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Sample records for 7th century human

  1. Kinship and Y-Chromosome Analysis of 7th Century Human Remains: Novel DNA Extraction and Typing Procedure for Ancient Material

    PubMed Central

    Vanek, Daniel; Saskova, Lenka; Koch, Hubert

    2009-01-01

    Aim To develop novel DNA extraction and typing procedure for DNA identification of the 7th century human remains, determine the familiar relationship between the individuals, estimate the Y-chromosome haplogroup, and compare the Y-chromosome haplotype with the contemporary populations. Methods DNA from preserved femur samples was extracted using the modified silica-based extraction technique. Polymerase chain reaction amplification was performed using human identification kits MiniFiler, Identifiler, and Y-filer and also laboratory-developed and validated Y-chromosome short tandem repeat (STR) pentaplexes with short amplicons. Results For 244A, 244B, 244C samples, full autosomal DNA profiles (15 STR markers and Amelogenin) and for 244D, 244E, 244F samples, MiniFiler profiles were produced. Y-chromosome haplotypes consisting of up to 24 STR markers were determined and used to predict the Y-chromosome haplogroups and compare the resulting haplotypes with the current population. Samples 244A, 244B, 244C, and 244D belong to Y-chromosome haplogroup R1b and the samples 244E and 244F to haplogroup G2a. Comparison of ancient haplotypes with the current population yielded numerous close matches with genetic distance bellow 2. Conclusion Application of forensic genetics in archaeology enables retrieving new types of information and helps in data interpretation. The number of successfully typed autosomal and Y-STR loci from ancient specimens in this study is one of the largest published so far for aged samples. PMID:19480023

  2. Medieval Armenian Costumes: A History of the Armenians from the 7th-14th Centuries.

    ERIC Educational Resources Information Center

    Soghikian, Juanita Will

    The booklet contains illustrations of 40 medieval Armenian costumes based upon statues and paintings of the 7th through the 14th centuries. Part of a series of seven instructional materials dealing with the history and culture of Armenian Americans, the booklet also provides a discussion of Armenian history and detailed descriptions of each…

  3. Medieval Armenian Costumes: A History of the Armenians from the 7th-14th Centuries.

    ERIC Educational Resources Information Center

    Soghikian, Juanita Will

    The booklet contains illustrations of 40 medieval Armenian costumes based upon statues and paintings of the 7th through the 14th centuries. Part of a series of seven instructional materials dealing with the history and culture of Armenian Americans, the booklet also provides a discussion of Armenian history and detailed descriptions of each…

  4. Massartu: The Observation of Astronomical Phenomena in Assyria (7th Century BC)

    NASA Astrophysics Data System (ADS)

    Fales, F. M.

    2011-06-01

    The term massartu is well attested in letters in cuneiform to and from the Neo-Assyrian court, written in the main in the 7th century BC. In itself, massartu is a general Akkadian term, meaning "watch, guard", but in the early 1st millennium BC it takes on two interesting semantic specializations, both of which are tied to the practical and political needs of the Assyrian empire. In astrological-astronomical terms, massartu denotes the wake, vigil, or watch for astronomical observations on the part of the court specialists: such a wake was required by the Assyrian king on a nightly basis, for the subsequent consultation of the vast compilation of omens called Enūma Anu Enlil, and the drawing of conclusions relating to the state of the empire and of the royal dynasty. Many interesting texts show us the workings of the massartu in the capital city Nineveh or in other cities of Mesopotamia. But massartu had also a wider meaning, "vigilance", which denoted the requirement, on the part of all the subjects of the king of Assyria, to keep their eyes and ears open, so as to be able to report to the king if anything untoward was taking place, whether in the capital city or in the most remote military outpost of the empire. Thus, in a way, the astrologers were expected to perform no more and no less than the collective duty of "vigilance" on behalf of the king-but with their eyes trained on the heavens, and in await for signs ultimately sent from the gods.

  5. Determination and validation of criteria to define hypercementosis in two medieval samples from France (Sains-en-Gohelle, AD 7th-17th century; Jau-Dignac-et-Loirac, AD 7th-8th century).

    PubMed

    d'Incau, Emmanuel; Couture, Christine; Crépeau, Natacha; Chenal, Fanny; Beauval, Cédric; Vanderstraete, Vincent; Maureille, Bruno

    2015-02-01

    The main aim of this article was to develop different visual criteria allowing for an objective definition of hypercementosis (cementum hyperplasia). This preliminary study must notably show how to better understand at a later stage the significance of its frequency as well as its aetiologies, especially in past populations. we set up a study protocol (macroscopic and photographic observations) on material consisting of 2 medieval samples from France (1) Sains-en-Gohelle sample-SG (AD 7th-17th century; 407 individuals; 5756 teeth observed, 319 with hypercementosis) which was used to develop the different criteria for defining hypercementosis (2) Jau-Dignac-et-Loirac sample-JDL (AD 7th-8th century; 55 individuals; 709 teeth observed, 24 with hypercementosis) which was used to test the reproducibility of the criteria. From our observations we formulated different inclusion criteria with which to define hypercementosis objectively (k intraobserver≥0.96; k interobserver≥0.63). We were able to distinguish moderate (1m) and marked (1M) forms of diffuse hypercementosis, focal hypercementosis in the form of small knots (2m) or large nodules (2M), or excrescences in the form of ridges (3m) or spurs (3M). Different exclusion criteria were also determined. The definition that we propose in this study are based on various statistically validated inclusion and exclusion criteria. It is hoped that this will improve the significance of hypercementosis. More generally, this would also give a better understanding of the dynamics of cementum apposition. Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. [A development of Byzantine Christian charities during the 4(th)-7(th) centuries and the birth of the hospital].

    PubMed

    Nam, Sung Hyun

    2015-04-01

    This study aims to examine the beginning and the development of Christian Charities during the 4(th)-6(th) centuries which would eventually result in the birth of the hospital in modern sense in the first half of the 7(th) century. For this purpose, I looked carefully into various primary sources concerning the early Christian institutions for the poor and the sick. Above all, it's proper to note that the first xenodocheion where hospitality was combined with a systematic caring, is concerned with the Trinitarian debate of the 4(th) century. In 356, Eustathios, one of the leaders of homoiousios group, established xenodocheion to care for the sick and the lepers in Sebaste of Armenia, whereas his opponent Aetios, doctor and leader of the heteroousios party, was reckoned to have combined the medical treatment with his clerical activities. Then, Basil of Caesarea, disciple of Eustathios of Sebaste, also founded in 372 a magnificent benevolent complex named 'Basileias' after its founder. I scrupulously analysed several contemporary materials mentioning the charitable institution of Caesarea which was called alternatively katagogia, ptochotropheion, xenodocheion. John Chrysostome also founded several nosokomeia in Constantinople at the end of the 4(th) century and the beginning of the 5(th) century. Apparently, the contemporary sources mention that doctors existed for these Charities, but there is no sufficient proof that these 'Christian Hospitals,' Basileias or nosokomeia of Constantinople were hospitals in modern sense. Imperial constitutions began to mention ptochotropheion, xenodocheion and orphanotropheion since the second half of the 5(th) century and then some Justinian laws evoked nosokomium, brephotrophia, gerontocomia. These laws reveal that 'Christian Hospitals' were well clarified and deeply rooted in Byzantine society already in these periods. And then, new benevolent institutions emerged in the 6(th) century: nosokomeia for a specific class and

  7. Alloy characterization of a 7th Century BC archeological bronze vase - Overcoming patina constraints using Monte Carlo simulations

    NASA Astrophysics Data System (ADS)

    Manso, M.; Schiavon, N.; Queralt, I.; Arruda, A. M.; Sampaio, J. M.; Brunetti, A.

    2015-05-01

    In this work we evaluate the composition of a bronze alloy using X-ray fluorescence spectrometry (XRF) and Monte Carlo (MC) simulations. For this purpose, a 7th Century BC archeological vase from the SW Iberian Peninsula, displaying a well formed corrosion patina was analyzed by means of a portable X-ray fluorescence spectrometer. Realistic MC simulations of the experimental setup were performed with the XRMC code package which is based on an intensive use of variance-reduction techniques and uses XRAYLIB a constantly updated X-ray library of atomic data. A single layer model was applied for simulating XRF of polished/pristine bronze whereas a two-or-three-layer model was developed for bronze covered respectively by a corrosion patina alone or coupled with a superficial soil derived crust. These simulations took into account corrosion (cerussite (PbCO3), cuprite (Cu2O), malachite (Cu2CO3(OH)2), litharge (PbO)) and soil derived products (goethite (FeO(OH)) and quartz (SiO2)) identified by means of X-ray diffraction and Raman micro analytical techniques. Results confirm previous research indicating that the XRF/Monte Carlo protocol is well suited when a two-layered model is considered, whereas in areas where the patina + soil derived products' crust is too thick, X-rays from the alloy substrate are not able to exit the sample. Quantitative results based on MC simulations indicate that the vase is made of a lead-bronze alloy: Mn (0.2%), Fe (1.0%), Cu (81.8%), As (0.5%), Ag (0.6%), Sn (8.0%) and Pb (8.0%).

  8. Obsessions from the past: a study of the chapter on "blasphemous thoughts" in "The Ladder of Divine Ascent" (7th century AD).

    PubMed

    Avgoustidis, Adamantios G

    2013-12-01

    In this study, we examine the similarities and the differences between obsessions and the phenomena described in religious language as "blasphemous thoughts". The basis of our study is an ascetic text of the 7th century AD, entitled "The Ladder of Divine Ascent", written by Saint John Climacus (ca. 579-649), abbot of St. Catherine Monastery, Sinai. The book is considered to be one of the fundamental sources of monastic literature, which has influenced Christian anthropology. Research on the "Ladder" gives an insight in where the religious and the psychiatric pathogenic, diagnostic and therapeutic approaches converge or diverge. In addition to the scientific value, the data derived from the research could be useful to the therapist, especially when he/she copes with religious patients, in order to acquire a better empathy and thus lesser the patient's resistance toward therapy. Copyright © 2013. Published by Elsevier B.V.

  9. Cancer and its Treatment in Main Ancient Books of Islamic Iranian Traditional Medicine (7th to 14th Century AD)

    PubMed Central

    Emami, Seyed Ahmad; Sahebkar, Amirhossein; Tayarani-Najaran, Nilufar; Tayarani-Najaran, Zahra

    2012-01-01

    Abstract Islamic medicine is regarded as a comprehensive medical school with a long, glorious and worldwide reputation. Some of the physicians of this school are famous worldwide and have contributed valuable services to the scientific world. Given the dramatically increasing prevalence of cancer and the relative inefficacy of current medications, there is a great demand for the introduction of effective therapeutic approaches. To this end, integration of traditional medicine with modern medical treatments represents a promising option. In this essay, methods of diagnosis and treatment of cancer have been mentioned from the viewpoint of five famous physicians before the Mongolian attack who used Islamic medicine, namely Rhazes, Akhaveyni, Ahwazi, Avicenna and Jorjani. The ideas discussed dates back to a period between the eighth and fourteenth centuries. PMID:23482830

  10. Experimental Reservoirs of Human Pathogens: The Vibrio Cholerae Paradigm (7th Annual SFAF Meeting, 2012)

    SciTech Connect

    Colwell, Rita

    2012-06-01

    Rita Colwell on "Experimental Reservoirs of Human Pathogens: The Vibrio cholerae paradigm" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

  11. Experimental Reservoirs of Human Pathogens: The Vibrio Cholerae Paradigm (7th Annual SFAF Meeting, 2012)

    ScienceCinema

    Colwell, Rita [University of Maryland

    2016-07-12

    Rita Colwell on "Experimental Reservoirs of Human Pathogens: The Vibrio cholerae paradigm" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

  12. Industry Initiated Core Safety Attributes for Human Spaceflight for the 7th IAASS Conference

    NASA Technical Reports Server (NTRS)

    Mango, Edward J.

    2014-01-01

    Now that the NASA Commercial Crew Program (CCP) is beginning its full certification contract for crew transportation to the International Space Station (ISS), is it time for industry to embrace a minimum set of core safety attributes? Those attributes can then be evolved into an industry-led set of basic safety standards and requirements. After 50 years of human space travel sponsored by governments, there are two basic conditions that now exist within the international space industry. The first, there is enough of a space-faring history to encourage the space industry to design, develop and operate human spaceflight systems without government contracts for anything other than services. Second, industry is capable of defining and enforcing a set of industry-based safety attributes and standards for human spaceflight to low-Earth orbit (LEO). This paper will explore both of these basic conditions with a focus on the safety attributes and standards. In the United States, the Federal Aviation Administration (FAA) is now starting to dialogue with industry about the basic safety principles and attributes needed for potential future regulatory oversight. This process is not yet formalized and will take a number of years once approval is given to move forward. Therefore, throughout the next few years, it is an excellent time and opportunity for industry to collaborate together and develop the core set of attributes and standards. As industry engages and embraces a common set of safety attributes, then government agencies, like the FAA and NASA can use that industry-based product to strengthen their efforts on a safe commercial spaceflight foundation for the future. As the commercial space industry takes the lead role in establishing core safety attributes, and then enforcing those attributes, the entire planet can move away from governmental control of design and development and let industry expand safe and successful space operations in LEO. At that point the

  13. Identification, Geochemical Characterisation and Significance of Bitumen among the Grave Goods of the 7th Century Mound 1 Ship-Burial at Sutton Hoo (Suffolk, UK)

    PubMed Central

    Bowden, Stephen A.; Hacke, Marei; Parnell, John

    2016-01-01

    The 7th century ship-burial at Sutton Hoo is famous for the spectacular treasure discovered when it was first excavated in 1939. The finds include gold and garnet jewellery, silverware, coins and ceremonial armour of broad geographical provenance which make a vital contribution to understanding the political landscape of early medieval Northern Europe. Fragments of black organic material found scattered within the burial were originally identified as ‘Stockholm Tar’ and linked to waterproofing and maintenance of the ship. Here we present new scientific analyses undertaken to re-evaluate the nature and origin of these materials, leading to the identification of a previously unrecognised prestige material among the treasure: bitumen from the Middle East. Whether the bitumen was gifted as diplomatic gesture or acquired through trading links, its presence in the burial attests to the far-reaching network within which the elite of the region operated at this time. If the bitumen was worked into objects, either alone or in composite with other materials, then their significance within the burial would certainly have been strongly linked to their form or purpose. But the novelty of the material itself may have added to the exotic appeal. Archaeological finds of bitumen from this and earlier periods in Britain are extremely rare, despite the abundance of natural sources of bitumen within Great Britain. This find provides the first material evidence indicating that the extensively exploited Middle Eastern bitumen sources were traded northward beyond the Mediterranean to reach northern Europe and the British Isles. PMID:27906999

  14. Analysis of ethnoveterinary treatments for cattle (Bos indicus) diseases referred in Sanrimgyeongje including twelve volumes of literature from the 7th to the 18th century.

    PubMed

    Song, Mi-Jang; Kim, Hyun

    2011-01-27

    This study aims at a comprehensive analysis of ethnoveterinary treatment in the cattle-raising section of Sanrimgyeongje which covers 12 different volumes of literature including 4 Korean and 8 Chinese literatures from the 7th to the 18th century, with a special attention to the treatments for cattle diseases. The above mentioned literature was analyzed through several steps: translation of the Chinese text into Korean, identification of diseases, verification of medicinal materials and confirmation of scientific names. As recorded in the thirteen references, this study shows that there are 143 medicinal materials which have been used as therapies for cattle diseases. Of these, 55 plant species belonging to 52 genera in 29 families had 100 modes of usages, while one species of fungus was used in one way. Likewise, 11 species of animals belonging to 11 genera in 10 families were utilized in 18 different methods. Lastly, 9 kinds of inorganic matters were used in 11 ways with another 4 kinds being useful in 14 different ways. Consequently, each of rinderpests, murrains, and hooves has been treated, respectively with 14, 10 and 3 types of medicinal decoctions made from 35, 18 and 15 kinds of medicinal materials. This diversified usage of various medicinal materials is incomparable to the modern ethnoveterinary investigation which tends to focus strictly in plants. If additional studies were to be conducted on these treatments and all the medicinal materials used within them, various new treatments and medicines can be developed to supplement the pharmacopoeia of contemporary veterinary medicine. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  15. Annual Conference on Human Retrovirus Testing (7th) held in Chicago, IL on March 3-5, 1992

    DTIC Science & Technology

    1993-04-05

    Human T- Lymphotropic Viruses Types Leanna Durgin, Richard T Schumacher I and II * Eugene Robertson. Anne Chang. Michelle Edwards, Peggy Guidinger...Assays for Human Immunodeficiency Virus Antibodies in Dried Blood Specimens 0 Frances Pouch Downes. Louis Guskey 46 Comparison of HIV- 1 Serological...algorithm for use with Seventh Annual Conference on Human combination IIIV- 1 /2 [IA kits. Retrovirus Testing, sponsored by the Association Panel Session II

  16. Ion Torren Semiconductor Sequencing Allows Rapid, Low Cost Sequencing of the Human Exome ( 7th Annual SFAF Meeting, 2012)

    SciTech Connect

    Jenkins, David

    2012-06-01

    David Jenkins on "Ion Torrent semiconductor sequencing allows rapid, low-cost sequencing of the human exome" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

  17. Ion Torren Semiconductor Sequencing Allows Rapid, Low Cost Sequencing of the Human Exome ( 7th Annual SFAF Meeting, 2012)

    ScienceCinema

    Jenkins, David [EdgeBio

    2016-07-12

    David Jenkins on "Ion Torrent semiconductor sequencing allows rapid, low-cost sequencing of the human exome" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

  18. "Half a Century of Evolution of Neonatology: A Witness's Story" : Dr. K. C. Chaudhuri Lifetime Achievement Award Oration Delivered at AIIMS, New Delhi on 7th September 2014.

    PubMed

    Vidyasagar, Dharmapuri

    2015-12-01

    Lifetime achievement awards are awarded to recognize contributions during the career of an individual, rather than for a single or multiple contributions of a person in his/her field of specialty. I am highly honored being the recipient of the Dr. K. C. Chaudhuri Lifetime Achiement Award Oration. The award for me is significant for several reasons: First being associated with legendary figure such as Dr. Chaudhuri, secondly being recognized by my fellow Indian colleagues. Finally, it also marks half a century of my experience in development of subspecialty of neonatology in US. Some fifty and odd years ago, as an young novice from India I joined the mainstream of this evolution, thanks to my professors and mentors in US and thanks to America, the land of opportunity. During this odyssey, I met many great men and women of science and intellect, saw great scientific discoveries, many innovations, combined with social changes that led to significant reduction of neonatal mortality rates in the industrialized Western countries. I also saw the "Globalization" of "Modern Neonatology" in which I participated with vigor; thus, improving the newborn care in four corners of the world. I am proud that I had the opportunity to contribute a little to growth of neonatology in US and outside the US. This is the story of my professional life. The message of my life story for the younger generation is : Dream big, never give up your dreams. Hardwork, maintaining your integrity, and honesty are the three precepts that will define your character and you will be rewarded in the long run.

  19. Development of the Human Biceps Brachii Tendon and Coracoglenoid Ligament (7th-12th Week of Development).

    PubMed

    de la Cuadra-Blanco, Crótida; Arráez-Aybar, Luis A; Murillo-González, Jorge A; Herrera-Lara, Manuel E; Mérida-Velasco, Juan A; Mérida-Velasco, José R

    2017-01-01

    The goal of this study is to clarify the development of the long head of the biceps brachii tendon (LHBT) and to verify the existence and development of the coracoglenoid ligament. Histological preparations of 22 human embryos (7-8 weeks of development) and 43 human fetuses (9-12 weeks of development) were studied bilaterally using a conventional optical microscope. The articular interzone gives rise to the LHBT, glenoid labrum, and articular capsule. During the fetal period, it was observed that in 50 cases (58%), the LHBT originated from both the glenoid labrum and the scapula, while in 36 cases (42%), it originated only from the glenoid labrum. The coracoglenoid ligament, first described by Sappey in 1867, is a constant structure that originates at the base of the coracoid process and projects toward the glenoid labrum zone, which is related to the origin of the LHBT. The coracoglenoid ligament was more easily identifiable in the 36 cases in which the LHBT originated only from the glenoid labrum. We suggest that the coracoglenoid ligament is a constant anatomical structure, is not derived from the articular interzone unlike the LHBT, and contributes to the fixation of the glenoid labrum in the scapula in cases in which the LHBT originated only from the glenoid labrum. We postulate that, when the LHBT is fixed only at the glenoid labrum, alterations in the coracoglenoid ligament could lead to a less sufficient attachment of the glenoid labrum to the scapula which could predispose to a superior labral lesion. © 2017 S. Karger AG, Basel.

  20. 7th International Meshing Roundtable '98

    SciTech Connect

    Eldred, T.J.

    1998-10-01

    The goal of the 7th International Meshing Roundtable is to bring together researchers and developers from industry, academia, and government labs in a stimulating, open environment for the exchange of technical information related to the meshing process. In the past, the Roundtable has enjoyed significant participation from each of these groups from a wide variety of countries.

  1. Fundamentals of Physics, Extended 7th Edition

    NASA Astrophysics Data System (ADS)

    Halliday, David; Resnick, Robert; Walker, Jearl

    2004-05-01

    No other book on the market today can match the 30-year success of Halliday, Resnick and Walker's Fundamentals of Physics! Fundamentals of Physics, 7th Edition and the Extended Version, 7th Edition offer a solid understanding of fundamental physics concepts, helping readers apply this conceptual understanding to quantitative problem solving, in a breezy, easy-to-understand style. A unique combination of authoritative content and stimulating applications. * Numerous improvements in the text, based on feedback from the many users of the sixth edition (both instructors and students) * Several thousand end-of-chapter problems have been rewritten to streamline both the presentations and answers * 'Chapter Puzzlers' open each chapter with an intriguing application or question that is explained or answered in the chapter * Problem-solving tactics are provided to help beginning Physics students solve problems and avoid common error * The first section in every chapter introduces the subject of the chapter by asking and answering, "What is Physics?" as the question pertains to the chapter * Numerous supplements available to aid teachers and students The extended edition provides coverage of developments in Physics in the last 100 years, including: Einstein and Relativity, Bohr and others and Quantum Theory, and the more recent theoretical developments like String Theory.

  2. Highlights from the 7th European meeting on molecular diagnostics.

    PubMed

    Loonen, Anne Jm; Schuurman, Rob; van den Brule, Adriaan Jc

    2012-01-01

    This report presents the highlights of the 7th European Meeting on Molecular Diagnostics held in Scheveningen, The Hague, The Netherlands, 12-14 October 2011. The areas covered included molecular diagnostics applications in medical microbiology, virology, pathology, hemato-oncology, clinical genetics and forensics. Novel real-time amplification approaches, novel diagnostic applications and new technologies, such as next-generation sequencing, PCR electrospray-ionization TOF mass spectrometry and techniques based on the detection of proteins or other molecules, were discussed. Furthermore, diagnostic companies presented their future visions for molecular diagnostics in human healthcare.

  3. 7th Annual European Antibody Congress 2011

    PubMed Central

    2012-01-01

    The 7th European Antibody Congress (EAC), organized by Terrapin Ltd., was again held in Geneva, Switzerland, following on the tradition established with the 4th EAC. The 2011 version of the EAC was attended by nearly 250 delegates who learned of the latest advances and trends in the global development of antibody-based therapeutics. The first day focused on advances in understanding structure-function relationships, choosing the best format, glycoengineering biobetter antibodies, improving the efficacy and drugability of mAbs and epitope mapping. On the second day, the discovery of novel targets for mAb therapy, clinical pipeline updates, use of antibody combinations to address resistance, generation and identification of mAbs against new targets and biosimilar mAb development were discussed. Antibody-drug conjugates, domain antibodies and new scaffolds and bispecific antibodies were the topics of the third day. In total, nearly 50 speakers provided updates of programs related to antibody research and development on-going in the academic, government and commercial sectors. PMID:22453093

  4. [Effect of artificial skull deformation in vitro on sensory performance in the human. Morphologic and tomographic study based on the calvarium E2 of Tell es Sultan/Jericho (7th millenium b.c.)].

    PubMed

    Röhrer-Ertl, O; Frey, K W

    1984-01-01

    The question of an influence of artificial skull deformations on sensory performances in man has been discussed since Torquemada (1615). It was inquired into by means of the individual E2 of the Tell es Sultan/Jericho (7th millenium B.C.). At first a morphological expert evidence and then an ear tomography (Mündnich and Frey's method) were carried out. Hereby abnormal displacements of all head organs or their parts could be seen. Evaluable pathological findings, however, did not result. Thus an influence of artificial skull deformation on sensory performance in man has to be refused in the same way as the connection of the same with infant mortality invented by Torquemada (in this case political reasons were probably responsible for it). The functional thesis of Toldt for the formation of Arcus superciliares etc. was confirmed.

  5. A 21st-Century Humanities for the Community College

    ERIC Educational Resources Information Center

    Alford, Barry; Elden, Lucia

    2013-01-01

    This essay examines not only the role the humanities play in the community college curriculum but also how our approach to and understanding of the humanities must change. The defense of a 21st-century humanities has to begin in the experience of our students and not in the traditional canons of our disciplines.

  6. A 21st-Century Humanities for the Community College

    ERIC Educational Resources Information Center

    Alford, Barry; Elden, Lucia

    2013-01-01

    This essay examines not only the role the humanities play in the community college curriculum but also how our approach to and understanding of the humanities must change. The defense of a 21st-century humanities has to begin in the experience of our students and not in the traditional canons of our disciplines.

  7. Nuclear Medicine Physics: The Basics. 7th ed.

    PubMed

    Mihailidis, Dimitris

    2012-10-01

    Nuclear Medicine Physics: The Basics. 7th ed. Ramesh Chandra, Lippincott Williams and Wilkins, a Wolters Kluwer Business. Philadelphia, 2012. Softbound, 224 pp. Price: $69.99. ISBN: 9781451109412. © 2012 American Association of Physicists in Medicine.

  8. 7th International Immunoglobulin Conference: Immunomodulation

    PubMed Central

    Danieli, M G; Shoenfeld, Y

    2014-01-01

    Rheumatoid arthritis (RA) is a debilitating autoimmune disease that is usually treated aggressively to slow the rate of joint destruction. The therapeutic strategy used at the French centre, described here, is to use the non-biological disease-modifying drug, methotrexate, as first-line therapy and to add biological agents as second-line treatment. The two other autoimmune diseases discussed in this session were immunobullous skin diseases, and secondary recurrent miscarriage (RM). In the former conditions, low levels of pathogenic autoantibodies can be achieved with adjuvant intravenous immunoglobulin (IVIg) therapy, usually in combination with an immunosuppressant. Secondary RM has an autoimmune basis, as shown by high tumour necrosis factor (TNF)-α levels and specific human leucocyte antigen (HLA) polymorphisms. Although the mechanism is not yet known, IVIg may also be an effective treatment, despite the generally low doses used in published studies. PMID:25546788

  9. 7th International Immunoglobulin Conference: Interlaken Leadership Awards.

    PubMed

    Dalakas, M C; Löscher, W N

    2014-12-01

    The Interlaken Leadership Awards (ILAs), established in 2010, are monetary grants pledged annually by CSL Behring to fund research into the use of immunoglobulin (Ig) therapy, especially into its use in neurological disorders. Five recipients of the 2011/2012 Awards were invited to present their research at the 7th International Immunoglobulin Conference. Dr Honnorat reports on paraneoplastic neurological syndromes (PNS). His multi-centre Phase II trial, currently under way, will assess the efficacy of IVIg therapy in treating PNS in the first 3 months of treatment. Dr Geis shows improved disease scores after IVIg treatment in a mouse model of neuromyelitis optica (NMO). It is hoped that these promising results will translate well into human NMO. Dr Schmidt studied IVIg therapy in an mdx mouse model for Duchenne muscular dystrophy (DMD). He reports that motor function improved and myopathic changes in skeletal muscles and creatine kinase release were decreased. Dr Gamez presents the design and rationale for a Phase II clinical trial investigating the preoperative use of IVIg therapy in myasthenia gravis patients to prevent post-operative myasthenic crisis. Dr Goebel reports results from studies elucidating the immune-mediated pathogenesis of complex regional pain syndrome (CRPS), the successful IVIg therapy in a proportion of CRPS patients, and the development of a model for predicting which patients are more likely to respond to Ig therapy.

  10. Concept Mapping Improves Metacomprehension Accuracy among 7th Graders

    ERIC Educational Resources Information Center

    Redford, Joshua S.; Thiede, Keith W.; Wiley, Jennifer; Griffin, Thomas D.

    2012-01-01

    Two experiments explored concept map construction as a useful intervention to improve metacomprehension accuracy among 7th grade students. In the first experiment, metacomprehension was marginally better for a concept mapping group than for a rereading group. In the second experiment, metacomprehension accuracy was significantly greater for a…

  11. 7th meeting of the global arthritis research network

    PubMed Central

    2011-01-01

    Last October, the 7th meeting of the Global Arthritis Research Network was held in Zurich, Switzerland. European and American experts who have made major recent contributions to molecular biology got together to provide insights into novel technologies and approaches useful for biomedical research, especially for research on arthritis and related conditions. PMID:21892971

  12. Report of the Quadrennial Review of Military Compensation (7th)

    DTIC Science & Technology

    1992-08-21

    the matter is deeper, involv- The 7th QRMC reviewed the literature dealing ing policy choices between providing allowances or with the relationship...Report of the Seventh Quadrennial Review of Military Compensation AUGUST. 21 1992 DTIC gf ELECTE M AY 27 1993 D -1)Ijj~iiI@.1z OF 7T pi oe im i...COVERED 21 AUG 92 Final -- _ _ 4. TITLE AND SUBTITLE 5. FUNDING NUMBERS Report of the Seventh Quadrennial Review of Military Compensation ~ngaae’r

  13. JPRS Report, Science & Technology, Japan, 7th Artificial Intelligence Symposium.

    DTIC Science & Technology

    1988-09-14

    294030 JPRS-JST-88-020 14 SEPTEMBER 1988 ■■■■■I ■■■■■fl FOREIGN BROADCAST INFORMATION SERVICE , JPRS Report— Science & Technology Japan...INSPECTED 6 SPRINGFIELD, VA. 22161 JPRS-JST-88-020 14 SEPTEMBER 1988 SCIENCE & TECHNOLOGY JAPAN 7th ARTIFICIAL INTELLIGENCE SYMPOSIUM...43063809a Tokyo DAINANAKAI CHISHIKI KOGAKU SYMPOSIUM in Japanese 22-23 Mar 88 pp 1-6 [Article by Shigenbu Kobayashi, Tokyo Institute of Technology , and

  14. Plague: the dreadful visitation occupying the human mind for centuries.

    PubMed

    Khan, Iqbal Akhtar

    2004-05-01

    Plague is one of mankind's greatest scourges, which has swept away millions of people over the centuries. The first available record of the occurrence of this calamity, in humans, is from the Bible, in 1000 bc, in the city of Ashdod. The first definitely identified pandemic originated in Egypt in ad 542 (the Justinian Plague) and is estimated to have caused 100 million deaths. The second one, lasting for three centuries and claiming over 25 million lives appeared in 1334 in China spreading to many spots on the globe. The third pandemic occurred in Europe from the fifteenth to eighteenth century. The current pandemic began around 1860, in the Chinese province Yunnan; it reached Hong Kong in 1894 killing 100 000 individuals. Within 20 years the disease spread from southern Chinese ports throughout the world resulting in more than 10 million deaths. Since the discovery of the causative agent in 1894, there have been remarkable advancements in immunoprophylaxis and chemoprophylaxis. However, the disease is still active in Africa, in Asia and in Americas and has been classified as a currently re-emerging disease. A 'Plague-free World' will probably remain a dream for an indefinite period.

  15. Reimagining Human Research Protections for 21st Century Science

    PubMed Central

    Bietz, Matthew; Bae, Deborah; Bigby, Barbara; Devereaux, Mary; Fowler, James; Waldo, Ann; Weibel, Nadir; Patrick, Kevin; Klemmer, Scott; Melichar, Lori

    2016-01-01

    Background Evolving research practices and new forms of research enabled by technological advances require a redesigned research oversight system that respects and protects human research participants. Objective Our objective was to generate creative ideas for redesigning our current human research oversight system. Methods A total of 11 researchers and institutional review board (IRB) professionals participated in a January 2015 design thinking workshop to develop ideas for redesigning the IRB system. Results Ideas in 5 major domains were generated. The areas of focus were (1) improving the consent form and process, (2) empowering researchers to protect their participants, (3) creating a system to learn from mistakes, (4) improving IRB efficiency, and (5) facilitating review of research that leverages technological advances. Conclusions We describe the impetus for and results of a design thinking workshop to reimagine a human research protections system that is responsive to 21st century science. PMID:28007687

  16. Fundamentals of Physics, Student Study Guide, Extended 7th Edition

    NASA Astrophysics Data System (ADS)

    Halliday, David; Resnick, Robert; Walker, Jearl

    2004-06-01

    No other book on the market today can match the 30-year success of Halliday, Resnick and Walker's Fundamentals of Physics! Fundamentals of Physics, 7th Edition and the Extended Version, 7th Edition offer a solid understanding of fundamental physics concepts, helping readers apply this conceptual understanding to quantitative problem solving, in a breezy, easy-to-understand style. A unique combination of authoritative content and stimulating applications. * Numerous improvements in the text, based on feedback from the many users of the sixth edition (both instructors and students) * Several thousand end-of-chapter problems have been rewritten to streamline both the presentations and answers * 'Chapter Puzzlers' open each chapter with an intriguing application or question that is explained or answered in the chapter * Problem-solving tactics are provided to help beginning Physics students solve problems and avoid common error * The first section in every chapter introduces the subject of the chapter by asking and answering, "What is Physics?" as the question pertains to the chapter * Numerous supplements available to aid teachers and students The extended edition provides coverage of developments in Physics in the last 100 years, including: Einstein and Relativity, Bohr and others and Quantum Theory, and the more recent theoretical developments like String Theory.

  17. Detection of human influence on twentieth-century precipitation trends.

    PubMed

    Zhang, Xuebin; Zwiers, Francis W; Hegerl, Gabriele C; Lambert, F Hugo; Gillett, Nathan P; Solomon, Susan; Stott, Peter A; Nozawa, Toru

    2007-07-26

    Human influence on climate has been detected in surface air temperature, sea level pressure, free atmospheric temperature, tropopause height and ocean heat content. Human-induced changes have not, however, previously been detected in precipitation at the global scale, partly because changes in precipitation in different regions cancel each other out and thereby reduce the strength of the global average signal. Models suggest that anthropogenic forcing should have caused a small increase in global mean precipitation and a latitudinal redistribution of precipitation, increasing precipitation at high latitudes, decreasing precipitation at sub-tropical latitudes, and possibly changing the distribution of precipitation within the tropics by shifting the position of the Intertropical Convergence Zone. Here we compare observed changes in land precipitation during the twentieth century averaged over latitudinal bands with changes simulated by fourteen climate models. We show that anthropogenic forcing has had a detectable influence on observed changes in average precipitation within latitudinal bands, and that these changes cannot be explained by internal climate variability or natural forcing. We estimate that anthropogenic forcing contributed significantly to observed increases in precipitation in the Northern Hemisphere mid-latitudes, drying in the Northern Hemisphere subtropics and tropics, and moistening in the Southern Hemisphere subtropics and deep tropics. The observed changes, which are larger than estimated from model simulations, may have already had significant effects on ecosystems, agriculture and human health in regions that are sensitive to changes in precipitation, such as the Sahel.

  18. Human Hookworm Infection in the 21st Century

    PubMed Central

    Brooker, Simon; Bethony, Jeffrey; Hotez, Peter J.

    2008-01-01

    The scientific study of human hookworm infection began at the dawn of the twentieth century. In recent years, there have been dramatic improvements in our understanding of many aspects of this globally widespread parasite. This article reviews recent advances in our understanding in the biology, immunology, epidemiology, public health significance and control of hookworm, and to look forward to the study of this important parasite in the 21st century. Advances in molecular biology has lead to the identification of a variety of new molecules from hookworms, which have importance either in the molecular pathogenesis of hookworm infection or in the host-parasite relationship; some are also promising vaccine targets. At present, relatively little is known about the immune responses to hookworm infection, although it has recently been speculated that hookworm and other helminths may modulate specific immune responses to other pathogens and vaccines. Our epidemiological understanding of hookworm has improved through the development of mathematical models of transmission dynamics, which coupled with decades of field research across mutliple epidemiological settings, have shown that certain population characteristics can now be recognised as common to the epidemiology, population biology and control of hookworm and other helminth species. Recent recognition of the subtle, but significant, impact of hookworm on health and education, together with the simplicity, safety, low cost, and efficacy of chemotherapy has spurred international efforts to control the morbidity due to infection. Large-scale treatment programmes are currently underway, supported by health education and integrated with the provision of improved water and sanitation. There are also efforts underway to develop novel anthelmintic drugs and anti-hookworm vaccines. PMID:15603764

  19. Human hookworm infection in the 21st century.

    PubMed

    Brooker, Simon; Bethony, Jeffrey; Hotez, Peter J

    2004-01-01

    The scientific study of human hookworm infection began at the dawn of the twentieth century. In recent years, there have been dramatic improvements in our understanding of many aspects of this globally widespread parasite. This chapter reviews recent advances in our understanding in the biology, immunology, epidemiology, public health significance and control of hookworm, and to look forward to the study of this important parasite in the 21st century. Advances in molecular biology has lead to the identification of a variety of new molecules from hookworms, which have importance either in the molecular pathogenesis of hookworm infection or in the host-parasite relationship; some are also promising vaccine targets. At present, relatively little is known about the immune responses to hookworm infection, although it has recently been speculated that hookworm and other helminths may modulate specific immune responses to other pathogens and vaccines. Our epidemiological understanding of hookworm has improved through the development of mathematical models of transmission dynamics, which coupled with decades of field research across multiple epidemiological settings, have shown that certain population characteristics can now be recognised as common to the epidemiology, population biology and control of hookworm and other helminth species. Recent recognition of the subtle, but significant, impact of hookworm on health and education, together with the simplicity, safety, low cost and efficacy of chemotherapy has spurred international efforts to control the morbidity due to infection. Large-scale treatment programmes are currently underway, ideally supported by health education and integrated with the provision of improved water and sanitation. There are also on-going efforts to develop novel anthelmintic drugs and anti-hookworm vaccines.

  20. A 21st century roadmap for human health risk assessment.

    PubMed

    Pastoor, Timothy P; Bachman, Ammie N; Bell, David R; Cohen, Samuel M; Dellarco, Michael; Dewhurst, Ian C; Doe, John E; Doerrer, Nancy G; Embry, Michelle R; Hines, Ronald N; Moretto, Angelo; Phillips, Richard D; Rowlands, J Craig; Tanir, Jennifer Y; Wolf, Douglas C; Boobis, Alan R

    2014-08-01

    The Health and Environmental Sciences Institute (HESI)-coordinated Risk Assessment in the 21st Century (RISK21) project was initiated to develop a scientific, transparent, and efficient approach to the evolving world of human health risk assessment, and involved over 120 participants from 12 countries, 15 government institutions, 20 universities, 2 non-governmental organizations, and 12 corporations. This paper provides a brief overview of the tiered RISK21 framework called the roadmap and risk visualization matrix, and articulates the core principles derived by RISK21 participants that guided its development. Subsequent papers describe the roadmap and matrix in greater detail. RISK21 principles include focusing on problem formulation, utilizing existing information, starting with exposure assessment (rather than toxicity), and using a tiered process for data development. Bringing estimates of exposure and toxicity together on a two-dimensional matrix provides a clear rendition of human safety and risk. The value of the roadmap is its capacity to chronicle the stepwise acquisition of scientific information and display it in a clear and concise fashion. Furthermore, the tiered approach and transparent display of information will contribute to greater efficiencies by calling for data only as needed (enough precision to make a decision), thus conserving animals and other resources.

  1. Humanities: The Unexpected Success Story of the Twenty-First Century

    ERIC Educational Resources Information Center

    Davis, Virginia

    2012-01-01

    Humanities within universities faced challenges in the latter half of the twentieth century as their value in the modern world was questioned. This paper argues that there is strong potential for the humanities to thrive in the twenty-first century university sector. It outlines some of the managerial implications necessary to ensure that this…

  2. Humanities: The Unexpected Success Story of the Twenty-First Century

    ERIC Educational Resources Information Center

    Davis, Virginia

    2012-01-01

    Humanities within universities faced challenges in the latter half of the twentieth century as their value in the modern world was questioned. This paper argues that there is strong potential for the humanities to thrive in the twenty-first century university sector. It outlines some of the managerial implications necessary to ensure that this…

  3. Profile of mathematics anxiety of 7th graders

    NASA Astrophysics Data System (ADS)

    Udil, Patrisius Afrisno; Kusmayadi, Tri Atmojo; Riyadi

    2017-08-01

    Mathematics anxiety is one of the important factors affect students mathematics achievement. This present research investigates profile of students' mathematics anxiety. This research focuses on analysis and description of students' mathematics anxiety level generally and its dominant domain and aspect. Qualitative research with case study strategy was used in this research. Subject in this research involved 15 students of 7th grade chosen with purposive sampling. Data in this research were students' mathematics anxiety scale result, interview record, and observation result during both mathematics learning activity and test. They were asked to complete mathematics anxiety scale before interviewed and observed. The results show that generally students' mathematics anxiety was identified in the moderate level. In addition, students' mathematics anxiety during mathematics test was identified in the high level, but it was in the moderate level during mathematics learning process. Based on the anxiety domain, students have a high mathematics anxiety on cognitive domain, while it was in the moderate level for psychological and physiological domains. On the other hand, it was identified in low level for psychological domain during mathematics learning process. Therefore, it can be concluded that students have serious and high anxiety regarding mathematics on the cognitive domain and mathematics test aspect.

  4. 7th IGRSM International Remote Sensing & GIS Conference and Exhibition

    NASA Astrophysics Data System (ADS)

    Shariff, Abdul Rashid Mohamed

    2014-06-01

    IGRSM This proceedings consists of the peer-reviewed papers from the 7th IGRSM International Conference and Exhibition on Remote Sensing & GIS (IGRSM 2014), which was held on 21-22 April 2014 at Berjaya Times Square Hotel, Kuala Lumpur, Malaysia. The conference, with the theme Geospatial Innovation for Nation Building was aimed at disseminating knowledge, and sharing expertise and experiences in geospatial sciences in all aspects of applications. It also aimed to build linkages between local and international professionals in this field with industries. Highlights of the conference included: Officiation by Y B Datuk Dr Abu Bakar bin Mohamad Diah, Deputy Minister of Minister of Science, Technology & Innovation Keynote presentations by: Associate Professor Dr Francis Harvey, Chair of the Geographic Information Science Commission at the International Geographical Union (IGU) and Director of U-Spatial, University of Minnesota, US: The Next Age of Discovery and a Future in a Post-GIS World. Professor Dr Naoshi Kondo, Bio-Sensing Engineering, University of Kyoto, Japan: Mobile Fruit Grading Machine for Precision Agriculture. Datuk Ir Hj Ahmad Jamalluddin bin Shaaban, Director-General, National Hydraulic Research Institute of Malaysia (NAHRIM), Malaysia: Remote Sensing & GIS in Climate Change Analyses. Oral and poster presentations from 69 speakers, from both Malaysia (35) and abroad (34), covering areas of water resources management, urban sprawl & social mobility, agriculture, land use/cover mapping, infrastructure planning, disaster management, technology trends, environmental monitoring, atmospheric/temperature monitoring, and space applications for the environment. Post-conference workshops on: Space Applications for Environment (SAFE), which was be organised by the Japan Aerospace Exploration Agency (JAXA) Global Positioning System (GPS) Receiver Evaluation Using GPS Simulation, which was be organised by the Science & Technology Research Institute for Defence

  5. Seismological Aspects of the August 7th Zhouqu Debris Flows

    NASA Astrophysics Data System (ADS)

    Dan, Y.; Huang, X.

    2016-12-01

    Broadband seismic records have been proven to be a sufficient tool in extracting movement characteristics of debris flows in the last decades. The catastrophic Sanyanyu and Luojiayu debris flows, which were induced by a heavy rainfall, occurred at approximately the midnight of August 7th, 2010 (Beijing time, UTC+8) and claimed 1,765 lives. Broadband seismic signals recorded by the Zhouqu seismic station positioned only 150 meters away from the exit are acquired and analyzed in this study. Seismic signals reveal that the Sanyanyu debris flow started developing after a major rock collapse at approximately 23:23:50. The formation time of the Sanyanyu debris flow to separate its development stage and maturity stage was determined at 23:33:15 using spectrograms and amplitude variation patterns of seismic signals. Seismic signals, before and after the formation time, have distinctively different frequency characteristics. The frequency content of seismic signals generated by the maturity stage is more regular than that generated by the development stage. The maturity stage was further divided into five sub stages according to its amplitude variation patterns, including three increase sub stages and two stable sub stages alternately distributed. These five sub stages belong to two processes of the Sanyanyu debris flow which generate seismic signals with different frequency contents. The main frequency band of the first four sub stages continuously varies from approximately 2 - 8.5 Hz at start to approximately 3 - 9.5 Hz in the end. For the last sub stage, the upper boundary of the main frequency increases in a near linear way and reaches approximately 13 - 16 Hz in the end. Two sub stages are recognized from the satellite image of the Sanyanyu flow path, and the mean movement velocities of the Sanyanyu debris flow during these two sub stages are estimated to be 9.2 m/s and 9.7 m/s respectively.

  6. The 7th International Workshop on Chiral Dynamics

    NASA Astrophysics Data System (ADS)

    The 7th International Workshop Chiral Dynamics: Theory and Experiment (CD12) took place at Jefferson Lab, Newport News, Virginia, USA, from August 6 to 10, 2012. Following in the tradition of this triennial series of Conferences, it attracted theorists and experimentalists, who were brought together to highlight the recent progress in the field of low energy QCD, and to discuss and explore the direction for future development. The conference consisted of plenary talks and three working groups. We would like to thank the working group organizers for their dedicated effort, namely: Goldstone Bosons: Mario Antonelli, Liping Gan, Jorge Portoles and Urs Wenger; Hadron Structure: Alessandro Bacchetta, Bastian Kubis, Kostas Orginos and Karl Slifer and Few Body Physics: Andreas Nogga, Assumpta Parreno, Michele Viviani and Henry Weller. We would like to express our special thanks to our co-organizers, Patricia Solvignon, Harald Griesshammer, Rocco Schiavilla, Dinko Pocanic, Robert Edwards, and Alexandre Deur for their hard work and advice. Last but not least, we thank the International Advisory Committee for their very useful inputs to the CD12 program. The organizers thank the excellent logistic and administrative support provided by the Jefferson Lab Conference Staff, Ruth Bizot, Cynthia Lockwood, Stephanie Vermeire, Marti Hightower and MeLaina Evans, and the Conference Secretary Mary Fox, which was instrumental for the success of the organization of CD12. We thank Joanna Griffin for the poster design. CD12 was primarily sponsored by Jefferson Lab, along with generous supports from Old Dominion University and the European Physics Journal. The CD12 homepage is located at http://www.jlab.org/conference/CD12 The upcoming Chiral Dynamics Workshop will take place in Pisa, Italy, in 2015. We thank Laura Marcucci and Michele Viviani for graciously taking the baton from us. Jose Goity and Jianping Chen

  7. PREFACE: 7th European Conference on Applied Superconductivity (EUCAS '05)

    NASA Astrophysics Data System (ADS)

    Weber, Harald W.; Sauerzopf, Franz M.

    2006-07-01

    This issue of Journal of Physics: Conference Series contains those contributed papers that were submitted to the Conference Proceedings of the 7th European Conference on Applied Superconductivity (EUCAS '05) on 11 - 15 September 2005. The plenary and invited papers were published in the journal Superconductor Science and Technology 19 2006 (March issue). The scientific aims of EUCAS '05 followed the tradition established at the preceding conferences in Göttingen, Edinburgh, Eindhoven, Sitges (Barcelona), Lyngby (Copenhagen) and finally Sorrento (Napoli). The focus was placed on the interplay between the most recent developments in superconductor research and the positioning of applications of superconductivity in the marketplace. Although initially founded as an exchange forum mainly for European scientists, it has gradually developed into a truly international meeting with significant attendance from the Far East and the United States. The Vienna conference attracted 813 participants in the scientific programme and 90 guests: of the particpants 59% were from Europe, 31% from the Far East, 6% from the United States and Canada and 4% from other nations worldwide. There were 32 plenary and invited lectures highlighting the state-of-the-art in the areas of materials, large-scale and small-scale applications, and 625 papers were contributed (556 of these were posters) demonstrating the broad range of exciting activities in all research areas of our field. A total of 27 companies presented their most recent developments in the field. This volume contains 349 papers, among them 173 on materials (49.6%), 90 on large scale applications (25.8%) and 86 on small scale applications (24.6%). EUCAS '05 generated a feeling of optimism and enthusiasm for this fascinating field of research and for its well established technological potential, especially among the numerous young researchers attending this Conference. We are grateful to all those who participated in the meeting and

  8. PREFACE: 7th EEIGM International Conference on Advanced Materials Research

    NASA Astrophysics Data System (ADS)

    Joffe, Roberts

    2013-12-01

    The 7th EEIGM Conference on Advanced Materials Research (AMR 2013) was held at Luleå University of Technology on the 21-22 March 2013 in Luleå, SWEDEN. This conference is intended as a meeting place for researchers involved in the EEIGM programme, in the 'Erasmus Mundus' Advanced Materials Science and Engineering Master programme (AMASE) and the 'Erasmus Mundus' Doctoral Programme in Materials Science and Engineering (DocMASE). This is great opportunity to present their on-going research in the various fields of Materials Science and Engineering, exchange ideas, strengthen co-operation as well as establish new contacts. More than 60 participants representing six countries attended the meeting, in total 26 oral talks and 19 posters were presented during two days. This issue of IOP Conference Series: Materials Science and Engineering presents a selection of articles from EEIGM-7 conference. Following tradition from previous EEIGM conferences, it represents the interdisciplinary nature of Materials Science and Engineering. The papers presented in this issue deal not only with basic research but also with applied problems of materials science. The presented topics include theoretical and experimental investigations on polymer composite materials (synthetic and bio-based), metallic materials and ceramics, as well as nano-materials of different kind. Special thanks should be directed to the senior staff of Division of Materials Science at LTU who agreed to review submitted papers and thus ensured high scientific level of content of this collection of papers. The following colleagues participated in the review process: Professor Lennart Walström, Professor Roberts Joffe, Professor Janis Varna, Associate Professor Marta-Lena Antti, Dr Esa Vuorinen, Professor Aji Mathew, Professor Alexander Soldatov, Dr Andrejs Purpurs, Dr Yvonne Aitomäki, Dr Robert Pederson. Roberts Joffe October 2013, Luleå Conference photograph EEIGM7 conference participants, 22 March 2013 The PDF

  9. [Foods and drinks in a 19th century human physiology textbook].

    PubMed

    Chiancone, Francesco M

    2004-01-01

    The Author reports on the chapter of "Nutrition" in the Human Physiology textbook by P. Albertoni and A. Stefani published in the first half of the 19th century. This is one of the first textbooks that treats Physiology as an experimental science in contrast with the thinking of the previous century which was still dominated by Galen and Dioscorides.

  10. A century of trends in adult human height.

    PubMed

    2016-07-26

    Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5-22.7) and 16.5 cm (13.3-19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8-144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.

  11. A century of trends in adult human height

    PubMed Central

    2016-01-01

    Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5–22.7) and 16.5 cm (13.3–19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8–144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries. DOI: http://dx.doi.org/10.7554/eLife.13410.001 PMID:27458798

  12. Cyberspace, the 7th Joint Function for 21st Century Warfare

    DTIC Science & Technology

    2017-03-31

    NAME(S) AND ADDRESS(ES) 12. DISTRIBUTION/AVAILABILITY STATEMENT 13. SUPPLEMENTARY NOTES 14. ABSTRACT 15. SUBJECT TERMS 16. SECURITY CLASSIFICATION...OF: a. REPORT b. ABSTRACT c. THIS PAGE 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES 19a. NAME OF RESPONSIBLE PERSON...elsewhere such as: prepared in cooperation with; translation of; report supersedes; old edition number, etc. 14. ABSTRACT . A brief (approximately

  13. The art of human anatomy: Renaissance to 21st century.

    PubMed

    Van Hee, Robrecht; Wells, F C; Ballestriero, Roberta; Richardson, Ruth; Mazzarello, Paolo; Cani, Valentina; Catani, Marco

    2014-01-01

    This session examines the relationship between the art and science of anatomy from the time of Vesalius to the present with particular emphasis on the role of the medical artist and the changing nature of anatomical illustration over the last five centuries. Pivotal changes in the art of anatomy will be examined including the evolution of media and brain imaging from Golgi to Geschwind.

  14. Harvard Humanities Students Discover the 17th Century Online

    ERIC Educational Resources Information Center

    Howard, Jennifer

    2007-01-01

    This article profiles Harvard professor Stephen Greenblatt's new course, "Travel and Transformation in the Early 17th Century." The product of an intense, months-long collaboration between computing specialists, graduate students, librarians, and scholars, the course makes innovative use of all the tools and technical know-how a major university…

  15. Harvard Humanities Students Discover the 17th Century Online

    ERIC Educational Resources Information Center

    Howard, Jennifer

    2007-01-01

    This article profiles Harvard professor Stephen Greenblatt's new course, "Travel and Transformation in the Early 17th Century." The product of an intense, months-long collaboration between computing specialists, graduate students, librarians, and scholars, the course makes innovative use of all the tools and technical know-how a major university…

  16. Paving the Way for the 21st Century: The Human Factor in Higher Education Financial Management.

    ERIC Educational Resources Information Center

    Ginsburg, Sigmund G., Ed.

    This book presents human resources issues that will affect the financial management of colleges and universities as they move into the 21st century. It examines how business managers and human resources managers must balance human resources management policies and practices against the financial demands on the institution. It discusses the…

  17. 7th International Conference on Mathematical Methods in Physics

    NASA Astrophysics Data System (ADS)

    Bonora, L.; Bytsenko, A. A.; Guimarães, M. E. X.; Helayël-Neto, J. A.

    The 7th International Conference on Mathematical Methods in Physics took place in the Centro Brasileiro de Pesquisas Físicas (CBPF/MCT), Rio de Janeiro - RJ, Brazil, from 16 to 20 April 2012, and was jointly organized by the following Institutions: Centro Brasileiro de Pesquisas Físicas (CBPF/MCT), The Abdus Salam International Centre for Theoretical Physics (ICTP, Italy), Instituto Nacional de Matemática Pura e Aplicada (IMPA, Brazil), The Academy of Sciences for the Developing World (TWAS, Italy) and The Scuola Internazionale di Studi Avanzati (SISSA,Italy). The Organizing Committees were composed by: E. ABDALLA (USP, Brazil), L. BONORA (SISSA, Italy), H. BURSZTYN (IMPA, Brazil), A. A. BYTSENKO (UEL, Brazil), B. DUBROVIN (SISSA, Italy), M.E.X. GUIMARÃES (UFF, Brazil), J.A. HELAYËL-NETO (CBPF, Brazil). Advisory Committee: A. V. ASHTEKAR (Penn State University, U.S.A.), V. M. BUCHSTABER (Steklov Mathematical Institute, Russia), L. D. FADDEEV (St. Petersburg Dept. of Steklov Mathematical Institute, Russia), I. M. KRICHEVER (Columbia Univ., U.S.A./ Landau Institute of Theoretical Physics, Russia), S. P. NOVIKOV (Univ. of Maryland, U.S.A./Landau Institute of Theoretical Physics, Russia), J. PALIS (IMPA, Brazil), A. QADIR (National University of Sciences and Technology, Pakistan), F. QUEVEDO (ICTP, Italy), S. RANDJBAR-DAEMI (ICTP, Italy), G. THOMPSON (ICTP, Italy), C. VAFA (Harvard University, U.S.A.). The Main Goal: The aim of the Conference was to present the latest advances in Mathematical Methods of Physics to researchers, young scientists and students of Latin America in general, and Brazil in particular, in the areas of High Energy Physics, Cosmology, Mathematical Physics and Applied Mathematics. The main goal was to promote an updating of knowledge and to facilitate the interaction between mathematicians and theoretical physicists, through plenary sessions and seminars. This Conference can be considered as a part of a network activity in a special effort to

  18. 3. PHOTOGRAPHIC COPY OF MASTER PLAN, DETAIL SITE PLAN, 7TH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. PHOTOGRAPHIC COPY OF MASTER PLAN, DETAIL SITE PLAN, 7TH CAVALRY BUILDINGS, DATED SEPTEMBER 10, 1951, SEE ARROW, DRAWING # BM-036, COPY ON FILE IN THE ENVIRONMENTAL MANAGEMENT OFFICE, FORT BLISS - Fort Bliss, 7th Cavalry Buildings, U.S. Army Air Defence Artillery Center & Fort Bliss, El Paso, El Paso County, TX

  19. Association of Grade Configuration with School Climate for 7th and 8th Grade Students

    ERIC Educational Resources Information Center

    Malone, Marisa; Cornell, Dewey; Shukla, Kathan

    2017-01-01

    Educational authorities have questioned whether middle schools provide the best school climate for 7th and 8th grade students, and proposed that other grade configurations such as K-8th grade schools may provide a better learning environment. The purpose of this study was to compare 7th and 8th grade students' perceptions of 4 key features of…

  20. [Media for 21st century--towards human communication media].

    PubMed

    Harashima, H

    2000-05-01

    Today, with the approach of the 21st century, attention is focused on multi-media communications combining computer, visual and audio technologies. This article discusses the communication media target and the technological problems constituting the nucleus of multi-media. The communication media is becoming an environment from which no one can escape. Since the media has such a great power, what is needed now is not to predict the future technologies, but to estimate the future world and take to responsibility for future environments.

  1. Indirect human impacts reverse centuries of carbon sequestration and salt marsh accretion.

    PubMed

    Coverdale, Tyler C; Brisson, Caitlin P; Young, Eric W; Yin, Stephanie F; Donnelly, Jeffrey P; Bertness, Mark D

    2014-01-01

    Direct and indirect human impacts on coastal ecosystems have increased over the last several centuries, leading to unprecedented degradation of coastal habitats and loss of ecological services. Here we document a two-century temporal disparity between salt marsh accretion and subsequent loss to indirect human impacts. Field surveys, manipulative experiments and GIS analyses reveal that crab burrowing weakens the marsh peat base and facilitates further burrowing, leading to bank calving, disruption of marsh accretion, and a loss of over two centuries of sequestered carbon from the marsh edge in only three decades. Analogous temporal disparities exist in other systems and are a largely unrecognized obstacle in attaining sustainable ecosystem services in an increasingly human impacted world. In light of the growing threat of indirect impacts worldwide and despite uncertainties in the fate of lost carbon, we suggest that estimates of carbon emissions based only on direct human impacts may significantly underestimate total anthropogenic carbon emissions.

  2. Indirect Human Impacts Reverse Centuries of Carbon Sequestration and Salt Marsh Accretion

    PubMed Central

    Coverdale, Tyler C.; Brisson, Caitlin P.; Young, Eric W.; Yin, Stephanie F.; Donnelly, Jeffrey P.; Bertness, Mark D.

    2014-01-01

    Direct and indirect human impacts on coastal ecosystems have increased over the last several centuries, leading to unprecedented degradation of coastal habitats and loss of ecological services. Here we document a two-century temporal disparity between salt marsh accretion and subsequent loss to indirect human impacts. Field surveys, manipulative experiments and GIS analyses reveal that crab burrowing weakens the marsh peat base and facilitates further burrowing, leading to bank calving, disruption of marsh accretion, and a loss of over two centuries of sequestered carbon from the marsh edge in only three decades. Analogous temporal disparities exist in other systems and are a largely unrecognized obstacle in attaining sustainable ecosystem services in an increasingly human impacted world. In light of the growing threat of indirect impacts worldwide and despite uncertainties in the fate of lost carbon, we suggest that estimates of carbon emissions based only on direct human impacts may significantly underestimate total anthropogenic carbon emissions. PMID:24675669

  3. A Blind Giant: A Century of US Involvement in the Philippines and the Human Domain

    DTIC Science & Technology

    2016-06-01

    an answer: the Human Domain (HD). The HD comprises the study of those factors that influence human behavior. The HD, as a strategic concept, was...beginning to find operational merit in understanding the adversary’s organizational structure and the subsequent relationship to human behavior. Paul...A BLIND GIANT: A CENTURY OF US INVOLVEMENT IN THE PHILIPPINES AND THE HUMAN DOMAIN BY MAJOR KAVERI T. CRUM A THESIS PRESENTED TO

  4. "What Have the Humanities to Offer 21st-Century Europe?": Reflections of a Note Taker

    ERIC Educational Resources Information Center

    Parker, Jan

    2008-01-01

    The Humanities have much to offer 21st-century Europe, in terms of both method and issues which may complement and correct those of Science and Social Science. These include, for instance, humanities' generation of plural narratives and plural explanations, of attention to singularity and complexity, and to others' sensibilities and ways of…

  5. A 21st Century Roadmap for Human Health Risk Assessment

    EPA Science Inventory

    For decades human health risk assessment has depended primarily on animal testing to predict adverse effects in humans, but that paradigm has come under question because of calls for more accurate information, less use of animals, and more efficient use of resources. Moreover, t...

  6. Education as a Human Right in the 21st Century

    ERIC Educational Resources Information Center

    Lee, Sharon E.

    2013-01-01

    According to the United Nations, education is a right to which all human beings are entitled. Since 2000, the UN has been promoting the Millennium Development Goal to achieve free universal primary education for all, regardless of gender, by 2015. If the UN is correct to suggest that education is both a human right in itself and an indispensable…

  7. A 21st Century Roadmap for Human Health Risk Assessment

    EPA Science Inventory

    For decades human health risk assessment has depended primarily on animal testing to predict adverse effects in humans, but that paradigm has come under question because of calls for more accurate information, less use of animals, and more efficient use of resources. Moreover, t...

  8. A compositional study of a museum jewellery collection (7th-1st BC) by means of a portable XRF spectrometer

    NASA Astrophysics Data System (ADS)

    Karydas, A. G.; Kotzamani, D.; Bernard, R.; Barrandon, J. N.; Zarkadas, Ch.

    2004-11-01

    Within the framework of the project "Jewelmed" (ICA3-1999-10020), the chemical composition of 34 gold and four silver jewels was examined. These jewels belong to the Benaki museum's collection in Athens, Greece and are dating from the 7th to the 1st century BC. The compositional analysis of the jewels was performed by means of a "home-made" portable X-ray fluorescence (XRF) spectrometer. The XRF results have shown that the gold jewels can be categorized in two groups, which include artifacts made by native and by high purity gold, respectively. For the silver jewels the results have provided interesting information regarding the manufacturing technology, the authenticity of the jewels and the raw materials used. The potential and the limitations of the XRF technique, applied in the chemical analysis of archaeological metal artifacts, are also discussed.

  9. A 21st Century Roadmap for Human Health Risk Assessment ...

    EPA Pesticide Factsheets

    For decades human health risk assessment has depended primarily on animal testing to predict adverse effects in humans, but that paradigm has come under question because of calls for more accurate information, less use of animals, and more efficient use of resources. Moreover, the disproportionate use of hazard information has overshadowed the important role of exposure science in determinations of human safety. In addition, major risk assessments lack the clarity and transparency that hinder an understanding of the analysis and communication of key safety messages. To help answer these challenges, the HESI-managed RISK21 project was initiated to develop a scientific, transparent, and efficient approach to the evolving world of human health risk assessment. RISK21 involved over 120 participants from 12 countries, 15 government institutions, 20 universities, 2 non-governmental organizations, and 12 corporations. RISK21 developed a tiered approach that is problem formulation-based, makes maximum use of prior knowledge, and is led by exposure science to produce a highly transparent and flexible visualization of and approach to assessing human safety and risk. The general principles underlying the RISK21 approach as well as an overview of the RISK21 Roadmap are presented here. This paper will be followed by a series of publications that will articulate the details that comprise this systematic approach. The purpose of this manuscript is to provide an overview

  10. Human history and deep time in nineteenth-century British sciences: An introduction.

    PubMed

    Sera-Shriar, Efram

    2015-06-01

    The historicisation of humans was a major endeavour in nineteenth-century Britain, and one that led to wide-ranging debates involving a variety of disciplinary approaches, new and old. Within the context of science and medicine these discussions centred on the issues of human origins and evolution. Did the various races living throughout the world develop from a single location, or were their physical and social differences evidence for their separate genesis? Which disciplinary tradition offered the best method for tracing human development? Was it even possible to trace that development, or had too much time passed since the dawn of humans? Furthermore, who had the authority to speak about these matters? This special issue will examine these core questions and introduce some of the ways that researchers attempted to historicise humans within the context of nineteenth-century British sciences. Copyright © 2015 Elsevier Ltd. All rights reserved.

  11. [Constant or break? On the relations between human genetics and eugenics in the Twentieth Century].

    PubMed

    Germann, Pascal

    2015-07-01

    The history of human genetics has been a neglected topic in history of science and medicine for a long time. Only recently, have medical historians begun to pay more attention to the history of human heredity. An important research question deals with the interconnections between human genetics and eugenics. This paper addresses this question: By focusing on a Swiss case study, the investigation of the heredity of goiter, I will argue that there existed close but also ambiguous relations between heredity research and eugenics in the twentieth century. Studies on human heredity often produced evidence that challenged eugenic aims and ideas. Concurrently, however, these studies fostered visions of genetic improvement of human populations.

  12. [Half a century of human and medical cytogenetics].

    PubMed

    Vago, P

    2009-01-01

    In 1956, the number of chromosomes in humans is set at 46; in 1959, the link between a disability (mongolism) and a chromosomal anomaly (the Down syndrome) is established: human and medical cytogenetics were born. Since then, progress has been remarkable: the techniques of chromosomal and molecular cytogenetics can reach a resolution of the size of a single gene with a pangenomic scope. Practical applications are constantly expanded. The clinical impact is significant, from the genetic counselling in constitutional to the targeted therapies. Fifty years later, cytogenetics can be defined as the science which aims to detect chromosomal abnormalities, whether constitutional or acquired, using chromosomal or molecular techniques aiming to study the arrangement of genes in chromosomes, to quantify the number of gene copy and to look for the presence of gene fusion.

  13. Centuries of Human-Driven Change in Salt Marsh Ecosystems

    NASA Astrophysics Data System (ADS)

    Gedan, K. Bromberg; Silliman, B. R.; Bertness, M. D.

    2009-01-01

    Salt marshes are among the most abundant, fertile, and accessible coastal habitats on earth, and they provide more ecosystem services to coastal populations than any other environment. Since the Middle Ages, humans have manipulated salt marshes at a grand scale, altering species composition, distribution, and ecosystem function. Here, we review historic and contemporary human activities in marsh ecosystems—exploitation of plant products; conversion to farmland, salt works, and urban land; introduction of non-native species; alteration of coastal hydrology; and metal and nutrient pollution. Unexpectedly, diverse types of impacts can have a similar consequence, turning salt marsh food webs upside down, dramatically increasing top down control. Of the various impacts, invasive species, runaway consumer effects, and sea level rise represent the greatest threats to salt marsh ecosystems. We conclude that the best way to protect salt marshes and the services they provide is through the integrated approach of ecosystem-based management.

  14. Centuries of human-driven change in salt marsh ecosystems.

    PubMed

    Gedan, K Bromberg; Silliman, B R; Bertness, M D

    2009-01-01

    Salt marshes are among the most abundant, fertile, and accessible coastal habitats on earth, and they provide more ecosystem services to coastal populations than any other environment. Since the Middle Ages, humans have manipulated salt marshes at a grand scale, altering species composition, distribution, and ecosystem function. Here, we review historic and contemporary human activities in marsh ecosystems--exploitation of plant products; conversion to farmland, salt works, and urban land; introduction of non-native species; alteration of coastal hydrology; and metal and nutrient pollution. Unexpectedly, diverse types of impacts can have a similar consequence, turning salt marsh food webs upside down, dramatically increasing top down control. Of the various impacts, invasive species, runaway consumer effects, and sea level rise represent the greatest threats to salt marsh ecosystems. We conclude that the best way to protect salt marshes and the services they provide is through the integrated approach of ecosystem-based management.

  15. Concerns about human hand transplantation in the 21st century.

    PubMed

    Jones, Neil F

    2002-09-01

    The decision to perform a human hand transplant was justified perhaps on less than an ideal scientific basis-only approximately 60 rat limb transplants and 2 primate limb transplants have survived for longer than 200 days and only 8 of 19 pig limb osteomyocutaneous transplants showed no signs of rejection at 90 days. It seems unlikely that the survival of a human hand transplant will be any better than the survival of a kidney transplant, which has a half-life of approximately 7.5 to 9.5 years. Fourteen hand transplants, however, have now been performed in 11 humans with the skin component of 1 remaining viable up to 3 years after surgery. Intermittent episodes of acute rejection seem to have been relatively simple to reverse by temporarily increasing the dose of immunosuppressive agents and steroids. Chronic rejection has occurred in 1 patient, necessitating re-amputation of the transplanted hand. Active range of motion of the digits has been surprisingly better than would have been expected based on previous results of replantation, but return of sensibility has been less than optimal. The immunosuppression has been well tolerated without any major medical problems or life-threatening episodes, but some patients have developed chronic viral and fungal infections and several have developed posttransplant diabetes. Extrapolating from the previous experience of solid-organ transplants, chronic immunosuppression may predispose a hand transplant patient to an 80% chance of developing an infection, a 20% potential risk of developing posttransplant diabetes, and a 4% to 18% potential risk of developing a malignancy. Even though there is universal agreement that composite tissue allograft transplantation will become the ultimate reconstructive option, no one can predict the eventual role of hand transplantation in the future, but perhaps an international database of these hand transplant patients should be established so that independent reviewers can more objectively

  16. [Evaluation of the higher brain functions in 1st and 7th grade schoolchildren belonging to two different socioeconomic groups].

    PubMed

    Nogueira, G J; Castro, A; Naveira, L; Nogueira-Antuñano, F; Natinzon, A; Gigli, S L; Grossi, M C; Frugone, M; Leofanti, H; Marchesi, M

    The higher brain functions, together with the devices that sustain them, are essential assets belonging to human beings which are used to situate themselves in the world. They can be studied by conducting neuropsychological tests, the results of which vary according to demographic factors, such as age, sex, hand dominance, culture and level of schooling. The socioeconomic level (SEL) is another factor to be taken into account and must also be evaluated. Our objective was to evaluate and analyse the influence of SEL on the results obtained from neuropsychological tests carried out in normal school-age children. We studied 401 normal children, of both sexes, taken at random, at the beginning (1st grade, 6 years old) and at the end (7th grade, 12 years old) of elementary school and belonging to two different SEL: high and low. Schools belonging to different categories were selected: public, private, urban and suburban. A battery of tests that is commonly used in Neuropsychology was utilised to evaluate laterality, spatial orientation, integration (Bender's test and the Rey figure test), attention, memory and the areas of language, gnosis and praxis. Significant differences were found in relation to the SEL in the 1st and 7th grade tests: 20/27 (74%) and 17/27 (62%), respectively. These always meant lower results in the low SEL, except body scheme, ideomotor praxis and phonological coding, which in the 7th grade run in the opposite direction. Results were not related to the type of school (urban-suburban, public-private), sex, laterality or teachers' characteristics. Differences were more striking in the area of language, basic devices (attention, memory) and in the tests that integrate several different functions (Bender's test, Rey figure test). SEL is linked to the results obtained in neuropsychological evaluation tests. There is a direct relationship with low results in the low level. There is also a correlation between certain family characteristics associated to

  17. 7th Annual Symposium on Clinical and Pharmaceutical Solutions through Analysis.

    PubMed

    Zhang, Tianyi Tee; Wang, Li; Weng, Naidong; Dong, Kelly; Valaskovic, Gary; Lee, Mike

    2016-10-01

    7th Annual Symposium on Clinical & Pharmaceutical Solutions through Analysis, Renaissance Shanghai Pudong Hotel, Shanghai, China, 20-23 April 2016 The 7th Annual Shanghai Symposium on Innovative Approaches to Reduce Attrition and Predict Clinical Outcomes (CPSA Shanghai 2016) was held on 20-23 April 2016 in Renaissance Shanghai Pudong Hotel, Shanghai, China. The meeting was featured with highly interactive events including diversified symposia, round table discussions, workshops, poster sessions and conference awards. There were over 220 participants from more than ten countries, with 61 oral presentations and 29 posters presented. In addition, the meeting included one preconference workshop and three joint sessions held with bioanalytical experts from local communities.

  18. Modeling international cooperation in human space exploration for the twenty-first century.

    PubMed

    Sadeh, E; Lester, J P; Sadeh, W Z

    1998-10-01

    The policy process of international cooperation in space exploration. including optimistic and pessimistic scenarios for the twenty-first century, is modeled and examined in this study. In the optimistic scenario, international cooperation involves a balanced and interdependent distribution of capabilities between states, their respective national space agencies and communities of space scientists and space engineers. Cooperation is characterized by interstate participation in critical path components and joint research and development. In the pessimistic scenario, international cooperation is structured and dominated politically and economically by powerful states vis-a-vis weaker states. Cooperation is limited to coordination of separate nationally approved projects and augmentation of capabilities in noncritical path components. On the basis of these two scenarios, policy predictions and implications relevant to exploration missions in the twenty-first century, such as a human-tended lunar base and human missions to Mars, are presented and discussed.

  19. Association of grade configuration with school climate for 7th and 8th grade students.

    PubMed

    Malone, Marisa; Cornell, Dewey; Shukla, Kathan

    2017-09-01

    Educational authorities have questioned whether middle schools provide the best school climate for 7th and 8th grade students, and proposed that other grade configurations such as K-8th grade schools may provide a better learning environment. The purpose of this study was to compare 7th and 8th grade students' perceptions of 4 key features of school climate (disciplinary structure, student support, student engagement, and prevalence of teasing and bullying) in middle schools versus elementary or high schools. Multilevel multivariate modeling in a statewide sample of 39,036 7th and 8th grade students attending 418 schools revealed that students attending middle schools had a more negative perception of school climate than students in schools with other grade configurations. Seventh grade students placed in middle schools reported lower disciplinary structure and a higher prevalence of teasing and bullying in comparison to those in elementary schools. Eighth grade students in middle schools reported poorer disciplinary structure, lower student engagement, and a higher prevalence of teasing and bullying compared to those in high schools. These findings can guide school psychologists in identifying aspects of school climate that may be troublesome for 7th and 8th grade students in schools with different grade configurations. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  20. Editorial: Papers from the 7th International Conference on Dendrochronology - Cultural Diversity, Environmental Variability

    Treesearch

    Margaret S. Devall; Elaine K. Sutherland

    2008-01-01

    The 7th International Conference on Dendrochronology - Cultural Diversity, Environmental Variability was held in Beijing, China from 11 to 17 June 2006. The conference was organized and hosted by the Institute of Botany, Chinese Academy of Sciences (IB_CAS) in conjunction with the International Union of Forest Research Organizations (IUFRO) Working Group 5.01.07 (Tree-...

  1. Assessment of an Engineering Technology Outreach Program for 4th-7th Grade Girls

    ERIC Educational Resources Information Center

    Dell, Elizabeth M.; Christman, Jeanne; Garrick, Robert D.

    2011-01-01

    This paper describes a workshop led by female Engineering Technology students, with support from female faculty, to provide an introduction to Engineering Technology to 4th-7th grade girls through a series of interactive laboratory experiments. This outreach program was developed to improve attitudes towards science and engineering in middle…

  2. Activities Using The State of the World Atlas, 7th Edition

    ERIC Educational Resources Information Center

    Hegelbach, Peter; Haakenson, Dean; Starbird, Caroline

    2004-01-01

    This book is designed to accompany The State of the World Atlas, 7th Edition. The State of the World Atlas and this workbook provide a frame of reference for the changing pattern of world events. Students will become familiar with different statistical representations of the world, from birth rates to HIV/AIDS infections rates; from world…

  3. Opinions of 7th Grade Students about Enriched Educational Practices in the Scope of Science Course

    ERIC Educational Resources Information Center

    Idin, Sahin; Aydogdu, Cemil

    2016-01-01

    The purpose of this research was to determine the opinions of the students about 7th grade science courses carried out with enriched educational practices. The research was conducted throughout fall semester of 2014-2015 academic year in the scope of Systems within our Body Unit (SBU), Force and Motion Unit (FMU), and Electric within our Lives…

  4. Effects of Concept Cartoons on Mathematics Self-Efficacy of 7th Grade Students

    ERIC Educational Resources Information Center

    Sengul, Sare

    2011-01-01

    The purpose of this research is to determine the effect of concept cartoons on the students' perception of their levels of self-efficacy towards mathematics. The research has been designed as the pre-test post-test with quasi experimental control group. The research participants are composed of 94 7th grade students attending an elementary school…

  5. The Effect of Learning Integers Using Cartoons on 7th Grade Students' Attitude to Mathematics

    ERIC Educational Resources Information Center

    Sengül, Sare; Dereli, Mehtap

    2013-01-01

    The purpose of this research is to investigate the effect on students' attitudes toward mathematics when cartoons are used in teaching integers. The research was designed in the form of a pre-test and post-test with a quasi experimental control group. The research participant group was composed of sixty-one (61) 7th grade students attending an…

  6. Activities Using The State of the World Atlas, 7th Edition

    ERIC Educational Resources Information Center

    Hegelbach, Peter; Haakenson, Dean; Starbird, Caroline

    2004-01-01

    This book is designed to accompany The State of the World Atlas, 7th Edition. The State of the World Atlas and this workbook provide a frame of reference for the changing pattern of world events. Students will become familiar with different statistical representations of the world, from birth rates to HIV/AIDS infections rates; from world…

  7. Proceedings of the 7th International Symposium on the Molecular Breeding of Forage and Turf

    USDA-ARS?s Scientific Manuscript database

    The 7th International Symposium on the Molecular Breeding of Forage and Turf, MBFT2012, was held in Salt Lake City, UT, USA, from 4-7 June 2012. One-hundred and fifteen researchers from around the world presented oral and poster formats relating to ten general topics: Genetic mechanisms and applic...

  8. Recommendations from the Workshop: Environment, Ecology and Sustainable Development ICAE 7th World Assembly

    ERIC Educational Resources Information Center

    Viezzer, Moema L.

    2006-01-01

    One of the workshops presented at the 7th International Council for Adult Education (ICAE) Assembly was focused on environment, ecology, and sustainable development. The workshop had participants from Asia, Africa, Europe, South America, North America and the South Pacific. This article presents a list of recommendations from the workshop.

  9. Conceptions of Mathematics in Different Ability and Achievement Groups among 7th Grade Students

    ERIC Educational Resources Information Center

    Lepmann, Lea; Afanasjev, Juri

    2005-01-01

    This report deals with 7th grade pupils' conceptions of mathematics, its learning and teaching. The report focuses on the identification and comparison of views expressed by pupil groups of different mathematical ability and achievement. The analysis is based on the results of the ability tests, subject tests and a questionnaire conducted among…

  10. How 7th Grade Students Are Using Resources for Learning in an Online Science Course

    ERIC Educational Resources Information Center

    Schafer-Mayse, Diane L.

    2015-01-01

    In this study, 7th grade students were observed completing a series of lessons in an online science course to explore their thinking and strategies for: (1) using curriculum resources for learning, (2) developing thinking and strategies for self-assessing "assessment readiness," and (3) exploring the relationship between resource use and…

  11. Bringing Human Rights Home: Human Rights Education for the 21st Century.

    ERIC Educational Resources Information Center

    Ross, Loretta J.; Gupta, Meghna

    1998-01-01

    Discusses the purpose and focus of human-rights education. Traces the definition of human rights, emphasizing the role of the United Nations Declaration of Human Rights (UDHR). Compares the U.S. record on human rights against the UDHR. Suggests that human-rights education is limited, and offers ideas for improvement (DSK)

  12. [Review of WHO Expert Committee on Leprosy 8th report, --comparison to 7th report].

    PubMed

    Kitajima, Shinichi; En, Junichiro; Kitajima, Shiori; Barua, Sumana; Goto, Masamichi

    2014-03-01

    In 2012 the WHO Expert Committee on Leprosy published its 8th report, 14 years after the publication of its 7th report in 1998. This report, the first since the leprosy reduction goal was met in 2000, highlights key points such as improvements in the quality of various services available to patients and the efforts of individuals and societies, in addition to medical progress in diagnosis and treatment. This review will mainly describe the changes made since the 7th report. Some of the main modifications are the deletion of single lesion paucibacillary type, elongated treatment of patients with high bacterial indices, the introduction of promising new drugs, and a shift from reducing the statistical number of patients to a new target for disability prevention.

  13. 16. TWO HEAD GATES ABOUT 500 FEET NORTH OF 7TH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. TWO HEAD GATES ABOUT 500 FEET NORTH OF 7TH AVENUE (SECTION 35). - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  14. Soil science. Soil and human security in the 21st century.

    PubMed

    Amundson, Ronald; Berhe, Asmeret Asefaw; Hopmans, Jan W; Olson, Carolyn; Sztein, A Ester; Sparks, Donald L

    2015-05-08

    Human security has and will continue to rely on Earth's diverse soil resources. Yet we have now exploited the planet's most productive soils. Soil erosion greatly exceeds rates of production in many agricultural regions. Nitrogen produced by fossil fuel and geological reservoirs of other fertilizers are headed toward possible scarcity, increased cost, and/or geopolitical conflict. Climate change is accelerating the microbial release of greenhouse gases from soil organic matter and will likely play a large role in our near-term climate future. In this Review, we highlight challenges facing Earth's soil resources in the coming century. The direct and indirect response of soils to past and future human activities will play a major role in human prosperity and survival. Copyright © 2015, American Association for the Advancement of Science.

  15. The evolution of Rogers' Science of Unitary Human Beings: 21st century reflections.

    PubMed

    Wright, Barbara W

    2007-01-01

    The purpose of this article is to reflect on the state of Martha E. Rogers' science of unitary human beings as it has evolved over the past 40 years, with particular attention to the decade since her death. Although Rogers never updated her 1970 book, revised concepts and principles of homeodynamics, as reported in other publications, are discussed. In more than a decade since Rogers' death, nurse scientists have been prolific in explicating the science in scholarly research and writing. An example of theories derived from the science, as well as concepts under study, and research methods are identified. Twenty-first century thoughts on the science of unitary human beings, as expressed by three founders of the Society of Rogerian Scholars, are highlighted from an interview conducted by Fawcett. Rogers suggested that the development of a science of unitary human beings is a never ending process.

  16. Marine harmful algal blooms, human health and wellbeing: challenges and opportunities in the 21st century

    PubMed Central

    BERDALET, ELISA; FLEMING, LORA E.; GOWEN, RICHARD; DAVIDSON, KEITH; HESS, PHILIPP; BACKER, LORRAINE C.; MOORE, STEPHANIE K.; HOAGLAND, PORTER; ENEVOLDSEN, HENRIK

    2015-01-01

    Microalgal blooms are a natural part of the seasonal cycle of photosynthetic organisms in marine ecosystems. They are key components of the structure and dynamics of the oceans and thus sustain the benefits that humans obtain from these aquatic environments. However, some microalgal blooms can cause harm to humans and other organisms. These harmful algal blooms (HABs) have direct impacts on human health and negative influences on human wellbeing, mainly through their consequences to coastal ecosystem services (fisheries, tourism and recreation) and other marine organisms and environments. HABs are natural phenomena, but these events can be favoured by anthropogenic pressures in coastal areas. Global warming and associated changes in the oceans could affect HAB occurrences and toxicity as well, although forecasting the possible trends is still speculative and requires intensive multidisciplinary research. At the beginning of the 21st century, with expanding human populations, particularly in coastal and developing countries, mitigating HABs impacts on human health and wellbeing is becoming a more pressing public health need. The available tools to address this global challenge include maintaining intensive, multidisciplinary and collaborative scientific research, and strengthening the coordination with stakeholders, policymakers and the general public. Here we provide an overview of different aspects of the HABs phenomena, an important element of the intrinsic links between oceans and human health and wellbeing. PMID:26692586

  17. Marine harmful algal blooms, human health and wellbeing: challenges and opportunities in the 21st century.

    PubMed

    Berdalet, Elisa; Fleming, Lora E; Gowen, Richard; Davidson, Keith; Hess, Philipp; Backer, Lorraine C; Moore, Stephanie K; Hoagland, Porter; Enevoldsen, Henrik

    Microalgal blooms are a natural part of the seasonal cycle of photosynthetic organisms in marine ecosystems. They are key components of the structure and dynamics of the oceans and thus sustain the benefits that humans obtain from these aquatic environments. However, some microalgal blooms can cause harm to humans and other organisms. These harmful algal blooms (HABs) have direct impacts on human health and negative influences on human wellbeing, mainly through their consequences to coastal ecosystem services (fisheries, tourism and recreation) and other marine organisms and environments. HABs are natural phenomena, but these events can be favoured by anthropogenic pressures in coastal areas. Global warming and associated changes in the oceans could affect HAB occurrences and toxicity as well, although forecasting the possible trends is still speculative and requires intensive multidisciplinary research. At the beginning of the 21st century, with expanding human populations, particularly in coastal and developing countries, mitigating HABs impacts on human health and wellbeing is becoming a more pressing public health need. The available tools to address this global challenge include maintaining intensive, multidisciplinary and collaborative scientific research, and strengthening the coordination with stakeholders, policymakers and the general public. Here we provide an overview of different aspects of the HABs phenomena, an important element of the intrinsic links between oceans and human health and wellbeing.

  18. Statistically derived contributions of diverse human influences to twentieth-century temperature changes

    NASA Astrophysics Data System (ADS)

    Estrada, Francisco; Perron, Pierre; Martínez-López, Benjamín

    2013-12-01

    The warming of the climate system is unequivocal as evidenced by an increase in global temperatures by 0.8°C over the past century. However, the attribution of the observed warming to human activities remains less clear, particularly because of the apparent slow-down in warming since the late 1990s. Here we analyse radiative forcing and temperature time series with state-of-the-art statistical methods to address this question without climate model simulations. We show that long-term trends in total radiative forcing and temperatures have largely been determined by atmospheric greenhouse gas concentrations, and modulated by other radiative factors. We identify a pronounced increase in the growth rates of both temperatures and radiative forcing around 1960, which marks the onset of sustained global warming. Our analyses also reveal a contribution of human interventions to two periods when global warming slowed down. Our statistical analysis suggests that the reduction in the emissions of ozone-depleting substances under the Montreal Protocol, as well as a reduction in methane emissions, contributed to the lower rate of warming since the 1990s. Furthermore, we identify a contribution from the two world wars and the Great Depression to the documented cooling in the mid-twentieth century, through lower carbon dioxide emissions. We conclude that reductions in greenhouse gas emissions are effective in slowing the rate of warming in the short term.

  19. The human subject: an integrative animal model for 21(st) century heart failure research.

    PubMed

    Chandrasekera, P Charukeshi; Pippin, John J

    2015-01-01

    Heart failure remains a leading cause of death and it is a major cause of morbidity and mortality affecting tens of millions of people worldwide. Despite decades of extensive research conducted at enormous expense, only a handful of interventions have significantly impacted survival in heart failure. Even the most widely prescribed treatments act primarily to slow disease progression, do not provide sustained survival advantage, and have adverse side effects. Since mortality remains about 50% within five years of diagnosis, the need to increase our understanding of heart failure disease mechanisms and development of preventive and reparative therapies remains critical. Currently, the vast majority of basic science heart failure research is conducted using animal models ranging from fruit flies to primates; however, insights gleaned from decades of animal-based research efforts have not been proportional to research success in terms of deciphering human heart failure and developing effective therapeutics for human patients. Here we discuss the reasons for this translational discrepancy which can be equally attributed to the use of erroneous animal models and the lack of widespread use of human-based research methodologies and address why and how we must position our own species at center stage as the quintessential animal model for 21(st) century heart failure research. If the ultimate goal of the scientific community is to tackle the epidemic status of heart failure, the best way to achieve that goal is through prioritizing human-based, human-relevant research.

  20. The human subject: an integrative animal model for 21st century heart failure research

    PubMed Central

    Chandrasekera, P Charukeshi; Pippin, John J

    2015-01-01

    Heart failure remains a leading cause of death and it is a major cause of morbidity and mortality affecting tens of millions of people worldwide. Despite decades of extensive research conducted at enormous expense, only a handful of interventions have significantly impacted survival in heart failure. Even the most widely prescribed treatments act primarily to slow disease progression, do not provide sustained survival advantage, and have adverse side effects. Since mortality remains about 50% within five years of diagnosis, the need to increase our understanding of heart failure disease mechanisms and development of preventive and reparative therapies remains critical. Currently, the vast majority of basic science heart failure research is conducted using animal models ranging from fruit flies to primates; however, insights gleaned from decades of animal-based research efforts have not been proportional to research success in terms of deciphering human heart failure and developing effective therapeutics for human patients. Here we discuss the reasons for this translational discrepancy which can be equally attributed to the use of erroneous animal models and the lack of widespread use of human-based research methodologies and address why and how we must position our own species at center stage as the quintessential animal model for 21st century heart failure research. If the ultimate goal of the scientific community is to tackle the epidemic status of heart failure, the best way to achieve that goal is through prioritizing human-based, human-relevant research. PMID:26550463

  1. New archaeomagnetic data recovered from the study of Roman and Visigothic remains from central Spain (3rd-7th centuries)

    NASA Astrophysics Data System (ADS)

    Catanzariti, Gianluca; Gómez-Paccard, Miriam; McIntosh, Gregg; Pavón-Carrasco, Francisco J.; Chauvin, Annick; Osete, María. L.

    2012-03-01

    New archaeomagnetic results from four heated/combustion structures recovered from two archaeological sites in central Spain are reported. They have been dated by archaeological evidence and in two cases by radiocarbon dating. Rock magnetic experiments indicate low coercivity magnetic phases, such as magnetite and thermally stable maghaemite, as the main carriers of the remanent magnetization. Haematite has been observed in poorly heated baked clays. Archaeomagnetic directions have been obtained from either alternating field or thermal demagnetization experiments performed on 57 specimens coming from 46 independently oriented samples. The four well-defined archaeomagnetic directions obtained are in good agreement with previous archaeomagnetic data and with recent regional and global field models. They define the beginning of easterly declination drift that was initiated around 350-400 AD and culminated around 800-850 AD, and delineate the maximum in inclination that took place around 600-650 AD. In addition, classical Thellier-Thellier experiments including thermal remanent magnetization anisotropy and cooling rate corrections were conducted on 23 specimens. Only 13 specimens, corresponding to well-defined single component behaviour, gave reliable results. New mean archaeointensities have been obtained for two of the four studied structures (VBK1, 64.2 ± 5.0 μT and VBT1, 62.4 ± 2.6 μT). The new data suggest that two relative intensity maxima occurred in Western Europe around 320 and 630 AD, being of lower magnitude that observed in Eastern Europe.

  2. General Khalid Bin Waleed: Understanding the 7th Century Campaign against Sassanid Persian Empire from the Perspective of Operational Art

    DTIC Science & Technology

    2012-12-06

    of Military Excellence: The Evolution of Operational Theory (Portland, Oregon: Frank Cass Publishing, 1997), xiii. 19 Ludwig Van Bertalanffy ...58 Ibid, 10-11. 59 Michael Howard and Peter Paret, Carl Von Clausewitz: On War (New Jersey, Princeton University Press, 1976), 360. 60 Ibid...Limited, 1968), 4-A. 62 Carl Von Clausewitz, On War, Edited by Michael Howard, Peter Paret (New

  3. Alzheimer's disease: a report from the 7th Kuopio Alzheimer symposium.

    PubMed

    Haapasalo, Annakaisa; Pikkarainen, Maria; Soininen, Hilkka

    2015-10-01

    The 7th Kuopio Alzheimer symposium was held on 11-13 June, 2015, in Kuopio, Finland and attracted ~250 attendees from 14 different countries around the world. The theme for the symposium in its seventh year was 'From mechanisms to prevention and intervention of Alzheimer's disease'. The 3-day international scientific symposium composed of seven oral sessions and a poster session. The program, spanning from molecular mechanisms to prevention, prediction, diagnosis and treatment of Alzheimer's disease, provided a forum for the attendees to share their research, network and to obtain a comprehensive overview of the current status and future directions of research into Alzheimer's disease.

  4. 'HTA for Crisis': sharing experiences during the 7th EBHC Symposium.

    PubMed

    Wladysiuk, Magdalena; Tabor, Anna; Godman, Brian

    2013-02-01

    The Central and Eastern European Society of Technology Assessment in Health Care was founded in Krakow, Poland in 2003. On October 8th and 9th, the 7th symposium took place titled 'HTA for Crisis'. This meeting was attended by over 250 decision makers, evidence-based specialists, healthcare managers, commercial company personnel and experts. The symposium was principally divided into four main themes: insurance in times of crisis; importance of pricing of health services in times of crisis; managing welfare benefits in times of crisis and Health Technology Assessment in crisis-laden countries. The symposium finished by debating potential ways forward for healthcare systems in times of crisis.

  5. Human genetic variation and yellow fever mortality during 19th century U.S. epidemics.

    PubMed

    Blake, Lauren E; Garcia-Blanco, Mariano A

    2014-06-03

    We calculated the incidence, mortality, and case fatality rates for Caucasians and non-Caucasians during 19th century yellow fever (YF) epidemics in the United States and determined statistical significance for differences in the rates in different populations. We evaluated nongenetic host factors, including socioeconomic, environmental, cultural, demographic, and acquired immunity status that could have influenced these differences. While differences in incidence rates were not significant between Caucasians and non-Caucasians, differences in mortality and case fatality rates were statistically significant for all epidemics tested (P < 0.01). Caucasians diagnosed with YF were 6.8 times more likely to succumb than non-Caucasians with the disease. No other major causes of death during the 19th century demonstrated a similar mortality skew toward Caucasians. Nongenetic host factors were examined and could not explain these large differences. We propose that the remarkably lower case mortality rates for individuals of non-Caucasian ancestry is the result of human genetic variation in loci encoding innate immune mediators. Different degrees of severity of yellow fever have been observed across diverse populations, but this study is the first to demonstrate a statistically significant association between ancestry and the outcome of yellow fever (YF). With the global burden of mosquito-borne flaviviral infections, such as YF and dengue, on the rise, identifying and characterizing host factors could prove pivotal in the prevention of epidemics and the development of effective treatments. Copyright © 2014 Blake and Garcia-Blanco.

  6. Human Genetic Variation and Yellow Fever Mortality during 19th Century U.S. Epidemics

    PubMed Central

    2014-01-01

    ABSTRACT We calculated the incidence, mortality, and case fatality rates for Caucasians and non-Caucasians during 19th century yellow fever (YF) epidemics in the United States and determined statistical significance for differences in the rates in different populations. We evaluated nongenetic host factors, including socioeconomic, environmental, cultural, demographic, and acquired immunity status that could have influenced these differences. While differences in incidence rates were not significant between Caucasians and non-Caucasians, differences in mortality and case fatality rates were statistically significant for all epidemics tested (P < 0.01). Caucasians diagnosed with YF were 6.8 times more likely to succumb than non-Caucasians with the disease. No other major causes of death during the 19th century demonstrated a similar mortality skew toward Caucasians. Nongenetic host factors were examined and could not explain these large differences. We propose that the remarkably lower case mortality rates for individuals of non-Caucasian ancestry is the result of human genetic variation in loci encoding innate immune mediators. PMID:24895309

  7. Musical expressions of life: a look at the 18th and 19th century from a human becoming perspective.

    PubMed

    Jonas-Simpson, Christine

    2004-10-01

    What follows is an exploration of 18th and 19th century music of the Western world through a nursing science lens, specifically that of the human becoming theory. This article was written while I was enrolled in a music history course, which afforded me the opportunity to explore music as musical expressions of life. Rooted in the human becoming philosophical perspective, which focuses on unitary human experience and the quality of human life, I discuss musical expressions of life with examples from various composers throughout the 18th and 19th century. This article concludes with a reflection on musical expressions and their contribution to the enhancement of the quality of human life, a focus of nursing from a human becoming perspective.

  8. The science behind the 7th edition Tumour, Node, Metastasis staging system for lung cancer.

    PubMed

    Marshall, Henry M; Leong, Steven C; Bowman, Rayleen V; Yang, Ian A; Fong, Kwun M

    2012-02-01

    The Tumour, Node, Metastasis (TNM) system for classifying lung cancer is the cornerstone of modern lung cancer treatment and underpins comparative research; yet is continuously evolving through updated revisions. The recently published Union for International Cancer Control 7th Edition TNM Classification for lung cancer addresses many of its predecessor's shortcomings and has been subject to rigorous evidence-based methodology. It is based on a retrospective analysis of over 80 000 lung cancer patients treated between 1990 and 2000 carried out by the International Association for the Study of Lung Cancer. The dataset was truly international and included patients treated by all modalities. Extensive internal and external validation of the findings has ensured that the recommendations are robust and generalizable. For the first time, a single classification system has been shown to be applicable not only to non-small cell lung cancer, but also to be of prognostic significance in small cell lung cancer and bronchopulmonary carcinoid tumours. We review the history of the Union for International Cancer Control TNM staging system, the changes in the most recent 7th edition and the strength of the scientific basis motivating these changes. Limitations of the current staging edition are explored, post-publication independent validation studies are reviewed, and the future of TNM staging for lung cancer is discussed.

  9. Morphometric variations of the 7th cervical vertebrae of Zulu, White, and Colored South Africans.

    PubMed

    Kibii, Job M; Pan, Rualing; Tobias, Phillip V

    2010-05-01

    The 7th cervical vertebrae of 240 cadavers of South African Zulu, White, and Colored population groups were examined to determine morphometric variation. White and Colored females had statistically significant narrower cervical anteroposterior diameters than their male counterparts, whereas no statistically significant difference between sexes of the Zulu population group was observed in this variable. In addition, although Zulu and Colored females had statistically significant narrower cervical transverse diameters than their male counterparts, there was no statistically significant variation between South African white males and females in this respect. The findings indicate that sexual dimorphism is more apparent in the vertebral centrum, across the three population groups, where males had significantly larger dimensions in centrum anteroposterior diameter, height, and width than their female counterparts. The study further reveals that sexual dimorphism is more apparent when one compares aspects of the 7th cervical vertebra between sexes within the same population group. Overall, the dimensions of the various variates of the vertebra are substantially smaller in women than in men. The smaller dimensions, particularly of the centrum, may be the result of lower skeletal mass in women and render them more vulnerable to fractures resulting from compression forces.

  10. Raman spectroscopic analysis of human remains from a seventh century cist burial on Anglesey, UK.

    PubMed

    Edwards, Howell G M; Wilson, Andrew S; Nik Hassan, Nik F; Davidson, Andrew; Burnett, Andrew

    2007-02-01

    Specimens from human remains exhibiting unusual preservation excavated from a seventh century stone cist burial at Towyn y Capel in Anglesey, UK, have been analysed using Raman spectroscopy with near-infrared laser excitation at 1,064 and 785 nm. Specimens of hair and bone provided evidence for severe degradation and microbial colonisation. The deposits within the stone cist showed that some microbially mediated compounds had been formed. Analysis of crystals found at the interface between the hair and the skeletal neck vertebrae revealed a mixture of newberyite and haematite, associated with decomposition products of the hair and bone. An interesting differential degradation was noted in the specimens analysed which could be related to the air-void and the presence of plant root inclusions into the stone cist. This is the first time that Raman spectroscopy has been used in the forensic archaeological evaluation of burial remains in complex and dynamic environments.

  11. PREFACE: 7th Asian International Seminar on Atomic and Molecular Physics

    NASA Astrophysics Data System (ADS)

    Deshmukh, Pranawa C.; Chakraborty, Purushottam; Williams, Jim F.

    2007-09-01

    These proceedings arose from the 7th Asian International Seminar on Atomic and Molecular Physics (AISAMP) which was held at the Indian Institute of Technology, Madras from 4-7 December 2006. The history of the AISAMP has been reviewed by Takayanagi http://www.physics.iitm.ac.in/~aisamp7/history.html. This international seminar/conference series grew out of the Japan-China meetings which were launched in 1985, the fourth of which was held in 1992 and carried a second title: The First Asian International Seminar on Atomic and Molecular Physics (AISAMP), thus providing a formal medium for scientists in this part of the world to report periodically and exchange their scientific thoughts. The founding nations of Japan and China were joined subsequently by Korea, Taiwan, India and Australia. The aims of the symposia included bringing together leading experts and students of atomic and molecular physics, the discussion of important problems, learning and sharing modern techniques and expanding the horizons of modern atomic and molecular physics. The fields of interest ranged from atomic and molecular structure and dynamics to photon, electron and positron scattering, to quantum information processing, the effects of symmetry and many body interactions, laser cooling, cold traps, electric and magnetic fields and to atomic and molecular physics with synchrotron radiation. Particular interest was evident in new techniques and the changes of the physical properties from atomic to condensed matter. Details of the 7th AISAMP, including the topics for the special sessions and the full programme, are available online at the conference website http://www.physics.iitm.ac.in/~aisamp7/. In total, 95 presentations were made at the 7th AISAMP, these included the Invited Talks and Contributed Poster Presentations, of which 52 appear in the present Proceedings after review by expert referees, refereed to the usual standard of the Institute of Physics journal: Journal of Physics B: Atomic

  12. Aspects That Concern Assessing Lower Secondary School Students at the Physics National Contest Exemplification for the 7th Grade

    ERIC Educational Resources Information Center

    Florian, Gabriel

    2014-01-01

    In the present article, we aim at analysing the results obtained by the 7th grade students who participated in the 50th edition of the Physics National Contest, which took place in Cluj-Napoca between the 6th and the 11th of April, 2014. Why have we chosen the 7th grade? One of the reasons is represented by the good results obtained by the…

  13. Paleoparasitological results from XVIII century human remains from Rio de Janeiro, Brazil.

    PubMed

    Jaeger, Lauren Hubert; Taglioretti, Veronica; Fugassa, Martín Horacio; Dias, Ondemar; Neto, Jandira; Iñiguez, Alena Mayo

    2013-03-01

    Paleoparasitological studies of the Brazilian colonial period are scarce. A paleoparasitological analysis was performed on human remains from the archeological site Praça XV Cemetery in Rio de Janeiro, dating from the early 18th to 19th Centuries. The samples were obtained from the Institute of the Brazilian Archaeology collection, and showed evidence of washing and brushing. Sediments were extracted from sacral foramina by scraping. Sediments from skulls were used as negative paleoparasitological controls. Spontaneous sedimentation method was performed prior to microscopic analysis. The results revealed that 8 of 10 individuals were infected with intestinal helminths and/or protozoa. Eggs of the nematodes Trichuris sp. and Ascaris sp. as well as a single taeniid egg were found. Protozoa cysts suggestive of Entamoeba sp. were also observed. Trichuris sp. was the most frequent and abundant parasite, found in 70% of individuals (26 eggs). The study showed the importance of analysis of sediment from human remains preserved in museum or scientific collections, even those subjected to a curating procedure. The levels of infection revealed here should be considered underestimations. This is the first paleoparasitological study from Rio de Janeiro city for the Brazilian colonial period and the first report of human Taenia sp. in the New World.

  14. Nonlinear impacts of small-scale natural events on Nineteenth Century human decision-making

    NASA Astrophysics Data System (ADS)

    McCormack, S. M.; Schlichting, K. M.; Urbanova, T.; Allen, T. L.; Ruffing, C. M.; Hermans, C. M.

    2009-12-01

    Natural climatological events that occurred throughout the Nineteenth Century, such as floods, droughts and hurricanes had long-lived, far-reaching consequences on the human decision-making processes occurring in the northeast United States. These events impacted the hydrological cycle, both directly -though the building of various structures- and indirectly - through an increased understanding of science; and the changing relationship between humans and their environment. This paper examines these events and associated processes through: 1) identifying specific natural events throughout the time period, occurring globally, with initial conditions conducive to long-lived consequences; 2) examining the relationship between scientific enquiry, natural events and the proliferation of dams in the northeast landscape; and 3) the growth of public health concerns, awareness of bacteriology, and municipal water supply systems. Results of this research indicate that the relationship between knowledge systems, natural events and subsequent engineering or technological fixes is complex and highly dependent on initial conditions. It highlights the time period where humans became increasingly dependent on engineered solutions to environmental problems, many of which still hold fast in our contemporary landscape. It is relevant to natural, social and governance structures in place today. The principles behind the occurrence of the natural phenomena and subsequent research and design have not changed; and understanding key events or stages in the past is tantamount to making predictions for the future.

  15. Proceedings of the 7th US/German Workshop on Salt Repository Research, Design, and Operation.

    SciTech Connect

    Hansen, Francis D.; Steininger, Walter; Bollingerfehr, Willhelm

    2017-01-01

    The 7th US/German Workshop on Salt Repository Research, Design, and Operation was held in Washington, DC on September 7-9, 2016. Over fifty participants representing governmental agencies, internationally recognized salt research groups, universities, and private companies helped advance the technical basis for salt disposal of radioactive waste. Representatives from several United States federal agencies were able to attend, including the Department of Energy´s Office of Environmental Management and Office of Nuclear Energy, the Environmental Protection Agency, the Nuclear Regulatory Commission, and the Nuclear Waste Technical Review Board. A similar representation from the German ministries showcased the covenant established in a Memorandum of Understanding executed between the United States and Germany in 2011. The US/German workshops´ results and activities also contribute significantly to the Nuclear Energy Agency Salt Club repository research agenda.

  16. Proceedings from the 7th Annual International Society for Musculoskeletal Imaging in Rheumatology (ISEMIR) conference.

    PubMed

    Troum, Orrin M; Pimienta, Olga L; Schmidt, Wolfgang A; Ostergaard, Mikkel; D'Agostino, Maria Antonietta; Gaylis, Norman; Arnold, William; Ben-Artzi, Ami; Ranganath, Veena; Seraphine, Judy L; Peterfy, Charles

    2015-08-01

    The International Society for Musculoskeletal Imaging in Rheumatology (ISEMIR) was founded in 2005 with the goal of discussing matters related to imaging in rheumatology, particularly, validation, education, and use in clinical practice and research. Because the field of musculoskeletal (MSK) imaging is rapidly evolving, continuous education in the field is imperative. ISEMIR's international faculty and world-renowned experts presented the newest information as it relates to the use of magnetic resonance imaging (MRI) and ultrasound (US) at the 7th annual ISEMIR meeting which took place on April 12-14, 2014 in Santa Monica, California. Presentations from the meeting can be viewed at www.isemir.org. Copyright © 2015 Elsevier Inc. All rights reserved.

  17. [Dilemmas of the pharmacist, 7th edition of Hungarian National Formulary in practice].

    PubMed

    Pál, Szilárd

    2005-01-01

    Most important event of year 2004 of the history of Hungarian pharmacy was the release of the 7th edition of the National Formulary. The general part of the new formulary expanded, remarks on the preparations are more detailed and dispensing technologies are more elaborated. Knowledge base on pharmaceutical substances and incompatibility is inserted as novelty. Following the principles of modern pharmacy practice the new National Formulary excludes pills, though it is still accepted as an alternative dosage form. Usage of tablets, hard gelatine capsules and medication stick as a new dosage forms are introduced. The aim of my study was to prepare and examine some new compositions of the new edition of the National Formulary to help the pharmacist's work. Results confirmed the novel solutions of the new National Formulary.

  18. Mexican American 7th Graders’ Future Work and Family Plans: Associations with Cultural Experiences and Adjustment

    PubMed Central

    Cansler, Emily; Updegraff, Kimberly A.; Simpkins, Sandra D.

    2011-01-01

    We describe Mexican American 7th graders’ expectations for future work and family roles and investigate links between patterns of future expectations and adolescents’ cultural experiences and adjustment. Adolescents participated in home interviews and a series of seven nightly phone calls. Five unique patterns of adolescents’ future expectations were identified (N = 246): Career Oriented, Independent, Family Oriented, Early, and Inconsistent. Career Oriented adolescents had the highest socioeconomic status and contact with the U.S. (e.g., generation status) whereas Family Oriented adolescents had the lowest. Cultural orientations, values, and involvement also varied across groups. For example, Career Oriented adolescents reported significantly higher familism values compared to Inconsistent adolescents. Clusters also differed on adjustment: Career Oriented and Family Oriented adolescents reported higher parental warmth and less risky behavior compared to Independent and Inconsistent adolescents. Findings underscore the multi-faceted nature of adolescents’ future expectations and the diversity in cultural experiences among Mexican origin youth. PMID:23338812

  19. Report of the 7th African Rotavirus Symposium, Cape Town, South Africa, 8th November 2012.

    PubMed

    Seheri, L M; Mwenda, J M; Page, N

    2014-11-12

    The 7th African Rotavirus Symposium was held in Cape Town, South Africa, on the 8th November 2012 as a Satellite Symposium at the First International African Vaccinology Conference. Over 150 delegates participated in this symposium including scientists, clinicians, health officials, policymakers and vaccine manufacturers from across Africa. Key topics discussed included rotavirus surveillance, rotavirus vaccine introduction, post rotavirus vaccine impact analysis and intussusception data and surveillance in Africa. The symposium provided early rotavirus vaccine adopter countries in Africa (South Africa, Ghana and Botswana) an opportunity to share up-to-date information on vaccine introduction, and allowed colleagues to share experiences in establishing routine rotavirus surveillance (Tanzania, Niger and Rwanda). Overall, the symposium highlighted the high burden of rotavirus in Africa, and the need to continue to strengthen efforts in preventing rotavirus diarrhoea in Africa.

  20. Charge It! Translating Electric Vehicle Research Results to Engage 7th and 8th Grade Girls

    NASA Astrophysics Data System (ADS)

    Egbue, Ona; Long, Suzanna; Ng, Ean-Harn

    2015-10-01

    Despite attempts to generate interest in science and technology careers, US students continue to show reduced interest in science, technology, engineering and mathematics (STEM) majors at the collegiate level. If girls are not engaged in STEM learning by the middle school level, studies show that they are even less likely to choose a science- or engineering-related major. This article presents results from a workshop for 7th and 8th grade girls designed to promote knowledge building in the area of sustainability and alternative energy use in transportation and to stimulate greater interest in STEM subjects. The workshop based on research conducted at University X focused on basic concepts of electric vehicles and electric vehicles' batteries. Tests were conducted to evaluate the students' knowledge and perceptions of electric vehicles and to determine the impact of the workshop. Early exposure to meaningful engineering experiences for these young girls may boost interest and the eventual pursuit of engineering and technology education paths.

  1. Student Solutions Manual to accompany Fundamentals of Physics,7th Edition

    NASA Astrophysics Data System (ADS)

    Halliday, David; Resnick, Robert; Walker, Jearl; Christman, J. Richard

    2004-06-01

    Work more effectively and check solutions as you go along with the text! This Student Solutions Manual that accompanies Fundamentals of Physics, 7th Edition, provides readers with complete, worked-out solutions to 30% of the end-of-chapter problems. These problems are indicated in the text by an ssm icon. No other book on the market today can match the 30-year success of Halliday, Resnick and Walker's Fundamentals of Physics! In a breezy, easy-to-understand style this Seventh Edition offers a solid understanding of fundamental physics concepts, and helps readers apply this conceptual understanding to quantitative problem solving. This book offers a unique combination of authoritative content and stimulating applications.

  2. An Epistemological Approach to French Syllabi on Human Origins during the 19th and 20th Centuries

    ERIC Educational Resources Information Center

    Quessada, Marie-Pierre; Clement, Pierre

    2007-01-01

    This study focuses on how human origins were taught in the French Natural Sciences syllabuses of the 19th and 20th centuries. We evaluate the interval between the publication of scientific concepts and their emergence in syllabuses, i.e., didactic transposition delay (DTD), to determine how long it took for scientific findings pertaining to our…

  3. Trends Affecting Ohio State University Extension in the 21st Century and the Implications for Human Capital

    ERIC Educational Resources Information Center

    Cochran, Graham R.; Ferrari, Theresa M.; Chen, Claire Yueh-Ti

    2012-01-01

    Research with a diverse array of organizations in the public and private sectors has documented a common set of trends affecting organizations and their human capital in the 21st century. Similar trends have been identified as important for Extension organizations and the Cooperative Extension System. It is important to determine if such trends…

  4. Evaluation of the 7th AJCC TNM Staging System in Point of Lymph Node Classification

    PubMed Central

    Kim, Sung Hoo; Ha, Tae Kyung

    2011-01-01

    Purpose The 7th AJCC tumor node metastasis (TNM) staging system modified the classification of the lymph node metastasis widely compared to the 6th edition. To evaluate the prognostic predictability of the new TNM staging system, we analyzed the survival rate of the gastric cancer patients assessed by the 7th staging system. Materials and Methods Among 2,083 patients who underwent resection for gastric cancer at the department of surgery, Hanyang Medical Center from July 1992 to December 2009, This study retrospectively reviewed 5-year survival rate (5YSR) of 624 patients (TanyN3M0: 464 patients, TanyNanyM1: 160 patients) focusing on the number of metastatic lymph node and distant metastasis. We evaluated the applicability of the new staging system. Results There were no significant differences in 5YSR between stage IIIC with more than 29 metastatic lymph nodes and stage IV (P=0.053). No significant differences were observed between stage IIIB with more than 28 metastatic lymph nodes and stage IV (P=0.093). Distinct survival differences were present between patients who were categorized as TanyN3M0 with 7 to 32 metastatic lymph nodes and stage IV. But patients with more than 33 metastatic lymph nodes did not show any significant differences compared to stage IV (P=0.055). Among patients with TanyN3M0, statistical significances were seen between patients with 7 to 30 metastatic lymph nodes and those with more than 31 metastatic lymph nodes. Conclusions In the new staging system, modifications of N classification is mandatory to improve prognostic prediction. Further study involving a greater number of cases is required to demonstrate the most appropriate cutoffs for N classification. PMID:22076209

  5. In vitro Comparative Evaluation of Tensile Bond Strength of 6(th), 7(th) and 8(th) Generation Dentin Bonding Agents.

    PubMed

    Kamble, Suresh S; Kandasamy, Baburajan; Thillaigovindan, Ranjani; Goyal, Nitin Kumar; Talukdar, Pratim; Seal, Mukut

    2015-05-01

    Newer dentin bonding agents were developed to improve the quality of composite restoration and to reduce time consumption in its application. The aim of the present study was to evaluate tensile bond strength of 6(th), 7(th) and 8(th) generation bonding agents by in vitro method. Selected 60 permanent teeth were assigned into 20 in each group (Group I: 6(th) generation bonding agent-Adper SE plus 3M ESPE, Group II: 7(th) generation bonding agent-G-Bond GC Corp Japan and Group III: 8(th) generation dentin adhesives-FuturaBond, DC, Voco, Germany). With high-speed diamond disc, coronal dentin was exposed, and selected dentin bonding agents were applied, followed by composite restoration. All samples were saved in saline for 24 h and tensile bond strength testing was done using a universal testing machine. The obtained data were tabulated and statistically analyzed using ANOVA test. The tensile bond strength readings for 6(th) generation bonding agent was 32.2465, for 7(th) generation was 31.6734, and for 8(th)-generation dentine bonding agent was 34.74431. The highest tensile bond strength was seen in 8(th) generation bonding agent compared to 6(th) and 7(th) generation bonding agents. From the present study it can be conclude that 8(th) generation dentine adhesive (Futura DC, Voco, Germany) resulted in highest tensile bond strength compared to 6(th) (Adper SE plus, 3M ESPE) and 7(th) generation (G-Bond) dentin bonding agents.

  6. A century of human-driven changes in the carbon dioxide concentration of lakes

    NASA Astrophysics Data System (ADS)

    Perga, Marie-Elodie; Maberly, Stephen C.; Jenny, Jean-Philippe; Alric, Benjamin; Pignol, Cécile; Naffrechoux, Emmanuel

    2016-02-01

    Now that evasion of carbon dioxide (CO2) from inland waters is accounted for in global carbon models, it is crucial to quantify how these fluxes have changed in the past and forecast how they may alter in the future in response to local and global change. Here we developed a sediment proxy for the concentration of summer surface dissolved CO2 concentration and used it to reconstruct changes over the past 150 years for three large lakes that have been affected by climate warming, changes in nutrient load, and detrital terrigenous supplies. Initially CO2 neutral to the atmosphere, all three lakes subsequently fluctuated between near equilibrium and supersaturation. Although catchment inputs have supplied CO2 to the lakes, internal processes and reallocation have ultimately regulated decadal changes in lake surface CO2 concentration. Nutrient concentration has been the dominant driver of CO2 variability for a century although the reproducible, nonmonotonic relationship of CO2 to nutrient concentration suggests an interplay between metabolic and chemical processes. Yet for two of these lakes, climatic control of CO2 concentrations has been important over the last 30 years, promoting higher surface CO2 concentrations, likely by decreasing hypolimnetic carbon storage. This new approach offers the unique opportunity to scale, a posteriori, the long-term impact of human activities on lake CO2.

  7. Nephrology from the middle ages to humanism: the Italian influence in Spain (12th-16th centuries).

    PubMed

    Palmero, J R

    1994-01-01

    The influence of medieval Italian medicine first reached Catalonia via Montpellier. Physicians from Salerno are known to have worked in Aragon, and many Italian medical and surgical texts circulated in Catalonia. By the end of the 15th century it was Valencia that maintained close ties with Italy, and in the 1st third of the 16th century, at the height of Renaissance humanism, the Castilian universities became the greatest Spanish patrons of medicine. Post-Vesalian anatomists were active and many Castilian doctors were educated in Italy. In both medieval and Renaissance Spain the most commonly described renal pathology was lithiasis. The works of Joanes Jacobi (14th century) and Julian Guttierez (15th century) are outstanding, and foreshadow the monograph on lithiasis by Sanchez de Oropesa (16th century) and the work of Francisco Diaz, probably the greatest Spanish contributor to modern nephrology. He devoted 3 books of his collected professional experience to lithiasis, renal ulcers and sores, kidney inflammation and other processes including haematuria. His view of renal anatomy was totally modern, and he strongly advocated autopsy as a means of determining the cause of death. This underlines the new anatomopathological approach to investigation that was adopted in Renaissance Spain.

  8. Twenty-first Century ethics of medical research involving human subjects: achievements and challenges.

    PubMed

    Tzamaloukas, Antonios H; Konstantinov, Konstantin N; Agaba, Emmanuel I; Raj, Dominic S C; Murata, Glen H; Glew, Robert H

    2008-01-01

    The field of ethics in medical research has seen important developments in the last three decades, but it also faces great challenges in the new century. The purposes of this report are to examine the current status of ethics of medical research involving human subjects and the nature of the ethical challenges facing this research, to identify the weakness of the current system of safeguards for ethical research, and to stress the importance of the ethical character of the researcher, which is the safeguard that has the greatest potential for protecting the research subjects. Researchers appreciate the risks of human medical research that create ethical dilemmas and the need for an ethical compromise in order to proceed with the research. The main elements of the compromise, formulated primarily from experiences in the Second World War, include: (1) the dominant position of the ethical principle of autonomy; (2) the demand for a signed informed consent; (3) the likelihood of improving health with the research protocol, which must be approved by a duly appointed supervising committee; and (4) an acceptable risk/benefit ratio. The main weakness of this set of safeguards is the difficulty with obtaining a truly informed consent. The new challenges to ethical medical research stem from certain types of research, such as genetic and stem cell research, and from the increasing involvement of the industry in planning and funding the research studies. Developing medical researchers with an ethical character and knowledge about ethics in medicine may be the most effective safeguard in protecting participants of medical research experiments.

  9. The result of Venus Orbit Insertion of Akatsuki on December 7th, 2015

    NASA Astrophysics Data System (ADS)

    Sugiyama, K. I.; Nakamura, M.; Imamura, T.; Ishii, N.; Abe, T.; Kawakatsu, Y.; Hirose, C.; Satoh, T.; Suzuki, M.; Ueno, M.; Yamazaki, A.; Iwagami, N.; Watanabe, S.; Taguchi, M.; Fukuhara, T.; Takahashi, Y.; Yamada, M.; Imai, M.; Ohtsuki, S.; Uemizu, K.; Hashimoto, G. L.; Takagi, M.; Matsuda, Y.; Ogohara, K.; Sato, N.; Kasaba, Y.; Kouyama, T.; Hirata, N.; Nakamura, R.; Yamamoto, Y.; Horinouchi, T.; Yamamoto, M.; Hayashi, Y. Y.; Nakatsuka, J.; Kashimura, H.; Sakanoi, T.; Ando, H.; Murakami, S. Y.; Sato, T.; Takagi, S.; Nakajima, K.; Peralta, J.; Lee, Y. J.

    2015-12-01

    Japan launched Venus Climate Orbiter 'Akatsuki' (JAXA's mission code name: PLANET-C) to observe the dynamics of the Venus atmosphere globally and clarify the mechanism of the atmospheric circulation. The launch was on May 21st , 2010 from the Tanegashima Space Center. The cruise to Venus was smooth, however, the first Venus Orbit Insertion (VOI) trial on December 7th, 2010 tuned out to be a failure. Later Akatsuki has been orbiting the sun. Fortunately we keep the spacecraft in a healthy condition and surprisingly we have found another chance to let this spacecraft to meet Venus in 2015. Next VOI trial will be done on December 7th, 2015 and we report the result of this operation at this AGU meeting. This mission is planed to answer the question described below. The radius of the Earth and Venus are almost the same. In addition the radiation from the sun is also almost the same. The climates of these planets, however, are much different. For example, the strong zonal wind is observed on Venus with the period of 4 days, where Venus rotates westward with the period of 243 days. The wind speed is about 100 m s-1. This is called super rotation. We will investigate from data from Akatsuki what attributes to the difference of the climates between Earth and Venus. AKATSUKI was designed for remote sensing from an equatorial, elliptical orbit to tract the atmospheric motion at different altitudes using 5 cameras (3xIR, UV, Visible) and by the radio occultation technique. The first VOI has failed due to a malfunction of the propulsion system. The check valve between the helium tank and the fuel tank was blocked by an unexpected salt formation during the cruising from the Earth to Venus. As a result the main engine (orbital maneuvering engine, OME) became oxidizer-rich and fuel-poor condition, which led to an abnormal combustion in the engine with high temperature, and finally the engine was broken. We decide to use RCS thrusters for Trajectory Control Maneuvers' (TCMs) and

  10. Effects of the 5th and 7th grade enhanced versions of the keepin' it REAL substance use prevention curriculum.

    PubMed

    Elek, Elvira; Wagstaff, David A; Hecht, Michael L

    2010-01-01

    This study assessed the outcomes of adapting the culturally-grounded, middle school, substance-use prevention intervention, keepin ' it REAL (kiR), to target elementary school students and to address acculturation. At the beginning of 5th grade, 29 schools were randomly assigned to conditions obtained by crossing grade of implementation (5th, 7th, 5th + 7th, and control/comparison) by curriculum version [kiR-Plus vs. kiR-Acculturation Enhanced (AE)]. Students (n = 1984) completed 6 assessments through the end of 8th grade. The kiR curricula generally appear no more effective than the comparison schools' programming. Students receiving either version of the kiR intervention in only the 5th grade report greater increases in substance use than did control students. Receiving the kiR-AE version twice (both 5th and 7th grades) has benefits over receiving it once.

  11. From policy coherence to 21st century convergence: a whole-of-society paradigm of human and economic development.

    PubMed

    Dubé, Laurette; Addy, Nii A; Blouin, Chantal; Drager, Nick

    2014-12-01

    The 20th century saw accelerated human and economic development, with increased convergence in income, wealth, and living standards around the world. For a large part, owing to the well-entrenched Western-centric linear and siloed industrialization pattern, this positive transformation has also been associated with complex societal challenges at the nexus of agricultural, industrial, and health sectors. Efforts at cross-sectoral policy coherence have been deployed with limited success. To go beyond what has been possible thus far, the whole-of-society (WoS) paradigm for human and economic development proposes a 21st century convergence where, instead of the rest (of the world) converging with the West, sectoral and cross-sectoral efforts converge in their single and collective policy and action on a common target of human and economic development. In this paper, we first review and discuss contributions and limitations of policy coherence approaches. We then elaborate the institutional foundation of the WoS paradigm, taking as an anchor the well-established model of polycentric governance that views individuals, and state, market, and community, forming society as part of the same complex adaptive system. Actors within such systems self-organize into nested hierarchies that operate at multiple scales and move toward 21st century convergence of human and economic development. © 2014 New York Academy of Sciences.

  12. [TNM classification of breast cancer: changes and comments on the 7th edition].

    PubMed

    Sinn, H-P; Helmchen, B; Wittekind, C H

    2010-09-01

    The 7th edition of the TNM classification includes only minor changes in the main TNM categories for breast cancer. Only ductal and lobular carcinoma in situ (DCIS, LCIS), and isolated Paget's disease of the nipple are classified as pTis, but not precursor lesions such as atypical ductal or lobular hyperplasia (ADH, ALH). AJCC emphasizes that microscopic measurement is the most accurate and preferred method to determine pT in small invasive cancers and stresses the importance of strict adherence to criteria for T4 cancers. For better distinction from micrometastases in regional lymph nodes, small clusters of cells not greater than 0.2 mm, or nonconfluent or nearly confluent clusters of cells not exceeding 200 cells in a single histologic lymph node cross section are classified as isolated tumour cells (pN0(i+)). The pN classification has otherwise remained unchanged. In the setting of patients having received neoadjuvant therapy, ypT1-ypT3 is based on the total extent of viable tumour cells, irrespective of tumour regression. Stage I breast tumours have been subdivided into Stage IA and Stage IB; Stage IB includes small tumours (TI) with lymph node micrometastases (N1mi). These changes and clarifications will contribute to maintaining the clinical and prognostic relevance of TNM in breast cancer.

  13. PREFACE: Proceedings of the 7th International LISA Symposium, Barcelona, Spain, 16-20 June 2008

    NASA Astrophysics Data System (ADS)

    Lobo, Alberto; Sopuerta, Carlos F.

    2009-07-01

    In June 2006 the LISA International Science Team (LIST) accepted the bid presented by the Institut d'Estudis Espacials de Catalunya (IEEC) to host the 7th International LISA Symposium. This was during its 11th meeting at the University of Maryland, just before the 6th edition of the Symposium started in NASA's Goddard Space Flight Center. The 7th International LISA Symposium took place at the city of Barcelona, Spain, from 16-20 June 2008, in the premises of CosmoCaixa, a modern Science Museum located in the hills near Tibidabo. Almost 240 delegates registered for the event, a record breaking figure compared to previous editions of the Symposium. Many of the most renowned world experts in LISA, Gravitational Wave Science, and Astronomy, as well as Engineers, attended LISA 7 and produced state-of-the-art presentations, while everybody benefited from the opportunity to have live discussions during the week in a friendly environment. The programme included 31 invited plenary lectures in the mornings, and 8 parallel sessions in the afternoons. These were classified into 7 major areas of research: LISA Technology, LISA PathFinder, LISA PathFinder Data Analysis, LISA Data Analysis, Gravitational Wave sources, Cosmology and Fundamental Physics with LISA and Other Gravitational Wave Detectors. 138 abstracts for communications were received, of which a selection was made by the session convenors which would fit time constraints. Up to 63 posters completed the scientific programme. More details on the programme, including some of the talks, can be found at the Symposium website: http://www.ice.cat/research/LISA_Symposium. There was however a remarkable add-on: Professor Clifford Will delivered a startling presentation to the general public, who completely filled the Auditori—the main Conference Room, 320 seats—and were invited to ask questions to the speaker who had boldly guided them through the daunting world of Black Holes, Waves of Gravity, and other Warped Ideas of

  14. 2017 The 7th International Conference on Computer Engineering and Networks

    NASA Astrophysics Data System (ADS)

    This conference proceeding is a collection of the papers accepted by the CENet 2017 - the 7th International Conference on Computer Engineering and Networks held on Shanghai from 22-23 July, 2017. This proceeding contains the five parts: Part I focuses on Machine learning (21 papers); Part II Wireless communication (21 papers); Part III Information theory (21 papers), Part IV Cloud science (14 papers) and Part V Data analysis (21 papers). Each part can be used as an excellent reference by industry practitioners, university faculty, and undergraduate as well as graduate students who need to build a knowledge base of the most current advances and state-of-practice in the topics covered by this conference proceedings. This will enable them to produce, maintain, and manage systems with high levels of trustworthiness and complexity Thanks go to the authors for their hard work and dedication as well as the reviewers for ensuring the selection of only the highest quality papers; their efforts made this proceedings possible.

  15. Boston Edison and LG&E win 7th annual substation design contest

    SciTech Connect

    Beaty, W.

    1996-07-01

    Boston`s Edison`s Network Station 53 won First Place in the engineering/operations category of Electric Light & Power`s 7th annual substation design contest. Station 53 also took Second Place in the aesthetic design category. Boston Edison is no stranger to the contest, having won top honors in the aesthetic category in the very first contest in 1990. That same year, Boston took Second Place in engineering/operations design and Third Place in aesthetic design. Station 53 occupies a 12,074-square-foot site in the heart of the Boston financial district. It replaces an existing station where the land was required for Boston`s Central Artery project. Great care was taken to ensure that Station 53 would blend into the cityscape and be pleasing to the eye. The architectural treatment was designed by the Boston Anderson-Nichols & Company Inc., in cooperation with the Boston Redevelopment Authority. The latest in engineering technology was utilized to guarantee reliability, maintain the highest service quality and provide capacity for future load growth in the downtown area. Station 53 is supplied by two underground 115-kV pipe-type transmission cables. Unattended and remotely operated, Station 53 has the capability of sectionalizing the 115-kV power supply by remote control to isolate the faulted sections.

  16. Femtosecond Microbunching of Electron Beam in a 7th Harmonic Coupled IFEL

    NASA Astrophysics Data System (ADS)

    Tochitsky, S. Ya.; Williams, O. B.; Musumeci, P.; Sung, C.; Haberberger, D. J.; Cook, A. M.; Rosenzweig, J. B.; Joshi, C.

    2009-01-01

    We report the results of studying electron beam microbunching in a 7th order IFEL interaction using coherent transition radiation emitted by the bunched beam as a diagnostic. The resonant wavelength for the undulator with a period of 3.3 cm and K = 1.8 is 74.2 μm, but it was seeded by a CO2 laser with a seven times shorter wavelength of 10.6 μm. The ˜12.3 MeV electrons were efficiently bunched longitudinally inside a ten period long undulator producing the first, second, and third harmonics in a CTR spectrum. It is shown that in the case of approximately equal sizes of the electron and the seed radiation beams, the IFEL interaction results in transverse variation of bunching which significantly affects the CTR harmonic content. The measurements were compared to the predictions of IFEL simulations. These experimental results demonstrate for the first time feasibility of using very high order harmonic coupling for efficient IFEL/FEL interactions.

  17. Trends in Science and Technology Education: Reviews and Keynotes of the 7th IOSTE Symposium. (7th, De Koningshof Veldhoven, The Netherlands, August 23-31, 1994). Part 4.

    ERIC Educational Resources Information Center

    van Trommel, Jacques, Ed.

    The overall theme of the 7th International Organization for Science and Technology Education (IOSTE) symposium was "science and technology education in a demanding society". The aim of the symposium was to examine the state of science and technology education in the context of the main theme and to reflect on desirable and feasible educational…

  18. Large carnivores, moose, and humans: A changing paradigm of predator management in the 21st century

    USGS Publications Warehouse

    Schwartz, Charles C.; Swenson, J.E.; Miller, Sterling D.

    2003-01-01

    We compare and contrast the evolution of human attitudes toward large carnivores between Europe and North America. In general, persecution of large carnivores began much earlier in Europe than North America. Likewise, conservation programs directed at restoration and recovery appeared in European history well before they did in North America. Together, the pattern suggests there has been an evolution in how humans perceive large predators. Our early ancestors were physically vulnerable to large carnivores and developed corresponding attitudes of respect, avoidance, and acceptance. As civilization evolved and man developed weapons, the balance shifted. Early civilizations, in particular those with pastoral ways, attempted to eliminate large carnivores as threats to life and property. Brown bears (Ursus arctos) and wolves (Canis lupus) were consequently extirpated from much of their range in Europe and in North America south of Canada. Efforts to protect brown bears began in the late 1880s in some European countries and population reintroductions and augmentations are ongoing. They are less controversial than in North America. On the other hand, there are no wolf introductions, as has occurred in North America, and Europeans have a more negative attitude towards wolves. Control of predators to enhance ungulate harvest varies. In Western Europe, landowners own the hunting rights to ungulates. In the formerly communistic Eastern European countries and North America, hunting rights are held in common, although this is changing in some Eastern European countries. Wolf control to increase harvests of moose (Alces alces) occurs in parts of North America and Russia; bear control for similar reasons only occurs in parts of North America. Surprisingly, bears and wolves are not controlled to increase ungulates where private landowners have the hunting rights in Europe, although wolves were originally exterminated from these areas. Both the inability of scientific research to

  19. Ongoing problems concerning 7th TNM Staging System and Proposals for 8th TNM Staging System of Gastric Cancer

    PubMed Central

    Ureyen, Orhan; Meral, Ulvi Mehmet

    2016-01-01

    Because of different prognosis of gastric cancer patients with the same T and N stages, the impossibility of N3 staging in patients with fewer than 15 removed lymph nodes, and the presence of stage migration phenomenon, the 6th edition TNM Staging System for gastric cancer was updated to the 7th edition TNM staging system in 2009. Despite some opposing views, the superiority of the 7th edition TNM staging system compared to the 6th has been demonstrated in many studies. However, there are doubts about the 7th edition that it will reduce the stage migration phenomenon. The most important problem about the 7th TNM staging system is regarding subgroups N3a and N3b. The separation of N3 stage as N3a and N3b does not contribute to the TNM staging system. In conclusion, separate usage of N3a and N3b subgroups in the TNM staging system should be considered in the creation phase of the 8th edition. PMID:28053675

  20. 78 FR 71457 - Food Additive Regulations; Incorporation by Reference of the Food Chemicals Codex, 7th Edition

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-29

    ...) Vitamin D2 Meets FCC 7 specifications. 172.380(b) Vitamin D3 Meets FCC 7 specifications. 172.665(d)(2... Sec. 172.379 by revising paragraph (b) to read as follows: Sec. 172.379 Vitamin D 2 . * * * * * (b) Vitamin D 2 meets the specifications of the Food Chemicals Codex, 7th ed. (2010), pp. 1080-1081, which...

  1. Cultivating Environmental Virtue among 7th and 8th Graders in an Expeditionary Learning Outward Bound School

    ERIC Educational Resources Information Center

    Martin, Bruce; Bright, Alan; Cafaro, Philip; Mittelstaedt, Robin; Bruyere, Brett

    2008-01-01

    This study attempted to assess the development of environmental virtue in 7th and 8th grade students in an Expeditionary Learning Outward Bound school. The purpose of this study was twofold. First, the researchers were interested in introducing a virtue ethics perspective into their teaching of environmental ethics. Second, the researchers were…

  2. How 7th Graders Are Using Asynchronous Resources in an Online Science Course: A Mixed Methods Study

    ERIC Educational Resources Information Center

    Schafer-Mayse, Diane L.

    2013-01-01

    In this study 7th grade students were observed completing a series of lessons in an online science course to explore their thinking and strategies for using curriculum resources for learning, to explore their thinking and strategies for self-assessing their readiness for lesson assessment, and to explore the relationship between resource use and…

  3. Cultivating Environmental Virtue among 7th and 8th Graders in an Expeditionary Learning Outward Bound School

    ERIC Educational Resources Information Center

    Martin, Bruce; Bright, Alan; Cafaro, Philip; Mittelstaedt, Robin; Bruyere, Brett

    2008-01-01

    This study attempted to assess the development of environmental virtue in 7th and 8th grade students in an Expeditionary Learning Outward Bound school. The purpose of this study was twofold. First, the researchers were interested in introducing a virtue ethics perspective into their teaching of environmental ethics. Second, the researchers were…

  4. Proceedings of the International Conference on Adults Learning Mathematics (ALM-7) (7th, July 6-8, 2000, Medford, Massachusetts).

    ERIC Educational Resources Information Center

    Schmitt, Mary Jane, Ed.; Safford-Ramus, Katherine, Ed.

    This volume contains the proceedings of the 7th international conference on Adults Learning Mathematics--A Research Forum held in July, 2000 in Massachusetts. It includes posters and short oral reports under these section headings: (1) Research into Practice; (2) Large- Scale Issues: Frameworks, Standards, and Assessment; (3) Theoretical…

  5. Primary School English Teachers' Perceptions of the English Language Curriculum of 6th, 7th and 8th Grades

    ERIC Educational Resources Information Center

    Ersen Yanik, Asli

    2008-01-01

    This study aims to investigate how the teachers who have different background characteristics perceive the goals and content of the English language curriculum implemented at the 6th, 7th and 8th grades of public primary schools. The study was conducted during the 2004-2005 school year with 368 English teachers selected from the seven regions of…

  6. How 7th Graders Are Using Asynchronous Resources in an Online Science Course: A Mixed Methods Study

    ERIC Educational Resources Information Center

    Schafer-Mayse, Diane L.

    2013-01-01

    In this study 7th grade students were observed completing a series of lessons in an online science course to explore their thinking and strategies for using curriculum resources for learning, to explore their thinking and strategies for self-assessing their readiness for lesson assessment, and to explore the relationship between resource use and…

  7. Impacts of a Discussion-Based Academic Language Program on Classroom Interactions in 4th through 7th Grades

    ERIC Educational Resources Information Center

    LaRusso, Maria; Jones, Stephanie M.; Kim, Ha Yeon; Kim, James; Donovan, Suzanne; Snow, Catherine

    2016-01-01

    This paper presents an exploratory analysis of treatment-control differences in the quality of classroom interactions in 4th through 7th grade urban classrooms. Word Generation (WG) is a research-based academic language program for middle school students designed to teach novel vocabulary and literacy through language arts, math, science, and…

  8. Prevalence and Comorbidity of Emotional, Behavioral and Learning Problems: A Study of 7th-Grade Students

    ERIC Educational Resources Information Center

    Lopes, Joao A.

    2007-01-01

    This study was carried out to investigate the prevalence of emotional, behavior and academic problems and their association in a 7th grade school-based sample. Behavioral data were gathered in the beginning and end of the school year and academic data were collected six times throughout the year (twice every trimester). In the whole we found that,…

  9. Publications of Proceedings for the RF 2005 7th Workshop on High Energy Density and High Power RF

    SciTech Connect

    Luhmann, Jr, N C

    2006-01-01

    The University of California, Davis hosted the High Energy Density and High Power RF 7th Workshop on High Energy Density and High Power RF in Kalamata, Greece, 13-17 June, 2005. The Proceedings cost was supported by these funds from the U.S. Department of Energy. The Proceedings was published through the American Institute of Physics.

  10. Ongoing problems concerning 7(th) TNM Staging System and Proposals for 8(th) TNM Staging System of Gastric Cancer.

    PubMed

    Ilhan, Enver; Ureyen, Orhan; Meral, Ulvi Mehmet

    2016-01-01

    Because of different prognosis of gastric cancer patients with the same T and N stages, the impossibility of N3 staging in patients with fewer than 15 removed lymph nodes, and the presence of stage migration phenomenon, the 6(th) edition TNM Staging System for gastric cancer was updated to the 7(th) edition TNM staging system in 2009. Despite some opposing views, the superiority of the 7(th) edition TNM staging system compared to the 6(th) has been demonstrated in many studies. However, there are doubts about the 7(th) edition that it will reduce the stage migration phenomenon. The most important problem about the 7(th) TNM staging system is regarding subgroups N3a and N3b. The separation of N3 stage as N3a and N3b does not contribute to the TNM staging system. In conclusion, separate usage of N3a and N3b subgroups in the TNM staging system should be considered in the creation phase of the 8(th) edition.

  11. The Aegean in the Early 7th Millennium BC: Maritime Networks and Colonization.

    PubMed

    Horejs, B; Milić, B; Ostmann, F; Thanheiser, U; Weninger, B; Galik, A

    The process of Near Eastern neolithization and its westward expansion from the core zone in the Levant and upper Mesopotamia has been broadly discussed in recent decades, and many models have been developed to describe the spread of early farming in terms of its timing, structure, geography and sociocultural impact. Until now, based on recent intensive investigations in northwestern and western Anatolia, the discussion has mainly centred on the importance of Anatolian inland routes for the westward spread of neolithization. This contribution focuses on the potential impact of east Mediterranean and Aegean maritime networks on the spread of the Neolithic lifestyle to the western edge of the Anatolian subcontinent in the earliest phases of sedentism. Employing the longue durée model and the concept of 'social memory', we will discuss the arrival of new groups via established maritime routes. The existence of maritime networks prior to the spread of farming is already indicated by the high mobility of Epipalaeolithic/Mesolithic groups exploring the Aegean and east Mediterranean seas, and reaching, for example, the Cyclades and Cyprus. Successful navigation by these early mobile groups across the open sea is attested by the distribution of Melian obsidian. The potential existence of an additional Pre-Pottery Neolithic (PPN) obsidian network that operated between Cappadocia/Cilicia and Cyprus further hints at the importance of maritime coastal trade. Since both the coastal and the high seas networks were apparently already well established in this early period, we may further assume appropriate knowledge of geographic routes, navigational technology and other aspects of successful seafaring. This Mesolithic/PPN maritime know-how package appears to have been used by later groups, in the early 7th millennium calBC, exploring the centre of the Anatolian Aegean coast, and in time establishing some of the first permanent settlements in that region. In the present paper, we

  12. PREFACE: 7th International Conference on Applications of Physics in Financial Analysis

    NASA Astrophysics Data System (ADS)

    Takayasu, M.; Watanabe, T.; Ikeda, Y.; Takayasu, H.

    2010-04-01

    This volume contains contributed papers from the 7th international conference on 'Applications of Physics in Financial Analysis (APFA)' held at Tokyo on 1-5 March 2009. The conference was organized jointly by Tokyo Institute of Technology and Hitotsubashi University with support from the Research Institute of Economy, Trade, and Industry (RIETI), Physical Society of Japan, Japanese Economic Association, Information Processing Society of Japan, Japanese Society for Artificial Intelligence, and Japan Association for Evolutionary Economics. The first APFA conference (APFA1) was held in 1999 at Dublin, followed by APFA2 at Liege in 2000, APFA3 at London in 2001, APFA4 at Warsaw in 2003, APFA5 at Torino in 2006, and APFA6 at Lisbon in 2007. The 7th APFA conference, which is the first meeting held outside Europe, was attended by 223 researchers in physics and economics from 23 countries world-wide. In keeping with past APFA conferences, we paid special attention to issues in financial markets, which turned out to be very timely. The conference was held in March 2009, in the middle of the global financial crisis that originally started in the US and spread quickly to every corner of the world. The topic of the conference is 'New Approaches to the Analysis of Large Scale Business and Economic data'. The rapid development of information and communication technology has enabled financial/non-financial firms to keep detailed records of their business activities in the form of, for example, tick-by-tick data in financial markets, point-of-sale (POS) data on individual household's purchasing activity, and interfirm network data describing relationships among firms in terms of suppliers/customers transactions and ownerships. This growth in the scope and amount of business data available to researchers has led to a far-reaching expansion in research possibilities. Researchers not only in social sciences but also in physics, mathematics, and information sciences have recently

  13. Myocardial perfusion SPECT 2015 in Germany. Results of the 7(th) survey.

    PubMed

    Lindner, Oliver; Burchert, Wolfgang; Schäfer, Wolfgang; Hacker, Marcus

    2017-02-14

    The working group Cardiovascular Nuclear Medicine of the German Society of Nuclear Medicine presents the results of the 7th survey of myocardial perfusion SPECT (MPS) of the reporting year 2015. 268 questionnaires (173 practices [PR], 67 hospitals [HO], 28 university hospitals [UH]) were evaluated. Results of the last survey from 2012 are set in squared brackets. MPS of 121 939 [105 941] patients were reported. 98 % [95 %] of all MPS were performed with Tc-99m radiopharmaceuticals and 2 % [5 %] with Tl-201. 78 % [79 %] of all patients were studied in PR, 14 % [15 %] in HO, and 8 % [6 %] in UH. A pharmacological stress test was performed in 43 % [39 %] (22 % [24 %] adenosine, 20 % [9 %] regadenoson, 1 % [6 %] dipyridamole or dobutamine). Attenuation correction was applied in 25 % [2009: 10 %] of MPS. Gated SPECT was performed in 78 % [70 %] of all rest MPS, in 80 % [73 %] of all stress and in 76 % [67 %] of all stress and rest MPS. 53 % [33 %] of all nuclear medicine departments performed MPS scoring by default, whereas 24 % [41 %] did not apply any quantification. 31 % [26 %] of all departments noticed an increase in their counted MPS and 29 % [29 %] no changes. Data from 89 departments which participated in all surveys showed an increase in MPS count of 11.1 % (PR: 12.2 %, HO: 4.8 %, UH: 18.4 %). 70 % [60 %] of the MPS were requested by ambulatory care cardiologists. The 2015 MPS survey reveals a high-grade adherence of routine MPS practice to current guidelines. The positive trend in MPS performance and number of MPS already observed in 2012 continues. Educational training remains necessary in the field of SPECT scoring.

  14. PREFACE: The 7th International Seminar on Geometry, Continua and Microstructures

    NASA Astrophysics Data System (ADS)

    Burton, David A.

    2007-04-01

    It gives me great pleasure to present the proceedings of the 7th International Seminar on Geometry, Continua and Microstructures (GCM 7). The conference took place on 25-27 September 2006 at Lancaster University and the local organisers were Robin Tucker, Tim Walton, myself and Jonathan Gratus of the Lancaster University Mathematical Physics Group. Modern field theories of mechanically and electrically responsive continua have a wealth of interesting applications in physics. Such theories provide effective macroscopic models of complex systems, such as living tissue and material with dynamical defects, that capture macroscopic consequences of microscopic phenomena. GCM is an interdisciplinary conference series, initiated by the Eringen medallist Gérard A Maugin, that brings together physicists and applied mathematicians who have interests in continuum mechanics and differential geometry and who aim to develop new and powerful methods for analysing the behaviour of complex mechanical systems. The earlier conferences in the series were held in Paris, Madrid, Mannheim, Turin, Sinaia and Belgrade. This volume addresses a variety of topics including the physics of saturated porous media, the relationship between growth in living tissue and molecular transport, the mechanics of polymer bonds, the macroscopic properties of damaged elastomers, the mechanics of carbon nanotubes, the geometry of balance systems in Continuum Thermodynamics and wave propagation in the material manifold. I would like to warmly thank the rest of the organising committee and the conference participants for making GCM 7 an enjoyable and rewarding occasion. Photographs may be found at http://www.lancs.ac.uk/depts/spc/conf/gcm7/wss/index.htm David A Burton Editor

  15. 7th International Workshop on Microbeam Probes of Cellular Radiation Response

    SciTech Connect

    Brenner, David J.

    2009-07-21

    The extended abstracts that follow present a summary of the Proceedings of the 7th International Workshop: Microbeam Probes of Cellular Radiation Response, held at Columbia University’s Kellogg Center in New York City on March 15–17, 2006. These International Workshops on Microbeam Probes of Cellular Radiation Response have been held regularly since 1993 (1–5). Since the first workshop, there has been a rapid growth (see Fig. 1) in the number of centers developing microbeams for radiobiological research, and worldwide there are currently about 30 microbeams in operation or under development. Single-cell/single-particle microbeam systems can deliver beams of different ionizing radiations with a spatial resolution of a few micrometers down to a few tenths of a micrometer. Microbeams can be used to addressquestions relating to the effects of low doses of radiation (a single radiation track traversing a cell or group of cells), to probe subcellular targets (e.g. nucleus or cytoplasm), and to address questions regarding the propagation of information about DNA damage (for example, the radiation-induced bystander effect). Much of the recent research using microbeams has been to study low-dose effects and ‘‘non-targeted’’ responses such as bystander effects, genomic instability and adaptive responses. This Workshop provided a forum to assess the current state of microbeam technology and current biological applications and to discuss future directions for development, both technological and biological. Over 100 participants reviewed the current state of microbeam research worldwide and reported on new technological developments in the fields of both physics and biology.

  16. PREFACE: 7th International Conference on Modern Practice in Stress and Vibration Analysis

    NASA Astrophysics Data System (ADS)

    Barton, J.

    2009-07-01

    The proceedings contain the papers presented at the 7th International Conference on Modern Practice in Stress and Vibration Analysis. The collection of papers represents the range of activities that are carried out to understand the functionality of engineering systems and structures through stress/strain based evaluation and dynamic response. The scope is broad and covers theoretical studies, modelling and experimental evaluations. Many of the papers cover integration techniques and approaches to better understanding of system performance and failure. All of the papers have been peer reviewed by at least two experts and represent the state of the art of research in this area. The conference is the seventh in the series, following on from previous conferences in Bath, Glasgow, Nottingham, Dublin, Sheffield and Liverpool. Although based in the British Isles the conference has a truly international flavour with offerings from 22 countries. The conference is organised by the Institute of Physics Applied Mechanics Group (formerly the Stress and Vibration Group). It incorporates activities associated with the British Society for Strain Measurement including the Measurements Lecture, the EMex Exhibition and the Young Stress Analyst Competition. The organising committee is grateful for the support of all of the authors, the scientific committee and keynote speakers who played a significant role in the review process, to John Edwards who was instrumental in managing the paper review and submission process, Dawn Stewart and Claire Garland of the Institute of Physics for organising the conference, social programme and registration and Biana Gale of the British Society for Strain Measurement for organising the Exhibition. The organising committee is also grateful to the sponsors of the conference for their kind support and to the co-sponsors for distributing information on the conference. Professor Janice Barton Professor of Experimental Mechanics University of Southampton

  17. PREFACE: 7th International Conference on Modern Practice in Stress and Vibration Analysis

    NASA Astrophysics Data System (ADS)

    Dulieu-Barton, J. M.

    2009-07-01

    The proceedings contain the papers presented at the 7th International Conference on Modern Practice in Stress and Vibration Analysis. The collection of papers represents the range of activities that are carried out to understand the functionality of engineering systems and structures through stress/strain based evaluation and dynamic response. The scope is broad and covers theoretical studies, modelling and experimental evaluations. Many of the papers cover integration techniques and approaches to better understanding of system performance and failure. All of the papers have been peer reviewed by at least two experts and represent the state of the art of research in this area. The conference is the seventh in the series, following on from previous conferences in Bath, Glasgow, Nottingham, Dublin, Sheffield and Liverpool. Although based in the British Isles the conference has a truly international flavour with offerings from 22 countries. The conference is organised by the Institute of Physics Applied Mechanics Group (formerly the Stress and Vibration Group). It incorporates activities associated with the British Society for Strain Measurement including the Measurements Lecture, the EMex Exhibition and the Young Stress Analyst Competition. The organising committee is grateful for the support of all of the authors, the scientific committee and keynote speakers who played a significant role in the review process, to John Edwards who was instrumental in managing the paper review and submission process, Dawn Stewart and Claire Garland of the Institute of Physics for organising the conference, social programme and registration and Biana Gale of the British Society for Strain Measurement for organising the Exhibition. The organising committee is also grateful to the sponsors of the conference for their kind support and to the co-sponsors for distributing information on the conference. Professor Janice M Dulieu-Barton Professor of Experimental Mechanics University of

  18. PREFACE: 7th International Conference on Cooling & Heating Technologies (ICCHT 2014)

    NASA Astrophysics Data System (ADS)

    2015-09-01

    The Kyoto protocol has initiated a pledge from almost all developing and developed countries to be committed to reducing CO2 emissions. Development of new renewable energy technologies are also of interest in this conference. Greenhouse gases have contributed to global warming and other man-made disasters. Cooling and Heating communities also have responsibilities towards the commitment of reducing the greenhouse gas emissions. In addition, depleting natural resources also act as a threat to the Cooling and Heating industries, causing them to develop highly efficient equipment and innovative technologies. The 1st International Conference on Cooling & Heating Technologies was held in Hanoi Vietnam (Jan. 2005). Whereas the 2nd, 3rd, 4th and 5th ICCHT conferences were held in Dalian, China (Jul. 2006), Tokyo, Japan (Jul. 2007), Jinhae, Korea (Oct. 2008) and Bandung, Indonesia (Dec. 2010) respectively. The 6th International Conference on Cooling & Heating Technologies (ICCTH2012) was held in Xi'an in China on November 9-12, 2012. It is our pleasure to welcome you to the 7th International Conference on Cooling & Heating Technologies (ICCTH2014) on 4th - 6th November 2014 at the Grand Dorsett Subang Hotel, Subang Jaya, Selangor Darul Ehsan, Malaysia The Theme of the Conference is ''Sustainability and Innovation in Heating & Cooling Technologies''. The sub-themes are:- • CO2 Reduction and Low Carbon Technologies • HVAC System and Natural Ventilation • Energy & Alternative Energy • Computational Fluid Dynamics • Low Temperature & Refrigeration Engineering In conjunction with the Conference, an Exhibition will be organized as an integral part of the Conference. Project experiences, product solutions, new applications and state-of-the art information will be highlighted.

  19. Inquiry-based science: Preparing human capital for the 21 st century and beyond

    NASA Astrophysics Data System (ADS)

    Boyd, Yolanda F.

    High school students need to graduate with 21st century skills to be college and career ready and to be competitive in a global marketplace. A positive trend exists favoring inquiry-based instructional practices that purportedly not only increase science content knowledge, but also 21 st century skill development. A suburban school district, Areal Township (pseudonym), implemented an inquiry-based science program based on this trend; however, the degree to which the program has been meeting students' needs for science content knowledge and 21st century skills development has not been explored. If we were to understand the process by which an inquiry-based science program contributes to attainment of science content and 21st century skill development, then we might be able to improve the delivery of the program and provide a model to be adopted by other schools. Therefore, the purpose of this descriptive case study was to engage with multiple stakeholders to formatively assess the successes and obstacles for helping students to achieve science content and 21st century skills through an inquiry-based curriculum. Using constructivist theory, this study aimed to address the following central research question: How does the implementation of an inquiry-based program within the Areal Township School District (ATSD) support the acquisition of science content knowledge and the development of 21st century skills? This study found that 21st century skill development is embedded in inquiry-based instructional practices. These practices engage students in meaningful learning that spirals in content and is measured using diverse assessments. Time to do inquiry-based science and adequate time for collegial collaboration were obstacles for educators in grades K-5. Other obstacles were turnkey professional development and a lack of ongoing program monitoring, as a result of imposed extrinsic factors from state and federal mandates. Lastly, it was discovered that not all parts of

  20. In vitro Comparative Evaluation of Tensile Bond Strength of 6th, 7th and 8th Generation Dentin Bonding Agents

    PubMed Central

    Kamble, Suresh S; Kandasamy, Baburajan; Thillaigovindan, Ranjani; Goyal, Nitin Kumar; Talukdar, Pratim; Seal, Mukut

    2015-01-01

    Background: Newer dentin bonding agents were developed to improve the quality of composite restoration and to reduce time consumption in its application. The aim of the present study was to evaluate tensile bond strength of 6th, 7th and 8th generation bonding agents by in vitro method. Materials and Methods: Selected 60 permanent teeth were assigned into 20 in each group (Group I: 6th generation bonding agent-Adper SE plus 3M ESPE, Group II: 7th generation bonding agent-G-Bond GC Corp Japan and Group III: 8th generation dentin adhesives-FuturaBond, DC, Voco, Germany). With high-speed diamond disc, coronal dentin was exposed, and selected dentin bonding agents were applied, followed by composite restoration. All samples were saved in saline for 24 h and tensile bond strength testing was done using a universal testing machine. The obtained data were tabulated and statistically analyzed using ANOVA test. Results: The tensile bond strength readings for 6th generation bonding agent was 32.2465, for 7th generation was 31.6734, and for 8th-generation dentine bonding agent was 34.74431. The highest tensile bond strength was seen in 8th generation bonding agent compared to 6th and 7th generation bonding agents. Conclusion: From the present study it can be conclude that 8th generation dentine adhesive (Futura DC, Voco, Germany) resulted in highest tensile bond strength compared to 6th (Adper SE plus, 3M ESPE) and 7th generation (G-Bond) dentin bonding agents. PMID:26028901

  1. Responses of molluscan communities to centuries of human impact in the northern Adriatic Sea.

    PubMed

    Gallmetzer, Ivo; Haselmair, Alexandra; Tomašových, Adam; Stachowitsch, Michael; Zuschin, Martin

    2017-01-01

    In sediment cores spanning ~500 years of history in the Gulf of Trieste, down-core changes in molluscan community structure are characterized by marked shifts in species and functional composition. Between the 16th and 19th century, a strong heavy metal contamination of the sediments, most notably by Hg, together with the effects of natural climatic oscillations (increased sedimentation and organic enrichment) drive community changes. Since the early 20th century up to 2013, the combined impacts of cultural eutrophication, frequent hypoxic events and intensifying bottom trawling replace heavy metal contamination and climatic factors as the main drivers. The pollution-tolerant and opportunistic bivalve Corbula gibba and the scavenging gastropod Nassarius pygmaeus significantly increase in abundance during the 20th century, while species more sensitive to disturbances and hypoxia such as Turritella communis and Kurtiella bidentata become rare or absent. An infaunal life habit and scavenging emerge as the dominant life strategies during the late 20th century. Down-core shifts in the proportional abundances of molluscan species and functional groups represent a sensitive proxy for past ecological changes and reveal a century-long anthropogenic impact as the main driver behind these processes in the northern Adriatic Sea, offering also a unique perspective for other shallow marine ecosystems worldwide.

  2. Responses of molluscan communities to centuries of human impact in the northern Adriatic Sea

    PubMed Central

    Haselmair, Alexandra; Tomašových, Adam; Stachowitsch, Michael; Zuschin, Martin

    2017-01-01

    In sediment cores spanning ~500 years of history in the Gulf of Trieste, down-core changes in molluscan community structure are characterized by marked shifts in species and functional composition. Between the 16th and 19th century, a strong heavy metal contamination of the sediments, most notably by Hg, together with the effects of natural climatic oscillations (increased sedimentation and organic enrichment) drive community changes. Since the early 20th century up to 2013, the combined impacts of cultural eutrophication, frequent hypoxic events and intensifying bottom trawling replace heavy metal contamination and climatic factors as the main drivers. The pollution-tolerant and opportunistic bivalve Corbula gibba and the scavenging gastropod Nassarius pygmaeus significantly increase in abundance during the 20th century, while species more sensitive to disturbances and hypoxia such as Turritella communis and Kurtiella bidentata become rare or absent. An infaunal life habit and scavenging emerge as the dominant life strategies during the late 20th century. Down-core shifts in the proportional abundances of molluscan species and functional groups represent a sensitive proxy for past ecological changes and reveal a century-long anthropogenic impact as the main driver behind these processes in the northern Adriatic Sea, offering also a unique perspective for other shallow marine ecosystems worldwide. PMID:28723935

  3. THE HUMAN BEHAVIOR RATING SCALE-BRIEF: A TOOL TO MEASURE 21ST CENTURY SKILLS OF K-12 LEARNERS.

    PubMed

    Woods-Groves, Suzanne

    2015-06-01

    Currently there is a call for brief concise measurements to appraise relevant 21st century college readiness skills in K-12 learners. This study employed K-12 teachers' ratings for over 3,000 students for an existing 91-item rating scale, the Human Behavior Rating Scale, that measured the 21st century skills of persistence, curiosity, externalizing affect, internalizing affect, and cognition. Teachers' ratings for K-12 learners were used to develop a brief, concise, and manageable 30-item tool, the Human Behavior Rating Scale-Brief. Results yielded high internal consistency coefficients and inter-item correlations. The items were not biased with regard to student sex or race, and were supported through confirmatory factor analyses. In addition, when teachers' ratings were compared with students' academic and behavioral performance data, moderate to strong relationships were revealed. This study provided an essential first step in the development of a psychometrically sound, manageable, and brief tool to appraise 21st century skills in K-12 learners.

  4. Selected papers from the 7th International Conference on Microtechnologies in Medicine and Biology (MMB 2013)

    NASA Astrophysics Data System (ADS)

    Meng, Ellis; Takayama, Shuichi

    2014-03-01

    In this special section of Journal of Micromechanics and Microengineering are a collection of the best microengineering papers presented at the 7th International Conference on Microtechnologies in Medicine and Biology (MMB 2013) which took place in the seaside town of Marina del Rey, California, USA on 10-12 April, 2013. During the 3-day conference, participants enjoyed talks from 6 invited keynote speakers and 125 flash oral/poster presentations. The MMB conference is a biennial meeting with the primary purpose of fostering interactions between biologists and medical researchers, clinicians, chemists, physicists and engineers to enhance and strengthen the potential microtechnologies that will revolutionize the fields of medicine and biological sciences. The conference possesses a unique format where all poster presenters provide a brief 60 s oral presentation highlighting their research. This format was devised to provide training and exposure for young researchers, especially PhD students and postdocs, in the field and stimulate interdisciplinary exchanges. Therefore, MMB provides an intimate intellectual venue the facilitate discussions and collaborations to advance new research tools and technologies for medicine and biological sciences. The MMB conference series was co-founded by Professor David Beebe (University of Wisconsin—Madison) and Professor André Dittmar (University of Lyon) and was the first international meeting to provide a forum focusing on emerging applications of microtechnologies to unmet needs in medicine and biology. The series was held for the first time in 2000, in Lyon, France and followed by Madison, USA (2002), Oahu Island in Hawaii, USA (2005), Okinawa, Japan (2006), Québec City, Canada (2009), Lucerne, Switzerland (2011), and Marina del Rey, USA (2013). The next conference will be held in Seoul, Korea in 2015. This collection of articles highlights recent progress in microtechnologies with medical and biological applications. We are

  5. FOREWORD: 7th Symposium on Vacuum-based Science and Technology (SVBST2013)

    NASA Astrophysics Data System (ADS)

    Gulbiński, W.

    2014-11-01

    These are the proceedings of the 7th Symposium on Vacuum based Science and Technology organized in Kołobrzeg (PL) on November 19-21, 2013 by the Institute of Technology and Education, Koszalin University of Technology and the Clausius Tower Society under auspices of the Polish Vacuum Society (PTP) and the German Vacuum Society (DVG) and in collaboration with the BalticNet PlasmaTec and the Society of Vacuum Coaters (SVC). It was accompanied by the 12-th Annual Meeting of the German Vacuum Society. The mission of the Symposium is to provide a forum for presentation and exchange of expertise and research results in the field of vacuum and plasma science. After already six successful meetings organized alternately in Poland and Germany our goal is to continue and foster cooperation within the vacuum and plasma science community. This year, the Rudolf-Jaeckel Prize, awarded by the DVG for outstanding achievements in the field of vacuum based sciences, was presented to Dr Ute Bergner, president of the VACOM Vakuum Komponenten & Messtechnik GmbH and a member of our community. The full-day course organized in the framework of the Educational Program by the Society of Vacuum Coaters (SVC) and entitled: An Introduction to Physical Vapor Deposition (PVD) Processes was held on November 18, 2013 as a satellite event of the Symposium. The instructor was Prof. Ismat Shah from Delaware University (US). The Clausius Session, already traditionally organized during the Symposium was addressed this year to young generation. We invited our young colleagues to attend a series of educational lectures reporting on achievements in graphene science, scanning probe microscopy and plasma science. Lectures were given by: Prof. Jacek Baranowski from the Institute of Electronic Materials Technology in Warsaw, Prof. Teodor Gotszalk from the Wroclaw University of Technology and Prof. Holger Kersten from the Christian Albrechts University in Kiel. The Symposium was accompanied by an industry

  6. FOREWORD: The 7th Gravitational Wave Data Analysis Workshop, 17-19 December 2002, Kyoto, Japan

    NASA Astrophysics Data System (ADS)

    Kanda, Nobuyuki; Sasaki, Misao; Tagoshi, Hideyuki

    2003-09-01

    The 7th Gravitational Wave Data Analysis Workshop (GWDAW2002) was held at the International Institute for Advanced Studies (IIAS) in Kyoto, Japan, on 17-19 December 2002. The GWDAW series is one of the important international conferences supported by the Gravitational Wave International Committee (GWIC). The workshops have been held annually, and the topics covered range from data analyses for all kinds of gravitational wave detectors to theoretical issues on gravitational wave sources. This year's workshop consisted of seven categories of sessions: the status of detectors, space-based detectors, event search, detector characterization, coincidence of detectors and detector network analysis, new methods of analysis, and sources for advanced ground-based detectors. The year 2002 was an epoch-making year for gravitational wave detection experiments. Some of the large-scale ground-based laser interferometric detectors (LIGO, GEO and TAMA) entered their initial or developed stage of observation, performing scientific runs with durations of several weeks. As a result, many of the talks presented at the workshop were based on actual data taken from these experiments, and we were able to have more realistic discussions on gravitational wave detection. Furthermore, the successful operations of these laser interferometric detectors gave the gravitational wave community a strong motive to form a worldwide detector network, as practised by existing resonant-type detectors. In fact, there were reports on the simultaneous operation of five laser interferometric detectors, and a report on a plan for coincidence operations over a month. There were also reports on future space-based detectors and their source studies from aspects of the data analysis. Thanks to well-prepared talks and vivid discussions by the participants, the workshop was extremely fruitful. These proceedings contain refined and updated papers based on the talks given at the workshop and will provide readers of

  7. [On human morphological studies in New Spain and in Mexico of nineteenth century].

    PubMed

    de Micheli, Alfredo; Izaguirre-Avila, Raúl

    2007-01-01

    The renewed anatomical studies reached a culmination in the XVI century allowing the discovery of the pulmonary blood circulation and later of the systemic blood circulation. The XVII century saw the coming of microscopic anatomy and the XVIII witness the systematization of pathological anatomy. These studies will be impelled during following century toward the clinical-anatomical comparison. Regarding to America, the anatomical studies began in New Spain, when the first textbooks of anatomy, surgery and physiology were published. The first anatomy chair was established in 1621 at the Royal and Papal University of Mexico. The teaching of anatomy was modernized, making that more practical, at the Royal School of Surgery, which began to function in 1770. In the Establishment of Medical Sciences, founded in 1833, surgery was incorporated to internal medicine. This fact permitted to unify the anatomical teaching. If on examines the lists of textbooks utilized in the different periods, it comes out that these books belonged with the contemporaneous advances of science. This consideration concerns also the receptional thesis presented to Faculty of Medicine during the XIX century.

  8. Comparison of staging between the old (6th edition) and new (7th edition) TNM classifications in advanced gastric cancer.

    PubMed

    Kikuchi, Shiro; Futawatari, Nobue; Sakuramoto, Shinichi; Katada, Natsuya; Yamashita, Keishi; Shibata, Tomotaka; Nemoto, Masayuki; Watanabe, Masahiko

    2011-06-01

    The aims of the present study were to compare staging between the old (6th edition) and new (7th edition) TNM classifications, and to evaluate the prognostic impact of extended lymph node dissection according to the new nodal staging in advanced gastric cancer. A total of 609 patients with advanced gastric cancer who had undergone curative gastric resection combined with extended lymph node dissection were enrolled in the present study. Survival curves were analyzed according to staging based on the TNM 6th and 7th editions and the Japanese Classification of Gastric Carcinoma (JCGC) 14th edition. The 5-year survival rates and the consecutive stage survival with no significant differences were: IB 88%; II 74%; IIIA 53%; IIIB 39%; and IV 18% (IIIA vs. IIIB, p=0.1307) by the TNM 6th edition; IB 94%; IIA 85%; IIB 71%; IIIA 68%; IIIB 48%; IIIC 23%; and IV 13%; (IIB vs. IIIA, p=0.7665; IIIC vs. IV, p=0.4156) by the TNM 7th and JCGC 14th editions; N0 85%; N1 70%; N2 46%; N3 18%; and M1 13%; (N3 vs. M1, p=0.8640) by the TNM 6th edition; and N0 85%; N1 80%; N2 61%; N3a 46%; N3b 18%; and M1 13%; (N0 vs. N1, p=0.2735; N2 vs. N3a, p=0.0663; N3b vs. M1, p=0.8640) by the TNM 7th and JCGC 14th editions. The new classification according to the TNM 7th and the JCGC 14th editions does not always seem to be superior to the TNM 6th edition for the prognostic stratification of stages in patients who undergo curative resection for advanced gastric cancer. An extended lymph node dissection may be effective for N0-N3a, but not for N3b and M1 stages classified according to the new TNM 7th and JCGC 14th editions.

  9. Concise review: humanized models of tumor immunology in the 21st century: convergence of cancer research and tissue engineering.

    PubMed

    Holzapfel, Boris Michael; Wagner, Ferdinand; Thibaudeau, Laure; Levesque, Jean-Pierre; Hutmacher, Dietmar Werner

    2015-06-01

    Despite positive testing in animal studies, more than 80% of novel drug candidates fail to proof their efficacy when tested in humans. This is primarily due to the use of preclinical models that are not able to recapitulate the physiological or pathological processes in humans. Hence, one of the key challenges in the field of translational medicine is to "make the model organism mouse more human." To get answers to questions that would be prognostic of outcomes in human medicine, the mouse's genome can be altered in order to create a more permissive host that allows the engraftment of human cell systems. It has been shown in the past that these strategies can improve our understanding of tumor immunology. However, the translational benefits of these platforms have still to be proven. In the 21st century, several research groups and consortia around the world take up the challenge to improve our understanding of how to humanize the animal's genetic code, its cells and, based on tissue engineering principles, its extracellular microenvironment, its tissues, or entire organs with the ultimate goal to foster the translation of new therapeutic strategies from bench to bedside. This article provides an overview of the state of the art of humanized models of tumor immunology and highlights future developments in the field such as the application of tissue engineering and regenerative medicine strategies to further enhance humanized murine model systems.

  10. Study of series-connected polymer tandem solar cells based on a highly efficient donor material of PTB7-Th

    NASA Astrophysics Data System (ADS)

    Zang, Yue; Gao, Xiumin; Xin, Qing; Lin, Jun; Zhao, Jufeng

    2017-06-01

    A highly efficient donor polymer, PTB7-Th, combined with acceptor fullerene PC71BM was introduced as the subcell in the series-connected tandem devices to achieve high-performance polymer tandem solar cells. Design of the device architecture was investigated using modeling and simulation methods to identify the optimal structure and to predict performance of the tandem cells. To address the challenge of current matching between the constituent subcells, the effect of active layer thickness, different device structure, and use of ultrathin Ag film were analyzed. It was found that the distribution of optical intensity in the tandem structure can be optimized through the optical spacer effect of interfacial layers and micro-cavity effect derived from the embedded ultrathin Ag film. Our results indicate that the efficient light utilization with appropriate subcells can allow achievement of power conversion efficiency of 12%, which can be 25% higher than that of a single cell of PTB7-Th.

  11. [The IASLC lung cancer staging project. Comparing the current 6(th) TNM edition with the proposed 7(th) edition].

    PubMed

    Carvalho, Lina; Cardoso, Edgar; Nunes, Henrique; Baptista, Victor; Gomes, Ana; Couceiro, Patrícia

    2009-01-01

    The future 7th edition of TNM classification for lung cancer will be published in 2009 and comprises the IASLC recommendations for TNM parameters. The general staging of lung cancer includes the new parameters: reclassification of tumours larger than 7 cm from T2 to T3; extra tumoral nodules will change their category to T3, T4 and M1 when in the same, ipsilateral or contralateral lobe, respectively; pleural effusion will be M1a. With these alterations, cases staged as IB - T2b N0 M0 will be IIA, cases staged IIB - T2a N1 M0 will be IIA and cases IIIB- T4 N0- -1 M0 will be IIIA. The 7(th) TNM edition recommendations were applied to 203 broncho -pulmonary carcinomas, concerning epidermoid carcinomas (83) and adenocarcinomas (120) registered in the archive of the Serviço de Anatomia Patológica of the Hospitais da Universidade de Coimbra - Portugal, previously submitted to surgical resection and lymph node excision. The following alterations will be kept as the application of the future 7(th) TNM edition: 20 cases in stage IB will move to stage IIA (17) and stage IIB (3); 18 cases will change from stage IIB to stage IIA (17) and 1 case to stage IIIA; 2 cases from stage IIIB will move to stage IV; 6 cases in stage IV will move to stage IIIA (5) and 1 case to stage IIIB. In this translational adaptation from 6th to 7th TNM staging, 51 out of the 203 analysed cases change their staging, corresponding to 25.1%.

  12. 7th Annual Symposium on Self-Monitoring of Blood Glucose (SMBG), May 8–10, 2014, Helsinki, Finland

    PubMed Central

    Mlinac, Anita; Hinzmann, Rolf

    2014-01-01

    Abstract International experts in the fields of diabetes, diabetes technology, endocrinology, mobile health, sport science, and regulatory issues gathered for the 7th Annual Symposium on Self-Monitoring of Blood Glucose (SMBG). The aim of this meeting was to facilitate new collaborations and research projects to improve the lives of people with diabetes. The 2014 meeting comprised a comprehensive scientific program, parallel interactive workshops, and two keynote lectures. PMID:25211215

  13. *Abstracts - 7th IN-CAM Research Symposium, Evaluating CAM Practices: Effectiveness, Integration, Economics & Safety - November 2012.

    PubMed

    Boon, Heather; Verhoef, Marja J

    2012-10-23

    Abstract The following are abstracts of oral and poster presentations given at the 7th IN-CAM Research Symposium - Evaluating CAM Practices: Effectiveness, Integration, Economics & Safety, and the 4th HomeoNet Research Forum, a pre-Symposium event. The IN-CAM Research Symposium was held November 2 to 4, 2012 at the Leslie Dan Faculty of Pharmacy, University of Toronto, in Toronto, Ontario, Canada. For more information, please visit: www.incamresearch.ca.

  14. International Hydrogenase Conference (7th) Held at the University of Reading on August 24th to 29th 2004.

    DTIC Science & Technology

    2004-08-19

    Seibert T30 j The Tat protein transport system required for the biogenesis of extracytoplasmic hydrogenases. 13 7th International Hydrogenase Conference...Physiology and Nutrition , Polish Academy of Sciences, Jablonna, Poland. I Institute of Animal Physiology, Slovak Academy of Sciences, Kosice, Slovakia...nuclear, but not of mitochondrial, Fe/S proteins. Narl p-depleted cells do not accumulate iron in mitochondria , distinguishing these cells from mutants

  15. PREFACE: 7th International Conference on 3D Radiation Dosimetry (IC3DDose)

    NASA Astrophysics Data System (ADS)

    Thwaites, David; Baldock, Clive

    2013-06-01

    IC3DDose 2013, the 7th International Conference on 3D Radiation Dosimetry held in Sydney, Australia from 4-8 November 2012, grew out of the DosGel series, which began as DosGel99, the 1st International Workshop on Radiation Therapy Gel Dosimetry in Lexington, Kentucky. Since 1999 subsequent DoSGel conferences were held in Brisbane, Australia (2001), Ghent, Belgium (2004), Sherbrooke, Canada (2006) and Crete, Greece (2008). In 2010 the conference was held on Hilton Head Island, South Carolina and underwent a name-change to IC3DDose. The aim of the first workshop was to bring together individuals, both researchers and users, with an interest in 3D radiation dosimetry techniques, with a mix of presentations from basic science to clinical applications, which has remained an objective for all of the meetings. One rationale of DosGel99 was stated as supporting the increasing clinical implementation of gel dosimetry, as the technique appeared, at that time, to be leaving the laboratories of gel dosimetry enthusiasts and entering clinical practice. Clearly by labelling the first workshop as the 1st, there was a vision of a continuing series, which has been fulfilled. On the other hand, the expectation of widespread clinical use of gel dosimetry has perhaps not been what was hoped for and anticipated. Nevertheless the rapidly increasing demand for advanced high-precision 3D radiotherapy technology and techniques has continued apace. The need for practical and accurate 3D dosimetry methods for development and quality assurance has only increased. By the 6th meeting, held in South Carolina in 2010, the Conference Scientific Committee recognised the wider developments in 3D systems and methods and decided to widen the scope, whilst keeping the same span from basic science to applications. This was signalled by a change of name from 'Dosgel' to 'IC3DDose', a name that has continued to this latest conference. The conference objectives were: to enhance the quality and accuracy of

  16. [Change in short-term memory in pupils of 5-7th classes in the process of class work].

    PubMed

    Rybakov, V P; Orlova, N I

    2014-01-01

    The subject of this study was the investigation of the short-term memory (STM) of visual (SVM) and auditory (SAM) modality in boys and girls of the middle school age, as in the daytime, and during the course of the school week. The obtained data show that in pupils from the 5th to the 7th class SVM and SAM playback volume in children of both genders is significantly increased, while SVM productivity in boys from 6 - 7th classes is higher than in girls of the same age. The amplitude of day changes in SVM and SAM was found to decrease significantly with the age. In all age groups the range of daily fluctuations in short-term memory of both modalities in boys appears to be higher than in girls. In all age groups a significant part of schoolchildren was revealed to possess optimal forms of temporal organization of short-term memory: morning, day and morning-day types, in that while during the school week in pupils of 5th to 7th classes of both genders the number of optimal waveforms of curves of daily dynamics of short-term memory increases, which contributes to the optimization of their mental performance.

  17. Influence of human and natural forcing on European seasonal temperatures over the past centuries (Invited)

    NASA Astrophysics Data System (ADS)

    Luterbacher, J.; Hegerl, G. C.; Gonzalez-Rouco, F. J.; Tett, S. F.; Crowley, T. J.; Xoplaki, E.

    2010-12-01

    The effect of greenhouse warming on ecosystems and society depends on the regional and seasonal details of future changes. Here we use reconstructions of seasonal European temperature (Luterbacher et al. 2004, Science; Xoplaki et al. 2005, GRL) and three simulations (ECHO-G; HadCM3 and NCAR CSM1.4) over the past 5 centuries to investigate the influence of external forcing on seasonal temperature, and whether such forcing can be detected at the regional scale. We show that forcing has caused significant interdecadal temperature variations in winter and spring. External forcing, largely due to increases in greenhouse gas concentrations, is responsible for about 3/4 of the observed winter warming since the late 17th century. Average summer temperatures show a small, but significant response to external forcing prior to 1900, but no detectable influence over the entire reconstruction. In contrast, recent instrumentally recorded summer trends are highly unusual compared to past variability. Both summer and winter temperatures show significant short-term response to volcanic eruptions that are reasonably well simulated. However, the fingerprint of winter warming competes with strong dynamic winter variability, and is less robustly detectable than the summer response. Results also suggest a possible summer temperature response to solar forcing. This demonstrates, for the first time, that external forcing has a significant impact on European climate of the past few centuries, with strong seasonal differences which need to be considered when predicting impacts.

  18. Proceedings of the Seventh International Conference on Educational Data Mining (EDM) (7th, London, United Kingdom, July 4-7, 2014)

    ERIC Educational Resources Information Center

    Stamper, John, Ed.; Pardos, Zachary, Ed.; Mavrikis, Manolis, Ed.; McLaren, Bruce M., Ed.

    2014-01-01

    The 7th International Conference on Education Data Mining held on July 4th-7th, 2014, at the Institute of Education, London, UK is the leading international forum for high-quality research that mines large data sets in order to answer educational research questions that shed light on the learning process. These data sets may come from the traces…

  19. The Humanities Are Not a Luxury: A Manifesto for the Twenty-First Century

    ERIC Educational Resources Information Center

    Smith, Martha Nell

    2011-01-01

    The humanities are at the heart of knowing about the human condition; they are not a luxury. The erosion of support for the humanities and the perennial anxiety about the state of the humanities are systemic. The author contends that until people acknowledge this fact, they will keep lurching from one point to another, unable to recognize the…

  20. The Humanities Are Not a Luxury: A Manifesto for the Twenty-First Century

    ERIC Educational Resources Information Center

    Smith, Martha Nell

    2011-01-01

    The humanities are at the heart of knowing about the human condition; they are not a luxury. The erosion of support for the humanities and the perennial anxiety about the state of the humanities are systemic. The author contends that until people acknowledge this fact, they will keep lurching from one point to another, unable to recognize the…

  1. Between Galen, Geddes, and the Gael: Arthur Brock, modernity, and medical humanism in early-twentieth-century Scotland.

    PubMed

    Cantor, David

    2005-01-01

    Arthur Brock (1879-1947) is generally remembered as the physician who treated poet Wilfred Owen for shell shock and as the translator of Galen and other ancient physicians. He was also a key figure in the early-twentieth-century humanist revival within medicine. Brock's interest in humanism, I argue, was inspired by a broader concern about modernity and by a desire to return medicine and society to the more harmonious, organic existence that he believed was characteristic of ancient Greece and could still be found among "primitive" peoples, such as the Scottish Gaels. This article explores Brock's anxieties about modernity and its relations to his interests in ancient and "primitive" peoples; to his medical thought and practice; to his interests in history, sociology, language, and translation; and to his involvement in the social and political life of Edinburgh and North Queensferry, where he moved in 1925. Crucially, it shows how all these interests and activities were influenced by Brock's mentor, Edinburgh polymath Patrick Geddes. The article concludes with a discussion of Brock's place in early-twentieth-century medical humanism.

  2. [With human and divine means: the fight against disease and death in 18th century Alicante].

    PubMed

    Perdiguero Gil, Enrique

    2002-01-01

    The nucleus of this work is the wide spectrum of means available to the inhabitants of the city of Alicante in the 18th century to fight against disease. Alongside healthcare professionals properly trained as physicians, surgeons, barbers or midwives, there were both other healers of heterogeneous types and religious resources. The study considers, in a comprehensive and articulated way, the whole repertoire of therapeutic and healthcare alternatives provided to the inhabitants of Alicante. The interpretation of the results is carried out taking into account the historiographical framework developed in recent years that considers the medical marketplace as an economic and cultural concept.

  3. Constituting the human via the animal in eighteenth-century experimental neurophysiology: Albrecht von Haller's sensibility trials.

    PubMed

    Eichberg, Stephanie

    2009-01-01

    This paper will address the use of animal models as a vital constituent of 'life science in the making' by focussing on the 'sensibility trials' conducted by the Swiss physiologist Albrecht von Haller (1708-1777). Haller was a pioneering figure in the early days of neurophysiological research, being not only influential for establishing animal experimentation as a viable method to gain knowledge about (human) neurological functions. He also tackled the question of sensibility as the most fundamental property of living bodies, which came to influence our conception of bodily feeling. In analysing some of his experiments on the nervous system, this paper addresses the following questions: what does sensibility or sensation signify in eighteenth-century physiology? How was it assessed or measured during experimentation? How were nervous functions 'read', i.e., how was the observable behaviour of an experimental animal interpreted? And finally: how did Haller address the differences between humans and animals in the context of his investigations?

  4. PREFACE: Proceedings of the 7th Liquid Matter Conference (Lund, Sweden, 27 June 1 July 2008)

    NASA Astrophysics Data System (ADS)

    Kahl, Gerhard; Sciortino, Francesco; Ullner, Magnus

    2008-12-01

    (Utrecht) and to Professor Peter Pusey (Edinburgh) for their seminal studies of colloidal matter. In addition to plenary speeches by the two recipients of the Liquid Matter Prize, the scientific program consisted of ten plenary lectures, 108 symposia talks, 23 of which were keynote lectures, and 458 poster contributions. This special issue of Journal of Physics: Condensed Matter contains 47 of the oral communications. The conference was held in the buildings of Lund University and the Student Union facing the University Square in the heart of Lund. The organizers gratefully acknowledge the substantial financial support offered by the Nobel Foundation and by the Swedish Research Council. The success of the conference owes a great debt of gratitude to the members of the Local Organizing Committee and all the people who helped them tirelessly (and very efficiently) to make the conference run smoothly and to the members of the International Program Committee, who were deeply involved in the planning of the conference. During the conference dinner our colleague Lennart Piculell gave a singing performance, which included a song dedicated to the two winners of the Liquid Matter Prize, entitled Hard-Breaking Gel, whose lyrics are printed below. Finally, the Board of the Liquids Section of the European Physical Society decided that the 8th Liquid Matter Conference will be held in Vienna (Austria) 6-10 September 2011. Hard-Breaking Gel New lyrics by Lennart Piculell to the melody of Heartbreak Hotel, created in June 2008 for the 7th Liquid Matter Conference, dedicated to Henk Lekkerkerker and Peter Pusey. Well, since my baby left me, I found a new place to be! It's downtown Lund, in a narrow street, Where hundreds of cool people meet! There I don't feel lonely, No, I don't feel lonely - So, if you feel lonely, you should try! It's all about liquid matter: Liquids flow, and soft bodies swell! Your mind is blown, and your blood will boil To a hard-breaking gel. And you won't be lonely

  5. PREFACE: XTOP 2004 -- 7th Biennial Conference on High Resolution X-Ray Diffraction and Imaging

    NASA Astrophysics Data System (ADS)

    Holý, Vaclav

    2005-05-01

    The 7th Biennial Conference on High Resolution X-Ray Diffraction and Imaging (XTOP 2004) was held in the Prague suburb of Pruhonice, Czech Republic, during 7-10 September 2004. It was organized by the Czech and Slovak Crystallographic Association in cooperation with the Institute of Physics, Academy of Sciences of the Czech Republic, Prague, Masaryk University, Brno, and Charles University, Prague. XTOP 2004 took place just after EPDIC IX (European Powder Diffraction Conference) organised in Prague by the same Association during 2-5 September 2004. The Organizing Committee was supported by an International Programme Committee including about 20 prominent scientists from several European and overseas countries, whose helpful suggestions for speakers are acknowledged. The conference was sponsored by the International Union of Crystallography and by several industrial sponsors; this sponsorship allowed us to support about 20 students and young scientists. In total, 147 official delegates and 8 accompanying persons from 16 countries of three continents attended our conference. The scientific programme of the conference was divided into 11 half-day sessions and 2 poster sessions. The participants presented 147 accepted contributions; of these 9 were 45-minute long invited talks, 34 were 20-minute oral presentations and 104 were posters. All posters were displayed for the whole meeting to ensure maximum exposure and interaction between delegates. We followed the very good experience from the previous conference, XTOP 2002, and also organized pre-conference tutorial lectures presented by experts in the field: `Imaging with hard synchrotron radiation' (J Härtwig, Grenoble), `High-resolution x-ray diffractometry: determination of strain and composition' (J Stangl, Linz), `X-ray grazing-incidence scattering from surfaces and nanostructures' (U Pietsch, Potsdam) and `Hard x-ray optics' (J Hrdý, Prague). According to the recommendation of the International Program Committee

  6. A Model for Professional Education in the 21st Century: Integrating Humanities and Engineering through Writing.

    ERIC Educational Resources Information Center

    Olds, Barbara M.; Miller, Ronald L.

    The "HumEn" (Humanities/Engineering Integration) program developed at the Colorado School of Mines integrates humanities and engineering through reading and writing. Through integrative reading and writing engineering students are led to make appropriate connections between the humanities and their technical work, connections that will…

  7. Human Services: A Bona Fide Profession in the 21st Century.

    ERIC Educational Resources Information Center

    Diambra, Joel F.

    2000-01-01

    Discusses interviews with David Maloney, Franklin Rother, and Lynn McKinney concerning the status of human services as an established profession. Summarizes that human services has come a long way in establishing itself as a unique and worthwhile career and that the job market for human service workers well trained and skilled in direct service…

  8. A perspective on space exploration technology catalysis: A rationale for initiating 21st Century expansion of human civilization into outer space

    NASA Technical Reports Server (NTRS)

    Horsham, Gary A. P.

    1988-01-01

    The rationale for human exploration of space is examined. Observations of the technocatalytic potential are presented. Transferability to the terrestrial environment of 21st Century Earth is discussed. The many threats to future survival of this planet's sensitive ecosystem are also discussed in relation to the technoecological harmony that might be achievable due to the extreme demands that are naturally imposed on the development of (civilian/human) space technology. The human attempt to inhabit the inner solar system (the Moon, Mars, etc.) is proposed as the ultimate and most appropriate technology driver for the myriad of socioeconomic, ecological, and technological needs that will accompany 21st Century Earth societies.

  9. Nutrients and the human genome: New frontiers for the next century

    SciTech Connect

    Nair, P.P. Johns Hopkins Univ. School of Hygiene Public Health, Baltimore, MD )

    1993-04-01

    Nutritional individuality in humans may be governed by genomic makeup as well as by phenotypic response to specific micronutrients. As a result of the global Human Genome Initiative, it is anticipated that by 2000, the 100,000 genes in the human genome will have been mapped. Nuclear receptors, their physiological ligands, and their target genes act in concert to influence a wide range of morphogenetic and functional elements. Consequently, genetically determined nutritional individuality could conceivably redefine nutrient requirement for diverse population groups. Incorportation of nutrition-related studies in the Human Genome Initiative may facilitate the practical application of genome data to the alleviation of human problems. 11 refs.

  10. Projections of 21st Century African Climate: Implications for African Savanna Fire Dynamics, Human Health and Food Security

    NASA Astrophysics Data System (ADS)

    Adegoke, J. O.

    2015-12-01

    Fire is a key agent of change in the African savannas, which are shaped through the complex interactions between trees, C4 grasses, rainfall, temperature, CO2 and fire. These fires and their emitted smoke can have numerous direct and indirect effects on the environment, water resources, air quality, and climate. For instance, veld fires in southern Africa cause large financial losses to agriculture, livestock production and forestry on an annual basis. This study contributes to our understanding of the implications of projected surface temperature evolution in Africa for fire risk, human health and agriculture over the coming decades. We use an ensemble of high-resolution regional climate model simulations of African climate for the 21st century. Regional dowscalings and recent global circulation model projections obtained for Africa indicate that African temperatures are likely to rise at 1.5 times the global rate of temperature increase in the tropics, and at almost twice the global rate of increase in the subtropics. Warming is projected to occur during the 21st century, with increases of 4-6 °C over the subtropics and 3-5 °C over the tropics plausible by the end of the century relative to present-day climate under the A2 (low mitigation) scenario. We explore the significance of the projected warming by documenting increases in projected high fire danger days and heat-wave days. General drying is projected across the continent, even for areas (e.g. tropical Africa) where an increase in rainfall is plausible. This is due to the drastic increases in temperature that are projected, which leads to drier soils (through enhanced evaporation) despite the rainfall increases. This will likely impact negatively on crop yield, particularly on the maize crop that is of crucial importance in terms of African food security.

  11. Long-Term Surgical Outcome of 1057 Gastric GISTs According to 7th UICC/AJCC TNM System

    PubMed Central

    Kim, Min-Chan; Yook, Jeong-Hwan; Yang, Han-Kwang; Lee, Hyuk-Joon; Sohn, Tae-Sung; Hyung, Woo-Jin; Ryu, Seung-Wan; Kurokawa, Yukinori; Kim, Young-Woo; Han, Sang-Uk; Kim, Hyung-Ho; Park, Do-Joong; Kim, Wook; Lee, Sang-Il; Cho, Haruhiko; Cho, Gyu-Seok; Kim, Jin-Jo; Kim, Ki-Han; Yoo, Moon-Won

    2015-01-01

    Abstract The aim of this study was to evaluate the treatment and prognosis of gastric gastrointestinal stromal tumors (GISTs) according to the 7th UICC/AJCC tumor-node-metastasis (TNM) system and the modified National Institutes of Health (NIH) risk classification. The study cohort consisted of 1057 patients with gastric GIST who underwent surgery between January 2000 and December 2007 from 13 institutions in Korea and 2 in Japan. Clinicopathologic characteristics, surgical outcomes, recurrence, and 5-year recurrence-free survival were evaluated. The mean age of the patients was 58.6 years. Thirty patients (2.8%) had distant metastasis preoperatively. Median tumor size was 4.0 cm. Complete resection (R0 resection) was achieved in 1018 patients (96.3%). Eighty-six patients (8.1%) had postoperative complications, and 2 patients (0.2%) died within 30 days after surgery. According to the 7th UICC/AJCC TNM system, 5-year recurrence-free survival rates were 95% to 99% in stage I, 94.1% in stage II, 74.1% in stage IIIA, 48.6% in stage IIIB, and 50.0% in stage IV patients. On survival analysis of high-risk patients according to the TNM system, the 5-year recurrence-free survival rates were 91.6% in stage II, 74.1% in stage IIIA, and 48.6% in stage IIIB patients. Independent factors of recurrence following surgery for gastric GIST were gender, tumor size, mitotic count, and radicality on multivariate analysis. The treatment outcome and prognosis of gastric GIST in Korea and Japan seem more favorable compared to those in Western countries. Compared to the modified NIH risk classification, the 7th UICC/AJCC TNM system is more reflective of the 5-year recurrence-free survival of patients with gastric GIST. PMID:26469894

  12. Beyond Earth's boundaries: Human exploration of the Solar System in the 21st Century

    NASA Technical Reports Server (NTRS)

    1991-01-01

    This is an annual report describing work accomplished in developing the knowledge base that will permit informed recommendations and decisions concerning national space policy and the goal of human expansion into the solar system. The following topics are presented: (1) pathways to human exploration; (2) human exploration case studies; (3) case study results and assessment; (4) exploration program implementation strategy; (5) approach to international cooperation; (6) recommendations; and (7) future horizons.

  13. 20th century human pressures drive reductions in deepwater oxygen leading to losses of benthic methane-based food webs

    NASA Astrophysics Data System (ADS)

    Belle, Simon; Millet, Laurent; Verneaux, Valérie; Lami, Andrea; David, Etienne; Murgia, Laurie; Parent, Claire; Musazzi, Simona; Gauthier, Emilie; Bichet, Vincent; Magny, Michel

    2016-04-01

    Freshwater lakes play a key role in the global carbon cycle as sinks (organic carbon sequestration) and sources (greenhouse gas emissions). Understanding the carbon cycle response to environmental changes is becoming a crucial challenge in the context of global warming and the preponderance of human pressures. We reconstructed the long-term (1500 years) evolution of trophic functioning of the benthic food web, based on methanotrophic ancient DNA and chironomid isotope analyses). In addition, human land use is also reconstructed in three different lakes (eastern France, Jura Mountains). Our findings confirm that the benthic food web can be highly dependent on methane-derived carbon (up to 50% of the chironomid biomass) and reveal that the activation of this process can correspond to a natural functioning or be a consequence of anthropic perturbation. The studied lakes also showed a similar temporal evolution over the last century with the disappearance of the profundal aquatic insects (Chironomidae, Diptera), considered as keystone for the whole lake food web (e.g., coupling benthic-pelagic), inducing a potential collapse in the transfer of methane to top consumers. This functional state, also called the dead zone expansion, was caused by the change in human land-use occurring at the beginning of the 20th century. The strong modification of agro-pastoral practices (e.g., fertilization practices, intensive grazing, and sewage effluent) modified the influx of nutrients (by diffuse and/or point-source inputs) and induced a significant increase in the trophic status and organic matter sedimentation to reach unprecedented values. Further studies should be planned to assess dead zone expansion and, according to the regime shift theory, to provide environmental tipping points for sustainable resource management.

  14. Proceedings of the TRADOC/Training Developments Institute, 7th Chiefs of Analysis Seminar, 22-26 March 1982.

    DTIC Science & Technology

    1982-09-01

    AO-AI19 577 ARMY TRAINING DEVELOPMENTS INST FORT MONROE VA FB 5 /9 PROCEEDINGS OF THE TRADOC/TRAINING DEVELOPMENTS INSTITUTE, 7T 7 ETC(U...NUMBER 4. TITLE (And S.brttJo) 5 TYPE OF REPORT & PERIOD COVERED Proceedings of the TRADOC/raining Developments Final Institute, 7th Chiefs of...varied subjects and 3ulicit feedback to better our analysis efforts. 5 . The agenda is attached at Incl 1. A list of attendees is at Incl 2. 6. Executive

  15. Evaluation of the 7th edition of the TNM classification in patients with resected esophageal squamous cell carcinoma.

    PubMed

    Wang, Jia; Wu, Nan; Zheng, Qing-Feng; Yan, Shi; Lv, Chao; Li, Shao-Lei; Yang, Yue

    2014-12-28

    To evaluate the prognostic factors and tumor stages of the 7(th) edition TNM classification for esophageal cancer. In total, 1033 patients with esophageal squamous cell carcinoma (ESCC) who underwent surgical resection with or without (neo)adjuvant therapy between January 2003 and June 2012 at the Thoracic Surgery Department II of the Beijing Cancer Hospital, Beijing, China were included in this study. The following eligibility criteria were applied: (1) squamous cell carcinoma of the esophagus or gastroesophageal junction identified by histopathological examination; (2) treatment with esophagectomy plus lymphadenectomy with curative intent; and (3) complete pathologic reports and follow-up data. Patients who underwent non-curative (R1) resection and patients who died in hospital were excluded. Patients who received (neo)adjuvant therapy were also included in this analysis. All patients were restaged using the 7(th) edition of the Union for International Cancer Control and the American Joint Committee on Cancer TNM staging systems. Univariate and multivariate analyses were performed to identify the prognostic factors for survival. Survival curves were plotted using the Kaplan-Meier method, and the log-rank test was used to evaluate differences between the subgroups. Of the 1033 patients, 273 patients received (neo)adjuvant therapy, and 760 patients were treated with surgery alone. The median follow-up time was 51.6 mo (range: 5-112 mo) and the overall 5-year survival rate was 36.4%. Gender, "pT" and "pN" descriptors, (neo)adjuvant therapy, and the 7(th) edition TNM stage grouping were independent prognostic factors in the univariate and multivariate analyses. However, neither histologic grade nor cancer location were independent prognostic factors in the univariate and multivariate analyses. The 5-year stage-based survival rates were as follows: IA, 84.9%; IB, 70.9%; IIA, 56.2%; IIB, 43.3%; IIIA, 37.9%; IIIB, 23.3%; IIIC,12.9% and IV, 3.4%. There were significant

  16. [Cataloging the diversity of the human body: 19th-century French nosology concerning unlawful behavior (1800-1855)].

    PubMed

    Martínez-Pérez, J

    1996-01-01

    This work aims to contribute to the study of the factors which influenced the process of the classification of the diversity of human behaviour. As a result this study will look at the changes in operation at the beginning of the nineteenth century regarding the classification of one type of deviant behaviour: homicide. The creation by French psychiatrists of the diagnostic category "monomanie homicide instintive" meant that certain types of homicide were no longer considered a crime and began to be regarded as forms of madness. The emergence and gradual disappearance of this morbid species of psychiatric classifications in the first half of the XIXth century illustrates how the assignation of aberrant behaviour to one kind or other of deviance depends on the way in which various factors are related: changes in scientific theories, permutations in the professional objectives of those who make the classifications, and the degree of social consensus which is achieved for the new meaning that the deviatory behaviour acquires on changing its position among the various forms of deviation.

  17. Animal models of human cerebellar ataxias: a cornerstone for the therapies of the twenty-first century.

    PubMed

    Manto, Mario; Marmolino, Daniele

    2009-09-01

    Cerebellar ataxias represent a group of disabling neurological disorders. Our understanding of the pathogenesis of cerebellar ataxias is continuously expanding. A considerable number of laboratory animals with neurological mutations have been reported and numerous relevant animal models mimicking the phenotype of cerebellar ataxias are becoming available. These models greatly help dissecting the numerous mechanisms of cerebellar dysfunction, a major step for the assessment of therapeutics targeting a given deleterious pathway and for the screening of old or newly synthesized chemical compounds. Nevertheless, differences between animal models and human disorders should not be overlooked and difficulties in terms of characterization should not be occulted. The identification of the mutations of many hereditary ataxias, the development of valuable animal models, and the recent identifications of the molecular mechanisms underlying cerebellar disorders represent a combination of key factors for the development of anti-ataxic innovative therapies. It is anticipated that the twenty-first century will be the century of effective therapies in the field of cerebellar ataxias. The animal models are a cornerstone to reach this goal.

  18. The history of science as the progress of the human spirit: The historiography of astronomy in the eighteenth century.

    PubMed

    Špelda, Daniel

    2017-06-01

    In the eighteenth century, the historiography of astronomy was part of a wider discussion concerning the history of the human spirit. The concept of the human spirit was very popular among Enlightenment authors because it gave the history of human knowledge continuity, unity and meaning. Using this concept, scientists and historians of science such as Montucla, Lalande, Bailly and Laplace could present the history of astronomy in terms of a progress towards contemporary science that was slow and could be interrupted at times, but was still constant, regular, and necessary. In my paper I intend to explain how the originally philosophical concept of the human spirit was transferred to the history of astronomy. I also introduce the basic principles to which the development of the spirit is subject in astronomy, according to historians of astronomy. The third part of the paper describes how historians of astronomy took into account the effect of social and natural factors on the history of astronomy. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. Theories of Human Evolution. A Century of Debate, 1844-1944.

    ERIC Educational Resources Information Center

    Bowler, Peter J.

    The question of human origin has always been disputed by evolution theorists. This book provides a comprehensive survey of the debates over human evolution from the time of Darwin to the 1940s. Part 1 discusses the early controversies, noting that they focused on philosophical issues rather than causes or details of the evolutionary process. A…

  20. Geography as Human Ecology: A Decade of Progress in a Quarter Century

    ERIC Educational Resources Information Center

    Porter, Philip W.

    1978-01-01

    Traces advances in human ecology from 1954-1978, considers research methodology used by geographers to study human ecology, and summarizes major research findings. Concludes that geographers should develop models to explain mutual relations of people and environment. (Author/DB)

  1. Theories of Human Evolution. A Century of Debate, 1844-1944.

    ERIC Educational Resources Information Center

    Bowler, Peter J.

    The question of human origin has always been disputed by evolution theorists. This book provides a comprehensive survey of the debates over human evolution from the time of Darwin to the 1940s. Part 1 discusses the early controversies, noting that they focused on philosophical issues rather than causes or details of the evolutionary process. A…

  2. Home Economics for 7th and 8th Grade Boys and Girls. Final Report.

    ERIC Educational Resources Information Center

    East Stroudsburg Area School District, PA.

    Adapted to meet local needs and goals, this curriculum guide for grades 7 and 8 is designed to help develop behaviors and skills to use in solving family-life problems. The guide consists of a course outline and separate lessons for both grades, grouped according to the major topics of human development and the family, home management and consumer…

  3. Influence of the Simulation Method on 7th Grade Students' Achievements in Science and Technology Lessons

    ERIC Educational Resources Information Center

    Teke, Huseyin; Dogan, Bekir; Duran, Ahmet

    2015-01-01

    This study aimed to make a comparative analysis of seventh-grade (the second level of the primary education) students' achievement in "Systems of The Human Body" unit in Science and Technology lesson which was taught using both the simulation method and the traditional method along with the influence of these methods on students'…

  4. Proceedings of the Annual Technology Literacy Conference. (7th, Alexandria, Virginia, February 6-9, 1992).

    ERIC Educational Resources Information Center

    Cheek, Dennis, Ed.

    The following papers are included in these proceedings: "Weaving Technology and Human Affairs" (B. Hazeltine); "Positivist and Constructivist Understandings about Science and Their Implications for STS Teaching and Learning" (B. Reeves; C. Ney); "A Modular Conceptual Framework for Technology and Work" (D. Blandow); "A Time of Uncertainty: The…

  5. Why do viruses cause cancer? Highlights of the first century of human tumour virology

    PubMed Central

    Moore, Patrick S.; Chang, Yuan

    2013-01-01

    The year 2011 marks the centenary of Francis Peyton Rous’s landmark experiments on an avian cancer virus. Since then, seven human viruses have been found to cause 10–15% of human cancers worldwide. Viruses have been central to modern cancer research and provide profound insights into both infectious and non-infectious cancer causes. This diverse group of viruses reveals unexpected connections between innate immunity, immune sensors and tumour suppressor signalling that control both viral infection and cancer. This Timeline article describes common features of human tumour viruses and discusses how new technologies can be used to identify infectious causes of cancer. PMID:21102637

  6. Multi-MW K-Band 7th Harmonic Multiplier for High-Gradient Accelerator R&D

    SciTech Connect

    Solyak, N.A.; Yakovlev, V.P.; Hirschfield, J.L.; Kazakevich, G.M.; LaPointe, M.A.; /Yale U.

    2009-05-01

    A preliminary design and current status are presented for a two-cavity 7th harmonic multiplier, intended as a high-power RF source for use in experiments aimed at developing high-gradient structures for a future collider. The harmonic multiplier is to produce power in K-band using as its RF driver an XK-5 S-band klystron (2.856 GHz). The multiplier is to be built with a TE{sub 111} rotating mode input cavity and interchangeable output cavities, a principal example being a TE{sub 711} rotating mode cavity running at 20 GHz. The design that is described uses a 250 kV, 20 A injected laminar electron beam. With 8.5 MW of S-band drive power, 4.4 MW of 20-GHz output power is predicted. The design uses a gun, magnetic coils, and beam collector from an existing waveguide 7th harmonic multiplier. The gun has been re-conditioned and the desired operating parameters have been achieved.

  7. Spontaneous human combustion in the light of the 21st century.

    PubMed

    Koljonen, Virve; Kluger, Nicolas

    2012-01-01

    The term "spontaneous human combustion" refers to a situation when a human body is found with significant portions of the middle parts of the body reduced to ashes, much less damage to the head and extremities, and minimal damage to the direct surroundings of the body. Typically, no observable source of ignition is found in the vicinity of the victim and a bad smelling oily substance is noted. In the past, such a situation was erroneously attributed to supernatural powers, as such phenomenon occurs in the absence of any witness. The purpose of this review article was to analyze articles published from January 1, 2000, on this unique type of burn injury. Further aims were to gather and present data on the causes and events leading to this situation. The literature was reviewed with PubMed interface using the key words spontaneous human combustion and preternatural combustion. Specific inclusion criteria resulted in 12 patients. A unique sequence of events takes place for the human body to incinerate to ashes. The flame burn victim has to die for the body fat to start melting. A tear in the skin has to occur for the melted fat to impregnate the charred clothes, igniting a wick effect that produces localized heat for extended period. A phenomenon called spontaneous human combustion is reality. The term "spontaneous human combustion" has nuances which are not applicable to this situation or to these modern times, therefore we suggest a new term "fat wick burns."

  8. A Century of Human-Driven Changes in the Carbon Dioxide Concentration of Lakes

    NASA Astrophysics Data System (ADS)

    Perga, M. E.; Maberly, S.; Jenny, J. P.; Alric, B.; Naffrechoux, E.

    2015-12-01

    Now that evasion of carbon dioxide (CO2) from inland waters is accounted for in global carbon models, it is crucial to quantify how these fluxes have changed in the past and forecast how they may alter in response to future local and global change. Here, we developed a sediment proxy for the concentration of summer surface dissolved CO2 concentration and used it to reconstruct changes over the past 150 years for three large lakes that have been affected by climate warming, changes in nutrient load and detrital terrigenous supplies. Initially CO2-neutral to the atmosphere, all three lakes subsequently fluctuated between near-equilibrium and supersaturation. Although catchment inputs have supplied CO2 to the lakes, internal processes have ultimately regulated decadal changes in lake surface CO2 concentration. Nutrient concentration has been the dominant driver of CO2 variability for a century although the reproducible, non-monotonic relationship of CO2 to nutrient concentration suggests the interplay between metabolic and chemical processes. Yet, for two of these lakes, climatic control of CO2 concentrations has been important over the last 30 years, promoting higher surface CO2 concentrations, likely by decreasing hypolimnetic carbon storage. This perspective challenges current knowledge on the processes and environmental drivers of variability in long-term CO2 concentrations in lakes.

  9. Human lead exposure in England from approximately 5500 BP to the 16th century AD.

    PubMed

    Budd, P; Montgomery, J; Evans, J; Trickett, M

    2004-01-05

    Lead concentration and isotope ratio data are presented for the tooth enamel of 77 individuals buried in England and spanning approximately 5000 years from the Neolithic until the 16th century AD. Whereas other tissues may be affected by diagenesis in the burial environment, the Pb concentration of tooth enamel is directly related to childhood exposure. This record is preserved post-mortem and over archaeological time. Tooth enamel Pb concentrations in the prehistoric period appear to be variable within the range 0.04 to approximately 0.4 ppm, with occasional higher levels. The Romano-British and medieval periods show a marked increase in Pb exposures with enamel concentrations reaching up to approximately 40 ppm. These exposures would today be associated with industrial pollution. Exposures appear to be highly variable compared with modern people, however, with many medieval individuals having very low enamel Pb concentrations comparable with prehistoric people. Lead isotope data refine this picture. We distinguish between the diverse isotopic ratios we believe to be characteristic of 'natural' exposure to Pb-from geological sources via the diet-and the much narrower isotopic range characteristic of exposure to technological Pb from ore sources. Taken together the data suggest that the maximum concentrations associated with 'non-technological' exposure at any period are approximately 0.5-1.0 ppm, similar to that reported for modern people in England.

  10. Whitehead Policy Symposium. The Human Genome Project: Science, law, and social change in the 21st century

    SciTech Connect

    Nichols, E.K.

    2000-02-17

    Advances in the biomedical sciences, especially in human genomics, will dramatically influence law, medicine, public health, and many other sectors of our society in the decades ahead. The public already senses the revolutionary nature of genomic knowledge. In the US and Europe, we have seen widespread discussions about genetic discrimination in health insurance; privacy issues raised by the proliferation of DNA data banks; the challenge of interpreting new DNA diagnostic tests; changing definitions of what it means to be healthy; and the science and ethics of cloning animals and human beings. The primary goal of the Whitehead/ASLME Policy Symposium was to provide a bridge between the research community and professionals, who were just beginning to grasp the potential impact of new genetic technologies on their fields. The ''Human Genome Project: Science, Law, and Social Change in the 21st Century'' initially was designed as a forum for 300-500 physicians, lawyers, consumers, ethicists, and scientists to explore the impact of new genetic technologies and prepare for the challenges ahead.

  11. Climate influence on Vibrio and associated human diseases during the past half-century in the coastal North Atlantic

    PubMed Central

    Vezzulli, Luigi; Grande, Chiara; Reid, Philip C.; Hélaouët, Pierre; Edwards, Martin; Höfle, Manfred G.; Brettar, Ingrid; Colwell, Rita R.; Pruzzo, Carla

    2016-01-01

    Climate change is having a dramatic impact on marine animal and plant communities but little is known of its influence on marine prokaryotes, which represent the largest living biomass in the world oceans and play a fundamental role in maintaining life on our planet. In this study, for the first time to our knowledge, experimental evidence is provided on the link between multidecadal climatic variability in the temperate North Atlantic and the presence and spread of an important group of marine prokaryotes, the vibrios, which are responsible for several infections in both humans and animals. Using archived formalin-preserved plankton samples collected by the Continuous Plankton Recorder survey over the past half-century (1958–2011), we assessed retrospectively the relative abundance of vibrios, including human pathogens, in nine areas of the North Atlantic and North Sea and showed correlation with climate and plankton changes. Generalized additive models revealed that long-term increase in Vibrio abundance is promoted by increasing sea surface temperatures (up to ∼1.5 °C over the past 54 y) and is positively correlated with the Northern Hemisphere Temperature (NHT) and Atlantic Multidecadal Oscillation (AMO) climatic indices (P < 0.001). Such increases are associated with an unprecedented occurrence of environmentally acquired Vibrio infections in the human population of Northern Europe and the Atlantic coast of the United States in recent years. PMID:27503882

  12. Climate influence on Vibrio and associated human diseases during the past half-century in the coastal North Atlantic.

    PubMed

    Vezzulli, Luigi; Grande, Chiara; Reid, Philip C; Hélaouët, Pierre; Edwards, Martin; Höfle, Manfred G; Brettar, Ingrid; Colwell, Rita R; Pruzzo, Carla

    2016-08-23

    Climate change is having a dramatic impact on marine animal and plant communities but little is known of its influence on marine prokaryotes, which represent the largest living biomass in the world oceans and play a fundamental role in maintaining life on our planet. In this study, for the first time to our knowledge, experimental evidence is provided on the link between multidecadal climatic variability in the temperate North Atlantic and the presence and spread of an important group of marine prokaryotes, the vibrios, which are responsible for several infections in both humans and animals. Using archived formalin-preserved plankton samples collected by the Continuous Plankton Recorder survey over the past half-century (1958-2011), we assessed retrospectively the relative abundance of vibrios, including human pathogens, in nine areas of the North Atlantic and North Sea and showed correlation with climate and plankton changes. Generalized additive models revealed that long-term increase in Vibrio abundance is promoted by increasing sea surface temperatures (up to ∼1.5 °C over the past 54 y) and is positively correlated with the Northern Hemisphere Temperature (NHT) and Atlantic Multidecadal Oscillation (AMO) climatic indices (P < 0.001). Such increases are associated with an unprecedented occurrence of environmentally acquired Vibrio infections in the human population of Northern Europe and the Atlantic coast of the United States in recent years.

  13. Beyond prejudice and pride: The human sciences in nineteenth- and twentieth-century Latin America.

    PubMed

    Rodriguez, Julia

    2013-12-01

    Grappling with problematics of status and hierarchy, recent literature on the history of the human sciences in Latin America has gone through three overlapping phases. First, the scholarship has reflected a dialogue between Latin American scientists and their European colleagues, characterized by the "center/periphery" model of scientific diffusion. Next, scholars drew on postcolonial theory to undermine the power of the "center" and to recover the role of local agents, including both elites and subalterns. In the wake of numerous studies embracing both models, the way has been cleared to look at multiple dimensions simultaneously. Histories of the human sciences in the complex multicultural societies of Latin America provide an unusually direct path to integration. Moreover, this dynamic and multilayered approach has the potential to address ambivalences about authority and power that have characterized previous analyses of the production and application of knowledge about the human condition.

  14. Update from the 7th annual meeting of the Italian Society of Virology.

    PubMed

    Salata, Cristiano; Calistri, Arianna; Palù, Giorgio

    2008-07-01

    The Italian Society of Virology (SIV) held a meeting in Orvieto (June 24-26, 2007) aimed at promoting interactions and collaborations between scientists in the field of Virology. The meeting had an attendance of about 170 virologists from Italy. In accordance with the normal format of the SIV National Meeting the conference transcended all areas of Virology. Sessions included invited speakers together with selected oral presentation. Covered topics included: General Virology and Viral Genetics, Medical Virology and Antiviral Therapy, Viral Biotechnologies and Gene Therapy, Viral Oncogenesis and Vaccines, Virus-Host Interactions and Pathogenesis, Emerging and Zoonotic Viral Infections. In this edition, a special effort was addressed to the HPV infection and prevention and to the guidelines for the preemptive (presymptomatic) therapy of human cytomegalovirus infections in transplant recipients. A summary of the main topics are reported.

  15. Occupational Outlook in the 15th Century: Sanchez de Arevalo's Mirror of Human Life.

    ERIC Educational Resources Information Center

    Chabassus, Henri; Zytowski, Donald G.

    1987-01-01

    Discusses a book published in 1468, Rodrigo Sanchez de Arevalo's "Mirror of Human Life," the earliest known comprehensive compilation of occupational descriptions. Describes the similarity of Sanchez's ideas about occupational choice and contemporary career counseling theory: informed choice; person-environment congruence; and the components of…

  16. Toward a 21st-Century Understanding of Humans' Relation to Nature: Two Hats?

    ERIC Educational Resources Information Center

    Rennie, Scott

    2008-01-01

    From its inception, environmental education (EE) has shouldered the imposition of impartiality on its methods and practices. Considering the reality of global climate change, the author urges the adoption of the more accurate theory of humans' relation to the natural world. This theory necessitates partiality toward healthy, functioning natural…

  17. Toward a 21st-Century Understanding of Humans' Relation to Nature: Two Hats?

    ERIC Educational Resources Information Center

    Rennie, Scott

    2008-01-01

    From its inception, environmental education (EE) has shouldered the imposition of impartiality on its methods and practices. Considering the reality of global climate change, the author urges the adoption of the more accurate theory of humans' relation to the natural world. This theory necessitates partiality toward healthy, functioning natural…

  18. 7th International Workshop on the Identification of Transcribed Sequences. Beyond the Identification of Transcribed Sequences

    SciTech Connect

    Gardner, Kathleen

    1997-11-19

    The Seventh Annual Human Genome Conference: Beyond the Identification of Transcribed Sequences (BITS) was held November 16-19, 1997 at the Asilomar Conference Center in Monterey, California. The format for the meeting was a combination of oral presentations, group discussions and poster sessions. The original workshop was held to discuss methodologies for the identification of transcribed sequences in mammalian genomes. Over the years, the focus of the workshops has gradually shifted towards functional analysis, with the most dramatic change in emphasis at this meeting, as reflected in the modest change in the workshop title. Topics presented and discussed included: (1) large scale expression and mutational analysis in yeast, C. elegans, Drosophila and zebrafish, (2) comparative mapping of zebrafish, chicken and Fugu; (3) functional analysis in mouse using promoter traps, mutational analysis of biochemical pathways, and Cre/lox constructs; (4) construction of 5 foot end and complete cDNA libraries; (5) expression analysis in mammalian organisms by array screening and differential display; (6) genome organization as determined by detailed transcriptional mapping and genomic sequence analysis; (7) analysis of genomic sequence, including gene and regulatory sequence predictions, annotation of genomic sequence, development of expression databases and verification of sequence analysis predictions; and (8) structural/functional relationships as determined by RNA secondary structure analysis and evolutionary conservation of non-coding sequences.

  19. Beyond the VAD: Human Factors Engineering for Mechanically Assisted Circulation in the 21st Century.

    PubMed

    Throckmorton, Amy L; Patel-Raman, Sonna M; Fox, Carson S; Bass, Ellen J

    2016-06-01

    Thousands of ventricular assist devices (VADs) currently provide circulatory support to patients worldwide, and dozens of heart pump designs for adults and pediatric patients are under various stages of development in preparation for translation to clinical use. The successful bench-to-bedside development of a VAD involves a structured evaluation of possible system states, including human interaction with the device and auxiliary component usage in the hospital or home environment. In this study, we review the literature and present the current landscape of preclinical design and assessment, decision support tools and procedures, and patient-centered therapy. Gaps of knowledge are identified. The study findings support the need for more attention to user-centered design approaches for medical devices, such as mechanical circulatory assist systems, that specifically involve detailed qualitative and quantitative assessments of human-device interaction to mitigate risk and failure.

  20. Global human appropriation of net primary production doubled in the 20th century

    PubMed Central

    Krausmann, Fridolin; Erb, Karl-Heinz; Gingrich, Simone; Haberl, Helmut; Bondeau, Alberte; Gaube, Veronika; Lauk, Christian; Plutzar, Christoph; Searchinger, Timothy D.

    2013-01-01

    Global increases in population, consumption, and gross domestic product raise concerns about the sustainability of the current and future use of natural resources. The human appropriation of net primary production (HANPP) provides a useful measure of human intervention into the biosphere. The productive capacity of land is appropriated by harvesting or burning biomass and by converting natural ecosystems to managed lands with lower productivity. This work analyzes trends in HANPP from 1910 to 2005 and finds that although human population has grown fourfold and economic output 17-fold, global HANPP has only doubled. Despite this increase in efficiency, HANPP has still risen from 6.9 Gt of carbon per y in 1910 to 14.8 GtC/y in 2005, i.e., from 13% to 25% of the net primary production of potential vegetation. Biomass harvested per capita and year has slightly declined despite growth in consumption because of a decline in reliance on bioenergy and higher conversion efficiencies of primary biomass to products. The rise in efficiency is overwhelmingly due to increased crop yields, albeit frequently associated with substantial ecological costs, such as fossil energy inputs, soil degradation, and biodiversity loss. If humans can maintain the past trend lines in efficiency gains, we estimate that HANPP might only grow to 27–29% by 2050, but providing large amounts of bioenergy could increase global HANPP to 44%. This result calls for caution in refocusing the energy economy on land-based resources and for strategies that foster the continuation of increases in land-use efficiency without excessively increasing ecological costs of intensification. PMID:23733940

  1. Brucellosis at the animal/ecosystem/human interface at the beginning of the 21st century.

    PubMed

    Godfroid, J; Scholz, H C; Barbier, T; Nicolas, C; Wattiau, P; Fretin, D; Whatmore, A M; Cloeckaert, A; Blasco, J M; Moriyon, I; Saegerman, C; Muma, J B; Al Dahouk, S; Neubauer, H; Letesson, J-J

    2011-11-01

    Following the recent discovery of new Brucella strains from different animal species and from the environment, ten Brucella species are nowadays included in the genus Brucella. Although the intracellular trafficking of Brucella is well described, the strategies developed by Brucella to survive and multiply in phagocytic and non-phagocytic cells, particularly to access nutriments during its intracellular journey, are still largely unknown. Metabolism and virulence of Brucella are now considered to be two sides of the same coin. Mechanisms presiding to the colonization of the pregnant uterus in different animal species are not known. Vaccination is the cornerstone of control programs in livestock and although the S19, RB51 (both in cattle) and Rev 1 (in sheep and goats) vaccines have been successfully used worldwide, they have drawbacks and thus the ideal brucellosis vaccine is still very much awaited. There is no vaccine available for pigs and wildlife. Animal brucellosis control strategies differ in the developed and the developing world. Most emphasis is put on eradication and on risk analysis to avoid the re-introduction of Brucella in the developed world. Information related to the prevalence of brucellosis is still scarce in the developing world and control programs are rarely implemented. Since there is no vaccine available for humans, prevention of human brucellosis relies on its control in the animal reservoir. Brucella is also considered to be an agent to be used in bio- and agroterrorism attacks. At the animal/ecosystem/human interface it is critical to reduce opportunities for Brucella to jump host species as already seen in livestock, wildlife and humans. This task is a challenge for the future in terms of veterinary public health, as for wildlife and ecosystem managers and will need a "One Health" approach to be successful.

  2. Global human appropriation of net primary production doubled in the 20th century.

    PubMed

    Krausmann, Fridolin; Erb, Karl-Heinz; Gingrich, Simone; Haberl, Helmut; Bondeau, Alberte; Gaube, Veronika; Lauk, Christian; Plutzar, Christoph; Searchinger, Timothy D

    2013-06-18

    Global increases in population, consumption, and gross domestic product raise concerns about the sustainability of the current and future use of natural resources. The human appropriation of net primary production (HANPP) provides a useful measure of human intervention into the biosphere. The productive capacity of land is appropriated by harvesting or burning biomass and by converting natural ecosystems to managed lands with lower productivity. This work analyzes trends in HANPP from 1910 to 2005 and finds that although human population has grown fourfold and economic output 17-fold, global HANPP has only doubled. Despite this increase in efficiency, HANPP has still risen from 6.9 Gt of carbon per y in 1910 to 14.8 GtC/y in 2005, i.e., from 13% to 25% of the net primary production of potential vegetation. Biomass harvested per capita and year has slightly declined despite growth in consumption because of a decline in reliance on bioenergy and higher conversion efficiencies of primary biomass to products. The rise in efficiency is overwhelmingly due to increased crop yields, albeit frequently associated with substantial ecological costs, such as fossil energy inputs, soil degradation, and biodiversity loss. If humans can maintain the past trend lines in efficiency gains, we estimate that HANPP might only grow to 27-29% by 2050, but providing large amounts of bioenergy could increase global HANPP to 44%. This result calls for caution in refocusing the energy economy on land-based resources and for strategies that foster the continuation of increases in land-use efficiency without excessively increasing ecological costs of intensification.

  3. Human isolates of Listeria monocytogenes in Sweden during half a century (1958-2010).

    PubMed

    Lopez-Valladares, G; Tham, W; Parihar, V Singh; Helmersson, S; Andersson, B; Ivarsson, S; Johansson, C; Ringberg, H; Tjernberg, I; Henriques-Normark, B; Danielsson-Tham, M-L

    2014-11-01

    Isolates of Listeria monocytogenes (n = 932) isolated in Sweden during 1958-2010 from human patients with invasive listeriosis were characterized by serotyping and pulsed-field gel electrophoresis (PFGE) (AscI). Of the 932 isolates, 183 different PFGE types were identified, of which 83 were each represented by only one isolate. In all, 483 serovar 1/2a isolates were distributed over 114 PFGE types; 90 serovar 1/2b isolates gave 32 PFGE types; 21 serovar 1/2c isolates gave nine PFGE types; three serovar 3b isolates gave one PFGE type; and, 335 serovar 4b isolates gave 31 PFGE types. During the 1980s in Sweden, several serovar 4b cases were associated with the consumption of European raw soft cheese. However, as cheese-production hygiene has improved, the number of 4b cases has decreased. Since 1996, serovar 1/2a has been the dominant L. monocytogenes serovar in human listeriosis in Sweden. Therefore, based on current serovars and PFGE types, an association between human cases of listeriosis and the consumption of vacuum-packed gravad and cold-smoked salmon is suggested.

  4. Creativity and Innovation in Open and Distance Education: A Paradigm for Human Development in the 21st Century for Nation-Building in Nigeria

    ERIC Educational Resources Information Center

    Ogeh, Obitor W. M.; Chiemeka, Nnorom

    2015-01-01

    This paper is focused on creativity and innovation in open and distance education as a paradigm for human development in the twenty first century for nation-building in Nigeria. The paper looks at the open/distance education programme and its unconventional method of delivery in educating the educationally less privileged. The paper is of the…

  5. Facing Human Capital Challenges of the 21st Century: Education and Labor Market Initiatives in Lebanon, Oman, Qatar, and the United Arab Emirates

    ERIC Educational Resources Information Center

    Gonzalez, Gabriella; Karoly, Lynn A.; Constant, Louay; Salem, Hanine; Goldman, Charles A.

    2008-01-01

    Countries in the Arab region are faced with the challenge of developing their populations' skills and technical knowledge, or human capital, in order to compete in the 21st century global economy. The authors describe the education and labor market initiatives implemented or under way in four countries in the Arab region -- Lebanon, Oman, Qatar,…

  6. Facing Human Capital Challenges of the 21st Century: Education and Labor Market Initiatives in Lebanon, Oman, Qatar, and the United Arab Emirates

    ERIC Educational Resources Information Center

    Gonzalez, Gabriella; Karoly, Lynn A.; Constant, Louay; Salem, Hanine; Goldman, Charles A.

    2008-01-01

    Countries in the Arab region are faced with the challenge of developing their populations' skills and technical knowledge, or human capital, in order to compete in the 21st century global economy. The authors describe the education and labor market initiatives implemented or under way in four countries in the Arab region -- Lebanon, Oman, Qatar,…

  7. Overview and research agenda arising from the 7th World Workshop on Oral Health and Disease in AIDS.

    PubMed

    Tappuni, A R; Shiboski, C

    2016-04-01

    The Research Agenda generated by the 7th World Workshop on Oral Health and Disease in AIDS (WW7) is delivered in this paper. Panels of international experts presided over nine workshops that constituted the conference held in November 2014 in Hyderabad, India. The main goal of the Workshop was to bring together clinician and scientists interested in the subject to debate with world-wide perspectives current issues related to the oral manifestations in HIV/AIDS. The workshops were structured around three themes; basic science, clinical/translational science and social science and were attended by 135 participants from 31 countries. The research questions debated at the workshops are presented in nine consensus papers published in this issue and are summarised in this paper along with an outline of the identified research needs in the field.

  8. UV-induced Oxygen Removal for Photostable High Efficiency PTB7-Th: PC71BM Photovoltaic Cells.

    PubMed

    Liu, Quan; Mantilla-Perez, Paola; Montes Bajo, Miguel; Romero-Gomez, Pablo; Martorell, Jordi

    2016-10-03

    Solution-processed ZnO sol-gel or nanoparticles are widely used as the electron transporting layer (ETL) in optoelectronic devices. However, chemisorbed oxygen on the ZnO layer surface has been shown to be detrimental for the device performance as well as stability. Herein, we demonstrate that a chemisorbed oxygen removal based on a UV illumination of the ZnO surface layer under a nitrogen atmosphere can, simultaneously, improve power conversion efficiency and photostability of PTB7-Th: PC71BM based inverted polymer solar cells. By a systematic study of such UV illumination procedure, we obtained optimal conditions where, both, the cell efficiency and stability were improved. We fabricated cells with a power conversion efficiency higher than 9.8%, and with a T80 lifetime larger than 500 hours, corresponding to about a 2.5-fold enhancement relative to non-UV treated ZnO reference devices.

  9. Incorporation of perineural invasion of gastric carcinoma into the 7th edition tumor-node-metastasis staging system.

    PubMed

    Jiang, Nan; Deng, Jing-Yu; Liu, Yong; Ke, Bin; Liu, Hong-Gen; Liang, Han

    2014-09-01

    The aim of this study was to determine the prognostic value of perineural invasion (PNI) in patients with gastric cancer who underwent curative resection. We retrospectively analyzed 518 patients who had undergone curative gastrectomy. Paraffin sections of surgical specimens from all patients were stained with hematoxylin and eosin. PNI was defined when carcinoma cells infiltrated into the perineurium or neural fascicles. Patients with PNI had a significantly larger tumors (≥5.0 cm), lymphatic venous invasion (positive), deeper tumor invasion (T4), more number of lymph node metastases (N3), and higher tumor stage (III). Regarding survival, multivariate analysis showed that PNI emerged as an independent prognostic factor for survival (hazard ratio (HR) = 1.901, P < 0.001). We incorporated the PNI into the 7th edition tumor-node-metastasis (TNM) staging system. Comparing with the 7th edition staging system, the redefinition of TPNI stage had higher -2loglikelihood value (-2loglikelihood = 3,492.259) and lower HR and 95 % confidence interval (CI) (HR = 1.955, 95 % CI = 1.630-2.343); redefinition of NPNI and TNMIIIPNI stage both had lower -2loglikelihood value (-2loglikelihood = 3,306.608; -2loglikelihood = 2,535.151) and higher HR and 95 % CI (HR = 1.879, 95 % CI = 1.720-2.053; HR = 2.268, 95 % CI = 1.900-2.707), which represented the optimum prognostic stratification, together with better homogeneity, discriminatory ability. Our results showed that the frequency of PNI was high in patients with gastric cancer who underwent curative gastrectomy and the proportion of PNI positivity increased with progression and clinical stage of disease. PNI may be useful in detecting patients who had poor prognosis after curative resection in gastric cancer and it should be incorporated into TNM staging.

  10. A social way to experience a scientific event: Twitter use at the 7th European Public Health Conference.

    PubMed

    Bert, Fabrizio; Zeegers Paget, Dineke; Scaioli, Giacomo

    2016-03-01

    Many studies have analysed Twitter's use by attendees of scientific meetings and the characteristics of conference-related messages and most active attendees. Despite these previous reports, to date no studies have described the use of Twitter during Public Health conferences. For this reason, we decided to perform an analysis of Twitter's use during the 7th European Public Health (EPH) Conference (Glasgow, November 2014). All the tweets published from 21 July to 2 December 2014 and including the hashtag #ephglasgow were retrieved and much information (author, date, retweets, favourites, mentions, presence of pictures and/or external links, content type and topics) was analysed. A total of 1066 tweets with the hashtag #ephglasgow were retrieved; 86.3% of these were tweeted during the conference. A total of 209 single accounts tweeted, pictures were present in 29.7% tweets while external links were published in 13.8%. Conference speakers were mentioned in around 30% of tweets. Almost 60% of the tweets had a session-related content. Considering only the session-related tweets, one-third had as the main topic 'Health inequalities and migrant and ethnic minority health', while 20% were 'Health policy and health economics' oriented. The results of this study have demonstrated a massive use of Twitter by conference attendees during the 7th EPH conference, and that conference attendees are willing to share quotes and impressions particularly about conference-related topics. It is mandatory for conference organisers to promote online discussion and knowledge dissemination during conferences, especially in the public health field. © 2015 the Nordic Societies of Public Health.

  11. Human preservation techniques in anatomy: A 21st century medical education perspective.

    PubMed

    Balta, Joy Y; Cronin, Michael; Cryan, John F; O'Mahony, Siobhain M

    2015-09-01

    Anatomy is the cornerstone of education for healthcare professionals with the use of human material providing an excellent teaching tool in the modern curricula. The ability and quality of preservation of human remains has enabled such use. The introduction of formaldehyde as a preservative in 1893 was an important step in the history of preservation. With the European Union directive on the use of formaldehyde and its expected banning, anatomists are trying to find a more convenient and safe substitute. In this review, we compare the different techniques used based on the need for embalming, fixative used, period of preservation and the features of the embalmed specimen. The fact that embalming is used in different disciplines, multiple purposes and described in different languages has led to the development of ambiguous interchangeable terminology. Overall, there is a lack of information specifically classifying, listing and comparing different embalming techniques, and this may be due to the fact that no internationally recognized experimental standards are adhered to in this field. Anatomists strive to find an embalming technique that allows the preserved specimen to accurately resemble the living tissue, preserve the body for a long period of time and reduces health risk concerns related to working with cadavers. There is a need for embalming to shift to an independent modern day science with well-founded research at the heart of it. While this may take time and agreement across nations, we feel that this review adds to the literature to provide a variety of different methods that can be employed for human tissue preservation depending on the desired outcome.

  12. Physical attractiveness and reproductive success in humans: Evidence from the late 20 century United States.

    PubMed

    Jokela, Markus

    2009-09-01

    Physical attractiveness has been associated with mating behavior, but its role in reproductive success of contemporary humans has received surprisingly little attention. In the Wisconsin Longitudinal Study (1244 women, 997 men born between 1937 and 1940) we examined whether attractiveness assessed from photographs taken at age ~18 predicted the number of biological children at age 53-56. In women, attractiveness predicted higher reproductive success in a nonlinear fashion, so that attractive (second highest quartile) women had 16% and very attractive (highest quartile) women 6% more children than their less attractive counterparts. In men, there was a threshold effect so that men in the lowest attractiveness quartile had 13% fewer children than others who did not differ from each other in the average number of children. These associations were partly but not completely accounted for by attractive participants' increased marriage probability. A linear regression analysis indicated relatively weak directional selection gradient for attractiveness (β=0.06 in women, β=0.07 in men). These findings indicate that physical attractiveness may be associated with reproductive success in humans living in industrialized settings.

  13. [Physical anthropology and human "zoos": the exhibition of natives as a scientific popularization practice on the threshold of the 20th century].

    PubMed

    Arteaga, Juanma Sánchez

    2010-01-01

    All along the nineteenth century different anthropological exhibitions were held in many countries, in which people from a number of indigenous communities, especially transported from their homeland for the occasion, were exhibited publicly, both for citizenship's instruction and for specialists's "in vivo" studies on human biology. This paper presents a brief description of some of these scientific shows, and tries to relate them to contemporary human biology theories.

  14. Validation of the 7th edition TNM staging system for hepatocellular carcinoma: an analysis of 8,828 patients in a single medical center.

    PubMed

    Kee, Kwong-Ming; Wang, Jing-Houng; Lin, Chih-Yun; Wang, Chih-Chi; Cheng, Yu-Fan; Lu, Sheng-Nan

    2013-09-01

    Major modification of the 7th tumor-node-metastasis (TNM) staging system for hepatocellular carcinoma (HCC) was divided into 6th stage IIIA to 7th IIIA (multiple tumors, any>5 cm) and IIIB (tumors involving a major vessel). This study aimed to validate 6th and 7th TNM systems in prognostic prediction, then analyze the impact of time, Child-Pugh classification and treatment modalities in survival. A total of 5,611 and 3,217 HCC patients were enrolled between 1986-2002 (past period) and 2003-2010 (recent period), respectively. The Akaike information criteria (AIC) within a Cox proportional hazard regression model were used to demonstrate the discriminatory ability for staging systems. The 1-, 3-, and 5-year survival rates of past and recent periods were 44.8, 24.9, 17.1%, and 65.5, 44.5, 34.6%, respectively (p<0.001). Rates of smaller HCC detection and received curative treatment were significantly higher in the recent period than in the past period (p<0.001). Survival rates were different in each Child-Pugh class (all p<0.001). Patients receiving curative treatment had highest survival rates, followed by non-curative treatment, and untreated patients (p<0.05). In both periods, significant differences in survival curves existed between each of the stages in the 6th and 7th TNM staging (all p<0.05), and also between IIIA and IIIB in the 7th TNM (p<0.001). The AIC of two periods in the 6th and 7th TNM systems were decreased, with 77,895 and 77,630, and 19,162 and 19,135, respectively. The 7th TNM provided better prognostic prediction than the 6th TNM after dividing into IIIA and IIIB. Survival rates of HCC have been improving in recent decades.

  15. Combining Human and Machine Learning to Map Cropland in the 21st Century's Major Agricultural Frontier

    NASA Astrophysics Data System (ADS)

    Estes, L. D.; Debats, S. R.; Caylor, K. K.; Evans, T. P.; Gower, D.; McRitchie, D.; Searchinger, T.; Thompson, D. R.; Wood, E. F.; Zeng, L.

    2016-12-01

    In the coming decades, large areas of new cropland will be created to meet the world's rapidly growing food demands. Much of this new cropland will be in sub-Saharan Africa, where food needs will increase most and the area of remaining potential farmland is greatest. If we are to understand the impacts of global change, it is critical to accurately identify Africa's existing croplands and how they are changing. Yet the continent's smallholder-dominated agricultural systems are unusually challenging for remote sensing analyses, making accurate area estimates difficult to obtain, let alone important details related to field size and geometry. Fortunately, the rapidly growing archives of moderate to high-resolution satellite imagery hosted on open servers now offer an unprecedented opportunity to improve landcover maps. We present a system that integrates two critical components needed to capitalize on this opportunity: 1) human image interpretation and 2) machine learning (ML). Human judgment is needed to accurately delineate training sites within noisy imagery and a highly variable cover type, while ML provides the ability to scale and to interpret large feature spaces that defy human comprehension. Because large amounts of training data are needed (a major impediment for analysts), we use a crowdsourcing platform that connects amazon.com's Mechanical Turk service to satellite imagery hosted on open image servers. Workers map visible fields at pre-assigned sites, and are paid according to their mapping accuracy. Initial tests show overall high map accuracy and mapping rates >1800 km2/hour. The ML classifier uses random forests and randomized quasi-exhaustive feature selection, and is highly effective in classifying diverse agricultural types in southern Africa (AUC > 0.9). We connect the ML and crowdsourcing components to make an interactive learning framework. The ML algorithm performs an initial classification using a first batch of crowd-sourced maps, using

  16. Accelerating the Development of 21st-Century Toxicology: Outcome of a Human Toxicology Project Consortium Workshop

    PubMed Central

    Stephens, Martin L.; Barrow, Craig; Andersen, Melvin E.; Boekelheide, Kim; Carmichael, Paul L.; Holsapple, Michael P.; Lafranconi, Mark

    2012-01-01

    The U.S. National Research Council (NRC) report on “Toxicity Testing in the 21st century” calls for a fundamental shift in the way that chemicals are tested for human health effects and evaluated in risk assessments. The new approach would move toward in vitro methods, typically using human cells in a high-throughput context. The in vitro methods would be designed to detect significant perturbations to “toxicity pathways,” i.e., key biological pathways that, when sufficiently perturbed, lead to adverse health outcomes. To explore progress on the report’s implementation, the Human Toxicology Project Consortium hosted a workshop on 9–10 November 2010 in Washington, DC. The Consortium is a coalition of several corporations, a research institute, and a non-governmental organization dedicated to accelerating the implementation of 21st-century Toxicology as aligned with the NRC vision. The goal of the workshop was to identify practical and scientific ways to accelerate implementation of the NRC vision. The workshop format consisted of plenary presentations, breakout group discussions, and concluding commentaries. The program faculty was drawn from industry, academia, government, and public interest organizations. Most presentations summarized ongoing efforts to modernize toxicology testing and approaches, each with some overlap with the NRC vision. In light of these efforts, the workshop identified recommendations for accelerating implementation of the NRC vision, including greater strategic coordination and planning across projects (facilitated by a steering group), the development of projects that test the proof of concept for implementation of the NRC vision, and greater outreach and communication across stakeholder communities. PMID:21948868

  17. Biotic and Human Vulnerability to Projected Changes in Ocean Biogeochemistry over the 21st Century

    PubMed Central

    Mora, Camilo; Wei, Chih-Lin; Rollo, Audrey; Amaro, Teresa; Baco, Amy R.; Billett, David; Bopp, Laurent; Chen, Qi; Collier, Mark; Danovaro, Roberto; Gooday, Andrew J.; Grupe, Benjamin M.; Halloran, Paul R.; Ingels, Jeroen; Jones, Daniel O. B.; Levin, Lisa A.; Nakano, Hideyuki; Norling, Karl; Ramirez-Llodra, Eva; Rex, Michael; Ruhl, Henry A.; Smith, Craig R.; Sweetman, Andrew K.; Thurber, Andrew R.; Tjiputra, Jerry F.; Usseglio, Paolo; Watling, Les; Wu, Tongwen; Yasuhara, Moriaki

    2013-01-01

    Ongoing greenhouse gas emissions can modify climate processes and induce shifts in ocean temperature, pH, oxygen concentration, and productivity, which in turn could alter biological and social systems. Here, we provide a synoptic global assessment of the simultaneous changes in future ocean biogeochemical variables over marine biota and their broader implications for people. We analyzed modern Earth System Models forced by greenhouse gas concentration pathways until 2100 and showed that the entire world's ocean surface will be simultaneously impacted by varying intensities of ocean warming, acidification, oxygen depletion, or shortfalls in productivity. In contrast, only a small fraction of the world's ocean surface, mostly in polar regions, will experience increased oxygenation and productivity, while almost nowhere will there be ocean cooling or pH elevation. We compiled the global distribution of 32 marine habitats and biodiversity hotspots and found that they would all experience simultaneous exposure to changes in multiple biogeochemical variables. This superposition highlights the high risk for synergistic ecosystem responses, the suite of physiological adaptations needed to cope with future climate change, and the potential for reorganization of global biodiversity patterns. If co-occurring biogeochemical changes influence the delivery of ocean goods and services, then they could also have a considerable effect on human welfare. Approximately 470 to 870 million of the poorest people in the world rely heavily on the ocean for food, jobs, and revenues and live in countries that will be most affected by simultaneous changes in ocean biogeochemistry. These results highlight the high risk of degradation of marine ecosystems and associated human hardship expected in a future following current trends in anthropogenic greenhouse gas emissions. PMID:24143135

  18. Biotic and human vulnerability to projected changes in ocean biogeochemistry over the 21st century.

    PubMed

    Mora, Camilo; Wei, Chih-Lin; Rollo, Audrey; Amaro, Teresa; Baco, Amy R; Billett, David; Bopp, Laurent; Chen, Qi; Collier, Mark; Danovaro, Roberto; Gooday, Andrew J; Grupe, Benjamin M; Halloran, Paul R; Ingels, Jeroen; Jones, Daniel O B; Levin, Lisa A; Nakano, Hideyuki; Norling, Karl; Ramirez-Llodra, Eva; Rex, Michael; Ruhl, Henry A; Smith, Craig R; Sweetman, Andrew K; Thurber, Andrew R; Tjiputra, Jerry F; Usseglio, Paolo; Watling, Les; Wu, Tongwen; Yasuhara, Moriaki

    2013-10-01

    Ongoing greenhouse gas emissions can modify climate processes and induce shifts in ocean temperature, pH, oxygen concentration, and productivity, which in turn could alter biological and social systems. Here, we provide a synoptic global assessment of the simultaneous changes in future ocean biogeochemical variables over marine biota and their broader implications for people. We analyzed modern Earth System Models forced by greenhouse gas concentration pathways until 2100 and showed that the entire world's ocean surface will be simultaneously impacted by varying intensities of ocean warming, acidification, oxygen depletion, or shortfalls in productivity. In contrast, only a small fraction of the world's ocean surface, mostly in polar regions, will experience increased oxygenation and productivity, while almost nowhere will there be ocean cooling or pH elevation. We compiled the global distribution of 32 marine habitats and biodiversity hotspots and found that they would all experience simultaneous exposure to changes in multiple biogeochemical variables. This superposition highlights the high risk for synergistic ecosystem responses, the suite of physiological adaptations needed to cope with future climate change, and the potential for reorganization of global biodiversity patterns. If co-occurring biogeochemical changes influence the delivery of ocean goods and services, then they could also have a considerable effect on human welfare. Approximately 470 to 870 million of the poorest people in the world rely heavily on the ocean for food, jobs, and revenues and live in countries that will be most affected by simultaneous changes in ocean biogeochemistry. These results highlight the high risk of degradation of marine ecosystems and associated human hardship expected in a future following current trends in anthropogenic greenhouse gas emissions.

  19. Industrializing the near-earth asteroids: Speculations on human activities in space in the latter half of the 21st century

    NASA Technical Reports Server (NTRS)

    Sercel, Joel C.

    1990-01-01

    The use of solar system resources for human industry can be viewed as a natural extension of the continual growth of our species' habitat. Motivations for human activities in space can be discussed in terms of five distinct areas: (1) information processing and collection; (2) materials processing; (3) energy production to meet terrestrial power needs; (4) the use of extraterrestrial materials; and (5) disaster avoidance. When considering 21st-Century activities in space, each of these basic motivations must be treated in light of issues likely to be relevant to the 21st-Century earth. Many of the problems facing 21st-Century earth may stem from the need to maintain the world population of 8 to 10 billion people as is projected from expected growth rates. These problems are likely to include managing the impact of industrial processes on the terrestrial biosphere while providing adequate energy production and material goods for the growing population. The most important human activities in space in the latter half of the 21st Century may be associated with harnessing the resources of the near-earth asteroids for industrial processes. These above topics are discussed with an emphasis on space industrialization.

  20. Being There & Getting Back Again: Half a Century of Deep Ocean Research & Discovery with the Human Occupied Vehicle "Alvin"

    NASA Astrophysics Data System (ADS)

    German, C. R.; Fornari, D. J.; Fryer, P.; Girguis, P. R.; Humphris, S. E.; Kelley, D. S.; Tivey, M.; Van Dover, C. L.; Von Damm, K.

    2012-12-01

    In 2013, Alvin returns to service after significant observational and operational upgrades supported by the NSF, NAVSEA & NOAA. Here we review highlights of the first half-century of deep submergence science conducted by Alvin, describe some of the most significant improvements for the new submarine and discuss the importance of these new capabilities for 21st century ocean science and education. Alvin has a long history of scientific exploration, discovery and intervention at the deep seafloor: in pursuit of hypothesis-driven research and in response to human impacts. One of Alvin's earliest achievements, at the height of the Cold War, was to help locate & recover an H-bomb in the Mediterranean, while the last dives completed, just ahead of the current refit, were to investigate the impacts of the Deep Water Horizon oil spill. Alvin has excelled in supporting a range of Earth & Life Science programs including, in the late 1970s, first direct observations and sampling of deep-sea hydrothermal vents and the unusual fauna supported by microbial chemosynthesis. The 1980s saw expansion of Alvin's dive areas to newly discovered hot-springs in the Atlantic & NE Pacific, Alvin's first dives to the wreck of RMS Titanic and its longest excursions away from WHOI yet, via Loihi Seamount (Hawaii) to the Mariana Trench. The 1990s saw Alvin's first event-response dives to sites where volcanic eruptions had just occurred at the East Pacific Rise & Juan de Fuca Ridge while the 2000s saw Alvin discover novel off-axis venting at Lost City. Observations from these dives fundamentally changed our views of volcanic and microbial processes within young ocean crust and even the origins of life! In parallel, new deep submergence capabilities, including manipulative experiments & sensor development, relied heavily on testing using Alvin. Recently, new work has focused on ocean margins where fluid flow from the seafloor results in the release of hydrocarbons and other chemical species that

  1. An Altair Overview: Designing a Lunar Lander for 21st Century Human Space Exploration

    NASA Technical Reports Server (NTRS)

    Brown, Kendall K.; Connolly, John F.

    2012-01-01

    Altair, the lunar lander element of NASA's Constellation program, was conducted in a different design environment than many other NASA projects of similar scope. Because of this relatively unique approach, there are a number of significant success stories that should be considered during the development of any future lunar landers or human spacecraft. This paper is divided into two separate themes; the first is the approach used during the conceptual design studies, including the systematic analysis cycles and the decision making process associated with each: and the second is a summary of the resulting lessons learned that were compiled after looking back at the lifetime of the Project. Altair was terminated before entering Phase B of its design, and was often criticized for being a very heavy and very large vehicle. While there was specific rationale for all of the decisions that led up to that configuration, future design cycles were specifically planned to re-address the mass challenge. Had the project continued, the deliberate, stepwise design process would have converged on an optimized lander design that balanced mass, risk, cost and capabilities. Some of the specific items that will be addressed in this paper include project development strategy, organizational approach and team dynamics, risk-informed design process, mission architecture constraints, mission key driving requirements, model-based systems engineering process, configuration studies, contingency considerations, subsystem overviews and key trade studies. The paper will conclude with a summary of the lessons identified during the Altair project and make suggestions for application to future studies.

  2. Present-day central African forest is a legacy of the 19th century human history

    PubMed Central

    Morin-Rivat, Julie; Fayolle, Adeline; Favier, Charly; Bremond, Laurent; Gourlet-Fleury, Sylvie; Bayol, Nicolas; Lejeune, Philippe; Beeckman, Hans; Doucet, Jean-Louis

    2017-01-01

    The populations of light-demanding trees that dominate the canopy of central African forests are now aging. Here, we show that the lack of regeneration of these populations began ca. 165 ya (around 1850) after major anthropogenic disturbances ceased. Since 1885, less itinerancy and disturbance in the forest has occurred because the colonial administrations concentrated people and villages along the primary communication axes. Local populations formerly gardened the forest by creating scattered openings, which were sufficiently large for the establishment of light-demanding trees. Currently, common logging operations do not create suitable openings for the regeneration of these species, whereas deforestation degrades landscapes. Using an interdisciplinary approach, which included paleoecological, archaeological, historical, and dendrological data, we highlight the long-term history of human activities across central African forests and assess the contribution of these activities to present-day forest structure and composition. The conclusions of this sobering analysis present challenges to current silvicultural practices and to those of the future. DOI: http://dx.doi.org/10.7554/eLife.20343.001 PMID:28093097

  3. Metabolomics: building on a century of biochemistry to guide human health

    PubMed Central

    German, J. Bruce; Hammock, Bruce D.; Watkins, Steven M.

    2006-01-01

    Medical diagnosis and treatment efficacy will improve significantly when a more personalized system for health assessment is implemented. This system will require diagnostics that provide sufficiently detailed information about the metabolic status of individuals such that assay results will be able to guide food, drug and lifestyle choices to maintain or improve distinct aspects of health without compromising others. Achieving this goal will use the new science of metabolomics – comprehensive metabolic profiling of individuals linked to the biological understanding of human integrative metabolism. Candidate technologies to accomplish this goal are largely available, yet they have not been brought into practice for this purpose. Metabolomic technologies must be sufficiently rapid, accurate and affordable to be routinely accessible to both healthy and acutely ill individuals. The use of metabolomic data to predict the health trajectories of individuals will require bioinformatic tools and quantitative reference databases. These databases containing metabolite profiles from the population must be built, stored and indexed according to metabolic and health status. Building and annotating these databases with the knowledge to predict how a specific metabolic pattern from an individual can be adjusted with diet, drugs and lifestyle to improve health represents a logical application of the biochemistry knowledge that the life sciences have produced over the past 100 years. PMID:16680201

  4. A forensic hypothesis for the mystery of al-Hasan’s death in the 7th century: Mercury(I) chloride intoxication

    PubMed Central

    Burke, Nicole; Golas, Mitchell; Raafat, Cyrus L.

    2015-01-01

    The puzzle of a mysterious death in the Middle Ages has been hypothesized in terms of contemporary forensic legal and scientific methods. That al-Hasan ibn-‘Ali died in 669 aged just 45 has been forensically analyzed based on written sources that dictate eyewitness accounts of historical events. The report of the contemporaneous poisoning of another individual who resided under the same household as al-Hasan’s and experienced similar, yet non-lethal, symptoms has served as the beginning of the analysis. In light of ancient (medieval) documents and through using mineralogical, medical, and chemical facts, it has been hypothesized that mineral calomel (mercury(I) chloride, Hg2Cl2) from a certain region in the Byzantine Empire (present-day western Turkey) was the substance primarily responsible for the murder of al-Hasan. PMID:26377933

  5. "Relating in a Global Community." Proceedings of the International Conference on Counseling in the 21st Century (7th, Sydney, Australia, December 29-31, 1998.)

    ERIC Educational Resources Information Center

    1998

    The papers presented at this conference consider the many roles counselors play in people's lives throughout their lifespan. The age of technology has aided the practice of counseling in becoming international in scope, although there are different functional frameworks that exist in various political, economic, social, and value systems in world…

  6. A forensic hypothesis for the mystery of al-Hasan's death in the 7th century: Mercury(I) chloride intoxication.

    PubMed

    Burke, Nicole; Golas, Mitchell; Raafat, Cyrus L; Mousavi, Aliyar

    2016-07-01

    The puzzle of a mysterious death in the Middle Ages has been hypothesized in terms of contemporary forensic legal and scientific methods. That al-Hasan ibn-'Ali died in 669 aged just 45 has been forensically analyzed based on written sources that dictate eyewitness accounts of historical events. The report of the contemporaneous poisoning of another individual who resided under the same household as al-Hasan's and experienced similar, yet non-lethal, symptoms has served as the beginning of the analysis. In light of ancient (medieval) documents and through using mineralogical, medical, and chemical facts, it has been hypothesized that mineral calomel (mercury(I) chloride, Hg2Cl2) from a certain region in the Byzantine Empire (present-day western Turkey) was the substance primarily responsible for the murder of al-Hasan. © The Author(s) 2015.

  7. Sustainability of water uses in managed hydrosystems: human- and climate-induced changes for the mid-21st century

    NASA Astrophysics Data System (ADS)

    Fabre, J.; Ruelland, D.; Dezetter, A.; Grouillet, B.

    2015-09-01

    This paper assesses the sustainability of planned water uses in mesoscale river basins under multiple climate change scenarios, and contributes to determining the possible causes of unsustainability. We propose an assessment grounded in real-world water management issues, with water management scenarios built in collaboration with local water agencies. Furthermore we present an analysis through indicators that relate to management goals and present the implications of climate uncertainty for our results, furthering the significance of our study for water management. A modeling framework integrating hydro-climatic and human dynamics and accounting for interactions between resource and demand was developed and applied in two basins of different scales and with contrasting water uses: the Herault (2500 km2, France) and the Ebro (85 000 km2, Spain) basins. Natural streamflow was evaluated using a conceptual hydrological model. A demand-driven reservoir management model was designed to account for streamflow regulations from the main dams. Human water demand was estimated from time series of demographic, socio-economic and climatic data. Environmental flows were accounted for by defining streamflow thresholds under which withdrawals were strictly limited. Finally indicators comparing water availability to demand at strategic resource and demand nodes were computed. This framework was applied under different combinations of climatic and water use scenarios for the mid-21st century to differentiate the impacts of climate- and human-induced changes on streamflow and water balance. Results showed that objective monthly environmental flows would be guaranteed in current climate conditions in both basins, yet in several areas this could imply limiting human water uses more than once every five years. The impact of the tested climate projections on both water availability and demand could question the water allocations and environmental requirements currently planned for the

  8. Human Values and the Market: The Case of Life Insurance and Death in 19th-Century America.

    ERIC Educational Resources Information Center

    Zelizer, Viviana A.

    1978-01-01

    Explores the development of life insurance programs in the United States during the nineteenth century and traces social attitudes about life insurance from rejection to acceptance. Historical data indicate that life insurance emerged in the late nineteenth century as a form of ritual with which to face death. (Author/DB)

  9. Jupiter 7th Pearl

    NASA Image and Video Library

    2016-12-14

    This image, taken by the JunoCam imager on NASA's Juno spacecraft, highlights the seventh of eight features forming a 'string of pearls' on Jupiter -- massive counterclockwise rotating storms that appear as white ovals in the gas giant's southern hemisphere. Since 1986, these white ovals have varied in number from six to nine. There are currently eight white ovals visible. Since 1986, these white ovals have varied in number from six to nine. There are currently eight white ovals visible. The image was taken on Dec. 11, 2016, at 9:27 a.m. PST (12:27 EST) as the Juno spacecraft performed its third close flyby of the planet. At the time the image was taken, the spacecraft was about 15,300 miles (24,600 kilometers) from Jupiter. http://photojournal.jpl.nasa.gov/catalog/PIA21219

  10. Mycobacterium tuberculosis complex detection in human remains: tuberculosis spread since the 17th century in Rio de Janeiro, Brazil.

    PubMed

    Jaeger, Lauren Hubert; Leles, Daniela; Lima, Valdirene dos Santos; da Silva, Laura da Piedade; Dias, Ondemar; Iñiguez, Alena Mayo

    2012-06-01

    Paleogenetic analysis for tuberculosis (TB) was conducted on bone and sediment samples dating from the 17th to 19th centuries from the archeological site of Nossa Senhora do Carmo Church in Rio de Janeiro, Brazil. Forty samples were analyzed, corresponding to 32 individuals from 28 burials, 22 of primary type and 6 of secondary type. The samples were collected following strict paleogenetic investigation guidelines and submitted to ancient DNA (aDNA) extraction. In order to detect TB infection, aDNA hybridizations with the molecular targets of Mycobacterium tuberculosis complex (MTC) IS6110 and IS1081 were applied. Additionally, the ancestry of individuals was assessed by human mitochondrial DNA (mtDNA) analysis of hypervariable segment I (HVS-I) sequence polymorphisms. The results of aDNA hybridizations demonstrated varying levels of MTC intensity in 17/32 individuals (53.1%), using the IS6110 target. The IS1081 MTC target showed lower sensitivity, confirming TB positivity in 10/32 (31.2%) individuals. The mtDNA analysis allowed the recovery of HVS-I sequences in 23/32 individuals (71.8%). The majority of these individuals (21/23, 91.3%) were of European ancestry, especially in primary burials. Haplogroups U, J, V, T, K, N, H and R, were identified with haplogroup U being the most frequent at 6/23 (26.1%). African and Amerindian mtDNA haplogroups were observed in two individuals in secondary burials. In spite of the ecclesiastic and aristocratic bias of the population of the study, human ancestry analysis revealed the prominent contribution of Europeans in the introduction or spread of TB in the New World.

  11. EDITORIAL: Proceedings of the 7th International LISA Symposium, Barcelona, Spain, 16-20 June 2008 Proceedings of the 7th International LISA Symposium, Barcelona, Spain, 16-20 June 2008

    NASA Astrophysics Data System (ADS)

    Lobo, Alberto; Sopuerta, Carlos F.

    2009-05-01

    In June 2006 the LISA International Science Team (LIST) accepted the bid presented by the Institut d'Estudis Espacials de Catalunya (IEEC) to host the 7th International LISA Symposium. This was during its 11th meeting at the University of Maryland, just before the 6th edition of the symposium started at NASA's Goddard Space Flight Center. The 7th International LISA Symposium took place in the city of Barcelona, Spain, 16-20 June, 2008, in the premises of CosmoCaixa, a modern science museum located in the hills near Tibidabo. Almost 240 delegates registered for the event, a record breaking figure compared to previous editions of the symposium. Many of the most renowned world experts in LISA, gravitational wave science, and astronomy, as well as engineers, attended LISA #7 and produced state of the art presentations, while everybody benefited from the opportunity to have live discussions during the week in a friendly environment. The programme included 31 invited plenary lectures in the mornings, and eight parallel sessions in the afternoons. These were classified into seven major areas of research: LISA Technology, LISA PathFinder, LISA PathFinder Data Analysis, LISA Data Analysis, Gravitational Wave Sources, Cosmology and Fundamental Physics with LISA and Other Gravitational Wave Detectors. Abstracts for 138 communications were received, from which a selection was made by the session convenors which would fit time constraints. Up to 63 posters completed the scientific programme. More details on the programme, including some of the talks, can be found at the symposium website:http://www.ice.cat/research/LISA_Symposium. There was, however, a remarkable add-on: Professor Clifford Will delivered a startling presentation to the general public, who completely filled the Auditori—the main conference room, 320 seats—and were invited to ask questions to the speaker who boldly guided them through the daunting world of Black Holes, Waves of Gravity, and other Warped Ideas

  12. Prognostic Discrepancy of the 6th and 7th UICC N Classification for Lymph Node Staging in Gastric Cancer Patients after Curative Resection

    PubMed Central

    Oh, Sung Jin; Suh, Byoung Jo; Park, Jong Kwon; Oh, Sung Don; Yu, Hang Jong

    2017-01-01

    Background The validity of N classification of the 7th edition of the American Joint Committee on Cancer/Union Internationale contre le Cancer (AJCC/UICC) tumor-node-metastasis (TNM) staging system is still under debate. The purpose of this study was to evaluate the prognostic efficacy of the 7th edition of the AJCC/UICC TNM staging system (focusing on N stage), in comparison with the 6th edition, at a single Eastern institution. Methods We analyzed 1,435 patients with gastric cancer who underwent curative resection performed from September 1998 to August 2003 at the Memorial Jin-Pok Kim Korea Gastric Cancer Center. We analyzed the survival rate of the patients according to the AJCC/UICC 6th and 7th editions, and compared each stage, focusing on N stage. Results Significant differences in the 5-year survival rates were observed between the 6th and the 7th AJCC/UICC staging system. In the 6th edition staging system, the Kaplan-Meier curves discriminated each N stage significantly. In contrast, there was no difference in terms of survival curves for N stage according to the 7th edition, especially between N1 and N2: the Kaplan-Meier plots of survival curves between N1 (77.0%) and N2 (78.1%) stages overlapped significantly (p < 0.05). Conclusion Although the 7th UICC staging system is a more detailed and sophisticated system in the T category, there was no prognostic significance between the pN1 and pN2 stages according to our data. Therefore, we suggest establishing a new UICC staging system taking into consideration the application of the N stage. PMID:28203165

  13. [Case report of acute death on the 7th day due to exposure to the vapor of the insecticide chlorfenapyr].

    PubMed

    Hoshiko, Michiko; Naito, Shinji; Koga, Mitsuaki; Mori, Mihoko; Hara, Kunio; Ishitake, Tatsuya

    2007-04-01

    We present the case of a 55-year-old male agricultural worker who complained of severe general fatigue and hyperperspiration after exposure to an insecticide vapor. He worked in a tea plantation and used chlorfenapyr, a broad spectrum for harmful insects, without any protective mask or clothes. After one day of insecticide spray work, he gradually began to complain of general fatigue, hyperperspiration, nausea and vomiting. At first, he was diagnosed as being dehydrated and was treated with fluid replacement therapy. Although he received this conservative therapy, there was no effect on the above mentioned symptoms. On the 7th day of the onset of his symptoms, his consciousness level deteriorated rapidly and body temperature exceeded 40 degrees C. No cerebral vascular disease or meningitis was observed. Finally, he died despite intensive care. The findings of the clinical course and laboratory data suggest a clinical diagnosis of acute pesticide poisoning due to exposure to chlorfenapyr vapor. We suggest that agricultural workers should use this insecticide with caution and sufficient protective gear.

  14. 7th International Workshop on Osteoarthritis Imaging report: "imaging in OA--now is the time to move ahead".

    PubMed

    Guermazi, A; Eckstein, F; Hunter, D; Roemer, F

    2015-06-01

    The 7th Osteoarthritis Research Society International (OARSI) International Workshop on Osteoarthritis Imaging was held in Reykjavik, Iceland, from July 9-12, 2014; attracting attendees from academia, pharmaceutical and Magnetic resonance imaging (MRI) industries, as well as a large number of young investigators. The Workshop program consisted of six modules, including imaging in osteoarthritis (OA), imaging and pain in OA, new techniques in imaging, risk factors and structural outcomes, anti-nerve growth factor (a-NGF) therapy, and joint replacement. A wealth of data was presented from OA researchers from all over the world and participants gained insightful knowledge on up-to-date research work focusing on imaging of OA. This paper presents a summary of the salient points from the workshop. Identifying the appropriate imaging modality and parameters will be critical for ensuring responsive, reproducible and reliable outcomes for clinical trials. Continued efforts from the OA research community are needed to establish the most effective use of imaging in OA clinical trials, including anti-NGF therapy and joint replacement trials, and to validate newer imaging techniques such as compositional MRI for use in the future clinical trials. Copyright © 2015 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

  15. Assessment of nutrition and physical activity of 6th–7th grade schoolchildren in the city of Vilnius, Lithuania

    PubMed Central

    Skurdenyte, Vaida; Surkiene, Gene; Stukas, Rimantas; Zagminas, Kestutis; Giedraitis, Vincentas

    2015-01-01

    Background Evaluation of eating habits and physical activity is very important for health interventions. Our aim in this study was to assess the characteristics of eating and physical activity of 6–7th grade schoolchildren in the city of Vilnius, Lithuania, as well as the association between dietary habits and physical activity. Methods The study was conducted within the project “Education of healthy diets and physical activity in schools”. The sample consisted of 1008 schoolchildren from 22 schools in the city of Vilnius, and was based on empirical methods, including a questionnaire poll and comparative analysis. Statistical software Stata v.12.1 (Stata corp LP) was used to analyze the data. Results Our study showed that less than half (37.1%) of study participants had physically active leisure time. Boys were significantly more physically active than girls. More than half (61.4%) of children ate breakfast every day. Girls were more likely to eat vegetables and sweets. Schoolchildren who ate vegetables and dairy products as well as those who got enough information about physical activity and spoke about it with their family members were more physically active. Conclusions The results of the study confirmed that schoolchildren were not sufficiently physically active. It was found that low physical activity is related to dietary and other factors, such as lack of information about physical activity and its benefits. PMID:28352688

  16. Adherence and delivery: Implementation quality and program outcomes for the 7th grade keepin’ it REAL program

    PubMed Central

    Pettigrew, Jonathan; Graham, John W.; Miller-Day, Michelle; Hecht, Michael L.; Krieger, Janice L.; Shin, Young Ju

    2014-01-01

    Poor implementation quality (IQ) is known to reduce program effects making it important to consider IQ for evaluation and dissemination of prevention programs. However, less is known about the ways specific implementation variables relate to outcomes. In this study, two versions of the keepin’ it REAL, 7th grade drug prevention intervention were implemented in 78 classrooms in 25 schools in rural districts in Pennsylvania and Ohio. IQ was measured through observational coding of 276 videos. IQ variables included adherence to the curriculum, teacher engagement (attentiveness, enthusiasm, seriousness, clarity, positivity), student engagement (attention, participation), and a global rating of teacher delivery quality. Factor analysis showed that teacher engagement, student engagement, and delivery quality formed one factor, which was labeled delivery. A second factor was adherence to the curriculum. Self-report student surveys measured substance use, norms (beliefs about prevalence and acceptability of use), and efficacy (beliefs about one’s ability to refuse substance offers) at two waves (pretest, immediate posttest). Mixed model regression analysis which accounted for missing data and controlled for pretest levels examined implementation quality’s effects on individual level outcomes, statistically controlling for cluster level effects. Results show that when implemented well, students show positive outcomes compared to students receiving a poorly implemented program. Delivery significantly influenced substance use and norms, but not efficacy. Adherence marginally significantly predicted use and significantly predicted norms, but not efficacy. Findings underscore the importance of comprehensively measuring and accounting for IQ, particularly delivery, when evaluating prevention interventions. PMID:24442403

  17. (137)Cs concentrations in Atlantic and western Antarctic surface waters: results of the 7th Ukrainian Antarctic Expedition, 2002.

    PubMed

    Gulin, S B; Stokozov, N A

    2005-01-01

    The latitudinal distribution of (137)Cs in the Atlantic--western Antarctic surface waters was studied during the 7th Ukrainian Antarctic Expedition in January--May 2002. The (137)Cs concentrations have also been measured in the upper ice of the coastal glacier Woozle Hill located near the Ukrainian Antarctic station "Akademik Vernadsky" (western Antarctica, 65 degrees 15' S-64 degrees 16' W). Comparison of these data with results of previous same-route expeditions SWEDARP (Swedish Antarctic Research Expedition, 1988/1989) and the French R/V "Jeanne d'Arc" (1992/1993), has shown practically parallel changes of (137)Cs surface concentrations between 40 degrees N and 20 degrees S, pointing to decrease of (137)Cs radioactivity at these latitudes with an apparent half-life of 10--15 years (12.5+/-2.1 years on average). This suggests that decrease of (137)Cs surface concentration within this latitude band is controlled, besides the radioactive decay of (137)Cs (half-life=30 years), by vertical mixing of the upper water masses. South of 20 degrees S, the (137)Cs concentrations in surface water have decreased more rapidly because of the influence of the less contaminated Antarctic waters. At 50--60 degrees S and near the Antarctic coast, the (137)Cs activity in 2002 was similar to those measured during the SWEDARP and "Jeanne d'Arc" expeditions, suggesting an additional input of (137)Cs to these waters from the melted ice from the adjacent glaciers.

  18. Bond Strength of 5th, 6th and 7th Generation Bonding Agents to Intracanal Dentin of Primary Teeth

    PubMed Central

    Afshar, Hossein; Baradaran Nakhjavani, Yahya; Rahro Taban, Sedighe; Baniameri, Zahra; Nahvi, Azam

    2015-01-01

    Objectives: This in-vitro study sought to assess the push-out bond strength of a total etch and 2 self-etch bonding systems to intracanal dentin of primary anterior teeth (PAT). Materials and Methods: Thirty-six primary anterior teeth were randomly divided into 3 groups of 5th generation (Single Bond 2), 6th generation (Clearfil SE) and 7th generation (Single Bond Universal) bonding agents. The canal orifice was restored with composite resin and the push-out test was carried out to assess the bond strength. After applying the push-out load, specimens were evaluated under a light microscope at 40X magnification. One-way ANOVA and log-rank test on Kaplan-Meier curves were applied for the comparison of bond strength among the 3 groups. Results: The mean± standard deviation (SD) bond strength was 13.6±5.33 MPa for Single Bond 2, 13.85±5.86 MPa for Clearfil SE and 12.28±5.24 MPa for Single Bond Universal. The differences in bond strength among the 3 groups were not statistically significant (P>0.05). Conclusion: All three bonding agents are recommended for use with composite posts in PAT. However, due to high technical sensitivity of the Total Etch system, single or two-step self etch systems may be preferred for uncooperative children. PMID:26056518

  19. Observation of Very High-order Electron-radiation Coupling in a 7^th Harmonic IFEL Experiment

    NASA Astrophysics Data System (ADS)

    Tochitsky, Sergei; Williams, Oliver; Musumeci, Pietro; Sung, Chieh; Haberberger, Daniel; Cook, Alan; Rosenzweig, James; Joshi, Chan

    2009-11-01

    FEL/IFELs based on the resonant interaction between laser and electron beams in an undulator would benefit from using efficient high-order resonances. The high-order harmonic FEL/IFEL interactions were considered theoretically as a technique for reduction of the beam energy without corresponding decrease in the undulator period and the magnetic field strength in a single-pass X-ray FEL. We demonstrate microbunching of the 12.3 MeV electrons in a 7^th order IFEL interaction, where the seed radiation frequency is seven times higher then the undulator's fundamental frequency. Strong longitudinal modulation of the beam is inferred from the observation of the first, second and third harmonics of the seed radiation in a Coherent Transition Radiation spectrum. The highest CTR frequency is the 21^st harmonic of the fundamental interaction. The level of seed power is comparable to that required for microbunching at the fundamental frequency in this undulator. This work was supported by DOE grant DE-FG03-92ER40727.

  20. Harmonization of description and classification of fetal observations: achievements and problems still unresolved: report of the 7th Workshop on the Terminology in Developmental Toxicology Berlin, 4-6 May 2011.

    PubMed

    Solecki, Roland; Barbellion, Stephane; Bergmann, Brigitte; Bürgin, Heinrich; Buschmann, Jochen; Clark, Ruth; Comotto, Laura; Fuchs, Antje; Faqi, Ali Said; Gerspach, Ralph; Grote, Konstanze; Hakansson, Helen; Heinrich, Verena; Heinrich-Hirsch, Barbara; Hofmann, Thomas; Hübel, Ulrich; Inazaki, Thelma Helena; Khalil, Samia; Knudsen, Thomas B; Kudicke, Sabine; Lingk, Wolfgang; Makris, Susan; Müller, Simone; Paumgartten, Francisco; Pfeil, Rudolf; Rama, Elkiane Macedo; Schneider, Steffen; Shiota, Kohei; Tamborini, Eva; Tegelenbosch, Mariska; Ulbrich, Beate; van Duijnhoven, E A J; Wise, David; Chahoud, Ibrahim

    2013-01-01

    This article summarizes the 7th Workshop on the Terminology in Developmental Toxicology held in Berlin, May 4-6, 2011. The series of Berlin Workshops has been mainly concerned with the harmonization of terminology and classification of fetal anomalies in developmental toxicity studies. The main topics of the 7th Workshop were knowledge on the fate of anomalies after birth, use of Version 2 terminology for maternal-fetal observations and non-routinely used species, reclassification of "grey zone" anomalies and categorization of fetal observations for human health risk assessment. The paucity of data on health consequences of the postnatal permanence of fetal anomalies is relevant and further studies are needed. The Version 2 terminology is an important step forward and the terms listed in this glossary are considered also to be appropriate for most observations in non-routinely used species. Continuation of the Berlin Workshops was recommended. Topics suggested for the next Workshop were grouping of fetal observations for reporting and statistical analysis.

  1. Humans Transforming the Water Cycle: Implications for Society and Nature over a Multi-Century Timeframe through Synthesis Studies (Invited)

    NASA Astrophysics Data System (ADS)

    Vorosmarty, C. J.; Hermans, C. M.; Green, M.; Pastore, C. L.; Arrigo, J. S.; Parolari, A.

    2010-12-01

    Fresh water is widely regarded as a fundamental, and arguably the most essential, natural resource, supporting a broad array of societal benefits that include basic provisioning services for domestic water supply, the food and energy sectors, commerce, cultural, recreational, and aesthetic values. Water is also critical to the maintenance of ecosystem services and biodiversity. Recent analysis of the global water system using a high resolution geospatial approach demonstrates that a wide array of stressors combine to produce a pattern of worldwide threat to much of the fresh water resource base that sustains human water supply and that is essential to maintaining aquatic biodiversity. A pervasive, globally-significant pattern of management is evident in the contemporary setting, through which impairment accumulates as a function of wealth, but is then remedied by costly technological investments. This strategy of treating symptoms while leaving unabated the underlying causes is practiced widely across rich countries but strands poor nations and much of the world's aquatic biodiversity in a high level of vulnerability. Through research organized under the Northeast Regional Consortium for Hydrologic Synthesis, we are studying a region of the U.S. that serves as an ideal example of the major changes that have taken place with respect to the hydrologic cycle over national and indeed global scales. Using a combination of biogeophysical, social science, and historical scholarship techniques --including the development of a prototype Digital History-- we address an interdisciplinary synthesis goal, that is: To quantify the widespread alteration of hydrologic systems over local-to-regional domains focusing on the Northeast Corridor of the United States over a 500-yr period (1600 to 2100)—The 500-Year Challenge. Pursuing this centuries-scale analysis allows us to gain insight into how water management strategies first became established and ultimately entrenched in the

  2. The Effect of Learning Geometry Topics of 7th Grade in Primary Education with Dynamic Geometer's Sketchpad Geometry Software to Success and Retention

    ERIC Educational Resources Information Center

    Kesan, Cenk; Caliskan, Sevdane

    2013-01-01

    The aim of this study is to investigate the effect of learning geometry topics of 7th grade in primary education with dynamic geometer's sketchpad geometry software to student's success and retention. The experimental research design with The Posttest-Only Control Group was used in this study. In the experimental group, dynamic geometer's…

  3. Assessing the Development of Environmental Virtue in 7th and 8th Grade Students in an Expeditionary Learning Outward Bound School

    ERIC Educational Resources Information Center

    Martin, Bruce; Bright, Alan; Cafaro, Philip; Mittelstaedt, Robin; Bruyere, Brett

    2009-01-01

    This study attempted to assess the development of environmental virtue in 7th and 8th grade students in an Expeditionary Learning Outward Bound (ELOB) school using an instrument developed for this study--the Children's Environmental Virtue Scale (CEVS). Data for this study were obtained by administering the CEVS survey (pretest and posttest) to…

  4. Investigation of Change in Adolescent Perceptions of Mothers' and Fathers' Contributions to Interparental Discord from 7th to 9th Grades

    ERIC Educational Resources Information Center

    Parra, Gilbert R.; Jobe-Shields, Lisa; Kitzmann, Katherine M.; Luebbe, Aaron M.; Olsen, James P.; Davis, Genevieve L.

    2011-01-01

    The purpose of the present study was to examine whether adolescent perceptions of mothers' and fathers' contributions to interparental discord changed from early to middle adolescence and if the changes were related to adolescent negative mood. Data were drawn from the National Longitudinal Survey of Youth 1997. Adolescents who were in 7th grade…

  5. E-Learn 2002 World Conference on E-Learning in Corporate, Government, Healthcare, & Higher Education. Proceedings (7th, Montreal, Quebec, Canada, October 15-19, 2002).

    ERIC Educational Resources Information Center

    Driscoll, Margaret, Ed.; Reeves, Thomas C., Ed.

    The 7th annual E-Learn world conference on e-learning in corporate, government, healthcare, and higher education organized by the Association for the Advancement of Computing in Education (AACE) includes more than 600 papers. Papers from this proceedings come from contributors representing more than 50 countries, sharing their perspectives and…

  6. Studying the Ability of 7th Grade Students to Define the Circle and Its Elements in the Context of Mathematical Language

    ERIC Educational Resources Information Center

    Akarsu, Esra; Yilmaz, Süha

    2015-01-01

    In this study, it was aimed to study the mathematical language skills that the 7th grade students use in defining the circle and its elements. In the study, the mathematical language skills of students that they use in defining the circle and its elements in a scenario were compared to the mathematical language skills they use in defining them…

  7. Use of Jigsaw Technique to Teach the Unit "Science within Time" in Secondary 7th Grade Social Sciences Course and Students' Views on This Technique

    ERIC Educational Resources Information Center

    Yapici, Hakki

    2016-01-01

    The aim of this study is to apply the jigsaw technique in Social Sciences teaching and to unroll the effects of this technique on learning. The unit "Science within Time" in the secondary 7th grade Social Sciences text book was chosen for the research. It is aimed to compare the jigsaw technique with the traditional teaching method in…

  8. Research Examination of the Options to Increase the Education Effectiveness in the Technical Subjects at the 7th Grade of Elementary School Using Hypertext Educational Material

    ERIC Educational Resources Information Center

    Žácok, L'ubomir

    2010-01-01

    The utilization of hypertext educational material is going to be solved in this paper as a source using which the effectiveness of education the technical subjects at the 7th grade of elementary school can be increased. As a comparison between reached results in the control and experimental groups of pupils we used final didactical examination,…

  9. Determining the Effects of Using Different Writing Activities on the Academic Achievements Secondary School 7th Grade Students and Their Attitudes Towards the Course

    ERIC Educational Resources Information Center

    Uzoglu, Mustafa

    2014-01-01

    The purpose of the study is to determine the effects of using writing activities with different learning purposes by the secondary school 7th grade students on their academic achievement and attitudes towards the course. The study was carried out in a secondary school located in the centre of Erzurum in 2012-2013 academic year; the study is a…

  10. The Effects of Learning Activities Based on Argumentation on Conceptual Understanding of 7th Graders about "Force and Motion" Unit and Establishing Thinking Friendly Classroom Environment

    ERIC Educational Resources Information Center

    Buber, Ayse; Coban, Gul Unal

    2017-01-01

    The purpose of this study was to investigate the effects of learning activities based on argumentation about "Force and Motion" unit on conceptual understanding and views about establishing thinking friendly classroom environment of 7th graders. The study was conducted with total 39 students (20 students in experimental group and 19…

  11. Influence of Skip Patterns on Item Non-Response in a Substance Use Survey of 7th to 12th Grade Students

    ERIC Educational Resources Information Center

    Ding, Kele; Olds, R. Scott; Thombs, Dennis L.

    2009-01-01

    This retrospective case study assessed the influence of item non-response error on subsequent response to questionnaire items assessing adolescent alcohol and marijuana use. Post-hoc analyses were conducted on survey results obtained from 4,371 7th to 12th grade students in Ohio in 2005. A skip pattern design in a conventional questionnaire…

  12. The Impact of Project-Based Learning on Mathematics and Reading Achievement of 7th and 8th Grade Students in a South Texas School District

    ERIC Educational Resources Information Center

    Cervantes, Bernadine Munoz

    2013-01-01

    The study examined the impact of Project-Based Learning on reading and mathematics achievement of 7th and 8th grade students. Project-based learning deviates from the customary school practices and is an innovative strategy used in the curriculum to engage students in solving authentic problems for deeper learning experiences. The association…

  13. Making the Grade: Do Nebraska Teachers and Administrators Working in Public Schools in 7th-12th Grade Settings Agree about What Constitutes Sound Grading Practice?

    ERIC Educational Resources Information Center

    Olson, Mark E.

    2013-01-01

    In this study, the researcher sought to determine whether Nebraska teachers and administrators agreed about what constitutes sound grading practice. The results of this study indicated that Nebraska teachers and administrators working in public schools in 7th-12th grade settings did not always agree about what constituted sound grading practice.…

  14. Influence of Skip Patterns on Item Non-Response in a Substance Use Survey of 7th to 12th Grade Students

    ERIC Educational Resources Information Center

    Ding, Kele; Olds, R. Scott; Thombs, Dennis L.

    2009-01-01

    This retrospective case study assessed the influence of item non-response error on subsequent response to questionnaire items assessing adolescent alcohol and marijuana use. Post-hoc analyses were conducted on survey results obtained from 4,371 7th to 12th grade students in Ohio in 2005. A skip pattern design in a conventional questionnaire…

  15. Making the Grade: Do Nebraska Teachers and Administrators Working in Public Schools in 7th-12th Grade Settings Agree about What Constitutes Sound Grading Practice?

    ERIC Educational Resources Information Center

    Olson, Mark E.

    2013-01-01

    In this study, the researcher sought to determine whether Nebraska teachers and administrators agreed about what constitutes sound grading practice. The results of this study indicated that Nebraska teachers and administrators working in public schools in 7th-12th grade settings did not always agree about what constituted sound grading practice.…

  16. Determining the Effects of Using Different Writing Activities on the Academic Achievements Secondary School 7th Grade Students and Their Attitudes Towards the Course

    ERIC Educational Resources Information Center

    Uzoglu, Mustafa

    2014-01-01

    The purpose of the study is to determine the effects of using writing activities with different learning purposes by the secondary school 7th grade students on their academic achievement and attitudes towards the course. The study was carried out in a secondary school located in the centre of Erzurum in 2012-2013 academic year; the study is a…

  17. Balancing acts: A mixed methods study of the figured world of African American 7th graders in urban science classrooms

    NASA Astrophysics Data System (ADS)

    Cleveland-Solomon, Tanya E.

    What beliefs and cultural models do youth who are underrepresented in science have about the domain of science and about themselves as science learners? What do they imagine is possible for them in relation to science both now and in the future? In other words, what constitutes their figured world of science? This dissertation study, using a mixed methods design, offers new perspectives on the ways that underrepresented youth's unexamined assumptions or cultural models and resources may shape their identities and motivation to learn science. Through analyses of survey and interview data, I found that urban African American youths' social context, gender, racial identity, and perceptions of the science they had in school influenced their motivation to learn science. Analyses of short-term classroom observations and interviews suggested that students had competing cultural models that they used in their constructions of identities as science learners, which they espoused and adopted in relation to how well they leveraged the science-related cultural resources available to them. Results from this study suggested that these 7th graders would benefit from access to more expansive cultural models through access to individuals with scientific capital as a way to allow them to create fruitful identities as science learners. If we want to ensure that students from groups that are underrepresented in science not only have better outcomes, but aspire to and enter the science career pipeline, we must also begin to support them in their negotiations of competing cultural models that limit their ability to adopt science-learner identities in their classrooms. This study endeavored to understand the particular cultural models and motivational beliefs that drive students to act, and what types of individuals they imagine scientists and science workers to be. This study also examined how cultural models and resources influence identity negotiation, specifically the roles youths

  18. Can we improve breast cancer mortality in Okinawa? Consensus of the 7th Okinawa Breast Oncology Meeting.

    PubMed

    Tamaki, Kentaro; Tamaki, Nobumitsu; Kamada, Yoshihiko; Uehara, Kano; Zaha, Hisamitsu; Onomura, Mai; Ueda, Makoto; Kurashita, Kaname; Miyazato, Keiko; Higa, Junko; Miyara, Kyuichiro; Shiraishi, Makiko; Murayama, Shigemi; Ishida, Takanori

    2015-01-01

    The rate of breast cancer mortality in Okinawa has gradually been increasing up to 2010. Now Okinawa has the second worst mortality rate in Japan, in part due to the enormous dietary changes resulting from the post-World War II US military occupation, high incidence of obesity, high non-optimal treatment rate, and low breast-cancer screening rate. To reduce breast cancer mortality in Okinawa, we established the Okinawa Breast Oncology Meeting (OBOM) in 2012. At the 7th OBOM held on January 10th, 2014, we discussed the breast cancer mortality in Okinawa focusing on lifestyle, breast cancer screening and optimal treatments. The Okinawan women who were overweight and/or obese during premenopausal and postmenopausal ages had a statistically significant higher risk of breast cancer development compared to those with non-overweight and/or obese women. The traditional diet of Okinawa consists of foods low in calories but rich in nutritional value. Therefore, we recommend Okinawan people not to forget the Okinawan traditional lifestyle, and to reduce their bodyweight to prevent breast cancer. One of the main goals of the OBOM is to raise breast cancer screening attendance rates to 50% (29.2% in 2010). We should standardize the quality control for breast cancer screening in Okinawa. It is important to continue enlightening the Okinawan population to receive optimal treatment. In addition, we are striving to establish systematic medical cooperation between the hospitals specializing in breast cancer treatment with rural hospitals. The OBOM group endeavors to contribute to the improvement of breast cancer mortality in Okinawa.

  19. PREFACE: EUCAS '05: The 7th European Conference on Applied Superconductivity (Vienna University of Technology, Austria, 11 15 September 2005)

    NASA Astrophysics Data System (ADS)

    Donaldson, Gordon; Weber, Harald W.; Sauerzopf, Franz M.

    2006-03-01

    This issue of Superconductor Science and Technology contains the plenary and invited papers presented at the 7th European Conference on Applied Superconductivity (EUCAS '05) that was held at the Vienna University of Technology from 11-15 September 2005. All those contributed papers that were submitted to the Conference Proceedings will be published in the Journal of Physics: Conference Series. The scientific aims of EUCAS '05 followed the tradition established at the preceding conferences in Göttingen, Edinburgh, Eindhoven, Sitges (Barcelona), Lyngby (Copenhagen) and finally Sorrento (Napoli). The focus was placed on the interplay between the most recent developments in superconductor research and the positioning of applications of superconductivity in the marketplace. Although initially founded as an exchange forum mainly for European scientists, it has gradually developed into a truly international meeting with significant attendance from the Far East and the United States. The Vienna conference attracted 813 participants in the scientific programme and 90 accompanying persons. 59% of all participants came from Europe, 31% from the Far East, 6% from the United States and Canada as well as 4% from other nations worldwide. 27 companies presented their latest developments in the field. 32 plenary and invited lectures highlighted the state-of-the-art in the areas of materials, large-scale as well as small-scale applications; 625 contributed papers (among them 556 posters) demonstrated the broad range of exciting activities in all research areas of our field. EUCAS '05 spread a lot of optimism and enthusiasm for this fascinating field of research and for its well established technological potential, especially among the numerous young researchers attending this conference. We are grateful to all those who participated in the meeting and contributed to its success.

  20. Validation of the 7th TNM classification for non-small cell lung cancer: a retrospective analysis on prognostic implications for operated node-negative cases.

    PubMed

    Bergman, Per; Brodin, Daniel; Lewensohn, Rolf; de Petris, Luigi

    2013-08-01

    The 7th TNM staging system for non-small cell lung cancer (NSCLC) developed by the International Association for the study of Lung Cancer (IASLC) has been applied in Sweden since the beginning of the year 2010. The aim of this retrospective study was to evaluate the prognostic role of the 7th TNM staging system in a surgical Swedish patient cohort with node-negative NSCLC. We collected data from stage I patients (pT1-2 pN0, 6th TNM system) who underwent surgery for NSCLC at Karolinska University Hospital from 1987 to 2002. Tumors were restaged according to the 7th TNM version. Cox multivariate survival analysis was implemented in order to determine the prognostic impact of pathological stage when classified according to either the 6th or the 7th TNM systems. The patient population consisted of 452 subjects. Tumor size was ≤ 3 cm in 51% of cases. The predominant histology was adenocarcinoma (53%) and lobectomy was the most common surgical procedure (82% of patients). The five-year survival rate in patients with stage IA vs. IB (6th TNM) was 62% vs. 51%, respectively (log-rank p = 0.036). Corresponding figures for the 7th TNM system were 70% in stage IA-T1a, 51% in stage IA-T1b, 54% in stage IB, 51% in stage IIA and 35% in stage IIB (log-rank p = 0.002). On multivariate analysis, adjusted by age, gender, histology, kind of surgery, grade of differentiation and smoking status, pathological stage was an independent prognostic factor if classified according to the 7th TNM version (p = 0.001), but not if scored according to the 6th TNM edition (p = 0.090). The 7th TNM classification system is a more accurate predictor of prognosis in stage I operated patients than the old classification. The new system should be implemented even on retrospective cohorts especially when investigating the prognostic implication of the expression of molecular biomarkers.

  1. Prognostic value of the 7th AJCC/UICC TNM classification of noncardia gastric cancer: analysis of a large series from specialized Western centers.

    PubMed

    Marrelli, Daniele; Morgagni, Paolo; de Manzoni, Giovanni; Coniglio, Arianna; Marchet, Alberto; Saragoni, Luca; Tiberio, Guido; Roviello, Franco

    2012-03-01

    To conduct a retrospective evaluation of the 7th-TNM classification of gastric cancer (GC) on a prospectively collected database. The recent TNM introduced relevant changes to GC classification. Data regarding 2090 consecutive patients with noncardia GC operated upon between 1991 and 2005 at 5 specialized centers were considered. The application of the new TNM was simulated, and its prognostic value was estimated. Relevant changes in stage distribution between 6th and 7th TNM were observed, mainly regarding the shift of a large proportion of cases from stages IB to IIA and from IIIA and IV to stages IIIB and IIIC. Cancer-related 10-year survival probability was 53% ± 1%. Different survival rates between new T (T2 vs. T3, P < 0.001) and N categories (N1 vs. N2, P < 0.001) were observed. Survival rate of N3a subgroup (7-15 involved lymph nodes) was significantly better than N3b (>15 involved lymph nodes; P < 0.001). Stages IB and IIA of the 7th TNM showed similar prognosis, whereas significant differences were observed among all other subgroups. The analysis of TNM categories within 7th TNM stages revealed nonhomogeneous survival rates in stages IIB, IIIB, and IV. The 7th AJCC/UICC TNM classification of noncardia GC identifies subgroups of patients with different prognosis. Stage distribution and stage-related survival changed notably from the 6th edition. Some improvements may be suggested from our data, with special reference to a higher prognostic weight of N status and the separation of N3a and N3b categories for stage grouping.

  2. 7th U.S. / Japan Natural Resources (UJNR) Panel on Earthquake Research: Abstract Volume and Technical Program

    USGS Publications Warehouse

    Detweiler, Shane T.; Ellsworth, William L.

    2008-01-01

    making information public in a timely manner. The Panel visited sites along the east coast of Shikoku that were inundated by the tsunami caused by the 1946 Nankai earthquake where they heard from survivors of the disaster and saw new tsunami shelters and barriers. They also visited the Median Tectonic Line, a major onshore strike-slip fault on Shikoku. The 7th Joint Panel meeting was held in Seattle, Wash., U.S.A. from October 27-30, 2008.

  3. Human teeth as historical biomonitors of environmental and dietary lead: some lessons from isotopic studies of 19th and 20th century archival material.

    PubMed

    Farmer, J G; MacKenzie, A B; Moody, G H

    2006-10-01

    The lead isotopic composition of various sections (crown, crown base, root) of teeth was determined in specimens collected from 19th century skulls preserved in museum collections and, upon extraction or exfoliation, from humans of known ages residing in Scotland in the 1990s. For most 20th century samples, calculation of accurate crown-complete or root-complete dates of tooth formation ranging from the 1920s to the 1990s enabled comparison of (206)Pb/(207)Pb ratios for teeth sections (crown base root) with corresponding decadally averaged data for archival herbarium Sphagnum moss samples. This showed that the teeth sections had been significantly influenced by incorporation of non-contemporaneous (more recent) lead subsequent to the time of tooth formation, most probably via continuous uptake by dentine. This finding confirmed that separation of enamel from dentine is necessary for the potential of teeth sections as historical biomonitors of environmental (and dietary) lead exposure at the time of tooth formation to be realised. Nevertheless, the mean 19th century value of 1.172+/-0.007 for the (206)Pb/(207)Pb ratio in teeth was very similar to the corresponding mean value of 1.173+/-0.004 for 19th century archival moss, although relative contributions from environmental sources - whether direct, by inhalation/ingestion of dust contaminated by local lead smelting ((206)Pb/(207)Pb~1.17) and coal combustion ((206)Pb/(207)Pb~1.18) emissions, or indirect, through ingestion of similarly contaminated food - and drinking/cooking water contaminated by lead pipes of local origin, cannot readily be determined. In the 20th century, however, the much lower values of the (206)Pb/(207)Pb ratio (range 1.100-1.166, mean 1.126+/-0.013, median 1.124) for the teeth collected from various age groups in the 1990s reflect the significant influence of imported Australian lead of lower (206)Pb/(207)Pb ratio (~1.04) and released to the environment most notably through car

  4. The Effect of Computer Assisted Instruction on the Achievement of Students on the Instruction of Physics Topic of 7th Grade Science Course at a Primary School

    NASA Astrophysics Data System (ADS)

    Kara, Izzet; Kahraman, Ozkan

    The aim of this study is to determine the effect of Computer Assisted Instruction on the academic achievement of the students on the instruction of Physics subjects of 7th grade science lesson. This study includes Force and Pressure topics of 7th grade Science lesson. Two hundred and fifty three students joined in this study as control and experiment groups. Control group took only traditional instruction; experiment group took traditional instruction supported by teacher controlled computer assisted instruction. For both groups, Science subject test was applied as a pre-test before the instruction. It was seen a difference between the control and experiment groups` average scores at Science subject test at a significant level.

  5. Climate and human intervention effects on future fire activity and consequences for air pollution across the 21st century

    NASA Astrophysics Data System (ADS)

    Val Martin, M.; Pierce, J. R.; Heald, C. L.; Li, F.; Lawrence, D. M.; Wiedinmyer, C.; Tilmes, S.; Vitt, F.

    2016-12-01

    Emissions of aerosols and gases from fires have been shown to adversely affect air quality across the world. Fire activity is strongly related to climate and anthropogenic activities. Current fire projections for the 21st century seem very uncertain, ranging from increasing to declining depending on the climate, land cover change and population growth scenarios used. Here we present an analysis of the changes in future wildfire activity and consequences on air quality, with focus on PM2.5 and surface O3 over regions vulnerable to fire. We use the global Community Earth System Model (CESM) with a process-based fire model to simulate emissions from agriculture, peatland, deforestation and landscape fires for present-day and throughout the current century. We consider two future Representative Concentration Pathways climate scenarios combined with population density changes predicted from Shared Socio-economic Pathways to project climate and demographic effects on fire activity and further consequences for future air quality.

  6. High Performance Proteomics: 7th HUPO Brain Proteome Project Workshop March 7-9, 2007 Wellcome Trust Conference Centre, Hinxton, UK.

    PubMed

    Hamacher, Michael; Stephan, Christian; Eisenacher, Martin; Lewczuk, Piotr; Wiltfang, Jens; Martens, Lennart; Vizcaíno, Juan Antonio; Kwon, Kyung-Hoon; Yoo, Jong Shin; Park, Young Mok; Beckers, Johannes; Horsch, Marion; de Angelis, Martin Hrabé; Cho, Zang-Hee; Apweiler, Rolf; Meyer, Helmut E

    2007-08-01

    The Wellcome Trust Conference Centre at Hinxton, UK, was the meeting place of the 7th HUPO Brain Proteome Project Workshop entitled "High Performance Proteomics". It started on Wednesday, March 7, 2007 with a steering committee meeting followed by a two days series of talks dealing with the standardization and handling of tissues, body fluids as well as of proteomics data. The presentation and accompanying vivid discussions created a picture of actual strategies and standards in recent proteomics.

  7. 7th EFIS Tatra Immunology Conference. Molecular determinants of T-cell immunity. 24-28 June 2006, High Tatra Mountains, Slovakia.

    PubMed

    Leishman, Andrew J

    2006-10-01

    This meeting was hosted by the European Federation of Immunological Societies celebrating its 7th meeting in the High Tatra Mountains of Slovakia on 24-28 June 2006. Entitled molecular determinants of T-cell immunity, the meeting covered a wide range of novel methods to regulate an unwanted immune response in autoimmunity and boost the immune system to combat viral infection and cancer.

  8. [First results of participation of the Czech Republic in the 7th Framework Programme, priority Health, in years 2007-2013].

    PubMed

    Kinkorová, Judita

    2013-01-01

    European Commission has announced the first preliminary results of participation in the 7th Framework Programme (FP7), priority Health. The overview presents the basic statistics regarding the participation of the Czech teams, universities, institutions, and small and medium size enterprises (SMEs) in FP7 projects. The aim of the article is to present the basic data on the projects with the Czech participation, the EU financial contribution for Czech teams and the main research topics.

  9. 7th International Conference on Excitonic Processes in Condensed Matter (EXCON'06) Winston-Salem, NC, USA, 26-30 June 2006

    NASA Astrophysics Data System (ADS)

    Petelenz, P.; Schreiber, M.

    2006-10-01

    This conference report is meant to offer an authoritative view on a recently held scientific meeting rather than a comprehensive list of the conference presentations. We tried to describe what we feel were the most interesting contributions.The full Proceedings of the 7th International Conference on Excitonic Processes in Condensed Matter (EXCON'06) shall be published in phys. stat. sol. (b) and phys. stat. sol. (c) in November 2006.

  10. A century-scale, human-induced ecohydrological evolution of wetlands of two large river basins in Australia (Murray) and China (Yangtze)

    NASA Astrophysics Data System (ADS)

    Kattel, Giri R.; Dong, Xuhui; Yang, Xiangdong

    2016-06-01

    Recently, the provision of food and water resources of two of the world's largest river basins, the Murray and the Yangtze, has been significantly altered through widespread landscape modification. Long-term sedimentary archives, dating back for some centuries from wetlands of these river basins, reveal that rapid, basin-wide development has reduced the resilience of biological communities, resulting in considerable decline in ecosystem services, including water quality. Large-scale human disturbance to river systems, due to river regulation during the mid-20th century, has transformed the hydrology of rivers and wetlands, causing widespread modification of aquatic biological communities. Changes to cladoceran zooplankton (water fleas) were used to assess the historical hydrology and ecology of three Murray and Yangtze river wetlands over the past century. Subfossil assemblages of cladocerans retrieved from sediment cores (94, 45, and 65 cm) of three wetlands: Kings Billabong (Murray), Zhangdu, and Liangzi lakes (Yangtze), showed strong responses to hydrological changes in the river after the mid-20th century. In particular, river regulation caused by construction of dams and weirs together with river channel modifications, has led to significant hydrological alterations. These hydrological disturbances were either (1) a prolonged inundation of wetlands or (2) reduced river flow, both of which caused variability in wetland depth. Inevitably, these phenomena have subsequently transformed the natural wetland habitats, leading to a switch in cladoceran assemblages to species preferring poor water quality, and in some cases to eutrophication. The quantitative and qualitative decline of wetland water conditions is indicative of reduced ecosystem services, and requires effective restoration measures for both river basins which have been impacted by recent socioeconomic development and climate change.

  11. PREFACE: NC-AFM 2004: Proceedings of the 7th International Conference on Non-contact Atomic Force Microscopy

    NASA Astrophysics Data System (ADS)

    Schwarz, Udo

    2005-03-01

    With the ongoing miniaturization of devices and controlled nanostructuring of materials, the importance of atomic-scale information on surfaces and surface properties is growing continuously. The astonishing progress in nanoscience and nanotechnology that took place during the last two decades was in many ways related to recent progress in high-resolution imaging techniques such as scanning tunnelling microscopy and transmission electron microscopy. Since the mid-1990s, non-contact atomic force microscopy (NC-AFM) performed in ultrahigh vacuum has evolved as an alternative technique that achieves atomic resolution, but without the restriction to conducting surfaces of the previously established techniques. Advances of the rapidly developing field of NC-AFM are discussed at annual conferences as part of a series that started in 1998 in Osaka, Japan. This special issue of Nanotechnology is a compilation of original work presented at the 7th International Conference on Non-contact Atomic Force Microscopy that took place in Seattle, USA, 12-15 September 2004. Over the years, the conference grew in size and scope. Atomic resolution imaging of oxides and semiconductors remains an issue. Noticeable new developments have been presented in this regard such as, e.g., the demonstrated ability to manipulate individual atoms. Additionally, the investigation of individual molecules, clusters, and organic materials gains more and more attention. In this context, considerable effort is undertaken to transfer the NC-AFM principle based on frequency modulation to applications in air and liquids with the goal of enabling high-resolution surface studies of biological material in native environments, as well as to reduce the experimental complexity, which so far involves the availability of (costly) vacuum systems. Force spectroscopy methods continue to be improved and are applied to topics such as the imaging of the three-dimensional force field as a function of the distance with

  12. Selected papers from the 7th International Conference on Biomimetics, Artificial Muscles and Nano-bio (BAMN2013)

    NASA Astrophysics Data System (ADS)

    Shahinpoor, Mohsen; Oh, Ilkwon

    2014-07-01

    The 7th International Congress on Biomimetics, Artificial Muscles and Nano-Bio was held on the magnificent and beautiful Jeju Island in Korea on 26-30 August 2013. In June 2007, the volcanic island and lava tube cave systems were designated as UNESCO World Natural Heritage Sites for their natural beauty and unique geographical values. The aim of the congress was to offer high-level lectures, extensive discussions and communications covering the state-of-the-art on biomimetics, artificial muscles, and nano-bio technologies providing an overview of their potential applications in the industrial, biomedical, scientific and robotic fields. This conference provided a necessary platform for an ongoing dialogue between researchers from different areas (chemistry, physics, biology, medicine, engineering, robotics, etc) within biomimetics, artificial muscle and nano-bio technologies. This special issue of Smart Materials and Structures is devoted to a selected number of research papers that were presented at BAMN2013. Of the 400 or so papers and over 220 posters presented at this international congress, 15 papers were finally received, reviewed and accepted for this special issue, following the regular peer review procedures of the journal. The special issue covers polymeric artificial muscles, electroactive polymers, multifunctional nanocomposites, and their applications. In particular, electromechanical performance and other characteristics of ionic polymer-metal composites (IPMCs) fabricated with various commercially available ion exchange membranes are discussed. Additionally, the control of free-edge interlaminar stresses in composite laminates using piezoelectric actuators is elaborated on. Further, the electrode effects of a cellulose-based electroactive paper energy harvester are described. Next, a flexible tactile-feedback touch screen using transparent ferroelectric polymer film vibrators is discussed. A broad coverage of bio-applications of IPMC transducers is

  13. Metastatic lymph node ratio, 6th or 7th AJCC edition: witch is the best lymph node classification for esophageal cancer? Prognosis factor analysis in 487 patients

    PubMed Central

    CORAL, Roberto V.; BIGOLIN, André V.; CORAL, Roberto P.; HARTMANN, Antonio; DRANKA, Carolina; ROEHE, Adriana V.

    2015-01-01

    Background The esophageal cancer is one of the most common and aggressive worldwide. Recently, the AJCC changed the staging system, considering, among others, the important role of the lymph node metastasis on the prognosis. Aim To discuss the applicability of different forms of lymph node staging in a western surgical center. Methods Four hundred eighty seven patients with esophageal cancer were enrolled. Three staging systems were evaluated, the 6th and the 7th AJCC editions and the Lymph Node Metastatic Ratio. Results The majority of the cases were squamous cell carcinoma. The mean lymph node sample was eight. Considering the survival, there was no significant difference between the patients when they were classified by the 7th AJCC edition. Analysis of the Lymph Node Metastatic Ratio, just on the group of patients with 0 to 25%, has shown significant difference (p=0,01). The 6th AJCC edition shows the major significant difference between among the classifications evaluated. Conclusion In this specific population, the 7th AJCC edition for esophageal cancer was not able to find differences in survival when just the lymph node analysis was considered. PMID:26176242

  14. Changing Configurations of Adult Education in Transitional Times. Conference Proceedings of the Triennial European Research Conference of the European Society for Research on the Education of Adults (ESREA) (7th, Berlin, Germany, September 4-7, 2013)

    ERIC Educational Resources Information Center

    Käpplinger, Bernd, Ed.; Lichte, Nina, Ed.; Haberzeth, Erik, Ed.; Kulmus, Claudia, Ed.

    2014-01-01

    This book assembles over 50 papers from the 7th Triennial European Research Conference of the European Society for Research on the Education of Adults (ESREA), which was held from the 4th to the 7th of September 2013 at Humboldt-University in Berlin. The title of the conference was "Changing Configurations of Adult Education in Transitional…

  15. Historical stocking data and 19th century DNA reveal human-induced changes to native diversity and distribution of cutthroat trout.

    PubMed

    Metcalf, J L; Love Stowell, S; Kennedy, C M; Rogers, K B; McDonald, D; Epp, J; Keepers, K; Cooper, A; Austin, J J; Martin, A P

    2012-11-01

    Many species are threatened with extinction and efforts are underway worldwide to restore imperilled species to their native ranges. Restoration requires knowledge of species' historical diversity and distribution. For some species, many populations were extirpated or individuals moved beyond their native range before native diversity and distribution were documented, resulting in a lack of accurate information for establishing restoration goals. Moreover, traditional taxonomic assessments often failed to accurately capture phylogenetic diversity. We illustrate a general approach for estimating regional native diversity and distribution for cutthroat trout in the Southern Rocky Mountains. We assembled a large archive of historical records documenting human-mediated change in the distribution of cutthroat trout (Oncorhynchus clarkii) and combined these data with phylogenetic analysis of 19th century samples from museums collected prior to trout stocking activities and contemporary DNA samples. Our study of the trout in the Southern Rocky Mountains uncovered six divergent lineages, two of which went extinct, probably in the early 20th century. A third lineage, previously declared extinct, was discovered surviving in a single stream outside of its native range. Comparison of the historical and modern distributions with stocking records revealed that the current distribution of trout largely reflects intensive stocking early in the late 19th and early 20th century from two phylogenetically and geographically distinct sources. Our documentation of recent extinctions, undescribed lineages, errors in taxonomy and dramatic range changes induced by human movement of fish underscores the importance of the historical record when developing and implementing conservation plans for threatened and endangered species.

  16. Intersection of economics, history, and human biology: secular trends in stature in nineteenth-century Sioux Indians.

    PubMed

    Prince, J M

    1995-06-01

    An unusual confluence of historical factors may be responsible for nineteenth-century Sioux being able to sustain high statures despite enduring adverse conditions during the early reservation experience. An exceptionally long span of Dakota Sioux history was examined for secular trends using a cross-sectional design. Two primary sources were used: One anthropometric data set was collected in the late nineteenth century under the direction of Franz Boas, and another set was collected by James R. Walker in the early twentieth century. Collectively, the data represent the birth years between 1820 and 1880 for adult individuals 20 years old or older. Adult heights (n = 1197) were adjusted for aging effects and regressed on age, with each data set and each sex analyzed separately. Tests for differences between the adult means of age cohorts by decade of birth (1820-1880) were also carried out. Only one sample of adults showed any convincing secular trend (p < 0.05): surprisingly, a positive linear trend for Walker's sample of adult males. This sample was also the one sample of adults that showed significant differences between age cohorts. The failure to find any negative secular trend in this population of Amerindians is remarkable, given the drastic socioeconomic changes that occurred with the coming of the reservation period (ca. 1868). Comparisons with contemporary white Americans show that the Sioux remained consistently taller than whites well into the reservation period and that Sioux children (Prince 1989) continued to grow at highly favorable rates during this time of severe conditions. A possible explanation for these findings involves the relatively favorable level of subsistence support received by most of the Sioux from the US government, as stipulated by various treaties. Conservative estimates suggest that the Sioux may have been able to sustain net levels of per capita annual meat consumption that exceeded the US average for several years before 1893.

  17. Perception and description of New World non-human primates in the travel literature of the fifteenth and sixteenth centuries: a critical review.

    PubMed

    Veracini, Cecilia; Teixeira, Dante Martins

    2017-01-01

    The current work presents the results of a review of most of the European diaries and travel chronicles containing reports of New World non-human primates dating from the discovery of America in 1492 until the end of the sixteenth century. We report the integral texts translated into English of these literary sources, giving a critical interpretation from a historical and scientific point of view. We note the ways these primates were perceived and described, with attention to the most important characteristics that were highlighted by the first explorers. Ethnotaxonomy and vernacular names used to designate non-human primates are also provided. This new body of knowledge, based largely on empirical reports full of details and first-hand observations, emerged as the first nucleus in the natural history of Neotropical Primates.

  18. In naming the dead: Autosomal and Y-chromosomal STR typing on human skeletal remains from an 18th/19th century aristocratic crypt in Gallspach, Upper Austria.

    PubMed

    Schwarz, Reinhard; Renhart, Silvia; Gruber, Heinz; Kli Mesch, Wolfgang; Neuhuber, Franz; Cemper-Kiesslich, Jan

    2015-01-01

    Ancient DNA analyses have shown to be a powerful tool in the joint transdisciplinary assessment of archaeological records involving human remains. In this study we set out to identify single inhumations by synoptically evaluating the historical, archaeological, anthropological and molecular records on human remains from the crypt of the aristocratic family of Hoheneck (or: Hohenegg) dating to the 18(th) and 19(th) century AD. A total of 11 individuals were under investigation, yielding complete autosomal and Y-chromosomal STR profiles for 5 persons clearly showing a family group. DNA results, anthropological data and archaeological records taken together resulted in (almost) unambiguous correlation to historical records on the persons entombed in the crypt.

  19. New World Vistas: Air and Space Power for the 21st Century, Human Systems and Biotechnology Volume.

    DTIC Science & Technology

    1996-06-01

    important step in meeting that requirement. 12 5.0 Precision Guided Training4 Assertion By the year 2020, utilizing knowledge of human learner ...Personnel selection and classification systems 2. Cognitive and non-cognitive models of the human learner and of the instructional process 3...of the human learner , to how he/she perceives and organizes information, to valid models of human skill/knowledge acquisition, and to how training can

  20. Russian psychology at the turn of the 21st century and post-Soviet reforms in the humanities disciplines.

    PubMed

    Vassilieva, Julia

    2010-05-01

    The author traces the changes in Russian psychology in the past 25 years and links these changes to the earlier Russian legacy of Lev Vygotsky (1896-1934) and Aleksei N. Leontiev (1903-1979). The move into the 21st century coincided for Russian psychology as well as for the Russian society at large with the reforms of perestroika, leading to greater openness in the academic sphere. In particular, Russian psychology was able to connect in a more free and fundamental way with its own heritage and with various developments around the world. The author discusses how these factors affected continuity and innovation with regard to the 2 dominant theoretical perspectives in Russian psychology--the cultural-historical theory of Vygotsky and the theory of activity, initially developed by Leontiev. The author argues that while there are now original and substantial shifts within Russian psychology--namely toward the new paradigm characterized by various researchers as "organic psychology," "nonclassical psychology," or even "post-non-classical" psychology--the issues of agency and meaning, which were central for the previous generation of Russian psychologists, such as Vygotsky, Leontiev, Luria, Zaporozhets, Rubinstein, and others, continue to inform the development of the discipline in the 21st century.

  1. Response of the global water availability and use model WaterGAP to different climatic forcings and human impacts within the late 20th century

    NASA Astrophysics Data System (ADS)

    Müller Schmied, Hannes; Eisner, Stephanie; Portmann, Felix T.; Fink, Gabriel; Flörke, Martina; Döll, Petra

    2015-04-01

    Global-scale hydrological modeling faces multiple sources of uncertainty resulting from e.g. input data, model structure and model parameters, and it is of particular interest to investigate the sensitivity of a model to these influences. In the last years, a number of climate forcing data sets were developed for the global modelling community, and variable fields were found to differ significantly between the data-sets in certain regions. On the other side, human activity has a significant impact on the global hydrological cycle, e.g. through the construction of dams and the abstraction of water for irrigation purposes. In a global-scale hydrological modelling approach, human impact can be represented in various ways. It can be neglected (i.e. naturalized conditions without human impacts on river flow are simulated), kept at a constant level (e.g. present day conditions), or it can be simulated time-variant hence mimicking historical development of reservoirs and irrigation demand. Both uncertainties (forcing data, human impact) are influencing the response (i.e. output) of a water model, and it is assumed that the sensitivity of model outputs increases when combining the uncertainties of both input data. In this study we applied the WaterGAP global water availability and use model for 12 simulation setups resulting from four climate forcings (PGMFD v.2 (Princeton), GSWP3 (Global Soil Wetness Project 3), WATCH (WATCH Forcing Data, WFD), WATCH+WFD/ERAInterim) and three settings for human impact (naturalized, constant human impacts, time-varying human impacts). We assess the modeled water balance components for the late 20th century and evaluate the relative response to climate forcing as compared to human impact. Results are presented for selected large river basins as well as for the global scale.

  2. Dietary guidelines to nourish humanity and the planet in the twenty-first century. A blueprint from Brazil.

    PubMed

    Monteiro, Carlos Augusto; Cannon, Geoffrey; Moubarac, Jean-Claude; Martins, Ana Paula Bortoletto; Martins, Carla Adriano; Garzillo, Josefa; Canella, Daniela Silva; Baraldi, Larissa Galastri; Barciotte, Maluh; Louzada, Maria Laura da Costa; Levy, Renata Bertazzi; Claro, Rafael Moreira; Jaime, Patrícia Constante

    2015-09-01

    To present and discuss the dietary guidelines issued by the Brazilian government in 2014. The present paper describes the aims of the guidelines, their shaping principles and the approach used in the development of recommendations. The main recommendations are outlined, their significance for the cultural, socio-economic and environmental aspects of sustainability is discussed, and their application to other countries is considered. Brazil in the twenty-first century. All people in Brazil, now and in future. The food- and meal-based Brazilian Dietary Guidelines address dietary patterns as a whole and so are different from nutrient-based guidelines, even those with some recommendations on specific foods or food groups. The guidelines are based on explicit principles. They take mental and emotional well-being into account, as well as physical health and disease prevention. They identify diet as having cultural, socio-economic and environmental as well as biological and behavioural dimensions. They emphasize the benefits of dietary patterns based on a variety of natural or minimally processed foods, mostly plants, and freshly prepared meals eaten in company, for health, well-being and all relevant aspects of sustainability, as well as the multiple negative effects of ready-to-consume ultra-processed food and drink products. The guidelines' recommendations are designed to be sustainable personally, culturally, socially, economically and environmentally, and thus fit to face this century. They are for foods, meals and dietary patterns of types that are already established in Brazil, which can be adapted to suit the climate, terrain and customs of all countries.

  3. Prevalence of amblyopia and strabismus in a population of 7th-grade junior high school students in Central China: the Anyang Childhood Eye Study (ACES).

    PubMed

    Fu, Jing; Li, Shi Ming; Liu, Luo Ru; Li, Jin Ling; Li, Si Yuan; Zhu, Bi Dan; Li, He; Yang, Zhou; Li, Lei; Wang, Ning Li

    2014-06-01

    To determine the prevalence of amblyopia and strabismus in 7th-grade junior high school students in central China. Using stratified cluster sampling, 2363 7th-grade students were recruited from four junior high schools in Anyang city into the cross-sectional Anyang Childhood Eye Study (ACES). All students underwent visual acuity (VA), cycloplegic autorefraction, cover test, and ocular movement examinations. Uncorrected VA and best-corrected VA (BCVA) were measured with a logarithm of the minimum angle of resolution (logMAR) chart. Cycloplegic autorefraction was performed after administration of 1.0% cyclopentolate and Mydrin-P. Strabismus was defined as heterotropia at near or distance fixation. Amblyopia was defined as BCVA ≤ 0.1 logMAR units in one or both eyes, without ocular pathology in either eye. Of the 2363 eligible students, 2260 (95.6%) completed all examinations. The mean age of the students was 12.4 ± 0.6 years. Amblyopia was present in 52 students (2.5%), of whom 33 (63.5%) had unilateral and 19 (36.6%) had bilateral amblyopia. Of those with unilateral amblyopia, 18 (54.5 %) had anisometropia and 7 (21.2%) had strabismus. Of those with bilateral amblyopia, 6 (31.6%) had significant refractive error. Strabismus was present in 108 students (5.0%), of whom 2 (1.9%) had esotropia, 102 (94.4%) had exotropia, 3 (2.8%) had vertical strabismus, and 1 (0.9%) had microstrabismus. Of the 108 students with strabismus, 9 (8.3%) had amblyopia. The cross-sectional ACES which examined the prevalence of amblyopia and strabismus in 7th-grade students in central China revealed the prevalence of strabismus, particularly the proportion of exotropia, to be higher than previously reported.

  4. Comparison of TNM-based stage grouping versus UICC/AJCC stage grouping (7th edition) in malignant parotid gland tumors.

    PubMed

    Kreppel, Matthias; Scheer, Martin; Meyer, Moritz; Stenner, Markus; Wedemeyer, Inga; Drebber, Uta; Semrau, Robert; Odenthal, Margarete; Zöller, Joachim E; Guntinas-Lichius, Orlando; Büttner, Reinhard; Beutner, Dirk

    2013-09-01

    Although the UICC/AJCC's TNM staging of the 7th edition was improved in 2002, there are still shortcomings concerning the prognostic quality. Alternative TNM-based stage-groupings such as the T and N Integer Score (TANIS) where shown to have a better prognostic quality for various kinds of head and neck tumors in the past. The aim of the study was to compare the prognostic value of the 7th edition of the UICC/AJCC TNM-classification for carcinoma of the parotid gland with different TNM-based stage groupings. The retrospective analysis included 180 patients with carcinoma of the parotid gland diagnosed between 1986 and 2007. The stage grouping system of the 7th edition of the UICC/AJCC and TNM-based stage-groupings (TANIS-3, TANIS-8, Snyderman, Berg and Hart) were tested for their prognostic significance. Overall survival (OS) was plotted by Kaplan-Meier analysis. Prognostic factors were identified through univariate and multivariate analysis. In univariate analysis all stage-groupings had a highly significant impact on overall survival (p<0.05), however in multivariate analysis, only the TANIS-8 scheme (p=0.008) and Snyderman scheme (p=0.047) predicted OS, while the UICC/AJCC-classification did not predict OS significantly (p=0.381). In comparison to other TNM-based stage groupings the UICC/AJCC-classification did not provide significant prediction of OS, while alternative stage-groupings such as the TANIS-8 had a higher prognostic value. Copyright © 2013 Elsevier Ltd. All rights reserved.

  5. Proceedings of the 7th International Meeting on Nuclear Reactor Thermal-Hydraulics NURETH-7. Volume 2, Sessions 6-11

    SciTech Connect

    Block, R.C.; Feiner, F.

    1995-09-01

    This document, Volume 2, includes papers presented at the 7th International Meeting on Nuclear Reactor Thermal-Hydraulics (NURETH-7) September 10--15, 1995 at Saratoga Springs, N.Y. The following subjects are discussed: Progress in analytical and experimental work on the fundamentals of nuclear thermal-hydraulics, the development of advanced mathematical and numerical methods, and the application of advancements in the field in the development of novel reactor concepts. Also combined issues of thermal-hydraulics and reactor/power-plant safety, core neutronics and/or radiation. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

  6. Proceedings of the 7th International Meeting on Nuclear Reactor Thermal-Hydraulics NURETH-7. Volume 3, Sessions 12-16

    SciTech Connect

    Block, R.C.; Feiner, F.

    1995-09-01

    This document, Volume 3, includes papers presented at the 7th International Meeting on Nuclear Reactor Thermal-Hydraulics (NURETH-7) September 10--15, 1995 at Saratoga Springs, N.Y. The following subjects are discussed: Progress in analytical and experimental work on the fundamentals of nuclear thermal-hydraulics, the development of advanced mathematical and numerical methods, ad the application of advancements in the field in the development of novel reactor concepts. Also combined issues of thermal-hydraulics and reactor/power-plant safety, core neutronics and/or radiation. Selected abstracts have been indexed separately for inclusion in the Energy Science and Technology Database.

  7. Proceedings of the 7th International Meeting on Nuclear Reactor Thermal-Hydraulics NURETH-7. Volume 1, Sessions 1-5

    SciTech Connect

    Block, R.C.; Feiner, F.

    1995-09-01

    This document, Volume 1, includes papers presented at the 7th International Meeting on Nuclear Reactor Thermal-Hydraulics (NURETH-7) September 10--15, 1995 at Saratoga Springs, N.Y. The following subjects are discussed: Progress in analytical and experimental work on the fundamentals of nuclear thermal-hydraulics, the development of advanced mathematical and numerical methods, and the application of advancements in the field in the development of novel reactor concepts. Also combined issues of thermal-hydraulics and reactor/power-plant safety, core neutronics and/or radiation. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

  8. Proceedings of the Symposium on Training of Nuclear Facility Personnel (7th, Orlando, Florida, April 27-30, 1987).

    ERIC Educational Resources Information Center

    Oak Ridge National Lab., TN.

    These proceedings contain program highlights as well as 45 papers given during six sessions of the Symposium on Training of Nuclear Facility Personnel. The six sessions are entitled: (1) the training challenge; (2) influences on nuclear training; (3) the human factors--training partnership and factors affecting job performance; (4) current…

  9. Human Exploration using Real-Time Robotic Operations (HERRO): A space exploration strategy for the 21st century

    NASA Astrophysics Data System (ADS)

    Schmidt, George R.; Landis, Geoffrey A.; Oleson, Steven R.

    2012-11-01

    This paper presents an exploration strategy for human missions beyond Low Earth Orbit (LEO) and the Moon that combines the best features of human and robotic spaceflight. This "Human Exploration using Real-time Robotic Operations" (HERRO) strategy refrains from placing humans on the surfaces of the Moon and Mars in the near-term. Rather, it focuses on sending piloted spacecraft and crews into orbit around Mars and other exploration targets of interest, and conducting astronaut exploration of the surfaces using telerobots and remotely-controlled systems. By eliminating the significant communications delay or "latency" with Earth due to the speed of light limit, teleoperation provides scientists real-time control of rovers and other sophisticated instruments. This in effect gives them a "virtual presence" on planetary surfaces, and thus expands the scientific return at these destinations. HERRO mitigates several of the major issues that have hindered the progress of human spaceflight beyond Low Earth Orbit (LEO) by: (1) broadening the range of destinations for near-term human missions; (2) reducing cost and risk through less complexity and fewer man-rated elements; (3) offering benefits of human-equivalent in-situ cognition, decision-making and field-work on planetary bodies; (4) providing a simpler approach to returning samples from Mars and planetary surfaces; and (5) facilitating opportunities for international collaboration through contribution of diverse robotic systems. HERRO provides a firm justification for human spaceflight—one that expands the near-term capabilities of scientific exploration while providing the space transportation infrastructure needed for eventual human landings in the future.

  10. Human impacts of hydrometeorological extremes in the Bohemian-Moravian Highlands derived from documentary sources in the 18th-19th centuries

    NASA Astrophysics Data System (ADS)

    Dolák, Lukáš; Brázdil, Rudolf; Valášek, Hubert

    2014-05-01

    The extent of damage caused by hydrometeorological events or extremes (HME) has risen up in the entire world in the last few years. Especially the floods, flash floods, torrential rains and hailstorms are the most typical and one of the most frequent kind of natural disasters in the central Europe. Catastrophes are a part of human history and people were forced to cope with their consequences (e. g. material damage, economical losses, impacts on agriculture and society or losses of human lives). This paper analyses the human impacts of HME in the Bohemian-Moravian Highlands (central part of the Czech Republic) on the basis of documentary sources from the 18th-19th centuries. The paper presents various negative impacts of natural disasters on lives and property and subsequent inconveniences of Czech peasants. The preserved archival documents of estates or domains became the primary sources of data (e. g. taxation reliefs, damaged records, reports of afflicted farmers, administrative correspondence etc.). Particularly taxation reliefs relate to taxation system in the Czech lands during the 17th-19th centuries allowing to farmers to ask for tax alleviation when their crops were significantly damaged by any HME. These archival documents are a highly valuable source for the study of human impacts of natural disasters. Devastating consequences of these extremes affected individual farmers much more than the aristocracy. Floods caused inundations of farmer's fields, meadows, houses and farm buildings, washed away the arable land with crops, caused losses of cattle, clogged the land with gravel and mud and destroyed roads, bridges or agricultural equipment. Afflicted fields became worthless and it took them many years to become became fertile again. Crop was also damaged by hailstorms, droughts or late/early frosts. All these events led to lack of food and seeds in the following year and it meant the decrease of living standard, misery and poverty of farmers. Acquired

  11. Integrating mechanistic and polymorphism data to characterize human genetic susceptibility for environmental chemical risk assessment in the 21st century

    SciTech Connect

    Mortensen, Holly M.; Euling, Susan Y.

    2013-09-15

    Response to environmental chemicals can vary widely among individuals and between population groups. In human health risk assessment, data on susceptibility can be utilized by deriving risk levels based on a study of a susceptible population and/or an uncertainty factor may be applied to account for the lack of information about susceptibility. Defining genetic susceptibility in response to environmental chemicals across human populations is an area of interest in the NAS' new paradigm of toxicity pathway-based risk assessment. Data from high-throughput/high content (HT/HC), including -omics (e.g., genomics, transcriptomics, proteomics, metabolomics) technologies, have been integral to the identification and characterization of drug target and disease loci, and have been successfully utilized to inform the mechanism of action for numerous environmental chemicals. Large-scale population genotyping studies may help to characterize levels of variability across human populations at identified target loci implicated in response to environmental chemicals. By combining mechanistic data for a given environmental chemical with next generation sequencing data that provides human population variation information, one can begin to characterize differential susceptibility due to genetic variability to environmental chemicals within and across genetically heterogeneous human populations. The integration of such data sources will be informative to human health risk assessment.

  12. century drying

    NASA Astrophysics Data System (ADS)

    Cook, Benjamin I.; Smerdon, Jason E.; Seager, Richard; Coats, Sloan

    2014-11-01

    Global warming is expected to increase the frequency and intensity of droughts in the twenty-first century, but the relative contributions from changes in moisture supply (precipitation) versus evaporative demand (potential evapotranspiration; PET) have not been comprehensively assessed. Using output from a suite of general circulation model (GCM) simulations from phase 5 of the Coupled Model Intercomparison Project, projected twenty-first century drying and wetting trends are investigated using two offline indices of surface moisture balance: the Palmer Drought Severity Index (PDSI) and the Standardized Precipitation Evapotranspiration Index (SPEI). PDSI and SPEI projections using precipitation and Penman-Monteith based PET changes from the GCMs generally agree, showing robust cross-model drying in western North America, Central America, the Mediterranean, southern Africa, and the Amazon and robust wetting occurring in the Northern Hemisphere high latitudes and east Africa (PDSI only). The SPEI is more sensitive to PET changes than the PDSI, especially in arid regions such as the Sahara and Middle East. Regional drying and wetting patterns largely mirror the spatially heterogeneous response of precipitation in the models, although drying in the PDSI and SPEI calculations extends beyond the regions of reduced precipitation. This expansion of drying areas is attributed to globally widespread increases in PET, caused by increases in surface net radiation and the vapor pressure deficit. Increased PET not only intensifies drying in areas where precipitation is already reduced, it also drives areas into drought that would otherwise experience little drying or even wetting from precipitation trends alone. This PET amplification effect is largest in the Northern Hemisphere mid-latitudes, and is especially pronounced in western North America, Europe, and southeast China. Compared to PDSI projections using precipitation changes only, the projections incorporating both

  13. Characterizing barrier-island response to storm and human impact: a century of observations from Breton Island, Louisiana

    NASA Astrophysics Data System (ADS)

    Flocks, J. G.; Terrano, J.; Dalyander, S.

    2016-12-01

    Breton Island, a barrier-island located adjacent to the Mississippi River Delta in the Northern Gulf of Mexico, is recognized as a globally important bird habitat, hosting one of largest pelican nesting colonies in Louisiana. Over the past century extensive loss of island acreage has been documented, but the history of change has not been linked to physical drivers. In this study, high-resolution topo-bathymetric lidar and acoustic bathymetry are combined to create digital elevation models (DEMs) that are compared to historical datasets extending to the late 1800s. This analysis reveals shoreline and seafloor change patterns, most notably that island area has decreased by 85% since the early 1900s. This loss is attributed to a decrease in littoral sediment delivery across a shipping channel dredged adjacent to the island in the 1950s and an increase in storm frequency and intensity since the 1990s. In contrast to this long-term decline, island area has doubled in size since 2005, corresponding to a reduction in both storm and dredging activity. The study links island change to erosional processes and demonstrates the influence of short-term change events, both natural and man-made, on long-term barrier-island evolution. Because Breton Island itself has not been altered appreciably by restoration activities, these observations can be applied to natural barrier island systems elsewhere where sufficient monitoring data is not available.

  14. Territorial and land-use rights perspectives on human-chimpanzee-elephant coexistence in West Africa (Guinea, Guinea-Bissau, Senegal, nineteenth to twenty-first centuries).

    PubMed

    Leblan, Vincent

    2016-07-01

    The first part of this article compares the distribution of chimpanzee and elephant populations in reaction to human territorial dynamics of West African trade in parts of nineteenth century Guinea, Guinea-Bissau and Senegal. It answers for this specific region the question of whether present-day situations of close chimpanzee-human spatial proximity are stable or only temporary phenomena in long-term processes of environmental change, and shows that conservation policies centred on either of these two "flagship" species carry radically different ecological, political and territorial implications. The second part shifts to local-level perspectives on human-chimpanzee relationships, emphasizing the land rights contentions and misunderstandings created by the implementation of protected areas at Bossou and in the Boké region of Guinea. These case studies help to look at acts of resistance and local interpretations of primate conservation policies as opportunities to reconsider what is being protected, for what purpose, as whose heritage, and to move towards new and more legitimate opportunities for the implementation of conservation policies.

  15. The Abuse Potential of Prescription Opioids in Humans-Closing in on the First Century of Research.

    PubMed

    Walsh, Sharon L; Babalonis, Shanna

    2017-01-01

    While opioids are very effective analgesics for treating acute pain, humans have struggled with opiate addiction for millenia. An opium abuse epidemic in the early 1900's led the US government to develop a systematic research infrastructure and scientific plan to produce new compounds with analgesic properties but without abuse liability. This review describes the techniques that were developed for testing in the human laboratory, including empirically derived outcome measures and required elements for human abuse potential assessment. The evaluation and characterization of semi-synthetic and synthetic opioids, including full mu opioid agonists, partial agonists and mixed agonist-antagonists, are described across several decades of research. Finally, the prescription opioid epidemic beginning in the 1990's in the US led to a resurgence in abuse potential evaluations, and the application of these methods to the study of novel abuse-deterrent formulations is discussed.

  16. Over the hills and further away from coast: global geospatial patterns of human and environment over the 20th-21st centuries

    NASA Astrophysics Data System (ADS)

    Kummu, Matti; de Moel, Hans; Salvucci, Gianluigi; Viviroli, Daniel; Ward, Philip J.; Varis, Olli

    2016-03-01

    Proximity to the coast and elevation are important geographical considerations for human settlement. Little is known, however, about how spatial variation in these factors exactly relates to human settlements and activities, and how this has developed over time. Such knowledge is important for identifying vulnerable regions that are at risk from phenomena such as food shortages and water stress. Human activities are a key driving force in global change, and thus detailed information on population distribution is an important input to any research framework on global change. In this paper we assess the global geospatial patterns of the distribution of human population and related factors, with regard to the altitude above sea level and proximity to the coast. The investigated factors are physical conditions, urbanisation, agricultural practices, economy, and environmental stress. An important novel element in this study, is that we included the temporal evolution in various factors related to human settlements and agricultural practices over the 20th century, and used projections for some of these factors up to the year 2050. We found population pressure in the proximity of the coast to be somewhat greater than was found in other studies. Yet, the distribution of population, urbanisation and wealth are evolving to become more evenly spread across the globe than they were in the past. Therefore, the commonly believed tendency of accumulation of people and wealth along coasts is not supported by our results. At the same time, food production is becoming increasingly decoupled from the trends in population density. Croplands are spreading from highly populated coastal zones towards inland zones. Our results thus indicate that even though people and wealth continue to accumulate in proximity to the coast, population densities and economic productivity are becoming less diverse in relation to elevation and distance from the coast.

  17. Comparison of Values in 5th, 6th, 7th and 8th Grade Primary Education Music Class Students'? Workbooks According to Rokeach?s and Akbas's Value Classifications

    ERIC Educational Resources Information Center

    Çakirer, H. Serdar

    2014-01-01

    The aim of the present study is to compare the values in the songs of 5th, 6th, 7th and 8th grade primary education music classes students? workbooks according to the value categorizations proposed by Rockeach and Akbas and which values among the categories mentioned are taught to the students in the 5th, 6th, 7th and 8th grade primary education…

  18. Comparison of Values in 5th, 6th, 7th and 8th Grade Primary Education Music Class Students'? Workbooks According to Rokeach?s and Akbas's Value Classifications

    ERIC Educational Resources Information Center

    Çakirer, H. Serdar

    2014-01-01

    The aim of the present study is to compare the values in the songs of 5th, 6th, 7th and 8th grade primary education music classes students? workbooks according to the value categorizations proposed by Rockeach and Akbas and which values among the categories mentioned are taught to the students in the 5th, 6th, 7th and 8th grade primary education…

  19. Comparison of the prognostic value of the 6th and 7th editions of the Union for International Cancer Control TNM staging system in patients with lower esophageal cancer undergoing neoadjuvant chemotherapy followed by surgery.

    PubMed

    Mehta, S P; Jose, P; Mirza, A; Pritchard, S A; Hayden, J D; Grabsch, H I

    2013-01-01

    Carcinoma of the esophagus is classified according to the Union for International Cancer Control (UICC) TNM staging system. The 7th edition of the UICC TNM staging system was published in 2009. This is the first study to compare the prognostic value of the TNM 6th and 7th editions in patients with esophageal carcinoma treated with chemotherapy followed by surgery. Two hundred forty-three patients with esophageal carcinoma were retrospectively selected from two referral centers. All patients received chemotherapy before surgery. Histopathologic data from the resection specimens were retrieved and restaged according to the TNM 7th edition. Disease-specific survival curves were plotted for depth of tumor invasion (ypT), lymph node status (ypN), and ypTNM stage and then compared. Median follow-up after surgery was 2.5 years (range 0.2-9 years). Survival analysis using the log-rank method revealed that there was a significant difference in survival between ypT4 disease and ypT3 disease (P= 0.003), but no difference between ypT0, ypT1, ypT2, and ypT3 categories irrespective of TNM edition used. Survival probability was significantly different between ypN0 and ypN1 (P= 0.001 for TNM 6th and 7th edition), as well as ypN2 and ypN3 (TNM 7th edition, P= 0.004), but not between ypN1 and ypN2 (TNM 7th edition, P= 0.89). Neither the TNM 6th nor 7th edition T staging provides accurate survival probability stratification. However, the advantage of the 7th edition is the introduction of a third tier in survival stratification for patients with nodal involvement. © 2012 Copyright the Authors. Journal compilation © 2012, Wiley Periodicals, Inc. and the International Society for Diseases of the Esophagus.

  20. Toward the 21st Century: Preparing Proactive Visionary Transformational Leaders for Building Learning Communities. Human Resource Development. Orange County Cluster.

    ERIC Educational Resources Information Center

    Groff, Warren H.

    This document describes the Orange County Cluster human resources development (HRD) seminar that was conducted as part of Nova University's nontraditional practitioner-oriented, problem-solving, field-based distance education program in higher education. Discussed first are HRD in the agricultural and business industrial eras and changing HRD…

  1. Integrating mechanistic and polymorphism data to characterize human genetic susceptibility for environmental chemical risk assessment in the 21st century

    EPA Science Inventory

    Response to environmental chemicals can vary widely among individuals and between population groups. In human health risk assessment, data on susceptibility can be utilized by deriving risk levels based on a study of a susceptible population and/or an uncertainty factor may be ap...

  2. Toward the 21st Century: Preparing Proactive Visionary Transformational Leaders for Building Learning Communities. Human Resource Development. Phoenix Cluster.

    ERIC Educational Resources Information Center

    Groff, Warren H.

    This document describes the human resources development (HRD) seminar that has been part of Nova University's nontraditional practitioner-oriented, problem-solving, field-based doctoral program in higher education since 1990. Discussed first are HRD in the agricultural and business industrial eras and changing HRD practices/needs in the context of…

  3. Space Challenge of the 21st Century. Junior Science and Humanities Symposium Information Booklet for SY88-89.

    ERIC Educational Resources Information Center

    Dependents Schools (DOD), Washington, DC. Pacific Region.

    This booklet is a program management tool designed for use by high school students and teachers participating in science research programs throughout the United States as well as overseas. The program consists of a symposium during which students are invited to conduct original research in the sciences, mathematics, humanities, and computer…

  4. The 21st Century Digital Student: Google Books as a Tool in Promoting Undergraduate Research in the Humanities

    ERIC Educational Resources Information Center

    Karpenko, Lara; Dietz, Lauri

    2013-01-01

    In this article, we contend that publically available, mass digitization projects, such as Google Books, present faculty, regardless of their specific institutional context, with an exciting opportunity to promote meaningful undergraduate research in the humanities. By providing a classroom case study and by proposing an institutional model, we…

  5. Integrating mechanistic and polymorphism data to characterize human genetic susceptibility for environmental chemical risk assessment in the 21st century

    EPA Science Inventory

    Response to environmental chemicals can vary widely among individuals and between population groups. In human health risk assessment, data on susceptibility can be utilized by deriving risk levels based on a study of a susceptible population and/or an uncertainty factor may be ap...

  6. 2006 SME annual meeting & 7th ICARD, March 26-29, 2006, St. Louis, Missouri. Pre-prints

    SciTech Connect

    2006-07-01

    Subjects covered by the papers include: enhanced coalbed methane through carbon sequestration, application of laser surface coatings for raw coal screen wear resistance enhancement, application of cross-flow teeter-bed separator in the US coal industry, arsenic removal from drinking water, modelling of fire spread along combustibles in a mine entry, coal's role in sustaining society, real time characterisation of frother bubble thin films, diesel emissions, overcoming stress measurements form underground coal amines, dry jigging coal, estimation of roof strata strength, improving screen bowl centrifuge performance, installation of ventilation shaft at a New Mexico coal mine, evaluation of feasibility of CO{sub 2} sequestration in deep coal, robot-human control interaction in mining operations, small mine and contractor safety, coal dust explosibility meter, US coal mine fatalities versus age of mine, and water and slurry bulkheads in underground coal mines.

  7. Implementation of the 7th edition AJCC staging system: Effects on staging and survival for pT1 melanoma. A Dutch population based study.

    PubMed

    Oude Ophuis, Charlotte M C; Louwman, Marieke W J; Grünhagen, Dirk J; Verhoef, Kees; van Akkooi, Alexander C J

    2017-04-15

    In the 7(th) edition of the AJCC staging system, the mitotic rate criterion replaced Clark level to increase correct classification of high-risk thin melanoma patients (pT1B). Additionally, sentinel node biopsy (SNB) was recommended for nodal staging of pT1B melanomas. The aim of this article was to evaluate the effects on pT1 substaging and clinical implications in the national pT1 melanoma population. All pT1 melanomas diagnosed in the Netherlands between 2003 and 2014 were selected from the Netherlands Cancer Registry (IKNL). Patients were stratified by cohort according to AJCC edition: (1) 2003-2009 (6(th) ) and (2) 2010-2014 (7(th) ). Relative survival was calculated to estimate melanoma-specific survival. A total of 29.546 pT1 melanoma patients were included. The pT1b proportion increased from 10.1% in Cohort 1 to 21.5% in Cohort 2. The proportion of performed SNBs per cohort increased: for pT1b melanomas alone from 4.5% to 13.0%. SNB positivity rate decreased from 10.5% to 8.8% for the entire pT1 population, and for pT1b melanomas from 11.3% to 8.6%. At 5 years, the relative survival rate was similar for pT1a and pT1b in both cohorts, namely, pT1a 100% vs pT1b 97% (Cohort 1), and pT1a 100% vs pT1b 98% (Cohort 2). The 7(th) edition of the AJCC staging system has caused an increased number of patients to undergo SNB, without an increase in SNB positivity rate. Survival between pT1 subgroups remains similar. The mitotic rate criterion for pT1b classification and the recommendation to perform SNB for pT1b melanomas should be reconsidered. © 2017 UICC.

  8. Light for nurses' work in the 21st century: a review of lighting, human vision limitations, and medication administration.

    PubMed

    Graves, Krisanne; Symes, Lene; Cesario, Sandra K

    2014-01-01

    A literature review was conducted to determine the state of the science related to medication errors and light. The limited literature is discussed in relationship to human vision and light needs. Little systematic action has been taken to increase nurses' awareness of the connection between lighting and potential medication errors. Implications for nursing practice and research about light conditions are provided. Interventions from other industries may aid nursing in making decisions about light conditions.

  9. Bio-Anthropological Studies on Human Skeletons from the 6th Century Tomb of Ancient Silla Kingdom in South Korea

    PubMed Central

    Lee, Won-Joon; Woo, Eun Jin; Oh, Chang Seok; Yoo, Jeong A.; Kim, Yi-Suk; Hong, Jong Ha; Yoon, A. Young; Wilkinson, Caroline M.; Ju, Jin Og; Choi, Soon Jo; Lee, Soong Doek; Shin, Dong Hoon

    2016-01-01

    In November and December 2013, unidentified human skeletal remains buried in a mokgwakmyo (a traditional wooden coffin) were unearthed while conducting an archaeological investigation near Gyeongju, which was the capital of the Silla Kingdom (57 BCE– 660 CE) of ancient Korea. The human skeletal remains were preserved in relatively intact condition. In an attempt to obtain biological information on the skeleton, physical anthropological, mitochondrial DNA, stable isotope and craniofacial analyses were carried out. The results indicated that the individual was a female from the Silla period, of 155 ± 5 cm height, who died in her late thirties. The maternal lineage belonged to the haplogroup F1b1a, typical for East Asia, and the diet had been more C3- (wheat, rice and potatoes) than C4-based (maize, millet and other tropical grains). Finally, the face of the individual was reconstructed utilizing the skull (restored from osseous fragments) and three-dimensional computerized modeling system. This study, applying multi-dimensional approaches within an overall bio-anthropological analysis, was the first attempt to collect holistic biological information on human skeletal remains dating to the Silla Kingdom period of ancient Korea. PMID:27249220

  10. Bio-Anthropological Studies on Human Skeletons from the 6th Century Tomb of Ancient Silla Kingdom in South Korea.

    PubMed

    Lee, Won-Joon; Woo, Eun Jin; Oh, Chang Seok; Yoo, Jeong A; Kim, Yi-Suk; Hong, Jong Ha; Yoon, A Young; Wilkinson, Caroline M; Ju, Jin Og; Choi, Soon Jo; Lee, Soong Doek; Shin, Dong Hoon

    2016-01-01

    In November and December 2013, unidentified human skeletal remains buried in a mokgwakmyo (a traditional wooden coffin) were unearthed while conducting an archaeological investigation near Gyeongju, which was the capital of the Silla Kingdom (57 BCE- 660 CE) of ancient Korea. The human skeletal remains were preserved in relatively intact condition. In an attempt to obtain biological information on the skeleton, physical anthropological, mitochondrial DNA, stable isotope and craniofacial analyses were carried out. The results indicated that the individual was a female from the Silla period, of 155 ± 5 cm height, who died in her late thirties. The maternal lineage belonged to the haplogroup F1b1a, typical for East Asia, and the diet had been more C3- (wheat, rice and potatoes) than C4-based (maize, millet and other tropical grains). Finally, the face of the individual was reconstructed utilizing the skull (restored from osseous fragments) and three-dimensional computerized modeling system. This study, applying multi-dimensional approaches within an overall bio-anthropological analysis, was the first attempt to collect holistic biological information on human skeletal remains dating to the Silla Kingdom period of ancient Korea.

  11. Human genome and philosophy: what ethical challenge will human genome studies bring to the medical practices in the 21st century?

    PubMed

    Renzong, Q

    2001-12-01

    A human being or person cannot be reduced to a set of human genes, or human genome. Genetic essentialism is wrong, because as a person the entity should have self-conscious and social interaction capacity which is grown in an interpersonal relationship. Genetic determinism is wrong too, the relationship between a gene and a trait is not a linear model of causation, but rather a non-linear one. Human genome is a complexity system and functions in a complexity system of human body and a complexity of systems of natural/social environment. Genetic determinism also caused the issue of how much responsibility an agent should take for her/his action, and how much degrees of freedom will a human being have. Human genome research caused several conceptual issues. Can we call a gene 'good' or 'bad', 'superior' of 'inferior'? Is a boy who is detected to have the gene of Huntington's chorea or Alzheimer disease a patient? What should the term 'eugenics' mean? What do the terms such as 'gene therapy', 'treatment' and 'enhancement' and 'human cloning' mean etc.? The research of human genome and its application caused and will cause ethical issues. Can human genome research and its application be used for eugenics, or only for the treatment and prevention of diseases? Must the principle of informed consent/choice be insisted in human genome research and its application? How to protecting gene privacy and combating the discrimination on the basis of genes? How to promote the quality between persons, harmony between ethnic groups and peace between countries? How to establish a fair, just, equal and equitable relationship between developing and developed countries in regarding to human genome research and its application?

  12. Sustainability of water uses in managed hydrosystems: human- and climate-induced changes for the mid-21st century

    NASA Astrophysics Data System (ADS)

    Fabre, Julie; Ruelland, Denis; Dezetter, Alain; Grouillet, Benjamin

    2016-08-01

    This paper assesses the sustainability of planned water uses in mesoscale river basins under multiple climate change scenarios, and contributes to determining the possible causes of unsustainability. We propose an assessment grounded in real-world water management issues, with water management scenarios built in collaboration with local water agencies. Furthermore, we present an analysis through indicators that relate to management goals and present the implications of climate uncertainty for our results, furthering the significance of our study for water management. A modeling framework integrating hydro-climatic and human dynamics and accounting for interactions between resource and demand was applied in two basins of different scales and with contrasting water uses: the Herault (2500 km2, France) and the Ebro (85 000 km2, Spain) basins. Natural streamflow was evaluated using a conceptual hydrological model. A demand-driven reservoir management model was designed to account for streamflow regulations from the main dams. Human water demand was estimated from time series of demographic, socioeconomic and climatic data. Environmental flows were accounted for by defining streamflow thresholds under which withdrawals were strictly limited. Finally indicators comparing water availability to demand at strategic resource and demand nodes were computed. This framework was applied under different combinations of climatic and water use scenarios for the mid-21st to differentiate the impacts of climate- and human-induced changes on streamflow and water balance. Results showed that objective monthly environmental flows would be guaranteed in current climate conditions in both basins, yet in several areas this could imply limiting human water uses more than once every 5 years. The impact of the tested climate projections on both water availability and demand could question the water allocations and environmental requirements currently planned for the coming decades. Water

  13. Sustainability of water uses in managed hydrosystems: human- and climate-induced changes for the mid-21st century

    SciTech Connect

    Fabre, Julie; Ruelland, Denis; Dezetter, Alain; Grouillet, Benjamin

    2016-08-02

    This paper assesses the sustainability of planned water uses in mesoscale river basins under multiple climate change scenarios, and contributes to determining the possible causes of unsustainability. We propose an assessment grounded in real-world water management issues, with water management scenarios built in collaboration with local water agencies. Furthermore, we present an analysis through indicators that relate to management goals and present the implications of climate uncertainty for our results, furthering the significance of our study for water management. A modeling framework integrating hydro-climatic and human dynamics and accounting for interactions between resource and demand was applied in two basins of different scales and with contrasting water uses: the Herault (2500 km2, France) and the Ebro (85 000 km2, Spain) basins. Natural streamflow was evaluated using a conceptual hydrological model. A demand-driven reservoir management model was designed to account for streamflow regulations from the main dams. Human water demand was estimated from time series of demographic, socioeconomic and climatic data. Environmental flows were accounted for by defining streamflow thresholds under which withdrawals were strictly limited. Finally indicators comparing water availability to demand at strategic resource and demand nodes were computed. This framework was applied under different combinations of climatic and water use scenarios for the mid-21st to differentiate the impacts of climate- and human-induced changes on streamflow and water balance. Results showed that objective monthly environmental flows would be guaranteed in current climate conditions in both basins, yet in several areas this could imply limiting human water uses more than once every 5 years. The impact of the tested climate projections on both water availability and demand could question the water allocations and environmental requirements currently planned for the

  14. Sustainability of water uses in managed hydrosystems: human- and climate-induced changes for the mid-21st century

    DOE PAGES

    Fabre, Julie; Ruelland, Denis; Dezetter, Alain; ...

    2016-08-02

    This paper assesses the sustainability of planned water uses in mesoscale river basins under multiple climate change scenarios, and contributes to determining the possible causes of unsustainability. We propose an assessment grounded in real-world water management issues, with water management scenarios built in collaboration with local water agencies. Furthermore, we present an analysis through indicators that relate to management goals and present the implications of climate uncertainty for our results, furthering the significance of our study for water management. A modeling framework integrating hydro-climatic and human dynamics and accounting for interactions between resource and demand was applied in two basinsmore » of different scales and with contrasting water uses: the Herault (2500 km2, France) and the Ebro (85 000 km2, Spain) basins. Natural streamflow was evaluated using a conceptual hydrological model. A demand-driven reservoir management model was designed to account for streamflow regulations from the main dams. Human water demand was estimated from time series of demographic, socioeconomic and climatic data. Environmental flows were accounted for by defining streamflow thresholds under which withdrawals were strictly limited. Finally indicators comparing water availability to demand at strategic resource and demand nodes were computed. This framework was applied under different combinations of climatic and water use scenarios for the mid-21st to differentiate the impacts of climate- and human-induced changes on streamflow and water balance. Results showed that objective monthly environmental flows would be guaranteed in current climate conditions in both basins, yet in several areas this could imply limiting human water uses more than once every 5 years. The impact of the tested climate projections on both water availability and demand could question the water allocations and environmental requirements currently planned for the coming decades

  15. Loss of genetic diversity among ocelots in the United States during the 20th century linked to human induced population reductions.

    PubMed

    Janecka, Jan E; Tewes, Michael E; Laack, Linda; Caso, Arturo; Grassman, Lon I; Honeycutt, Rodney L

    2014-01-01

    Ocelots (Leopardus pardalis) in the United States currently exhibit low levels of genetic diversity. One hypothesis for this observation is that habitat fragmentation, resulting from human induced changes in the landscape during the 20(th) century, created island populations with highly reduced gene flow and increased genetic drift and inbreeding. In an effort to investigate this, we used a portion of the mitochondrial control region and 11 autosomal microsatellite loci to examine historical levels of genetic diversity and infer temporal changes in ocelot populations between 1853 and 2005. Levels of genetic diversity were higher in historical ocelot populations than in extant populations from Texas. The earliest documented loss of mitochondrial haplotype diversity occurred at Laguna Atascosa National Wildlife Refuge. The second extant population inhabiting private lands in Willacy County retained higher levels of genetic diversity through the 1990s, but subsequently lost diversity over the next decade. A similar pattern was observed for autosomal microsatellite loci. This supports the argument that low levels of genetic diversity in Texas are related to human induced population reductions and fragmentation, both of which threaten the remaining ocelots in the United States. At this time, the best means of mitigating the continued erosion of genetic variation are translocation of individuals either from larger populations in Mexico to Texas, or between the Texas populations.

  16. The statesman and the ophthalmologist: Gladstone and Magnus on the evolution of human colour vision, one small episode of the nineteenth-century Darwinian debate.

    PubMed

    Bellmer, E H

    1999-01-01

    Among the numerous nineteenth-century sorties into particular aspects of the Darwinian debate are two 1877 publications. The first, Die Geschichtliche Entwickelung des Farbensinnes, was a treatise on the evolutionary development of human colour vision by Hugo Magnus, an obscure German ophthalmologist. The other, The Colour-Sense, was an article by William Ewart Gladstone, the great British statesman. Magnus, working from linguistic science and optical physiology, developed the theory that humankind had passed through successive stages of colour recognition, from none to full perception, brightest colours first. Gladstone supported the theory with data from his studies of Homeric colour words, placing Homer at a very early stage. Their theory was not accepted. It assumed colour vocabulary to be an index of colour recognition, and too little was known about the nature or age of early man. The present study intends to follow this particular episode as an excellent example of the scholarship, argumentation, and limited scientific knowledge of the time, as applied to human evolution.

  17. Loss of Genetic Diversity among Ocelots in the United States during the 20th Century Linked to Human Induced Population Reductions

    PubMed Central

    Janecka, Jan E.; Tewes, Michael E.; Laack, Linda; Caso, Arturo; Grassman, Lon I.; Honeycutt, Rodney L.

    2014-01-01

    Ocelots (Leopardus pardalis) in the United States currently exhibit low levels of genetic diversity. One hypothesis for this observation is that habitat fragmentation, resulting from human induced changes in the landscape during the 20th century, created island populations with highly reduced gene flow and increased genetic drift and inbreeding. In an effort to investigate this, we used a portion of the mitochondrial control region and 11 autosomal microsatellite loci to examine historical levels of genetic diversity and infer temporal changes in ocelot populations between 1853 and 2005. Levels of genetic diversity were higher in historical ocelot populations than in extant populations from Texas. The earliest documented loss of mitochondrial haplotype diversity occurred at Laguna Atascosa National Wildlife Refuge. The second extant population inhabiting private lands in Willacy County retained higher levels of genetic diversity through the 1990s, but subsequently lost diversity over the next decade. A similar pattern was observed for autosomal microsatellite loci. This supports the argument that low levels of genetic diversity in Texas are related to human induced population reductions and fragmentation, both of which threaten the remaining ocelots in the United States. At this time, the best means of mitigating the continued erosion of genetic variation are translocation of individuals either from larger populations in Mexico to Texas, or between the Texas populations. PMID:24586737

  18. Kuru in the 21st century--an acquired human prion disease with very long incubation periods.

    PubMed

    Collinge, John; Whitfield, Jerome; McKintosh, Edward; Beck, John; Mead, Simon; Thomas, Dafydd J; Alpers, Michael P

    2006-06-24

    Kuru provides the principal experience of epidemic human prion disease. Its incidence has steadily fallen after the abrupt cessation of its route of transmission (endocannibalism) in Papua New Guinea in the 1950s. The onset of variant Creutzfeldt-Jakob disease (vCJD), and the unknown prevalence of infection after the extensive dietary exposure to bovine spongiform encephalopathy (BSE) prions in the UK, has led to renewed interest in kuru. We investigated possible incubation periods, pathogenesis, and genetic susceptibility factors in kuru patients in Papua New Guinea. We strengthened active kuru surveillance in 1996 with an expanded field team to investigate all suspected patients. Detailed histories of residence and exposure to mortuary feasts were obtained together with serial neurological examination, if possible. We identified 11 patients with kuru from July, 1996, to June, 2004, all living in the South Fore. All patients were born before the cessation of cannibalism in the late 1950s. The minimum estimated incubation periods ranged from 34 to 41 years. However, likely incubation periods in men ranged from 39 to 56 years and could have been up to 7 years longer. PRNP analysis showed that most patients with kuru were heterozygous at polymorphic codon 129, a genotype associated with extended incubation periods and resistance to prion disease. Incubation periods of infection with human prions can exceed 50 years. In human infection with BSE prions, species-barrier effects, which are characteristic of cross-species transmission, would be expected to further increase the mean and range of incubation periods, compared with recycling of prions within species. These data should inform attempts to model variant CJD epidemiology.

  19. The 7th International Conference on Nanomaterials by Severe Plastic Deformation: a report of the International NanoSPD Steering Committee

    NASA Astrophysics Data System (ADS)

    Valiev, R. Z.; Langdon, T. G.

    2017-05-01

    The 7th International Conference on Nanomaterials by Severe Plastic Deformation (NanoSPD7) is hosted by the University of Sydney (Australia) following a series of earlier conferences: in Moscow (1999), Vienna (2002), Fukuoka (2005), Goslar (2008), Nanjing (2011) and Metz (2014). This introductory paper reports on several major developments in NanoSPD activities as well as on recent NanoSPD citation data which illustrate the growth and expansion of this important research area for the time period following the conference in Metz. Close attention is given to topics of nanostructuring of metals by SPD processing for advanced properties and on new trends in developing SPD techniques for practical applications. A special concern of the committee is the appropriate terminology that is used in this new field of science and engineering as well as the innovation potential of recent applied studies and developments.

  20. Climate, people, fire and vegetation: new insights into vegetation dynamics in the Eastern Mediterranean since the 1st century AD

    NASA Astrophysics Data System (ADS)

    Bakker, J.; Paulissen, E.; Kaniewski, D.; Poblome, J.; De Laet, V.; Verstraeten, G.; Waelkens, M.

    2012-08-01

    Anatolia forms a bridge between Europe, Africa and Asia and is influenced by all three continents in terms of climate, vegetation and human civilisation. Unfortunately, well dated palynological records focussing on the period from the end of the classical Roman period until subrecent times are rare for Anatolia and completely absent for southwest Turkey, resulting in a lacuna in knowledge concerning the interactions of climatic change, human impact, and environmental change in this important region. Two well dated palaeoecological records from the Western Taurus Mountains, Turkey, provide a first relatively detailed record of vegetation dynamics from late Roman times until the present in SW Turkey. Combining pollen, non-pollen palynomorphs, charcoal, sedimentological, archaeological data, and newly developed multivariate numerical analyses, allows for the disentangling of climatic and anthropogenic influences on vegetation change. Results show both the regional pollen signal as well as local soil sediment characteristics respond accurately to shifts in regional climatic conditions. Both climatic as well as anthropogenic change had a strong influence on vegetation dynamics and land use. A moist environmental trend during the late 3rd century caused an increase in marshes and wetlands in the moister valley floors, limiting possibilities for intensive crop cultivation at such locations. A mid 7th century shift to pastoralism coincided with a climatic deterioration as well as the start of Arab incursions into the region, the former driving the way in which the vegetation developed afterwards. Resurgence in agriculture was observed in the study during the mid 10th century AD, coinciding with the Medieval Climate Anomaly. An abrupt mid 12th century decrease in agriculture is linked to socio-political change, rather than the onset of the Little Ice Age. Similarly, gradual deforestation occurring from the 16th century onwards has been linked to changes in lands use during

  1. Abstracts presented at the 7th World Alliance for Risk Factor Surveillance (WARFS) Global Conference. October 16-19, 2011. Toronto, Ontario, Canada.

    PubMed

    2012-01-01

    The 7th World Alliance for Risk Factor Surveillance (WARFS) Global Conference, hosted by the Public Health Agency of Canada, was held in Toronto, Ontario, Canada, from October 16 to 19, 2011. Previous WARFS conferences were held in USA (1999), Finland (2001), Australia (2003), Uruguay (2005) and Italy (2007, 2009). WARFS is a global working group on surveillance under the International Union for Health Promotion and Education (IUHPE) It supports the development of risk factor surveillance as a tool for evidence-based public health, acknowledging the importance of this source of information to inform, monitor and evaluate disease prevention and health promotion policies and programs. The theme of the 2011 Global Conference was the role of surveillance in the promotion of health. The Global Conference had 146 registered participants, making it the second most attended WARFS conference in its history. Over the three days, participants attended oral and poster presentations from 30 countries. The conference would not have been possible without the hard work of the International Scientific Committee and the Local Organizing Committee. To highlight the importance and the significance of this conference at an international level, Chronic Diseases and Injuries in Canada (CDIC) is pleased to publish this supplementary issue, which contains 70 abstracts presented at the 7th WARFS Global Conference. In the spirit the Global Conference, this collection of abstracts brings together surveillance material on risk factors, chronic diseases, infectious diseases and injuries from around the world. By making these abstracts widely available, CDIC hopes to further the conference objectives through a continued dialogue between those interested in linking risk factor surveillance to health promotion.

  2. Evaluation of the 7th American Joint Committee on cancer TNM staging system for prostate cancer in point of classification of bladder neck invasion.

    PubMed

    Chung, Mun Su; Lee, Seung Hwan; Lee, Dong Hoon; Chung, Byung Ha

    2013-02-01

    To assess the validity of the 7th edition of the American Joint Committee on Cancer TNM staging system for prostate cancer, paying special attention to bladder neck invasion, in an Asian population. Clinicopathologic data of 368 men who underwent radical prostatectomy between 2003 and 2011 at our institution were reviewed. The main interest of this study was to confirm that both isolated positive bladder neck margin and positive bladder neck margin associated with other surgical margin have more favorable biochemical outcomes than seminal vesicle invasion (pT3b). The 3-year biochemical recurrence-free survival for men with organ confined disease, extraprostatic extension, isolated positive bladder neck margin, positive bladder neck margin with other surgical margin and seminal vesicle invasion was 88.9, 74.8, 51.2, 19.4 and 18.8%, respectively. On multivariate analysis, the increased risk of progression associated with an isolated positive bladder neck margin (hazard ratio 4.34, 95% confidence interval 1.40-13.46, P = 0.011) was less than that of seminal vesicle invasion (hazard ratio 9.67, 95% confidence interval 3.70-25.25, P < 0.001). As for the positive bladder neck margin with other surgical margin, the increased risk of progression (hazard ratio 9.32, 95% confidence interval 3.50-24.82, P < 0.001) was similar to that of men with seminal vesicle invasion. In our study, men with isolated positive bladder neck margin and positive bladder neck margin plus other surgical margin had no worse biochemical outcomes than those with seminal vesicle invasion (pT3b). It is reasonable to classify prostate cancer with bladder neck invasion (the 6th American Joint Committee on Cancer edition pT4 category) into the 7th edition pT3 category.

  3. Water scarcity hotspots travel downstream due to human interventions in the 20th and 21st century

    PubMed Central

    Veldkamp, T.I.E.; Wada, Y.; Aerts, J.C.J.H.; Döll, P.; Gosling, S. N.; Liu, J.; Masaki, Y.; Oki, T.; Ostberg, S.; Pokhrel, Y.; Satoh, Y.; Kim, H.; Ward, P. J.

    2017-01-01

    Water scarcity is rapidly increasing in many regions. In a novel, multi-model assessment, we examine how human interventions (HI: land use and land cover change, man-made reservoirs and human water use) affected monthly river water availability and water scarcity over the period 1971–2010. Here we show that HI drastically change the critical dimensions of water scarcity, aggravating water scarcity for 8.8% (7.4–16.5%) of the global population but alleviating it for another 8.3% (6.4–15.8%). Positive impacts of HI mostly occur upstream, whereas HI aggravate water scarcity downstream; HI cause water scarcity to travel downstream. Attribution of water scarcity changes to HI components is complex and varies among the hydrological models. Seasonal variation in impacts and dominant HI components is also substantial. A thorough consideration of the spatially and temporally varying interactions among HI components and of uncertainties is therefore crucial for the success of water scarcity adaptation by HI. PMID:28643784

  4. Water Scarcity Hotspots Travel Downstream Due to Human Interventions in the 20th and 21st Century

    NASA Technical Reports Server (NTRS)

    Veldkamp, T. I. E.; Wada, Y.; Aerts, J. C. J. H.; Doell, P.; Gosling, S. N.; Liu, J.; Masaki, Y.; Oki, T.; Ostberg, S.; Pokhrel, Y.; hide

    2017-01-01

    Water scarcity is rapidly increasing in many regions. In a novel, multi-model assessment, we examine how human interventions (HI: land use and land cover change, man-made reservoirs and human water use) affected monthly river water availability and water scarcity over the period 1971 - 2010. Here we show that HI drastically change the critical dimensions of water scarcity, aggravating water scarcity for 8.8%(7.4 - 16.5 %) ) of the global population but alleviating it for another 8.3 % (6.4 -15.8 %). Positive impacts of HI mostly occur upstream, whereas HI aggravate water scarcity downstream; HI cause water scarcity to travel downstream. Attribution of water scarcity changes to HI components is complex and varies among the hydrological models. Seasonal variation in impacts and dominant HI components is also substantial. A thorough consideration of the spatially and temporally varying interactions among HI components and of uncertainties is therefore crucial for the success of water scarcity adaptation by HI.

  5. Water scarcity hotspots travel downstream due to human interventions in the 20th and 21st century.

    PubMed

    Veldkamp, T I E; Wada, Y; Aerts, J C J H; Döll, P; Gosling, S N; Liu, J; Masaki, Y; Oki, T; Ostberg, S; Pokhrel, Y; Satoh, Y; Kim, H; Ward, P J

    2017-06-15

    Water scarcity is rapidly increasing in many regions. In a novel, multi-model assessment, we examine how human interventions (HI: land use and land cover change, man-made reservoirs and human water use) affected monthly river water availability and water scarcity over the period 1971-2010. Here we show that HI drastically change the critical dimensions of water scarcity, aggravating water scarcity for 8.8% (7.4-16.5%) of the global population but alleviating it for another 8.3% (6.4-15.8%). Positive impacts of HI mostly occur upstream, whereas HI aggravate water scarcity downstream; HI cause water scarcity to travel downstream. Attribution of water scarcity changes to HI components is complex and varies among the hydrological models. Seasonal variation in impacts and dominant HI components is also substantial. A thorough consideration of the spatially and temporally varying interactions among HI components and of uncertainties is therefore crucial for the success of water scarcity adaptation by HI.

  6. Water scarcity hotspots travel downstream due to human interventions in the 20th and 21st century

    NASA Astrophysics Data System (ADS)

    Veldkamp, T. I. E.; Wada, Y.; Aerts, J. C. J. H.; Döll, P.; Gosling, S. N.; Liu, J.; Masaki, Y.; Oki, T.; Ostberg, S.; Pokhrel, Y.; Satoh, Y.; Kim, H.; Ward, P. J.

    2017-06-01

    Water scarcity is rapidly increasing in many regions. In a novel, multi-model assessment, we examine how human interventions (HI: land use and land cover change, man-made reservoirs and human water use) affected monthly river water availability and water scarcity over the period 1971-2010. Here we show that HI drastically change the critical dimensions of water scarcity, aggravating water scarcity for 8.8% (7.4-16.5%) of the global population but alleviating it for another 8.3% (6.4-15.8%). Positive impacts of HI mostly occur upstream, whereas HI aggravate water scarcity downstream; HI cause water scarcity to travel downstream. Attribution of water scarcity changes to HI components is complex and varies among the hydrological models. Seasonal variation in impacts and dominant HI components is also substantial. A thorough consideration of the spatially and temporally varying interactions among HI components and of uncertainties is therefore crucial for the success of water scarcity adaptation by HI.

  7. Validation and comparison of the 7th and 8th edition of AJCC staging systems for non-metastatic nasopharyngeal carcinoma, and proposed staging systems from Hong Kong, Guangzhou, and Guangxi.

    PubMed

    OuYang, Pu-Yun; Xiao, Yao; You, Kai-Yun; Zhang, Lu-Ning; Lan, Xiao-Wen; Zhang, Xiao-Min; Xie, Fang-Yun

    2017-09-01

    We aimed to validate and compare the 7th and 8th edition of AJCC staging systems for non-metastatic nasopharyngeal carcinoma, and proposed staging systems from Hong Kong, Guangzhou, and Guangxi. We retrospectively included 899 patients treated between November 5, 2002 and May 27, 2010. Separation and discrimination of each staging system in overall survival were primarily compared. Compared with the 7th AJCC, the 8th AJCC and all proposed staging systems well separated across T-classification. T-classification from Guangzhou seemed to perform best in discrimination (C-index 0.6454), followed by the 8th AJCC (0.6451), the 7th AJCC (0.6386), Hong Kong (0.6376) and Guangxi (0.5889). For N-classification, no staging systems improved the weakness of the 7th AJCC in separating N2 and N1, except that suggestion from Guangzhou showed higher potential (P=0.096). Besides, N-classification from Guangzhou had a C-index of 0.6444, larger than that of the 8th AJCC (0.6235), the 7th AJCC (0.6179), Hong Kong (0.6175) and Guangxi (0.6175). Accordingly, stage group of staging system from Guangzhou showed higher discrimination (C-index 0.6839), compared with the 8th AJCC (0.6791), the 7th AJCC (0.6766), Hong Kong (0.6765) and Guangxi (0.6688), despite that stage I and II remained inseparable (P=0.322). The 8th AJCC staging system appeared to be better than the 7th AJCC. But the proposed staging system from Guangzhou was more likely to improve the separation and discrimination abilities. Copyright © 2017. Published by Elsevier Ltd.

  8. A century of ecosystem change: human and seabird impacts on plant species extirpation and invasion on islands

    PubMed Central

    Bennett, Joseph R.; Blight, Louise K.; Giesen, Marissa; Janssen, Michael H.; Schaminée, Joop J.H.J.; Arcese, Peter

    2016-01-01

    We used 116 years of floral and faunal records from Mandarte Island, British Columbia, Canada, to estimate the indirect effects of humans on plant communities via their effects on the population size of a surface-nesting, colonial seabird, the Glaucous-winged gull (Larus glaucescens). Comparing current to historical records revealed 18 extirpations of native plant species (32% of species historically present), 31 exotic species introductions, and one case of exotic introduction followed by extirpation. Contemporary surveys indicated that native species cover declined dramatically from 1986 to 2006, coincident with the extirpation of ‘old-growth’ conifers. Because vegetation change co-occurred with an increasing gull population locally and regionally, we tested several predictions from the hypothesis that the presence and activities of seabirds help to explain those changes. Specifically, we predicted that on Mandarte and nearby islands with gull colonies, we should observe higher nutrient loading and exotic plant species richness and cover than on nearby islands without gull colonies, as a consequence of competitive dominance in species adapted to high soil nitrogen and trampling. As predicted, we found that native plant species cover and richness were lower, and exotic species cover and richness higher, on islands with versus without gull colonies. In addition, we found that soil carbon and nitrogen on islands with nesting gulls were positively related to soil depth and exotic species richness and cover across plots and islands. Our results support earlier suggestions that nesting seabirds can drive rapid change in insular plant communities by increasing nutrients and disturbing vegetation, and that human activities that affect seabird abundance may therefore indirectly affect plant community composition on islands with seabird colonies. PMID:27547531

  9. Natural and Human Impacts on the Coastal Environment of Taiwan Recorded in Marine Sediments During the last century

    NASA Astrophysics Data System (ADS)

    Li, H.; Chen, Z.; Huh, C.; Chen, K.; Lin, Y.; Hsu, F.

    2012-12-01

    Located at tropical-to-subtropical region on the Pacific rim, Taiwan has very high erosion rate due to steep topography and heavy rainfall especially typhoons. The high sedimentation rates in Taiwan Strait allow us to retrieve high-resolution marine records which reveal natural changes and human impacts on the coastal environment of Taiwan over the past 100 years. Five gravity and box cores well dated by 210Pb and 137Cs methods were analyzed for elemental concentrations in the acid-leachable phase, total organic carbon (TOC), δ13CTOC, δ13C and δ18O of carbonates. The results show that: (1) Positive correlation between TOC and typhoon rainfall since 1940 indicate that decline of vegetation coverage resulted in intensification of soil erosion. The δ13CTOC values illustrate that the organic carbon in the sediments was originated mainly from land input. (2) The δ18O difference between foraminiferal shells and carbonate grains can be used for rainfall reconstruction. (3) The Ca concentrations mainly from carbonates in the sediments were decreased since AD 1940, reflecting changes in sedimentary source and ocean acidfication. As development of the land use, more and more soil erosion caused depletion of authigenic marine sediments in the coast region. Ocean acidification led to less carbonate formation in seawater. (4) Since 1920, Pb concentration rapidly increased and peaked at ~1970 as Pb input from gasoline usage. Pb concentration dropped from 1970 to 1975 perhaps due to unleaded gasoline replacement. (5) In the nearshore environment, heavy metals such as Mn, Cu and Pb in the acid-leachable phase of the sediments strongly increased from 1950 to 1965 then kept relatively high level, reflecting heavy metal contamination from industrial source. The human impact on the coastal region of Taiwan not only caused changes in marine sediments and ocean water, but also disturbed the marine ecosystem. This study has been funded by NSC-100-3113-E-002-009: Study of CO2 capture

  10. [Health, human development, and governance in Latin America and the Caribbean at the beginning of the 21st century].

    PubMed

    Casas-Zamora, Juan Antonio

    2002-01-01

    The issue of the reciprocal relationship between health and development has recently taken on greater importance in Latin America and the Caribbean (LAC), given the persistence of extreme poverty and the political and social difficulties due to macroeconomic imbalances and crises of governance. This piece reviews concepts of sustainable human development, social determinants of health in general and of health inequities in particular (gender, ethnic group, income level), and the relationship between health and economic growth in the medium term and the long term. An analysis is made of how persistent poverty in countries of LAC relates to disparities in health conditions, access to health services, and health care financing, as well as to such health determinants as nutrition and environmental sanitation. Health inequities most strongly affect the most excluded and vulnerable sectors of the population. In the face of this situation, the author stresses that putting a priority on health inequities is vital to safeguarding the governability and the social and political stability of countries in LAC in the next decade.

  11. Microbiology Meets Archaeology: Soil Microbial Communities Reveal Different Human Activities at Archaic Monte Iato (Sixth Century BC).

    PubMed

    Margesin, Rosa; Siles, José A; Cajthaml, Tomas; Öhlinger, Birgit; Kistler, Erich

    2017-05-01

    Microbial ecology has been recognized as useful in archaeological studies. At Archaic Monte Iato in Western Sicily, a native (indigenous) building was discovered. The objective of this study was the first examination of soil microbial communities related to this building. Soil samples were collected from archaeological layers at a ritual deposit (food waste disposal) in the main room and above the fireplace in the annex. Microbial soil characterization included abundance (cellular phospholipid fatty acids (PLFA), viable bacterial counts), activity (physiological profiles, enzyme activities of viable bacteria), diversity, and community structure (bacterial and fungal Illumina amplicon sequencing, identification of viable bacteria). PLFA-derived microbial abundance was lower in soils from the fireplace than in soils from the deposit; the opposite was observed with culturable bacteria. Microbial communities in soils from the fireplace had a higher ability to metabolize carboxylic and acetic acids, while those in soils from the deposit metabolized preferentially carbohydrates. The lower deposit layer was characterized by higher total microbial and bacterial abundance and bacterial richness and by a different carbohydrate metabolization profile compared to the upper deposit layer. Microbial community structures in the fireplace were similar and could be distinguished from those in the two deposit layers, which had different microbial communities. Our data confirmed our hypothesis that human consumption habits left traces on microbiota in the archaeological evidence; therefore, microbiological residues as part of the so-called ecofacts are, like artifacts, key indicators of consumer behavior in the past.

  12. Global spread of hypoxia in freshwater ecosystems during the last three centuries is caused by rising local human pressure.

    PubMed

    Jenny, Jean-Philippe; Francus, Pierre; Normandeau, Alexandre; Lapointe, François; Perga, Marie-Elodie; Ojala, Antti; Schimmelmann, Arndt; Zolitschka, Bernd

    2016-04-01

    The spread of hypoxia is a threat to aquatic ecosystem functions and services as well as to biodiversity. However, sparse long-term monitoring of lake ecosystems has prevented reconstruction of global hypoxia dynamics while inhibiting investigations into its causes and assessing the resilience capacity of these systems. This study compiles the onset and duration of hypoxia recorded in sediments of 365 lakes worldwide since AD 1700, showing that lacustrine hypoxia started spreading before AD 1900, 70 years prior to hypoxia in coastal zones. This study also shows that the increase of human activities and nutrient release is leading to hypoxia onset. No correlations were found with changes in precipitation or temperature. There is no evidence for a post-1980s return to well-oxygenated lacustrine conditions in industrialized countries despite the implementation of restoration programs. The apparent establishment of stable hypoxic conditions prior to AD 1900 highlights the challenges of a growing nutrient demand, accompanied by increasing global nutrient emissions of our industrialized societies, and climate change. © 2015 John Wiley & Sons Ltd.

  13. Spatial-Temporal Heterogeneity in Regional Watershed Phosphorus Cycles Driven by Changes in Human Activity over the Past Century

    NASA Astrophysics Data System (ADS)

    Hale, R. L.; Grimm, N. B.; Vorosmarty, C. J.

    2014-12-01

    An ongoing challenge for society is to harness the benefits of phosphorus (P) while minimizing negative effects on downstream ecosystems. To meet this challenge we must understand the controls on the delivery of anthropogenic P from landscapes to downstream ecosystems. We used a model that incorporates P inputs to watersheds, hydrology, and infrastructure (sewers, waste-water treatment plants, and reservoirs) to reconstruct historic P yields for the northeastern U.S. from 1930 to 2002. At the regional scale, increases in P inputs were paralleled by increased fractional retention, thus P loading to the coast did not increase significantly. We found that temporal variation in regional P yield was correlated with P inputs. Spatial patterns of watershed P yields were best predicted by inputs, but the correlation between inputs and yields in space weakened over time, due to infrastructure development. Although the magnitude of infrastructure effect was small, its role changed over time and was important in creating spatial and temporal heterogeneity in input-yield relationships. We then conducted a hierarchical cluster analysis to identify a typology of anthropogenic P cycling, using data on P inputs (fertilizer, livestock feed, and human food), infrastructure (dams, wastewater treatment plants, sewers), and hydrology (runoff coefficient). We identified 6 key types of watersheds that varied significantly in climate, infrastructure, and the types and amounts of P inputs. Annual watershed P yields and retention varied significantly across watershed types. Although land cover varied significantly across typologies, clusters based on land cover alone did not explain P budget patterns, suggesting that this variable is insufficient to understand patterns of P cycling across large spatial scales. Furthermore, clusters varied over time as patterns of climate, P use, and infrastructure changed. Our results demonstrate that the drivers of P cycles are spatially and temporally

  14. Vegetation changes and human impact inferred from an oxbow lake in southwestern Amazonia, Brazil since the 19th century

    NASA Astrophysics Data System (ADS)

    Rodríguez-Zorro, Paula A.; Enters, Dirk; Hermanowski, Barbara; da Costa, Marcondes Lima; Behling, Hermann

    2015-10-01

    Pollen and X-ray fluorescence spectrometry (XRF) analyses from a 272 cm-long sediment core of Lago Amapá, an oxbow lake in western Amazonia, reveal the first palaeoecological investigation of late Holocene sediments in Acre state, Brazil. Radiocarbon dating of older sediments failed due to re-deposition of organic material but a historical map suggests that lacustrine deposition started at 1900 AD. We detected two periods of changes in sediment and vegetation, dominated by pioneer taxa especially Cecropia. The first period around 1900 AD is documenting an initial oxbow lake, with regular fluvial input (high Ti) and low accumulation of organic matter (low inc/coh ratio). During that period Andean pollen taxa originating from Peruvian Andean headwaters were deposited. A fully lacustrine phase started about 1950 AD and is characterized by prolonged periods of stagnant water (low Fe/Mn ratio). The increase of pioneer taxa, sedimentation rates and a reduction of most of the XRF element counts point to a period during which Lago Amapá was a more isolated lake which was flooded only during exceptional severe flood events and is catching mainly anthropogenic disturbances. The extensive human influence during this period was assumed by 1) the high occurrence of pioneer taxa and the absence of charcoal which could indicate changes in vegetation possibly as a result of logging, 2) the Ca and Ti/K ratio which reflect changes to a local sediment source, and 3) comparison of Landsat images from the last 30 years which shows broad changes in vegetation cover and land transformation in the peripheral areas of the oxbow lake.

  15. Understanding Edward Muybridge: historical review of behavioral alterations after a 19th-century head injury and their multifactorial influence on human life and culture.

    PubMed

    Manjila, Sunil; Singh, Gagandeep; Alkhachroum, Ayham M; Ramos-Estebanez, Ciro

    2015-07-01

    Edward Muybridge was an Anglo-American photographer, well known for his pioneering contributions in photography and his invention of the "zoopraxiscope," a forerunner of motion pictures. However, this 19th-century genius, with two original patents in photographic technology, made outstanding contributions in art and neurology alike, the latter being seldom acknowledged. A head injury that he sustained changed his behavior and artistic expression. The shift of his interests from animal motion photography to human locomotion and gait remains a pivotal milestone in our understanding of patterns in biomechanics and clinical neurology, while his own behavioral patterns, owing to an injury to the orbitofrontal cortex, remain a mystery even for cognitive neurologists. The behavioral changes he exhibited and the legal conundrum that followed, including a murder of which he was acquitted, all depict the complexities of his personality and impact of frontal lobe injuries. This article highlights the life journey of Muybridge, drawing parallels with Phineas Gage, whose penetrating head injury has been studied widely. The wide sojourn of Muybridge also illustrates the strong connections that he maintained with Stanford and Pennsylvania universities, which were later considered pinnacles of higher education on the two coasts of the United States.

  16. Evaluation of elemental status of ancient human bone samples from Northeastern Hungary dated to the 10th century AD by XRF

    NASA Astrophysics Data System (ADS)

    János, I.; Szathmáry, L.; Nádas, E.; Béni, A.; Dinya, Z.; Máthé, E.

    2011-11-01

    The present study is a multielemental analysis of bone samples belonging to skeletal individuals originating from two contemporaneous (10th century AD) cemeteries (Tiszavasvári Nagy-Gyepáros and Nagycserkesz-Nádasibokor sites) in Northeastern Hungary, using the XRF analytical technique. Emitted X-rays were detected in order to determine the elemental composition of bones and to appreciate the possible influence of the burial environment on the elemental content of the human skeletal remains. Lumbar vertebral bodies were used for analysis. Applying the ED(P)XRF technique concentration of the following elements were determined: P, Ca, K, Na, Mg, Al, Cl, Mn, Fe, Zn, Br and Sr. The results indicated post mortem mineral exchange between the burial environment (soil) and bones (e.g. the enhanced levels of Fe and Mn) and referred to diagenetic alteration processes during burials. However, other elements such as Zn, Sr and Br seemed to be accumulated during the past life. On the basis of statistical analysis, clear separation could not be observed between the two excavation sites in their bone elemental concentrations which denoted similar diagenetic influences, environmental conditions. The enhanced levels of Sr might be connected with the past dietary habits, especially consumption of plant food.

  17. Historical flood data series of Eastern Spanish Coast (14th-20th centuries). Improving identification of climatic patterns and human factors of flood events from primary documentary sources

    NASA Astrophysics Data System (ADS)

    Alberola, Armando; Barriendos, Mariano; Gil-Guirado, Salvador; Pérez-Morales, Alfredo; Balasch, Carles; Castelltort, Xavier; Mazón, Jordi; Pino, David; Lluís Ruiz-Bellet, Josep; Tuset, Jordi

    2016-04-01

    Historical flood data series of Eastern Spanish Coast (14th-20th centuries). Improving identification of climatic patterns and human factors of flood events from primary documentary sources Armando Alberola, Barriendos, M., Gil-Guirado, S., Pérez Morales, A., Balasch, C., Castelltort, X., Mazón, J., Pino, D., Ruiz-Bellet, J.L., Tuset, J. Historical flood events in eastern spanish coast have been studied by different research groups and projects. Complexity of flood processes, involving atmospheric, surface and human factors, is not easily understandable when long time series are required. Present analysis from PREDIFLOOD Project Consortium defines a new step of flood event databases: Improved access to primary (documentary) and secondary (bibliographical) sources, data collection for all possible locations where floods are detected, and improved system of classification (Barriendos et al., 2014). A first analysis is applied to 8 selected flood series. Long chronologies from PREDIFLOOD Project for Catalonia region (Girona, Barcelona, Tarragona, Lleida, Tortosa). In addition, to cover all sector of spanish mediterranean coast, we introduce Valencia city in Turia River basin. South Eastern sector is cover with Murcia and Caravaca cities, Segura River basin. Extension of area under study required contributions of research teams experienced in work of documentary primary sources (Alberola, 2006; Gil-Guirado, 2013). Flood frequency analysis for long scale periods show natural climatic oscillations into so-called Little Ice Age. There are general patterns, affecting most of basins, but also some local anomalies or singularities. To explain these differences and analogies it is not enough to use purely climatic factors. In this way, we analyze human factors that have been able to influence the variability of floods along last 6 centuries (demography, hydraulic infrastructures, urban development...). This approach improves strongly understanding of mechanisms producing

  18. Socio-metabolic transitions during the 20th century and their impacts on the scale of human resource use

    NASA Astrophysics Data System (ADS)

    Fischer Kowalski, M.; Haas, W.; Wiedenhofer, D.; Krausmann, F.

    2012-04-01

    , while the next transition (away from fossil fuels) is yet barely visible. A continuation on this global pathway, by recent UNEP scenarios, would lead to a tripling of annual resource extraction by 2050. This urgently calls for a next socio-metabolic transition away from fossil fuels and away from wastefully high metabolic rates - a transition on a par with the grand transitions between socio-metabolic regimes in human history.

  19. [Prognostic value of AJCC TNM Staging 7th edition in limited-stage small cell lung cancer: validation in 437 patients].

    PubMed

    Zhang, Wenjue; Zhu, Hui; Zhou, Zongmei; Feng, Qinfu; Chen, Dongfu; Zhang, Hongxing; Xiao, Zefen; Wang, Lühua

    2015-12-01

    To explore the impact of AJCC TNM Staging 7th edition on survival outcome of limited stage small cell lung cancer (SCLC). Four hundred and thirty-seven SCLC patients with completed diagnosis and treatment data treated in our department between January 1996 and December 2006 were reclassified according to the AJCC TNM Staging 7th edition. The patients of stages IA, IB, IIA, IIB, IIIA, IIIB were 8, 44, 7, 64, 192 cases, respectively. Kaplan-Meier method was used for survival analysis and log-rank test was used to identify the prognostic factors. The survival rate was determined using chi-square test. The median follow-up time was 64 months. The median survival time was 26.2 months and median progression free survival time was 13.7 months. The 1-, 2- and 5-year overall survival rates were 86.0%, 52.7%, and 29.7%, respectively. The log-rank test showed that TNM stage is a statistically significant prognostic factor for OS in LS-SCLC (P<0.001). TNM staging system generally allowed a good separation in pairwise comparison for OS between successive stages except there was no significant difference between stages I and II (P=0.061). The 5-year progression free survival rates of patients of stage I, II, IIIA and IIIB were 53.2%, 43.2%, 16.8%, and 10.9%, respectively. TNM stage also was a statistically significant prognostic factor for PFS in LS-SCLC (P<0.001), but there was no significant difference between successive stages (P>0.05 for all). The T staging confirmed significant influence on OS (P<0.001) with no significant difference between successive stages (P>0.05 for all), while T stage was not a significant prognostic factor for PFS in the LS-SCLC patients (P=0.194). N stage also had a significant influence on OS (P<0.001), but with no significant differences between successive stages except N1 and N2 (P=0.001). N staging also showed significant influence on PFS (P=0.001), but with no significant difference between successive stages (P>0.05) except that between the 5

  20. A multi-proxy lake core record from Lago Lungo, Rieti Basin, Lazio, Italy and its relation to human activities in the catchment during the last century

    NASA Astrophysics Data System (ADS)

    Noble, Paula; Tunno, Irene; Mensing, Scott; Piovesan, Gianluca

    2016-04-01

    The lakes of the Rieti Basin have experienced extensive human modification dating back to pre-Roman times, yet lake archives indicate that the most profound changes to the aquatic ecosystem have occurred during the last century. Analysis of the upper ˜120 cm segment of a sediment core from Lago Lungo, dating back to ˜1830 CE, show changes in water quality and hydrologic inflow largely attributed to 20th century reclamation and land use activities. Lago Lungo is a shallow, small, eutrophic, hard water lake situated in an intermontaine alluvial plain ˜90 km NE of Rome. It is one of several remnant lakes in a poorly drained wetland area fed by numerous springs. Reclamation activities over the last century have substantially altered the drainage network affecting water delivery to the lakes and their connectivity. There are 3 interesting signals in the core. First, small Stephanodiscus species, associated with hypereutrophic conditions, appear after 1950, peak ˜1990, and may be attributed to increased use of chemical fertilizers and intensification of local agriculture. Elemental proxies from scanning XRF data (abundances of Ti, Si/Ti, and Ca) are consistent with increased eutrophication starting ˜1950. A decline in Stephanodicsus after 1990 reflects some improvement to the water quality following the lake's incorporation into a nature preserve and creation of a narrow vegetation buffer. Intermittent water quality measurements from 1982 onward corroborate the changes in trophic status interpreted from the core record. Second, a large change in the core stratigraphy, elemental geochemistry, and diatom composition occurs ˜1940 and is associated with several major reclamation efforts, including the rerouting of the Santa Susanna channel, which redirected large volumes of artesian inflows away from the lakes and estuarine system. Upstream, dams on the Turano and Salto rivers were also constructed, further affecting hydrological inflows into the basin. From ˜1900

  1. Staging of lung cancer in a tertiary care setting in Sri Lanka, using TNM 7th edition. A comparison against TNM6

    PubMed Central

    2012-01-01

    Background Lung cancer is a leading cause of cancer-related mortality in Sri Lanka and throughout the world. The latest staging system for lung cancer is the tumor node metastasis (TNM) 7th edition in which there are major changes to the previous version. The objective of our study was to find out the implications of TNM7th edition on lung cancer staging in a resource limited setting, and to compare it with the previous TNM 6th edition. Methods Patients with histologically proven lung cancer consecutively presented to respiratory unit of Teaching Hospital Kandy, Sri Lanka were recruited to the study over a period of one year from April 2010 to March 2011. They were staged using CT, ultrasound scan of abdomen, bronchoscopy and CT spine and brain when necessary. Staging was done using TNM 7 as well as TNM6. Surgical or non-surgical treatment arms were decided on staging and the number of patients in each treatment arm was compared between the two staging systems. Results Out of 62 patients, thirty four patients (54%) had metastatic disease and 19 (30%) of them had pleural effusions (M1a), while 15 (24%) had distant metastasis (M1b). When compared to TNM6 there was no difference in the number of patients in T1 category, but the number in T2 was higher in TNM7 (25 Vs 20). Similarly the number in T3 group was higher in TNM7 (11 Vs 5) and the number in M category was doubled (34 Vs 17 [Chi-6.46, p = 0.011]) compared to TNM 6. The number of patients suitable for surgery were 17(27.5%) in TNM 7 and 18(29%) [Chi-0.02, p = 0.88] in TNM6. Conclusions This study shows that a significant proportion of patients were having advanced disease with distant metastasis on presentation. The number of patients falling to stage IV is significantly higher when staged with TNM7 but there was no significant difference in the number of patients undergoing surgery when TNM 7 was used compared to TNM6. PMID:22414168

  2. Evaluating Earth and Space Sciences STEM Research Communication in 7th-12th Grade Rural Mississippi Classrooms and Resulting Student Attitudinal Impacts

    NASA Astrophysics Data System (ADS)

    Radencic, S.; McNeal, K. S.

    2013-05-01

    Observation and evaluation of STEM graduate students from Mississippi State University communicating their research of the Earth and Space Sciences in rural 7th-12th grade classrooms participating in the Initiating New Science Partnerships in Rural Education (INSPIRE) NSF GK-12 project. The methods they utilize to communicate their STEM research includes introducing new technologies and inquiry based learning experiences. These communication experiences have been observed and evaluated using two observational systems, the Mathematics Science Classroom Observational Profile System (M-SCOPS) and the Presentation Skills Protocol (PSP). M-SCOPS has been used over the first three years of the project to evaluate what Earth and Space research the STEM graduate students communicate in classroom activities along with how they are introducing STEM research through a variety of communication methods and levels of understanding. PSP, which INSPIRE began using this year, evaluates and provides feedback to the STEM graduate students on their communication during these classroom experiences using a rubric covering a range of skills for successful communication. PSP also allows the participating INSPIRE teacher partners to provide feedback to the STEM graduate students about development of their communication skills over the course of the year. In addition to feedback from the INSPIRE project and participating teachers, the STEM graduate students have the opportunity to evaluate their personal communication skills through video documentation to determine specific skills they would like to improve. Another area of research to be discussed is how the STEM graduate students communicating Earth and Space sciences research in the participating classrooms is impacting student attitudes about science and mathematics over the last three years. Student Attitudinal Surveys (SAS) are administered as a pre-evaluation tool in the fall when the STEM graduate students first enter into their

  3. [Prevalence of smoking habits of Upper Austria students of the 7th and 8th grade and effect of smoking habits of family and peers].

    PubMed

    Zidek, T; Haidinger, G; Zacharasiewicz, A; Waldhör, T; Vutuc, C

    2000-01-01

    The aim of the study was to explore the prevalence of different smoking habits in a population of Austrian pupils, 12 to 15 years old, and the relationship of familial and peer group smoking customs with these habits. In 1997 a population-based survey (International Study of Asthma and Allergies in Childhood, ISAAC) was conducted of all 7th and 8th grade school children of a district of Upper Austria. Information on the smoking habits of the adolescents, the family members, and of the peer as well as smoking habits of the teacher, gender, and age of the children was collected. The overall-prevalence of having ever smoked in this population is 57.8%. The percentage of eversmokers among the 12-year-olds is 50%. This amount increases to 63.8% among the 14- to 15-year-olds. The odds ratios for smoking daily is highest among those whose best friend smokes (OR: 70.63, CI: 9.19, 542.40). The risk of daily smoking increases also if the siblings of the juvenile (OR: 4.71, CI: 1.15, 19.35) or the mother (OR: 4.95, CI: 1.67, 14.70) smoke. If the father smokes the risk to smoke monthly is increased (OR: 2.09, CI: 1.28, 3.40). These results point to the fact that smoking prevention programes should take into account the influence of peers and family of the adolescents.

  4. One-year oral toxicity study on a genetically modified maize MON810 variety in Wistar Han RCC rats (EU 7th Framework Programme project GRACE).

    PubMed

    Zeljenková, Dagmar; Aláčová, Radka; Ondrejková, Júlia; Ambrušová, Katarína; Bartušová, Mária; Kebis, Anton; Kovrižnych, Jevgenij; Rollerová, Eva; Szabová, Elena; Wimmerová, Soňa; Černák, Martin; Krivošíková, Zora; Kuricová, Miroslava; Líšková, Aurélia; Spustová, Viera; Tulinská, Jana; Levkut, Mikuláš; Révajová, Viera; Ševčíková, Zuzana; Schmidt, Kerstin; Schmidtke, Jörg; Schmidt, Paul; La Paz, Jose Luis; Corujo, Maria; Pla, Maria; Kleter, Gijs A; Kok, Esther J; Sharbati, Jutta; Bohmer, Marc; Bohmer, Nils; Einspanier, Ralf; Adel-Patient, Karine; Spök, Armin; Pöting, Annette; Kohl, Christian; Wilhelm, Ralf; Schiemann, Joachim; Steinberg, Pablo

    2016-10-01

    The GRACE (GMO Risk Assessment and Communication of Evidence; www.grace-fp7.eu ) project was funded by the European Commission within the 7th Framework Programme. A key objective of GRACE was to conduct 90-day animal feeding trials, animal studies with an extended time frame as well as analytical, in vitro and in silico studies on genetically modified (GM) maize in order to comparatively evaluate their use in GM plant risk assessment. In the present study, the results of a 1-year feeding trial with a GM maize MON810 variety, its near-isogenic non-GM comparator and an additional conventional maize variety are presented. The feeding trials were performed by taking into account the guidance for such studies published by the EFSA Scientific Committee in 2011 and the OECD Test Guideline 452. The results obtained show that the MON810 maize at a level of up to 33 % in the diet did not induce adverse effects in male and female Wistar Han RCC rats after a chronic exposure.

  5. Ninety-day oral toxicity studies on two genetically modified maize MON810 varieties in Wistar Han RCC rats (EU 7th Framework Programme project GRACE).

    PubMed

    Zeljenková, Dagmar; Ambrušová, Katarína; Bartušová, Mária; Kebis, Anton; Kovrižnych, Jevgenij; Krivošíková, Zora; Kuricová, Miroslava; Líšková, Aurélia; Rollerová, Eva; Spustová, Viera; Szabová, Elena; Tulinská, Jana; Wimmerová, Soňa; Levkut, Mikuláš; Révajová, Viera; Ševčíková, Zuzana; Schmidt, Kerstin; Schmidtke, Jörg; La Paz, Jose Luis; Corujo, Maria; Pla, Maria; Kleter, Gijs A; Kok, Esther J; Sharbati, Jutta; Hanisch, Carlos; Einspanier, Ralf; Adel-Patient, Karine; Wal, Jean-Michel; Spök, Armin; Pöting, Annette; Kohl, Christian; Wilhelm, Ralf; Schiemann, Joachim; Steinberg, Pablo

    2014-12-01

    The GMO Risk Assessment and Communication of Evidence (GRACE; www.grace-fp7.eu ) project is funded by the European Commission within the 7th Framework Programme. A key objective of GRACE is to conduct 90-day animal feeding trials, animal studies with an extended time frame as well as analytical, in vitro and in silico studies on genetically modified (GM) maize in order to comparatively evaluate their use in GM plant risk assessment. In the present study, the results of two 90-day feeding trials with two different GM maize MON810 varieties, their near-isogenic non-GM varieties and four additional conventional maize varieties are presented. The feeding trials were performed by taking into account the guidance for such studies published by the EFSA Scientific Committee in 2011 and the OECD Test Guideline 408. The results obtained show that the MON810 maize at a level of up to 33 % in the diet did not induce adverse effects in male and female Wistar Han RCC rats after subchronic exposure, independently of the two different genetic backgrounds of the event.

  6. Solar particle event detected by ALTEA on board the International Space Station. The March 7th, 2012 X5.4 flare

    NASA Astrophysics Data System (ADS)

    Di Fino, Luca; Zaconte, Veronica; Stangalini, Marco; Sparvoli, Roberta; Picozza, Piergiorgio; Piazzesi, Roberto; Narici, Livio; Larosa, Marianna; Del Moro, Dario; Casolino, Marco; Berrilli, Francesco; Scardigli, Stefano

    2014-05-01

    Context. Solar activity poses substantial risk for astronauts of the International Space Station (ISS) both on board and during extravehicular activity. An accurate assessment of the charged radiation flux in space habitats is necessary to determine the risk and the specific type of radiation exposure of ISS crew members, and to develop ways to protect future crews for planetary missions, even in case of high solar activity. Aims: To reduce the present-day uncertainties about the nature and magnitude of the particle fluxes in space habitats during a solar event, it is fundamental to measure those fluxes in situ. Methods: The ALTEA (Anomalous Long Term Effects on Astronauts) experiment on board the ISS is an active detector composed of six silicon telescopes and is able to follow the dynamics of the radiation flux. During its operation in 2012 a number of flux peaks were detected in correspondence with solar events. Results: We present in this work an analysis of the ALTEA data measured during the March 7th, 2012 solar event, produced by NOAA AR11429. Conclusions: During this event, the flux was enhanced tenfold with respect to ``quiet Sun'' conditions, producing strong dose increases at high geomagnetic latitudes.

  7. Unique Characteristics of the Pyrrolysine System in the 7th Order of Methanogens: Implications for the Evolution of a Genetic Code Expansion Cassette

    PubMed Central

    Borrel, Guillaume; Gaci, Nadia; Peyret, Pierre; O'Toole, Paul W.; Gribaldo, Simonetta

    2014-01-01

    Pyrrolysine (Pyl), the 22nd proteogenic amino acid, was restricted until recently to few organisms. Its translational use necessitates the presence of enzymes for synthesizing it from lysine, a dedicated amber stop codon suppressor tRNA, and a specific amino-acyl tRNA synthetase. The three genomes of the recently proposed Thermoplasmata-related 7th order of methanogens contain the complete genetic set for Pyl synthesis and its translational use. Here, we have analyzed the genomic features of the Pyl-coding system in these three genomes with those previously known from Bacteria and Archaea and analyzed the phylogeny of each component. This shows unique peculiarities, notably an amber tRNAPyl with an imperfect anticodon stem and a shortened tRNAPyl synthetase. Phylogenetic analysis indicates that a Pyl-coding system was present in the ancestor of the seventh order of methanogens and appears more closely related to Bacteria than to Methanosarcinaceae, suggesting the involvement of lateral gene transfer in the spreading of pyrrolysine between the two prokaryotic domains. We propose that the Pyl-coding system likely emerged once in Archaea, in a hydrogenotrophic and methanol-H2-dependent methylotrophic methanogen. The close relationship between methanogenesis and the Pyl system provides a possible example of expansion of a still evolving genetic code, shaped by metabolic requirements. PMID:24669202

  8. Clinical outcomes for rectal carcinoid tumors according to a new (AJCC 7th edition) TNM staging system: a single institutional analysis of 122 patients.

    PubMed

    Kim, Min Sung; Hur, Hyuk; Min, Byung Soh; Baik, Seung Hyuk; Lee, Kang Young; Kim, Nam Kyu

    2013-06-01

    This study aimed to describe clinical outcomes of rectal carcinoids according to the 7th American Joint Council on Cancer (AJCC) TNM staging system. We retrospectively reviewed 122 patients who were treated for rectal carcinoids between 1995 and 2010. Among 122 patients, 81.2% (n = 99) were classified as stage I, 4.9% (n = 6) as stage II, 11.5% (n = 14) as stage III, and 2.5% (n = 3) as stage IV. Lymph node (LN) metastasis rates for pT1a, 1b, 2, and 3 stages were 1.2% (1/85), 16.7% (3/18), 0% (0/4) and 84.6% (11/13), respectively. The 5-year overall survival (OS) rate was 88.4%. The 5-year OS rates were estimated to be 100%, 80%, 51.4% and 0% for stage I, II, III, and IV, respectively (P < 0.001). The 5-year disease-free survival (DFS) rate was 82.3%. The 5-year DFS rates were estimated to be 97.7%, 62.5%, 17.1%, and 0% for stages I, II, III, and IV, respectively (P < 0.001). Using the new TNM stage, we confirmed a prognostic difference in LN metastasis rates, OS, and DFS for rectal carcinoids. In clinical practice, the new TNM stage can be very useful for predicting prognosis. Copyright © 2013 Wiley Periodicals, Inc.

  9. Prognostic factors in advanced pharyngeal and oral cavity cancer; significance of multimodality imaging in terms of 7th edition of TNM.

    PubMed

    Gődény, Maria

    2014-04-28

    As with most cancers the prognosis in pharyngeal and oral cavity cancer largely depends on tumour stage. Physical examination, including endoscopy should be combined with technical radiologic imaging to record the precise extent of tumour. The TNM staging system of the head and neck region is, in fact, an anatomic staging system that describes the anatomic extent of the primary tumour as well as the involvement of regional lymph nodes and distant metastases. Modifications in the TNM staging system should consider not only the expert opinions and published reports in the literature but the technical advances in technology for improved assessment of tumour extent and the shifting paradigms in therapeutic strategies. "T" stage of the tumour is defined by its size, the depth of the invasion and the involvement of vital structures. In the 7th edition of TNM classification, for stage T4 tumors (larger than 4 cm), subcategories a and b were introduced to indicate the involvement of vital structures and their suitability for surgical resection (except for nasopharynx cancer). Nodal metastasis is the most important predictor of outcome for squamous cell cancer of the head and neck.

  10. Influence of human-climate system feedbacks on predicted 21st century land use/land cover trajectories, fossil fuel emissions, and climate change

    NASA Astrophysics Data System (ADS)

    Thornton, P. E.; Edmonds, J. A.; Collins, W.; Janetos, A. C.; Hurtt, G. C.; Shi, X.; Mao, J.; Thomson, A. M.; Calvin, K. V.; Bond-Lamberty, B. P.; Chini, L. P.

    2012-12-01

    The interaction between human system and climate system models in the current climate change assessment framework is based on one-way coupling, in which estimates of human actions such as land use and land cover change (LULCC), and fossil fuel combustion, are generated by integrated assessment models (IAMs) and passed as forcing functions to Earth system models (ESMs). By neglecting the return flow of information from the physical climate and biogeochemical systems, inconsistencies are inevitably introduced in this one-way coupling approach. We are developing an integrated Earth System Model (iESM) to characterize, address, and minimize these inconsistencies, by merging the capabilities of IAMs and ESMs in a single coupling framework. Here, we have applied the iESM to estimate the impact of two-way interactions between LULCC and climate on the evolution of the coupled human-climate system over the 21st century. Our simulations followed the Reference Concentration Pathway (RCP) 4.5 scenario, a member of the recent Climate Model Intercomparison Project v5 (CMIP5) family of climate system scenarios. We compared a traditional RCP4.5 simulation from the Community Earth System Model v1 (CESM1) coupled climate-biogeochemistry model with an iESM simulation in which the estimation of LULCC dynamics was performed synchronously with the physical climate simulation. As a first step in a series of planned coupling exercises, we evaluated the influence of a very simple feedback mechanism, in which information generated within the physical-biogeochemical model components was passed back to the human dimensions component by way of a set of scalars capturing the effects of changing climate on terrestrial ecosystem productivity. This mechanism provides a signal within the human system component model modifying crop yields, bioenergy potential, and pasture and forest productivity in response to climate change, including changes in temperature, precipitation, CO2 concentrations, and

  11. Reading & Accountability: Improving 21st Century Schools. Hearing before the Committee on Education and the Workforce. House of Representatives, One Hundred Seventh Congress, First Session (Marietta, Georgia, February 20, 2001).

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Committee on Education and the Workforce.

    A hearing, held in Marietta, Georgia, on February 20, 2001, before the Committee on Education and the Workforce, House of Representatives, 107th Congress, dealt with reading and accountability and improving 21st century schools. These proceedings of the hearing contain the following: Statement of Congressman Bob Barr, 7th District of Georgia, U.S.…

  12. The Sommersdorf mummies—An interdisciplinary investigation on human remains from a 17th-19th century aristocratic crypt in southern Germany

    PubMed Central

    Kellinghaus, Manuel; Jackowski, Christian; Shved, Natallia; Rühli, Frank; Maixner, Frank; Zink, Albert; Rosendahl, Wilfried; Lösch, Sandra

    2017-01-01

    Sommersdorf Castle (Bavaria, Germany) is a medieval castle complex which has been inhabited by the aristocratic family von Crailsheim. The deceased were entombed in a crypt located in the parapets underneath the castle’s church, resulting in mummification of the bodies. Based on the family chronicle and oral history, identities have been ascribed to the mummies. The aim of the study is therefore to test the accuracy of the historical records in comparison to archaeological, anthropological and genetic data. Today, the crypt houses eleven wooden coffins from the 17th to 19th century AD. In ten of these, mummified and scattered human remains were found. Archive records were studied in order to identify names, ancestry, titles, occupation, date of birth and death, and place of interment of the individuals. The coffins were visually inspected and dated by typo-chronology, and the mummified and scattered skeletal remains were subjected to a physical anthropological examination. In total, the crypt contains the remains of a minimum number of nine individuals, among them three adult males, five adult females and one infant. A detailed scientific examination, including prior conservation, ancient DNA analyses, and computed tomography (CT), was performed on five mummies. By means of the CT data age at death, sex, body height, pathologies, and anatomical variants were investigated. CT analysis further showed that the bodies were naturally mummified. Mitochondrial DNA analyses revealed that the tested individuals are not maternally related. In addition, health, living conditions and circumstances of death of the entombed individuals could be highlighted. Being confronted with the strengths, weaknesses and limitations of each methodological approach, probable identification was achieved in two cases. PMID:28859116

  13. The Sommersdorf mummies-An interdisciplinary investigation on human remains from a 17th-19th century aristocratic crypt in southern Germany.

    PubMed

    Alterauge, Amelie; Kellinghaus, Manuel; Jackowski, Christian; Shved, Natallia; Rühli, Frank; Maixner, Frank; Zink, Albert; Rosendahl, Wilfried; Lösch, Sandra

    2017-01-01

    Sommersdorf Castle (Bavaria, Germany) is a medieval castle complex which has been inhabited by the aristocratic family von Crailsheim. The deceased were entombed in a crypt located in the parapets underneath the castle's church, resulting in mummification of the bodies. Based on the family chronicle and oral history, identities have been ascribed to the mummies. The aim of the study is therefore to test the accuracy of the historical records in comparison to archaeological, anthropological and genetic data. Today, the crypt houses eleven wooden coffins from the 17th to 19th century AD. In ten of these, mummified and scattered human remains were found. Archive records were studied in order to identify names, ancestry, titles, occupation, date of birth and death, and place of interment of the individuals. The coffins were visually inspected and dated by typo-chronology, and the mummified and scattered skeletal remains were subjected to a physical anthropological examination. In total, the crypt contains the remains of a minimum number of nine individuals, among them three adult males, five adult females and one infant. A detailed scientific examination, including prior conservation, ancient DNA analyses, and computed tomography (CT), was performed on five mummies. By means of the CT data age at death, sex, body height, pathologies, and anatomical variants were investigated. CT analysis further showed that the bodies were naturally mummified. Mitochondrial DNA analyses revealed that the tested individuals are not maternally related. In addition, health, living conditions and circumstances of death of the entombed individuals could be highlighted. Being confronted with the strengths, weaknesses and limitations of each methodological approach, probable identification was achieved in two cases.

  14. A century scale human-induced hydrological and ecological changes of wetlands of two large river basins in Australia (Murray) and China (Yangtze): development of an adaptive water resource management framework

    NASA Astrophysics Data System (ADS)

    Kattel, G. R.; Dong, X.; Yang, X.

    2015-08-01

    Recently, the provision of food and water resources of two of the world's large river basins, the Murray and the Yangtze, has been significantly altered through widespread landscape modification. Long-term sedimentary archives, dating back to past centuries, from wetlands of these river basins reveal that rapid, basin-wide development has reduced resilience of biological communities, resulting in considerable decline in ecosystem services, including water quality. In particular, large-scale human disturbance to river systems, due to river regulation during the mid-20th century, has transformed the hydrology of rivers and wetlands, causing widespread disturbance to aquatic biological communities. Historical changes of cladoceran zooplankton (water fleas) were used to assess the hydrology and ecology of three Murray and Yangtze River wetlands over the past century. Subfossil assemblages of cladocerans retrieved from sediment cores (94, 45 and 65 cm) of three wetlands: Kings Billabong (Murray), Zhangdu and Liangzi Lakes (Yangtze) strongly responded to hydrological changes of the river after the mid-20th century. River regulation caused by construction of dams and weirs, and river channel modifications has led to hydrological alterations. The hydrological disturbances were either: (1) a prolonged inundation of wetlands, or (2) reduced river flow, which caused variability in wetland depth. These phenomena subsequently transformed the natural wetland habitats, leading to a switch in cladoceran assemblages preferring poor water quality and eutrophication. An adaptive water resource management framework for both of these river basins has been proposed to restore or optimize the conditions of wetland ecosystems impacted by 20th century human disturbance and climate change.

  15. Comparative Evaluation of Microshear Bond Strength of 5(th), 6(th) and 7(th) Generation Bonding Agents to Coronal Dentin Versus Dentin at Floor of Pulp Chamber: An In vitro Study.

    PubMed

    Deepa, Velagala Lakshmi; Damaraju, Bhargavi; Priyadharsini, Bollu Indira; Subbarao, Vummidisetti V; Raju, K Rama Krishna

    2014-09-01

    Lack of seal and adhesion between the final restoration and tooth structure adversely affects the results of root canal treatment. Lots of adhesive bonding agents are marketed to overcome this deficiency and achieve successful restoration. So the study compares and evaluates the micro shear bond strength of coronal dentin and pulp chamber dentin using three different generation dentin bonding systems and to know clinical efficiency for clinical use. DIFFERENT GENERATION DENTIN BONDING SYSTEMS USED WERE: (1) One bottle total etch system (XP Bond-5(th) generation), (2) Two-step self-etch system (Clearfil SE Bond-6(th) generation) and (3) All-in-one system (G Bond-7(th) generation). Thirty human mandibular molars were collected out of which sixty samples were prepared by sectioning each tooth into coronal dentin and pulpal floor dentin. They were divided into two major groups. Group I: 30 Coronal dentin samples. Group II:30 Pulpal floor dentin samples. Both the groups were further subdivided depending on the bonding agent used. Subgroup Ia:XP Bond, Subgroup Ib:Clearfil SE Bond, Subgroup Ic:G Bond, Subgroup IIa:XP Bond, Subgroup IIb:Clearfil SE Bond, Subgroup IIc:G Bond. Resin composite was bonded to these samples and tested for micro-shear bond strength. The mean bond strengths and standard deviations were calculated and analyzed using one-way ANOVA test and Student's t-test (unpaired) and honestly significant difference post-hoc tests. Coronal dentin showed higher values of micro shear bond strength than the pulpal floor dentin. All-in-one system (G Bond) showed least bond strength values to both the regions coronal dentin and pulpal floor dentin. Factors affecting the shear bond strength are dependent on material (adhesive system), substrate depth and adhesive/depth interaction. Hence composition and substrate treatment should be considered for good adhesive. Chemical composition of adhesive system determines clinical successes.

  16. Comparative Evaluation of Microshear Bond Strength of 5th, 6th and 7th Generation Bonding Agents to Coronal Dentin Versus Dentin at Floor of Pulp Chamber: An In vitro Study

    PubMed Central

    Deepa, Velagala Lakshmi; Damaraju, Bhargavi; Priyadharsini, Bollu Indira; Subbarao, Vummidisetti V; Raju, K Rama Krishna

    2014-01-01

    Background: Lack of seal and adhesion between the final restoration and tooth structure adversely affects the results of root canal treatment. Lots of adhesive bonding agents are marketed to overcome this deficiency and achieve successful restoration. So the study compares and evaluates the micro shear bond strength of coronal dentin and pulp chamber dentin using three different generation dentin bonding systems and to know clinical efficiency for clinical use. Materials and Methods: Different generation dentin bonding systems used were: (1) One bottle total etch system (XP Bond-5th generation), (2) Two-step self-etch system (Clearfil SE Bond-6th generation) and (3) All-in-one system (G Bond-7th generation). Thirty human mandibular molars were collected out of which sixty samples were prepared by sectioning each tooth into coronal dentin and pulpal floor dentin. They were divided into two major groups. Group I: 30 Coronal dentin samples. Group II:30 Pulpal floor dentin samples. Both the groups were further subdivided depending on the bonding agent used. Subgroup Ia:XP Bond, Subgroup Ib:Clearfil SE Bond, Subgroup Ic:G Bond, Subgroup IIa:XP Bond, Subgroup IIb:Clearfil SE Bond, Subgroup IIc:G Bond. Resin composite was bonded to these samples and tested for micro-shear bond strength. The mean bond strengths and standard deviations were calculated and analyzed using one-way ANOVA test and Student’s t-test (unpaired) and honestly significant difference post-hoc tests. Results: Coronal dentin showed higher values of micro shear bond strength than the pulpal floor dentin. All-in-one system (G Bond) showed least bond strength values to both the regions coronal dentin and pulpal floor dentin. Conclusion: Factors affecting the shear bond strength are dependent on material (adhesive system), substrate depth and adhesive/depth interaction. Hence composition and substrate treatment should be considered for good adhesive. Chemical composition of adhesive system determines

  17. The management century.

    PubMed

    Kiechel, Walter

    2012-11-01

    In 1886, addressing the nascent American Society of Mechanical Engineers, Henry R. Towne proposed that "the management of works" be considered a modern art--thereby heralding the Management Century, when management as we know it came into being and shaped the world in which we work. Kiechel, a past editorial director of Harvard Business Publishing, elucidates the three eras that punctuate this period: the years leading up to World War II, during which scientific exactitude gave wings to a new managerial elite; the early postwar decades, managerialism's apogee of self-confidence and a time when wartime principles of strategy were adapted, sometimes ruthlessly, to the running of companies; and the 1980s to the present, years that saw fast-moving changes, disequilibrium, and a servitude to market forces but also ushered in globalism, unprecedented innovation, and heightened expectations about how workers are to be treated. Along the way he examines the contributions of thinkers such as Frederick Taylor, Elton Mayo, Peter Drucker, and Michael Porter. What lies ahead? Perhaps the biggest challenge facing the 21st-century company, Kiechel posits, is to truly free the spark of human imagination from the organization's tidal pull toward the status quo. There's almost always a better way, he concludes--and management will continue to seek it.

  18. Science diplomacy in the 21st century.

    PubMed

    Fedoroff, Nina V

    2009-01-09

    Science diplomacy is the use of scientific collaborations among nations to address the common problems facing 21(st) century humanity and to build constructive international partnerships. There are many ways that scientists can contribute to this process.

  19. [Richard Freiherr v. Krafft-Ebing and Sigmund Freud--discourse on the "normality" and "perversion" of human sexuality at the close of the 19th century and the beginning of the 20th century].

    PubMed

    Kapfhammer, Hans-Peter

    2015-01-01

    Sexuality has been defined a central feature of personal identity since the epoch of enlightenment and has gradually become a decisive issue also in societal and political terms. A major transfer from religion and religious institutions to medicine and medical experts and later on to neuropsychiatrists has to be underlined in the primary position to assess "normal" and "deviant" manifestations of sexuality. Richard Freiherr von Krafft-Ebing and Sigmund Freund play an eminent role in this "discourse on sexuality" (M. Foucault) during the nineteenth and beginning twentieth century on the way to modern sexology. Within this overarching context Krafft-Ebing's and Freud's theoretical conceptualizations of sexuality and perversion will be sketched and basic clinical and societal implications there out will be discussed.

  20. Industrial Arts: "Youth's Gateway to the Future." Addresses and Proceedings of the 40th National and 7th International Conference of the American Industrial Arts Association (Atlanta, Georgia, February 27-March 3, 1978).

    ERIC Educational Resources Information Center

    Northern Kentucky Univ., Highland Heights.

    Included in this document are the addresses and proceedings of the 40th National and 7th International Annual Conference of the American Industrial Arts Association. The proceedings are organized by the following subject groups: career education, curriculum, drafting, electricity/electronics, elementary school industrial arts, energy, evaluation,…

  1. Biomedical Challenges Presented by the American Indian, Proceedings of the Special Session of the PAHO Advisory Committee on Medical Research (7th, Washington, D.C., June 25, 1968).

    ERIC Educational Resources Information Center

    Pan American Health Organization, Washington, DC.

    At each meeting of the Pan American Health Organization Advisory Committee on Medical Research, a special 1-day session is held on a topic chosen by the committee as being of particular interest. At the 7th meeting, which convened in June of 1968 in Washington, D.C., the session surveyed the origin, present distribution, and principal biological…

  2. The Role of a Relative Age Effect in the 7th International Children’s Winter Games 2016 and the Influence of Biological Maturity Status on Selection

    PubMed Central

    Müller, Lisa; Hildebrandt, Carolin; Raschner, Christian

    2017-01-01

    The aim of this study was to analyse the role of a relative age effect (RAE) and to investigate the influence of biological maturity status on the RAE at the 7th International Children`s Winter Games. The birth dates of all 572 participants (365 males, 207 females) were analysed, and the biological maturity status of 384 athletes (243 males, 141 females) was assessed by the age at peak height velocity (APHV) method. A RAE was present in the total sample (χ2 = 67.81; p < 0.001), and among both male (χ2 = 49.02; p < 0.001) and female athletes (χ2 = 37.00; p < 0.001) as well as for strength- (χ2 = 56.46; p < 0.001), endurance- (χ2 = 20.48; p = 0.039) and technique-related types of sports (χ2 = 20.48; p = 0.041). No significant differences in biological maturity status were present between the male athletes of single relative age quarters. Among the female athletes a significant difference was present (F = 5.94, p < 0.001); relatively younger female athletes had significantly lower values in the APHV, which indicated that they were maturing earlier. However, when dividing the athletes into normal, early and late maturing athletes, it could be seen that among the relatively younger athletes, hardly any late maturing athletes were present. These findings revealed that relatively younger athletes seemed to only have a chance for selection if they were early maturing, whereas relatively older athletes had an increased likelihood for selection independent of their biological maturity status. In the future, the relative age and the biological maturity status should be considered in the talent development system for various types of winter sport, to contribute to more fairness and to not discriminate against relatively younger and less mature athletes. Key points The relative age strongly influenced the participation rate at the 7th ICG in 2016. A highly significant RAE was present among male and female participants and among athletes of all three groups of sport

  3. Toward A Feminist Transformation of the Academy: III. Proceedings of the Annual GLCA Women's Studies Conference (7th, November 6-8, 1981).

    ERIC Educational Resources Information Center

    Reed, Beth, Ed.; And Others

    Ten selected papers and a panel discussion are included in these conference proceedings. The first paper is entitled "The Emergence of Women in Twentieth-Century Chilean History and Literature" (Caroline Richards). The second paper is "Attitudes Toward Gender in Two Cultures: Puerto Rico and the United States" (Margaret Berrio,…

  4. Toward A Feminist Transformation of the Academy: III. Proceedings of the Annual GLCA Women's Studies Conference (7th, November 6-8, 1981).

    ERIC Educational Resources Information Center

    Reed, Beth, Ed.; And Others

    Ten selected papers and a panel discussion are included in these conference proceedings. The first paper is entitled "The Emergence of Women in Twentieth-Century Chilean History and Literature" (Caroline Richards). The second paper is "Attitudes Toward Gender in Two Cultures: Puerto Rico and the United States" (Margaret Berrio,…

  5. The Role of a Relative Age Effect in the 7(th) International Children's Winter Games 2016 and the Influence of Biological Maturity Status on Selection.

    PubMed

    Müller, Lisa; Hildebrandt, Carolin; Raschner, Christian

    2017-06-01

    The aim of this study was to analyse the role of a relative age effect (RAE) and to investigate the influence of biological maturity status on the RAE at the 7(th) International Children`s Winter Games. The birth dates of all 572 participants (365 males, 207 females) were analysed, and the biological maturity status of 384 athletes (243 males, 141 females) was assessed by the age at peak height velocity (APHV) method. A RAE was present in the total sample (χ(2) = 67.81; p < 0.001), and among both male (χ(2) = 49.02; p < 0.001) and female athletes (χ(2) = 37.00; p < 0.001) as well as for strength- (χ(2) = 56.46; p < 0.001), endurance- (χ(2) = 20.48; p = 0.039) and technique-related types of sports (χ(2) = 20.48; p = 0.041). No significant differences in biological maturity status were present between the male athletes of single relative age quarters. Among the female athletes a significant difference was present (F = 5.94, p < 0.001); relatively younger female athletes had significantly lower values in the APHV, which indicated that they were maturing earlier. However, when dividing the athletes into normal, early and late maturing athletes, it could be seen that among the relatively younger athletes, hardly any late maturing athletes were present. These findings revealed that relatively younger athletes seemed to only have a chance for selection if they were early maturing, whereas relatively older athletes had an increased likelihood for selection independent of their biological maturity status. In the future, the relative age and the biological maturity status should be considered in the talent development system for various types of winter sport, to contribute to more fairness and to not discriminate against relatively younger and less mature athletes.

  6. Trends of violence among 7th, 8th and 9th grade students in the state of Lara, Venezuela: The Global School Health Survey 2004 and 2008

    PubMed Central

    2011-01-01

    Background Violence by young people is one of the most visible forms of violence and contributes greatly to the global burden of premature death, injury and disability. Methods The Global School-based Student Health Survey (GSHS), State of Lara, Venezuela (GSHS-Lara) is a school-based surveillance system. It comprises a repeated, cross-sectional, self-administered survey drawn from a representative sample of 7th to 9th grade students, performed in the school years 2003-2004 (GSHS-Lara 2004) and 2007-2008 (GSHS-Lara 2008). It explores, among other things, a general violence indicator such as school absenteeism due to feeling unsafe at school or on the way to or from school for any reason; and more specific indicators of violence such as robbery, bullying, physical fights and use of weapons, as well as exposure to lectures on how to prevent violence. Results are given in terms of prevalence percentage. Results Absenteeism doubled between the two study periods (10.8% to 20.8%). The number of students that were a victim of robbery remained high and without change both outside (14.2% and 14.8%) and inside school (21.7% and 22.0%). The number of victims of bullying was high and increasing (33.4% and 43.6%). Bullying associated with being physically attacked decreased (18.5% to 14.3%). Physical attacks without active participation and not associated with bullying were frequent (21.5%). Physical fighting with active participation prevalence remained high and without change (27.5% and 28.2%). Carrying a weapon almost doubled (4.3% to 7.1%). Less than 65% reported classes for violence prevention. Conclusions The GSHS-Lara shows that violence is an important public health problem that needs to be addressed by the community and its authorities. PMID:22958602

  7. Novel C617Y mutation in the 7th transmembrane segment of luteinizing hormone/choriogonadotropin receptor in a Japanese boy with peripheral precocious puberty.

    PubMed

    Nagasaki, Keisuke; Katsumata, Noriyuki; Ogawa, Yohei; Kikuchi, Toru; Uchiyama, Makoto

    2010-01-01

    Testotoxicosis, also known as familial male-limited precocious puberty, is an autosomal dominant form of gonadotropin-independent precocious puberty caused by heterozygous constitutively activating mutations of the LHCGR gene encoding the luteinizing hormone/choriogonadotropin receptor (LH/CGR). The patient is an 8-year-old boy who started to develop pubic hair and penile enlargement at 6 years of age. The patient had elevated serum testosterone levels, but initially exhibited a prepubertal response of gonadotropins to GnRH, which was followed by central activation of the hypothalamo-pituitary-gonadal axis. The father reported having experienced precocious puberty, and is 158 cm tall. There is no history of short stature and precocious puberty in the family except for the father. The LHCGR gene was analyzed by direct DNA sequencing of amplified PCR products from the patient and his parents. The wild-type and mutant LH/CGRs were transiently expressed in COS-1 cells and cAMP levels in the cells were determined with or without hCG stimulation. Genetic analysis revealed a novel C617Y mutation of the LHCGR gene in the patient and his mother, while his father had no mutations. Functional expression study demonstrated around 15% increase in the basal intracellular cAMP level in cells expressing the mutant LH/CGR compared with that in cells expressing the wild-type receptor. We have reported the first missense C617Y mutation located in the 7th transmembrane segment of LH/CGR causing testotoxicosis. The modest phenotype of our patient may be explained, at least in part, by the modest increase in the intracellular cAMP level caused by the C617Y mutation.

  8. Cornelia de Lange syndrome and molecular implications of the cohesin complex: Abstracts from the 7th biennial scientific and educational symposium 2016.

    PubMed

    Kline, Antonie D; Krantz, Ian D; Deardorff, Matthew A; Shirahige, Katsuhiko; Dorsett, Dale; Gerton, Jennifer L; Wu, Meng; Mehta, Devanshi; Mills, Jason A; Carrico, Cheri S; Noon, Sarah; Herrera, Pamela S; Horsfield, Julia A; Bettale, Chiara; Morgan, Jeremy; Huisman, Sylvia A; Moss, Jo; McCleery, Joseph; Grados, Marco; Hansen, Blake D; Srivastava, Siddharth; Taylor-Snell, Emily; Kerr, Lynne M; Katz, Olivia; Calof, Anne L; Musio, Antonio; Egense, Alena; Haaland, Richard E

    2017-05-01

    Cornelia de Lange Syndrome (CdLS) is due to mutations in the genes for the structural and regulatory proteins that make up the cohesin complex, and is considered a cohesinopathy disorder or, more recently, a transcriptomopathy. New phenotypes have been recognized in this expanding field. There are multiple clinical issues facing individuals with all forms of CdLS, particularly in the neurodevelopmental system, but also gastrointestinal, cardiac, and musculoskeletal. Aspects of developmental and cell biology have found common endpoints in the biology of the cohesin complex, with improved understanding of the mechanisms, easier diagnostic tests, and the possibility of potential therapeutics, all major clinical implications for the individual with CdLS. The following abstracts are the presentations from the 7th Cornelia de Lange Syndrome Scientific and Educational Symposium, June 22-23, 2016, in Orlando, FL, in conjunction with the Cornelia de Lange Syndrome Foundation National Meeting. In addition to the scientific and clinical discussions, there were talks related to practical aspects of behavior including autism, transitions, communication, access to medical care, and databases. At the end of the symposium, a panel was held, which included several parents, affected individuals and genetic counselors, and discussed the greatest challenges in life and how this information can assist in guiding future research. The Research Committee of the CdLS Foundation organizes this meeting, reviews, and accepts abstracts, and subsequently disseminates the information to the families through members of the Clinical Advisory Board and publications. AMA CME credits were provided by Greater Baltimore Medical Center, Baltimore, MD. © 2017 Wiley Periodicals, Inc.

  9. Report of the 7th meeting on Evaluation of Pandemic Influenza Vaccines in Clinical Trials, World Health Organization, Geneva, 17-18 February 2011.

    PubMed

    Girard, Marc P; Katz, Jacqueline M; Pervikov, Yuri; Hombach, Joachim; Tam, John S

    2011-10-13

    On February 17-18, 2011, the World Health Organization convened the 7th meeting on "The Evaluation of Pandemic Influenza Vaccines in Clinical Trials" to review the progress made on pandemic A (H1N1) 2009 vaccines and the evaluation of their effectiveness in the field, especially in children less than 3 years of age and in pregnant women. Other topics to be addressed included a comparison of egg- and cell culture-based influenza vaccines, technical issues related to vaccine strain development and vaccine potency, and the status of development of prototype influenza vaccines using new technologies. Pandemic A (H1N1) vaccines were safe in young children, pregnant women and immunocompromized individuals. Overall effectiveness of inactivated A (H1N1) vaccines for all ages was found to vary between 72% and 100% in different countries and with different vaccine preparations. Effectiveness of pandemic A (H1N1) 2009 live attenuated vaccine was estimated to be approximately 80% in pediatric populations in the USA. A single dose of inactivated vaccine adjuvanted with AS03, MF59 or AF03 induced protective immunity in young children and pregnant women. However, unadjuvanted vaccines as well as low dose adjuvanted vaccines (1.9 μg HA) required two doses to elicit protective antibody levels in these populations. Clinical trials of influenza vaccines developed using new technologies showed they were well tolerated and induced antibody and/or T cell immune responses to viral proteins. Further studies are warranted to validate novel immunological criteria for evaluation and licensing of such new influenza vaccine concepts. On the regulatory side, work should be undertaken to harmonize the results of serological tests used to evaluate the immunogenicity of traditional influenza vaccines.

  10. [Evaluation of the value of 7th editions of UICC-AJCC esophageal and gastric cancer TNM staging systems for prognostic prediction of adenocarcinoma of esophagogastric junction (Siewert type II)].

    PubMed

    Shi, Guidong; Luo, Zhilin; Fu, Maoyong; Tian, Dong; Zhang, Lin; Zhang, Keping

    2014-12-23

    To compare the value of applicability of the 7th edition of UICC-AJCC esophageal and gastric cancer TNM staging system in the prognostic prediction of adenocarcinoma of esophagogastric junction (EGJ). During June 1, 2007 through Dec. 31, 2010, a total of 199 patients with adenocarcinoma of esophagogastric junction (Siewert type II) underwent R0-intent resection from June 1, 2007 to Dec 31, 2010 in our hospital. Their clinicopathological and survival data were retrospectively analyzed with Kaplan-Meier and Cox regression models. They were restaged according to the 7th edition of UICC/AJCC TNM stage systems for esophageal adenocarcinoma and gastric cancer, respectively. Then the likelihood ratio chi-square test related to the Cox regression model and Akaike information criterion (AIC) were used for measuring goodness of fit for both staging systems. 199 patients with Siewert type II esophagogastric junction adenocarcinoma were identified in this study. Out of them, there were 162 males and 37 females. Their age range was from 38 to 79 years, with a median age of 62 years. 176 cases underwent transthoracic surgery, and other 23 cases underwent transabdominal surgery. TNM-EC and TNM-GC classified 4 patients to stage T1, 39 to T2, 139 to T3, and 17 to T4a, respectively, and classified 76 patients to stage N0, 58 to N1, 49 to N2, 16 to N3, respectively. The median follow-up period was 30 months. The 1-, 3-, and 5-year survival rates were 95.0%, 52.7% and 39.2%, respectively. Univariate analysis indicated that age at surgery (P = 0.009), surgical approach (P = 0.002), cell differentiation (P = 0.030), preoperative co-morbidity implications (P = 0.026), depth of tumor invasion (P < 0.001) and number of metastatic lymph nodes (P < 0.001) were significantly influencing factors of postoperative overall survival. Multivariate analysis showed that the independent prognostic factors for adenocarcinoma of esophagogastric junction were only T stage, N stage and preoperative co

  11. The Not-so-Dark Ages: ecology for human growth in medieval and early twentieth century Portugal as inferred from skeletal growth profiles.

    PubMed

    Cardoso, Hugo F V; Garcia, Susana

    2009-02-01

    This study attempts to address the issue of relative living standards in Portuguese medieval and early 20th century periods. Since the growth of children provides a good measure of environmental quality for the overall population, the skeletal growth profiles of medieval Leiria and early 20th century Lisbon were compared. Results show that growth in femur length of medieval children did not differ significantly from that of early 20th century children, but after puberty medieval adolescents seem to have recovered, as they have significantly longer femora as adults. This is suggestive of greater potential for catch-up growth in medieval adolescents. We suggest that this results from distinct child labor practices, which impact differentially on the growth of Leiria and Lisbon adolescents. Work for medieval children and adolescents were related to family activities, and care and attention were provided by family members. Conversely, in early 20th century Lisbon children were more often sent to factories at around 12 years of age as an extra source of family income, where they were exploited for their labor. Since medieval and early 20th century children were stunted at an early age, greater potential for catch-up growth in medieval adolescents results from exhausting work being added to modern adolescent's burdens of disease and poor diet, when they entered the labor market. Although early 20th century Lisbon did not differ in overall unfavorable living conditions from medieval Leiria, after puberty different child labor practices may have placed modern adolescents at greater risk of undernutrition and poor growth. 2008 Wiley-Liss, Inc.

  12. Nineteenth-Century American and British Poets on Columbus: A Twentieth-Century View.

    ERIC Educational Resources Information Center

    Gorman, Anita G.

    In the 19th century alone, Christopher Columbus was the subject of hundreds of poems that rarely questioned his voyage, his methods, or his place in human history. However, the scholarly work and political realities of the 20th century have undermined the noble, heroic visions conveyed by the poets. Modern readers/students have a dual duty to…

  13. Commentary on “Toxicity Testing in the 21st Century: Implications for Human Health Risk Assessment” by Krewski et al.

    EPA Science Inventory

    The main goal of Toxicity Testing in the 21st Century: A Vision and A Strategy(1) is to provide a practical means of evaluating the heath risks of chemicals. The vision is in stark contrast to the current situation, where the focus on apical testing in vivo is too expensive and t...

  14. Music, Education and Community in Nineteenth-Century Kansas: Euterpe, Tonnies, and the Academy on the Plains. Country School Legacy: Humanities on the Frontier.

    ERIC Educational Resources Information Center

    Haack, Paul A.; Heller, George N.

    Music, education, and community and the interactions among these three factors in Kansas during the 19th century offer an opportunity to study the role and function of music education in a sociocultural context. From 1824-1899, 16 Catholic missions were opened in Kansas for American Indians. These schools used music as an adjunct to academic…

  15. Commentary on “Toxicity Testing in the 21st Century: Implications for Human Health Risk Assessment” by Krewski et al.

    EPA Science Inventory

    The main goal of Toxicity Testing in the 21st Century: A Vision and A Strategy(1) is to provide a practical means of evaluating the heath risks of chemicals. The vision is in stark contrast to the current situation, where the focus on apical testing in vivo is too expensive and t...

  16. "More than Measurable Human Products": Catholic Educators' Responses to the Educational Measurement Movement in the First Half of the 20th Century

    ERIC Educational Resources Information Center

    Ryan, Ann Marie

    2009-01-01

    During the first half of the 20th century, Catholic educators in the United States used theological arguments both to resist and embrace the progressive educational reform effort of educational measurement. The significant expansion of Catholic schooling and the increased number of students attending them, along with increased state oversight, led…

  17. Charting Russia's Future in the Post-Soviet Era. Teacher's Resource Book [and Student Guidebook]. Public Policy Debate in the Classroom: Choices for the 21st Century Education Project. 7th Edition.

    ERIC Educational Resources Information Center

    Brown Univ., Providence, RI. Thomas J. Watson, Jr. Inst. for International Studies.

    This teacher resource text and student text are part of a continuing series on current and historical international issues, placing special emphasis on the importance of educating students in their participatory role as citizens. It examines the debate on Russia's identity from a Russian perspective in the areas of economic development, political…

  18. Process evaluation for a school-based physical activity intervention for 6th- and 7th-grade boys: reach, dose, and fidelity.

    PubMed

    Robbins, Lorraine B; Pfeiffer, Karin Allor; Wesolek, Stacey M; Lo, Yun-Jia

    2014-02-01

    The purpose was to evaluate the reach, dose, and fidelity of Guys Only Activity for Life (G.O.A.L.), a 7-week pilot intervention conducted from February to March 2011 to increase 6th and 7th grade boys' moderate-to-vigorous physical activity (MVPA). One middle school was randomly assigned to the G.O.A.L. intervention and another from the same urban school district in the Midwestern U.S. to a comparison condition. Thirty boys, ages 10-14 years, participated in each school. The intervention, guided by the Health Promotion Model (HPM) and Self-Determination Theory (SDT), consisted of a 90-min after-school physical activity club 4 days/week and one motivational interviewing session with a registered (school) nurse. Data were gathered via attendance records, club observations, heart rate monitors, audio-taping of motivational interviewing sessions, and surveys. On average boys attended the club 2.11 days/week (SD=.86). A trained independent process evaluator reported that the physical activity club instructors provided the boys with the opportunity for a mean of 25.8 min/day of MVPA. Using a four-point Likert scale (1=disagree a lot; 4=agree a lot), the process evaluator perceived that the club was delivered with high fidelity and adherence to the underlying theories (M=3.48; SD=0.39). Sessions with the nurse lasted an average of 13 min, 29 s. All boys attended. Two trained independent coders indicated that the nurse demonstrated at least beginning proficiency for all tasks associated with motivational interviewing, with the exception of using sufficient open- as opposed to closed-ended questions and reflections compared to questions. Fidelity related to session delivery and adherence to the theories was high (M=3.83; SD=0.19). The process evaluation data indicated that strategies are needed to increase attendance and boys' MVPA during the club time. Copyright © 2013 Elsevier Ltd. All rights reserved.

  19. A Multi-Layer Phoswich Radioxenon Detection System (7th Qtr Report), Reporting Period 10/01/07 - 12/31/07

    SciTech Connect

    David M. Hamby

    2008-01-29

    Description of activities conducted this report period: (1) Electronics Development--To improve the overall performance of the two-channel digital pulse processor (DPP2), the PCB has been redesigned and the new printed board is now under assembly. The system is enhanced with two new fast ADCs from Analog Devices (AD9230-250), each with a sampling rate of 250 MHz and a resolution of 12 bits. The data bus uses a high performance Low Voltage Differential Signaling (LVDS) standard. The offset and gain of each channel are separately controlled digitally by the GUI software. (2) GUI Software Development--A GUI is being developed using the Python programming language. All functions from the preceding MATLAB code have been re-implemented including basic waveform readout, pulse shape discrimination, and plotting of energy spectra. In addition, the GUI can be used to control sampling runs based on the number of pulses captured, either in real or live time. Calibration coefficients and pulse shape discrimination boundaries can be changed on the fly so that the detector may be characterized experimentally. Plots generated by the GUI can be exported as graphic data. At present, the software has only been tested using one channel, pending availability of the new DPP board (DPP2). However, the functions have been written to allow easy expansion to two channels. (3) Light Collection Modeling--The XEPHWICH design has been modeled to determine its light capture efficiency. Research in the 7th quarter includes additional simulations representing significant increase in data resolution, well over an order of magnitude greater than previous simulations. The final data set represents approximately 11 billion visible photons divided equally among 110 thousand data points. A laboratory experiment is being designed and executed to experimentally determine light capture efficiency as a function of position within the scintillators. (4) Radioxenon Fission Source--We have designed and

  20. Temperature reconstruction for the Tibetan Plateau in the past 2ka years from ice cores and human documentary record

    NASA Astrophysics Data System (ADS)

    Yang, X.

    2011-12-01

    Temperature variation in the past 2000 years on the plateau is reconstructed from Puruogangri ice core d18O, and compared before compositing with other three ice core records as the Dunde ice core (northeast Plateau), Guliya ice core (northwest Plateau) and Dasuopu ice core (south Plateau). The comparison reveals the synchroneity of large-scale climate events, and the composition highlights the warming in the 7th century and 12-13th centuries, and the cold in the 19th century. We searched for historical documentary about Tibet since A.D. 620, extracting record of human activities and social development directly determined or indirectly influenced by climate, and categorizing it into five aspects as basic resources, economic development, military strength, national coherence, and cultural and religious development, to quantify Tibetan development till A.D. 1900. Curve based upon the sum of the five aspects shows Tibetan national strength variation in the past 2000 years. The composited ice core record and Tibetan national strength variation shows consistency, especially during the Songtsen Gampo reign, medieval warm period and the 19th century cold period, thus suggesting the dominative role of climate change in Tibetan civilization before modern ages, as well as proposing the potential application of historical record in paleoclimate reconstruction on the Tibetan Plateau.

  1. Milton and the ’New Philosophy’: An Historical-Literary Exploration of the Relationship between Science and the Humanities in the 17th Century.

    DTIC Science & Technology

    1983-06-20

    University of Texas Press, 1953. Cowley, Abraham. Selected Poetry and Prose. Ed. James G. Taaffe. New York: * - Appleton-Century-Crofts, 1970. Debus, Allen...Empiricism 25 *The Scientific Propagandism of Francis Bacon 38 The Great Contention 59 The Figure of Milton Biography 73 Of Education 80 Milton’s Epic Poetry ...Virginia State Department of Education at Mary Baldwin College in Staunton. Laced between my exposure to astronomy and political scienct [not to mention the

  2. Management of Medical Termination of Pregnancy (MToP) up until the 7th week of gestation in the Czech Republic.

    PubMed

    Slunska, P; Hanacek, J; Fanta, M; Sehnal, B; Gerychová, R; Hola, A; Zdenkova, A; Neumannová, H; Dziakova, M; Lubusky, M

    2017-01-01

    In the Czech Republic (CR), it is possible, to carry out Medical Termination of Pregnancy (MToP) in the 1st trimester since June 2014, in case a woman submits a written request for it and in case the ultrasound examination confirms an intrauterine singleton prosperous pregnancy, between day 42 and 49 of gestation, crown-rump length (CRL) of the embryo 2-9 mm. The aim of the study is to analyze the management of MToP up until the 7th week of gestation in five centres in the CR. Multicenter cohort (prospective) study. Department of Obstetrics and Gynecology, Palacky University Olomouc, Faculty of Medicine and Dentistry, University Hospital Olomouc; The Institute for the Care of Mother and Child, Charles University in Prague, Third faculty of Medicine; Department of Gynecology and Obstetrics, Charles University in Prague, First faculty of Medicine, General University Hospital in Prague; Department of Gynecology and Obstetrics, Charles University in Prague, First faculty of Medicine, Hospital Na Bulovce, Prague; Department of Gynecology and Obstetrics, Masaryk University, Faculty of Medicine, University Hospital Brno. In 2014-2016, a total of 1820 pregnant women requested MToP. The diagnosis of an intrauterine singleton prosperous pregnancy was set by transvaginal ultrasound, CRL 2-9 mm. MToP was carried out by combination of mifepristone (600 mg orally) and misoprostol (400 mcg orally) within 48 hours. MToP follow up (exclusion of ongoing pregnancy) after 2-3 weeks was carried out by transvaginal ultrasound as well. In 11.0% of women (201/1820) who requested MToP, CRL > 9 mm, unprosperous, multiple or ectopic pregnancy was diagnosed. In the remaining 1619 women MToP was carried out, but in 221 cases (13.7%) at least one additional pre-first visit was needed before the diagnosis of intrauterine singleton prosperous pregnancy CRL 2-9 mm could be established, in 19 cases (1.2%) two pre-first visits and in 5 cases (0.3%) even three. Gestational age was 42-49 days (average

  3. [Management of Medical Termination of Pregnancy (MToP) up until the 7th week of gestation in the Czech Republic].

    PubMed

    Slunska, P; Hanacek, J; Fanta, M; Sehnal, B; Gerychová, R; Hola, A; Zdenkova, A; Neumannová, H; Dziakova, M; Lubusky, M

    2017-01-01

    In the Czech Republic (CR), it is possible, to carry out Medical Termination of Pregnancy (MToP) in the 1st trimester since June 2014, in case a woman submits a written request for it and in case the ultrasound examination confirms an intrauterine singleton prosperous pregnancy, between day 42 and 49 of gestation, crown-rump length (CRL) of the embryo 2-9 mm. The aim of the study is to analyze the management of MToP up until the 7th week of gestation in five centres in the CR. Multicenter cohort (prospective) study. Department of Obstetrics and Gynecology, Palacky University Olomouc, Faculty of Medicine and Dentistry, University Hospital Olomouc; The Institute for the Care of Mother and Child, Charles University in Prague, Third faculty of Medicine; Department of Gynecology and Obstetrics, Charles University in Prague, First faculty of Medicine, General University Hospital in Prague; Department of Gynecology and Obstetrics, Charles University in Prague, First faculty of Medicine, Hospital Na Bulovce, Prague; Department of Gynecology and Obstetrics, Masaryk University, Faculty of Medicine, University Hospital Brno. In 2014-2016, a total of 1820 pregnant women requested MToP. The diagnosis of an intrauterine singleton prosperous pregnancy was set by transvaginal ultrasound, CRL 2-9 mm. MToP was carried out by combination of mifepristone (600 mg orally) and misoprostol (400 mcg orally) within 48 hours. MToP follow up (exclusion of ongoing pregnancy) after 2-3 weeks was carried out by transvaginal ultrasound as well. In 11.0% of women (201/1820) who requested MToP, CRL > 9 mm, unprosperous, multiple or ectopic pregnancy was diagnosed. In the remaining 1619 women MToP was carried out, but in 221 cases (13.7%) at least one additional pre-first visit was needed before the diagnosis of intrauterine singleton prosperous pregnancy CRL 2-9 mm could be established, in 19 cases (1.2%) two pre-first visits and in 5 cases (0.3%) even three. Gestational age was 42-49 days (average

  4. EDITORIAL: The 7th International Workshop on Micro and Nanotechnologies for Power Generation and Energy Conversion Applications (PowerMEMS 2007)

    NASA Astrophysics Data System (ADS)

    Hebling, C.; Woias, P.

    2008-10-01

    This special issue of Journal of Micromechanics and Microengineering (JMM) contains a selection of papers from the 7th International Workshop on Micro and Nanotechnologies for Power Generation and Energy Conversion (PowerMEMS 2007). The workshop was held in Freiburg, Germany on 27-29 November 2007 under the joint organization of the Fraunhofer Institute for Solar Energy Systems (FhG-ISE), Freiburg and the Department of Microsystems Engineering (IMTEK) of the Albert-Ludwig-University of Freiburg. PowerMEMS 2007 continues a series of workshops initiated in 2000 in Japan to create an annual discussion forum in the emerging field of micro energy technology. With a single exception in 2001, the workshop has continued as an annual meeting ever since, with a continuous increase in the number of presentations and participants. The program of PowerMEMS 2007 was composed of 2 invited talks, 25 oral talks and 61 poster presentations. From these 88 presentations 16 have been selected for this special issue. It was at the end of 1959 when the Caltech physicist Richard Feynman gave his famous lecture entitled 'There Is Plenty of Room at the Bottom' in which he discussed the possibilities of miniaturization for both storage capacity ('Encyclopaedia Britannica on the head of a pin') as well as micro machining ('rearranging the atoms'), although there were absolutely no technological possibilities in sight for an adequate realization of such ideas. Now, nearly 50 years later, we not only have incredible knowledge about the nanoworld, but even more we are now able to generate microelectromechanical devices which, next to their electronic properties, can integrate physical and analytical functions. Today, Feynman might easily have added a second lecture entitled 'There is Plenty of Energy at the Bottom'. Micro energy technology has seen a tremendous rise in MEMS and material sciences and is regarded today as one of their hot topics. Also, there are more and more companies in this

  5. 21st Century Scholars

    ERIC Educational Resources Information Center

    Clark, Terrence

    2009-01-01

    Bethpage Union Free School District in New York is a high-performing district by almost any current accountability measure. Yet administrators and teachers worried that they were not doing enough to prepare their students as critical thinkers for the 21st century. Inspired by the curriculum framework of the Partnership for 21st Century Skills, the…

  6. 21st Century Scholars

    ERIC Educational Resources Information Center

    Clark, Terrence

    2009-01-01

    Bethpage Union Free School District in New York is a high-performing district by almost any current accountability measure. Yet administrators and teachers worried that they were not doing enough to prepare their students as critical thinkers for the 21st century. Inspired by the curriculum framework of the Partnership for 21st Century Skills, the…

  7. PREFACE PASREG: The 7th International Workshop on the Processing and Applications of Superconducting (RE)BCO Large Grain Materials (Washington DC, 29-31 July 2010) PASREG: The 7th International Workshop on the Processing and Applications of Superconducting (RE)BCO Large Grain Materials (Washington DC, 29-31 July 2010)

    NASA Astrophysics Data System (ADS)

    Freyhardt, Herbert; Cardwell, David; Strasik, Mike

    2010-12-01

    Large grain, (RE)BCO bulk superconductors fabricated by top seeded melt growth (TSMG) are able to generate large magnetic fields compared to conventional, iron-based permanent magnets. Following 20 years of development, these materials are now beginning to realize their considerable potential for a variety of engineering applications such as magnetic separators, flywheel energy storage and magnetic bearings. MgB2 has also continued to emerge as a potentially important bulk superconducting material for engineering applications below 20 K due to its lack of granularity and the ease with which complex shapes of this material can be fabricated. This issue of Superconductor Science and Technology contains a selection of papers presented at the 7th International Workshop on the Processing and Applications of Superconducting (RE)BCO Large Grain Materials, including MgB2, held 29th-31sy July 2010 at the Omni Shoreham Hotel, Washington DC, USA, to report progress made in this field in the previous three year period. The workshop followed those held previously in Cambridge, UK (1997), Morioka, Japan (1999), Seattle, USA (2001), Jena, Germany (2003), Tokyo, Japan (2005) and again in Cambridge, UK (2007). The scope of the seventh PASREG workshop was extended to include processing and characterization aspects of the broader spectrum of bulk high temperature superconducting (HTS) materials, including melt-cast Bi-HTS and bulk MgB2, recent developments in the field and innovative applications of bulk HTS. A total of 38 papers were presented at this workshop, of which 30 were presented in oral form and 8 were presented as posters. The organizers wish to acknowledge the efforts of Sue Butler of the University of Houston for her local organization of the workshop. The eighth PASREG workshop will be held in Taiwan in the summer of 2012.

  8. Theoretical Bridge-Building: The Career Development Project for the 21st Century Meets the New Era of Human Resource Development

    ERIC Educational Resources Information Center

    Cameron, Roslyn

    2009-01-01

    There are theoretical and disciplinary field links between career development and human resource development, however interdisciplinary dialogue between the two fields has been essentially limited to one-way dialogue. This one-way dialogue occurs from within the human resource development field, due to the explicit inclusion of career development…

  9. Theoretical Bridge-Building: The Career Development Project for the 21st Century Meets the New Era of Human Resource Development

    ERIC Educational Resources Information Center

    Cameron, Roslyn

    2009-01-01

    There are theoretical and disciplinary field links between career development and human resource development, however interdisciplinary dialogue between the two fields has been essentially limited to one-way dialogue. This one-way dialogue occurs from within the human resource development field, due to the explicit inclusion of career development…

  10. The Coverage of Human Evolution in High School Biology Textbooks in the 20th Century and in Current State Science Standards

    NASA Astrophysics Data System (ADS)

    Skoog, Gerald

    Efforts to eliminate or neutralize the coverage of evolution in high school biology textbooks in the United States have persisted with varying degrees of intensity and success since the 1920s. In particular, the coverage of human evolution has been impacted by these efforts. Evidence of the success of these efforts can be chronicled by the emphasis given to human evolution in secondary biology textbooks historically and in the current state science standards. Prior to the 1960s, biology textbooks provided little emphasis to human evolution. In the 1970s and early 1980s textbooks reduced the coverage of human evolution. However, in the 1990s the coverage became quite comprehensive again. In 2004, the state science frameworks of only three states had standards concerned with human evolution.

  11. [Evaluation of American Joint Commission on Cancer(8(th) edition) and Japanese Pancreas Society(7(th) edition)changes for T and N staging in patients with pancreatic adenocarcinoma].

    PubMed

    Yang, Y M

    2017-01-01

    Accurate staging for cancer is the basis for clinical practice, individualized treatment strategy, and prognosis determination.Recently, the T and N staging systems for pancreatic adenocarcinoma were updated by both American Joint Commission on Cancer(AJCC)8(th) edition and Japanese Pancreas Society 7(th) edition, in which more objective parameters were applied.When a large number of patients within the test set were staged, AJCC 8(th) edition has showed more reproducible and helped to predict the patient prognosis more accurately.

  12. The Hospital Microbiome Project: Meeting Report for the 1st Hospital Microbiome Project Workshop on sampling design and building science measurements, Chicago, USA, June 7th-8th 2012.

    PubMed

    Smith, Daniel; Alverdy, John; An, Gary; Coleman, Maureen; Garcia-Houchins, Sylvia; Green, Jessica; Keegan, Kevin; Kelley, Scott T; Kirkup, Benjamin C; Kociolek, Larry; Levin, Hal; Landon, Emily; Olsiewski, Paula; Knight, Rob; Siegel, Jeffrey; Weber, Stephen; Gilbert, Jack

    2013-04-15

    This report details the outcome of the 1st Hospital Microbiome Project workshop held on June 7th-8th, 2012 at the University of Chicago, USA. The workshop was arranged to determine the most appropriate sampling strategy and approach to building science measurement to characterize the development of a microbial community within a new hospital pavilion being built at the University of Chicago Medical Center. The workshop made several recommendations and led to the development of a full proposal to the Alfred P. Sloan Foundation as well as to the creation of the Hospital Microbiome Consortium.

  13. Quantitative analysis of human remains from 18(th)-19(th) centuries using X-ray fluorescence techniques: The mysterious high content of mercury in hair.

    PubMed

    Pessanha, Sofia; Carvalho, Marta; Carvalho, Maria Luisa; Dias, António

    2016-01-01

    In this work, we report the unusual concentration of mercury in the hair of an individual buried in the 18th to mid-19th centuries and the comparison with the elemental composition of other remains from the same individual. Two energy dispersive X-ray fluorescence (EDXRF) setups, one with tri-axial geometry and the second one with micro-beam capabilities and a vacuum system, for light elements detection, have been used. Quantitative evaluation of the obtained spectra were made by fundamental parameters and winAXIL program by compare mode method. The levels of Hg in the hair of buried samples presented a concentration over 5% (w/w), a significantly lower presence of this element in the cranium, and no Hg in the remaining organs. Furthermore, there was no evidence of Hg in the burial soil, which has been also analyzed. From this result, we could conclude that the possibility of post-mortem contamination from the burial surroundings is very unlikely. The obtained results are indicative of the apparent use of a mercury-based compound for medical purposes, most likely lice infestation. Copyright © 2015 Elsevier GmbH. All rights reserved.

  14. Martian weather and climate in the 21st century

    SciTech Connect

    Zurek, R.W.

    1990-01-01

    The historical interest in the weather and climate of Mars and current understanding of aspects of the present climate are addressed. Scientific research into the weather and climate of Mars in the next century is examined. The impact of the Martian weather of the 21st century on humans that may then be inhabiting the planet is considered. 8 refs.

  15. New archeointensity data from French Early Medieval pottery production (6th-10th century AD). Tracing 1500 years of geomagnetic field intensity variations in Western Europe

    NASA Astrophysics Data System (ADS)

    Genevey, Agnès; Gallet, Yves; Jesset, Sébastien; Thébault, Erwan; Bouillon, Jérôme; Lefèvre, Annie; Le Goff, Maxime

    2016-08-01

    Nineteen new archeointensity results were obtained from the analysis of groups of French pottery fragments dated to the Early Middle Ages (6th to 10th centuries AD). They are from several medieval ceramic production sites, excavated mainly in Saran (Central France), and their precise dating was established based on typo-chronological characteristics. Intensity measurements were performed using the Triaxe protocol, which takes into account the effects on the intensity determinations of both thermoremanent magnetization anisotropy and cooling rate. Intensity analyses were also carried out on modern pottery produced at Saran during an experimental firing. The results show very good agreement with the geomagnetic field intensity directly measured inside and around the kiln, thus reasserting the reliability of the Triaxe protocol and the relevance of the quality criteria used. They further demonstrate the potential of the Saran pottery production for archeomagnetism. The new archeointensity results allow a precise and coherent description of the geomagnetic field intensity variations in Western Europe during the Early Medieval period, which was until now poorly documented. They show a significant increase in intensity during the 6th century AD, high intensity values from the 7th to the 9th century, with a minimum of small amplitude at the transition between the 7th and the 8th centuries and finally an important decrease until the beginning of the 11th century. Together with published intensity results available within a radius of 700 km around Paris, the new data were used to compute a master curve of the Western European geomagnetic intensity variations over the past 1500 years. This curve clearly exhibits five intensity maxima: at the transition between the 6th and 7th century AD, at the middle of the 9th century, during the 12th century, in the second part of the 14th century and at the very beginning of the 17th century AD. Some of these peaks are smoothed, or

  16. Climate, people, fire and vegetation: new insights into vegetation dynamics in the Eastern Mediterranean since the 1st century AD

    NASA Astrophysics Data System (ADS)

    Bakker, J.; Paulissen, E.; Kaniewski, D.; Poblome, J.; De Laet, V.; Verstraeten, G.; Waelkens, M.

    2013-01-01

    Anatolia forms a bridge between Europe, Africa and Asia and is influenced by all three continents in terms of climate, vegetation and human civilisation. Unfortunately, well-dated palynological records focussing on the period from the end of the classical Roman period until subrecent times are rare for Anatolia and completely absent for southwest Turkey, resulting in a lacuna in knowledge concerning the interactions of climatic change, human impact, and environmental change in this important region. Two well-dated palaeoecological records from the Western Taurus Mountains, Turkey, provide a first relatively detailed record of vegetation dynamics from late Roman times until the present in SW Turkey. Combining pollen, non-pollen palynomorphs, charcoal, sedimentological, archaeological data, and newly developed multivariate numerical analyses allows for the disentangling of climatic and anthropogenic influences on vegetation change. Results show changes in both the regional pollen signal as well as local soil sediment characteristics match shifts in regional climatic conditions. Both climatic as well as anthropogenic change had a strong influence on vegetation dynamics and land use. A moist environmental trend during the late-3rd century caused an increase in marshes and wetlands in the moister valley floors, limiting possibilities for intensive crop cultivation at such locations. A mid-7th century shift to pastoralism coincided with a climatic deterioration as well as the start of Arab incursions into the region, the former driving the way in which the vegetation developed afterwards. Resurgence in agriculture was observed in the study during the mid-10th century AD, coinciding with the Medieval Climate Anomaly. An abrupt mid-12th century decrease in agriculture is linked to socio-political change, rather than the onset of the Little Ice Age. Similarly, gradual deforestation occurring from the 16th century onwards has been linked to changes in land use during Ottoman

  17. Quantitative determinations and imaging in different structures of buried human bones from the XVIII-XIXth centuries by energy dispersive X-ray fluorescence - Postmortem evaluation.

    PubMed

    Guimarães, D; Dias, A A; Carvalho, M; Carvalho, M L; Santos, J P; Henriques, F R; Curate, F; Pessanha, S

    2016-08-01

    In this work, a non-commercial triaxial geometry energy dispersive X-ray Fluorescence (EDXRF) setup and a benchtop µ-XRF system were used to identify postmortem contamination in buried bones. For two of the individuals, unusually high concentrations of Cu and Pb, but also Zn (in one individual) were observed. The pigments of the burial shroud coverings have been identified as the source of contamination. Accurate and precise quantitative results were obtained by nondestructive process using fundamental parameters method taking into account the matrix absorption effects. A total of 30 bones from 13 individuals, buried between the mid-XVIIIth to early XIXth centuries, were analyzed to study the elemental composition and elemental distribution. The bones were collected from a church in Almada (Portugal), called Ermida do Espírito Santo, located near the Tagus River and at the sea neighbourhood. The triaxial geometry setup was used to quantify Ca, Fe, Cu, Zn, Br, Sr and Pb of powder pressed bone pellets (n=9 for each bone). Cluster analysis was performed considering the elemental concentrations for the different bones. There was a clear association between some bones regarding Fe, Cu, Zn, Br and Pb content but not a categorization between cortical and trabecular bones. The elemental distribution of Cu, Zn and Pb were assessed by the benchtop μ-analysis, the M4 Tornado, based on a polycapillary system which provides multi-elemental 2D maps. The results showed that contamination was mostly on the surface of the bone confirming that it was related to the burial shroud covering the individuals.

  18. Toward the 21st Century: Preparing Proactive Visionary Transformational Leaders for Building Learning Communities. Human Resource Development. Tampa Cluster. Winter 1994.

    ERIC Educational Resources Information Center

    Groff, Warren H.

    This document describes the Tampa Cluster human resources development (HRD) seminar that was conducted as part of Nova University's distance education program in higher education (PHE). Discussed first are HRD in the agricultural and business industrial eras and changing HRD practices/needs, Nova University's PHE and HRD program, the proceedings…

  19. The Coverage of Human Evolution in High School Biology Textbooks in the 20th Century and in Current State Science Standards

    ERIC Educational Resources Information Center

    Skoog, Gerald

    2005-01-01

    Efforts to eliminate or neutralize the coverage of evolution in high school biology textbooks in the United States have persisted with varying degrees of intensity and success since the 1920s. In particular, the coverage of human evolution has been impacted by these efforts. Evidence of the success of these efforts can be chronicled by the…

  20. The Coverage of Human Evolution in High School Biology Textbooks in the 20th Century and in Current State Science Standards

    ERIC Educational Resources Information Center

    Skoog, Gerald

    2005-01-01

    Efforts to eliminate or neutralize the coverage of evolution in high school biology textbooks in the United States have persisted with varying degrees of intensity and success since the 1920s. In particular, the coverage of human evolution has been impacted by these efforts. Evidence of the success of these efforts can be chronicled by the…

  1. The Chemical Century

    ERIC Educational Resources Information Center

    Lapp, Ralph E.

    1973-01-01

    Discusses present and future problems of producing clean energy. Graphically presents the changing patterns of fuel use in the United States over the past century, and predicts population growth and energy sources and consumption up to the year 2100 for the United States and the world. (JR)

  2. The Chemical Century

    ERIC Educational Resources Information Center

    Lapp, Ralph E.

    1973-01-01

    Discusses present and future problems of producing clean energy. Graphically presents the changing patterns of fuel use in the United States over the past century, and predicts population growth and energy sources and consumption up to the year 2100 for the United States and the world. (JR)

  3. [Cardiopulmonary resuscitation through centuries].

    PubMed

    Gajić, Vladimir

    2011-01-01

    THE ANCIENT TIMES: Many early civilisations left testimonies about ancient times and resuscitation, as well. Some of them did it successfully and some of them did it less successfully; however, all of them wished to help a dying person and to bring him back to life. The first trustworthy note can be found in the Bible--Old Testament as a very realistic description of resuscitation of a child. THE MIDDLE AGES: The medieval scientists, Paracelsus and Vesalius, described first successful resuscitation attempts in the 15th and 16th century. These two men successfully applied ventilation methods by air inflation with blacksmith bellows. THE MODERN ERA: The first defibrillation was recorded in the 18th century in England, which was conducted by one of the volunteer society members. With the development of mechanics and techniques, the first precursors of modern respirators were introduced in the 19th century. The age of modern cardiopulmonary resuscitation began in the middle of 20th century, when Dr Peter Safar brought in the combination of artificial ventilation and chest compressions as the standard for implementing resuscitation. Adrenalin and defibrillation were introduced into the resuscitation techniques by Dr Redding and Dr Kouwenhaven, respectively; thus beginning the advance life support administration, which has been applied, with minor changes, until today.

  4. Suidas (tenth century)

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    Greek encyclopedist. In the course of reading Suidas's Lexicon, EDMOND HALLEY mistakenly connected the naming of the Saros cycle of 223 synodic months by the tenth century Greek lexicographer Suidas with the eclipse cycle of the same period. The solar eclipse cycle is thus now known by the name that Suidas used for another phenomenon. Halley's mistake accounts for the historical confusion that th...

  5. Singing and science. Invited lecture at the 7th Pan-European voice conference (PEVOC7), Groningen, August 28 to September 1, 2007.

    PubMed

    Wendler, Juergen

    2008-01-01

    Starting out from Manuel Garcia, attention is paid to the work of outstanding personalities having excelled both in performing arts as singers as well as in scientific elaborations. The main focus will be on two aspects: the controversies about the principles of voice production as provoked by Raoul Husson and his revolutionary ideas, and the influence of the vocal tract on the formation of the sound of the voice. Both of these topics offer the opportunity of referring to the basic contributions of the Groningen voice research pioneers Janwillem van den Berg and his scholar Harm Schutte. For the online edition, supplementary material in the form of video and audio clips contributes to a kaleidoscopic compilation of a series of selected fragments representing the fascinating field of the human voice.

  6. Richard Bradley: a unified, living agent theory of the cause of infectious diseases of plants, animals, and humans in the first decades of the 18th century.

    PubMed

    Santer, Melvin

    2009-01-01

    During the years 1714 to 1721, Richard Bradley, who was later to become the first Professor of Botany at Cambridge University, proposed a unified, unique, living agent theory of the cause of infectious diseases of plants and animals and the plague of humans. Bradley's agents included microscopic organisms, revealed by the studies of Robert Hooke and Antony van Leeuwenhoek. His theory derived from his experimental studies of plants and their diseases and from microscopic observation of animalcules in different naturally occurring and artificial environments. He concluded that there was a microscopic world of "insects" that lived and reproduced under the appropriate conditions, and that infectious diseases of plants were caused by such "insects." Since there are structural and functional similarities between plants and animals, Bradley concluded that microscopic organisms caused human and animal infectious diseases as well. However, his living agent cause of infectious diseases was not accepted by the contemporary scientific society.

  7. "The Purple Island" of Phineas Fletcher: allusions to the anatomy of the human body in English poetry up to the end of the seventeenth century.

    PubMed

    Young, John Riddington

    2005-06-01

    The Bible declared that God created man in His own image. The concept that this divine pattern occurred not only in Man (the Microcosm), but was eternally repeated throughout Creation in the Macrocosm (Universe) and the Geocosm (Earth), was the basis of the important Doctrine of Correspondences, in which similarities were sought between man and nature, (e.g. the comparable morphology of a human brain and a walnut). This article outlines the relevance of this concept in early herbal medicine. Contemporary poems describing correspondences to the anatomy of the human body are the examined, in particular The Purple Island, by Phineas Fletcher. The Reverend Phineas Fletcher (1582 - 1650) was an English metaphysical poet and The Purple Island (1633), his most famous work, was an epic poem describing the anatomy of the human body in allegorical terms. It is compared to an island, with veins and arteries as purple rivers flowing through the chief cities of Liver, Heart and Braine. This has been acknowledged as one of the best and also one of the last great examples of the tradition of poetic correspondence in English literature.

  8. Sedimentary lipid biomarker record of human-induced environmental change during the past century in Lake Changdang, Lake Taihu basin, Eastern China.

    PubMed

    Zhang, Yongdong; Su, Yaling; Liu, Zhengwen; Sun, Kaihong; Kong, Lingyang; Yu, Jinlei; Jin, Miao

    2017-09-21

    During the past hundred years, the Lake Taihu basin has been greatly impacted by human interventions. The undesirable changes in water quality of lakes, presumably caused by the human activities, remain relatively undescribed in this area. In order to investigate these anthropogenic effects, a (210)Pb dated sediment core from a relatively small lake in the upper reaches of Lake Taihu known as Lake Changdang was subject to a detailed lipid biomarker study and other geochemical analyses including quantification of biogenic silica (BSi), nutrients and heavy metals. Based on the results, the recent environmental history of Lake Changdang can be divided into three periods. The first period from approximately 1906 to 1950, represents a natural state, with minimal anthropogenic impact on the lake. Human induced environmental change is recorded in the following stage, ca. 1950-1982, during which the trophic status of the lake increased slightly in response to inputs of agricultural waste and nitrogen (N) and phosphorus (P) based fertilizers. In particular, the signs of eutrophication during this phase accelerated from ca. 1973, perhaps owing to large-scale using phosphate based chemical fertilizer around the lake at the time. A second phase of nutrient input in the most recent stage, ca. from 1982 to 2016, initiated by wastewater discharge from rapid urbanization and industrialization of the catchment, greatly enhanced the nutrient level in the lake. However, the central zone of the lake has yet to reach a phytoplankton-dominated stable state, with both algae and aquatic macrophytes tracking an increased trend in productivity driven by intermediate nutrient levels in the water of this zone. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. The Effects of Improved Photoelectric Properties of PEDOT:PSS by Two-Step Treatments on the Performance of Polymer Solar Cells Based on PTB7-Th:PC(71)BM.

    PubMed

    Zhao, Ling; Zhao, Suling; Xu, Zheng; Huang, Di; Zhao, Jiao; Li, Yang; Xu, Xurong

    2016-01-13

    In this paper, we present a smart two-step treated method to simultaneously improve the work function, conductivity, and transmittance of poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) ( PSS). With the two-step treated PSS, the short-circuit current density of polymer solar cells (PSCs) based on PTB7-Th:PC71BM increases from 13.41 to 22.10 mA/cm(2), and the power conversion efficiency increases from 7.35% to 9.82% with 33% improvement. The underlying mechanisms on performance improvement of PSCs can be summarized as follows: (1) two-step treated PSS with the improved work function and the conductivity, which contributes significantly to the charge collection of PSCs; and (2) two-step treated PSS with higher transmittance, which is of benefit to the light absorption of the active layer in PSCs.

  10. Identifying 21st Century Capabilities

    ERIC Educational Resources Information Center

    Stevens, Robert

    2012-01-01

    What are the capabilities necessary to meet 21st century challenges? Much of the literature on 21st century skills focuses on skills necessary to meet those challenges associated with future work in a globalised world. The result is a limited characterisation of those capabilities necessary to address 21st century social, health and particularly…

  11. The Future of Infant and Young Children's Food: Food Supply/Manufacturing and Human Health Challenges in the 21st Century.

    PubMed

    Venter, Carina; Maslin, Kate

    2016-01-01

    Infant food and weaning practices are highly debated with lots of unanswered questions. It is becoming more apparent that early-life feeding may have an effect on the long-term health of humans, particularly for noncommunicable diseases such as obesity and allergic diseases. It is important to understand how environmental influences in early life can affect the development of the immune system and metabolic profiling. In terms of nutrition and diet, one should consider the role of the total/whole diet, as well as particular nutrients in the development of noncommunicable diseases. Providing the appropriate nutrition for infants during the weaning age needs to address factors such as the microbial load of the food, nutrient composition, presence/absence of allergens and appropriate textures. These factors are of importance irrespective of whether the food is homemade or produced commercially, and need to take environmental factors and food resources into account.

  12. [Jews in European pharmacy from the seventh to the early twentieth centuries].

    PubMed

    Arndt, Tomáš; Dohnal, František

    This article deals with less familiar theme - the status of Jewish doctors and pharmacists in the history of pharmacy from the 7th century AD to the early 20th century. They played an important role in the history of the Iberian Peninsula - initially under Muslim and after the Reconquista in 1492 under Christian rule. Most of them chose assimilation into the surrounding milieu, some of them escaped before the Christian Inquisition. Despite persecution, it was the golden age of Jewish medicine and pharmacy. During the existence of the Frankish empire we find only rare mentions of them - Jews isolated in the area of urban Jewish ghettos. Jewish doctors and pharmacists found better employment first in some Protestant countries (England, Holland). In Germany and Central Europe they gained ground at the end of the 19th century. A number of prominent scientists, especially from Eastern Europe, at the turn of the 19th and 20th centuries found a solution in immigration to the US to escape were anti-Semitism.Key words: Jews pharmacy Arab empire pharmacology.

  13. [The Dynamics of the Composition of mtDNA Haplotypes of the Ancient Population of the Altai Mountains from the Early Bronze Age (3rd Millennium BC) to the Iron Age (2nd-1st Centuries BC)].

    PubMed

    Gubina, M A; Kulikov, I V; Babenko, V N; Chikisheva, T A; Romaschenko, A G; Voevoda, M I; Molodin, V I

    2016-01-01

    The mtDNA polymorphism in representatives of various archaeological cultures of the Developed Bronze Age, Early Scythian, and Hunnish-Sarmatian periods was analyzed (N = 34). It detected the dominance of Western-Eurasian haplotypes (70.6%) in mtDNA samples from the representatives of the ancient population of the Early Bronze Age--Iron Age on the territory of Altai Mountains. Since the 8th to the 7th centuries BC, a sharp increase was revealed in the Eastern-Eurasian haplogroups A, D, C, andZ (43.75%) as compared to previous cultures (16.7%). The presence of haplotype 223-242-290-319 of haplogroup A8 in Dolgans, Itelmens, Evens, Koryaks, and Yakuts indicates the possible long-term presence of its carriers in areas inhabited by these populations. The prevalence of Western-Eurasian haplotypes is observed not only in the Altai Mountains but also in Central Asia (Kazakhstan) and the South of the Krasnoyarsk Krai. All of the three studied samples from the Western-Eurasian haplogroups were revealed to contain U, H, T, and HV. The ubiquitous presence of haplotypes of haplogroup H and some haplogroups of cluster U (U5al, U4, U2e, and K) in the vast territory from the Yenisei River basin to the Atlantic Ocean may indicate the direction of human settlement, which most likely occurred in the Paleolithic Period from Central Asia.

  14. Increased winds in California's Channel Islands; Evaluation of trends in reanalysis model back-casts over the last half century with implications for human impacts

    NASA Astrophysics Data System (ADS)

    Katz, S. L.

    2011-12-01

    As elsewhere, in the Southern California Bight (SCB) the role of coastal winds in driving local ocean circulation has lead to extensive research on the character of the atmospheric boundary layer, and the recognition that wind stress and curl have increased in the recent past. However, around Northern Channel Islands in the SCB, local mariners have claimed that recently conditions have gotten perceptibly windier. The general pattern of winds in this area include strong equartorward flow along the central California coast outside the SCB and discretely weaker flow in the inner SCB with a pronounced transition south and east of Point Conception. Increased surface winds have numerous implications for local commerce and maritime safety, including limitations on days at sea by fishermen, tourists and commercial traffic. However, human perception of environmental conditions are often biased by perceptions of extreme events as representative of larger scale or longer term conditions. To evaluate if recent perceptions are accurate, we evaluated trends in surface winds generated by NCAR/NCEP and European Center for Medium Range Weather Forecasts (ECMWF) reanalysis models. Reanalysis back-casts revealed that indeed surface winds in the areas of the outer Southern California Bight are increasingly windy on average, and that averages are increasing due to increasing frequency of wind events, rather than the entire distribution of winds shifting to higher speeds. In some localized areas the number of days within a year that exceed 20knots (10.31 m/s) on average are increasing at a rate of one additional day per year in the NCAR/NCEP data. The utility of 20knots is this is wind speed that can trigger a small craft warning from the US Coast Guard, and which will in turn affect human activity on the sea. The spatial distribution of the increasing trends indicates that there is a focus of increasing winds to the South of Point Conception and North West of San Nicolas Island within

  15. The exodus of health professionals from sub-Saharan Africa: balancing human rights and societal needs in the twenty-first century.

    PubMed

    Ogilvie, Linda; Mill, Judy E; Astle, Barbara; Fanning, Anne; Opare, Mary

    2007-06-01

    Increased international migration of health professionals is weakening healthcare systems in low-income countries, particularly those in sub-Saharan Africa. The migration of nurses, physicians and other health professionals from countries in sub-Saharan Africa poses a major threat to the achievement of health equity in this region. As nurses form the backbone of healthcare systems in many of the affected countries, it is the accelerating migration of nurses that will be most critical over the next few years. In this paper we present a comprehensive analysis of the literature and argue that, from a human rights perspective, there are competing rights in the international migration of health professionals: the right to leave one's country to seek a better life; the right to health of populations in the source and destination countries; labour rights; the right to education; and the right to non-discrimination and equality. Creative policy approaches are required to balance these rights and to ensure that the individual rights of health professionals do not compromise the societal right to health.

  16. A half-century ago physicists missed a major public service opportunity, costing the human race widespread chronic illness and many deaths!

    NASA Astrophysics Data System (ADS)

    Lundquist, Marjorie

    2005-03-01

    Radar-pulsed microwave (MW) radiation-helped the Allies win World War II but health concerns soon arose. Alerted to a syndrome resembling mild radiation poisoning,^1 a worried M.D. surveyed radar-exposed workers, finding a high incidence of internal bleeding, 2 leukemia cases in 600 radar operators, 2 brain tumor cases in a 5-man MW research team and many complaints of headache. He sent his report^2 to the Pentagon in 1953. Alarmed Navy officers convened a meeting^3 [mostly of electrical engineers (EEs)] to identify a safe level of MW exposure for servicemen. Biophysicist Herman Schwan attended, playing a major role in establishing 10 mW/cm^2 as a thermally safe MW exposure limit. The IEEE became sole sponsor of ANSI C95 [an early health standard for radiofrequency (RF) exposure] with negative long-term consequences for human health! I review RF health standards development since 1953, comparing what physicists might have done, had they-not EEs-had this responsibility! [See also my technical abstract.] ^1 N.H. Steneck, The Microwave Debate, Cambridge, MA: MIT Press, 1984; p. 33. ^2 J.T. McLaughlin, A Study of Possible Health Hazards from Exposure to Microwave Radiation (Hughes Aircraft, Culver City CA, Feb. 9, 1953). ^3 Biological Effects of Microwaves, meeting minutes (Navy Dept. Conference, Naval Medical Research Institute, Bethesda MD, Apr. 29, 1953).

  17. Flooding in river mouths: human caused or natural events? Five centuries of flooding events in the SW Netherlands, 1500-2000

    NASA Astrophysics Data System (ADS)

    de Kraker, A. M. J.

    2015-06-01

    This paper looks into flood events of the past 500 years in the SW Netherlands, addressing the issue of what kind of flooding events have occurred and which ones have mainly natural causes and which ones are predominantly human induced. The flood events are classified into two major categories: (a) flood events that were caused during storm surges and (b) flood events which happened during warfare. From both categories a selection of flood events has been made. Each flood event is discussed in terms of time, location, extent of the flooded area and specific conditions. Among these conditions, specific weather circumstances and how long they lasted, the highest water levels reached and dike maintenance are discussed as far as flood events caused during storm surges are concerned. Flood events during warfare as both offensive and defensive strategies are relevant; the paper demonstrates that although the strategic flood events obviously were man-made, the natural feature, being the use of fresh water or sea water, of these events also played a major role. Flood events caused during storm surge may have an obvious natural cause, but the extent of the flooding and damage it caused was largely determined by man.

  18. Flooding in river mouths: human caused or natural events? Five centuries of flooding events in the SW Netherlands, 1500-2000

    NASA Astrophysics Data System (ADS)

    de Kraker, A. M. J.

    2015-01-01

    This paper looks into the flooding events of the past 500 years in the SW Netherlands addressing the issue what kind of flooding events have occurred and which ones have mainly natural causes and which ones are predominantly human induced. The flooding events are classified into two major categories: (a) flooding events that were caused during storm surges and (b) flooding events which happened during war fare. From both categories a selection of flooding events has been made. Each flooding event is discussed in terms time, location, extent of the flooded area and specific conditions. Among these conditions specific weather circumstances and how long they lasted, the highest water levels reached and dike maintenance are discussed as far as flooding events caused during storm surges are concerned. About the flooding events during war fare, offensive and defensive strategies are relevant. The paper demonstrates that although the strategic flooding events obviously were man-made, the natural feature, being the use of fresh water or sea water, of these events also played a major role. Flooding events caused during storm surge may have an obvious natural cause, but the extent of the flooding and damage it caused were largely determined by man.

  19. Biomedical education in the 21st century.

    PubMed

    Russell, John H; Stahl, Philip D; Stephenson, Jason; Whelan, Alison

    2004-01-01

    The extraordinary discoveries of 20th century medicine and technology have created a scientific renaissance. This explosion of new knowledge and the tantalizing potential it holds for altering the course of human health and disease will change the practice of medicine and require the education of a new generation of translational/clinical scientists and physician-scientists as well as an accelerated evolution of the teaching paradigms for the training of physicians.

  20. European Immunology Congress (7th), Jerusalem, Israel.

    DTIC Science & Technology

    1985-11-22

    patients with cirrhosis , AIDS, or can- - regulatory defect more fundamental than cer. It is well established that the * the mere lack of IgA . In IgC2...Department of Pathology, Free Univers- ported on a study of patients with de- ity Hospital, Amsterdam, The Nether- ficiencies in immunoglobulin A ( IgA ...and (4-!!DOY) which, unlike CY, does not with selective IgA deficiency. All pa- . need liver conversion for its action-- tients had undetectable IgA

  1. 7th International Immunoglobulin Conference: Poster presentations.

    PubMed

    Warnatz, K; Ballow, M; Stangel, M; Bril, V

    2014-12-01

    The pan-European survey provides useful information on the accessibility and trends of intravenous and subcutaneous immunoglobulin (IVIg/SCIg) therapy, which is used to treat primary immunodeficiency disorders (PIDs). Although immunoglobulin (Ig) therapy is the first-line treatment for PIDs, the mechanisms of action of Ig therapy may differ according to the condition it is used to treat. Moreover, intriguing presentations suggest that further investigation is required to understand more clearly both the haematological and immunoregulatory effects of therapeutic immunoglobulin. This can ultimately provide more information on optimizing Ig therapy efficacy, and establish whether individualized dosing regimens for patients will be conducive to better clinical outcomes. In addition to treating autoimmune and inflammatory conditions, there is evidence to suggest that immunoglobulins can potentially play a role in transplantation, which warrants further investigation for future use.

  2. Mathematics 7th Year, Part 1.

    ERIC Educational Resources Information Center

    New York City Board of Education, Brooklyn, NY. Bureau of Curriculum Development.

    This curriculum bulletin is one of a planned series of bulletins designed to meet the needs of teachers and supervisors. The materials in this bulletin consist of a series of daily lesson plans for use by teachers in presenting a modern program of seventh year mathematics. In these lesson plans are developed the concepts, skills, and applications…

  3. Mathematics, 7th year, Part 2.

    ERIC Educational Resources Information Center

    New York City Board of Education, Brooklyn, NY.

    The materials in this bulletin consist of a series of daily lesson plans for use by teachers in presenting a modern program of seventh year mathematics. In these lesson plans are developed concepts, skills , and applications. There is an emphasis on (1) an understanding of mathematical structure, (2) growth of a number system, (3) relations and…

  4. 7th International Immunoglobulin Conference: Immunodeficiencies

    PubMed Central

    Schmidt, R E; Ochs, H D

    2014-01-01

    Most primary immunodeficiency disorders (PID) are the result of single gene defects. Based on this fact, more than 240 different entities have been identified. Those PIDs with predominant antibody deficiency are treated with immunoglobulin (Ig) replacement therapy. This review focuses on the diagnosis, clinical characteristics and treatment of patients suffering from PID, or secondary immunodeficiency disorders (SID) caused, for instance, by irradiation, immunosuppressive drugs or thymectomy. Common variable immunodeficiency (CVID) is the most commonly diagnosed and least understood form of PID, with a heterogeneous range of symptoms and genotypes, requiring individualized treatment plans. This includes adjusting the dose and treatment interval, administrating Ig by intravenous or subcutaneous injection by either pump or push, and finally deciding which treatment options are best for a given patient. Ig therapy can also be used to treat immunodeficiencies resulting from lymphoproliferative and autoimmune diseases or immunosuppression following organ transplantation; however, there is an urgent need for research in this field. Accurate and early diagnosis of PID is important to ensure that optimal treatment is started early to maintain the patient's health. Detailed patient registries have been established to increase awareness of PID, as well as provide a valuable resource for further research. PMID:25546741

  5. 7th International Immunoglobulin Conference: Immunodeficiencies

    PubMed Central

    Schmidt, R E; Ochs, H D

    2014-01-01

    Awareness of the challenges involved in diagnosing and treating a heterogeneous group of immunodeficiency disorders is growing. The improvements in neonatal screening offer new methods to ensure that primary immunodeficiencies (PIDs) are diagnosed as early as possible, enabling accurate treatment and the prevention of life-threatening infections and other complications. Additionally, the need to individualize patient therapy in order to optimize both clinical outcomes and quality-of-life is obvious and is exemplified by the ability to switch between intravenous and subcutaneous immunoglobulin administration offering flexible treatment regimens. However, further research is crucial in order to determine the optimal treatment for secondary immunodeficiencies, and to gain greater understanding of the underlying causes of PIDs, including common variable immunodeficiency. The information relating to the growth of patient registries is encouraging, with approximately 25 000 patients with PIDs included in the two registries discussed. Registries such as this are vital for future research, as well as providing an educational resource. PMID:25546748

  6. 7th International Immunoglobulin Conference: Immunomodulation

    PubMed Central

    Danieli, M G; Shoenfeld, Y

    2014-01-01

    Immunomodulation uses synthetic, natural and recombinant preparations to modify the immune response to a desired level, typically to treat specific autoimmune diseases, as will be discussed in this section. Rheumatoid arthritis (RA) is a common systemic autoimmune disease, affecting 1% of the population worldwide. Currently, a first-line disease-modifying therapy for RA is methotrexate; however, more than 40 monoclonal antibodies are in use or under investigation for the treatment of RA. This panoply of biological disease-modifying agents means that clinicians can make use of drugs with different mechanisms of action should one type become ineffective. In autoimmune pemphigus conditions, identification of pathogenic autoantibodies against intercellular cadherin desmoglein 1 and/or 3 antigens is one of the criteria for appropriate diagnosis. In pemphigoid conditions, autoantibodies are directed against bullous pemphigoid antigens BP230 and BP180, and in both types of immunobullous disease intravenous immunoglobulin (IVIg), as adjuvant therapy in combination with a cytotoxic drug, is effective in reducing autoantibody levels, disease severity and background steroid use. Further studies are required to establish the role of monoclonal antibodies in the treatment of autoimmune bullous disease. IVIg may also be effective in another at-risk population with autoimmune disease, namely secondary recurrent miscarriage (RM). However, the mechanism of action of IVIg in secondary RM is largely unknown, although levels of natural killer cell biomarkers, particularly CD56+, have been shown to decline after IVIg treatment [1-6]. Data from meta-analyses of heterogeneous placebo-controlled trials indicate that IVIg may be effective in secondary RM, but most trials to date have used immunomodulatory doses lower than those considered to be efficient in autoimmune disease. The results of a recently completed study may help to address this question. PMID:25546784

  7. NRP 7th Edition: Are You Prepared?

    PubMed

    Zaichkin, Jeanette; Mccarney, Linda; Weiner, Gary

    2016-01-01

    The seventh edition of the American Academy of Pediatrics/American Heart Association Neonatal Resuscitation Program (NRP) materials must be in use by January 1, 2017. As in previous editions, changes in resuscitation science are based on an international review and consensus of current resuscitation science. The seventh edition NRP materials also include enhancements to training materials aimed at improving the quality of NRP instruction and providing the opportunity for ongoing education. A standardized approach to instructor training, an online Instructor Toolkit, eSim cases, and a new learning management system are among the new resources.

  8. 7(th) International Immunoglobulin Conference: Poster presentations.

    PubMed

    Warnatz, K; Ballow, M; Stangel, M; Bril, V

    2014-12-01

    Immunoglobulin (Ig) therapy is the mainstay of treatment for primary antibody deficiency disorders and has proved to be efficacious in specific autoimmune and inflammatory diseases. Additionally, due to the role of Ig in complement activation, it is being used increasingly in solid organ transplantation. Furthermore, Ig is the primary or secondary treatment in some immune-mediated neuropathies such as chronic inflammatory demyelinating polyneuropathy (CIDP) or multifocal motor neuropathy (MMN). This session discusses trends of Ig use in Europe, proposed mechanisms of action, adverse effects and the potential role of Ig therapy in transplantation. Dr Šedivá reported that Ig therapy is available in all European countries, although dosing is not always optimal, due partly to reimbursement plans. Subcutaneous immunoglobulin (SCIg) has become increasingly accessible in recent years; however, the chosen route of administration still varies widely between countries. Dr Berger's presentation on optimization of Ig therapy in neuropathies, and Dr Rojavin's report on a pharmacometric model to determine the serum IgG levels achieved by different dosing regimens in primary antibody deficiency (PAD) patients, led to the challenging concept of using individualized dosing strategies. Dr Klehmet reported on the potential benefit of using antigen-specific T cell responses as a biomarker of IVIg responsiveness in CIDP patients, while Dr von Gunten provided an insight into the mechanisms of action of Ig preparations, suggesting that the immunoregulatory effects of IgG may be mediated by IgG antibodies against glycans. Dr Basta reported on the potential thrombogenic adverse effects associated with Ig therapy. Although these adverse events are rare, further studies are needed to clarify the relationship between Ig replacement and immunomodulatory therapy and these adverse reactions. In transplantation, Dr Carbone described that prophylactic IVIg treatment was found to decrease the incidence of severe infection in IgG hypogammaglobulinaemia patients undergoing heart transplantations. Furthermore, Dr Clatworthy reported that inactivating polymorphisms in the inhibitory receptor FcγRIIB do not impact upon kidney allograft survival.

  9. 7th International Immunoglobulin Conference: Poster Presentations

    PubMed Central

    Warnatz, K; Ballow, M; Stangel, M; Bril, V

    2014-01-01

    Immunoglobulin (Ig) therapy is the mainstay of treatment for primary antibody deficiency disorders and has proved to be efficacious in specific autoimmune and inflammatory diseases. Additionally, due to the role of Ig in complement activation, it is being used increasingly in solid organ transplantation. Furthermore, Ig is the primary or secondary treatment in some immune-mediated neuropathies such as chronic inflammatory demyelinating polyneuropathy (CIDP) or multifocal motor neuropathy (MMN). This session discusses trends of Ig use in Europe, proposed mechanisms of action, adverse effects and the potential role of Ig therapy in transplantation. Dr Šedivá reported that Ig therapy is available in all European countries, although dosing is not always optimal, due partly to reimbursement plans. Subcutaneous immunoglobulin (SCIg) has become increasingly accessible in recent years; however, the chosen route of administration still varies widely between countries. Dr Berger's presentation on optimization of Ig therapy in neuropathies, and Dr Rojavin's report on a pharmacometric model to determine the serum IgG levels achieved by different dosing regimens in primary antibody deficiency (PAD) patients, led to the challenging concept of using individualized dosing strategies. Dr Klehmet reported on the potential benefit of using antigen-specific T cell responses as a biomarker of IVIg responsiveness in CIDP patients, while Dr von Gunten provided an insight into the mechanisms of action of Ig preparations, suggesting that the immunoregulatory effects of IgG may be mediated by IgG antibodies against glycans. Dr Basta reported on the potential thrombogenic adverse effects associated with Ig therapy. Although these adverse events are rare, further studies are needed to clarify the relationship between Ig replacement and immunomodulatory therapy and these adverse reactions. In transplantation, Dr Carbone described that prophylactic IVIg treatment was found to decrease the incidence of severe infection in IgG hypogammaglobulinaemia patients undergoing heart transplantations. Furthermore, Dr Clatworthy reported that inactivating polymorphisms in the inhibitory receptor FcγRIIB do not impact upon kidney allograft survival. PMID:25546796

  10. The 7th International Cryocooler Conference

    NASA Astrophysics Data System (ADS)

    1993-04-01

    The partial contents of this document include the following: SDIO and Air Force Cryocooler Technology Developments at USAF Phillips Laboratory; JPL Cryocooler Development and Test Program Overview; Development and Demonstration of a Diaphragm Stirling 65 K Standard Spacecraft Cryocooler; Stirling Space Cooler; Thermal, Vibration, and Reliability Test Results for a Balanced 80 K Cryocooler; Spacecraft Cooler Characterization; Performance of a Long Life Reverse Brayton Cryocooler; SDI Cryocooler Producibility Program; Miniature Pulse Tube Cooler; Flow Patterns Intrinsic to the Pulse Tube Refrigerator; Experimental Investigation of the Regenerative Magnetic Refrigerator Operating Between 4.2 K and 1.8 K; A 4 K Gifford-McMahon Refrigerator for Radio Astronomy; A Stirling Cycle Cryocooler for 4 K Applications; Regenerator Performance and Refrigeration Mechanism for 4 K GM Refrigerator Using Rare Earth Compound Regenerator Materials; Superfluid Stirling Refrigerator with a Counterflow Regenerator; Graded and Nongraded Regenerator Performance; Evolution of the 10 K Periodic Sorption Refrigerator Concept; Development of a Periodic 10 K Sorption Cryocooler; Assessment of a Hydrogen Joule-Thomson Expander and Vanadium Hydride Sorption Beds for 20 K Cryocoolers; Design of a Metal Hydride Sorption Cryocooler System; Linear Compressor for JT Cryocooler; JT Cryostat with Liquid-Solid Cryogen Reservoir; Design of A Metal Hydride Sorption Cryocooler System; Linear Compressor for JT Cooler; and Phase Equilibria in Cryogenic Mixtures.

  11. Fundamentals of Physics, 7th Edition

    NASA Astrophysics Data System (ADS)

    Halliday, David; Resnick, Robert; Walker, Jearl

    2004-05-01

    No other book on the market today can match the 30-year success of Halliday, Resnick and Walker's Fundamentals of Physics! In a breezy, easy-to-understand style the book offers a solid understanding of fundamental physics concepts, and helps readers apply this conceptual understanding to quantitative problem solving. This book offers a unique combination of authoritative content and stimulating applications.

  12. Can extracapsular lymph node involvement be a tool to fine-tune pN1 for adenocarcinoma of the oesophagus and gastro-oesophageal junction in the Union Internationale contre le Cancer (UICC) TNM 7th edition?†.

    PubMed

    Nafteux, Philippe; Lerut, Toni; De Hertogh, Gert; Moons, Johnny; Coosemans, Willy; Decker, Georges; Van Veer, Hans; De Leyn, Paul

    2014-06-01

    The current (7th) International Union Against Cancer (UICC) pN staging system is based on the number of positive lymph nodes but does not take into consideration the characteristics of the metastatic lymph nodes itself. In particular, it has been suggested that tumour penetration beyond the lymph node capsule in metastatic lymph nodes, which is also called extracapsular lymph node involvement, has a prognostic impact. The aim of the current study was to assess the prognostic value of extracapsular (EC) and intracapsular (IC) lymph node involvement (LNI) in adenocarcinoma of the oesophagus and gastro-oesophageal junction (GOJ) and to assess its potential impact on the 7th edition of the UICC TNM manual. From 2000 to 2010, all consecutive adenocarcinoma patients with primary R0-resection (n = 499) were prospectively included for analysis. The number of resected lymph nodes, number of positive lymph nodes and number of EC-LNI/IC-LNI were determined. Extracapsular spread was defined as infiltration of cancer cells beyond the capsule of the positive lymph node. Two hundred and eighteen (43%) patients had positive lymph nodes. Cancer-specific 5-year survival in lymph node-positive patients was significantly (P < 0.0001) worse compared with lymph node-negative patients, being 88.3 vs 28.7%, respectively. In 128 (58.7%) cases EC-LNI was detected. EC-LNI showed significantly worse cancer-specific 5-year survival compared with IC-LNI, 19.6 vs 44.0% (P < 0.0001). In the pN1 category (1 or 2 positive LN's-UICC stages IIB and IIIA), this was 30.4% vs 58%; (P = 0.029). In higher pN categories, this effect was no longer noticed. Integrating these findings into an adapted TNM classification resulted in improved homogeneity, monotonicity of gradients and discriminatory ability indicating an improved performance of the staging system. EC-LNI is associated with worse survival compared with IC-LNI. EC-LNI patients show survival rates that are more closely associated with the current

  13. A century of editors.

    PubMed

    Riley, R W

    1983-07-08

    They are unalike and far apart, these 13 past editors of The Journal. Between Nathan S. Davis's first issue and William R. Barclay's retirement, there was almost a century of change in medicine, society, the American Medical Association, prose style, and editorial needs. During these years, the editors ranged from the brilliant organizers John B. Hamilton and George H. Simmons to the diligent John H. Hollister and the devoted Johnson F. Hammond. There were editors with the hot determination of James C. Culbertson, John H. Talbott, and Robert H. Moser, and there were those with the cool precision of Austin Smith and Hugh H. Hussey. They varied from Morris Fishbein, who wrote and spoke "with the grade of an eagle in its unhindered soar," to Truman W. Miller, who wrote scarcely a word. Here, briefly, they are together.

  14. A century of silence.

    PubMed

    Danielian, Jack

    2010-09-01

    This paper addresses how crimes of genocide go beyond a need for naked power, economic aggrandizement, or territorial conquest. Such crimes involve psychogenic and psychodynamic underpinnings that can be terrifying to contemplate. Yet their psychological study is essential. The Armenian genocide has been taken as a point of reference. Because the Armenian genocide has resulted in nearly a century-long effort of perpetrator denial, it can provide an important case study of how long-standing trauma and denial reinforce each other and illuminate each other. As a result, this genocide has aptly been called the "secret genocide," the "unremembered genocide," and a "crime without a name." The author holds that genocidal trauma (and trauma in general) is contagious and the contagion is likely to be insidious. All who come in contact with it can come away marked, including victim, victim families and progeny, observers, advocates, researchers, and yes, perpetrators.

  15. [Working on the ward as part of the medical school curriculum: the influence of final year students on learning outcomes of medical students in their 7th semester and their feeling integrated].

    PubMed

    Nikendei, Christoph; Schrauth, Markus; Kraus, Bernd; Herzog, Wolfgang; Jünger, Jana

    2007-01-01

    Integrating medical students into their future working environment is of utmost importance in order to ensure a smooth transition from university life to clinical practice. In the German-speaking area, there has so far been no quantitative analysis of the extent or the quality of supervision received by medical students during their ward clerkship during their clinical studies in the specialist field of internal medicine. In the summer of 2005, 161 medical students in their 6th and 7th semester undertook ward clerkships on internal wards at the University Clinic of Heidelberg and its academic hospitals. Using a questionnaire, a survey was conducted among these students about the intensity and quality of supervision received during their work on ward. Medical students working on the wards of academic hospitals were significantly more frequently co-supervised by senior physicians (p < 0.001), while a higher level of co-supervision by final year students was reported for the University Clinic (p < 0.001). Students supervised by final year students reported greater subjective learning outcomes (p < 0.001). However, this had no effect on the extent to which students felt integrated on the ward. Final year students play a central role in incorporating medical students into the ward routines of teaching hospitals. While they cannot replace instruction or supervision by a qualified physician, the promising potential of "peer-teaching" programmes should be utilized and junior physicians should be systematically prepared for and supervised in this important function.

  16. 21st century art of human anatomy.

    PubMed

    Crook, Eleanor; Allen, Rachael; Cooper, Margot; Sulzmann, Catherine; Temple-Cox, Lisa; Hines, Tonya; Lyons, Lucy

    2014-01-01

    The Session looks at the contemporary role of the medical artist with strategies for the education of medical artists and medical students. The wider topic of medical art in forensics, research and literature is explored as a close look taken at European art and science courses and collaborations.

  17. Preparing for the 21st Century: The EFG Experiment.

    ERIC Educational Resources Information Center

    Barker, Joel A.

    1994-01-01

    An EFG school seeks to prepare students for the 21st century by assuming that education is a pathway to be climbed and that curriculum must be connected to the real world. It develops competencies in three domains: (1) ecological, the relationship between humans and the planet; (2) futures, humans' relationship with time; and (3) global,…

  18. America's future: Transition to the 21st Century

    SciTech Connect

    Boyer, W.H.

    1984-01-01

    The last several centuries have led humanity to believe that each succeeding generation can expect to live better than did the previous generation. But this is no longer true, and, to survive, the human species must successfully face four impending crises: overpopulation, the destruction of the biosphere, the end of cheap and available energy, and the threat of thermonuclear holocaust.

  19. Maternal Genetic Ancestry and Legacy of 10th Century AD Hungarians

    NASA Astrophysics Data System (ADS)

    Csősz, Aranka; Szécsényi-Nagy, Anna; Csákyová, Veronika; Langó, Péter; Bódis, Viktória; Köhler, Kitti; Tömöry, Gyöngyvér; Nagy, Melinda; Mende, Balázs Gusztáv

    2016-09-01

    The ancient Hungarians originated from the Ural region in today’s central Russia and migrated across the Eastern European steppe, according to historical sources. The Hungarians conquered the Carpathian Basin 895-907 AD, and admixed with the indigenous communities. Here we present mitochondrial DNA results from three datasets: one from the Avar period (7th-9th centuries) of the Carpathian Basin (n = 31) one from the Hungarian conquest-period (n = 76) and a completion of the published 10th-12th century Hungarian-Slavic contact zone dataset by four samples. We compare these mitochondrial DNA hypervariable segment sequences and haplogroup results with published ancient and modern Eurasian data. Whereas the analyzed Avars represents a certain group of the Avar society that shows East and South European genetic characteristics, the Hungarian conquerors’ maternal gene pool is a mixture of West Eurasian and Central and North Eurasian elements. Comprehensively analyzing the results, both the linguistically recorded Finno-Ugric roots and historically documented Turkic and Central Asian influxes had possible genetic imprints in the conquerors’ genetic composition. Our data allows a complex series of historic and population genetic events before the formation of the medieval population of the Carpathian Basin, and the maternal genetic continuity between 10th-12th century and modern Hungarians.

  20. Giambattista Vico Philosopher and Educator: Lessons for the Late Twentieth Century from an Eighteenth-Century Eccentric.

    ERIC Educational Resources Information Center

    Littleford, Michael S.

    1983-01-01

    Modern disillusionment with rationalistic and mechanistic creeds increases the relevance of the thought of Giambattista Vico, an eighteenth century thinker. Vico's "New Science" dealt with the origins of human consciousness and society, and with the development of human nature, knowledge, and institutions in ways that anticipate modern…

  1. Giambattista Vico Philosopher and Educator: Lessons for the Late Twentieth Century from an Eighteenth-Century Eccentric.

    ERIC Educational Resources Information Center

    Littleford, Michael S.

    1983-01-01

    Modern disillusionment with rationalistic and mechanistic creeds increases the relevance of the thought of Giambattista Vico, an eighteenth century thinker. Vico's "New Science" dealt with the origins of human consciousness and society, and with the development of human nature, knowledge, and institutions in ways that anticipate modern…

  2. A Century of Technology Education.

    ERIC Educational Resources Information Center

    Foster, Patrick N.

    The history of technology and industrial education in the United States provides lessons that should be heeded if current advances such as tech prep are to succeed. Practical, vocation-oriented education has been an urgent objective for U.S. education three times in the 20th century. At the turn of the century, manual training (later manual arts)…

  3. A Century of Skills Movements

    ERIC Educational Resources Information Center

    Ravitch, Diane

    2010-01-01

    The author is a historian of education and has written often about the educational enthusiasms and fads of the past century. One of her books, titled "Left Back," tells the story of the rise and fall of one fad after another across the 20th century. In brief, what she has found is that in the land of American pedagogy, innovation is frequently…

  4. 21st Century Skills Map

    ERIC Educational Resources Information Center

    Partnership for 21st Century Skills, 2011

    2011-01-01

    The Partnership for 21st Century Skills (P21) has forged alliances with key national organizations representing the core academic subjects, including Social Studies, English, Math, Science, Geography, World Languages and the Arts. These collaborations have resulted in the development of 21st Century Skills Maps that illustrate the essential…

  5. A century of smoke.

    PubMed

    Yach, D; Wipfli, H

    2006-01-01

    Tobacco kills 5 million people annually. By the mid 2020s, that figure will increase to about 10 million a year, with most of the deaths occurring in developing countries. This review explains how early technological and regulatory developments contributed to the epidemic, reveals the efforts of the tobacco industry to conceal its products' harmfulness, and stresses the role of the globalization of trade and marketing as a means of increasing consumption world-wide. The results of tens of thousands of studies published globally over the past 50 years point to an association between smoking and lung cancer and other adverse health effects, and the non-smoker's rights movement has exposed the wide-spread perils of 'secondhand' smoke. Yet, the tobacco industry continues its global expansion, and consumers in low- and middle-income countries are especially susceptible to its marketing tactics. This review ends by emphasising the need for a global public-health response, and identifies the Framework Convention on Tobacco Control as a significant effort. It stresses the need for accelerated action and innovative tobacco-control efforts, if the projected death toll is to be reduced in this century.

  6. The Cosmic Century

    NASA Astrophysics Data System (ADS)

    Longair, Malcolm S.

    2013-04-01

    Part I. Stars and Stellar Evolution up to the Second World War: 1. The legacy of the nineteenth century; 2. The classification of stellar spectra; 3. Stellar structure and evolution; 4. The end points of stellar evolution; Part II. The Large-Scale Structure of the Universe, 1900-1939: 5. The Galaxy and the nature of spiral nebulae; 6. The origins of astrophysical cosmology; Part III. The Opening up of the Electromagnetic Spectrum: 7. The opening up of the electromagnetic spectrum and the new astronomies; Part IV. The Astrophysics of Stars and Galaxies since 1945: 8. Stars and stellar evolution; 9. The physics of the interstellar medium; 10. The physics of galaxies and clusters of galaxies; 11. High-energy astrophysics; Part V. Astrophysical Cosmology since 1945: 12. Astrophysical cosmology; 13. The determination of cosmological parameters; 14. The evolution of galaxies and active galaxies with cosmic epoch; 15. The origin of galaxies and the large-scale structure of the Universe; 16. The very early Universe; References; Name index; Object index; Subject index.

  7. The Cosmic Century

    NASA Astrophysics Data System (ADS)

    Longair, Malcolm S.

    2006-06-01

    Part I. Stars and Stellar Evolution up to the Second World War: 1. The legacy of the nineteenth century; 2. The classification of stellar spectra; 3. Stellar structure and evolution; 4. The end points of stellar evolution; Part II. The Large-Scale Structure of the Universe, 1900-1939: 5. The Galaxy and the nature of spiral nebulae; 6. The origins of astrophysical cosmology; Part III. The Opening up of the Electromagnetic Spectrum: 7. The opening up of the electromagnetic spectrum and the new astronomies; Part IV. The Astrophysics of Stars and Galaxies since 1945: 8. Stars and stellar evolution; 9. The physics of the interstellar medium; 10. The physics of galaxies and clusters of galaxies; 11. High-energy astrophysics; Part V. Astrophysical Cosmology since 1945: 12. Astrophysical cosmology; 13. The determination of cosmological parameters; 14. The evolution of galaxies and active galaxies with cosmic epoch; 15. The origin of galaxies and the large-scale structure of the Universe; 16. The very early Universe; References; Name index; Object index; Subject index.

  8. The Fault Geometry and Surface Ruptures, the Damage Pattern and the Deformation Field of the 6th and 7th of April 2009, Mw=6.3 and Mw=5.6 Earthquakes in L'Aquila (Central Italy) Revealed by Ground and Space Based Observations

    NASA Astrophysics Data System (ADS)

    Papanikolaou, Ioannis; Roberts, Gerald; Foumelis, Michael; Parcharidis, Issaac; Lekkas, Efthimios; Fountoulis, Ioannis

    2010-05-01

    The 2009 Mw=6.3 L' Aquila earthquake in central Italy despite its moderate magnitude caused significant loss of life and damages, producing the highest death toll in the E.U. since the 1980 Mw=6.9 Irpinia event and the highest economic cost since the 1999 Ms=5.9 Athens earthquake. It is now recognized that such events pose a high risk in most extensional settings, such as Europe at large due both to its high rate of occurrence and proximity to human habitation, forming a typical case study scenario. The deformation pattern of the 6th and 7th of April 2009 Mw=6.3 and Mw=5.6 earthquakes in L' Aquila is revealed by DInSAR analysis and compared with earthquake environmental effects. The DInSAR predicted fault surface ruptures coincide with localities where surface ruptures have been observed in the field, confirming that the ruptures observed near Paganica village are indeed primary. These ruptures are almost one order of magnitude lower than the ruptures that have been produced by other major surrounding faults from historical earthquakes. This event ruptured a small fault segment of the fault system and not one of the major postglacial fault scarps that outcrop in the area. This explains the minor primary surface ruptures that have been reported so that the 2009 L' Aquila event can be characterized as belonging to the lower end member concerning the capacity of the existing seismic sources of the area.These faults have not been activated during the 2009 event, but have the capacity to generate significantly stronger events. DInSAR analysis shows that 66% (or 305 km2) of the area deformed has been subsided whereas the remaining 34% (or 155 km2) has been uplifted. A footwall uplift versus hangingwall subsidence ratio of about 1/3 is extracted from the mainshock. The maximum subsidence (25cm) was recorded about 4.5 km away from the primary surface ruptures and about 9km away from the epicentre. In the immediate hangingwall, subsidence did not exceeded 15cm, showing that

  9. Human Rights Attitude Scale: A Validity and Reliability Study

    ERIC Educational Resources Information Center

    Ercan, Recep; Yaman, Tugba; Demir, Selcuk Besir

    2015-01-01

    The objective of this study is to develop a valid and reliable attitude scale having quality psychometric features that can measure secondary school students' attitudes towards human rights. The study group of the research is comprised by 710 6th, 7th and 8th grade students who study at 4 secondary schools in the centre of Sivas. The study group…

  10. Revision concepts and distinctive points of the new Japanese classification for biliary tract cancers in comparison with the 7(th) edition of the Union for International Cancer Control and the American Joint Committee on Cancer staging system.

    PubMed

    Ohtsuka, Masayuki; Miyakawa, Shuichi; Nagino, Masato; Takada, Tadahiro; Miyazaki, Masaru

    2015-03-01

    The 3(rd) English edition of the Japanese classification of the biliary tract cancers (JC) is now available in this journal. The primary aim of this revision is to provide all clinicians and researchers with a common language of cancer staging at an international level. On the other hand, there are several important issues that should be solved for the optimization of the staging system. Revision concepts and major revision points of the 3(rd) English edition of the JC were reviewed. Furthermore, comparing with the 7(th) edition of staging system developed by the Union for International Cancer Control (UICC) and the American Joint Committee on Cancer (AJCC), distinctive points in the JC was discussed. In this edition of the JC, the same stage groupings as those in the UICC/AJCC staging system were basically adopted. T, N, and M categories were also identical in principle with those in the UICC/AJCC staging system, although slight modifications were proposed as the "Japanese rules". As distinctive points, perihilar cholangiocarcinomas and ampullary region carcinomas were clearly defined. Intraepithelial tumor was discriminated from invasive carcinoma at ductal resection margins. Classifications of site-specific surgical margin status remained in this edition. Histological classification was based on that in the former editions of the JC, but adopted some parts of the World Health Organization classification. The JC now share its staging system of the biliary tact carcinomas with the UICC/AJCC staging system. Future validation of the "Japanese rules" could provide important evidence to make globally standardized staging system. © 2015 Japanese Society of Hepato-Biliary-Pancreatic Surgery.

  11. The effect of the 4MAT learning model on the achievement and motivation of 7th grade students on the subject of particulate nature of matter and an examination of student opinions on the model

    NASA Astrophysics Data System (ADS)

    Aktas, İdris; Bılgın, İbrahim

    2015-01-01

    Background:Many researchers agree that students, especially primary students, have learning difficulties on the 'Particulate Nature of Matter' unit. One reason for this difficulty is not considering individual differences for teaching science. In 4MAT model learning, environment is arranged according to individual differences. Purpose:The purpose of this study is to examine (1) the effects of the 4MAT learning model on the7th grade students' academic achievement and motivation on the 'Particulate Nature of Matter' unit and (2) identify student opinions on the 4MAT model. Sample:The sample consists of 235 students (115 experimental, 120 control) in Turkey. Design and methods:Experimental groups were instructed with the 4MAT model while control groups were instructed with a traditional method. Achievement Test (AchToM) and Motivation Scale (MotScl) were administered to students as pre- and post-tests. Moreover, the opinions of students in the experimental groups on the 4MAT model were ascertained through open-ended questions after the application. Results:According to independent t-test results, statistical difference in favour of the experimental groups was detected between the post-AchToM (ES = 1.43; p < .0001) and post-MotScl (ES = 0.32; p < .05) scores. According to data obtained from the questionnaire, the application of the 4MAT model increases student motivation and participation in the lesson, lessons are more amusing and enjoyable, and the self-confidence of the students increases. Besides these positive opinions, however, a few students stated that the method took too much time, they were not motivated and it did not help them in understanding the subject. Conclusions:The 4MAT model is more effective than traditional method in terms of increasing achievement and motivation. The model takes all learners into account. Thus, the teacher or educator should use the 4MAT model to ensure all students' learning in their classroom.

  12. Prognostic and discriminative power of the 7th TNM classification for patients with surgically treated papillary renal cell carcinoma: results of a multi-institutional validation study (CORONA subtype project).

    PubMed

    May, Matthias; Surcel, Cristian; Capitanio, Umberto; Dell'Oglio, Paolo; Klatte, Tobias; Shariat, Shahrokh; Ecke, Thorsten; Wolff, Ingmar; Vergho, Daniel; Wagener, Nina; Huck, Nina; Pahernik, Sascha; Zastrow, Stefan; Wirth, Manfred; Borgmann, Hendrik; Haferkamp, Axel; Musquera, Mireia; Krabbe, Laura M; Herrmann, Edwin; Scavuzzo, Anna; Mirvald, Cristian; Hutterer, Georg; Zigeuner, Richard; Stief, Christian G; Waidelich, Raphaela; Cindolo, Luca; Kalusova, Krystina; Brookman-May, Sabine D

    2017-08-01

    Studies on the prognostic reliability of the Union for International Cancer Control tumor, node, metastasis (TNM) staging system for renal cell carcinoma (RCC) predominantly focus on clear-cell RCC. Therefore, the aim of this study was to investigate whether the oncological prognosis of surgically treated papillary RCC (papRCC) patients is reliably given by the current TNM system, by analyzing the largest database reported to date. Data on 2325 papRCC patients who underwent surgical treatment in 1984- 2015 were collated from 17 international centers (median follow-up 47 months). Tumor stage was adapted to the 7th edition of the TNM system. Multivariable, bootstrap-corrected Cox regression models were applied to assess the independent impact of the TNM system on cancer-specific mortality (CSM) and all-cause mortality (ACM). The median age at diagnosis was 63 years (interquartile range 54-70 years) and 77% of patients were male. Nephron-sparing surgery was performed in 42%, and 82% were with symptom free at diagnosis. In 6.7% (n = 156), organ metastasis (stage M1) was present at the time of surgery. On multivariable analysis, the TNM system and Fuhrman grade had an independent impact on both CSM and ACM, while patient age affected ACM only. The discriminative ability of the pT classification was significant for both endpoints: 5 year CSM rates were 5%, 17%, 36% and 56% for stages pT1, pT2, pT3 and pT4, respectively (each p < 0.001). The pT classification contributed significantly to the predictive accuracy of the CSM and ACM models by 6.3% and 2.5%, respectively (each p < 0.001). The 2010 TNM staging system can be reliably applied to papRCC patients and allows certain prognostic discrimination.

  13. Validation and Comparison of the 7th Edition of the American Joint Committee on Cancer Staging System and Other Prognostic Models to Predict Relapse-Free Survival in Asian Patients with Parotid Cancer

    PubMed Central

    Lu, Chang-Hsien; Liu, Chien-Ting; Chang, Pei-Hung; Yeh, Kun-Yun; Hung, Chia-Yen; Li, Shau-Hsuan; Lin, Yung-Chang; Yeh, Ta-Sen; Hung, Yung-Shin; Chou, Wen-Chi

    2016-01-01

    Purpose: Parotid cancer is a rare malignancy characterized by a heterogeneous histologic subtype and distinct biologic behavior. The present study aimed to externally validate and compare the performances of the American Joint Committee on Cancer (AJCC) staging system (7th Edition), Carrillo score, and Vander Poorten score in the prediction of tumor relapse probability in a large cohort of Asian parotid cancer patients. Methods: In total, 261 patients who underwent primary surgery for localized parotid cancer between 2002 and 2014 at the four affiliated hospitals of Chang Gung Memorial Hospital were identified. All patients were categorized into different prognostic groups defined by these three models for the comparison of associated relapse-free survival (RFS) rates. Results: The 5-year overall survival, cancer-specific survival, and RFS rates were 82.9%, 86.2%, and 77.5%, respectively. All three models were significantly powerful in discriminating between the tumors of patients in the lowest and highest risk groups. The c-statistic for predicting the 5-year RFS was 0.74 for the AJCC staging, 0.74 for the Vander Poorten score, and 0.62 for the Carrillo score. The AJCC staging and Vander Poorten score gave significantly high c-statistic values compared to the Carrillo score. Conclusion: Our data validated that all three models are significantly powerful in discriminating tumor relapse between patients in lowest and highest risk groups. The AJCC system and Vander Poorten score proved superior to the Carrillo score, and showed similar performances in discriminating between the 5-year RFS probabilities of low and high-risk Asian parotid cancer patients. PMID:27698923

  14. [Discovery of blood cells in the 17th century].

    PubMed

    Doubek, M

    2001-07-01

    Landmark works of the 17th century concerning observations of blood cells are quoted in the article. "Simple" and successively "compound" microscopes made their appearance in the late 16th century and early 17th century. In 1656, Frenchman Pierre Borel, physician-in-ordinary to the King Louis XIV, who first applied the microscope to medicine described a type of "worn" found in human blood. In 1657, Athanasius Kircher, a Jesuit priest and scientist from Germany, examined blood from plague victims, and described "worms" of plague. In 1661, 1664 and 1665, the blood cells were discerned by Marcello Malpighi. In 1678, the red blood corpuscles was described by Jan Swammerdam of Amsterdam, a Dutch naturalist and physician. The first complete account of the red cells was made by Anthony van Leeuwenhoek of Delft in the last quarter of the 17th century.

  15. Human-Environment Interactions during the Last 8000 Years in the Environs of the Ancient City of Ephesus, Western Turkey

    NASA Astrophysics Data System (ADS)

    Stock, F.; Knipping, M.; Pint, A.; Brückner, H.

    2014-12-01

    About 6 millennia ago the maximum Holocene transgression reached c. 20 km inland. Thereafter, the coastline has continuously shifted westwards due to the progradation of the Küçük Menderes delta and its tributaries. Consequently, settlement and harbour sites were established following the retreating coastline. Our interdisciplinary geoarchaeological research focuses on (i) the detection of spatial and temporal shifts in the coastline during the past millennia and the human response to these changes; (ii) the human impact on the landscape, especially in the environs of the Roman Harbour and the harbour canal; (iii) the reconstruction of the vegetation history of the Ephesia. More than 200 drill cores were retrieved from geo-bioarchives. For a better understanding of the depositional environments, we carried out geochemical, sedimentological, microfaunal, palynological and parasitological analyses in Ephesus' harbours and in the environs of two Neolithic settlement sites. Diagnostic ceramic finds, AMS-14C age estimates and a tephra layer were used for the chronological framework.The results reveal human impact in sediments: early agricultural use in the Neolithic period; several meters of sediment with a high concentration of fig and grape seeds in the Koressos harbour during the 6th-3rd centuries BC; an accelerated sedimentation rate up to the factor of ten in Hellenistic and Roman times. Heavy metal pollution, sugar melon and fruit tree pollen, as well as eggs of intestinal parasites occur in the Roman harbour and its canal during the prosperity period of the city. Pollen analysis revealed the dominance of deciduous oak, in a landscape with human impact, already since the 6th millennium BC. From Hellenistic times onwards, fruit trees appear next to crop and pasture farming. After the decline of the city in the 7th century AD, pine trees became dominant, presumably on abandoned land. In the Belevi swamp to the northeast of Ephesus, the ash from the Minoan

  16. Proceedings of the Symposium on the Role of Behavioral Science in Physical Security (7th Annual), The Human Element in Organizational Sensitivity, Held at White Oak, Maryland, 16-17 November 1982

    DTIC Science & Technology

    1982-11-16

    SUPPLEMENTARY NOTES This work was sponsored by the Defense Nuclear Agency under RDT& E RMSS Code B 316182466 B99QAXRFOOO61H2590D. Second Printing - March 1983...34The Man/Machine Interface as Impacted by the Ecology of the Security Person" Clifford E . Simonsen, Ph.D., and Alexander G. Schauss, American...ANOMIE--DEFINITIONAL BOUNDS AND DIAGNOSIS The term anomie first was used by Emile Durkheim in his famous study Suicide, published in 1897. He

  17. The 7th Asia Cancer Forum: from the perspective of human security, how can we collaborate as Asians in order to place cancer on the global health agenda? How can we fill in the gaps that exist among us?

    PubMed

    Kawahara, Norie; Roh, Jae Kyung; Akaza, Hideyuki; Inoue, Hajime; Shibuya, Kenji; Iwasaki, Masaru; Tsuji, Tetsuo; Nishiyama, Masanori; Nakagawara, Akira; Watanabe, Kenji; Nozaki, Shinjiro; Inoue, Manami; Sugimura, Haruhiko; Miyake, Jun; Li, Fu

    2011-06-01

    This forum has continued to discuss the inclusion of cancer on the global health agenda, and specifically the Millennium Development Goals. The seventh forum presented an overview of activities to date, supplemented by reports from Korea, local governments in Japan and representatives from the pharmaceutical industry. Discussion focused on how to engage in measures to tackle cancer prevention and achieve early detection and effective treatment, using limited resources. It was recognized that with non-communicable diseases gaining increasing attention in international dialogue, it is now of the utmost importance to share an accurate recognition of cancer research and treatment throughout Asia and the wider world. Participants concurred that cancer issues are decoupled from the development aid agenda and that cooperation should be advanced on the basis of international cooperation without recourse to governmental development aid.

  18. Sixteenth Century Astronomical Telescopy

    NASA Astrophysics Data System (ADS)

    Usher, P. D.

    2001-12-01

    Ophelia in Shakespeare's Hamlet is named for the ``moist star" which in mythology is the partner of Hamlet's royal Sun. Together the couple seem destined to rule on earth just as their celestial counterparts rule the heavens, but the tragedy is that they are afflicted, just as the Sun and Moon are blemished. In 1.3 Laertes lectures Ophelia on love and chastity, describing first Cytherean phases (crescent to gibbous) and then Lunar craters. Spots mar the Sun (1.1, 3.1). Also reported are Jupiter's Red Spot (3.4) and the resolution of the Milky Way into stars (2.2). These interpretations are well-founded and support the cosmic allegory. Observations must have been made with optical aid, probably the perspective glass of Leonard Digges, father of Thomas Digges. Notably absent from Hamlet is mention of the Galilean moons, owing perhaps to the narrow field-of-view of the telescope. That discovery is later celebrated in Cymbeline, published soon after Galileo's Siderius Nuncius in 1610. In 5.4 of Cymbeline the four ghosts dance ``in imitation of planetary motions" and at Jupiter's behest place a book on the chest of Posthumus Leonatus. His name identifies the Digges father and son as the source of data in Hamlet since Jupiter's moons were discovered after the deaths of Leonard (``leon+hart") and Thomas (the ``lion's whelp"). Lines in 5.4 urge us not to read more into the book than is contained between its covers; this is understandable because Hamlet had already reported the other data in support of heliocentricism and the cosmic model discussed and depicted by Thomas Digges in 1576. I conclude therefore that astronomical telescopy began in England before the last quarter of the sixteenth century.

  19. A Century of Galaxy Spectroscopy

    NASA Astrophysics Data System (ADS)

    Rubin, Vera C.

    1995-10-01

    The first successful spectrum of a galaxy, M31, was obtained in 1898 and published in a two-page paper in the young Astrophysical Journal (Scheiner 1899). Thus the first century of galaxy spectroscopy and the first century of the Astrophysical Journal are almost coincident; I celebrate both in this paper. I describe the very early history of the determination of internal kinematics in spiral galaxies, often by quoting the astronomers' own published words. By mid-century, observations with improved optical and radio telescopes offered evidence that much of the matter in a galaxy is dark. As the century ends, research interests have enlarged to include study of spheroidal and disk galaxies with complex nuclear (and other) kinematics. These complicated velocity patterns are understood as the result of interactions, acquisitions, and mergers, and offer clear evidence of the important role of gravitational effects in galaxy evolution.

  20. [The 20th century: 100 years of misfortune and splendor].

    PubMed

    Urdaneta-Carruyo, Eliéxer

    2005-01-01

    The 20th century has been one of the most intense and convulsive periods in the History of humanity. A century of paradoxes and contrasts, it began with optimism, it witnessed the apocalypse of two world wars, and finished with unimaginable scientific progress that gave us a new civilization that we cannot yet grasp. In this century, significant events happened that shaped our time and projected their results toward an immediate future. Some of these were providential in understanding man's life, fighting against illnesses and prolonging life, and others were of undeniable social importance for humanity. Some knowledge was based on the work of others. Philosophy was embedded in mathematics, as was science in philosophy, while politics and the economy exercised so decisive an influence in our way of feeling and living that culture and society were affected to the core. Within that century the biggest technological revolution of all the time was also created, as transcendent as it was unimaginable, which put mankind on the road to the stars with the moon landing and in the process created the information society whose signature symbol, the internet, emerged as a new demiurge. However, the 20th century, with all its misfortune and splendor, paradoxes and contrasts, creation and destruction, was the most transcendent in the whole of history and it bequeaths to the future a promising horizon in the search for a renovated meaning of life and a yearning for peaceful coexistence for the whole humanity.

  1. [The past, education and science. Félix Vicq d'Azyr and the history of medicine in the18th century].

    PubMed

    Mandressi, Rafael

    2008-01-01

    As a result of a process initiated by the end of the 1 7th century, in the second half of the 18th century the history of medicine became an autonomous branch of the medical knowledge. The uses of the past were no longer those which prevailed in the Renaissance times, and the inherited knowledge played no more a significant role in the production of active medical knowledge. The ideas of the French anatomist and doctor Félix Vicq d'Azyr (1748-1794) on the history of medicine represent an original synthesis of the new frames of historical thought, from a theoretical and methodological point of view as well as in regard with the institutional and pedagogical functions of medical history. Vicq d'Azyr was the first, in fact, to assign to what he viewed as an independent discipline a specific place as a new chair in medical education.

  2. New Archeointensity Data from Late Neolithic Yarim Tepe 1 and 2 Settlements (Northern Iraq) Dated From The Pre-Halaf and Halaf Periods (7TH-6TH Millennia BC)

    NASA Astrophysics Data System (ADS)

    Akimova, S.; Gallet, Y.; Amirov, S.; Petrova, N.

    2016-12-01

    The main objective of this study is to recover the geomagnetic field intensity variations in the Middle East during the 7th and 6th millennia BC, with a particular focus on rapid fluctuations. We will report on new archeointensity data obtained from two ancient Late Neolithic settlements called Yarim Tepe I and II, located today in Northern Iraq, which were excavated by Soviet archeologists in the seventies. Yarim Tepe II, comprising a 7-m thick sequence of cultural deposits divided into nine successive levels, is dated from the Halaf period ( 5950-5300 BC). Yarim Tepe I is dated from the Pre-Halaf period ( 6300-5950 BC), with three recognized cultural phases referred to as Hassuna I, II and III. There, the deposits form a sequence of 6.5 m, which were divided into 12 archeological levels. Most of the archeological artifacts discovered during the excavations, in particular thousands of potsherds, are stored at the repository of Archeological Institute in Moscow, where our sampling was undertaken. We collected 29 groups of potsherds from Yarim Tepe II and 22 groups from Yarim Tepe I from superimposed stratigraphic layers having on average a thickness of about 20 cm. Each group consists of at least 3 (up to 10) fragments. All analyses were carried out using the three-axis vibrating sample magnetometer Triaxe, which allows magnetization measurements of a small sample (< 1 cm3) directly at high temperatures. The experimental protocol developed for the Triaxe magnetometer takes into account both the anisotropy and cooling rate effects on thermoremanent magnetization acquisition. Together with other data previously obtained from Syria and Bulgaria, the new archeointensity results show the occurrence of rapid geomagnetic field fluctuations in the Middle East during the Late Neolithic period, in particular during the 6th millennium BC. The data from Yarim Tepe II indeed confirm the occurrence of a short-lasting intensity peak around 5500 BC, with intensity variation rates

  3. Six centuries of changing oceanic mercury

    NASA Astrophysics Data System (ADS)

    Zhang, Yanxu; Jaeglé, Lyatt; Thompson, LuAnne; Streets, David G.

    2014-11-01

    Mercury (Hg) is a global and persistent contaminant, affecting human health primarily via marine fish consumption. Large anthropogenic releases of Hg to the atmosphere by mining and coal combustion have resulted in a significant perturbation to the biogeochemical cycling of Hg. The magnitude of this perturbation and the relative roles of the ocean and land as sinks for anthropogenic Hg remain unclear. Here we use a 3-D global ocean biogeochemical model to show that surface ocean Hg concentrations have increased fourfold over the last 600 years. We find that anthropogenic Hg enters the ocean's interior predominantly by absorption onto sinking organic matter particulates, which decompose and release Hg at a depth of 500-800 m, implying that the human perturbation is largest in subsurface waters of biologically productive regions. Our model simulation predicts that over the last six centuries half of emitted anthropogenic Hg has accumulated in the oceans and marine sediments.

  4. Understanding China's Curriculum Reform for the 21st Century

    ERIC Educational Resources Information Center

    Law, Wing-Wah

    2014-01-01

    This article uses curriculum-making frameworks to analyse and reconstruct the Chinese curriculum-making model and unpack the dynamics, complexity and constraints of China's curriculum reform since the early 1990s. It argues that curriculum reform is China's main human capital development strategy for coping with the challenges of the 21st century,…

  5. Semiotic and Society in Nineteenth-Century America.

    ERIC Educational Resources Information Center

    Hoopes, James

    The intellectual changes of the 19th century were as dramatic as the economic changes of the Industrial Revolution. U.S. citizens at that time subscribed to the traditional belief that a spiritual self, grafted onto the body, was the source of life and thought. The later belief that human beings possessed complete, experiential knowledge of their…

  6. Managing Colleges into the Next Century. Coombe Lodge Report.

    ERIC Educational Resources Information Center

    Brace, Diane; And Others

    1990-01-01

    This document contains seven papers about managing Great Britain's further education colleges in the next century. The papers examine a wide range of administrative issues, including building on human resources investments through strategic planning, maintaining relationships with local education authorities, customer satisfaction as a marketing…

  7. Higher Education Staff Development: Directions for the 21st Century.

    ERIC Educational Resources Information Center

    Barnes, Jennifer; And Others

    This collection of 13 papers offers an international perspective on future directions of staff development at colleges and universities, focusing on academic staff development, higher education teaching networks, and managerial and human resource development. Papers are: (1) "Higher Education Staff Development for the 21st Century: Directions…

  8. Understanding China's Curriculum Reform for the 21st Century

    ERIC Educational Resources Information Center

    Law, Wing-Wah

    2014-01-01

    This article uses curriculum-making frameworks to analyse and reconstruct the Chinese curriculum-making model and unpack the dynamics, complexity and constraints of China's curriculum reform since the early 1990s. It argues that curriculum reform is China's main human capital development strategy for coping with the challenges of the 21st century,…

  9. Space Station in the 21st century - A social perspective

    NASA Technical Reports Server (NTRS)

    Bluth, B. J.

    1986-01-01

    A human factors and sociological consideration of Space Station crew facilities and interactions is presented which attempts to place the experiences of astronaut communities in the larger context of late 20th century industrial, economic, and cultural trends. Attention is given to the relationship of Space Station communities to 'Information Society' - related historical developments.

  10. Parenting in the 21st Century: A Return to Community

    ERIC Educational Resources Information Center

    Bogan, Yolanda K. H.

    2004-01-01

    Parents are potentially the most influential individuals in children's lives. The 21st Century parent has to compete, however, with multiple sources of information, both human and nonhuman, (e.g. children's peers, non-familial adults, TV, technology gadgets, Internet) in shaping the minds, values, and beliefs of children. In the absence of a…

  11. How much longer must medicine's science be bound by a seventeenth century world view?

    PubMed

    Engel, G L

    1992-01-01

    The exclusion of nonmaterial human phenomena mandated by medical science's continuing allegiance to a 17th century scientific world view has constituted a major obstacle to medicine's scientific maturation as a human discipline. But 20th century conceptual changes even in physics (not to mention the influence of the theory of evolution) now renders that exclusion untenable and in effect legitimizes efforts to devise scientific means appropriate for the human domain. Practical as well as theoretical issues involved in such an undertaking are discussed within the framework of a 20th century scientific world view as represented by the biopsychosocial model, a counterpart to the traditional biomedical model.

  12. Blackness and Whiteness as Historical Forces in the 20th Century United States

    ERIC Educational Resources Information Center

    Greason, Walter

    2009-01-01

    At the core of the epistemology of black identity in the 20th century United States is the assertion that freedom is a human right, not a privilege to be earned. By the late 19th century, an ideology of racial uplift had emerged that revolved around four concepts--compassion, service, education, and a commitment to social and economic justice for…

  13. Blackness and Whiteness as Historical Forces in the 20th Century United States

    ERIC Educational Resources Information Center

    Greason, Walter

    2009-01-01

    At the core of the epistemology of black identity in the 20th century United States is the assertion that freedom is a human right, not a privilege to be earned. By the late 19th century, an ideology of racial uplift had emerged that revolved around four concepts--compassion, service, education, and a commitment to social and economic justice for…

  14. Is There Any Physics After the End of the Nineteenth Century?

    ERIC Educational Resources Information Center

    Aubrecht, Gordon J., II

    The twentieth century has witnessed a burst of discovery in physics unparalleled in human history. Despite the fact that general relativity and quantum mechanics are well over half a century old, introductory physics classes in high schools, colleges, and universities essentially ignore them. These two seminal ideas, the phenomena of…

  15. Is There Any Physics After the End of the Nineteenth Century?

    ERIC Educational Resources Information Center

    Aubrecht, Gordon J., II

    The twentieth century has witnessed a burst of discovery in physics unparalleled in human history. Despite the fact that general relativity and quantum mechanics are well over half a century old, introductory physics classes in high schools, colleges, and universities essentially ignore them. These two seminal ideas, the phenomena of…

  16. Twenty-first century vaccines.

    PubMed

    Rappuoli, Rino

    2011-10-12

    In the twentieth century, vaccination has been possibly the greatest revolution in health. Together with hygiene and antibiotics, vaccination led to the elimination of many childhood infectious diseases and contributed to the increase in disability-free life expectancy that in Western societies rose from 50 to 78-85 years (Crimmins, E. M. & Finch, C. E. 2006 Proc. Natl Acad. Sci. USA 103, 498-503; Kirkwood, T. B. 2008 Nat. Med 10, 1177-1185). In the twenty-first century, vaccination will be expected to eliminate the remaining childhood infectious diseases, such as meningococcal meningitis, respiratory syncytial virus, group A streptococcus, and will address the health challenges of this century such as those associated with ageing, antibiotic resistance, emerging infectious diseases and poverty. However, for this to happen, we need to increase the public trust in vaccination so that vaccines can be perceived as the best insurance against most diseases across all ages.

  17. Twenty-first century vaccines

    PubMed Central

    Rappuoli, Rino

    2011-01-01

    In the twentieth century, vaccination has been possibly the greatest revolution in health. Together with hygiene and antibiotics, vaccination led to the elimination of many childhood infectious diseases and contributed to the increase in disability-free life expectancy that in Western societies rose from 50 to 78–85 years (Crimmins, E. M. & Finch, C. E. 2006 Proc. Natl Acad. Sci. USA 103, 498–503; Kirkwood, T. B. 2008 Nat. Med 10, 1177–1185). In the twenty-first century, vaccination will be expected to eliminate the remaining childhood infectious diseases, such as meningococcal meningitis, respiratory syncytial virus, group A streptococcus, and will address the health challenges of this century such as those associated with ageing, antibiotic resistance, emerging infectious diseases and poverty. However, for this to happen, we need to increase the public trust in vaccination so that vaccines can be perceived as the best insurance against most diseases across all ages. PMID:21893537

  18. Twenty-first-century science.

    PubMed Central

    Greenwood, M R

    1995-01-01

    Scientific life is changing in fundamental ways as the twenty-first century approaches. Advances in technology are changing methods of scientific communications and dissemination of information, while diminishing resources lead to stabilization, politicization, increased public oversight, and the potential for significant downsizing. Libraries can foster the crucial interdisciplinary connections necessary to forge a new vision of scholarship. PMID:7703945

  19. Physics in the Twentieth Century

    ERIC Educational Resources Information Center

    Weisskopf, Victor F.

    1970-01-01

    Provides a review of the great discoveries, theoretical concepts and development of physics in the 20th century. The growth and significance of diverse fields such as quantum theory, relativity theory, atomic physics, molecular physics, the physics of the solid state, nuclear physics, astrophysics, plasma physics, and particle physics are…

  20. Immigration and the American century.

    PubMed

    Hirschman, Charles

    2005-11-01

    The full impact of immigration on American society is obscured in policy and academic analyses that focus on the short-term problems of immigrant adjustment. With a longer-term perspective, which includes the socioeconomic roles of the children of immigrants, immigration appears as one of the defining characteristics of twentieth-century America. Major waves of immigration create population diversity with new languages and cultures, but over time, while immigrants and their descendants become more "American," the character of American society and culture is transformed. In the early decades of the twentieth century, immigrants and their children were the majority of the workforce in many of the largest industrial cities; in recent decades, the arrival of immigrants and their families has slowed the demographic and economic decline of some American cities. The presence of immigrants probably creates as many jobs for native-born workers as are lost through displacement. Immigrants and their children played an important role in twentieth-century American politics and were influential in the development of American popular culture during the middle decades of the twentieth century. Intermarriage between the descendants of immigrants and old-stock Americans fosters a national identity based on civic participation rather than ancestry.