Official must: (1)...

  7. 23 CFR 971.200 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... SYSTEMS Forest Highway Program Management Systems § 971.200 Purpose. The purpose of this subpart is to... management agency, to the extent appropriate, to develop by rule safety, bridge, pavement, and congestion management systems for roads funded under the FLHP....

  8. 23 CFR 972.200 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... MANAGEMENT SYSTEMS Fish and Wildlife Service Management Systems § 972.200 Purpose. The purpose of this... Federal land management agency, to the extent appropriate, to develop by rule safety, bridge, pavement, and congestion management systems for roads funded under the FLHP....

  9. 23 CFR 970.200 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... MANAGEMENT SYSTEMS National Park Service Management Systems § 970.200 Purpose. The purpose of this subpart is... Federal land management agency, to the extent appropriate, to develop by rule safety, bridge, pavement, and congestion management systems for roads funded under the FLHP. These management systems serve...

  10. 23 CFR 970.200 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... MANAGEMENT SYSTEMS National Park Service Management Systems § 970.200 Purpose. The purpose of this subpart is... Federal land management agency, to the extent appropriate, to develop by rule safety, bridge, pavement, and congestion management systems for roads funded under the FLHP. These management systems serve...

  11. 23 CFR 972.200 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... MANAGEMENT SYSTEMS Fish and Wildlife Service Management Systems § 972.200 Purpose. The purpose of this... Federal land management agency, to the extent appropriate, to develop by rule safety, bridge, pavement, and congestion management systems for roads funded under the FLHP....

  12. 23 CFR 973.200 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... appropriate, to develop by rule safety, bridge, pavement, and congestion management systems for roads funded... HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL LANDS HIGHWAYS MANAGEMENT SYSTEMS PERTAINING... Management Systems § 973.200 Purpose. The purpose of this subpart is to implement 23 U.S.C. 204...

  13. 23 CFR 971.200 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... SYSTEMS Forest Highway Program Management Systems § 971.200 Purpose. The purpose of this subpart is to... management agency, to the extent appropriate, to develop by rule safety, bridge, pavement, and congestion management systems for roads funded under the FLHP....

  14. 23 CFR 973.200 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... appropriate, to develop by rule safety, bridge, pavement, and congestion management systems for roads funded... HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL LANDS HIGHWAYS MANAGEMENT SYSTEMS PERTAINING... Management Systems § 973.200 Purpose. The purpose of this subpart is to implement 23 U.S.C. 204...

  15. 23 CFR 973.200 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... appropriate, to develop by rule safety, bridge, pavement, and congestion management systems for roads funded... HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL LANDS HIGHWAYS MANAGEMENT SYSTEMS PERTAINING... Management Systems § 973.200 Purpose. The purpose of this subpart is to implement 23 U.S.C. 204...

  16. 23 CFR 973.200 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... appropriate, to develop by rule safety, bridge, pavement, and congestion management systems for roads funded... HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL LANDS HIGHWAYS MANAGEMENT SYSTEMS PERTAINING... Management Systems § 973.200 Purpose. The purpose of this subpart is to implement 23 U.S.C. 204...

  17. 23 CFR 972.200 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... MANAGEMENT SYSTEMS Fish and Wildlife Service Management Systems § 972.200 Purpose. The purpose of this... Federal land management agency, to the extent appropriate, to develop by rule safety, bridge, pavement, and congestion management systems for roads funded under the FLHP....

  18. 23 CFR 972.200 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... MANAGEMENT SYSTEMS Fish and Wildlife Service Management Systems § 972.200 Purpose. The purpose of this... Federal land management agency, to the extent appropriate, to develop by rule safety, bridge, pavement, and congestion management systems for roads funded under the FLHP....

  19. 23 CFR 971.200 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... SYSTEMS Forest Highway Program Management Systems § 971.200 Purpose. The purpose of this subpart is to... management agency, to the extent appropriate, to develop by rule safety, bridge, pavement, and congestion management systems for roads funded under the FLHP....

  20. 23 CFR 971.200 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... SYSTEMS Forest Highway Program Management Systems § 971.200 Purpose. The purpose of this subpart is to... management agency, to the extent appropriate, to develop by rule safety, bridge, pavement, and congestion management systems for roads funded under the FLHP....

  1. 23 CFR 972.200 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... MANAGEMENT SYSTEMS Fish and Wildlife Service Management Systems § 972.200 Purpose. The purpose of this... Federal land management agency, to the extent appropriate, to develop by rule safety, bridge, pavement, and congestion management systems for roads funded under the FLHP....

  2. 23 CFR 973.200 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... appropriate, to develop by rule safety, bridge, pavement, and congestion management systems for roads funded... HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL LANDS HIGHWAYS MANAGEMENT SYSTEMS PERTAINING... Management Systems § 973.200 Purpose. The purpose of this subpart is to implement 23 U.S.C. 204...

  3. 23 CFR 971.200 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... SYSTEMS Forest Highway Program Management Systems § 971.200 Purpose. The purpose of this subpart is to... management agency, to the extent appropriate, to develop by rule safety, bridge, pavement, and congestion management systems for roads funded under the FLHP....

  4. 17 CFR 200.401 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... on behalf of the Commission where such deliberations determine or result in the joint conduct or... 200.401 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Regulations Pertaining to Public Observation of...

  5. 42 CFR 411.200 - Basis.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM EXCLUSIONS FROM MEDICARE AND LIMITATIONS ON MEDICARE PAYMENT Special Rules: Disabled Beneficiaries Who Are Also Covered Under Large Group Health Plans § 411.200 Basis. (a) This subpart is based on...

  6. 42 CFR 411.200 - Basis.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM EXCLUSIONS FROM MEDICARE AND LIMITATIONS ON MEDICARE PAYMENT Special Rules: Disabled Beneficiaries Who Are Also Covered Under Large Group Health Plans § 411.200 Basis. (a) This subpart is based on...

  7. Nuclear Data Sheets for A = 200

    SciTech Connect

    Kondev, F.G.; Lalkovski, S.

    2007-07-15

    Evaluated nuclear structure and decay data for all nuclei within the A = 200 mass chain are presented. This work supersedes the earlier evaluation by M.R. Schmorak (1995Sc23), published in Nuclear Data Sheets 75, 667 (1995). The electron conversion coefficients used in the present evaluation are from 2005KiZW.

  8. 24 CFR 200.215 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Participation Review and Clearance Procedure § 200.215 Definitions. (a) Affiliate. Any person or business... affiliate. Persons and business concerns controlled by the same third party are also affiliates. (b) Felony... furnish advisory services in connection with the financing or construction of a project and the...

  9. 27 CFR 9.200 - Mokelumne River.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Mokelumne River. 9.200... Mokelumne River. (a) Name. The name of the viticultural area described in this section is “Mokelumne River”. For purposes of part 4 of this chapter, “Mokelumne River” and “Mokelumne” are terms of...

  10. 23 CFR 810.200 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PUBLIC TRANSPORTATION MASS TRANSIT AND SPECIAL USE HIGHWAY PROJECTS Making Highway Rights-of-Way Available for Mass Transit Projects § 810.200 Purpose. The... to authorize a State to make available to a publicly-owned mass transit authority existing...

  11. FY 2003 Top 200 Users Survey Report

    DTIC Science & Technology

    2003-08-01

    rating of 90 percent. This may be because we have been unable to print brochures and announcements. Comparative Analysis on Effectiveness of Corporate ... Communication FY 2001 Top 200 Users Survey Strongly Agree or Agree Strongly Disagree or Disagree No Opinion New Product/ Service 92 2 6 Product

  12. 23 CFR 810.200 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PUBLIC TRANSPORTATION MASS TRANSIT AND SPECIAL USE HIGHWAY PROJECTS Making Highway Rights-of-Way Available for Mass Transit Projects § 810.200 Purpose. The... to authorize a State to make available to a publicly-owned mass transit authority existing...

  13. 23 CFR 810.200 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PUBLIC TRANSPORTATION MASS TRANSIT AND SPECIAL USE HIGHWAY PROJECTS Making Highway Rights-of-Way Available for Mass Transit Projects § 810.200 Purpose. The... to authorize a State to make available to a publicly-owned mass transit authority existing...

  14. 23 CFR 810.200 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PUBLIC TRANSPORTATION MASS TRANSIT AND SPECIAL USE HIGHWAY PROJECTS Making Highway Rights-of-Way Available for Mass Transit Projects § 810.200 Purpose. The... to authorize a State to make available to a publicly-owned mass transit authority existing...

  15. 23 CFR 810.200 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PUBLIC TRANSPORTATION MASS TRANSIT AND SPECIAL USE HIGHWAY PROJECTS Making Highway Rights-of-Way Available for Mass Transit Projects § 810.200 Purpose. The... to authorize a State to make available to a publicly-owned mass transit authority existing...

  16. 34 CFR 200.8 - Assessment reports.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... assessment is given; (ii) In an understandable and uniform format, including an alternative format (e.g... understand. (b) Itemized score analyses for LEAs and schools. (1) A State's academic assessment system must produce and report to LEAs and schools itemized score analyses, consistent with § 200.2(b)(4), so...

  17. 34 CFR 200.8 - Assessment reports.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... assessment is given; (ii) In an understandable and uniform format, including an alternative format (e.g... understand. (b) Itemized score analyses for LEAs and schools. (1) A State's academic assessment system must produce and report to LEAs and schools itemized score analyses, consistent with § 200.2(b)(4), so...

  18. 34 CFR 200.8 - Assessment reports.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... assessment is given; (ii) In an understandable and uniform format, including an alternative format (e.g... understand. (b) Itemized score analyses for LEAs and schools. (1) A State's academic assessment system must produce and report to LEAs and schools itemized score analyses, consistent with § 200.2(b)(4), so...

  19. 24 CFR 891.200 - Applicability.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... SUPPORTIVE HOUSING FOR THE ELDERLY PROGRAM AND SECTION 811 SUPPORTIVE HOUSING FOR PERSONS WITH DISABILITIES PROGRAM) SUPPORTIVE HOUSING FOR THE ELDERLY AND PERSONS WITH DISABILITIES Section 202 Supportive Housing for the Elderly § 891.200 Applicability. The requirements set forth in this subpart B apply to...

  20. 38 CFR 52.200 - Physical environment.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2012-07-01 2012-07-01 false Physical environment. 52...) PER DIEM FOR ADULT DAY HEALTH CARE OF VETERANS IN STATE HOMES Standards § 52.200 Physical environment. The physical environment must be designed, constructed, equipped, and maintained to protect the...