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Sample records for 7th century bc

  1. Massartu: The Observation of Astronomical Phenomena in Assyria (7th Century BC)

    NASA Astrophysics Data System (ADS)

    Fales, F. M.

    2011-06-01

    The term massartu is well attested in letters in cuneiform to and from the Neo-Assyrian court, written in the main in the 7th century BC. In itself, massartu is a general Akkadian term, meaning "watch, guard", but in the early 1st millennium BC it takes on two interesting semantic specializations, both of which are tied to the practical and political needs of the Assyrian empire. In astrological-astronomical terms, massartu denotes the wake, vigil, or watch for astronomical observations on the part of the court specialists: such a wake was required by the Assyrian king on a nightly basis, for the subsequent consultation of the vast compilation of omens called Enūma Anu Enlil, and the drawing of conclusions relating to the state of the empire and of the royal dynasty. Many interesting texts show us the workings of the massartu in the capital city Nineveh or in other cities of Mesopotamia. But massartu had also a wider meaning, "vigilance", which denoted the requirement, on the part of all the subjects of the king of Assyria, to keep their eyes and ears open, so as to be able to report to the king if anything untoward was taking place, whether in the capital city or in the most remote military outpost of the empire. Thus, in a way, the astrologers were expected to perform no more and no less than the collective duty of "vigilance" on behalf of the king-but with their eyes trained on the heavens, and in await for signs ultimately sent from the gods.

  2. Alloy characterization of a 7th Century BC archeological bronze vase - Overcoming patina constraints using Monte Carlo simulations

    NASA Astrophysics Data System (ADS)

    Manso, M.; Schiavon, N.; Queralt, I.; Arruda, A. M.; Sampaio, J. M.; Brunetti, A.

    2015-05-01

    In this work we evaluate the composition of a bronze alloy using X-ray fluorescence spectrometry (XRF) and Monte Carlo (MC) simulations. For this purpose, a 7th Century BC archeological vase from the SW Iberian Peninsula, displaying a well formed corrosion patina was analyzed by means of a portable X-ray fluorescence spectrometer. Realistic MC simulations of the experimental setup were performed with the XRMC code package which is based on an intensive use of variance-reduction techniques and uses XRAYLIB a constantly updated X-ray library of atomic data. A single layer model was applied for simulating XRF of polished/pristine bronze whereas a two-or-three-layer model was developed for bronze covered respectively by a corrosion patina alone or coupled with a superficial soil derived crust. These simulations took into account corrosion (cerussite (PbCO3), cuprite (Cu2O), malachite (Cu2CO3(OH)2), litharge (PbO)) and soil derived products (goethite (FeO(OH)) and quartz (SiO2)) identified by means of X-ray diffraction and Raman micro analytical techniques. Results confirm previous research indicating that the XRF/Monte Carlo protocol is well suited when a two-layered model is considered, whereas in areas where the patina + soil derived products' crust is too thick, X-rays from the alloy substrate are not able to exit the sample. Quantitative results based on MC simulations indicate that the vase is made of a lead-bronze alloy: Mn (0.2%), Fe (1.0%), Cu (81.8%), As (0.5%), Ag (0.6%), Sn (8.0%) and Pb (8.0%).

  3. [A development of Byzantine Christian charities during the 4(th)-7(th) centuries and the birth of the hospital].

    PubMed

    Nam, Sung Hyun

    2015-04-01

    This study aims to examine the beginning and the development of Christian Charities during the 4(th)-6(th) centuries which would eventually result in the birth of the hospital in modern sense in the first half of the 7(th) century. For this purpose, I looked carefully into various primary sources concerning the early Christian institutions for the poor and the sick. Above all, it's proper to note that the first xenodocheion where hospitality was combined with a systematic caring, is concerned with the Trinitarian debate of the 4(th) century. In 356, Eustathios, one of the leaders of homoiousios group, established xenodocheion to care for the sick and the lepers in Sebaste of Armenia, whereas his opponent Aetios, doctor and leader of the heteroousios party, was reckoned to have combined the medical treatment with his clerical activities. Then, Basil of Caesarea, disciple of Eustathios of Sebaste, also founded in 372 a magnificent benevolent complex named 'Basileias' after its founder. I scrupulously analysed several contemporary materials mentioning the charitable institution of Caesarea which was called alternatively katagogia, ptochotropheion, xenodocheion. John Chrysostome also founded several nosokomeia in Constantinople at the end of the 4(th) century and the beginning of the 5(th) century. Apparently, the contemporary sources mention that doctors existed for these Charities, but there is no sufficient proof that these 'Christian Hospitals,' Basileias or nosokomeia of Constantinople were hospitals in modern sense. Imperial constitutions began to mention ptochotropheion, xenodocheion and orphanotropheion since the second half of the 5(th) century and then some Justinian laws evoked nosokomium, brephotrophia, gerontocomia. These laws reveal that 'Christian Hospitals' were well clarified and deeply rooted in Byzantine society already in these periods. And then, new benevolent institutions emerged in the 6(th) century: nosokomeia for a specific class and

  4. Cancer and its Treatment in Main Ancient Books of Islamic Iranian Traditional Medicine (7th to 14th Century AD)

    PubMed Central

    Emami, Seyed Ahmad; Sahebkar, Amirhossein; Tayarani-Najaran, Nilufar; Tayarani-Najaran, Zahra

    2012-01-01

    Abstract Islamic medicine is regarded as a comprehensive medical school with a long, glorious and worldwide reputation. Some of the physicians of this school are famous worldwide and have contributed valuable services to the scientific world. Given the dramatically increasing prevalence of cancer and the relative inefficacy of current medications, there is a great demand for the introduction of effective therapeutic approaches. To this end, integration of traditional medicine with modern medical treatments represents a promising option. In this essay, methods of diagnosis and treatment of cancer have been mentioned from the viewpoint of five famous physicians before the Mongolian attack who used Islamic medicine, namely Rhazes, Akhaveyni, Ahwazi, Avicenna and Jorjani. The ideas discussed dates back to a period between the eighth and fourteenth centuries. PMID:23482830

  5. Kinship and Y-Chromosome Analysis of 7th Century Human Remains: Novel DNA Extraction and Typing Procedure for Ancient Material

    PubMed Central

    Vanek, Daniel; Saskova, Lenka; Koch, Hubert

    2009-01-01

    Aim To develop novel DNA extraction and typing procedure for DNA identification of the 7th century human remains, determine the familiar relationship between the individuals, estimate the Y-chromosome haplogroup, and compare the Y-chromosome haplotype with the contemporary populations. Methods DNA from preserved femur samples was extracted using the modified silica-based extraction technique. Polymerase chain reaction amplification was performed using human identification kits MiniFiler, Identifiler, and Y-filer and also laboratory-developed and validated Y-chromosome short tandem repeat (STR) pentaplexes with short amplicons. Results For 244A, 244B, 244C samples, full autosomal DNA profiles (15 STR markers and Amelogenin) and for 244D, 244E, 244F samples, MiniFiler profiles were produced. Y-chromosome haplotypes consisting of up to 24 STR markers were determined and used to predict the Y-chromosome haplogroups and compare the resulting haplotypes with the current population. Samples 244A, 244B, 244C, and 244D belong to Y-chromosome haplogroup R1b and the samples 244E and 244F to haplogroup G2a. Comparison of ancient haplotypes with the current population yielded numerous close matches with genetic distance bellow 2. Conclusion Application of forensic genetics in archaeology enables retrieving new types of information and helps in data interpretation. The number of successfully typed autosomal and Y-STR loci from ancient specimens in this study is one of the largest published so far for aged samples. PMID:19480023

  6. The dispersion of pederasty and the athletic revolution in sixth-century BC Greece.

    PubMed

    Scanlon, Thomas F

    2005-01-01

    Dorian Crete and Thebes are conventionally seen by ancient sources as the originators of pederasty; modern historians see support for this view in Dorian male-centered militarism and sexual segregation in upbringing. Here athletic culture, including training, nudism, and competition, is argued to be a chief 'trigger' for the emergence of pederasty in Sparta and its relatively rapid spread to other Greek states in the seventh to sixth centuries BC. Athletic nudity, in particular, was not a device to enforce civic egalitarianism, as some have argued, but is a persistently erotic incentive that reinforces hegemonic maleness and advertises the individual's virtuous exercise of restraint. In particular, Sparta is found to be the likely source of generalized athletic nudity combined with open pederasty in the early seventh century BC. Nudism in Greek art is erotically charged and not, as others argue, simply a gender marker in the seventh century. Generalized athletic nudity spread to other Greek states emulating the successful Spartan model by the 'athletic revolution' of the early sixth century. With athletic nudity, open pederasty, again following Sparta, was fostered. PMID:16338890

  7. [The Dynamics of the Composition of mtDNA Haplotypes of the Ancient Population of the Altai Mountains from the Early Bronze Age (3rd Millennium BC) to the Iron Age (2nd-1st Centuries BC)].

    PubMed

    Gubina, M A; Kulikov, I V; Babenko, V N; Chikisheva, T A; Romaschenko, A G; Voevoda, M I; Molodin, V I

    2016-01-01

    The mtDNA polymorphism in representatives of various archaeological cultures of the Developed Bronze Age, Early Scythian, and Hunnish-Sarmatian periods was analyzed (N = 34). It detected the dominance of Western-Eurasian haplotypes (70.6%) in mtDNA samples from the representatives of the ancient population of the Early Bronze Age--Iron Age on the territory of Altai Mountains. Since the 8th to the 7th centuries BC, a sharp increase was revealed in the Eastern-Eurasian haplogroups A, D, C, andZ (43.75%) as compared to previous cultures (16.7%). The presence of haplotype 223-242-290-319 of haplogroup A8 in Dolgans, Itelmens, Evens, Koryaks, and Yakuts indicates the possible long-term presence of its carriers in areas inhabited by these populations. The prevalence of Western-Eurasian haplotypes is observed not only in the Altai Mountains but also in Central Asia (Kazakhstan) and the South of the Krasnoyarsk Krai. All of the three studied samples from the Western-Eurasian haplogroups were revealed to contain U, H, T, and HV. The ubiquitous presence of haplotypes of haplogroup H and some haplogroups of cluster U (U5al, U4, U2e, and K) in the vast territory from the Yenisei River basin to the Atlantic Ocean may indicate the direction of human settlement, which most likely occurred in the Paleolithic Period from Central Asia. PMID:27183799

  8. PIXE analysis of jewels from an Achaemenid tomb (IVth century BC)

    NASA Astrophysics Data System (ADS)

    Querré, G.; Bouquillon, A.; Calligaro, T.; Dubus, M.; Salomon, J.

    1996-04-01

    Ion beam analysis has seldom been applied to gemmology. The privileged location of the Laboratoire de recherche des musées de France, close to some of the most prestigious art collections, along with the implementation of the AGLAE IBA facility, have allowed us to initiate several gemmological research programs since 1991. The latest of these deals with a series of Achaemenid jewels (IVth century BC) exhibited in the Louvre museum. The aim of the present research is three-fold: determination of the coloured materials inlayed in gold, composition of the golden alloys and the inlay fixation technique. Analyses have been carried out by PIXE using an external proton beam under conditions set from test experiments on reference gemstones in order to optimise the experimental parameters. Quantitative chemical analysis of both major and trace elements has allowed us to distinguish between 15 types of fine or ornamental stones as well as man-made materials and to identify a peculiar cement technique. We will describe the analytical procedure in detail, then present the main results obtained on coloured inlays and cement and underline a potential drawback of the technique, i.e. a transient colour variation of the target under the impact of the beam, which needs further investigation.

  9. Dynamics of the properties of steppe paleosols of the Sarmatian time (2nd century BC-4th century AD) in relation to secular variations in climatic humidity

    NASA Astrophysics Data System (ADS)

    Demkin, V. A.; Zolotareva, B. N.; Demkina, T. S.; Khomutova, T. E.; Kashirskaya, N. N.; El'Tsov, M. V.; Udal'Tsov, S. N.

    2012-02-01

    Paleosols buried under kurgans of the Early (2nd-1st centuries BC), Middle (1st-2nd centuries AD) and Late (2nd-IV centuries AD) Sarmatian epochs were studied in dry steppes and desert steppes of the Lower Volga region (the Privolzhskaya and Ergeni Uplands and the Caspian Lowland). It was found that temporal variations in the morphological, chemical, microbiological, and magnetic properties of the paleosols in the interval of 2200-1600 BP were characterized by the cyclic pattern related to secular dynamics of climatic humidity with changes in the mean annual precipitation of ±30-50 mm. These climate changes did not transform chestnut paleosols and paleosolonetzes at the type or subtype taxonomic levels. However, they led to certain changes in the humus, carbonate, and salt profiles of the soils; in the character of solonetzic horizon B1; and in the state of microbial communities. According to these data, the Sarmatian time was characterized by alternation of micropluvial and microarid stages lasting fro about 100-200 years. In particular, the stages of humidization were observed in the 1st century BC-1st century AD and in the 4th century AD; the most arid conditions were observed in the second half of the 2nd and the first half of the 3rd century AD.

  10. "Half a Century of Evolution of Neonatology: A Witness's Story" : Dr. K. C. Chaudhuri Lifetime Achievement Award Oration Delivered at AIIMS, New Delhi on 7th September 2014.

    PubMed

    Vidyasagar, Dharmapuri

    2015-12-01

    Lifetime achievement awards are awarded to recognize contributions during the career of an individual, rather than for a single or multiple contributions of a person in his/her field of specialty. I am highly honored being the recipient of the Dr. K. C. Chaudhuri Lifetime Achiement Award Oration. The award for me is significant for several reasons: First being associated with legendary figure such as Dr. Chaudhuri, secondly being recognized by my fellow Indian colleagues. Finally, it also marks half a century of my experience in development of subspecialty of neonatology in US. Some fifty and odd years ago, as an young novice from India I joined the mainstream of this evolution, thanks to my professors and mentors in US and thanks to America, the land of opportunity. During this odyssey, I met many great men and women of science and intellect, saw great scientific discoveries, many innovations, combined with social changes that led to significant reduction of neonatal mortality rates in the industrialized Western countries. I also saw the "Globalization" of "Modern Neonatology" in which I participated with vigor; thus, improving the newborn care in four corners of the world. I am proud that I had the opportunity to contribute a little to growth of neonatology in US and outside the US. This is the story of my professional life. The message of my life story for the younger generation is : Dream big, never give up your dreams. Hardwork, maintaining your integrity, and honesty are the three precepts that will define your character and you will be rewarded in the long run. PMID:26238240

  11. Hesiod (eighth century BC)

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    Greek epic poet who described his cosmology in Theogeny, the birth of the gods, which he derived from Babylonian mythology. In his family tree of the gods, Chaos (the yawning gap between Earth and Heaven) produced Erebus (the Abyss) and Night, who produced Ether and Day. At the same time, Earth produced the Heavens, Mountains, and Sea. The Heavens and Earth then produced Cronos. This family tree...

  12. Archelaus (fifth century BC)

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    Greek philosopher and cosmologist. Pupil of ANAXAGORAS and teacher of Socrates, Archelaus believed that air is the primitive substance, which formed water at the center of the universe. Part condensed to Earth, pieces of which broke off to become the stars....

  13. Secular changes in the height of the inhabitants of Anatolia (Turkey) from the 10th millennium B.C. to the 20th century A.D.

    PubMed

    Ozer, Başak Koca; Sağır, Mehmet; Ozer, Ismail

    2011-03-01

    We use human-skeleton samples to estimate the height of adults living in Anatolia during the Neolithic period. We also report the results of surveys taken in the 20th century on the height of the Turkish population. Neolithic and the Chalcolithic (5000-3000 B.C.) male heights are estimated as 170.9 cm and 165.0 cm, respectively. Pronounced increases were observed for both sexes between the Chalcolithic and Iron (1000-580 B.C.) periods and sharp decreases among both males and females in the Hellenistic-Roman period (333 B.C. to 395 A.D.). Moreover, recovery to the Iron Age levels was achieved in the Anatolian Medieval period (395-1453 A.D.) for both sexes (169.4 cm for males and 158.0 cm for females). In 1884 the mean height of men was 162.2 cm and by the beginning of the 1930s it increased to 166.3 cm. In the first nationwide survey in 1937 males mean height was 165.3 cm, and females was 152.3 cm, where today current heights are 174.0 cm and 158.9 cm, respectively. PMID:21316315

  14. 7th International Meshing Roundtable '98

    SciTech Connect

    Eldred, T.J.

    1998-10-01

    The goal of the 7th International Meshing Roundtable is to bring together researchers and developers from industry, academia, and government labs in a stimulating, open environment for the exchange of technical information related to the meshing process. In the past, the Roundtable has enjoyed significant participation from each of these groups from a wide variety of countries.

  15. Analysis of archaeological triacylglycerols by high resolution nanoESI, FT-ICR MS and IRMPD MS/MS: Application to 5th century BC-4th century AD oil lamps from Olbia (Ukraine)

    NASA Astrophysics Data System (ADS)

    Garnier, Nicolas; Rolando, Christian; Høtje, Jakob Munk; Tokarski, Caroline

    2009-07-01

    This work presents the precise identification of triacylglycerols (TAGs) extracted from archaeological samples using a methodology based on nanoelectrospray and Fourier transform mass spectrometry. The archaeological TAG identification needs adapted sample preparation protocols to trace samples in advanced degradation state. More precisely, the proposed preparation procedure includes extraction of the lipid components from finely grinded ceramic using dichloromethane/methanol mixture with additional ultrasonication treatment, and TAG purification by solid phase extraction on a diol cartridge. Focusing on the analytical approach, the implementation of "in-house" species-dependent TAG database was investigated using MS and InfraRed Multiphoton Dissociation (IRMPD) MS/MS spectra; several vegetal oils, dairy products and animal fats were studied. The high mass accuracy of the Fourier transform analyzer ([Delta]m below 2.5 ppm) provides easier data interpretation, and allows distinction between products of different origins. In details, the IRMPD spectra of the lithiated TAGs reveal fragmentation reactions including loss of free neutral fatty acid and loss of fatty acid as [alpha],[beta]-unsaturated moieties. Based on the developed preparation procedure and on the constituted database, TAG extracts from 5th century BC to 4th century AD Olbia lamps were analyzed. The structural information obtained succeeds in identifying that bovine/ovine fats were used as fuel used in these archaeological Olbia lamps.

  16. Leucippus (fl. fifth century BC)

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    Philosopher, born in Miletus, Asia Minor. Virtually nothing is known of his life, except that he was the founder of Atomism, developed by his disciple DEMOCRITUS and accessibly presented by LUCRETIUS in De Rerum Natura. Essentially Atomism is a theory to explain change. Atoms are microscopic particles and are permanent. They move in the permanent framework of space and alter their arrangements—ap...

  17. 7th Annual European Antibody Congress 2011

    PubMed Central

    2012-01-01

    The 7th European Antibody Congress (EAC), organized by Terrapin Ltd., was again held in Geneva, Switzerland, following on the tradition established with the 4th EAC. The 2011 version of the EAC was attended by nearly 250 delegates who learned of the latest advances and trends in the global development of antibody-based therapeutics. The first day focused on advances in understanding structure-function relationships, choosing the best format, glycoengineering biobetter antibodies, improving the efficacy and drugability of mAbs and epitope mapping. On the second day, the discovery of novel targets for mAb therapy, clinical pipeline updates, use of antibody combinations to address resistance, generation and identification of mAbs against new targets and biosimilar mAb development were discussed. Antibody-drug conjugates, domain antibodies and new scaffolds and bispecific antibodies were the topics of the third day. In total, nearly 50 speakers provided updates of programs related to antibody research and development on-going in the academic, government and commercial sectors. PMID:22453093

  18. Paleosols and climate in the southeast of the Central Russian Upland during the Middle and Late Bronze ages (the 25th-15th Centuries BC)

    NASA Astrophysics Data System (ADS)

    Demkin, V. A.; Borisov, A. V.; Udal'Tsov, S. N.

    2010-01-01

    Paleosol studies of kurgans dating back to the Middle and Late Bronze ages (the Catacomb, Pokrovskaya, and Srubnaya cultural epochs; 4500-3500 BP) have been performed within the dry steppe zone in the southeast of the Central Russian Upland. The studied kurgans occupy the upper parts of local interfluves differing in the lithology of their upper horizons. The specificity of the Middle Holocene pedogenesis as related to the local lithologic and geomorphic conditions has been characterized. During the past 4500 years, local soils have been subjected to evolutionary changes related to climatic fluctuations. These changes manifested themselves at the subtype level with substitution of dark chestnut soils for chestnut soils. The climatic conditions during the Catacomb and Pokrovskaya cultural epochs (4.5-3.8 ka BP) were more arid than those at present. The maximum aridization of the climate took place at the end of the third and the first quarter of the second millennia BC. Detailed descriptions of the morphology of kurgan bodies and buried paleosols make it possible to hypothesize about the seasons of the kurgan construction and the technology of this work.

  19. Concept Mapping Improves Metacomprehension Accuracy among 7th Graders

    ERIC Educational Resources Information Center

    Redford, Joshua S.; Thiede, Keith W.; Wiley, Jennifer; Griffin, Thomas D.

    2012-01-01

    Two experiments explored concept map construction as a useful intervention to improve metacomprehension accuracy among 7th grade students. In the first experiment, metacomprehension was marginally better for a concept mapping group than for a rereading group. In the second experiment, metacomprehension accuracy was significantly greater for a…

  20. Meeting Report: 7th World Congress on Itch

    PubMed Central

    Azimi, Ehsan; Lerner, Ethan A.

    2014-01-01

    The 7th World Congress on Itch was held in Boston in September 2013. This is the biennial meeting of the International Forum for the Study of Itch (IFSI), www.itchforum.net, There were 240 attendees from 17 countries. They spanned clinical practice, academics and patient advocacy while the opportunity for translation was demonstrated as 80 attendees were from industry. A large academic neuroscience contingent was present. There were plenary sessions, basic and clinical tracts, and sixty posters during the 2½ day meeting. The meeting program and 160 abstracts are available at www.itchboston.org and the open access journal, Acta Dermato-Venereologica, www.medicaljournals.se/acta/. This report highlights selected aspects of the congress and the latest advances in the field. PMID:24924756

  1. Geocost-Bc

    1981-03-24

    GEOCOST calculates the cost of generating electricity from geothermal energy. The version of GEOCOST in this release, GEOCOST-BC, simulates the production of electricity using a binary fluid cycle based upon a hydrothermal resource.

  2. 7th IGRSM International Remote Sensing & GIS Conference and Exhibition

    NASA Astrophysics Data System (ADS)

    Shariff, Abdul Rashid Mohamed

    2014-06-01

    IGRSM This proceedings consists of the peer-reviewed papers from the 7th IGRSM International Conference and Exhibition on Remote Sensing & GIS (IGRSM 2014), which was held on 21-22 April 2014 at Berjaya Times Square Hotel, Kuala Lumpur, Malaysia. The conference, with the theme Geospatial Innovation for Nation Building was aimed at disseminating knowledge, and sharing expertise and experiences in geospatial sciences in all aspects of applications. It also aimed to build linkages between local and international professionals in this field with industries. Highlights of the conference included: Officiation by Y B Datuk Dr Abu Bakar bin Mohamad Diah, Deputy Minister of Minister of Science, Technology & Innovation Keynote presentations by: Associate Professor Dr Francis Harvey, Chair of the Geographic Information Science Commission at the International Geographical Union (IGU) and Director of U-Spatial, University of Minnesota, US: The Next Age of Discovery and a Future in a Post-GIS World. Professor Dr Naoshi Kondo, Bio-Sensing Engineering, University of Kyoto, Japan: Mobile Fruit Grading Machine for Precision Agriculture. Datuk Ir Hj Ahmad Jamalluddin bin Shaaban, Director-General, National Hydraulic Research Institute of Malaysia (NAHRIM), Malaysia: Remote Sensing & GIS in Climate Change Analyses. Oral and poster presentations from 69 speakers, from both Malaysia (35) and abroad (34), covering areas of water resources management, urban sprawl & social mobility, agriculture, land use/cover mapping, infrastructure planning, disaster management, technology trends, environmental monitoring, atmospheric/temperature monitoring, and space applications for the environment. Post-conference workshops on: Space Applications for Environment (SAFE), which was be organised by the Japan Aerospace Exploration Agency (JAXA) Global Positioning System (GPS) Receiver Evaluation Using GPS Simulation, which was be organised by the Science & Technology Research Institute for Defence

  3. The 7th International Workshop on Chiral Dynamics

    NASA Astrophysics Data System (ADS)

    The 7th International Workshop Chiral Dynamics: Theory and Experiment (CD12) took place at Jefferson Lab, Newport News, Virginia, USA, from August 6 to 10, 2012. Following in the tradition of this triennial series of Conferences, it attracted theorists and experimentalists, who were brought together to highlight the recent progress in the field of low energy QCD, and to discuss and explore the direction for future development. The conference consisted of plenary talks and three working groups. We would like to thank the working group organizers for their dedicated effort, namely: Goldstone Bosons: Mario Antonelli, Liping Gan, Jorge Portoles and Urs Wenger; Hadron Structure: Alessandro Bacchetta, Bastian Kubis, Kostas Orginos and Karl Slifer and Few Body Physics: Andreas Nogga, Assumpta Parreno, Michele Viviani and Henry Weller. We would like to express our special thanks to our co-organizers, Patricia Solvignon, Harald Griesshammer, Rocco Schiavilla, Dinko Pocanic, Robert Edwards, and Alexandre Deur for their hard work and advice. Last but not least, we thank the International Advisory Committee for their very useful inputs to the CD12 program. The organizers thank the excellent logistic and administrative support provided by the Jefferson Lab Conference Staff, Ruth Bizot, Cynthia Lockwood, Stephanie Vermeire, Marti Hightower and MeLaina Evans, and the Conference Secretary Mary Fox, which was instrumental for the success of the organization of CD12. We thank Joanna Griffin for the poster design. CD12 was primarily sponsored by Jefferson Lab, along with generous supports from Old Dominion University and the European Physics Journal. The CD12 homepage is located at http://www.jlab.org/conference/CD12 The upcoming Chiral Dynamics Workshop will take place in Pisa, Italy, in 2015. We thank Laura Marcucci and Michele Viviani for graciously taking the baton from us. Jose Goity and Jianping Chen

  4. PREFACE: 7th EEIGM International Conference on Advanced Materials Research

    NASA Astrophysics Data System (ADS)

    Joffe, Roberts

    2013-12-01

    The 7th EEIGM Conference on Advanced Materials Research (AMR 2013) was held at Luleå University of Technology on the 21-22 March 2013 in Luleå, SWEDEN. This conference is intended as a meeting place for researchers involved in the EEIGM programme, in the 'Erasmus Mundus' Advanced Materials Science and Engineering Master programme (AMASE) and the 'Erasmus Mundus' Doctoral Programme in Materials Science and Engineering (DocMASE). This is great opportunity to present their on-going research in the various fields of Materials Science and Engineering, exchange ideas, strengthen co-operation as well as establish new contacts. More than 60 participants representing six countries attended the meeting, in total 26 oral talks and 19 posters were presented during two days. This issue of IOP Conference Series: Materials Science and Engineering presents a selection of articles from EEIGM-7 conference. Following tradition from previous EEIGM conferences, it represents the interdisciplinary nature of Materials Science and Engineering. The papers presented in this issue deal not only with basic research but also with applied problems of materials science. The presented topics include theoretical and experimental investigations on polymer composite materials (synthetic and bio-based), metallic materials and ceramics, as well as nano-materials of different kind. Special thanks should be directed to the senior staff of Division of Materials Science at LTU who agreed to review submitted papers and thus ensured high scientific level of content of this collection of papers. The following colleagues participated in the review process: Professor Lennart Walström, Professor Roberts Joffe, Professor Janis Varna, Associate Professor Marta-Lena Antti, Dr Esa Vuorinen, Professor Aji Mathew, Professor Alexander Soldatov, Dr Andrejs Purpurs, Dr Yvonne Aitomäki, Dr Robert Pederson. Roberts Joffe October 2013, Luleå Conference photograph EEIGM7 conference participants, 22 March 2013 The PDF

  5. PREFACE: 7th European Conference on Applied Superconductivity (EUCAS '05)

    NASA Astrophysics Data System (ADS)

    Weber, Harald W.; Sauerzopf, Franz M.

    2006-07-01

    This issue of Journal of Physics: Conference Series contains those contributed papers that were submitted to the Conference Proceedings of the 7th European Conference on Applied Superconductivity (EUCAS '05) on 11 - 15 September 2005. The plenary and invited papers were published in the journal Superconductor Science and Technology 19 2006 (March issue). The scientific aims of EUCAS '05 followed the tradition established at the preceding conferences in Göttingen, Edinburgh, Eindhoven, Sitges (Barcelona), Lyngby (Copenhagen) and finally Sorrento (Napoli). The focus was placed on the interplay between the most recent developments in superconductor research and the positioning of applications of superconductivity in the marketplace. Although initially founded as an exchange forum mainly for European scientists, it has gradually developed into a truly international meeting with significant attendance from the Far East and the United States. The Vienna conference attracted 813 participants in the scientific programme and 90 guests: of the particpants 59% were from Europe, 31% from the Far East, 6% from the United States and Canada and 4% from other nations worldwide. There were 32 plenary and invited lectures highlighting the state-of-the-art in the areas of materials, large-scale and small-scale applications, and 625 papers were contributed (556 of these were posters) demonstrating the broad range of exciting activities in all research areas of our field. A total of 27 companies presented their most recent developments in the field. This volume contains 349 papers, among them 173 on materials (49.6%), 90 on large scale applications (25.8%) and 86 on small scale applications (24.6%). EUCAS '05 generated a feeling of optimism and enthusiasm for this fascinating field of research and for its well established technological potential, especially among the numerous young researchers attending this Conference. We are grateful to all those who participated in the meeting and

  6. BC Jurisdictional Report

    ERIC Educational Resources Information Center

    British Columbia Council on Admissions and Transfer, 2010

    2010-01-01

    This report was submitted by the BC Council on Admissions (BCCAT) to the Council of Ministers of Education, Canada (CMEC). This report is a summary of projects and activities completed by BCCAT during the period from April 1, 2009, to March 31, 2010. The purpose of this report is to inform the Council of Ministers of Education, Canada (CMEC) of…

  7. 3. PHOTOGRAPHIC COPY OF MASTER PLAN, DETAIL SITE PLAN, 7TH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. PHOTOGRAPHIC COPY OF MASTER PLAN, DETAIL SITE PLAN, 7TH CAVALRY BUILDINGS, DATED SEPTEMBER 10, 1951, SEE ARROW, DRAWING # BM-036, COPY ON FILE IN THE ENVIRONMENTAL MANAGEMENT OFFICE, FORT BLISS - Fort Bliss, 7th Cavalry Buildings, U.S. Army Air Defence Artillery Center & Fort Bliss, El Paso, El Paso County, TX

  8. 7th International Conference on Mathematical Methods in Physics

    NASA Astrophysics Data System (ADS)

    Bonora, L.; Bytsenko, A. A.; Guimarães, M. E. X.; Helayël-Neto, J. A.

    The 7th International Conference on Mathematical Methods in Physics took place in the Centro Brasileiro de Pesquisas Físicas (CBPF/MCT), Rio de Janeiro - RJ, Brazil, from 16 to 20 April 2012, and was jointly organized by the following Institutions: Centro Brasileiro de Pesquisas Físicas (CBPF/MCT), The Abdus Salam International Centre for Theoretical Physics (ICTP, Italy), Instituto Nacional de Matemática Pura e Aplicada (IMPA, Brazil), The Academy of Sciences for the Developing World (TWAS, Italy) and The Scuola Internazionale di Studi Avanzati (SISSA,Italy). The Organizing Committees were composed by: E. ABDALLA (USP, Brazil), L. BONORA (SISSA, Italy), H. BURSZTYN (IMPA, Brazil), A. A. BYTSENKO (UEL, Brazil), B. DUBROVIN (SISSA, Italy), M.E.X. GUIMARÃES (UFF, Brazil), J.A. HELAYËL-NETO (CBPF, Brazil). Advisory Committee: A. V. ASHTEKAR (Penn State University, U.S.A.), V. M. BUCHSTABER (Steklov Mathematical Institute, Russia), L. D. FADDEEV (St. Petersburg Dept. of Steklov Mathematical Institute, Russia), I. M. KRICHEVER (Columbia Univ., U.S.A./ Landau Institute of Theoretical Physics, Russia), S. P. NOVIKOV (Univ. of Maryland, U.S.A./Landau Institute of Theoretical Physics, Russia), J. PALIS (IMPA, Brazil), A. QADIR (National University of Sciences and Technology, Pakistan), F. QUEVEDO (ICTP, Italy), S. RANDJBAR-DAEMI (ICTP, Italy), G. THOMPSON (ICTP, Italy), C. VAFA (Harvard University, U.S.A.). The Main Goal: The aim of the Conference was to present the latest advances in Mathematical Methods of Physics to researchers, young scientists and students of Latin America in general, and Brazil in particular, in the areas of High Energy Physics, Cosmology, Mathematical Physics and Applied Mathematics. The main goal was to promote an updating of knowledge and to facilitate the interaction between mathematicians and theoretical physicists, through plenary sessions and seminars. This Conference can be considered as a part of a network activity in a special effort to

  9. 4. General view of streetscape along 7th Street looking east ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. General view of streetscape along 7th Street looking east from Columbia Street. Brewery property on north side of street - George Wiedemann Brewery Complex, Sixth & Columbia Streets, Newport, Campbell County, KY

  10. Proceedings of the 7th International Symposium on the Molecular Breeding of Forage and Turf

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The 7th International Symposium on the Molecular Breeding of Forage and Turf, MBFT2012, was held in Salt Lake City, UT, USA, from 4-7 June 2012. One-hundred and fifteen researchers from around the world presented oral and poster formats relating to ten general topics: Genetic mechanisms and applic...

  11. Assessment of an Engineering Technology Outreach Program for 4th-7th Grade Girls

    ERIC Educational Resources Information Center

    Dell, Elizabeth M.; Christman, Jeanne; Garrick, Robert D.

    2011-01-01

    This paper describes a workshop led by female Engineering Technology students, with support from female faculty, to provide an introduction to Engineering Technology to 4th-7th grade girls through a series of interactive laboratory experiments. This outreach program was developed to improve attitudes towards science and engineering in middle…

  12. The Effects of Animation Technique on the 7th Grade Science and Technology Course

    ERIC Educational Resources Information Center

    Aksoy, Gökhan

    2012-01-01

    The purpose of this study is to determine the effect of animation technique on academic achievement of students in the "Human and Environment" unit lectured as part of the Science and Technology course of the seventh grade in primary education. The sample of the study consists of 58 students attending to the 7th grade of Erzurum MEB…

  13. Recommendations from the Workshop: Environment, Ecology and Sustainable Development ICAE 7th World Assembly

    ERIC Educational Resources Information Center

    Viezzer, Moema L.

    2006-01-01

    One of the workshops presented at the 7th International Council for Adult Education (ICAE) Assembly was focused on environment, ecology, and sustainable development. The workshop had participants from Asia, Africa, Europe, South America, North America and the South Pacific. This article presents a list of recommendations from the workshop.

  14. The Contribution of Morphological Knowledge to 7th Grade Students' Reading Comprehension Performance

    ERIC Educational Resources Information Center

    Mokhtari, Kouider; Neel, Joanna; Matatall, Abbey; Richards, Andrea

    2015-01-01

    In this study, we examined the role of morphology, an important yet largely understudied source of difficulty, in reading ability among 7th grade students in one junior high school in the southwestern United States. We sought to find out how much variance in reading ability is accounted for by these students' morphological knowledge, and whether…

  15. Activities Using The State of the World Atlas, 7th Edition

    ERIC Educational Resources Information Center

    Hegelbach, Peter; Haakenson, Dean; Starbird, Caroline

    2004-01-01

    This book is designed to accompany The State of the World Atlas, 7th Edition. The State of the World Atlas and this workbook provide a frame of reference for the changing pattern of world events. Students will become familiar with different statistical representations of the world, from birth rates to HIV/AIDS infections rates; from world…

  16. Effects of Concept Cartoons on Mathematics Self-Efficacy of 7th Grade Students

    ERIC Educational Resources Information Center

    Sengul, Sare

    2011-01-01

    The purpose of this research is to determine the effect of concept cartoons on the students' perception of their levels of self-efficacy towards mathematics. The research has been designed as the pre-test post-test with quasi experimental control group. The research participants are composed of 94 7th grade students attending an elementary school…

  17. Opinions of 7th Grade Students about Enriched Educational Practices in the Scope of Science Course

    ERIC Educational Resources Information Center

    Idin, Sahin; Aydogdu, Cemil

    2016-01-01

    The purpose of this research was to determine the opinions of the students about 7th grade science courses carried out with enriched educational practices. The research was conducted throughout fall semester of 2014-2015 academic year in the scope of Systems within our Body Unit (SBU), Force and Motion Unit (FMU), and Electric within our Lives…

  18. Conceptions of Mathematics in Different Ability and Achievement Groups among 7th Grade Students

    ERIC Educational Resources Information Center

    Lepmann, Lea; Afanasjev, Juri

    2005-01-01

    This report deals with 7th grade pupils' conceptions of mathematics, its learning and teaching. The report focuses on the identification and comparison of views expressed by pupil groups of different mathematical ability and achievement. The analysis is based on the results of the ability tests, subject tests and a questionnaire conducted among…

  19. 16. TWO HEAD GATES ABOUT 500 FEET NORTH OF 7TH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. TWO HEAD GATES ABOUT 500 FEET NORTH OF 7TH AVENUE (SECTION 35). - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  20. Plato (428-347 BC)

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    Philosopher, real name said to be Aristocles, with `Plato' a nickname (`broad') derived either from the breadth of his knowledge, shoulders, or forehead, born in Athens, Greece, taught by Socrates, and travelled in Egypt, Sicily and Italy. Back in Athens, he founded, in 387 BC, a school of learning called the Academy, devoted to research and instruction in philosophy and the sciences, particularl...

  1. BC Jurisdictional Report for CMEC

    ERIC Educational Resources Information Center

    British Columbia Council on Admissions and Transfer, 2007

    2007-01-01

    The British Columbia Council on Admissions and Transfer (BCCAT) was established to facilitate admission, articulation and transfer arrangements among British Columbia (BC) post-secondary institutions. Each year BCCAT prepares a detailed work plan and at the end of the fiscal year prepares an Annual Report that summarizes what was achieved. Each…

  2. New archaeomagnetic data recovered from the study of Roman and Visigothic remains from central Spain (3rd-7th centuries)

    NASA Astrophysics Data System (ADS)

    Catanzariti, Gianluca; Gómez-Paccard, Miriam; McIntosh, Gregg; Pavón-Carrasco, Francisco J.; Chauvin, Annick; Osete, María. L.

    2012-03-01

    New archaeomagnetic results from four heated/combustion structures recovered from two archaeological sites in central Spain are reported. They have been dated by archaeological evidence and in two cases by radiocarbon dating. Rock magnetic experiments indicate low coercivity magnetic phases, such as magnetite and thermally stable maghaemite, as the main carriers of the remanent magnetization. Haematite has been observed in poorly heated baked clays. Archaeomagnetic directions have been obtained from either alternating field or thermal demagnetization experiments performed on 57 specimens coming from 46 independently oriented samples. The four well-defined archaeomagnetic directions obtained are in good agreement with previous archaeomagnetic data and with recent regional and global field models. They define the beginning of easterly declination drift that was initiated around 350-400 AD and culminated around 800-850 AD, and delineate the maximum in inclination that took place around 600-650 AD. In addition, classical Thellier-Thellier experiments including thermal remanent magnetization anisotropy and cooling rate corrections were conducted on 23 specimens. Only 13 specimens, corresponding to well-defined single component behaviour, gave reliable results. New mean archaeointensities have been obtained for two of the four studied structures (VBK1, 64.2 ± 5.0 μT and VBT1, 62.4 ± 2.6 μT). The new data suggest that two relative intensity maxima occurred in Western Europe around 320 and 630 AD, being of lower magnitude that observed in Eastern Europe.

  3. Mobility histories of 7th-9th century AD people buried at early medieval Bamburgh, Northumberland, England.

    PubMed

    Groves, S E; Roberts, C A; Lucy, S; Pearson, G; Gröcke, D R; Nowell, G; Macpherson, C G; Young, G

    2013-07-01

    Early Medieval England is described historically as a time when people migrated from the Continent to English shores. This study tests the hypothesis that those buried in the Bowl Hole cemetery, Bamburgh, Northumberland were nonlocally born, because of its royal status. Ninety-one male and female adult, and nonadult, skeletons were studied. Isotope ratios of strontium ((87) Sr/(86) Sr) and oxygen (δ(18) O) were generated for 78 individuals (28 females, 27 males, five "adults," 18 nonadults). The mean Sr value for human enamel was 0.71044, standard deviation (sd) 0.001, and the mean O (δw) value is -5.9‰, sd 1.6‰. Additionally, animal tooth enamel (mean Sr value 0.710587, sd 0.001; mean O value -6.5‰, sd 1.5‰), local soil (mean Sr value 0.709184, sd 0.0006), snail shells (mean Sr value 0.708888, sd 0.0001), and soil samples from a 5 km transect heading inland (mean Sr value 0.709121, sd 0.0003), were analyzed for an indication of the isotopic composition of bioavailable Sr in the modern environment and to assess the impact of sea-spray; water samples from a well, local rivers, and standing water were analyzed for local δ(18) O values (mean O value -6.4‰, relative to VSMOW, sd 2.8‰). Over 50% of those buried at Bamburgh were nonlocal. All ages and both sexes produced "nonlocal" signatures; some suggested childhood origins in Scandinavia, the southern Mediterranean or North Africa. Stature and other indicators of health status indicated differences in quality of life between local and migrant groups. These differences did not extend to burial practices. PMID:23737109

  4. EDITORIAL Invited papers from the 7th International Conference on Fine Particle Magnetism 2010 Invited papers from the 7th International Conference on Fine Particle Magnetism 2010

    NASA Astrophysics Data System (ADS)

    Nordblad, Per

    2010-12-01

    This cluster issue of Journal of Physics D: Applied Physics contains a collection of papers based on invited and contributed talks given at the 7th International Conference on Fine Particle Magnetism (ICFPM) held from 21-24 June, 2010 at the Ångström Laboratory, Uppsala University in Sweden. The ICFPM conferences have previously been held in Rome, Italy (1991), Bangor, UK (1996), Barcelona, Spain (1999), Pittsburgh, USA (2002), London, UK (2004) and Rome, Italy (2007); the 8th ICFPM is to be organized in Perpignan, France (2013). The aim of this series of conferences is to bring together experts in the field of fine particle magnetism to discuss recent fundamental experimental and theoretical findings as well as new technological developments and applications. Thus, the conference programme included sessions ranging from basic studies of nanomagnetism to biomedical applications of fine magnetic particles. The local organizers of ICFPM-2010 want to thank the Swedish Research Council (VR), the Center for Nanointegration Duisburg-Essen (CeNIDE) and LOT-Oriel Group Europe for financial support. We also acknowledge Akademikonferens for effective administration of the conference and Uppsala University for support and for providing the venue. Last but not least, we thank all participants for making the conference scientifically interesting and socially enjoyable.

  5. Proceedings from the 7th Annual International Society for Musculoskeletal Imaging in Rheumatology (ISEMIR) conference.

    PubMed

    Troum, Orrin M; Pimienta, Olga L; Schmidt, Wolfgang A; Ostergaard, Mikkel; D'Agostino, Maria Antonietta; Gaylis, Norman; Arnold, William; Ben-Artzi, Ami; Ranganath, Veena; Seraphine, Judy L; Peterfy, Charles

    2015-08-01

    The International Society for Musculoskeletal Imaging in Rheumatology (ISEMIR) was founded in 2005 with the goal of discussing matters related to imaging in rheumatology, particularly, validation, education, and use in clinical practice and research. Because the field of musculoskeletal (MSK) imaging is rapidly evolving, continuous education in the field is imperative. ISEMIR's international faculty and world-renowned experts presented the newest information as it relates to the use of magnetic resonance imaging (MRI) and ultrasound (US) at the 7th annual ISEMIR meeting which took place on April 12-14, 2014 in Santa Monica, California. Presentations from the meeting can be viewed at www.isemir.org. PMID:25908178

  6. Emerging technologies and perspectives for nutrition research in European Union 7th Framework Programme.

    PubMed

    de Froidmont-Görtz, Isabelle B M

    2009-12-01

    Nutrition trends in Europe are driven by taste, health and convenience. The possibilities of research using new technologies and tools such as nutrigenomics, imaging techniques, nanotechnology, bioinformatics, cognitive sciences, innovative processes are very promising to support these nutrition trends and in particular their health aspects. This is supported by European Union research. The opportunities offered in the 7th Framework Programme (FP7), among other innovations, will contribute to the general aim of improving nutrition policy as well as improving products from the food industry in accordance with the Lisbon strategy to create employment and improve the quality of life of the European citizens. PMID:19937440

  7. First Observation of a Baryonic Bc+ Decay

    NASA Astrophysics Data System (ADS)

    Aaij, R.; Adeva, B.; Adinolfi, M.; Affolder, A.; Ajaltouni, Z.; Akar, S.; Albrecht, J.; Alessio, F.; Alexander, M.; Ali, S.; Alkhazov, G.; Alvarez Cartelle, P.; Alves, A. A.; Amato, S.; Amerio, S.; Amhis, Y.; An, L.; Anderlini, L.; Anderson, J.; Andreassen, R.; Andreotti, M.; Andrews, J. E.; Appleby, R. B.; Aquines Gutierrez, O.; Archilli, F.; Artamonov, A.; Artuso, M.; Aslanides, E.; Auriemma, G.; Baalouch, M.; Bachmann, S.; Back, J. J.; Badalov, A.; Baldini, W.; Barlow, R. J.; Barschel, C.; Barsuk, S.; Barter, W.; Batozskaya, V.; Battista, V.; Bay, A.; Beaucourt, L.; Beddow, J.; Bedeschi, F.; Bediaga, I.; Belogurov, S.; Belous, K.; Belyaev, I.; Ben-Haim, E.; Bencivenni, G.; Benson, S.; Benton, J.; Berezhnoy, A.; Bernet, R.; Bettler, M.-O.; van Beuzekom, M.; Bien, A.; Bifani, S.; Bird, T.; Bizzeti, A.; Bjørnstad, P. M.; Blake, T.; Blanc, F.; Blouw, J.; Blusk, S.; Bocci, V.; Bondar, A.; Bondar, N.; Bonivento, W.; Borghi, S.; Borgia, A.; Borsato, M.; Bowcock, T. J. V.; Bowen, E.; Bozzi, C.; Brambach, T.; van den Brand, J.; Bressieux, J.; Brett, D.; Britsch, M.; Britton, T.; Brodzicka, J.; Brook, N. H.; Brown, H.; Bursche, A.; Busetto, G.; Buytaert, J.; Cadeddu, S.; Calabrese, R.; Calvi, M.; Calvo Gomez, M.; Campana, P.; Campora Perez, D.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carson, L.; Carvalho Akiba, K.; Casse, G.; Cassina, L.; Castillo Garcia, L.; Cattaneo, M.; Cauet, Ch.; Cenci, R.; Charles, M.; Charpentier, Ph.; Chefdeville, M.; Chen, S.; Cheung, S.-F.; Chiapolini, N.; Chrzaszcz, M.; Ciba, K.; Cid Vidal, X.; Ciezarek, G.; Clarke, P. E. L.; Clemencic, M.; Cliff, H. V.; Closier, J.; Coco, V.; Cogan, J.; Cogneras, E.; Cojocariu, L.; Collins, P.; Comerma-Montells, A.; Contu, A.; Cook, A.; Coombes, M.; Coquereau, S.; Corti, G.; Corvo, M.; Counts, I.; Couturier, B.; Cowan, G. A.; Craik, D. C.; Cruz Torres, M.; Cunliffe, S.; Currie, R.; D'Ambrosio, C.; Dalseno, J.; David, P.; David, P. N. Y.; Davis, A.; De Bruyn, K.; De Capua, S.; De Cian, M.; De Miranda, J. M.; De Paula, L.; De Silva, W.; De Simone, P.; Decamp, D.; Deckenhoff, M.; Del Buono, L.; Déléage, N.; Derkach, D.; Deschamps, O.; Dettori, F.; Di Canto, A.; Dijkstra, H.; Donleavy, S.; Dordei, F.; Dorigo, M.; Dosil Suárez, A.; Dossett, D.; Dovbnya, A.; Dreimanis, K.; Dujany, G.; Dupertuis, F.; Durante, P.; Dzhelyadin, R.; Dziurda, A.; Dzyuba, A.; Easo, S.; Egede, U.; Egorychev, V.; Eidelman, S.; Eisenhardt, S.; Eitschberger, U.; Ekelhof, R.; Eklund, L.; El Rifai, I.; Elsasser, Ch.; Ely, S.; Esen, S.; Evans, H.-M.; Evans, T.; Falabella, A.; Färber, C.; Farinelli, C.; Farley, N.; Farry, S.; Fay, RF; Ferguson, D.; Fernandez Albor, V.; Ferreira Rodrigues, F.; Ferro-Luzzi, M.; Filippov, S.; Fiore, M.; Fiorini, M.; Firlej, M.; Fitzpatrick, C.; Fiutowski, T.; Fontana, M.; Fontanelli, F.; Forty, R.; Francisco, O.; Frank, M.; Frei, C.; Frosini, M.; Fu, J.; Furfaro, E.; Gallas Torreira, A.; Galli, D.; Gallorini, S.; Gambetta, S.; Gandelman, M.; Gandini, P.; Gao, Y.; García Pardiñas, J.; Garofoli, J.; Garra Tico, J.; Garrido, L.; Gaspar, C.; Gauld, R.; Gavardi, L.; Gavrilov, G.; Geraci, A.; Gersabeck, E.; Gersabeck, M.; Gershon, T.; Ghez, Ph.; Gianelle, A.; Giani', S.; Gibson, V.; Giubega, L.; Gligorov, V. V.; Göbel, C.; Golubkov, D.; Golutvin, A.; Gomes, A.; Gotti, C.; Grabalosa Gándara, M.; Graciani Diaz, R.; Granado Cardoso, L. A.; Graugés, E.; Graziani, G.; Grecu, A.; Greening, E.; Gregson, S.; Griffith, P.; Grillo, L.; Grünberg, O.; Gui, B.; Gushchin, E.; Guz, Yu.; Gys, T.; Hadjivasiliou, C.; Haefeli, G.; Haen, C.; Haines, S. C.; Hall, S.; Hamilton, B.; Hampson, T.; Han, X.; Hansmann-Menzemer, S.; Harnew, N.; Harnew, S. T.; Harrison, J.; He, J.; Head, T.; Heijne, V.; Hennessy, K.; Henrard, P.; Henry, L.; Hernando Morata, J. A.; van Herwijnen, E.; Heß, M.; Hicheur, A.; Hill, D.; Hoballah, M.; Hombach, C.; Hulsbergen, W.; Hunt, P.; Hussain, N.; Hutchcroft, D.; Hynds, D.; Idzik, M.; Ilten, P.; Jacobsson, R.; Jaeger, A.; Jalocha, J.; Jans, E.; Jaton, P.; Jawahery, A.; Jing, F.; John, M.; Johnson, D.; Jones, C. R.; Joram, C.; Jost, B.; Jurik, N.; Kaballo, M.; Kandybei, S.; Kanso, W.; Karacson, M.; Karbach, T. M.; Karodia, S.; Kelsey, M.; Kenyon, I. R.; Ketel, T.; Khanji, B.; Khurewathanakul, C.; Klaver, S.; Klimaszewski, K.; Kochebina, O.; Kolpin, M.; Komarov, I.; Koopman, R. F.; Koppenburg, P.; Korolev, M.; Kozlinskiy, A.; Kravchuk, L.; Kreplin, K.; Kreps, M.; Krocker, G.; Krokovny, P.; Kruse, F.; Kucewicz, W.; Kucharczyk, M.; Kudryavtsev, V.; Kurek, K.; Kvaratskheliya, T.; La Thi, V. N.; Lacarrere, D.; Lafferty, G.; Lai, A.; Lambert, D.; Lambert, R. W.; Lanfranchi, G.; Langenbruch, C.; Langhans, B.; Latham, T.; Lazzeroni, C.; Le Gac, R.; van Leerdam, J.; Lees, J.-P.; Lefèvre, R.; Leflat, A.; Lefrançois, J.; Leo, S.; Leroy, O.; Lesiak, T.; Leverington, B.; Li, Y.; Likhomanenko, T.; Liles, M.; Lindner, R.; Linn, C.; Lionetto, F.; Liu, B.; Lohn, S.; Longstaff, I.; Lopes, J. H.; Lopez-March, N.; Lowdon, P.; Lu, H.; Lucchesi, D.; Luo, H.; Lupato, A.; Luppi, E.; Lupton, O.; Machefert, F.; Machikhiliyan, I. V.; Maciuc, F.; Maev, O.; Malde, S.; Malinin, A.; Manca, G.; Mancinelli, G.; Maratas, J.; Marchand, J. F.; Marconi, U.; Marin Benito, C.; Marino, P.; Märki, R.; Marks, J.; Martellotti, G.; Martens, A.; Martín Sánchez, A.; Martinelli, M.; Martinez Santos, D.; Martinez Vidal, F.; Martins Tostes, D.; Massafferri, A.; Matev, R.; Mathe, Z.; Matteuzzi, C.; Mazurov, A.; McCann, M.; McCarthy, J.; McNab, A.; McNulty, R.; McSkelly, B.; Meadows, B.; Meier, F.; Meissner, M.; Merk, M.; Milanes, D. A.; Minard, M.-N.; Moggi, N.; Molina Rodriguez, J.; Monteil, S.; Morandin, M.; Morawski, P.; Mordà, A.; Morello, M. J.; Moron, J.; Morris, A.-B.; Mountain, R.; Muheim, F.; Müller, K.; Mussini, M.; Muster, B.; Naik, P.; Nakada, T.; Nandakumar, R.; Nasteva, I.; Needham, M.; Neri, N.; Neubert, S.; Neufeld, N.; Neuner, M.; Nguyen, A. D.; Nguyen, T. D.; Nguyen-Mau, C.; Nicol, M.; Niess, V.; Niet, R.; Nikitin, N.; Nikodem, T.; Novoselov, A.; O'Hanlon, D. P.; Oblakowska-Mucha, A.; Obraztsov, V.; Oggero, S.; Ogilvy, S.; Okhrimenko, O.; Oldeman, R.; Onderwater, G.; Orlandea, M.; Otalora Goicochea, J. M.; Owen, P.; Oyanguren, A.; Pal, B. K.; Palano, A.; Palombo, F.; Palutan, M.; Panman, J.; Papanestis, A.; Pappagallo, M.; Pappalardo, L. L.; Parkes, C.; Parkinson, C. J.; Passaleva, G.; Patel, G. D.; Patel, M.; Patrignani, C.; Pazos Alvarez, A.; Pearce, A.; Pellegrino, A.; Pepe Altarelli, M.; Perazzini, S.; Perez Trigo, E.; Perret, P.; Perrin-Terrin, M.; Pescatore, L.; Pesen, E.; Petridis, K.; Petrolini, A.; Picatoste Olloqui, E.; Pietrzyk, B.; Pilař, T.; Pinci, D.; Pistone, A.; Playfer, S.; Plo Casasus, M.; Polci, F.; Poluektov, A.; Polycarpo, E.; Popov, A.; Popov, D.; Popovici, B.; Potterat, C.; Price, E.; Prisciandaro, J.; Pritchard, A.; Prouve, C.; Pugatch, V.; Puig Navarro, A.; Punzi, G.; Qian, W.; Rachwal, B.; Rademacker, J. H.; Rakotomiaramanana, B.; Rama, M.; Rangel, M. S.; Raniuk, I.; Rauschmayr, N.; Raven, G.; Reichert, S.; Reid, M. M.; dos Reis, A. C.; Ricciardi, S.; Richards, S.; Rihl, M.; Rinnert, K.; Rives Molina, V.; Roa Romero, D. A.; Robbe, P.; Rodrigues, A. B.; Rodrigues, E.; Rodriguez Perez, P.; Roiser, S.; Romanovsky, V.; Romero Vidal, A.; Rotondo, M.; Rouvinet, J.; Ruf, T.; Ruiz, H.; Ruiz Valls, P.; Saborido Silva, J. J.; Sagidova, N.; Sail, P.; Saitta, B.; Salustino Guimaraes, V.; Sanchez Mayordomo, C.; Sanmartin Sedes, B.; Santacesaria, R.; Santamarina Rios, C.; Santovetti, E.; Sarti, A.; Satriano, C.; Satta, A.; Saunders, D. M.; Savrie, M.; Savrina, D.; Schiller, M.; Schindler, H.; Schlupp, M.; Schmelling, M.; Schmidt, B.; Schneider, O.; Schopper, A.; Schune, M.-H.; Schwemmer, R.; Sciascia, B.; Sciubba, A.; Seco, M.; Semennikov, A.; Sepp, I.; Serra, N.; Serrano, J.; Sestini, L.; Seyfert, P.; Shapkin, M.; Shapoval, I.; Shcheglov, Y.; Shears, T.; Shekhtman, L.; Shevchenko, V.; Shires, A.; Silva Coutinho, R.; Simi, G.; Sirendi, M.; Skidmore, N.; Skwarnicki, T.; Smith, N. A.; Smith, E.; Smith, E.; Smith, J.; Smith, M.; Snoek, H.; Sokoloff, M. D.; Soler, F. J. P.; Soomro, F.; Souza, D.; Souza De Paula, B.; Spaan, B.; Sparkes, A.; Spradlin, P.; Sridharan, S.; Stagni, F.; Stahl, M.; Stahl, S.; Steinkamp, O.; Stenyakin, O.; Stevenson, S.; Stoica, S.; Stone, S.; Storaci, B.; Stracka, S.; Straticiuc, M.; Straumann, U.; Stroili, R.; Subbiah, V. K.; Sun, L.; Sutcliffe, W.; Swientek, K.; Swientek, S.; Syropoulos, V.; Szczekowski, M.; Szczypka, P.; Szilard, D.; Szumlak, T.; T'Jampens, S.; Teklishyn, M.; Tellarini, G.; Teubert, F.; Thomas, C.; Thomas, E.; van Tilburg, J.; Tisserand, V.; Tobin, M.; Tolk, S.; Tomassetti, L.; Tonelli, D.; Topp-Joergensen, S.; Torr, N.; Tournefier, E.; Tourneur, S.; Tran, M. T.; Tresch, M.; Tsaregorodtsev, A.; Tsopelas, P.; Tuning, N.; Ubeda Garcia, M.; Ukleja, A.; Ustyuzhanin, A.; Uwer, U.; Vagnoni, V.; Valenti, G.; Vallier, A.; Vazquez Gomez, R.; Vazquez Regueiro, P.; Vázquez Sierra, C.; Vecchi, S.; Velthuis, J. J.; Veltri, M.; Veneziano, G.; Vesterinen, M.; Viaud, B.; Vieira, D.; Vieites Diaz, M.; Vilasis-Cardona, X.; Vollhardt, A.; Volyanskyy, D.; Voong, D.; Vorobyev, A.; Vorobyev, V.; Voß, C.; Voss, H.; de Vries, J. A.; Waldi, R.; Wallace, C.; Wallace, R.; Walsh, J.; Wandernoth, S.; Wang, J.; Ward, D. R.; Watson, N. K.; Websdale, D.; Whitehead, M.; Wicht, J.; Wiedner, D.; Wilkinson, G.; Williams, M. P.; Williams, M.; Wilson, F. F.; Wimberley, J.; Wishahi, J.; Wislicki, W.; Witek, M.; Wormser, G.; Wotton, S. A.; Wright, S.; Wu, S.; Wyllie, K.; Xie, Y.; Xing, Z.; Xu, Z.; Yang, Z.; Yuan, X.; Yushchenko, O.; Zangoli, M.; Zavertyaev, M.; Zhang, L.; Zhang, W. C.; Zhang, Y.; Zhelezov, A.; Zhokhov, A.; Zhong, L.; Zvyagin, A.; LHCb Collaboration

    2014-10-01

    A baryonic decay of the Bc+ meson, Bc+→J/ψpp ¯π+, is observed for the first time, with a significance of 7.3 standard deviations, in pp collision data collected with the LHCb detector and corresponding to an integrated luminosity of 3.0 fb-1 taken at center-of-mass energies of 7 and 8 TeV. With the Bc+→J/ψπ+ decay as the normalization channel, the ratio of branching fractions is measured to be B(Bc+→J/ψpp ¯π+)/B(Bc+→J/ψπ+)=0.143-0.034+0.039(stat)±0.013(syst). The mass of the Bc+ meson is determined as M(Bc+)=6274.0±1.8(stat)±0.4(syst) MeV/c2, using the Bc+→J/ψpp ¯π+ channel.

  8. Aspects That Concern Assessing Lower Secondary School Students at the Physics National Contest Exemplification for the 7th Grade

    ERIC Educational Resources Information Center

    Florian, Gabriel

    2014-01-01

    In the present article, we aim at analysing the results obtained by the 7th grade students who participated in the 50th edition of the Physics National Contest, which took place in Cluj-Napoca between the 6th and the 11th of April, 2014. Why have we chosen the 7th grade? One of the reasons is represented by the good results obtained by the…

  9. Charge It! Translating Electric Vehicle Research Results to Engage 7th and 8th Grade Girls

    NASA Astrophysics Data System (ADS)

    Egbue, Ona; Long, Suzanna; Ng, Ean-Harn

    2015-10-01

    Despite attempts to generate interest in science and technology careers, US students continue to show reduced interest in science, technology, engineering and mathematics (STEM) majors at the collegiate level. If girls are not engaged in STEM learning by the middle school level, studies show that they are even less likely to choose a science- or engineering-related major. This article presents results from a workshop for 7th and 8th grade girls designed to promote knowledge building in the area of sustainability and alternative energy use in transportation and to stimulate greater interest in STEM subjects. The workshop based on research conducted at University X focused on basic concepts of electric vehicles and electric vehicles' batteries. Tests were conducted to evaluate the students' knowledge and perceptions of electric vehicles and to determine the impact of the workshop. Early exposure to meaningful engineering experiences for these young girls may boost interest and the eventual pursuit of engineering and technology education paths.

  10. White Macael marble: a key element in the architectonic heritage of Andalusia for over 25 centuries

    NASA Astrophysics Data System (ADS)

    Navarro, Rafael; Sol Cruz, Ana; Arriaga, Lourdes; Baltuille, José Manuel

    2013-04-01

    Marble from Macael (Andalusia) is one of the most important natural stones in the architectonic heritage of Andalusia; in particular the variety commercially known as "White Macael". This natural stone has been used outdoors as well as indoors for decorative, ornamental or structural purposes. During the 7th century (B.C.) the Phoenicians began to systematically extract these quarries to be used in their more social important elements such as sarcophagus. During the Roman period this rock had a greater importance in construction; we find columns, pavements, tombstones… in many historical buildings such as the Roman amphitheatre in Mérida (1st century B.C.) and the city of Itálica in Seville (3rd century B.C.). But it is during the Muslim period when marble from Macael is more widely used: the Mosque of Córdoba (8th century), the Lions Court in the Alhambra palace, the Alcazaba in Almería, the Medina-Azahara palace in Córdoba (10th century). Other important buildings using the white marble are: Carlos V palace or the Royal Chapel in Granada (15th century), the Almería cathedral or El Escorial monastery in Madrid (16th century), San Telmo palace in Seville (17th century) or The Royal Palace in Madrid (18th century). Uncountable number of buildings, both historical and contemporary, show different elements made of this marble. From a geological point of view, the quarries are located in the upper part of the Nevado-Filábride Complex, the lowest nappe of the Internal Zones of the Betic Chains. Under the "White Macael" name is also possible to include another commercial denominations such "White Macael Río" or "White Macael Río Veteado". It is a clear white coloured, calcitic marble (up than 97% calcite), with average grain size between 0,16 y 3,2 mm in a mosaic texture with a very homogenous aspect. Regarding the main physical and mechanical properties, this rock has an open porosity value between 0,1-0,6%, bulk density 2,50-2,75 g/cm3, water absorption at

  11. Earth's Variable Rotation from 750BC to present

    NASA Astrophysics Data System (ADS)

    Morrison, Leslie Valentine; Hohenkerk, Catherine; Stephenson, F. Richard

    2015-08-01

    Ancient Babylonian clay tablets buried for centuries beneath the sands of the desert are part of an extensive historical archive that contains vital information about the Earth's rotation from 750BC to the present. These historical observations of solar and lunar eclipses and occultations of stars are re-analysed to determine the error of the Earth's rotational clock, usually designated by ΔT. The diagrams display the individual results for ΔT, together with the best-fitting curve through these data.

  12. The result of Venus Orbit Insertion of Akatsuki on December 7th, 2015

    NASA Astrophysics Data System (ADS)

    Sugiyama, K. I.; Nakamura, M.; Imamura, T.; Ishii, N.; Abe, T.; Kawakatsu, Y.; Hirose, C.; Satoh, T.; Suzuki, M.; Ueno, M.; Yamazaki, A.; Iwagami, N.; Watanabe, S.; Taguchi, M.; Fukuhara, T.; Takahashi, Y.; Yamada, M.; Imai, M.; Ohtsuki, S.; Uemizu, K.; Hashimoto, G. L.; Takagi, M.; Matsuda, Y.; Ogohara, K.; Sato, N.; Kasaba, Y.; Kouyama, T.; Hirata, N.; Nakamura, R.; Yamamoto, Y.; Horinouchi, T.; Yamamoto, M.; Hayashi, Y. Y.; Nakatsuka, J.; Kashimura, H.; Sakanoi, T.; Ando, H.; Murakami, S. Y.; Sato, T.; Takagi, S.; Nakajima, K.; Peralta, J.; Lee, Y. J.

    2015-12-01

    Japan launched Venus Climate Orbiter 'Akatsuki' (JAXA's mission code name: PLANET-C) to observe the dynamics of the Venus atmosphere globally and clarify the mechanism of the atmospheric circulation. The launch was on May 21st , 2010 from the Tanegashima Space Center. The cruise to Venus was smooth, however, the first Venus Orbit Insertion (VOI) trial on December 7th, 2010 tuned out to be a failure. Later Akatsuki has been orbiting the sun. Fortunately we keep the spacecraft in a healthy condition and surprisingly we have found another chance to let this spacecraft to meet Venus in 2015. Next VOI trial will be done on December 7th, 2015 and we report the result of this operation at this AGU meeting. This mission is planed to answer the question described below. The radius of the Earth and Venus are almost the same. In addition the radiation from the sun is also almost the same. The climates of these planets, however, are much different. For example, the strong zonal wind is observed on Venus with the period of 4 days, where Venus rotates westward with the period of 243 days. The wind speed is about 100 m s-1. This is called super rotation. We will investigate from data from Akatsuki what attributes to the difference of the climates between Earth and Venus. AKATSUKI was designed for remote sensing from an equatorial, elliptical orbit to tract the atmospheric motion at different altitudes using 5 cameras (3xIR, UV, Visible) and by the radio occultation technique. The first VOI has failed due to a malfunction of the propulsion system. The check valve between the helium tank and the fuel tank was blocked by an unexpected salt formation during the cruising from the Earth to Venus. As a result the main engine (orbital maneuvering engine, OME) became oxidizer-rich and fuel-poor condition, which led to an abnormal combustion in the engine with high temperature, and finally the engine was broken. We decide to use RCS thrusters for Trajectory Control Maneuvers' (TCMs) and

  13. Meeting report from the 7th International Melanoma Congress, Sydney, November, 2010.

    PubMed

    Hersey, P; Smalley, K S M; Weeraratna, A; Bosenberg, M; Zhang, X D; Haass, N K; Paton, E; Mann, G; Scolyer, R A; Tüting, T

    2011-02-01

    The 2010 7th International Melanoma Congress sponsored by the Society for Melanoma Research and held in Sydney, Australia, was held together with the International Melanoma and Skin Cancer Centers group and the International Melanoma Pathology Study Group. As a consequence, there were over 900 registrants that included a wide range of clinicians (surgeons, medical oncologists, dermatologists) specialising in the management of melanoma as well as scientists and students carrying out laboratory-based research in melanoma. There was a general consensus that this grouping of clinicians, pathologists and scientists was mutually advantageous and plans are afoot to continue this grouping in future meetings. The meeting was dominated by the advances being made in treatment of melanoma with selective BRAF inhibitors but interest in epithelial mesenchymal transition and phenotypic changes in melanoma was apparent in many of the talks. The authors have attempted to capture many of the new developments in melanoma research but apologize to those speakers and poster presenters who had equally important findings not captured in these summaries. PMID:21232023

  14. PREFACE: Proceedings of the 7th International LISA Symposium, Barcelona, Spain, 16-20 June 2008

    NASA Astrophysics Data System (ADS)

    Lobo, Alberto; Sopuerta, Carlos F.

    2009-07-01

    In June 2006 the LISA International Science Team (LIST) accepted the bid presented by the Institut d'Estudis Espacials de Catalunya (IEEC) to host the 7th International LISA Symposium. This was during its 11th meeting at the University of Maryland, just before the 6th edition of the Symposium started in NASA's Goddard Space Flight Center. The 7th International LISA Symposium took place at the city of Barcelona, Spain, from 16-20 June 2008, in the premises of CosmoCaixa, a modern Science Museum located in the hills near Tibidabo. Almost 240 delegates registered for the event, a record breaking figure compared to previous editions of the Symposium. Many of the most renowned world experts in LISA, Gravitational Wave Science, and Astronomy, as well as Engineers, attended LISA 7 and produced state-of-the-art presentations, while everybody benefited from the opportunity to have live discussions during the week in a friendly environment. The programme included 31 invited plenary lectures in the mornings, and 8 parallel sessions in the afternoons. These were classified into 7 major areas of research: LISA Technology, LISA PathFinder, LISA PathFinder Data Analysis, LISA Data Analysis, Gravitational Wave sources, Cosmology and Fundamental Physics with LISA and Other Gravitational Wave Detectors. 138 abstracts for communications were received, of which a selection was made by the session convenors which would fit time constraints. Up to 63 posters completed the scientific programme. More details on the programme, including some of the talks, can be found at the Symposium website: http://www.ice.cat/research/LISA_Symposium. There was however a remarkable add-on: Professor Clifford Will delivered a startling presentation to the general public, who completely filled the Auditori—the main Conference Room, 320 seats—and were invited to ask questions to the speaker who had boldly guided them through the daunting world of Black Holes, Waves of Gravity, and other Warped Ideas of

  15. Boston Edison and LG&E win 7th annual substation design contest

    SciTech Connect

    Beaty, W.

    1996-07-01

    Boston`s Edison`s Network Station 53 won First Place in the engineering/operations category of Electric Light & Power`s 7th annual substation design contest. Station 53 also took Second Place in the aesthetic design category. Boston Edison is no stranger to the contest, having won top honors in the aesthetic category in the very first contest in 1990. That same year, Boston took Second Place in engineering/operations design and Third Place in aesthetic design. Station 53 occupies a 12,074-square-foot site in the heart of the Boston financial district. It replaces an existing station where the land was required for Boston`s Central Artery project. Great care was taken to ensure that Station 53 would blend into the cityscape and be pleasing to the eye. The architectural treatment was designed by the Boston Anderson-Nichols & Company Inc., in cooperation with the Boston Redevelopment Authority. The latest in engineering technology was utilized to guarantee reliability, maintain the highest service quality and provide capacity for future load growth in the downtown area. Station 53 is supplied by two underground 115-kV pipe-type transmission cables. Unattended and remotely operated, Station 53 has the capability of sectionalizing the 115-kV power supply by remote control to isolate the faulted sections.

  16. BC Transfer System: New Members Policy

    ERIC Educational Resources Information Center

    British Columbia Council on Admissions and Transfer, 2009

    2009-01-01

    The mandate of the British Columbia Council on Admissions and Transfer (BCCAT) includes the responsibility to manage and coordinate the British Columbia (BC) Transfer System. Upon its inception in 1989, the Council inherited a Transfer System that included all BC public institutions, Yukon College, and three private institutions. Since then, new…

  17. How 7th Graders Are Using Asynchronous Resources in an Online Science Course: A Mixed Methods Study

    ERIC Educational Resources Information Center

    Schafer-Mayse, Diane L.

    2013-01-01

    In this study 7th grade students were observed completing a series of lessons in an online science course to explore their thinking and strategies for using curriculum resources for learning, to explore their thinking and strategies for self-assessing their readiness for lesson assessment, and to explore the relationship between resource use and…

  18. Publications of Proceedings for the RF 2005 7th Workshop on High Energy Density and High Power RF

    SciTech Connect

    Luhmann, Jr, N C

    2006-01-01

    The University of California, Davis hosted the High Energy Density and High Power RF 7th Workshop on High Energy Density and High Power RF in Kalamata, Greece, 13-17 June, 2005. The Proceedings cost was supported by these funds from the U.S. Department of Energy. The Proceedings was published through the American Institute of Physics.

  19. Impacts of a Discussion-Based Academic Language Program on Classroom Interactions in 4th through 7th Grades

    ERIC Educational Resources Information Center

    LaRusso, Maria; Jones, Stephanie M.; Kim, Ha Yeon; Kim, James; Donovan, Suzanne; Snow, Catherine

    2016-01-01

    This paper presents an exploratory analysis of treatment-control differences in the quality of classroom interactions in 4th through 7th grade urban classrooms. Word Generation (WG) is a research-based academic language program for middle school students designed to teach novel vocabulary and literacy through language arts, math, science, and…

  20. Primary School English Teachers' Perceptions of the English Language Curriculum of 6th, 7th and 8th Grades

    ERIC Educational Resources Information Center

    Ersen Yanik, Asli

    2008-01-01

    This study aims to investigate how the teachers who have different background characteristics perceive the goals and content of the English language curriculum implemented at the 6th, 7th and 8th grades of public primary schools. The study was conducted during the 2004-2005 school year with 368 English teachers selected from the seven regions of…

  1. The Effect of Learning Integers Using Cartoons on 7th Grade Students' Attitude to Mathematics

    ERIC Educational Resources Information Center

    Sengül, Sare; Dereli, Mehtap

    2013-01-01

    The purpose of this research is to investigate the effect on students' attitudes toward mathematics when cartoons are used in teaching integers. The research was designed in the form of a pre-test and post-test with a quasi experimental control group. The research participant group was composed of sixty-one (61) 7th grade students attending…

  2. Cultivating Environmental Virtue among 7th and 8th Graders in an Expeditionary Learning Outward Bound School

    ERIC Educational Resources Information Center

    Martin, Bruce; Bright, Alan; Cafaro, Philip; Mittelstaedt, Robin; Bruyere, Brett

    2008-01-01

    This study attempted to assess the development of environmental virtue in 7th and 8th grade students in an Expeditionary Learning Outward Bound school. The purpose of this study was twofold. First, the researchers were interested in introducing a virtue ethics perspective into their teaching of environmental ethics. Second, the researchers were…

  3. PREFACE: 7th International Conference on Applications of Physics in Financial Analysis

    NASA Astrophysics Data System (ADS)

    Takayasu, M.; Watanabe, T.; Ikeda, Y.; Takayasu, H.

    2010-04-01

    This volume contains contributed papers from the 7th international conference on 'Applications of Physics in Financial Analysis (APFA)' held at Tokyo on 1-5 March 2009. The conference was organized jointly by Tokyo Institute of Technology and Hitotsubashi University with support from the Research Institute of Economy, Trade, and Industry (RIETI), Physical Society of Japan, Japanese Economic Association, Information Processing Society of Japan, Japanese Society for Artificial Intelligence, and Japan Association for Evolutionary Economics. The first APFA conference (APFA1) was held in 1999 at Dublin, followed by APFA2 at Liege in 2000, APFA3 at London in 2001, APFA4 at Warsaw in 2003, APFA5 at Torino in 2006, and APFA6 at Lisbon in 2007. The 7th APFA conference, which is the first meeting held outside Europe, was attended by 223 researchers in physics and economics from 23 countries world-wide. In keeping with past APFA conferences, we paid special attention to issues in financial markets, which turned out to be very timely. The conference was held in March 2009, in the middle of the global financial crisis that originally started in the US and spread quickly to every corner of the world. The topic of the conference is 'New Approaches to the Analysis of Large Scale Business and Economic data'. The rapid development of information and communication technology has enabled financial/non-financial firms to keep detailed records of their business activities in the form of, for example, tick-by-tick data in financial markets, point-of-sale (POS) data on individual household's purchasing activity, and interfirm network data describing relationships among firms in terms of suppliers/customers transactions and ownerships. This growth in the scope and amount of business data available to researchers has led to a far-reaching expansion in research possibilities. Researchers not only in social sciences but also in physics, mathematics, and information sciences have recently

  4. PREFACE: 7th International Conference on Modern Practice in Stress and Vibration Analysis

    NASA Astrophysics Data System (ADS)

    Barton, J.

    2009-07-01

    The proceedings contain the papers presented at the 7th International Conference on Modern Practice in Stress and Vibration Analysis. The collection of papers represents the range of activities that are carried out to understand the functionality of engineering systems and structures through stress/strain based evaluation and dynamic response. The scope is broad and covers theoretical studies, modelling and experimental evaluations. Many of the papers cover integration techniques and approaches to better understanding of system performance and failure. All of the papers have been peer reviewed by at least two experts and represent the state of the art of research in this area. The conference is the seventh in the series, following on from previous conferences in Bath, Glasgow, Nottingham, Dublin, Sheffield and Liverpool. Although based in the British Isles the conference has a truly international flavour with offerings from 22 countries. The conference is organised by the Institute of Physics Applied Mechanics Group (formerly the Stress and Vibration Group). It incorporates activities associated with the British Society for Strain Measurement including the Measurements Lecture, the EMex Exhibition and the Young Stress Analyst Competition. The organising committee is grateful for the support of all of the authors, the scientific committee and keynote speakers who played a significant role in the review process, to John Edwards who was instrumental in managing the paper review and submission process, Dawn Stewart and Claire Garland of the Institute of Physics for organising the conference, social programme and registration and Biana Gale of the British Society for Strain Measurement for organising the Exhibition. The organising committee is also grateful to the sponsors of the conference for their kind support and to the co-sponsors for distributing information on the conference. Professor Janice Barton Professor of Experimental Mechanics University of Southampton

  5. PREFACE: 7th International Conference on Modern Practice in Stress and Vibration Analysis

    NASA Astrophysics Data System (ADS)

    Dulieu-Barton, J. M.

    2009-07-01

    The proceedings contain the papers presented at the 7th International Conference on Modern Practice in Stress and Vibration Analysis. The collection of papers represents the range of activities that are carried out to understand the functionality of engineering systems and structures through stress/strain based evaluation and dynamic response. The scope is broad and covers theoretical studies, modelling and experimental evaluations. Many of the papers cover integration techniques and approaches to better understanding of system performance and failure. All of the papers have been peer reviewed by at least two experts and represent the state of the art of research in this area. The conference is the seventh in the series, following on from previous conferences in Bath, Glasgow, Nottingham, Dublin, Sheffield and Liverpool. Although based in the British Isles the conference has a truly international flavour with offerings from 22 countries. The conference is organised by the Institute of Physics Applied Mechanics Group (formerly the Stress and Vibration Group). It incorporates activities associated with the British Society for Strain Measurement including the Measurements Lecture, the EMex Exhibition and the Young Stress Analyst Competition. The organising committee is grateful for the support of all of the authors, the scientific committee and keynote speakers who played a significant role in the review process, to John Edwards who was instrumental in managing the paper review and submission process, Dawn Stewart and Claire Garland of the Institute of Physics for organising the conference, social programme and registration and Biana Gale of the British Society for Strain Measurement for organising the Exhibition. The organising committee is also grateful to the sponsors of the conference for their kind support and to the co-sponsors for distributing information on the conference. Professor Janice M Dulieu-Barton Professor of Experimental Mechanics University of

  6. Endoscopic ultrasonography guided biliary drainage: Summary of consortium meeting, May 7th, 2011, Chicago

    PubMed Central

    Kahaleh, Michel; Artifon, Everson LA; Perez-Miranda, Manuel; Gupta, Kapil; Itoi, Takao; Binmoeller, Kenneth F; Giovannini, Marc

    2013-01-01

    Endoscopic retrograde cholangiopancreatography (ERCP) has become the preferred procedure for biliary or pancreatic drainage in various pancreatico-biliary disorders. With a success rate of more than 90%, ERCP may not achieve biliary or pancreatic drainage in cases with altered anatomy or with tumors obstructing access to the duodenum. In the past those failures were typically managed exclusively by percutaneous approaches by interventional radiologists or surgical intervention. The morbidity associated was significant especially in those patients with advanced malignancy, seeking minimally invasive interventions and improved quality of life. With the advent of biliary drainage via endoscopic ultrasound (EUS) guidance, EUS guided biliary drainage has been used more frequently within the last decade in different countries. As with any novel advanced endoscopic procedure that encompasses various approaches, advanced endoscopists all over the world have innovated and adopted diverse EUS guided biliary and pancreatic drainage techniques. This diversity has resulted in variations and improvements in EUS Guided biliary and pancreatic drainage; and over the years has led to an extensive nomenclature. The diversity of techniques, nomenclature and recent progress in our intrumentation has led to a dedicated meeting on May 7th, 2011 during Digestive Disease Week 2011. More than 40 advanced endoscopists from United States, Brazil, Mexico, Venezuela, Colombia, Italy, France, Austria, Germany, Spain, Japan, China, South Korea and India attended this pivotal meeting. The meeting covered improved EUS guided biliary access and drainage procedures, terminology, nomenclature, training and credentialing; as well as emerging devices for EUS guided biliary drainage. This paper summarizes the meeting’s agenda and the conclusions generated by the creation of this consortium group. PMID:23538784

  7. 7th International Workshop on Microbeam Probes of Cellular Radiation Response

    SciTech Connect

    Brenner, David J.

    2009-07-21

    The extended abstracts that follow present a summary of the Proceedings of the 7th International Workshop: Microbeam Probes of Cellular Radiation Response, held at Columbia University’s Kellogg Center in New York City on March 15–17, 2006. These International Workshops on Microbeam Probes of Cellular Radiation Response have been held regularly since 1993 (1–5). Since the first workshop, there has been a rapid growth (see Fig. 1) in the number of centers developing microbeams for radiobiological research, and worldwide there are currently about 30 microbeams in operation or under development. Single-cell/single-particle microbeam systems can deliver beams of different ionizing radiations with a spatial resolution of a few micrometers down to a few tenths of a micrometer. Microbeams can be used to addressquestions relating to the effects of low doses of radiation (a single radiation track traversing a cell or group of cells), to probe subcellular targets (e.g. nucleus or cytoplasm), and to address questions regarding the propagation of information about DNA damage (for example, the radiation-induced bystander effect). Much of the recent research using microbeams has been to study low-dose effects and ‘‘non-targeted’’ responses such as bystander effects, genomic instability and adaptive responses. This Workshop provided a forum to assess the current state of microbeam technology and current biological applications and to discuss future directions for development, both technological and biological. Over 100 participants reviewed the current state of microbeam research worldwide and reported on new technological developments in the fields of both physics and biology.

  8. PREFACE: 7th International Conference on Cooling & Heating Technologies (ICCHT 2014)

    NASA Astrophysics Data System (ADS)

    2015-09-01

    The Kyoto protocol has initiated a pledge from almost all developing and developed countries to be committed to reducing CO2 emissions. Development of new renewable energy technologies are also of interest in this conference. Greenhouse gases have contributed to global warming and other man-made disasters. Cooling and Heating communities also have responsibilities towards the commitment of reducing the greenhouse gas emissions. In addition, depleting natural resources also act as a threat to the Cooling and Heating industries, causing them to develop highly efficient equipment and innovative technologies. The 1st International Conference on Cooling & Heating Technologies was held in Hanoi Vietnam (Jan. 2005). Whereas the 2nd, 3rd, 4th and 5th ICCHT conferences were held in Dalian, China (Jul. 2006), Tokyo, Japan (Jul. 2007), Jinhae, Korea (Oct. 2008) and Bandung, Indonesia (Dec. 2010) respectively. The 6th International Conference on Cooling & Heating Technologies (ICCTH2012) was held in Xi'an in China on November 9-12, 2012. It is our pleasure to welcome you to the 7th International Conference on Cooling & Heating Technologies (ICCTH2014) on 4th - 6th November 2014 at the Grand Dorsett Subang Hotel, Subang Jaya, Selangor Darul Ehsan, Malaysia The Theme of the Conference is ''Sustainability and Innovation in Heating & Cooling Technologies''. The sub-themes are:- • CO2 Reduction and Low Carbon Technologies • HVAC System and Natural Ventilation • Energy & Alternative Energy • Computational Fluid Dynamics • Low Temperature & Refrigeration Engineering In conjunction with the Conference, an Exhibition will be organized as an integral part of the Conference. Project experiences, product solutions, new applications and state-of-the art information will be highlighted.

  9. Cytochrome bc1 complexes of microorganisms.

    PubMed Central

    Trumpower, B L

    1990-01-01

    The cytochrome bc1 complex is the most widely occurring electron transfer complex capable of energy transduction. Cytochrome bc1 complexes are found in the plasma membranes of phylogenetically diverse photosynthetic and respiring bacteria, and in the inner mitochondrial membrane of all eucaryotic cells. In all of these species the bc1 complex transfers electrons from a low-potential quinol to a higher-potential c-type cytochrome and links this electron transfer to proton translocation. Most bacteria also possess alternative pathways of quinol oxidation capable of circumventing the bc1 complex, but these pathways generally lack the energy-transducing, protontranslocating activity of the bc1 complex. All cytochrome bc1 complexes contain three electron transfer proteins which contain four redox prosthetic groups. These are cytochrome b, which contains two b heme groups that differ in their optical and thermodynamic properties; cytochrome c1, which contains a covalently bound c-type heme; and a 2Fe-2S iron-sulfur protein. The mechanism which links proton translocation to electron transfer through these proteins is the proton motive Q cycle, and this mechanism appears to be universal to all bc1 complexes. Experimentation is currently focused on understanding selected structure-function relationships prerequisite for these redox proteins to participate in the Q-cycle mechanism. The cytochrome bc1 complexes of mitochondria differ from those of bacteria, in that the former contain six to eight supernumerary polypeptides, in addition to the three redox proteins common to bacteria and mitochondria. These extra polypeptides are encoded in the nucleus and do not contain redox prosthetic groups. The functions of the supernumerary polypeptides of the mitochondrial bc1 complexes are generally not known and are being actively explored by genetically manipulating these proteins in Saccharomyces cerevisiae. Images PMID:2163487

  10. Selected papers from the 7th International Conference on Microtechnologies in Medicine and Biology (MMB 2013)

    NASA Astrophysics Data System (ADS)

    Meng, Ellis; Takayama, Shuichi

    2014-03-01

    In this special section of Journal of Micromechanics and Microengineering are a collection of the best microengineering papers presented at the 7th International Conference on Microtechnologies in Medicine and Biology (MMB 2013) which took place in the seaside town of Marina del Rey, California, USA on 10-12 April, 2013. During the 3-day conference, participants enjoyed talks from 6 invited keynote speakers and 125 flash oral/poster presentations. The MMB conference is a biennial meeting with the primary purpose of fostering interactions between biologists and medical researchers, clinicians, chemists, physicists and engineers to enhance and strengthen the potential microtechnologies that will revolutionize the fields of medicine and biological sciences. The conference possesses a unique format where all poster presenters provide a brief 60 s oral presentation highlighting their research. This format was devised to provide training and exposure for young researchers, especially PhD students and postdocs, in the field and stimulate interdisciplinary exchanges. Therefore, MMB provides an intimate intellectual venue the facilitate discussions and collaborations to advance new research tools and technologies for medicine and biological sciences. The MMB conference series was co-founded by Professor David Beebe (University of Wisconsin—Madison) and Professor André Dittmar (University of Lyon) and was the first international meeting to provide a forum focusing on emerging applications of microtechnologies to unmet needs in medicine and biology. The series was held for the first time in 2000, in Lyon, France and followed by Madison, USA (2002), Oahu Island in Hawaii, USA (2005), Okinawa, Japan (2006), Québec City, Canada (2009), Lucerne, Switzerland (2011), and Marina del Rey, USA (2013). The next conference will be held in Seoul, Korea in 2015. This collection of articles highlights recent progress in microtechnologies with medical and biological applications. We are

  11. FOREWORD: 7th Symposium on Vacuum-based Science and Technology (SVBST2013)

    NASA Astrophysics Data System (ADS)

    Gulbiński, W.

    2014-11-01

    These are the proceedings of the 7th Symposium on Vacuum based Science and Technology organized in Kołobrzeg (PL) on November 19-21, 2013 by the Institute of Technology and Education, Koszalin University of Technology and the Clausius Tower Society under auspices of the Polish Vacuum Society (PTP) and the German Vacuum Society (DVG) and in collaboration with the BalticNet PlasmaTec and the Society of Vacuum Coaters (SVC). It was accompanied by the 12-th Annual Meeting of the German Vacuum Society. The mission of the Symposium is to provide a forum for presentation and exchange of expertise and research results in the field of vacuum and plasma science. After already six successful meetings organized alternately in Poland and Germany our goal is to continue and foster cooperation within the vacuum and plasma science community. This year, the Rudolf-Jaeckel Prize, awarded by the DVG for outstanding achievements in the field of vacuum based sciences, was presented to Dr Ute Bergner, president of the VACOM Vakuum Komponenten & Messtechnik GmbH and a member of our community. The full-day course organized in the framework of the Educational Program by the Society of Vacuum Coaters (SVC) and entitled: An Introduction to Physical Vapor Deposition (PVD) Processes was held on November 18, 2013 as a satellite event of the Symposium. The instructor was Prof. Ismat Shah from Delaware University (US). The Clausius Session, already traditionally organized during the Symposium was addressed this year to young generation. We invited our young colleagues to attend a series of educational lectures reporting on achievements in graphene science, scanning probe microscopy and plasma science. Lectures were given by: Prof. Jacek Baranowski from the Institute of Electronic Materials Technology in Warsaw, Prof. Teodor Gotszalk from the Wroclaw University of Technology and Prof. Holger Kersten from the Christian Albrechts University in Kiel. The Symposium was accompanied by an industry

  12. Proceedings of the Seventh International Conference on Educational Data Mining (EDM) (7th, London, United Kingdom, July 4-7, 2014)

    ERIC Educational Resources Information Center

    Stamper, John, Ed.; Pardos, Zachary, Ed.; Mavrikis, Manolis, Ed.; McLaren, Bruce M., Ed.

    2014-01-01

    The 7th International Conference on Education Data Mining held on July 4th-7th, 2014, at the Institute of Education, London, UK is the leading international forum for high-quality research that mines large data sets in order to answer educational research questions that shed light on the learning process. These data sets may come from the traces…

  13. 7th Annual Symposium on Self-Monitoring of Blood Glucose (SMBG), May 8–10, 2014, Helsinki, Finland

    PubMed Central

    Mlinac, Anita; Hinzmann, Rolf

    2014-01-01

    Abstract International experts in the fields of diabetes, diabetes technology, endocrinology, mobile health, sport science, and regulatory issues gathered for the 7th Annual Symposium on Self-Monitoring of Blood Glucose (SMBG). The aim of this meeting was to facilitate new collaborations and research projects to improve the lives of people with diabetes. The 2014 meeting comprised a comprehensive scientific program, parallel interactive workshops, and two keynote lectures. PMID:25211215

  14. Observation of the decay Bc+/--->J/psipi+/- and measurement of the Bc+/- mass.

    PubMed

    Aaltonen, T; Adelman, J; Akimoto, T; Albrow, M G; Alvarez González, B; Amerio, S; Amidei, D; Anastassov, A; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Apresyan, A; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Aurisano, A; Azfar, F; Azzi-Bacchetta, P; Azzurri, P; Bacchetta, N; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Baroiant, S; Bartsch, V; Bauer, G; Beauchemin, P-H; Bedeschi, F; Bednar, P; Behari, S; Bellettini, G; Bellinger, J; Belloni, A; Benjamin, D; Beretvas, A; Beringer, J; Berry, T; Bhatti, A; Binkley, M; Bisello, D; Bizjak, I; Blair, R E; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bolla, G; Bolshov, A; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Bridgeman, A; Brigliadori, L; Bromberg, C; Brubaker, E; Budagov, J; Budd, H S; Budd, S; Burkett, K; Busetto, G; Bussey, P; Buzatu, A; Byrum, K L; Cabrera, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carlsmith, D; Carosi, R; Carrillo, S; Carron, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, K; Chokheli, D; Chou, J P; Choudalakis, G; Chuang, S H; Chung, K; Chung, W H; Chung, Y S; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Compostella, G; Convery, M E; Conway, J; Cooper, B; Copic, K; Cordelli, M; Cortiana, G; Crescioli, F; Cuenca Almenar, C; Cuevas, J; Culbertson, R; Cully, J C; Dagenhart, D; Datta, M; Davies, T; de Barbaro, P; De Cecco, S; Deisher, A; De Lentdecker, G; De Lorenzo, G; Dell'Orso, M; Demortier, L; Deng, J; Deninno, M; De Pedis, D; Derwent, P F; Di Giovanni, G P; Dionisi, C; Di Ruzza, B; Dittmann, J R; D'Onofrio, M; Donati, S; Dong, P; Donini, J; Dorigo, T; Dube, S; Efron, J; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, W T; Feild, R G; Feindt, M; Fernandez, J P; Ferrazza, C; Field, R; Flanagan, G; Forrest, R; Forrester, S; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; Garberson, F; Garcia, J E; Garfinkel, A F; Genser, K; Gerberich, H; Gerdes, D; Giagu, S; Giakoumopolou, V; Giannetti, P; Gibson, K; Gimmell, J L; Ginsburg, C M; Giokaris, N; Giordani, M; Giromini, P; Giunta, M; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Golossanov, A; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gresele, A; Grinstein, S; Grosso-Pilcher, C; Grundler, U; Guimaraes da Costa, J; Gunay-Unalan, Z; Haber, C; Hahn, K; Hahn, S R; Halkiadakis, E; Hamilton, A; Han, B-Y; Han, J Y; Handler, R; Happacher, F; Hara, K; Hare, D; Hare, M; Harper, S; Harr, R F; Harris, R M; Hartz, M; Hatakeyama, K; Hauser, J; Hays, C; Heck, M; Heijboer, A; Heinemann, B; Heinrich, J; Henderson, C; Herndon, M; Heuser, J; Hewamanage, S; Hidas, D; Hill, C S; Hirschbuehl, D; Hocker, A; Hou, S; Houlden, M; Hsu, S-C; Huffman, B T; Hughes, R E; Husemann, U; Huston, J; Incandela, J; Introzzi, G; Iori, M; Ivanov, A; Iyutin, B; James, E; Jayatilaka, B; Jeans, D; Jeon, E J; Jindariani, S; Johnson, W; Jones, M; Joo, K K; Jun, S Y; Jung, J E; Junk, T R; Kamon, T; Kar, D; Karchin, P E; Kato, Y; Kephart, R; Kerzel, U; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kimura, N; Kirsch, L; Klimenko, S; Klute, M; Knuteson, B; Ko, B R; Koay, S A; Kondo, K; Kong, D J; Konigsberg, J; Korytov, A; Kotwal, A V; Kraus, J; Kreps, M; Kroll, J; Krumnack, N; Kruse, M; Krutelyov, V; Kubo, T; Kuhlmann, S E; Kuhr, T; Kulkarni, N P; Kusakabe, Y; Kwang, S; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; Lecompte, T; Lee, J; Lee, J; Lee, Y J; Lee, S W; Lefèvre, R; Leonardo, N; Leone, S; Levy, S; Lewis, J D; Lin, C; Lin, C S; Linacre, J; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, T; Lockyer, N S; Loginov, A; Loreti, M; Lovas, L; Lu, R-S; Lucchesi, D; Lueck, J; Luci, C; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; Lytken, E; Mack, P; Macqueen, D; Madrak, R; Maeshima, K; Makhoul, K; Maki, T; Maksimovic, P; Malde, S; Malik, S; Manca, G; Manousakis, A; Margaroli, F; Marino, C; Marino, C P; Martin, A; Martin, M; Martin, V; Martínez, M; Martínez-Ballarín, R; Maruyama, T; Mastrandrea, P; Masubuchi, T; Mattson, M E; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtala, P; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; Miao, T; Miladinovic, N; Miles, J; Miller, R; Mills, C; Milnik, M; Mitra, A; Mitselmakher, G; Miyake, H; Moed, S; Moggi, N; Moon, C S; Moore, R; Morello, M; Movilla Fernandez, P; Mülmenstädt, J; Mukherjee, A; Muller, Th; Mumford, R; Murat, P; Mussini, M; Nachtman, J; Nagai, Y; Nagano, A; Naganoma, J; Nakamura, K; Nakano, I; Napier, A; Necula, V; Neu, C; Neubauer, M S; Nielsen, J; Nodulman, L; Norman, M; Norniella, O; Nurse, E; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Oldeman, R; Orava, R; Osterberg, K; Pagan Griso, S; Pagliarone, C; Palencia, E; Papadimitriou, V; Papaikonomou, A; Paramonov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Piedra, J; Pinera, L; Pitts, K; Plager, C; Pondrom, L; Portell, X; Poukhov, O; Pounder, N; Prakoshyn, F; Pronko, A; Proudfoot, J; Ptohos, F; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Ramakrishnan, V; Ranjan, N; Redondo, I; Reisert, B; Rekovic, V; Renton, P; Rescigno, M; Richter, S; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Roy, P; Ruiz, A; Russ, J; Rusu, V; Saarikko, H; Safonov, A; Sakumoto, W K; Salamanna, G; Saltó, O; Santi, L; Sarkar, S; Sartori, L; Sato, K; Savoy-Navarro, A; Scheidle, T; Schlabach, P; Schmidt, E E; Schmidt, M A; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scott, A L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Sexton-Kennedy, L; Sfyria, A; Shalhout, S Z; Shapiro, M D; Shears, T; Shepard, P F; Sherman, D; Shimojima, M; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Sinervo, P; Sisakyan, A; Slaughter, A J; Slaunwhite, J; Sliwa, K; Smith, J R; Snider, F D; Snihur, R; Soderberg, M; Soha, A; Somalwar, S; Sorin, V; Spalding, J; Spinella, F; Spreitzer, T; Squillacioti, P; Stanitzki, M; St Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Stuart, D; Suh, J S; Sukhanov, A; Sun, H; Suslov, I; Suzuki, T; Taffard, A; Takashima, R; Takeuchi, Y; Tanaka, R; Tecchio, M; Teng, P K; Terashi, K; Thom, J; Thompson, A S; Thompson, G A; Thomson, E; Tipton, P; Tiwari, V; Tkaczyk, S; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Tourneur, S; Trischuk, W; Tu, Y; Turini, N; Ukegawa, F; Uozumi, S; Vallecorsa, S; van Remortel, N; Varganov, A; Vataga, E; Vázquez, F; Velev, G; Vellidis, C; Veszpremi, V; Vidal, M; Vidal, R; Vila, I; Vilar, R; Vine, T; Vogel, M; Volobouev, I; Volpi, G; Würthwein, F; Wagner, P; Wagner, R G; Wagner, R L; Wagner-Kuhr, J; Wagner, W; Wakisaka, T; Wallny, R; Wang, S M; Warburton, A; Waters, D; Weinberger, M; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Williams, G; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Wright, T; Wu, X; Wynne, S M; Yagil, A; Yamamoto, K; Yamaoka, J; Yamashita, T; Yang, C; Yang, U K; Yang, Y C; Yao, W M; Yeh, G P; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanello, L; Zanetti, A; Zaw, I; Zhang, X; Zheng, Y; Zucchelli, S

    2008-05-01

    The Bc+/- meson is observed through the decay Bc+/--->J/psipi+/-, in data corresponding to an integrated luminosity of 2.4 fb(-1) recorded by the Collider Detector at Fermilab II detector at the Fermilab Tevatron. A signal of 108+/-15 candidates is observed, with a significance that exceeds 8sigma. The mass of the Bc+/- meson is measured to be 6275.6+/-2.9(stat)+/-2.5(syst) MeV/c2. PMID:18518365

  15. PREFACE: 7th International Conference on 3D Radiation Dosimetry (IC3DDose)

    NASA Astrophysics Data System (ADS)

    Thwaites, David; Baldock, Clive

    2013-06-01

    IC3DDose 2013, the 7th International Conference on 3D Radiation Dosimetry held in Sydney, Australia from 4-8 November 2012, grew out of the DosGel series, which began as DosGel99, the 1st International Workshop on Radiation Therapy Gel Dosimetry in Lexington, Kentucky. Since 1999 subsequent DoSGel conferences were held in Brisbane, Australia (2001), Ghent, Belgium (2004), Sherbrooke, Canada (2006) and Crete, Greece (2008). In 2010 the conference was held on Hilton Head Island, South Carolina and underwent a name-change to IC3DDose. The aim of the first workshop was to bring together individuals, both researchers and users, with an interest in 3D radiation dosimetry techniques, with a mix of presentations from basic science to clinical applications, which has remained an objective for all of the meetings. One rationale of DosGel99 was stated as supporting the increasing clinical implementation of gel dosimetry, as the technique appeared, at that time, to be leaving the laboratories of gel dosimetry enthusiasts and entering clinical practice. Clearly by labelling the first workshop as the 1st, there was a vision of a continuing series, which has been fulfilled. On the other hand, the expectation of widespread clinical use of gel dosimetry has perhaps not been what was hoped for and anticipated. Nevertheless the rapidly increasing demand for advanced high-precision 3D radiotherapy technology and techniques has continued apace. The need for practical and accurate 3D dosimetry methods for development and quality assurance has only increased. By the 6th meeting, held in South Carolina in 2010, the Conference Scientific Committee recognised the wider developments in 3D systems and methods and decided to widen the scope, whilst keeping the same span from basic science to applications. This was signalled by a change of name from 'Dosgel' to 'IC3DDose', a name that has continued to this latest conference. The conference objectives were: to enhance the quality and accuracy of

  16. Chronology for the Aegean Late Bronze Age 1700-1400 B.C.

    PubMed

    Manning, Sturt W; Ramsey, Christopher Bronk; Kutschera, Walter; Higham, Thomas; Kromer, Bernd; Steier, Peter; Wild, Eva M

    2006-04-28

    Radiocarbon (carbon-14) data from the Aegean Bronze Age 1700-1400 B.C. show that the Santorini (Thera) eruption must have occurred in the late 17th century B.C. By using carbon-14 dates from the surrounding region, cultural phases, and Bayesian statistical analysis, we established a chronology for the initial Aegean Late Bronze Age cultural phases (Late Minoan IA, IB, and II). This chronology contrasts with conventional archaeological dates and cultural synthesis: stretching out the Late Minoan IA, IB, and II phases by approximately 100 years and requiring reassessment of standard interpretations of associations between the Egyptian and Near Eastern historical dates and phases and those in the Aegean and Cyprus in the mid-second millennium B.C. PMID:16645092

  17. Char BC amendments for soil and sediment amelioration: BC quantification and field pilot trials

    NASA Astrophysics Data System (ADS)

    Cornelissen, G.; Braendli, R. C.; Eek, E.; Henriksen, T.; Hartnik, T.; Breedveld, G. D.

    2008-12-01

    Background Activated char BC binds organic contaminants and possibly mercury so strongly that their bioaccumulation and transport to other environmental compartments are reduced. The advantages of black carbon amendment over many other remediation methods include i) it can be used as an in situ risk reduction method, ii) the price is low, and iii) it overcomes significant controversies associated with disposal of dredged and excavated materials. In this study BC amendment is used in pilot trials in the field for soil and sediment amelioration. Quantification of amended char BC Two methods for char BC quantification were tested: i) chemothermal oxidation (CTO) at a range of temperatures and ii) wet chemical oxidation with a potassium dichromate/sulfuric acid solution. The amount of BC amended to three soils was accurately determined by CTO at 375°C. For two sediments, much of the BC disappeared during combustion at 375°C, which could probably be explained by catalytic effects caused by sediment constituents such as metals, mineral oxides and salts. Attempts to avoid these effects through rinsing with acid before combustion did not result in higher char BC recoveries. CTO at lower temperatures (325-350°C) was a feasible alternative for one of the sediments. Wet oxidation with potassium dichromate/sulfuric acid proved to effectively function for BC quantification in sediments, since almost complete BC recovery (81-92 %) was observed for both sediments, while the amount of organic carbon remaining was low (5-16 %). Field pilots Earlier, we showed the effectiveness of BC amendment in the laboratory. In the laboratory it was shown that BC amendments (2 %) reduced freely dissolved porewater concentrations (factor of 10-50) and bioaccumulation (factor of 5). This presentation will describe 50 × 50 m pilot field trials in Norway (2007-2008): Trondheim Harbor (sediment) and Drammen (soil). The presentation will focus on physical monitoring (distribution of BC in the

  18. First observation of a baryonic Bc+ decay.

    PubMed

    Aaij, R; Adeva, B; Adinolfi, M; Affolder, A; Ajaltouni, Z; Akar, S; Albrecht, J; Alessio, F; Alexander, M; Ali, S; Alkhazov, G; Alvarez Cartelle, P; Alves, A A; Amato, S; Amerio, S; Amhis, Y; An, L; Anderlini, L; Anderson, J; Andreassen, R; Andreotti, M; Andrews, J E; Appleby, R B; Aquines Gutierrez, O; Archilli, F; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Baalouch, M; Bachmann, S; Back, J J; Badalov, A; Baldini, W; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Batozskaya, V; Battista, V; Bay, A; Beaucourt, L; Beddow, J; Bedeschi, F; Bediaga, I; Belogurov, S; Belous, K; Belyaev, I; Ben-Haim, E; Bencivenni, G; Benson, S; Benton, J; Berezhnoy, A; Bernet, R; Bettler, M-O; van Beuzekom, M; Bien, A; Bifani, S; Bird, T; Bizzeti, A; Bjørnstad, P M; Blake, T; Blanc, F; Blouw, J; Blusk, S; Bocci, V; Bondar, A; Bondar, N; Bonivento, W; Borghi, S; Borgia, A; Borsato, M; Bowcock, T J V; Bowen, E; Bozzi, C; Brambach, T; van den Brand, J; Bressieux, J; Brett, D; Britsch, M; Britton, T; Brodzicka, J; Brook, N H; Brown, H; Bursche, A; Busetto, G; Buytaert, J; Cadeddu, S; Calabrese, R; Calvi, M; Calvo Gomez, M; Campana, P; Campora Perez, D; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carson, L; Carvalho Akiba, K; Casse, G; Cassina, L; Castillo Garcia, L; Cattaneo, M; Cauet, Ch; Cenci, R; Charles, M; Charpentier, Ph; Chefdeville, M; Chen, S; Cheung, S-F; Chiapolini, N; Chrzaszcz, M; Ciba, K; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Coco, V; Cogan, J; Cogneras, E; Cojocariu, L; Collins, P; Comerma-Montells, A; Contu, A; Cook, A; Coombes, M; Coquereau, S; Corti, G; Corvo, M; Counts, I; Couturier, B; Cowan, G A; Craik, D C; Cruz Torres, M; Cunliffe, S; Currie, R; D'Ambrosio, C; Dalseno, J; David, P; David, P N Y; Davis, A; De Bruyn, K; De Capua, S; De Cian, M; De Miranda, J M; De Paula, L; De Silva, W; De Simone, P; Decamp, D; Deckenhoff, M; Del Buono, L; Déléage, N; Derkach, D; Deschamps, O; Dettori, F; Di Canto, A; Dijkstra, H; Donleavy, S; Dordei, F; Dorigo, M; Dosil Suárez, A; Dossett, D; Dovbnya, A; Dreimanis, K; Dujany, G; Dupertuis, F; Durante, P; Dzhelyadin, R; Dziurda, A; Dzyuba, A; Easo, S; Egede, U; Egorychev, V; Eidelman, S; Eisenhardt, S; Eitschberger, U; Ekelhof, R; Eklund, L; El Rifai, I; Elsasser, Ch; Ely, S; Esen, S; Evans, H-M; Evans, T; Falabella, A; Färber, C; Farinelli, C; Farley, N; Farry, S; Fay, Rf; Ferguson, D; Fernandez Albor, V; Ferreira Rodrigues, F; Ferro-Luzzi, M; Filippov, S; Fiore, M; Fiorini, M; Firlej, M; Fitzpatrick, C; Fiutowski, T; Fontana, M; Fontanelli, F; Forty, R; Francisco, O; Frank, M; Frei, C; Frosini, M; Fu, J; Furfaro, E; Gallas Torreira, A; Galli, D; Gallorini, S; Gambetta, S; Gandelman, M; Gandini, P; Gao, Y; García Pardiñas, J; Garofoli, J; Garra Tico, J; Garrido, L; Gaspar, C; Gauld, R; Gavardi, L; Gavrilov, G; Geraci, A; Gersabeck, E; Gersabeck, M; Gershon, T; Ghez, Ph; Gianelle, A; Giani', S; Gibson, V; Giubega, L; Gligorov, V V; Göbel, C; Golubkov, D; Golutvin, A; Gomes, A; Gotti, C; Grabalosa Gándara, M; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graziani, G; Grecu, A; Greening, E; Gregson, S; Griffith, P; Grillo, L; Grünberg, O; Gui, B; Gushchin, E; Guz, Yu; Gys, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hall, S; Hamilton, B; Hampson, T; Han, X; Hansmann-Menzemer, S; Harnew, N; Harnew, S T; Harrison, J; He, J; Head, T; Heijne, V; Hennessy, K; Henrard, P; Henry, L; Hernando Morata, J A; van Herwijnen, E; Heß, M; Hicheur, A; Hill, D; Hoballah, M; Hombach, C; Hulsbergen, W; Hunt, P; Hussain, N; Hutchcroft, D; Hynds, D; Idzik, M; Ilten, P; Jacobsson, R; Jaeger, A; Jalocha, J; Jans, E; Jaton, P; Jawahery, A; Jing, F; John, M; Johnson, D; Jones, C R; Joram, C; Jost, B; Jurik, N; Kaballo, M; Kandybei, S; Kanso, W; Karacson, M; Karbach, T M; Karodia, S; Kelsey, M; Kenyon, I R; Ketel, T; Khanji, B; Khurewathanakul, C; Klaver, S; Klimaszewski, K; Kochebina, O; Kolpin, M; Komarov, I; Koopman, R F; Koppenburg, P; Korolev, M; Kozlinskiy, A; Kravchuk, L; Kreplin, K; Kreps, M; Krocker, G; Krokovny, P; Kruse, F; Kucewicz, W; Kucharczyk, M; Kudryavtsev, V; Kurek, K; Kvaratskheliya, T; La Thi, V N; Lacarrere, D; Lafferty, G; Lai, A; Lambert, D; Lambert, R W; Lanfranchi, G; Langenbruch, C; Langhans, B; Latham, T; Lazzeroni, C; Le Gac, R; van Leerdam, J; Lees, J-P; Lefèvre, R; Leflat, A; Lefrançois, J; Leo, S; Leroy, O; Lesiak, T; Leverington, B; Li, Y; Likhomanenko, T; Liles, M; Lindner, R; Linn, C; Lionetto, F; Liu, B; Lohn, S; Longstaff, I; Lopes, J H; Lopez-March, N; Lowdon, P; Lu, H; Lucchesi, D; Luo, H; Lupato, A; Luppi, E; Lupton, O; Machefert, F; Machikhiliyan, I V; Maciuc, F; Maev, O; Malde, S; Malinin, A; Manca, G; Mancinelli, G; Maratas, J; Marchand, J F; Marconi, U; Marin Benito, C; Marino, P; Märki, R; Marks, J; Martellotti, G; Martens, A; Martín Sánchez, A; Martinelli, M; Martinez Santos, D; Martinez Vidal, F; Martins Tostes, D; Massafferri, A; Matev, R; Mathe, Z; Matteuzzi, C; Mazurov, A; McCann, M; McCarthy, J; McNab, A; McNulty, R; McSkelly, B; Meadows, B; Meier, F; Meissner, M; Merk, M; Milanes, D A; Minard, M-N; Moggi, N; Molina Rodriguez, J; Monteil, S; Morandin, M; Morawski, P; Mordà, A; Morello, M J; Moron, J; Morris, A-B; Mountain, R; Muheim, F; Müller, K; Mussini, M; Muster, B; Naik, P; Nakada, T; Nandakumar, R; Nasteva, I; Needham, M; Neri, N; Neubert, S; Neufeld, N; Neuner, M; Nguyen, A D; Nguyen, T D; Nguyen-Mau, C; Nicol, M; Niess, V; Niet, R; Nikitin, N; Nikodem, T; Novoselov, A; O'Hanlon, D P; Oblakowska-Mucha, A; Obraztsov, V; Oggero, S; Ogilvy, S; Okhrimenko, O; Oldeman, R; Onderwater, G; Orlandea, M; Otalora Goicochea, J M; Owen, P; Oyanguren, A; Pal, B K; Palano, A; Palombo, F; Palutan, M; Panman, J; Papanestis, A; Pappagallo, M; Pappalardo, L L; Parkes, C; Parkinson, C J; Passaleva, G; Patel, G D; Patel, M; Patrignani, C; Pazos Alvarez, A; Pearce, A; Pellegrino, A; Pepe Altarelli, M; Perazzini, S; Perez Trigo, E; Perret, P; Perrin-Terrin, M; Pescatore, L; Pesen, E; Petridis, K; Petrolini, A; Picatoste Olloqui, E; Pietrzyk, B; Pilař, T; Pinci, D; Pistone, A; Playfer, S; Plo Casasus, M; Polci, F; Poluektov, A; Polycarpo, E; Popov, A; Popov, D; Popovici, B; Potterat, C; Price, E; Prisciandaro, J; Pritchard, A; Prouve, C; Pugatch, V; Puig Navarro, A; Punzi, G; Qian, W; Rachwal, B; Rademacker, J H; Rakotomiaramanana, B; Rama, M; Rangel, M S; Raniuk, I; Rauschmayr, N; Raven, G; Reichert, S; Reid, M M; Dos Reis, A C; Ricciardi, S; Richards, S; Rihl, M; Rinnert, K; Rives Molina, V; Roa Romero, D A; Robbe, P; Rodrigues, A B; Rodrigues, E; Rodriguez Perez, P; Roiser, S; Romanovsky, V; Romero Vidal, A; Rotondo, M; Rouvinet, J; Ruf, T; Ruiz, H; Ruiz Valls, P; Saborido Silva, J J; Sagidova, N; Sail, P; Saitta, B; Salustino Guimaraes, V; Sanchez Mayordomo, C; Sanmartin Sedes, B; Santacesaria, R; Santamarina Rios, C; Santovetti, E; Sarti, A; Satriano, C; Satta, A; Saunders, D M; Savrie, M; Savrina, D; Schiller, M; Schindler, H; Schlupp, M; Schmelling, M; Schmidt, B; Schneider, O; Schopper, A; Schune, M-H; Schwemmer, R; Sciascia, B; Sciubba, A; Seco, M; Semennikov, A; Sepp, I; Serra, N; Serrano, J; Sestini, L; Seyfert, P; Shapkin, M; Shapoval, I; Shcheglov, Y; Shears, T; Shekhtman, L; Shevchenko, V; Shires, A; Silva Coutinho, R; Simi, G; Sirendi, M; Skidmore, N; Skwarnicki, T; Smith, N A; Smith, E; Smith, E; Smith, J; Smith, M; Snoek, H; Sokoloff, M D; Soler, F J P; Soomro, F; Souza, D; Souza De Paula, B; Spaan, B; Sparkes, A; Spradlin, P; Sridharan, S; Stagni, F; Stahl, M; Stahl, S; Steinkamp, O; Stenyakin, O; Stevenson, S; Stoica, S; Stone, S; Storaci, B; Stracka, S; Straticiuc, M; Straumann, U; Stroili, R; Subbiah, V K; Sun, L; Sutcliffe, W; Swientek, K; Swientek, S; Syropoulos, V; Szczekowski, M; Szczypka, P; Szilard, D; Szumlak, T; T'Jampens, S; Teklishyn, M; Tellarini, G; Teubert, F; Thomas, C; Thomas, E; van Tilburg, J; Tisserand, V; Tobin, M; Tolk, S; Tomassetti, L; Tonelli, D; Topp-Joergensen, S; Torr, N; Tournefier, E; Tourneur, S; Tran, M T; Tresch, M; Tsaregorodtsev, A; Tsopelas, P; Tuning, N; Ubeda Garcia, M; Ukleja, A; Ustyuzhanin, A; Uwer, U; Vagnoni, V; Valenti, G; Vallier, A; Vazquez Gomez, R; Vazquez Regueiro, P; Vázquez Sierra, C; Vecchi, S; Velthuis, J J; Veltri, M; Veneziano, G; Vesterinen, M; Viaud, B; Vieira, D; Vieites Diaz, M; Vilasis-Cardona, X; Vollhardt, A; Volyanskyy, D; Voong, D; Vorobyev, A; Vorobyev, V; Voß, C; Voss, H; de Vries, J A; Waldi, R; Wallace, C; Wallace, R; Walsh, J; Wandernoth, S; Wang, J; Ward, D R; Watson, N K; Websdale, D; Whitehead, M; Wicht, J; Wiedner, D; Wilkinson, G; Williams, M P; Williams, M; Wilson, F F; Wimberley, J; Wishahi, J; Wislicki, W; Witek, M; Wormser, G; Wotton, S A; Wright, S; Wu, S; Wyllie, K; Xie, Y; Xing, Z; Xu, Z; Yang, Z; Yuan, X; Yushchenko, O; Zangoli, M; Zavertyaev, M; Zhang, L; Zhang, W C; Zhang, Y; Zhelezov, A; Zhokhov, A; Zhong, L; Zvyagin, A

    2014-10-10

    A baryonic decay of the B(c)(+) meson, B(c)(+) → J/ψppπ(+), is observed for the first time, with a significance of 7.3 standard deviations, in pp collision data collected with the LHCb detector and corresponding to an integrated luminosity of 3.0 fb(-1) taken at center-of-mass energies of 7 and 8 TeV. With the B(c)(+) → J/ψπ(+) decay as the normalization channel, the ratio of branching fractions is measured to be B(B(c)(+) → J/ψppπ(+))/B(B(c)(+) → J/ψπ(+)) = 0.143(-0.034)(+0.039)(stat) ± 0.013(syst). The mass of the B(c)(+) meson is determined as M(B(c)(+) = 6274.0 ± 1.8(stat) ± 0.4(syst) MeV/c(2), using the B(c)(+) → J/ψppπ(+) channel. PMID:25375705

  19. Recalibrating the BC Transfer System: Approved Final Report

    ERIC Educational Resources Information Center

    British Columbia Council on Admissions and Transfer, 2006

    2006-01-01

    In November 2005, the BC Council on Admissions and Transfer launched a consultation entitled Recalibrating the BC Transfer System with the institutional members of the BC Transfer System and other interested parties. This consultation was motivated in large part by significant changes in the BC post-secondary system over the last decade, and…

  20. PREFACE: XTOP 2004 -- 7th Biennial Conference on High Resolution X-Ray Diffraction and Imaging

    NASA Astrophysics Data System (ADS)

    Holý, Vaclav

    2005-05-01

    The 7th Biennial Conference on High Resolution X-Ray Diffraction and Imaging (XTOP 2004) was held in the Prague suburb of Pruhonice, Czech Republic, during 7-10 September 2004. It was organized by the Czech and Slovak Crystallographic Association in cooperation with the Institute of Physics, Academy of Sciences of the Czech Republic, Prague, Masaryk University, Brno, and Charles University, Prague. XTOP 2004 took place just after EPDIC IX (European Powder Diffraction Conference) organised in Prague by the same Association during 2-5 September 2004. The Organizing Committee was supported by an International Programme Committee including about 20 prominent scientists from several European and overseas countries, whose helpful suggestions for speakers are acknowledged. The conference was sponsored by the International Union of Crystallography and by several industrial sponsors; this sponsorship allowed us to support about 20 students and young scientists. In total, 147 official delegates and 8 accompanying persons from 16 countries of three continents attended our conference. The scientific programme of the conference was divided into 11 half-day sessions and 2 poster sessions. The participants presented 147 accepted contributions; of these 9 were 45-minute long invited talks, 34 were 20-minute oral presentations and 104 were posters. All posters were displayed for the whole meeting to ensure maximum exposure and interaction between delegates. We followed the very good experience from the previous conference, XTOP 2002, and also organized pre-conference tutorial lectures presented by experts in the field: `Imaging with hard synchrotron radiation' (J Härtwig, Grenoble), `High-resolution x-ray diffractometry: determination of strain and composition' (J Stangl, Linz), `X-ray grazing-incidence scattering from surfaces and nanostructures' (U Pietsch, Potsdam) and `Hard x-ray optics' (J Hrdý, Prague). According to the recommendation of the International Program Committee

  1. PREFACE: Proceedings of the 7th Liquid Matter Conference (Lund, Sweden, 27 June 1 July 2008)

    NASA Astrophysics Data System (ADS)

    Kahl, Gerhard; Sciortino, Francesco; Ullner, Magnus

    2008-12-01

    (Utrecht) and to Professor Peter Pusey (Edinburgh) for their seminal studies of colloidal matter. In addition to plenary speeches by the two recipients of the Liquid Matter Prize, the scientific program consisted of ten plenary lectures, 108 symposia talks, 23 of which were keynote lectures, and 458 poster contributions. This special issue of Journal of Physics: Condensed Matter contains 47 of the oral communications. The conference was held in the buildings of Lund University and the Student Union facing the University Square in the heart of Lund. The organizers gratefully acknowledge the substantial financial support offered by the Nobel Foundation and by the Swedish Research Council. The success of the conference owes a great debt of gratitude to the members of the Local Organizing Committee and all the people who helped them tirelessly (and very efficiently) to make the conference run smoothly and to the members of the International Program Committee, who were deeply involved in the planning of the conference. During the conference dinner our colleague Lennart Piculell gave a singing performance, which included a song dedicated to the two winners of the Liquid Matter Prize, entitled Hard-Breaking Gel, whose lyrics are printed below. Finally, the Board of the Liquids Section of the European Physical Society decided that the 8th Liquid Matter Conference will be held in Vienna (Austria) 6-10 September 2011. Hard-Breaking Gel New lyrics by Lennart Piculell to the melody of Heartbreak Hotel, created in June 2008 for the 7th Liquid Matter Conference, dedicated to Henk Lekkerkerker and Peter Pusey. Well, since my baby left me, I found a new place to be! It's downtown Lund, in a narrow street, Where hundreds of cool people meet! There I don't feel lonely, No, I don't feel lonely - So, if you feel lonely, you should try! It's all about liquid matter: Liquids flow, and soft bodies swell! Your mind is blown, and your blood will boil To a hard-breaking gel. And you won't be lonely

  2. Ferro- and antiferro-magnetism in (Np, Pu)BC

    NASA Astrophysics Data System (ADS)

    Klimczuk, T.; Shick, A. B.; Kozub, A. L.; Griveau, J.-C.; Colineau, E.; Falmbigl, M.; Wastin, F.; Rogl, P.

    2015-04-01

    Two new transuranium metal boron carbides, NpBC and PuBC, have been synthesized. Rietveld refinements of powder XRD patterns of {Np,Pu}BC confirmed in both cases isotypism with the structure type of UBC. Temperature dependent magnetic susceptibility data reveal antiferromagnetic ordering for PuBC below TN = 44 K, whereas ferromagnetic ordering was found for NpBC below TC = 61 K. Heat capacity measurements prove the bulk character of the observed magnetic transition for both compounds. The total energy electronic band structure calculations support formation of the ferromagnetic ground state for NpBC and the antiferromagnetic ground state for PuBC.

  3. Structural forms of cubic BC2N

    SciTech Connect

    Sun, Hong; Jhi, Seung-Hoon; Roundy, David; Cohen, Marvin L.; Louie, Steven G.

    2001-03-01

    Superhard cubic boron-carbonitrides (c-BC2N) are studied with the use of the ab initio pseudopotential density functional method. The total energy, lattice constant, bulk and shear moduli, and electronic band structures as well as the electron density of states are calculated for all the possible c-BC2N structures in an eight-atom zinc-blende-structured cubic unit cell. The results obtained provide a plausible explanation for recent experimental observations as well as a possible path to synthesis of the materials.

  4. Evaluation of the 7th edition of the TNM classification in patients with resected esophageal squamous cell carcinoma

    PubMed Central

    Wang, Jia; Wu, Nan; Zheng, Qing-Feng; Yan, Shi; Lv, Chao; Li, Shao-Lei; Yang, Yue

    2014-01-01

    AIM: To evaluate the prognostic factors and tumor stages of the 7th edition TNM classification for esophageal cancer. METHODS: In total, 1033 patients with esophageal squamous cell carcinoma (ESCC) who underwent surgical resection with or without (neo)adjuvant therapy between January 2003 and June 2012 at the Thoracic Surgery Department II of the Beijing Cancer Hospital, Beijing, China were included in this study. The following eligibility criteria were applied: (1) squamous cell carcinoma of the esophagus or gastroesophageal junction identified by histopathological examination; (2) treatment with esophagectomy plus lymphadenectomy with curative intent; and (3) complete pathologic reports and follow-up data. Patients who underwent non-curative (R1) resection and patients who died in hospital were excluded. Patients who received (neo)adjuvant therapy were also included in this analysis. All patients were restaged using the 7th edition of the Union for International Cancer Control and the American Joint Committee on Cancer TNM staging systems. Univariate and multivariate analyses were performed to identify the prognostic factors for survival. Survival curves were plotted using the Kaplan-Meier method, and the log-rank test was used to evaluate differences between the subgroups. RESULTS: Of the 1033 patients, 273 patients received (neo)adjuvant therapy, and 760 patients were treated with surgery alone. The median follow-up time was 51.6 mo (range: 5-112 mo) and the overall 5-year survival rate was 36.4%. Gender, “pT” and “pN” descriptors, (neo)adjuvant therapy, and the 7th edition TNM stage grouping were independent prognostic factors in the univariate and multivariate analyses. However, neither histologic grade nor cancer location were independent prognostic factors in the univariate and multivariate analyses. The 5-year stage-based survival rates were as follows: IA, 84.9%; IB, 70.9%; IIA, 56.2%; IIB, 43.3%; IIIA, 37.9%; IIIB, 23.3%; IIIC,12.9% and IV, 3

  5. Accountability of the BC Transfer System

    ERIC Educational Resources Information Center

    British Columbia Council on Admissions and Transfer, 2005

    2005-01-01

    The purpose of the paper is to provide evidence that the Transfer System in British Columbia (BC) has been effective and therefore accountable for the public funding that supports that system. The paper attempts to show: (1) the multi-faceted nature, breadth and depth of research that has been conducted to determine the effectiveness of the BC…

  6. Bc production in Higgs boson decays

    NASA Astrophysics Data System (ADS)

    Jiang, Jun; Qiao, Cong-Feng

    2016-03-01

    The Bc production rate in Higgs boson decays is evaluated in the nonrelativistic QCD framework. Given that the Higgs total decay width is about 4.20 MeV and the vector Bc* meson decays completely to the ground state, we find that the branching fraction of Bc meson production in Higgs decays is 8.50 ×10-4, where both leading QCD and QED contributions are included. This process is hence detectable in the high-luminosity/-energy LHC. It is found that the coupling of H b b ¯ dominates the processes, and contributions from the triangle top-quark loop and other couplings (H c c ¯, H W W and H Z Z ) are small. In confronting the quarkonia production, we find that the fraction rate of Bc production is more than an order of magnitude bigger than those of charmonium and bottomonium production in Higgs decays. Moreover, various uncertainties and differential distributions of the concerned processes are analyzed carefully.

  7. Diversity in BC Schools: A Framework

    ERIC Educational Resources Information Center

    British Columbia Ministry of Education, 2004

    2004-01-01

    Diversity in BC schools is an overarching concept that reflects a philosophy of equitable participation and an appreciation of the contributions of all people. It is a concept that refers both to our uniqueness as individuals and to our sense of belonging or identification within a group or groups. Diversity refers to the ways in which we differ…

  8. Eight BC Workforce Literacy Initiatives. Final Report.

    ERIC Educational Resources Information Center

    Literacy British Columbia, Vancouver.

    Eight work force literacy initiatives were conducted in British Columbia (BC), Canada. The primary objectives and key activities of the initiatives were as follows: (1) alliance development (developing partnerships and linkages promoting and supporting work force literacy); (2) public awareness (conducting presentations and media relations and…

  9. Multi-MW K-Band 7th Harmonic Multiplier for High-Gradient Accelerator R&D

    SciTech Connect

    Solyak, N.A.; Yakovlev, V.P.; Hirschfield, J.L.; Kazakevich, G.M.; LaPointe, M.A.; /Yale U.

    2009-05-01

    A preliminary design and current status are presented for a two-cavity 7th harmonic multiplier, intended as a high-power RF source for use in experiments aimed at developing high-gradient structures for a future collider. The harmonic multiplier is to produce power in K-band using as its RF driver an XK-5 S-band klystron (2.856 GHz). The multiplier is to be built with a TE{sub 111} rotating mode input cavity and interchangeable output cavities, a principal example being a TE{sub 711} rotating mode cavity running at 20 GHz. The design that is described uses a 250 kV, 20 A injected laminar electron beam. With 8.5 MW of S-band drive power, 4.4 MW of 20-GHz output power is predicted. The design uses a gun, magnetic coils, and beam collector from an existing waveguide 7th harmonic multiplier. The gun has been re-conditioned and the desired operating parameters have been achieved.

  10. China: The Exchange of Goods and Ideas along the Silk Road. A Lesson for 7th Grade World History.

    ERIC Educational Resources Information Center

    Alton, Shelley; Bernstein-Potter, Gordon; Bohuchot, Aimee; Hott, Sheryl; Pisi, Frank

    This lesson plan focuses on China's Silk Road (300 B.C.-1300 A.D.), specifically the exchange of goods and ideas along its route. The lesson consists of four activities: (1) "Geography"; (2) "Matrix"; (3) "Advertisement"; and (4) "Oral Presentation." The lesson presents goals, provides background, and outlines the context of the lesson. It cites…

  11. Overview and research agenda arising from the 7th World Workshop on Oral Health and Disease in AIDS.

    PubMed

    Tappuni, A R; Shiboski, C

    2016-04-01

    The Research Agenda generated by the 7th World Workshop on Oral Health and Disease in AIDS (WW7) is delivered in this paper. Panels of international experts presided over nine workshops that constituted the conference held in November 2014 in Hyderabad, India. The main goal of the Workshop was to bring together clinician and scientists interested in the subject to debate with world-wide perspectives current issues related to the oral manifestations in HIV/AIDS. The workshops were structured around three themes; basic science, clinical/translational science and social science and were attended by 135 participants from 31 countries. The research questions debated at the workshops are presented in nine consensus papers published in this issue and are summarised in this paper along with an outline of the identified research needs in the field. PMID:27109289

  12. Thales of Miletus (624-546 BC)

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    The first known Greek philosopher; also a scientist, mathematician and engineer, born in Miletus, Asia Minor (now Turkey), believed to have been the teacher of ANAXIMANDER. Apparently wrote a book on navigation, defining the constellation Ursa Minor and using it as a navigation aid. Credited with the prediction of an eclipse of the Sun in 585 BC, although it is not known how, since the Metonic cy...

  13. Symmetry Properties of Single-Walled BC2N Nanotubes

    SciTech Connect

    Pan, Hui; Feng, Yuan Ping; Lin, Jainyi

    2009-06-01

    The symmetry properties of the single-walled BC2N nanotubes were investigated. All the BC2N nanotubes possess nonsymmorphic line groups. In contrast with the carbon and boron nitride nanotubes, armchair and zigzag BC2N nanotubes belong to different line groups, depending on the index n (even or odd) and the vector chosen. The number of Raman- active phonon modes is almost twice that of the infrared-active phonon modes for all kinds of BC2N nanotubes.

  14. Geographic origin and evolutionary history of China's two predominant HIV-1 circulating recombinant forms, CRF07_BC and CRF08_BC.

    PubMed

    Feng, Yi; Takebe, Yutaka; Wei, Huamian; He, Xiang; Hsi, Jenny H; Li, Zhenpeng; Xing, Hui; Ruan, Yuhua; Yang, Yao; Li, Fan; Wei, Jing; Li, Xingguang; Shao, Yiming

    2016-01-01

    To determine the origin and evolutionary history of two predominant and closely-related circulating recombinant forms (CRF07_BC and CRF08_BC), recombinant structures and phylogenies of 7 unique recombinant forms comprised of subtypes of B' (Thai B linage) and C (designated URFs_BC) from archival specimens of injection drug users (IDUs) collected in 1996 to 1998 from western Yunnan and 4 circulating recombinant forms with B'/C recombinants recently identified (designated nCRFs_BC) in China were compared with those of CRF07_BC and CRF08_BC. The results showed that 5 of 7 URFs_BC and all the nCRFs_BC shared recombination breakpoints with CRF07_BC and/or CRF08_BC. Yunnan URFs_BC consistently occupied the basal branch positions compared with CRF07_BC, CRF08_BC, and nCRFs_BC in phylogenetic trees. The estimated most recent common ancestors (tMRCA) for Yunnan URFs_BC were from ~1987, approximately half a decade earlier than those for CRF07_BC (~1994) and CRF08_BC (~1992). Discrete phylogeographic and spatial diffusion analysis revealed that both CRF07_BC and CRF08 BC came from western Yunnan in the early 1990s. Our results provide compelling evidence for western Yunnan as the geographic origin of CRF07_BC and CRF08_BC, which emerged from a swarm of URFs_BC by a series of recombination events in western Yunnan in the early 1990s. PMID:26763952

  15. A forensic hypothesis for the mystery of al-Hasan’s death in the 7th century: Mercury(I) chloride intoxication

    PubMed Central

    Burke, Nicole; Golas, Mitchell; Raafat, Cyrus L.

    2015-01-01

    The puzzle of a mysterious death in the Middle Ages has been hypothesized in terms of contemporary forensic legal and scientific methods. That al-Hasan ibn-‘Ali died in 669 aged just 45 has been forensically analyzed based on written sources that dictate eyewitness accounts of historical events. The report of the contemporaneous poisoning of another individual who resided under the same household as al-Hasan’s and experienced similar, yet non-lethal, symptoms has served as the beginning of the analysis. In light of ancient (medieval) documents and through using mineralogical, medical, and chemical facts, it has been hypothesized that mineral calomel (mercury(I) chloride, Hg2Cl2) from a certain region in the Byzantine Empire (present-day western Turkey) was the substance primarily responsible for the murder of al-Hasan. PMID:26377933

  16. Transformation: Reinforcing Bridges to the 21st Century: Proceedings of the Annual Missouri Conference on Blacks in Higher Education (7th, Kirksville, Missouri, April 24-25, 1997).

    ERIC Educational Resources Information Center

    Dawson-Threat, Janice, Ed.

    These proceedings present summaries of presentations and roundtable discussion sessions from a Missouri Conference on Blacks in Higher Education. Session summaries are: (1) "Measuring Inter-Racial Differences and Attitudes" (O.C. Bobby Daniels); (2) "Flight of the Maple Leaf Canada Economic Outlook: Impact on Women" (James E. Bell); (3) "Bridging…

  17. "Relating in a Global Community." Proceedings of the International Conference on Counseling in the 21st Century (7th, Sydney, Australia, December 29-31, 1998.)

    ERIC Educational Resources Information Center

    1998

    The papers presented at this conference consider the many roles counselors play in people's lives throughout their lifespan. The age of technology has aided the practice of counseling in becoming international in scope, although there are different functional frameworks that exist in various political, economic, social, and value systems in world…

  18. A forensic hypothesis for the mystery of al-Hasan's death in the 7th century: Mercury(I) chloride intoxication.

    PubMed

    Burke, Nicole; Golas, Mitchell; Raafat, Cyrus L; Mousavi, Aliyar

    2016-07-01

    The puzzle of a mysterious death in the Middle Ages has been hypothesized in terms of contemporary forensic legal and scientific methods. That al-Hasan ibn-'Ali died in 669 aged just 45 has been forensically analyzed based on written sources that dictate eyewitness accounts of historical events. The report of the contemporaneous poisoning of another individual who resided under the same household as al-Hasan's and experienced similar, yet non-lethal, symptoms has served as the beginning of the analysis. In light of ancient (medieval) documents and through using mineralogical, medical, and chemical facts, it has been hypothesized that mineral calomel (mercury(I) chloride, Hg2Cl2) from a certain region in the Byzantine Empire (present-day western Turkey) was the substance primarily responsible for the murder of al-Hasan. PMID:26377933

  19. Evaluation of Cotton Leaf Curl Virus Resistance in BC1, BC2, and BC3 Progenies from an Interspecific Cross between Gossypium arboreum and Gossypium hirsutum

    PubMed Central

    Nazeer, Wajad; Tipu, Abdul Latif; Ahmad, Saghir; Mahmood, Khalid; Mahmood, Abid; Zhou, Baoliang

    2014-01-01

    Cotton leaf curl virus disease (CLCuD) is an important constraint to cotton production. The resistance of G. arboreum to this devastating disease is well documented. In the present investigation, we explored the possibility of transferring genes for resistance to CLCuD from G. arboreum (2n = 26) cv 15-Mollisoni into G. hirsutum (2n = 52) cv CRSM-38 through conventional breeding. We investigated the cytology of the BC1 to BC3 progenies of direct and reciprocal crosses of G. arboreum and G. hirsutum and evaluated their resistance to CLCuD. The F1 progenies were completely resistant to this disease, while a decrease in resistance was observed in all backcross generations. As backcrossing progressed, the disease incidence increased in BC1 (1.7–2.0%), BC2 (1.8–4.0%), and BC3 (4.2–7.0%). However, the disease incidence was much lower than that of the check variety CIM-496, with a CLCuD incidence of 96%. Additionally, the disease incidence percentage was lower in the direct cross 2(G. arboreum)×G. hirsutum than in that of G. hirsutum×G. arboreum. Phenotypic resemblance of BC1 ∼BC3 progenies to G. arboreum confirmed the success of cross between the two species. Cytological studies of CLCuD-resistant plants revealed that the frequency of univalents and multivalents was high in BC1, with sterile or partially fertile plants, but low in BC2 (in both combinations), with shy bearing plants. In BC3, most of the plants exhibited normal bearing ability due to the high frequency of chromosome associations (bivalents). The assessment of CLCuD through grafting showed that the BC1 to BC3 progenies were highly resistant to this disease. Thus, this study successfully demonstrates the possibility of introgressing CLCuD resistance genes from G. arboreum to G. hirsutum. PMID:25372141

  20. 75 FR 16513 - B&C Corporation, JR Engineering Division, Including B&C Distribution Center, Including On-Site...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ..., Ohio. The notice was published in the Federal Register on November 17, 2009 (74 FR 59253). At the... Employment and Training Administration B&C Corporation, JR Engineering Division, Including B&C Distribution Center, Including On-Site Leased Workers From B&C Services, Inc., Barberton, OH; Amended...

  1. Geographic origin and evolutionary history of China’s two predominant HIV-1 circulating recombinant forms, CRF07_BC and CRF08_BC

    PubMed Central

    Feng, Yi; Takebe, Yutaka; Wei, Huamian; He, Xiang; Hsi, Jenny H.; Li, Zhenpeng; Xing, Hui; Ruan, Yuhua; Yang, Yao; Li, Fan; Wei, Jing; Li, Xingguang; Shao, Yiming

    2016-01-01

    To determine the origin and evolutionary history of two predominant and closely-related circulating recombinant forms (CRF07_BC and CRF08_BC), recombinant structures and phylogenies of 7 unique recombinant forms comprised of subtypes of B’ (Thai B linage) and C (designated URFs_BC) from archival specimens of injection drug users (IDUs) collected in 1996 to 1998 from western Yunnan and 4 circulating recombinant forms with B’/C recombinants recently identified (designated nCRFs_BC) in China were compared with those of CRF07_BC and CRF08_BC. The results showed that 5 of 7 URFs_BC and all the nCRFs_BC shared recombination breakpoints with CRF07_BC and/or CRF08_BC. Yunnan URFs_BC consistently occupied the basal branch positions compared with CRF07_BC, CRF08_BC, and nCRFs_BC in phylogenetic trees. The estimated most recent common ancestors (tMRCA) for Yunnan URFs_BC were from ~1987, approximately half a decade earlier than those for CRF07_BC (~1994) and CRF08_BC (~1992). Discrete phylogeographic and spatial diffusion analysis revealed that both CRF07_BC and CRF08 BC came from western Yunnan in the early 1990s. Our results provide compelling evidence for western Yunnan as the geographic origin of CRF07_BC and CRF08_BC, which emerged from a swarm of URFs_BC by a series of recombination events in western Yunnan in the early 1990s. PMID:26763952

  2. Ferro- and antiferro-magnetism in (Np, Pu)BC

    SciTech Connect

    Klimczuk, T.; Kozub, A. L.; Griveau, J.-C.; Colineau, E.; Wastin, F.; Falmbigl, M.; Rogl, P.

    2015-04-01

    Two new transuranium metal boron carbides, NpBC and PuBC, have been synthesized. Rietveld refinements of powder XRD patterns of (Np,Pu)BC confirmed in both cases isotypism with the structure type of UBC. Temperature dependent magnetic susceptibility data reveal antiferromagnetic ordering for PuBC below T{sub N} = 44 K, whereas ferromagnetic ordering was found for NpBC below T{sub C} = 61 K. Heat capacity measurements prove the bulk character of the observed magnetic transition for both compounds. The total energy electronic band structure calculations support formation of the ferromagnetic ground state for NpBC and the antiferromagnetic ground state for PuBC.

  3. Archeomagnetic Intensity Variations During the 6th Millennium BC in the Middle East: New Data from Yarim Tepe II (Northern Iraq)

    NASA Astrophysics Data System (ADS)

    Akimova, S.; Gallet, Y.; Amirov, S.

    2015-12-01

    During the seventies, Soviet archeologists conducted in Northern Iraq excavations of several ancient settlements dated from the Pottery Late Neolithic period (7th and 6th millennia BC). A very large collection of artifacts unearthed from these sites, in particular several thousands of well-documented pottery fragments, is now stored at the Archeological Institute in Moscow. We collected a time-sequential series of groups of potsherds from the multilayered settlement called Yarim Tepe II dated to the Halaf period (6th millennium BC). Each group comprises a minimum of 3 potsherds (up to 10) found within a same archeological layer, typically a thickness of about 20 cm. Altogether, the fragment groups encompass the entire 7-m thick stratigraphic sequence of Yarim Tepe II. We will present our first archeointensity results obtained using the experimental protocol developed for the Triaxe magnetometer, taking into account the effects of both the thermoremanent magnetization (TRM) anisotropy and the cooling rate dependence on TRM acquisition. The new data help to better constrain the geomagnetic field intensity variations in the Middle East during the 6th millennium BC. Thanks to the comparison with other datasets from Bulgaria and Syria, the new archeointensity results provide evidence for the occurrence of very rapid geomagnetic field intensity variations around 5500 BC.

  4. EDITORIAL: Proceedings of the 7th International LISA Symposium, Barcelona, Spain, 16-20 June 2008 Proceedings of the 7th International LISA Symposium, Barcelona, Spain, 16-20 June 2008

    NASA Astrophysics Data System (ADS)

    Lobo, Alberto; Sopuerta, Carlos F.

    2009-05-01

    In June 2006 the LISA International Science Team (LIST) accepted the bid presented by the Institut d'Estudis Espacials de Catalunya (IEEC) to host the 7th International LISA Symposium. This was during its 11th meeting at the University of Maryland, just before the 6th edition of the symposium started at NASA's Goddard Space Flight Center. The 7th International LISA Symposium took place in the city of Barcelona, Spain, 16-20 June, 2008, in the premises of CosmoCaixa, a modern science museum located in the hills near Tibidabo. Almost 240 delegates registered for the event, a record breaking figure compared to previous editions of the symposium. Many of the most renowned world experts in LISA, gravitational wave science, and astronomy, as well as engineers, attended LISA #7 and produced state of the art presentations, while everybody benefited from the opportunity to have live discussions during the week in a friendly environment. The programme included 31 invited plenary lectures in the mornings, and eight parallel sessions in the afternoons. These were classified into seven major areas of research: LISA Technology, LISA PathFinder, LISA PathFinder Data Analysis, LISA Data Analysis, Gravitational Wave Sources, Cosmology and Fundamental Physics with LISA and Other Gravitational Wave Detectors. Abstracts for 138 communications were received, from which a selection was made by the session convenors which would fit time constraints. Up to 63 posters completed the scientific programme. More details on the programme, including some of the talks, can be found at the symposium website:http://www.ice.cat/research/LISA_Symposium. There was, however, a remarkable add-on: Professor Clifford Will delivered a startling presentation to the general public, who completely filled the Auditori—the main conference room, 320 seats—and were invited to ask questions to the speaker who boldly guided them through the daunting world of Black Holes, Waves of Gravity, and other Warped Ideas

  5. Evaluation of the 7th edition of the UICC-AJCC tumor, node, metastasis classification for esophageal cancer in a Chinese cohort

    PubMed Central

    Huang, Yan; Guo, Weigang; Shi, Shiming

    2016-01-01

    Background To assess and evaluate the prognostic value of the 7th edition of the Union for International Cancer Control–American Joint Committee on Cancer (UICC-AJCC) tumor, node, metastasis (TNM) staging system for Chinese patients with esophageal cancer in comparison with the 6th edition. Methods A retrospective review was performed on 766 consecutive esophageal cancer patients treated with esophagectomy between 2008 and 2012. Patients were staged according to the 6th and 7th editions for esophageal cancer respectively. Survival was calculated by the Kaplan-Meier method, and multivariate analysis was performed using Cox regression model. Results Overall 3-year survival rate was 59.5%. There were significant differences in 3-year survival rates among T stages both according to the 6th edition and the 7th edition (P<0.001). According to the 7th edition, the 3-year survival rates of N0 (75.4%), N1 (65.2%), N2 (39.7%) and N3 (27.3%) patients were significant differences (P<0.001). Kaplan-Meier curve revealed a good discriminatory ability from stage I to IV, except for stage IB, IIA and IIB in the 7th edition staging system. Based on the 7th edition, the degree of differentiation, tumor length and tumor location were not independent prognostic factors on multivariate analysis. The multivariate analyses suggested that pT-, pN-, pTNM-category were all the independent prognostic factors based on the 6th and 7th edition staging system. Conclusions The 7th edition of AJCC TNM staging system of esophageal cancer should discriminate pT2–3N0M0 (stage IB, IIA and IIB) better when considering the esophageal squamous cell cancer patients. Therefore, to improve and optimize the AJCC TNM classification for Chinese patients with esophageal cancer, more considerations about the value of tumor grade and tumor location in pT2–3N0M0 esophageal squamous cell cancer should be taken in the next new TNM staging system. PMID:27499956

  6. Ethical review of projects involving non-human primates funded under the European Union's 7th Research Framework Programme.

    PubMed

    Sauer, Ursula; Phillips, Barry; Reid, Kirsty; Schmit, Véronique; Jennings, Maggy

    2013-09-01

    Internet searches were performed on projects involving non-human primates ('primates') funded under the European Union (EU) 7th Research Framework Programme (FP7), to determine how project proposals are assessed from an ethical point of view. Due to the incompleteness of the information publicly available, the types and severity of the experiments could not be determined with certainty, although in some projects the level of harm was considered to be 'severe'. Information was scarce regarding the numbers of primates, their sourcing, housing, care and fate, or the application of the Three Rs within projects. Project grant holders and the relevant Commission officer were consulted about their experiences with the FP7 ethics review process. Overall, it was seen as meaningful and beneficial, but some concerns were also noted. Ethical follow-up during project performance and upon completion was recognised as a valuable tool in ensuring that animal welfare requirements were adequately addressed. Based upon the outcome of the survey, recommendations are presented on how to strengthen the ethical review process under the upcoming Framework Programme 'Horizon 2020', while adequately taking into account the specific requirements of Directive 2010/63/EU, with the aim of limiting the harms inflicted on the animals and the numbers used, and ultimately, replacing the use of primates altogether. PMID:24168134

  7. Bond Strength of 5th, 6th and 7th Generation Bonding Agents to Intracanal Dentin of Primary Teeth

    PubMed Central

    Afshar, Hossein; Baradaran Nakhjavani, Yahya; Rahro Taban, Sedighe; Baniameri, Zahra; Nahvi, Azam

    2015-01-01

    Objectives: This in-vitro study sought to assess the push-out bond strength of a total etch and 2 self-etch bonding systems to intracanal dentin of primary anterior teeth (PAT). Materials and Methods: Thirty-six primary anterior teeth were randomly divided into 3 groups of 5th generation (Single Bond 2), 6th generation (Clearfil SE) and 7th generation (Single Bond Universal) bonding agents. The canal orifice was restored with composite resin and the push-out test was carried out to assess the bond strength. After applying the push-out load, specimens were evaluated under a light microscope at 40X magnification. One-way ANOVA and log-rank test on Kaplan-Meier curves were applied for the comparison of bond strength among the 3 groups. Results: The mean± standard deviation (SD) bond strength was 13.6±5.33 MPa for Single Bond 2, 13.85±5.86 MPa for Clearfil SE and 12.28±5.24 MPa for Single Bond Universal. The differences in bond strength among the 3 groups were not statistically significant (P>0.05). Conclusion: All three bonding agents are recommended for use with composite posts in PAT. However, due to high technical sensitivity of the Total Etch system, single or two-step self etch systems may be preferred for uncooperative children. PMID:26056518

  8. Adherence and delivery: Implementation quality and program outcomes for the 7th grade keepin’ it REAL program

    PubMed Central

    Pettigrew, Jonathan; Graham, John W.; Miller-Day, Michelle; Hecht, Michael L.; Krieger, Janice L.; Shin, Young Ju

    2014-01-01

    Poor implementation quality (IQ) is known to reduce program effects making it important to consider IQ for evaluation and dissemination of prevention programs. However, less is known about the ways specific implementation variables relate to outcomes. In this study, two versions of the keepin’ it REAL, 7th grade drug prevention intervention were implemented in 78 classrooms in 25 schools in rural districts in Pennsylvania and Ohio. IQ was measured through observational coding of 276 videos. IQ variables included adherence to the curriculum, teacher engagement (attentiveness, enthusiasm, seriousness, clarity, positivity), student engagement (attention, participation), and a global rating of teacher delivery quality. Factor analysis showed that teacher engagement, student engagement, and delivery quality formed one factor, which was labeled delivery. A second factor was adherence to the curriculum. Self-report student surveys measured substance use, norms (beliefs about prevalence and acceptability of use), and efficacy (beliefs about one’s ability to refuse substance offers) at two waves (pretest, immediate posttest). Mixed model regression analysis which accounted for missing data and controlled for pretest levels examined implementation quality’s effects on individual level outcomes, statistically controlling for cluster level effects. Results show that when implemented well, students show positive outcomes compared to students receiving a poorly implemented program. Delivery significantly influenced substance use and norms, but not efficacy. Adherence marginally significantly predicted use and significantly predicted norms, but not efficacy. Findings underscore the importance of comprehensively measuring and accounting for IQ, particularly delivery, when evaluating prevention interventions. PMID:24442403

  9. The Effect of Learning Geometry Topics of 7th Grade in Primary Education with Dynamic Geometer's Sketchpad Geometry Software to Success and Retention

    ERIC Educational Resources Information Center

    Kesan, Cenk; Caliskan, Sevdane

    2013-01-01

    The aim of this study is to investigate the effect of learning geometry topics of 7th grade in primary education with dynamic geometer's sketchpad geometry software to student's success and retention. The experimental research design with The Posttest-Only Control Group was used in this study. In the experimental group, dynamic geometer's…

  10. Assessing the Development of Environmental Virtue in 7th and 8th Grade Students in an Expeditionary Learning Outward Bound School

    ERIC Educational Resources Information Center

    Martin, Bruce; Bright, Alan; Cafaro, Philip; Mittelstaedt, Robin; Bruyere, Brett

    2009-01-01

    This study attempted to assess the development of environmental virtue in 7th and 8th grade students in an Expeditionary Learning Outward Bound (ELOB) school using an instrument developed for this study--the Children's Environmental Virtue Scale (CEVS). Data for this study were obtained by administering the CEVS survey (pretest and posttest) to…

  11. Evolutionary generation of 7th order Runge - Kutta - Nyström type methods for solving y(4) = f(x,y)

    NASA Astrophysics Data System (ADS)

    Papakostas, S. N.; Tsitmidelis, S.; Tsitouras, Ch.

    2015-12-01

    We present a 7th algebraic order Runge - Kutta - Nyström method for the solution of a special fourth order initial value problem. To achieve this, a set of non - linear equations is solved using differential evolution technique. Various numerical tests justify our efforts.

  12. Influence of Skip Patterns on Item Non-Response in a Substance Use Survey of 7th to 12th Grade Students

    ERIC Educational Resources Information Center

    Ding, Kele; Olds, R. Scott; Thombs, Dennis L.

    2009-01-01

    This retrospective case study assessed the influence of item non-response error on subsequent response to questionnaire items assessing adolescent alcohol and marijuana use. Post-hoc analyses were conducted on survey results obtained from 4,371 7th to 12th grade students in Ohio in 2005. A skip pattern design in a conventional questionnaire…

  13. Investigation of Change in Adolescent Perceptions of Mothers' and Fathers' Contributions to Interparental Discord from 7th to 9th Grades

    ERIC Educational Resources Information Center

    Parra, Gilbert R.; Jobe-Shields, Lisa; Kitzmann, Katherine M.; Luebbe, Aaron M.; Olsen, James P.; Davis, Genevieve L.

    2011-01-01

    The purpose of the present study was to examine whether adolescent perceptions of mothers' and fathers' contributions to interparental discord changed from early to middle adolescence and if the changes were related to adolescent negative mood. Data were drawn from the National Longitudinal Survey of Youth 1997. Adolescents who were in 7th grade…

  14. Determining the Effects of Using Different Writing Activities on the Academic Achievements Secondary School 7th Grade Students and Their Attitudes Towards the Course

    ERIC Educational Resources Information Center

    Uzoglu, Mustafa

    2014-01-01

    The purpose of the study is to determine the effects of using writing activities with different learning purposes by the secondary school 7th grade students on their academic achievement and attitudes towards the course. The study was carried out in a secondary school located in the centre of Erzurum in 2012-2013 academic year; the study is a…

  15. Making the Grade: Do Nebraska Teachers and Administrators Working in Public Schools in 7th-12th Grade Settings Agree about What Constitutes Sound Grading Practice?

    ERIC Educational Resources Information Center

    Olson, Mark E.

    2013-01-01

    In this study, the researcher sought to determine whether Nebraska teachers and administrators agreed about what constitutes sound grading practice. The results of this study indicated that Nebraska teachers and administrators working in public schools in 7th-12th grade settings did not always agree about what constituted sound grading practice.…

  16. Significance of the lymph nodes in the 7th station in rational dissection for metastasis of distal gastric cancer with different T categories

    PubMed Central

    Song, Wu; Wang, Shaochuan; He, Weiling; Xu, Jianbo

    2014-01-01

    Objective To determine the clinicopathological characteristics, and evaluate the appropriate extent of lymph node dissection in distal gastric cancer patients with comparable T category. Methods A retrospective study was conducted on 570 distal gastric cancer patients, who underwent gastric resection with D2 nodal dissection, which was performed by the same surgical team from January 1997 to January 2011. We compared the differences in lymph node metastasis rates and metastatic lymph node ratios between different T categories. Additionally, we investigated the impact of lymph node metastasis in the 7th station on survival rate of distal gastric cancer patients with the same TNM staging. Results Among the 570 patients, the overall lymph node metastasis rate of advanced distal gastric cancer was 78.1%, and the metastatic lymph node ratio was 27%. The lymph node metastasis rate in the 7th station was similar to that of perigastric lymph nodes. There was no statistical significance in patients with the same TNM stage (stage II and III), irrespective of the metastatic status in the 7th station. Conclusions Our results suggest that to a certain extent, it is reasonable to include lymph nodes in the 7th station in the D1 lymph node dissection. PMID:25232215

  17. Studying the Ability of 7th Grade Students to Define the Circle and Its Elements in the Context of Mathematical Language

    ERIC Educational Resources Information Center

    Akarsu, Esra; Yilmaz, Süha

    2015-01-01

    In this study, it was aimed to study the mathematical language skills that the 7th grade students use in defining the circle and its elements. In the study, the mathematical language skills of students that they use in defining the circle and its elements in a scenario were compared to the mathematical language skills they use in defining them…

  18. The high-pressure semiconducting phase of LiBC

    NASA Astrophysics Data System (ADS)

    Zhang, Meiguang

    2016-04-01

    A high-pressure hexagonal semiconducting phase (space group P63mc , 2f.u./cell) of LiBC stable above 108 GPa was predicted through first-principles calculations combined with unbiased swarm structure searching techniques. This new phase consisted of three-dimensional B-C networks which originate from the dramatic out-of-plane distortions of the graphene-like B-C sublattice in the low-pressure P63/mmc phase under compression. Contrary to the metallizations of LiBC under high pressure previously proposed, the resulting three-dimensional B-C framework lacks the system of π bonds with mobile electrons and has more localized electrons, as a result of the semiconducting nature of this high-pressure LiBC phase.

  19. Prognostic Impact of the 6th and 7th American Joint Committee on Cancer TNM Staging Systems on Esophageal Cancer Patients Treated With Chemoradiotherapy

    SciTech Connect

    Nomura, Motoo; Shitara, Kohei; Kodaira, Takeshi; Hatooka, Shunzo; Mizota, Ayako; Kondoh, Chihiro; Yokota, Tomoya; Takahari, Daisuke; Ura, Takashi; Muro, Kei

    2012-02-01

    Purpose: The new 7th edition of the American Joint Committee on Cancer TNM staging system is based on pathologic data from esophageal cancers treated by surgery alone. There is no information available on evaluation of the new staging system with regard to prognosis of patients treated with chemoradiotherapy (CRT). The objective of this study was to evaluate the prognostic impact of the new staging system on esophageal cancer patients treated with CRT. Methods and Materials: A retrospective review was performed on 301 consecutive esophageal squamous cell carcinoma patients treated with CRT. Comparisons were made of the prognostic impacts of the 6th and 7th staging systems and the prognostic impacts of stage and prognostic groups, which were newly defined in the 7th edition. Results: There were significant differences between Stages I and III (p < 0.01) according to both editions. However, the 7th edition poorly distinguishes the prognoses of Stages III and IV (p = 0.36 by multivariate analysis) in comparison to the 6th edition (p = 0.08 by multivariate analysis), although these differences were not significant. For all patients, T, M, and gender were independent prognostic factors by multivariate analysis (p < 0.05). For the Stage I and II prognostic groups, survival curves showed a stepwise decrease with increase in stage, except for Stage IIA. However, there were no significant differences seen between each prognostic stage. Conclusions: Our study indicates there are several problems with the 7th TNM staging system regarding prognostic factors in patients undergoing CRT.

  20. Can we improve breast cancer mortality in Okinawa? Consensus of the 7th Okinawa Breast Oncology Meeting.

    PubMed

    Tamaki, Kentaro; Tamaki, Nobumitsu; Kamada, Yoshihiko; Uehara, Kano; Zaha, Hisamitsu; Onomura, Mai; Ueda, Makoto; Kurashita, Kaname; Miyazato, Keiko; Higa, Junko; Miyara, Kyuichiro; Shiraishi, Makiko; Murayama, Shigemi; Ishida, Takanori

    2015-01-01

    The rate of breast cancer mortality in Okinawa has gradually been increasing up to 2010. Now Okinawa has the second worst mortality rate in Japan, in part due to the enormous dietary changes resulting from the post-World War II US military occupation, high incidence of obesity, high non-optimal treatment rate, and low breast-cancer screening rate. To reduce breast cancer mortality in Okinawa, we established the Okinawa Breast Oncology Meeting (OBOM) in 2012. At the 7th OBOM held on January 10th, 2014, we discussed the breast cancer mortality in Okinawa focusing on lifestyle, breast cancer screening and optimal treatments. The Okinawan women who were overweight and/or obese during premenopausal and postmenopausal ages had a statistically significant higher risk of breast cancer development compared to those with non-overweight and/or obese women. The traditional diet of Okinawa consists of foods low in calories but rich in nutritional value. Therefore, we recommend Okinawan people not to forget the Okinawan traditional lifestyle, and to reduce their bodyweight to prevent breast cancer. One of the main goals of the OBOM is to raise breast cancer screening attendance rates to 50% (29.2% in 2010). We should standardize the quality control for breast cancer screening in Okinawa. It is important to continue enlightening the Okinawan population to receive optimal treatment. In addition, we are striving to establish systematic medical cooperation between the hospitals specializing in breast cancer treatment with rural hospitals. The OBOM group endeavors to contribute to the improvement of breast cancer mortality in Okinawa. PMID:25749491

  1. EU-funded malaria research under the 6th and 7th Framework Programmes for research and technological development.

    PubMed

    Holtel, Andreas; Troye-Blomberg, Marita; Penas-Jimenez, Inmaculada

    2011-01-01

    While malaria research has traditionally been strong in Europe, targeted and sustained support for cooperative malaria research at EU level, namely through the EU's 6th and 7th Framework Programmes for research and technological development, FP6 (2002-2006) and FP7 (2007-2013), has boosted both impact and visibility of European malaria research. Most of the European malaria research community is now organized under a number of comprehensive and complementary research networks and projects, assembled around four key areas: (1) fundamental research on the malaria parasite and the disease, (2) development of new malaria drugs, (3) research and development of a malaria vaccine, and (4) research to control the malaria-transmitting mosquito vector. Considerable efforts were undertaken to ensure adequate participation of research groups from disease-endemic countries, in particular from Africa, with the long-term aim to strengthen cooperative links and research capacities in these countries. The concept of organizing European research through major strategic projects to form a "European Research Area" (ERA) was originally developed in the preparation of FP6, and ERA formation has now turned into a major EU policy objective explicitly inscribed into the Lisbon Treaty. EU-funded malaria research may serve as a showcase to demonstrate how ERA formation can successfully be implemented in a given area of science when several surrounding parameters converge to support implementation of this strategic concept: timely coincidence of political stimuli, responsive programming, a clearly defined--and well confined--area of research, and the readiness of the targeted research community who is well familiar with transnational cooperation at EU level. Major EU-funded malaria projects have evolved into thematic and organizational platforms that can collaborate with other global players. Europe may thus contribute more, and better, to addressing the global research agenda for malaria

  2. PREFACE: EUCAS '05: The 7th European Conference on Applied Superconductivity (Vienna University of Technology, Austria, 11 15 September 2005)

    NASA Astrophysics Data System (ADS)

    Donaldson, Gordon; Weber, Harald W.; Sauerzopf, Franz M.

    2006-03-01

    This issue of Superconductor Science and Technology contains the plenary and invited papers presented at the 7th European Conference on Applied Superconductivity (EUCAS '05) that was held at the Vienna University of Technology from 11-15 September 2005. All those contributed papers that were submitted to the Conference Proceedings will be published in the Journal of Physics: Conference Series. The scientific aims of EUCAS '05 followed the tradition established at the preceding conferences in Göttingen, Edinburgh, Eindhoven, Sitges (Barcelona), Lyngby (Copenhagen) and finally Sorrento (Napoli). The focus was placed on the interplay between the most recent developments in superconductor research and the positioning of applications of superconductivity in the marketplace. Although initially founded as an exchange forum mainly for European scientists, it has gradually developed into a truly international meeting with significant attendance from the Far East and the United States. The Vienna conference attracted 813 participants in the scientific programme and 90 accompanying persons. 59% of all participants came from Europe, 31% from the Far East, 6% from the United States and Canada as well as 4% from other nations worldwide. 27 companies presented their latest developments in the field. 32 plenary and invited lectures highlighted the state-of-the-art in the areas of materials, large-scale as well as small-scale applications; 625 contributed papers (among them 556 posters) demonstrated the broad range of exciting activities in all research areas of our field. EUCAS '05 spread a lot of optimism and enthusiasm for this fascinating field of research and for its well established technological potential, especially among the numerous young researchers attending this conference. We are grateful to all those who participated in the meeting and contributed to its success.

  3. Balancing acts: A mixed methods study of the figured world of African American 7th graders in urban science classrooms

    NASA Astrophysics Data System (ADS)

    Cleveland-Solomon, Tanya E.

    What beliefs and cultural models do youth who are underrepresented in science have about the domain of science and about themselves as science learners? What do they imagine is possible for them in relation to science both now and in the future? In other words, what constitutes their figured world of science? This dissertation study, using a mixed methods design, offers new perspectives on the ways that underrepresented youth's unexamined assumptions or cultural models and resources may shape their identities and motivation to learn science. Through analyses of survey and interview data, I found that urban African American youths' social context, gender, racial identity, and perceptions of the science they had in school influenced their motivation to learn science. Analyses of short-term classroom observations and interviews suggested that students had competing cultural models that they used in their constructions of identities as science learners, which they espoused and adopted in relation to how well they leveraged the science-related cultural resources available to them. Results from this study suggested that these 7th graders would benefit from access to more expansive cultural models through access to individuals with scientific capital as a way to allow them to create fruitful identities as science learners. If we want to ensure that students from groups that are underrepresented in science not only have better outcomes, but aspire to and enter the science career pipeline, we must also begin to support them in their negotiations of competing cultural models that limit their ability to adopt science-learner identities in their classrooms. This study endeavored to understand the particular cultural models and motivational beliefs that drive students to act, and what types of individuals they imagine scientists and science workers to be. This study also examined how cultural models and resources influence identity negotiation, specifically the roles youths

  4. Recombination-dependent growth in exonuclease-depleted recBC sbcBC strains of Escherichia coli K-12.

    PubMed

    Ryder, L; Sharples, G J; Lloyd, R G

    1996-07-01

    Analysis of the aroLM-sbcCD interval of the Escherichia coli K-12 chromosome revealed a new gene (rdgC) encoding a function required for growth in recombination-deficient recBC sbcBC strains. Deletion of rdgC does not reduce viability, conjugational recombination, or DNA repair in rec+, recA, recB, recF, or recJ mutants. However, it makes the growth of recBC sbcBC strains reliant on the RecA, RecF, and RuvC proteins and, to a large extent, on RuvAB. The recBC sbcBC delta rdgC ruvAB construct forms colonies, but cell viability is reduced to < 5%. A recBC sbcBC delta rdgC derivative carrying the temperature-sensitive recA200 allele grows at 32 degrees but not 42 degrees. Multicopy rdgC+ plasmids reduce the growth rate of recBC sbcBC strains, while multicopy sbcC+ plasmids that reactivate SbcCD nuclease cannot be maintained without RdgC protein. The data presented are interpreted to suggest that exonuclease-depleted recBC sbcBC strains have difficulty removing the displaced arm of a collapsed replication fork and that this problem is compounded in the absence of RdgC. Recombination then becomes necessary to repair the fork and allow chromosome duplication to be completed. The possibility that RdgC is an exonuclease is discussed. PMID:8807285

  5. Flux and budget of BC in the continental shelf seas adjacent to Chinese high BC emission source regions

    NASA Astrophysics Data System (ADS)

    Fang, Yin; Chen, Yingjun; Tian, Chongguo; Lin, Tian; Hu, Limin; Huang, Guopei; Tang, Jianhui; Li, Jun; Zhang, Gan

    2015-07-01

    This study conducted the first comprehensive investigation of sedimentary black carbon (BC) concentration, flux, and budget in the continental shelves of "Bohai Sea (BS) and Yellow Sea (YS)," based on measurements of BC in 191 surface sediments, 36 riverine water, and 2 seawater samples, as well as the reported data set of the atmospheric samples from seven coastal cities in the Bohai Rim. BC concentrations in these matrices were measured using the method of thermal/optical reflectance. The spatial distribution of the BC concentration in surface sediments was largely influenced by the regional hydrodynamic conditions, with high values mainly occurring in the central mud areas where fine-grained particles (median diameters > 6 Φ (i.e., <0.0156 mm)) were deposited. The BC burial flux in the BS and YS ranged from 4 to 1100 µg/cm2 yr, and averaged 166 ± 200 µg/cm2 yr, which was within the range of burial fluxes reported in other continental shelf regimes. The area-integrated sedimentary BC sink flux in the entire BS and YS was ~325 Gg/yr, and the BS alone contributed ~50% (~157 Gg/yr). The BC budget calculated in the BS showed that atmospheric deposition, riverine discharge, and import from the Northern Yellow Sea (NYS) each contributed ~51%, ~47%, and ~2%. Therefore, atmospheric deposition and riverine discharge dominated the total BC influx (~98%). Sequestration to bottom sediments was the major BC output pattern, accounting for ~88% of the input BC. Water exchange between the BS and the NYS was also an important BC transport route, with net BC transport from the BS to the NYS.

  6. Early Human Activity (pre-332 BC) in Alexandria, Egypt: New findings in Eastern Harbor Cores

    NASA Astrophysics Data System (ADS)

    Stanley, J.; Landau, E. A.

    2005-12-01

    Historians have long postulated that a settlement called Rhakotis was present on Egypt's Mediterranean coast in the area subsequently occupied by the city of Alexandria. To date, however, the precise position of that site has not been located in the immediate area of the city founded by Alexander the Great. Also undefined are the earliest phases of occupation that pre-date Alexandria on Pharos Island and in the harbour area. A geoarchaeological project emphasizing sediment cores in Alexandria's Eastern Harbour now provides evidence of human occupation adjacent to these settings prior to establishment of Greece's great port in 332 BC. A radiocarbon-dated stratigraphic unit, defined as Middle Sand (III) and older than the 4th century BC, includes locally produced ceramics, along with rock fragments of non-local origin, and increased content of sand-sized heavy mineral and organic matter. Together, these date at least to Egypt's Late Dynastic Period (712-332 BC). Moreover, the geographic positions of core sites containing these markers indicate that early habitation occurred both at Pharos Island and on the mainland where the future Alexandria would be built. New findings in cores recovered in this marine environment are adding to knowledge of both natural processes and effects of human activity in early Alexandria.

  7. A serological and histological study of the Egyptian mummy 'Iset Iri Hetes' from the Ptolemaic period III-I B.C.

    PubMed

    Kłys, M; Opolska-Bogusz, B; Próchnicka, B

    1999-01-25

    Serological and histological examinations of the muscles of the calf of an Egyptian mummy dated between the third and first centuries B.C. were performed. Human protein was identified, the ABO phenotype was determined as type B, and morphological disruption of the cells was observed. PMID:10098261

  8. Power and Limitations of Anhydrosugars to Trace Historical Natural and Anthropogenic Inputs of charcoal BC to Aquatic Systems

    NASA Astrophysics Data System (ADS)

    Louchouarn, P.; Kuo, L.; Brandenberger, J. M.; Andresen, C. S.; Kjaer, K. H.; Dalton, M.

    2011-12-01

    Plant-derived chars are the solid residues from incomplete combustion of plant materials. They are an important constituent in the black carbon (BC) continuum, an array of diverse pyrogenic organic materials ranging from slightly charred biomass (low temperature) to highly condensed refractory soot (high temperature). The characterization and quantification of plant-derived chars in environmental samples is a challenging process due to the heterogeneous nature of these substances. Most of the BC methods using oxidative approaches that seek to remove non-BC materials are limited in their potential to identify and quantify plant-derived chars because of their relative labilities compared to the condensed BC forms such as soot. Anhydrosugars, such as levoglucosan and its isomers (mannosan and galactosan), have generated considerable interest in recent years in BC research because they are exclusive thermal degradation products of cellulose/hemicellulose and are produced in different proportions in chars and smokes from low temperature combustion of different plant species permitting some source discrimination in environmental samples (e.g. softwoods vs. hardwoods; gymnosperms vs. angiosperms). We show here a synthesis of several years of work using levoglucosan in diverse environments to reconstruct local to large-scale environmental change from climate-driven wildfires to human and accidental fires. For example, in the Hood Canal (WA), the striking consistency between the fluxes of levoglucosan, the Pacific Decadal Oscillation (PDO) Index, and the Palmer Drought Severity Index (PDSI), suggests that climate oscillations may play a role in the historical wildfire activities and thus influence the inputs of char-BC to the Puget Sound. Similarly, peaks in anhydrosugars in a sediment core from Lake Copenhagen record large-scale accidental fires in the city of Copenhagen during the early and late 18th Century, and help constrain the geochronology of the core beyond the

  9. 32 CFR Appendixes B-C to Part 636 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true B Appendixes B-C to Part 636 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS MOTOR VEHICLE TRAFFIC SUPERVISION (SPECIFIC INSTALLATIONS) Appendixes B-C to Part 636...

  10. 32 CFR Appendixes B-C to Part 636 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false B Appendixes B-C to Part 636 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS MOTOR VEHICLE TRAFFIC SUPERVISION (SPECIFIC INSTALLATIONS) Appendixes B-C to Part 636...

  11. Enabling the BC Transfer System: A Discussion Paper

    ERIC Educational Resources Information Center

    British Columbia Council on Admissions and Transfer, 2011

    2011-01-01

    This discussion paper outlines processes, as well as opportunities and constraints, for "enabling" BC Transfer System institutions to enhance transfer credit information in the BC Transfer Guide, making it more reflective of institutional practices and student mobility. BCCAT's focus is increasing the availability of transfer credit information…

  12. 2005 Mobility of Transfer Students in BC. Research Results

    ERIC Educational Resources Information Center

    Holubeshen, Moufida; Cowin, Bob; Gaber, Devron

    2006-01-01

    This 8-page document outlines the key findings of research conducted to assess the number and proportion of potential transfer students from Fall 2004 who subsequently registered at BC universities in 2005, as well as the mobility patterns of these students among all public post-secondary institutions in BC. The research was initiated to assist BC…

  13. Search for the Bc meson in hadronic Z0 decays

    NASA Astrophysics Data System (ADS)

    OPAL Collaboration; Ackerstaff, K.; Alexander, G.; Allison, J.; Altekamp, N.; Anderson, K. J.; Anderson, S.; Arcelli, S.; Asai, S.; Ashby, S. F.; Axen, D.; Azuelos, G.; Ball, A. H.; Barberio, E.; Barlow, R. J.; Bartoldus, R.; Batley, J. R.; Baumann, S.; Bechtluft, J.; Beeston, C.; Behnke, T.; Bell, A. N.; Bell, K. W.; Bella, G.; Bentvelsen, S.; Bethke, S.; Betts, S.; Biebel, O.; Biguzzi, A.; Bird, S. D.; Blobel, V.; Bloodworth, I. J.; Bloomer, J. E.; Bobinski, M.; Bock, P.; Bonacorsi, D.; Boutemeur, M.; Braibant, S.; Brigliadori, L.; Brown, R. M.; Burckhart, H. J.; Burgard, C.; Bürgin, R.; Capiluppi, P.; Carnegie, R. K.; Carter, A. A.; Carter, J. R.; Chang, C. Y.; Charlton, D. G.; Chrisman, D.; Clarke, P. E. L.; Cohen, I.; Conboy, J. E.; Cooke, O. C.; Couyoumtzelis, C.; Coxe, R. L.; Cuffiani, M.; Dado, S.; Dallapiccola, C.; Dallavalle, G. M.; Davis, R.; de Jong, S.; del Pozo, L. A.; Desch, K.; Dienes, B.; Dixit, M. S.; Doucet, M.; Duchovni, E.; Duckeck, G.; Duerdoth, I. P.; Eatough, D.; Edwards, J. E. G.; Estabrooks, P. G.; Evans, H. G.; Evans, M.; Fabbri, F.; Fanfani, A.; Fanti, M.; Faust, A. A.; Feld, L.; Fiedler, F.; Fierro, M.; Fischer, H. M.; Fleck, I.; Folman, R.; Fong, D. G.; Foucher, M.; Fürtjes, A.; Futyan, D. I.; Gagnon, P.; Gary, J. W.; Gascon, J.; Gascon-Shotkin, S. M.; Geddes, N. I.; Geich-Gimbel, C.; Geralis, T.; Giacomelli, G.; Giacomelli, P.; Giacomelli, R.; Gibson, V.; Gibson, W. R.; Gingrich, D. M.; Glenzinski, D.; Goldberg, J.; Goodrick, M. J.; Gorn, W.; Grandi, C.; Gross, E.; Grunhaus, J.; Gruwé, M.; Hajdu, C.; Hanson, G. G.; Hansroul, M.; Hapke, M.; Hargrove, C. K.; Hart, P. A.; Hartmann, C.; Hauschild, M.; Hawkes, C. M.; Hawkings, R.; Hemingway, R. J.; Herndon, M.; Herten, G.; Heuer, R. D.; Hildreth, M. D.; Hill, J. C.; Hillier, S. J.; Hobson, P. R.; Hocker, A.; Homer, R. J.; Honma, A. K.; Horváth, D.; Hossain, K. R.; Howard, R.; Hüntemeyer, P.; Hutchcroft, D. E.; Igo-Kemenes, P.; Imrie, D. C.; Ingram, M. R.; Ishii, K.; Jawahery, A.; Jeffreys, P. W.; Jeremie, H.; Jimack, M.; Joly, A.; Jones, C. R.; Jones, G.; Jones, M.; Jost, U.; Jovanovic, P.; Junk, T. R.; Kanzaki, J.; Karlen, D.; Kartvelishvili, V.; Kawagoe, K.; Kawamoto, T.; Kayal, P. I.; Keeler, R. K.; Kellogg, R. G.; Kennedy, B. W.; Kirk, J.; Klier, A.; Kluth, S.; Kobayashi, T.; Kobel, M.; Koetke, D. S.; Kokott, T. P.; Kolrep, M.; Komamiya, S.; Kress, T.; Krieger, P.; von Krogh, J.; Kyberd, P.; Lafferty, G. D.; Lahmann, R.; Lai, W. P.; Lanske, D.; Lauber, J.; Lautenschlager, S. R.; Layter, J. G.; Lazic, D.; Lee, A. M.; Lefebvre, E.; Lellouch, D.; Letts, J.; Levinson, L.; Lloyd, S. L.; Loebinger, F. K.; Long, G. D.; Losty, M. J.; Ludwig, J.; Lui, D.; Macchiolo, A.; MacPherson, A.; Mannelli, M.; Marcellini, S.; Markopoulos, C.; Markus, C.; Martin, A. J.; Martin, J. P.; Martinez, G.; Mashimo, T.; Mättig, P.; McDonald, W. J.; McKenna, J.; McKigney, E. A.; McMahon, T. J.; McPherson, R. A.; Meijers, F.; Menke, S.; Merritt, F. S.; Mes, H.; Meyer, J.; Michelini, A.; Mikenberg, G.; Miller, D. J.; Mincer, A.; Mir, R.; Mohr, W.; Montanari, A.; Mori, T.; Müller, U.; Mihara, S.; Nagai, K.; Nakamura, I.; Neal, H. A.; Nellen, B.; Nisius, R.; O'Neale, S. W.; Oakham, F. G.; Odorici, F.; Ogren, H. O.; Oh, A.; Oldershaw, N. J.; Oreglia, M. J.; Orito, S.; Pálinkás, J.; Pásztor, G.; Pater, J. R.; Patrick, G. N.; Patt, J.; Perez-Ochoa, R.; Petzold, S.; Pfeifenschneider, P.; Pilcher, J. E.; Pinfold, J.; Plane, D. E.; Poffenberger, P.; Poli, B.; Posthaus, A.; Rembser, C.; Robertson, S.; Robins, S. A.; Rodning, N.; Roney, J. M.; Rooke, A.; Rossi, A. M.; Routenburg, P.; Rozen, Y.; Runge, K.; Runolfsson, O.; Ruppel, U.; Rust, D. R.; Rylko, R.; Sachs, K.; Saeki, T.; Sang, W. M.; Sarkisyan, E. K. G.; Sbarra, C.; Schaile, A. D.; Schaile, O.; Scharf, F.; Scharff-Hansen, P.; Schieck, J.; Schleper, P.; Schmitt, B.; Schmitt, S.; Schöning, A.; Schröder, M.; Schultz-Coulon, H. C.; Schumacher, M.; Schwick, C.; Scott, W. G.; Shears, T. G.; Shen, B. C.; Shepherd-Themistocleous, C. H.; Sherwood, P.; Siroli, G. P.; Sittler, A.; Skillman, A.; Skuja, A.; Smith, A. M.; Snow, G. A.; Sobie, R.; Söldner-Rembold, S.; Springer, R. W.; Sproston, M.; K. Stephens, T.; Steuerer, J.; Stockhausen, B.; Stoll, K.; Strom, D.; Ströhmer, R.; Szymanski, P.; Tafirout, R.; Talbot, S. D.; Tanaka, S.; Taras, P.; Tarem, S.; Teuscher, R.; Thiergen, M.; Thomson, M. A.; von Törne, E.; Torrence, E.; Towers, S.; Trigger, I.; Trócsányi, Z.; Tsur, E.; Turcot, A. S.; Turner-Watson, M. F.; Utzat, P.; van Kooten, R.; Verzocchi, M.; Vikas, P.; Vokurka, E. H.; Voss, H.; Wäckerle, F.; Wagner, A.; Ward, C. P.; Ward, D. R.; Watkins, P. M.; Watson, A. T.; Watson, N. K.; Wells, P. S.; Wermes, N.; White, J. S.; Wilkens, B.; Wilson, G. W.; Wilson, J. A.; Wyatt, T. R.; Yamashita, S.; Yekutieli, G.; Zacek, V.; Zer-Zion, D.

    1998-02-01

    A search for decays of the Bc meson was performed using data collected from 1990-1995 with the OPAL detector on or near the Z0 peak at LEP. The decay channels Bc+-->J/ψπ+, Bc+-->J/ψa1+ and Bc+-->J/ψl+ν were investigated, where l denotes an electron or a muon. Two candidates are observed in the mode Bc+-->J/ψπ+, with an estimated background of (0.63+/-0.20) events. The weighted mean of the masses of the two candidates is (6.32+/-0.06) GeV/c2, which is consistent with the predicted mass of the Bc meson. One candidate event is observed in the mode Bc+-->J/ψl+ν, with an estimated background of (0.82+/-0.19) events. No candidate events are observed in the Bc+-->J/ψa1+ decay mode, with an estimated background of (1.10+/-0.22) events. Upper bounds at the 90% confidence level are set on the production rates for these processes. © 1998

  14. 100-B/C Target Analyte List Development for Soil

    SciTech Connect

    R.W. Ovink

    2010-03-18

    This report documents the process used to identify source area target analytes in support of the 100-B/C remedial investigation/feasibility study addendum to DOE/RL-2008-46. This report also establishes the analyte exclusion criteria applicable for 100-B/C use and the analytical methods needed to analyze the target analytes.

  15. Mobility of Transfer Students in BC. Research Results, 2006

    ERIC Educational Resources Information Center

    Box, Dale

    2007-01-01

    In the last two years, the BC Council on Admissions and Transfer (BCCAT) has conducted research on the number of potential and eligible transfer students in colleges, university colleges, and institutes in the fall of each year and the number that enrolled in a BC public university in the subsequent year with transfer as the basis of admission.…

  16. 7th U.S. / Japan Natural Resources (UJNR) Panel on Earthquake Research: Abstract Volume and Technical Program

    USGS Publications Warehouse

    Detweiler, Shane T.; Ellsworth, William L.

    2008-01-01

    making information public in a timely manner. The Panel visited sites along the east coast of Shikoku that were inundated by the tsunami caused by the 1946 Nankai earthquake where they heard from survivors of the disaster and saw new tsunami shelters and barriers. They also visited the Median Tectonic Line, a major onshore strike-slip fault on Shikoku. The 7th Joint Panel meeting was held in Seattle, Wash., U.S.A. from October 27-30, 2008.

  17. The fall of a meteorite at Aegos Potami in 467/6 BC

    NASA Astrophysics Data System (ADS)

    Theodossiou, E. Th; Niarchos, P. G.; Manimanis, V. N.; Orchiston, W.

    2002-12-01

    Cosmic catastrophes have been associated from time to time with the fall of celestial objects to Earth. From the writings of ancient Greek authors we know that during the second year of the 78th Olympiad, that is the year corresponding to 467/6 BC, a very large meteorite fell at Aegos Potami, in the Gallipoli Peninsula (in Eastern Thrace). This event was predicted by Anaxagoras, and the meteorite was worshipped by the Cherronesites until at least the first Century AD. The fall of the Aegos Potami Meteorite was not associated with any cosmic catastrophe, but it was believed to have foretold the terminal defeat of the Athenians by the Spartans in 405 BC near Aegos Potami, which brought to an end the Peloponnesian War in favour of Sparta. In addition, according to the Latin author Pliny the Elder, during the first century AD the inhabitants of Avydus in Asia Minor worshipped another meteorite that was displayed in the city's sports centre, The fall of this meteorite is also said to have been predicted by Anaxagoras.

  18. Changing Configurations of Adult Education in Transitional Times. Conference Proceedings of the Triennial European Research Conference of the European Society for Research on the Education of Adults (ESREA) (7th, Berlin, Germany, September 4-7, 2013)

    ERIC Educational Resources Information Center

    Käpplinger, Bernd, Ed.; Lichte, Nina, Ed.; Haberzeth, Erik, Ed.; Kulmus, Claudia, Ed.

    2014-01-01

    This book assembles over 50 papers from the 7th Triennial European Research Conference of the European Society for Research on the Education of Adults (ESREA), which was held from the 4th to the 7th of September 2013 at Humboldt-University in Berlin. The title of the conference was "Changing Configurations of Adult Education in Transitional…

  19. Analysis of Neutron and Photon Detection Position for the Calibration of Plastic (BC-420) and Liquid (BC-501) Scintillators

    SciTech Connect

    Pozzi, S.A.

    2003-08-27

    This report presents the results of the neutron and photon calibration of a Bicron BC-420 plastic scintillator and a BC-501 liquid scintillator using a set of reference gamma sources and a Cf-252 source. The position of neutron and photon detection inside the scintillators as a function of energy is investigated by Monte Carlo simulation.

  20. Fullerene derivative-doped zinc oxide nanofilm as the cathode of inverted polymer solar cells with low-bandgap polymer (PTB7-Th) for high performance.

    PubMed

    Liao, Sih-Hao; Jhuo, Hong-Jyun; Cheng, Yu-Shan; Chen, Show-An

    2013-09-14

    Modification of a ZnO cathode by doping it with a hydroxyl-containing derivative - giving a ZnO-C60 cathode - provides a fullerene-derivative-rich surface and enhanced electron conduction. Inverted polymer solar cells with the ZnO-C60 cathode display markedly improved power conversion efficiency compared to those with a pristine ZnO cathode, especially when the active layer includes the low-bandgap polymer PTB7-Th. PMID:23939927

  1. [First results of participation of the Czech Republic in the 7th Framework Programme, priority Health, in years 2007-2013].

    PubMed

    Kinkorová, Judita

    2013-01-01

    European Commission has announced the first preliminary results of participation in the 7th Framework Programme (FP7), priority Health. The overview presents the basic statistics regarding the participation of the Czech teams, universities, institutions, and small and medium size enterprises (SMEs) in FP7 projects. The aim of the article is to present the basic data on the projects with the Czech participation, the EU financial contribution for Czech teams and the main research topics. PMID:24041023

  2. Recalibrating the BC Transfer System: Findings from the Consultation. Special Report, June 2007

    ERIC Educational Resources Information Center

    British Columbia Council on Admissions and Transfer, 2007

    2007-01-01

    In November 2005, the BC Council on Admissions and Transfer launched a consultation, Recalibrating the BC Transfer System, motivated by significant changes in the BC post-secondary system over the last decade and concern that these changes had not resulted in concomitant adjustments in the structure of the BC Transfer System or the BC Transfer…

  3. BC1 RNA motifs required for dendritic transport in vivo

    PubMed Central

    Robeck, Thomas; Skryabin, Boris V.; Rozhdestvensky, Timofey S.; Skryabin, Anastasiya B.; Brosius, Jürgen

    2016-01-01

    BC1 RNA is a small brain specific non-protein coding RNA. It is transported from the cell body into dendrites where it is involved in the fine-tuning translational control. Due to its compactness and established secondary structure, BC1 RNA is an ideal model for investigating the motifs necessary for dendritic localization. Previously, microinjection of in vitro transcribed BC1 RNA mutants into the soma of cultured primary neurons suggested the importance of RNA motifs for dendritic targeting. These ex vivo experiments identified a single bulged nucleotide (U22) and a putative K-turn (GA motif) structure required for dendritic localization or distal transport, respectively. We generated six transgenic mouse lines (three founders each) containing neuronally expressing BC1 RNA variants on a BC1 RNA knockout mouse background. In contrast to ex vivo data, we did not find indications of reduction or abolition of dendritic BC1 RNA localization in the mutants devoid of the GA motif or the bulged nucleotide. We confirmed the ex vivo data, which showed that the triloop terminal sequence had no consequence on dendritic transport. Interestingly, changing the triloop supporting structure completely abolished dendritic localization of BC1 RNA. We propose a novel RNA motif important for dendritic transport in vivo. PMID:27350115

  4. High Black Carbon (BC) Concentrations along Indian National Highways

    NASA Astrophysics Data System (ADS)

    Kumar, S.; Singh, A. K.; Singh, R. P.

    2015-12-01

    Abstract:Black carbon (BC), the optically absorbing component of carbonaceous aerosol, has direct influence on radiation budget and global warming. Vehicular pollution is one of the main sources for poor air quality and also atmospheric pollution. The number of diesel vehicles has increased on the Indian National Highways during day and night; these vehicles are used for the transport of goods from one city to another city and also used for public transport. A smoke plume from the vehicles is a common feature on the highways. We have made measurements of BC mass concentrations along the Indian National Highways using a potable Aethalometer installed in a moving car. We have carried out measurements along Varanasi to Kanpur (NH-2), Varanasi to Durgapur (NH-2), Varanasi to Singrauli (SH-5A) and Varanasi to Ghazipur (NH-29). We have found high concentration of BC along highways, the average BC mass concentrations vary in the range 20 - 40 µg/m3 and found high BC mass concentrations up to 600 μg/m3. Along the highways high BC concentrations were characteristics of the presence of industrial area, power plants, brick kilns and slow or standing vehicles. The effect of increasing BC concentrations along the National Highways and its impact on the vegetation and human health will be presented. Key Words: Black Carbon; Aethalometer; mass concentration; Indian National Highways.

  5. BC1 RNA motifs required for dendritic transport in vivo.

    PubMed

    Robeck, Thomas; Skryabin, Boris V; Rozhdestvensky, Timofey S; Skryabin, Anastasiya B; Brosius, Jürgen

    2016-01-01

    BC1 RNA is a small brain specific non-protein coding RNA. It is transported from the cell body into dendrites where it is involved in the fine-tuning translational control. Due to its compactness and established secondary structure, BC1 RNA is an ideal model for investigating the motifs necessary for dendritic localization. Previously, microinjection of in vitro transcribed BC1 RNA mutants into the soma of cultured primary neurons suggested the importance of RNA motifs for dendritic targeting. These ex vivo experiments identified a single bulged nucleotide (U22) and a putative K-turn (GA motif) structure required for dendritic localization or distal transport, respectively. We generated six transgenic mouse lines (three founders each) containing neuronally expressing BC1 RNA variants on a BC1 RNA knockout mouse background. In contrast to ex vivo data, we did not find indications of reduction or abolition of dendritic BC1 RNA localization in the mutants devoid of the GA motif or the bulged nucleotide. We confirmed the ex vivo data, which showed that the triloop terminal sequence had no consequence on dendritic transport. Interestingly, changing the triloop supporting structure completely abolished dendritic localization of BC1 RNA. We propose a novel RNA motif important for dendritic transport in vivo. PMID:27350115

  6. Selected papers from the 7th International Conference on Biomimetics, Artificial Muscles and Nano-bio (BAMN2013)

    NASA Astrophysics Data System (ADS)

    Shahinpoor, Mohsen; Oh, Ilkwon

    2014-07-01

    The 7th International Congress on Biomimetics, Artificial Muscles and Nano-Bio was held on the magnificent and beautiful Jeju Island in Korea on 26-30 August 2013. In June 2007, the volcanic island and lava tube cave systems were designated as UNESCO World Natural Heritage Sites for their natural beauty and unique geographical values. The aim of the congress was to offer high-level lectures, extensive discussions and communications covering the state-of-the-art on biomimetics, artificial muscles, and nano-bio technologies providing an overview of their potential applications in the industrial, biomedical, scientific and robotic fields. This conference provided a necessary platform for an ongoing dialogue between researchers from different areas (chemistry, physics, biology, medicine, engineering, robotics, etc) within biomimetics, artificial muscle and nano-bio technologies. This special issue of Smart Materials and Structures is devoted to a selected number of research papers that were presented at BAMN2013. Of the 400 or so papers and over 220 posters presented at this international congress, 15 papers were finally received, reviewed and accepted for this special issue, following the regular peer review procedures of the journal. The special issue covers polymeric artificial muscles, electroactive polymers, multifunctional nanocomposites, and their applications. In particular, electromechanical performance and other characteristics of ionic polymer-metal composites (IPMCs) fabricated with various commercially available ion exchange membranes are discussed. Additionally, the control of free-edge interlaminar stresses in composite laminates using piezoelectric actuators is elaborated on. Further, the electrode effects of a cellulose-based electroactive paper energy harvester are described. Next, a flexible tactile-feedback touch screen using transparent ferroelectric polymer film vibrators is discussed. A broad coverage of bio-applications of IPMC transducers is

  7. PREFACE: NC-AFM 2004: Proceedings of the 7th International Conference on Non-contact Atomic Force Microscopy

    NASA Astrophysics Data System (ADS)

    Schwarz, Udo

    2005-03-01

    With the ongoing miniaturization of devices and controlled nanostructuring of materials, the importance of atomic-scale information on surfaces and surface properties is growing continuously. The astonishing progress in nanoscience and nanotechnology that took place during the last two decades was in many ways related to recent progress in high-resolution imaging techniques such as scanning tunnelling microscopy and transmission electron microscopy. Since the mid-1990s, non-contact atomic force microscopy (NC-AFM) performed in ultrahigh vacuum has evolved as an alternative technique that achieves atomic resolution, but without the restriction to conducting surfaces of the previously established techniques. Advances of the rapidly developing field of NC-AFM are discussed at annual conferences as part of a series that started in 1998 in Osaka, Japan. This special issue of Nanotechnology is a compilation of original work presented at the 7th International Conference on Non-contact Atomic Force Microscopy that took place in Seattle, USA, 12-15 September 2004. Over the years, the conference grew in size and scope. Atomic resolution imaging of oxides and semiconductors remains an issue. Noticeable new developments have been presented in this regard such as, e.g., the demonstrated ability to manipulate individual atoms. Additionally, the investigation of individual molecules, clusters, and organic materials gains more and more attention. In this context, considerable effort is undertaken to transfer the NC-AFM principle based on frequency modulation to applications in air and liquids with the goal of enabling high-resolution surface studies of biological material in native environments, as well as to reduce the experimental complexity, which so far involves the availability of (costly) vacuum systems. Force spectroscopy methods continue to be improved and are applied to topics such as the imaging of the three-dimensional force field as a function of the distance with

  8. Selected papers from the 7th International Conference on Biomimetics, Artificial Muscles and Nano-bio (BAMN2013)

    NASA Astrophysics Data System (ADS)

    Shahinpoor, Mohsen; Oh, Ilkwon

    2014-07-01

    The 7th International Congress on Biomimetics, Artificial Muscles and Nano-Bio was held on the magnificent and beautiful Jeju Island in Korea on 26-30 August 2013. In June 2007, the volcanic island and lava tube cave systems were designated as UNESCO World Natural Heritage Sites for their natural beauty and unique geographical values. The aim of the congress was to offer high-level lectures, extensive discussions and communications covering the state-of-the-art on biomimetics, artificial muscles, and nano-bio technologies providing an overview of their potential applications in the industrial, biomedical, scientific and robotic fields. This conference provided a necessary platform for an ongoing dialogue between researchers from different areas (chemistry, physics, biology, medicine, engineering, robotics, etc) within biomimetics, artificial muscle and nano-bio technologies. This special issue of Smart Materials and Structures is devoted to a selected number of research papers that were presented at BAMN2013. Of the 400 or so papers and over 220 posters presented at this international congress, 15 papers were finally received, reviewed and accepted for this special issue, following the regular peer review procedures of the journal. The special issue covers polymeric artificial muscles, electroactive polymers, multifunctional nanocomposites, and their applications. In particular, electromechanical performance and other characteristics of ionic polymer-metal composites (IPMCs) fabricated with various commercially available ion exchange membranes are discussed. Additionally, the control of free-edge interlaminar stresses in composite laminates using piezoelectric actuators is elaborated on. Further, the electrode effects of a cellulose-based electroactive paper energy harvester are described. Next, a flexible tactile-feedback touch screen using transparent ferroelectric polymer film vibrators is discussed. A broad coverage of bio-applications of IPMC transducers is

  9. century drying

    NASA Astrophysics Data System (ADS)

    Cook, Benjamin I.; Smerdon, Jason E.; Seager, Richard; Coats, Sloan

    2014-11-01

    Global warming is expected to increase the frequency and intensity of droughts in the twenty-first century, but the relative contributions from changes in moisture supply (precipitation) versus evaporative demand (potential evapotranspiration; PET) have not been comprehensively assessed. Using output from a suite of general circulation model (GCM) simulations from phase 5 of the Coupled Model Intercomparison Project, projected twenty-first century drying and wetting trends are investigated using two offline indices of surface moisture balance: the Palmer Drought Severity Index (PDSI) and the Standardized Precipitation Evapotranspiration Index (SPEI). PDSI and SPEI projections using precipitation and Penman-Monteith based PET changes from the GCMs generally agree, showing robust cross-model drying in western North America, Central America, the Mediterranean, southern Africa, and the Amazon and robust wetting occurring in the Northern Hemisphere high latitudes and east Africa (PDSI only). The SPEI is more sensitive to PET changes than the PDSI, especially in arid regions such as the Sahara and Middle East. Regional drying and wetting patterns largely mirror the spatially heterogeneous response of precipitation in the models, although drying in the PDSI and SPEI calculations extends beyond the regions of reduced precipitation. This expansion of drying areas is attributed to globally widespread increases in PET, caused by increases in surface net radiation and the vapor pressure deficit. Increased PET not only intensifies drying in areas where precipitation is already reduced, it also drives areas into drought that would otherwise experience little drying or even wetting from precipitation trends alone. This PET amplification effect is largest in the Northern Hemisphere mid-latitudes, and is especially pronounced in western North America, Europe, and southeast China. Compared to PDSI projections using precipitation changes only, the projections incorporating both

  10. Effects of diatomic reagent alignment on the A + BC reaction

    NASA Technical Reports Server (NTRS)

    Pattengill, M. D.; Zare, R. N.; Jaffe, R. L.

    1987-01-01

    A computational study is reported on the A + BC - AB + C bimolecular exchange reaction in which BC is aligned with respect to the approach direction of atom A so that the initial rotational angular momentum vector of BC is either parallel (or equivalently antiparallel) or perpendicular to the initial velocity vector of A. The calculations employ a modification of the extended LEPS potential, which permits straightforward generation of noncollinear minimum energy reaction paths. The calculations clearly demonstrate that diatomic reagent alignment can markedly affect the nature of reaction product early partitioning; they also demonstrate that diatomic reagent alignment affects reactive cross sections.

  11. Production and cytogenetic analysis of BC1, BC 2, and BC 3 progenies of an intergeneric hybrid between Triticum aestivum (L.) Thell. and tetraploid Agropyron cristatum (L.) Gaertn.

    PubMed

    Chen, Q; Jahier, J; Cauderon, Y

    1992-08-01

    Intergeneric hybrids between Triticum aestivum cv 'Chinese Spring' and Agropyron cristatum 4x (2n= 5x=35, ABDPP genomes) with a high level of homoeologous meiotic pairing between the wheat chromosomes were backcrossed 3 times to wheat. Pollination of the F1 hybrid with 'Chinese Spring' resulted in 22 BC1 seeds with an average seed set of 1.52%. Five BC1 plants with 39-41 chromosomes were raised using embryo rescue techniques. Chromosome pairing in the BC1 was characterized by a high frequency of multivalent associations, but in spite of this there was no evidence of homoeologous pairing between chromosomes of wheat and those of Agropyron. All of the plants were self sterile. The embryo rescue technique was again essential to produce 39 BC2 plants with chromosome numbers ranging from 37 to 67. The phenomenon of meiotic non-reduction was also observed in the BC3 progenies. In this generation male and female fertility greatly increased, and meiotic pairing was fairly regular. Some monosomic (2n=43) and double monosomic (2n=44) lines were produced. Analysis of these progenies should permit the extraction of the seven possible wheat-Agropyron disomic addition lines including those with the added chromosomes carrying the genes involved in meiotic non-reduction and in suppression of Ph activity. PMID:24201360

  12. Temporal and spatial dynamics of human immunodeficiency virus type 1 circulating recombinant forms 08_BC and 07_BC in Asia.

    PubMed

    Tee, Kok Keng; Pybus, Oliver G; Li, Xiao-Jie; Han, Xiaoxu; Shang, Hong; Kamarulzaman, Adeeba; Takebe, Yutaka

    2008-09-01

    Human immunodeficiency virus type 1 (HIV-1) CRF08_BC and CRF07_BC are two major recombinants descended from subtypes B' and C. Despite their massive epidemic impact in China, their migration patterns and divergence times remain unknown. Phylogenetic and population genetic analyses were performed on 228 HIV-1 sequences representing CRF08_BC, CRF07_BC, and subtype C strains from different locations across China, India, and Myanmar. Genome-specific rates of evolution and divergence times were estimated using a Bayesian Markov chain Monte Carlo framework under various evolutionary models. CRF08_BC originated in 1990.3 (95% credible region [CR], 1988.6 to 1991.9) in Yunnan province before spreading to Guangxi (south) and Liaoning (northeast) around 1995. Inside Guangxi region, the eastward expansion of CRF08_BC continued from Baise city (west) to Binyang (central) between 1997 and 1998 and later spread into Pingxiang around 1999 in the south, mainly through injecting drug users. Additionally, CRF07_BC diverged from its common ancestor in 1993.3 (95% CR, 1991.2 to 1995.2) before crossing the border into southern Taiwan in late 1990s. Phylogenetic analysis indicates that both CRF08_BC and CRF07_BC can trace their origins to Yunnan. The parental Indian subtype C lineage likely entered China around 1981.2 (95% CR, 1976.7 to 1985.9). Using a multiple unlinked locus model, we also showed that the dates of divergence calculated in this study may not be significantly affected by intrasubtype recombination among different lineages. This is the first phylodynamic study depicting the spatiotemporal dynamics of HIV/AIDS in East Asia. PMID:18596096

  13. First-principles study of half-metallicity in semi-hydrogenated BC3, BC5, BC7, and B-doped graphone sheets

    PubMed Central

    2011-01-01

    Using first principles calculations, we investigate the electronic structures of semi-hydrogenated BC3, BC5, BC7, and B-doped graphone sheets. We find that all the semi-hydrogenated boron-carbon sheets exhibit half-metallic behaviors. The magnetism originates from the non-bonding pz orbitals of carbon atoms, which cause the flat bands to satisfy the Stoner criterion. On the other hand, boron atoms weaken the magnetic moments of nearby carbon atoms and act as holes doped in the sheets. It induces the down shift of the Fermi level and the half-metallicity in semi-hydrogenated sheets. Our studies demonstrate that the semi-hydrogenation is an effective route to achieve half-metallicity in the boron-carbon systems. PMID:21711690

  14. 7. (lr) Arches DE, CD, BC. View southwest Ashton ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. (l-r) Arches D-E, C-D, B-C. View southwest - Ashton Viaduct, State Route 116 (Washington Highway) spanning Blackstone River, Blackstone Canal, & Providence & Worcester Railroad, Ashton, Providence County, RI

  15. 5. Railroad tracks, (lr) arches EF, DE, CD, BC. View ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Railroad tracks, (l-r) arches E-F, D-E, C-D, B-C. View southwest - Ashton Viaduct, State Route 116 (Washington Highway) spanning Blackstone River, Blackstone Canal, & Providence & Worcester Railroad, Ashton, Providence County, RI

  16. BC Transit Fuel Cell Bus Project: Evaluation Results Report

    SciTech Connect

    Eudy, L.; Post, M.

    2014-02-01

    This report evaluates a fuel cell electric bus demonstration led by British Columbia Transit (BC Transit) in Whistler, Canada. BC Transit is collaborating with the California Air Resources Board and the U.S. Department of Energy's National Renewable Energy Laboratory to evaluate the buses in revenue service. This evaluation report covers two years of revenue service data on the buses from April 2011 through March 2013.

  17. Proceedings of the 7th International Meeting on Nuclear Reactor Thermal-Hydraulics NURETH-7. Volume 1, Sessions 1-5

    SciTech Connect

    Block, R.C.; Feiner, F.

    1995-09-01

    This document, Volume 1, includes papers presented at the 7th International Meeting on Nuclear Reactor Thermal-Hydraulics (NURETH-7) September 10--15, 1995 at Saratoga Springs, N.Y. The following subjects are discussed: Progress in analytical and experimental work on the fundamentals of nuclear thermal-hydraulics, the development of advanced mathematical and numerical methods, and the application of advancements in the field in the development of novel reactor concepts. Also combined issues of thermal-hydraulics and reactor/power-plant safety, core neutronics and/or radiation. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

  18. Coupled Aerosol-Chemistry-Climate Twentieth-Century Transient Model Investigation: Trends in Short-Lived Species and Climate Responses

    NASA Technical Reports Server (NTRS)

    Koch, Dorothy; Bauer, Susanne E.; Del Genio, Anthony; Faluvegi, Greg; McConnell, Joseph R.; Menon, Surabi; Miller, Ronald L.; Rind, David; Ruedy, Reto; Schmidt, Gavin A.; Shindell, Drew

    2011-01-01

    The authors simulate transient twentieth-century climate in the Goddard Institute for Space Studies (GISS) GCM, with aerosol and ozone chemistry fully coupled to one another and to climate including a full dynamic ocean. Aerosols include sulfate, black carbon (BC), organic carbon, nitrate, sea salt, and dust. Direct and BC snow-albedo radiative effects are included. Model BC and sulfur trends agree fairly well with records from Greenland and European ice cores and with sulfur deposition in North America; however, the model underestimates the sulfur decline at the end of the century in Greenland. Global BC effects peak early in the century (1940s); afterward the BC effects decrease at high latitudes of the Northern Hemisphere but continue to increase at lower latitudes. The largest increase in aerosol optical depth occurs in the middle of the century (1940s-80s) when sulfate forcing peaks and causes global dimming. After this, aerosols decrease in eastern North America and northern Eurasia leading to regional positive forcing changes and brightening. These surface forcing changes have the correct trend but are too weak. Over the century, the net aerosol direct effect is -0.41 Watts per square meter, the BC-albedo effect is -0.02 Watts per square meter, and the net ozone forcing is +0.24 Watts per square meter. The model polar stratospheric ozone depletion develops, beginning in the 1970s. Concurrently, the sea salt load and negative radiative flux increase over the oceans around Antarctica. Net warming over the century is modeled fairly well; however, the model fails to capture the dynamics of the observedmidcentury cooling followed by the late century warming.Over the century, 20% of Arctic warming and snow ice cover loss is attributed to the BC albedo effect. However, the decrease in this effect at the end of the century contributes to Arctic cooling. To test the climate responses to sulfate and BC pollution, two experiments were branched from 1970 that removed

  19. Characterization of Chromosome Inheritance of the Intergeneric BC2 and BC3 Progeny between Saccharum spp. and Erianthus arundinaceus

    PubMed Central

    Wang, Ping; Lin, Yanquan; Fu, Cheng; Deng, Zuhu; Wang, Qinnan; Li, Qiwei; Chen, Rukai; Zhang, Muqing

    2015-01-01

    Erianthus arundinaceus (E. arundinaceus) has many desirable agronomic traits for sugarcane improvement, such as high biomass, vigor, rationing ability, tolerance to drought, and water logging, as well as resistance to pests and disease. To investigate the introgression of the E. arundinaceus genome into sugarcane in the higher generations, intergeneric BC2 and BC3 progeny generated between Saccharum spp. and E. arundinaceus were studied using the genomic in situ hybridization (GISH) technique. The results showed that the BC2 and BC3 generations resulted from n + n chromosome transmission. Furthermore, chromosome translocation occurred at terminal fragments from the E. arundinaceus chromosome in some progeny of Saccharum spp. and E. arundinaceus. Notably, the translocated chromosomes could be stably transmitted to their progeny. This study illustrates the characterization of chromosome inheritance of the intergeneric BC2 and BC3 progeny between Saccharum spp. and E. arundinaceus. This work could provide more useful molecular cytogenetic information for the germplasm resources of E. arundinaceus, and may promote further understanding of the germplasm resources of E. arundinaceus for sugarcane breeders to accelerate its progress in sugarcane commercial breeding. PMID:26196281

  20. Characterization of Chromosome Inheritance of the Intergeneric BC2 and BC3 Progeny between Saccharum spp. and Erianthus arundinaceus.

    PubMed

    Huang, Yongji; Wu, Jiayun; Wang, Ping; Lin, Yanquan; Fu, Cheng; Deng, Zuhu; Wang, Qinnan; Li, Qiwei; Chen, Rukai; Zhang, Muqing

    2015-01-01

    Erianthus arundinaceus (E. arundinaceus) has many desirable agronomic traits for sugarcane improvement, such as high biomass, vigor, rationing ability, tolerance to drought, and water logging, as well as resistance to pests and disease. To investigate the introgression of the E. arundinaceus genome into sugarcane in the higher generations, intergeneric BC2 and BC3 progeny generated between Saccharum spp. and E. arundinaceus were studied using the genomic in situ hybridization (GISH) technique. The results showed that the BC2 and BC3 generations resulted from n + n chromosome transmission. Furthermore, chromosome translocation occurred at terminal fragments from the E. arundinaceus chromosome in some progeny of Saccharum spp. and E. arundinaceus. Notably, the translocated chromosomes could be stably transmitted to their progeny. This study illustrates the characterization of chromosome inheritance of the intergeneric BC2 and BC3 progeny between Saccharum spp. and E. arundinaceus. This work could provide more useful molecular cytogenetic information for the germplasm resources of E. arundinaceus, and may promote further understanding of the germplasm resources of E. arundinaceus for sugarcane breeders to accelerate its progress in sugarcane commercial breeding. PMID:26196281

  1. Santorini eruption radiocarbon dated to 1627-1600 B.C.

    PubMed

    Friedrich, Walter L; Kromer, Bernd; Friedrich, Michael; Heinemeier, Jan; Pfeiffer, Tom; Talamo, Sahra

    2006-04-28

    Precise and direct dating of the Minoan eruption of Santorini (Thera) in Greece, a global Bronze Age time marker, has been made possible by the unique find of an olive tree, buried alive in life position by the tephra (pumice and ashes) on Santorini. We applied so-called radiocarbon wiggle-matching to a carbon-14 sequence of tree-ring segments to constrain the eruption date to the range 1627-1600 B.C. with 95.4% probability. Our result is in the range of previous, less precise, and less direct results of several scientific dating methods, but it is a century earlier than the date derived from traditional Egyptian chronologies. PMID:16645088

  2. Effects of pubertal timing on deviant behaviors in Taiwan: A longitudinal analysis of 7th- to 12th-grade adolescents.

    PubMed

    Tsai, Meng-Che; Strong, Carol; Lin, Chung-Ying

    2015-07-01

    We investigated the relationship between pubertal timing and deviant behaviors in Taiwan using Taiwan Youth Project (TYP) data. The TYP used multistage-stratified and class-clustered methods in 40 randomly selected schools. We analyzed 1541 adolescents (770 boys; 50.0%) who self-reported their deviant behaviors in 7th, 8th, 10th, and 12th grades. Participants were assigned to early- (n = 244; 15.8%), on-time- (n = 992; 64.4%), and late- (n = 305; 19.8%) puberty groups, and one-way analysis of variance and latent growth modeling were used to examine the frequency of deviant behaviors between them. Early-puberty adolescents had more deviant behaviors (mean = 0.43, SD = 0.74) than did late-puberty adolescents during 7th grade (mean = 0.27, SD = 0.59; p = 0.004), but not after 8th grade. There were no significant differences in the deviance level between on-time-puberty and early- and late-puberty adolescents. Moreover, puberty was not correlated with the growth of deviant behaviors, which decreased with age. However, boys seemed to engage in more deviant behaviors at the beginning, but their engagement seemed to decline faster than it did for girls. In sum, the deviance of early-puberty adolescents seemed to diminish as they got older. PMID:25956430

  3. Comparison of Values in 5th, 6th, 7th and 8th Grade Primary Education Music Class Students'? Workbooks According to Rokeach?s and Akbas's Value Classifications

    ERIC Educational Resources Information Center

    Çakirer, H. Serdar

    2014-01-01

    The aim of the present study is to compare the values in the songs of 5th, 6th, 7th and 8th grade primary education music classes students? workbooks according to the value categorizations proposed by Rockeach and Akbas and which values among the categories mentioned are taught to the students in the 5th, 6th, 7th and 8th grade primary education…

  4. B.C. Hydro-IPC review: Interim report

    SciTech Connect

    1996-12-31

    This report is a review of the activities surrounding the creation of IPC (International Power Corporation) and its joint venture with the British Columbia Hydro and Power Authority (BC Hydro) for the development of international power projects, including the Raiwind project in Pakistan. The scope of the review included determination of: The process followed in establishing IPC and the structure of corporations associated with the Raiwind project; the process of conducting the IPC share offering; whether the conduct of participants was in accordance with sound public policy and good business practice; what guidelines and checks existed to protect the public interest; and whether there were any system or governance failures either inside or outside BC Hydro. Sections of the review examine the offshore economic development strategies of BC Hydro; the nature and scope of the Raiwind project; the principal participants involved in that project; the choice of a Cayman Islands planning structure; the investment of BC Hydro funds in the project; the private sector component of Raiwind project funding; accounting for funds invested; standards of conduct of government and BC Hydro-related personnel, including conflicts of interest; and governance issues.

  5. Democritus (460-370 BC) on embryology, anatomy and pediatrics: the unknown aspects of the Greek atomic scientist.

    PubMed

    Tsoucalas, Gregory; Karamanou, Marianna; Kousoulis, Antonis A; Androutsos, George

    2012-01-01

    Democritus was born in Abdera, Thrace, in the 5th century BC. He travelled to the East while being the student of famous philosophers. His philosophical ideas and the establishment of particles, "the atoms", gave him a leading position in world history. However, his medical knowledge was vast especially in the field of pediatric pharmacology. Numerous are also the reports of his passion for anatomy. Democritus' views regarding the issue of Human Nature and Anatomy are depicted in a letter he sent to Hippocrates of Kos. He died in old age, possibly of infection after having totally neglected his personal hygiene. PMID:23420949

  6. Synthesis and Characterization of Bulk BC8 Si

    NASA Astrophysics Data System (ADS)

    Zhang, Haidong; Strobel, Timothy

    Silicon, an essential element for modern industry, has several allotropes existing at ambient conditions. Among them, one of the most important phases is the metastable Si-III (BC8) structure. Although it has been known since 1960s, experimental characterization of its properties is still rare primarily due to lack of large bulk samples. Common methods produce BC8 Si samples with the size of micrometers in dimension, preventing definitive experimental measurements. In this work we report synthesis of phase pure bulk BC8 Si with the size of a few millimeters through the multi-anvil press method. The structure was confirmed by powder X-ray diffraction and further supported by the Raman spectrum. Its electrical resistance exhibits clear temperature dependence, increasing from 300 K to 2K. A crossover region occurs around 80 K to 100 K, showing a stronger dependence below 80 K. We also report its optical properties, thermal stability and phonon density of states.

  7. Hydrogen storage in polylithiated BC3 monolayer sheet

    NASA Astrophysics Data System (ADS)

    Li, Yunguo; Hussain, Tanveer; De Sarkar, Abir; Ahuja, Rajeev

    2013-09-01

    We perform a detailed study on the stability, electronic structure and hydrogen storage capacity of polylithiated (CLi3 functionalized) boron carbide (BC3) monolayer sheet using first-principles calculations. The binding of the CLi3 radical to the boron carbide (BC3) monolayer sheet is found to be large enough to ensure its uniform distribution without any clustering. The structural stability has been confirmed by molecular dynamics. Each lithium atom is able to accommodate 4 H2 molecules with an average binding energy of 0.21 eV, which is suitable for reversible H2 adsorption/desorption at ambient temperatures. The uptake of H2 is found to reach up to 9.83 wt% in polylithiated BC3 monolayer sheet.

  8. BC Transit Fuel Cell Bus Project Evaluation Results: Second Report

    SciTech Connect

    Eudy, L.; Post, M.

    2014-09-01

    Second report evaluating a fuel cell electric bus (FCEB) demonstration led by British Columbia Transit (BC Transit) in Whistler, Canada. BC Transit is collaborating with the California Air Resources Board and the U.S. Department of Energy's National Renewable Energy Laboratory to evaluate the buses in revenue service. NREL published its first report on the demonstration in February 2014. This report is an update to the previous report; it covers 3 full years of revenue service data on the buses from April 2011 through March 2014 and focuses on the final experiences and lessons learned.

  9. Plume Delineation in the BC Cribs and Trenches Area

    SciTech Connect

    Rucker, Dale F.; Sweeney, Mark D.

    2004-11-30

    HydroGEOPHYSICS, Inc. and Pacific Northwest National Laboratory (PNNL) were contracted by Fluor Hanford Group, Inc. to conduct a geophysical investigation in the area of the BC Cribs and Trenches (subject site) at the Hanford Site in Richland, Washington. The BC Cribs and Trenches are located south of the 200 East Area. This document provides the details of the investigation to identify existing infrastructure from legacy disposal activities and to delineate the edges of a groundwater plume that contains radiological and heavy metal constituents beneath the 216-B-26 and 216-B-52 Trenches, and the 216-B-14 through 216-B-19 Cribs.

  10. Measurement of the lifetime of the Bc+ meson using the Bc+ → J / ψπ+ decay mode

    NASA Astrophysics Data System (ADS)

    Aaij, R.; Adeva, B.; Adinolfi, M.; Affolder, A.; Ajaltouni, Z.; Akar, S.; Albrecht, J.; Alessio, F.; Alexander, M.; Ali, S.; Alkhazov, G.; Alvarez Cartelle, P.; Alves, A. A.; Amato, S.; Amerio, S.; Amhis, Y.; An, L.; Anderlini, L.; Anderson, J.; Andreassen, R.; Andreotti, M.; Andrews, J. E.; Appleby, R. B.; Aquines Gutierrez, O.; Archilli, F.; Artamonov, A.; Artuso, M.; Aslanides, E.; Auriemma, G.; Baalouch, M.; Bachmann, S.; Back, J. J.; Badalov, A.; Baesso, C.; Baldini, W.; Barlow, R. J.; Barschel, C.; Barsuk, S.; Barter, W.; Batozskaya, V.; Battista, V.; Bay, A.; Beaucourt, L.; Beddow, J.; Bedeschi, F.; Bediaga, I.; Belogurov, S.; Belous, K.; Belyaev, I.; Ben-Haim, E.; Bencivenni, G.; Benson, S.; Benton, J.; Berezhnoy, A.; Bernet, R.; Bertolin, A.; Bettler, M.-O.; van Beuzekom, M.; Bien, A.; Bifani, S.; Bird, T.; Bizzeti, A.; Bjørnstad, P. M.; Blake, T.; Blanc, F.; Blouw, J.; Blusk, S.; Bocci, V.; Bondar, A.; Bondar, N.; Bonivento, W.; Borghi, S.; Borgia, A.; Borsato, M.; Bowcock, T. J. V.; Bowen, E.; Bozzi, C.; Brett, D.; Britsch, M.; Britton, T.; Brodzicka, J.; Brook, N. H.; Bursche, A.; Buytaert, J.; Cadeddu, S.; Calabrese, R.; Calvi, M.; Calvo Gomez, M.; Campana, P.; Campora Perez, D.; Capriotti, L.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carson, L.; Carvalho Akiba, K.; Casanova Mohr, R. C. M.; Casse, G.; Cassina, L.; Castillo Garcia, L.; Cattaneo, M.; Cauet, Ch.; Cenci, R.; Charles, M.; Charpentier, Ph.; Chefdeville, M.; Chen, S.; Cheung, S.-F.; Chiapolini, N.; Chrzaszcz, M.; Cid Vidal, X.; Ciezarek, G.; Clarke, P. E. L.; Clemencic, M.; Cliff, H. V.; Closier, J.; Coco, V.; Cogan, J.; Cogneras, E.; Cogoni, V.; Cojocariu, L.; Collazuol, G.; Collins, P.; Comerma-Montells, A.; Contu, A.; Cook, A.; Coombes, M.; Coquereau, S.; Corti, G.; Corvo, M.; Counts, I.; Couturier, B.; Cowan, G. A.; Craik, D. C.; Crocombe, A. C.; Cruz Torres, M.; Cunliffe, S.; Currie, R.; D'Ambrosio, C.; Dalseno, J.; David, P.; David, P. N. Y.; Davis, A.; De Bruyn, K.; De Capua, S.; De Cian, M.; De Miranda, J. M.; De Paula, L.; De Silva, W.; De Simone, P.; Dean, C.-T.; Decamp, D.; Deckenhoff, M.; Del Buono, L.; Déléage, N.; Derkach, D.; Deschamps, O.; Dettori, F.; Dey, B.; Di Canto, A.; Di Domenico, A.; Dijkstra, H.; Donleavy, S.; Dordei, F.; Dorigo, M.; Dosil Suárez, A.; Dossett, D.; Dovbnya, A.; Dreimanis, K.; Dujany, G.; Dupertuis, F.; Durante, P.; Dzhelyadin, R.; Dziurda, A.; Dzyuba, A.; Easo, S.; Egede, U.; Egorychev, V.; Eidelman, S.; Eisenhardt, S.; Eitschberger, U.; Ekelhof, R.; Eklund, L.; El Rifai, I.; Elsasser, Ch.; Ely, S.; Esen, S.; Evans, H. M.; Evans, T.; Falabella, A.; Färber, C.; Farinelli, C.; Farley, N.; Farry, S.; Fay, R.; Ferguson, D.; Fernandez Albor, V.; Ferreira Rodrigues, F.; Ferro-Luzzi, M.; Filippov, S.; Fiore, M.; Fiorini, M.; Firlej, M.; Fitzpatrick, C.; Fiutowski, T.; Fol, P.; Fontana, M.; Fontanelli, F.; Forty, R.; Francisco, O.; Frank, M.; Frei, C.; Frosini, M.; Fu, J.; Furfaro, E.; Gallas Torreira, A.; Galli, D.; Gallorini, S.; Gambetta, S.; Gandelman, M.; Gandini, P.; Gao, Y.; García Pardiñas, J.; Garofoli, J.; Garra Tico, J.; Garrido, L.; Gascon, D.; Gaspar, C.; Gastaldi, U.; Gauld, R.; Gavardi, L.; Gazzoni, G.; Geraci, A.; Gersabeck, E.; Gersabeck, M.; Gershon, T.; Ghez, Ph.; Gianelle, A.; Gianì, S.; Gibson, V.; Giubega, L.; Gligorov, V. V.; Göbel, C.; Golubkov, D.; Golutvin, A.; Gomes, A.; Gotti, C.; Grabalosa Gándara, M.; Graciani Diaz, R.; Granado Cardoso, L. A.; Graugés, E.; Graverini, E.; Graziani, G.; Grecu, A.; Greening, E.; Gregson, S.; Griffith, P.; Grillo, L.; Grünberg, O.; Gui, B.; Gushchin, E.; Guz, Yu.; Gys, T.; Hadjivasiliou, C.; Haefeli, G.; Haen, C.; Haines, S. C.; Hall, S.; Hamilton, B.; Hampson, T.; Han, X.; Hansmann-Menzemer, S.; Harnew, N.; Harnew, S. T.; Harrison, J.; He, J.; Head, T.; Heijne, V.; Hennessy, K.; Henrard, P.; Henry, L.; Hernando Morata, J. A.; van Herwijnen, E.; Heß, M.; Hicheur, A.; Hill, D.; Hoballah, M.; Hombach, C.; Hulsbergen, W.; Hussain, N.; Hutchcroft, D.; Hynds, D.; Idzik, M.; Ilten, P.; Jacobsson, R.; Jaeger, A.; Jalocha, J.; Jans, E.; Jaton, P.; Jawahery, A.; Jing, F.; John, M.; Johnson, D.; Jones, C. R.; Joram, C.; Jost, B.; Jurik, N.; Kandybei, S.; Kanso, W.; Karacson, M.; Karbach, T. M.; Karodia, S.; Kelsey, M.; Kenyon, I. R.; Ketel, T.; Khanji, B.; Khurewathanakul, C.; Klaver, S.; Klimaszewski, K.; Kochebina, O.; Kolpin, M.; Komarov, I.; Koopman, R. F.; Koppenburg, P.; Korolev, M.; Kravchuk, L.; Kreplin, K.; Kreps, M.; Krocker, G.; Krokovny, P.; Kruse, F.; Kucewicz, W.; Kucharczyk, M.; Kudryavtsev, V.; Kurek, K.; Kvaratskheliya, T.; La Thi, V. N.; Lacarrere, D.; Lafferty, G.; Lai, A.; Lambert, D.; Lambert, R. W.; Lanfranchi, G.; Langenbruch, C.; Langhans, B.; Latham, T.; Lazzeroni, C.; Le Gac, R.; van Leerdam, J.; Lees, J.-P.; Lefèvre, R.; Leflat, A.; Lefrançois, J.; Leroy, O.; Lesiak, T.; Leverington, B.; Li, Y.; Likhomanenko, T.; Liles, M.; Lindner, R.; Linn, C.; Lionetto, F.; Liu, B.; Lohn, S.; Longstaff, I.; Lopes, J. H.; Lowdon, P.; Lucchesi, D.; Luo, H.; Lupato, A.; Luppi, E.; Lupton, O.; Machefert, F.; Machikhiliyan, I. V.; Maciuc, F.; Maev, O.; Malde, S.; Malinin, A.; Manca, G.; Mancinelli, G.; Mapelli, A.; Maratas, J.; Marchand, J. F.; Marconi, U.; Marin Benito, C.; Marino, P.; Märki, R.; Marks, J.; Martellotti, G.; Martinelli, M.; Martinez Santos, D.; Martinez Vidal, F.; Martins Tostes, D.; Massafferri, A.; Matev, R.; Mathe, Z.; Matteuzzi, C.; Mazurov, A.; McCann, M.; McCarthy, J.; McNab, A.; McNulty, R.; McSkelly, B.; Meadows, B.; Meier, F.; Meissner, M.; Merk, M.; Milanes, D. A.; Minard, M.-N.; Moggi, N.; Molina Rodriguez, J.; Monteil, S.; Morandin, M.; Morawski, P.; Mordà, A.; Morello, M. J.; Moron, J.; Morris, A.-B.; Mountain, R.; Muheim, F.; Müller, K.; Mussini, M.; Muster, B.; Naik, P.; Nakada, T.; Nandakumar, R.; Nasteva, I.; Needham, M.; Neri, N.; Neubert, S.; Neufeld, N.; Neuner, M.; Nguyen, A. D.; Nguyen, T. D.; Nguyen-Mau, C.; Nicol, M.; Niess, V.; Niet, R.; Nikitin, N.; Nikodem, T.; Novoselov, A.; O'Hanlon, D. P.; Oblakowska-Mucha, A.; Obraztsov, V.; Ogilvy, S.; Okhrimenko, O.; Oldeman, R.; Onderwater, C. J. G.; Orlandea, M.; Otalora Goicochea, J. M.; Otto, A.; Owen, P.; Oyanguren, A.; Pal, B. K.; Palano, A.; Palombo, F.; Palutan, M.; Panman, J.; Papanestis, A.; Pappagallo, M.; Pappalardo, L. L.; Parkes, C.; Parkinson, C. J.; Passaleva, G.; Patel, G. D.; Patel, M.; Patrignani, C.; Pearce, A.; Pellegrino, A.; Penso, G.; Pepe Altarelli, M.; Perazzini, S.; Perret, P.; Pescatore, L.; Pesen, E.; Petridis, K.; Petrolini, A.; Picatoste Olloqui, E.; Pietrzyk, B.; Pilař, T.; Pinci, D.; Pistone, A.; Playfer, S.; Plo Casasus, M.; Polci, F.; Poluektov, A.; Polyakov, I.; Polycarpo, E.; Popov, A.; Popov, D.; Popovici, B.; Potterat, C.; Price, E.; Price, J. D.; Prisciandaro, J.; Pritchard, A.; Prouve, C.; Pugatch, V.; Puig Navarro, A.; Punzi, G.; Qian, W.; Rachwal, B.; Rademacker, J. H.; Rakotomiaramanana, B.; Rama, M.; Rangel, M. S.; Raniuk, I.; Rauschmayr, N.; Raven, G.; Redi, F.; Reichert, S.; Reid, M. M.; dos Reis, A. C.; Ricciardi, S.; Richards, S.; Rihl, M.; Rinnert, K.; Rives Molina, V.; Robbe, P.; Rodrigues, A. B.; Rodrigues, E.; Rodriguez Perez, P.; Roiser, S.; Romanovsky, V.; Romero Vidal, A.; Rotondo, M.; Rouvinet, J.; Ruf, T.; Ruiz, H.; Ruiz Valls, P.; Saborido Silva, J. J.; Sagidova, N.; Sail, P.; Saitta, B.; Salustino Guimaraes, V.; Sanchez Mayordomo, C.; Sanmartin Sedes, B.; Santacesaria, R.; Santamarina Rios, C.; Santovetti, E.; Sarti, A.; Satriano, C.; Satta, A.; Saunders, D. M.; Savrina, D.; Schiller, M.; Schindler, H.; Schlupp, M.; Schmelling, M.; Schmidt, B.; Schneider, O.; Schopper, A.; Schune, M.-H.; Schwemmer, R.; Sciascia, B.; Sciubba, A.; Semennikov, A.; Sepp, I.; Serra, N.; Serrano, J.; Sestini, L.; Seyfert, P.; Shapkin, M.; Shapoval, I.; Shcheglov, Y.; Shears, T.; Shekhtman, L.; Shevchenko, V.; Shires, A.; Silva Coutinho, R.; Simi, G.; Sirendi, M.; Skidmore, N.; Skillicorn, I.; Skwarnicki, T.; Smith, N. A.; Smith, E.; Smith, E.; Smith, J.; Smith, M.; Snoek, H.; Sokoloff, M. D.; Soler, F. J. P.; Soomro, F.; Souza, D.; Souza De Paula, B.; Spaan, B.; Spradlin, P.; Sridharan, S.; Stagni, F.; Stahl, M.; Stahl, S.; Steinkamp, O.; Stenyakin, O.; Sterpka, F.; Stevenson, S.; Stoica, S.; Stone, S.; Storaci, B.; Stracka, S.; Straticiuc, M.; Straumann, U.; Stroili, R.; Sun, L.; Sutcliffe, W.; Swientek, K.; Swientek, S.; Syropoulos, V.; Szczekowski, M.; Szczypka, P.; Szumlak, T.; T'Jampens, S.; Teklishyn, M.; Tellarini, G.; Teubert, F.; Thomas, C.; Thomas, E.; van Tilburg, J.; Tisserand, V.; Tobin, M.; Todd, J.; Tolk, S.; Tomassetti, L.; Tonelli, D.; Topp-Joergensen, S.; Torr, N.; Tournefier, E.; Tourneur, S.; Tran, M. T.; Tresch, M.; Trisovic, A.; Tsaregorodtsev, A.; Tsopelas, P.; Tuning, N.; Ubeda Garcia, M.; Ukleja, A.; Ustyuzhanin, A.; Uwer, U.; Vacca, C.; Vagnoni, V.; Valenti, G.; Vallier, A.; Vazquez Gomez, R.; Vazquez Regueiro, P.; Vázquez Sierra, C.; Vecchi, S.; Velthuis, J. J.; Veltri, M.; Veneziano, G.; Vesterinen, M.; Viana Barbosa, J. V.; Viaud, B.; Vieira, D.; Vieites Diaz, M.; Vilasis-Cardona, X.; Vollhardt, A.; Volyanskyy, D.; Voong, D.; Vorobyev, A.; Vorobyev, V.; Voß, C.; de Vries, J. A.; Waldi, R.; Wallace, C.; Wallace, R.; Walsh, J.; Wandernoth, S.; Wang, J.; Ward, D. R.; Watson, N. K.; Websdale, D.; Whitehead, M.; Wiedner, D.; Wilkinson, G.; Wilkinson, M.; Williams, M. P.; Williams, M.; Wilschut, H. W.; Wilson, F. F.; Wimberley, J.; Wishahi, J.; Wislicki, W.; Witek, M.; Wormser, G.; Wotton, S. A.; Wright, S.; Wyllie, K.; Xie, Y.; Xing, Z.; Xu, Z.; Yang, Z.; Yuan, X.; Yushchenko, O.; Zangoli, M.; Zavertyaev, M.; Zhang, L.; Zhang, W. C.; Zhang, Y.; Zhelezov, A.; Zhokhov, A.; Zhong, L.

    2015-03-01

    The difference in total widths between the Bc+  and B+ mesons is measured using a data sample corresponding to an integrated luminosity of 3.0fb-1  collected by the LHCb experiment in 7 and 8 TeV centre-of-mass energy proton-proton collisions at the LHC. Through the study of the time evolution of Bc+ → J / ψπ+ and B+ → J / ψK+ decays, the width difference is measured to be

  11. Improving the BC Transfer Experience: Feedback from Students. Research Results

    ERIC Educational Resources Information Center

    British Columbia Council on Admissions and Transfer, 2012

    2012-01-01

    The BC Council on Admissions and Transfer is always seeking ways to improve the transfer system for the benefit of students. Doing so is often informed by research in one form or another. Questions were added to the 2011 Diploma, Associate Degree, and Certificate Student Outcomes (DACSO) survey to help us gain a better understanding of why some…

  12. Improving the BC Transfer Experience: Feedback from Students

    ERIC Educational Resources Information Center

    British Columbia Council on Admissions and Transfer, 2012

    2012-01-01

    The BC Council on Admissions and Transfer is always seeking ways to improve the transfer system for the benefit of students. Doing so is informed by research in one form or another. Questions added to the 2011 Diploma, Associate Degree and Certificate Student Outcomes (DACSO) survey sought to gain a better understanding of why some students are…

  13. Bethe Ansatz for the Ruijsenaars Model of BC_1-Type

    NASA Astrophysics Data System (ADS)

    Chalykh, Oleg

    2007-02-01

    We consider one-dimensional elliptic Ruijsenaars model of type BC1. It is given by a three-term difference Schrödinger operator L containing 8 coupling constants. We show that when all coupling constants are integers, L has meromorphic eigenfunctions expressed by a variant of Bethe ansatz. This result generalizes the Bethe ansatz formulas known in the A1-case.

  14. Sosigenes of Alexandria (c. 50 or 90 BC-?)

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    Peripatetic Greek philosopher, born in Alexandria, astronomer and mathematician who advised Julius Caesar on calendar reform. He recommended a year of 365.25 days, and inserted extra days into the year 46 BC to bring the calendar back in register with the seasons. His account of Eudoxus's planetary system is the most complete surviving account....

  15. Bacterial Cellulose (BC) as a Functional Nanocomposite Biomaterial

    NASA Astrophysics Data System (ADS)

    Nandgaonkar, Avinav Ghanashyam

    Cellulosic is the most abundant biopolymer in the landscape and can be found in many different organisms. It has been already seen use in the medical field, for example cotton for wound dressings and sutures. Although cellulose is naturally occurring and has found a number of applications inside and outside of the medical field, it is not typically produced in its pure state. A lengthy process is required to separate the lignin, hemicelluloses and other molecules from the cellulose in most renewables (wood, agricultural fibers such as cotton, monocots, grasses, etc.). Although bacterial cellulose has a similar chemical structure to plant cellulose, it is easier to process because of the absence of lignin and hemicelluloses which require a lot of energy and chemicals for removal. Bacterial cellulose (BC) is produced from various species of bacteria such as Gluconacetobacter xylinus. Due to its high water uptake, it has the tendency to form gels. It displays high tensile strength, biocompatibility, and purity compared to wood cellulose. It has found applications in fields such as paper, paper products, audio components (e.g., speaker diaphragms), flexible electronics, supercapacitors, electronics, and soft tissue engineering. In my dissertation, we have functionalized and studied BC-based materials for three specific applications: cartilage tissue engineering, bioelectronics, and dye degradation. In our first study, we prepared a highly organized porous material based on BC by unidirectional freezing followed by a freeze-drying process. Chitosan was added to impart additional properties to the resulting BC-based scaffolds that were evaluated in terms of their morphological, chemical, and physical properties for cartilage tissue engineering. The properties of the resulting scaffold were tailored by adjusting the concentration of chitosan over 1, 1.5, and 2 % (by wt-%). The scaffolds containing chitosan showed excellent shape recovery and structural stability after

  16. Drought frequency in central California since 101 B.C. recordered in giant sequoia tree rings

    SciTech Connect

    Hughes, M.K.; Brown, P.M.

    1992-01-01

    Well replicated tree-ring width index chronologies have been developed for giant sequoia at three sites in the Sierra Nevada, California. Extreme low-growth events in these chronologies correspond with regional drought events in the twentieth century in the San Joaquin drainage, in which the giant sequoia sites are located. This relationship is based upon comparison of tree-ring indices with August Palmer Drought Severity Indices for California Climate Division 5. Ring-width indices in the lowest decile from each site were compared. The frequency of low-growth events which occurred at all three sites in the same year is reconstructed from 101 B.C. to A.D. 1988. The inferred frequency of severe drought events changes through time, sometimes suddenly. The period from roughly 1850 to 1950 had one of the lowest frequencies of drought of any one hundred year period in the 2089 year record. The twentieth century so far has had a below-average frequency of extreme droughts. 26 refs., 6 figs., 1 tab.

  17. Drought frequency in central California since 101 B.C. recorded in giant sequoia tree rings

    NASA Astrophysics Data System (ADS)

    Hughes, Malcolm K.; Brown, Peter M.

    1992-01-01

    Well replicated tree-ring width index chronologies have been developed for giant sequoia at three sites in the Sierra Nevada, California. Extreme low-growth events in these chronologies correspond with regional drought events in the twentieth century in the San Joaquin drainage, in which the giant sequoia sites are located. This relationship is based upon comparison of tree-ring indices with August Palmer Drought Severity Indices for California Climate Division 5. Ring-width indices in the lowest decile from each site were compared. The frequency of low-growth events which occurred at all three sites in the same year is reconstructed from 101 B.C. to A.D. 1988. The inferred frequency of severe drought events changes through time, sometimes suddenly. The period from roughly 1850 to 1950 had one of the lowest frequencies of drought of any one hundred year period in the 2089 year record. The twentieth century so far has had a below-average frequency of extreme droughts.

  18. Favored Bc decay modes to search for a Majorana neutrino

    NASA Astrophysics Data System (ADS)

    Mandal, Sanjoy; Sinha, Nita

    2016-08-01

    Recently, the LHCb collaboration reported the observation of the decay mode Bc-→B¯s 0π- with the largest exclusive branching fraction amongst the known decay modes of all the B mesons. Here we propose a search for a few lepton-number violating (Δ L =2 ) decay modes of Bc which can only be induced by Majorana neutrinos. Distinguishing between Dirac and Majorana nature of neutrinos is an outstanding problem and hence, all possible searches for Majorana neutrinos need to be carried out. Since the lepton number violating modes are expected to be rare, when using meson decay modes for these searches one expects CKM favored modes to be the preferred ones; Bc→Bs is one such transition. With a resonance enhancement of the Majorana neutrino mediating the Bc-→B¯s 0ℓ1-ℓ2-π+ modes one can hope to observe these rare modes, or, even their nonobservation can be used to obtain tight constraints on the mixing angles of the heavy Majorana singlet with the light flavour neutrinos from upper limits of the branching fractions. Using these modes we obtain exclusion curves for the mixing angles which are tighter or compatible with results from earlier studies. However, we find that the relatively suppressed mode Bc-→J /ψ ℓ1- ℓ2-π+ can provide even tighter constraints on |Ve N|2, |Vμ N|2, |Ve NVμ N|, and in a larger range of the heavy neutrino mass. Further, exclusion regions for |Ve NVτ N|, |Vμ NVτ N| can also be obtained for masses larger than those accessible in tau decays. Upper limits on B (Bc-→π+ℓ1- ℓ2-) can also result in stringent exclusion curves for all the mixing elements, including that for |Vτ N|2 in a mass range where it is unconstrained thus far.

  19. Overview of Hydrometeorologic Forecasting Procedures at BC Hydro

    NASA Astrophysics Data System (ADS)

    McCollor, D.

    2004-12-01

    Energy utility companies must balance production from limited sources with increasing demand from industrial, business, and residential consumers. The utility planning process requires a balanced, efficient, and effective distribution of energy from source to consumer. Therefore utility planners must consider the impact of weather on energy production and consumption. Hydro-electric companies should be particularly tuned to weather because their source of energy is water, and water supply depends on precipitation. BC Hydro operates as the largest hydro-electric company in western Canada, managing over 30 reservoirs within the province of British Columbia, and generating electricity for 1.6 million people. BC Hydro relies on weather forecasts of watershed precipitation and temperature to drive hydrologic reservoir inflow models and of urban temperatures to meet energy demand requirements. Operations and planning specialists in the company rely on current, value-added weather forecasts for extreme high-inflow events, daily reservoir operations planning, and long-term water resource management. Weather plays a dominant role for BC Hydro financial planners in terms of sensitive economic responses. For example, a two percent change in hydropower generation, due in large part to annual precipitation patterns, results in an annual net change of \\50 million in earnings. A five percent change in temperature produces a \\5 million change in yearly earnings. On a daily basis, significant precipitation events or temperature extremes involve potential profit/loss decisions in the tens of thousands of dollars worth of power generation. These factors are in addition to environmental and societal costs that must be considered equally as part of a triple bottom line reporting structure. BC Hydro water resource managers require improved meteorological information from recent advancements in numerical weather prediction. At BC Hydro, methods of providing meteorological forecast data

  20. Conservation of lipid functions in cytochrome bc complexes.

    PubMed

    Hasan, S Saif; Yamashita, Eiki; Ryan, Christopher M; Whitelegge, Julian P; Cramer, William A

    2011-11-18

    Lipid binding sites and properties are compared in two sub-families of hetero-oligomeric membrane protein complexes known to have similar functions in order to gain further understanding of the role of lipid in the function, dynamics, and assembly of these complexes. Using the crystal structure information for both complexes, we compared the lipid binding properties of the cytochrome b(6)f and bc(1) complexes that function in photosynthetic and respiratory membrane energy transduction. Comparison of lipid and detergent binding sites in the b(6)f complex with those in bc(1) shows significant conservation of lipid positions. Seven lipid binding sites in the cyanobacterial b(6)f complex overlap three natural sites in the Chlamydomonas reinhardtii algal complex and four sites in the yeast mitochondrial bc(1) complex. The specific identity of lipids is different in b(6)f and bc(1) complexes: b(6)f contains sulfoquinovosyldiacylglycerol, phosphatidylglycerol, phosphatidylcholine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol, whereas cardiolipin, phosphatidylethanolamine, and phosphatidic acid are present in the yeast bc(1) complex. The lipidic chlorophyll a and β-carotene (β-car) in cyanobacterial b(6)f, as well as eicosane in C. reinhardtii, are unique to the b(6)f complex. Inferences of lipid binding sites and functions were supported by sequence, interatomic distance, and B-factor information on interacting lipid groups and coordinating amino acid residues. The lipid functions inferred in the b(6)f complex are as follows: (i) substitution of a transmembrane helix by a lipid and chlorin ring, (ii) lipid and β-car connection of peripheral and core domains, (iii) stabilization of the iron-sulfur protein transmembrane helix, (iv) n-side charge and polarity compensation, and (v) β-car-mediated super-complex with the photosystem I complex. PMID:21978667

  1. Reading & Accountability: Improving 21st Century Schools. Hearing before the Committee on Education and the Workforce. House of Representatives, One Hundred Seventh Congress, First Session (Marietta, Georgia, February 20, 2001).

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Committee on Education and the Workforce.

    A hearing, held in Marietta, Georgia, on February 20, 2001, before the Committee on Education and the Workforce, House of Representatives, 107th Congress, dealt with reading and accountability and improving 21st century schools. These proceedings of the hearing contain the following: Statement of Congressman Bob Barr, 7th District of Georgia, U.S.…

  2. Geomagnetic field variations in Western Europe from 1500 BC to 200 AD. Part II: New intensity secular variation curve

    NASA Astrophysics Data System (ADS)

    Hervé, Gwenaël; Chauvin, Annick; Lanos, Philippe

    2013-05-01

    a new Western Europe VGPs and VDMs mean curves. Comparison with the predictions given by the global models points out a possible persistent non-dipole fields effect over Europe between 1000 BC and 600-500 BC. Finally, we note that the strong variations of intensity of the geomagnetic field (with a mean decrease rate per century close to 6 μT) will be useful for archaeomagnetic dating purposes.

  3. Involvement of protein tyrosine phosphatases BcPtpA and BcPtpB in regulation of vegetative development, virulence and multi-stress tolerance in Botrytis cinerea.

    PubMed

    Yang, Qianqian; Yu, Fangwei; Yin, Yanni; Ma, Zhonghua

    2013-01-01

    Tyrosine phosphorylation and dephosphorylation have emerged as fundamentally important mechanisms of signal transduction and regulation in eukaryotic cells, governing many processes, but little has been known about their functions in filamentous fungi. In this study, we deleted two putative protein tyrosine phosphatase (PTP) genes (BcPTPA and BcPTPB) in Botrytis cinerea, encoding the orthologs of Saccharomyces cerevisiae Ptp2 and Ptp3, respectively. Although BcPtpA and BcPtpB have opposite functions in conidiation, they are essential for sclerotial formation in B. cinerea. BcPTPA and BcPTPB deletion mutants ΔBcPtpA-10 and ΔBcPtpB-4 showed significantly increased sensitivity to osmotic and oxidative stresses, and to cell wall damaging agents. Inoculation tests showed that both mutants exhibited dramatically decreased virulence on tomato leaves, apples and grapes. In S. cerevisiae, it has been shown that Ptp2 and Ptp3 negatively regulate the high-osmolarity glycerol (HOG) pathway and the cell wall integrity (CWI) pathway. Although both BcPtpA and BcPtpB were able to inactive Hog1 and Mpk1 in S. cerevisiae, in contrast to S. cerevisiae, they positively regulate phosphorylation of BcSak1 (the homologue of Hog1) and BcBmp3 (the homologue of Mpk1) in B. cinerea under stress conditions. These results demonstrated that functions of PTPs in B. cinerea are different from those in S. cerevisiae, and BcPtpA and BcPtpB play important roles in regulation of vegetative development, virulence and in adaptation to oxidative, osmotic and cell-wall damage stresses in B. cinerea. PMID:23585890

  4. Variation of the intensity of the Earth's magnetic field in Portugal in the 1st millennium BC

    NASA Astrophysics Data System (ADS)

    Nachasova, I. E.; Burakov, K. S.

    2009-07-01

    The study of magnetization of the ceramic material from 21 archeological monuments of Portugal (the Evora province), dated archeologically from the Bronze Age to the end of the Iron Age has been carried out. For the purpose of more detailed timing of the material from the monuments the method of ceramic age dating on the basis of its porosity has been used. In order to take into account the distorted factors in the determination of the parameters of the ancient geomagnetic field with the aim of the maximal approximation to the actual values the diagnostic features of magnetite weathering have been considered and the level of weathering of the magnetic fraction in the ceramics from archeological monuments has been determined. The data of geomagnetic field-strength variation in the time interval of the 12th century BC to the beginning of the Common Era have been obtained. The field-strength at this time interval varied in the range of 60-90 micro Tesla with the maximal values in the 9th, 8th, and the second half of the 5th to the beginning of the 4th century BC. In addition, the timing of the ceramic material from the urns of the megalithic complex Monte de Tera of the Evora province has been clarified.

  5. The effects of hygroscopicity of fossil fuel BC on mixed-phase and cirrus ice clouds

    NASA Astrophysics Data System (ADS)

    Yun, Y.; Penner, J. E.

    2010-12-01

    Fossil fuel burning BC aerosols are often emitted together with sulfate, which coats the surface of these BC particles and changes their hygroscopicity. The ice forming capability of the fossil fuel burning BC can differ widely as a result of the amount of soluble coating on their surface. Due to the abundance of fossil fuel burning BC particles, a small change in their activated fraction can produce a large difference in their climate forcing. To better quantify the role of fossil fuel burning BC in climate change, a 3-BC (hydrophobic, hydrophilic and hygroscopic BC) scheme is developed to replace the 1-BC scheme in a coupled climate and aerosol transport model (CAM-IMPACT). The new scheme explicitly calculates the condensation and coagulation of sulfate on BC particles and keeps track of their coating in the 3-BC states. The hygroscopicity of BC is determined by the layers of sulfate coating on their surface according to criteria developed in laboratory observations. The ice formation scheme in mixed-phase and cirrus clouds is also updated to treat the 3 hygroscopicity BC groups separately according to their different ice freezing capabilities. This paper will report the climate forcing associated with the new BC scheme as well as comparison with observations.

  6. Lansoprazole is an antituberculous prodrug targeting cytochrome bc1

    PubMed Central

    Rybniker, Jan; Vocat, Anthony; Sala, Claudia; Busso, Philippe; Pojer, Florence; Benjak, Andrej; Cole, Stewart T.

    2015-01-01

    Better antibiotics capable of killing multi-drug-resistant Mycobacterium tuberculosis are urgently needed. Despite extensive drug discovery efforts, only a few promising candidates are on the horizon and alternative screening protocols are required. Here, by testing a panel of FDA-approved drugs in a host cell-based assay, we show that the blockbuster drug lansoprazole (Prevacid), a gastric proton-pump inhibitor, has intracellular activity against M. tuberculosis. Ex vivo pharmacokinetics and target identification studies reveal that lansoprazole kills M. tuberculosis by targeting its cytochrome bc1 complex through intracellular sulfoxide reduction to lansoprazole sulfide. This novel class of cytochrome bc1 inhibitors is highly active against drug-resistant clinical isolates and spares the human H+K+-ATPase thus providing excellent opportunities for targeting the major pathogen M. tuberculosis. Our finding provides proof of concept for hit expansion by metabolic activation, a powerful tool for antibiotic screens. PMID:26158909

  7. Exploring distributed leadership in the BC Sepsis Network.

    PubMed

    Gorley, Charlotte; Lindstrom, Ronald R; McKeown, Shari; Krause, Christina; Pamplin, Chantale; Sweet, David; Marsden, Julian; Kennedy, Colleen

    2016-03-01

    Commissioned research was undertaken to explore the role of networks in supporting large-scale change and improvement. Participatory action research and social network analysis were used to study the BC Sepsis Network. Findings of this research include insights into distributed leadership, enablers and barriers within a network approach; the importance of relationships and trust; and the need for meaningful and timely data. Recommendations are made for health leaders who are considering utilizing networks for improving patient quality and safety. PMID:26872797

  8. Maintenance procedures catalogue: BC Hydro International Ltd. , October 1992

    SciTech Connect

    Not Available

    1992-01-01

    New catalogue lists over 1,000 written procedures developed over the past 25 years by BC Hydro personnel, both in the field and in the company's research and development division that are available for purchase from the Canadian utility. Developed at a cost of an estimated $5 million, the procedure documents cover Apparatus, Protection and Control, Safety, Distribution Standards, Engineering Contracts and Live Line Training. Procedures listed in the catalogue are available in both hard copy and electronic formats.

  9. Evaluating Earth and Space Sciences STEM Research Communication in 7th-12th Grade Rural Mississippi Classrooms and Resulting Student Attitudinal Impacts

    NASA Astrophysics Data System (ADS)

    Radencic, S.; McNeal, K. S.

    2013-05-01

    Observation and evaluation of STEM graduate students from Mississippi State University communicating their research of the Earth and Space Sciences in rural 7th-12th grade classrooms participating in the Initiating New Science Partnerships in Rural Education (INSPIRE) NSF GK-12 project. The methods they utilize to communicate their STEM research includes introducing new technologies and inquiry based learning experiences. These communication experiences have been observed and evaluated using two observational systems, the Mathematics Science Classroom Observational Profile System (M-SCOPS) and the Presentation Skills Protocol (PSP). M-SCOPS has been used over the first three years of the project to evaluate what Earth and Space research the STEM graduate students communicate in classroom activities along with how they are introducing STEM research through a variety of communication methods and levels of understanding. PSP, which INSPIRE began using this year, evaluates and provides feedback to the STEM graduate students on their communication during these classroom experiences using a rubric covering a range of skills for successful communication. PSP also allows the participating INSPIRE teacher partners to provide feedback to the STEM graduate students about development of their communication skills over the course of the year. In addition to feedback from the INSPIRE project and participating teachers, the STEM graduate students have the opportunity to evaluate their personal communication skills through video documentation to determine specific skills they would like to improve. Another area of research to be discussed is how the STEM graduate students communicating Earth and Space sciences research in the participating classrooms is impacting student attitudes about science and mathematics over the last three years. Student Attitudinal Surveys (SAS) are administered as a pre-evaluation tool in the fall when the STEM graduate students first enter into their

  10. Profile of BC College Transfer Students 2003/04 to 2007/08. Research Results

    ERIC Educational Resources Information Center

    Lambert-Maberly, Ashley

    2010-01-01

    This newsletter summarizes the results from five reports commissioned by the British Columbia Council on Admissions and Transfer (BCCAT) that profiled the academic experiences and demographics of BC college transfer students: those students who transferred from a BC college, university college, or institute to a BC university during the period…

  11. Evolutionary concepts in biobanking - the BC BioLibrary

    PubMed Central

    2009-01-01

    Background Medical research to improve health care faces a major problem in the relatively limited availability of adequately annotated and collected biospecimens. This limitation is creating a growing gap between the pace of scientific advances and successful exploitation of this knowledge. Biobanks are an important conduit for transfer of biospecimens (tissues, blood, body fluids) and related health data to research. They have evolved outside of the historical source of tissue biospecimens, clinical pathology archives. Research biobanks have developed advanced standards, protocols, databases, and mechanisms to interface with researchers seeking biospecimens. However, biobanks are often limited in their capacity and ability to ensure quality in the face of increasing demand. Our strategy to enhance both capacity and quality in research biobanking is to create a new framework that repatriates the activity of biospecimen accrual for biobanks to clinical pathology. Methods The British Columbia (BC) BioLibrary is a framework to maximize the accrual of high-quality, annotated biospecimens into biobanks. The BC BioLibrary design primarily encompasses: 1) specialized biospecimen collection units embedded within clinical pathology and linked to a biospecimen distribution system that serves biobanks; 2) a systematic process to connect potential donors with biobanks, and to connect biobanks with consented biospecimens; and 3) interdisciplinary governance and oversight informed by public opinion. Results The BC BioLibrary has been embraced by biobanking leaders and translational researchers throughout BC, across multiple health authorities, institutions, and disciplines. An initial pilot network of three Biospecimen Collection Units has been successfully established. In addition, two public deliberation events have been held to obtain input from the public on the BioLibrary and on issues including consent, collection of biospecimens and governance. Conclusion The BC Bio

  12. The physiognomist's kidney in the fifteenth century.

    PubMed

    Ziegler, Joseph

    2004-01-01

    Physiognomy, the art of deciphering a person's character and potential behavior by his or her external appearance, is an ancient body of knowledge which was gradually revived in the Latin West in the twelfth and particularly in the thirteenth century. This is a philological study of the scientific discourse about the physiognomy of the kidney in physiognomic sources from Pseudo-Aristotle's Physiognomonics (third century B.C.) through Pietro d'Abano's Liber compilationis phisonomie (ca 1295) to Rolandus Scriptoris's Reductorium phisonomie (ca 1430). Fifteenth-century learned physiognomists devoted specific chapters to the kidney. The physiognomists analyzed the fleshiness of the body-surface outside the kidneys (i.e. the loins and their vicinity). Firm loins denoted boldness, agility, and good fighting capacity and vice versa. The pre-modern kidney was of interest not only to physicians and surgeons wishing to treat kidney conditions and other pathologies arising from the urinary system. There were learned physicians who examined the body not to diagnose diseases, but to decipher their patient's personality. When engaged in this activity the kidneys, that is, the loins or the external area of the kidneys, were one of the body parts that could provide vital physiognomic information. PMID:15372426

  13. Ninety-day oral toxicity studies on two genetically modified maize MON810 varieties in Wistar Han RCC rats (EU 7th Framework Programme project GRACE).

    PubMed

    Zeljenková, Dagmar; Ambrušová, Katarína; Bartušová, Mária; Kebis, Anton; Kovrižnych, Jevgenij; Krivošíková, Zora; Kuricová, Miroslava; Líšková, Aurélia; Rollerová, Eva; Spustová, Viera; Szabová, Elena; Tulinská, Jana; Wimmerová, Soňa; Levkut, Mikuláš; Révajová, Viera; Ševčíková, Zuzana; Schmidt, Kerstin; Schmidtke, Jörg; La Paz, Jose Luis; Corujo, Maria; Pla, Maria; Kleter, Gijs A; Kok, Esther J; Sharbati, Jutta; Hanisch, Carlos; Einspanier, Ralf; Adel-Patient, Karine; Wal, Jean-Michel; Spök, Armin; Pöting, Annette; Kohl, Christian; Wilhelm, Ralf; Schiemann, Joachim; Steinberg, Pablo

    2014-12-01

    The GMO Risk Assessment and Communication of Evidence (GRACE; www.grace-fp7.eu ) project is funded by the European Commission within the 7th Framework Programme. A key objective of GRACE is to conduct 90-day animal feeding trials, animal studies with an extended time frame as well as analytical, in vitro and in silico studies on genetically modified (GM) maize in order to comparatively evaluate their use in GM plant risk assessment. In the present study, the results of two 90-day feeding trials with two different GM maize MON810 varieties, their near-isogenic non-GM varieties and four additional conventional maize varieties are presented. The feeding trials were performed by taking into account the guidance for such studies published by the EFSA Scientific Committee in 2011 and the OECD Test Guideline 408. The results obtained show that the MON810 maize at a level of up to 33 % in the diet did not induce adverse effects in male and female Wistar Han RCC rats after subchronic exposure, independently of the two different genetic backgrounds of the event. PMID:25270621

  14. Unique Characteristics of the Pyrrolysine System in the 7th Order of Methanogens: Implications for the Evolution of a Genetic Code Expansion Cassette

    PubMed Central

    Borrel, Guillaume; Gaci, Nadia; Peyret, Pierre; O'Toole, Paul W.; Gribaldo, Simonetta

    2014-01-01

    Pyrrolysine (Pyl), the 22nd proteogenic amino acid, was restricted until recently to few organisms. Its translational use necessitates the presence of enzymes for synthesizing it from lysine, a dedicated amber stop codon suppressor tRNA, and a specific amino-acyl tRNA synthetase. The three genomes of the recently proposed Thermoplasmata-related 7th order of methanogens contain the complete genetic set for Pyl synthesis and its translational use. Here, we have analyzed the genomic features of the Pyl-coding system in these three genomes with those previously known from Bacteria and Archaea and analyzed the phylogeny of each component. This shows unique peculiarities, notably an amber tRNAPyl with an imperfect anticodon stem and a shortened tRNAPyl synthetase. Phylogenetic analysis indicates that a Pyl-coding system was present in the ancestor of the seventh order of methanogens and appears more closely related to Bacteria than to Methanosarcinaceae, suggesting the involvement of lateral gene transfer in the spreading of pyrrolysine between the two prokaryotic domains. We propose that the Pyl-coding system likely emerged once in Archaea, in a hydrogenotrophic and methanol-H2-dependent methylotrophic methanogen. The close relationship between methanogenesis and the Pyl system provides a possible example of expansion of a still evolving genetic code, shaped by metabolic requirements. PMID:24669202

  15. Measurements of B(c)+ production and mass with the B(c)+ → J/ψπ+ decay.

    PubMed

    Aaij, R; Abellan Beteta, C; Adametz, A; Adeva, B; Adinolfi, M; Adrover, C; Affolder, A; Ajaltouni, Z; Albrecht, J; Alessio, F; Alexander, M; Ali, S; Alkhazov, G; Alvarez Cartelle, P; Alves, A A; Amato, S; Amhis, Y; Anderlini, L; Anderson, J; Appleby, R B; Aquines Gutierrez, O; Archilli, F; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Bachmann, S; Back, J J; Baesso, C; Baldini, W; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Bates, A; Bauer, Th; Bay, A; Beddow, J; Bediaga, I; Belogurov, S; Belous, K; Belyaev, I; Ben-Haim, E; Benayoun, M; Bencivenni, G; Benson, S; Benton, J; Berezhnoy, A; Bernet, R; Bettler, M-O; van Beuzekom, M; Bien, A; Bifani, S; Bird, T; Bizzeti, A; Bjørnstad, P M; Blake, T; Blanc, F; Blanks, C; Blouw, J; Blusk, S; Bobrov, A; Bocci, V; Bondar, A; Bondar, N; Bonivento, W; Borghi, S; Borgia, A; Bowcock, T J V; Bozzi, C; Brambach, T; van den Brand, J; Bressieux, J; Brett, D; Britsch, M; Britton, T; Brook, N H; Brown, H; Büchler-Germann, A; Burducea, I; Bursche, A; Buytaert, J; Cadeddu, S; Callot, O; Calvi, M; Calvo Gomez, M; Camboni, A; Campana, P; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carson, L; Carvalho Akiba, K; Casse, G; Cattaneo, M; Cauet, Ch; Charles, M; Charpentier, Ph; Chen, P; Chiapolini, N; Chrzaszcz, M; Ciba, K; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Coca, C; Coco, V; Cogan, J; Cogneras, E; Collins, P; Comerma-Montells, A; Contu, A; Cook, A; Coombes, M; Corti, G; Couturier, B; Cowan, G A; Craik, D; Cunliffe, S; Currie, R; D'Ambrosio, C; David, P; David, P N Y; De Bonis, I; De Bruyn, K; De Capua, S; De Cian, M; De Miranda, J M; De Paula, L; De Simone, P; Decamp, D; Deckenhoff, M; Degaudenzi, H; Del Buono, L; Deplano, C; Derkach, D; Deschamps, O; Dettori, F; Di Canto, A; Dickens, J; Dijkstra, H; Diniz Batista, P; Domingo Bonal, F; Donleavy, S; Dordei, F; Dosil Suárez, A; Dossett, D; Dovbnya, A; Dupertuis, F; Dzhelyadin, R; Dziurda, A; Dzyuba, A; Easo, S; Egede, U; Egorychev, V; Eidelman, S; van Eijk, D; Eisenhardt, S; Ekelhof, R; Eklund, L; El Rifai, I; Elsasser, Ch; Elsby, D; Esperante Pereira, D; Falabella, A; Färber, C; Fardell, G; Farinelli, C; Farry, S; Fave, V; Fernandez Albor, V; Ferreira Rodrigues, F; Ferro-Luzzi, M; Filippov, S; Fitzpatrick, C; Fontana, M; Fontanelli, F; Forty, R; Francisco, O; Frank, M; Frei, C; Frosini, M; Furcas, S; Gallas Torreira, A; Galli, D; Gandelman, M; Gandini, P; Gao, Y; Garnier, J-C; Garofoli, J; Garosi, P; Garra Tico, J; Garrido, L; Gaspar, C; Gauld, R; Gersabeck, E; Gersabeck, M; Gershon, T; Ghez, Ph; Gibson, V; Gligorov, V V; Göbel, C; Golubkov, D; Golutvin, A; Gomes, A; Gordon, H; Grabalosa Gándara, M; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graziani, G; Grecu, A; Greening, E; Gregson, S; Grünberg, O; Gui, B; Gushchin, E; Guz, Yu; Gys, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hall, S; Hampson, T; Hansmann-Menzemer, S; Harnew, N; Harnew, S T; Harrison, J; Harrison, P F; Hartmann, T; He, J; Heijne, V; Hennessy, K; Henrard, P; Hernando Morata, J A; van Herwijnen, E; Hicks, E; Hill, D; Hoballah, M; Hopchev, P; Hulsbergen, W; Hunt, P; Huse, T; Hussain, N; Hutchcroft, D; Hynds, D; Iakovenko, V; Ilten, P; Imong, J; Jacobsson, R; Jaeger, A; Jahjah Hussein, M; Jans, E; Jansen, F; Jaton, P; Jean-Marie, B; Jing, F; John, M; Johnson, D; Jones, C R; Jost, B; Kaballo, M; Kandybei, S; Karacson, M; Karbach, T M; Keaveney, J; Kenyon, I R; Kerzel, U; Ketel, T; Keune, A; Khanji, B; Kim, Y M; Kochebina, O; Komarov, V; Koopman, R F; Koppenburg, P; Korolev, M; Kozlinskiy, A; Kravchuk, L; Kreplin, K; Kreps, M; Krocker, G; Krokovny, P; Kruse, F; Kucharczyk, M; Kudryavtsev, V; Kvaratskheliya, T; La Thi, V N; Lacarrere, D; Lafferty, G; Lai, A; Lambert, D; Lambert, R W; Lanciotti, E; Lanfranchi, G; Langenbruch, C; Latham, T; Lazzeroni, C; Le Gac, R; van Leerdam, J; Lees, J-P; Lefèvre, R; Leflat, A; Lefrançois, J; Leroy, O; Lesiak, T; Li, Y; Li Gioi, L; Liles, M; Lindner, R; Linn, C; Liu, B; Liu, G; von Loeben, J; Lopes, J H; Lopez Asamar, E; Lopez-March, N; Lu, H; Luisier, J; Mac Raighne, A; Machefert, F; Machikhiliyan, I V; Maciuc, F; Maev, O; Magnin, J; Maino, M; Malde, S; Manca, G; Mancinelli, G; Mangiafave, N; Marconi, U; Märki, R; Marks, J; Martellotti, G; Martens, A; Martin, L; Martín Sánchez, A; Martinelli, M; Martinez Santos, D; Massafferri, A; Mathe, Z; Matteuzzi, C; Matveev, M; Maurice, E; Mazurov, A; McCarthy, J; McGregor, G; McNulty, R; Meissner, M; Merk, M; Merkel, J; Milanes, D A; Minard, M-N; Molina Rodriguez, J; Monteil, S; Moran, D; Morawski, P; Mountain, R; Mous, I; Muheim, F; Müller, K; Muresan, R; Muryn, B; Muster, B; Mylroie-Smith, J; Naik, P; Nakada, T; Nandakumar, R; Nasteva, I; Needham, M; Neufeld, N; Nguyen, A D; Nguyen-Mau, C; Nicol, M; Niess, V; Nikitin, N; Nikodem, T; Nomerotski, A; Novoselov, A; Oblakowska-Mucha, A; Obraztsov, V; Oggero, S; Ogilvy, S; Okhrimenko, O; Oldeman, R; Orlandea, M; Otalora Goicochea, J M; Owen, P; Pal, B K; Palano, A; Palutan, M; Panman, J; Papanestis, A; Pappagallo, M; Parkes, C; Parkinson, C J; Passaleva, G; Patel, G D; Patel, M; Patrick, G N; Patrignani, C; Pavel-Nicorescu, C; Pazos Alvarez, A; Pellegrino, A; Penso, G; Pepe Altarelli, M; Perazzini, S; Perego, D L; Perez Trigo, E; Pérez-Calero Yzquierdo, A; Perret, P; Perrin-Terrin, M; Pessina, G; Petridis, K; Petrolini, A; Phan, A; Picatoste Olloqui, E; Pie Valls, B; Pietrzyk, B; Pilař, T; Pinci, D; Playfer, S; Plo Casasus, M; Polci, F; Polok, G; Poluektov, A; Polycarpo, E; Popov, D; Popovici, B; Potterat, C; Powell, A; Prisciandaro, J; Pugatch, V; Puig Navarro, A; Qian, W; Rademacker, J H; Rakotomiaramanana, B; Rangel, M S; Raniuk, I; Rauschmayr, N; Raven, G; Redford, S; Reid, M M; dos Reis, A C; Ricciardi, S; Richards, A; Rinnert, K; Rives Molina, V; Roa Romero, D A; Robbe, P; Rodrigues, E; Rodriguez Perez, P; Rogers, G J; Roiser, S; Romanovsky, V; Romero Vidal, A; Rouvinet, J; Ruf, T; Ruiz, H; Sabatino, G; Saborido Silva, J J; Sagidova, N; Sail, P; Saitta, B; Salzmann, C; Sanmartin Sedes, B; Sannino, M; Santacesaria, R; Santamarina Rios, C; Santinelli, R; Santovetti, E; Sapunov, M; Sarti, A; Satriano, C; Satta, A; Savrie, M; Schaack, P; Schiller, M; Schindler, H; Schleich, S; Schlupp, M; Schmelling, M; Schmidt, B; Schneider, O; Schopper, A; Schune, M-H; Schwemmer, R; Sciascia, B; Sciubba, A; Seco, M; Semennikov, A; Senderowska, K; Sepp, I; Serra, N; Serrano, J; Seyfert, P; Shapkin, M; Shapoval, I; Shatalov, P; Shcheglov, Y; Shears, T; Shekhtman, L; Shevchenko, O; Shevchenko, V; Shires, A; Silva Coutinho, R; Skwarnicki, T; Smith, N A; Smith, E; Smith, M; Sobczak, K; Soler, F J P; Soomro, F; Souza, D; Souza De Paula, B; Spaan, B; Sparkes, A; Spradlin, P; Stagni, F; Stahl, S; Steinkamp, O; Stoica, S; Stone, S; Storaci, B; Straticiuc, M; Straumann, U; Subbiah, V K; Swientek, S; Szczekowski, M; Szczypka, P; Szumlak, T; T'Jampens, S; Teklishyn, M; Teodorescu, E; Teubert, F; Thomas, C; Thomas, E; van Tilburg, J; Tisserand, V; Tobin, M; Tolk, S; Tonelli, D; Topp-Joergensen, S; Torr, N; Tournefier, E; Tourneur, S; Tran, M T; Tsaregorodtsev, A; Tsopelas, P; Tuning, N; Ubeda Garcia, M; Ukleja, A; Urner, D; Uwer, U; Vagnoni, V; Valenti, G; Vazquez Gomez, R; Vazquez Regueiro, P; Vecchi, S; Velthuis, J J; Veltri, M; Veneziano, G; Vesterinen, M; Viaud, B; Videau, I; Vieira, D; Vilasis-Cardona, X; Visniakov, J; Vollhardt, A; Volyanskyy, D; Voong, D; Vorobyev, A; Vorobyev, V; Voss, H; Voss, C; Waldi, R; Wallace, R; Wandernoth, S; Wang, J; Ward, D R; Watson, N K; Webber, A D; Websdale, D; Whitehead, M; Wicht, J; Wiedner, D; Wiggers, L; Wilkinson, G; Williams, M P; Williams, M; Wilson, F F; Wishahi, J; Witek, M; Witzeling, W; Wotton, S A; Wright, S; Wu, S; Wyllie, K; Xie, Y; Xing, F; Xing, Z; Yang, Z; Young, R; Yuan, X; Yushchenko, O; Zangoli, M; Zavertyaev, M; Zhang, F; Zhang, L; Zhang, W C; Zhang, Y; Zhelezov, A; Zhong, L; Zvyagin, A

    2012-12-01

    Measurements of B(c)(+) production and mass are performed with the decay mode B(c)(+)→J/ψπ(+) using 0.37 fb(-1) of data collected in pp collisions at √[s]=7 TeV by the LHCb experiment. The ratio of the production cross section times branching fraction between the B(c)(+)→J/ψπ(+) and the B(+)→J/ψK(+) decays is measured to be (0.68±0.10(stat)±0.03(syst)±0.05(lifetime))% for B(c)(+) and B(+) mesons with transverse momenta p(T)>4 GeV/c and pseudorapidities 2.5<η<4.5. The B(c)(+) mass is directly measured to be 6273.7±1.3(stat)±1.6(syst) MeV/c(2), and the measured mass difference with respect to the B(+) meson is M(B(c)(+))-M(B(+))=994.6±1.3(stat)±0.6(syst) MeV/c(2). PMID:23368183

  16. Geomagnetic field intensity in the eastern Mediterranean region in the second half of the 1st millennium BC and the beginning of our era

    NASA Astrophysics Data System (ADS)

    Nachasova, I. E.; Burakov, K. S.; Il'Ina, T. A.

    2007-12-01

    The magnetization of ceramic material manufactured in the eastern Mediterranean is studied. Data on the variation in geomagnetic field intensity in the time interval from the fourth-quarter of the 6th century BC through the 2nd century AD are obtained. The main tendency of the variation in the field intensity until approximately the middle of this interval is its decrease, after which the average intensity level varied insignificantly over the three next centuries. Variations with characteristic times of a few tens to a few hundreds of years are superimposed on the smooth variation in the field intensity approximated by a sinusoid with a period of 1600 yr. The data obtained in this work confirm the previously derived conclusion that short-term intensity variations have been permanently present in the geomagnetic field in the recent millennia.

  17. Industrial Arts: "Youth's Gateway to the Future." Addresses and Proceedings of the 40th National and 7th International Conference of the American Industrial Arts Association (Atlanta, Georgia, February 27-March 3, 1978).

    ERIC Educational Resources Information Center

    Northern Kentucky Univ., Highland Heights.

    Included in this document are the addresses and proceedings of the 40th National and 7th International Annual Conference of the American Industrial Arts Association. The proceedings are organized by the following subject groups: career education, curriculum, drafting, electricity/electronics, elementary school industrial arts, energy, evaluation,…

  18. Final Report for Grant No. DE-FG02-03ER54706 "Support for the 7th Workshop on The Interrelationship between Plasma Experiment in Laboratory and Space"

    SciTech Connect

    C. Kletzing

    2005-09-13

    We describe the support given to support the 7th IPELS meeting which brings together space and laboratory based physicists. The meeting was a great success with more than 80 attendees and a significant number of young scientists. The major topics of discussion were magnetic reconnection, plasma turbulence, and waves in plasmas.

  19. Biomedical Challenges Presented by the American Indian, Proceedings of the Special Session of the PAHO Advisory Committee on Medical Research (7th, Washington, D.C., June 25, 1968).

    ERIC Educational Resources Information Center

    Pan American Health Organization, Washington, DC.

    At each meeting of the Pan American Health Organization Advisory Committee on Medical Research, a special 1-day session is held on a topic chosen by the committee as being of particular interest. At the 7th meeting, which convened in June of 1968 in Washington, D.C., the session surveyed the origin, present distribution, and principal biological…

  20. Regulation of alternative splicing of Bcl-x by BC200 contributes to breast cancer pathogenesis.

    PubMed

    Singh, R; Gupta, S C; Peng, W-X; Zhou, N; Pochampally, R; Atfi, A; Watabe, K; Lu, Z; Mo, Y-Y

    2016-01-01

    BC200 is a long non-coding RNA (lncRNA) that has been implicated in the regulation of protein synthesis, yet whether dysregulation of BC200 contributes to the pathogenesis of human diseases remains elusive. In this study, we show that BC200 is upregulated in breast cancer; among breast tumor specimens there is a higher level of BC200 in estrogen receptor (ER) positive than in ER-negative tumors. Further experiments show that activation of estrogen signaling induces expression of BC200. To determine the significance of ER-regulated BC200 expression, we knockout (KO) BC200 by CRISPR/Cas9. BC200 KO suppresses tumor cell growth in vitro and in vivo by expression of the pro-apoptotic Bcl-xS isoform. Mechanistically, BC200 contains a 17-nucleotide sequence complementary to Bcl-x pre-mRNA, which may facilitate its binding to Bcl-x pre-mRNA and recruitment of heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1, a known splicing factor. Consequently, hnRNP A2/B1 interferes with association of Bcl-x pre-mRNA with the Bcl-xS-promoting factor Sam68, leading to a blockade of Bcl-xS expression. Together, these results suggest that BC200 plays an oncogenic role in breast cancer. Thus, BC200 may serve as a prognostic marker and possible target for attenuating deregulated cell proliferation in estrogen-dependent breast cancer. PMID:27277684

  1. OPTICAL AND INFRARED ANALYSIS OF TYPE II SN 2006bc

    SciTech Connect

    Gallagher, Joseph S.; Sugerman, B. E. K.; Clayton, Geoffrey C.; Andrews, J. E.; Clem, J. E-mail: ben.sugerman@goucher.edu E-mail: jandrews@phys.lsu.edu; and others

    2012-07-10

    We present nebular phase optical imaging and spectroscopy and near/mid-IR imaging of the Type II SN 2006bc. Observations reveal the central wavelength of the symmetric H{alpha} line profile to be redshifted with respect to the host galaxy H{alpha} emission by day 325. Such a phenomenon has been argued to result from an asymmetric explosion in the iron-peak elements resulting in a larger mass of {sup 56}Ni and higher excitation of hydrogen on the far side of the supernova (SN) explosion. We also observe a gradual blueshifting of this H{alpha} peak which is indicative of dust formation in the ejecta. Although showing a normal peak brightness, V {approx} -17.2, for a core-collapse SN, 2006bc fades by {approx}6 mag during the first 400 days suggesting either a relatively low {sup 56}Ni yield, an increase in extinction due to new dust, or both. A short-duration flattening of the light curve is observed from day 416 to day 541 suggesting an optical light echo. Based on the narrow time window of this echo, we discuss implications on the location and geometry of the reflecting interstellar medium. With our radiative transfer models, we find an upper limit of 2 Multiplication-Sign 10{sup -3} M{sub Sun} of dust around SN 2006bc. In the event that all of this dust were formed during the SN explosion, this quantity of dust is still several orders of magnitude lower than that needed to explain the large quantities of dust observed in the early universe.

  2. Trends of violence among 7th, 8th and 9th grade students in the state of Lara, Venezuela: The Global School Health Survey 2004 and 2008

    PubMed Central

    2011-01-01

    Background Violence by young people is one of the most visible forms of violence and contributes greatly to the global burden of premature death, injury and disability. Methods The Global School-based Student Health Survey (GSHS), State of Lara, Venezuela (GSHS-Lara) is a school-based surveillance system. It comprises a repeated, cross-sectional, self-administered survey drawn from a representative sample of 7th to 9th grade students, performed in the school years 2003-2004 (GSHS-Lara 2004) and 2007-2008 (GSHS-Lara 2008). It explores, among other things, a general violence indicator such as school absenteeism due to feeling unsafe at school or on the way to or from school for any reason; and more specific indicators of violence such as robbery, bullying, physical fights and use of weapons, as well as exposure to lectures on how to prevent violence. Results are given in terms of prevalence percentage. Results Absenteeism doubled between the two study periods (10.8% to 20.8%). The number of students that were a victim of robbery remained high and without change both outside (14.2% and 14.8%) and inside school (21.7% and 22.0%). The number of victims of bullying was high and increasing (33.4% and 43.6%). Bullying associated with being physically attacked decreased (18.5% to 14.3%). Physical attacks without active participation and not associated with bullying were frequent (21.5%). Physical fighting with active participation prevalence remained high and without change (27.5% and 28.2%). Carrying a weapon almost doubled (4.3% to 7.1%). Less than 65% reported classes for violence prevention. Conclusions The GSHS-Lara shows that violence is an important public health problem that needs to be addressed by the community and its authorities. PMID:22958602

  3. Novel C617Y mutation in the 7th transmembrane segment of luteinizing hormone/choriogonadotropin receptor in a Japanese boy with peripheral precocious puberty.

    PubMed

    Nagasaki, Keisuke; Katsumata, Noriyuki; Ogawa, Yohei; Kikuchi, Toru; Uchiyama, Makoto

    2010-01-01

    Testotoxicosis, also known as familial male-limited precocious puberty, is an autosomal dominant form of gonadotropin-independent precocious puberty caused by heterozygous constitutively activating mutations of the LHCGR gene encoding the luteinizing hormone/choriogonadotropin receptor (LH/CGR). The patient is an 8-year-old boy who started to develop pubic hair and penile enlargement at 6 years of age. The patient had elevated serum testosterone levels, but initially exhibited a prepubertal response of gonadotropins to GnRH, which was followed by central activation of the hypothalamo-pituitary-gonadal axis. The father reported having experienced precocious puberty, and is 158 cm tall. There is no history of short stature and precocious puberty in the family except for the father. The LHCGR gene was analyzed by direct DNA sequencing of amplified PCR products from the patient and his parents. The wild-type and mutant LH/CGRs were transiently expressed in COS-1 cells and cAMP levels in the cells were determined with or without hCG stimulation. Genetic analysis revealed a novel C617Y mutation of the LHCGR gene in the patient and his mother, while his father had no mutations. Functional expression study demonstrated around 15% increase in the basal intracellular cAMP level in cells expressing the mutant LH/CGR compared with that in cells expressing the wild-type receptor. We have reported the first missense C617Y mutation located in the 7th transmembrane segment of LH/CGR causing testotoxicosis. The modest phenotype of our patient may be explained, at least in part, by the modest increase in the intracellular cAMP level caused by the C617Y mutation. PMID:21060208

  4. Toward A Feminist Transformation of the Academy: III. Proceedings of the Annual GLCA Women's Studies Conference (7th, November 6-8, 1981).

    ERIC Educational Resources Information Center

    Reed, Beth, Ed.; And Others

    Ten selected papers and a panel discussion are included in these conference proceedings. The first paper is entitled "The Emergence of Women in Twentieth-Century Chilean History and Literature" (Caroline Richards). The second paper is "Attitudes Toward Gender in Two Cultures: Puerto Rico and the United States" (Margaret Berrio, Maria Fernandez,…

  5. From 200 BC to 2015 AD: an integration of robotic surgery and Ayurveda/Yoga

    PubMed Central

    Pillai, Geethakrishnan Gopalakrishna

    2016-01-01

    Background Among the traditional systems of medicine practiced all over the world, Ayurveda and Yoga has a documented history dating back to beyond 200 BC. Robotic and video assisted thoracic surgery (VATS) is an invention of the 21st century. We aim to quantify the effects of integration of Ayurveda and Yoga on patients undergoing minimally invasive robotic and VATS. Methods Four hundred and fifty-four patients undergoing VATS and robotic thoracic surgery were introduced to a pre and postoperative protocol of Yoga therapy, mediation and oil massages. Yoga exercises included Pranayam, Anulom Vilom, and Oil Massages included Urotarpan. Preoperative and postoperative respiratory functions were recorded. Patient satisfaction questionnaire were noted. Statistical comparison was made to control group undergoing minimally invasive thoracic surgery without integrative medicine. Only one patient refused to undergo Ayurveda therapy and was deleted from the group. Results Acceptability was high among all patients. Preoperative training led to implementation as early as 6 hours post surgery. Pulmonary function test showed significant improvement. All patients suggested an improvement in satisfaction score. Pain score were less in study patients. Quicker mobilization led to early discharge and drain removal. Chronic pain was prevented in patients having oil massages over the healed wound sites. Conclusions Integration of Ayurveda, Yoga and minimally invasive robotic and VATS is acceptable to Indian patients and gives better clinical results and higher patient satisfaction. PMID:26941975

  6. Leather material found on a 6th B.C. Chinese bronze sword: a technical study.

    PubMed

    Luo, Wugan; Si, Yi; Wang, Hongmin; Qin, Ying; Huang, Fengchun; Wang, Changsui

    2011-09-01

    During July to November, 2006, an important archaeological excavation was conducted in Yun country, Hubei province, southern China. Chinese archaeologists found some remnant of leather materials, covered with red pigments, on a 6th century B.C. Chinese bronze sword. To understand the technology/ies that may have been utilized for manufacturing the leathers, a combined of Raman spectroscopy, FT-IR and XRF was thus applied to the remnant of leather materials. Raman analyses showed that red pigment on the leather was cinnabar (HgS). FT-IR and XRF analyses indicated that the content of some elements, such as Ca (existing as CaCO3) and Fe (existing as Fe2O3), were much higher than those in the surrounding grave soil. The results inferred an application of lime depilation and retting, and the Fe-Al compound salt as tanning agent. And it was furthermore implicated that the Fe-Al salt tanning technique had been developed in the middle and late Spring and Autumn Period of China. PMID:21703919

  7. Leather material found on a 6th B.C. Chinese bronze sword: A technical study

    NASA Astrophysics Data System (ADS)

    Luo, Wugan; Si, Yi; Wang, Hongmin; Qin, Ying; Huang, Fengchun; Wang, Changsui

    2011-09-01

    During July to November, 2006, an important archaeological excavation was conducted in Yun country, Hubei province, southern China. Chinese archaeologists found some remnant of leather materials, covered with red pigments, on a 6th century B.C. Chinese bronze sword. To understand the technology/ies that may have been utilized for manufacturing the leathers, a combined of Raman spectroscopy, FT-IR and XRF was thus applied to the remnant of leather materials. Raman analyses showed that red pigment on the leather was cinnabar (HgS). FT-IR and XRF analyses indicated that the content of some elements, such as Ca (existing as CaCO 3) and Fe (existing as Fe 2O 3), were much higher than those in the surrounding grave soil. The results inferred an application of lime depilation and retting, and the Fe-Al compound salt as tanning agent. And it was furthermore implicated that the Fe-Al salt tanning technique had been developed in the middle and late Spring and Autumn Period of China.

  8. The Merger of White Ovals BC and DE

    NASA Astrophysics Data System (ADS)

    Beebe, A. A.

    1998-09-01

    In early 1998 it was reported by amateur observers, and confirmed by IRTF and Pic-du-Midi observations, that two of Jupiter's classical White Ovals, BC and DE, had merged (IAU circ. #6942). 5 orbits of Hubble Space Telescope Target of Opportunity WFPC2 observations were granted for June 3, 1998 and July 16, 1998 to observe the post-merger state of the oval region. Preliminary analysis of the remaining ovals over a range of incident and emergent light angles sets limits on the morphology, rotational velocities and translation rates and characterizes the surrounding zonal structure. In the context of historical observations, the ovals appear to be behaving in a manner similar to that seen whenever ovals have interacted. There has been an acceleration of the new oval, which is now gradually decelerating as it experiences drag from its surroundings. Qualitatively, the new oval's morphology and structure in a wide range of filters (410 to 953 nm) is similar to the pre-merger structure of BC, indicating that the new oval has a character similar to that of the other White Ovals. The authors wish to acknowledge the observers of the ALPO and the IJW for their diligent efforts in obtaining transit times and images of these events. These results are based on observations with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract No. NAS5-26555.

  9. Biases in modeled surface snow BC mixing ratios in prescribed-aerosol climate model runs

    NASA Astrophysics Data System (ADS)

    Doherty, S. J.; Bitz, C. M.; Flanner, M. G.

    2014-11-01

    Black carbon (BC) in snow lowers its albedo, increasing the absorption of sunlight, leading to positive radiative forcing, climate warming and earlier snowmelt. A series of recent studies have used prescribed-aerosol deposition flux fields in climate model runs to assess the forcing by black carbon in snow. In these studies, the prescribed mass deposition flux of BC to surface snow is decoupled from the mass deposition flux of snow water to the surface. Here we compare prognostic- and prescribed-aerosol runs and use a series of offline calculations to show that the prescribed-aerosol approach results, on average, in a factor of about 1.5-2.5 high bias in annual-mean surface snow BC mixing ratios in three key regions for snow albedo forcing by BC: Greenland, Eurasia and North America. These biases will propagate directly to positive biases in snow and surface albedo reduction by BC. The bias is shown be due to coupling snowfall that varies on meteorological timescales (daily or shorter) with prescribed BC mass deposition fluxes that are more temporally and spatially smooth. The result is physically non-realistic mixing ratios of BC in surface snow. We suggest that an alternative approach would be to prescribe BC mass mixing ratios in snowfall, rather than BC mass fluxes, and we show that this produces more physically realistic BC mixing ratios in snowfall and in the surface snow layer.

  10. Preparation and characterization of BC/PAM-AgNPs nanocomposites for antibacterial applications.

    PubMed

    Yang, Guang; Wang, Caixia; Hong, Feng; Yang, Xuexia; Cao, Zhangjun

    2015-01-22

    In this work, a bacterial cellulose/polyacrylamide (BC/PAM) double network composite was prepared to act as the template for in situ synthesis of silver nanoparticles (AgNPs). Effects of reaction conditions of the BC/PAM composite were investigated on its microstructure, mechanical properties and thermal stabilities. Both the BC/PAM composite and pure BC were utilized to prepare the corresponding silver impregnated nanocomposites, i.e., BC/PAM-AgNPs and BC-AgNPs, by an environmental friendly method, UV irradiation. The influences of the templates were investigated on the AgNPs formation and the antibacterial activities of the nanocomposites by both the zone of inhibition and dynamic shake flask methods. It was shown that the BC/PAM composite displayed a denser microstructure and higher thermal stabilities than pure BC. The BC/PAM-AgNPs nanocomposite exhibited a bigger particle size and lower mass content of AgNPs than the BC-AgNPs one. For the antibacterial test, two nanocomposites exhibited a close antibacterial effect, with a high log reduction above 3 and killing ratio above 99.9%, respectively. PMID:25439942

  11. Downregulation of BC200 in ovarian cancer contributes to cancer cell proliferation and chemoresistance to carboplatin

    PubMed Central

    WU, DI; WANG, TIANZHEN; REN, CHENGCHENG; LIU, LEI; KONG, DAN; JIN, XIAOMING; LI, XIAOBO; ZHANG, GUANGMEI

    2016-01-01

    Previous studies have demonstrated that long non-coding RNAs (lncRNAs) serve an important role in carcinogenesis. BC200 is a lncRNA that is reportedly associated with ovarian cancer. The aim of the present study was to investigate this potential association between BC200 and ovarian cancer, and to subsequently analyze the biological function of BC200 in the disease. BC200 expression was compared in ovarian cancer tissue and normal ovarian tissue samples through the use of quantitative polymerase chain reaction. To allow the biological function of BC200 in ovarian cancer to be analyzed, small interfering RNA was used to knock down the expression of BC200 in SKOV3 and A2780 ovarian cancer cells. The proliferative, invasive and migratory abilities of the cells were identified by means of cell counting kits and Transwell assays. Carboplatin was also used to treat the ovarian cancer cells, and a luminescent cell viability assay was subsequently used to detect the sensitivity of the cells to the carboplatin. The results demonstrated that BC200 expression was reduced in ovarian cancer compared with normal ovarian tissue samples. In the SKOV3 and A2780 cells, BC200 exerted no effect on invasive or migratory ability, however, the inhibition of BC200 was demonstrated to promote cell proliferation. Additionally, it was observed that carboplatin induced BC200 expression in the cell lines, and that the inhibition of BC200 decreased the sensitivity of the cells to the drug. BC200 is therefore likely to have a tumor suppressive function in ovarian cancer by affecting cell proliferation. Furthermore, BC200 appears to serve a role in the mediation of carboplatin-induced ovarian cancer cell death. PMID:26893717

  12. Phase transition in BC[subscript x] system under high-pressure and high-temperature: Synthesis of cubic dense BC[subscript 3] nanostructured phase

    SciTech Connect

    Zinin, P.V.; Ming, L.C.; Ishii, H.A.; Jia, R.; Acosta, T.; Hellebrand, E.

    2012-07-11

    We synthesized a cubic BC{sub 3} (c-BC{sub 3}) phase, by direct transformation from graphitic phases at a pressure of 39 GPa and temperature of 2200 K in a laser-heated diamond anvil cell. A combination of x-ray diffraction, electron diffraction, transmission electron microscopy (TEM) imaging, and electron energy loss spectroscopy (EELS) measurements lead us to conclude that the obtained phase is hetero-nano-diamond, c-BC{sub 3}. High-resolution TEM imaging of the c-BC{sub 3} specimen recovered at ambient conditions demonstrates that the c-BC{sub 3} is a single, uniform, nanocrystalline phase with a grain size of about 3-5 nm. The EELS measurements show that the atoms inside the cubic structure are bonded by sp{sup 3} bonds. The zero-pressure lattice parameter of the c-BC{sub 3} calculated from diffraction peaks was found to be a = 3.589 {+-} 0.007 {angstrom}. The composition of the c-BC{sub 3} is determined from EELS measurements. The ratio of carbon to boron, C/B, is approximately 3 (2.8 {+-} 0.7).

  13. A Multi-Layer Phoswich Radioxenon Detection System (7th Qtr Report), Reporting Period 10/01/07 - 12/31/07

    SciTech Connect

    David M. Hamby

    2008-01-29

    Description of activities conducted this report period: (1) Electronics Development--To improve the overall performance of the two-channel digital pulse processor (DPP2), the PCB has been redesigned and the new printed board is now under assembly. The system is enhanced with two new fast ADCs from Analog Devices (AD9230-250), each with a sampling rate of 250 MHz and a resolution of 12 bits. The data bus uses a high performance Low Voltage Differential Signaling (LVDS) standard. The offset and gain of each channel are separately controlled digitally by the GUI software. (2) GUI Software Development--A GUI is being developed using the Python programming language. All functions from the preceding MATLAB code have been re-implemented including basic waveform readout, pulse shape discrimination, and plotting of energy spectra. In addition, the GUI can be used to control sampling runs based on the number of pulses captured, either in real or live time. Calibration coefficients and pulse shape discrimination boundaries can be changed on the fly so that the detector may be characterized experimentally. Plots generated by the GUI can be exported as graphic data. At present, the software has only been tested using one channel, pending availability of the new DPP board (DPP2). However, the functions have been written to allow easy expansion to two channels. (3) Light Collection Modeling--The XEPHWICH design has been modeled to determine its light capture efficiency. Research in the 7th quarter includes additional simulations representing significant increase in data resolution, well over an order of magnitude greater than previous simulations. The final data set represents approximately 11 billion visible photons divided equally among 110 thousand data points. A laboratory experiment is being designed and executed to experimentally determine light capture efficiency as a function of position within the scintillators. (4) Radioxenon Fission Source--We have designed and

  14. Tunable electronic properties induced by a defect-substrate in graphene/BC3 heterobilayers.

    PubMed

    Li, Sheng-shi; Zhang, Chang-wen; Ji, Wei-xiao; Li, Feng; Wang, Pei-ji

    2014-11-01

    We perform first-principles calculations to study the geometric, energetics and electronic properties of graphene supported on BC3 monolayer. The results show that overall graphene interacts weakly with BC3 monolayer via van der Waals interaction. The energy gap of graphene can be up to ∼0.162 eV in graphene/BC3 heterobilayers (G/BC3 HBLs), which is large enough for the gap opening at room temperature. We also find that the interlayer spacing and in-plane strain can tune the band gap of G/BC3 HBLs effectively. Interestingly, the characteristics of a Dirac cone with a nearly linear band dispersion relationship of graphene can be preserved, accompanied by a small electron effective mass, and thus the higher carrier mobility is still expected. These findings provide a possible way to design effective FETs out of graphene on a BC3 substrate. PMID:25241677

  15. BcCluster: A Bladder Cancer Database at the Molecular Level

    PubMed Central

    Bhat, Akshay; Mokou, Marika; Zoidakis, Jerome; Jankowski, Vera; Vlahou, Antonia; Mischak, Harald

    2016-01-01

    Background: Bladder Cancer (BC) has two clearly distinct phenotypes. Non-muscle invasive BC has good prognosis and is treated with tumor resection and intravesical therapy whereas muscle invasive BC has poor prognosis and requires usually systemic cisplatin based chemotherapy either prior to or after radical cystectomy. Neoadjuvant chemotherapy is not often used for patients undergoing cystectomy. High-throughput analytical omics techniques are now available that allow the identification of individual molecular signatures to characterize the invasive phenotype. However, a large amount of data produced by omics experiments is not easily accessible since it is often scattered over many publications or stored in supplementary files. Objective: To develop a novel open-source database, BcCluster (http://www.bccluster.org/), dedicated to the comprehensive molecular characterization of muscle invasive bladder carcinoma. Materials: A database was created containing all reported molecular features significant in invasive BC. The query interface was developed in Ruby programming language (version 1.9.3) using the web-framework Rails (version 4.1.5) (http://rubyonrails.org/). Results: BcCluster contains the data from 112 published references, providing 1,559 statistically significant features relative to BC invasion. The database also holds 435 protein-protein interaction data and 92 molecular pathways significant in BC invasion. The database can be used to retrieve binding partners and pathways for any protein of interest. We illustrate this possibility using survivin, a known BC biomarker. Conclusions: BcCluster is an online database for retrieving molecular signatures relative to BC invasion. This application offers a comprehensive view of BC invasiveness at the molecular level and allows formulation of research hypotheses relevant to this phenotype. PMID:27376128

  16. Impact of cruise ship emissions in Victoria, BC, Canada

    NASA Astrophysics Data System (ADS)

    Poplawski, Karla; Setton, Eleanor; McEwen, Bryan; Hrebenyk, Dan; Graham, Mark; Keller, Peter

    2011-02-01

    Characterization of the effects of cruise ship emissions on local air quality is scarce. Our objective was to investigate community level concentrations of fine particulate matter (PM 2.5), nitrogen dioxide (NO 2) and sulphur dioxide (SO 2) associated with cruise ships in James Bay, Victoria, British Columbia (BC), Canada. Data obtained over four years (2005-2008) at the nearest air quality network site located 3.5 km from the study area, a CALPUFF modeling exercise (2007), and continuous measurements taken in the James Bay community over a three-month period during the 2009 cruise ship season were examined. Concentrations of PM 2.5 and nitrogen oxide (NO) were elevated on weekends with ships present with winds from the direction of the terminal to the monitoring station. SO 2 displayed the greatest impact from the presence of cruise ships in the area. Network data showed peaks in hourly SO 2 when ships were in port during all years. The CALPUFF modeling analysis found predicted 24-hour SO 2 levels to exceed World Health Organization (WHO) guidelines of 20 μg m -3 for approximately 3% of 24-hour periods, with a maximum 24-hour concentration in the community of 41 μg m -3; however, the CALPUFF model underestimated concentrations when predicted and measured concentrations were compared at the network site. Continuous monitoring at the location in the community predicted to experience highest SO 2 concentrations measured a maximum 24-hour concentration of 122 μg m -3 and 16% of 24-hour periods were above the WHO standard. The 10-minute concentrations of SO 2 reached up to 599 μg m -3 and exceeded the WHO 10-minute SO 2 guideline (500 μg m -3) for 0.03% of 10-minute periods. No exceedences of BC Provincial or Canadian guidelines or standards were observed.

  17. First-principles prediction of MgB2-like NaBC: A more promising high-temperature superconducting material than LiBC

    NASA Astrophysics Data System (ADS)

    Miao, Rende; Huang, Guiqin; Yang, Jun

    2016-05-01

    Crystal structure, lattice dynamics, and superconducting properties for sodium borocarbides NaB1+xC1-x are investigated with first-principles calculations. Based on crystal structure analysis by particle swarm optimization methodology, NaBC is predicted to crystallize in the layered P63 / mmc crystal structure as LiBC. However, it is different from LiBC, in that Na atoms are effectively ionized, with no longitudinal covalence exist between Na and B-C layers, just as in the case of MgB2. Therefore, Na1-xBC is more similar to MgB2 than Li1-xBC as a potential high-temperature superconductor. Further more, we suggest that the slight hole doping of NaBC through partial substitution of C by B atoms can also produce cause superconductivity. The phonon spectra for NaBC and NaB1.1C0.9 are obtained within the virtual-crystal approximation treatment. There is a remarkable softening of the in-plane B-C bond-stretching modes for NaB1.1C0.9 in certain regions of the Brillouin zone, while other phonon bands show no obvious softening behavior. This conspicuous softening of the in-plane B-C bond-stretching modes indicates a strong electron-phonon coupling for them. The obtained total electron-phonon coupling strength λ for NaB1.1C0.9 is 0.73, and superconducting transition temperature TC is predicted to be 35 K (μ* = 0.1). This indicates that NaB1+xC1-x is potentially high-temperature superconducting and hole doping of NaBC could produce high-temperature superconductivity. In addition, we conjecture that, to design a MgB2-like high TC superconducting material, the longitudinal covalent bonds between the metal cations and graphite-like layers need be excluded.

  18. Importance of composition and hygroscopicity of BC particles to the effect of BC mitigation on cloud properties: Application to California conditions

    NASA Astrophysics Data System (ADS)

    Bahadur, Ranjit; Russell, Lynn M.; Jacobson, Mark Z.; Prather, Kimberly; Nenes, Athanasios; Adams, Peter; Seinfeld, John H.

    2012-05-01

    Black carbon (BC) has many effects on climate including the direct effect on atmospheric absorption, indirect and semi-direct effects on clouds, snow effects, and others. While most of these are positive (warming), the first indirect effect is negative and quantifying its magnitude in addition to other BC feedbacks is important for supporting policies that mitigate BC. We use the detailed aerosol chemistry parcel model of Russell and Seinfeld (1998), observationally constrained by initial measured aerosol concentrations from five California sites, to provide simulated cloud drop number (CDN) concentrations against which two GCM calculations - one run at the global scale and one nested from the global-to-regional scale are compared. The GCM results reflect the combined effects of their emission inventories, advection schemes, and cloud parameterizations. BC-type particles contributed between 16 and 20% of cloud droplets at all sites even in the presence of more hygroscopic particles. While this chemically detailed parcel model result is based on simplified cloud dynamics and does not consider semi-direct or cloud absorption effects, the cloud drop number concentrations are similar to the simulations of both Chen et al. (2010b) and Jacobson (2010) for the average cloud conditions in California. Reducing BC particle concentration by 50% decreased the cloud droplet concentration by between 6% and 9% resulting in the formation of fewer, larger cloud droplets that correspond to a lower cloud albedo. This trend is similar to Chen et al. (2010b) and Jacobson (2010) when BC particles were modeled as hygroscopic. This reduction in CDN in California due to the decrease in activated BC particles supports the concern raised by Chen et al. (2010a) that the cloud albedo effect of BC particles has a cooling effect that partially offsets the direct forcing reduction if other warming effects of BC on clouds are unchanged. These results suggests that for regions like the California

  19. EDITORIAL: The 7th International Workshop on Micro and Nanotechnologies for Power Generation and Energy Conversion Applications (PowerMEMS 2007)

    NASA Astrophysics Data System (ADS)

    Hebling, C.; Woias, P.

    2008-10-01

    This special issue of Journal of Micromechanics and Microengineering (JMM) contains a selection of papers from the 7th International Workshop on Micro and Nanotechnologies for Power Generation and Energy Conversion (PowerMEMS 2007). The workshop was held in Freiburg, Germany on 27-29 November 2007 under the joint organization of the Fraunhofer Institute for Solar Energy Systems (FhG-ISE), Freiburg and the Department of Microsystems Engineering (IMTEK) of the Albert-Ludwig-University of Freiburg. PowerMEMS 2007 continues a series of workshops initiated in 2000 in Japan to create an annual discussion forum in the emerging field of micro energy technology. With a single exception in 2001, the workshop has continued as an annual meeting ever since, with a continuous increase in the number of presentations and participants. The program of PowerMEMS 2007 was composed of 2 invited talks, 25 oral talks and 61 poster presentations. From these 88 presentations 16 have been selected for this special issue. It was at the end of 1959 when the Caltech physicist Richard Feynman gave his famous lecture entitled 'There Is Plenty of Room at the Bottom' in which he discussed the possibilities of miniaturization for both storage capacity ('Encyclopaedia Britannica on the head of a pin') as well as micro machining ('rearranging the atoms'), although there were absolutely no technological possibilities in sight for an adequate realization of such ideas. Now, nearly 50 years later, we not only have incredible knowledge about the nanoworld, but even more we are now able to generate microelectromechanical devices which, next to their electronic properties, can integrate physical and analytical functions. Today, Feynman might easily have added a second lecture entitled 'There is Plenty of Energy at the Bottom'. Micro energy technology has seen a tremendous rise in MEMS and material sciences and is regarded today as one of their hot topics. Also, there are more and more companies in this

  20. Changes in Arctic black carbon concentrations, deposition, transport, and sources during recent centuries

    NASA Astrophysics Data System (ADS)

    McConnell, J. R.; Dahl-Jensen, D.; Flanner, M. G.; Fritzsche, D.; Kreutz, K. J.; Lamarque, J.; Lawrence, R.; Maselli, O.; Nolan, M.; Opel, T.; Pasteris, D.; Sigl, M.; Steffensen, J.

    2011-12-01

    Rates of climate change in the Arctic are among the highest on Earth. Warming from increased carbon dioxide and other greenhouse gas concentrations is the long-term driver of Arctic climate change, but reductions in short-lived aerosols such as black carbon (BC) that contribute to climate warming offer the possibility of slowing Arctic climate change in the near-term. BC in snow and water is especially important to climate forcing in the Arctic because of its impact on albedo. Detailed understanding of past and present concentrations, deposition rates, sources, and transport pathways of BC to and within the Arctic is critical, however, to the design of effective mitigation policies. With their short lifetimes in the atmosphere, aerosol concentrations and deposition in the Arctic are dominated by regional, rather than global, sources, transport processes, and pathways. Such aerosols consist of continental dust, sea spray, particulates including BC and organic matter from combustion processes, sulfur and trace metals from volcanic emissions, and, during recent centuries, industrial activities. Further, intra- and inter-annual variability of aerosol deposition is large. As a result, spatially distributed measurements of historical, high-time-resolution records with a broad range of analytes are required to understand aerosol concentrations, sources, and variability while providing adequate information for evaluating global circulation, snowpack radiation, and other modeling results. Arrays of ice cores from polar and alpine glaciers and ice sheets offer the potential to provide spatially distributed historical records with very high time resolution and a broad spectrum of aerosols and source tracers, particularly when using a continuous flow analytical system. Here we present and discuss recent findings from measurements of BC and related source tracers in a developing array of ice cores from around the Arctic. We use 1850 to 2000 general circulation modeling to

  1. New Members' Resource Book: A Reference for Institutions New to the BC Transfer System

    ERIC Educational Resources Information Center

    Finlay, Finola

    2011-01-01

    This resource book is a reference for new member institutions which are those private institutions admitted to the BC Transfer System by way of having one or more programs reviewed by the Degree Quality Assessment Board and given Minister's Consent. All current BC Transfer System members and prospective members (private institutions contemplating…

  2. Mobility of BC Transfer Students -- Fall 2006 to Calendar Year 2007. Research Summary

    ERIC Educational Resources Information Center

    Heslop, Joanne

    2008-01-01

    These research highlights summarize the movement of transfer students from British Columbia (BC) colleges, university colleges, and institutes (sending Institutions) into BC universities from the Fall of 2006 into calendar year 2007. Predictions for 2008 are also provided along with trends from Fall 2003 to the present. Transfer students are…

  3. Mobility of BC Transfer Students--Fall 2006 to Calendar Year 2007. Research Results

    ERIC Educational Resources Information Center

    Heslop, Joanne

    2008-01-01

    This newsletter summarizes the movement of transfer students from British Columbia (BC) colleges, university colleges, and institutes (sending Institutions) into BC universities from the Fall of 2006 into calendar year 2007. Predictions for 2008 are also provided along with trends from Fall 2003 to the present. Transfer students are classified…

  4. Evaluating BC and NOx emission inventories for the Paris region from MEGAPOLI aircraft measurements

    NASA Astrophysics Data System (ADS)

    Petetin, H.; Beekmann, M.; Colomb, A.; Denier van der Gon, H. A. C.; Dupont, J.-C.; Honoré, C.; Michoud, V.; Morille, Y.; Perrussel, O.; Schwarzenboeck, A.; Sciare, J.; Wiedensohler, A.; Zhang, Q. J.

    2015-09-01

    High uncertainties affect black carbon (BC) emissions, and, despite its important impact on air pollution and climate, very few BC emissions evaluations are found in the literature. This paper presents a novel approach, based on airborne measurements across the Paris, France, plume, developed in order to evaluate BC and NOx emissions at the scale of a whole agglomeration. The methodology consists in integrating, for each transect, across the plume observed and simulated concentrations above background. This allows for several error sources (e.g., representativeness, chemistry, plume lateral dispersion) to be minimized in the model used. The procedure is applied with the CHIMERE chemistry-transport model to three inventories - the EMEP inventory and the so-called TNO and TNO-MP inventories - over the month of July 2009. Various systematic uncertainty sources both in the model (e.g., boundary layer height, vertical mixing, deposition) and in observations (e.g., BC nature) are discussed and quantified, notably through sensitivity tests. Large uncertainty values are determined in our results, which limits the usefulness of the method to rather strongly erroneous emission inventories. A statistically significant (but moderate) overestimation is obtained for the TNO BC emissions and the EMEP and TNO-MP NOx emissions, as well as for the BC / NOx emission ratio in TNO-MP. The benefit of the airborne approach is discussed through a comparison with the BC / NOx ratio at a ground site in Paris, which additionally suggests a spatially heterogeneous error in BC emissions over the agglomeration.

  5. Evaluating BC and NOx emission inventories for the Paris region from MEGAPOLI aircraft measurements

    NASA Astrophysics Data System (ADS)

    Petetin, H.; Beekmann, M.; Colomb, A.; Denier van der Gon, H. A. C.; Dupont, J.-C.; Honoré, C.; Michoud, V.; Morille, Y.; Perrussel, O.; Schwarzenboeck, A.; Sciare, J.; Wiedensohler, A.; Zhang, Q. J.

    2014-11-01

    High uncertainties affect black carbon (BC) emissions and, despite its important impact on air pollution and climate, very few BC emissions evaluations are found in the literature. This paper presents a novel approach, based on airborne measurements across the Paris plume, developed in order to evaluate BC and NOx emissions at the scale of a whole agglomeration. The methodology consists in integrating, for each transect, across the plume observed and simulated concentrations above background. This allows minimizing several error sources in the model (e.g. representativeness, chemistry, plume lateral dispersion). The procedure is applied with the CHIMERE chemistry-transport model to three inventories - the EMEP inventory, and the so-called TNO and TNO-MP inventories - over the month of July 2009. Various systematic uncertainty sources both in the model (e.g. boundary layer height, vertical mixing, deposition) and in observations (e.g. BC nature) are discussed and quantified, notably though sensitivity tests. A statistically significant (but moderate) overestimation is obtained on the TNO BC emissions and on EMEP and TNO-MP NOx emissions, as well as on the BC/NOx emission ratio in TNO-MP. The benefit of the airborne approach is discussed through a comparison with the BC/NOx ratio at a ground site in Paris, which additionally suggests potential error compensations in the BC emissions spatial distribution over the agglomeration.

  6. BC measurement activities at the U.S. Environmental Protection Agency

    EPA Science Inventory

    Black carbon (BC)--sometimes referred to as soot, char, or elemental carbon (EC)--is a refractory form of light-absorbing carbon produced from incomplete combustion. Accurate measurement of BC in combustion source emissions is important for understanding anthropogenic climate for...

  7. Bacterial cellulose based hydrogel (BC-g-AA) and preliminary result of swelling behavior

    NASA Astrophysics Data System (ADS)

    Hakam, Adil; Lazim, Azwan Mat; Abdul Rahman, I. Irman

    2013-11-01

    In this study, hydrogel based on Bacterial cellulose (BC) or local known as Nata de Coco, which grafted with monomer: Acrylic acid (AA) is synthesis by using gamma radiation technique. These hydrogel (BC-g-AA) has unique characteristic whereby responsive to pH buffer solution.

  8. Body-centered superhard BC2N phases from first principles

    NASA Astrophysics Data System (ADS)

    Luo, Xiaoguang; Guo, Xiaoju; Xu, Bo; Wu, Qinghua; Hu, Qianku; Liu, Zhongyuan; He, Julong; Yu, Dongli; Tian, Yongjun; Wang, Hui-Tian

    2007-09-01

    Body-centered BC2N deduced from the unit cell of the recently predicted body-centered carbon [F. J. Ribeiro , Phys. Rev. B 74, 172101 (2006)] are studied with first-principles pseudopotential density functional method. The structural, electronic, and mechanical properties are investigated for 11 possible atomic configurations of body-centered BC2N . Our results show that the sp3 -bonded body-centered BC2N phases have lower density than the previously investigated sp3 -bonded zinc-blende BC2N , wurtzite BC2N , and chalcopyrite BC2N . The struc-A and struc-B composed of the maximum numbers of C-C and B-N bonds have the lowest total energy among the investigated body-centered BC2N structures. Their calculated bulk moduli are 305 and 309GPa , respectively. The theoretical Vickers hardness of the body-centered BC2N is over 60GPa , indicating that it is a potential superhard material with the hardness comparable to cubic boron nitride.

  9. P.E.O.P.L.E. 32: B.C. College Region Population Projections

    ERIC Educational Resources Information Center

    Ministry of Advanced Education and Labour Market Development, 2007

    2007-01-01

    Each year BC Stats, Ministry of Labour and Citizens' Services, projects the population of British Columbia (BC) and its regions. These projections are based on assumptions about future fertility, mortality and migration levels. Assumptions are derived from demographic trends modified to include potential impacts of future economic factors. The…

  10. Opening Minds behind Closed Doors: Literacy in B.C. Corrections. A Research Report.

    ERIC Educational Resources Information Center

    Thomas, Audrey M.

    A project examined perspectives of offenders in adult correctional facilities in British Columbia (B.C.) in relation to their literacy needs and how and where those needs were being met. Information was gathered through a series of questionnaires sent to Directors of Correctional Centers in B.C., adult basic education (ABE) administrators with…

  11. Bacterial cellulose based hydrogel (BC-g-AA) and preliminary result of swelling behavior

    SciTech Connect

    Hakam, Adil; Lazim, Azwan Mat; Abdul Rahman, I. Irman

    2013-11-27

    In this study, hydrogel based on Bacterial cellulose (BC) or local known as Nata de Coco, which grafted with monomer: Acrylic acid (AA) is synthesis by using gamma radiation technique. These hydrogel (BC-g-AA) has unique characteristic whereby responsive to pH buffer solution.

  12. 46 CFR 7.150 - Canadian (BC) and United States (AK) Borders to Cape Spencer, AK.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Canadian (BC) and United States (AK) Borders to Cape Spencer, AK. 7.150 Section 7.150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Alaska § 7.150 Canadian (BC) and United States (AK) Borders to...

  13. 46 CFR 7.150 - Canadian (BC) and United States (AK) Borders to Cape Spencer, AK.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Canadian (BC) and United States (AK) Borders to Cape Spencer, AK. 7.150 Section 7.150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Alaska § 7.150 Canadian (BC) and United States (AK) Borders to...

  14. Long-Term Fluctuations in the Earth's Rotation: 700 BC to AD 1990

    NASA Astrophysics Data System (ADS)

    Stephenson, F. R.; Morrison, L. V.

    1995-04-01

    Records of solar and lunar eclipses in the period 700 BC to AD 1600, originating from the ancient and medieval civilizations of Babylon, China, Europe and the Arab world, are amassed and critically appraised for their usefulness in answering questions about the long-term variability of the Earth's rate of rotation. Results from previous analyses of lunar occultations in the period AD 1600-1955.5, and from high-precision data in AD 1955.5-1990, are included in the dataset considered in this paper. Using the change in the length of the mean solar day (l.o.d.) in units of milliseconds per century (ms cy-1) as the measure of acceleration in the rate of rotation, it is found that the l.o.d. has increased by (+1.70 ± 0.05) ms cy-1 (equiv (-4.5 ± 0.1) × 10-22 rad s-2) on average over the past 2700 years. Yet an increase of +2.3 ± 0.1 ms cy-1 (equiv (-6.1 ± 0.4) × 10-22 rad s-2) is expected from the tidal braking of the Earth's spin, assuming a value of -26.0' ' cy-2 for the tidal acceleration of the Moon. There is thus an average accelerative component in the Earth's rotation which acts to decrease the l.o.d. by (-0.6 ± 0.1) ms cy-1 (equiv (+1.6 ± 0.4) × 10-22 rad s-2). Moreover, it is shown that besides this accelerative component, there is a fluctuation in the l.o.d. with a semi-amplitude of ~ 4 ms and a period of ~ 1500 yr.

  15. Climatic changes and social transformations in the Near East and North Africa during the 'long' 4th millennium BC: A comparative study of environmental and archaeological evidence

    NASA Astrophysics Data System (ADS)

    Clarke, Joanne; Brooks, Nick; Banning, Edward B.; Bar-Matthews, Miryam; Campbell, Stuart; Clare, Lee; Cremaschi, Mauro; di Lernia, Savino; Drake, Nick; Gallinaro, Marina; Manning, Sturt; Nicoll, Kathleen; Philip, Graham; Rosen, Steve; Schoop, Ulf-Dietrich; Tafuri, Mary Anne; Weninger, Bernhard; Zerboni, Andrea

    2016-03-01

    This paper explores the possible links between rapid climate change (RCC) and social change in the Near East and surrounding regions (Anatolia, central Syria, southern Israel, Mesopotamia, Cyprus and eastern and central Sahara) during the 'long' 4th millennium (∼4500-3000) BC. Twenty terrestrial and 20 marine climate proxies are used to identify long-term trends in humidity involving transitions from humid to arid conditions and vice versa. The frequency distribution of episodes of relative aridity across these records is calculated for the period 6300-2000 BC, so that the results may be interpreted in the context of the established arid episodes associated with RCC around 6200 and 2200 BC (the 8.2 and 4.2 kyr events). We identify two distinct episodes of heightened aridity in the early-mid 4th, and late 4th millennium BC. These episodes cluster strongly at 3600-3700 and 3100-3300 BC. There is also evidence of localised aridity spikes in the 5th and 6th millennia BC. These results are used as context for the interpretation of regional and local archaeological records with a particular focus on case studies from western Syria, the middle Euphrates, southern Israel and Cyprus. Interpretation of the records involves the construction of plausible narratives of human-climate interaction informed by concepts of adaptation and resilience from the literature on contemporary (i.e. 21st century) climate change and adaptation. The results are presented alongside well-documented examples of climatically-influenced societal change in the central and eastern Sahara, where detailed geomorphological studies of ancient environments have been undertaken in tandem with archaeological research. While the narratives for the Near East and Eastern Mediterranean remain somewhat speculative, the use of resilience and adaptation frameworks allows for a more nuanced treatment of human-climate interactions and recognises the diversity and context-specificity of human responses to climatic

  16. Hexagonal BC3 as a Robust Electrode Material for Li, Na, and K Ion Batteries

    NASA Astrophysics Data System (ADS)

    Joshi, Rajendra; Ozdemir, Burak; Peralta, Juan; Barone, Veronica

    We propose hexagonal BC3 as a robust electrode material for Li, Na, and K ion batteries based on first-principles density functional theory calculations. We show that, by intercalating Li, Na, and K in BC3, it is possible to form Li1.5BC3, Na1BC3, and K1.5BC3 which correspond to a high theoretical capacity of 858 mA h/g, 572 mA h/g, 858 mA h/g, respectively. In addition, this material presents small open circuit voltage variations of 0.49, 0.12, and 0.16 V when used as electrode for Li, Na, and K ion batteries, respectively. NSF CBET-1335944, NSF DMR-0906617, DOE DE-FG02-10ER16203.

  17. Genome sequences of Alicycliphilus denitrificans strain BC and K601(T)

    SciTech Connect

    Oosterkamp, Margreet J.; Veuskens, Teun; Plugge, Caroline M.; Langenhoff, A. M.; Gerritse, Jan; Van Berkel, Willem J. H.; Pieper, Dietmar; Junca, Howard; Goodwin, Lynne A.; Daligault, Hajnalka E.; Bruce, David; Detter, J. Chris; Tapia, Roxanne; Han, Cliff; Land, Miriam L; Hauser, Loren John; Smidt, Hauke; Stams, Alfons J. M.

    2011-01-01

    Alicycliphilus denitrificans strain BC and A. denitrificans strain K601T degrade cyclic hydrocarbons. These strains have been isolated from a mixture of wastewater treatment plant material and benzene-polluted soil and from a wastewater treatment plant, respectively, suggesting their role in bioremediation of soil and water. Although the strains are phylogenetically closely related, there are some clear physiological differences. The hydrocarbon cyclohexanol, for example, can be degraded by strain K601T but not by strain BC. Furthermore, both strains can use nitrate and oxygen as an electron acceptor, but only strain BC can use chlorate as electron acceptor. To better understand the nitrate and chlorate reduction mechanisms coupled to the oxidation of cyclic compounds, the genomes of A. denitrificans strains BC and K601T were sequenced. Here, we report the complete genome sequences of A. denitrificans strains BC and K601T.

  18. Response of BC418 Plastic Scintillator to Low Energy Protons

    NASA Astrophysics Data System (ADS)

    Daub, B. H.; Henzl, V.; Kovash, M. A.; Matthews, J. L.; Miller, Z. W.; Shoniyozov, K.; Yang, H.

    2012-10-01

    The response of fast plastic scintillators is unknown for proton energies below approximately 300 keV. The response of BC418 plastic scintillator to protons from 100 keV to 3.6 MeV was measured using elastic scattering of neutrons at the University of Kentucky and at the Los Alamos Neutron Science Center. At Kentucky, protons of precise energies from a Van de Graaff accelerator impinged on a thin LiF target to produce neutrons in narrow energy bands. At Los Alamos, neutrons were produced from a tungsten spallation source and their energies determined by time of flight. In both experiments a coincidence was detected between the recoiling proton in the plastic scintillator and the elastically scattered neutron in a liquid scintillator. The energy of the recoil proton is determined by the elastic scattering kinematics, with the scattered neutron energy precisely determined by time of flight. The results are compared with previous measurements of the response of similar plastic scintillators in the energy region where they overlap.

  19. PREFACE PASREG: The 7th International Workshop on the Processing and Applications of Superconducting (RE)BCO Large Grain Materials (Washington DC, 29-31 July 2010) PASREG: The 7th International Workshop on the Processing and Applications of Superconducting (RE)BCO Large Grain Materials (Washington DC, 29-31 July 2010)

    NASA Astrophysics Data System (ADS)

    Freyhardt, Herbert; Cardwell, David; Strasik, Mike

    2010-12-01

    Large grain, (RE)BCO bulk superconductors fabricated by top seeded melt growth (TSMG) are able to generate large magnetic fields compared to conventional, iron-based permanent magnets. Following 20 years of development, these materials are now beginning to realize their considerable potential for a variety of engineering applications such as magnetic separators, flywheel energy storage and magnetic bearings. MgB2 has also continued to emerge as a potentially important bulk superconducting material for engineering applications below 20 K due to its lack of granularity and the ease with which complex shapes of this material can be fabricated. This issue of Superconductor Science and Technology contains a selection of papers presented at the 7th International Workshop on the Processing and Applications of Superconducting (RE)BCO Large Grain Materials, including MgB2, held 29th-31sy July 2010 at the Omni Shoreham Hotel, Washington DC, USA, to report progress made in this field in the previous three year period. The workshop followed those held previously in Cambridge, UK (1997), Morioka, Japan (1999), Seattle, USA (2001), Jena, Germany (2003), Tokyo, Japan (2005) and again in Cambridge, UK (2007). The scope of the seventh PASREG workshop was extended to include processing and characterization aspects of the broader spectrum of bulk high temperature superconducting (HTS) materials, including melt-cast Bi-HTS and bulk MgB2, recent developments in the field and innovative applications of bulk HTS. A total of 38 papers were presented at this workshop, of which 30 were presented in oral form and 8 were presented as posters. The organizers wish to acknowledge the efforts of Sue Butler of the University of Houston for her local organization of the workshop. The eighth PASREG workshop will be held in Taiwan in the summer of 2012.

  20. New archeointensity data from French Early Medieval pottery production (6th-10th century AD). Tracing 1500 years of geomagnetic field intensity variations in Western Europe

    NASA Astrophysics Data System (ADS)

    Genevey, Agnès; Gallet, Yves; Jesset, Sébastien; Thébault, Erwan; Bouillon, Jérôme; Lefèvre, Annie; Le Goff, Maxime

    2016-08-01

    Nineteen new archeointensity results were obtained from the analysis of groups of French pottery fragments dated to the Early Middle Ages (6th to 10th centuries AD). They are from several medieval ceramic production sites, excavated mainly in Saran (Central France), and their precise dating was established based on typo-chronological characteristics. Intensity measurements were performed using the Triaxe protocol, which takes into account the effects on the intensity determinations of both thermoremanent magnetization anisotropy and cooling rate. Intensity analyses were also carried out on modern pottery produced at Saran during an experimental firing. The results show very good agreement with the geomagnetic field intensity directly measured inside and around the kiln, thus reasserting the reliability of the Triaxe protocol and the relevance of the quality criteria used. They further demonstrate the potential of the Saran pottery production for archeomagnetism. The new archeointensity results allow a precise and coherent description of the geomagnetic field intensity variations in Western Europe during the Early Medieval period, which was until now poorly documented. They show a significant increase in intensity during the 6th century AD, high intensity values from the 7th to the 9th century, with a minimum of small amplitude at the transition between the 7th and the 8th centuries and finally an important decrease until the beginning of the 11th century. Together with published intensity results available within a radius of 700 km around Paris, the new data were used to compute a master curve of the Western European geomagnetic intensity variations over the past 1500 years. This curve clearly exhibits five intensity maxima: at the transition between the 6th and 7th century AD, at the middle of the 9th century, during the 12th century, in the second part of the 14th century and at the very beginning of the 17th century AD. Some of these peaks are smoothed, or

  1. Antikythera Calculator advances modern science of 19 centuries

    NASA Astrophysics Data System (ADS)

    Pastore, Giovanni

    2010-08-01

    The Greek astronomic calculator, discovered in the depth of the sea in a naval wreckage of the 1st century B.C. in front of the island of Antikythera, is the most amazing among the archaeological discoveries of last century. The mechanism immediately appeared like a device out of its time. After years of study this devise is still provoking a discussion between scientists and archaeologists because of the complexity and the modernity of the scientific knowledge the work presupposes. Its epicyclical gearings show the high level of the scientific culture reached in that period of history. The knowledge of the planetary motion, necessary to the design of the epicyclic gearing of the Calculator of Antikythera, presumes that ancient Greek scientists knew the planetary motion of the celestial bodies and had already achieved the same results that have been attributed to scientists 19 centuries later. The scientific value of this gear mechanism is indisputable because the inventor of the Calculator of Antikythera had the knowledge that was "re-discovered" centuries later as the heliocentric theory proposed by Niccolò Copernicus in 1543 ( De revolutionibus orbium coelestium), the universal gravitation law formulated by Isaac Newton in 1687 ( Philosophiae Naturalis Principia Mathematica), and the kinematic study of the epicyclical gearings published by Robert Willis in 1841 ( Principles of mechanism).

  2. The Human Capital Century.

    ERIC Educational Resources Information Center

    Goldin, Claudia

    2003-01-01

    Reviews public education in the United States during the 20th century through an exploration of the "virtues" of mass education, such as public funding, a practical curriculum, and secular control of schools. Argues that many of these virtues were situational and may now be considered vices. (Contains three graphs.) (WFA)

  3. The Chemical Century

    ERIC Educational Resources Information Center

    Lapp, Ralph E.

    1973-01-01

    Discusses present and future problems of producing clean energy. Graphically presents the changing patterns of fuel use in the United States over the past century, and predicts population growth and energy sources and consumption up to the year 2100 for the United States and the world. (JR)

  4. Suidas (tenth century)

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    Greek encyclopedist. In the course of reading Suidas's Lexicon, EDMOND HALLEY mistakenly connected the naming of the Saros cycle of 223 synodic months by the tenth century Greek lexicographer Suidas with the eclipse cycle of the same period. The solar eclipse cycle is thus now known by the name that Suidas used for another phenomenon. Halley's mistake accounts for the historical confusion that th...

  5. Genome Analysis and Physiological Comparison of Alicycliphilus denitrificans Strains BC and K601T

    PubMed Central

    Talarico Saia, Flávia; Weelink, Sander A. B.; Goodwin, Lynne A.; Daligault, Hajnalka E.; Bruce, David C.; Detter, John C.; Tapia, Roxanne; Han, Cliff S.; Land, Miriam L.; Hauser, Loren J.; Langenhoff, Alette A. M.; Gerritse, Jan; van Berkel, Willem J. H.; Pieper, Dietmar H.; Junca, Howard; Smidt, Hauke; Schraa, Gosse; Davids, Mark; Schaap, Peter J.; Plugge, Caroline M.; Stams, Alfons J. M.

    2013-01-01

    The genomes of the Betaproteobacteria Alicycliphilus denitrificans strains BC and K601T have been sequenced to get insight into the physiology of the two strains. Strain BC degrades benzene with chlorate as electron acceptor. The cyclohexanol-degrading denitrifying strain K601T is not able to use chlorate as electron acceptor, while strain BC cannot degrade cyclohexanol. The 16S rRNA sequences of strains BC and K601T are identical and the fatty acid methyl ester patterns of the strains are similar. Basic Local Alignment Search Tool (BLAST) analysis of predicted open reading frames of both strains showed most hits with Acidovorax sp. JS42, a bacterium that degrades nitro-aromatics. The genomes include strain-specific plasmids (pAlide201 in strain K601T and pAlide01 and pAlide02 in strain BC). Key genes of chlorate reduction in strain BC were located on a 120 kb megaplasmid (pAlide01), which was absent in strain K601T. Genes involved in cyclohexanol degradation were only found in strain K601T. Benzene and toluene are degraded via oxygenase-mediated pathways in both strains. Genes involved in the meta-cleavage pathway of catechol are present in the genomes of both strains. Strain BC also contains all genes of the ortho-cleavage pathway. The large number of mono- and dioxygenase genes in the genomes suggests that the two strains have a broader substrate range than known thus far. PMID:23825601

  6. Genome analysis and physiological comparison of Alicycliphilus denitrificans strains BC and K601T

    SciTech Connect

    Oosterkamp, Margreet J.; Veuskens, Teun; Saia, Flavia Talarico; Weelink, Sander A.B.; Goodwin, Lynne A.; Daligault, Hajnalka E.; Bruce, David; Detter, J. Chris; Tapia, Roxanne; Han, Cliff; Land, Miriam L; Hauser, Loren John; Langenhoff, A. M.; Gerritse, Jan; Van Berkel, Willem J. H.; Pieper, Dietmar; Junca, Howard; Smidt, Hauke; Schraa, Gosse; Davids, Mark; Schaap, Peter J; Plugge, Caroline M.; Stams, Alfons J. M.

    2013-01-01

    The genomes of the Betaproteobacteria Alicycliphilus denitrificans strains BC and K601T have been sequenced to get insight into the physiology of the two strains. Strain BC degrades benzene with chlorate as electron acceptor. The cyclohexanol-degrading denitrifying strain K601T is not able to use chlorate as electron acceptor, while strain BC cannot degrade cyclohexanol. The 16S rRNA sequences of strains BC and K601T are identical and the fatty acid methyl ester patterns of the strains are similar. Basic Local Alignment Search Tool (BLAST) analysis of predicted open reading frames of both strains showed most hits with Acidovorax sp. JS42, a bacterium that degrades nitro-aromatics. The genomes include strain-specific plasmids (pAlide201 in strain K601T and pAlide01 and pAlide02 in strain BC). Key genes of chlorate reduction in strain BC were located on a 120 kb megaplasmid (pAlide01), which was absent in strain K601T. Genes involved in cyclohexanol degradation were only found in strain K601T. Benzene and toluene are degraded via oxygenase-mediated pathways in both strains. Genes involved in the meta-cleavage pathway of catechol are present in the genomes of both strains. Strain BC also contains all genes of the ortho-cleavage pathway. The large number of mono- and dioxygenase genes in the genomes suggests that the two strains have a broader substrate range than known thus far.

  7. Report on Modifications to the BX12 and BX13 BC1 Dipoles

    SciTech Connect

    Welch, James; DeBarge, S.; Emma, P.; Fisher, A.; Li, N.; Wu, J.; /SLAC

    2010-11-23

    Emittance growth seen during the last commissioning run in the bunch compressor optics section, BC1, was blamed on inadequate dipole field quality. The significant linear and nonlinear field non-uniformities generated large horizontal dispersion errors beyond BC1. The linear dispersion after BC1 was corrected using two small 'corrector' quadrupoles placed in BC1 for this purpose, but the remaining nonlinear field caused growth of the normalized horizontal emittance of 40% or more. At best {gamma}{epsilon}{sub x} went from 1.2 {micro}m before BC1 up to 1.7 {micro}m after BC1. The problem was magnified by the larger-than-design energy spread in BC1 due to a long initial bunch length. To improve the field quality we decided to modify the two 'inner dipoles', BX12 and BX13, of the four magnet chicane during the four month down time in the Fall of 2007. Only the two inner dipoles were chosen because of the limited time available and the fact that the beam is particularly sensitive to field quality of the inner dipoles due to its very large transverse size when going through them. The modifications were completed in November and included new poles and a new pinning scheme. The outer dipoles were left unchanged.

  8. The Hospital Microbiome Project: Meeting Report for the 1st Hospital Microbiome Project Workshop on sampling design and building science measurements, Chicago, USA, June 7th-8th 2012

    PubMed Central

    Smith, Daniel; Alverdy, John; An, Gary; Coleman, Maureen; Garcia-Houchins, Sylvia; Green, Jessica; Keegan, Kevin; Kelley, Scott T.; Kirkup, Benjamin C.; Kociolek, Larry; Levin, Hal; Landon, Emily; Olsiewski, Paula; Knight, Rob; Siegel, Jeffrey; Weber, Stephen; Gilbert, Jack

    2013-01-01

    This report details the outcome of the 1st Hospital Microbiome Project workshop held on June 7th-8th, 2012 at the University of Chicago, USA. The workshop was arranged to determine the most appropriate sampling strategy and approach to building science measurement to characterize the development of a microbial community within a new hospital pavilion being built at the University of Chicago Medical Center. The workshop made several recommendations and led to the development of a full proposal to the Alfred P. Sloan Foundation as well as to the creation of the Hospital Microbiome Consortium. PMID:23961316

  9. The production and preclinical characterization of a chimeric anti-breast-cancer antibody, cBC2.

    PubMed

    Sutton, V R; Burgess, J; Pietersz, G A; Li, W J; McKenzie, I F; Trapani, J A

    1994-04-01

    A chimeric (mouse-human) BC2 antibody (cBC2) was produced which may be used in the diagnosis and treatment of breast cancer. The BC2 variable region genes were amplified by polymerase chain reaction (PCR), using oligonucleotide primers homologous to the framework sequences of mouse VH and V kappa genes. The PCR products were used to create cBC2 expression vectors containing the mouse BC2 VH and V kappa and human constant region (IgG1 and K) genes. Chimeric antibody was produced following transfection of these constructs into Sp2/0 myeloma cells. Binding assays in vitro demonstrated that cBC2 had the same specificity for human milk fat globule membrane (HMFGM) and MUC1+ cells as mBC2, and bound antigen with a similar affinity (cBC2, Ka 5.53 +/- 2.09 x 10(8); mBC2, Ka 1.44 +/- 0.98 x 10(9)). Functionally, only cBC2 (5-25 micrograms ml-1), was able to mediate antibody-dependent cellular cytotoxicity (ADCC) with human effector cells, with 25% maximal specific lysis of MUC1+ cells at an E/T ratio of 100:1. Human complement-mediated lysis was minimal (10-15% specific lysis) with both mBC2 and cBC2. Neither cBC2 nor mBC2 was able to inhibit tumour growth in vivo in the absence of covalently coupled anticancer drugs. However, biodistribution studies demonstrated that both antibodies preferentially targeted MUC1+ tumour cells, with 17% of the injected dose of cBC2, as compared to 27% of mBC2, localized to the MUC1+ tumour at 24 h (less than 6% detected in any other tissue). PMID:7584487

  10. Simulation of Arctic Black Carbon using Hemispheric CMAQ: Role of Russia's BC Emissions, Transport, and Deposition

    NASA Astrophysics Data System (ADS)

    Huang, K.; Fu, J. S.

    2015-12-01

    Black carbon plays a unique role in the Arctic climate system due to its multiple effects. It causes Arctic warming by directly absorbing sunlight from space and by darkening the surface albedo of snow and ice, which indirectly leads to further warming and melting, thus inducing an Arctic amplification effect. BC depositions over the Arctic are more sensitive to regions in close proximity. In this study, we reconstruct BC emissions for Russian Federation, which is the country that occupies the largest area in the Arctic Circle. Local Russia information such as activity data, emission factors and other emission source data are used. In 2010, total anthropogenic BC emission of Russia is estimated to be around 254 Gg. Gas flaring, a commonly ignored black carbon source, contributes a dominant 43.9% of Russia's total anthropogenic BC emissions. Other sectors, i.e., residential, transportation, industry, and power plants, contribute 22.0%, 17.8%, 11.5%, and 4.8%, respectively. BC simulations were conducted using the hemispheric version of CMAQ with polar projection. Emission inputs are from a global emissions database EDGAR (Emissions Database for Global Atmospheric Research)-HTAPv2 (Hemispheric Transport of Air Pollution) and EDGAR-HTAPv2 with its Russian part replaced by the newly developed Russian BC emissions, respectively. The simulations using the new Russian BC emission inventory could improve 46 - 61% of the Absorption Aerosol Optical Depth (AAOD) measured at the AERONET sites in Russia throughout the whole year as compared to that using the default HTAPv2 emissions. At the four air monitoring sites (Zeppelin, Barrow, Alert, and Tiksi) in the Arctic Circle, surface BC simulations are improved the most during the Arctic haze periods (October - March). Emission perturbation studies show that Russia's BC emissions contribute over 50% of the surface BC concentrations over the Arctic during the cold seasons. This study demonstrates the good capability of H-CMAQ in

  11. Synthesis of new Diamond-like B-C Phases under High Pressure and Temperatures

    SciTech Connect

    Ming, L. C.; Zinin, P. V.; Sharma, S. K.

    2014-04-22

    A cubic BC3 (c-BC3) phase was synthesized by direct transformation from graphitic phases at a pressure of 39 GPa and temperature of 2200 K in a laser-heated diamond anvil cell (DAC). A combination of x-ray diffraction (XRD), electron diffraction (ED), transmission electron microscopy (TEM) imaging, and electron energy loss spectroscopy (EELS) measurements lead us to conclude that the obtained phase is hetero-nano-diamond, c-BC3. The EELS measurements show that the atoms inside the cubic structure are bonded by sp3 bonds.

  12. Volume of Courses Students Carry among Central Data Warehouse (CDW) Institutions: Implications for Recalibration of the BC Transfer System

    ERIC Educational Resources Information Center

    Box, Dale

    2008-01-01

    The British Columbia (BC) Council on Admissions and Transfer (BCCAT) has undertaken, in the last couple of years, a review of the BC Transfer System. Preliminary findings indicate that the current structure of the BC Transfer Guide (BCTG), which designates institutions as either "sending" institutions or "receiving" institutions, based upon their…

  13. Study of the B+c → J/ΨD+s and B+c → J/ΨD*s+ decays with the ATLAS detector

    DOE PAGESBeta

    Aad, G.; Abbott, B.; Abdallah, J.; Abdinov, O.; Aben, R.; Abolins, M.; AbouZeid, O. S.; Abramowicz, H.; Abreu, H.; Abreu, R.; et al

    2016-01-05

    The decays B+c → J/ΨD+s and B+c → J/ΨD*s+ are studied with the ATLAS detector at the LHC using a dataset corresponding to integrated luminosities of 4.9 and 20.6 fb–1 of pp collisions collected at centre-of-mass energies √s = 7 TeV and 8 TeV, respectively. Furthermore, signal candidates are identified through J/ψ → μ+μ- and D(*)+s → Φπ+(γ/π0) decays.

  14. Some physics from 550 BC to AD 1948.

    PubMed

    Ganz, Jeremy C

    2014-01-01

    This chapter outlines terminology and its origins. It traces the development of physics ideas from Thales of Miletus, via Isaac Newton, to the nuclear physics investigations at the beginning of the twentieth century. It also outlines the evolving technology required to make the discoveries that would form the basis of radiosurgery. Up to the 1920s, all experiments on atomic structure and radioactivity had involved the use of vacuum tubes and naturally occurring radioactive substances. There was a need to make useable subatomic particles to obtain better understanding of the interior structure of atoms. Because of this, machines that could make atoms move at high speed were invented, known as particle accelerators. A new era had dawned. There is a brief mention of the effect of radiation on living tissue and of the units used to measure it. PMID:25376565

  15. Harmonization of description and classification of fetal observations: achievements and problems still unresolved: report of the 7th Workshop on the Terminology in Developmental Toxicology Berlin, 4-6 May 2011.

    PubMed

    Solecki, Roland; Barbellion, Stephane; Bergmann, Brigitte; Bürgin, Heinrich; Buschmann, Jochen; Clark, Ruth; Comotto, Laura; Fuchs, Antje; Faqi, Ali Said; Gerspach, Ralph; Grote, Konstanze; Hakansson, Helen; Heinrich, Verena; Heinrich-Hirsch, Barbara; Hofmann, Thomas; Hübel, Ulrich; Inazaki, Thelma Helena; Khalil, Samia; Knudsen, Thomas B; Kudicke, Sabine; Lingk, Wolfgang; Makris, Susan; Müller, Simone; Paumgartten, Francisco; Pfeil, Rudolf; Rama, Elkiane Macedo; Schneider, Steffen; Shiota, Kohei; Tamborini, Eva; Tegelenbosch, Mariska; Ulbrich, Beate; van Duijnhoven, E A J; Wise, David; Chahoud, Ibrahim

    2013-01-01

    This article summarizes the 7th Workshop on the Terminology in Developmental Toxicology held in Berlin, May 4-6, 2011. The series of Berlin Workshops has been mainly concerned with the harmonization of terminology and classification of fetal anomalies in developmental toxicity studies. The main topics of the 7th Workshop were knowledge on the fate of anomalies after birth, use of Version 2 terminology for maternal-fetal observations and non-routinely used species, reclassification of "grey zone" anomalies and categorization of fetal observations for human health risk assessment. The paucity of data on health consequences of the postnatal permanence of fetal anomalies is relevant and further studies are needed. The Version 2 terminology is an important step forward and the terms listed in this glossary are considered also to be appropriate for most observations in non-routinely used species. Continuation of the Berlin Workshops was recommended. Topics suggested for the next Workshop were grouping of fetal observations for reporting and statistical analysis. PMID:22781580

  16. Identifying 21st Century Capabilities

    ERIC Educational Resources Information Center

    Stevens, Robert

    2012-01-01

    What are the capabilities necessary to meet 21st century challenges? Much of the literature on 21st century skills focuses on skills necessary to meet those challenges associated with future work in a globalised world. The result is a limited characterisation of those capabilities necessary to address 21st century social, health and particularly…

  17. Laplace method for the evolution of the fragmentation function of Bc mesons

    NASA Astrophysics Data System (ADS)

    Boroun, G. R.; Zarrin, S.; Dadfar, S.

    2016-09-01

    In high-energy processes, the predominant mechanism for b bar c bound states is the production of a high-energy b bar or c quark, which fragments into the b bar c state. An approximate approach for the evolution of the fragmentation functions for the production of the S-wave states of Bc and Bc* is presented using Laplace transform technique in the leading order (LO) and next-to-leading order (NLO) analyses. The cross sections, as a function of the transverse momentum for the direct hadro-production b bar (c) →Bc and b bar (c) →Bc* based on the nonrelativistic quantum chromodynamics (QCD) factorization, are determined and compared with the Large Hadron Collider (LHC) and Tevatron data at the 1S-wave state.

  18. Microstructures of A 4(BC)4 star copolymers and the influence of architecture

    NASA Astrophysics Data System (ADS)

    Zhou, L.; Peng, J.; Cheng, M. F.; Fang, J. H.

    2016-07-01

    The self-consistent field theory is used to investigate the microstructures of A 4(BC)4 star copolymers. The phase diagram is mapped out to show different phase regions. Compared with A(BC)4 star copolymers, several microstructures are lost, and more lamellar structures are found due to the stronger topological constraint of the junction. The results may be helpful to understand the influence of molecular architectures on microstructures and provide an effective way to design controllable microstructures.

  19. The ϒ(1S)→Bcρ decay with perturbative QCD approach

    NASA Astrophysics Data System (ADS)

    Sun, Junfeng; Yang, Yueling; Li, Qingxia; Lu, Gongru; Huang, Jinshu; Chang, Qin

    2016-08-01

    With the potential prospects of the ϒ (1 S) data samples at the running LHC and upcoming SuperKEKB, the ϒ (1 S) →Bc ρ weak decay is studied with the pQCD approach. It is found that (1) the lion's share of branching ratio comes from the longitudinal polarization helicity amplitudes; (2) branching ratio for the ϒ (1 S) →Bc ρ decay can reach up to O (10-9), which might be hopefully measurable.

  20. Synthesis of models of the BC ring systems of MPC1001 and MPC1001F.

    PubMed

    Dong, Shuai; Indukuri, Kiran; Clive, Derrick L J; Gao, Jin-Ming

    2016-07-01

    Piperazinedione 13, representing the BC rings of the anti-prostate cancer fungal metabolite MPC1001, was prepared by a route in which a sulfur-stabilized carbanion derived from 22 cyclizes onto the terminal ester of the pendant chain attached to N(1). Another model, 14, was synthesized by cyclization of an α-ketoamide nitrogen onto an ester; 14 represents the BC rings of MPC1001F. PMID:27284641

  1. Mapping genes for liability to exencephaly in SELH/Bc mice

    SciTech Connect

    Gunn, T.M.; Juriloff, D.M.

    1994-09-01

    Exencephaly occurs in 6-20% of SELH/Bc strain mouse embryos. Liability to the cranial neural tube closure defect in SELH/Bc is multigenic, making it a good animal model for the study of the common human homolog, anencephaly. Our previous studies showed that the exencephaly-liability in SELH/Bc is caused by 2 or 3 loci. We have undertaken to map these genes. We crossed SELH/Bc to the normal strain, LM/Bc, and are using the F{sub 2}generation to map the segregating liability loci. 100 F{sub 2} males are being testcrossed to SELH/Bc to determine their genetic liability to exencephaly (based on frequency produced in their offspring, 100 scoreable embryos each). 83 males have been tested to date, producing exencephaly frequencies of between 0% and 16%. 26 have produced 0% exencephaly; 10 have produced at least 6%. These frequencies indicate that fewer than four exencephaly-liability loci are segregating. DNA from the 10 F{sub 2} males that produce the highest frequency of exencephaly and 10 that produce no exencephaly are being typed for microsatellite markers covering the 19 autosomes at 20 cM (or less) intervals. Of the 221 markers typed to date, 94 (43%) are detectably different between SELH/Bc and LM/Bc. Preliminary data based on five 0% males and five {open_quotes}high{close_quotes} males has excluded several chromosomal regions for the presence of an exencephaly-liability locus; e.g., most of chromosomes 2, 3, 4, 7, 12, 15, 17, and 19. The preliminary data suggest that there may be an exencephaly-liability locus on chromosome 13.

  2. Black carbon (BC) of urban topsoil of steel industrial city (Anshan), Northeastern China: Concentration, source identification and environmental implication.

    PubMed

    Zong, Yutong; Xiao, Qing; Lu, Shenggao

    2016-11-01

    Black carbon (BC) and total carbon (TC) concentrations in urban topsoils and vertical profiles from steel industrial city, Anshan, Northeastern China, were determined. A total of 115 topsoil samples and 4 soil profiles were collected, in which the BC concentrations were determined using chemical oxidation technique. The BC concentrations in urban topsoils are in the range of 1.86 to 246.46gkg(-1) with an average of 33.86gkg(-1). Both BC and TC concentrations decrease sharply with soil depth, whereas BC/TC ratio shows a little variation with depth. The spatial distribution of BC in urban topsoils reveals that the BC concentration is much higher in the northern part of the city, which is consistent with the steel production. The distribution factors (DF) of BC are the highest in 1000-500 and 500-250μm size fractions, while the lowest in 50-2μm fraction. The mass loading of BC in 250-50 and 50-2μm size fractions accounts for 76.2% of bulk soil, indicating these two size fractions responsible for BC accumulation in soils. Enrichment factor (EF) of BC in urban topsoils ranges from 0.92 to 122.01 with an average of 16.76, indicating that the urban topsoils studied are moderately or severely accumulated by the BC. Strong correlation is found between BC and pollution load index (PLI) of heavy metals, indicating the possibility of similar sources of BC and heavy metals in soils. The BC/TC ratio in soils ranges from 0.45 to 0.97, with an average of 0.75. The BC/TC ratio shows the mixed sources of BC derived from fossil fuel combustion and vehicle emissions. The BC concentration and BC/TC ratio may reflect the degree of industrial activities and pollution sources in urban soils. The study demonstrated that BC is an effective indicator of degree and "hotspots" of heavy metals pollution in urban soils. PMID:27450257

  3. Identification of Ubiquinol Binding Motifs at the Qo-Site of the Cytochrome bc1 Complex

    PubMed Central

    2014-01-01

    Enzymes of the bc1 complex family power the biosphere through their central role in respiration and photosynthesis. These enzymes couple the oxidation of quinol molecules by cytochrome c to the transfer of protons across the membrane, to generate a proton-motive force that drives ATP synthesis. Key for the function of the bc1 complex is the initial redox process that involves a bifurcated electron transfer in which the two electrons from a quinol substrate are passed to different electron acceptors in the bc1 complex. The electron transfer is coupled to proton transfer. The overall mechanism of quinol oxidation by the bc1 complex is well enough characterized to allow exploration at the atomistic level, but details are still highly controversial. The controversy stems from the uncertain binding motifs of quinol at the so-called Qo active site of the bc1 complex. Here we employ a combination of classical all atom molecular dynamics and quantum chemical calculations to reveal the binding modes of quinol at the Qo-site of the bc1 complex from Rhodobacter capsulatus. The calculations suggest a novel configuration of amino acid residues responsible for quinol binding and support a mechanism for proton-coupled electron transfer from quinol to iron–sulfur cluster through a bridging hydrogen bond from histidine that stabilizes the reaction complex. PMID:25372183

  4. Observation of an excited Bc(±) meson state with the ATLAS detector.

    PubMed

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Cristinziani, M; Croft, V; Crosetti, G; Cuciuc, C-M; Cuhadar Donszelmann, T; Cummings, J; Curatolo, M; Cuthbert, C; Czirr, H; Czodrowski, P; Czyczula, Z; D'Auria, S; D'Onofrio, M; Da Cunha Sargedas De Sousa, M J; Da Via, C; Dabrowski, W; Dafinca, A; Dai, T; Dale, O; Dallaire, F; Dallapiccola, C; Dam, M; Daniells, A C; Dano Hoffmann, M; Dao, V; Darbo, G; Darmora, S; Dassoulas, J A; Dattagupta, A; Davey, W; David, C; Davidek, T; Davies, E; Davies, M; Davignon, O; Davison, A R; Davison, P; Davygora, Y; Dawe, E; Dawson, I; Daya-Ishmukhametova, R K; De, K; de Asmundis, R; De Castro, S; De Cecco, S; De Groot, N; de Jong, P; De la Torre, H; De Lorenzi, F; De Nooij, L; De Pedis, D; De Salvo, A; De Sanctis, U; De Santo, A; De Vivie De Regie, J B; Dearnaley, W J; Debbe, R; Debenedetti, C; Dechenaux, B; Dedovich, D V; Deigaard, I; Del Peso, J; Del Prete, T; Deliot, F; Delitzsch, C M; Deliyergiyev, M; Dell'Acqua, A; Dell'Asta, L; Dell'Orso, M; Della Pietra, M; della Volpe, D; Delmastro, M; Delsart, P A; Deluca, C; Demers, S; Demichev, M; Demilly, A; Denisov, S P; Derendarz, D; Derkaoui, J E; Derue, F; Dervan, P; Desch, K; Deterre, C; Deviveiros, P O; Dewhurst, A; Dhaliwal, S; Di Ciaccio, A; Di Ciaccio, L; Di Domenico, A; Di Donato, C; Di Girolamo, A; Di Girolamo, B; Di Mattia, A; Di Micco, B; Di Nardo, R; Di Simone, A; Di Sipio, R; Di Valentino, D; Dias, F A; Diaz, M A; Diehl, E B; Dietrich, J; Dietzsch, T A; Diglio, S; Dimitrievska, A; Dingfelder, J; Dionisi, C; Dita, P; Dita, S; Dittus, F; Djama, F; Djobava, T; do Vale, M A B; Do Valle Wemans, A; Doan, T K O; Dobos, D; Doglioni, C; Doherty, T; Dohmae, T; Dolejsi, J; Dolezal, Z; Dolgoshein, B A; Donadelli, M; Donati, S; Dondero, P; Donini, J; Dopke, J; Doria, A; Dova, M T; Doyle, A T; Dris, M; Dubbert, J; Dube, S; Dubreuil, E; Duchovni, E; Duckeck, G; Ducu, O A; Duda, D; Dudarev, A; Dudziak, F; Duflot, L; Duguid, L; Dührssen, M; Dunford, M; Duran Yildiz, H; Düren, M; Durglishvili, A; Dwuznik, M; Dyndal, M; Ebke, J; Edson, W; Edwards, N C; 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Radloff, P; Rados, P; Ragusa, F; Rahal, G; Rajagopalan, S; Rammensee, M; Randle-Conde, A S; Rangel-Smith, C; Rao, K; Rauscher, F; Rave, T C; Ravenscroft, T; Raymond, M; Read, A L; Readioff, N P; Rebuzzi, D M; Redelbach, A; Redlinger, G; Reece, R; Reeves, K; Rehnisch, L; Reisin, H; Relich, M; Rembser, C; Ren, H; Ren, Z L; Renaud, A; Rescigno, M; Resconi, S; Rezanova, O L; Reznicek, P; Rezvani, R; Richter, R; Ridel, M; Rieck, P; Rieger, J; Rijssenbeek, M; Rimoldi, A; Rinaldi, L; Ritsch, E; Riu, I; Rizatdinova, F; Rizvi, E; Robertson, S H; Robichaud-Veronneau, A; Robinson, D; Robinson, J E M; Robson, A; Roda, C; Rodrigues, L; Roe, S; Røhne, O; Rolli, S; Romaniouk, A; Romano, M; Romero Adam, E; Rompotis, N; Roos, L; Ros, E; Rosati, S; Rosbach, K; Rose, M; Rosendahl, P L; Rosenthal, O; Rossetti, V; Rossi, E; Rossi, L P; Rosten, R; Rotaru, M; Roth, I; Rothberg, J; Rousseau, D; Royon, C R; Rozanov, A; Rozen, Y; Ruan, X; Rubbo, F; Rubinskiy, I; Rud, V I; Rudolph, C; Rudolph, M S; Rühr, F; Ruiz-Martinez, A; Rurikova, Z; Rusakovich, N A; Ruschke, A; Rutherfoord, J P; Ruthmann, N; Ryabov, Y F; Rybar, M; Rybkin, G; Ryder, N C; Saavedra, A F; Sacerdoti, S; Saddique, A; Sadeh, I; Sadrozinski, H F-W; Sadykov, R; Safai Tehrani, F; Sakamoto, H; Sakurai, Y; Salamanna, G; Salamon, A; Saleem, M; Salek, D; Sales De Bruin, P H; Salihagic, D; Salnikov, A; Salt, J; Salvachua Ferrando, B M; Salvatore, D; Salvatore, F; Salvucci, A; Salzburger, A; Sampsonidis, D; Sanchez, A; Sánchez, J; Sanchez Martinez, V; Sandaker, H; Sandbach, R L; Sander, H G; Sanders, M P; Sandhoff, M; Sandoval, T; Sandoval, C; Sandstroem, R; Sankey, D P C; Sansoni, A; Santoni, C; Santonico, R; Santos, H; Santoyo Castillo, I; Sapp, K; Sapronov, A; Saraiva, J G; Sarrazin, B; Sartisohn, G; Sasaki, O; Sasaki, Y; Sauvage, G; Sauvan, E; Savard, P; Savu, D O; Sawyer, C; Sawyer, L; Saxon, D H; Saxon, J; Sbarra, C; Sbrizzi, A; Scanlon, T; Scannicchio, D A; Scarcella, M; Scarfone, V; Schaarschmidt, J; Schacht, P; Schaefer, D; Schaefer, R; Schaepe, S; 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Yu, J M; Yu, J; Yuan, L; Yurkewicz, A; Yusuff, I; Zabinski, B; Zaidan, R; Zaitsev, A M; Zaman, A; Zambito, S; Zanello, L; Zanzi, D; Zeitnitz, C; Zeman, M; Zemla, A; Zengel, K; Zenin, O; Ženiš, T; Zerwas, D; Zevi della Porta, G; Zhang, D; Zhang, F; Zhang, H; Zhang, J; Zhang, L; Zhang, X; Zhang, Z; Zhao, Z; Zhemchugov, A; Zhong, J; Zhou, B; Zhou, L; Zhou, N; Zhu, C G; Zhu, H; Zhu, J; Zhu, Y; Zhuang, X; Zhukov, K; Zibell, A; Zieminska, D; Zimine, N I; Zimmermann, C; Zimmermann, R; Zimmermann, S; Zimmermann, S; Zinonos, Z; Ziolkowski, M; Zobernig, G; Zoccoli, A; zur Nedden, M; Zurzolo, G; Zutshi, V; Zwalinski, L

    2014-11-21

    A search for excited states of the Bc(±) meson is performed using 4.9  fb(-1) of 7 TeV and 19.2  fb(-1) of 8 TeV pp collision data collected by the ATLAS experiment at the LHC. A new state is observed through its hadronic transition to the ground state, with the latter detected in the decay Bc(±)→J/ψπ(±). The state appears in the m(Bc(±)π(+)π(-))-m(Bc(±))-2m(π(±)) mass difference distribution with a significance of 5.2 standard deviations. The mass of the observed state is 6842±4±5  MeV, where the first error is statistical and the second is systematic. The mass and decay of this state are consistent with expectations for the second S-wave state of the Bc(±) meson, Bc(±)(2S). PMID:25479491

  5. BcIEB1, a Botrytis cinerea secreted protein, elicits a defense response in plants.

    PubMed

    Frías, Marcos; González, Mario; González, Celedonio; Brito, Nélida

    2016-09-01

    BcIEB1 is a very abundant protein in the secretome of Botrytis cinerea but it has no known function and no similarity to any characterized protein family. Previous results suggested that this protein is an elicitor of the plant defense system. In this work we have generated loss-of-function B. cinerea mutants lacking BcIEB1 and we have expressed the protein in yeast to assay its activity on plants. Analysis of the Δbcieb1 mutants did not result in any observable phenotype, including no difference in the virulence on a variety of hosts. However, when BcIEB1 was applied to plant tissues it produced necrosis as well as a whole range of symptoms: inhibition of seedling growth in Arabidopsis and tobacco, ion leakage from tobacco leaf disks, a ROS burst, cell death and autofluorescence in onion epidermis, as well as the expression of defense genes in tobacco. Moreover, tobacco plants treated with BcIEB1 showed an increased systemic resistance to B. cinerea. A small 35-amino acids peptide derived from a conserved region of BcIEB1 is almost as active on plants as the whole protein. These results clearly indicate that BcIEB1 elicits plant defenses, probably as a consequence of its recognition as a pathogen associated molecular pattern. PMID:27457989

  6. Biogenesis of the cytochrome bc(1) complex and role of assembly factors.

    PubMed

    Smith, Pamela M; Fox, Jennifer L; Winge, Dennis R

    2012-02-01

    The cytochrome bc(1) complex is an essential component of the electron transport chain in most prokaryotes and in eukaryotic mitochondria. The catalytic subunits of the complex that are responsible for its redox functions are largely conserved across kingdoms. In eukarya, the bc(1) complex contains supernumerary subunits in addition to the catalytic core, and the biogenesis of the functional bc(1) complex occurs as a modular assembly pathway. Individual steps of this biogenesis have been recently investigated and are discussed in this review with an emphasis on the assembly of the bc(1) complex in the model eukaryote Saccharomyces cerevisiae. Additionally, a number of assembly factors have been recently identified. Their roles in bc(1) complex biogenesis are described, with special emphasis on the maturation and topogenesis of the yeast Rieske iron-sulfur protein and its role in completing the assembly of functional bc(1) complex. This article is part of a Special Issue entitled: Biogenesis/Assembly of Respiratory Enzyme Complexes. PMID:22138626

  7. Reprint of: Biogenesis of the cytochrome bc(1) complex and role of assembly factors.

    PubMed

    Smith, Pamela M; Fox, Jennifer L; Winge, Dennis R

    2012-06-01

    The cytochrome bc(1) complex is an essential component of the electron transport chain in most prokaryotes and in eukaryotic mitochondria. The catalytic subunits of the complex that are responsible for its redox functions are largely conserved across kingdoms. In eukarya, the bc(1) complex contains supernumerary subunits in addition to the catalytic core, and the biogenesis of the functional bc(1) complex occurs as a modular assembly pathway. Individual steps of this biogenesis have been recently investigated and are discussed in this review with an emphasis on the assembly of the bc(1) complex in the model eukaryote Saccharomyces cerevisiae. Additionally, a number of assembly factors have been recently identified. Their roles in bc(1) complex biogenesis are described, with special emphasis on the maturation and topogenesis of the yeast Rieske iron-sulfur protein and its role in completing the assembly of functional bc(1) complex. This article is part of a Special Issue entitled: Biogenesis/Assembly of Respiratory Enzyme Complexes. PMID:22564912

  8. Structural analysis of substrate binding by the TatBC component of the twin-arginine protein transport system.

    PubMed

    Tarry, Michael J; Schäfer, Eva; Chen, Shuyun; Buchanan, Grant; Greene, Nicholas P; Lea, Susan M; Palmer, Tracy; Saibil, Helen R; Berks, Ben C

    2009-08-11

    The Tat system transports folded proteins across the bacterial cytoplasmic membrane and the thylakoid membrane of plant chloroplasts. In Escherichia coli substrate proteins initially bind to the integral membrane TatBC complex which then recruits the protein TatA to effect translocation. Overproduction of TatBC and the substrate protein SufI in the absence of TatA led to the accumulation of TatBC-SufI complexes that could be purified using an affinity tag on the substrate. Three-dimensional structures of the TatBC-SufI complexes and unliganded TatBC were obtained by single-particle electron microscopy and random conical tilt reconstruction. Comparison of the structures shows that substrate molecules bind on the periphery of the TatBC complex and that substrate binding causes a significant reduction in diameter of the TatBC part of the complex. Although the TatBC complex contains multiple copies of the signal peptide-binding TatC protomer, purified TatBC-SufI complexes contain only 1 or 2 SufI molecules. Where 2 substrates are present in the TatBC-SufI complex, they are bound at adjacent sites. These observations imply that only certain TatC protomers within the complex interact with substrate or that there is a negative cooperativity of substrate binding. Similar TatBC-substrate complexes can be generated by an alternative in vitro reconstitution method and using a different substrate protein. PMID:19666509

  9. Astronomy in Ireland from earliest times to the eighteenth century

    NASA Astrophysics Data System (ADS)

    McKenna-Lawlor, Susan M. P.

    Evidence that the builders of Irish passage graves and stone circles may have possessed some knowledge of basic celestial cycles is discussed. The introduction of Celtic culture to Ireland circa 600 B.C. is next described and an account of the astronomical learning of the Celts provided based on classical documentation and Irish vernacular sources. Following on the coming of Christianity to Ireland in the fifth century, the necessity to construct Easter tables led Irish monks to such related activities as establishing collections of computi, compiling Annals and undertaking studies of available astronomical material. In particular, through exposure to Helenistic writings, they understood celestial motions in terms of the Ptolemaic model and were recognised authorities in Europe in the eighth and ninth centuries on astronomical matters. The influence of the Viking and Norman invasions in disrupting the intellectual life of the country is then outlined and the circumstances relating to the creation of conditions leading to the brilliant flowering of Irish astronomy in the eighteenth century are elucidated.

  10. Plague: the dreadful visitation occupying the human mind for centuries.

    PubMed

    Khan, Iqbal Akhtar

    2004-05-01

    Plague is one of mankind's greatest scourges, which has swept away millions of people over the centuries. The first available record of the occurrence of this calamity, in humans, is from the Bible, in 1000 bc, in the city of Ashdod. The first definitely identified pandemic originated in Egypt in ad 542 (the Justinian Plague) and is estimated to have caused 100 million deaths. The second one, lasting for three centuries and claiming over 25 million lives appeared in 1334 in China spreading to many spots on the globe. The third pandemic occurred in Europe from the fifteenth to eighteenth century. The current pandemic began around 1860, in the Chinese province Yunnan; it reached Hong Kong in 1894 killing 100 000 individuals. Within 20 years the disease spread from southern Chinese ports throughout the world resulting in more than 10 million deaths. Since the discovery of the causative agent in 1894, there have been remarkable advancements in immunoprophylaxis and chemoprophylaxis. However, the disease is still active in Africa, in Asia and in Americas and has been classified as a currently re-emerging disease. A 'Plague-free World' will probably remain a dream for an indefinite period. PMID:15109549

  11. BcMF26a and BcMF26b Are Duplicated Polygalacturonase Genes with Divergent Expression Patterns and Functions in Pollen Development and Pollen Tube Formation in Brassica campestris

    PubMed Central

    Lyu, Meiling; Yu, Youjian; Jiang, Jingjing; Song, Limin; Liang, Ying; Ma, Zhiming; Xiong, Xingpeng; Cao, Jiashu

    2015-01-01

    Polygalacturonase (PG) is one of the cell wall hydrolytic enzymes involving in pectin degradation. A comparison of two highly conserved duplicated PG genes, namely, Brassica campestris Male Fertility 26a (BcMF26a) and BcMF26b, revealed the different features of their expression patterns and functions. We found that these two genes were orthologous genes of At4g33440, and they originated from a chromosomal segmental duplication. Although structurally similar, their regulatory and intron sequences largely diverged. QRT-PCR analysis showed that the expression level of BcMF26b was higher than that of BcMF26a in almost all the tested organs and tissues in Brassica campestris. Promoter activity analysis showed that, at reproductive development stages, BcMF26b promoter was active in tapetum, pollen grains, and pistils, whereas BcMF26a promoter was only active in pistils. In the subcellular localization experiment, BcMF26a and BcMF26b proteins could be localized to the cell wall. When the two genes were co-inhibited, pollen intine was formed abnormally and pollen tubes could not grow or stretch. Moreover, the knockout mutants of At4g33440 delayed the growth of pollen tubes. Therefore, BcMF26a/b can participate in the construction of pollen wall by modulating intine information and BcMF26b may play a major role in co-inhibiting transformed plants. PMID:26153985

  12. BcMF26a and BcMF26b Are Duplicated Polygalacturonase Genes with Divergent Expression Patterns and Functions in Pollen Development and Pollen Tube Formation in Brassica campestris.

    PubMed

    Lyu, Meiling; Yu, Youjian; Jiang, Jingjing; Song, Limin; Liang, Ying; Ma, Zhiming; Xiong, Xingpeng; Cao, Jiashu

    2015-01-01

    Polygalacturonase (PG) is one of the cell wall hydrolytic enzymes involving in pectin degradation. A comparison of two highly conserved duplicated PG genes, namely, Brassica campestris Male Fertility 26a (BcMF26a) and BcMF26b, revealed the different features of their expression patterns and functions. We found that these two genes were orthologous genes of At4g33440, and they originated from a chromosomal segmental duplication. Although structurally similar, their regulatory and intron sequences largely diverged. QRT-PCR analysis showed that the expression level of BcMF26b was higher than that of BcMF26a in almost all the tested organs and tissues in Brassica campestris. Promoter activity analysis showed that, at reproductive development stages, BcMF26b promoter was active in tapetum, pollen grains, and pistils, whereas BcMF26a promoter was only active in pistils. In the subcellular localization experiment, BcMF26a and BcMF26b proteins could be localized to the cell wall. When the two genes were co-inhibited, pollen intine was formed abnormally and pollen tubes could not grow or stretch. Moreover, the knockout mutants of At4g33440 delayed the growth of pollen tubes. Therefore, BcMF26a/b can participate in the construction of pollen wall by modulating intine information and BcMF26b may play a major role in co-inhibiting transformed plants. PMID:26153985

  13. Second century megadrought in the Rio Grande headwaters, Colorado: How unusual was medieval drought?

    NASA Astrophysics Data System (ADS)

    Routson, Cody C.; Woodhouse, Connie A.; Overpeck, Jonathan T.

    2011-11-01

    A new tree-ring record from living and remnant bristlecone pine (Pinus aristata) wood from the headwaters region of the Rio Grande River, Colorado is used in conjunction with other regional records to evaluate periods of unusually severe drought over the past two millennia (B.C. 268 to A.D. 2009). Our new record contains a multi-century period of unusual dryness between 1 and 400 A.D., including an extreme drought during the 2nd century. Characterized by almost five decades of drought (below average ring width), we hypothesize this megadrought is equally, if not more severe than medieval period megadroughts in this region. Published paleoclimate time series help define the spatial extent, severity, and potential causes of the 2nd century megadrought. Furthermore, this early period of unusual dryness has intriguing similarities to later medieval period aridity. Our findings suggest we should anticipate similar severe drought conditions in an even warmer and drier future.

  14. Synthetic approaches to borocarbonitrides, BC{sub x}N (x=1-2)

    SciTech Connect

    Kumar, Nitesh; Raidongia, Kalyan; Mishra, Abhishek K.; Waghmare, Umesh V.; Sundaresan, A.; Rao, C.N.R.

    2011-11-15

    In order to synthesize borocarbonitrides of the general formula BC{sub x}N where x varies between 1 and 2, we have carried out high-temperature gas phase reaction of BBr{sub 3} with a mixture of ethylene and ammonia. The composition of the product was close to BC{sub 1.6}N as shown by x-ray photon spectroscopy (XPS) and electron energy loss spectroscopy (EELS). The products were further characterized by infra-red, Raman and other spectroscopic techniques. The borocarbonitrides obtained from the gas phase reaction have low surface areas, in contrast to those of similar compositions prepared by the urea method. First principles calculations show that the most stable structures of the compositions BCN and BC{sub 2}N contain BN-rich and carbon-rich domains where BN{sub 3} and NB{sub 3} units are present. - Graphical abstract: Vapor phase synthesis of BC{sub x}N (x=1-2) by the reaction of BBr{sub 3}, ethylene and ammonia leads to the formation of pan-like structure. Highlights: > We have carried out vapor phase reaction of BBr{sub 3}, ethylene and ammonia to synthesize BC{sub x}N (x=1-2). > HRTEM and AFM show the formation of pan-like structures with the central region formed of single layer of BC{sub x}N. > Borocarbonitrides formed by vapor phase synthesis show limited adsorption properties as compared to the urea route. > First principles calculations show that the most stable structure of the compositions BCN and BC{sub 2}N contain BN-rich and carbon-rich domains where BN{sub 3} and NB{sub 3} units are present.

  15. The management century.

    PubMed

    Kiechel, Walter

    2012-11-01

    In 1886, addressing the nascent American Society of Mechanical Engineers, Henry R. Towne proposed that "the management of works" be considered a modern art--thereby heralding the Management Century, when management as we know it came into being and shaped the world in which we work. Kiechel, a past editorial director of Harvard Business Publishing, elucidates the three eras that punctuate this period: the years leading up to World War II, during which scientific exactitude gave wings to a new managerial elite; the early postwar decades, managerialism's apogee of self-confidence and a time when wartime principles of strategy were adapted, sometimes ruthlessly, to the running of companies; and the 1980s to the present, years that saw fast-moving changes, disequilibrium, and a servitude to market forces but also ushered in globalism, unprecedented innovation, and heightened expectations about how workers are to be treated. Along the way he examines the contributions of thinkers such as Frederick Taylor, Elton Mayo, Peter Drucker, and Michael Porter. What lies ahead? Perhaps the biggest challenge facing the 21st-century company, Kiechel posits, is to truly free the spark of human imagination from the organization's tidal pull toward the status quo. There's almost always a better way, he concludes--and management will continue to seek it. PMID:23155998

  16. The Beginning of Metallurgy in the Southern Levant: A Late 6th Millennium CalBC Copper Awl from Tel Tsaf, Israel

    PubMed Central

    Garfinkel, Yosef; Klimscha, Florian; Shalev, Sariel; Rosenberg, Danny

    2014-01-01

    The beginning of metallurgy in the ancient Near East attracts much attention. The southern Levant, with the rich assemblage of copper artifacts from the Nahal Mishmar cave and the unique gold rings of the Nahal Qanah cave, is regarded as a main center of early metallurgy during the second half of the 5th millennium CalBC. However, a recently discovered copper awl from a Middle Chalcolithic burial at Tel Tsaf, Jordan Valley, Israel, suggests that cast metal technology was introduced to the region as early as the late 6th millennium CalBC. This paper examines the chemical composition of this item and reviews its context. The results indicate that it was exported from a distant source, probably in the Caucasus, and that the location where it was found is indicative of the social status of the buried individual. This rare finding indicates that metallurgy was first defused to the southern Levant through exchange networks and only centuries later involved local production. This copper awl, the earliest metal artifact found in the southern Levant, indicates that the elaborate Late Chalcolithic metallurgy developed from a more ancient tradition. PMID:24671185

  17. The beginning of metallurgy in the southern Levant: a late 6th millennium CalBC copper awl from Tel Tsaf, Israel.

    PubMed

    Garfinkel, Yosef; Klimscha, Florian; Shalev, Sariel; Rosenberg, Danny

    2014-01-01

    The beginning of metallurgy in the ancient Near East attracts much attention. The southern Levant, with the rich assemblage of copper artifacts from the Nahal Mishmar cave and the unique gold rings of the Nahal Qanah cave, is regarded as a main center of early metallurgy during the second half of the 5th millennium CalBC. However, a recently discovered copper awl from a Middle Chalcolithic burial at Tel Tsaf, Jordan Valley, Israel, suggests that cast metal technology was introduced to the region as early as the late 6th millennium CalBC. This paper examines the chemical composition of this item and reviews its context. The results indicate that it was exported from a distant source, probably in the Caucasus, and that the location where it was found is indicative of the social status of the buried individual. This rare finding indicates that metallurgy was first diffused [corrected] to the southern Levant through exchange networks and only centuries later involved local productionThis copper awl, the earliest metal artifact found in the southern Levant, indicates that the elaborate Late Chalcolithic metallurgy developed from a more ancient tradition. PMID:24671185

  18. BcMtg2 is required for multiple stress tolerance, vegetative development and virulence in Botrytis cinerea.

    PubMed

    Shao, Wenyong; Zhang, Yu; Wang, Jin; Lv, Chiyuan; Chen, Changjun

    2016-01-01

    In Saccharomyces cerevisiae, the Mtg2 gene encodes the Obg protein, which has an important function in assembling ribosomal subunits. However, little is known about the role of the Obg GTPase in filamentous fungi. In this study, we identified an Mtg2 ortholog, BcMtg2, in B. cinerea. The BcMtg2 deletion mutant showed a defect in spore production, conidial germination and sclerotial formation. Additionally, the mutant increased sensitivity to various environmental stresses. The BcMtg2 mutant exhibited dramatically decreased virulence on host plant tissues. BcMtg2 mutant showed increased sensitivity to osmotic and oxidative stresses, and to Congo red (cell wall stress agent). In the yeast complement assay, growth defects of yeast BY4741ΔMTG2 mutant were partly restored by genetic complementation of BcMtg2 under these environmental stresses. Additionally, compared with the parental strain and complement strain, the BcMtg2 deletion mutant displayed a minor glycerol response to osmosis stress. These defective phenotypes were recovered in the complement strain ΔBcMtg2C, which was created by adding the wild-type BcMtg2 gene to the ΔBcMtg2 mutant. The results of this study indicate that BcMtg2 has a necessary role in asexual development, environmental stress response and pathogenicity in B. cinerea. PMID:27346661

  19. BcMtg2 is required for multiple stress tolerance, vegetative development and virulence in Botrytis cinerea

    PubMed Central

    Shao, Wenyong; Zhang, Yu; Wang, Jin; Lv, Chiyuan; Chen, Changjun

    2016-01-01

    In Saccharomyces cerevisiae, the Mtg2 gene encodes the Obg protein, which has an important function in assembling ribosomal subunits. However, little is known about the role of the Obg GTPase in filamentous fungi. In this study, we identified an Mtg2 ortholog, BcMtg2, in B. cinerea. The BcMtg2 deletion mutant showed a defect in spore production, conidial germination and sclerotial formation. Additionally, the mutant increased sensitivity to various environmental stresses. The BcMtg2 mutant exhibited dramatically decreased virulence on host plant tissues. BcMtg2 mutant showed increased sensitivity to osmotic and oxidative stresses, and to Congo red (cell wall stress agent). In the yeast complement assay, growth defects of yeast BY4741ΔMTG2 mutant were partly restored by genetic complementation of BcMtg2 under these environmental stresses. Additionally, compared with the parental strain and complement strain, the BcMtg2 deletion mutant displayed a minor glycerol response to osmosis stress. These defective phenotypes were recovered in the complement strain ΔBcMtg2C, which was created by adding the wild-type BcMtg2 gene to the ΔBcMtg2 mutant. The results of this study indicate that BcMtg2 has a necessary role in asexual development, environmental stress response and pathogenicity in B. cinerea. PMID:27346661

  20. Classification of Babesia canis strains in Europe based on polymorphism of the Bc28.1-gene from the Babesia canis Bc28 multigene family.

    PubMed

    Carcy, B; Randazzo, S; Depoix, D; Adaszek, L; Cardoso, L; Baneth, G; Gorenflot, A; Schetters, T P

    2015-07-30

    The vast majority of clinical babesiosis cases in dogs in Europe is caused by Babesia canis. Although dogs can be vaccinated, the level of protection is highly variable, which might be due to genetic diversity of B. canis strains. One of the major merozoite surface antigens of B. canis is a protein with a Mr of 28 kDa that belongs to the Bc28 multigene family, that comprises at least two genes, Bc28.1 and a homologous Bc28.2 gene. The two genes are relatively conserved but they are very distinct in their 3' ends, enabling the design of specific primers. Sequencing of the Bc28.1 genes from 4 genetically distinct B. canis laboratory strains (A8, B, 34.01 and G) revealed 20 mutations at conserved positions of which three allowed the classification of B. canis strains into three main groups (A, B and 34.01/G) by RFLP. This assay was subsequently used to analyze blood samples of 394 dogs suspected of clinical babesiosis from nine countries in Europe. All blood samples were first analyzed with a previously described assay that allowed detection of the different Babesia species that infect dogs. Sixty one percent of the samples contained detectable levels of Babesia DNA. Of these, 98.3% were positive for B. canis, the remaining cases were positive for B. vogeli. Analysis of the Bc28.1 gene, performed on 178 of the B. canis samples, revealed an overall dominance of genotype B (62.4%), followed by genotypes A (37.1%) and 34 (11.8%). Interestingly, a great variation in the geographical distribution and prevalence of the three B. canis genotypes was observed; in the North-East genotype A predominated (72.1% A against 27.9% B), in contrast to the South-West where genotype B predominated (10.3% A against 89.7% B). In the central part of Europe intermediate levels were found (26.0-42.9% A against 74.0-57.1% B, from West to East). Genotype 34 was only identified in France (26.9% among 78 samples) and mostly as co-infection with genotypes A or B (61.9%). A comparative analysis of

  1. Polycyclic aromatic hydrocarbon (PAH) sorption process to the "black carbon" (BC) component in river sediments

    NASA Astrophysics Data System (ADS)

    Zhang, Jing; Séquaris, Jean-Marie; Narres, Hans-Dieter; Vereecken, Harry; Klumpp, Erwin

    2010-05-01

    The importance of BC for the long term sequestration of organic carbon is actually discussed for mitigating climate change. In this context, the role of BC as a filter or source of nutrients or toxic chemicals is questioned. The fate of polycyclic aromatic hydrocarbons (PAHs) is especially concerned. In this study, we have investigated the binding of PAH compounds, pyrene and phenanthrene, to Yangtze River sediments. For this purpose, the PAHs sorption to pristine and preheated sediments at 375°C was studied, which allow discriminating the contributions of amorphous organic carbon (AOC) and black carbon (BC) fractions to the PAH sorption extent. An analytical procedure for the determination of PAHs in the solution phase of the batch experiments has been developed with fluorescence spectroscopy. The PAHs sorption isotherms to pristine sediments were fitted by Freundlich and composite models as linear Langmuir model (LLM) and linear Polanyi-Dubinin-Manes model (LPDMM). The sequential application of composite models LLM and LPDMM to the sorption isotherms allows assessing the partition of PAHs into AOC and its nonlinear adsorption in the porous structure of BC. The modelling results indicate that the PAHs sorption to minor BC component of sediments (< 0.2 % TOC) is more effective than that to the major AOC component (< 1.3 % TOC). A similar sorption capacity of BC in pristine and preheated sediments is also calculated at high PAHs concentrations, which indicates that the AOC fraction does not block the micropore filling of BC. The microporous structure and the hydrophobic nature of BC component in sediments are thus factors, which create favourable energetic sites for the sorption of PAHs in the river sediments. It can also be shown that a BC molecular sieving plays an important role in the competitive PAHs sorption in a multi-solute system. J. Zhang, Ph.D. Dissertation, RWTH Aachen, Germany, 2010 J. Zhang et al., Effects of organic carbon and clay fractions on the

  2. Three-Dimensional BC/PEDOT Composite Nanofibers with High Performance for Electrode-Cell Interface.

    PubMed

    Chen, Chuntao; Zhang, Ting; Zhang, Qi; Feng, Zhangqi; Zhu, Chunlin; Yu, Yalin; Li, Kangming; Zhao, Mengyao; Yang, Jiazhi; Liu, Jian; Sun, Dongping

    2015-12-30

    There is an increasing need to synthesize biocompatible nanofibers with excellent mechanical and electrical performance for electrochemical and biomedical applications. Here we report a facile approach to prepare electroactive and flexible 3D nanostructured biomaterials with high performance based on bacterial cellulose (BC) nanofibers. Our approach can coat BC nanofibers with poly(3,4-ethylenedioxythiophene) (PEDOT) by in situ interfacial polymerization in a controllable manner. The PEDOT coating thickness is adjustable by the monomer concentration or reaction time during polymerization, producing nanofibers with a total diameter ranging from 30 to 200 nm. This fabrication process also provides a convenient method to tune different parameters such as the average pore size and electrical conductivity on the demands of actual applications. Our experiments have demonstrated that the 3D BC/PEDOT nanofibers exhibit high specific surface area, excellent mechanical properties, electroactive stability, and low cell cytotoxicity. With electrical stimulation, calcium imaging of PC12 neural cells on BC/PEDOT nanofibers has revealed a significant increase in the percentage of cells with higher action potentials, suggesting an enhanced capacitance effect of charge injection. As an attractive solution to the challenge of designing better electrode-cell interfaces, 3D BC/PEDOT nanofibers promise many important applications such as biosensing devices, smart drug delivery systems, and implantable electrodes for tissue engineering. PMID:26550840

  3. Crystal Structure of the GerBC Component of a Bacillus Subtilis Spore Germinant Receptor

    SciTech Connect

    Li, Y.; Setlow, B; Setlow, P; Hao, B

    2010-01-01

    The nutrient germinant receptors (nGRs) of spores of Bacillus species are clusters of three proteins that play a critical role in triggering the germination of dormant spores in response to specific nutrient molecules. Here, we report the crystal structure of the C protein of the GerB germinant receptor, so-called GerBC, of Bacillus subtilis spores at 2.3 {angstrom} resolution. The GerBC protein adopts a previously uncharacterized type of protein fold consisting of three distinct domains, each of which is centered by a beta sheet surrounded by multiple alpha helices. Secondary-structure prediction and structure-based sequence alignment suggest that the GerBC structure represents the prototype for C subunits of nGRs from spores of all Bacillales and Clostridiales species and defines two highly conserved structural regions in this family of proteins. GerBC forms an interlocked dimer in the crystalline state but is predominantly monomeric in solution, pointing to the possibility that GerBC oligomerizes as a result of either high local protein concentrations or interaction with other nGR proteins in spores. Our findings provide the first structural view of the nGR subunits and a molecular framework for understanding the architecture, conservation, and function of nGRs.

  4. RecBC enzyme overproduction affects UV and gamma radiation survival of Deinococcus radiodurans.

    PubMed

    Khairnar, Nivedita P; Kamble, Vidya A; Misra, Hari S

    2008-01-01

    Deinococcus radiodurans recovering from the effect of acute dose of gamma (gamma) radiation shows a biphasic mechanism of DNA double strands breaks repair that involves an efficient homologous recombination. However, it shows higher sensitivity to near-UV (NUV) than Escherichia coli and lacks RecBC, a DNA strand break (DSB) repair enzyme in some bacteria. Recombinant Deinococcus expressing the recBC genes of E. coli showed nearly three-fold improvements in near-UV tolerance and nearly 2 log cycle reductions in wild type gamma radiation resistance. RecBC over expression effect on radiation response of D. radiodurans was independent of indigenous RecD. Loss of gamma radiation tolerance was attributed to the enhanced rate of in vivo degradation of radiation damaged DNA and delayed kinetics of DSB repair during post-irradiation recovery. RecBC expressing cells of Deinococcus showed wild type response to Far-UV. These results suggest that the overproduction of RecBC competes with the indigenous mechanism of gamma radiation damaged DNA repair while it supports near-UV tolerance in D. radiodurans. PMID:17720630

  5. Limited field investigation report for the 100-BC-5 Operable Unit

    SciTech Connect

    Not Available

    1994-07-01

    This limited field investigation (LFI) was conducted to assess the applicability of interim remedial measures (IRM) for reducing human health and environmental risks within the 100-BC-5 Groundwater Operable Unit. The 100-BC-5 Operable Unit is one of three operable units associated with the 100 B/C Area. Operable units 1 and 2 address contaminant sources while 100-BC-5 addresses contamination present in the underlying groundwater. The primary method of investigation used during this LFI was the installation of monitoring wells. Samples were collected from the groundwater and soils and submitted for laboratory analysis. Boreholes were surveyed for radiological contamination using downhole geophysical techniques to further delineate the locations and levels of contaminants. All samples were screened to ascertain the presence of volatile organic compounds and radionuclides. Analytical data were subjected to validation; all first round and 10% of the subsequent rounds of data associated with the LFI were validated. The screening method was used to identify contaminants of potential concern (COPC). This screening method eliminated from further consideration constituents that were below background. Constituents considered nontoxic to humans were eliminated from the human health evaluation. Inconsistency and blank contamination were also evaluated in the screening process. These COPC were evaluated further in the qualitative risk assessment (QRA). Tritium and strontium-90 were identified as contaminants of concern at 100-BC-5 because the concentrations exceeded potential applicable or relevant and appropriate requirements. The QRA determined that the risk is low for all of the site contaminants.

  6. Single-Particle Composition Measured in an Alpine Valley: Wood Smoke, EC and BC

    NASA Astrophysics Data System (ADS)

    Liepmann, C.; Gross, D. S.; Benzaid, S.; Christensen, J.; Turetsky, E.; Musicant, D.; Sandradewi, J.; Prevot, A.; Baltensperger, U.

    2007-12-01

    Particulate pollution is an issue of concern in today's society. Current regulations focus on the mass of particulate matter (PM) per volume of air, and not the source or chemical composition of the PM. Here we will present results from the AEROWOOD campaign in Roveredo, Switzerland where we investigated the PM composition measured using a single-particle mass spectrometer (TSI 3800 ATOFMS) to identify the sources of ambient particles. The goal was to differentiate wood smoke particles from diesel emissions. Roveredo is located in a deep alpine valley with strong wintertime thermal inversions, trapping the emissions. Local homes are predominantly heated by wood fires, and the village is located along a motorway that crosses the Swiss alps, providing two distinct particle sources. The particles sampled with the ATOFMS have been analyzed in a variety of ways with a focus on the temporal trends of the different particle types identified. Of particular interest is the distinction made between elemental carbon (EC) and black carbon (BC). During AEROWOOD, EC was measured chemically using real- time thermo/optical methods. BC was recorded directly by absorption, using an aethalometer. Regression models have been constructed to predict the EC and BC values using the single-particle mass spectra, providing chemical insight into the differences in these quantities. Additionally, comparing the timeline plots of EC, BC and the particle types found from the ATOFMS data should provide an idea as to the sources of EC and BC in this location.

  7. Flux, Budget and Sources of Black Carbon (BC) in the Continental Shelf of the Bohai and Yellow Seas, China

    NASA Astrophysics Data System (ADS)

    Fang, Y.; Chen, Y.; Tian, C.

    2015-12-01

    Black carbon (BC) derived from incomplete combustion of fossil fuels and biomass has received increasing attention due to their potential importance in a wide range of biogeochemical processes. China has been generally considered as the world's largest BC emitter. Due to a combination of the prevailing East Asia monsoon and large amounts of riverine outflow, BC released from China can be transported to the adjacent continental shelf seas, the Bohai Sea (BS) and Yellow Sea (YS). Based on measurements of BC in 191 surface sediments, 36 riverine water, and 2 seawater samples, as well as the reported BC data set of the aerosol samples in the Bohai Rim, the concentration, flux, and budget of BC in the BS and YS were investigated. The spatial distribution of the BC concentration in surface sediments was largely influenced by the regional hydrodynamic conditions, with high values mainly occurring in the central mud areas. The BC burial flux in the BS and YS ranged from 4 to 1100 μg/cm2/yr, and averaged 166 ± 200 μg/cm2/yr. The area-integrated sedimentary BC sink flux in the entire BS and YS was ~325 Gg/yr. The BC budget calculated in the BS showed that atmospheric deposition and riverine discharge played comparable importance in delivering BC to the BS, and sequestration to bottom sediments was the major BC output pattern, accounting for ~88% of the total input BC. Besides, we attempted to apportion the BC sources in the BS and YS surface sediments using PAHs (organic molecular proxies cogenerated with BC) and BC as an input data to the Positive Matrix Factorization (PMF) receptor model. Results showed that ~83% of the sediment BC was attributed to the combustion of fossil fuels, and the remaining ~17% was from biomass burning. Due to the differences in their production mechanisms and therefore physicochemical properties, the above distinction and quantification would help us better understand their different environmental behaviors in the complex continental shelf

  8. Measurement of the branching fraction ratio B (Bc+→ψ (2 S )π+)/B (Bc+→J /ψ π+)

    NASA Astrophysics Data System (ADS)

    Aaij, R.; Adeva, B.; Adinolfi, M.; Affolder, A.; Ajaltouni, Z.; Akar, S.; Albrecht, J.; Alessio, F.; Alexander, M.; Ali, S.; Alkhazov, G.; Alvarez Cartelle, P.; Alves, A. A.; Amato, S.; Amerio, S.; Amhis, Y.; An, L.; Anderson, J.; Andreassi, G.; Andreotti, M.; Andrews, J. E.; Appleby, R. B.; Aquines Gutierrez, O.; Archilli, F.; d'Argent, P.; Artamonov, A.; Artuso, M.; Aslanides, E.; Auriemma, G.; Baalouch, M.; Bachmann, S.; Back, J. J.; Badalov, A.; Baesso, C.; Baldini, W.; Barlow, R. J.; Barschel, C.; Barsuk, S.; Barter, W.; Batozskaya, V.; Battista, V.; Bay, A.; Beaucourt, L.; Beddow, J.; Bedeschi, F.; Bediaga, I.; Bel, L. J.; Bellee, V.; Belyaev, I.; Ben-Haim, E.; Bencivenni, G.; Benson, S.; Benton, J.; Berezhnoy, A.; Bernet, R.; Bertolin, A.; Bettler, M.-O.; van Beuzekom, M.; Bien, A.; Bifani, S.; Bird, T.; Birnkraut, A.; Bizzeti, A.; Blake, T.; Blanc, F.; Blouw, J.; Blusk, S.; Bocci, V.; Bondar, A.; Bondar, N.; Bonivento, W.; Borghi, S.; Borsato, M.; Bowcock, T. J. V.; Bowen, E.; Bozzi, C.; Braun, S.; Brett, D.; Britsch, M.; Britton, T.; Brodzicka, J.; Brook, N. H.; Bursche, A.; Buytaert, J.; Cadeddu, S.; Calabrese, R.; Calvi, M.; Calvo Gomez, M.; Campana, P.; Campora Perez, D.; Capriotti, L.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carniti, P.; Carson, L.; Carvalho Akiba, K.; Casse, G.; Cassina, L.; Castillo Garcia, L.; Cattaneo, M.; Cauet, Ch.; Cavallero, G.; Cenci, R.; Charles, M.; Charpentier, Ph.; Chefdeville, M.; Chen, S.; Cheung, S.-F.; Chiapolini, N.; Chrzaszcz, M.; Cid Vidal, X.; Ciezarek, G.; Clarke, P. E. L.; Clemencic, M.; Cliff, H. V.; Closier, J.; Coco, V.; Cogan, J.; Cogneras, E.; Cogoni, V.; Cojocariu, L.; Collazuol, G.; Collins, P.; Comerma-Montells, A.; Contu, A.; Cook, A.; Coombes, M.; Coquereau, S.; Corti, G.; Corvo, M.; Couturier, B.; Cowan, G. A.; Craik, D. C.; Crocombe, A.; Cruz Torres, M.; Cunliffe, S.; Currie, R.; D'Ambrosio, C.; Dall'Occo, E.; Dalseno, J.; David, P. N. Y.; Davis, A.; De Bruyn, K.; De Capua, S.; De Cian, M.; De Miranda, J. M.; De Paula, L.; De Simone, P.; Dean, C.-T.; Decamp, D.; Deckenhoff, M.; Del Buono, L.; Déléage, N.; Demmer, M.; Derkach, D.; Deschamps, O.; Dettori, F.; Dey, B.; Di Canto, A.; Di Ruscio, F.; Dijkstra, H.; Donleavy, S.; Dordei, F.; Dorigo, M.; Dosil Suárez, A.; Dossett, D.; Dovbnya, A.; Dreimanis, K.; Dufour, L.; Dujany, G.; Dupertuis, F.; Durante, P.; Dzhelyadin, R.; Dziurda, A.; Dzyuba, A.; Easo, S.; Egede, U.; Egorychev, V.; Eidelman, S.; Eisenhardt, S.; Eitschberger, U.; Ekelhof, R.; Eklund, L.; El Rifai, I.; Elsasser, Ch.; Ely, S.; Esen, S.; Evans, H. M.; Evans, T.; Falabella, A.; Färber, C.; Farinelli, C.; Farley, N.; Farry, S.; Fay, R.; Ferguson, D.; Fernandez Albor, V.; Ferrari, F.; Ferreira Rodrigues, F.; Ferro-Luzzi, M.; Filippov, S.; Fiore, M.; Fiorini, M.; Firlej, M.; Fitzpatrick, C.; Fiutowski, T.; Fohl, K.; Fol, P.; Fontana, M.; Fontanelli, F.; Forty, R.; Francisco, O.; Frank, M.; Frei, C.; Frosini, M.; Fu, J.; Furfaro, E.; Gallas Torreira, A.; Galli, D.; Gallorini, S.; Gambetta, S.; Gandelman, M.; Gandini, P.; Gao, Y.; García Pardiñas, J.; Garra Tico, J.; Garrido, L.; Gascon, D.; Gaspar, C.; Gauld, R.; Gavardi, L.; Gazzoni, G.; Geraci, A.; Gerick, D.; Gersabeck, E.; Gersabeck, M.; Gershon, T.; Ghez, Ph.; Gianelle, A.; Gianı, S.; Gibson, V.; Girard, O. G.; Giubega, L.; Gligorov, V. V.; Göbel, C.; Golubkov, D.; Golutvin, A.; Gomes, A.; Gotti, C.; Grabalosa Gándara, M.; Graciani Diaz, R.; Granado Cardoso, L. A.; Graugés, E.; Graverini, E.; Graziani, G.; Grecu, A.; Greening, E.; Gregson, S.; Griffith, P.; Grillo, L.; Grünberg, O.; Gui, B.; Gushchin, E.; Guz, Yu.; Gys, T.; Hadavizadeh, T.; Hadjivasiliou, C.; Haefeli, G.; Haen, C.; Haines, S. C.; Hall, S.; Hamilton, B.; Han, X.; Hansmann-Menzemer, S.; Harnew, N.; Harrison, J.; He, J.; Head, T.; Heijne, V.; Hennessy, K.; Henrard, P.; Henry, L.; Hernando Morata, J. A.; van Herwijnen, E.; Heß, M.; Hicheur, A.; Hill, D.; Hoballah, M.; Hombach, C.; Hulsbergen, W.; Humair, T.; Hussain, N.; Hutchcroft, D.; Hynds, D.; Idzik, M.; Ilten, P.; Jacobsson, R.; Jaeger, A.; Jalocha, J.; Jans, E.; Jawahery, A.; Jing, F.; John, M.; Johnson, D.; Jones, C. R.; Joram, C.; Jost, B.; Jurik, N.; Kandybei, S.; Kanso, W.; Karacson, M.; Karbach, T. M.; Karodia, S.; Kelsey, M.; Kenyon, I. R.; Kenzie, M.; Ketel, T.; Khanji, B.; Khurewathanakul, C.; Klaver, S.; Klimaszewski, K.; Kochebina, O.; Kolpin, M.; Komarov, I.; Koopman, R. F.; Koppenburg, P.; Kozeiha, M.; Kravchuk, L.; Kreplin, K.; Kreps, M.; Krocker, G.; Krokovny, P.; Kruse, F.; Kucewicz, W.; Kucharczyk, M.; Kudryavtsev, V.; Kuonen, A. K.; Kurek, K.; Kvaratskheliya, T.; Lacarrere, D.; Lafferty, G.; Lai, A.; Lambert, D.; Lanfranchi, G.; Langenbruch, C.; Langhans, B.; Latham, T.; Lazzeroni, C.; Le Gac, R.; van Leerdam, J.; Lees, J.-P.; Lefèvre, R.; Leflat, A.; Lefrançois, J.; Leroy, O.; Lesiak, T.; Leverington, B.; Li, Y.; Likhomanenko, T.; Liles, M.; Lindner, R.; Linn, C.; Lionetto, F.; Liu, B.; Liu, X.; Loh, D.; Lohn, S.; Longstaff, I.; Lopes, J. H.; Lucchesi, D.; Lucio Martinez, M.; Luo, H.; Lupato, A.; Luppi, E.; Lupton, O.; Lusardi, N.; Lusiani, A.; Machefert, F.; Maciuc, F.; Maev, O.; Maguire, K.; Malde, S.; Malinin, A.; Manca, G.; Mancinelli, G.; Manning, P.; Mapelli, A.; Maratas, J.; Marchand, J. F.; Marconi, U.; Marin Benito, C.; Marino, P.; Märki, R.; Marks, J.; Martellotti, G.; Martin, M.; Martinelli, M.; Martinez Santos, D.; Martinez Vidal, F.; Martins Tostes, D.; Massafferri, A.; Matev, R.; Mathad, A.; Mathe, Z.; Matteuzzi, C.; Matthieu, K.; Mauri, A.; Maurin, B.; Mazurov, A.; McCann, M.; McCarthy, J.; McNab, A.; McNulty, R.; Meadows, B.; Meier, F.; Meissner, M.; Melnychuk, D.; Merk, M.; Milanes, D. A.; Minard, M.-N.; Mitzel, D. S.; Molina Rodriguez, J.; Monroy, I. A.; Monteil, S.; Morandin, M.; Morawski, P.; Mordà, A.; Morello, M. J.; Moron, J.; Morris, A. B.; Mountain, R.; Muheim, F.; Müller, J.; Müller, K.; Müller, V.; Mussini, M.; Muster, B.; Naik, P.; Nakada, T.; Nandakumar, R.; Nandi, A.; Nasteva, I.; Needham, M.; Neri, N.; Neubert, S.; Neufeld, N.; Neuner, M.; Nguyen, A. D.; Nguyen, T. D.; Nguyen-Mau, C.; Niess, V.; Niet, R.; Nikitin, N.; Nikodem, T.; Ninci, D.; Novoselov, A.; O'Hanlon, D. P.; Oblakowska-Mucha, A.; Obraztsov, V.; Ogilvy, S.; Okhrimenko, O.; Oldeman, R.; Onderwater, C. J. G.; Osorio Rodrigues, B.; Otalora Goicochea, J. M.; Otto, A.; Owen, P.; Oyanguren, A.; Palano, A.; Palombo, F.; Palutan, M.; Panman, J.; Papanestis, A.; Pappagallo, M.; Pappalardo, L. L.; Pappenheimer, C.; Parkes, C.; Passaleva, G.; Patel, G. D.; Patel, M.; Patrignani, C.; Pearce, A.; Pellegrino, A.; Penso, G.; Pepe Altarelli, M.; Perazzini, S.; Perret, P.; Pescatore, L.; Petridis, K.; Petrolini, A.; Petruzzo, M.; Picatoste Olloqui, E.; Pietrzyk, B.; Pilař, T.; Pinci, D.; Pistone, A.; Piucci, A.; Playfer, S.; Plo Casasus, M.; Poikela, T.; Polci, F.; Poluektov, A.; Polyakov, I.; Polycarpo, E.; Popov, A.; Popov, D.; Popovici, B.; Potterat, C.; Price, E.; Price, J. D.; Prisciandaro, J.; Pritchard, A.; Prouve, C.; Pugatch, V.; Puig Navarro, A.; Punzi, G.; Qian, W.; Quagliani, R.; Rachwal, B.; Rademacker, J. H.; Rama, M.; Rangel, M. S.; Raniuk, I.; Rauschmayr, N.; Raven, G.; Redi, F.; Reichert, S.; Reid, M. M.; dos Reis, A. C.; Ricciardi, S.; Richards, S.; Rihl, M.; Rinnert, K.; Rives Molina, V.; Robbe, P.; Rodrigues, A. B.; Rodrigues, E.; Rodriguez Lopez, J. A.; Rodriguez Perez, P.; Roiser, S.; Romanovsky, V.; Romero Vidal, A.; Ronayne, J. W.; Rotondo, M.; Rouvinet, J.; Ruf, T.; Ruiz, H.; Ruiz Valls, P.; Saborido Silva, J. J.; Sagidova, N.; Sail, P.; Saitta, B.; Salustino Guimaraes, V.; Sanchez Mayordomo, C.; Sanmartin Sedes, B.; Santacesaria, R.; Santamarina Rios, C.; Santimaria, M.; Santovetti, E.; Sarti, A.; Satriano, C.; Satta, A.; Saunders, D. M.; Savrina, D.; Schiller, M.; Schindler, H.; Schlupp, M.; Schmelling, M.; Schmelzer, T.; Schmidt, B.; Schneider, O.; Schopper, A.; Schubiger, M.; Schune, M.-H.; Schwemmer, R.; Sciascia, B.; Sciubba, A.; Semennikov, A.; Serra, N.; Serrano, J.; Sestini, L.; Seyfert, P.; Shapkin, M.; Shapoval, I.; Shcheglov, Y.; Shears, T.; Shekhtman, L.; Shevchenko, V.; Shires, A.; Siddi, B. G.; Silva Coutinho, R.; Simi, G.; Sirendi, M.; Skidmore, N.; Skillicorn, I.; Skwarnicki, T.; Smith, E.; Smith, E.; Smith, I. T.; Smith, J.; Smith, M.; Snoek, H.; Sokoloff, M. D.; Soler, F. J. P.; Soomro, F.; Souza, D.; Souza De Paula, B.; Spaan, B.; Spradlin, P.; Sridharan, S.; Stagni, F.; Stahl, M.; Stahl, S.; Steinkamp, O.; Stenyakin, O.; Sterpka, F.; Stevenson, S.; Stoica, S.; Stone, S.; Storaci, B.; Stracka, S.; Straticiuc, M.; Straumann, U.; Sun, L.; Sutcliffe, W.; Swientek, K.; Swientek, S.; Syropoulos, V.; Szczekowski, M.; Szczypka, P.; Szumlak, T.; T'Jampens, S.; Tayduganov, A.; Tekampe, T.; Teklishyn, M.; Tellarini, G.; Teubert, F.; Thomas, C.; Thomas, E.; van Tilburg, J.; Tisserand, V.; Tobin, M.; Todd, J.; Tolk, S.; Tomassetti, L.; Tonelli, D.; Topp-Joergensen, S.; Torr, N.; Tournefier, E.; Tourneur, S.; Trabelsi, K.; Tran, M. T.; Tresch, M.; Trisovic, A.; Tsaregorodtsev, A.; Tsopelas, P.; Tuning, N.; Ukleja, A.; Ustyuzhanin, A.; Uwer, U.; Vacca, C.; Vagnoni, V.; Valenti, G.; Vallier, A.; Vazquez Gomez, R.; Vazquez Regueiro, P.; Vázquez Sierra, C.; Vecchi, S.; Velthuis, J. J.; Veltri, M.; Veneziano, G.; Vesterinen, M.; Viaud, B.; Vieira, D.; Vieites Diaz, M.; Vilasis-Cardona, X.; Vollhardt, A.; Volyanskyy, D.; Voong, D.; Vorobyev, A.; Vorobyev, V.; Voß, C.; de Vries, J. A.; Waldi, R.; Wallace, C.; Wallace, R.; Walsh, J.; Wandernoth, S.; Wang, J.; Ward, D. R.; Watson, N. K.; Websdale, D.; Weiden, A.; Whitehead, M.; Wilkinson, G.; Wilkinson, M.; Williams, M.; Williams, M. P.; Williams, M.; Williams, T.; Wilson, F. F.; Wimberley, J.; Wishahi, J.; Wislicki, W.; Witek, M.; Wormser, G.; Wotton, S. A.; Wright, S.; Wyllie, K.; Xie, Y.; Xu, Z.; Yang, Z.; Yu, J.; Yuan, X.; Yushchenko, O.; Zangoli, M.; Zavertyaev, M.; Zhang, L.; Zhang, Y.; Zhelezov, A.; Zhokhov, A.; Zhong, L.; Zucchelli, S.; LHCb Collaboration

    2015-10-01

    Using p p collision data collected by LHCb at center-of-mass energies √{s } =7 TeV and 8 TeV, corresponding to an integrated luminosity of 3 fb-1 , the ratio of the branching fraction of the Bc+→ψ (2 S ) π+ decay relative to that of the Bc+→J /ψ π+ decay is measured to be 0.268 ±0.032 (stat ) ±0.007 (syst ) ±0.006 (BF ) . The first uncertainty is statistical, the second is systematic, and the third is due to the uncertainties on the branching fractions of the J /ψ →μ+μ- and ψ (2 S ) →μ+μ- decays. This measurement is consistent with the previous LHCb result, and the statistical uncertainty is halved.

  9. Reconstructing the epidemic history of HIV-1 circulating recombinant forms CRF07_BC and CRF08_BC in East Asia: the relevance of genetic diversity and phylodynamics for vaccine strategies.

    PubMed

    Takebe, Yutaka; Liao, Huanan; Hase, Saiki; Uenishi, Rie; Li, Yue; Li, Xiao-Jie; Han, Xiaoxu; Shang, Hong; Kamarulzaman, Adeeba; Yamamoto, Naoki; Pybus, Oliver G; Tee, Kok Keng

    2010-05-26

    HIV-1 CRF07_BC and CRF08_BC are closely related circulating recombinant forms (CRFs) with serious public health consequences in China. The temporal and spatial dynamics of these CRFs were determined by estimating their times of divergence, using phylogenetic and Bayesian coalescent methods. Studies of the timelines of CRF07_BC and CRF08_BC trace the expansion of these strains back their origins to Yunnan province. The present study highlights the relevance of incorporating evolutionary and molecular epidemiological analyses into an in-depth understanding of the genesis of HIV epidemic, providing information for determining regional and global public health policies, including future vaccine strategies. PMID:20510742

  10. Characterization of liquid scintillation detector (BC-501A) and digital pulse shape discrimination (DPSD) system

    SciTech Connect

    Lombigit, L. Yussup, N. Ibrahim, Maslina Mohd; Rahman, Nur Aira Abd; Rawi, M. Z. M.

    2015-04-29

    A digital n/γ pulse shape discrimination (PSD) system is currently under development at Instrumentation and Automation Centre, Malaysian Nuclear Agency. This system aims at simultaneous detection of fast neutron and gamma ray in mixed radiations environment. This work reports the system characterization performed on the liquid scintillation detector (BC-501A) and digital pulse shape discrimination (DPSD) system. The characterization involves measurement of electron light output from the BC-501A detector and energy channels calibration of the pulse height spectra acquired with DPSD system using set of photon reference sources. The main goal of this experiment is to calibrate the ADC channel of our DPSD system, characterized the BC-501 detector and find the position of Compton edge which later could be used as threshold for the n/γ PSD experiment. The detector resolution however is worse as compared to other published data but it is expected as our detector has a smaller active volume.

  11. Search for Bc+ decays to the p p ‾π+ final state

    NASA Astrophysics Data System (ADS)

    Aaij, R.; Abellán Beteta, C.; Adeva, B.; Adinolfi, M.; Ajaltouni, Z.; Akar, S.; Albrecht, J.; Alessio, F.; Alexander, M.; Ali, S.; Alkhazov, G.; Alvarez Cartelle, P.; Alves, A. A.; Amato, S.; Amerio, S.; Amhis, Y.; An, L.; Anderlini, L.; Andreassi, G.; Andreotti, M.; Andrews, J. E.; Appleby, R. B.; Aquines Gutierrez, O.; Archilli, F.; d'Argent, P.; Artamonov, A.; Artuso, M.; Aslanides, E.; Auriemma, G.; Baalouch, M.; Bachmann, S.; Back, J. J.; Badalov, A.; Baesso, C.; Baker, S.; Baldini, W.; Barlow, R. J.; Barschel, C.; Barsuk, S.; Barter, W.; Batozskaya, V.; Battista, V.; Bay, A.; Beaucourt, L.; Beddow, J.; Bedeschi, F.; Bediaga, I.; Bel, L. J.; Bellee, V.; Belloli, N.; Belyaev, I.; Ben-Haim, E.; Bencivenni, G.; Benson, S.; Benton, J.; Berezhnoy, A.; Bernet, R.; Bertolin, A.; Betti, F.; Bettler, M.-O.; van Beuzekom, M.; Bifani, S.; Billoir, P.; Bird, T.; Birnkraut, A.; Bizzeti, A.; Blake, T.; Blanc, F.; Blouw, J.; Blusk, S.; Bocci, V.; Bondar, A.; Bondar, N.; Bonivento, W.; Borgheresi, A.; Borghi, S.; Borisyak, M.; Borsato, M.; Boubdir, M.; Bowcock, T. J. V.; Bowen, E.; Bozzi, C.; Braun, S.; Britsch, M.; Britton, T.; Brodzicka, J.; Buchanan, E.; Burr, C.; Bursche, A.; Buytaert, J.; Cadeddu, S.; Calabrese, R.; Calvi, M.; Calvo Gomez, M.; Campana, P.; Campora Perez, D.; Capriotti, L.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carniti, P.; Carson, L.; Carvalho Akiba, K.; Casse, G.; Cassina, L.; Castillo Garcia, L.; Cattaneo, M.; Cauet, Ch.; Cavallero, G.; Cenci, R.; Charles, M.; Charpentier, Ph.; Chatzikonstantinidis, G.; Chefdeville, M.; Chen, S.; Cheung, S.-F.; Chrzaszcz, M.; Cid Vidal, X.; Ciezarek, G.; Clarke, P. E. L.; Clemencic, M.; Cliff, H. V.; Closier, J.; Coco, V.; Cogan, J.; Cogneras, E.; Cogoni, V.; Cojocariu, L.; Collazuol, G.; Collins, P.; Comerma-Montells, A.; Contu, A.; Cook, A.; Coombes, M.; Coquereau, S.; Corti, G.; Corvo, M.; Couturier, B.; Cowan, G. A.; Craik, D. C.; Crocombe, A.; Cruz Torres, M.; Cunliffe, S.; Currie, R.; D'Ambrosio, C.; Dall'Occo, E.; Dalseno, J.; David, P. N. Y.; Davis, A.; De Aguiar Francisco, O.; De Bruyn, K.; De Capua, S.; De Cian, M.; De Miranda, J. M.; De Paula, L.; De Simone, P.; Dean, C.-T.; Decamp, D.; Deckenhoff, M.; Del Buono, L.; Déléage, N.; Demmer, M.; Derkach, D.; Deschamps, O.; Dettori, F.; Dey, B.; Di Canto, A.; Di Ruscio, F.; Dijkstra, H.; Dordei, F.; Dorigo, M.; Dosil Suárez, A.; Dovbnya, A.; Dreimanis, K.; Dufour, L.; Dujany, G.; Dungs, K.; Durante, P.; Dzhelyadin, R.; Dziurda, A.; Dzyuba, A.; Easo, S.; Egede, U.; Egorychev, V.; Eidelman, S.; Eisenhardt, S.; Eitschberger, U.; Ekelhof, R.; Eklund, L.; El Rifai, I.; Elsasser, Ch.; Ely, S.; Esen, S.; Evans, H. M.; Evans, T.; Falabella, A.; Färber, C.; Farley, N.; Farry, S.; Fay, R.; Fazzini, D.; Ferguson, D.; Fernandez Albor, V.; Ferrari, F.; Ferreira Rodrigues, F.; Ferro-Luzzi, M.; Filippov, S.; Fiore, M.; Fiorini, M.; Firlej, M.; Fitzpatrick, C.; Fiutowski, T.; Fleuret, F.; Fohl, K.; Fontana, M.; Fontanelli, F.; Forshaw, D. C.; Forty, R.; Frank, M.; Frei, C.; Frosini, M.; Fu, J.; Furfaro, E.; Gallas Torreira, A.; Galli, D.; Gallorini, S.; Gambetta, S.; Gandelman, M.; Gandini, P.; Gao, Y.; García Pardiñas, J.; Garra Tico, J.; Garrido, L.; Garsed, P. J.; Gascon, D.; Gaspar, C.; Gavardi, L.; Gazzoni, G.; Gerick, D.; Gersabeck, E.; Gersabeck, M.; Gershon, T.; Ghez, Ph.; Gianì, S.; Gibson, V.; Girard, O. G.; Giubega, L.; Gligorov, V. V.; Göbel, C.; Golubkov, D.; Golutvin, A.; Gomes, A.; Gotti, C.; Grabalosa Gándara, M.; Graciani Diaz, R.; Granado Cardoso, L. A.; Graugés, E.; Graverini, E.; Graziani, G.; Grecu, A.; Griffith, P.; Grillo, L.; Grünberg, O.; Gui, B.; Gushchin, E.; Guz, Yu.; Gys, T.; Hadavizadeh, T.; Hadjivasiliou, C.; Haefeli, G.; Haen, C.; Haines, S. C.; Hall, S.; Hamilton, B.; Han, X.; Hansmann-Menzemer, S.; Harnew, N.; Harnew, S. T.; Harrison, J.; He, J.; Head, T.; Heister, A.; Hennessy, K.; Henrard, P.; Henry, L.; Hernando Morata, J. A.; van Herwijnen, E.; Heß, M.; Hicheur, A.; Hill, D.; Hoballah, M.; Hombach, C.; Hongming, L.; Hulsbergen, W.; Humair, T.; Hushchyn, M.; Hussain, N.; Hutchcroft, D.; Idzik, M.; Ilten, P.; Jacobsson, R.; Jaeger, A.; Jalocha, J.; Jans, E.; Jawahery, A.; John, M.; Johnson, D.; Jones, C. R.; Joram, C.; Jost, B.; Jurik, N.; Kandybei, S.; Kanso, W.; Karacson, M.; Karbach, T. M.; Karodia, S.; Kecke, M.; Kelsey, M.; Kenyon, I. R.; Kenzie, M.; Ketel, T.; Khairullin, E.; Khanji, B.; Khurewathanakul, C.; Kirn, T.; Klaver, S.; Klimaszewski, K.; Kolpin, M.; Komarov, I.; Koopman, R. F.; Koppenburg, P.; Kozeiha, M.; Kravchuk, L.; Kreplin, K.; Kreps, M.; Krokovny, P.; Kruse, F.; Krzemien, W.; Kucewicz, W.; Kucharczyk, M.; Kudryavtsev, V.; Kuonen, A. K.; Kurek, K.; Kvaratskheliya, T.; Lacarrere, D.; Lafferty, G.; Lai, A.; Lambert, D.; Lanfranchi, G.; Langenbruch, C.; Langhans, B.; Latham, T.; Lazzeroni, C.; Le Gac, R.; van Leerdam, J.; Lees, J.-P.; Lefèvre, R.; Leflat, A.; Lefrançois, J.; Lemos Cid, E.; Leroy, O.; Lesiak, T.; Leverington, B.; Li, Y.; Likhomanenko, T.; Lindner, R.; Linn, C.; Lionetto, F.; Liu, B.; Liu, X.; Loh, D.; Longstaff, I.; Lopes, J. H.; Lucchesi, D.; Lucio Martinez, M.; Luo, H.; Lupato, A.; Luppi, E.; Lupton, O.; Lusardi, N.; Lusiani, A.; Lyu, X.; Machefert, F.; Maciuc, F.; Maev, O.; Maguire, K.; Malde, S.; Malinin, A.; Manca, G.; Mancinelli, G.; Manning, P.; Mapelli, A.; Maratas, J.; Marchand, J. F.; Marconi, U.; Marin Benito, C.; Marino, P.; Marks, J.; Martellotti, G.; Martin, M.; Martinelli, M.; Martinez Santos, D.; Martinez Vidal, F.; Martins Tostes, D.; Massacrier, L. M.; Massafferri, A.; Matev, R.; Mathad, A.; Mathe, Z.; Matteuzzi, C.; Mauri, A.; Maurin, B.; Mazurov, A.; McCann, M.; McCarthy, J.; McNab, A.; McNulty, R.; Meadows, B.; Meier, F.; Meissner, M.; Melnychuk, D.; Merk, M.; Merli, A.; Michielin, E.; Milanes, D. A.; Minard, M.-N.; Mitzel, D. S.; Molina Rodriguez, J.; Monroy, I. A.; Monteil, S.; Morandin, M.; Morawski, P.; Mordà, A.; Morello, M. J.; Moron, J.; Morris, A. B.; Mountain, R.; Muheim, F.; Müller, D.; Müller, J.; Müller, K.; Müller, V.; Mussini, M.; Muster, B.; Naik, P.; Nakada, T.; Nandakumar, R.; Nandi, A.; Nasteva, I.; Needham, M.; Neri, N.; Neubert, S.; Neufeld, N.; Neuner, M.; Nguyen, A. D.; Nguyen-Mau, C.; Niess, V.; Nieswand, S.; Niet, R.; Nikitin, N.; Nikodem, T.; Novoselov, A.; O'Hanlon, D. P.; Oblakowska-Mucha, A.; Obraztsov, V.; Ogilvy, S.; Okhrimenko, O.; Oldeman, R.; Onderwater, C. J. G.; Osorio Rodrigues, B.; Otalora Goicochea, J. M.; Otto, A.; Owen, P.; Oyanguren, A.; Palano, A.; Palombo, F.; Palutan, M.; Panman, J.; Papanestis, A.; Pappagallo, M.; Pappalardo, L. L.; Pappenheimer, C.; Parker, W.; Parkes, C.; Passaleva, G.; Patel, G. D.; Patel, M.; Patrignani, C.; Pearce, A.; Pellegrino, A.; Penso, G.; Pepe Altarelli, M.; Perazzini, S.; Perret, P.; Pescatore, L.; Petridis, K.; Petrolini, A.; Petruzzo, M.; Picatoste Olloqui, E.; Pietrzyk, B.; Pikies, M.; Pinci, D.; Pistone, A.; Piucci, A.; Playfer, S.; Plo Casasus, M.; Poikela, T.; Polci, F.; Poluektov, A.; Polyakov, I.; Polycarpo, E.; Popov, A.; Popov, D.; Popovici, B.; Potterat, C.; Price, E.; Price, J. D.; Prisciandaro, J.; Pritchard, A.; Prouve, C.; Pugatch, V.; Puig Navarro, A.; Punzi, G.; Qian, W.; Quagliani, R.; Rachwal, B.; Rademacker, J. H.; Rama, M.; Ramos Pernas, M.; Rangel, M. S.; Raniuk, I.; Raven, G.; Redi, F.; Reichert, S.; dos Reis, A. C.; Renaudin, V.; Ricciardi, S.; Richards, S.; Rihl, M.; Rinnert, K.; Rives Molina, V.; Robbe, P.; Rodrigues, A. B.; Rodrigues, E.; Rodriguez Lopez, J. A.; Rodriguez Perez, P.; Rogozhnikov, A.; Roiser, S.; Romanovsky, V.; Romero Vidal, A.; Ronayne, J. W.; Rotondo, M.; Ruf, T.; Ruiz Valls, P.; Saborido Silva, J. J.; Sagidova, N.; Saitta, B.; Salustino Guimaraes, V.; Sanchez Mayordomo, C.; Sanmartin Sedes, B.; Santacesaria, R.; Santamarina Rios, C.; Santimaria, M.; Santovetti, E.; Sarti, A.; Satriano, C.; Satta, A.; Saunders, D. M.; Savrina, D.; Schael, S.; Schiller, M.; Schindler, H.; Schlupp, M.; Schmelling, M.; Schmelzer, T.; Schmidt, B.; Schneider, O.; Schopper, A.; Schubiger, M.; Schune, M.-H.; Schwemmer, R.; Sciascia, B.; Sciubba, A.; Semennikov, A.; Sergi, A.; Serra, N.; Serrano, J.; Sestini, L.; Seyfert, P.; Shapkin, M.; Shapoval, I.; Shcheglov, Y.; Shears, T.; Shekhtman, L.; Shevchenko, V.; Shires, A.; Siddi, B. G.; Silva Coutinho, R.; Silva de Oliveira, L.; Simi, G.; Sirendi, M.; Skidmore, N.; Skwarnicki, T.; Smith, E.; Smith, I. T.; Smith, J.; Smith, M.; Snoek, H.; Sokoloff, M. D.; Soler, F. J. P.; Soomro, F.; Souza, D.; Souza De Paula, B.; Spaan, B.; Spradlin, P.; Sridharan, S.; Stagni, F.; Stahl, M.; Stahl, S.; Stefkova, S.; Steinkamp, O.; Stenyakin, O.; Stevenson, S.; Stoica, S.; Stone, S.; Storaci, B.; Stracka, S.; Straticiuc, M.; Straumann, U.; Sun, L.; Sutcliffe, W.; Swientek, K.; Swientek, S.; Syropoulos, V.; Szczekowski, M.; Szumlak, T.; T'Jampens, S.; Tayduganov, A.; Tekampe, T.; Tellarini, G.; Teubert, F.; Thomas, C.; Thomas, E.; van Tilburg, J.; Tisserand, V.; Tobin, M.; Tolk, S.; Tomassetti, L.; Tonelli, D.; Topp-Joergensen, S.; Tournefier, E.; Tourneur, S.; Trabelsi, K.; Traill, M.; Tran, M. T.; Tresch, M.; Trisovic, A.; Tsaregorodtsev, A.; Tsopelas, P.; Tuning, N.; Ukleja, A.; Ustyuzhanin, A.; Uwer, U.; Vacca, C.; Vagnoni, V.; Valat, S.; Valenti, G.; Vallier, A.; Vazquez Gomez, R.; Vazquez Regueiro, P.; Vázquez Sierra, C.; Vecchi, S.; van Veghel, M.; Velthuis, J. J.; Veltri, M.; Veneziano, G.; Vesterinen, M.; Viaud, B.; Vieira, D.; Vieites Diaz, M.; Vilasis-Cardona, X.; Volkov, V.; Vollhardt, A.; Voong, D.; Vorobyev, A.; Vorobyev, V.; Voß, C.; de Vries, J. A.; Waldi, R.; Wallace, C.; Wallace, R.; Walsh, J.; Wang, J.; Ward, D. R.; Watson, N. K.; Websdale, D.; Weiden, A.; Whitehead, M.; Wicht, J.; Wilkinson, G.; Wilkinson, M.; Williams, M.; Williams, M. P.; Williams, M.; Williams, T.; Wilson, F. F.; Wimberley, J.; Wishahi, J.; Wislicki, W.; Witek, M.; Wormser, G.; Wotton, S. A.; Wraight, K.; Wright, S.; Wyllie, K.; Xie, Y.; Xu, Z.; Yang, Z.; Yin, H.; Yu, J.; Yuan, X.; Yushchenko, O.; Zangoli, M.; Zavertyaev, M.; Zhang, L.; Zhang, Y.; Zhelezov, A.; Zheng, Y.; Zhokhov, A.; Zhong, L.; Zhukov, V.; Zucchelli, S.

    2016-08-01

    A search for the decays of the Bc+ meson to p p bar π+ is performed for the first time using a data sample corresponding to an integrated luminosity of 3.0 fb-1 collected by the LHCb experiment in pp collisions at centre-of-mass energies of 7 and 8 TeV. No signal is found and an upper limit, at 95% confidence level, is set, fc/fu × B (Bc+ → p p ‾π+) < 3.6 ×10-8 in the kinematic region m (p p ‾) < 2.85 GeV /c2, pT (B) < 20 GeV / c and 2.0 < y (B) < 4.5, where B is the branching fraction and fc (fu) is the fragmentation fraction of the b quark into a Bc + (B+) meson.

  12. Rapid landscape change in 6th century Jordan: driven by climate or man-made?

    NASA Astrophysics Data System (ADS)

    Lucke, Bernhard

    2014-05-01

    Compared to the rich cities of antiquity, many areas in the Levant appear today degraded. European travel reports of the 19th century and excavations in Jordan created the impression that population numbers were strongly reduced during the Islamic periods, leading to 'empty' lands which were only resettled during the early 20th century. However, our case study near the ancient site Abila of the Decapolis in northern Jordan found that the land was probably never 'empty' and always fertile - but valley fills provide evidence for a rapid and intense landscape change during the Late Byzantine period. This was probably caused by a significant shift to aridity which also triggered socio-economic changes of subsistence strategies from agriculture to pastoralism. The dates of sediments which are available so far indicate that the climatic change seemingly occurred rapidly within approximately 100 years during the late 6th and early 7th century AD, and rubble layers let it seem probable that it was associated with frequent heavy rainfall events. It might have been caused or triggered by a global climate event creating the "year without sun" or 'Mystery Veil' which the Byzantine historian Procopius described in the year 536 AD. If similar events repeat under the current climate change, it will be difficult to mitigate them.

  13. Development of an improved optical transmission technique for black carbon (BC) analysis

    NASA Astrophysics Data System (ADS)

    Ballach, J.; Hitzenberger, R.; Schultz, E.; Jaeschke, W.

    A new optical transmission technique for black carbon (BC) analysis was developed to minimize interferences due to scattering effects in filter samples. A standard thermal analysis method (VDI, 1999) is used to link light attenuation by the filter samples to elemental carbon (EC) concentration. Scattering effects are minimized by immersion of the filters in oil of a similar refractive index, as is often done for microscopy purposes. Light attenuation was measured using both a white light source and a red LED of 650 nm. The usual increase in overestimation of BC concentrations with decreasing BC amount in filter samples was found considerably reduced. Some effects of BC properties (e.g. fractal dimension, microstructure and size distribution) on the specific attenuation coefficient BATN, however, are still present for the treated samples. BATN was found close to 1 m 2 g -1 for dry-dispersed industrial BC and 7 m 2 g -1 for nebulized BC. Good agreement was found between the oil immersion, integrating sphere and a polar photometer technique and Mie calculations. The average specific attenuation coefficient of ambient samples in oil varied between 7 and 11 m 2 g -1 for white light and 6 and 9 m 2 g -1 for red light (LED). BATN was found to have much less site variation for the treated than for the untreated samples. The oil immersion technique improved also the correlation with thermally analyzed EC. This new immersion technique therefore presents a considerable improvement over conventional optical transmission techniques and may therefore serve as a simple, fast and cost-effective alternative to thermal methods.

  14. Ascochlorin is a novel, specific inhibitor of the mitochondrial cytochrome bc1 complex

    PubMed Central

    Berry, Edward A.; Huang, Li-shar; Lee, Dong-Woo; Daldal, Fevzi; Nagai, Kazuo; Minagawa, Nobuko

    2009-01-01

    Ascochlorin is an isoprenoid antibiotic that is produced by the phytopathogenic fungus Ascochyta viciae. Similar to ascofuranone, which specifically inhibits trypanosome alternative oxidase by acting at the ubiquinol binding domain, ascochlorin is also structurally related to ubiquinol. When added to the mitochondrial preparations isolated from rat liver, or the yeast Pichia (Hansenula) anomala, ascochlorin inhibited the electron transport via CoQ in a fashion comparable to antimycin A and stigmatellin, indicating that this antibiotic acted on the cytochrome bc1 complex. In contrast to ascochlorin, ascofuranone had much less inhibition on the same activities. On the one hand, like the Qi site inhibitors antimycin A and funiculosin, ascochlorin induced in H. anomala the expression of nuclear-encoded alternative oxidase gene much more strongly than the Qo site inhibitors tested. On the other hand, it suppressed the reduction of cytochrome b and the generation of superoxide anion in the presence of antimycin A3 in a fashion similar to the Qo site inhibitor myxothiazol. These results suggested that ascochlorin might act at both the Qi and the Qo sites of the fungal cytochrome bc1 complex. Indeed, the altered electron paramagnetic resonance (EPR) line shape of the Rieske iron-sulfur protein, and the light-induced time resolved cytochrome b and c reduction kinetics of Rhodobacter capsulatus cytochrome bc1 complex in the presence of ascochlorin demonstrated that this inhibitor can bind to both the Qo and Qi sites of the bacterial enzyme. Additional experiments using purified bovine cytochrome bc1 complex showed that ascochlorin inhibits reduction of cytochrome b by ubiquinone through both Qi and Qo sites. Moreover, crystal structure of chicken cytochrome bc1 complex treated with excess ascochlorin revealed clear electron densities that could be attributed to ascochlorin bound at both the Qi and Qo sites. Overall findings clearly show that ascochlorin is an unusual

  15. Cap Snatching in Yeast L-BC Double-stranded RNA Totivirus*

    PubMed Central

    Fujimura, Tsutomu; Esteban, Rosa

    2013-01-01

    Yeast L-A double-stranded RNA virus furnishes its transcript with a 5′ cap structure by a novel cap-snatching mechanism in which m7Gp from a host mRNA cap structure is transferred to the 5′-diphosphate terminus of the viral transcript. His-154 of the coat protein Gag forms an m7Gp adduct, and the H154R mutation abolishes both m7Gp adduct formation and cap snatching. Here we show that L-BC, another totivirus closely related to L-A, also synthesizes 5′-diphosphorylated transcripts and transfers m7Gp from mRNA to the 5′ termini of the transcripts. L-BC Gag also covalently binds to the cap structure and the mutation H156R, which corresponds to H154R of L-A Gag, abolishes cap adduct formation. Cap snatching of the L-BC virus is very similar to that of L-A; N7 methylation of the mRNA cap is essential for cap donor activity, and only 5′-diphosphorylated RNA is used as cap acceptor. L-BC cap snatching is also activated by viral transcription. Furthermore, both viruses require Mg2+ and Mn2+ for cap snatching. These cations are not only required for transcription activation but also directly involved in the cap transfer process. These findings support our previous proposal that the cap-snatching mechanism of the L-A virus is shared by fungal totiviruses closely related to L-A. Interestingly, L-A and L-BC viruses accept either viral transcript as cap acceptor in vitro. Because L-A and L-BC viruses cohabit in many yeast strains, it raises the possibility that their cohabitation in the same host may be beneficial for their mutual cap acquisition. PMID:23824187

  16. Cap snatching in yeast L-BC double-stranded RNA totivirus.

    PubMed

    Fujimura, Tsutomu; Esteban, Rosa

    2013-08-16

    Yeast L-A double-stranded RNA virus furnishes its transcript with a 5' cap structure by a novel cap-snatching mechanism in which m(7)Gp from a host mRNA cap structure is transferred to the 5'-diphosphate terminus of the viral transcript. His-154 of the coat protein Gag forms an m(7)Gp adduct, and the H154R mutation abolishes both m(7)Gp adduct formation and cap snatching. Here we show that L-BC, another totivirus closely related to L-A, also synthesizes 5'-diphosphorylated transcripts and transfers m(7)Gp from mRNA to the 5' termini of the transcripts. L-BC Gag also covalently binds to the cap structure and the mutation H156R, which corresponds to H154R of L-A Gag, abolishes cap adduct formation. Cap snatching of the L-BC virus is very similar to that of L-A; N7 methylation of the mRNA cap is essential for cap donor activity, and only 5'-diphosphorylated RNA is used as cap acceptor. L-BC cap snatching is also activated by viral transcription. Furthermore, both viruses require Mg(2+) and Mn(2+) for cap snatching. These cations are not only required for transcription activation but also directly involved in the cap transfer process. These findings support our previous proposal that the cap-snatching mechanism of the L-A virus is shared by fungal totiviruses closely related to L-A. Interestingly, L-A and L-BC viruses accept either viral transcript as cap acceptor in vitro. Because L-A and L-BC viruses cohabit in many yeast strains, it raises the possibility that their cohabitation in the same host may be beneficial for their mutual cap acquisition. PMID:23824187

  17. The structure of the avian mitochondrial cytochrome bc(sub 1) complex

    SciTech Connect

    Berry, Edward A.; Huang, Li-Shar; Zhang, Zhaolei; Kim, Sung-Hou

    1999-05-12

    There are now four structures of vertebrate mitochondrial bc1 complexes available in the protein databases, and structures from yeast and bacterial sources are expected soon. This review summarizes the new information with emphasis on the avian cytochrome bc1 complex (PDB entries 1BCC and 3BCC). The Rieske ironsulfur protein is mobile, and this has been proposed to be important for catalysis. The binding sites for quinone have been located based on structures containing inhibitors and, in the case of the quinone reduction site Qi, the quinone itself.

  18. A century of antenna development

    NASA Astrophysics Data System (ADS)

    Olver, A. D.

    The paper describes a century of antenna development as part of a century of radio communications. This historical review examines, chronologically, the pre-Hertz period, Hertz antennas, the microwave optics period, the Marconi era, short waves, theoretical design before and after computers, and radar. Consideration is also given to mobile antennas, microwave comunications, radio astronomy, and satellite comunications.

  19. 21st Century Skills Map

    ERIC Educational Resources Information Center

    Partnership for 21st Century Skills, 2011

    2011-01-01

    The Partnership for 21st Century Skills (P21) has forged alliances with key national organizations representing the core academic subjects, including Social Studies, English, Math, Science, Geography, World Languages and the Arts. These collaborations have resulted in the development of 21st Century Skills Maps that illustrate the essential…

  20. Fueling the 21st century

    SciTech Connect

    Sheindlin, A.E. ); Zaleski, P. )

    1989-01-01

    This book discusses fueling of the 21st century. Topics include: Basic World Energy Problems at the Turn of the 21st Century, Natural Gas at the Present Stage of Development of Power Engineering, and Biomass-Powered Ice- Making Machine.

  1. The Cosmic Century

    NASA Astrophysics Data System (ADS)

    Longair, Malcolm S.

    2013-04-01

    Part I. Stars and Stellar Evolution up to the Second World War: 1. The legacy of the nineteenth century; 2. The classification of stellar spectra; 3. Stellar structure and evolution; 4. The end points of stellar evolution; Part II. The Large-Scale Structure of the Universe, 1900-1939: 5. The Galaxy and the nature of spiral nebulae; 6. The origins of astrophysical cosmology; Part III. The Opening up of the Electromagnetic Spectrum: 7. The opening up of the electromagnetic spectrum and the new astronomies; Part IV. The Astrophysics of Stars and Galaxies since 1945: 8. Stars and stellar evolution; 9. The physics of the interstellar medium; 10. The physics of galaxies and clusters of galaxies; 11. High-energy astrophysics; Part V. Astrophysical Cosmology since 1945: 12. Astrophysical cosmology; 13. The determination of cosmological parameters; 14. The evolution of galaxies and active galaxies with cosmic epoch; 15. The origin of galaxies and the large-scale structure of the Universe; 16. The very early Universe; References; Name index; Object index; Subject index.

  2. The Cosmic Century

    NASA Astrophysics Data System (ADS)

    Longair, Malcolm S.

    2006-06-01

    Part I. Stars and Stellar Evolution up to the Second World War: 1. The legacy of the nineteenth century; 2. The classification of stellar spectra; 3. Stellar structure and evolution; 4. The end points of stellar evolution; Part II. The Large-Scale Structure of the Universe, 1900-1939: 5. The Galaxy and the nature of spiral nebulae; 6. The origins of astrophysical cosmology; Part III. The Opening up of the Electromagnetic Spectrum: 7. The opening up of the electromagnetic spectrum and the new astronomies; Part IV. The Astrophysics of Stars and Galaxies since 1945: 8. Stars and stellar evolution; 9. The physics of the interstellar medium; 10. The physics of galaxies and clusters of galaxies; 11. High-energy astrophysics; Part V. Astrophysical Cosmology since 1945: 12. Astrophysical cosmology; 13. The determination of cosmological parameters; 14. The evolution of galaxies and active galaxies with cosmic epoch; 15. The origin of galaxies and the large-scale structure of the Universe; 16. The very early Universe; References; Name index; Object index; Subject index.

  3. Black Carbon Aging from SOA Coatings and Coagulation with Diesel BC Emissions during SAAS at the PNNL Environmental Chamber

    NASA Astrophysics Data System (ADS)

    Aiken, A. C.; Liu, S.; Dubey, M. K.; Zaveri, R. A.; Shilling, J. E.; Gourihar, K.; Pekour, M. S.; Subramanian, R.; Zelenyuk, A.; Wilson, J. M.; Mazzoleni, C.; China, S.; Sharma, N.

    2014-12-01

    Black carbon (BC) is considered to be potentially the 2nd most important global warming factor behind CO2 (Bond et al., 2013). Uncertainties exist due to BC morphology and mixing state on the extent of the warming that it causes, e.g. Cappa et al., 2012. Core-shell BC is expected to enhance absorption by up to a factor of 2, but has yet to be observed to this extent from ambient data. Experiments were conducted during the Soot Aerosol Aging Study (SAAS) Laboratory Campaign at Pactific Northwest National Laboratory's Environmental Chamber in the winter of 2013-2014 to investigate the relationship between coatings and enhancements from diesel emissions. Direct on-line measurements were made with the single particle soot photometer (SP2) from fresh and aged BC from coating and coagulation experiments with secondary organic aerosol (SOA) formed in the chamber. BC measurements are coupled with photoactoustic measurements spanning the visible region to probe BC enhancements when mixed with SOA. Here we focus on the enhancements at 781 nm, that are tracked throughout SOA growth on BC, as determined from SP2 coating thicknesses. Thermal denuder (TD) experiments are conducted and enhancements are calculated from two different methods that agree well with each other, confirming the observed results. BC measurements are also compared with co-located measurements from SPLAT-II and filter analysis using SEM and TEM. BC coagulated with SOA produces minimal absorption enhancement values, whereas coatings are observed to have significant enhancement values at 300 degrees C, e.g. 1.3 for thickly coated BC. BC particles were coagulated with SOA in the chamber since this morphology has been observed in wildfire emissions (Sedlacek et al., 2012). Since we did not observe appreciable enhancements for the coagulated BC, we expect that ambient emissions dominated by this particle type to have enhancements due to other sources, such as brown carbon (BrC) that is often co-emitted (Saleh et

  4. The 7th International Cryocooler Conference

    NASA Astrophysics Data System (ADS)

    1993-04-01

    The partial contents of this document include the following: SDIO and Air Force Cryocooler Technology Developments at USAF Phillips Laboratory; JPL Cryocooler Development and Test Program Overview; Development and Demonstration of a Diaphragm Stirling 65 K Standard Spacecraft Cryocooler; Stirling Space Cooler; Thermal, Vibration, and Reliability Test Results for a Balanced 80 K Cryocooler; Spacecraft Cooler Characterization; Performance of a Long Life Reverse Brayton Cryocooler; SDI Cryocooler Producibility Program; Miniature Pulse Tube Cooler; Flow Patterns Intrinsic to the Pulse Tube Refrigerator; Experimental Investigation of the Regenerative Magnetic Refrigerator Operating Between 4.2 K and 1.8 K; A 4 K Gifford-McMahon Refrigerator for Radio Astronomy; A Stirling Cycle Cryocooler for 4 K Applications; Regenerator Performance and Refrigeration Mechanism for 4 K GM Refrigerator Using Rare Earth Compound Regenerator Materials; Superfluid Stirling Refrigerator with a Counterflow Regenerator; Graded and Nongraded Regenerator Performance; Evolution of the 10 K Periodic Sorption Refrigerator Concept; Development of a Periodic 10 K Sorption Cryocooler; Assessment of a Hydrogen Joule-Thomson Expander and Vanadium Hydride Sorption Beds for 20 K Cryocoolers; Design of a Metal Hydride Sorption Cryocooler System; Linear Compressor for JT Cryocooler; JT Cryostat with Liquid-Solid Cryogen Reservoir; Design of A Metal Hydride Sorption Cryocooler System; Linear Compressor for JT Cooler; and Phase Equilibria in Cryogenic Mixtures.

  5. 7(th) International Immunoglobulin Conference: Poster presentations.

    PubMed

    Warnatz, K; Ballow, M; Stangel, M; Bril, V

    2014-12-01

    Immunoglobulin (Ig) therapy is the mainstay of treatment for primary antibody deficiency disorders and has proved to be efficacious in specific autoimmune and inflammatory diseases. Additionally, due to the role of Ig in complement activation, it is being used increasingly in solid organ transplantation. Furthermore, Ig is the primary or secondary treatment in some immune-mediated neuropathies such as chronic inflammatory demyelinating polyneuropathy (CIDP) or multifocal motor neuropathy (MMN). This session discusses trends of Ig use in Europe, proposed mechanisms of action, adverse effects and the potential role of Ig therapy in transplantation. Dr Šedivá reported that Ig therapy is available in all European countries, although dosing is not always optimal, due partly to reimbursement plans. Subcutaneous immunoglobulin (SCIg) has become increasingly accessible in recent years; however, the chosen route of administration still varies widely between countries. Dr Berger's presentation on optimization of Ig therapy in neuropathies, and Dr Rojavin's report on a pharmacometric model to determine the serum IgG levels achieved by different dosing regimens in primary antibody deficiency (PAD) patients, led to the challenging concept of using individualized dosing strategies. Dr Klehmet reported on the potential benefit of using antigen-specific T cell responses as a biomarker of IVIg responsiveness in CIDP patients, while Dr von Gunten provided an insight into the mechanisms of action of Ig preparations, suggesting that the immunoregulatory effects of IgG may be mediated by IgG antibodies against glycans. Dr Basta reported on the potential thrombogenic adverse effects associated with Ig therapy. Although these adverse events are rare, further studies are needed to clarify the relationship between Ig replacement and immunomodulatory therapy and these adverse reactions. In transplantation, Dr Carbone described that prophylactic IVIg treatment was found to decrease the incidence of severe infection in IgG hypogammaglobulinaemia patients undergoing heart transplantations. Furthermore, Dr Clatworthy reported that inactivating polymorphisms in the inhibitory receptor FcγRIIB do not impact upon kidney allograft survival. PMID:25546796

  6. 7th International Immunoglobulin Conference: Immunomodulation

    PubMed Central

    Danieli, M G; Shoenfeld, Y

    2014-01-01

    Immunomodulation uses synthetic, natural and recombinant preparations to modify the immune response to a desired level, typically to treat specific autoimmune diseases, as will be discussed in this section. Rheumatoid arthritis (RA) is a common systemic autoimmune disease, affecting 1% of the population worldwide. Currently, a first-line disease-modifying therapy for RA is methotrexate; however, more than 40 monoclonal antibodies are in use or under investigation for the treatment of RA. This panoply of biological disease-modifying agents means that clinicians can make use of drugs with different mechanisms of action should one type become ineffective. In autoimmune pemphigus conditions, identification of pathogenic autoantibodies against intercellular cadherin desmoglein 1 and/or 3 antigens is one of the criteria for appropriate diagnosis. In pemphigoid conditions, autoantibodies are directed against bullous pemphigoid antigens BP230 and BP180, and in both types of immunobullous disease intravenous immunoglobulin (IVIg), as adjuvant therapy in combination with a cytotoxic drug, is effective in reducing autoantibody levels, disease severity and background steroid use. Further studies are required to establish the role of monoclonal antibodies in the treatment of autoimmune bullous disease. IVIg may also be effective in another at-risk population with autoimmune disease, namely secondary recurrent miscarriage (RM). However, the mechanism of action of IVIg in secondary RM is largely unknown, although levels of natural killer cell biomarkers, particularly CD56+, have been shown to decline after IVIg treatment [1-6]. Data from meta-analyses of heterogeneous placebo-controlled trials indicate that IVIg may be effective in secondary RM, but most trials to date have used immunomodulatory doses lower than those considered to be efficient in autoimmune disease. The results of a recently completed study may help to address this question. PMID:25546784

  7. 7th International Immunoglobulin Conference: Immunomodulation

    PubMed Central

    Danieli, M G; Shoenfeld, Y

    2014-01-01

    Rheumatoid arthritis (RA) is a debilitating autoimmune disease that is usually treated aggressively to slow the rate of joint destruction. The therapeutic strategy used at the French centre, described here, is to use the non-biological disease-modifying drug, methotrexate, as first-line therapy and to add biological agents as second-line treatment. The two other autoimmune diseases discussed in this session were immunobullous skin diseases, and secondary recurrent miscarriage (RM). In the former conditions, low levels of pathogenic autoantibodies can be achieved with adjuvant intravenous immunoglobulin (IVIg) therapy, usually in combination with an immunosuppressant. Secondary RM has an autoimmune basis, as shown by high tumour necrosis factor (TNF)-α levels and specific human leucocyte antigen (HLA) polymorphisms. Although the mechanism is not yet known, IVIg may also be an effective treatment, despite the generally low doses used in published studies. PMID:25546788

  8. 7th International Immunoglobulin Conference: Immunomodulation.

    PubMed

    Danieli, M G; Shoenfeld, Y

    2014-12-01

    Rheumatoid arthritis (RA) is a debilitating autoimmune disease that is usually treated aggressively to slow the rate of joint destruction. The therapeutic strategy used at the French centre, described here, is to use the non-biological disease-modifying drug, methotrexate, as first-line therapy and to add biological agents as second-line treatment. The two other autoimmune diseases discussed in this session were immunobullous skin diseases, and secondary recurrent miscarriage (RM). In the former conditions, low levels of pathogenic autoantibodies can be achieved with adjuvant intravenous immunoglobulin (IVIg) therapy, usually in combination with an immunosuppressant. Secondary RM has an autoimmune basis, as shown by high tumour necrosis factor (TNF)-α levels and specific human leucocyte antigen (HLA) polymorphisms. Although the mechanism is not yet known, IVIg may also be an effective treatment, despite the generally low doses used in published studies. PMID:25546788

  9. 7th International Immunoglobulin Conference: Immunomodulation.

    PubMed

    Danieli, M G; Shoenfeld, Y

    2014-12-01

    Immunomodulation uses synthetic, natural and recombinant preparations to modify the immune response to a desired level, typically to treat specific autoimmune diseases, as will be discussed in this section. Rheumatoid arthritis (RA) is a common systemic autoimmune disease, affecting 1% of the population worldwide. Currently, a first-line disease-modifying therapy for RA is methotrexate; however, more than 40 monoclonal antibodies are in use or under investigation for the treatment of RA. This panoply of biological disease-modifying agents means that clinicians can make use of drugs with different mechanisms of action should one type become ineffective. In autoimmune pemphigus conditions, identification of pathogenic autoantibodies against intercellular cadherin desmoglein 1 and/or 3 antigens is one of the criteria for appropriate diagnosis. In pemphigoid conditions, autoantibodies are directed against bullous pemphigoid antigens BP230 and BP180, and in both types of immunobullous disease intravenous immunoglobulin (IVIg), as adjuvant therapy in combination with a cytotoxic drug, is effective in reducing autoantibody levels, disease severity and background steroid use. Further studies are required to establish the role of monoclonal antibodies in the treatment of autoimmune bullous disease. IVIg may also be effective in another at-risk population with autoimmune disease, namely secondary recurrent miscarriage (RM). However, the mechanism of action of IVIg in secondary RM is largely unknown, although levels of natural killer cell biomarkers, particularly CD56(+) , have been shown to decline after IVIg treatment. Data from meta-analyses of heterogeneous placebo-controlled trials indicate that IVIg may be effective in secondary RM, but most trials to date have used immunomodulatory doses lower than those considered to be efficient in autoimmune disease. The results of a recently completed study may help to address this question. PMID:25546784

  10. 7th International Immunoglobulin Conference: Immunodeficiencies.

    PubMed

    Schmidt, R E; Ochs, H D

    2014-12-01

    Most primary immunodeficiency disorders (PID) are the result of single gene defects. Based on this fact, more than 240 different entities have been identified. Those PIDs with predominant antibody deficiency are treated with immunoglobulin (Ig) replacement therapy. This review focuses on the diagnosis, clinical characteristics and treatment of patients suffering from PID, or secondary immunodeficiency disorders (SID) caused, for instance, by irradiation, immunosuppressive drugs or thymectomy. Common variable immunodeficiency (CVID) is the most commonly diagnosed and least understood form of PID, with a heterogeneous range of symptoms and genotypes, requiring individualized treatment plans. This includes adjusting the dose and treatment interval, administrating Ig by intravenous or subcutaneous injection by either pump or push, and finally deciding which treatment options are best for a given patient. Ig therapy can also be used to treat immunodeficiencies resulting from lymphoproliferative and autoimmune diseases or immunosuppression following organ transplantation; however, there is an urgent need for research in this field. Accurate and early diagnosis of PID is important to ensure that optimal treatment is started early to maintain the patient's health. Detailed patient registries have been established to increase awareness of PID, as well as provide a valuable resource for further research. PMID:25546741

  11. NRP 7th Edition: Are You Prepared?

    PubMed

    Zaichkin, Jeanette; Mccarney, Linda; Weiner, Gary

    2016-01-01

    The seventh edition of the American Academy of Pediatrics/American Heart Association Neonatal Resuscitation Program (NRP) materials must be in use by January 1, 2017. As in previous editions, changes in resuscitation science are based on an international review and consensus of current resuscitation science. The seventh edition NRP materials also include enhancements to training materials aimed at improving the quality of NRP instruction and providing the opportunity for ongoing education. A standardized approach to instructor training, an online Instructor Toolkit, eSim cases, and a new learning management system are among the new resources. PMID:27461196

  12. Credit Transfer: Models and Systems in BC, North America and beyond. Special Report

    ERIC Educational Resources Information Center

    Finlay, Finola

    2009-01-01

    Many jurisdictions have implemented new models of transfer, building on the bedrock of course-to-course articulation, in attempts to address mobility issues and ease transfer for students. The British Columbia (BC) postsecondary system has in the past considered proposals for new models of transfer. System-wide consultations have resulted in the…

  13. IQs Predict Differences in the Technological Development of Nations from 1000 BC through 2000 AD

    ERIC Educational Resources Information Center

    Lynn, Richard

    2012-01-01

    National IQs and measures of technological development given by Comin, Easterly and Gong (2010) are presented for 133 nations for the year 1000 BC, for 134 nations for 0 AD, for 120 nations for 1500 AD and for 133 nations for 2000 AD. It is shown that national IQs are significantly correlated with national differences in technological development…

  14. Research Results: Mobility of BC Transfer Students. Fall 2007 to Calendar Year 2008

    ERIC Educational Resources Information Center

    Heslop, Joanne

    2009-01-01

    This newsletter highlights research results on the Mobility of Transfer Students (MTS), a branch of research conducted under the auspices of the Student Transitions Project (STP). In this annual study, students enrolled in the Fall of 2007 in BC colleges, university colleges, and institutes were followed into calendar year 2008 to identify those…

  15. 47 CFR 52.12 - North American Numbering Plan Administrator and B&C Agent.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 3 2012-10-01 2012-10-01 false North American Numbering Plan Administrator and...) COMMON CARRIER SERVICES (CONTINUED) NUMBERING Administration § 52.12 North American Numbering Plan Administrator and B&C Agent. The North American Numbering Plan Administrator (“NANPA”) and the associated...

  16. BC International Student Revenue Grows Again. BCTF Research Report. Section V. 2012-EF-02

    ERIC Educational Resources Information Center

    Kuehn, Larry

    2011-01-01

    After two years of decline, the tuition from international students increased in 2010-11 and reached more than $129 million. The revenue from international students has more than doubled in a decade, from $55.5 million in 2001-02. This revenue is the most significant source of funding for K-12 education in BC outside of direct grants from the…

  17. Immediate and Delayed Transitions from Secondary School Graduation to Public Post-Secondary Education in BC

    ERIC Educational Resources Information Center

    British Columbia Ministry of Education, 2006

    2006-01-01

    In the spring of 2005, the Ministry of Advanced Education on behalf of the 22 Central Data Warehouse (CDW) participating institutions, the Ministry of Education, and the BC Universities signed an agreement to establish a formal mechanism that protects individual privacy while enabling the exchange of personal information between the parties for…

  18. English Proficiency Requirements at BC Post-Secondary Institutions: Challenges Posed for Students. Research Results

    ERIC Educational Resources Information Center

    Cooke, Jim

    2011-01-01

    This newsletter presents key observations from a review of BC post-secondary institutional websites undertaken to assess any differences in admission requirements for entry into standard First Year English courses and in institutional English admission requirements. Recommendations are made on possible actions that could be taken to clarify…

  19. The Comet Of 44 B.C. and Caesar's Funeral Games

    NASA Astrophysics Data System (ADS)

    Ramsey, John T.; Licht, A. Lewis

    1997-05-01

    Using insights from physics and classics, this book explores the social and cultural implications of the spectacular, daylight comet that was observed in 44 B.C. during the games that the future emperor Augustus gave in honor of the late Julius Caesar.

  20. The inducible elongin A elongation activation domain: structure, function and interaction with the elongin BC complex.

    PubMed Central

    Aso, T; Haque, D; Barstead, R J; Conaway, R C; Conaway, J W

    1996-01-01

    The elongin (SIII) complex strongly stimulates the rate of elongation by RNA polymerase II by suppressing transient pausing by polymerase at many sites along the DNA. Elongin (SIII) is composed of a transcriptionally active A subunit and two small regulatory B and C subunits, which bind stably to each other to form a binary complex that interacts with elongin A and strongly induces its transcriptional activity. The elongin (SIII) complex is a potential target for negative regulation by the von Hippel-Lindau (VHL) tumor suppressor protein, which is capable of binding stably to the elongin BC complex and preventing it from activating elongin A. Here, we identify an elongin A domain sufficient for activation of elongation and demonstrate that it is a novel type of inducible activator that targets the RNA polymerase II elongation complex and is evolutionarily conserved in species as distantly related as Caenorhabditis elegans and man. In addition, we demonstrate that both the elongin A elongation activation domain and the VHL tumor suppressor protein interact with the elongin BC complex through a conserved elongin BC binding site motif that is essential for induction of elongin A activity by elongin BC and for tumor suppression by the VHL protein. Images PMID:8896449

  1. Structural Basis of Resistance to Anti-Cytochrome bc1 Complex Inhibitors: Implication for Drug Improvement

    PubMed Central

    Esser, Lothar; Yu, Chang-An; Xia, Di

    2016-01-01

    The emergence of drug resistance has devastating economic and social consequences, a testimonial of which is the rise and fall of inhibitors against the respiratory component cytochrome bc1 complex, a time tested and highly effective target for disease control. Unfortunately, the mechanism of resistance is a multivariate problem, including primarily mutations in the gene of the cytochrome b subunit but also activation of alternative pathways of ubiquinol oxidation and pharmacokinetic effects. There is a considerable interest in designing new bc1 inhibitors with novel modes of binding and lower propensity to induce the development of resistance. The accumulation of crystallographic data of bc1 complexes with and without inhibitors bound provides the structural basis for rational drug design. In particular, the cytochrome b subunit offers two distinct active sites that can be targeted for inhibition - the quinol oxidation site and the quinone reduction site. This review brings together available structural information of inhibited bc1 by various quinol oxidation- and reduction-site inhibitors, the inhibitor binding modes, conformational changes upon inhibitor binding of side chains in the active site and large scale domain movements of the iron-sulfur protein subunit. Structural data analysis provides a clear understanding of where and why existing inhibitors fail and points towards promising alternatives. PMID:23688079

  2. Synthetic Studies on the Bryostatins: Preparation of a Truncated BC-Ring Intermediate by Pyran Annulation

    PubMed Central

    Keck, Gary E.; Truong, Anh P.

    2006-01-01

    A synthesis of a potential BC-ring subunit (C9–C27) for bryostatin 1, a remarkably potent anticancer agent, has been developed in 16 steps and 18% overall yield. The key features of this route include a BITIP-catalyzed asymmetric allylation reaction, chelation-controlled allylations, a hydroformylation reaction, and a pyran annulation reaction. PMID:15901156

  3. Presenting Computer Literacy for the B.C. Generation at the Smithsonian Institution.

    ERIC Educational Resources Information Center

    Martin, C. Dianne; Heller, Rachelle S.

    1984-01-01

    Though computer literacy has become a key educational issue of the 1980s, little attention has been paid to adults over the age of 25 who received their formal education Before Computers (B.C.). One-day seminars (developed at the request of the Smithsonian Institution) designed to satisfy this need are described. (JN)

  4. Hydrogen peroxide biosensor based on microperoxidase-11 immobilized on flexible MWCNTs-BC nanocomposite film.

    PubMed

    Zhang, Bingyan; Zhou, Jianhai; Li, Shaohui; Zhang, Xiaofan; Huang, Dekang; He, Yahui; Wang, Mingkui; Yang, Guang; Shen, Yan

    2015-01-01

    In the present work, we report on an experimental study of flexible nanocomposite film for electrochemical detection of hydrogen peroxide (H2O2) based on bacterial cellulose (BC) and multi-walled carbon nanotubes (MWCNTs) in combination with microperoxidase-11 (MP-11). MWCNTs are used to functionalize BC and provide a flexible conductive film. On the other hand, BC can improve MWCNTs׳ biocompatibility. The investigation shows that MP-11 immobilized on the flexible film of MWCNTs-BC can easily present a pair of well-defined and quasi-reversible redox peaks, revealing a direct electrochemistry of MP-11 on the nanocomposite film. The apparent heterogeneous electron-transfer rate constant ks is estimated to be 11.5s(-1). The resulting flexible electrode presents appreciated catalytic properties for electrochemical detection of H2O2, comparing to traditional electrodes (such as gold, glassy carbon electrode) modified with MP-11. The proposed biosensor exhibits a low detection limit of 0.1 µM (at a signal-to-noise ratio of 3) with a linear range of 0.1-257.6 µM, and acquires a satisfactory stability. PMID:25281099

  5. The BC Provincial Education Number (PEN): Considerations for Assigning the PEN to Post-Secondary Applicants

    ERIC Educational Resources Information Center

    Link, Greg

    2004-01-01

    The BC Council on Admissions and Transfer (BCCAT) has had a long-standing interest in measures of student mobility and the potential of the Provincial Education Number (PEN) being applied in post-secondary institutions at the applicant stage. The Admissions Committee of BCCAT included a project in its 2004/05 Work Plan to conduct a thorough…

  6. When Does Rank(ABC)= Rank(AB) + Rank(BC) - Rank(B) Hold?

    ERIC Educational Resources Information Center

    Tian, Yongge; Styan, George P. H.

    2002-01-01

    The well-known Frobenius rank inequality established by Frobenius in 1911 states that the rank of the product ABC of three matrices satisfies the inequality rank(ABC) [greater than or equal]rank(AB) + rank(BC) - rank(B) A new necessary and sufficient condition for equality to hold is presented and then some interesting consequences and…

  7. Sixteenth Century Astronomical Telescopy

    NASA Astrophysics Data System (ADS)

    Usher, P. D.

    2001-12-01

    Ophelia in Shakespeare's Hamlet is named for the ``moist star" which in mythology is the partner of Hamlet's royal Sun. Together the couple seem destined to rule on earth just as their celestial counterparts rule the heavens, but the tragedy is that they are afflicted, just as the Sun and Moon are blemished. In 1.3 Laertes lectures Ophelia on love and chastity, describing first Cytherean phases (crescent to gibbous) and then Lunar craters. Spots mar the Sun (1.1, 3.1). Also reported are Jupiter's Red Spot (3.4) and the resolution of the Milky Way into stars (2.2). These interpretations are well-founded and support the cosmic allegory. Observations must have been made with optical aid, probably the perspective glass of Leonard Digges, father of Thomas Digges. Notably absent from Hamlet is mention of the Galilean moons, owing perhaps to the narrow field-of-view of the telescope. That discovery is later celebrated in Cymbeline, published soon after Galileo's Siderius Nuncius in 1610. In 5.4 of Cymbeline the four ghosts dance ``in imitation of planetary motions" and at Jupiter's behest place a book on the chest of Posthumus Leonatus. His name identifies the Digges father and son as the source of data in Hamlet since Jupiter's moons were discovered after the deaths of Leonard (``leon+hart") and Thomas (the ``lion's whelp"). Lines in 5.4 urge us not to read more into the book than is contained between its covers; this is understandable because Hamlet had already reported the other data in support of heliocentricism and the cosmic model discussed and depicted by Thomas Digges in 1576. I conclude therefore that astronomical telescopy began in England before the last quarter of the sixteenth century.

  8. Premature deaths attributed to source-specific BC emissions in six urban US regions

    NASA Astrophysics Data System (ADS)

    Turner, Matthew D.; Henze, Daven K.; Capps, Shannon L.; Hakami, Amir; Zhao, Shunliu; Resler, Jaroslav; Carmichael, Gregory R.; Stanier, Charles O.; Baek, Jaemeen; Sandu, Adrian; Russell, Armistead G.; Nenes, Athanasios; Pinder, Rob W.; Napelenok, Sergey L.; Bash, Jesse O.; Percell, Peter B.; Chai, Tianfeng

    2015-11-01

    Recent studies have shown that exposure to particulate black carbon (BC) has significant adverse health effects and may be more detrimental to human health than exposure to PM2.5 as a whole. Mobile source BC emission controls, mostly on diesel-burning vehicles, have successfully decreased mobile source BC emissions to less than half of what they were 30 years ago. Quantification of the benefits of previous emissions controls conveys the value of these regulatory actions and provides a method by which future control alternatives could be evaluated. In this study we use the adjoint of the Community Multiscale Air Quality (CMAQ) model to estimate highly-resolved spatial distributions of benefits related to emission reductions for six urban regions within the continental US. Emissions from outside each of the six chosen regions account for between 7% and 27% of the premature deaths attributed to exposure to BC within the region. While we estimate that nonroad mobile and onroad diesel emissions account for the largest number of premature deaths attributable to exposure to BC, onroad gasoline is shown to have more than double the benefit per unit emission relative to that of nonroad mobile and onroad diesel. Within the region encompassing New York City and Philadelphia, reductions in emissions from large industrial combustion sources that are not classified as EGUs (i.e., non-EGU) are estimated to have up to triple the benefits per unit emission relative to reductions to onroad diesel sectors, and provide similar benefits per unit emission to that of onroad gasoline emissions in the region. While onroad mobile emissions have been decreasing in the past 30 years and a majority of vehicle emission controls that regulate PM focus on diesel emissions, our analysis shows the most efficient target for stricter controls is actually onroad gasoline emissions.

  9. Ancient Skeletal Evidence for Leprosy in India (2000 B.C.)

    PubMed Central

    Robbins, Gwen; Tripathy, V. Mushrif; Misra, V. N.; Mohanty, R. K.; Shinde, V. S.; Gray, Kelsey M.; Schug, Malcolm D.

    2009-01-01

    Background Leprosy is a chronic infectious disease caused by Mycobacterium leprae that affects almost 250,000 people worldwide. The timing of first infection, geographic origin, and pattern of transmission of the disease are still under investigation. Comparative genomics research has suggested M. leprae evolved either in East Africa or South Asia during the Late Pleistocene before spreading to Europe and the rest of the World. The earliest widely accepted evidence for leprosy is in Asian texts dated to 600 B.C. Methodology/Principal Findings We report an analysis of pathological conditions in skeletal remains from the second millennium B.C. in India. A middle aged adult male skeleton demonstrates pathological changes in the rhinomaxillary region, degenerative joint disease, infectious involvement of the tibia (periostitis), and injury to the peripheral skeleton. The presence and patterning of lesions was subject to a process of differential diagnosis for leprosy including treponemal disease, leishmaniasis, tuberculosis, osteomyelitis, and non-specific infection. Conclusions/Significance Results indicate that lepromatous leprosy was present in India by 2000 B.C. This evidence represents the oldest documented skeletal evidence for the disease. Our results indicate that Vedic burial traditions in cases of leprosy were present in northwest India prior to the first millennium B.C. Our results also support translations of early Vedic scriptures as the first textual reference to leprosy. The presence of leprosy in skeletal material dated to the post-urban phase of the Indus Age suggests that if M. leprae evolved in Africa, the disease migrated to India before the Late Holocene, possibly during the third millennium B.C. at a time when there was substantial interaction among the Indus Civilization, Mesopotamia, and Egypt. This evidence should be impetus to look for additional skeletal and molecular evidence of leprosy in India and Africa to confirm the African origin of

  10. Link between local scale BC emissions and large scale atmospheric solar absorption

    NASA Astrophysics Data System (ADS)

    Praveen, P. S.; Ahmed, T.; Kar, A.; Rehman, I. H.; Ramanathan, V.

    2011-07-01

    Project Surya has documented indoor and outdoor concentrations of black carbon (BC) from traditional biomass burning cook stoves in a rural village located in the Indo-Gangetic Plains (IGP) region of N. India from November 2009- September 2010. In this paper, we systematically document the link between local scale aerosol properties and column averaged regional aerosol optical properties and atmospheric radiative forcing. We report observations from the first phase of Project Surya to estimate the source dependent (biomass and fossil fuels) aerosol optical properties from local to regional scale. Data were collected using surface based observations of BC, organic carbon (OC), aerosol light absorption, scattering coefficient at the Surya village (SVI_1) located in IGP region, and satellite and AERONET observations at the regional scale (IGP). The daily mean BC concentrations at SVI1 showed the large increase of BC during the dry season (December to February) with values reaching 35 μg m-3. Space based LIDAR data reveal how the biomass smoke is trapped within the first kilometre during the dry season and its extension to above 5 km during the pre-monsoon season. As a result during the dry season, the variance in the daily mean SSA and column aerosol optical properties at the local IGP site correlated (with slopes in the range of 0.85 to 1.06 and R2>0.4) well with the "IGP_AERONET" (mean of six AERONET sites), thus suggesting in-situ observations at few locations can be used to infer spatial mean forcing. The atmospheric forcing due to BC and OC exceeded 20 W m-2 during all months from November to May, leading to the deduction that elimination of cook stove smoke emissions through clean cooking technologies will likely have a major positive impact on health and the regional climate.

  11. Identification of a new HIV-1 BC circulating recombinant form (CRF60_BC) in Italian young men having sex with men.

    PubMed

    Simonetti, Francesco Roberto; Lai, Alessia; Monno, Laura; Binda, Francesca; Brindicci, Gaetano; Punzi, Grazia; Bozzi, Giorgio; Violin, Michela; Galli, Massimo; Zazzi, Maurizio; Angarano, Gioacchino; Balotta, Claudia

    2014-04-01

    HIV-1 recombination, reverse transcriptase (RT) low fidelity and high replication rate are the drivers of variability and evolution on the global scale. Only few of these HIV-1 chimeric forms have been characterized in Europe, despite 20% of infections are due to unique or circulating recombinant forms worldwide. An outbreak of BC recombinants has been recently described in a southern region of Italy, Apulia, in men having sex with men (MSM) seeking sexual partners on-line. We analyzed the full length genome of HIV-1 BC recombinants harbored by three recently infected subjects, two MSM and a heterosexual woman, with no evidence of epidemiological link. The recombination analysis showed a unique recombination pattern of a subtype C genome with 3 subtype B fragments corresponding to HXB2 positions: [1-463] in the 5'LTR , [2804-3037] in RT and [8662-9548] corresponding to the C-terminal segment of gp41, nef and most of 3'LTR. Phylogenetic analysis revealed the South American origin of the C subtype parental strain. A research conducted in an Italian nationwide database provided six additional similar sequences from other Italian regions with identical recombination pattern in pol gene; a further BLAST search retrieved one full length genome isolated in France with the same mosaic pattern, except an additional B subtype short fragment in the integrase region. These recombinant isolates, designated CRF60_BC, led to the identification of the first Italian circulating recombinant form, which gave rise to an epidemic burst mainly involving MSM. PMID:24602697

  12. Profile of BC College Transfer Students Admitted to Simon Fraser University 2003/04 to 2007/08

    ERIC Educational Resources Information Center

    Lee, Jacy; Chan, Liny; Chuang, Rachel

    2009-01-01

    This report presents data and analysis about students admitted to Simon Fraser University (SFU) who have BC College experience in the period 2003/04 to 2007/08. The first and second sections of the report focus on the profile of students admitted to SFU on the basis of BC College transfer including number of credits transferred, institution…

  13. Movement of All Registrants among B.C. Public Post-Secondary Institutions. Research Results from the Student Transitions Project

    ERIC Educational Resources Information Center

    Ministry of Advanced Education and Labour Market Development, 2009

    2009-01-01

    In this study, the Student Transitions Project (STP) examined the movement of all British Columbia (BC) pubic post-secondary registrants between post-secondary institutions from 2003/03 to the Fall of 2007. This is an expansion of STP's previous research focusing on the movement and outcomes of a cohort of BC secondary school graduates. (Contains…

  14. Studies on Inhibition of Respiratory Cytochrome bc1 Complex by the Fungicide Pyrimorph Suggest a Novel Inhibitory Mechanism

    PubMed Central

    Xiao, Yu-Mei; Esser, Lothar; Zhou, Fei; Li, Chang; Zhou, Yi-Hui; Yu, Chang-An; Qin, Zhao-Hai; Xia, Di

    2014-01-01

    The respiratory chain cytochrome bc1 complex (cyt bc1) is a major target of numerous antibiotics and fungicides. All cyt bc1 inhibitors act on either the ubiquinol oxidation (QP) or ubiquinone reduction (QN) site. The primary cause of resistance to bc1 inhibitors is target site mutations, creating a need for novel agents that act on alternative sites within the cyt bc1 to overcome resistance. Pyrimorph, a synthetic fungicide, inhibits the growth of a broad range of plant pathogenic fungi, though little is known concerning its mechanism of action. In this study, using isolated mitochondria from pathogenic fungus Phytophthora capsici, we show that pyrimorph blocks mitochondrial electron transport by affecting the function of cyt bc1. Indeed, pyrimorph inhibits the activities of both purified 11-subunit mitochondrial and 4-subunit bacterial bc1 with IC50 values of 85.0 μM and 69.2 μM, respectively, indicating that it targets the essential subunits of cyt bc1 complexes. Using an array of biochemical and spectral methods, we show that pyrimorph acts on an area near the QP site and falls into the category of a mixed-type, noncompetitive inhibitor with respect to the substrate ubiquinol. In silico molecular docking of pyrimorph to cyt b from mammalian and bacterial sources also suggests that pyrimorph binds in the vicinity of the quinol oxidation site. PMID:24699450

  15. 2008 Key Student Outcomes Indicators for BC Diploma, Associate Degree, and Certificate Programs: Survey Results by Institution

    ERIC Educational Resources Information Center

    Ministry of Advanced Education and Labour Market Development, 2009

    2009-01-01

    The BC Diploma, Associate Degree, and Certificate Student Outcomes (DACSO) Survey (formerly the BC College and Institute Student Outcomes Survey) collects and disseminates information about former students' post-secondary experiences and their subsequent labour market and further education experiences. The survey is administered annually to former…

  16. BC4707 Is a Major Facilitator Superfamily Multidrug Resistance Transport Protein from Bacillus cereus Implicated in Fluoroquinolone Tolerance

    PubMed Central

    Simm, Roger; Vörös, Aniko; Ekman, Jaakko V.; Sødring, Marianne; Nes, Ingerid; Kroeger, Jasmin K.; Saidijam, Massoud; Bettaney, Kim E.; Henderson, Peter J. F.; Salkinoja-Salonen, Mirja; Kolstø, Anne-Brit

    2012-01-01

    Transcriptional profiling highlighted a subset of genes encoding putative multidrug transporters in the pathogen Bacillus cereus that were up-regulated during stress produced by bile salts. One of these multidrug transporters (BC4707) was selected for investigation. Functional characterization of the BC4707 protein in Escherichia coli revealed a role in the energized efflux of xenobiotics. Phenotypic analyses after inactivation of the gene bc4707 in Bacillus cereus ATCC14579 suggested a more specific, but modest role in the efflux of norfloxacin. In addition to this, transcriptional analyses showed that BC4707 is also expressed during growth of B. cereus under non-stressful conditions where it may have a role in the normal physiology of the bacteria. Altogether, the results indicate that bc4707, which is part of the core genome of the B. cereus group of bacteria, encodes a multidrug resistance efflux protein that is likely involved in maintaining intracellular homeostasis during growth of the bacteria. PMID:22615800

  17. BC200 LncRNA a potential predictive marker of poor prognosis in esophageal squamous cell carcinoma patients

    PubMed Central

    Zhao, Rui-Hua; Zhu, Cai-hua; Li, Xiang-Ke; Cao, Wei; Zong, Hong; Cao, Xin-Guang; Hu, Hai-Yan

    2016-01-01

    Objective To explore the expression and prognosis significance of BC200 in esophageal squamous cell carcinoma (ESCC) patients who received radical resection. Methods We used quantitative real-time polymerase chain reaction to detect the expression level of BC200 in cancer tissue and paired adjacent normal tissue samples from 70 ESCC patients who received radical surgical resection and analyzed the correlation of the relative expression level of BC200 with clinical-pathological features and prognosis. Results We found that the relative expression of BC200 was significantly higher in ESCC tissues compared with adjacent normal tissue samples (P=0.023). But the expression of BC200 were not related to clinical-pathological features, such as age, TNM stages, and histological grade (P>0.05). Kaplan–Meier analysis showed that high expression levels of BC200 were correlated with poor prognosis in ESCC patients. Patients with a high level of BC200 had a shorter disease-free survival and overall survival than those with low BC200 expression (P=0.034 and P=0.031, respectively). On multivariate analysis, the hazard ratio (HR) of BC200 expression was 2.17 (95% confidence interval [CI]=1.12–4.19, P=0.022) for disease-free survival and 2.24 (95% CI=1.12–4.49, P=0.023) for overall survival. Conclusion Our results indicate that high expression of BC200 reflects poor prognosis and could serve as a novel predictive marker for ESCC patients who received radical resection. PMID:27143917

  18. Remedial investigation/feasibility study work plan for the 100-BC-2 operable unit, Hanford Site, Richland, Washington

    SciTech Connect

    Not Available

    1993-05-01

    This work plan and attached supporting project plans establish the operable unit setting and the objectives, procedures, tasks, and schedule for conducting the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) remedial investigation/feasibility study (RI/FS) for the 100-BC-2 operable unit in the 100 Area of the Hanford Site. The 100 Area is one of four areas at the Hanford Site that are on the US Environmental Protection Agency`s (EPA) National Priorities List under CERCLA. The 100-BC-2 operable unit is one of two source operable units in the 100-B/C Area (Figure ES-1). Source operable units are those that contain facilities and unplanned release sites that are potential sources of hazardous substance contamination. The 100-BC-2 source operable unit contains waste sites that were formerly in the 100-BC-2, 100-BC-3, and 100-BC-4 operable units. Because of their size and geographic location, the waste sites from these two operable units were added to 100-BC-2. This allows for a more efficient and effective investigation of the remaining 100-B/C Reactor area waste sites. The investigative approach to waste sites associated with the 100-BC-2 operable unit are listed in Table ES-1. The waste sites fall into three general categories: high priority liquid waste disposal sites, low priority liquid waste disposal sites, and solid waste burial grounds. Several sites have been identified as candidates for conducting an IRM. Two sites have been identified as warranting additional limited field sampling. The two sites are the 116-C-2A pluto crib, and the 116-C-2C sand filter.

  19. Isolation and characterization of Alicycliphilus denitrificans strain BC, which grows on benzene with chlorate as the electron acceptor.

    PubMed

    Weelink, Sander A B; Tan, Nico C G; ten Broeke, Harm; van den Kieboom, Corné; van Doesburg, Wim; Langenhoff, Alette A M; Gerritse, Jan; Junca, Howard; Stams, Alfons J M

    2008-11-01

    A bacterium, strain BC, was isolated from a benzene-degrading chlorate-reducing enrichment culture. Strain BC degrades benzene in conjunction with chlorate reduction. Cells of strain BC are short rods that are 0.6 microm wide and 1 to 2 microm long, are motile, and stain gram negative. Strain BC grows on benzene and some other aromatic compounds with oxygen or in the absence of oxygen with chlorate as the electron acceptor. Strain BC is a denitrifying bacterium, but it is not able to grow on benzene with nitrate. The closest cultured relative is Alicycliphilus denitrificans type strain K601, a cyclohexanol-degrading nitrate-reducing betaproteobacterium. Chlorate reductase (0.4 U/mg protein) and chlorite dismutase (5.7 U/mg protein) activities in cell extracts of strain BC were determined. Gene sequences encoding a known chlorite dismutase (cld) were not detected in strain BC by using the PCR primers described in previous studies. As physiological and biochemical data indicated that there was oxygenation of benzene during growth with chlorate, a strategy was developed to detect genes encoding monooxygenase and dioxygenase enzymes potentially involved in benzene degradation in strain BC. Using primer sets designed to amplify members of distinct evolutionary branches in the catabolic families involved in benzene biodegradation, two oxygenase genes putatively encoding the enzymes performing the initial successive monooxygenations (BC-BMOa) and the cleavage of catechol (BC-C23O) were detected. Our findings suggest that oxygen formed by dismutation of chlorite can be used to attack organic molecules by means of oxygenases, as exemplified with benzene. Thus, aerobic pathways can be employed under conditions in which no external oxygen is supplied. PMID:18791031

  20. Point defects in hexagonal BN, BC{sub 3} and BC{sub x}N compounds studied by x-ray absorption near-edge structure

    SciTech Connect

    Caretti, Ignacio; Jimenez, Ignacio

    2011-07-15

    The generation of point defects in highly oriented pyrolytic boron nitride (HOPBN) after Ar{sup +} ion bombardment in ultrahigh vacuum and subsequent exposure to air was studied by angle-resolved x-ray absorption near edge structure (XANES). The pristine HOPBN showed well-oriented boron nitride (BN) basal planes parallel to the surface, with a negligible amount of defects. Amorphization of the BN structure took place after Ar{sup +} sputtering, as indicated by the broadening of the XANES spectra and significant decrease of the characteristic {pi}* states. Following air exposure, the XANES analysis revealed a spontaneous reorganization of the sample structure. The appearance of four new B1s {pi}* excitonic peaks indicates an oxygen decoration process of the nitrogen vacancies created by ion bombardment. A core-level shift model is presented to support this statement. This model is successfully extended to the case of oxygen substitutional defects in hexagonal BC{sub 3} and BC{sub x}N (0 < x < 4) materials, which can be applied to any B-based sp{sup 2}-bonded honeycomb structure.

  1. Was the 19th Century end of the Little Ice Age in the Alps forced by industrial black carbon?

    NASA Astrophysics Data System (ADS)

    Painter, T. H.; Flanner, M.; Marzeion, B.; Kaser, G.; VanCuren, R. A.; Abdalati, W.

    2013-12-01

    Glaciers in the European Alps began to retreat abruptly from their mid 19th century maximum, marking what appeared to be the end of the Little Ice Age. Alpine temperature and precipitation records suggest that glaciers should instead have continued to grow until circa 1910. Our current knowledge of the Alpine climate, climatologists consider the climatic end of the LIA to have come markedly later than the glaciological end, resulting in a paradox. Simulations of glacier length variations using glacier flow and mass balance models forced with instrumental and proxy temperature and precipitation fail to match the timing and magnitude of the observed late 19th century retreat. Matches between simulations and observations have only been achieved when additional glacier mass loss is imposed after 1865 or when precipitation signals are generated that would fit the glacier retreat rather than using actual precipitation records. A known transition however did occur across that half century and into the 20th century that may have held powerful potential consequences for absorption of solar radiation, earlier melt of snow cover, and, in turn, the retreat of glaciers. That transition was the dramatic rise in a byproduct of industrialization: black carbon. Ice cores indicate that BC concentrations increased abruptly at mid 19th century and largely continued to increase into the 20th century, consistent with known increases in BC emissions from the industrialization of Western Europe. We estimate the radiative forcings by these changes in BC loading and whether they were of sufficient magnitude to produce the pronounced negative glacier mass balance that began mid 19th century. Inferred annual surface radiative forcings increased stepwise to 13-17 W m-2 between 1850 and 1880, and to 9-22 W m-2 in the early 1900s, with snowmelt season (April/May/June) forcings reaching greater than 35 W m-2 by the early 1900s. These snowmelt season radiative forcings would have resulted in

  2. [The saga of aspirin: centuries-old ancestors of an old lady who doesn't deserve to die].

    PubMed

    Queneau, P

    2001-01-01

    Where do analgics come from? If their ancestors are many centuries old, we observe that the four main drugs of modern analgesia, morphine (1816), codeine (1832), paracetamol (1893) and aspirin (1897) were discovered during the 19th century. And through what 'sagas'! The first known prescriptions, written on earthenware shelves in Mesopotamia 3 centuries BC, already mentioned medications derived from willow to cure headaches. The Greeks dedicated to Asclepios, god of therapeutics, a statue carved in a willow trunk as a symbol! Thus, before becoming a drug, aspirin was born from the willow, which grows with its feet in water 'without suffering', as the ancestors put it. But before it walked on the moon with Neil Armstrong in 1969, the discovery of aspirin as a drug was the consequence of the filial love of a young researcher, Felix Hoffmann, who wanted to decrease the resistant pain of his rheumatic old father. PMID:11878097

  3. New archaeomagnetic data recovered from the study of celtiberic remains from central Spain (Numancia and Ciadueña, III-I BC).

    NASA Astrophysics Data System (ADS)

    Osete, María Luisa; Chauvin, Annick; Catanzariti, Gianluca; Jimeno, Alfredo; Campuzano, Saioa A.; Benito-Batanero, Juan Pedro; Roperch, Pierrick

    2016-04-01

    Variation of geomagnetic field changes in the Iberian Peninsula between prior to roman times remain very poorly constrained. Here we report results from the archeomagnetic study carried out on four set of ceramics and one combustion structure recovered in two pre-roman (celtiberic) archeological sites in central Spain. Rock magnetic experiments indicate the ChRM is carried by magnetite. Archaeointensity determinations were carried out by using the classical Thellier-Thellier experiment including tests and corrections for magnetic anisotropy and magnetic cooling rate dependency. Well heated specimens (red ceramic fragments and well heated samples from the kiln) show one single well defined component of magnetisation going through the origin and a linear arai plot providing successful archaeointensity determinations. The effect of anisotropy of the termoremanent magnetization (ATRM) on paleointensity analysis was specially investigated obtaining very high ATRM corrections on fine pottery specimens. With differences between the uncorrected and ATRM corrected paleointensity values that reached up to 80-100%. Mean intensity values obtained from three selected groups were 61.1 ±5.9μT; 57.6±3.3 and 56.4± 4.7μT which allows delineate the evolution of the paleofield intensity in central Iberia during the III-I centuries BC. The new archaeointensity data disagrees with previous results from Iberian ceramics which were not corrected by the ATRM effect. But they are in agreement with the most recent French paleointensity curve and latest European intensity model. Both based on a selection of high quality paleointensity data. This result reinforces the idea that the puzzling scatter often observed in the global paleointensity database is likely due to differences in the laboratory protocol. Further data from well contrasted laboratory protocols are still necessary to delineate confidently the evolution of the geomagnetic paleofield during the first millennium BC.

  4. Mono-layer BC2 a high capacity anode material for Li-ion batteries

    NASA Astrophysics Data System (ADS)

    Hardikar, Rahul; Samanta, Atanu; Han, Sang Soo; Lee, Kwang-Ryeol; Singh, Abhishek

    2015-04-01

    Mono-layer of graphene with high surface area compared to the bulk graphite phase, shows less Li uptake. The Li activity or kinetics can be modified via defects and/or substitutional doping. Boron and Nitrogen are the best known dopants for carbonaceous anode materials. In particular, boron doped graphene shows higher capacity and better Li adsorption compared to Nitrogen doped graphene. Here, using first principles density functional theory calculations, we study the spectrum of boron carbide (BCx) mono-layer phases in order to estimate the maximum gravimetric capacity that can be achieved by substitutional doping in graphene. Our results show that uniformly boron doped BC2 phase shows a high capacity of? 1400 mAh/g, much higher than previously reported capacity of BC3. Supported by Korea Institute of Science and Technology.

  5. Flow fields within Jupiter's Great Red Spot and White Oval BC

    NASA Technical Reports Server (NTRS)

    Mitchell, J. L.; Garneau, G. W.; Beebe, R. F.; Ingersoll, A. P.

    1981-01-01

    Voyager 1 high-resolution images of Jupiter's Great Red Spot (GRS) and White Oval BC are used to map flow fields within these two areas. The relative vorticity is computed as a function of semi-major axis length and position angle in a coordinate system consisting of concentric ellipses of equal eccentricity. Wind speeds of 110-120 m/s are observed near the outer edge of both features, and along their minor axes relative vorticity profiles reach a maximum of 0.00006/s. Maximum Rossby numbers of 0.36 are computed for flows within both features, and are found to be low, indicating geostrophic constraints on the flow. The difference in streamline curvature within the GRS and the Oval BC is found to compensate for the difference in planetary vorticity at the respective latitudes of the features. Finally, motions within the central region of the GRS are slower and more random than around the spot's outer portion.

  6. High-Pressure and Electronic Band Structure Studies on MoBC

    NASA Astrophysics Data System (ADS)

    Falconi, R.; de la Mora, P.; Morales, F.; Escamilla, R.; Camacho, C. O.; Acosta, M.; Escudero, R.

    2015-05-01

    In this work, high-pressure electrical resistivity measurements and electronic structure analysis on the intermetallic MoBC system are presented. Electrical resistivity measurements up to about 5 GPa using a diamond anvil cell on MoBC revealed that decreases in a non-monotonic way. Using Linearized Augmented Plane Wave method based on Density Functional Theory, we investigate the changes in the electronic structure of this compound as a function of pressure. The states at the Fermi level mainly come from the d orbitals of molybdenum atoms. As the pressure increases, the band width is enhanced and the total density of states at the Fermi level decreases. The Fermi surface for this compound possesses a two-dimensional character which prevails under an applied pressure of about 10 GPa. The results are compared with the chemical pressure effects on induced by the gradual and non-simultaneous elimination of B and C in the compound.

  7. Cytotoxic responses in BC3H1 myoblast cell lines exposed to 1-desulfoyessotoxin.

    PubMed

    Korsnes, Mónica Suárez; Espenes, Arild; Hermansen, Lene C; Loader, Jared I; Miles, Christopher O

    2013-09-01

    1-Desulfoyessotoxin (1-dsYTX) is a desulfated polyether compound belonging to the yessotoxin group of marine toxins. This analogue has been detected in mussels. There are so far no reports on the mechanisms of action of 1-dsYTX in in vitro cell systems. This work evaluates cytotoxic responses in BC3H1 cells exposed to 100 nM 1-dsYTX. The toxicity of 1-dsYTX seems to be similar to that of yessotoxin (YTX). 1-Desulfoyessotoxin induced morphological and biochemical traits typical of a non-apoptotic form of cell death resembling paraptosis. Treated BC3H1 cells showed extensive cytoplasmic vacuolation, enlargement of mitochondria and endoplasmic reticulum and lack of DNA fragmentation. Western blotting analysis revealed phosphorylation of the protein kinase p38 and involvement of the heat shock protein Hsp70. This activation suggests involvement of different signalling pathways for programmed cell death. PMID:23851005

  8. Targeting the Cytochrome bc1 Complex of Leishmania Parasites for Discovery of Novel Drugs.

    PubMed

    Ortiz, Diana; Forquer, Isaac; Boitz, Jan; Soysa, Radika; Elya, Carolyn; Fulwiler, Audrey; Nilsen, Aaron; Polley, Tamsen; Riscoe, Michael K; Ullman, Buddy; Landfear, Scott M

    2016-08-01

    Endochin-like quinolones (ELQs) are potent and specific inhibitors of cytochrome bc1 from Plasmodium falciparum and Toxoplasma gondii and show promise for novel antiparasitic drug development. To determine whether the mitochondrial electron transport chain of Leishmania parasites could be targeted similarly for drug development, we investigated the activity of 134 structurally diverse ELQs. A cohort of ELQs was selectively toxic to amastigotes of Leishmania mexicana and L. donovani, with 50% inhibitory concentrations (IC50s) in the low micromolar range, but the structurally similar hydroxynaphthoquinone buparvaquone was by far the most potent inhibitor of electron transport, ATP production, and intracellular amastigote growth. Cytochrome bc1 is thus a promising target for novel antileishmanial drugs, and further improvements on the buparvaquone scaffold are warranted for development of enhanced therapeutics. PMID:27297476

  9. Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors

    PubMed Central

    Dong, Carolyn; Urgaonkar, Sameer; Cortese, Joseph F.; Gamo, F. Javier; Garcia-Bustos, Jose F.; Lafuente, Maria J.; Patel, Vishal; Ross, Leila; Coleman, Bradley I.; Derbyshire, Emily R.; Clish, Clary B.; Serrano, Adelfa E.; Cromwell, Mandy; Barker, Robert H.; Dvorin, Jeffrey D.; Duraisingh, Manoj T.; Wirth, Dyann F.; Clardy, Jon; Mazitschek, Ralph

    2012-01-01

    Summary Here we report the discovery of tetracyclic benzothiazepines (BTZ) as highly potent and selective antimalarials along with the identification of the Plasmodium falciparum cytochrome bc1 complex as the primary functional target of this novel compound class. Investigation of the structure activity relationship within this previously unexplored chemical scaffold has yielded inhibitors with low nanomolar activity. A combined approach employing genetically modified parasites, biochemical profiling, and resistance selection validated inhibition of cytochrome bc1 activity, an essential component of the parasite respiratory chain and target of the widely used antimalarial drug atovaquone, as the mode of action of this novel compound class. Resistance to atovaquone is eroding the efficacy of this widely used antimalarial drug. Intriguingly, BTZ-based inhibitors retain activity against atovaquone resistant parasites, suggesting this chemical class may provide an alternative to atovaquone in combination therapy. PMID:22195562

  10. BcGs1, a glycoprotein from Botrytis cinerea, elicits defence response and improves disease resistance in host plants.

    PubMed

    Zhang, Yi; Zhang, Yunhua; Qiu, Dewen; Zeng, Hongmei; Guo, Lihua; Yang, Xiufen

    2015-02-20

    In this study, a necrosis-inducing protein was purified from the culture filtrate of the necrotrophic fungus Botrytis cinerea BC-98 strain. Secreted proteins were collected and fractionated by liquid chromatography. The fraction with the highest necrosis-inducing activity was further purified. A glycoprotein named BcGs1 was identified by 2D electrophoresis and mass spectrometry. The BcGs1 protein consisted of 672 amino acids with a theoretical molecular weight of 70.487 kDa. Functional domain analysis indicated that BcGs1 was a glucan 1,4-alpha-glucosidase, a cell wall-degrading enzyme, with a Glyco_hydro_15 domain and a CBM20_glucoamylase domain. The BcGs1 protein caused necrotic lesions that mimicked a typical hypersensitive response and H2O2 production in tomato and tobacco leaves. BcGs1-treated plants exhibited resistance to B. cinerea, Pseudomonas syringae pv. tomato DC3000 and tobacco mosaic virus in systemic leaves. In addition, BcGs1 triggered elevation of the transcript levels of the defence-related genes PR-1a, TPK1b and Prosystemin. This is the first report of a Botrytis glucan 1,4-alpha-glucosidase triggering host plant immunity as an elicitor. These results lay a foundation for further study of the comprehensive interaction between plants and necrotrophic fungi. PMID:25613865

  11. Involvement of BcStr2 in methionine biosynthesis, vegetative differentiation, multiple stress tolerance and virulence in Botrytis cinerea.

    PubMed

    Shao, Wenyong; Yang, Yalan; Zhang, Yu; Lv, Chiyuan; Ren, Weichao; Chen, Changjun

    2016-04-01

    The Str2 gene encodes a cystathionine γ-synthase that is a key enzyme in methionine (Met) biosynthesis in Saccharomyces cerevisiae. Met plays a critical role in protein synthesis and diverse cellular processes in both eukaryotes and prokaryotes. In this study, we characterized the Str2 orthologue gene BcStr2 in Botrytis cinerea. The BcStr2 mutant was unable to grow on minimal medium (MM). In addition, conidia of the mutant were unable to germinate in water-agar medium within 15 h of incubation. Supplementation with 1 mm Met or 0.5 mg/mL homocysteine, but not 1 mm cysteine or 0.5 mg/mL glutathione, rescued the defect in mycelial growth of the BcStr2 deletion mutant. These results indicate that the enzyme encoded by BcStr2 is involved in the conversion of cysteine into homocysteine. The mutant exhibited decreased conidiation and impaired sclerotium development. In addition, the BcStr2 mutant exhibited increased sensitivity to osmotic and oxidative stresses, cell wall-damaging agents and thermal stress. The mutant demonstrated dramatically decreased virulence on host plant tissues. All of the defects were restored by genetic complementation of the mutant with wild-type BcStr2. Taken together, the results of this study indicate that BcStr2 plays a critical role in the regulation of various cellular processes in B. cinerea. PMID:26176995

  12. Effects of Pseudoalteromonas sp. BC228 on digestive enzyme activity and immune response of juvenile sea cucumber ( Apostichopus japonicus)

    NASA Astrophysics Data System (ADS)

    Ma, Yuexin; Sun, Feixue; Zhang, Congyao; Bao, Pengyun; Cao, Shuqing; Zhang, Meiyan

    2014-12-01

    A marine bacterium, Pseudoalteromonas sp. BC228 was supplemented to feed in a feeding experiment aiming to determine its ability of enhancing the digestive enzyme activity and immune response of juvenile Apostichopus japonicus. Sea cucumber individuals were fed with the diets containing 0 (control), 105, 107 and 109 CFU g-1 diet of BC228 for 45 days. Results showed that intestinal trypsin and lipase activities were significantly enhanced by 107 and 109 CFU g-1 diet of BC228 in comparison with control ( P < 0.01). The phagocytic activity in the coelomocytes of sea cucumber fed the diet supplemented with 107 CFU g-1 diet of BC228 was significantly higher than that of those fed control diet ( P < 0.05). In addition, 105 and 107 CFU g-1 diet of BC228 significantly enhanced lysozyme and phenoloxidase activities in the coelomic fluid of sea cucumber, respectively, in comparison with other diets ( P < 0.01). Sea cucumbers, 10 each diet, were challenged with Vibrio splendidus NB13 after 45 days of feeding. It was found that the cumulative incidence and mortality of sea cucumber fed with BC228 containing diets were lower than those of animals fed control diet. Our findings evidenced that BC228 supplemented in diets improved the digestive enzyme activity of juvenile sea cucumber, stimulated its immune response and enhanced its resistance to the infection of V. splendidus.

  13. Identification of a novel HIV-1 circulating recombinant form (CRF62_BC) in western Yunnan of China.

    PubMed

    Wei, Huamian; His, Jenny; Feng, Yi; Xing, Hui; He, Xiang; Liao, Lingjie; Duan, Song; Ning, Chuanyi; Wang, Nidan; Takebe, Yutaka; Shao, Yiming

    2014-04-01

    We report here a novel HIV-1 circulating recombinant form (CRF62_BC) that was isolated from three epidemiologically unlinked individuals [one from an injecting drug user (IDU); two from heterosexuals] in Dehong prefecture of western Yunnan province. CRF62_BC harbored two subtype B segments in the pol and vpu-env regions in a subtype C backbone. Subregion tree analysis demonstrated that subtype B regions originated from a Thai-B (subtype B') lineage and the subtype C region was from an India C lineage. CRF62_BC is the fourth CRF composed of subtypes B' and C known to date after CRF07_BC, CRF08_BC, and CRF57_BC, which were originally found among IDUs in China. The emergence of CRF62_BC may indicate the continual generation of new recombinant strains in various high-risk populations in western Yunnan. This may complicate the development of effective vaccines to limit the HIV-1 epidemic and increase the difficulty of AIDS prevention and control in China. PMID:24164474

  14. Radiocarbon-based source apportionment of black carbon (BC) in PM 10 aerosols from residential area of suburban Tokyo

    NASA Astrophysics Data System (ADS)

    Uchida, Masao; Kumata, Hidetoshi; Koike, Yasuyo; Tsuzuki, Mikio; Uchida, Tatsuya; Fujiwara, Kitao; Shibata, Yasuyuki

    2010-04-01

    The AMS technique was applied to analyse black carbon (BC), total organic carbon (TOC), and previously reported polycyclic aromatic hydrocarbons (PAHs) in PM 10 aerosols from a residential area, suburban Tokyo, to determine natural abundance of radiocarbon ( 14C), an ideal tracer to distinguish fossil fuel ( 14C-free) from modern biomass combustion sources of pyrolytic products. The 14C concentrations in BC, isolated using the CTO-375 method, were 42% and 30% pMC (in terms of percent Modern Carbon: pMC) in summer and winter, respectively. The 14C concentrations in BC were also compared with those of compound-class specific 14C content of PAHs previously reported for the same samples: they were 45% and 33% pMC in summer and winter, respectively. The 14C signals of BC were identical to those of high molecular weight (MW ⩾ 226, 5-6 rings) PAHs. The resemblance between 14C signals of BC and PAHs can be referred as a 'certificate' for the validity of the BC isolation method employed in this study. Also, it suggests that 14C-BC approach can be a surrogate for PAHs specific 14C analyses to monitor seasonal source variation of combustion-derived pyrolytic products. On the other hand, 14C contents of total organic carbon in 2004 were 61% and 42% pMC in summer and winter, respectively. This is likely attributed to higher contribution of plant activity in summer.

  15. PqsBC, a Condensing Enzyme in the Biosynthesis of the Pseudomonas aeruginosa Quinolone Signal

    PubMed Central

    Drees, Steffen Lorenz; Li, Chan; Prasetya, Fajar; Saleem, Muhammad; Dreveny, Ingrid; Williams, Paul; Hennecke, Ulrich; Emsley, Jonas; Fetzner, Susanne

    2016-01-01

    Pseudomonas aeruginosa produces a number of alkylquinolone-type secondary metabolites best known for their antimicrobial effects and involvement in cell-cell communication. In the alkylquinolone biosynthetic pathway, the β-ketoacyl-(acyl carrier protein) synthase III (FabH)-like enzyme PqsBC catalyzes the condensation of octanoyl-coenzyme A and 2-aminobenzoylacetate (2-ABA) to form the signal molecule 2-heptyl-4(1H)-quinolone. PqsBC, a potential drug target, is unique for its heterodimeric arrangement and an active site different from that of canonical FabH-like enzymes. Considering the sequence dissimilarity between the subunits, a key question was how the two subunits are organized with respect to the active site. In this study, the PqsBC structure was determined to a 2 Å resolution, revealing that PqsB and PqsC have a pseudo-2-fold symmetry that unexpectedly mimics the FabH homodimer. PqsC has an active site composed of Cys-129 and His-269, and the surrounding active site cleft is hydrophobic in character and approximately twice the volume of related FabH enzymes that may be a requirement to accommodate the aromatic substrate 2-ABA. From physiological and kinetic studies, we identified 2-aminoacetophenone as a pathway-inherent competitive inhibitor of PqsBC, whose fluorescence properties could be used for in vitro binding studies. In a time-resolved setup, we demonstrated that the catalytic histidine is not involved in acyl-enzyme formation, but contributes to an acylation-dependent increase in affinity for the second substrate 2-ABA. Introduction of Asn into the PqsC active site led to significant activity toward the desamino substrate analog benzoylacetate, suggesting that the substrate 2-ABA itself supplies the asparagine-equivalent amino function that assists in catalysis. PMID:26811339

  16. Production of inositol trisphosphates upon. cap alpha. -adrenergic stimulation in BC3H-1 muscle cells

    SciTech Connect

    Ambler, S.K.; Thompson, B.; Brown, J.H.; Taylor, P.

    1986-05-01

    Activation of ..cap alpha../sub 1/-adrenergic receptors in BC3H-1 muscle cells rapidly mobilizes intracellular and results in a paradoxically slower accumulation of inositol trisphosphate. A possible explanation for this discrepancy may be provided by the recent findings of Irvine et al. of additional Ins P3 isomers besides the Ca/sup + +/-mobilizing isomer, Ins 1,4,5-P3. They have eluted and separated the inositol phosphates of BC3H-1 cells with an NH/sub 4//sup +/ x HCO/sub 2//sup -//H/sub 3/PO/sub 4/ gradient on a Whatman Partisil 10SAX column using Hewlett-Packard HPLC. Commercial (/sup 3/H)Ins 1,4,5-P3 and (/sup 3/H)inositol phosphates from carbachol-stimulated parotid glands were used as standards. Little or no Ins 1,3,4-P3 could be detected in control or phenylephrine-treated BC3H-1 cells. Ins 1,4,5-P3 followed the pattern of agonist stimulation observed previously. As a positive control, Ins P3 isomers were also measured in 1321N1 astrocytoma cells. Muscarinic stimulation of 1321N1 cells results in both the rapid accumulation of Ins P3 and Ca/sup + +/ mobilization. There is no detectable basal Ins 1,3,4-P3, but carbachol stimulates a rapid production of this compound in 1321N1 cells. Agonist activation also results in a rapid increase in Ins 1,4,5-P3 above basal values. These studies indicate that Ins 1,3,4-P3 does not contribute to the InsP3 signal in BC3H-1 cells and multiple mechanisms may exist for the coupling of receptors to PI turnover.

  17. Observations concerning the quinol oxidation site of the cytochrome bc{sub 1} complex

    SciTech Connect

    Berry, Edward A.; Huang, Li-Shar

    2003-09-07

    A direct hydrogen bond between ubiquinone/quinol bound at the QO site and a cluster-ligand histidine of the iron-sulfur protein (ISP) is described as a major determining factor explaining much experimental data on position of the ISP ectodomain, EPR lineshape and midpoint potential of the iron-sulfur cluster, and the mechanism of the bifurcated electron transfer from ubiquinol to the high and low potential chains of the bc1 complex.

  18. Oh Canada! B.C. ratifies North America's first carbon tax

    SciTech Connect

    Peltier, R.

    2008-08-15

    British Columbia began collecting increased tax revenue on fossil fuels on July 1 with a promise to rebate those taxes through reduced income and business tax rates. This 'revenue recycling' plan makes little progress toward the province's goal to reduce CO{sub 2} emissions 33% by 2020, yet it is hailed by proponents as a legislative milestone. Others believe BC residents are victims of another governmental 'bait and switch' program. This paper examines the legislation. 2 figs.

  19. Capabilities, limitations, and use of BC SAT-R2 conference software

    NASA Technical Reports Server (NTRS)

    Miller, E. F.

    1983-01-01

    The computer software developed for the BC SAT-R2 Conference has certain capabilities and limitations which are described. Capabilities of each major program element are addressed with respect to providing the required functions for planning and output reporting. Limitations arise from the inability to exactly represent certain systems that may be examined. Expected use of the software package during the Conference is outlined.

  20. Draft Genome Assembly of a Filamentous Euendolithic (True Boring) Cyanobacterium, Mastigocoleus testarum Strain BC008

    PubMed Central

    Guida, Brandon S.

    2016-01-01

    Mastigocoleus testarum strain BC008 is a model organism used to study marine photoautotrophic carbonate dissolution. It is a multicellular, filamentous, diazotrophic, euendolithic cyanobacterium ubiquitously found in marine benthic environments. We present an accurate draft genome assembly of 172 contigs spanning 12,700,239 bp with 9,131 annotated genes with an average G+C% of 37.3. PMID:26823575

  1. BcMF9, a novel polygalacturonase gene, is required for both Brassica campestris intine and exine formation

    PubMed Central

    Huang, Li; Ye, Yiqun; Zhang, Yuchao; Zhang, Aihong; Liu, Tingting; Cao, Jiashu

    2009-01-01

    Background and Aims The polygalacturonase (PG) gene family has been found to be enriched in pollen of several species; however, little is currently known about the function of the PG gene in pollen development. To investigate the exact role that the PG gene has played in pollen development and about this family in general, one putative PG gene, Brassica campestris Male Fertility 9 (BcMF9), was isolated from Chinese cabbage (Brassica campestris ssp. chinensis, syn. B. rapa ssp. chinensis) and characterized. Methods RT-PCR, northern blotting and in situ hybridization were used to analyse the expression pattern of BcMF9, and antisense RNA technology was applied to study the function of this gene. Key Results BcMF9 is expressed in particular in the tapetum and microspore during the late stages of pollen development. Antisense RNA transgenic plants that displayed decreased expression of BcMF9 showed pollen morphological defects that resulted in reduced pollen germination efficiency. Transmission electron microscopy revealed that the homogeneous pectic exintine layer of pollen facing the exterior was over-developed and predominantly occupied the intine, reversing the normal proportional distribution of the internal endintine layer and the external exintine in transgenic pollen. Inhibition of BcMF9 also resulted in break-up of the previously formed tectum and baculae from the beginning of the binucleate stage, as a result of premature degradation of tapetum. Conclusions Several lines of evidence, including patterns of BcMF9 expression and phenotypic defects, suggest a sporophytic role in exine patterning, and a gametophytic mode of action of BcMF9 in intine formation. BcMF9 might act as a co-ordinator in the late stages of tapetum degeneration, and subsequently in the regulation of wall material secretion and, in turn, exine formation. BcMF9 might also play a role in intine formation, possibly via regulation of the dynamic metabolism of pectin. PMID:19815569

  2. Podocalyxin Is a Glycoprotein Ligand of the Human Pluripotent Stem Cell-Specific Probe rBC2LCN

    PubMed Central

    Tateno, Hiroaki; Matsushima, Asako; Hiemori, Keiko; Onuma, Yasuko; Ito, Yuzuru; Hasehira, Kayo; Nishimura, Ken; Ohtaka, Manami; Takayasu, Satoko; Nakanishi, Mahito; Ikehara, Yuzuru; Nakanishi, Mio; Ohnuma, Kiyoshi; Chan, Techuan; Toyoda, Masashi; Akutsu, Hidenori; Umezawa, Akihiro; Asashima, Makoto

    2013-01-01

    In comprehensive glycome analysis with a high-density lectin microarray, we have previously shown that the recombinant N-terminal domain of the lectin BC2L-C from Burkholderia cenocepacia (rBC2LCN) binds exclusively to undifferentiated human induced pluripotent stem (iPS) cells and embryonic stem (ES) cells but not to differentiated somatic cells. Here we demonstrate that podocalyxin, a heavily glycosylated type 1 transmembrane protein, is a glycoprotein ligand of rBC2LCN on human iPS cells and ES cells. When analyzed by DNA microarray, podocalyxin was found to be highly expressed in both iPS cells and ES cells. Western and lectin blotting revealed that rBC2LCN binds to podocalyxin with a high molecular weight of more than 240 kDa in undifferentiated iPS cells of six different origins and four ES cell lines, but no binding was observed in either differentiated mouse feeder cells or somatic cells. The specific binding of rBC2LCN to podocalyxin prepared from a large set of iPS cells (138 types) and ES cells (15 types) was also confirmed using a high-throughput antibody-overlay lectin microarray. Alkaline digestion greatly reduced the binding of rBC2LCN to podocalyxin, indicating that the major glycan ligands of rBC2LCN are presented on O-glycans. Furthermore, rBC2LCN was found to exhibit significant affinity to a branched O-glycan comprising an H type 3 structure (Ka, 2.5 × 104 M−1) prepared from human 201B7 iPS cells, indicating that H type 3 is a most probable potential pluripotency marker. We conclude that podocalyxin is a glycoprotein ligand of rBC2LCN on human iPS cells and ES cells. PMID:23526252

  3. Identification of BC005512 as a DNA Damage Responsive Murine Endogenous Retrovirus of GLN Family Involved in Cell Growth Regulation

    PubMed Central

    Wu, Yuanfeng; Qi, Xinming; Gong, Likun; Xing, Guozhen; Chen, Min; Miao, Lingling; Yao, Jun; Suzuki, Takayoshi; Furihata, Chie; Luan, Yang; Ren, Jin

    2012-01-01

    Genotoxicity assessment is of great significance in drug safety evaluation, and microarray is a useful tool widely used to identify genotoxic stress responsive genes. In the present work, by using oligonucleotide microarray in an in vivo model, we identified an unknown gene BC005512 (abbreviated as BC, official full name: cDNA sequence BC005512), whose expression in mouse liver was specifically induced by seven well-known genotoxins (GTXs), but not by non-genotoxins (NGTXs). Bioinformatics revealed that BC was a member of the GLN family of murine endogenous retrovirus (ERV). However, the relationship to genotoxicity and the cellular function of GLN are largely unknown. Using NIH/3T3 cells as an in vitro model system and quantitative real-time PCR, BC expression was specifically induced by another seven GTXs, covering diverse genotoxicity mechanisms. Additionally, dose-response and linear regression analysis showed that expression level of BC in NIH/3T3 cells strongly correlated with DNA damage, measured using the alkaline comet assay,. While in p53 deficient L5178Y cells, GTXs could not induce BC expression. Further functional studies using RNA interference revealed that down-regulation of BC expression induced G1/S phase arrest, inhibited cell proliferation and thus suppressed cell growth in NIH/3T3 cells. Together, our results provide the first evidence that BC005512, a member from GLN family of murine ERV, was responsive to DNA damage and involved in cell growth regulation. These findings could be of great value in genotoxicity predictions and contribute to a deeper understanding of GLN biological functions. PMID:22514700

  4. The effect of the 4MAT learning model on the achievement and motivation of 7th grade students on the subject of particulate nature of matter and an examination of student opinions on the model

    NASA Astrophysics Data System (ADS)

    Aktas, İdris; Bılgın, İbrahim

    2015-01-01

    Background:Many researchers agree that students, especially primary students, have learning difficulties on the 'Particulate Nature of Matter' unit. One reason for this difficulty is not considering individual differences for teaching science. In 4MAT model learning, environment is arranged according to individual differences. Purpose:The purpose of this study is to examine (1) the effects of the 4MAT learning model on the7th grade students' academic achievement and motivation on the 'Particulate Nature of Matter' unit and (2) identify student opinions on the 4MAT model. Sample:The sample consists of 235 students (115 experimental, 120 control) in Turkey. Design and methods:Experimental groups were instructed with the 4MAT model while control groups were instructed with a traditional method. Achievement Test (AchToM) and Motivation Scale (MotScl) were administered to students as pre- and post-tests. Moreover, the opinions of students in the experimental groups on the 4MAT model were ascertained through open-ended questions after the application. Results:According to independent t-test results, statistical difference in favour of the experimental groups was detected between the post-AchToM (ES = 1.43; p < .0001) and post-MotScl (ES = 0.32; p < .05) scores. According to data obtained from the questionnaire, the application of the 4MAT model increases student motivation and participation in the lesson, lessons are more amusing and enjoyable, and the self-confidence of the students increases. Besides these positive opinions, however, a few students stated that the method took too much time, they were not motivated and it did not help them in understanding the subject. Conclusions:The 4MAT model is more effective than traditional method in terms of increasing achievement and motivation. The model takes all learners into account. Thus, the teacher or educator should use the 4MAT model to ensure all students' learning in their classroom.

  5. Uncoupling of the recBC ATPase from DNase by DNA Crosslinked with Psoralen

    PubMed Central

    Karu, Alexander E.; Linn, Stuart

    1972-01-01

    Exonucleolytic cleavage of DNA by the recBC DNase is accompained by a DNA-dependent ATP hydrolysis that ceases when the DNA that has been digested to a limit. On the other hand, DNA that has been crosslinked by 4,5′,8-trimethylpsoralen in the presence of 360-nm light remains an effective cofactor in the ATPase reaction, but is resistant to digestion by the enzyme. Psoralentreated DNA is degraded by pancreatic DNase, micrococcal nuclease, and Escherichia coli B restriction enzyme, but not by Neurospora crassa nuclease, suggesting that crosslinking did not grossly distort the duplex structure of the DNA. The psoralen-DNA is not a potent inhibitor, but competes with single-stranded DNA from bacteriophage fd for the recBC DNase to roughly the same extent as does normal duplex DNA. DNA treated with psoralen in the dark, exposed to 360-nm light in the absence of psoralen, or treated with the intercalating agents ethidium bromide, 9-aminoacridine, ICR-191, or actinomycin D, responds to the enzyme no differently from untreated DNA. However, DNA crosslinked with mitomycin C or nitrogen mustard behaves similarly to psoralen-treated DNA. The relationship of these findings to models for the function and control of the recBC ATPase and nuclease, and the advantages of psoralen as a DNA crosslinking agent, are discussed. PMID:4263506

  6. New Numismatic Evidence about the Comets of Mithradates the Great of Pontus (134 and 119 BC).

    NASA Astrophysics Data System (ADS)

    Molnar, M. R.

    1997-12-01

    The historian, Justinus, tells us that the life of Mithradates the Great of Pontus (ca. 134 - 63 BC) was marked by two unusually large comets: one at his birth in ca. 134 BC and another at his coronation ca. 119 BC. Often these comets are cited as proof that sometimes comets heralded great, good events (such as the Star of Bethlehem.) We now have evidence that counters that notion. Mithradates struck some bronze coins that depict a foreboding hippeus (horse) comet. Pliny, the Roman naturalist, tells us that this kind of comet had plumes much like horses manes in very rapid motion and moving in a circle. The evidence is that the horses mains are synchronic bands. The visibility of these bands indicates that the hippeus comet is a class of comets that had a close encounter with the earth, perhaps on the order of a million kilometers. Hephaistion of Thebes tells us that the hippeus comet foretold the quick fall of kings and tyrants and rapid changes in the affairs of these countries. It is likely that the comet was interpreted as an omen of violent revolution, but Mithradates apparently altered the focus of the portent, namely that the comet signified his struggle to evict the Romans from Asia Minor.

  7. Performance comparison of plasma spray and physical vapor deposition BC23 coatings in the LM2500

    SciTech Connect

    Wortman, D.J.

    1985-11-01

    Operation of US Navy Component Improvement Program LM2500 engines on the GTS Callaghan has provided an at-sea test bed for evaluation of hot corrosion on gas turbine engine components. In a presentation at a previous International Conference on Metallurgical Coatings, (ICMC), comparison of several coatings applied by physical vapor deposition (PVD) techniques were compared after LM2500 service. A three-step coating BC23 consisting of PVD CoCrAl followed by codeposition of hafnium and aluminum and an electroplated platinum layer was identified as the most corrosion-resistant coating of several PVD coatings tested. In this paper, a plasma sprayed version of BC23 is compared to the three-step BC23 coating on LM2500 Stage 2 HPT blades from the GTS Callaghan. The plasma sprayed coating PBC23 was produced by an argon-shrouded plasma spray process using prealloyed CoCrAlHfPt powder. The results showed that in this application, where low temperature hot corrosion (type 2) is the predominant mode of corrosion, the plasma sprayed coatings had less attack. These results are compared to laboratory hot corrosion tests and microprobe analysis to explain the improved corrosion resistance of PBC23.

  8. Smart Oceans BC: Supporting Coastal and Ocean Natural Hazards Mitigation for British Columbia

    NASA Astrophysics Data System (ADS)

    Moran, K.; Insua, T. L.; Pirenne, B.; Hoeberechts, M.; McLean, S.

    2014-12-01

    Smart Oceans BC is a new multi-faceted program to support decision-makers faced with responding to natural disasters and hazards in Canada's Province of British Columbia. It leverages the unique capabilities of Ocean Networks Canada's cabled ocean observatories, NEPTUNE and VENUS to enhance public safety, marine safety and environmental monitoring. Smart Oceans BC combines existing and new marine sensing technology with its robust data management and archive system, Oceans 2.0, to deliver information and science for good ocean management and responsible ocean use. Smart Oceans BC includes new ocean observing infrastructure for: public safety, through natural hazard detection for earthquake groundshaking and near-field tsunamis; marine safety, by monitoring and providing alerts on sea state, ship traffic, and marine mammal presence; and environmental protection, by establishing baseline data in critical areas, and providing real-time environmental observations. Here we present the elements of this new ocean observing initiative that are focused on tsunami and earthquake early warning including cabled and autonomous sensor systems, real-time data delivery, software developments that enable rapid detection, analytics used in notification development, and stakeholder engagement plans.

  9. Sensitivity to Majorana neutrinos in Δ L =2 decays of Bc meson at LHCb

    NASA Astrophysics Data System (ADS)

    Milanés, Diego; Quintero, Néstor; Vera, Carlos E.

    2016-05-01

    The possible existence of Majorana neutrinos can be tested through the study of processes where the total lepton number L is violated by two units (Δ L =2 ). In this work, the production of an on-shell Majorana neutrino with a mass around ˜0.2 GeV to a few GeV is studied in Δ L =2 decays of the Bc meson. We focus on the same-sign di-muon channels: three-body Bc-→π+μ-μ- and four-body Bc-→J /ψ π+μ-μ- and their experimental sensitivity at the LHCb. In both channels, we find that sensitivities on the branching fraction of the order ≲10-7(10-8) might be accessible at the LHC run 2 (future LHC run 3), allowing us to set additional and complementary constraints on the parameter space associated with the mass and mixings of the Majorana neutrino. In particular, bounds can be obtained on the mixing |Vμ N|2˜O (10-5- 10-4) that are similar or better that the ones obtained from heavy meson Δ L =2 decays: D(s) -→π+μ-μ- and B-→π+μ-μ-(D0π+μ-μ-) .

  10. TatBC-Independent TatA/Tat Substrate Interactions Contribute to Transport Efficiency

    PubMed Central

    Taubert, Johannes; Hou, Bo; Risselada, H. Jelger; Mehner, Denise; Lünsdorf, Heinrich; Grubmüller, Helmut; Brüser, Thomas

    2015-01-01

    The Tat system can transport folded, signal peptide-containing proteins (Tat substrates) across energized membranes of prokaryotes and plant plastids. A twin-arginine motif in the signal peptide of Tat substrates is recognized by TatC-containing complexes, and TatA permits the membrane passage. Often, as in the model Tat systems of Escherichia coli and plant plastids, a third component – TatB – is involved that resembles TatA but has a higher affinity to TatC. It is not known why most TatA dissociates from TatBC complexes in vivo and distributes more evenly in the membrane. Here we show a TatBC-independent substrate-binding to TatA from Escherichia coli, and we provide evidence that this binding enhances Tat transport. First hints came from in vivo cross-linking data, which could be confirmed by affinity co-purification of TatA with the natural Tat substrates HiPIP and NrfC. Two positions on the surface of HiPIP could be identified that are important for the TatA interaction and transport efficiency, indicating physiological relevance of the interaction. Distributed TatA thus may serve to accompany membrane-interacting Tat substrates to the few TatBC spots in the cells. PMID:25774531

  11. Cluster analysis of diurnal variations in BC concentration from Multi-Angle Absorption Photometer

    NASA Astrophysics Data System (ADS)

    Han, Y.; KIM, C.; Park, J.; Choi, Y.; Ghim, Y.

    2013-12-01

    Black carbon (BC) is emitted from incomplete combustion of carbon-containing fuels, such as fossil fuels (diesel and coal) and biomass burning (forest fires and burning of agricultural waste). We have measured BC concentration using MAAP (Multi-Angle Absorption Photometer, Model 5012, Thermo Scientific) during the past few years. The measurement site is on the rooftop of the five-story building on the hill (37.02 °N, 127.16 °E, 167 m above sea level), about 35 km southeast of Seoul; there are no major emission sources nearby except a 4-lane road running about 1.4 km to the west. Previous studies reveal that the effects of vehicle emissions are not as direct as urban sites but those of biomass burning are general. Diurnal variations of BC concentration are classified using cluster analysis. Typical patterns are determined to identify the primary emissions and their effects on the concentration level. High concentration episodes are discriminated and major factors that influence the evolution of the episodes are investigated.

  12. Wind Vanes in Ancient Mesopotamia, About 2000-1500 B.C..

    NASA Astrophysics Data System (ADS)

    Neumann, J.; Parpola, S.

    1983-10-01

    A search made of the Sumerian and Akkadian literature for indications of the possible existence of wind vanes in the ancient Mesopotamian civilizations resulted in two discoveries. First, in one Akkadian fable, originally written between about 1800 and 1600 B.C., mention was made of a wind vane. It follows from the context of the fable that the vane was made of wood, while the name of the vane suggests that it was in the shape of a bird. Second, three Sumero-Akkadian vocabularies of this period give three different Sumerian names for the single Akkadian name for vane. The Sumerian names appear to be genuine Sumerian terms and not translations of the Akkadian term. All three Sumerian names suggest that the vanes were made of wood; one of the three may possibly indicate that the vane was made in the form of either a fish (shark?) or a mythological water monster. Since the Sumerian culture flourished before about 2000 B.C. (the Ur III dynasty ruled from about 2100to 2000 B.C.), it seems that in the ancient Mesopotamian civilizations there were wind vanes about 4000 years ago, i.e., about 2000 years earlier than reported in ancient China and classical Greece.

  13. Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1

    PubMed Central

    Capper, Michael J.; O’Neill, Paul M.; Fisher, Nicholas; Strange, Richard W.; Moss, Darren; Ward, Stephen A.; Berry, Neil G.; Lawrenson, Alexandre S.; Hasnain, S. Samar; Biagini, Giancarlo A.; Antonyuk, Svetlana V.

    2015-01-01

    Cytochrome bc1 is a proven drug target in the prevention and treatment of malaria. The rise in drug-resistant strains of Plasmodium falciparum, the organism responsible for malaria, has generated a global effort in designing new classes of drugs. Much of the design/redesign work on overcoming this resistance has been focused on compounds that are presumed to bind the Qo site (one of two potential binding sites within cytochrome bc1) using the known crystal structure of this large membrane-bound macromolecular complex via in silico modeling. Cocrystallization of the cytochrome bc1 complex with the 4(1H)-pyridone class of inhibitors, GSK932121 and GW844520, that have been shown to be potent antimalarial agents in vivo, revealed that these inhibitors do not bind at the Qo site but bind at the Qi site. The discovery that these compounds bind at the Qi site may provide a molecular explanation for the cardiotoxicity and eventual failure of GSK932121 in phase-1 clinical trial and highlight the need for direct experimental observation of a compound bound to a target site before chemical optimization and development for clinical trials. The binding of the 4(1H)-pyridone class of inhibitors to Qi also explains the ability of this class to overcome parasite Qo-based atovaquone resistance and provides critical structural information for future design of new selective compounds with improved safety profiles. PMID:25564664

  14. Observation of the decay B(c)(+) → B(s)(0)π+.

    PubMed

    Aaij, R; Adeva, B; Adinolfi, M; Adrover, C; Affolder, A; Ajaltouni, Z; Albrecht, J; Alessio, F; Alexander, M; Ali, S; Alkhazov, G; Alvarez Cartelle, P; Alves, A A; Amato, S; Amerio, S; Amhis, Y; Anderlini, L; Anderson, J; Andreassen, R; Andrews, J E; Appleby, R B; Aquines Gutierrez, O; Archilli, F; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Baalouch, M; Bachmann, S; Back, J J; Baesso, C; Balagura, V; Baldini, W; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Bauer, Th; Bay, A; Beddow, J; Bedeschi, F; Bediaga, I; Belogurov, S; Belous, K; Belyaev, I; Ben-Haim, E; Bencivenni, G; Benson, S; Benton, J; Berezhnoy, A; Bernet, R; Bettler, M-O; van Beuzekom, M; Bien, A; Bifani, S; Bird, T; Bizzeti, A; Bjørnstad, P M; Blake, T; Blanc, F; Blouw, J; Blusk, S; Bocci, V; Bondar, A; Bondar, N; Bonivento, W; Borghi, S; Borgia, A; Bowcock, T J V; Bowen, E; Bozzi, C; Brambach, T; van den Brand, J; Bressieux, J; Brett, D; Britsch, M; Britton, T; Brook, N H; Brown, H; Bursche, A; Busetto, G; Buytaert, J; Cadeddu, S; Callot, O; Calvi, M; Calvo Gomez, M; Camboni, A; Campana, P; Campora Perez, D; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carranza-Mejia, H; Carson, L; Carvalho Akiba, K; Casse, G; Cassina, L; Castillo Garcia, L; Cattaneo, M; Cauet, Ch; Cenci, R; Charles, M; Charpentier, Ph; Chen, P; Cheung, S-F; Chiapolini, N; Chrzaszcz, M; Ciba, K; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Coca, C; Coco, V; Cogan, J; Cogneras, E; Collins, P; Comerma-Montells, A; Contu, A; Cook, A; Coombes, M; Coquereau, S; Corti, G; Couturier, B; Cowan, G A; Craik, D C; Cunliffe, S; Currie, R; D'Ambrosio, C; David, P; David, P N Y; Davis, A; De Bonis, I; De Bruyn, K; De Capua, S; De Cian, M; De Miranda, J M; De Paula, L; De Silva, W; De Simone, P; Decamp, D; Deckenhoff, M; Del Buono, L; Déléage, N; Derkach, D; Deschamps, O; Dettori, F; Di Canto, A; Dijkstra, H; Dogaru, M; Donleavy, S; Dordei, F; Dosil Suárez, A; Dossett, D; Dovbnya, A; Dupertuis, F; Durante, P; Dzhelyadin, R; Dziurda, A; Dzyuba, A; Easo, S; Egede, U; Egorychev, V; Eidelman, S; van Eijk, D; Eisenhardt, S; Eitschberger, U; Ekelhof, R; Eklund, L; El Rifai, I; Elsasser, Ch; Falabella, A; Färber, C; Farinelli, C; Farry, S; Ferguson, D; Fernandez Albor, V; Ferreira Rodrigues, F; Ferro-Luzzi, M; Filippov, S; Fiore, M; Fitzpatrick, C; Fontana, M; Fontanelli, F; Forty, R; Francisco, O; Frank, M; Frei, C; Frosini, M; Furfaro, E; Gallas Torreira, A; Galli, D; Gandelman, M; Gandini, P; Gao, Y; Garofoli, J; Garosi, P; Garra Tico, J; Garrido, L; Gaspar, C; Gauld, R; Gersabeck, E; Gersabeck, M; Gershon, T; Ghez, Ph; Gibson, V; Giubega, L; Gligorov, V V; Göbel, C; Golubkov, D; Golutvin, A; Gomes, A; Gorbounov, P; Gordon, H; Grabalosa Gándara, M; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graziani, G; Grecu, A; Greening, E; Gregson, S; Griffith, P; Grünberg, O; Gui, B; Gushchin, E; Guz, Yu; Gys, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hall, S; Hamilton, B; Hampson, T; Hansmann-Menzemer, S; Harnew, N; Harnew, S T; Harrison, J; Hartmann, T; He, J; Head, T; Heijne, V; Hennessy, K; Henrard, P; Hernando Morata, J A; van Herwijnen, E; Heß, M; Hicheur, A; Hicks, E; Hill, D; Hoballah, M; Hombach, C; Hulsbergen, W; Hunt, P; Huse, T; Hussain, N; Hutchcroft, D; Hynds, D; Iakovenko, V; Idzik, M; Ilten, P; Jacobsson, R; Jaeger, A; Jans, E; Jaton, P; Jawahery, A; Jing, F; John, M; Johnson, D; Jones, C R; Joram, C; Jost, B; Kaballo, M; Kandybei, S; Kanso, W; Karacson, M; Karbach, T M; Kenyon, I R; Ketel, T; Khanji, B; Kochebina, O; Komarov, I; Koopman, R F; Koppenburg, P; Korolev, M; Kozlinskiy, A; Kravchuk, L; Kreplin, K; Kreps, M; Krocker, G; Krokovny, P; Kruse, F; Kucharczyk, M; Kudryavtsev, V; Kurek, K; Kvaratskheliya, T; La Thi, V N; Lacarrere, D; Lafferty, G; Lai, A; Lambert, D; Lambert, R W; Lanciotti, E; Lanfranchi, G; Langenbruch, C; Latham, T; Lazzeroni, C; Le Gac, R; van Leerdam, J; Lees, J-P; Lefèvre, R; Leflat, A; Lefrançois, J; Leo, S; Leroy, O; Lesiak, T; Leverington, B; Li, Y; Li Gioi, L; Liles, M; Lindner, R; Linn, C; Liu, B; Liu, G; Lohn, S; Longstaff, I; Lopes, J H; Lopez-March, N; Lu, H; Lucchesi, D; Luisier, J; Luo, H; Lupton, O; Machefert, F; Machikhiliyan, I V; Maciuc, F; Maev, O; Malde, S; Manca, G; Mancinelli, G; Maratas, J; Marconi, U; Marino, P; Märki, R; Marks, J; Martellotti, G; Martens, A; Martín Sánchez, A; Martinelli, M; Martinez Santos, D; Martins Tostes, D; Martynov, A; Massafferri, A; Matev, R; Mathe, Z; Matteuzzi, C; Maurice, E; Mazurov, A; McCarthy, J; McNab, A; McNulty, R; McSkelly, B; Meadows, B; Meier, F; Meissner, M; Merk, M; Milanes, D A; Minard, M-N; Molina Rodriguez, J; Monteil, S; Moran, D; Morawski, P; Mordà, A; Morello, M J; Mountain, R; Mous, I; Muheim, F; Müller, K; Muresan, R; Muryn, B; Muster, B; Naik, P; Nakada, T; Nandakumar, R; Nasteva, I; Needham, M; Neubert, S; Neufeld, N; Nguyen, A D; Nguyen, T D; Nguyen-Mau, C; Nicol, M; Niess, V; Niet, R; Nikitin, N; Nikodem, T; Nomerotski, A; Novoselov, A; Oblakowska-Mucha, A; Obraztsov, V; Oggero, S; Ogilvy, S; Okhrimenko, O; Oldeman, R; Orlandea, M; Otalora Goicochea, J M; Owen, P; Oyanguren, A; Pal, B K; Palano, A; Palutan, M; Panman, J; Papanestis, A; Pappagallo, M; Parkes, C; Parkinson, C J; Passaleva, G; Patel, G D; Patel, M; Patrick, G N; Patrignani, C; Pavel-Nicorescu, C; Pazos Alvarez, A; Pearce, A; Pellegrino, A; Penso, G; Pepe Altarelli, M; Perazzini, S; Perez Trigo, E; Pérez-Calero Yzquierdo, A; Perret, P; Perrin-Terrin, M; Pescatore, L; Pesen, E; Pessina, G; Petridis, K; Petrolini, A; Phan, A; Picatoste Olloqui, E; Pietrzyk, B; Pilař, T; Pinci, D; Playfer, S; Plo Casasus, M; Polci, F; Polok, G; Poluektov, A; Polycarpo, E; Popov, A; Popov, D; Popovici, B; Potterat, C; Powell, A; Prisciandaro, J; Pritchard, A; Prouve, C; Pugatch, V; Puig Navarro, A; Punzi, G; Qian, W; Rademacker, J H; Rakotomiaramanana, B; Rangel, M S; Raniuk, I; Rauschmayr, N; Raven, G; Redford, S; Reid, M M; Dos Reis, A C; Ricciardi, S; Richards, A; Rinnert, K; Rives Molina, V; Roa Romero, D A; Robbe, P; Roberts, D A; Rodrigues, A B; Rodrigues, E; Rodriguez Perez, P; Roiser, S; Romanovsky, V; Romero Vidal, A; Rouvinet, J; Ruf, T; Ruffini, F; Ruiz, H; Ruiz Valls, P; Sabatino, G; Saborido Silva, J J; Sagidova, N; Sail, P; Saitta, B; Salustino Guimaraes, V; Sanmartin Sedes, B; Santacesaria, R; Santamarina Rios, C; Santovetti, E; Sapunov, M; Sarti, A; Satriano, C; Satta, A; Savrie, M; Savrina, D; Schiller, M; Schindler, H; Schlupp, M; Schmelling, M; Schmidt, B; Schneider, O; Schopper, A; Schune, M-H; Schwemmer, R; Sciascia, B; Sciubba, A; Seco, M; Semennikov, A; Senderowska, K; Sepp, I; Serra, N; Serrano, J; Seyfert, P; Shapkin, M; Shapoval, I; Shatalov, P; Shcheglov, Y; Shears, T; Shekhtman, L; Shevchenko, O; Shevchenko, V; Shires, A; Silva Coutinho, R; Sirendi, M; Skidmore, N; Skwarnicki, T; Smith, N A; Smith, E; Smith, E; Smith, J; Smith, M; Sokoloff, M D; Soler, F J P; Soomro, F; Souza, D; Souza De Paula, B; Spaan, B; Sparkes, A; Spradlin, P; Stagni, F; Stahl, S; Steinkamp, O; Stevenson, S; Stoica, S; Stone, S; Storaci, B; Straticiuc, M; Straumann, U; Subbiah, V K; Sun, L; Sutcliffe, W; Swientek, S; Syropoulos, V; Szczekowski, M; Szczypka, P; Szilard, D; Szumlak, T; T'jampens, S; Teklishyn, M; Teodorescu, E; Teubert, F; Thomas, C; Thomas, E; van Tilburg, J; Tisserand, V; Tobin, M; Tolk, S; Tonelli, D; Topp-Joergensen, S; Torr, N; Tournefier, E; Tourneur, S; Tran, M T; Tresch, M; Tsaregorodtsev, A; Tsopelas, P; Tuning, N; Ubeda Garcia, M; Ukleja, A; Ustyuzhanin, A; Uwer, U; Vagnoni, V; Valenti, G; Vallier, A; Vazquez Gomez, R; Vazquez Regueiro, P; Vázquez Sierra, C; Vecchi, S; Velthuis, J J; Veltri, M; Veneziano, G; Vesterinen, M; Viaud, B; Vieira, D; Vilasis-Cardona, X; Vollhardt, A; Volyanskyy, D; Voong, D; Vorobyev, A; Vorobyev, V; Voß, C; Voss, H; de Vries, J A; Waldi, R; Wallace, C; Wallace, R; Wandernoth, S; Wang, J; Ward, D R; Watson, N K; Webber, A D; Websdale, D; Whitehead, M; Wicht, J; Wiechczynski, J; Wiedner, D; Wiggers, L; Wilkinson, G; Williams, M P; Williams, M; Wilson, F F; Wimberley, J; Wishahi, J; Wislicki, W; Witek, M; Wotton, S A; Wright, S; Wu, S; Wyllie, K; Xie, Y; Xing, Z; Yang, Z; Yuan, X; Yushchenko, O; Zangoli, M; Zavertyaev, M; Zhang, F; Zhang, L; Zhang, W C; Zhang, Y; Zhelezov, A; Zhokhov, A; Zhong, L; Zvyagin, A

    2013-11-01

    The result of a search for the decay B(c)(+) → B(s)(0) π+ is presented, using the B(s)(0) → D(s)(-)π+ and B(s)(0) → J/ψ Ø channels. The analysis is based on a data sample of pp collisions collected with the LHCb detector, corresponding to an integrated luminosity of 1 fb(-1) taken at a center-of-mass energy of 7 TeV, and 2 fb(-1) taken at 8 TeV. The decay B(c)(+) → B(s)(0)π+ is observed with significance in excess of 5 standard deviations independently in both decay channels. The measured product of the ratio of cross sections and branching fraction is [σ(B(c)(+))/σ(B(s)(0))] × B(B(c)(+)→ B(s)(0)π+) = [2.37 ± 0.31 (stat)± 0.11 (syst)(-0.13)(+0.17)(τ(B)(c)(+)))] × 10(-3), in the pseudorapidity range 2<η(B)<5, where the first uncertainty is statistical, the second is systematic, and the third is due to the uncertainty on the B(c)(+) lifetime. This is the first observation of a B meson decaying to another B meson via the weak interaction. PMID:24237507

  15. Bc exclusive decays to charmonium and a light meson at next-to-leading order accuracy

    NASA Astrophysics Data System (ADS)

    Qiao, Cong-Feng; Sun, Peng; Yang, Deshan; Zhu, Rui-Lin

    2014-02-01

    In this paper, we study the Bc-meson exclusive decays to S-wave charmonia and light pseudoscalar or vector mesons, i.e., π, K, ρ, and K* at the next-to-leading order (NLO) in the QCD coupling. The nonfactorizable contribution is included, which is absent in traditional naive factorization. Numerical results show that NLO QCD corrections markedly enhance the branching ratio with a K factor of 1.75 for Bc±→ηcπ ± and 1.31 for Bc±→J/ψπ± using certain input parameters. And the theoretical uncertainties for their branching ratios are reduced compared with that of direct tree-level calculation. In order to investigate the asymptotic behavior, the analytic form is obtained in the heavy quark limit, i.e., mb→∞. We note that annihilation topologies contribute trivia in this limit, and the corrections at leading order in z=mc/mb expansion come from form factors and hard spectator interactions. At last, some related phenomenologies are also discussed.

  16. Computational discovery of picomolar Q(o) site inhibitors of cytochrome bc1 complex.

    PubMed

    Hao, Ge-Fei; Wang, Fu; Li, Hui; Zhu, Xiao-Lei; Yang, Wen-Chao; Huang, Li-Shar; Wu, Jia-Wei; Berry, Edward A; Yang, Guang-Fu

    2012-07-11

    A critical challenge to the fragment-based drug discovery (FBDD) is its low-throughput nature due to the necessity of biophysical method-based fragment screening. Herein, a method of pharmacophore-linked fragment virtual screening (PFVS) was successfully developed. Its application yielded the first picomolar-range Q(o) site inhibitors of the cytochrome bc(1) complex, an important membrane protein for drug and fungicide discovery. Compared with the original hit compound 4 (K(i) = 881.80 nM, porcine bc(1)), the most potent compound 4f displayed 20 507-fold improved binding affinity (K(i) = 43.00 pM). Compound 4f was proved to be a noncompetitive inhibitor with respect to the substrate cytochrome c, but a competitive inhibitor with respect to the substrate ubiquinol. Additionally, we determined the crystal structure of compound 4e (K(i) = 83.00 pM) bound to the chicken bc(1) at 2.70 Å resolution, providing a molecular basis for understanding its ultrapotency. To our knowledge, this study is the first application of the FBDD method in the discovery of picomolar inhibitors of a membrane protein. This work demonstrates that the novel PFVS approach is a high-throughput drug discovery method, independent of biophysical screening techniques. PMID:22690928

  17. Potyviral resistance derived from cultivars of Phaseolus vulgaris carrying bc-3 is associated with the homozygotic presence of a mutated eIF4E allele

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Eukaryotic translation initiation factors (eIFs) play a central role in potyviral infection. Accordingly, mutations in the gene encoding eIF4E have been identified as a source of recessive resistance in several plant species. In common bean, Phaseolus vulgaris, four recessive genes, bc-1, bc-2, bc-3...

  18. BC University Outcomes for Direct Entry and Transfer Students: Comparison of the Class of 2000 and Class of 1996 Five Years after Graduation. Research Results

    ERIC Educational Resources Information Center

    Karlinski, Jean

    2007-01-01

    The University of British Columbia's Planning and Institutional Research office prepared a research report for the BC Council on Admissions and Transfer (BCCAT) on the BC university graduating class of 1996 five years later. The report compared the outcomes for those students who were admitted to SFU, UBC, UNBC, and UVic as BC direct entry with…

  19. Structure and Proposed Activity of a Member of the VapBC Family of Toxin-Antitoxin Systems: VapBC-5 from Mycobacterium tuberculosis

    SciTech Connect

    Miallau, L.; Faller, M.; Chiang, J.; Arbing, M.; Guo, F.; Cascio, D.; Eisenberg, D.

    2009-03-02

    In prokaryotes, cognate toxin-antitoxin pairs have long been known, but no three-dimensional structure has been available for any given complex from Mycobacterium tuberculosis. Here we report the crystal structure and activity of a member of the VapBC family of complexes from M. tuberculosis. The toxin VapC-5 is a compact, 150 residues, two domain {alpha}/{beta} protein. Bent around the toxin is the VapB-5 antitoxin, a 33-residue {alpha}-helix. Assays suggest that the toxin is an Mg-enabled endoribonuclease, inhibited by the antitoxin. The lack of DNase activity is consistent with earlier suggestions that the complex represses its own operon. Furthermore, analysis of the interactions in the binding of the antitoxin to the toxin suggest that exquisite control is required to protect the bacteria cell from toxic VapC-5.

  20. Drastic Aridification Caused the Decline of Oasis Civilizations on the Silk Route during the Eighth Century

    NASA Astrophysics Data System (ADS)

    Wei, K.; Song, S.; Huang, C.

    2003-12-01

    Availability of water, and response to shortage of it, plays an important role in shaping human history. Near a century ago, Ellsworth Huntington (1907) suggested that the developments of ancient civilizations in Inner Asian and their invasions into China and Europe were pulsed by climatic changes. In revisiting this proposition, here we present a paleoclimatic record of the past 5000 years deduced from carbon isotopic ratio of organic carbon and percentage of aragonite in bulk sediments of a radiometrically dated sedimentary core of Lake Bosten, Xinjiang, China. Together the two proxies of aridity provide a detailed record of climatic fluctuation of the Inner Asia. The arid periods are well characterized by high content of authigenic aragonite and heavier values of carbon isotopic ratio of organic carbon in the bulk sediments (implying dominance of C4 plants which thrived under arid condition). Conversely, the humid/wet periods are marked by lighter carbon isotopic values (indicating presence of C3 plants of humid climateœcand absence of aragonite. The Western Region (Xi-Y"1) area of China enjoyed a long period of stable and humid condition from 2nd century B.C. to the 8th century when many oasis city-states were established and Buddhism spread from India. A drastic deterioration of climate during the eighth century appears to cause the decline of those once strived ancient civilizations in the eastern side of the Tarim Basin along the Silk Routes.

  1. Two Centuries of Soil Conservation.

    ERIC Educational Resources Information Center

    Helms, Douglas

    1991-01-01

    Narrates U.S. soil conservation history since the late eighteenth century. Discusses early practices such as contour plowing. Profiles individuals who promoted soil conservation and were largely responsible for the creation of the Soil Conservation Service. Explains the causes of erosion and how soil conservation districts help farmers prevent…

  2. Selenography in the seventeenth century.

    NASA Astrophysics Data System (ADS)

    Whitaker, E. A.

    Contents: 1. Pre-telescopic observations. 2. The first telescopic observations. 3. Galileo's lunar observations. 4. Two new selenographical programmes. 5. A flurry of activity. 6. Hevelius and his Selenographia. 7. Riccioli, Grimaldi, and nomenclature. 8. Robert Hooke and selenology. 9. Cassini and La Hire. 10. Other seventeenth-century selenography. 11. Conclusion.

  3. Twenty-first-century science.

    PubMed Central

    Greenwood, M R

    1995-01-01

    Scientific life is changing in fundamental ways as the twenty-first century approaches. Advances in technology are changing methods of scientific communications and dissemination of information, while diminishing resources lead to stabilization, politicization, increased public oversight, and the potential for significant downsizing. Libraries can foster the crucial interdisciplinary connections necessary to forge a new vision of scholarship. PMID:7703945

  4. Physics in the Twentieth Century

    ERIC Educational Resources Information Center

    Weisskopf, Victor F.

    1970-01-01

    Provides a review of the great discoveries, theoretical concepts and development of physics in the 20th century. The growth and significance of diverse fields such as quantum theory, relativity theory, atomic physics, molecular physics, the physics of the solid state, nuclear physics, astrophysics, plasma physics, and particle physics are…

  5. Three Centuries of American Inequality.

    ERIC Educational Resources Information Center

    Lindert, Peter H.; Williamson, Jeffrey G.

    Income inequality in the United States displays considerable variance since the seventeenth century. There is no eternal constancy to the degree of inequality in total income, in labor earnings, or in income from conventional nonhuman wealth either before or after the effects of government taxes and spending. When all the necessary adjustments to…

  6. The measure for black carbon (BC) and dust in the glaciers of China: a review and prospect

    NASA Astrophysics Data System (ADS)

    Ming, J.; Xiao, C.; Qin, D.

    2008-12-01

    During 2004-2006, black carbon concentrations were measured in the snow and ice sampled from the glaciers in west China. The investigated regions could be aligned as follows based on the BC concentrations in the surface snow for the glaciers: the Tianshan Mountains > the central Tibetan Plateau (TP) > the Pamirs > the Qilian Mountians > the Himalayas. This distribution could be attributed to the elevations of the glaciers (higher concentration at lower altitude), the topography of the TP, strong melting in some glaciers, and more regional emissions. Probably significant impacts on the albedos of the glacier surfaces could be caused by heavy BC deposits, and the estimated reduced albedos on the glaciers are 9.8% (Zhadang glacier), 8.7% (Miao'ergou Riverhead No.3 glacier), and 6.8% (Haxilegen River No.48 glacier), and 6.2% (Dongkemadi glacier), and 5.3% (La'nong glacier), and 4.2% (Muztagata glacier), and etc. The East Rongbuk glacier was located on the central part of the Himalayas with a mean elevation higher than 6300 m, and in 2002 a shallow ice core was drilled on it. BC concentrations were measured throughout the ice core. In the past 50 yrs, BC concentrations showed fluctuations in the earlier 40 yrs, whereas showed a dramatic increasing tread in the most recent decade (since the 1990s) and exceeded 50 μg kg-1 in the summer of 2001. Trajectory analysis indicated BC was dominantly transported by monsoons in summers and by westerlies in other seasons, and BC emitted from South Asia in summers dominated the varying trend of concentrations in the ice core and caused higher concentration in summer than that in other season. Significant increasing BC concentration caused increasing radiative forcing since the 1990s, which exceeded 4.5 W m-2 in the summer of 2001 as calculated by a Snow-Ice-Aerosol Radiative (SNICAR) model. During the summer and fall of 2008, a plan of sampling snow in the snow pits on the nine glaciers distributed on a transection from the north

  7. [Mercury (and...) through the centuries].

    PubMed

    Kłys, Małgorzata

    2010-01-01

    Mercury has a long history, fascinating in its many aspects. Through the centuries--from ancient times to the present day--the metal in its various forms, also known under the name "quicksilver", accompanied the man and was used for diversified purposes. Today, mercury is employed in manufacturing thermometers, barometers, vacuum pumps and explosives. It is also used in silver and gold mining processes. Mercury compounds play a significant role in dentistry, pharmaceutical industry and crop protection. The contemporary use of mercury markedly decreases, but historically speaking, the archives abound in materials that document facts and events occurring over generations and the immense intellectual effort aiming at discovering the true properties and mechanisms of mercury activity. Mercury toxicity, manifested in destruction of biological membranes and binding of the element with proteins, what disturbs biochemical processes occurring in the body, was discovered only after many centuries of the metal exerting its effect on the lives of individuals and communities. For centuries, mercury was present in the work of alchemists, who searched for the universal essence or quintessence and the so-called philosopher's stone. In the early modern era, between the 16th and 19th centuries, mercury was used to manufacture mirrors. Mercury compounds were employed as a medication against syphilis, which plagued mankind for more than four hundred years--from the Middle Ages till mid 20th century, when the discovery of penicillin became the turning point. This extremely toxic therapy resulted in much suffering, individual tragedies, chronic poisonings leading to fatalities and dramatic sudden deaths. In the last fifty years, there even occurred attempts of mentally imbalanced individuals at injecting themselves with metallic mercury, also as a performance-enhancing drug. Instances of mass mercury poisoning occurred many times in the past in consequence of eating food products

  8. Inhibition of cytochrome bc1 as a strategy for single-dose, multi-stage antimalarial therapy.

    PubMed

    Stickles, Allison M; Ting, Li-Min; Morrisey, Joanne M; Li, Yuexin; Mather, Michael W; Meermeier, Erin; Pershing, April M; Forquer, Isaac P; Miley, Galen P; Pou, Sovitj; Winter, Rolf W; Hinrichs, David J; Kelly, Jane X; Kim, Kami; Vaidya, Akhil B; Riscoe, Michael K; Nilsen, Aaron

    2015-06-01

    Single-dose therapies for malaria have been proposed as a way to reduce the cost and increase the effectiveness of antimalarial treatment. However, no compound to date has shown single-dose activity against both the blood-stage Plasmodium parasites that cause disease and the liver-stage parasites that initiate malaria infection. Here, we describe a subset of cytochrome bc1 (cyt bc1) inhibitors, including the novel 4(1H)-quinolone ELQ-400, with single-dose activity against liver, blood, and transmission-stage parasites in mouse models of malaria. Although cyt bc1 inhibitors are generally classified as slow-onset antimalarials, we found that a single dose of ELQ-400 rapidly induced stasis in blood-stage parasites, which was associated with a rapid reduction in parasitemia in vivo. ELQ-400 also exhibited a low propensity for drug resistance and was active against atovaquone-resistant P. falciparum strains with point mutations in cyt bc1. Ultimately, ELQ-400 shows that cyt bc1 inhibitors can function as single-dose, blood-stage antimalarials and is the first compound to provide combined treatment, prophylaxis, and transmission blocking activity for malaria after a single oral administration. This remarkable multi-stage efficacy suggests that metabolic therapies, including cyt bc1 inhibitors, may be valuable additions to the collection of single-dose antimalarials in current development. PMID:25918204

  9. Inhibition of Cytochrome bc1 as a Strategy for Single-Dose, Multi-Stage Antimalarial Therapy

    PubMed Central

    Stickles, Allison M.; Ting, Li-Min; Morrisey, Joanne M.; Li, Yuexin; Mather, Michael W.; Meermeier, Erin; Pershing, April M.; Forquer, Isaac P.; Miley, Galen P.; Pou, Sovitj; Winter, Rolf W.; Hinrichs, David J.; Kelly, Jane X.; Kim, Kami; Vaidya, Akhil B.; Riscoe, Michael K.; Nilsen, Aaron

    2015-01-01

    Single-dose therapies for malaria have been proposed as a way to reduce the cost and increase the effectiveness of antimalarial treatment. However, no compound to date has shown single-dose activity against both the blood-stage Plasmodium parasites that cause disease and the liver-stage parasites that initiate malaria infection. Here, we describe a subset of cytochrome bc1 (cyt bc1) inhibitors, including the novel 4(1H)-quinolone ELQ-400, with single-dose activity against liver, blood, and transmission-stage parasites in mouse models of malaria. Although cyt bc1 inhibitors are generally classified as slow-onset antimalarials, we found that a single dose of ELQ-400 rapidly induced stasis in blood-stage parasites, which was associated with a rapid reduction in parasitemia in vivo. ELQ-400 also exhibited a low propensity for drug resistance and was active against atovaquone-resistant P. falciparum strains with point mutations in cyt bc1. Ultimately, ELQ-400 shows that cyt bc1 inhibitors can function as single-dose, blood-stage antimalarials and is the first compound to provide combined treatment, prophylaxis, and transmission blocking activity for malaria after a single oral administration. This remarkable multi-stage efficacy suggests that metabolic therapies, including cyt bc1 inhibitors, may be valuable additions to the collection of single-dose antimalarials in current development. PMID:25918204

  10. Genetic Control of L-a and L-(Bc) Dsrna Copy Number in Killer Systems of SACCHAROMYCES CEREVISIAE

    PubMed Central

    Ball, Steven G.; Tirtiaux, Catherine; Wickner, Reed B.

    1984-01-01

    M dsRNA in yeast encodes a toxin precursor and immunity protein, whereas L-A dsRNA encodes the 81,000-dalton major protein of the intracellular particles in which both L-A and M are found. L-(BC) dsRNA(s) are found in particles with different coat proteins. We find that M dsRNA lowers the copy number of L-A, but not L-(BC). The SKI gene products lower the copy number of L-(BC), L-A, M1 and M2. This is the first known interaction of L-(BC) with any element of the killer systems. The MAK3, MAK10 and PET18 gene products are necessary for L-A maintenance and replication, but mutations in these genes do not affect L-(BC) copy number. Mutations in MAK1, MAK4, MAK7, MAK17 and MAK24 do not detectably affect copy number of L-(BC) or L-A. PMID:17246214

  11. Detection of intra-brain cytoplasmic 1 (BC1) long noncoding RNA using graphene oxide-fluorescence beacon detector

    PubMed Central

    Kim, Mee Young; Hwang, Do Won; Li, Fangyuan; Choi, Yoori; Byun, Jung Woo; Kim, Dongho; Kim, Jee-Eun; Char, Kookheon; Lee, Dong Soo

    2016-01-01

    Detection of cellular expression of long noncoding RNAs (lncRNAs) was elusive due to the ambiguity of exposure of their reactive sequences associated with their secondary/tertiary structures and dynamic binding of proteins around lncRNAs. Herein, we developed graphene-based detection techniques exploiting the quenching capability of graphene oxide (GO) flakes for fluorescent dye (FAM)-labeled single-stranded siRNAs and consequent un-quenching by their detachment from GO by matching lncRNAs. A brain cytoplasmic 1 (BC1) lncRNA expression was significantly decreased by a siRNA, siBC1–1. GO quenched the FAM-labeled siBC1–1 peptide nucleic acid (PNA) probe, and this quenching was recovered by BC1. While FAM-siBC1–1-PNA-GO complex transfected spontaneously mouse or human neural stem cells, fluorescence was recovered only in mouse cells having high BC1 expression. Fluorescent dye-labeled single-stranded RNA-GO probe could detect the reactive exposed nucleic acid sequence of a cytoplasmic lncRNA expressing in the cytoplasm, which strategy can be used as a detection method of lncRNA expression. PMID:26997297

  12. The structure, stability, and electronic properties of ultra-thin BC2N nanotubes: a first-principles study.

    PubMed

    Wang, Yue; Zhang, Juan; Huang, Gang; Yao, Xinhua; Shao, Qingyi

    2014-12-01

    Rapid developments of the silicon electronics industry have close to the physical limits and nanotube materials are the ideal materials to replace silicon for the preparation of next generation electronic devices. Boron-carbon-nitrogen nanotubes (BCNNT) can be formed by joining carbon nanotube (CNT) and boron nitride nanotube (BNNT) segments, and BC2N nanotubes have been widely and deeply studied. Here, we employed first-principles calculations based on density function theory (DFT) to study the structure, stability, and electronic properties of ultra thin (4 Å diameter) BC2N nanotubes. Our results showed that the cross sections of BC2N nanotubes can transform from round to oval when CNT and BNNT segments are parallel to the tube axis. It results when the curvature of BNNT segments become larger than CNT segments. Further, we found the stability of BC2N nanotubes is sensitive to the number of B-N bonds, and the phase segregation of BNNT and CNT segments is energetically favored. We also obtained that all (3,3) BC2N nanotubes are semiconductor, whereas (5,0) BC2N nanotubes are conductor when CNT and BNNT segments are perpendicular to the tube axis; and semiconductor when CNT and BNNT segments are parallel to the tube axis. These electronic properties are abnormal when compared to the relative big ones. PMID:25451142

  13. Detection of intra-brain cytoplasmic 1 (BC1) long noncoding RNA using graphene oxide-fluorescence beacon detector.

    PubMed

    Kim, Mee Young; Hwang, Do Won; Li, Fangyuan; Choi, Yoori; Byun, Jung Woo; Kim, Dongho; Kim, Jee-Eun; Char, Kookheon; Lee, Dong Soo

    2016-01-01

    Detection of cellular expression of long noncoding RNAs (lncRNAs) was elusive due to the ambiguity of exposure of their reactive sequences associated with their secondary/tertiary structures and dynamic binding of proteins around lncRNAs. Herein, we developed graphene-based detection techniques exploiting the quenching capability of graphene oxide (GO) flakes for fluorescent dye (FAM)-labeled single-stranded siRNAs and consequent un-quenching by their detachment from GO by matching lncRNAs. A brain cytoplasmic 1 (BC1) lncRNA expression was significantly decreased by a siRNA, siBC1-1. GO quenched the FAM-labeled siBC1-1 peptide nucleic acid (PNA) probe, and this quenching was recovered by BC1. While FAM-siBC1-1-PNA-GO complex transfected spontaneously mouse or human neural stem cells, fluorescence was recovered only in mouse cells having high BC1 expression. Fluorescent dye-labeled single-stranded RNA-GO probe could detect the reactive exposed nucleic acid sequence of a cytoplasmic lncRNA expressing in the cytoplasm, which strategy can be used as a detection method of lncRNA expression. PMID:26997297

  14. Source sector and region contributions to BC and PM2.5 in Central Asia

    DOE PAGESBeta

    Kulkarni, S.; Sobhani, N.; Miller-Schulze, J. P.; Shafer, M. M.; Schauer, J. J.; Solomon, P. A.; Saide, P. E.; Spak, S. N.; Cheng, Y. F.; Denier van der Gon, H. A. C.; et al

    2015-02-18

    Particulate matter (PM) mass concentrations, seasonal cycles, source sector, and source region contributions in Central Asia (CA) are analyzed for the period April 2008–July 2009 using the Sulfur Transport and dEposition Model (STEM) chemical transport model and modeled meteorology from the Weather Research and Forecasting (WRF) model. Predicted aerosol optical depth (AOD) values (annual mean value ~0.2) in CA vary seasonally, with lowest values in the winter. Surface PM2.5 concentrations (annual mean value ~10 μg m-3) also exhibit a seasonal cycle, with peak values and largest variability in the spring/summer, and lowest values and variability in the winter (hourly valuesmore » from 2 to 90 μg m-3). Surface concentrations of black carbon (BC) (mean value ~0.1 μg m-3) show peak values in the winter. The simulated values are compared to surface measurements of AOD as well as PM2.5, PM10, BC, and organic carbon (OC) mass concentrations at two regional sites in Kyrgyzstan (Lidar Station Teplokluchenka (LST) and Bishkek). The predicted values of AOD and PM mass concentrations and their seasonal cycles are fairly well captured. The carbonaceous aerosols are underpredicted in winter, and analysis suggests that the winter heating emissions are underestimated in the current inventory. Dust, from sources within and outside CA, is a significant component of the PM mass and drives the seasonal cycles of PM and AOD. On an annual basis, the power and industrial sectors are found to be the most important contributors to the anthropogenic portion of PM2.5. Residential combustion and transportation are shown to be the most important sectors for BC. Biomass burning within and outside the region also contributes to elevated PM and BC concentrations. The analysis of the transport pathways and the variations in particulate matter mass and composition in CA demonstrates that this region is strategically located to characterize regional and intercontinental transport of

  15. Direct evidence for the existence of dairying farms in prehistoric Central Europe (4th millennium BC).

    PubMed

    Spangenberg, Jorge E; Matuschik, Irenaus; Jacomet, Stephanie; Schibler, Joerg

    2008-06-01

    The molecular and isotopic chemistry of organic residues from archaeological potsherds was used to obtain further insight into the dietary trends and economies at the Constance lake-shore Neolithic settlements. The archaeological organic residues from the Early Late Neolithic (3922-3902 BC) site Hornstaad-Hornle IA/Germany are, at present, the oldest archaeological samples analysed at the Institute of Mineralogy and Geochemistry of the University of Lausanne. The approach includes 13C/12C and 15N/14N ratios of the bulk organic residues, fatty acids distribution and 13C/12C ratios of individual fatty acids. The results are compared with those obtained from the over 500 years younger Neolithic (3384-3370 BC) settlement of Arbon Bleiche 3/Switzerland and with samples of modern vegetable oils and fat of animals that have been fed exclusively on C3 forage grasses. The overall fatty acid composition (C9 to C24 range, maximizing at C14 and C16), the bulk 13C/12C and 15N/14N ratios (delta13C, delta15N) and the 13C/12C ratios of palmitic (C16:0), stearic (C18:0) and oleic acids (C18:1) of the organic residues indicate that most of the studied samples (25 from 47 samples and 5 from 41 in the delta13C18:0 vs. delta13C16:0 and delta13C18:0 vs. delta13C18:1 diagrams, respectively) from Hornstaad-Hornle IA and Arbon Bleiche 3 sherds contain fat residues of pre-industrial ruminant milk, and young suckling calf/lamb adipose. These data provide direct proof of milk and meat (mainly from young suckling calves) consumption and farming practices for a sustainable dairying in Neolithic villages in central Europe around 4000 BC.dagger. PMID:18569190

  16. A Trick to Improve the Efficiency of Generating Unweighted $B_c$ Events from BCVEGPY

    SciTech Connect

    Wang, Xian-You; Wu, Xing-Gang; /Chongqing U. /SLAC

    2012-09-14

    In the present paper, we provide an addendum to improve the efficiency of generating unweighted events within PYTHIA environment for the generator BCVEGPY2.1 [C.H. Chang, J.X. Wang, X.G. Wu, Comput. Phys. Commun. 174 (2006) 241]. This trick is helpful for experimental simulation. Moreover, the BCVEGPY output has also been improved, i.e. one Les Houches Event common block has been added so as to generate a standard Les Houches Event file that contains the information of the generated Bc meson and the accompanying partons, which can be more conveniently used for further simulation.

  17. Harm-reduction strategies weapon of choice in BC's battle with drug addiction.

    PubMed Central

    Kent, H

    1996-01-01

    British Columbia, which holds the dubious distinction of being the country's heroin capital, has introduced a number of programs in an attempt to reduce the number of drug-overdose deaths. A BC coroner who headed a provincial government task force into overdose fatalities in 1994 has recommended a number of harm-reduction strategies such as needle exchanges to reduce the negative consequences associated with illicit drug use. In addition, the College of Physicians and Surgeons of British Columbia is a world leader in methadone maintenance, with 1800 patients and 250 physicians registered in the program. PMID:8804264

  18. OPS MCC level B/C formulation requirements: Area targets and space volumes processor

    NASA Technical Reports Server (NTRS)

    Bishop, M. J., Jr.

    1979-01-01

    The level B/C mathematical specifications for the area targets and space volume processor (ATSVP) as well as the characteristics of the system are provided. The mathematical equation necessary to determine whether the spacecraft lies within the area target or space volume is presented. A semianalytical technique for predicting the acquisition of signal (AOS) and loss of signal (LOS) time periods is discussed. A functional overview of the ATSVP which includes an outline of the process required to determine precise AOS and LOS times are given.

  19. Is QSO 1146 + 111B,C due to lensing by a cosmic string?

    NASA Technical Reports Server (NTRS)

    Gott, J. R., III

    1986-01-01

    A newly discovered lens candidate, QSO 1146 + 111B,C, is discussed which appears to consist of two images of equal brightness of a quasar at redshift 1.01 separated by 2.6 arcmin. If this is produced by a cosmic string, its mass per unit length is about 4.0 x 10 to the 23rd g/cm or more. This value is large enough to be interesting for string-assisted galaxy formation and near the upper limits implied by the isotropy of the cosmic microwave background and constraints on gravitational radiation.

  20. First observation of the decay B(c)+ → J/ψπ(+) π- π+.

    PubMed

    Aaij, R; Abellan Beteta, C; Adeva, B; Adinolfi, M; Adrover, C; Affolder, A; Ajaltouni, Z; Albrecht, J; Alessio, F; Alexander, M; Ali, S; Alkhazov, G; Alvarez Cartelle, P; Alves, A A; Amato, S; Amhis, Y; Anderson, J; Appleby, R B; Aquines Gutierrez, O; Archilli, F; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Bachmann, S; Back, J J; Balagura, V; Baldini, W; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Bates, A; Bauer, C; Bauer, Th; Bay, A; Bediaga, I; Belogurov, S; Belous, K; Belyaev, I; Ben-Haim, E; Benayoun, M; Bencivenni, G; Benson, S; Benton, J; Bernet, R; Bettler, M-O; van Beuzekom, M; Bien, A; Bifani, S; Bird, T; Bizzeti, A; Bjørnstad, P M; Blake, T; Blanc, F; Blanks, C; Blouw, J; Blusk, S; Bobrov, A; Bocci, V; Bondar, A; Bondar, N; Bonivento, W; Borghi, S; Borgia, A; Bowcock, T J V; Bozzi, C; Brambach, T; van den Brand, J; Bressieux, J; Brett, D; Britsch, M; Britton, T; Brook, N H; Brown, H; Büchler-Germann, A; Burducea, I; Bursche, A; Buytaert, J; Cadeddu, S; Callot, O; Calvi, M; Calvo Gomez, M; Camboni, A; Campana, P; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carson, L; Carvalho Akiba, K; Casse, G; Cattaneo, M; Cauet, Ch; Charles, M; Charpentier, Ph; Chiapolini, N; Ciba, K; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Coca, C; Coco, V; Cogan, J; Collins, P; Comerma-Montells, A; Contu, A; Cook, A; Coombes, M; Corti, G; Couturier, B; Cowan, G A; Currie, R; D'Ambrosio, C; David, P; David, P N Y; De Bonis, I; De Bruyn, K; De Capua, S; De Cian, M; De Miranda, J M; De Paula, L; De Simone, P; Decamp, D; Deckenhoff, M; Degaudenzi, H; Del Buono, L; Deplano, C; Derkach, D; Deschamps, O; Dettori, F; Dickens, J; Dijkstra, H; Diniz Batista, P; Domingo Bonal, F; Donleavy, S; Dordei, F; Dosil Suárez, A; Dossett, D; Dovbnya, A; Dupertuis, F; Dzhelyadin, R; Dziurda, A; Easo, S; Egede, U; Egorychev, V; Eidelman, S; van Eijk, D; Eisele, F; Eisenhardt, S; Ekelhof, R; Eklund, L; Elsasser, Ch; Elsby, D; Esperante Pereira, D; Falabella, A; Färber, C; Fardell, G; Farinelli, C; Farry, S; Fave, V; Fernandez Albor, V; Ferro-Luzzi, M; Filippov, S; Fitzpatrick, C; Fontana, M; Fontanelli, F; Forty, R; Francisco, O; Frank, M; Frei, C; Frosini, M; Furcas, S; Gallas Torreira, A; Galli, D; Gandelman, M; Gandini, P; Gao, Y; Garnier, J-C; Garofoli, J; Garra Tico, J; Garrido, L; Gascon, D; Gaspar, C; Gauld, R; Gauvin, N; Gersabeck, M; Gershon, T; Ghez, Ph; Gibson, V; Gligorov, V V; Göbel, C; Golubkov, D; Golutvin, A; Gomes, A; Gordon, H; Grabalosa Gándara, M; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graziani, G; Grecu, A; Greening, E; Gregson, S; Gui, B; Gushchin, E; Guz, Yu; Gys, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hampson, T; Hansmann-Menzemer, S; Harji, R; Harnew, N; Harrison, J; Harrison, P F; Hartmann, T; He, J; Heijne, V; Hennessy, K; Henrard, P; Hernando Morata, J A; van Herwijnen, E; Hicks, E; Holubyev, K; Hopchev, P; Hulsbergen, W; Hunt, P; Huse, T; Huston, R S; Hutchcroft, D; Hynds, D; Iakovenko, V; Ilten, P; Imong, J; Jacobsson, R; Jaeger, A; Jahjah Hussein, M; Jans, E; Jansen, F; Jaton, P; Jean-Marie, B; Jing, F; John, M; Johnson, D; Jones, C R; Jost, B; Kaballo, M; Kandybei, S; Karacson, M; Karbach, T M; Keaveney, J; Kenyon, I R; Kerzel, U; Ketel, T; Keune, A; Khanji, B; Kim, Y M; Knecht, M; Koopman, R F; Koppenburg, P; Korolev, M; Kozlinskiy, A; Kravchuk, L; Kreplin, K; Kreps, M; Krocker, G; Krokovny, P; Kruse, F; Kruzelecki, K; Kucharczyk, M; Kudryavtsev, V; Kvaratskheliya, T; La Thi, V N; Lacarrere, D; Lafferty, G; Lai, A; Lambert, D; Lambert, R W; Lanciotti, E; Lanfranchi, G; Langenbruch, C; Latham, T; Lazzeroni, C; Le Gac, R; van Leerdam, J; Lees, J-P; Lefèvre, R; Leflat, A; Lefrançois, J; Leroy, O; Lesiak, T; Li, L; Li Gioi, L; Lieng, M; Liles, M; Lindner, R; Linn, C; Liu, B; Liu, G; von Loeben, J; Lopes, J H; Lopez Asamar, E; Lopez-March, N; Lu, H; Luisier, J; Mac Raighne, A; Machefert, F; Machikhiliyan, I V; Maciuc, F; Maev, O; Magnin, J; Malde, S; Mamunur, R M D; Manca, G; Mancinelli, G; Mangiafave, N; Marconi, U; Märki, R; Marks, J; Martellotti, G; Martens, A; Martin, L; Martín Sánchez, A; Martinelli, M; Martinez Santos, D; Massafferri, A; Mathe, Z; Matteuzzi, C; Matveev, M; Maurice, E; Maynard, B; Mazurov, A; McGregor, G; McNulty, R; Meissner, M; Merk, M; Merkel, J; Miglioranzi, S; Milanes, D A; Minard, M-N; Molina Rodriguez, J; Monteil, S; Moran, D; Morawski, P; Mountain, R; Mous, I; Muheim, F; Müller, K; Muresan, R; Muryn, B; Muster, B; Mylroie-Smith, J; Naik, P; Nakada, T; Nandakumar, R; Nasteva, I; Needham, M; Neufeld, N; Nguyen, A D; Nguyen-Mau, C; Nicol, M; Niess, V; Nikitin, N; Nikodem, T; Nomerotski, A; Novoselov, A; Oblakowska-Mucha, A; Obraztsov, V; Oggero, S; Ogilvy, S; Okhrimenko, O; Oldeman, R; Orlandea, M; Otalora Goicochea, J M; Owen, P; Pal, B K; Palacios, J; Palano, A; Palutan, M; Panman, J; Papanestis, A; Pappagallo, M; Parkes, C; Parkinson, C J; Passaleva, G; Patel, G D; Patel, M; Paterson, S K; Patrick, G N; Patrignani, C; Pavel-Nicorescu, C; Pazos Alvarez, A; Pellegrino, A; Penso, G; Pepe Altarelli, M; Perazzini, S; Perego, D L; Perez Trigo, E; Pérez-Calero Yzquierdo, A; Perret, P; Perrin-Terrin, M; Pessina, G; Petrolini, A; Phan, A; Picatoste Olloqui, E; Pie Valls, B; Pietrzyk, B; Pilař, T; Pinci, D; Plackett, R; Playfer, S; Plo Casasus, M; Polok, G; Poluektov, A; Polycarpo, E; Popov, D; Popovici, B; Potterat, C; Powell, A; Prisciandaro, J; Pugatch, V; Puig Navarro, A; Qian, W; Rademacker, J H; Rakotomiaramanana, B; Rangel, M S; Raniuk, I; Raven, G; Redford, S; Reid, M M; Dos Reis, A C; Ricciardi, S; Richards, A; Rinnert, K; Roa Romero, D A; Robbe, P; Rodrigues, E; Rodrigues, F; Rodriguez Perez, P; Rogers, G J; Roiser, S; Romanovsky, V; Rosello, M; Rouvinet, J; Ruf, T; Ruiz, H; Sabatino, G; Saborido Silva, J J; Sagidova, N; Sail, P; Saitta, B; Salzmann, C; Sannino, M; Santacesaria, R; Santamarina Rios, C; Santinelli, R; Santovetti, E; Sapunov, M; Sarti, A; Satriano, C; Satta, A; Savrie, M; Savrina, D; Schaack, P; Schiller, M; Schindler, H; Schleich, S; Schlupp, M; Schmelling, M; Schmidt, B; Schneider, O; Schopper, A; Schune, M-H; Schwemmer, R; Sciascia, B; Sciubba, A; Seco, M; Semennikov, A; Senderowska, K; Sepp, I; Serra, N; Serrano, J; Seyfert, P; Shapkin, M; Shapoval, I; Shatalov, P; Shcheglov, Y; Shears, T; Shekhtman, L; Shevchenko, O; Shevchenko, V; Shires, A; Silva Coutinho, R; Skwarnicki, T; Smith, N A; Smith, E; Sobczak, K; Soler, F J P; Solomin, A; Soomro, F; Souza De Paula, B; Spaan, B; Sparkes, A; Spradlin, P; Stagni, F; Stahl, S; Steinkamp, O; Stoica, S; Stone, S; Storaci, B; Straticiuc, M; Straumann, U; Subbiah, V K; Swientek, S; Szczekowski, M; Szczypka, P; Szumlak, T; T'jampens, S; Teodorescu, E; Teubert, F; Thomas, C; Thomas, E; van Tilburg, J; Tisserand, V; Tobin, M; Tolk, S; Topp-Joergensen, S; Torr, N; Tournefier, E; Tourneur, S; Tran, M T; Tsaregorodtsev, A; Tuning, N; Ubeda Garcia, M; Ukleja, A; Uwer, U; Vagnoni, V; Valenti, G; Vazquez Gomez, R; Vazquez Regueiro, P; Vecchi, S; Velthuis, J J; Veltri, M; Viaud, B; Videau, I; Vieira, D; Vilasis-Cardona, X; Visniakov, J; Vollhardt, A; Volyanskyy, D; Voong, D; Vorobyev, A; Vorobyev, V; Voss, H; Waldi, R; Wandernoth, S; Wang, J; Ward, D R; Watson, N K; Webber, A D; Websdale, D; Whitehead, M; Wiedner, D; Wiggers, L; Wilkinson, G; Williams, M P; Williams, M; Wilson, F F; Wishahi, J; Witek, M; Witzeling, W; Wotton, S A; Wyllie, K; Xie, Y; Xing, F; Xing, Z; Yang, Z; Young, R; Yushchenko, O; Zangoli, M; Zavertyaev, M; Zhang, F; Zhang, L; Zhang, W C; Zhang, Y; Zhelezov, A; Zhong, L; Zvyagin, A

    2012-06-22

    The decay B(c)(+) → J/ψπ(+) π(-) π(+) is observed for the first time, using 0.8 fb(-1) of pp collisions at sqrt[s] = 7 TeV collected by the LHCb experiment. The ratio of branching fractions B(B(c)(+) → J/ψπ(+) π(-) π(+))/B(B(c)(+)→J/ψπ^{+}) is measured to be 2.41 ± 0.30 ± 0.33, where the first uncertainty is statistical and the second is systematic. The result is in agreement with theoretical predictions. PMID:23004586

  1. The History of Medical Libraries from 2000 B.C. to 1900 A.D

    PubMed Central

    Birchette, Kathleen P.

    1973-01-01

    Tablets said to date back to 2000 b.c. represent the earliest medical writings so far discovered. The history of the medical library (defined as a place where a collection of medical writings is kept) is traced through ancient and medieval civilizations, and the dependence of advancement or decline on the attitude toward learning and knowledge is demonstrated. The change in structure of medical libraries that took place around the 1500s with the development of scientific societies is discussed. Medical libraries of Colonial America are described and the history is brought forward to the era of public library collections of medical material in the early 1900s. PMID:4579768

  2. Interaction of Jovian White Ovals BC and DE in 1998 from Earth-Based Observations in the Visual Range

    NASA Astrophysics Data System (ADS)

    Sánchez-Lavega, A.; Rojas, J. F.; Hueso, R.; Lecacheux, J.; Colas, F.; Acarreta, J. R.; Miyazaki, I.; Parker, D.

    1999-11-01

    During the 1998 Jupiter-Sun conjunction, the 60-year-old white ovals BC and DE at 33° south latitude merged into a larger oval "BE" at the same latitude (J. Lecacheux, P. Drossart, F. Colas, G. S. Orton, B. Fisher, A. Sanchez-Lavega, R. Hueso, J. F. Rojas, and I. Miyazaki, IAU Circular No. 6942). Here we report our study of the motions, morphology, and reflectivity changes pre and postmerger of the ovals based on extensive and continuous Earth-based CCD imaging (April 1997-September 1998) in the visual range (400-800 nm) and in the methane band at 890 nm. In late August 1997, BC and DE started their mutual approach with a relative zonal velocity of 1 m/s. The longitude drift curves of BC, DE, and new BE suggest that a merger of BC and DE took place in February 1998 in the position of BC. A smaller apparently cyclonic oval called O1 was seen in the northwest side of BE at latitude -31°. BE is about 12% larger than BC or DE as measured in the blue, red, and 890-nm methane band filters. However, if O1 is assumed to be a by-product of the merger, the sum of the areas of BC and DE is about that of BE and O1. The motion of BE is similar to that of the classic white oval spots. No significant center-to-limb reflectivity changes in the white oval spots at the 890-nm wavelength (sensitive to upper hazes and clouds) were noted before and after the merger. However the area-integrated blue-red color index changed slightly, with BE being bluer than BC or DE probably because the particles in BE have a higher single-scattering blue albedo. Using a radiative transfer model, the 890-nm data suggest that the upper cloud and haze (above 600 mbar) in BE are similar to those of BC and DE. In the limit, the upper cloud in BE could be higher (cloudtop at 110 mbar instead of 150 mbar) or have slightly larger optical depths (3.5 instead of 2.85) than that of BC or DE.

  3. The 21st century propulsion

    NASA Technical Reports Server (NTRS)

    Haloulakos, V. E.; Boehmer, C.

    1990-01-01

    The prediction of future space travel in the next millennium starts by examining the past and extrapolating into the far future. Goals for the 21st century include expanded space travel and establishment of permanent manned outposts, and representation of Lunar and Mars outposts as the most immediate future in space. Nuclear stage design/program considerations; launch considerations for manned Mars missions; and far future propulsion schemes are outlined.

  4. The 21st Century Skills Movement

    ERIC Educational Resources Information Center

    Johnson, Paige

    2009-01-01

    Since 2002, the Partnership for 21st Century Skills has been the leading advocacy organization in the United States focused on infusing 21st century skills into education. Its "Framework for 21st Century Learning," the result of a consensus among hundreds of stakeholders, describes the skills, knowledge, and expertise students need to succeed in…

  5. [The role of mental health in Greece from the 5th century B.C. to the end of the era].

    PubMed

    Dieckhöfer, K

    1982-12-01

    The article gives a survey of the psychohygienic ideas and conceptions appearing during this period, which were closely connected with a range of philosophical thoughts, by means of contemporary texts. From the epoch of the Greek comedy as reflection of the everyday-life of the Polis, Aristophanes has been quoted. The importance of the Epicurean philosophy and the spiritual guidance throughout the post-Epicurean stoa with its representatives Zenon, Chrysipp, Panaitios, Poseidonios and finally Epiktet, the latter being the most important representative of the fashionable philosophy during the Roman imperial reign, has been emphasised and analysed. The available sources show that eudaimonia, happiness, namely freedom from anxiety, menace and feelings of hatred, and furthermore the surveying of worldly wisdom, the control of one's impulses through Logos and education, harmony to compensate the contrasts, helpfulness towards one's fellow-men as well as the education of the individual to gain inner freedom, represent the most important antique directives of the mind in the sense of a rudimental psychohygiene and psychoprophylaxis. PMID:6187511

  6. CRF07_BC Strain Dominates the HIV-1 Epidemic in Injection Drug Users in Liangshan Prefecture of Sichuan, China.

    PubMed

    Li, Lin; Wei, Daying; Hsu, Wan-Ling; Li, Tianyi; Gui, Tao; Wood, Charles; Liu, Yongjian; Li, Hanping; Bao, Zuoyi; Liu, Siyang; Wang, Xiaolin; Li, Jingyun

    2015-05-01

    The Liangshan prefecture in Sichuan province is an area in China severely affected by the HIV epidemic, with intravenous drug use (IDU) as the main risk factor. No reports on HIV subtypes prevalent in IDUs in Liangshan prefecture could be found. In this study, we have characterized the genotypes of HIV-1 in the IDU population in Liangshan prefecture and further determined the phylogenetic relationship of the CRF07_BC strains to HIV-1 sequences from the other regions of China, including Xinjiang and Yunnan provinces, to explore the pattern and possible diffusion pathway of HIV-1 in these regions. HIV-1-seropositive drug-naive IDUs identified in Liangshan prefecture, Sichuan province were enrolled in 2009. Full-length gag and pol genes were amplified by reverse transcription and nested PCR and then sequenced. All of the sequences were subtyped. Phylogenetic trees were constructed using the neighbor-joining and maximum likelihood methods. Divergence times were estimated using a Bayesian molecular clock approach. CRF07_BC was found to be the predominant strain in IDUs in Liangshan prefecture (95.5%). The CRF07_BC strains from Liangshan prefecture were found to be intermixed with those from Yunnan province in phylogenetic trees. The CRF07_BC sequences from Xinjiang province can be grouped into several clusters, suggesting that the expansion of the CRF07_BC epidemic in Xinjiang province was the result of a local epidemic driven by multiple independent introductions in the late 1990s. Only low-level drug-resistant viruses were found in the IDU population. CRF07_BC strains from Liangshan prefecture were more similar to those from Yunnan province than those from Xinjiang province. This finding will contribute to our understanding of the distribution, the evolution, and the potential source of CRF07_BC founder strains, and will also provide useful information for the development of strategies to prevent transmission. PMID:25560398

  7. CRF07_BC Strain Dominates the HIV-1 Epidemic in Injection Drug Users in Liangshan Prefecture of Sichuan, China

    PubMed Central

    Li, Lin; Wei, Daying; Hsu, Wan-Ling; Li, Tianyi; Gui, Tao; Wood, Charles; Liu, Yongjian; Li, Hanping; Bao, Zuoyi; Liu, Siyang; Wang, Xiaolin

    2015-01-01

    Abstract The Liangshan prefecture in Sichuan province is an area in China severely affected by the HIV epidemic, with intravenous drug use (IDU) as the main risk factor. No reports on HIV subtypes prevalent in IDUs in Liangshan prefecture could be found. In this study, we have characterized the genotypes of HIV-1 in the IDU population in Liangshan prefecture and further determined the phylogenetic relationship of the CRF07_BC strains to HIV-1 sequences from the other regions of China, including Xinjiang and Yunnan provinces, to explore the pattern and possible diffusion pathway of HIV-1 in these regions. HIV-1-seropositive drug-naive IDUs identified in Liangshan prefecture, Sichuan province were enrolled in 2009. Full-length gag and pol genes were amplified by reverse transcription and nested PCR and then sequenced. All of the sequences were subtyped. Phylogenetic trees were constructed using the neighbor-joining and maximum likelihood methods. Divergence times were estimated using a Bayesian molecular clock approach. CRF07_BC was found to be the predominant strain in IDUs in Liangshan prefecture (95.5%). The CRF07_BC strains from Liangshan prefecture were found to be intermixed with those from Yunnan province in phylogenetic trees. The CRF07_BC sequences from Xinjiang province can be grouped into several clusters, suggesting that the expansion of the CRF07_BC epidemic in Xinjiang province was the result of a local epidemic driven by multiple independent introductions in the late 1990s. Only low-level drug-resistant viruses were found in the IDU population. CRF07_BC strains from Liangshan prefecture were more similar to those from Yunnan province than those from Xinjiang province. This finding will contribute to our understanding of the distribution, the evolution, and the potential source of CRF07_BC founder strains, and will also provide useful information for the development of strategies to prevent transmission. PMID:25560398

  8. Novel spin-electronic properties of BC{sub 7} sheets induced by strain

    SciTech Connect

    Xu, Lei; Dai, ZhenHong Sui, PengFei; Sun, YuMing; Wang, WeiTian

    2014-11-01

    Based on first-principles calculations, the authors have investigated the electronic and magnetic properties of BC{sub 7} sheets with different planar strains. It is found that metal–semiconductor transition appears at the biaxial strain of 15.5%, and the sheets are characteristic of spin-polarized semiconductor with a zero band-gap. The band-gap rapidly increases with strain, and reaches a maximum value of 0.60 eV at the strain of 20%. Subsequently, the band-gap decreases until the strain reaches up to 22% and shows a semiconductor-half metal transformation. It will further present metal properties until the strain is up to the maximum value of 35%. The magnetic moments also have some changes induced by biaxial strain. The numerical analysis shows that the two-dimensional distortions have great influences on the magnetic moments. The novel spin-electronic properties make BC{sub 7} sheets have potential applications in future spintronic nanodevices.

  9. Pertussis toxin treatment attenuates some effects of insulin in BC3H-1 murine myocytes

    SciTech Connect

    Luttrell, L.M.; Hewlett, E.L.; Romero, G.; Rogol, A.D.

    1988-05-05

    The effects of pertussis toxin (PT) treatment on insulin-stimulated myristoyl-diacylglycerol (DAG) generation, hexose transport, and thymidine incorporation were studied in differentiated BC3H-1 mycocytes. Insulin treatment caused a biphasic increase in myristoyl-DAG production which was abolished in myocytes treated with PT. There was no effect of PT treatment on basal (nonstimulated) myristoyl-DAG production. Insulin-stimulated hydrolysis of a membrane phosphatidylinositol glycan was blocked by PT treatment. ADP-ribosylation of BC3H-1 plasma membranes with (/sup 32/P)NAD revealed a 40-kDa protein as the major PT substrate in vivo and in vitro. The time course and dose dependence of the effects of PT on diacylglycerol generation correlated with the in vivo ADP-ribosylation of the 40-kDa substrate. Pertussis toxin treatment resulted in a 71% attenuation of insulin-stimulated hexose uptake without effect on either basal or phorbol ester-stimulated uptake. The stimulatory effects of insulin and fetal calf serum on (/sup 3/H)thymidine incorporation into quiescent myocytes were attenuated by 61 and 59%, respectively, when PT was added coincidently with the growth factors. Nonstimulated and EGF-stimulated (/sup 3/H)thymidine incorporation was unaffected by PT treatment. These data suggest that a PT-sensitive G protein is involved in the cellular signaling mechanisms of insulin.

  10. The archaeology of drill hole U20bc, Nevada Test Site, Nye County, Nevada

    SciTech Connect

    McLane, A.R.; Hemphill, M.L.; Livingston, S.J.; Pippin, L.C.; Walsh, L.A.

    1992-12-31

    Impacts to four sites near drill hole U20bc on Pahute Mesa in the northwestern part of the Nevada Test Site were mitigated through data recovery. The work was done during 1988 by the Desert Research Institute for the Department of Energy, Nevada Field Office (DOE/NV)- The four sites that warranted data recovery were 26NY3171, 26NY3173, 26NY5561 and 26NY5566. These sites had previously been determined eligible to the National Register of Historic Places. They were temporary camps that contained lithic debitage, projectile points, milling stones and pottery, and therefore contributed significant information concerning the prehistory of the area. The study of the archaeological remains shows that the prehistoric people subsisted on plant foods and game animals as determined by the artifacts including manos, metates, pottery, lithic scrapers, and projectile points. The time sensitive arfifacts (pottery and diagnostic points) suggest that the region was used from about 12,000 B.P. to just before the historic period, possibly 150 years ago. DOE/NV has met its obligation to mitigate adverse impacts to the cultural resources at U20bc. Therefore, it is recommended that this project proceed as planned.

  11. The archaeology of drill hole U20bc, Nevada Test Site, Nye County, Nevada

    SciTech Connect

    McLane, A.R.; Hemphill, M.L.; Livingston, S.J.; Pippin, L.C.; Walsh, L.A.

    1992-01-01

    Impacts to four sites near drill hole U20bc on Pahute Mesa in the northwestern part of the Nevada Test Site were mitigated through data recovery. The work was done during 1988 by the Desert Research Institute for the Department of Energy, Nevada Field Office (DOE/NV)- The four sites that warranted data recovery were 26NY3171, 26NY3173, 26NY5561 and 26NY5566. These sites had previously been determined eligible to the National Register of Historic Places. They were temporary camps that contained lithic debitage, projectile points, milling stones and pottery, and therefore contributed significant information concerning the prehistory of the area. The study of the archaeological remains shows that the prehistoric people subsisted on plant foods and game animals as determined by the artifacts including manos, metates, pottery, lithic scrapers, and projectile points. The time sensitive arfifacts (pottery and diagnostic points) suggest that the region was used from about 12,000 B.P. to just before the historic period, possibly 150 years ago. DOE/NV has met its obligation to mitigate adverse impacts to the cultural resources at U20bc. Therefore, it is recommended that this project proceed as planned.

  12. Translocation step size and mechanism of the RecBC DNA helicase.

    PubMed

    Bianco, P R; Kowalczykowski, S C

    2000-05-18

    DNA helicases are ubiquitous enzymes that unwind double-stranded DNA. They are a diverse group of proteins that move in a linear fashion along a one-dimensional polymer lattice--DNA--by using a mechanism that couples nucleoside triphosphate hydrolysis to both translocation and double-stranded DNA unwinding to produce separate strands of DNA. The RecBC enzyme is a processive DNA helicase that functions in homologous recombination in Escherichia coli; it unwinds up to 6,250 base pairs per binding event and hydrolyses slightly more than one ATP molecule per base pair unwound. Here we show, by using a series of gapped oligonucleotide substrates, that this enzyme translocates along only one strand of duplex DNA in the 3'-->5' direction. The translocating enzyme will traverse, or 'step' across, single-stranded DNA gaps in defined steps that are 23 (+/-2) nucleotides in length. This step is much larger than the amount of double-stranded DNA that can be unwound using the free energy derived from hydrolysis of one molecule of ATP, implying that translocation and DNA unwinding are separate events. We propose that the RecBC enzyme both translocates and unwinds by a quantized, two-step, inchworm-like mechanism that may have parallels for translocation by other linear motor proteins. PMID:10830968

  13. Regulatory interactions in the dimeric cytochrome bc1 complex: The advantages of being a twin

    PubMed Central

    Covian, Raul; Trumpower, Bernard L.

    2008-01-01

    The dimeric cytochrome bc1 complex catalyzes the oxidation-reduction of quinol and quinone at sites located in opposite sides of the membrane in which it resides. We review the kinetics of electron transfer and inhibitor binding that reveal functional interactions between the quinol oxidation site at center P and quinone reduction site at center N in opposite monomers in conjunction with electron equilibration between the cytochrome b subunits of the dimer. A model for the mechanism of the bc1 complex has emerged from these studies in which binding of ligands that mimic semiquinone at center N regulates half-of-the-sites reactivity at center P and binding of ligands that mimic catalytically competent binding of ubiquinol at center P regulates half-of-the-sites reactivity at center N. An additional feature of this model is that inhibition of quinol oxidation at the quinone reduction site is avoided by allowing catalysis in only one monomer at a time, which maximizes the number of redox acceptor centers available in cytochrome b for electrons coming from quinol oxidation reactions at center P and minimizes the leakage of electrons that would result in the generation of damaging oxygen radicals. PMID:18471987

  14. Molecular characterization of the gene for human interleukin-1[beta] converting enzyme (IL1BC)

    SciTech Connect

    Cerretti, D.P.; Hollingsworth, L.T.; Kozlosky, C.J.; Nelson, N. ); Valentine, M.B. ); Shapiro, D.N.; Morris, S.W. Univ. of Tennessee College of Medicine, Memphis, TN )

    1994-04-01

    Interleukin-1[beta] (IL-1[beta]) mediates a wide range of immune and inflammatory responses. The active cytokine is generated by proteolytic cleavage of an inactive precursor by a protease called the IL-1[beta] converting enzyme (ICE). A cDNA encoding this protease was recently isolated. A human genomic clone containing the ICE gene (IL1BC) was isolated using the cDNA as a probe. The gene consists of 10 exons spanning at least 10.6 kb. 5[prime]-anchored polymerase chain reaction indicated a single transcription start site [approximately]33 bp upstream of the initiator Met codon. The 5[prime]-flanking region does not have an apparent TATA box but may contain an initiator (Inr) promotor element. However, transcriptional activity could not be detected with a fusion gene containing the 5[prime]-flanking region linked to the bacterial chloramphenicol acetyltransferase gene (CAT) when transfected into the human acute monocytic leukemia cell line THP-1. Using the genomic IL1BC clone, the authors have confirmed the localization of the gene to chromosome 11 band q22.2-q22.3 by fluorescence in situ hybridization. 34 refs., 2 figs., 1 tab.

  15. Engineered Mononuclear Variants in Bacillus cereus Metallo-β-lactamase BcII Are Inactive†

    PubMed Central

    Abriata, Luciano A.; González, Lisandro J.; Llarrull, Leticia I.; Tomatis, Pablo E.; Myers, William K.; Costello, Alison L.; Tierney, David L.; Vila, Alejandro J.

    2008-01-01

    Metallo-β-lactamases (MβLs) are zinc enzymes able to hydrolyze almost all β-lactam antibiotics, rendering them inactive, at the same time endowing bacteria high levels of resistance. The design of inhibitors active against all classes of MβLs has been hampered by their structural diversity and by the heterogeneity in metal content in enzymes from different sources. BcII is the metallo-β-lactamase from Bacillus cereus, which is found in both the mononuclear and dinuclear forms. Despite extensive studies, there is still controversy about the nature of the active BcII species. Here we have designed two mutant enzymes in which each one of the metal binding sites was selectively removed. Both mutants were almost inactive, despite preserving most of the structural features of each metal site. These results reveal that neither site isolated in the MβL scaffold is sufficient to render a fully active enzyme. This suggests that only the dinuclear species is active or that the mononuclear variants can be active only if aided by other residues that would be metal ligands in the dinuclear species. PMID:18652482

  16. Thermal evolution of the metastable r8 and bc8 polymorphs of silicon

    SciTech Connect

    Haberl, Bianca; Guthrie, Malcolm; Sinogeikin, Stanislav V.; Shen, Guoyin; Williams, James S.; Bradby, Jodie E.

    2015-01-28

    The kinetics of two metastable polymorphs of silicon under thermal annealing was investigated. These phases with body-centered cubic bc8 and rhombohedral r8 structures can be formed upon pressure release from metallic silicon.We study these metastable polymorphs were formed by two different methods, via point loading and in a diamond anvil cell (DAC). Upon thermal annealing different transition pathways were detected. In the point loading case, the previously reported Si-XIII formed and was confirmed as a new phase with an as-yet-unidentified structure. In the DAC case, bc8-Si transformed to the hexagonal-diamond structure at elevated pressure, consistent with previous studies at ambient pressure. In contrast, r8-Si transformed directly to diamond-cubic Si at a temperature of 255⁰C. In conclusion, these data were used to construct diagrams of the metastability regimes of the polymorphs formed in a DAC and may prove useful for potential technological applications of these metastable polymorphs.

  17. Thermal evolution of the metastable r8 and bc8 polymorphs of silicon

    DOE PAGESBeta

    Haberl, Bianca; Guthrie, Malcolm; Sinogeikin, Stanislav V.; Shen, Guoyin; Williams, James S.; Bradby, Jodie E.

    2015-01-28

    The kinetics of two metastable polymorphs of silicon under thermal annealing was investigated. These phases with body-centered cubic bc8 and rhombohedral r8 structures can be formed upon pressure release from metallic silicon.We study these metastable polymorphs were formed by two different methods, via point loading and in a diamond anvil cell (DAC). Upon thermal annealing different transition pathways were detected. In the point loading case, the previously reported Si-XIII formed and was confirmed as a new phase with an as-yet-unidentified structure. In the DAC case, bc8-Si transformed to the hexagonal-diamond structure at elevated pressure, consistent with previous studies at ambientmore » pressure. In contrast, r8-Si transformed directly to diamond-cubic Si at a temperature of 255⁰C. In conclusion, these data were used to construct diagrams of the metastability regimes of the polymorphs formed in a DAC and may prove useful for potential technological applications of these metastable polymorphs.« less

  18. Release of arachidonic acid from oligodendrocytes by terminal complement proteins, C5b-C9

    SciTech Connect

    Shirazi, Y.; Imagawa, D.K.; Shin, M.L.

    1986-03-01

    Activation of C5b-C9 on monocytes, macrophages, platelets and neutrophils induces membrane lipid hydrolysis and generates arachidonic acid (AA) and its oxygenated derivatives. Additionally, activation of C5b-C9 and myelin lipid hydrolysis has been observed in demyelination. The authors have investigated the modulatory effect of C5b-9 on membrane lipid hydrolysis of oligodendrocytes (OLG), the myelin producing cells in the central nervous system. Antibody-sensitized rat OLG, prelabeled with /sup 14/C AA were treated with excess C6-deficient rabbit serum reconstituted with limiting doses of C6. Qualitative analysis of the supernatants by HPLC revealed the presence of both cyclooxygenase and lipooxygenase products. Prostaglandin E/sub 2/, leukotriene (LT) E/sub 4/, LTB/sub 4/ and free AA were the major radiolabeled products. The kinetics and dose response of LTB/sub 4/ release with respect to the cytolytic dose of C5b-9 were quantitated by radioimmunoassay. LTB/sub 4/ release approached maximum in 1 hr and higher amounts were detected with fewer C5b-9 channels. Addition of C8 to OLG bearing C5b-7 intermediates induced maximum LTB/sub 4/ release without further enhancement by C9 in contrast to the absolute requirement of C9 in mediator release from rat neutrophils. Thus, the requirement of C5b-8 or C5b-9 in mediator release appears to be cell-type dependent.

  19. Molecular Modeling Analysis of the Inhibition of Mitochondrial Cytochrome BC1 Complex Activity by Tocol Derivatives

    NASA Astrophysics Data System (ADS)

    Singh, Awantika; Hauer-Jensen, Martin; Compadre, Cesar M.; Kumar, K. Sree

    2011-06-01

    The biological functions of vitamin E related compounds have been of interest in biomedical research for several decades. Among those compounds, α-, β-, δ-, and γ-tocopherols and their oxidation products, α-, β-, δ-, γ-tocopherylquinone and their analogs α-TQo, γ-TQo, TMC20 and TMC40 were recently shown to inhibit the mitochondrial cytochrome bc1 complex. In this investigation the effects of the structural variation on the inhibition of the mitochondrial cytochrome bc1 complex were analyzed using Comparative Molecular Field Analysis (CoMFA). CoMFA performed using steric and electrostatic molecular fields produced a very good correlation. The best CoMFA models were obtained using the manual alignment of 12 compounds with 5 components (q2 = 0.589, SPRESS = 0.515, r2 = 0.992, s = 0.068 and F value = 156.520). The resulting contour maps produced by the best CoMFA model were helpful in identifying the structural features required for the biological activity of compounds under study. These results would be helpful for predicting the activity of new compounds, and they could be used for guiding the design, synthesis and development of new and more effective agents.

  20. Early (300-100 B.C.) temple precinct in the Valley of Oaxaca, Mexico.

    PubMed

    Redmond, Elsa M; Spencer, Charles S

    2013-05-01

    Archaeological investigations during the past two decades in Mexico's Valley of Oaxaca have documented the appearance of key public buildings, such as the royal palace and multiroom temple, associated with the rise of an archaic state at ca. 300-100 B.C. A fuller picture is now emerging from the site of El Palenque, where recent excavations have defined a temple precinct on the east side of the site's plaza. This precinct exhibits characteristics similar to those of the temple precincts of later Mesoamerican states described by Colonial period sources. The excavation data document a walled enclosure containing three multiroom temples, two special residences identified as priests' residences, and an array of ritual features and activity areas. The temple precinct's components are interpreted as comprising a hierarchy of temples staffed by a specialized priesthood. A series of radiocarbon dates indicate that the precinct's differentiated components were all in use during the 300-100 B.C. period of archaic state emergence. The El Palenque temple precinct is the earliest temple precinct excavated thus far in the Valley of Oaxaca. PMID:23610387

  1. Vertical profiles of BC direct radiative effect over Italy: high vertical resolution data and atmospheric feedbacks

    NASA Astrophysics Data System (ADS)

    Močnik, Griša; Ferrero, Luca; Castelli, Mariapina; Ferrini, Barbara S.; Moscatelli, Marco; Grazia Perrone, Maria; Sangiorgi, Giorgia; Rovelli, Grazia; D'Angelo, Luca; Moroni, Beatrice; Scardazza, Francesco; Bolzacchini, Ezio; Petitta, Marcello; Cappelletti, David

    2016-04-01

    Black carbon (BC), and its vertical distribution, affects the climate. Global measurements of BC vertical profiles are lacking to support climate change research. To fill this gap, a campaign was conducted over three Italian basin valleys, Terni Valley (Appennines), Po Valley and Passiria Valley (Alps), to characterize the impact of BC on the radiative budget under similar orographic conditions. 120 vertical profiles were measured in winter 2010. The BC vertical profiles, together with aerosol size distribution, aerosol chemistry and meteorological parameters, have been determined using a tethered balloon-based platform equipped with: a micro-Aethalometer AE51 (Magee Scientific), a 1.107 Grimm OPC (0.25-32 μm, 31 size classes), a cascade impactor (Siuotas SKC), and a meteorological station (LSI-Lastem). The aerosol chemical composition was determined from collected PM2.5 samples. The aerosol absorption along the vertical profiles was measured and optical properties calculated using the Mie theory applied to the aerosol size distribution. The aerosol optical properties were validated with AERONET data and then used as inputs to the radiative transfer model libRadtran. Vertical profiles of the aerosol direct radiative effect, the related atmospheric absorption and the heating rate were calculated. Vertical profile measurements revealed some common behaviors over the studied basin valleys. From below the mixing height to above it, a marked concentration drop was found for both BC (from -48.4±5.3% up to -69.1±5.5%) and aerosol number concentration (from -23.9±4.3% up to -46.5±7.3%). These features reflected on the optical properties of the aerosol. Absorption and scattering coefficients decreased from below the MH to above it (babs from -47.6±2.5% up to -71.3±3.0% and bsca from -23.5±0.8% up to -61.2±3.1%, respectively). Consequently, the Single Scattering Albedo increased above the MH (from +4.9±2.2% to +7.4±1.0%). The highest aerosol absorption was

  2. Black carbon over Mexico: The effect of atmospheric transport on mixing state, mass absorption cross-section, and BC/CO ratios

    SciTech Connect

    Subramanian, R.; Kok, G. L.; Baumgardner, Darrel; Clarke, A. D.; Shinozuka, Y.; Campos, Teresa; Heizer, CG; Stephens, Britton; de Foy, B.; Voss, Paul B.; Zaveri, Rahul A.

    2010-01-13

    A single particle soot photometer (SP2) was operated on the NCAR C-130 during the MIRAGE campaign (part of MILAGRO), sampling black carbon (BC) over Mexico. The highest BC concentrations were measured over Mexico City (sometimes as much as 2 Fg/m34 ) and over hill fires to the south of the city. The age of plumes outside of Mexico City was determined using a combination of HYSPLIT trajectories, WRF-FLEXPART modeling and CMET balloon tracks. As expected, older, diluted air masses had lower BC concentrations. A comparison of carbon monoxide (CO) and BC suggests a CO background of around 65 ppbv, and a backgroundcorrected BC/COnet ratio of 2.89±0.89 (ng/m39 -STP)/ppbv (average ± standard deviation). This ratio is similar for fresh emissions over Mexico City, as well as for aged airmasses. Comparison of light absorption measured with a particle soot absorption photometer (PSAP) and the SP2 BC suggests a BC mass-normalized absorption cross-section (MAC) of 10.9±2.1 m212 /g at 660 nm (or 13.1 m213 /g @ 550 nm, assuming MAC is inversely dependent on wavelength). This appears independent of aging and similar to the expected absorption cross-section for aged BC, but values, particularly in fresh emissions, could be biased high due to instrument artifacts. SP2-derived BC coating indicators show a prominent thinly-coated BC mode over the Mexico City Metropolitan Area (MCMA), while older air masses show both thinly-coated and thickly-coated BC. Some 2-day-old plumes do not show a prominent thickly-coated BC mode, possibly due to preferential wet scavenging of the likely-hydrophilic thickly-coated BC.

  3. MicroRNA-34b/c suppresses uveal melanoma cell proliferation and migration through multiple targets

    PubMed Central

    Dong, Feng

    2012-01-01

    Purpose MicroRNAs (miRNAs) are endogenously expressed, small noncoding RNAs that inhibit gene expression by binding to target mRNAs. Recent studies have revealed that miRNAs function as tumor suppressors or oncogenes. In the present study, we investigated the role of miRNA-34b/c in uveal melanoma. Methods Real-time reverse transcriptase polymerase chain reaction (RT-PCR) was performed to detect the expression level of miR-34b/c in uveal melanoma cells and primary samples. Subsequently, uveal melanoma cell proliferation was examined by the MTS (3-[4,5-dimethylthiazol-2-yl]-5-[3-carboxymethoxyphenyl]-2-[4-sulfophenyl] -2H-tetrazolium, inner salt) assay, clone formation assay, and flow cytometry. Cell apoptosis was measured by caspase3/7 assay. Cell migration was evaluated by transwell migration assay. The target of miR-34b/c was predicted by bioinformatics and validated by luciferase assay. In addition, the effect of miR-34b/c on c-Met, cell cycle-related proteins, v-akt murine thymoma viral oncogene homolog (Akt) and extracellular signal-regulated kinase (ERK) pathway was determined by western blotting. Results miR-34b/c expression, which was dramatically decreased in uveal melanoma cells and clinical samples, can be upregulated by doxorubicin and epigenetic drugs. The transfection of miR-34b/c into uveal melanoma cells leads to a significant reduction in cell growth and migration. miR-34b/c caused cell cycle G1 arrest rather than the induction of apoptosis. Met proto-oncogene (c-Met) was identified as a target of miR-34b/c in uveal melanoma cells. Furthermore, miR-34b/c was confirmed to downregulate the expression of c-Met, p-Akt, and cell cycle–related proteins by western blotting. Conclusions Our results demonstrate that both miR-34b and miR-34c act as tumor suppressors in uveal melanoma cell proliferation and migration through the downregulation of multiple targets. PMID:22419847

  4. Differences between magnitudes and health impacts of BC emissions across the United States using 12 km scale seasonal source apportionment.

    PubMed

    Turner, Matthew D; Henze, Daven K; Hakami, Amir; Zhao, Shunliu; Resler, Jaroslav; Carmichael, Gregory R; Stanier, Charles O; Baek, Jaemeen; Sandu, Adrian; Russell, Armistead G; Nenes, Athanasios; Jeong, Gill-Ran; Capps, Shannon L; Percell, Peter B; Pinder, Rob W; Napelenok, Sergey L; Bash, Jesse O; Chai, Tianfeng

    2015-04-01

    Recent assessments have analyzed the health impacts of PM2.5 from emissions from different locations and sectors using simplified or reduced-form air quality models. Here we present an alternative approach using the adjoint of the Community Multiscale Air Quality (CMAQ) model, which provides source-receptor relationships at highly resolved sectoral, spatial, and temporal scales. While damage resulting from anthropogenic emissions of BC is strongly correlated with population and premature death, we found little correlation between damage and emission magnitude, suggesting that controls on the largest emissions may not be the most efficient means of reducing damage resulting from anthropogenic BC emissions. Rather, the best proxy for locations with damaging BC emissions is locations where premature deaths occur. Onroad diesel and nonroad vehicle emissions are the largest contributors to premature deaths attributed to exposure to BC, while onroad gasoline emissions cause the highest deaths per amount emitted. Emissions in fall and winter contribute to more premature deaths (and more per amount emitted) than emissions in spring and summer. Overall, these results show the value of the high-resolution source attribution for determining the locations, seasons, and sectors for which BC emission controls have the most effective health benefits. PMID:25729920

  5. Australian human and parrot Chlamydia psittaci strains cluster within the highly virulent 6BC clade of this important zoonotic pathogen

    PubMed Central

    Branley, James; Bachmann, Nathan L.; Jelocnik, Martina; Myers, Garry S. A.; Polkinghorne, Adam

    2016-01-01

    Chlamydia psittaci is an avian pathogen and zoonotic agent of atypical pneumonia. The most pathogenic C. psittaci strains cluster into the 6BC clade, predicted to have recently emerged globally. Exposure to infected parrots is a risk factor with limited evidence also of an indirect exposure risk. Genome sequencing was performed on six Australian human and a single avian C. psittaci strain isolated over a 9 year period. Only one of the five human patients had explicit psittacine contact. Genomics analyses revealed that the Australian C. psittaci strains are remarkably similar, clustering tightly within the C. psittaci 6BC clade suggested to have been disseminated by South America parrot importation. Molecular clock analysis using the newly sequenced C. psittaci genomes predicted the emergence of the 6BC clade occurring approximately 2,000 years ago. These findings reveal the potential for an Australian natural reservoir of C. psittaci 6BC strains. These strains can also be isolated from seriously ill patients without explicit psittacine contact. The apparent recent and global spread of C. psittaci 6BC strains raises important questions over how this happened. Further studies may reveal whether the dissemination of this important zoonotic pathogen is linked to Australian parrot importation rather than parrots from elsewhere. PMID:27488134

  6. Australian human and parrot Chlamydia psittaci strains cluster within the highly virulent 6BC clade of this important zoonotic pathogen.

    PubMed

    Branley, James; Bachmann, Nathan L; Jelocnik, Martina; Myers, Garry S A; Polkinghorne, Adam

    2016-01-01

    Chlamydia psittaci is an avian pathogen and zoonotic agent of atypical pneumonia. The most pathogenic C. psittaci strains cluster into the 6BC clade, predicted to have recently emerged globally. Exposure to infected parrots is a risk factor with limited evidence also of an indirect exposure risk. Genome sequencing was performed on six Australian human and a single avian C. psittaci strain isolated over a 9 year period. Only one of the five human patients had explicit psittacine contact. Genomics analyses revealed that the Australian C. psittaci strains are remarkably similar, clustering tightly within the C. psittaci 6BC clade suggested to have been disseminated by South America parrot importation. Molecular clock analysis using the newly sequenced C. psittaci genomes predicted the emergence of the 6BC clade occurring approximately 2,000 years ago. These findings reveal the potential for an Australian natural reservoir of C. psittaci 6BC strains. These strains can also be isolated from seriously ill patients without explicit psittacine contact. The apparent recent and global spread of C. psittaci 6BC strains raises important questions over how this happened. Further studies may reveal whether the dissemination of this important zoonotic pathogen is linked to Australian parrot importation rather than parrots from elsewhere. PMID:27488134

  7. Canada's Fraser River Basin transitioning from a nival to a hybrid system in the late 20th century

    NASA Astrophysics Data System (ADS)

    Kang, D. H.; Gao, H.; Shi, X.; Dery, S. J.

    2014-12-01

    The Fraser River Basin (FRB) is the largest river draining to the Pacific Ocean in British Columbia (BC), Canada, and it provides the world's most abundant salmon populations. With recent climate change, the shifting hydrologic regime of the FRB is evaluated using hydrological modeling results over the period 1949 to 2006. To quantify the contribution of snowmelt to runoff generation, the ratio RSR, defined as the division of the sum of the snowmelt across the watershed by the integrated runoff over the water year, is employed. Modeled results for RSR at Hope, BC — the furthest downstream hydrometric station of the FRB — show a significant decrease (from 0.80 to 0.65) in the latter part of the 20th century. RSR is found to be mainly suppressed by a decrease of the snowmelt across the FRB with a decline with 107 mm by 26 % along the simulation period. There is also a prominent shift in the timing of streamflow, with the spring freshet at Hope, BC advancing 30 days followed by reduced summer flows for over two months. The timing of the peak spring freshet becomes even earlier when moving upstream of the FRB owing to short periods of time after melting from the snow source to the rivers.

  8. The Architecture of the Qo Site of Cytochrome bc1 Complex Probed by Superoxide Production

    SciTech Connect

    Muller, Florian L.; Roberts, Arthur G.; Bowman, Michael K.); Kramer, David M.

    2003-06-03

    Although several X-ray structures have been solved for the mitochondrial cytochrome (cyt) bc1 complex, none yet shows the position of substrate, ubiquinol, in the quinol oxidase (Qo) site. In the present study, the interaction of molecular oxygen with the reactive intermediate Qo semiquinone is used to probe Qo site. It has been known for some time that partial turnover of the cyt bc1 complex in the presence of antimycin A, a Qi site inhibitor, results in accumulation of a semiquinone at the Qo site, which can reduce O2 to superoxide (O2?-). It was more recently shown that myxothiazol, which binds close to the cyt bL heme in the proximal Qo niche, also induces O2?- production. In this work we show that, in addition to myxothiazol, a number of other proximal Qo inhibitors (including E-b-methoxyacrylate-stilbene, mucidin and famoxadone) also induce O2?- production in isolated yeast cyt bc1 complex, at about 50% the Vmax observed in the presence of antimycin A. We propose that proximal Qo site inhibitors induce O2?- production because they allow formation, but not oxidation of the semiquinone at the distal niche of the Qo site pocket. The apparent Km for ubiquinol at the Qo site in the presence of Qo proximal inhibitors suggests that the distal niche of the Qo pocket can act as a fully independent quinol binding and oxidation site. Together with the X-ray structures these results suggest substrate ubiquinol binds in essentially the same position as stigmatellin with H-bonds between H161 of the Rieske iron-sulfur protein and E272 of the cyt b protein. When modeled in this way, mucidin, and ubiquinol can bind simultaneously to the Qo site with virtually no steric hindrance, whereas progressively bulkier inhibitors show increasing overlap. The fact that partial turnover of the Qo site is possible even with bound proximal Qo site inhibitors is consistent with the participation of two separate functional Qo binding niches, occupied simultaneously or sequentially.

  9. Study of the B_c^+ → J/ψ D_s^+ and B_c^+ → J/ψ D_s^{*+} decays with the ATLAS detector

    NASA Astrophysics Data System (ADS)

    Aad, G.; Abbott, B.; Abdallah, J.; Abdinov, O.; Aben, R.; Abolins, M.; AbouZeid, O. S.; Abramowicz, H.; Abreu, H.; Abreu, R.; Abulaiti, Y.; Acharya, B. S.; Adamczyk, L.; Adams, D. L.; Adelman, J.; Adomeit, S.; Adye, T.; Affolder, A. A.; Agatonovic-Jovin, T.; Aguilar-Saavedra, J. A.; Ahlen, S. P.; Ahmadov, F.; Aielli, G.; Akerstedt, H.; Åkesson, T. P. A.; Akimoto, G.; Akimov, A. V.; Alberghi, G. L.; Albert, J.; Albrand, S.; Alconada Verzini, M. J.; Aleksa, M.; Aleksandrov, I. N.; Alexa, C.; Alexander, G.; Alexopoulos, T.; Alhroob, M.; Alimonti, G.; Alio, L.; Alison, J.; Alkire, S. P.; Allbrooke, B. M. M.; Allport, P. P.; Aloisio, A.; Alonso, A.; Alonso, F.; Alpigiani, C.; Altheimer, A.; Alvarez Gonzalez, B.; Álvarez Piqueras, D.; Alviggi, M. G.; Amadio, B. T.; Amako, K.; Amaral Coutinho, Y.; Amelung, C.; Amidei, D.; Amor Dos Santos, S. P.; Amorim, A.; Amoroso, S.; Amram, N.; Amundsen, G.; Anastopoulos, C.; Ancu, L. S.; Andari, N.; Andeen, T.; Anders, C. F.; Anders, G.; Anders, J. K.; Anderson, K. J.; Andreazza, A.; Andrei, V.; Angelidakis, S.; Angelozzi, I.; Anger, P.; Angerami, A.; Anghinolfi, F.; Anisenkov, A. V.; Anjos, N.; Annovi, A.; Antonelli, M.; Antonov, A.; Antos, J.; Anulli, F.; Aoki, M.; Aperio Bella, L.; Arabidze, G.; Arai, Y.; Araque, J. P.; Arce, A. T. H.; Arduh, F. A.; Arguin, J.-F.; Argyropoulos, S.; Arik, M.; Armbruster, A. J.; Arnaez, O.; Arnal, V.; Arnold, H.; Arratia, M.; Arslan, O.; Artamonov, A.; Artoni, G.; Asai, S.; Asbah, N.; Ashkenazi, A.; Åsman, B.; Asquith, L.; Assamagan, K.; Astalos, R.; Atkinson, M.; Atlay, N. B.; Auerbach, B.; Augsten, K.; Aurousseau, M.; Avolio, G.; Axen, B.; Ayoub, M. K.; Azuelos, G.; Baak, M. A.; Baas, A. E.; Bacci, C.; Bachacou, H.; Bachas, K.; Backes, M.; Backhaus, M.; Bagiacchi, P.; Bagnaia, P.; Bai, Y.; Bain, T.; Baines, J. T.; Baker, O. K.; Balek, P.; Balestri, T.; Balli, F.; Banas, E.; Banerjee, Sw.; Bannoura, A. A. E.; Bansil, H. S.; Barak, L.; Barberio, E. L.; Barberis, D.; Barbero, M.; Barillari, T.; Barisonzi, M.; Barklow, T.; Barlow, N.; Barnes, S. L.; Barnett, B. M.; Barnett, R. M.; Barnovska, Z.; Baroncelli, A.; Barone, G.; Barr, A. J.; Barreiro, F.; Barreiro Guimarães da Costa, J.; Bartoldus, R.; Barton, A. E.; Bartos, P.; Basalaev, A.; Bassalat, A.; Basye, A.; Bates, R. L.; Batista, S. J.; Batley, J. R.; Battaglia, M.; Bauce, M.; Bauer, F.; Bawa, H. S.; Beacham, J. B.; Beattie, M. D.; Beau, T.; Beauchemin, P. H.; Beccherle, R.; Bechtle, P.; Beck, H. P.; Becker, K.; Becker, M.; Becker, S.; Beckingham, M.; Becot, C.; Beddall, A. J.; Beddall, A.; Bednyakov, V. A.; Bee, C. P.; Beemster, L. J.; Beermann, T. A.; Begel, M.; Behr, J. K.; Belanger-Champagne, C.; Bell, W. H.; Bella, G.; Bellagamba, L.; Bellerive, A.; Bellomo, M.; Belotskiy, K.; Beltramello, O.; Benary, O.; Benchekroun, D.; Bender, M.; Bendtz, K.; Benekos, N.; Benhammou, Y.; Benhar Noccioli, E.; Benitez Garcia, J. A.; Benjamin, D. P.; Bensinger, J. R.; Bentvelsen, S.; Beresford, L.; Beretta, M.; Berge, D.; Bergeaas Kuutmann, E.; Berger, N.; Berghaus, F.; Beringer, J.; Bernard, C.; Bernard, N. R.; Bernius, C.; Bernlochner, F. U.; Berry, T.; Berta, P.; Bertella, C.; Bertoli, G.; Bertolucci, F.; Bertsche, C.; Bertsche, D.; Besana, M. I.; Besjes, G. J.; Bessidskaia Bylund, O.; Bessner, M.; Besson, N.; Betancourt, C.; Bethke, S.; Bevan, A. J.; Bhimji, W.; Bianchi, R. M.; Bianchini, L.; Bianco, M.; Biebel, O.; Bieniek, S. P.; Biglietti, M.; Bilbao De Mendizabal, J.; Bilokon, H.; Bindi, M.; Binet, S.; Bingul, A.; Bini, C.; Black, C. W.; Black, J. E.; Black, K. M.; Blackburn, D.; Blair, R. E.; Blanchard, J.-B.; Blanco, J. E.; Blazek, T.; Bloch, I.; Blocker, C.; Blum, W.; Blumenschein, U.; Bobbink, G. J.; Bobrovnikov, V. S.; Bocchetta, S. S.; Bocci, A.; Bock, C.; Boehler, M.; Bogaerts, J. A.; Bogavac, D.; Bogdanchikov, A. G.; Bohm, C.; Boisvert, V.; Bold, T.; Boldea, V.; Boldyrev, A. S.; Bomben, M.; Bona, M.; Boonekamp, M.; Borisov, A.; Borissov, G.; Borroni, S.; Bortfeldt, J.; Bortolotto, V.; Bos, K.; Boscherini, D.; Bosman, M.; Boudreau, J.; Bouffard, J.; Bouhova-Thacker, E. V.; Boumediene, D.; Bourdarios, C.; Bousson, N.; Boveia, A.; Boyd, J.; Boyko, I. R.; Bozic, I.; Bracinik, J.; Brandt, A.; Brandt, G.; Brandt, O.; Bratzler, U.; Brau, B.; Brau, J. E.; Braun, H. M.; Brazzale, S. F.; Breaden Madden, W. D.; Brendlinger, K.; Brennan, A. J.; Brenner, L.; Brenner, R.; Bressler, S.; Bristow, K.; Bristow, T. M.; Britton, D.; Britzger, D.; Brochu, F. M.; Brock, I.; Brock, R.; Bronner, J.; Brooijmans, G.; Brooks, T.; Brooks, W. K.; Brosamer, J.; Brost, E.; Brown, J.; Bruckman de Renstrom, P. A.; Bruncko, D.; Bruneliere, R.; Bruni, A.; Bruni, G.; Bruschi, M.; Bruscino, N.; Bryngemark, L.; Buanes, T.; Buat, Q.; Buchholz, P.; Buckley, A. G.; Buda, S. I.; Budagov, I. A.; Buehrer, F.; Bugge, L.; Bugge, M. K.; Bulekov, O.; Bullock, D.; Burckhart, H.; Burdin, S.; Burghgrave, B.; Burke, S.; Burmeister, I.; Busato, E.; Büscher, D.; Büscher, V.; Bussey, P.; Butler, J. M.; Butt, A. I.; Buttar, C. M.; Butterworth, J. M.; Butti, P.; Buttinger, W.; Buzatu, A.; Buzykaev, A. R.; Cabrera Urbán, S.; Caforio, D.; Cairo, V. M.; Cakir, O.; Calafiura, P.; Calandri, A.; Calderini, G.; Calfayan, P.; Caloba, L. P.; Calvet, D.; Calvet, S.; Camacho Toro, R.; Camarda, S.; Camarri, P.; Cameron, D.; Caminada, L. M.; Caminal Armadans, R.; Campana, S.; Campanelli, M.; Campoverde, A.; Canale, V.; Canepa, A.; Cano Bret, M.; Cantero, J.; Cantrill, R.; Cao, T.; Capeans Garrido, M. D. M.; Caprini, I.; Caprini, M.; Capua, M.; Caputo, R.; Cardarelli, R.; Cardillo, F.; Carli, T.; Carlino, G.; Carminati, L.; Caron, S.; Carquin, E.; Carrillo-Montoya, G. D.; Carter, J. R.; Carvalho, J.; Casadei, D.; Casado, M. P.; Casolino, M.; Castaneda-Miranda, E.; Castelli, A.; Castillo Gimenez, V.; Castro, N. F.; Catastini, P.; Catinaccio, A.; Catmore, J. R.; Cattai, A.; Caudron, J.; Cavaliere, V.; Cavalli, D.; Cavalli-Sforza, M.; Cavasinni, V.; Ceradini, F.; Cerio, B. C.; Cerny, K.; Cerqueira, A. S.; Cerri, A.; Cerrito, L.; Cerutti, F.; Cerv, M.; Cervelli, A.; Cetin, S. A.; Chafaq, A.; Chakraborty, D.; Chalupkova, I.; Chang, P.; Chapleau, B.; Chapman, J. D.; Charlton, D. G.; Chau, C. C.; Chavez Barajas, C. A.; Cheatham, S.; Chegwidden, A.; Chekanov, S.; Chekulaev, S. V.; Chelkov, G. A.; Chelstowska, M. A.; Chen, C.; Chen, H.; Chen, K.; Chen, L.; Chen, S.; Chen, X.; Chen, Y.; Cheng, H. C.; Cheng, Y.; Cheplakov, A.; Cheremushkina, E.; Cherkaoui El Moursli, R.; Chernyatin, V.; Cheu, E.; Chevalier, L.; Chiarella, V.; Childers, J. T.; Chiodini, G.; Chisholm, A. S.; Chislett, R. T.; Chitan, A.; Chizhov, M. V.; Choi, K.; Chouridou, S.; Chow, B. K. B.; Christodoulou, V.; Chromek-Burckhart, D.; Chudoba, J.; Chuinard, A. J.; Chwastowski, J. J.; Chytka, L.; Ciapetti, G.; Ciftci, A. 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B.; Vivarelli, I.; Vives Vaque, F.; Vlachos, S.; Vladoiu, D.; Vlasak, M.; Vogel, M.; Vokac, P.; Volpi, G.; Volpi, M.; von der Schmitt, H.; von Radziewski, H.; von Toerne, E.; Vorobel, V.; Vorobev, K.; Vos, M.; Voss, R.; Vossebeld, J. H.; Vranjes, N.; Vranjes Milosavljevic, M.; Vrba, V.; Vreeswijk, M.; Vuillermet, R.; Vukotic, I.; Vykydal, Z.; Wagner, P.; Wagner, W.; Wahlberg, H.; Wahrmund, S.; Wakabayashi, J.; Walder, J.; Walker, R.; Walkowiak, W.; Wang, C.; Wang, F.; Wang, H.; Wang, H.; Wang, J.; Wang, J.; Wang, K.; Wang, R.; Wang, S. M.; Wang, T.; Wang, X.; Wanotayaroj, C.; Warburton, A.; Ward, C. P.; Wardrope, D. R.; Warsinsky, M.; Washbrook, A.; Wasicki, C.; Watkins, P. M.; Watson, A. T.; Watson, I. J.; Watson, M. F.; Watts, G.; Watts, S.; Waugh, B. M.; Webb, S.; Weber, M. S.; Weber, S. W.; Webster, J. S.; Weidberg, A. R.; Weinert, B.; Weingarten, J.; Weiser, C.; Weits, H.; Wells, P. S.; Wenaus, T.; Wengler, T.; Wenig, S.; Wermes, N.; Werner, M.; Werner, P.; Wessels, M.; Wetter, J.; Whalen, K.; Wharton, A. M.; White, A.; White, M. J.; White, R.; White, S.; Whiteson, D.; Wickens, F. J.; Wiedenmann, W.; Wielers, M.; Wienemann, P.; Wiglesworth, C.; Wiik-Fuchs, L. A. M.; Wildauer, A.; Wilkens, H. G.; Williams, H. H.; Williams, S.; Willis, C.; Willocq, S.; Wilson, A.; Wilson, J. A.; Wingerter-Seez, I.; Winklmeier, F.; Winter, B. T.; Wittgen, M.; Wittkowski, J.; Wollstadt, S. J.; Wolter, M. W.; Wolters, H.; Wosiek, B. K.; Wotschack, J.; Woudstra, M. J.; Wozniak, K. W.; Wu, M.; Wu, M.; Wu, S. L.; Wu, X.; Wu, Y.; Wyatt, T. R.; Wynne, B. M.; Xella, S.; Xu, D.; Xu, L.; Yabsley, B.; Yacoob, S.; Yakabe, R.; Yamada, M.; Yamaguchi, Y.; Yamamoto, A.; Yamamoto, S.; Yamanaka, T.; Yamauchi, K.; Yamazaki, Y.; Yan, Z.; Yang, H.; Yang, H.; Yang, Y.; Yao, W.-M.; Yasu, Y.; Yatsenko, E.; Yau Wong, K. H.; Ye, J.; Ye, S.; Yeletskikh, I.; Yen, A. L.; Yildirim, E.; Yorita, K.; Yoshida, R.; Yoshihara, K.; Young, C.; Young, C. J. S.; Youssef, S.; Yu, D. R.; Yu, J.; Yu, J. M.; Yu, J.; Yuan, L.; Yurkewicz, A.; Yusuff, I.; Zabinski, B.; Zaidan, R.; Zaitsev, A. M.; Zalieckas, J.; Zaman, A.; Zambito, S.; Zanello, L.; Zanzi, D.; Zeitnitz, C.; Zeman, M.; Zemla, A.; Zengel, K.; Zenin, O.; Ženiš, T.; Zerwas, D.; Zhang, D.; Zhang, F.; Zhang, H.; Zhang, J.; Zhang, L.; Zhang, R.; Zhang, X.; Zhang, Z.; Zhao, X.; Zhao, Y.; Zhao, Z.; Zhemchugov, A.; Zhong, J.; Zhou, B.; Zhou, C.; Zhou, L.; Zhou, L.; Zhou, N.; Zhu, C. G.; Zhu, H.; Zhu, J.; Zhu, Y.; Zhuang, X.; Zhukov, K.; Zibell, A.; Zieminska, D.; Zimine, N. I.; Zimmermann, C.; Zimmermann, S.; Zinonos, Z.; Zinser, M.; Ziolkowski, M.; Živković, L.; Zobernig, G.; Zoccoli, A.; zur Nedden, M.; Zurzolo, G.; Zwalinski, L.

    2016-01-01

    The decays B_c^+ → J/ψ D_s^+ and B_c^+ → J/ψ D_s^{*+} are studied with the ATLAS detector at the LHC using a dataset corresponding to integrated luminosities of 4.9 and 20.6 fb^{-1} of pp collisions collected at centre-of-mass energies √{s} = 7 TeV and 8 TeV, respectively. Signal candidates are identified through J/ψ → μ ^+μ ^- and D_s^{(*)+}→ φ π ^+(γ /π ^0) decays. With a two-dimensional likelihood fit involving the B_c^+ reconstructed invariant mass and an angle between the μ ^+ and D_s^+ candidate momenta in the muon pair rest frame, the yields of B_c^+ → J/ψ D_s^+ and B_c^+ → J/ψ D_s^{*+}, and the transverse polarisation fraction in B_c^+ → J/ψ D_s^{*+} decay are measured. The transverse polarisation fraction is determined to be Γ _{± ± }(B_c^+ → J/ψ D_s^{*+})/Γ (B_c^+ → J/ψ D_s^{*+}) = 0.38 ± 0.23 ± 0.07, and the derived ratio of the branching fractions of the two modes is {B}_{B_c^+ → J/ψ D_s^{*+}}/{B}_{B_c^+ → J/ψ D_s^+} = 2.8 ^{+1.2}_{-0.8} ± 0.3, where the first error is statistical and the second is systematic. Finally, a sample of B_c^+→ J/ψ π ^+ decays is used to derive the ratios of branching fractions {B}_{B_c^+ → J/ψ D_s^+}/{B}_{B_c^+ → J/ψ π ^+} = 3.8 ± 1.1 ± 0.4 ± 0.2 and {B}_{B_c^+ → J/ψ D_s^{*+}}/{B}_{B_c^+ → J/ψ π ^+} = 10.4 ± 3.1 ± 1.5 ± 0.6, where the third error corresponds to the uncertainty of the branching fraction of D_s^+→ φ (K^+K^-)π ^+ decay. The available theoretical predictions are generally consistent with the measurement.

  10. Two Centuries of Solar Polarimetry

    NASA Astrophysics Data System (ADS)

    Harvey, J. W.

    2015-10-01

    In 1811, François Arago observed the disk of the Sun with his "lunette polariscopique". From the absence of detectable polarization compared with his laboratory observations of glowing solids, liquids, and flames he concluded that the Sun's visible surface is an incandescent gas. From this beginning, thanks to orders of magnitude technology improvements, a remarkable amount of what we know about the physics of the Sun has continued to flow from solar polarimetry. This short review compares some selected polarimetric discoveries with subsequent recent observations to illustrate the tremendous progress of solar polarimetry during the last two centuries.

  11. Effect of an ntrBC mutation on the posttranslational regulation of nitrogenase activity in Rhodospirillum rubrum.

    PubMed Central

    Zhang, Y; Cummings, A D; Burris, R H; Ludden, P W; Roberts, G P

    1995-01-01

    Homologs of ntrB and ntrC genes from Rhodospirillum rubrum were cloned and sequenced. A mutant lacking ntrBC was constructed, and this mutant has normal nitrogenase activity under nif-derepressing conditions, indicating that ntrBC are not necessary for the expression of the nif genes in R. rubrum. However, the post-translational regulation of nitrogenase activity by ADP-ribosylation in response to NH4+ was partially abolished in this mutant. More surprisingly, the regulation of nitrogenase activity in response to darkness was also affected, suggesting a physiological link between the ntr system and energy signal transduction in R. rubrum. The expression of glutamine synthetase, as well as its posttranslational regulation, was also altered in this ntrBC mutant. PMID:7665521

  12. Development and validation of the Female Sexual Function Index adaptation for breast cancer patients (FSFI-BC).

    PubMed

    Bartula, Iris; Sherman, Kerry A

    2015-08-01

    Sexual dysfunction following breast cancer treatment is common and screening for this is recommended. This study determined the reliability, validity, and acceptability of a breast cancer-specific adaptation of the Female Sexual Function Index, the FSFI-BC. This new measure addresses limitations in the FSFI when assessing sexual dysfunction of women with breast cancer regarding applicability to non-sexually active women, measuring distress and changes after cancer. Female breast cancer survivors (n = 596; 429 sexually active, 166 non-sexually active) completed an online survey including demographic/medical information, the FSFI-BC, and scales measuring sexual functioning, fatigue, body image, physical and mental health, and relationship adjustment (Time 1). Three weeks later, 326 women (245 sexually active; 81 non-sexually active) completed the Time 2 survey including the FSFI-BC, and questions regarding its acceptability and perceived change in sexual functioning. Reliability, construct validity, and acceptability were examined using standard scale validation techniques. Exploratory factor analysis delineated seven factors: Changes after cancer, desire/arousal, lubrication, orgasm, pain, satisfaction, and distress, accounting for 79.98 % (sexually active) and 77.19 % (non-active) variance in responses. Acceptable internal consistencies (non-active: α = 0.71-0.96; sexually active: α = 0.89-0.96) and test-retest reliabilities (non-active: r = 0.63-0.86; sexually active: r = 0.71-0.88) were evident. Inter-scale correlations provided evidence for convergent and divergent validities of the FSFI-BC. Both sexually active and non-active women provided positive feedback about the FSFI-BC. The optional partner questions demonstrated clinical utility. With desirable psychometric properties and acceptability to participants, the FSFI-BC is suitable for screening for sexual dysfunction in women with breast cancer. PMID:26198992

  13. Stochastic parameterization for light absorption by internally mixed BC/dust in snow grains for application to climate models

    NASA Astrophysics Data System (ADS)

    Liou, K. N.; Takano, Y.; He, C.; Yang, P.; Leung, L. R.; Gu, Y.; Lee, W. L.

    2014-06-01

    A stochastic approach has been developed to model the positions of BC (black carbon)/dust internally mixed with two snow grain types: hexagonal plate/column (convex) and Koch snowflake (concave). Subsequently, light absorption and scattering analysis can be followed by means of an improved geometric-optics approach coupled with Monte Carlo photon tracing to determine BC/dust single-scattering properties. For a given shape (plate, Koch snowflake, spheroid, or sphere), the action of internal mixing absorbs substantially more light than external mixing. The snow grain shape effect on absorption is relatively small, but its effect on asymmetry factor is substantial. Due to a greater probability of intercepting photons, multiple inclusions of BC/dust exhibit a larger absorption than an equal-volume single inclusion. The spectral absorption (0.2-5 µm) for snow grains internally mixed with BC/dust is confined to wavelengths shorter than about 1.4 µm, beyond which ice absorption predominates. Based on the single-scattering properties determined from stochastic and light absorption parameterizations and using the adding/doubling method for spectral radiative transfer, we find that internal mixing reduces snow albedo substantially more than external mixing and that the snow grain shape plays a critical role in snow albedo calculations through its forward scattering strength. Also, multiple inclusion of BC/dust significantly reduces snow albedo as compared to an equal-volume single sphere. For application to land/snow models, we propose a two-layer spectral snow parameterization involving contaminated fresh snow on top of old snow for investigating and understanding the climatic impact of multiple BC/dust internal mixing associated with snow grain metamorphism, particularly over mountain/snow topography.

  14. Measurements of Refractory Black Carbon (rBC) Aerosols in the McMurdo Dry Valleys, Antarctica

    NASA Astrophysics Data System (ADS)

    Khan, A. L.; McMeeking, G. R.; Lyons, W. B.; Schwarz, J. P.; Welch, K. A.; McKnight, D. M.

    2015-12-01

    Measurements of light absorbing particles in the boundary layer of the high southern latitudes are scarce. During the 2013-2014 austral summer field season refractory black carbon (rBC) aerosols were quantified by a single particle soot photometer (SP2) in the McMurdo Dry Valleys, Antarctica. The dark rBC particles absorb more radiation thereby increasing atmospheric heating, as well as reducing surface albedo and enhancing hydrologic melt when deposited on highly reflective surfaces such as snow and ice. Quantifying both local and long-range atmospheric transport of rBC to this region of a remote continent mostly covered by ice and snow would be useful in understanding meltwater generation as climate changes. Although the Dry Valleys are the largest ice-free region of Antarctica, they contain many alpine glaciers, some of which are fed from the East Antarctic Ice Sheet (EAIS). Continuous rBC measurements were collected at Lake Hoare Camp in the Taylor Valley for two months, along with shorter periods at more remote locations within the Dry Valleys. Conditions at the Lake Hoare Camp were dominated by up-valley winds from McMurdo Sound, however, winds also brought air down-valley from the EAIS polar plateau. Here we investigated periods dominated by both up and down-valley winds to explore differences in rBC concentrations, size distributions, and scattering properties. The average background rBC mass concentration was 1ng/m3, though concentrations as high as 50 ng/m3 were observed at times, likely due to local sources.

  15. Characterization of black pigment used in 30 BC fresco wall paint using instrumental methods and chemometry

    PubMed Central

    2012-01-01

    Background and methods Several standard powdered black pigments were characterized by means of thermogravimetry TG-DTG and allied techniques. These pigments were used to make standard plaster frescoes at this purpose prepared. The latter ones were subjected to Raman and reflectance analysis. The results obtained, together with TG data, were chemometrically processed and used to identify an analogous standard fresco fabricated by an unknown commercial black pigment, obtaining excellent results. Results The same colorimetric and reflectometric techniques, coupled with suitable chemometric techniques, were then successfully used to identify the type of black pigment present in an ancient roman fresco of the Imperial Age (30 B.C.). Conclusion TG-DTG resulted useful techniques to autenticate powdered black pigments.Colorimetry and Raman, but also the only colorimetry, were useful to identify an ancient black pigment in situ. PMID:22594437

  16. Response of BC-418 plastic scintillator to low-energy protons

    NASA Astrophysics Data System (ADS)

    Daub, B. H.; Henzl, V.; Kovash, M. A.; Matthews, J. L.; Miller, Z. W.; Shoniyozov, K.; Yang, H.

    2013-02-01

    The response of fast plastic scintillators to protons is unknown for energies below approximately 300 keV. The response of BC-418 plastic scintillator to protons from 100 keV to 1 MeV was measured using elastic scattering of neutrons at the University of Kentucky. Protons of precise energies from a Van de Graaff accelerator impinged on a thin LiF target to produce neutrons in narrow energy bands. A coincidence was detected between the recoiling proton in the plastic scintillator and the elastically scattered neutron in a liquid scintillator. The energy of the recoil proton was determined by the elastic scattering kinematics, with the scattered neutron energy precisely determined by time of flight. The results are compared with previous measurements of the response of similar plastic scintillators in the energy region where they overlap.

  17. Ab Initio and Phenomenological Modeling of the Phonon Spectrum of Superhard cp-BC2N

    NASA Astrophysics Data System (ADS)

    Basalaev, Yu. M.; Kopytov, A. V.; Pavlova, T. Yu.; Poplavnoi, A. S.

    2015-11-01

    The phonon spectrum of hypothetical superhard cp-BC2N is calculated based on ab initio method of density functional in the center of the Brillouin zone and interpolated over the entire Brillouin zone using the Keating phenomenological model. The interaction parameters are determined by optimization of the IR- and Ramanactive frequencies for a phenomenological model by their comparison with the results of ab initio calculations. Numerical values of short-range interaction constants and charges are in agreement with the characteristics of the chemical bond calculated ab initio. These parameters have transparent physical meaning and chemical nature and can further be used for both qualitative estimations of any physical and physico-chemical quantities and quantitative calculations of the phonon spectra of a number of isostructural compounds. The Keating phenomenological model is used to study the genesis of the phonon spectrum from the spectra of sublattices.

  18. Effect of exogenous electron shuttles on growth and fermentative metabolism in Clostridium sp. BC1

    SciTech Connect

    Yarlagadda V. N.; Francis A.; Gupta, A.; Dodge, C. J.

    2012-03-01

    In this study, the influence exogenous electron shuttles on the growth and glucose fermentative metabolism of Clostridium sp. BC1 was investigated. Bicarbonate addition to mineral salts (MS) medium accelerated growth and glucose fermentation which shifted acidogenesis (acetic- and butyric-acids) towards solventogenesis (ethanol and butanol). Addition of ferrihydrite, anthraquinone disulfonate, and nicotinamide adenine dinucleotide in bicarbonate to growing culture showed no significant influence on fermentative metabolism. In contrast, methyl viologen (MV) enhanced ethanol- and butanol-production by 28- and 12-fold, respectively with concomitant decrease in hydrogen, acetic- and butyric-acids compared to MS medium. The results show that MV addition affects hydrogenase activity with a significant reduction in hydrogen production and a shift in the direction of electron flow towards enhanced production of ethanol and butanol.

  19. Pectus excavatum in relief from Ancient Egypt (dating back to circa 2400 BC).

    PubMed

    Bialas, Adam J; Kaczmarski, Jacek; Kozak, Jozef; Kempinska-Miroslawska, Bogumila

    2015-04-01

    Pectus excavatum is one of the most common congenital deformities of the chest wall. The aim of the study was to analyse 621 artefacts (reliefs, sculptures, paintings) from Ancient Egypt in terms of anatomical defects of the chest. The team which analysed artefacts consisted of historians of medicine and thoracic surgeons. The researchers found a relief, depicting a man with an abnormal shape of the chest. The relief was from Niankhkhnum and Khnumhotep mastaba and dates back to circa 2400 BC. The authors think it is possible that the relief may represent a pectus excavatum deformity and believe the image will open up debate on the occurrence of this deformity in ancient times. PMID:25564580

  20. Effect of edge modification on the zigzag BC2N nanoribbons

    NASA Astrophysics Data System (ADS)

    Xiao, Xiang; Li, Hong; Tie, Jun; Lu, Jing

    2016-08-01

    We use first principles calculations to investigate the effects of edge modification with nonmetal species on zigzag-edged BC2N nanoribbons (ZBC2NNRs). These ZBC2NNRs show either semiconducting or metallic behaviors depending on the edge modifications and ribbon widths. We find that the O-modification induces a ferromagnetic ground state with a metallic behavior for all the ribbon widths investigated. And when the ribbon width is more than 3.32 nm (NZ ⩾ 16), an antiferromagnetic ground state with a half-metallic behavior is realized in the H-passivated ZBC2NNRs. These versatile electronic properties render the ZBC2NNRs a promising candidate material in nanoelectronics and nanospintronics.

  1. Decipher the short-distance component of X(3872) in Bc decays

    NASA Astrophysics Data System (ADS)

    Wang, Wei; Zhao, Qiang

    2016-04-01

    A foremost task in understanding the nature of the X (3872) involves the discrimination of the two-quark and multiquark configurations. In this work, we propose a method to probe the short-distance component of the X (3872) by measuring the ratio between the Bc semileptonic and nonleptonic decays into the X (3872). We demonstrate that if the X (3872) production mechanism is through the c bar c component, the ratios would be universal and could be reliably predicted in theory. Measurements of these ratios at LHC and the next-generation electron-positron colliders are capable of validating/invalidating this production mechanism and providing deeper insights into the nature of the X (3872).

  2. OPS MCC level B/C formulation requirements: Area targets and space volumes processor

    NASA Technical Reports Server (NTRS)

    Bishop, M. J., Jr.

    1979-01-01

    The level B/C mathematical specifications for the area targets and space volumes processor (ATSVP) are described. The processor is designed to compute the acquisition-of-signal (AOS) and loss-of-signal (LOS) times for area targets and space volumes. The characteristics of the area targets and space volumes are given. The mathematical equations necessary to determine whether the spacecraft lies within the area target or space volume are given. These equations provide a detailed model of the target geometry. A semianalytical technique for predicting the AOS and LOS time periods is disucssed. This technique was designed to bound the actual visibility period using a simplified target geometry model and unperturbed orbital motion. Functional overview of the ATSVP is presented and it's detailed logic flow is described.

  3. bcRep: R Package for Comprehensive Analysis of B Cell Receptor Repertoire Data.

    PubMed

    Bischof, Julia; Ibrahim, Saleh M

    2016-01-01

    Immunoglobulins, as well as T cell receptors, play a key role in adaptive immune responses because of their ability to recognize antigens. Recent advances in next generation sequencing improved also the quality and quantity of individual B cell receptors repertoire sequencing. Unfortunately, appropriate software to exhaustively analyze repertoire data from NGS platforms without limitations of the number of sequences are lacking. Here we introduce a new R package, bcRep, which offers a platform for comprehensive analyses of B cell receptor repertoires, using IMGT/HighV-QUEST formatted data. Methods for gene usage statistics, clonotype classification, as well as diversity measures, are included. Furthermore, functions to filter datasets, to do summary statistics about mutations, as well as visualization methods, are available. To compare samples in respect of gene usage, diversity, amino acid proportions, similar sequences or clones, several functions including also distance measurements, as well as multidimensional scaling methods, are provided. PMID:27551775

  4. bcRep: R Package for Comprehensive Analysis of B Cell Receptor Repertoire Data

    PubMed Central

    Ibrahim, Saleh M.

    2016-01-01

    Immunoglobulins, as well as T cell receptors, play a key role in adaptive immune responses because of their ability to recognize antigens. Recent advances in next generation sequencing improved also the quality and quantity of individual B cell receptors repertoire sequencing. Unfortunately, appropriate software to exhaustively analyze repertoire data from NGS platforms without limitations of the number of sequences are lacking. Here we introduce a new R package, bcRep, which offers a platform for comprehensive analyses of B cell receptor repertoires, using IMGT/HighV-QUEST formatted data. Methods for gene usage statistics, clonotype classification, as well as diversity measures, are included. Furthermore, functions to filter datasets, to do summary statistics about mutations, as well as visualization methods, are available. To compare samples in respect of gene usage, diversity, amino acid proportions, similar sequences or clones, several functions including also distance measurements, as well as multidimensional scaling methods, are provided. PMID:27551775

  5. Direct evidence for the atovaquone action on the Plasmodium cytochrome bc1 complex.

    PubMed

    Siregar, Josephine E; Kurisu, Genji; Kobayashi, Tamaki; Matsuzaki, Motomichi; Sakamoto, Kimitoshi; Mi-ichi, Fumika; Watanabe, Yoh-ichi; Hirai, Makoto; Matsuoka, Hiroyuki; Syafruddin, Din; Marzuki, Sangkot; Kita, Kiyoshi

    2015-06-01

    Atovaquone, a coenzyme Q analogue has been indicated to specifically target the cytochrome bc1 complex of the mitochondrial respiratory chain in the malarial parasite and other protozoan. Various mutations in the quinone binding site of the cytochrome b gene of Plasmodium spp. such as M133I, L144S, L271V, K272R, Y268C, Y268S, Y268N, and V284F are suggesting to associate with resistance to atovaquone. There is no direct evidence of relation between the mutations and resistance to atovaquone in Plasmodium parasite that has been available. Technical difficulties in isolating active assayable mitochondria in the malarial parasite hinder us to obtain direct biochemical evidence to support the relation between the mutations and drug resistance. The establishment of a mitochondrial isolation method for the malaria parasite has allowed us to test the degree of resistance of Plasmodium berghei isolates to atovaquone directly. We have tested the activity of dihydroorotate (DHO)-cytochrome c reductase in various P. berghei atovaquone resistant clones in the presence of a wide concentration range of atovaquone. Our results show the IC(50) of P. berghei atovaquone resistant clones is much higher (1.5 up to 40 nM) in comparison to the atovaquone sensitive clones (0.132-0.465 nM). The highest IC(50) was revealed in clones carrying Y268C and Y268N mutations (which play an important role in atovaquone resistance in Plasmodium falciparum), with an approximately 100-fold increase. The findings indicate the importance of the mutation in the quinone binding site of the cytochrome b gene and that provide a direct evidence for the atovaquone inhibitory mechanism in the cytochrome bc1 complex of the parasite. PMID:25264100

  6. THE BC CRIBS & TRENCHES GEOPHYSICAL CHARACTERIZATION PROJECT ONE STEP FORWARD IN HANFORDS CLEANUP PROCESS

    SciTech Connect

    BENECKE, M.W.

    2005-11-17

    A geophysical characterization project was conducted at the BC Cribs and Trenches Area, located south of 200 East at the Hanford Site. The area consists of 26 waste disposal trenches and cribs, which received approximately 30 million gallons of liquid waste from the uranium recovery process and the ferrocyanide processes associated with wastes generated by reprocessing nuclear fuel. Waste discharges to BC Cribs contributed perhaps the largest liquid fraction of contaminants to the ground in the 200 Areas. The site also includes possibly the largest inventory of Tc-99 ever disposed to the soil at Hanford with an estimated quantity of 400 Ci. Other waste constituents included high volumes of nitrate and U-238. The geophysical characterization at the 50-acre site primarily included high resolution resistivity (HRR). The resistivity technique is a non-invasive method by which electrical resistivity data are collected along linear transects, and data are presented as continuous profiles of subsurface electrical properties. The transects ranged in size from about 400-700 meters and provided information down to depths of 60 meters. The site was characterized by a network of 51 HRR lines with a total of approximately 19.7 line kilometers of data collected parallel and perpendicular to the trenches and cribs. The data were compiled to form a three-dimensional representation of low resistivity values. Low resistivity, or high conductivity, is indicative of high ionic strength soil and porewater resulting from the migration of nitrate and other inorganic constituents through the vadose zone. High spatial density soil data from a single borehole, that included coincident nitrate concentrations, electrical conductivity. and Tc-99, were used to transform the electrical resistivity data into a nitrate plume. The plume was shown to extend laterally beyond the original boundaries of the waste site and, in one area, to depths that exceeded the characterization strategy.

  7. THE BC CRIBS & TRENCHES GEOPHYSICAL CHARACTERIZATION PROJECT ONE STEP FORWARD IN HANFORDS CLEANUP PROCESS

    SciTech Connect

    BENECKE, MN.W.

    2006-02-22

    A geophysical characterization project was conducted at the BC Cribs and Trenches Area, located south of 200 East at the Hanford Site. The area consists of 26 waste disposal trenches and cribs, which received approximately 30 million gallons of liquid waste from the uranium recovery process and the ferrocyanide processes associated with wastes generated by reprocessing nuclear fuel. Waste discharges to BC Cribs contributed perhaps the largest liquid fraction of contaminants to the ground in the 200 Areas. The site also includes possibly the largest inventory of Tc-99 ever disposed to the soil at Hanford with an estimated quantity of 400 Ci. Other waste constituents included high volumes of nitrate and U-238. The geophysical characterization at the 50 acre site primarily included high resolution resistivity (HRR). The resistivity technique is a non-invasive method by which electrical resistivity data are collected along linear transects, and data are presented as continuous profiles of subsurface electrical properties. The transects ranged in size from about 400-700 meters and provided information down to depths of 60 meters. The site was characterized by a network of 51 HRR lines with a total of approximately 19.7 line kilometers of data collected parallel and perpendicular to the trenches and cribs. The data were compiled to form a three-dimensional representation of low resistivity values. Low resistivity, or high conductivity, is indicative of high ionic strength soil and porewater resulting from the migration of nitrate and other inorganic constituents through the vadose zone. High spatial density soil data from a single borehole, that included coincident nitrate concentrations, electrical conductivity, and Tc-99, were used to transform the electrical resistivity data into a nitrate plume. The plume was shown to extend laterally beyond the original boundaries of the waste site and, in one area, to depths that exceeded the characterization strategy. It is

  8. Dissociation of insulin receptor phosphorylation and stimulation of glucose transport in BC3H-1 myocytes

    SciTech Connect

    Mojsilovic, L.P.; Standaert, M.L.; Rosic, N.K.; Pollet, R.J.

    1986-05-01

    The authors have investigated insulin receptor phosphorylation in differentiated cultured BC3H-1 myocytes. As for other insulin-responsive cell systems in partially purified wheat germ agglutinin receptor preparations, insulin stimulates the phosphorylation of its own receptor (95K ..beta..-subunits) in a dose dependent manner (0-400 nM), as identified by immunoprecipitation with antiinsulin receptor antibodies and SDS-PAGE. In the same preparations they show that 12-0-tetradecanyl phorbol acetate (TPA), which in many respect ..beta..-subunits in the same dose dependent manner (0-5 ..mu..M). In addition, antiinsulin receptor antibodies (B-10) also induced phosphorylation of mimics insulin action, also induced phosphorylation of the insulin receptor and HPLC tryptic maps of the /sup 32/P-labeled ..beta..-subunit were identical to those for insulin-induced receptor phosphorylation. However, while insulin and TPA are potent stimulators of glucose transport in these muscle cells, the antireceptor antibodies alone failed to provoke glucose transport at any concentration. The specificity and activity of these antibodies were confirmed in their system by their ability to inhibit insulin binding and insulin-stimulated glucose transport in a concentration-dependent manner. Their results indicate that phosphorylation of insulin receptor is not a crucial event in mediating insulin action, at least with respect to glucose transport. While the effects of the B-10 antibody in the BC3H-1 myocyte differ from those in the adipocyte, their results provide independent confirmation of their essential conclusion that phosphorylation of the insulin receptor may not be necessary nor sufficient for its acute action in promoting glucose transport.

  9. Potential vorticity and layer thickness variations in the flow around Jupiter's Great Red Spot and White Oval BC

    NASA Technical Reports Server (NTRS)

    Dowling, Timothy E.; Ingersoll, Andrew P.

    1988-01-01

    Using Voyager images, layer thickness variations in the flow around Jupiter's Great Red Spot (GRS) and White Oval BC were investigated by treating potential vorticity as a conserved tracer. Fluid trajectories around the GRS and the White Oval BC were calculated assuming the flow to be frictionless, adiabatic, hydrostatic, and steady in the reference frame of the vortex. The data obtained constitute a useful diagnostic which will help to differentiate between models of Jovian vortices. Implications of the observations were studied in the context of a one-layer quasi-geostrophic model in which a thin upper weather layer, which contains the vortex, is supported hydrostatically by a much deeper lower layer.

  10. Potential vorticity and layer thickness variations in the flow around Jupiter's Great Red SPOT and White Oval BC

    NASA Astrophysics Data System (ADS)

    Dowling, T. E.; Ingersoll, A. P.

    1988-04-01

    Using Voyager images, layer thickness variations in the flow around Jupiter's Great Red Spot (GRS) and White Oval BC were investigated by treating potential vorticity as a conserved tracer. Fluid trajectories around the GRS and the White Oval BC were calculated assuming the flow to be frictionless, adiabatic, hydrostatic, and steady in the reference frame of the vortex. The data obtained constitute a useful diagnostic which will help to differentiate between models of Jovian vortices. Implications of the observations were studied in the context of a one-layer quasi-geostrophic model in which a thin upper weather layer, which contains the vortex, is supported hydrostatically by a much deeper lower layer.

  11. Scenarios of 21st-century trans-Arctic shipping for climate studies

    NASA Astrophysics Data System (ADS)

    Stephenson, S. R.; Davis, S. J.; Zender, C. S.; Smith, L. C.

    2013-12-01

    Receding Arctic sea ice coupled with increased resource demand in east Asia have recast the Arctic as an international trade space facilitating export of petroleum and minerals and offering potential alternative pathways for global maritime trade. Several studies have examined the future impact of increased vessel traffic in the Arctic on emissions of greenhouse gases and black carbon (BC); however, the net impact of these emissions on climate forcing in the region is not well understood. Here we present several scenarios of 21st-century trans-Arctic shipping for climate studies. Vessel transits between 5 east Asian ports (Tianjin, Shanghai, Hong Kong, Tokyo/Yokohama, Busan) and 2 European ports (Rotterdam, Hamburg) are estimated from 2010-2050 according to projected sea ice concentration and thickness, trends in cargo export volumes, and vessel ice class and cargo capacity. Sea ice data are represented by a 7-model ensemble mean from CMIP5 under two forcing scenarios (RCP 4.5/8.5). Emissions presented (CO2, CH4, N2O, NOx, SOx, BC) are obtained by convolving projected transits with trends in emissions factors. Results illustrate a range of emissions inventories for the Arctic owing to differences in vessel accessibility, trade volume, routes, and fuel mixtures.

  12. BC1-FMRP interaction is modulated by 2′-O-methylation: RNA-binding activity of the tudor domain and translational regulation at synapses

    PubMed Central

    Lacoux, Caroline; Di Marino, Daniele; Pilo Boyl, Pietro; Zalfa, Francesca; Yan, Bing; Ciotti, Maria Teresa; Falconi, Mattia; Urlaub, Henning; Achsel, Tilmann; Mougin, Annie; Caizergues-Ferrer, Michèle; Bagni, Claudia

    2012-01-01

    The brain cytoplasmic RNA, BC1, is a small non-coding RNA that is found in different RNP particles, some of which are involved in translational control. One component of BC1-containing RNP complexes is the fragile X mental retardation protein (FMRP) that is implicated in translational repression. Peptide mapping and computational simulations show that the tudor domain of FMRP makes specific contacts to BC1 RNA. Endogenous BC1 RNA is 2′-O-methylated in nucleotides that contact the FMRP interface, and methylation can affect this interaction. In the cell body BC1 2′-O-methylations are present in both the nucleus and the cytoplasm, but they are virtually absent at synapses where the FMRP–BC1–mRNA complex exerts its function. These results strongly suggest that subcellular region-specific modifications of BC1 affect the binding to FMRP and the interaction with its mRNA targets. We finally show that BC1 RNA has an important role in translation of certain mRNAs associated to FMRP. All together these findings provide further insights into the translational regulation by the FMRP–BC1 complex at synapses. PMID:22238374

  13. High altitude balloon measurements of free tropospheric black carbon: Do BC aerosol layers build "their own homes" up in the atmosphere?

    NASA Astrophysics Data System (ADS)

    Babu, S. Suresh; Manchanda, R. K.; Shankarnarayan, Sreenivasan; Sinha, P. R.; Krishna Moorthy, K.; Prasad Vajja, Dinakar; Arunkumar, V. H.; Satheesh, S. K.

    2012-07-01

    First ever high altitude balloon measurements of the vertical profiles of the mass concentration of aerosol black carbon (BC) concurrently with the atmospheric thermodynamical parameters were made in the troposphere ( up to 9 km) from the National Balloon Facility at Hyderabad as a part of the Regional Aerosol warming Experiment (RAWEX) of ARFI Project (ISRO-GBP) during March 2010. The altitude distribution of BC showed multiple peaks, at ˜ 4.5 km and above 8 km. Associated with these, rapid decrease in the environmental lapse rate and a sharp increase in the atmospheric stability were observed, probably caused by the atmospheric warming by the BC layers. Estimation of the heating rate profile using the altitude distribution of BC and the vertical profile of extinction coefficient from the CALIPSO, which had an over pass over the region on the day of BC profiling, revealed very large heating (˜ 2.8 K day-1) at ˜ 4.5 km. This experiment provided the first experimental evidence and quantification of the effects of BC absorption on the stability of the atmosphere. The elevated BC layers in the free troposphere absorb solar radiation leading to warming of the local ambient, which increases the atmospheric stability. The stable layer, thus created, is conducive for maintaining the BC layer longer, without dissipation (by inhibiting turbulent mixing) and thus increases its lifetime leading to further enhanced absorption. Thus raises an interesting question: Do BC layers build `their own homes' up in the atmosphere?

  14. The Search for Astronomical Alignments in the Seventh Century A.D. Silla Capital at Kyongju, Korea

    NASA Astrophysics Data System (ADS)

    Nelson, S. M.; Stencel, R. E.

    1999-05-01

    In the center of the modern Korean city of Kyongju stands a modest structure dating from the 7th century AD, known as Chomsongdae, or the Star Observatory. Known locally as the oldest observatory in Asia, details of its precise use are lost, but its construction coincided with the height of Silla culture and its dominance over the Korean peninsula. Radially from the structure are located the so-called Moon Fortress, numerous large tombsites for elite of the culture, plus hillside fortresses and elaborate Buddhist temples. During 1999, we've conducted a course at Denver as part of our Core Curriculum program for The Women's College, that has examined the astronomical and cultural aspects of the Kyongju site, to attempt to determine whether the architects may have included astronomical alignments into the ``Feng Shui" of their city planning, spanning centuries. The preliminary result of our studies suggests that east and west of Star Observatory lay fortress and wall features that may have been useful for equinox determination. A discussion of ethnographic supporting evidence will be provided, but additional on-site observations will be needed to confirm the idea.

  15. Rapid landscape change in 6th century northern Jordan: interdisciplinary geoarchaeological perspectives

    NASA Astrophysics Data System (ADS)

    Lucke, Bernhard

    2016-04-01

    Landscapes of the ancient fertile crescent are considered affected by soil degradation as result of long-term farming since the Neolithic, and impressive ruins of antiquity led to assumptions that their abandonment must have been conntected with reduced agricultural productivity. In this context, a valley fill near the site of Abila of the Decapolis in northern Jordan was apparently deposited largely during the 6th century AD, and provides evidence for a rapid and intense landscape change during the Late Byzantine period. However, an interdisciplinary case study of land use, soil development, and sediments found that the valley fill cannot be connected with large-scale soil erosion in the vicinity of the site. On the one hand, this is indicated by the distribution of soil development and archaeological material as marker of past land use activity in the past, which suggests that the best soils were and still are used intensively. On the other hand, the sediments seem to point to the occurrence of climatic extremes such as heavy floods, the occurrence of soil creep after water saturation, but also a significant shift to aridity which may have triggered socio-economic changes of subsistence strategies from agriculture to pastoralism. The dates of sediments which are available so far indicate that the climatic change seemingly occurred rapidly within approximately 100 years during the late 6th and early 7th century AD, possibly connected with the "year without sun" or 'Mystery Veil' which the Byzantine historian Procopius described in the year 536 AD. Modern analogies of the Pinatubo eruption in 1991 let it seem possible that a volcanic event, perhaps the outbreak of the Ilopango volcano, was connected with these environmental turbulences. Such events cannot be understood by isolated studies: without a broad interdisciplinary framework, single archives are prone to misinterpretation, and our understanding of the environmental history of Abila is still very limited.

  16. Teaching health in the 21st century.

    PubMed

    Halbert, Lee-Ann

    2015-01-01

    School nurses have a broad scope of practice, including direct clinical care, as well as teaching health lessons. Students in the 21st century require educators who understand the current global needs of these learners. Effective health teaching meets these 21st-century needs. This article presents a background of 21st-century learning, with specific recommendations for teaching this generation of students. PMID:25626242

  17. Urbanization in 21st century.

    PubMed

    Altarejos, R G

    1990-01-01

    Due to a combination of rapid population growth and high levels of rural-urban migration, overcrowding will be common in many cities around the world in the 21st century. Currently at 5.3 billion, the global population is expected to increase to 6 billion by the year 2000, and to 9 billion by 2025. Experts predict that urban centers will bear the brunt of the population growth. Rural areas have seen declines in the standard of living, partly due to natural disasters, civil war, and economic policies favoring urban centers. In search of jobs, better access to education, and health services, rural populations will flock to cities. But the rapid growth of cities will inevitably lead to the creation of slums, which will hamper urban development. Urban demographers predict that by the end of the century, 1/2 of the world's population will be urban, and 1/5 of these people will be concentrated in "mega cities," populations of 4 million or more. International migration will play a significant role, as people cross borders in search of opportunity. But contrary to the traditional model of urban growth, much of it will take place in developing countries. According to a 1985 study, developed nations had an urbanization level of 71%, compared to 31% in developing countries. However, experts calculate that by 2025, these levels will practically even out, with an urbanization level of 74% for developing countries and 77% for developed countries. By 2025, 25 cities will have populations of over 9 million, including Mexico City (25.8), Sao Paulo (24.0), Tokyo (20.2), Calcutta (16.5), Greater Bombay (16.0), and New York (15.8). PMID:12343167

  18. BEEC: An event generator for simulating the Bc meson production at an e+e- collider

    NASA Astrophysics Data System (ADS)

    Yang, Zhi; Wu, Xing-Gang; Wang, Xian-You

    2013-12-01

    The Bc meson is a doubly heavy quark-antiquark bound state and carries flavors explicitly, which provides a fruitful laboratory for testing potential models and understanding the weak decay mechanisms for heavy flavors. In view of the prospects in Bc physics at the hadronic colliders such as Tevatron and LHC, Bc physics is attracting more and more attention. It has been shown that a high luminosity e+e- collider running around the Z0-peak is also helpful for studying the properties of Bc meson and has its own advantages. For this purpose, we write down an event generator for simulating Bc meson production through e+e- annihilation according to relevant publications. We name it BEEC, in which the color-singlet S-wave and P-wave (cb¯)-quarkonium states together with the color-octet S-wave (cb¯)-quarkonium states can be generated. BEEC can also be adopted to generate the similar charmonium and bottomonium states via the semi-exclusive channels e++e-→|(QQ¯)[n]>+Q+Q¯ with Q=b and c respectively. To increase the simulation efficiency, we simplify the amplitude as compact as possible by using the improved trace technology. BEEC is a Fortran program written in a PYTHIA-compatible format and is written in a modular structure, one may apply it to various situations or experimental environments conveniently by using the GNU C compiler make. A method to improve the efficiency of generating unweighted events within PYTHIA environment is proposed. Moreover, BEEC will generate a standard Les Houches Event data file that contains useful information of the meson and its accompanying partons, which can be conveniently imported into PYTHIA to do further hadronization and decay simulation. Catalogue identifier: AEQC_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEQC_v1_0.html Program obtainable from: CPC Program Library, Queen’s University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in

  19. Profile of BC College Transfer Students Admitted to the University of Victoria 2003/04 to 2007/08

    ERIC Educational Resources Information Center

    Martell, Jim; Wilson, Alan

    2009-01-01

    This report examines the population of college transfer students who entered the University of Victoria (UVic) from 2003/04 to 2007/08, updating a June 2004 report. Section A provides a general profile of the 6,917 British Columbia (BC) college transfer students who first registered and commenced studies at UVic in any session between summer 2003…

  20. Following Their Footsteps: What Happens to Students Who Move from Research Universities to Other BC Public Post-Secondary Institutions?

    ERIC Educational Resources Information Center

    Heslop, Joanne

    2011-01-01

    British Columbia has a differentiated post-secondary system in which different kinds of institutions provide students with a wide range of educational program options and numerous opportunities for credential completion. As a result of the many education choices and pathways available to students in BC, they tend to navigate their way through the…

  1. A Survey of Movers: Students Who Move between BC Public Post-Secondary Institutions. A Summary of Findings

    ERIC Educational Resources Information Center

    British Columbia Council on Admissions and Transfer, 2013

    2013-01-01

    Over the last several years, there has been a wealth of new data on student mobility in British Columbia's postsecondary system. Quantitative information from the Student Transitions Project (STP) has allowed current and prospective students, the BC Council on Admissions and Transfer (BCCAT), public post-secondary institutions, the Ministry…

  2. Inhibitor-complexed Structures of the Cytochrome bc[subscript 1] from the Photosynthetic Bacterium Rhodobacter sphaeroides

    SciTech Connect

    Esser, Lothar; Elberry, Maria; Zhou, Fei; Yu, Chang-An; Yu, Linda; Xia, Di

    2008-06-30

    The cytochrome bc{sub 1} complex (bc{sub 1}) is a major contributor to the proton motive force across the membrane by coupling electron transfer to proton translocation. The crystal structures of wild type and mutant bc{sub 1} complexes from the photosynthetic purple bacterium Rhodobacter sphaeroides (Rsbc{sub 1}), stabilized with the quinol oxidation (Q{sub P}) site inhibitor stigmatellin alone or in combination with the quinone reduction (Q{sub N}) site inhibitor antimycin, were determined. The high quality electron density permitted assignments of a new metal-binding site to the cytochrome c1 subunit and a number of lipid and detergent molecules. Structural differences between Rsbc{sub 1} and its mitochondrial counterparts are mostly extra membranous and provide a basis for understanding the function of the predominantly longer sequences in the bacterial subunits. Functional implications for the bc{sub 1} complex are derived from analyses of 10 independent molecules in various crystal forms and from comparisons with mitochondrial complexes.

  3. Determination of the energy dependence of the BC-408 plastic scintillation detector in medium energy x-ray beams

    NASA Astrophysics Data System (ADS)

    Yücel, H.; Çubukçu, Ş.; Uyar, E.; Engin, Y.

    2014-11-01

    The energy dependence of the response of BC-408 plastic scintillator (PS), an approximately water-equivalent material, has been investigated by employing standardized x-ray beams. IEC RQA and ISO N series x-ray beam qualities, in the range of 40-100 kVp, were calibrated using a PTW-type ionization chamber. The energy response of a thick BC-408 PS detector was measured using the multichannel pulse height analysis method. The response of BC-408 PS increased gradually with increasing energy in the energy range of 40-80 kVp and then showed a flat behavior at about 80 to 120 kVp. This might be due to the self-attenuation of scintillation light by the scintillator itself and may also be partly due to the ionization quenching, leading to a reduction in the intensity of the light output from the scintillator. The results indicated that the sensitivity drop in BC-408 PS material at lower photon energies may be overcome by adding some high-Z elements to its polyvinyltoluene (PVT) base. The material modification may compensate for the drop in the response at lower photon energies. Thus plastic scintillation dosimetry is potentially suitable for applications in diagnostic radiology.

  4. Profile of BC College Transfer Students Admitted to the University of British Columbia: 2003/04 to 2007/08

    ERIC Educational Resources Information Center

    Lambert-Maberly, Ashley

    2009-01-01

    This report examines the demographics, performance, and success of students who were admitted to the University of British Columbia's Vancouver campus on the basis of a minimum 24 transfer credits earned at a BC college during the five year period comprising the 2003/04 through 2007/08 academic years. The report mines familiar ground--similar…

  5. Neural Tube Defect Induction by Fumonisin B1 in LM/Bc Mice Fed Folate Deficient or Folate Replete Diets

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Fumonisin B1 (FB1) is a mycotoxin produced by Fusarium verticillioides and F. proliferatum. FB1 is found in corn-based foods and evidence suggests that it is a risk factor for neural tube defects (NTD). The mechanism(s) underlying NTD induction by FB1 in the sensitive LM/Bc mouse model is not well...

  6. Part 2: the Earliest World Map, Babylonia, c. 500 B.C. European Cartography on the Eve of the Discoveries.

    ERIC Educational Resources Information Center

    Danzer, Gerald A.

    1991-01-01

    Discusses a cuneiform Babylonian tablet from about 500 B.C., the earliest extant world map. Explores bases for contemporary interpretation of the map. Observes that the map contains representations found in later maps. Suggests that modern views of the world are no less culturally laden than much earlier perspectives were. (SG)

  7. Genome Sequence of Radiation-Resistant Modestobacter marinus Strain BC501, a Representative Actinobacterium That Thrives on Calcareous Stone Surfaces

    PubMed Central

    Normand, Philippe; Gury, Jérôme; Pujic, Petar; Chouaia, Bessem; Crotti, Elena; Brusetti, Lorenzo; Daffonchio, Daniele; Vacherie, Benoit; Barbe, Valérie; Médigue, Claudine; Calteau, Alexandra; Ghodhbane-Gtari, Faten; Essoussi, Imen; Nouioui, Imen; Abbassi-Ghozzi, Ines

    2012-01-01

    Here we report the full genome sequence of Modestobacter marinus strain BC501, an actinobacterial isolate that thrives on stone surfaces. The generated chromosome is circular, with a length of 5.57 Mb and a G+C content of 74.13%, containing 5,445 protein-coding genes, 48 tRNAs, and 3 ribosomal operons. PMID:22887672

  8. The QseBC Quorum Sensing System is Involved in Salmonella enterica serovar Typhimurium Colonization of the Swine Gastrointestinal Tract

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The response of bacteria to hormone-like, chemical molecules is termed quorum sensing, a mechanism for cell-to-cell communication that includes sensing the host environment. In the gastrointestinal tract, at least two quorum sensing molecules are present that activate the bacterial QseBC quorum sen...

  9. The Origi