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Sample records for 8 9 10

  1. 10 CFR 9.8 - Information collection requirements: OMB approval.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Information collection requirements: OMB approval. 9.8 Section 9.8 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS § 9.8 Information collection requirements: OMB approval. (a) The Nuclear Regulatory Commission has submitted the information...

  2. 10 CFR 9.8 - Information collection requirements: OMB approval.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Information collection requirements: OMB approval. 9.8 Section 9.8 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS § 9.8 Information collection requirements: OMB approval. (a) The Nuclear Regulatory Commission has submitted the information...

  3. 10 CFR 9.8 - Information collection requirements: OMB approval.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Information collection requirements: OMB approval. 9.8 Section 9.8 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS § 9.8 Information collection requirements: OMB approval. (a) The Nuclear Regulatory Commission has submitted the information...

  4. 10 CFR 9.8 - Information collection requirements: OMB approval.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Information collection requirements: OMB approval. 9.8 Section 9.8 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS § 9.8 Information collection requirements: OMB approval. (a) The Nuclear Regulatory Commission has submitted the information...

  5. 10 CFR 9.8 - Information collection requirements: OMB approval.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Information collection requirements: OMB approval. 9.8 Section 9.8 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS § 9.8 Information collection requirements: OMB approval. (a) The Nuclear Regulatory Commission has submitted the information...

  6. 9. 8' X 10' Enlargement from 4' x 5' negative ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. 8' X 10' Enlargement from 4' x 5' negative Kevin Kriesel-Coons, Photographer PUMPS AFTER REMOVAL FROM PUMPHOUSE BEFORE EXCAVATION OF POND AREA IN 1989. PHOTOGRAPHED LYING ON GROUND NEAR CROSSCUT STEAM PLANT BUILDING. - Crosscut Steam Plant, Indian Bend Pond & Pump Ditch, North side Salt River near Mill Avenue & Washington Street, Tempe, Maricopa County, AZ

  7. Fluorine-containing terpene analogs. IV. 9,9,9,10,10,10-Hexafluoro-p-menthane-1,8-diol (hexafluoroterpine)

    SciTech Connect

    Zalesskaya, I.M.; Fialkov, Yu.A.; Parakhnenko, A.I.; Yagupol'skii, I.M.

    1988-03-10

    The oxidation of trans-e,e-4-(2-hydroxyperfluoroisopropyl)cyclohexanol with pyridinium chlorochromate gave the corresponding cyclohexanone. The reaction of this product with methylmagnesium iodide gave cis- and trans-9,9,9,10,10,10-hexafluoro-p-menthane-1,8-diol, which is fluorinated analog of natural terpine.

  8. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  9. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  10. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  11. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  12. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  13. Calibration of Armed Services Vocational Aptitude Battery Forms 8, 9, and 10.

    ERIC Educational Resources Information Center

    Ree, Malcolm James; And Others

    A calibration of the Armed Forces Qualification Test (AFQT) composite of the Armed Services Vocational Aptitude Battery (ASVAB) Forms 8a, 8b, 9a, 9b, 10a, and 10b to the metric of the AFQT Form 7a (AFQT-7a) and a comparison of these outcomes to the operational calibration tables implemented 1 October 1980 are presented. A sample of applicants for…

  14. A Chemistry Course for High Ability 8th, 9th, and 10th Graders.

    ERIC Educational Resources Information Center

    Kilker, Richard, Jr.

    1985-01-01

    Describes a chemistry course designed, in cooperation with local public school districts, to intellectually challenge a group of 8th, 9th, and 10th grade students. Organic chemistry and biochemistry are integrated into the course (titled Chemistry and Everyday Life) to emphasize practical applications of chemistry. The course syllabus is included.…

  15. Antidiarrheal Thymol Derivatives from Ageratina glabrata. Structure and Absolute Configuration of 10-Benzoyloxy-8,9-epoxy-6-hydroxythymol Isobutyrate.

    PubMed

    Bustos-Brito, Celia; Vázquez-Heredia, Valeria J; Calzada, Fernando; Yépez-Mulia, Lilian; Calderón, José S; Hernández-Ortega, Simón; Esquivel, Baldomero; García-Hernández, Normand; Quijano, Leovigildo

    2016-01-01

    Chemical investigation of the leaves from Ageratina glabrata yielded four new thymol derivatives, namely: 10-benzoyloxy-8,9-dehydro-6-hydroxythymol isobutyrate (4), 10-benzoyloxy-8,9-dehydrothymol (5), 10-benzoyloxythymol (6) and 10-benzoyloxy-6,8-dihydroxy-9-isobutyryl-oxythymol (7). In addition, (8S)-10-benzoyloxy-8,9-epoxy-6-hydroxythymol isobutyrate (1), together with other two already known thymol derivatives identified as 10-benzoyloxy-8,9-epoxy-6-methoxythymol isobutyrate (2) and 10-benzoyloxy-8,9-epoxythymol isobutyrate (3) were also obtained. In this paper, we report the structures and complete assignments of the ¹H and (13)C-NMR data of compounds 1-7, and the absolute configuration for compound 1, unambiguously established by single crystal X-ray diffraction, and evaluation of the Flack parameter. The in vitro antiprotozoal assay showed that compound 1 and its derivative 1a were the most potent antiamoebic and antigiardial compounds. Both compounds showed selectivity and good antiamoebic activity comparable to emetine and metronidazole, respectively, two antiprotozoal drugs used as positive controls. In relation to anti-propulsive effect, compound 1 and 1a showed inhibitory activity, with activities comparable to quercetin and compound 9, two natural antipropulsive compounds used as positive controls. These data suggest that compound 1 may play an important role in antidiarrheal properties of Ageratina glabrata. PMID:27626392

  16. Process for manufacturing bis(2-methoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracene

    DOEpatents

    Rasmussen, Paul George; Lawton, Richard Graham

    2014-06-03

    A process to manufacture substituted tetracyano-hexaazatricyclics with the substitutions occurring at the 9 and 10 hydrogens. The process begins with 2,3-dichloro-5,6-dicyanopyrazine, which is reacted to form the desired tetracyano-hexaazatricyclic. Different process embodiments enable different reaction paths to the desired tetracyano-hexaazatricyclic. Different tetracyano-hexaazatricyclic embodiments include bis(2-methoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracene and bis(2-methoxyethoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracen- e.

  17. 40 CFR 721.10025 - 10H-Phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... C8-10-branched alkyl) derivs. 721.10025 Section 721.10025 Protection of Environment ENVIRONMENTAL...-branched alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified as 10H-phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  18. 40 CFR 721.10025 - 10H-Phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... C8-10-branched alkyl) derivs. 721.10025 Section 721.10025 Protection of Environment ENVIRONMENTAL...-branched alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified as 10H-phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  19. 40 CFR 721.10025 - 10H-Phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... C8-10-branched alkyl) derivs. 721.10025 Section 721.10025 Protection of Environment ENVIRONMENTAL...-branched alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified as 10H-phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  20. 40 CFR 721.10025 - 10H-Phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... C8-10-branched alkyl) derivs. 721.10025 Section 721.10025 Protection of Environment ENVIRONMENTAL...-branched alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified as 10H-phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  1. 40 CFR 721.10025 - 10H-Phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... C8-10-branched alkyl) derivs. 721.10025 Section 721.10025 Protection of Environment ENVIRONMENTAL...-branched alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified as 10H-phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  2. Quantitation of enantiomers of r-7,t-8,9,c-10-tetrahydroxy-7,8,9,10-tetrahydrobenzo[a]-pyrene in human urine: evidence supporting metabolic activation of benzo[a]pyrene via the bay region diol epoxide

    PubMed Central

    Hecht, Stephen S.; Hochalter, Jon Bradley

    2014-01-01

    Benzo[a]pyrene (BaP), a potent polycyclic aromatic hydrocarbon carcinogen, is widely distributed in the human environment. All humans are exposed to BaP through the diet and contact with the general environment; cigarette smokers have higher exposure. An important pathway of BaP metabolism proceeds through formation of diol epoxides including the ‘bay region diol epoxide’ 7R,8S-dihydroxy-9S,10R-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene [BaP-(7R,8S)-diol-(9S,10R)-epoxide] and the ‘reverse diol epoxide’ 9S,10R-dihydroxy-7R,8S-epoxy-7,8,9,10-tetrahydrobenzo [a]pyrene [BaP-(9S,10R)-diol-(7R,8S)-epoxide]. The bay region diol epoxide is considered a major ultimate carcinogen of BaP based on studies in cell culture and laboratory animals, but the available data in humans are less convincing. The bay region diol epoxide and the reverse diol epoxide react with H2O to produce enantiomeric BaP-tetraols that are excreted in the urine. We used chiral stationary-phase high-performance liquid chromatography and gas chromatography–negative ion chemical ionisation–tandem mass spectrometry to quantify these enantiomeric BaP-tetraols in the urine of 25 smokers and 25 non-smokers. The results demonstrated that the BaP-tetraol enantiomer representing the carcinogenic bay region diol epoxide pathway accounted for 68±6% (range 56–81%) of total BaP-tetraol in smokers and 64±6% (range 46–78%) in non-smokers. Levels of the major BaP-tetraol enantiomer decreased by 75% in smokers who quit smoking. These data provide convincing evidence in support of the bay region diol epoxide mechanism of BaP carcinogenesis in humans. PMID:25053834

  3. Vibrational and electronic spectra of 9,10-dihydrobenzo(a)pyren-7(8H)-one and 7,8,9,10-tetrahydrobenzo(a)pyrene: An experimental and computational study

    NASA Astrophysics Data System (ADS)

    Onchoke, Kefa K.; Dutta, Prabir K.; Parks, Matthew E.; Martinez, Mireya N.

    2011-10-01

    The molecular geometries, vibrational and UV-vis spectra of 9,10-dihydrobenzo(a)pyrene-7(8H)-one (9,10-H 2BaP) and 7,8,9,10-tetrahydrobenzo(a)pyrene (7,8,9,10-H 4BaP) were investigated using density functional theory (DFT-B3LYP), with the triple-ζ 6-311 + G(d,p) and Dunning's cc-pVTZ basis sets. From the comparison of infrared experimental and calculated infrared, and Raman data comprehensive assignments are made. The calculated infrared frequencies below 1800 cm -1 are in good agreement with experimental data, with an average deviation of <4 cm -1. Using the B3LYP/6-311 + G(d,p)//TD-B3LYP/6-311G(d,p) level of theory, transition energies, and oscillator strengths of the 30 lowest electronic absorption bands are assigned to π-π* transitions, with good qualitative agreement between experimental and simulated absorption data. In addition, the HOMO-LUMO gaps and their chemical hardness were analyzed.

  4. Comparative Methylation of 1,8-Dihydroxy-9,10-Anthraquinone: Chemoselectivity in the Organic Chemistry Laboratory

    ERIC Educational Resources Information Center

    Sereda, Grigori A.

    2005-01-01

    A study has shown that methylation of 1,8-dihydroxy-9,10-anthraquinone (1) with methyl tosylate is highly dependent upon reaction conditions. When the reaction is carried out by a simple heating of the reaction mixture without solvent it yields dimethyl product in a nearly quantitative yield and refluxing the same mixture of reactants in…

  5. Mucopolysaccharidosis IIIB confers enhanced neonatal intracranial transduction by AAV8 but not by 5, 9 or rh10

    PubMed Central

    Gilkes, J A; Bloom, M D; Heldermon, C D

    2016-01-01

    Sanfilippo syndrome type B (mucopolysaccharidosis IIIB, MPS IIIB) is a lysosomal storage disease resulting from deficiency of N-acetyl-glucosaminidase (NAGLU) activity. To determine the possible therapeutic utility of recombinant adeno-associated virus (rAAV) in early gene therapy-based interventions, we performed a comprehensive assessment of transduction and biodistribution profiles of four central nervous system (CNS) administered rAAV serotypes, -5, -8, -9 and -rh10. To simulate optimal earliest treatment of the disease, each rAAV serotype was injected into the CNS of neonatal MPS IIIB and control animals. We observed marked differences in biodistribution and transduction profiles between the serotypes and this differed in MPS IIIB compared with healthy control mice. Overall, in control mice, all serotypes performed comparably, although some differences were observed in certain focal areas. In MPS IIIB mice, AAV8 was more efficient than AAV5, -9 and -rh10 for gene delivery to most structures analyzed, including the cerebral cortex, hippocampus and thalamus. Noteworthy, the pattern of biodistribution within the CNS varied by serotype and genotype. Interestingly, AAV8 also produced the highest green fluorescent protein intensity levels compared with any other serotype and demonstrated improved transduction in NAGLU compared with control brains. Importantly, we also show leakage of AAV8, -9 and -rh10, but not AAV5, from CNS parenchyma to systemic organs. Overall, our data suggest that AAV8 represents the best therapeutic gene transfer vector for early intervention in MPS IIIB. PMID:26674264

  6. 40 CFR 721.10024 - 10H-Phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...-branched alkyl) derivs. 721.10024 Section 721.10024 Protection of Environment ENVIRONMENTAL PROTECTION... alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as 10H-phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs (PMN P-01-771; CAS...

  7. 40 CFR 721.10024 - 10H-Phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-branched alkyl) derivs. 721.10024 Section 721.10024 Protection of Environment ENVIRONMENTAL PROTECTION... alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as 10H-phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs (PMN P-01-771; CAS...

  8. 40 CFR 721.10024 - 10H-Phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...-branched alkyl) derivs. 721.10024 Section 721.10024 Protection of Environment ENVIRONMENTAL PROTECTION... alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as 10H-phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs (PMN P-01-771; CAS...

  9. 40 CFR 721.10024 - 10H-Phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...-branched alkyl) derivs. 721.10024 Section 721.10024 Protection of Environment ENVIRONMENTAL PROTECTION... alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as 10H-phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs (PMN P-01-771; CAS...

  10. 40 CFR 721.10024 - 10H-Phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...-branched alkyl) derivs. 721.10024 Section 721.10024 Protection of Environment ENVIRONMENTAL PROTECTION... alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as 10H-phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs (PMN P-01-771; CAS...

  11. The thermodynamic properties of 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene

    SciTech Connect

    Chirico, R.D.; Knipmeyer, S.E.; Nguyen, A.; Smith, N.K.; Steele, W.V.

    1992-12-01

    Measurements leading to the calculation of the ideal-gas thermodynamic properties are reported for 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene. Experimental methods included combustion calorimetry, adiabatic heat-capacity calorimetry, vibrating-tube densitometry, comparative ebulliometry, inclined-piston gauge manometry, and differential-scanning calorimetry (d.s.c.). Critical properties were estimated for both materials based on the measurement results. Entropies, enthalpies, and Gibbs energies of formation were derived for the ideal gases for selected temperatures between 380 K and 700 K. The property-measurement results reported here for 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene are the first for these important intermediates in the pyrene/H{sub 2} hydrogenation reaction network.

  12. PB2-588 V promotes the mammalian adaptation of H10N8, H7N9 and H9N2 avian influenza viruses.

    PubMed

    Xiao, Chencheng; Ma, Wenjun; Sun, Na; Huang, Lihong; Li, Yaling; Zeng, Zhaoyong; Wen, Yijun; Zhang, Zaoyue; Li, Huanan; Li, Qian; Yu, Yuandi; Zheng, Yi; Liu, Shukai; Hu, Pingsheng; Zhang, Xu; Ning, Zhangyong; Qi, Wenbao; Liao, Ming

    2016-01-01

    Human infections with avian influenza H7N9 or H10N8 viruses have been reported in China, raising concerns that they might cause human epidemics and pandemics. However, how these viruses adapt to mammalian hosts is unclear. Here we show that besides the commonly recognized viral polymerase subunit PB2 residue 627 K, other residues including 87E, 292 V, 340 K, 588 V, 648 V, and 676 M in PB2 also play critical roles in mammalian adaptation of the H10N8 virus. The avian-origin H10N8, H7N9, and H9N2 viruses harboring PB2-588 V exhibited higher polymerase activity, more efficient replication in mammalian and avian cells, and higher virulence in mice when compared to viruses with PB2-588 A. Analyses of available PB2 sequences showed that the proportion of avian H9N2 or human H7N9 influenza isolates bearing PB2-588 V has increased significantly since 2013. Taken together, our results suggest that the substitution PB2-A588V may be a new strategy for an avian influenza virus to adapt mammalian hosts. PMID:26782141

  13. A divergent route to 9, 10-oxygenated tetrahydroprotoberberine and 8-oxoprotoberberine alkaloids: synthesis of (±)-isocorypalmine and oxypalmatine

    PubMed Central

    Gadhiya, Satish; Ponnala, Shashikanth; Harding, Wayne W.

    2015-01-01

    A new route which is germane to the synthesis of 9,10-oxygenated tetrahydroprotoberberines and 8-oxoprotoberberines is described. The route features the use of a diester (14) generated from reaction of dimethylmalonate with an aryl halide in the presence of n-butyllithium. The amide 17 prepared in subsequent steps is a versatile precursor for the synthesis of tetrahydroprotoberberine and 8-oxoprotoberberine scaffolds using standard high-yielding reactions. In this manner, (±)-isocorypalmine and oxypalmatine have been synthesized in 23% and 22 % yields respectively. PMID:25691805

  14. Development of seal ring carbon-graphite materials (tasks 8, 9, and 10)

    NASA Technical Reports Server (NTRS)

    Fechter, N. J.; Petrunich, P. S.

    1973-01-01

    A screening study was conducted to develop improved carbon-graphite materials for use in self-acting seals at air temperatures to 1300 F (704 C). Property measurements on materials prepared during this study have shown that: (1) The mechanical properties of a carbon-graphite material were significantly improved by using a fine milled artificial graphite filler material and including intensive mixing, warm molding, and pitch impregnation in the processing; and (2) the oxidation resistance of a carbon-graphite material was improved by including fine milled boron carbide as an oxidation-inhibiting additive. These techniques were employed to develop a material that has 10 times more oxidation resistance than that of a widely used commercial grade and mechanical properties that approach those of the commercial grade.

  15. Thermoelectric Properties of Pseudogap Ti10Ru19B8 and Ti9TM2Ru18B8 (TM: Cr-Cu) Compounds

    NASA Astrophysics Data System (ADS)

    Takagiwa, Y.; Yoshida, T.; Yanagihara, D.; Kimura, K.

    2015-06-01

    The thermoelectric properties of ternary Ti10Ru19B8 and quaternary Ti9TM2Ru18B8 (TM: Cr, Mn, Fe, Co, Ni, Cu) compounds were investigated in the temperature range from 373 K to 973 K. They form pseudogaps in the electronic densities of states near the Fermi level, E F, which is suitable for thermoelectric materials. We synthesized crack-free pellet samples using arc-melting followed by spark plasma sintering. A maximum dimensionless figure of merit zT max was 0.09 at 973 K for Ti10Ru19B8 whereas a large power factor of 1.4 mW/m K2 was obtained at that temperature. The phonon thermal conductivity decreased through TM substitutions; however, the power factor also decreased due to an additional electronic density of states originated from TM d-states around E F; that is, excitations of both holes and electrons.

  16. Factors influencing the covalent binding of (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene to ribonucleic acids

    SciTech Connect

    Zytkovicz, T.H.; Liarakos, C.D.

    1984-09-01

    The covalent binding of the ultimate carcinogen (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo (alpha)pyrene (BPDE) to enriched ovalbumin messenger RNA (mRNAov) of known sequence was examined. Incubation of mRNAov with elevated concentrations of labeled BPDE in TE buffer (0.02 M Tris X HCl, 1 mM EDTA, pH 7.2) containing 0.1 M KCl and 10 mM MgCl2 resulted in approximately 30 BPDEs covalently bound per RNA molecule. Covalent binding in the absence of KCl and MgCl2 resulted in a significant increase in binding to 110 BPDEs bound per molecule or modification of 12% of the total guanosine and adenosine nucleotides present. The nucleoside adducts formed were nearly all guanosine and adenosine in a ratio of 1.6:1.0. It was also observed that digestion of mRNAov with T2 RNase prior to reaction with BPDE resulted in a 52% decrease in guanosine adduct formation and a 93% decrease in adenosine adducts compared with undigested controls. Comparison of the binding of labeled BPDE to 18 S and 28 S ribosomal RNAs and to mRNAov revealed that the guanosine adduct to adenosine adduct ratio and the number of BPDEs bound increased with increasing G-C content. The results reported here show that ionic composition of the medium, G-C content, and the presence of a polymeric state can significantly influence the quantitative and/or qualitative nucleoside BPDE adducts formed.

  17. Crystal structure of tetraaquabis(8-chloro-9,10-dioxo-9,10-dihydroanthracene-1-carboxyl-ato-κO (1))cobalt(II) dihydrate.

    PubMed

    Cai, Wen-Juan; Liu, Bo; Liu, Feng-Yi; Kou, Jun-Feng

    2014-10-01

    In the title complex, [Co(C15H6ClO4)2(H2O)4]·2H2O, the Co(II) ion is bound by two carboxylate O atoms of two 5-chloro-9,10-anthra-quinone-1-carboxyl-ate anions and four water O atoms in a trans conformation, forming an irregular octa-hedral coordination geometry. This arrangement is stabilized by intra-molecular O-H⋯O hydrogen bonds between water and carboxyl-ate. Further O-H⋯O hydrogen bonds between coordinating and non-coordinating water and carboxyl-ate produce layers of mol-ecules that extend parallel to (001). The organic ligands project above and below the plane. Those ligands of adjacent planes are inter-digitated and there are π-π inter-actions between them with centroid-centroid distances of 3.552 (2) and 3.767 (2) Å that generate a three-dimensional supra-molecular structure. PMID:25484680

  18. The anticancer activity of 3- and 10-bromofascaplysins is mediated by caspase-8, -9, -3-dependent apoptosis.

    PubMed

    Kuzmich, Alexandra S; Fedorov, Sergey N; Shastina, Valeria V; Shubina, Larisa K; Radchenko, Oleg S; Balaneva, Nadezda N; Zhidkov, Maxim E; Park, Joo-In; Kwak, Jong Y; Stonik, Valentin A

    2010-06-01

    3- and 10-Bromofascaplysins was previously found to possess cytotoxic activity. In this study, we investigated their cancer preventive and proapoptotic properties. These effects were tested on mouse skin epidermal JB6 P(+) Cl41 cell line, its stable transfectants, and human tumor HL-60, THP-1, SNU-C4, SK-MEL-28, DLD-1, MDA-MB-231, and HeLa cells using a variety of assessments, including a cell viability (MTS) assay, flow cytometry, anchorage-independent soft agar assay, luciferase assay, mitochondrial permeability assay, and Western blotting. 3- and 10-Bromofascaplysins were effective at submicromolar concentrations as the anticancer agents, which exerted their action, at least in part, through the induction of caspase-8, -9, -3-dependent apoptosis.

  19. Nevada Test Site Radionuclide Inventory and Distribution Program: Report No. 3, Areas 3, 7, 8, 9, and 10

    SciTech Connect

    McArthur, R D; Mead, S W

    1987-02-01

    As part of the Nevada Test Site Radionuclide Inventory and Distribution Program, 115 soil samples were collected and more than 1200 in situ measurements of gamma-emitting radionuclides were made in the northern and eastern parts of Yucca Flat. Analysis of the data led to estimated inventories of 215 Ci of /sup 239,240/Pu, 128 Ci of /sup 137/Cs, 92 Ci of /sup 90/Sr, 36 Ci each of /sup 241/Am and /sup 60/Co, 31 Ci of /sup 102m/Rh, 27 Ci of /sup 238/Pu, 25 Ci of /sup 174/Lu, 10 Ci of /sup 152/Eu, 8 Ci of /sup 155/Eu, 7 Ci of /sup 154/Eu, 5 Ci of /sup 125/Sb, 4 Ci of /sup 101/Rh, and 2 Ci of /sup 134/Cs in the surface soil of the accessible portion of Areas 8 and 10. Similar calculations with the data from Areas 3, 7, and 9 gave estimates of 145 Ci of /sup 239,240/Pu, 89 Ci of /sup 152/Eu, 62 Ci of /sup 90/Sr, 25 Ci of /sup 137/Cs, 14 Ci of /sup 154/Eu, 11 Ci of /sup 241/Am, 6 Ci each of /sup 60/Co and /sup 238/Pu, and 4 Ci of /sup 155/Eu. Additional in situ measurements at 30 locations in the southern part of Yucca Flat confirmed the low levels of radioactivity found there by an aerial survey. 1 ref., 57 figs., 10 tabs.

  20. Overexpression of ALDH10A8 and ALDH10A9 Genes Provides Insight into Their Role in Glycine Betaine Synthesis and Affects Primary Metabolism in Arabidopsis thaliana.

    PubMed

    Missihoun, Tagnon D; Willée, Eva; Guegan, Jean-Paul; Berardocco, Solenne; Shafiq, Muhammad R; Bouchereau, Alain; Bartels, Dorothea

    2015-09-01

    Betaine aldehyde dehydrogenases oxidize betaine aldehyde to glycine betaine in species that accumulate glycine betaine as a compatible solute under stress conditions. In contrast, the physiological function of betaine aldehyde dehydrogenase genes is at present unclear in species that do not accumulate glycine betaine, such as Arabidopsis thaliana. To address this question, we overexpressed the Arabidopsis ALDH10A8 and ALDH10A9 genes, which were identified to code for betaine aldehyde dehydrogenases, in wild-type A. thaliana. We analysed changes in metabolite contents of transgenic plants in comparison with the wild type. Using exogenous or endogenous choline, our results indicated that ALDH10A8 and ALDH10A9 are involved in the synthesis of glycine betaine in Arabidopsis. Choline availability seems to be a factor limiting glycine betaine synthesis. Moreover, the contents of diverse metabolites including sugars (glucose and fructose) and amino acids were altered in fully developed transgenic plants compared with the wild type. The plant metabolic response to salt and the salt stress tolerance were impaired only in young transgenic plants, which exhibited a delayed growth of the seedlings early after germination. Our results suggest that a balanced expression of the betaine aldehyde dehydrogenase genes is important for early growth of A. thaliana seedlings and for salt stress mitigation in young seedlings.

  1. 40 CFR 721.10023 - Benzenamine, N-phenyl-, ar ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...-rich C8-10-branched alkyl) derivs. 721.10023 Section 721.10023 Protection of Environment ENVIRONMENTAL...-10-branched alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as benzenamine, N-phenyl-, ar,ar′-(C9-rich C8-10-branched...

  2. 40 CFR 721.10023 - Benzenamine, N-phenyl-, ar ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...-rich C8-10-branched alkyl) derivs. 721.10023 Section 721.10023 Protection of Environment ENVIRONMENTAL...-10-branched alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as benzenamine, N-phenyl-, ar,ar′-(C9-rich C8-10-branched...

  3. 40 CFR 721.10023 - Benzenamine, N-phenyl-, ar ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...-rich C8-10-branched alkyl) derivs. 721.10023 Section 721.10023 Protection of Environment ENVIRONMENTAL...-10-branched alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as benzenamine, N-phenyl-, ar,ar′-(C9-rich C8-10-branched...

  4. 46 CFR 9.8 - Broken periods.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Broken periods. 9.8 Section 9.8 Shipping COAST GUARD... § 9.8 Broken periods. In computing extra compensation where the services rendered are in broken periods and less than 2 hours intervene between such broken periods the time served should be...

  5. 46 CFR 9.8 - Broken periods.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Broken periods. 9.8 Section 9.8 Shipping COAST GUARD... § 9.8 Broken periods. In computing extra compensation where the services rendered are in broken periods and less than 2 hours intervene between such broken periods the time served should be...

  6. 46 CFR 9.8 - Broken periods.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Broken periods. 9.8 Section 9.8 Shipping COAST GUARD... § 9.8 Broken periods. In computing extra compensation where the services rendered are in broken periods and less than 2 hours intervene between such broken periods the time served should be...

  7. 46 CFR 9.8 - Broken periods.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Broken periods. 9.8 Section 9.8 Shipping COAST GUARD... § 9.8 Broken periods. In computing extra compensation where the services rendered are in broken periods and less than 2 hours intervene between such broken periods the time served should be...

  8. 46 CFR 9.8 - Broken periods.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Broken periods. 9.8 Section 9.8 Shipping COAST GUARD... § 9.8 Broken periods. In computing extra compensation where the services rendered are in broken periods and less than 2 hours intervene between such broken periods the time served should be...

  9. Synthesis and antitumor evaluations of symmetrically and unsymmetrically substituted 1,4-bis[(aminoalkyl)amino]anthracene-9,10-diones and 1,4-bis[(aminoalkyl)amino]-5,8-dihydroxyanthracene-9,10-diones.

    PubMed

    Krapcho, A P; Getahun, Z; Avery, K L; Vargas, K J; Hacker, M P; Spinelli, S; Pezzoni, G; Manzotti, C

    1991-08-01

    The ipso bis displacements of fluoride from 1,4-difluoroanthracene-9,10-dione (3) and 1,4-difluoro-5,8-dihydroxyanthracene-9,10-dione (4) by excess of a diamine (or a monoamine) in pyridine at room temperature lead to the symmetrically substituted 1,4-bis-substituted analogues 5 and 6, respectively. The ipso monodisplacements of fluoride from 3 and 4 can be accomplished by treatment with less than 1 molar equiv of a diamine (or a monoamine) to yield 7 and 8, respectively. Treatment of 7 or 8 with a different diamine leads to the unsymmetrically substituted 1,4-bis[(aminoalkyl)amino]anthracene-9,10-diones 9 and 10, respectively. Many of the synthetic unsymmetrical analogues have been evaluated for their antitumor activity against L1210 in vitro and in vivo. Cross resistance of analogue 10a with mitoxantrone (2) and doxorubicin was evaluated against MDR lines in vitro against human colon carcinoma LOVO and its subline resistant to DOXO (LOVO/DOXO). Potential mechanisms for the observed cytotoxicity are presented and discussed.

  10. 40 CFR 721.10022 - Benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... C8-10-branched alkyl) derivs. 721.10022 Section 721.10022 Protection of Environment ENVIRONMENTAL...-branched alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  11. 40 CFR 721.10022 - Benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... C8-10-branched alkyl) derivs. 721.10022 Section 721.10022 Protection of Environment ENVIRONMENTAL...-branched alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  12. 40 CFR 721.10022 - Benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... C8-10-branched alkyl) derivs. 721.10022 Section 721.10022 Protection of Environment ENVIRONMENTAL...-branched alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  13. 40 CFR 721.10022 - Benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... C8-10-branched alkyl) derivs. 721.10022 Section 721.10022 Protection of Environment ENVIRONMENTAL...-branched alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  14. 40 CFR 721.10022 - Benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... C8-10-branched alkyl) derivs. 721.10022 Section 721.10022 Protection of Environment ENVIRONMENTAL...-branched alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  15. Molecular characterization of mutation and comparison of mutation profiles in the hprt gene of Chinese hamster ovary cells treated with benzo[a]pyrene trans-7,8-diol-anti-9,10-epoxide, 1-nitrobenzol[a]pyrene trans-7,8-diol-anti-9,10-epoxide, and 3-nitrobenzol[a]pyrene trans-7,8-diol-anti-9,10-epoxide

    SciTech Connect

    Zhan, D.J.; Heflich, R.H.; Fu, P.P.

    1996-12-31

    Both 1- and 3-nitrobenzol[a] pyrene (nitro-BaP) are environmental contaminants, potent mutagens in Salmonella, and moderate mutagens in Chinese hamster ovary (CHO) cells. The mutagenicity of their oxidized metabolites, trans-7,8-dihydroxy-anti-9, 10-epoxy-7,8,9,10-tetrahydro-1-nitrobenzol[a]pyrene (1-nitro-BaP-DE) and trans-7,8-dihydroxy-anti-9, 10-epoxy-7,8,9,10-tetrahydro-3-nitrobenzo[a]pyrene (3-nitro-BaP-DE), together with trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzol[a]pyren (BaP-DE), was determined in CHO-K1 cells, and the resulting mutations at the hprt locus were characterized by polymerase chain reaction (PCR) amplification of reverse-transcribed hprt mRNA, followed by DNA sequence analysis. The mutant frequencies, in mutants/10{sup 6} clonable cells, at 30 and 100 ng/ml, were BaP-DE, 248 and 456; 1-nitro-BaP-DE, 68 and 260; 3-nitro-BaP-DE, 81 and 232, respectively. In general, the three diolepoxides exhibited similar mutational spectra: (1) 64% (23/36 sequenced mutants) of BaP-DE, 53% (19/36) of 1-nitro-BaP-DE, and 64% (23/36) of 3-nitro-BaP-DE mutants resulted from simple base pair substitution, with the predominant mutation being G{r_arrow}T transversion: (2) 90%, 100%, and 100% of mutations at G:C had the mutated dG on the nontranscribed DNA strand; and (3) about one quarter of the mutants produced by each mutagen had one or more PCR products with partial or complete exon deletions. 61 refs., 1 fig., 7 tabs.

  16. 42 CFR 9.8 - Animal records.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... (9 CFR 2.35). The records may be created and retained in electronic form. (2) The animal records... Welfare Regulations section 2.35(f) (9 CFR 2.35(f)). Original records or a copy must be transferred if the... 42 Public Health 1 2014-10-01 2014-10-01 false Animal records. 9.8 Section 9.8 Public...

  17. 42 CFR 9.8 - Animal records.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... (9 CFR 2.35). The records may be created and retained in electronic form. (2) The animal records... Welfare Regulations section 2.35(f) (9 CFR 2.35(f)). Original records or a copy must be transferred if the... 42 Public Health 1 2013-10-01 2013-10-01 false Animal records. 9.8 Section 9.8 Public...

  18. 42 CFR 9.8 - Animal records.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... (9 CFR 2.35). The records may be created and retained in electronic form. (2) The animal records... Welfare Regulations section 2.35(f) (9 CFR 2.35(f)). Original records or a copy must be transferred if the... 42 Public Health 1 2011-10-01 2011-10-01 false Animal records. 9.8 Section 9.8 Public...

  19. 42 CFR 9.8 - Animal records.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... (9 CFR 2.35). The records may be created and retained in electronic form. (2) The animal records... Welfare Regulations section 2.35(f) (9 CFR 2.35(f)). Original records or a copy must be transferred if the... 42 Public Health 1 2012-10-01 2012-10-01 false Animal records. 9.8 Section 9.8 Public...

  20. 42 CFR 9.8 - Animal records.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... (9 CFR 2.35). The records may be created and retained in electronic form. (2) The animal records... Welfare Regulations section 2.35(f) (9 CFR 2.35(f)). Original records or a copy must be transferred if the... 42 Public Health 1 2010-10-01 2010-10-01 false Animal records. 9.8 Section 9.8 Public...

  1. Quantification of (7S,8R)-dihydroxy-(9R,10S)-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene adducts in human serum albumin by laser-induced fluorescence: implications for the in vivo metabolism of benzo[a]pyrene.

    PubMed

    Ozbal, C C; Skipper, P L; Yu, M C; London, S J; Dasari, R R; Tannenbaum, S R

    2000-07-01

    The ubiquitous environmental carcinogen benzo[a]pyrene (BaP) is metabolized in vivo in humans to its ultimate carcinogenic form of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE). Mouse skin tumorigenicity studies indicate that the (7R,8S,9S,10R) enantiomer of BPDE, (7R,8S)-dihydroxy-(9S,10R)-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene [(7R,8S,9S,10R)-BPDE], is a potent tumor initiator, whereas the (7S,8R,9R,10S) enantiomer of BPDE, (7S,8R)-dihydroxy-(9R,10S)-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene [(7S,8R,9R,10S)-BPDE], may act as a tumor promoter. In vitro experiments have shown that human liver microsomes are capable of metabolizing BaP to both the (7R,8S,9S,10R) and (7S,8R,9R,10S) enantiomers of BPDE. However, the metabolism of BaP to (7S,8R,9R,10S)-BPDE has not been demonstrated in humans in vivo. The adducts formed between human serum albumin (HSA) and the (7S,8R,9R,10R) and (7R,8S,9S,10R) enantiomers of BPDE have been described previously. (7S,8R,9R,10S)-BPDE forms a stable adduct at histidine146 of HSA, whereas (7R,8S,9R,10R)-BPDE forms a relatively unstable ester adduct at aspartate187 or glutamate188 of HSA. Using high-performance liquid chromatography with laser-induced fluorescence (LIF) detector, we quantified the level of (7S,8R,9R,10S)-BPDE adducts at histidine146 in HSA isolated from 63 healthy males who were population control subjects for an ongoing case-control study of bladder cancer. By design, roughly half of the participants were lifelong nonsmokers (n = 35), whereas the remaining 28 participants were current smokers of varying intensities. HP-BPDE adducts were detected in 60 of the 63 samples (95%) by HPLC-LIF. Adduct levels ranged from undetectable (<0.04 fmol/mg HSA) to 0.77 fmol/mg HSA. The samples had a mean and median (7S,8R,9R,10S)-BPDE-HSA adduct level of 0.22 and 0.16 fmol of adduct/mg albumin, respectively. Mean adduct levels did not differ between smokers and nonsmokers (P = 0.72). Occupational exposure to polycyclic

  2. High-Resolution Match Rate of 7/8 and 9/10 or Better for the Be The Match Unrelated Donor Registry.

    PubMed

    Buck, Kelly; Wadsworth, Kim; Setterholm, Michelle; Maiers, Martin; Confer, Dennis; Hartzman, Robert; Schmidt, Alexander; Yang, Soo Young; Dehn, Jason

    2016-04-01

    Estimation of the National Marrow Donor Program's Be The Match Registry 8/8 (HLA-A, -B, -C, and -DRB1) high-resolution (HR) unrelated donor (URD) match rate was determined in a prior study for each of the 4 most frequent patient race/ethnic groups in the United States: white (WH), Hispanic (HIS), Asian/Pacific Islander (API), and African American (AFA). For patients without an 8/8 HLA-matched URD, a 7/8 match, with a single allele or antigen mismatch, is often accepted by many transplant centers. A follow-up study was designed to determine the 7/8 or better match rate among the 4 major race/ethnic groups, using the same study cohort. Of previously HR tested URDs in the Be The Match Registry, 1344 were randomly selected and treated as pseudo-patients where HR testing was performed to identify a 7/8-matched URD; 98% of WH and over 80% of non-WH race/ethnic groups (HIS, API, and AFA) had at least a 7/8 match identified. In most cases after first testing to identify an 8/8-matched URD, a 7/8-matched URD was identified after typing just 1 URD. Extending criteria to identify a 9/10 match (included HLA-DQB1) showed the 9/10 absolute match rate decreased between 14% and 21% from the 7/8 match rate for the non-WH groups. This study provides a baseline 7/8 and 9/10 or better HLA match rate that can be further supplemented using the additional worldwide URD inventory. URD match rate information can equip centers in clinical planning and the education of patients seeking a life-saving therapy.

  3. Dry well conductivity monitoring report for Tanks W-8, W-9, and W-10, Oak Ridge National Laboratory, Oak Ridge, Tennessee

    SciTech Connect

    1997-10-01

    A treatability study and waste removal program are being implemented for the Gunite ad Associated Tanks Operable Unit at Oak Ridge National Laboratory, Oak Ridge, Tennessee. This report documents the instrumentation and monitoring efforts to establish baseline conductivity conditions. The simulated liquid release (SLR) testing reported here demonstrates the effectiveness of the Conductivity-monitoring method (CMM) as a liquid-release detection method for consolidation Tanks W-8 and W-9 and Tank W-10 in the South Tank Farm (STF). The results show the remarkable sensitivity of the CMM to even very small simulated releases from the tank. The SLR testing for DW-8, DW-9 and DW-10 show that the dry well conductivity monitoring will be effective in detecting potential releases from the tanks during waste removal operations. The data in this report also make clear statements about the inferred integrity of the tanks, tank pads, and drain system: (1) the data substantiate earlier work and show that Tanks W-8, W-9, and W-10 are not leaking; (2) the data show that the pads under Tanks W-8, W-9, and W-10 are integral and connected to the dry wells; (3) the STF drain system appears to be functioning properly. This report presents these results and describes the release monitoring plan for the consolidation tanks and during waste removal operations at all of the tanks in the STF.

  4. Factor Structure of the Armed Services Vocational Aptitude Battery (ASVAB), Forms 8, 9, and 10: 1981 Army Applicant Sample. Technical Report 581.

    ERIC Educational Resources Information Center

    Kass, Richard A.; And Others

    The purpose of this research is to examine the factor structure of the Armed Services Vocational Aptitude Battery (ASVAB), Forms 8, 9, and 10. The ASVAB consists of ten subtests: General Science; Arithmetic Reasoning; Word Knowledge; Paragraph Comprehension; Numerical Operations; Coding Speed; Auto Shop Information; Mathematics Knowledge;…

  5. Armed Services Vocational Aptitude Battery: Item and Factor Analyses of Forms 8, 9, and 10. Interim Report for Period October 1980 - July 1981.

    ERIC Educational Resources Information Center

    Ree, Malcolm James; And Others

    Presented is an investigation of the item and factor characteristics which make up Forms 8, 9, and 10 of the Armed Services Vocational Aptitude Battery (ASVAB). Data on the ASVAB forms were collected from mulitary enlistment applications at 20 Armed Forces Examining and Entrance Stations. Item and factor analyses were conducted on samples equated…

  6. TLR9 Ligands Induce S100A8 in Macrophages via a STAT3-Dependent Pathway which Requires IL-10 and PGE2

    PubMed Central

    Hsu, Kenneth; Chung, Yuen Ming; Endoh, Yasumi; Geczy, Carolyn L.

    2014-01-01

    S100A8 and S100A9 are highly-expressed calcium-binding proteins in neutrophils and monocytes, and in subsets of macrophages in inflammatory lesions. Unmethylated CpG motifs found in bacterial and viral DNA are potent activators of innate immunity via Toll-like receptor 9 (TLR9). S100A8, but not S100A9, mRNA and protein was directly induced by CpG-DNA in murine and human macrophages. Induction in murine macrophages peaked at 16 h. CpG-DNA-induced S100A8 required de novo protein synthesis; IL-10 and Prostaglandin E2 (PGE2) synergistically enhanced expression and promoted earlier gene induction. Inhibitors of endogenous IL-10, PGE2, and the E prostanoid (EP) 4 receptor strongly suppressed S100A8 expression, particularly when combined. Thus, S100A8 induction by E. coli DNA required both IL-10 and PGE2/EP4 signaling. The MAPKs, PI3K and JAK pathways were essential, whereas ERK1/2 appeared to play a direct role. S100A8 induction by CpG-DNA was controlled at the transcriptional level. The promoter region responsible for activation, either directly, or indirectly via IL-10 and PGE2, was located within a −178 to −34-bp region and required STAT3 binding. Because of the robust links connecting IL-10 and PGE2 with an anti-inflammatory macrophage phenotype, the induction profile of S100A8 strongly indicates a role for this protein in resolution of inflammation. PMID:25098409

  7. 40 CFR 721.9850 - 2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9- bis[2,4,6-tris(1,1-dimethylethyl)phenoxy]-.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false 2,4,8,10-Tetraoxa-3,9-diphosphaspiro undecane, 3,9- bis -. 721.9850 Section 721.9850 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances...

  8. 40 CFR 721.9850 - 2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9- bis[2,4,6-tris(1,1-dimethylethyl)phenoxy]-.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false 2,4,8,10-Tetraoxa-3,9-diphosphaspiro undecane, 3,9- bis -. 721.9850 Section 721.9850 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances...

  9. 40 CFR 721.9850 - 2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9- bis[2,4,6-tris(1,1-dimethylethyl)phenoxy]-.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false 2,4,8,10-Tetraoxa-3,9-diphosphaspiro undecane, 3,9- bis -. 721.9850 Section 721.9850 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances...

  10. 40 CFR 721.9850 - 2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9- bis[2,4,6-tris(1,1-dimethylethyl)phenoxy]-.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false 2,4,8,10-Tetraoxa-3,9-diphosphaspiro undecane, 3,9- bis -. 721.9850 Section 721.9850 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances...

  11. 40 CFR 721.9850 - 2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9-bis[2,4,6-tris(1,1-dimethylethyl)phenoxy]-.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false 2,4,8,10-Tetraoxa-3,9-diphosphaspiro undecane, 3,9-bis -. 721.9850 Section 721.9850 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances...

  12. The thermodynamic properties of 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene. [Tetrahydropyrene and hexahydropyrene

    SciTech Connect

    Chirico, R.D.; Knipmeyer, S.E.; Nguyen, A.; Smith, N.K.; Steele, W.V.

    1992-12-01

    Measurements leading to the calculation of the ideal-gas thermodynamic properties are reported for 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene. Experimental methods included combustion calorimetry, adiabatic heat-capacity calorimetry, vibrating-tube densitometry, comparative ebulliometry, inclined-piston gauge manometry, and differential-scanning calorimetry (d.s.c.). Critical properties were estimated for both materials based on the measurement results. Entropies, enthalpies, and Gibbs energies of formation were derived for the ideal gases for selected temperatures between 380 K and 700 K. The property-measurement results reported here for 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene are the first for these important intermediates in the pyrene/H[sub 2] hydrogenation reaction network.

  13. On-orbit frequency stability analysis of the GPS NAVSTAR 8 rubidium clock and NAVSTARS 9 and 10 cesium clocks. Memorandum report, January-December 1985

    SciTech Connect

    Buisson, J.A.; Largay, M.M.

    1987-09-17

    This report describes the on-orbit frequency stability performance analysis of the Global Positioning System (GPS) NAVSTAR 8 rubidium clock and the NAVSTARs 9 and 10 cesium clocks. Time-domain measurements, taken from three GPS monitor sites and from the United States Naval Observatory (USNO), were analyzed to determine the short and long-term frequency-stability performance of the NAVSTAR clocks. The data presented include measurements from 1985.

  14. Efficient Catalyst One-Pot Synthesis of 7-(Aryl)-10,10-dimethyl-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione Derivatives Complemented by Antibacterial Activity

    PubMed Central

    Al-Majedy, Yasameen K.; Kadhum, Abdul Amir H.; Mohamad, Abu Bakar

    2016-01-01

    The problem of bacteria resistance to many known agents has inspired scientists and researchers to discover novel efficient antibacterial drugs. Three rapid, clean, and highly efficient methods were developed for one-pot synthesis of 7-(aryl)-10,10-dimethyl-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione derivatives. Three components are condensed in the synthesis, 4-hydroxycoumarin, 5,5-dimethyl-1,3-cyclohexanedione, and aromatic aldehydes, using tetrabutylammonium bromide (TBAB), diammonium hydrogen phosphate (DAHP), or ferric chloride (FeCl3), respectively. Each method has different reaction mechanisms according to the catalyst. The present methods have advantages, including one-pot synthesis, excellent yields, short reaction times, and easy isolation of product. All catalysts utilized in our study could be reused several times without losing their catalytic efficiency. All synthesized compounds were fully characterized and evaluated for their antibacterial activity. PMID:27563671

  15. Efficient Catalyst One-Pot Synthesis of 7-(Aryl)-10,10-dimethyl-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione Derivatives Complemented by Antibacterial Activity.

    PubMed

    Al-Majedy, Yasameen K; Al-Amiery, Ahmed A; Kadhum, Abdul Amir H; Mohamad, Abu Bakar

    2016-01-01

    The problem of bacteria resistance to many known agents has inspired scientists and researchers to discover novel efficient antibacterial drugs. Three rapid, clean, and highly efficient methods were developed for one-pot synthesis of 7-(aryl)-10,10-dimethyl-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione derivatives. Three components are condensed in the synthesis, 4-hydroxycoumarin, 5,5-dimethyl-1,3-cyclohexanedione, and aromatic aldehydes, using tetrabutylammonium bromide (TBAB), diammonium hydrogen phosphate (DAHP), or ferric chloride (FeCl3), respectively. Each method has different reaction mechanisms according to the catalyst. The present methods have advantages, including one-pot synthesis, excellent yields, short reaction times, and easy isolation of product. All catalysts utilized in our study could be reused several times without losing their catalytic efficiency. All synthesized compounds were fully characterized and evaluated for their antibacterial activity. PMID:27563671

  16. IL-12p40/IL-10 Producing preCD8α/Clec9A+ Dendritic Cells Are Induced in Neonates upon Listeria monocytogenes Infection

    PubMed Central

    Delbauve, Sandrine; Caminschi, Irina; Lahoud, Mireille H.; Shortman, Ken; Flamand, Véronique

    2016-01-01

    Infection by Listeria monocytogenes (Lm) causes serious sepsis and meningitis leading to mortality in neonates. This work explored the ability of CD11chigh lineage DCs to induce CD8+ T-cell immune protection against Lm in mice before 7 days of life, a period symbolized by the absence of murine IL-12p70-producing CD11chighCD8α+ dendritic cells (DCs). We characterized a dominant functional Batf3-dependent precursor of CD11chigh DCs that is Clec9A+CD205+CD24+ but CD8α- at 3 days of life. After Lm-OVA infection, these pre-DCs that cross-present Ag display the unique ability to produce high levels of IL-12p40 (not IL-12p70 nor IL-23), which enhances OVA-specific CD8+ T cell response, and regulatory IL-10 that limits OVA-specific CD8+ T cell response. Targeting these neonatal pre-DCs for the first time with a single treatment of anti-Clec9A-OVA antibody in combination with a DC activating agent such as poly(I:C) increased the protection against later exposure to the Lm-OVA strain. Poly(I:C) was shown to induce IL-12p40 production, but not IL-10 by neonatal pre-DCs. In conclusion, we identified a new biologically active precursor of Clec9A+ CD8α- DCs, endowed with regulatory properties in early life that represents a valuable target to augment memory responses to vaccines. PMID:27074026

  17. IL-12p40/IL-10 Producing preCD8α/Clec9A+ Dendritic Cells Are Induced in Neonates upon Listeria monocytogenes Infection.

    PubMed

    Torres, David; Köhler, Arnaud; Delbauve, Sandrine; Caminschi, Irina; Lahoud, Mireille H; Shortman, Ken; Flamand, Véronique

    2016-04-01

    Infection by Listeria monocytogenes (Lm) causes serious sepsis and meningitis leading to mortality in neonates. This work explored the ability of CD11c(high) lineage DCs to induce CD8+ T-cell immune protection against Lm in mice before 7 days of life, a period symbolized by the absence of murine IL-12p70-producing CD11c(high)CD8α+ dendritic cells (DCs). We characterized a dominant functional Batf3-dependent precursor of CD11c(high) DCs that is Clec9A+CD205+CD24+ but CD8α- at 3 days of life. After Lm-OVA infection, these pre-DCs that cross-present Ag display the unique ability to produce high levels of IL-12p40 (not IL-12p70 nor IL-23), which enhances OVA-specific CD8+ T cell response, and regulatory IL-10 that limits OVA-specific CD8+ T cell response. Targeting these neonatal pre-DCs for the first time with a single treatment of anti-Clec9A-OVA antibody in combination with a DC activating agent such as poly(I:C) increased the protection against later exposure to the Lm-OVA strain. Poly(I:C) was shown to induce IL-12p40 production, but not IL-10 by neonatal pre-DCs. In conclusion, we identified a new biologically active precursor of Clec9A+ CD8α- DCs, endowed with regulatory properties in early life that represents a valuable target to augment memory responses to vaccines. PMID:27074026

  18. Improved efficiency in organic light-emitting devices with tris-(8-hydroxyquinoline) aluminium doped 9,10-di(2-naphthyl) anthracene emission layer

    NASA Astrophysics Data System (ADS)

    Yuan, Yongbo; Lian, Jiarong; Li, Shuang; Zhou, Xiang

    2008-11-01

    Organic light-emitting devices with tris-(8-hydroxyquinoline) aluminium (Alq3) doped 9,10-di(2-naphthyl) anthracene (ADN) as the emission layer (EML) have been fabricated. These devices exhibit efficient electroluminescence (EL) originated from the Alq3 as the mass ratio of Alq3 to ADN was varied from 1 to 50%. The devices with an optimal Alq3 mass ratio of 10 wt% showed a peak EL efficiency and an external quantum efficiency of 9.1 cd A-1 and 2.7% at a luminance of 1371 cd m-2, which is improved by a factor of 2.2 compared with 4.1 cd A-1 and 1.2% at a luminance of 3267 cd m-2 for conventional devices with the neat Alq3 as the EML.

  19. Detection and assignment of proteins encoded by rice black streaked dwarf fijivirus S7, S8, S9 and S10.

    PubMed

    Isogai, M; Uyeda, I; Lee, B C

    1998-06-01

    The proteins encoded by rice black streaked dwarf fijivirus (RBSDV) genomic segments 7-10 (S7-S10) were characterized. Open reading frames (ORFs) from these segments were expressed as fusion proteins in Escherichia coli. Antibodies raised against the expressed products were used as probes to determine whether the viral ORFs encode structural proteins. In Western blots, antibodies to the expressed S8 and S10 products reacted with a core capsid (65 kDa) and a major outer capsid (56 kDa) protein, respectively, while none of the antibodies to S7 and S9 products reacted with structural proteins. Antisera to RBSDV S7 ORF1 and S9 ORF1 each detected a single protein of the predicted size in total protein extracts from infected rice plants and viruliferous Laodelphax striatellus. Immunoelectron microscopy revealed that antibodies to RBSDV S7 ORF1 and RBSDV S9 ORF1 reacted with tubular structures and viroplasm, respectively, in sections of both infected maize plants and viruliferous L. striatellus. Antisera to ORF2 of S7 and S9 failed to detect any proteins in the infected tissue using either Western blotting or immuno-electron microscopic techniques.

  20. The haloarchaeal MCM proteins: bioinformatic analysis and targeted mutagenesis of the β7-β8 and β910 hairpin loops and conserved zinc binding domain cysteines

    PubMed Central

    Kristensen, Tatjana P.; Maria Cherian, Reeja; Gray, Fiona C.; MacNeill, Stuart A.

    2014-01-01

    The hexameric MCM complex is the catalytic core of the replicative helicase in eukaryotic and archaeal cells. Here we describe the first in vivo analysis of archaeal MCM protein structure and function relationships using the genetically tractable haloarchaeon Haloferax volcanii as a model system. Hfx. volcanii encodes a single MCM protein that is part of the previously identified core group of haloarchaeal MCM proteins. Three structural features of the N-terminal domain of the Hfx. volcanii MCM protein were targeted for mutagenesis: the β7-β8 and β910 β-hairpin loops and putative zinc binding domain. Five strains carrying single point mutations in the β7-β8 β-hairpin loop were constructed, none of which displayed impaired cell growth under normal conditions or when treated with the DNA damaging agent mitomycin C. However, short sequence deletions within the β7-β8 β-hairpin were not tolerated and neither was replacement of the highly conserved residue glutamate 187 with alanine. Six strains carrying paired alanine substitutions within the β910 β-hairpin loop were constructed, leading to the conclusion that no individual amino acid within that hairpin loop is absolutely required for MCM function, although one of the mutant strains displays greatly enhanced sensitivity to mitomycin C. Deletions of two or four amino acids from the β910 β-hairpin were tolerated but mutants carrying larger deletions were inviable. Similarly, it was not possible to construct mutants in which any of the conserved zinc binding cysteines was replaced with alanine, underlining the likely importance of zinc binding for MCM function. The results of these studies demonstrate the feasibility of using Hfx. volcanii as a model system for reverse genetic analysis of archaeal MCM protein function and provide important confirmation of the in vivo importance of conserved structural features identified by previous bioinformatic, biochemical and structural studies. PMID:24723920

  1. Coexistence of Avian Influenza Virus H10 and H9 Subtypes among Chickens in Live Poultry Markets during an Outbreak of Infection with a Novel H10N8 Virus in Humans in Nanchang, China.

    PubMed

    Hu, Maohong; Li, Xiaodan; Ni, Xiansheng; Wu, Jingwen; Gao, Rongbao; Xia, Wen; Wang, Dayan; He, Fenglan; Chen, Shengen; Liu, Yangqing; Guo, Shuangli; Li, Hui; Shu, Yuelong; Bethel, Jeffrey W; Liu, Mingbin; Moore, Justin B; Chen, Haiying

    2015-01-01

    Infection with the novel H10N8 virus in humans has raised concerns about its pandemic potential worldwide. We report the results of a cross-sectional study of avian influenza viruses (AIVs) in live poultry markets (LPMs) in Nanchang, China, after the first human case of H10N8 virus infection was reported in the city. A total of 201 specimens tested positive for AIVs among 618 samples collected from 24 LPMs in Nanchang from December 2013 to January 2014. We found that the LPMs were heavily contaminated by AIVs, with H9, H10, and H5 being the predominant subtypes and more than half of the LPMs providing samples that were positive for the H10 subtype. Moreover, the coexistence of different subtypes was common in LPMs. Of the 201 positive samples, 20.9% (42/201) had mixed infections with AIVs of different HA subtypes. Of the 42 mixed infections, 50% (21/42) showed the coexistence of the H9 and H10 subtypes, with or without H5, and were from chicken samples. This indicated that the H10N8 virus probably originated from segment reassortment of the H9 and H10 subtypes. PMID:25766608

  2. Improved efficiency for green and red emitting electroluminescent devices using the same cohost composed of 9,10-di(2-naphthyl) anthracene and tris-(8-hydroxyquinolinato) aluminum

    NASA Astrophysics Data System (ADS)

    Zhu, Jianzhuo; Li, Wenlian; Chu, Bei; Yang, Dongfang; Zhang, Guang; Liu, Huihui; Chen, Yiren; Su, Zisheng; Wang, Junbo; Wu, Shuanghong

    2009-12-01

    We demonstrate highly efficient green and red fluorescence dyes-doped electroluminescent devices using cohost strategy. The cohost system is composed of tris-(8-hydroxyquinolinato) aluminum (Alq) and 9,10-di(2-naphthyl) anthracene (ADN). The maximum current efficiencies are increased by 54% and 104% for green and red devices by optimizing the ratio between ADN and Alq in the cohost compared to the conventional Alq single-host devices, respectively. We attribute the improvement of efficiencies to balanced hole and electron injection into the emitting layer, the enlarged width of recombination region and the multiple emission processes.

  3. Synthesis of novel 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthene-11-thiones and evaluation of their biocidal effects.

    PubMed

    Khurana, Jitender M; Magoo, Devanshi; Aggarwal, Komal; Aggarwal, Nisha; Kumar, Rajesh; Srivastava, Chitra

    2012-12-01

    Novel 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthene-11-thiones have been synthesized in high yields by treatment of the corresponding oxo analogs with Lawesson's reagent. The structure has been confirmed by X-ray analysis. The compounds were tested for in vitro antifungal activity against Rhizoctonia bataticola, Sclerotium rolfsii, Fusarium oxysporum and Alternaria porii. The compounds exhibited moderate to good activity against all pathogens. Insecticidal activity of these compounds against Spodoptera litura was observed to be comparable to commercial pyrethroid insecticide, cypermethrin. The urease inhibitory activity has also been studied. PMID:23153816

  4. 8,9-dihydroxy-8,9-dihydrodibenzo[a,l]pyrene is a potent morphological cell-transforming agent in C3H10T(1)/(2)Cl8 mouse embryo fibroblasts in the absence of detectable stable covalent DNA adducts.

    PubMed

    Nesnow, S; Davis, C; Padgett, W T; Adams, L; Yacopucci, M; King, L C

    2000-06-01

    The comparative genotoxic effects of racemic trans-8,9-dihydroxy-8, 9-dihydrodibenzo[a,l]pyrene (trans-DB[a,l]P-8,9-diol), the metabolic K-region dihydrodiol of dibenzo[a,l] pyrene (DB[a,l]P) (dibenzo[def, p]chrysene) and DB[a,l]P in transformable mouse embryo C3H10T(1)/(2)Cl8 (C3H10T(1)/(2)) fibroblasts was investigated. The C3H10T(1)/(2) mouse embryo morphological cell-transforming activities of these polycyclic aromatic hydrocarbons (PAHs) were assayed using concentration-response studies. At concentrations of 33 nM and above both trans-DB[a,l]P-8,9-diol and DB[a,l]P produced significant (and similar) numbers of type II and III foci per dish and numbers of dishes with type II and II foci. Concomitant cytotoxicity studies revealed a reduction in colony survival of approximately 25% up to 198 nM for both PAHs. DNA adducts of trans-DB[a,l]P-8,9-diol and DB[a,l]P in C3H10T(1)/(2) cells were analyzed by a (32)P-post-labeling TLC/HPLC method. No adducts were observed in the DNA of C3H10T(1)/(2) cells treated with trans-DB[a, l]P-8,9-diol at concentrations that induced morphological cell transformation. Under the same exposure and chromatographic conditions, DNA adducts of deoxyadenosine and deoxyguanosine derived from the fjord region anti-DB[a,l]P-11,12-diol-13,14-epoxide and syn-DB[a,l]P-11,12-diol-13,14-epoxide were observed in the DNA of DB[a,l]P-treated cells. These results indicate that trans-DB[a,l]P-8, 9-diol has intrinsic genotoxic activity equal to that of DB[a,l]P, based on morphological cell transformation of mouse embryo fibroblasts. The activity of trans-DB[a,l]P-8,9-diol is apparently not associated with the formation of observable stable covalent DNA adducts. These results suggest that under appropriate conditions, trans-DB[a,l]P-8,9-diol may serve as an intermediate in the genotoxicity of DB[a,l]P.

  5. CO2 laser photoacoustic measurements of ethanol absorption coefficients within infrared region of 9.2-10.8 μm

    NASA Astrophysics Data System (ADS)

    Ivascu, I. R.; Matei, C. E.; Patachia, M.; Bratu, A. M.; Dumitras, D. C.

    2016-06-01

    Absorption coefficients of the ethanol vapors at atmospheric pressure and room temperature were measured by photoacoustic technique using a cw, line-tunable, frequency-stabilized CO2 laser as radiation source. The spectrum of the employed CO2 laser includes 54 lines with wavelengths in the infrared region of 9.2-10.8 μm and power levels up to 4.7 W. Measurements revealed a predominant absorption for ethanol within 9.4 μm band of the CO2 laser spectrum, where the highest values of the absorption coefficients were recorded: 3.68 cm- 1 atm- 1 at 9R(20) line and 3.65 cm- 1 atm- 1 at 9R(22) line. The estimated detection range covers six orders of magnitude, from a minimum of 30 ppbV to a maximum of 4% concentration of ethanol in nitrogen, which proves the suitability of the photoacoustic technique for accurate measurements of the ethanol concentration in various applications.

  6. CO2 laser photoacoustic measurements of ethanol absorption coefficients within infrared region of 9.2-10.8 μm.

    PubMed

    Ivascu, I R; Matei, C E; Patachia, M; Bratu, A M; Dumitras, D C

    2016-06-15

    Absorption coefficients of the ethanol vapors at atmospheric pressure and room temperature were measured by photoacoustic technique using a cw, line-tunable, frequency-stabilized CO2 laser as radiation source. The spectrum of the employed CO2 laser includes 54 lines with wavelengths in the infrared region of 9.2-10.8μm and power levels up to 4.7W. Measurements revealed a predominant absorption for ethanol within 9.4μm band of the CO2 laser spectrum, where the highest values of the absorption coefficients were recorded: 3.68cm(-1)atm(-1) at 9R(20) line and 3.65cm(-1)atm(-1) at 9R(22) line. The estimated detection range covers six orders of magnitude, from a minimum of 30ppbV to a maximum of 4% concentration of ethanol in nitrogen, which proves the suitability of the photoacoustic technique for accurate measurements of the ethanol concentration in various applications.

  7. CO2 laser photoacoustic measurements of ethanol absorption coefficients within infrared region of 9.2-10.8 μm.

    PubMed

    Ivascu, I R; Matei, C E; Patachia, M; Bratu, A M; Dumitras, D C

    2016-06-15

    Absorption coefficients of the ethanol vapors at atmospheric pressure and room temperature were measured by photoacoustic technique using a cw, line-tunable, frequency-stabilized CO2 laser as radiation source. The spectrum of the employed CO2 laser includes 54 lines with wavelengths in the infrared region of 9.2-10.8μm and power levels up to 4.7W. Measurements revealed a predominant absorption for ethanol within 9.4μm band of the CO2 laser spectrum, where the highest values of the absorption coefficients were recorded: 3.68cm(-1)atm(-1) at 9R(20) line and 3.65cm(-1)atm(-1) at 9R(22) line. The estimated detection range covers six orders of magnitude, from a minimum of 30ppbV to a maximum of 4% concentration of ethanol in nitrogen, which proves the suitability of the photoacoustic technique for accurate measurements of the ethanol concentration in various applications. PMID:27045783

  8. 22 CFR 9a.8 - Physical protection.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... provisions of 22 CFR 9.45 through 9.49. ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Physical protection. 9a.8 Section 9a.8 Foreign... ENERGY PROGRAMS; RELATED MATERIAL § 9a.8 Physical protection. Except as provided in § 9a.7, the...

  9. 22 CFR 9a.8 - Physical protection.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... provisions of 22 CFR 9.45 through 9.49. ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Physical protection. 9a.8 Section 9a.8 Foreign... ENERGY PROGRAMS; RELATED MATERIAL § 9a.8 Physical protection. Except as provided in § 9a.7, the...

  10. 22 CFR 9a.8 - Physical protection.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... provisions of 22 CFR 9.45 through 9.49. ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Physical protection. 9a.8 Section 9a.8 Foreign... ENERGY PROGRAMS; RELATED MATERIAL § 9a.8 Physical protection. Except as provided in § 9a.7, the...

  11. PCSK9 polymorphism in a Tunisian cohort: identification of a new allele, L8, and association of allele L10 with reduced coronary heart disease risk.

    PubMed

    Slimani, Afef; Hrira, Mohamed Yahia; Najah, Mohamed; Jomaa, Walid; Maatouk, Faouzi; Hamda, Khaldoun Ben; Abifadel, Marianne; Rabès, Jean-Pierre; Boileau, Catherine; Rouis, Mustapha; Slimane, Mohamed Naceur; Varret, Mathilde

    2015-02-01

    The c.61_63dupCTG (L10) allele of rs72555377 polymorphism in PCSK9 has been reported to be associated with low-density lipoprotein-cholesterol (LDL-C) levels and with a decreased risk of coronary artery disease (CAD). We investigated the effect of two known alleles for rs72555377, L10 and L11, on the risk of CAD in a Tunisian cohort (218 patients diagnosed by angiography and 125 control subjects). Two subgroups of patients were defined by their level of stenosis: ≥50% for CAD and <50% for no-CAD. The genotypes were obtained by the size measurement of fluorescent-labeled PCR products. We identified a novel allele for the rs72555377 polymorphism: an in-frame deletion, c.61_63delCTG (L8). The frequency of the L10 allele was significantly higher in the no-CAD subgroup than in the CAD subgroup (0.210 vs 0.114, p = 0.045), and than in the subgroup of CAD patients presenting a stenosis ≥50% in two or three major coronary arteries (0.210 vs 0.125, p = 0.028). Multiple regression analysis showed that the L10 allele was significantly associated with a reduced risk of CAD (p = 0.049, OR = 0.51[0.26-1.00]), and with its reduced severity (p = 0.045, OR = 0.44[0.20-0.98]). The L10 allele is associated with a reduced risk and severity of CAD, seemingly independently of its LDL-lowering effect, suggesting a direct effect of PCSK9 on atherogenesis.

  12. Crystal structure of (1S,3R,8R,9R)-2,2-di-chloro-3,7,7-tri-methyl-10-methylenetri-cyclo-[6.4.0.0(1,3)]dodecan-9-ol.

    PubMed

    Benzalim, Ahmed; Auhmani, Aziz; Bimoussa, Abdoullah; Ait Itto, My Youssef; Daran, Jean-Claude; Auhmani, Abdelwahed

    2016-08-01

    The title compound, C16H24Cl2O, was synthesized by treating (1S,3R,8S,9R,10S)-2,2-di-chloro-3,7,7,10-tetra-methyl-9,10-ep-oxy-tri-cyclo-[6.4.0.0(1,3)]dodecane with a concentrated solution of hydro-bromic acid. It is built up from three fused rings: a cyclo-heptane ring, a cyclo-hexyl ring bearing alkene and hy-droxy substituents, and a cyclo-propane ring bearing two chlorine atoms. The asymmetric unit contains two mol-ecules linked by an O-H⋯O hydrogen bond. In the crystal, further O-H⋯O hydrogen bonds build up an R 4 (4)(8) cyclic tetra-mer. One of the mol-ecules presents disorder that affects the seven-membered ring. In both mol-ecules, the six-membered rings display a chair conformation, whereas the seven-membered rings display conformations inter-mediate between boat and twist-boat for the non-disordered mol-ecule and either a chair or boat and twist-boat for the disordered mol-ecule owing to the disorder. The absolute configuration for both mol-ecules is 1S,3R,8R,9R and was deduced from the chemical pathway and further confirmed by the X-ray structural analysis. PMID:27536404

  13. Experimental and computer graphics simulation analyses of the DNA interaction of 1,8-bis-(2-diethylaminoethylamino)-anthracene-9,10-dione, a compound modelled on doxorubicin.

    PubMed

    Islam, S A; Neidle, S; Gandecha, B M; Brown, J R

    1983-09-15

    The crystal structure of the anthraquinone derivative 1,8-bis-(2-diethylaminoethylamino)-anthracene-9,10-dione has been established. This compound was prepared as a potential DNA-intercalating agent based on the proven intercalators doxorubicin and mitoxantrone. Its DNA-binding properties have been examined experimentally by spectroscopic, thermal denaturation and ccc-DNA unwinding techniques: the results are consistent with an intercalative mode of binding to DNA. Computer graphics stimulation of the intercalative docking of this compound into the self-complementary dimer of d(CpG) has provided a minimum energy geometrical arrangement for the bound drug in the intercalation site comparable to that for proflavine when intercalated into the same d(CpG) model system. Entry of the compound into the site can only occur via the major groove.

  14. Magmatic lineations inferred from anisotropy of magnetic susceptibility fabrics in Units 8, 9, and 10 of the Rum Eastern Layered Series, NW Scotland

    NASA Astrophysics Data System (ADS)

    O'Driscoll, B.; Hargraves, R. B.; Emeleus, C. H.; Troll, V. R.; Donaldson, C. H.; Reavy, R. J.

    2007-10-01

    The Eastern Layered Series of the Rum Layered Suite, NW Scotland, comprises a sequence of sixteen (30-150 m thick) cyclic units. The upper troctolite-olivine gabbro parts of each of these units exhibit small-scale modal layering and a pervasive, layer-parallel mineral lamination that is often associated with 'soft-sediment' deformation structures. A sporadic, macroscopic magmatic lineation measurable on mineral lamination surfaces is also observed in places. Anisotropy of magnetic susceptibility (AMS) fabrics were studied in three of these cyclic units, (8, 9, and 10) in the northern part of the Eastern Layered Series. Magnetic fabrics measured in the troctolites and gabbros yield one dominant trend in which magnetic foliations parallel magmatic layering and magnetic lineations trend NW-SE and plunge gently. Magnetic fabrics measured for two detailed traverses through Unit 10 on the northern side of Hallival also yield one dominant trend, similar to that measured elsewhere in the Eastern Layered Series. However, toward the centre of Unit 10 in each traverse, magnetic lineations sometimes plunge approximately downdip (SW) on the magnetic foliation planes. The implications of these results are discussed with reference to previous textural and fabric observations on Rum. A model is suggested in which weak linear arrangements of cumulus olivine and plagioclase crystals are developed due to slumping and soft-sediment deformation of unconsolidated crystal mushes during central sagging of the Rum Layered Suite.

  15. The z = 9-10 galaxy population in the Hubble Frontier Fields and CLASH surveys: the z = 9 luminosity function and further evidence for a smooth decline in ultraviolet luminosity density at z≥ 8

    NASA Astrophysics Data System (ADS)

    McLeod, D. J.; McLure, R. J.; Dunlop, J. S.

    2016-07-01

    We present the results of a search for z = 9-10 galaxies within the first eight pointings of the Hubble Frontier Fields (HFF) survey and 20 cluster fields from the Cluster Lensing And Supernova survey with Hubble (CLASH) survey. Combined with our previous analysis of the Hubble Ultra Deep Field, we have now completed a search for z = 9-10 galaxies over ≃ 130 arcmin2, spread across 29 Hubble Space Telescope Wide Field Camera 3/IR pointings. We confine our primary search for high-redshift candidates in this imaging to the uniformly deep, relatively low magnification regions (i.e. σ160 > 30 AB mag for HFF and σ160 > 28.8 AB mag for CLASH in 0.5-arcsec apertures). We unveil a sample of 33 galaxy candidates at zphot ≥ 8.4, five of which have primary photometric redshift solutions in the range 9.6 < zphot < 11.2. The improved statistics and reduced cosmic variance provided by our new sample allows a more accurate determination of the ultraviolet (UV)-selected galaxy luminosity function (LF) at z ≃ 9. Our new results strengthen our previous conclusion that the LF appears to evolve smoothly from z = 8 to 9, an evolution which can be equally well modelled by a factor of ≃ 2 drop in density, or a dimming of ≃ 0.5 mag in M⋆. Moreover, we are able to place initial constraints on the z = 10 LF, finding that the number density at M1500 ≃ -19.7 is log (φ ) = -4.1^{+0.2}_{-0.3}, a factor of ≃ 2 lower than at z = 9. Finally, we use our new results to revisit the issue of the decline in UV luminosity density (ρUV) at z ≥ 8. We conclude that the data continue to support a smooth decline in ρUV over the redshift interval 6 < z < 10, in agreement with simple models of early galaxy evolution driven by the growth in the underlying dark matter halo mass function.

  16. Excited-state intramolecular hydrogen transfer (ESIHT) of 1,8-dihydroxy-9,10-anthraquinone (DHAQ) characterized by ultrafast electronic and vibrational spectroscopy and computational modeling.

    PubMed

    Mohammed, Omar F; Xiao, Dequan; Batista, Victor S; Nibbering, Erik T J

    2014-05-01

    We combine ultrafast electronic and vibrational spectroscopy and computational modeling to investigate the photoinduced excited-state intramolecular hydrogen-transfer dynamics in 1,8-dihydroxy-9,10-anthraquinone (DHAQ) in tetrachloroethene, acetonitrile, dimethyl sulfoxide, and methanol. We analyze the electronic excited states of DHAQ with various possible hydrogen-bonding schemes and provide a general description of the electronic excited-state dynamics based on a systematic analysis of femtosecond UV/vis and UV/IR pump-probe spectroscopic data. Upon photoabsorption at 400 nm, the S2 electronic excited state is initially populated, followed by a rapid equilibration within 150 fs through population transfer to the S1 state where DHAQ exhibits ESIHT dynamics. In this equilibration process, the excited-state population is distributed between the 9,10-quinone (S2) and 1,10-quinone (S1) states while undergoing vibrational energy redistribution, vibrational cooling, and solvation dynamics on the 0.1-50 ps time scale. Transient UV/vis pump-probe data in methanol also suggest additional relaxation dynamics on the subnanosecond time scale, which we tentatively ascribe to hydrogen bond dynamics of DHAQ with the protic solvent, affecting the equilibrium population dynamics within the S2 and S1 electronic excited states. Ultimately, the two excited singlet states decay with a solvent-dependent time constant ranging from 139 to 210 ps. The concomitant electronic ground-state recovery is, however, only partial because a large fraction of the population relaxes to the first triplet state. From the similarity of the time scales involved, we conjecture that the solvent plays a crucial role in breaking the intramolecular hydrogen bond of DHAQ during the S2/S1 relaxation to either the ground or triplet state. PMID:24684387

  17. 9 CFR 203.8-203.9 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false 203.8-203.9 Section 203.8-203.9 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS ADMINISTRATION (PACKERS AND... ACT §§ 203.8-203.9...

  18. 9 CFR 203.8-203.9 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false 203.8-203.9 Section 203.8-203.9 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS ADMINISTRATION (PACKERS AND... ACT §§ 203.8-203.9...

  19. 9 CFR 203.8-203.9 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false 203.8-203.9 Section 203.8-203.9 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS ADMINISTRATION (PACKERS AND... ACT §§ 203.8-203.9...

  20. 9 CFR 203.8-203.9 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false 203.8-203.9 Section 203.8-203.9 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS ADMINISTRATION (PACKERS AND... ACT §§ 203.8-203.9...

  1. 9 CFR 203.8-203.9 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false 203.8-203.9 Section 203.8-203.9 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS ADMINISTRATION (PACKERS AND... ACT §§ 203.8-203.9...

  2. 49 CFR 8.9 - Information Security Review Committee.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false Information Security Review Committee. 8.9 Section 8.9 Transportation Office of the Secretary of Transportation CLASSIFIED INFORMATION: CLASSIFICATION/DECLASSIFICATION/ACCESS Classification/Declassification of Information § 8.9 Information Security Review Committee. (a) There is hereby established...

  3. 8 CFR 212.8-212.9 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false 212.8-212.9 Section 212.8-212.9 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS DOCUMENTARY REQUIREMENTS: NONIMMIGRANTS; WAIVERS; ADMISSION OF CERTAIN INADMISSIBLE ALIENS; PAROLE §§ 212.8-212.9...

  4. 8 CFR 212.8-212.9 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false 212.8-212.9 Section 212.8-212.9 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS DOCUMENTARY REQUIREMENTS: NONIMMIGRANTS; WAIVERS; ADMISSION OF CERTAIN INADMISSIBLE ALIENS; PAROLE §§ 212.8-212.9...

  5. Molecular analysis of exons 8, 9 and 10 of the fibroblast growth factor receptor 2 (FGFR2) gene in two families with index cases of Apert Syndrome

    PubMed Central

    Hernández, Gualberto; Barrera, Alejandro; Ospina, Sandra; Prada, Rolando

    2015-01-01

    Introduction: Apert syndrome (AS) is a craniosynostosis condition caused by mutations in the Fibroblast Growth Factor Receptor 2 (FGFR2) gene. Clinical features include cutaneous and osseous symmetric syndactily in hands and feet, with variable presentations in bones, brain, skin and other internal organs. Methods: Members of two families with an index case of Apert Syndrome were assessed to describe relevant clinical features and molecular analysis (sequencing and amplification) of exons 8, 9 and 10 of FGFR2 gen. Results: Family 1 consists of the mother, the index case and half -brother who has a cleft lip and palate. In this family we found a single FGFR2 mutation, S252W, in the sequence of exon 8. Although mutations were not found in the study of the patient affected with cleft lip and palate, it is known that these diseases share signaling pathways, allowing suspected alterations in shared genes. In the patient of family 2, we found a sequence variant T78.501A located near the splicing site, which could interfere in this process, and consequently with the protein function. PMID:26600631

  6. Uses of monoclonal antibody 8H9

    DOEpatents

    Cheung, Nai-Kong V.

    2010-06-22

    This invention provides a composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a suitable carrier. This invention provides a pharmaceutical composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a pharmaceutically acceptable carrier. This invention also provides an antibody other than the monoclonal antibody 8H9 comprising the complementary determining regions of monoclonal antibody 8H9 or a derivative thereof, capable of binding to the same antigen as the monoclonal antibody 8H9. This invention provides a substance capable of competitively inhibiting the binding of monoclonal antibody 8H9. This invention also provides an isolated scFv of monoclonal antibody 8H9 or a derivative thereof. This invention also provides the 8H9 antigen. This invention also provides different uses of the monoclonal antibody 8H9 or its derivative.

  7. Uses of monoclonal antibody 8H9

    DOEpatents

    Cheung, Nai-Kong V.

    2013-04-09

    This invention provides a composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a suitable carrier. This invention provides a pharmaceutical composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a pharmaceutically acceptable carrier. This invention also provides an antibody other than the monoclonal antibody 8H9 comprising the complementary determining regions of monoclonal antibody 8H9 or a derivative thereof, capable of binding to the same antigen as the monoclonal antibody 8H9. This invention provides a substance capable of competitively inhibiting the binding of monoclonal antibody 8H9. This invention also provides an isolated scFv of monoclonal antibody 8H9 or a derivative thereof. This invention also provides the 8H9 antigen. This invention also provides different uses of the monoclonal antibody 8H9 or its derivative.

  8. Reaction of benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide with human hemoglobin and chromatographic resolution of the covalent adducts

    SciTech Connect

    Haugen, D.A.; Myers, S.R.

    1990-01-01

    The formation of hemoglobin-carcinogen adducts has been proposed as a measure of human exposure to carcinogens. Hemoglobin-carcinogen adducts have been detected in carcinogen-treated animals and in human populations. Although polycyclic aromatic hydrocarbons (PAH) are ubiquitous in the human environment and DNA-PAH adducts have been detected in human tissues, the occurrent of hemoglobin-PAH adducts in humans has not been described. In this study we examined the effects of reaction conditions on the extent of in vitro reaction of human hemoglobin and (+)(anti)-({sup 3}H)benzo(a)pyrene-7,8-diol-9,10-epoxide (BPDE), a metabolite largely responsible for the carcinogenic effect of benzo(a)pyrene. The chromatographic properties of the resulting hemoglobin-BPDE adducts were examined by conventional DEAE-cellulose ion-exchange liquid chromatography and by reversed-phase high-performance liquid chromatography. Several adducts were chromatographically resolved from hemoglobin and from the individual globins.

  9. Characterization of the Neurospora crassa Cell Fusion Proteins, HAM-6, HAM-7, HAM-8, HAM-9, HAM-10, AMPH-1 and WHI-2

    PubMed Central

    Fu, Ci; Ao, Jie; Dettmann, Anne; Seiler, Stephan; Free, Stephen J.

    2014-01-01

    Intercellular communication of vegetative cells and their subsequent cell fusion is vital for different aspects of growth, fitness, and differentiation of filamentous fungi. Cell fusion between germinating spores is important for early colony establishment, while hyphal fusion in the mature colony facilitates the movement of resources and organelles throughout an established colony. Approximately 50 proteins have been shown to be important for somatic cell-cell communication and fusion in the model filamentous fungus Neurospora crassa. Genetic, biochemical, and microscopic techniques were used to characterize the functions of seven previously poorly characterized cell fusion proteins. HAM-6, HAM-7 and HAM-8 share functional characteristics and are proposed to function in the same signaling network. Our data suggest that these proteins may form a sensor complex at the cell wall/plasma membrane for the MAK-1 cell wall integrity mitogen-activated protein kinase (MAPK) pathway. We also demonstrate that HAM-9, HAM-10, AMPH-1 and WHI-2 have more general functions and are required for normal growth and development. The activation status of the MAK-1 and MAK-2 MAPK pathways are altered in mutants lacking these proteins. We propose that these proteins may function to coordinate the activities of the two MAPK modules with other signaling pathways during cell fusion. PMID:25279949

  10. 22 CFR 9.8 - Classification challenges.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Classification challenges. 9.8 Section 9.8 Foreign Relations DEPARTMENT OF STATE GENERAL SECURITY INFORMATION REGULATIONS § 9.8 Classification... classification status is improper are expected and encouraged to challenge the classification status of...

  11. 22 CFR 9.8 - Classification challenges.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Classification challenges. 9.8 Section 9.8 Foreign Relations DEPARTMENT OF STATE GENERAL SECURITY INFORMATION REGULATIONS § 9.8 Classification... classification status is improper are expected and encouraged to challenge the classification status of...

  12. 22 CFR 9.8 - Classification challenges.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Classification challenges. 9.8 Section 9.8 Foreign Relations DEPARTMENT OF STATE GENERAL SECURITY INFORMATION REGULATIONS § 9.8 Classification... classification status is improper are expected and encouraged to challenge the classification status of...

  13. 22 CFR 9.8 - Classification challenges.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Classification challenges. 9.8 Section 9.8 Foreign Relations DEPARTMENT OF STATE GENERAL SECURITY INFORMATION REGULATIONS § 9.8 Classification... classification status is improper are expected and encouraged to challenge the classification status of...

  14. 31 CFR 9.8 - Emergency action.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Emergency action. 9.8 Section 9.8 Money and Finance: Treasury Office of the Secretary of the Treasury EFFECTS OF IMPORTED ARTICLES ON THE NATIONAL SECURITY § 9.8 Emergency action. In emergency situations or when in his judgment national...

  15. 32 CFR 9.8 - Authority.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Authority. 9.8 Section 9.8 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS PROCEDURES FOR TRIALS BY MILITARY COMMISSIONS OF CERTAIN NON-UNITED STATES CITIZENS IN THE WAR AGAINST TERRORISM § 9.8...

  16. 22 CFR 9.8 - Classification challenges.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Classification challenges. 9.8 Section 9.8 Foreign Relations DEPARTMENT OF STATE GENERAL SECURITY INFORMATION REGULATIONS § 9.8 Classification... classification status is improper are expected and encouraged to challenge the classification status of...

  17. Translation of satellite tobacco necrosis virus RNA modified by (not equal to)-r-7,t-8-dihydroxy-t-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene is inhibited in a wheat germ cell-free system

    SciTech Connect

    Haas, R.; Pulkrabek, P.; Takanami, Y.; Grunberger, D.

    1983-01-01

    It has been shown that (not equal to)-r-7-,t-8-dihydroxy-t-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (BPDE) modification of rabbit globin mRNA results in inhibition of translational initiation. In order to explore the possibility that modification of the 5' cap structure was responsible for this inhibition, the naturally non-capped mRNA from satellite tobacco necrosis virus (STNV) was reacted with BPDE and translated in a wheat germ cell-free system. The extent of modification was 1.3 and 2.9 BPDE residues/molecule. High performance liquid chromatography of the modified nucleosides from enzymatically hydrolyzed STNV RNA revealed that greater than 90% of the nucleoside adducts were substituted at the exocyclic amino group of guanosine. The translational ability of the lower and higher modified STNV, measured by incorporation of (/sup 14/C)amino acids into acid-precipitable polypeptides is inhibited by 55% and 63%, respectively. Polyacrylamide gel electrophoretic analyses of the translation products indicate that predominantly full-length coat proteins are synthesized but with the carcinogen-modified STNV the amount is reduced. On the other hand, 80S initiation complex formation is not inhibited as measured by binding of the BPDE-modified STNV to ribosomes and followed by glycerol gradient centrifugation. Under these conditions, aurintricarboxylic acid completely inhibits 80S initiation complex formation in the presence of either modified or native STNV. These results suggest that inhibition of in vitro translation of BPDE-modified STNV, in contrast to that of globin mRNA, is not at the level of initiation complex formation but possibly by premature termination of growing polypeptides.

  18. Thermodynamic and biodistribution studies of Zn(II), Ca(II), Gd(III) and Cu(II) complexes of 3,3,9,9-tetramethyl-4,8-diazaundecane-2,10-dione dioxime.

    PubMed

    Nomkoko, Thembelani E; Jackson, Graham E; Nakani, Bandile S; Louw, Werner K A; Zeevaart, Jan R

    2004-03-01

    The thermodynamic equilibria of copper(II), zinc(II), calcium(II) and gadolinium(III) with 3,3,9,9-tetramethyl-4,8-diazaundecane-2,10-dione dioxime (L1) have been studied at 25 degrees C and an ionic strength of 0.15 mol dm(-3). Copper and gadolinium form stable complexes with the ligand while the corresponding zinc species are more than 9 log units less stable. No complexes between calcium and the ligand were detected. The low binding strength of L1 towards zinc is attributed to the square-planar coordination geometry forced on the metal ion by the ligand as revealed by molecular mechanics calculations and molecular dynamics simulations. Speciation calculations, using a computer model of blood plasma, indicate that, despite the high concentration of zinc(II) and calcium(II) in vivo, L1 is able to increase the low-molecular-mass fraction of copper in plasma. Octanol/water partition coefficient of [CuL1H(-1)] indicates that although this species is largely hydrophilic, approximately 6% of the complex goes into the octanol phase and hence may promote dermal absorption of copper by the same amount. The dermal penetration rate is calculated to be 4.0 x 10(-4) mm h(-1). The [CuL1H(-1)] complex, which predominates at pH 7.4, is a poor mimic of native copper-zinc superoxide dismutase. Biodistribution experiments using the 64Cu-labelled [CuL1H(-1)] complex indicate an initial high uptake of this species in the liver followed by redistribution into muscle. Only a small amount is excreted through the urine.

  19. Uses of monoclonal antibody 8H9

    DOEpatents

    Cheung, Nai-Kong V.

    2010-06-15

    This invention provides a composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a suitable carrier. This invention provides a pharmaceutical composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a pharmaceutically acceptable carrier. This invention also provides an antibody other than the monoclonal antibody 8H9 comprising the complementary determining regions of monoclonal antibody 8H9 or a derivative thereof, capable of binding to the same antigen as the monoclonal antibody 8H9. This invention provides a substance capable of competitively inhibiting the binding of monoclonal antibody 8H9. This invention also provides an isolated scFv of monoclonal antibody 8H9 or a derivative thereof. This invention also provides the 8H9 antigen. This invention also provides a method of inhibiting the growth of tumor cells comprising contacting said tumor cells with an appropriate amount of monoclonal antibody 8H9 or a derivative thereof.

  20. Uses of monoclonal antibody 8H9

    DOEpatents

    Cheung, Nai-Kong V

    2013-08-06

    This invention provides a composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a suitable carrier. This invention provides a pharmaceutical composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a pharmaceutically acceptable carrier. This invention also provides an antibody other than the monoclonal antibody 8H9 comprising the complementary determining regions of monoclonal antibody 8H9 or a derivative thereof, capable of binding to the same antigen as the monoclonal antibody 8H9. This invention provides a substance capable of competitively inhibiting the binding of monoclonal antibody 8H9. This invention also provides an isolated scFv of monoclonal antibody 8H9 or a derivative thereof. This invention also provides the 8H9 antigen. This invention also provides a method of inhibiting the growth of tumor cells comprising contacting said tumor cells with an appropriate amount of monoclonal antibody 8H9 or a derivative thereof.

  1. Microwave-induced synthesis and anti-microbial activities of 7,10,11,12-tetrahydrobenzo[c]acridin-8(9H)-one derivatives.

    PubMed

    Nadaraj, Vetrivel; Selvi, Senniappan Thamarai; Mohan, Sellappan

    2009-03-01

    Some new substituted tetrahydroacridin-8-ones and diverse derivatives were synthesized by uncatalysed multi-component reaction of dimedone or cyclohexan-1,3-dione, alpha-naphthylamine and various (o,p,m)-substituted benzaldehydes. The in vitro anti-microbial activities of the prepared compounds were evaluated against some bacteria and fungi strains. The results suggested that, the products 2a-g and 4a-g exhibited good inhibitory effect against most of the tested organisms. Especially, 2f, 2g, 4f and 4g were shown to be most effective against Rhodotorula rubra and Aspergillus parasiticus and compounds 2a, 2c, 2g, 4f and 4g proved to be effective with MIC values in the range of 3.9-7.8 microg/ml. PMID:18718695

  2. Dual fluorescence from an isonido ReIII rhenacarborane phosphine complex, [7,10-mu-H-7-CO-7,7-(PPh3)2-isonido-7,8,9-ReC2B7H9].

    PubMed

    Buckner, Steven W; Fischer, Matthew J; Jelliss, Paul A; Luo, Rensheng; Minteer, Shelley D; Rath, Nigam P; Siemiarczuk, Aleksander

    2006-09-01

    The complex [7,10-mu-H-7-CO-7,7-(PPh3)2-isonido-7,8,9-ReC2B7H9] has been synthesized by treatment of the complex salt [NHMe3][3,3-Cl2-3,3-(CO)2-closo-3,1,2-ReC2B9H11] with PPh3 in refluxing THF (tetrahydrofuran) and isolated as intensely colored orange-red microcrystals. Spectroscopic NMR and IR data have suggested that the product has a highly asymmetric structure with two inequivalent PPh3 ligands and a single CO ligand. Measurement of 11B NMR spectra in particular have indicated seven distinct boron vertexes, although the resulting cage degradation by removal of two BH vertexes was confirmed only following X-ray crystallographic analysis, which revealed the pentadecahedral isonido-7,8,9-ReC2B7 architecture. The 11B NMR resonances span an enormous chemical shift range (Deltadelta = 113), and this appears to be a direct consequence of the deshielding of the boron vertex directly opposite the quadrilateral |ReCCB| aperture. The new complex has been shown by electrochemical measurements to undergo a reversible one-electron oxidation. Digitally simulated cyclic voltammograms support a proposed square scheme (E(1/2) = 0.58, 0.69 V vs ferrocene) involving a reversible isonido-closo transition of the metallacarborane cage. Most unusually for a metallacarborane complex, ambient temperature solutions in CH2Cl2 and DMF have been shown to be intensely turquoise-blue fluorescent (lambda(em) = 442 nm, Phi = 0.012). Fluorescence spectroscopy measurements in MeTHF (2-methyltetrahydrofuran) glass at 77 K have indicated that the likely cause of such a broad emission is dual fluorescence (lambda(em) = 404, 505 nm), with both emissions displaying vibronic structure. Following excited-state lifetime decay analysis, the emissive behavior has been accredited to metal-perturbed 1IL states, with the lower energy emission arising from a slight geometric distortion of the initially excited complex.

  3. Anticonvulsant Profiles of Certain New 6-Aryl-9-substituted-6,9-diazaspiro-[4.5]decane-8,10-diones and 1-Aryl-4-substituted-1,4-diazaspiro[5.5]undecane-3,5-diones

    PubMed Central

    Aboul-Enein, Mohamed N.; El-Azzouny, Aida A.; Attia, Mohamed I.; Maklad, Yousreya A.; Aboutabl, Mona E.; Ragab, Fatma; El-Hamid, Walaa H. A. Abd

    2014-01-01

    Synthesis and anticonvulsant potential of certain new 6-aryl-9-substituted-6,9-diazaspiro[4.5]decane-8,10-diones (6a–l) and 1-aryl-4-substituted-1,4-diazaspiro[5.5]undecane-3,5-diones (6m–x) are reported. The intermediates 1-[(aryl)(cyanomethyl)amino]cycloalkanecarboxamides (3a–f) were prepared via adopting Strecker synthesis on the proper cycloalkanone followed by partial hydrolysis of the obtained nitrile functionality and subsequent N-cyanomethylation. Compounds 3a–f were subjected to complete nitrile hydrolysis to give the respective carboxylic acid derivatives 4a–f which were cyclized under mild conditions to give the spiro compounds 5a–f. Ultimately, compounds 5a–f were alkylated or aralkylated to give the target compounds 6a–i and 6m–u. On the other hand, compounds 6j–l and 6v–x were synthesized from the intermediates 5a–f through alkylation, dehydration and finally tetrazole ring formation. Anticonvulsant screening of the target compounds 6a–x revealed that compound 6g showed an ED50 of 0.0043 mmol/kg in the scPTZ screen, being about 14 and 214 fold more potent than the reference drugs, Phenobarbital (ED50 = 0.06 mmol/kg) and Ethosuximide (ED50 = 0.92 mmol/kg), respectively. Compound 6e exhibited an ED50 of 0.019 mmol/kg, being about 1.8 fold more potent than that of the reference drug, Diphenylhydantoin (ED50 = 0.034 mmol/kg) in the MES screen. Interestingly, all the test compounds 6a–x did not show any minimal motor impairment at the maximum administered dose in the neurotoxicity screen. PMID:25250910

  4. 49 CFR 8.9 - Information Security Review Committee.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Information Security Review Committee. 8.9 Section.../DECLASSIFICATION/ACCESS Classification/Declassification of Information § 8.9 Information Security Review Committee. (a) There is hereby established a Department of Transportation Information Security Review...

  5. 49 CFR 8.9 - Information Security Review Committee.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Information Security Review Committee. 8.9 Section.../DECLASSIFICATION/ACCESS Classification/Declassification of Information § 8.9 Information Security Review Committee. (a) There is hereby established a Department of Transportation Information Security Review...

  6. 1 CFR 8.9 - Form of citation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... section, and the short form “CFR” may be used for “Code of Federal Regulations.” For example, “1 CFR 10.2” refers to title 1, Code of Federal Regulations, part 10, section 2. ... 1 General Provisions 1 2012-01-01 2012-01-01 false Form of citation. 8.9 Section 8.9...

  7. 1 CFR 8.9 - Form of citation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... section, and the short form “CFR” may be used for “Code of Federal Regulations.” For example, “1 CFR 10.2” refers to title 1, Code of Federal Regulations, part 10, section 2. ... 1 General Provisions 1 2013-01-01 2012-01-01 true Form of citation. 8.9 Section 8.9...

  8. 1 CFR 8.9 - Form of citation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... section, and the short form “CFR” may be used for “Code of Federal Regulations.” For example, “1 CFR 10.2” refers to title 1, Code of Federal Regulations, part 10, section 2. ... 1 General Provisions 1 2014-01-01 2012-01-01 true Form of citation. 8.9 Section 8.9...

  9. 1 CFR 8.9 - Form of citation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... section, and the short form “CFR” may be used for “Code of Federal Regulations.” For example, “1 CFR 10.2” refers to title 1, Code of Federal Regulations, part 10, section 2. ... 1 General Provisions 1 2011-01-01 2011-01-01 false Form of citation. 8.9 Section 8.9...

  10. 1 CFR 8.9 - Form of citation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... section, and the short form “CFR” may be used for “Code of Federal Regulations.” For example, “1 CFR 10.2” refers to title 1, Code of Federal Regulations, part 10, section 2. ... 1 General Provisions 1 2010-01-01 2010-01-01 false Form of citation. 8.9 Section 8.9...

  11. 8 CFR 244.9 - Evidence.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Evidence. 244.9 Section 244.9 Aliens and... OF DESIGNATED STATES § 244.9 Evidence. (a) Documentation. Applicants shall submit all documentation... affidavit or other credible evidence may be submitted. (1) Evidence of identity and nationality....

  12. 8 CFR 1244.9 - Evidence.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Evidence. 1244.9 Section 1244.9 Aliens and... PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 1244.9 Evidence. (a) Documentation. Applicants shall... document is unavailable, an affidavit or other credible evidence may be submitted. (1) Evidence of...

  13. 8 CFR 244.9 - Evidence.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Evidence. 244.9 Section 244.9 Aliens and... OF DESIGNATED STATES § 244.9 Evidence. (a) Documentation. Applicants shall submit all documentation... affidavit or other credible evidence may be submitted. (1) Evidence of identity and nationality....

  14. 9 CFR 91.8 - Sheep.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...-positive animal or an exposed animal, as defined in 9 CFR parts 54 and 79, or if it has ever been in an infected flock, source flock, or trace flock, as defined in 9 CFR parts 54 and 79; or if it is the progeny... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Sheep. 91.8 Section 91.8 Animals...

  15. 9 CFR 91.8 - Sheep.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...-positive animal or an exposed animal, as defined in 9 CFR parts 54 and 79, or if it has ever been in an infected flock, source flock, or trace flock, as defined in 9 CFR parts 54 and 79; or if it is the progeny... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Sheep. 91.8 Section 91.8 Animals...

  16. 9 CFR 91.8 - Sheep.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...-positive animal or an exposed animal, as defined in 9 CFR parts 54 and 79, or if it has ever been in an infected flock, source flock, or trace flock, as defined in 9 CFR parts 54 and 79; or if it is the progeny... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Sheep. 91.8 Section 91.8 Animals...

  17. 9 CFR 91.8 - Sheep.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...-positive animal or an exposed animal, as defined in 9 CFR parts 54 and 79, or if it has ever been in an infected flock, source flock, or trace flock, as defined in 9 CFR parts 54 and 79; or if it is the progeny... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Sheep. 91.8 Section 91.8 Animals...

  18. 9 CFR 91.8 - Sheep.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...-positive animal or an exposed animal, as defined in 9 CFR parts 54 and 79, or if it has ever been in an infected flock, source flock, or trace flock, as defined in 9 CFR parts 54 and 79; or if it is the progeny... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Sheep. 91.8 Section 91.8 Animals...

  19. A Cultural Resources Inventory and Historical Evaluation of the Smoky Atmospheric Nuclear Test, Areas 8, 9, and 10, Nevada National Security Site, Nye County, Nevada

    SciTech Connect

    Jones, Robert C.; King, Maureen L.; Beck, Colleen M.; Falvey, Lauren W.; Menocal, Tatianna M.

    2014-09-01

    This report presents the results of a National Historic Preservation Act Section 106 cultural resources inventory and historical evaluation of the 1957 Smoky atmospheric test location on the Nevada National Security Site (NNSS). The Desert Research Institute (DRI) was tasked to conduct a cultural resources study of the Smoky test area as a result of a proposed undertaking by the Department of Energy Environmental Management. This undertaking involves investigating Corrective Action Unit (CAU) 550 for potential contaminants of concern as delineated in a Corrective Action Investigation Plan. CAU 550 is an area that spatially overlaps portions of the Smoky test location. Smoky, T-2c, was a 44 kt atmospheric nuclear test detonated at 5:30 am on August 31, 1957, on top of a 213.4 m (700 ft) 200 ton tower (T-2c) in Area 8 of the NNSS. Smoky was a weapons related test of the Plumbbob series (number 19) and part of the Department of Defense Exercise Desert Rock VII and VIII. The cultural resources effort involved the development of a historic context based on archival documents and engineering records, the inventory of the cultural resources in the Smoky test area and an associated military trench location in Areas 9 and 10, and an evaluation of the National Register eligibility of the cultural resources. The inventory of the Smoky test area resulted in the identification of structures, features, and artifacts related to the physical development of the test location and the post-test remains. The Smoky test area was designated historic district D104 and coincides with a historic archaeological site recorded as 26NY14794 and the military trenches designed for troop observation, site 26NY14795. Sites 26NY14794 and 26NY14795 are spatially discrete with the trenches located 4.3 km (2.7 mi) southeast of the Smoky ground zero. As a result, historic district D104 is discontiguous and in total it covers 151.4 hectares (374 acres). The Smoky test location, recorded as historic

  20. Crystal structure of (9S,10S)-10-eth­oxy-9-hy­droxy-6,6,9-trimethyl-3-pentyl-7,8,9,10-tetra­hydro-6H-benzo[c]chromen-1-yl 4-methyl­benzene­sulfonate

    PubMed Central

    Gul, Waseem; Galal, Ahmed; ElSohly, Mahmoud A.; Carvalho, Paulo

    2015-01-01

    In the structure of the title compound, C30H40O6S, the cyclo­hexene and heterocyclic rings are linked by a double bond. The cyclo­hexene ring has a half-chair conformation (the methyl­ene group adjacent to the hy­droxy substituent lies above the remaining atoms) and the hy­droxy and eth­oxy groups have equatorial and bis­ectional dispositions, respectively. The heterocyclic ring has an envelope conformation (with the CMe2 C atom being the flap). The dihedral angle between the aromatic rings is 53.88 (10)°. A long intra­molecular C—H⋯S inter­action is noted. In the mol­ecular packing, hy­droxy-O—H⋯O(sulfonate) hydrogen bonds lead to a helical chain along [010]. Connections between chains are of the type methyl-C—H⋯O(sulfonate) and lead to supra­molecular layers that lie parallel to (001). The studied crystal was an inversion twin. PMID:26870509

  1. 46 CFR 9.10 - Waiting time.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Waiting time. 9.10 Section 9.10 Shipping COAST GUARD... § 9.10 Waiting time. The same construction should be given the act when charging for waiting time as... for duty the waiting time amounts to at least one hour....

  2. 46 CFR 9.10 - Waiting time.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Waiting time. 9.10 Section 9.10 Shipping COAST GUARD... § 9.10 Waiting time. The same construction should be given the act when charging for waiting time as... for duty the waiting time amounts to at least one hour....

  3. 46 CFR 9.10 - Waiting time.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Waiting time. 9.10 Section 9.10 Shipping COAST GUARD... § 9.10 Waiting time. The same construction should be given the act when charging for waiting time as... for duty the waiting time amounts to at least one hour....

  4. 8. Historic view, Pier 9. Plan of deck and pilings, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Historic view, Pier 9. Plan of deck and pilings, 1932. Photographic copy of original. Boston National Historical Park Archives, Charlestown Navy Yard. - Charlestown Navy Yard, Pier 9, Between Piers 8 & 10, along Mystic River on Charlestown Waterfront at eastern edge of Navy Yard, Boston, Suffolk County, MA

  5. 9 CFR 104.8 - Illegal shipments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Illegal shipments. 104.8 Section 104.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS PERMITS FOR BIOLOGICAL PRODUCTS §...

  6. 9 CFR 104.8 - Illegal shipments.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Illegal shipments. 104.8 Section 104.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS PERMITS FOR BIOLOGICAL PRODUCTS §...

  7. 9 CFR 104.8 - Illegal shipments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Illegal shipments. 104.8 Section 104.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS PERMITS FOR BIOLOGICAL PRODUCTS §...

  8. 9 CFR 104.8 - Illegal shipments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Illegal shipments. 104.8 Section 104.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS PERMITS FOR BIOLOGICAL PRODUCTS §...

  9. 9 CFR 332.8 - Quarterly reports.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Quarterly reports. 332.8 Section 332.8 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION...

  10. 9 CFR 332.8 - Quarterly reports.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Quarterly reports. 332.8 Section 332.8 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION...

  11. 9 CFR 355.8 - Official number.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Official number. 355.8 Section 355.8 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... CERTIFICATION CERTIFIED PRODUCTS FOR DOGS, CATS, AND OTHER CARNIVORA; INSPECTION, CERTIFICATION,...

  12. 9 CFR 355.8 - Official number.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Official number. 355.8 Section 355.8 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... CERTIFICATION CERTIFIED PRODUCTS FOR DOGS, CATS, AND OTHER CARNIVORA; INSPECTION, CERTIFICATION,...

  13. 9 CFR 355.8 - Official number.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Official number. 355.8 Section 355.8 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... CERTIFICATION CERTIFIED PRODUCTS FOR DOGS, CATS, AND OTHER CARNIVORA; INSPECTION, CERTIFICATION,...

  14. 9 CFR 355.8 - Official number.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Official number. 355.8 Section 355.8 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... CERTIFICATION CERTIFIED PRODUCTS FOR DOGS, CATS, AND OTHER CARNIVORA; INSPECTION, CERTIFICATION,...

  15. Stable ion study of benzo[a]pyrene (BaP) derivatives: 7,8-dihydro-BaP, 9,10-dihydro-BaP and its 6-halo derivatives, 1- and 3-methoxy-9,10-dihydro-BaP-7(8H)-one, as well as the proximate carcinogen BaP 7,8-dihydrodiol and its dibenzoate, combined with a comparative DNA binding study of regioisomeric (1-, 4-, 2-) pyrenylcarbinols.

    PubMed

    Okazaki, Takao; Laali, Kenneth K; Zajc, Barbara; Lakshman, Mahesh K; Kumar, Subodh; Baird, William M; Dashwood, Wan-Mohaiza

    2003-05-01

    A stable ion study of a series of BaP derivatives is reported. 7,8-Dihydro-BaP 1 gives a persistent bay-region benzyliclike carbocation which shows extensive charge delocalization into the pyrene moiety. In contrast, a "benzylic" carbocation can not be generated from 9,10-dihydro-BaP 2. Introduction of bulky substituents at peri C-6 of 9,10-dihydro-BaP (as in 4 and 5) prevents side reactions (dimerization) to the extent that the initially formed carbocation undergoes rearrangement to generate the corresponding bay-region "benzylic" carbocation as a persistent species. Introduction of methoxy substituents into the 1- or 3-positions of 9,10-dihydro-BaP-7(8H)-one (6,7) increases its electrophilic reactivity to the extent that stable carboxonium-arenium dications are produced in FSO3H-SO2ClF. A detailed NMR study (at 500 MHz) of the resulting mono- and dications is reported, and charge delocalization mode (as well as conformational aspects) are addressed. Other oxidized derivatives of BaP such as the 7,8-dihydrodiol 9 and the 7,8-dihydrodibenzoate 8 are not suitable models for stable ion study because of competing O-protonation (and elimination). Energies for various possible arenium ions and regioisomeric "benzylic" cations were computed by the DFT method at the B3LYP/6-31G(d)//B3LYP/6-31G(d) level or by AM1 for comparison with the experimental results. These findings provide further evidence in support of the stability sequence: 1-pyrenyl > 4-pyrenyl > 2-pyrenyl in alpha-pyrene-substituted carbocations as models for the intermediates arising from BaP-epoxide ring opening. In an effort to provide a parallel, a series of alpha-pyrenylcarbinols were subjected to a DNA binding study using human MCF-7 cells. The results/trends are discussed and compared with the stable ion data.

  16. Synthesis, Cytotoxic and Contraceptive Activity of 6,8,9-Trihydroxy-2-methyl-2H-naphtho[2,3-b]pyran-5,10-dione, a Pigment of Echinothrix diadema, and its Analogs.

    PubMed

    Pokhilo, Natalia D; Melman, Galina I; Kiseleva, Marina I; Denisenko, Vladimir A; Anufriev, Victor Ph

    2015-07-01

    6,8,9-Trihydroxy-2-methyl-2H-naphtho[2,3-b]pyran-5,10-dion, a pigment of the sea urchin Echinothrix diadema, and six analogs were synthesized. The cytotoxic activity and contraceptive properties of the synthesized pyranonaphthazarins have been investigated using the sperm and eggs of the sea urchin Strongylocentrotus intermedius.

  17. 10 CFR 9.95 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Specific exemptions. 9.95 Section 9.95 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS Privacy Act Regulations Exemptions § 9.95 Specific exemptions....gov....

  18. 10 CFR 9.95 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Specific exemptions. 9.95 Section 9.95 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS Privacy Act Regulations Exemptions § 9.95 Specific exemptions....gov....

  19. Theoretical exploration of the nanoscale host-guest interactions between [n]cycloparaphenylenes (n = 10, 8 and 9) and fullerene C₆₀: from single- to three-potential well.

    PubMed

    Yuan, Kun; Zhou, Cai-Hua; Zhu, Yuan-Cheng; Zhao, Xiang

    2015-07-28

    The nanoscale host-guest interactions between [n]cycloparaphenylene ([n]CPP; n = 10, 8 and 9) nano-ring and fullerene C60 were explored theoretically. It is found that relatively small variations in the sizes of the [n]CPP host lead to very significant changes in encapsulation property toward the fullerene C60 guest. Expectedly, one stable inclusion-configuration of [10]CPP⊃C60 and one floating-configuration of [8]CPP⊃C60 are located on the potential surfaces of the two complexes, respectively. Unexpectedly, besides a floating-configuration (F-[9]CPP⊃C60), another stable inclusion-configuration (I-[9]CPP⊃C60) is also located on the potential surface of [9]CPP⊃C60 host-guest complex. Interaction energies and natural steric analysis show that these complexes are stabilized by balancing concave-convex π-π attractive and steric repulsive host-guest interactions. In contrast, the steric repulsive energy (Es) between host and guest of I-[9]CPP⊃C60 is as high as 233.12 kJ mol(-1), which is much larger than those in other complexes. The movements of C60 guest through the cavities of [n]CPP host (n = 10, 8 and 9) are simulated by calculating the energy profile, and the results interestingly reveal that the encapsulation of C60 by [10]CPP is in the manner of a single-potential well, by [8]CPP in the manner of a double-potential well, and by [9]CPP in the special manner of a three-potential well. We predict that the movement of C60 guest through the cavity of [9]CPP host should be experimentally observable owing to the relatively low energy barrier (<50 kJ mol(-1), M06-2X/6-31G(d)). Charge population analysis shows that an obvious charge transfer between host and guest takes place during the formation of I-[9]CPP⊃C60, which is different from those during the formation of [8]CPP⊃C60, [10]CPP⊃C60 and F-[9]CPP⊃C60. Additionally, the host-guest interaction regions were detected and visualized in real space based on the electron density and reduced density

  20. Phylogenetic Analysis and Pathogenicity Assessment of Two Strains of Avian Influenza Virus Subtype H9N2 Isolated from Migratory Birds: High Homology of Internal Genes with Human H10N8 Virus.

    PubMed

    Ye, Ge; Liang, Chai Hong; Hua, Deng Guo; Song, Lei Yong; Xiang, Yang Guo; Guang, Chen; Lan, Chen Hua; Ping, Hua Yu

    2016-01-01

    Two human-infecting avian influenza viruses (AIVs), H7N9 and H10N8, have emerged in China, which further indicate that the H9N2 subtype of AIVs, as an internal gene donor, may have an important role in the generation of new viruses with cross-species transmissibility and pathogenicity. H9N2 viruses that contain such internal genes widely exist in poultry but are rarely reported in migratory birds. In this study, two strains of the H9N2 virus were isolated from fecal samples of migratory birds in 2014: one strain from Caizi Lake in Anhui Province and one from Chen Lake in Hubei Province of China. Nucleotide sequence analysis revealed high homology of all six internal genes of these two strains with the internal genes of the human H10N8 virus in Jiangxi Province, as well as with the human H7N9 virus. Phylogenetic analysis indicated a possible origin of these two strains from poultry in South China. Both of the two viruses tested could replicated in respiratory organs of infective mice without adaption, by both strains of the H9N2 AIVs from wild birds, suggesting their potential capacity for directly infecting mammals. Our findings indicate the existence of H9N2 viruses that contain internal genes highly homologous with human H10N8 or H7N9 viruses. Wild birds can contribute to the spread of the H9N2 virus that contains the "harmful" internal gene complex, leading to gene rearrangement with other influenza viruses and to the generation of new pathogenic viruses. Therefore, strengthening AIV surveillance in wild birds can promote an understanding of the presence and prevalence of viruses and provide scientific evidence for the prevention and control of AIVs and human-infecting AIVs. PMID:26973600

  1. Phylogenetic Analysis and Pathogenicity Assessment of Two Strains of Avian Influenza Virus Subtype H9N2 Isolated from Migratory Birds: High Homology of Internal Genes with Human H10N8 Virus

    PubMed Central

    Ye, Ge; Liang, Chai Hong; Hua, Deng Guo; Song, Lei Yong; Xiang, Yang Guo; Guang, Chen; Lan, Chen Hua; Ping, Hua Yu

    2016-01-01

    Two human-infecting avian influenza viruses (AIVs), H7N9 and H10N8, have emerged in China, which further indicate that the H9N2 subtype of AIVs, as an internal gene donor, may have an important role in the generation of new viruses with cross-species transmissibility and pathogenicity. H9N2 viruses that contain such internal genes widely exist in poultry but are rarely reported in migratory birds. In this study, two strains of the H9N2 virus were isolated from fecal samples of migratory birds in 2014: one strain from Caizi Lake in Anhui Province and one from Chen Lake in Hubei Province of China. Nucleotide sequence analysis revealed high homology of all six internal genes of these two strains with the internal genes of the human H10N8 virus in Jiangxi Province, as well as with the human H7N9 virus. Phylogenetic analysis indicated a possible origin of these two strains from poultry in South China. Both of the two viruses tested could replicated in respiratory organs of infective mice without adaption, by both strains of the H9N2 AIVs from wild birds, suggesting their potential capacity for directly infecting mammals. Our findings indicate the existence of H9N2 viruses that contain internal genes highly homologous with human H10N8 or H7N9 viruses. Wild birds can contribute to the spread of the H9N2 virus that contains the “harmful” internal gene complex, leading to gene rearrangement with other influenza viruses and to the generation of new pathogenic viruses. Therefore, strengthening AIV surveillance in wild birds can promote an understanding of the presence and prevalence of viruses and provide scientific evidence for the prevention and control of AIVs and human-infecting AIVs. PMID:26973600

  2. Phylogenetic Analysis and Pathogenicity Assessment of Two Strains of Avian Influenza Virus Subtype H9N2 Isolated from Migratory Birds: High Homology of Internal Genes with Human H10N8 Virus.

    PubMed

    Ye, Ge; Liang, Chai Hong; Hua, Deng Guo; Song, Lei Yong; Xiang, Yang Guo; Guang, Chen; Lan, Chen Hua; Ping, Hua Yu

    2016-01-01

    Two human-infecting avian influenza viruses (AIVs), H7N9 and H10N8, have emerged in China, which further indicate that the H9N2 subtype of AIVs, as an internal gene donor, may have an important role in the generation of new viruses with cross-species transmissibility and pathogenicity. H9N2 viruses that contain such internal genes widely exist in poultry but are rarely reported in migratory birds. In this study, two strains of the H9N2 virus were isolated from fecal samples of migratory birds in 2014: one strain from Caizi Lake in Anhui Province and one from Chen Lake in Hubei Province of China. Nucleotide sequence analysis revealed high homology of all six internal genes of these two strains with the internal genes of the human H10N8 virus in Jiangxi Province, as well as with the human H7N9 virus. Phylogenetic analysis indicated a possible origin of these two strains from poultry in South China. Both of the two viruses tested could replicated in respiratory organs of infective mice without adaption, by both strains of the H9N2 AIVs from wild birds, suggesting their potential capacity for directly infecting mammals. Our findings indicate the existence of H9N2 viruses that contain internal genes highly homologous with human H10N8 or H7N9 viruses. Wild birds can contribute to the spread of the H9N2 virus that contains the "harmful" internal gene complex, leading to gene rearrangement with other influenza viruses and to the generation of new pathogenic viruses. Therefore, strengthening AIV surveillance in wild birds can promote an understanding of the presence and prevalence of viruses and provide scientific evidence for the prevention and control of AIVs and human-infecting AIVs.

  3. 33 CFR 6.10-9 - Appeals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Appeals. 6.10-9 Section 6.10-9... and Waterfront Facilities § 6.10-9 Appeals. Persons who are refused employment or who are refused the... right of appeal, and the Commandant shall appoint Boards for acting on such appeals. Each such...

  4. 33 CFR 6.10-9 - Appeals.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Appeals. 6.10-9 Section 6.10-9... and Waterfront Facilities § 6.10-9 Appeals. Persons who are refused employment or who are refused the... right of appeal, and the Commandant shall appoint Boards for acting on such appeals. Each such...

  5. 33 CFR 6.10-9 - Appeals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Appeals. 6.10-9 Section 6.10-9... and Waterfront Facilities § 6.10-9 Appeals. Persons who are refused employment or who are refused the... right of appeal, and the Commandant shall appoint Boards for acting on such appeals. Each such...

  6. 32 CFR 9.10 - Other.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Other. 9.10 Section 9.10 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS PROCEDURES FOR TRIALS BY MILITARY COMMISSIONS OF CERTAIN NON-UNITED STATES CITIZENS IN THE WAR AGAINST TERRORISM § 9.10 Other....

  7. Uses of monoclonial antibody 8H9

    DOEpatents

    Cheung, Nai-Kong V.

    2015-06-23

    This invention provides an antibody that binds the same antigen as that of monoclonal antibody 8H9, wherein the heavy chain CDR (Complementary Determining Region)1 comprises NYDIN, heavy chain CDR2 comprises WIFPGDGSTQY, heavy chain CDR3 comprises QTTATWFAY, and the light chain CDR1 comprises RASQSISDYLH, light chain CDR2 comprises YASQSIS, and light chain CDR3 comprises QNGHSFPLT. In another embodiment, there is provided a polypeptide that binds the same antigen as that of monoclonal antibody 8H9, wherein the polypeptide comprises NYDIN, WIFPGDGSTQY, QTTATWFAY, RASQSISDYLH, YASQSIS, and QNGHSFPLT.

  8. 8. August, 1970 PUMP BEHIND PELEG COGGESHALL HOUSE, 10 ORANGE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. August, 1970 PUMP BEHIND PELEG COGGESHALL HOUSE, 10 ORANGE STREET (MASS-1063) - Orange & Union Streets Neighborhood Study, 8-31 Orange Street, 9-21 Union Street & Stone Alley, Nantucket, Nantucket County, MA

  9. 10 CFR 9.105 - Commission procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Commission procedures. 9.105 Section 9.105 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS Government in the Sunshine Act Regulations § 9.105 Commission procedures. (a) Action under § 9.104 shall be taken only when a majority of the entire membership of...

  10. 32 CFR 10.8 - Amendment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Amendment. 10.8 Section 10.8 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS MILITARY COMMISSION INSTRUCTIONS § 10.8 Amendment. The General Counsel may issue, supplement, amend, or revoke any...

  11. 38 CFR 8.10 - How paid.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false How paid. 8.10 Section 8.10 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS NATIONAL SERVICE LIFE INSURANCE Dividends § 8.10 How paid. (a) Except as hereinafter provided in this paragraph, a National Service Life Insurance policy shall participate...

  12. Synthesis and structural study of 4-(2-chlorophenyl)-2-ethoxy-5,6,7,8,9,10-hexahydrocycloocta[B]pyridine-3-carbonitrile

    NASA Astrophysics Data System (ADS)

    Fathima, K. Saiadali; Vasumathi, M.; Anitha, K.

    2016-05-01

    The novel organic material C20H21ClN2O was synthesized by One-Pot synthesis method and the single crystals were grown by slow evaporation solution growth technique. The crystal structure was elucidated by subjecting the grown crystals to the single crystal x-ray diffraction analysis and was refined by full matrix least-squares method to R=0.039 for 2746 reflections. Crystal system of the grown crystal was found to be monoclinic with the space group P21/a and a=9.196(4) Å, b=13.449(4) Å, c=14.818(4) Å, β= 101.542(3)°, V=1795.6(11) Å3 and Z=4. In this crystal structure, cyclooctanone prefers to reside in a chair-boat conformation. The structure is stabilized by attractive molecular force such as CH/π interaction called hydrophobic interaction.

  13. 8,9-DIHYDROXY-8,9-DIHYDRODIBENZO[A,L]PYRENE IS A POTENT MORPHOLOGICAL CELL-TRANSFORMING AGENT IN C3H10T1/2C18 MOUSE EMBRYO FIBROBLASTS IN THE ABSENCE OF DETECTABLE STABLE COVALENT DNA ADDUCTS

    EPA Science Inventory

    The comparative genotoxic effects of racemic trans-8,9dihydroxy-8,9-dihydrodibenzo[a,l]pyrene (trans- DB[a,l]P8,9-diol), the metabolic K-region dihydrodiol of dibenzo[a,l] pyrene (DB[a,l]P) (dibenzo[def,p]chrysene) and DB[a,l]P in transformable mouse embryo C3HIOT1/2C18 (C3HIOT1/...

  14. Ligand-field theory applied to diatomic transition metals. Results for the dA9dB9σ2 states of Ni2, the dNi9dCu10σ2 states of NiCu, and the dNi8(3F)dCu10σ2σ*1 excited states of NiCu

    NASA Astrophysics Data System (ADS)

    Spain, Eileen M.; Morse, Michael D.

    1992-10-01

    A ligand-field theory has been developed for transition-metal diatomics having electronic configurations of dA9dB10σ2, dA9dB9σ2, and dA8(3F)dB10σ2σ*1. The theory treats each atom as a point charge and includes spin-orbit interactions. No contributions due to d-orbital chemical bonding are included. Since the d orbitals are quite small compared to the bond lengths in these molecules, the only inputs to the theory are the ligand charges (ZA and ZB), the radial expectation values 1.0, and using radial expectation values and spin-orbit parameters from atomic tables) provide essentially quantitative agreement with ab initio results on the dNi9dCu10σ2 manifold of states in NiCu, and on the dA9dB9σ2 manifold of states in Ni2. This demonstrates that the ligand-field model has some validity for metal molecules containing nickel, primarily because of the compact nature of the 3d orbitals in this element. Similar calculations of the dA9dB9σ2 manifold of states in Pt2 and the dNi9dPt9σ2 manifold of states in NiPt are presented for comparison to future ab initio or experimental measurements, although the possibility of d-orbital contributions to the bonding in these species makes the ligand-field model less favorable in these examples. The dNi8(3F)dCu10σ2σ*1 excited electronic states of NiCu, which are well known from resonant two-photon ionization spectroscopy, are also investigated in the ligand-field model. As a final example, the dNi8(3F)σ2σ*1 excited electronic states of NiH are also examined using the same treatment as that employed for the dNi8(3F)dCu10σ2σ*1 excited manifold of NiCu.

  15. The 9Be(8Li,9Be)8Li elastic-transfer reaction

    NASA Astrophysics Data System (ADS)

    Camargo, O.; Guimarães, V.; Lichtenthäler, R.; Scarduelli, V.; Kolata, J. J.; Bertulani, C. A.; Amro, H.; Becchetti, F. D.; Jiang, Hao; Aguilera, E. F.; Lizcano, D.; Martinez-Quiroz, E.; Garcia, H.

    2008-09-01

    Angular distributions for the 9Be(8Li,9Be)8Li elastic-transfer reaction have been measured with a 27-MeV Li8 radioactive nuclear beam. Spectroscopic factors for the <9Be|8Li+p> bound system were obtained from the comparison between the experimental differential cross sections and finite-range distorted-wave Born approximation calculations made with the code FRESCO. The spectroscopic factors so obtained are compared with shell-model calculations and other experimental values. Using the present value for the spectroscopic factors, cross sections and reaction rates for the 8Li(p,γ)9Be direct proton-capture reaction of astrophysical interest were calculated in the framework of the potential model.

  16. 10 CFR 71.9 - Employee protection.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Employee protection. 71.9 Section 71.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PACKAGING AND TRANSPORTATION OF RADIOACTIVE MATERIAL General Provisions § 71.9 Employee protection. (a) Discrimination by a Commission licensee, certificate holder,...

  17. 10 CFR 71.9 - Employee protection.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Employee protection. 71.9 Section 71.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PACKAGING AND TRANSPORTATION OF RADIOACTIVE MATERIAL General Provisions § 71.9 Employee protection. (a) Discrimination by a Commission licensee, certificate holder,...

  18. 10 CFR 71.9 - Employee protection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Employee protection. 71.9 Section 71.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PACKAGING AND TRANSPORTATION OF RADIOACTIVE MATERIAL General Provisions § 71.9 Employee protection. (a) Discrimination by a Commission licensee, certificate holder,...

  19. 10 CFR 71.9 - Employee protection.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Employee protection. 71.9 Section 71.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PACKAGING AND TRANSPORTATION OF RADIOACTIVE MATERIAL General Provisions § 71.9 Employee protection. (a) Discrimination by a Commission licensee, certificate holder,...

  20. 10 CFR 71.9 - Employee protection.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Employee protection. 71.9 Section 71.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PACKAGING AND TRANSPORTATION OF RADIOACTIVE MATERIAL General Provisions § 71.9 Employee protection. (a) Discrimination by a Commission licensee, certificate holder,...

  1. 10 CFR 216.9 - Violations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Violations. 216.9 Section 216.9 Energy DEPARTMENT OF ENERGY OIL MATERIALS ALLOCATION AND PRIORITY PERFORMANCE UNDER CONTRACTS OR ORDERS TO MAXIMIZE DOMESTIC ENERGY SUPPLIES § 216.9 Violations. Any person who willfully furnishes false information or conceals...

  2. 10 CFR 9.5 - Interpretations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Interpretations. 9.5 Section 9.5 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS § 9.5 Interpretations. Except as specifically authorized by the Commission in writing, no interpretation of the meaning of the regulations in this part by an officer or employee of...

  3. 10 CFR 9.5 - Interpretations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Interpretations. 9.5 Section 9.5 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS § 9.5 Interpretations. Except as specifically authorized by the Commission in writing, no interpretation of the meaning of the regulations in this part by an officer or employee of...

  4. 10 CFR 9.5 - Interpretations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Interpretations. 9.5 Section 9.5 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS § 9.5 Interpretations. Except as specifically authorized by the Commission in writing, no interpretation of the meaning of the regulations in this part by an officer or employee of...

  5. 10 CFR 9.51 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Definitions. 9.51 Section 9.51 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS Privacy Act Regulations § 9.51 Definitions. As used in this subpart: (a) Individual means a citizen of the United States or an alien lawfully admitted for permanent residence. (b) The...

  6. 10 CFR 9.5 - Interpretations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Interpretations. 9.5 Section 9.5 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS § 9.5 Interpretations. Except as specifically authorized by the Commission in writing, no interpretation of the meaning of the regulations in this part by an officer or employee of...

  7. 10 CFR 9.5 - Interpretations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Interpretations. 9.5 Section 9.5 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS § 9.5 Interpretations. Except as specifically authorized by the Commission in writing, no interpretation of the meaning of the regulations in this part by an officer or employee of...

  8. 10 CFR 13.9 - Answer.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Answer. 13.9 Section 13.9 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.9 Answer. (a) The defendant may request a hearing by filing an answer with the reviewing official within thirty (30) days of service of the complaint. Service of...

  9. 10 CFR 171.9 - Communications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Communications. 171.9 Section 171.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ANNUAL FEES FOR REACTOR LICENSES AND FUEL CYCLE LICENSES AND MATERIALS... APPROVALS AND GOVERNMENT AGENCIES LICENSED BY THE NRC § 171.9 Communications. All communications...

  10. 10 CFR 95.9 - Communications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Communications. 95.9 Section 95.9 Energy NUCLEAR... INFORMATION AND RESTRICTED DATA General Provisions § 95.9 Communications. Except where otherwise specified, all communications and reports concerning the regulations in this part should be submitted as...

  11. 10 CFR 25.9 - Communications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Communications. 25.9 Section 25.9 Energy NUCLEAR REGULATORY COMMISSION ACCESS AUTHORIZATION General Provisions § 25.9 Communications. Except where otherwise specified, communications and reports concerning the regulations in this part should be addressed to...

  12. 10 CFR 171.9 - Communications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Communications. 171.9 Section 171.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ANNUAL FEES FOR REACTOR LICENSES AND FUEL CYCLE LICENSES AND MATERIALS... APPROVALS AND GOVERNMENT AGENCIES LICENSED BY THE NRC § 171.9 Communications. All communications...

  13. 10 CFR 95.9 - Communications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Communications. 95.9 Section 95.9 Energy NUCLEAR... INFORMATION AND RESTRICTED DATA General Provisions § 95.9 Communications. Except where otherwise specified, all communications and reports concerning the regulations in this part should be submitted as...

  14. 10 CFR 25.9 - Communications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Communications. 25.9 Section 25.9 Energy NUCLEAR REGULATORY COMMISSION ACCESS AUTHORIZATION General Provisions § 25.9 Communications. Except where otherwise specified, communications and reports concerning the regulations in this part should be addressed to...

  15. 10 CFR 171.9 - Communications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Communications. 171.9 Section 171.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ANNUAL FEES FOR REACTOR LICENSES AND FUEL CYCLE LICENSES AND MATERIALS... APPROVALS AND GOVERNMENT AGENCIES LICENSED BY THE NRC § 171.9 Communications. All communications...

  16. 10 CFR 95.9 - Communications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Communications. 95.9 Section 95.9 Energy NUCLEAR... INFORMATION AND RESTRICTED DATA General Provisions § 95.9 Communications. Except where otherwise specified, all communications and reports concerning the regulations in this part should be submitted as...

  17. 10 CFR 25.9 - Communications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Communications. 25.9 Section 25.9 Energy NUCLEAR REGULATORY COMMISSION ACCESS AUTHORIZATION General Provisions § 25.9 Communications. Except where otherwise specified, communications and reports concerning the regulations in this part should be addressed to...

  18. 10 CFR 171.9 - Communications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Communications. 171.9 Section 171.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ANNUAL FEES FOR REACTOR LICENSES AND FUEL CYCLE LICENSES AND MATERIALS... APPROVALS AND GOVERNMENT AGENCIES LICENSED BY THE NRC § 171.9 Communications. All communications...

  19. 10 CFR 95.9 - Communications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Communications. 95.9 Section 95.9 Energy NUCLEAR... INFORMATION AND RESTRICTED DATA General Provisions § 95.9 Communications. Except where otherwise specified, all communications and reports concerning the regulations in this part should be submitted as...

  20. 10 CFR 171.9 - Communications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Communications. 171.9 Section 171.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ANNUAL FEES FOR REACTOR LICENSES AND FUEL CYCLE LICENSES AND MATERIALS... APPROVALS AND GOVERNMENT AGENCIES LICENSED BY THE NRC § 171.9 Communications. All communications...

  1. 10 CFR 95.9 - Communications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Communications. 95.9 Section 95.9 Energy NUCLEAR... INFORMATION AND RESTRICTED DATA General Provisions § 95.9 Communications. Except where otherwise specified, all communications and reports concerning the regulations in this part should be submitted as...

  2. 10 CFR 25.9 - Communications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Communications. 25.9 Section 25.9 Energy NUCLEAR REGULATORY COMMISSION ACCESS AUTHORIZATION General Provisions § 25.9 Communications. Except where otherwise specified, communications and reports concerning the regulations in this part should be addressed to...

  3. 10 CFR 9.101 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Definitions. 9.101 Section 9.101 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS Government in the Sunshine Act Regulations § 9.101 Definitions. As used in this subpart: (a) Commission means the collegial body of five Commissioners or a quorum thereof as provided by section 201 of the...

  4. 10 CFR 63.9 - Employee protection.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Employee protection. 63.9 Section 63.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA General Provisions § 63.9 Employee protection. (a) Discrimination by a Commission...

  5. 10 CFR 63.9 - Employee protection.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Employee protection. 63.9 Section 63.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA General Provisions § 63.9 Employee protection. (a) Discrimination by a Commission...

  6. 10 CFR 63.9 - Employee protection.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Employee protection. 63.9 Section 63.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA General Provisions § 63.9 Employee protection. (a) Discrimination by a Commission...

  7. 10 CFR 63.9 - Employee protection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Employee protection. 63.9 Section 63.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA General Provisions § 63.9 Employee protection. (a) Discrimination by a Commission...

  8. 10 CFR 63.9 - Employee protection.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Employee protection. 63.9 Section 63.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA General Provisions § 63.9 Employee protection. (a) Discrimination by a Commission...

  9. 10 CFR 216.9 - Violations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Violations. 216.9 Section 216.9 Energy DEPARTMENT OF ENERGY OIL MATERIALS ALLOCATION AND PRIORITY PERFORMANCE UNDER CONTRACTS OR ORDERS TO MAXIMIZE DOMESTIC ENERGY SUPPLIES § 216.9 Violations. Any person who willfully furnishes false information or conceals...

  10. 10 CFR 216.9 - Violations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Violations. 216.9 Section 216.9 Energy DEPARTMENT OF ENERGY OIL MATERIALS ALLOCATION AND PRIORITY PERFORMANCE UNDER CONTRACTS OR ORDERS TO MAXIMIZE DOMESTIC ENERGY SUPPLIES § 216.9 Violations. Any person who willfully furnishes false information or conceals...

  11. 10 CFR 216.9 - Violations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Violations. 216.9 Section 216.9 Energy DEPARTMENT OF ENERGY OIL MATERIALS ALLOCATION AND PRIORITY PERFORMANCE UNDER CONTRACTS OR ORDERS TO MAXIMIZE DOMESTIC ENERGY SUPPLIES § 216.9 Violations. Any person who willfully furnishes false information or conceals...

  12. 10 CFR 216.9 - Violations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Violations. 216.9 Section 216.9 Energy DEPARTMENT OF ENERGY OIL MATERIALS ALLOCATION AND PRIORITY PERFORMANCE UNDER CONTRACTS OR ORDERS TO MAXIMIZE DOMESTIC ENERGY SUPPLIES § 216.9 Violations. Any person who willfully furnishes false information or conceals...

  13. 10 CFR 26.9 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Specific exemptions. 26.9 Section 26.9 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.9 Specific exemptions. Upon application of any interested person or on its own initiative, the Commission may grant such exemptions...

  14. 10 CFR 25.9 - Communications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Communications. 25.9 Section 25.9 Energy NUCLEAR REGULATORY COMMISSION ACCESS AUTHORIZATION General Provisions § 25.9 Communications. Except where otherwise specified, communications and reports concerning the regulations in this part should be addressed to...

  15. 10 CFR 37.9 - Interpretations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Interpretations. 37.9 Section 37.9 Energy NUCLEAR REGULATORY COMMISSION PHYSICAL PROTECTION OF CATEGORY 1 AND CATEGORY 2 QUANTITIES OF RADIOACTIVE MATERIAL General Provisions § 37.9 Interpretations. Except as specifically authorized by the Commission in...

  16. 10 CFR 52.9 - Jurisdictional limits.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Jurisdictional limits. 52.9 Section 52.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General Provisions § 52.9 Jurisdictional limits. No permit, license, standard design approval, or standard...

  17. 10 CFR 52.9 - Jurisdictional limits.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Jurisdictional limits. 52.9 Section 52.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General Provisions § 52.9 Jurisdictional limits. No permit, license, standard design approval, or standard...

  18. 10 CFR 52.9 - Jurisdictional limits.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Jurisdictional limits. 52.9 Section 52.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General Provisions § 52.9 Jurisdictional limits. No permit, license, standard design approval, or standard...

  19. 10 CFR 52.9 - Jurisdictional limits.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Jurisdictional limits. 52.9 Section 52.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General Provisions § 52.9 Jurisdictional limits. No permit, license, standard design approval, or standard...

  20. 10 CFR 52.9 - Jurisdictional limits.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Jurisdictional limits. 52.9 Section 52.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General Provisions § 52.9 Jurisdictional limits. No permit, license, standard design approval, or standard...

  1. 10 CFR 26.9 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Specific exemptions. 26.9 Section 26.9 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.9 Specific exemptions. Upon application of any interested person or on its own initiative, the Commission may grant such exemptions...

  2. 10 CFR 26.9 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Specific exemptions. 26.9 Section 26.9 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.9 Specific exemptions. Upon application of any interested person or on its own initiative, the Commission may grant such exemptions...

  3. 10 CFR 26.9 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Specific exemptions. 26.9 Section 26.9 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.9 Specific exemptions. Upon application of any interested person or on its own initiative, the Commission may grant such exemptions...

  4. 10 CFR 26.9 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Specific exemptions. 26.9 Section 26.9 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.9 Specific exemptions. Upon application of any interested person or on its own initiative, the Commission may grant such exemptions...

  5. 10 CFR 9.101 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Definitions. 9.101 Section 9.101 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS Government in the Sunshine Act Regulations § 9.101 Definitions. As used in this....104. (e) Open meeting means a meeting of the Commission open to public observation pursuant to...

  6. 10 CFR 9.102 - General requirement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false General requirement. 9.102 Section 9.102 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS Government in the Sunshine Act Regulations § 9.102 General requirement... shall be open to public observation....

  7. 38 CFR 9.10 - Health standards.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false Health standards. 9.10... LIFE INSURANCE AND VETERANS' GROUP LIFE INSURANCE § 9.10 Health standards. (a) For the purpose of... criteria used by the insurer in determining good health for persons applying to it for life insurance...

  8. 38 CFR 9.10 - Health standards.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Health standards. 9.10... LIFE INSURANCE AND VETERANS' GROUP LIFE INSURANCE § 9.10 Health standards. (a) For the purpose of... criteria used by the insurer in determining good health for persons applying to it for life insurance...

  9. 38 CFR 9.10 - Health standards.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false Health standards. 9.10... LIFE INSURANCE AND VETERANS' GROUP LIFE INSURANCE § 9.10 Health standards. (a) For the purpose of... criteria used by the insurer in determining good health for persons applying to it for life insurance...

  10. 38 CFR 9.10 - Health standards.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Health standards. 9.10... LIFE INSURANCE AND VETERANS' GROUP LIFE INSURANCE § 9.10 Health standards. (a) For the purpose of... criteria used by the insurer in determining good health for persons applying to it for life insurance...

  11. 38 CFR 9.10 - Health standards.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2012-07-01 2012-07-01 false Health standards. 9.10... LIFE INSURANCE AND VETERANS' GROUP LIFE INSURANCE § 9.10 Health standards. (a) For the purpose of... criteria used by the insurer in determining good health for persons applying to it for life insurance...

  12. 10 CFR 61.9 - Employee protection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Employee protection. 61.9 Section 61.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE General... in 10 CFR 19.11(c). This form must be posted at locations sufficient to permit employees protected...

  13. 10 CFR 61.9 - Employee protection.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Employee protection. 61.9 Section 61.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE General... in 10 CFR 19.11(c). This form must be posted at locations sufficient to permit employees protected...

  14. 10 CFR 60.9 - Employee protection.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Employee protection. 60.9 Section 60.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES General... in 10 CFR 19.11(c). This form must be posted at locations sufficient to permit employees protected...

  15. 10 CFR 60.9 - Employee protection.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Employee protection. 60.9 Section 60.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES General... in 10 CFR 19.11(c). This form must be posted at locations sufficient to permit employees protected...

  16. 10 CFR 61.9 - Employee protection.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Employee protection. 61.9 Section 61.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE General... in 10 CFR 19.11(c). This form must be posted at locations sufficient to permit employees protected...

  17. 10 CFR 61.9 - Employee protection.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Employee protection. 61.9 Section 61.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE General... in 10 CFR 19.11(c). This form must be posted at locations sufficient to permit employees protected...

  18. 10 CFR 60.9 - Employee protection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Employee protection. 60.9 Section 60.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES General... in 10 CFR 19.11(c). This form must be posted at locations sufficient to permit employees protected...

  19. 10 CFR 60.9 - Employee protection.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Employee protection. 60.9 Section 60.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES General... in 10 CFR 19.11(c). This form must be posted at locations sufficient to permit employees protected...

  20. 10 CFR 60.9 - Employee protection.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Employee protection. 60.9 Section 60.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES General... in 10 CFR 19.11(c). This form must be posted at locations sufficient to permit employees protected...

  1. 10 CFR 61.9 - Employee protection.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Employee protection. 61.9 Section 61.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE General... in 10 CFR 19.11(c). This form must be posted at locations sufficient to permit employees protected...

  2. 8 CFR 1240.10 - Hearing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Hearing. 1240.10 Section 1240.10 Aliens and... TO DETERMINE REMOVABILITY OF ALIENS IN THE UNITED STATES Removal Proceedings § 1240.10 Hearing. (a... organizations and attorneys qualified under 8 CFR part 1003 and organizations recognized pursuant to § 1292.2...

  3. 8 CFR 1240.10 - Hearing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Hearing. 1240.10 Section 1240.10 Aliens and... TO DETERMINE REMOVABILITY OF ALIENS IN THE UNITED STATES Removal Proceedings § 1240.10 Hearing. (a... organizations and attorneys qualified under 8 CFR part 1003 and organizations recognized pursuant to § 1292.2...

  4. 8 CFR 1240.10 - Hearing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Hearing. 1240.10 Section 1240.10 Aliens and... TO DETERMINE REMOVABILITY OF ALIENS IN THE UNITED STATES Removal Proceedings § 1240.10 Hearing. (a... organizations and attorneys qualified under 8 CFR part 1003 and organizations recognized pursuant to § 1292.2...

  5. 8 CFR 1240.10 - Hearing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Hearing. 1240.10 Section 1240.10 Aliens and... TO DETERMINE REMOVABILITY OF ALIENS IN THE UNITED STATES Removal Proceedings § 1240.10 Hearing. (a... organizations and attorneys qualified under 8 CFR part 1003 and organizations recognized pursuant to § 1292.2...

  6. 8 CFR 1240.10 - Hearing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Hearing. 1240.10 Section 1240.10 Aliens and... TO DETERMINE REMOVABILITY OF ALIENS IN THE UNITED STATES Removal Proceedings § 1240.10 Hearing. (a... organizations and attorneys qualified under 8 CFR part 1003 and organizations recognized pursuant to § 1292.2...

  7. Synthesis, structure activity relationship and mode of action of 3-substitutedphenyl-1-(2,2,8,8-tetramethyl-3,4,9,10-tetrahydro-2H,8H-pyrano[2,3-f]chromen-6-yl)-propenones as novel anticancer agents in human leukaemia HL-60 cells.

    PubMed

    Murthy, Y L N; Suhasini, K P; Pathania, A S; Bhushan, S; Nagendra Sastry, Y

    2013-04-01

    A novel class of 3-substitutedphenyl-1-(2,2,8,8-tetramethyl-3,4,9,10-tetrahydro-2H,8H-pyrano[2,3-f]chromen-6-yl)-propenones were designed, synthesized and evaluated for their antiproliferative activity against the human cancer cell lines of diverse origin. Structure activity relationship was elucidated with various substitutions on the benzene ring and these variations significantly affected the potency. Most of the twelve tested compounds inhibited the growth of aggressive cancer cell lines. Moreover, three compounds 4j, 4k and 4l displayed excellent cytotoxic profile by inhibiting >90% cell proliferation in HL-60 and Caco-2 cells at 50 μM concentration. Further studies to elucidate the mode of action revealed that these three compounds induced G0/G1 cell cycle arrest and apoptosis, which was accompanied by loss of mitochondrial membrane potential, DNA fragmentation and nuclear morphology in HL-60 cells.

  8. 6. Historic view, Pier 9, 10, 11. Aerial Views to ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Historic view, Pier 9, 10, 11. Aerial Views to east, 1943. Photographic copy of photo. Boston National Historical Park Archives, Charlestown Navy Yard. - Charlestown Navy Yard, Pier 9, Between Piers 8 & 10, along Mystic River on Charlestown Waterfront at eastern edge of Navy Yard, Boston, Suffolk County, MA

  9. In vitro metabolism of 10-(3-chlorophenyl)-6,8,9,10-tetrahydrobenzo[b][1,8]naphthyridin-5(7H)- one, a topical antipsoriatic agent. Use of precision-cut rat, dog, monkey and human liver slices, and chemical synthesis of metabolites.

    PubMed

    Zbaida, S; Du, Y; Shannon, D; Laudicina, D; Thonoor, C M; Ng, K; Blumenkrantz, N; Patrick, J E; Cayen, M N; Friary, R; Seidl, V; Chan, T M; Pramanik, B; Spangler, M; McPhail, A T

    1998-07-01

    The metabolism of SCH 40120, which is the clinically effective antipsoriatic drug 10-(3-chlorophenyl)-6,8,9,10-tetrahydrobenzol[b][1,8]naphthyrid in-5(7H)-one, was determined in vitro. Rat, dog, cynomolgus monkey, and human liver slices hydroxylated the aliphatic, cyclohexenyl ring of the drug and conjugated the resulting carbinol. The identified metabolites comprised the corresponding 6-, 7-, and 9-carbinols, the glucuronide of the 6-carbinol, and the 6-ketone derived from the parent drug. Although the three carbinols appeared in the liver isolates of all species studied, the relative amounts of these metabolites varied across species. With a high, non-physiological ratio of substrate to liver, the 6-carbinol and its glucuronide were the major metabolites in human and monkey, whereas the 6-ketone was a minor metabolite in dog. Containing a stereogenic axis and center, the 6-carbinol existed as diastereomeric atropisomers. Its structure was established by 13C and 1H NMR spectroscopy, mass spectrometry, and comparison to an authentic sample. PMID:9673784

  10. 9 CFR 146.10 - Supervision.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Supervision. 146.10 Section 146.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR COMMERCIAL POULTRY General Provisions § 146.10 Supervision. (a) The Official State Agency...

  11. 9 CFR 166.10 - Licensing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Licensing. 166.10 Section 166.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE SWINE HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.10 Licensing. (a) Application....

  12. High Expression of Rabl3 is Associated with Poor Survival of Patients with Non-Small Cell Lung Cancer via Repression of MAPK8/9/10-Mediated Autophagy

    PubMed Central

    Zhang, Weihua; Sun, Jian; Luo, Junming

    2016-01-01

    Background Rab-like 3 (Rabl3) is a member of the Rab subfamily of small GTPases which are involved in controlling proliferation and vesicular trafficking. Recent studies suggest that Rab proteins might play a critical role in regulating cancer cell survival, but the underlying mechanisms remain largely unknown. Material/Methods We performed a bioinformatics analysis to examine the correlation between the expression level of Rabl3 and survival of non-small cell lung cancer (NSCLC) patients in three independent cohorts containing 484 patients. The function of Rabl3 was examined in NSCLC cell line A549 in vitro. Following Rabl3 knockdown, cells were stained with propidium iodine (PI) and Annexin V, followed by flow cytometry analysis (FACS) for cell death and autophagy induction. The activity of the MAPK signaling pathway was assessed by Western blotting of different MAPK phosphorylations, and modulated with different chemical inhibitors. Results High expression of Rabl3 was significantly correlated with poor survival in all three independent NSCLC cohorts. In line with this result, Rabl3 was frequently overexpressed in lung cancer cell lines as compared with normal lung fibroblast cell lines. Knockdown of Rabl3 in lung cancer cells significantly enhanced cell death accompanied with autophagy induction, as evidenced by an increased level of autophagy marker LC3-II. Interestingly, Rabl3 knockdown was associated with enhanced activation of MAPK8/9/10 but not MAPK11/12/13/14. Treatment of MAPK8/9/10-specific inhibitor SP600125, but not MAPK11/12/13/14-specific inhibitor SB203580, largely abolished Rabl3 knockdown-induced LC3-I/LC3-II conversion and autophagic cell death. Conclusions Together, these results suggest that high expression of Rabl3 might inhibit cell death in NSCLCs via repression of MAPK8/9/10-mediated autophagy. PMID:27164297

  13. Transmission of electronic effects through the {closo-1-CB9} and {closo-1-CB11} cages: apparent dissociation constants for series of [closo-1-CB9H8-1-COOH-10-X] and [closo-1-CB11H10-1-COOH-12-X] acids.

    PubMed

    Pecyna, Jacek G; Ringstrand, Bryan; Kaszyński, Piotr

    2012-05-01

    The apparent ionization constants pK(a)' for series of carboxylic acids [closo-1-CB(9)H(8)-1-COOH-10-X](-) (1) and [closo-1-CB(11)H(10)-1-COOH-12-X](-) (2), where X = H, I, n-C(6)H(13), (+)NMe(3), (+)N(2), (+)SMe(2), OC(5)H(11), were measured in EtOH/H(2)O (1/1, v/v) at 24 °C. Correlation analysis of the pK(a)' values using Hammett substituent constants σ(p)(X) gave the reaction constant ρ = 0.87 ± 0.04 for series 1 and ρ = 1.00 ± 0.09 for series 2. These values are higher than for derivatives of PhCH═CHCOOH (ρ = 0.70 ± 0.09 in 55% EtOH) and correspond to 56% and 65% efficiencies in transmission of electronic effects by [closo-1-CB(9)H(10)](-) (E) and [closo-1-CB(11)H(12)](-) (F), respectively, as compared to benzene (A). Experimental results were supported with DFT calculations of relative acidity for series of acids derived from A, E, and F in aqueous medium.

  14. 9 CFR 441.10 - Retained water.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... standard for Salmonella as set forth in the PR/HACCP regulations (9 CFR 310.25(b), 381.94(b)) and the time/temperature requirements set forth in 9 CFR 381.66. Additional purposes that could be included are determining... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Retained water. 441.10 Section...

  15. 9 CFR 441.10 - Retained water.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... standard for Salmonella as set forth in the PR/HACCP regulations (9 CFR 310.25(b), 381.94(b)) and the time/temperature requirements set forth in 9 CFR 381.66. Additional purposes that could be included are determining... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Retained water. 441.10 Section...

  16. 9 CFR 441.10 - Retained water.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... standard for Salmonella as set forth in the PR/HACCP regulations (9 CFR 310.25(b), 381.94(b)) and the time/temperature requirements set forth in 9 CFR 381.66. Additional purposes that could be included are determining... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Retained water. 441.10 Section...

  17. 9 CFR 441.10 - Retained water.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... standard for Salmonella as set forth in the PR/HACCP regulations (9 CFR 310.25(b), 381.94(b)) and the time/temperature requirements set forth in 9 CFR 381.66. Additional purposes that could be included are determining... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Retained water. 441.10 Section...

  18. 9 CFR 441.10 - Retained water.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... standard for Salmonella as set forth in the PR/HACCP regulations (9 CFR 310.25(b), 381.94(b)) and the time/temperature requirements set forth in 9 CFR 381.66. Additional purposes that could be included are determining... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Retained water. 441.10 Section...

  19. 10 CFR 9.90 - Violations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Violations. 9.90 Section 9.90 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS Privacy Act Regulations Enforcement § 9.90 Violations. (a) An injunction or other court order may be obtained pursuant to 5 U.S.C. 552a(g) (1-3) to compel NRC to permit an individual...

  20. 10 CFR 9.90 - Violations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Violations. 9.90 Section 9.90 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS Privacy Act Regulations Enforcement § 9.90 Violations. (a) An injunction or other court order may be obtained pursuant to 5 U.S.C. 552a(g) (1-3) to compel NRC to permit an individual...

  1. 10 CFR 9.90 - Violations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Violations. 9.90 Section 9.90 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS Privacy Act Regulations Enforcement § 9.90 Violations. (a) An injunction or other court order may be obtained pursuant to 5 U.S.C. 552a(g) (1-3) to compel NRC to permit an individual...

  2. 10 CFR 9.90 - Violations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Violations. 9.90 Section 9.90 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS Privacy Act Regulations Enforcement § 9.90 Violations. (a) An injunction or other court order may be obtained pursuant to 5 U.S.C. 552a(g) (1-3) to compel NRC to permit an individual...

  3. 10 CFR 9.90 - Violations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Violations. 9.90 Section 9.90 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS Privacy Act Regulations Enforcement § 9.90 Violations. (a) An injunction or other court order may be obtained pursuant to 5 U.S.C. 552a(g) (1-3) to compel NRC to permit an individual...

  4. 41 CFR 51-8.10 - Appeals.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 41 Public Contracts and Property Management 1 2012-07-01 2009-07-01 true Appeals. 51-8.10 Section... MATERIALS § 51-8.10 Appeals. (a) An appeal to the Chairperson of any denial, in whole or in part, of a... denial. (b) The Chairperson shall make a determination with respect to any appeal within 20...

  5. 41 CFR 51-8.10 - Appeals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 41 Public Contracts and Property Management 1 2014-07-01 2014-07-01 false Appeals. 51-8.10 Section... MATERIALS § 51-8.10 Appeals. (a) An appeal to the Chairperson of any denial, in whole or in part, of a... denial. (b) The Chairperson shall make a determination with respect to any appeal within 20...

  6. 41 CFR 51-8.10 - Appeals.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 1 2013-07-01 2013-07-01 false Appeals. 51-8.10 Section... MATERIALS § 51-8.10 Appeals. (a) An appeal to the Chairperson of any denial, in whole or in part, of a... denial. (b) The Chairperson shall make a determination with respect to any appeal within 20...

  7. 8 CFR 1003.10 - Immigration judges.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... jurisdiction as provided in 8 CFR 1003.1. (d) Governing standards. Immigration judges shall be governed by the... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Immigration judges. 1003.10 Section 1003.10 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE GENERAL...

  8. 8 CFR 1003.10 - Immigration judges.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... jurisdiction as provided in 8 CFR 1003.1. (d) Governing standards. Immigration judges shall be governed by the... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Immigration judges. 1003.10 Section 1003.10 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE GENERAL...

  9. 8 CFR 1003.10 - Immigration judges.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... jurisdiction as provided in 8 CFR 1003.1. (d) Governing standards. Immigration judges shall be governed by the... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Immigration judges. 1003.10 Section 1003.10 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE GENERAL...

  10. 8 CFR 1003.10 - Immigration judges.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... jurisdiction as provided in 8 CFR 1003.1. (d) Governing standards. Immigration judges shall be governed by the... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Immigration judges. 1003.10 Section 1003.10 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE GENERAL...

  11. 8 CFR 1003.10 - Immigration judges.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... jurisdiction as provided in 8 CFR 1003.1. (d) Governing standards. Immigration judges shall be governed by the... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Immigration judges. 1003.10 Section 1003.10 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE GENERAL...

  12. 10 CFR 11.9 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Specific exemptions. 11.9 Section 11.9 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO OR CONTROL OVER... granted only if they are authorized by law and will not constitute an undue risk to the common defense...

  13. 10 CFR 9.6 - Communications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Communications. 9.6 Section 9.6 Energy NUCLEAR REGULATORY... the NRC by mail addressed to the U.S. Nuclear Regulatory Commission, Washington, DC 20555-0001; by.... Nuclear Regulatory Commission, Washington, DC 20555-0001. The guidance discusses, among other topics,...

  14. 10 CFR 9.3 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Definitions. 9.3 Section 9.3 Energy NUCLEAR REGULATORY... the Nuclear Regulatory Commission, established by the Energy Reorganization Act of 1974. NRC personnel... members or a quorum thereof sitting as a body, as provided by section 201 of the Energy Reorganization...

  15. 10 CFR 9.6 - Communications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Communications. 9.6 Section 9.6 Energy NUCLEAR REGULATORY... the NRC by mail addressed to the U.S. Nuclear Regulatory Commission, Washington, DC 20555-0001; by.... Nuclear Regulatory Commission, Washington, DC 20555-0001. The guidance discusses, among other topics,...

  16. 10 CFR 9.6 - Communications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Communications. 9.6 Section 9.6 Energy NUCLEAR REGULATORY... the NRC by mail addressed to the U.S. Nuclear Regulatory Commission, Washington, DC 20555-0001; by.... Nuclear Regulatory Commission, Washington, DC 20555-0001.The guidance discusses, among other topics,...

  17. 10 CFR 9.3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Definitions. 9.3 Section 9.3 Energy NUCLEAR REGULATORY... the Nuclear Regulatory Commission, established by the Energy Reorganization Act of 1974. NRC personnel... members or a quorum thereof sitting as a body, as provided by section 201 of the Energy Reorganization...

  18. 10 CFR 9.3 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Definitions. 9.3 Section 9.3 Energy NUCLEAR REGULATORY... the Nuclear Regulatory Commission, established by the Energy Reorganization Act of 1974. NRC personnel... members or a quorum thereof sitting as a body, as provided by section 201 of the Energy Reorganization...

  19. 10 CFR 9.6 - Communications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Communications. 9.6 Section 9.6 Energy NUCLEAR REGULATORY... the NRC by mail addressed to the U.S. Nuclear Regulatory Commission, Washington, DC 20555-0001; by.... Nuclear Regulatory Commission, Washington, DC 20555-0001. The guidance discusses, among other topics,...

  20. 10 CFR 9.6 - Communications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Communications. 9.6 Section 9.6 Energy NUCLEAR REGULATORY... the NRC by mail addressed to the U.S. Nuclear Regulatory Commission, Washington, DC 20555-0001; by.... Nuclear Regulatory Commission, Washington, DC 20555-0001. The guidance discusses, among other topics,...

  1. 10 CFR 9.3 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Definitions. 9.3 Section 9.3 Energy NUCLEAR REGULATORY... the Nuclear Regulatory Commission, established by the Energy Reorganization Act of 1974. NRC personnel... members or a quorum thereof sitting as a body, as provided by section 201 of the Energy Reorganization...

  2. 10 CFR 9.3 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Definitions. 9.3 Section 9.3 Energy NUCLEAR REGULATORY... the Nuclear Regulatory Commission, established by the Energy Reorganization Act of 1974. NRC personnel... members or a quorum thereof sitting as a body, as provided by section 201 of the Energy Reorganization...

  3. 10 CFR 824.9 - Hearing Counsel.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Hearing Counsel. 824.9 Section 824.9 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY... consistent with the objectives of the Act and DOE security requirements....

  4. 10 CFR 824.9 - Hearing Counsel.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Hearing Counsel. 824.9 Section 824.9 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY... consistent with the objectives of the Act and DOE security requirements....

  5. 10 CFR 16.9 - Hearing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Hearing. 16.9 Section 16.9 Energy NUCLEAR REGULATORY COMMISSION SALARY OFFSET PROCEDURES FOR COLLECTING DEBTS OWED BY FEDERAL EMPLOYEES TO THE FEDERAL GOVERNMENT... hearing must conform to procedures contained in the revised FCCS, 31 CFR Chapter IX, 901.3(e). The...

  6. 10 CFR 16.9 - Hearing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Hearing. 16.9 Section 16.9 Energy NUCLEAR REGULATORY COMMISSION SALARY OFFSET PROCEDURES FOR COLLECTING DEBTS OWED BY FEDERAL EMPLOYEES TO THE FEDERAL GOVERNMENT... hearing must conform to procedures contained in the revised FCCS, 31 CFR Chapter IX, 901.3(e). The...

  7. 10 CFR 16.9 - Hearing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Hearing. 16.9 Section 16.9 Energy NUCLEAR REGULATORY COMMISSION SALARY OFFSET PROCEDURES FOR COLLECTING DEBTS OWED BY FEDERAL EMPLOYEES TO THE FEDERAL GOVERNMENT... hearing must conform to procedures contained in the revised FCCS, 31 CFR Chapter IX, 901.3(e). The...

  8. 10 CFR 16.9 - Hearing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Hearing. 16.9 Section 16.9 Energy NUCLEAR REGULATORY COMMISSION SALARY OFFSET PROCEDURES FOR COLLECTING DEBTS OWED BY FEDERAL EMPLOYEES TO THE FEDERAL GOVERNMENT... hearing must conform to procedures contained in the revised FCCS, 31 CFR Chapter IX, 901.3(e). The...

  9. 10 CFR 16.9 - Hearing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Hearing. 16.9 Section 16.9 Energy NUCLEAR REGULATORY COMMISSION SALARY OFFSET PROCEDURES FOR COLLECTING DEBTS OWED BY FEDERAL EMPLOYEES TO THE FEDERAL GOVERNMENT... hearing must conform to procedures contained in the revised FCCS, 31 CFR Chapter IX, 901.3(e). The...

  10. 10 CFR 216.8 - Communications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Communications. 216.8 Section 216.8 Energy DEPARTMENT OF ENERGY OIL MATERIALS ALLOCATION AND PRIORITY PERFORMANCE UNDER CONTRACTS OR ORDERS TO MAXIMIZE DOMESTIC ENERGY SUPPLIES § 216.8 Communications. All written communications concerning these regulations shall...

  11. 10 CFR 1045.8 - Procedural exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Procedural exemptions. 1045.8 Section 1045.8 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NUCLEAR CLASSIFICATION AND DECLASSIFICATION Program Management of the Restricted Data and Formerly Restricted Data Classification System § 1045.8 Procedural...

  12. 10 CFR 1045.8 - Procedural exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Procedural exemptions. 1045.8 Section 1045.8 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NUCLEAR CLASSIFICATION AND DECLASSIFICATION Program Management of the Restricted Data and Formerly Restricted Data Classification System § 1045.8 Procedural...

  13. 10 CFR 1045.8 - Procedural exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Procedural exemptions. 1045.8 Section 1045.8 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NUCLEAR CLASSIFICATION AND DECLASSIFICATION Program Management of the Restricted Data and Formerly Restricted Data Classification System § 1045.8 Procedural...

  14. 10 CFR 1045.8 - Procedural exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Procedural exemptions. 1045.8 Section 1045.8 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NUCLEAR CLASSIFICATION AND DECLASSIFICATION Program Management of the Restricted Data and Formerly Restricted Data Classification System § 1045.8 Procedural...

  15. 10 CFR 1045.8 - Procedural exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Procedural exemptions. 1045.8 Section 1045.8 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NUCLEAR CLASSIFICATION AND DECLASSIFICATION Program Management of the Restricted Data and Formerly Restricted Data Classification System § 1045.8 Procedural...

  16. 10 CFR 824.8 - Hearing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Hearing. 824.8 Section 824.8 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY VIOLATIONS § 824.8 Hearing. (a) Any person who receives a final notice of violation under § 824.7 may request a...

  17. 10 CFR 824.8 - Hearing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Hearing. 824.8 Section 824.8 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY VIOLATIONS § 824.8 Hearing. (a) Any person who receives a final notice of violation under § 824.7 may request a...

  18. 10 CFR 780.8 - Security.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Security. 780.8 Section 780.8 Energy DEPARTMENT OF ENERGY PATENT COMPENSATION BOARD REGULATIONS General Provisions § 780.8 Security. In any proceeding under this... the Act to assure compliance with Department security regulations and the common defense....

  19. 10 CFR 820.8 - Evidentiary matters.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Evidentiary matters. 820.8 Section 820.8 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR DOE NUCLEAR ACTIVITIES General § 820.8 Evidentiary matters. (a... matter related to a DOE nuclear activity or for any decision required by this part. A DOE Official...

  20. 10 CFR 820.8 - Evidentiary matters.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Evidentiary matters. 820.8 Section 820.8 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR DOE NUCLEAR ACTIVITIES General § 820.8 Evidentiary matters. (a... matter related to a DOE nuclear activity or for any decision required by this part. A DOE Official...

  1. 10 CFR 820.8 - Evidentiary matters.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Evidentiary matters. 820.8 Section 820.8 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR DOE NUCLEAR ACTIVITIES General § 820.8 Evidentiary matters. (a... matter related to a DOE nuclear activity or for any decision required by this part. A DOE Official...

  2. 10 CFR 820.8 - Evidentiary matters.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Evidentiary matters. 820.8 Section 820.8 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR DOE NUCLEAR ACTIVITIES General § 820.8 Evidentiary matters. (a... matter related to a DOE nuclear activity or for any decision required by this part. A DOE Official...

  3. 10 CFR 820.8 - Evidentiary matters.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Evidentiary matters. 820.8 Section 820.8 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR DOE NUCLEAR ACTIVITIES General § 820.8 Evidentiary matters. (a... matter related to a DOE nuclear activity or for any decision required by this part. A DOE Official...

  4. 10 CFR 780.8 - Security.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Security. 780.8 Section 780.8 Energy DEPARTMENT OF ENERGY PATENT COMPENSATION BOARD REGULATIONS General Provisions § 780.8 Security. In any proceeding under this... the Act to assure compliance with Department security regulations and the common defense....

  5. 10 CFR 216.8 - Communications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Communications. 216.8 Section 216.8 Energy DEPARTMENT OF ENERGY OIL MATERIALS ALLOCATION AND PRIORITY PERFORMANCE UNDER CONTRACTS OR ORDERS TO MAXIMIZE DOMESTIC ENERGY SUPPLIES § 216.8 Communications. All written communications concerning these regulations shall...

  6. 10 CFR 216.8 - Communications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Communications. 216.8 Section 216.8 Energy DEPARTMENT OF ENERGY OIL MATERIALS ALLOCATION AND PRIORITY PERFORMANCE UNDER CONTRACTS OR ORDERS TO MAXIMIZE DOMESTIC ENERGY SUPPLIES § 216.8 Communications. All written communications concerning these regulations shall...

  7. 10 CFR 780.8 - Security.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Security. 780.8 Section 780.8 Energy DEPARTMENT OF ENERGY PATENT COMPENSATION BOARD REGULATIONS General Provisions § 780.8 Security. In any proceeding under this... the Act to assure compliance with Department security regulations and the common defense....

  8. 10 CFR 780.8 - Security.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Security. 780.8 Section 780.8 Energy DEPARTMENT OF ENERGY PATENT COMPENSATION BOARD REGULATIONS General Provisions § 780.8 Security. In any proceeding under this... the Act to assure compliance with Department security regulations and the common defense....

  9. 10 CFR 780.8 - Security.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Security. 780.8 Section 780.8 Energy DEPARTMENT OF ENERGY PATENT COMPENSATION BOARD REGULATIONS General Provisions § 780.8 Security. In any proceeding under this... the Act to assure compliance with Department security regulations and the common defense....

  10. 9 CFR 354.10 - Inspection service.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Inspection service. 354.10 Section 354.10 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION VOLUNTARY INSPECTION...

  11. 9 CFR 354.10 - Inspection service.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Inspection service. 354.10 Section 354.10 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION...

  12. 9 CFR 146.10 - Supervision.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Supervision. 146.10 Section 146.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... authorize qualified persons as State Inspectors to perform the selecting and testing of participating...

  13. 9 CFR 146.10 - Supervision.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Supervision. 146.10 Section 146.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... authorize qualified persons as State Inspectors to perform the selecting and testing of participating...

  14. 9 CFR 146.10 - Supervision.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Supervision. 146.10 Section 146.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... authorize qualified persons as State Inspectors to perform the selecting and testing of participating...

  15. 9 CFR 590.10 - Authority.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Authority. 590.10 Section 590.10 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS... facilitate definite improvements and at the same time to maintain full compliance with the spirit and...

  16. 9 CFR 590.10 - Authority.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Authority. 590.10 Section 590.10 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS... facilitate definite improvements and at the same time to maintain full compliance with the spirit and...

  17. 9 CFR 167.10 - Stipulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Stipulations. 167.10 Section 167.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE SWINE HEALTH PROTECTION RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE SWINE HEALTH PROTECTION...

  18. 9 CFR 167.10 - Stipulations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Stipulations. 167.10 Section 167.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE SWINE HEALTH PROTECTION RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE SWINE HEALTH PROTECTION...

  19. 9 CFR 49.10 - Stipulations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Stipulations. 49.10 Section 49.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE COOPERATIVE CONTROL AND ERADICATION OF LIVESTOCK OR POULTRY DISEASES RULES OF PRACTICE GOVERNING...

  20. 9 CFR 49.10 - Stipulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Stipulations. 49.10 Section 49.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE COOPERATIVE CONTROL AND ERADICATION OF LIVESTOCK OR POULTRY DISEASES RULES OF PRACTICE GOVERNING...

  1. 9 CFR 12.10 - Stipulations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Stipulations. 12.10 Section 12.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE HORSE PROTECTION ACT Supplemental Rules...

  2. 9 CFR 12.10 - Stipulations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Stipulations. 12.10 Section 12.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE HORSE PROTECTION ACT Supplemental Rules...

  3. 9 CFR 592.10 - Authority.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Authority. 592.10 Section 592.10 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS... experimentation so that new procedures, equipment, and processing techniques may be tested to facilitate...

  4. 9 CFR 592.10 - Authority.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Authority. 592.10 Section 592.10 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS... experimentation so that new procedures, equipment, and processing techniques may be tested to facilitate...

  5. 9 CFR 590.10 - Authority.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Authority. 590.10 Section 590.10 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS... permit experimentation so that new procedures, equipment, and processing techniques may be tested...

  6. 9 CFR 590.10 - Authority.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Authority. 590.10 Section 590.10 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS... permit experimentation so that new procedures, equipment, and processing techniques may be tested...

  7. 40 CFR 10.9 - Penalties.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ADMINISTRATIVE CLAIMS UNDER FEDERAL TORT CLAIMS ACT Procedures § 10.9 Penalties. A person who files a false claim or makes a false or fraudulent statement in a claim against the United States may be liable to a fine of not more than $10,000 or...

  8. 40 CFR 10.9 - Penalties.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ADMINISTRATIVE CLAIMS UNDER FEDERAL TORT CLAIMS ACT Procedures § 10.9 Penalties. A person who files a false claim or makes a false or fraudulent statement in a claim against the United States may be liable to a fine of not more than $10,000 or...

  9. 40 CFR 10.9 - Penalties.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ADMINISTRATIVE CLAIMS UNDER FEDERAL TORT CLAIMS ACT Procedures § 10.9 Penalties. A person who files a false claim or makes a false or fraudulent statement in a claim against the United States may be liable to a fine of not more than $10,000 or...

  10. 9 CFR 592.10 - Authority.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Authority. 592.10 Section 592.10 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS... experimentation so that new procedures, equipment, and processing techniques may be tested to facilitate...

  11. 9 CFR 590.10 - Authority.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Authority. 590.10 Section 590.10 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS... permit experimentation so that new procedures, equipment, and processing techniques may be tested...

  12. 9 CFR 146.10 - Supervision.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Supervision. 146.10 Section 146.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... authorize qualified persons as State Inspectors to perform the selecting and testing of participating...

  13. 9 CFR 167.10 - Stipulations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Stipulations. 167.10 Section 167.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE SWINE HEALTH PROTECTION RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE SWINE HEALTH PROTECTION...

  14. 9 CFR 167.10 - Stipulations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Stipulations. 167.10 Section 167.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE SWINE HEALTH PROTECTION RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE SWINE HEALTH PROTECTION...

  15. 9 CFR 167.10 - Stipulations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Stipulations. 167.10 Section 167.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE SWINE HEALTH PROTECTION RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE SWINE HEALTH PROTECTION...

  16. 9 CFR 12.10 - Stipulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Stipulations. 12.10 Section 12.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE HORSE PROTECTION ACT Supplemental Rules...

  17. 9 CFR 4.10 - Summary action.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Summary action. 4.10 Section 4.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE ANIMAL WELFARE ACT Supplemental Rules...

  18. 9 CFR 4.10 - Summary action.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Summary action. 4.10 Section 4.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE ANIMAL WELFARE ACT Supplemental Rules...

  19. 9 CFR 4.10 - Summary action.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Summary action. 4.10 Section 4.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE ANIMAL WELFARE ACT Supplemental Rules...

  20. 9 CFR 4.10 - Summary action.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Summary action. 4.10 Section 4.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE ANIMAL WELFARE ACT Supplemental Rules...

  1. 9 CFR 4.10 - Summary action.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Summary action. 4.10 Section 4.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE ANIMAL WELFARE ACT Supplemental Rules...

  2. 8-9' linked neolignans with cytotoxicity from Alpinia conchigera.

    PubMed

    Xu, Jun-Ju; Zeng, Guang-Zhi; Yang, Sheng-Chao; Shen, Yong; Tan, Ning-Hua

    2013-12-01

    Five new 8-9' linked neolignans conchigeranals A-E (1-5), together with three known compounds galanganal (6), galanganols A (7) and B (8), were isolated from the whole plant of Alpinia conchigera. Their structures were established by spectroscopic analysis, including 2D-NMR spectroscopic techniques. Cytotoxicities of compounds 1-8 were tested against two cancer cell lines A549 and Hela. Results showed that 4, 5, 7 and 8 exhibited cytotoxicity against A549 with the IC50 values of 12.36, 9.72, 10.26, 13.05 μg/ml, respectively, and 1-8 against Hela with the IC50 values from 1.53 to 5.29 μg/ml.

  3. 8 CFR 245a.10 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Definitions. 245a.10 Section 245a.10 Aliens... AND NATIONALITY ACT Legal Immigration Family Equity (LIFE) Act Legalization Provisions § 245a.10 Definitions. In this Subpart B, the terms: Eligible alien means an alien (including a spouse or child...

  4. 8 CFR 245a.10 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Definitions. 245a.10 Section 245a.10 Aliens... IMMIGRATION AND NATIONALITY ACT Legal Immigration Family Equity (LIFE) Act Legalization Provisions § 245a.10 Definitions. In this Subpart B, the terms: Eligible alien means an alien (including a spouse or child...

  5. 8 CFR 245a.10 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Definitions. 245a.10 Section 245a.10 Aliens... AND NATIONALITY ACT Legal Immigration Family Equity (LIFE) Act Legalization Provisions § 245a.10 Definitions. In this Subpart B, the terms: Eligible alien means an alien (including a spouse or child...

  6. 8 CFR 245a.10 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Definitions. 245a.10 Section 245a.10 Aliens... AND NATIONALITY ACT Legal Immigration Family Equity (LIFE) Act Legalization Provisions § 245a.10 Definitions. In this Subpart B, the terms: Eligible alien means an alien (including a spouse or child...

  7. Carbon Dioxide, Hydrographic, and Chemical Data Obtained During the Nine R/V Korr Cruises Comprising the Indian Ocean CO2Survey (WOCE Sections I8SI9S, I9N, I8NI5E, I3, I5WI4, I7N, I1, I10, and I2; December 1, 1994-January 19, 1996)

    SciTech Connect

    Kozyr, A.V.

    2003-09-15

    This document describes the procedures and methods used to measure total carbon dioxide (TCO{sub 2}) and total alkalinity (TALK) at hydrographic stations taken during the R/V Knorr Indian Ocean cruises (Sections I8SI9S, I9N, I8NI5E, I3, I5WI4, I7N, I1, I10, and I2) in 1994-1996. The measurements were conducted as part of the World Ocean Circulation Experiment (WOCE). The expedition began in Fremantle, Australia, on December 1, 1994, and ended in Mombasa, Kenya, on January 22, 1996. During the nine cruises, 12 WOCE sections were occupied. Total carbon dioxide was extracted from water samples and measured using single-operator multiparameter metabolic analyzers (SOMMAs) coupled to coulometers. The overall precision and accuracy of the analyses was {+-} 1.20 {micro}mol/kg. The second carbonate system parameter, TALK, was determined by potentiometric titration. The precision of the measurements determined from 962 analyses of certified reference material was {+-} 4.2 {micro}mol/kg (REFERENCE). This work was supported by grants from the National Science Foundation, the U. S. Department of Energy, and the National Oceanographic and Atmospheric Administration. The R/V Knorr Indian Ocean data set is available as a numeric data package (NDP) from the Carbon Dioxide Information Analysis Center (CDIAC). The NDP consists of 18 oceanographic data files, two FORTRAN 77 data retrieval routine files, a readme file, and this printed documentation, which describes the contents and format of all files as well as the procedures and methods used to obtain the data. Instructions for accessing the data are provided.

  8. Influence of crystal characteristics on the shock sensitivities of cyclotrimethylene trinitramine, cyclotetramethylene tetranitramine, and 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazatetra-cyclo[5,5,0,03,1105,9]dodecane immersed in liquid

    NASA Astrophysics Data System (ADS)

    Li, Hongzhen; Xu, Rong; Kang, Bing; Li, Jinshan; Zhou, Xiaoqing; Zhang, Chaoyang; Nie, Fude

    2013-05-01

    The shock sensitivities of differently qualified cyclotrimethylene trinitramine (RDX), cyclotetramethylene tetranitramine(HMX), and 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazatetra-cyclo[5,5,0,03,1105,9]dodecane (CL-20) immersed in liquid were determined by the large-scale gap tests, for systemic discussion on the influences of crystal characteristics on them. As a result, it shows that (1) the immersion of crystals in liquid leads to an obvious sensitivity decrease; (2) for all three explosives, their shock sensitivities are lowered with increasing their crystal apparent densities or decreasing their particle sizes, and almost not affected by particle morphologies; (3) the crystal twins are readily formed for HMX and the most distinct factor influencing its shock sensitivities; (4) it is found that the crystal apparent density affects most obviously the shock sensitivities for RDX and CL-20; and (5) CL-20, HMX, and RDX are less and less sensitive to shock, suggesting chemical components are also a determining factor.

  9. RDamage 6, 7, 8 & 9 Cassettes

    SciTech Connect

    Griego, Jeffrey R; Kaul, Ann

    2012-06-08

    The RDamage series of ten experiments is part of a long-term collaboration with RFNC/VNIIEF in pulsed power technology. These experiments use a cylindrical configuration to study spallation damage, which allows for a natural recollection of the damaged material under proper driving conditions and post-shot collection of the damaged target material for subsequent metallographic analysis. Dynamic insitu experimental velocimetry diagnostics are also employed. LANL is responsible for the design of the experimental load and velocimetry system. VNIIEF is responsible for the design and construction of the driving explosive magnetic generator. In the RDamage-0, -1 and -2 experiments, data was collected about failure initiation of a well-characterized material (aluminum) in a cylindrical geometry. The RDamage-3, -4 and -5 experiments produced data on the behavior of material recollected after damage from pressures in the damage initiation regime. Data on the behavior of material recollected after complete failure was collected in the RDamage-6, -7, -8 and -9 experiments. This presentation shows the evolution of the load assembly through the experimental series.

  10. Oxidative Damage to Nucleic Acids and Benzo(a)pyrene-7,8-diol-9,10-epoxide-DNA Adducts and Chromosomal Aberration in Children with Psoriasis Repeatedly Exposed to Crude Coal Tar Ointment and UV Radiation

    PubMed Central

    Andrys, Ctirad; Palicka, Vladimir; Chmelarova, Marcela; Hamakova, Kvetoslava

    2014-01-01

    The paper presents a prospective cohort study. Observed group was formed of children with plaque psoriasis (n=19) treated by Goeckerman therapy (GT). The study describes adverse (side) effects associated with application of GT (combined exposure of 3% crude coal tar ointment and UV radiation). After GT we found significantly increased markers of oxidative stress (8-hydroxy-2′-deoxyguanosine, 8-hydroxyguanosine, and 8-hydroxyguanine), significantly increased levels of benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE) DNA adducts (BPDE-DNA), and significantly increased levels of total number of chromosomal aberrations in peripheral lymphocytes. We found significant relationship between (1) time of UV exposure and total number of aberrated cells and (2) daily topical application of 3% crude coal tar ointment (% of body surface) and level of BPDE-DNA adducts. The findings indicated increased hazard of oxidative stress and genotoxic effects related to the treatment. However, it must be noted that the oxidized guanine species and BPDE-DNA adducts also reflect individual variations in metabolic enzyme activity (different extent of bioactivation of benzo[a]pyrene to BPDE) and overall efficiency of DNA/RNA repair system. The study confirmed good effectiveness of the GT (significantly decreased PASI score). PMID:25197429

  11. 8 CFR 103.10 - Precedent decisions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... General are governed by part 1003 of 8 CFR chapter V. (b) Decisions as precedents. Except as Board... provided in paragraph (c) of this section or 8 CFR 1003.1(h)(2). (d) Publication of Secretary's precedent...; BIOMETRIC REQUIREMENTS; AVAILABILITY OF RECORDS Applying for Benefits, Surety Bonds, Fees § 103.10...

  12. 8 CFR 103.10 - Precedent decisions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... General are governed by part 1003 of 8 CFR chapter V. (b) Decisions as precedents. Except as Board... provided in paragraph (c) of this section or 8 CFR 1003.1(h)(2). (d) Publication of Secretary's precedent...; BIOMETRIC REQUIREMENTS; AVAILABILITY OF RECORDS Applying for Benefits, Surety Bonds, Fees § 103.10...

  13. 8 CFR 103.10 - Precedent decisions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... General are governed by part 1003 of 8 CFR chapter V. (b) Decisions as precedents. Except as Board... provided in paragraph (c) of this section or 8 CFR 1003.1(h)(2). (d) Publication of Secretary's precedent...; BIOMETRIC REQUIREMENTS; AVAILABILITY OF RECORDS Applying for Benefits, Surety Bonds, Fees § 103.10...

  14. 10 CFR 710.8 - Criteria.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Criteria. 710.8 Section 710.8 Energy DEPARTMENT OF ENERGY CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO CLASSIFIED MATTER OR SPECIAL NUCLEAR... Special Nuclear Material Criteria and Procedures for Determining Eligibility for Access to...

  15. 10 CFR 710.8 - Criteria.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Criteria. 710.8 Section 710.8 Energy DEPARTMENT OF ENERGY CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO CLASSIFIED MATTER OR SPECIAL NUCLEAR... Special Nuclear Material Criteria and Procedures for Determining Eligibility for Access to...

  16. 10 CFR 710.8 - Criteria.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Criteria. 710.8 Section 710.8 Energy DEPARTMENT OF ENERGY CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO CLASSIFIED MATTER OR SPECIAL NUCLEAR... Special Nuclear Material Criteria and Procedures for Determining Eligibility for Access to...

  17. 32 CFR 9.10 - Other.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... requirement of the United States Constitution. Section and subsection captions in this document are for... MILITARY COMMISSIONS OF CERTAIN NON-UNITED STATES CITIZENS IN THE WAR AGAINST TERRORISM § 9.10 Other. This..., enforceable by any party, against the United States, its departments, agencies, or other......

  18. 32 CFR 9.10 - Other.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... requirement of the United States Constitution. Section and subsection captions in this document are for... Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS PROCEDURES FOR TRIALS BY MILITARY COMMISSIONS OF CERTAIN NON-UNITED STATES CITIZENS IN THE WAR AGAINST TERRORISM § 9.10 Other....

  19. 32 CFR 9.10 - Other.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... requirement of the United States Constitution. Section and subsection captions in this document are for... Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS PROCEDURES FOR TRIALS BY MILITARY COMMISSIONS OF CERTAIN NON-UNITED STATES CITIZENS IN THE WAR AGAINST TERRORISM § 9.10 Other....

  20. 32 CFR 9.10 - Other.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... requirement of the United States Constitution. Section and subsection captions in this document are for... Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS PROCEDURES FOR TRIALS BY MILITARY COMMISSIONS OF CERTAIN NON-UNITED STATES CITIZENS IN THE WAR AGAINST TERRORISM § 9.10 Other....

  1. Design, synthesis and biological evaluation of novel 6H-benzo[c]chromen-6-one, and 7,8,9,10-tetrahydro-benzo[c]chromen-6-one derivatives as potential cholinesterase inhibitors.

    PubMed

    Gulcan, Hayrettin Ozan; Unlu, Serdar; Esiringu, Ilker; Ercetin, Tugba; Sahin, Yasemin; Oz, Demet; Sahin, Mustafa Fethi

    2014-10-01

    Hydroxylated 6H-benzo[c]chromen-6-one derivatives (i.e., urolithins) are the main bioavailable metabolites, and biomarkers of ellagitannins present in various nutrition. Although these dietaries, the sources of urolithins, are employed in folk medicine as cognitive enhancer in the treatment of Alzheimer's Disease, urolithins have negligible potential to inhibit acetylcholinesterase and butyrylcholinesterase enzymes, the validated targets of Alzheimer's Disease. Therefore, within this research, a series of 6H-benzo[c]chromen-6-one, and 7,8,9,10-tetrahydro-benzo[c]chromen-6-one derivatives has been designed, synthesized, and their biological activities were evaluated as potential acetylcholinesterase and butyrylcholinesterase inhibitors. The compounds synthesized exerted comparable activity in comparison to rivastigmine, galantamine, and donepezil both in in vitro and in vivo studies.

  2. Photochemistry of tricyclo[5.2.2.0(2,6)]undeca-4,10-dien-8-ones: an efficient general route to substituted linear triquinanes from 2-methoxyphenols. Total synthesis of (+/-)-Delta(9(12))-capnellene.

    PubMed

    Hsu, Day-Shin; Chou, Yu-Yu; Tung, Yen-Shih; Liao, Chun-Chen

    2010-03-01

    An efficient and short entry to polyfunctionalized linear triquinanes from 2-methoxyphenols is described by utilizing the following chemistry. The Diels-Alder reactions of masked o-benzoquinones, derived from 2-methoxyphenols, with cyclopentadiene afford tricyclo[5.2.2.0(2,6)]undeca-4,10-dien-8-ones. Photochemical oxa-di-pi-methane (ODPM) rearrangements and 1,3-acyl shifts of the Diels-Alder adducts are investigated. The ODPM-rearranged products are further converted to linear triquinanes by using an O-stannyl ketyl fragmentation. Application of this efficient strategy to the total synthesis of (+/-)-Delta(9(12))-capnellene was accomplished from 2-methoxy-4-methylphenol in nine steps with 20 % overall yield.

  3. Design, synthesis and biological evaluation of novel 6H-benzo[c]chromen-6-one, and 7,8,9,10-tetrahydro-benzo[c]chromen-6-one derivatives as potential cholinesterase inhibitors.

    PubMed

    Gulcan, Hayrettin Ozan; Unlu, Serdar; Esiringu, Ilker; Ercetin, Tugba; Sahin, Yasemin; Oz, Demet; Sahin, Mustafa Fethi

    2014-10-01

    Hydroxylated 6H-benzo[c]chromen-6-one derivatives (i.e., urolithins) are the main bioavailable metabolites, and biomarkers of ellagitannins present in various nutrition. Although these dietaries, the sources of urolithins, are employed in folk medicine as cognitive enhancer in the treatment of Alzheimer's Disease, urolithins have negligible potential to inhibit acetylcholinesterase and butyrylcholinesterase enzymes, the validated targets of Alzheimer's Disease. Therefore, within this research, a series of 6H-benzo[c]chromen-6-one, and 7,8,9,10-tetrahydro-benzo[c]chromen-6-one derivatives has been designed, synthesized, and their biological activities were evaluated as potential acetylcholinesterase and butyrylcholinesterase inhibitors. The compounds synthesized exerted comparable activity in comparison to rivastigmine, galantamine, and donepezil both in in vitro and in vivo studies. PMID:25189690

  4. 8. Granite quay wall at foot of Pier 10 (west ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Granite quay wall at foot of Pier 10 (west end), view to north, at low tide. - Charlestown Navy Yard, Pier 10, Between Piers 9 & 11 along Mystic River on Charlestown Waterfront at eastern edge of Charlestown Navy Yard, Boston, Suffolk County, MA

  5. In vitro replication by prokaryotic and eukaryotic polymerases on DNA templates containing site-specific and stereospecific benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide adducts.

    PubMed

    Chary, P; Lloyd, R S

    1995-04-25

    DNA adducts of the environmental carcinogen benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE) interact stereospecifically with prokaryotic and eukaryotic polymerases in vitro. Toward understanding the capacity to replicate past different diastereomers of BPDE at specific sites in DNA, six deoxyoligonucleotides, each 33 bases long, were constructed with stereochemically defined BPDE adducts on adenine N6 at position two of the human N-ras codon 61. Four polymerases that were studied under single encounters with the template-primer complex terminated synthesis one base 3' to the lesion with all the adducted templates. When multiple encounters between polymerase and substrate were permitted, each of the polymerases analyzed revealed a unique pattern for a given adducted template. The general replication pattern was encompassed under two categories, reflecting the significance of the R and S configurations of C10 of the pyrenyl ring attached to the single-stranded DNA template. Furthermore, within each of these categories, every polymerase demonstrated distinct quantitative differences in product accumulation at a given site, for the various adducted templates. Among the polymerases utilized in this study, exonuclease-deficient Klenow fragment of polymerase I (exo- KF) exhibited the most efficient translesion synthesis resulting in approximately 16% full-length products with the modified templates bearing adducts with C10-S configuration. In contrast, chain elongation with bacteriophage T4 DNA polymerase bearing an active 3'-->5' exonucleolytic activity was most strongly inhibited by all six BPDE-adducted templates. Misincorporation of A opposite the adduct occurred in all the templates when polymerized with Sequenase, whereas exo- KF preferentially incorporated C opposite the C10-R BPDE adducts and A opposite the C10-S BPDE adducts.

  6. Induction of nitric oxide production by the cytostatic macrolide apicularen A [2,4-heptadienamide, N-[(1E)-3-[(3S,5R,7R,9S)-3,4,5,6,7,8,9,10-octahydro-7,14 dihydroxy-1-oxo-5,9-epoxy-1H-2-benzoxacyclododecin-3-yl]-1 propenyl]-, (2Z,4Z)-(9CI)] and possible role of nitric oxide in apicularen A-induced apoptosis in RAW 264.7 cells.

    PubMed

    Hong, JangJa; Yokomakura, Aya; Nakano, Yasuhiro; Ban, Hyun Seung; Ishihara, Kenji; Ahn, Jong-Woong; Zee, OkPyo; Ohuchi, Kazuo

    2005-03-01

    We previously reported that apicularen A [2,4-heptadienamide, N-[(1E)-3-[(3S,5R,7R,9S)-3,4,5,6,7,8,9,10-octahydro-7,14 dihydroxy-1-oxo-5,9-epoxy-1H-2-benzoxacyclododecin-3-yl]-1 propenyl]-, (2Z,4Z)-(9CI)], a highly cytostatic macrolide isolated from the myxobacterial genus Chondromyces, induces apoptosis in the mouse leukemic monocyte cell line RAW 264.7. To analyze the action mechanism of apicularen A for the induction of apoptosis, effects of apicularen A on nitric oxide (NO) production in RAW 264.7 cells were examined. It was demonstrated that apicularen A at 10 and 100 nM induced nitrite production, whereas apicularen B [2,4-heptadienamide, N-[(1E)-3-[(3S,5R,7R,9S)-7-[[2-(acetylamino)-2-deoxy-beta-d-glucopyranosyl]oxy]-3,4,5,6,7,8,9,10-octahydro-14-hydroxy-1-oxo-5,9-epoxy-1H-2-benzoxacyclododecin-3-yl]-1 propenyl]-, (2Z,4Z)-(9CI)], an N-acetyl-glucosamine glycoside of apicularen A, had no effect at 100 nM. The apicularen A-induced nitrite production was accompanied by an increase in the level of inducible nitric-oxide synthase (iNOS) and its mRNA and was suppressed by the NOS inhibitor N(G)-monomethyl-l-arginine acetate (l-NMMA). In addition, apicularen A activated nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1) and decreased the level of IkappaB-alpha and increased that of phosphorylated c-Jun N-terminal kinase (JNK). Furthermore, the apicularen A-induced nitrite production was suppressed by the NF-kappaB inhibitor Bay 11-7082 [(E)-3-(4-methylphenylsulfonyl)-2-propenenitrile] and the JNK inhibitor SP600125 [anthra[1,9-cd]pyrazol-6(2H)-one]. These findings suggested that apicularen A activates NF-kappaB and AP-1, thus triggering the expression of iNOS mRNA and iNOS protein and induces NO production. Finally, apicularen A decreased cell growth and survival and cell viability and disrupted the mitochondrial membrane potential. The addition of l-NMMA partially recovered the apicularen A-induced decrease in cell growth and survival and cell

  7. 9 CFR 417.8 - Agency verification.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ANALYSIS AND CRITICAL CONTROL POINT (HACCP) SYSTEMS § 417.8 Agency verification. FSIS will verify the... plan or system; (f) Direct observation or measurement at a CCP; (g) Sample collection and analysis...

  8. 9 CFR 417.8 - Agency verification.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ANALYSIS AND CRITICAL CONTROL POINT (HACCP) SYSTEMS § 417.8 Agency verification. FSIS will verify the... plan or system; (f) Direct observation or measurement at a CCP; (g) Sample collection and analysis...

  9. Photocopy of drawing (this photograph is an 8' x 10' ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing (this photograph is an 8' x 10' copy of an 8' x 10' negative; 1952 original architectural drawing located at Building No. 458, NAS Pensacola, Florida) Conversion of Building No. 18 for overhaul and repair department electronics shop, existing first and second floor plan, sheet 9 of 21 - U.S. Naval Air Station, Marine Barracks, 232 East Avenue, Pensacola, Escambia County, FL

  10. 10 CFR 605.8 - Solicitation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... § 605.8 Solicitation. (a) The Catalog of Federal Domestic Assistance number for this program is 81.049, and its solicitation control number is ERFAP 10 CFR part 605. (b) An application for a new or renewal...) Each notice of availability shall cite this part and shall include: (i) The Catalog of Federal...

  11. 15 CFR 10.8 - Standing Committee.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... PRODUCT STANDARDS § 10.8 Standing Committee. (a) The Department shall establish and appoint the members of..., distributors, and users or consumers of the product covered by the standard, and representatives of appropriate...) The product or products covered by the standard; (2) The standard itself; and (3) Industry and...

  12. DFT studies on a high-energy density cage compound 1, 3, 5, 7, 9, 11-hexo(N(CH3)NO2)-2, 4, 6, 8, 10, 12-hexaazatetracyclo[5, 5, 0, 0, 0] dodecane

    NASA Astrophysics Data System (ADS)

    Li, Xiao-Hong; Yong, Yong-Liang; Zhang, Xian-Zhou

    2014-04-01

    The infrared and Raman spectra, heat of formation (HOF) and thermodynamic properties were investigated by B3LYP/6-31G** method for a new designed polynitro cage compound 1,3,5,7,9,11-hexo(N(CH3)NO2)-2,4,6,8,10,12-hexaazatetracyclo[5,5,0,0,0]dodecane. The detonation velocity (D) and pressure (P) were predicted by the Kamlet-Jacobs equations based on the theoretical density and condensed HOF. The bond dissociation energies and bond orders for the weakest bonds were analysed to investigate the thermal stability of the title compound. The computational result shows that the detonation velocity and pressure of the title compound are superior to those of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), but inferior to those of 1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane (HMX) and hexanitrohexaazaisowurtzitane (HNIW). And the analysis of thermal stability shows that the first step of pyrolysis is the rupture of the N7-NO2 bond. The crystal structure obtained by molecular mechanics belongs to the P21 space group, with the lattice parameters Z = 2, a = 11.8246 Å, b = 10.4632 Å, c = 15.9713 Å, ρ = 1.98 g cm-3.

  13. 36 CFR 9.8 - Use of water.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Use of water. 9.8 Section 9.8... MANAGEMENT Mining and Mining Claims § 9.8 Use of water. (a) No operator may use for operations any water from... Regional Director. The Regional Director shall not approve a plan of operations requiring the use of...

  14. 38 CFR 8.9 - Application and medical evidence.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false Application and medical evidence. 8.9 Section 8.9 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS NATIONAL SERVICE LIFE INSURANCE Reinstatement § 8.9 Application and medical evidence. The applicant...

  15. 38 CFR 8.9 - Application and medical evidence.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false Application and medical evidence. 8.9 Section 8.9 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS NATIONAL SERVICE LIFE INSURANCE Reinstatement § 8.9 Application and medical evidence. The applicant...

  16. 38 CFR 8.9 - Application and medical evidence.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2012-07-01 2012-07-01 false Application and medical evidence. 8.9 Section 8.9 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS NATIONAL SERVICE LIFE INSURANCE Reinstatement § 8.9 Application and medical evidence. The applicant...

  17. 7 CFR 319.56-8-319.56-9 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false 319.56-8-319.56-9 Section 319.56-8-319.56-9 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOREIGN QUARANTINE NOTICES Fruits and Vegetables §§ 319.56-8—319.56-9...

  18. 28 CFR 8.9 - Disposition of forfeited property.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Disposition of forfeited property. 8.9 Section 8.9 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN STATUTES § 8.9 Disposition of forfeited property. (a) If the laws of a state in which an article of...

  19. 28 CFR 8.9 - Disposition of forfeited property.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Disposition of forfeited property. 8.9 Section 8.9 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN STATUTES § 8.9 Disposition of forfeited property. (a) If the laws of a state in which an article of...

  20. 28 CFR 8.9 - Disposition of forfeited property.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Disposition of forfeited property. 8.9 Section 8.9 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN STATUTES § 8.9 Disposition of forfeited property. (a) If the laws of a state in which an article of...

  1. 38 CFR 9.8 - Termination of coverage.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false Termination of coverage. 9.8 Section 9.8 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS SERVICEMEMBERS' GROUP LIFE INSURANCE AND VETERANS' GROUP LIFE INSURANCE § 9.8 Termination of...

  2. 38 CFR 9.8 - Termination of coverage.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false Termination of coverage. 9.8 Section 9.8 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS SERVICEMEMBERS' GROUP LIFE INSURANCE AND VETERANS' GROUP LIFE INSURANCE § 9.8 Termination of...

  3. 38 CFR 9.8 - Termination of coverage.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Termination of coverage. 9.8 Section 9.8 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS SERVICEMEMBERS' GROUP LIFE INSURANCE AND VETERANS' GROUP LIFE INSURANCE § 9.8 Termination of...

  4. 30 CFR 402.8-402.9 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 2 2012-07-01 2012-07-01 false 402.8-402.9 Section 402.8-402.9 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH PROGRAM AND THE WATER-RESOURCES TECHNOLOGY DEVELOPMENT PROGRAM Description of Water-Resources Programs §§ 402.8-402.9...

  5. 30 CFR 402.8-402.9 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false 402.8-402.9 Section 402.8-402.9 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH PROGRAM AND THE WATER-RESOURCES TECHNOLOGY DEVELOPMENT PROGRAM Description of Water-Resources Programs §§ 402.8-402.9...

  6. 30 CFR 402.8-402.9 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 2 2014-07-01 2014-07-01 false 402.8-402.9 Section 402.8-402.9 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH PROGRAM AND THE WATER-RESOURCES TECHNOLOGY DEVELOPMENT PROGRAM Description of Water-Resources Programs §§ 402.8-402.9...

  7. 38 CFR 8.9 - Application and medical evidence.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Application and medical evidence. 8.9 Section 8.9 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS NATIONAL SERVICE LIFE INSURANCE Reinstatement § 8.9 Application and medical evidence. The applicant...

  8. 36 CFR 8.9 - Posting of regulations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Posting of regulations. 8.9 Section 8.9 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR LABOR STANDARDS APPLICABLE TO EMPLOYEES OF NATIONAL PARK SERVICE CONCESSIONERS § 8.9 Posting of...

  9. 30 CFR 402.8-402.9 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false 402.8-402.9 Section 402.8-402.9 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH PROGRAM AND THE WATER-RESOURCES TECHNOLOGY DEVELOPMENT PROGRAM Description of Water-Resources Programs §§ 402.8-402.9...

  10. 30 CFR 402.8-402.9 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false 402.8-402.9 Section 402.8-402.9 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH PROGRAM AND THE WATER-RESOURCES TECHNOLOGY DEVELOPMENT PROGRAM Description of Water-Resources Programs §§ 402.8-402.9...

  11. 9 CFR 104.8 - Illegal shipments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS PERMITS FOR BIOLOGICAL PRODUCTS § 104.8 Illegal shipments. (a) Biological products which are presented for importation without a permit...

  12. 9 CFR 98.8 - Inspection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... EMBRYOS AND ANIMAL SEMEN Ruminant and Swine Embryos from Regions Free of Rinderpest and Foot-and-Mouth Disease; and Embryos of Horses and Asses § 98.8 Inspection. Any embryo offered for entry into the United States in accordance with this subpart and documents accompanying the embryo shall be subject...

  13. 9 CFR 98.8 - Inspection.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... EMBRYOS AND ANIMAL SEMEN Ruminant and Swine Embryos from Regions Free of Rinderpest and Foot-and-Mouth Disease; and Embryos of Horses and Asses § 98.8 Inspection. Any embryo offered for entry into the United States in accordance with this subpart and documents accompanying the embryo shall be subject...

  14. 9 CFR 98.8 - Inspection.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... EMBRYOS AND ANIMAL SEMEN Ruminant and Swine Embryos from Regions Free of Rinderpest and Foot-and-Mouth Disease; and Embryos of Horses and Asses § 98.8 Inspection. Any embryo offered for entry into the United States in accordance with this subpart and documents accompanying the embryo shall be subject...

  15. 9 CFR 98.8 - Inspection.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... EMBRYOS AND ANIMAL SEMEN Ruminant and Swine Embryos from Regions Free of Rinderpest and Foot-and-Mouth Disease; and Embryos of Horses and Asses § 98.8 Inspection. Any embryo offered for entry into the United States in accordance with this subpart and documents accompanying the embryo shall be subject...

  16. 9 CFR 98.8 - Inspection.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... EMBRYOS AND ANIMAL SEMEN Ruminant and Swine Embryos from Regions Free of Rinderpest and Foot-and-Mouth Disease; and Embryos of Horses and Asses § 98.8 Inspection. Any embryo offered for entry into the United States in accordance with this subpart and documents accompanying the embryo shall be subject...

  17. Among substituted 9,10-dihydro-9,10-[1,2]benzenoanthracene-1,4,5,8-tetraones, the lead antitumor triptycene bisquinone TT24 blocks nucleoside transport, induces apoptotic DNA fragmentation and decreases the viability of L1210 leukemic cells in the nanomolar range of daunorubicin in vitro.

    PubMed

    Perchellet, Elisabeth M; Sperfslage, Bonnie J; Wang, Yang; Huang, Xiaodong; Tamura, Masafumi; Hua, Duy H; Perchellet, Jean-Pierre

    2002-07-01

    In contrast to their inactive parent compound triptycene (code name TT0), several new synthetic analogs (TT code number) have antileukemic activities and remain effective in daunorubicin (DAU)-resistant tumor sublines in vitro. Among variously substituted 9,10-dihydro-9,10-[1,2]benzenoanthracene-1,4,5,8-tetraones, a total of six lead antitumor compounds have been identified, and their code names are TT2, TT13, TT16, TT19, TT21 and TT24. These active antitumor triptych structures have bisquinone functionality, and various bromo, methoxy, methylamino and/or dimethylamino substitutions with or without longer alkyl chains on the amino function. Like the anthracycline quinone antibiotic DAU, these triptycene (TT) bisquinones also inhibit DNA synthesis and induce DNA cleavage in relation with their cytotoxic activities, but have the additional advantage of blocking the cellular transport of purine and pyrimidine nucleosides, an effect which DAU cannot do. As demonstrated by intact chromatin precipitation and agarose gel electrophoresis, the ability of TT bisquinones and DAU to induce DNA fragmentation is biphasic with a peak that shifts to lower concentrations with increasing times of drug exposure. The most effective lead antitumor compound, TT24, induces DNA cleavage in the same concentration-dependent manner as DAU at 24 h (similar peak in response to 1.6 microM) and is nearly equipotent to DAU against L1210 tumor cell viability at day 4 (IC50 values of TT24 and DAU: 48 and 25 nM, respectively). The mechanism by which TT24 induces DNA fragmentation is inhibited by actinomycin D, cycloheximide, benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone, benzyloxycarbonyl-Ile-Glu-Thr-Asp-fluoromethyl ketone, N-tosyl-L-phenylalanine chloromethyl ketone and ZnSO4, suggesting that TT bisquinones trigger apoptosis by caspase and endonuclease activation. Since TT24 is cytotoxic in the nanomolar range of DAU, but might have a more versatile mechanism of action than DAU in wild

  18. Converting ICD-9 to ICD-10.

    PubMed

    Stephens, James H; Ledlow, Gerald R; Fockler, Thomas V

    2016-01-01

    Implementing the International Classification of Diseases, Ninth Revision (ICD-9) to International Classification of Diseases, Tenth Revision (ICD-10) conversion on October 1, 2015, in the United States has been a long-term goal. While most countries in the world converted more than 10 years ago, the United States was still using ICD-9. Many countries in the world have a single-payer healthcare system, while there are thousands of different healthcare organizations (providers and payers) that presently exist in the United States. With so many different software platforms for healthcare providers and payers, the conversion had become that much more complicated and capital intensive for all healthcare organizations in the country. A few of the present delay reasons to the ICD-10 conversion in past years were the concurrent timelines for meeting meaningful use requirements for the electronic health record, testing with external payers and upgrades from vendors which added complexities and extra costs. The authors examine the reasoning behind the conversion as well as the delays, before making the conversion on October 1, 2015, and review the question regarding whether the government's decision to push the date back a year would have been helpful. PMID:26980201

  19. Investigation of spin reorientation in YMn1-xFexO3 (x = 0.55, 0.6, 0.7, 0.8, 0.9, and 1.0) by Mössbauer spectroscopy

    NASA Astrophysics Data System (ADS)

    Lim, Jung Tae; Choi, Young Jai; Kim, Chul Sung

    2015-05-01

    YMn1-xFexO3 (x = 0.55, 0.6, 0.7, 0.8, 0.9, and 1.0) polycrystalline samples were prepared by the solid-state-reaction method. The crystal structure and magnetic properties of samples were investigated with x-ray diffractometer (XRD), vibrating sample magnetometer, and Mössbauer spectroscopy. The XRD patterns at 295 K, analyzed by Rietveld refinement method, showed that all samples were single-phased orthorhombic of Pnma with both Bragg (RB) and structure (RF) factors less than 5%. Mössbauer spectra of all samples were obtained at various temperatures ranging from 4.2 to 500 K, and the spectra below TC were fitted by least-square method as a function of the Fe and Mn distribution. Isomer shift (δ) values of all samples indicated that the charge states were Fe3+. In addition, temperature-dependent hyperfine field (Hhf), averaged electric quadrupole shift , and averaged isomer shift <δ> have shown abrupt changes around TSR due to the change in the charge state of Mn ions.

  20. Induction of Cell Death, DNA Strand Breaks, and Cell Cycle Arrest in DU145 Human Prostate Carcinoma Cell Line by Benzo[a]pyrene and Benzo[a]pyrene-7,8-diol-9,10-epoxide

    PubMed Central

    Nwagbara, Onyinye; Darling-Reed, Selina F.; Tucker, Alicia; Harris, Cynthia; Abazinge, Michael; Thomas, Ronald D.; Gragg, Richard D.

    2007-01-01

    Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon, is a major environmental pollutant. In this study, the effects of this carcinogen/mutagen and one of its metabolites, benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE), on human prostate carcinoma cell line DU145, were examined. Cell viability, DNA damage, and cell cycle progression were evaluated as toxic end-points. We have shown that B[a]P and BPDE inhibited cell viability following 48 hr of exposure. Furthermore, comet assay analyses revealed that both B[a]P and BPDE induced DNA strand breaks in a concentration -dependent fashion. Flow cytometric analyses showed that about 70 % of DU145 cells were arrested by B[a]P at the G1 phase, while about 76% were arrested at G1 phase by BPDE. These data reveal that B[a]P and BPDE are cytotoxic and genotoxic to DU145 prostate cancer cells. PMID:17431309

  1. A Photometric Study of Four Recently Discovered Contact Binaries: 1SWASP J064501.21+342154.9, 1SWASP J155822.10-025604.8, 1SWASP J212808.86+151622.0, and UCAC4 436-062932

    NASA Astrophysics Data System (ADS)

    Djurašević, G.; Essam, A.; Latković, O.; Cséki, A.; El-Sadek, M. A.; Abo-Elala, M. S.; Hayman, Z. M.

    2016-09-01

    We present new, high-quality multicolor observations of four recently discovered contact binaries, 1SWASP J064501.21+342154.9, 1SWASP J155822.10-025604.8, 1SWASP J212808.86+151622.0, and UCAC4 436-062932, and analyze their light curves to determine orbital and physical parameters using the modeling program of G. Djurašević. In the absence of spectroscopic observations, the effective temperatures of the brighter components are estimated from the color indices, and the mass ratios are determined with the q-search method. The analysis shows that all four systems are W UMa type binaries in shallow contact configurations, consisting of late-type main-sequence primaries and evolved secondaries with active surface regions (dark or bright spots) resulting from magnetic activity or ongoing transfer of thermal energy between the components. We compare the derived orbital and stellar parameters for these four variables with a large sample of previously analyzed W UMa stars and find that our results fit it well.

  2. Spectral, structural elucidation and coordination abilities of Co(II) and Mn(II) coordination entities of 2,6,11,15-tetraoxa-9,17-diaza-1,7,10,16-(1,2)-tetrabenzenacyclooctadecaphan-8,17-diene.

    PubMed

    Rajiv, Kumar; Rajni, Johar

    2011-09-01

    Designing tactics were tailored and followed by synthetic and formulation methodologies to prepare 2,6,11,15-tetraoxa-9,17-diaza-1,7,10,16-(1,2)-tetrabenzenacyclooctadecaphan-8,17-diene. Spectral techniques (MS, infrared, 1H NMR, 13C NMR, electronic and EPR), physiochemical measurements (elemental analysis, molar conductance and magnetic susceptibility), electrochemistry (cyclic voltammetry) and classical mechanics (molecular modeling) were employed for structural elucidation of Co(II) and Mn(II) coordination entities having N2O4 chromophore. Comparative spectral analysis revealed legating nature of N2O4 donor macrocycle and confirmed host/guest connectivity between ligand and metal(s). Mass spectrometry (MS) determined 1:1 stoichiometry in CEs. Further electrochemical study confirmed change in oxidation and reduction patterns of CEs. Inhibiting potential (antifungal screened against Aspergillus flavus) showed enhanced antimicrobial properties of CEs as compared to ligand. Molecular modeling was employed to find out different molecular features along with their stabilization energies.

  3. 8 CFR 1337.9 - Effective date of naturalization.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... administrative ceremony or in a ceremony conducted by an appropriate court under § 1337.8 of 8 CFR chapter I. (b) ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Effective date of naturalization. 1337.9... NATIONALITY REGULATIONS OATH OF ALLEGIANCE § 1337.9 Effective date of naturalization. (a) An applicant...

  4. 8 CFR 1337.9 - Effective date of naturalization.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... administrative ceremony or in a ceremony conducted by an appropriate court under § 1337.8 of 8 CFR chapter I. (b) ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Effective date of naturalization. 1337.9... NATIONALITY REGULATIONS OATH OF ALLEGIANCE § 1337.9 Effective date of naturalization. (a) An applicant...

  5. 8 CFR 1337.9 - Effective date of naturalization.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... administrative ceremony or in a ceremony conducted by an appropriate court under § 1337.8 of 8 CFR chapter I. (b) ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Effective date of naturalization. 1337.9... NATIONALITY REGULATIONS OATH OF ALLEGIANCE § 1337.9 Effective date of naturalization. (a) An applicant...

  6. 8 CFR 1337.9 - Effective date of naturalization.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... administrative ceremony or in a ceremony conducted by an appropriate court under § 1337.8 of 8 CFR chapter I. (b) ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Effective date of naturalization. 1337.9... NATIONALITY REGULATIONS OATH OF ALLEGIANCE § 1337.9 Effective date of naturalization. (a) An applicant...

  7. 8 CFR 1337.9 - Effective date of naturalization.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... administrative ceremony or in a ceremony conducted by an appropriate court under § 1337.8 of 8 CFR chapter I. (b) ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Effective date of naturalization. 1337.9... NATIONALITY REGULATIONS OATH OF ALLEGIANCE § 1337.9 Effective date of naturalization. (a) An applicant...

  8. 8. Building G9; view of No. 8 condenser and top ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Building G-9; view of No. 8 condenser and top of dissolve tank; third floor, looking S. (Ryan) - Holston Army Ammunition Plant, RDX-and-Composition-B Manufacturing Line 9, Kingsport, Sullivan County, TN

  9. Genetic polymorphisms in biotransformation enzymes for benzo[a]pyrene and related levels of benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA adducts in Goeckerman therapy.

    PubMed

    Beranek, Martin; Fiala, Zdenek; Kremlacek, Jan; Andrys, Ctirad; Hamakova, Kvetoslava; Chmelarova, Marcela; Palicka, Vladimir; Borska, Lenka

    2016-07-25

    Goeckerman therapy (GT) for psoriasis combines the therapeutic effect of crude coal tar (CCT) and ultraviolet radiation (UVR). CCT contains polycyclic aromatic hydrocarbons, some of which can form DNA adducts that may induce mutations and contribute to carcinogenesis. The aim of our work was to evaluate the relationship between concentrations of benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA adducts (BPDE-DNA adducts) and rs4646903 (CYP1A1 gene), rs1048943 (CYP1A1), rs1056836 (CYP1B1), rs1051740 (EPHX1), rs2234922 (EPHX1) and rs8175347 (UGT1A1) polymorphic sites, and GSTM1 null polymorphism in 46 patients with chronic stable plaque psoriasis who underwent GT. The level of BPDE-DNA adducts was determined using the OxiSelect BPDE-DNA Adduct ELISA Kit. Polymerase chain reaction (PCR) and restriction fragment length polymorphism analysis (rs4646903, rs1048943, rs1051740, and rs2234922), fragment analysis (rs8175347), real-time PCR (rs1056836), and digital droplet PCR polymorphism (GSTM1) were used. CYP1B1*1/*1 wild-type subjects and CYP1B1*3/*1 heterozygotes for rs1056836 formed significantly higher amounts of BPDE-DNA adducts than CYP1B1*3/*3 homozygotes (p=0.031 and p=0.005, respectively). Regarding rs1051740, individuals with EPHX1*3/*1 heterozygosity revealed fewer adducts than EPHX1*1/*1 wild-type subjects (p=0.026). Our data suggest that CYP1B1/EPHX1 genotyping could help to predict the risk of DNA damage and to optimize doses of coal tar and UVR exposure in psoriatic patients in whom GT was applied. PMID:27188524

  10. Crystal structure of (1S,3R,8R,9R)-2,2-di­chloro-3,7,7-tri­methyl-10-methylenetri­cyclo­[6.4.0.01,3]dodecan-9-ol

    PubMed Central

    Benzalim, Ahmed; Auhmani, Aziz; Bimoussa, Abdoullah; Ait Itto, My Youssef; Daran, Jean-Claude; Auhmani, Abdelwahed

    2016-01-01

    The title compound, C16H24Cl2O, was synthesized by treating (1S,3R,8S,9R,10S)-2,2-di­chloro-3,7,7,10-tetra­methyl-9,10-ep­oxy­tri­cyclo­[6.4.0.01,3]dodecane with a concentrated solution of hydro­bromic acid. It is built up from three fused rings: a cyclo­heptane ring, a cyclo­hexyl ring bearing alkene and hy­droxy substituents, and a cyclo­propane ring bearing two chlorine atoms. The asymmetric unit contains two mol­ecules linked by an O—H⋯O hydrogen bond. In the crystal, further O—H⋯O hydrogen bonds build up an R 4 4(8) cyclic tetra­mer. One of the mol­ecules presents disorder that affects the seven-membered ring. In both mol­ecules, the six-membered rings display a chair conformation, whereas the seven-membered rings display conformations inter­mediate between boat and twist-boat for the non-disordered mol­ecule and either a chair or boat and twist-boat for the disordered mol­ecule owing to the disorder. The absolute configuration for both mol­ecules is 1S,3R,8R,9R and was deduced from the chemical pathway and further confirmed by the X-ray structural analysis. PMID:27536404

  11. Gel-assisted crystallization of [Ir4(IMe)7(CO)H10](2+) and [Ir4(IMe)8H9](3+) clusters derived from catalytic glycerol dehydrogenation.

    PubMed

    Sharninghausen, Liam S; Mercado, Brandon Q; Crabtree, Robert H; Balcells, David; Campos, Jesús

    2015-11-14

    The two title clusters were formed during iridium-catalyzed glycerol dehydrogenation and display a remarkably high NHC content. They were crystallized in either agarose or polyethylene oxide gel matrices, while more conventional crystallization techniques proved unsuccessful. Cluster [Ir4(IMe)8H9](3+), with a net charge of +3, was only crystallizable with a polyoxometalate Keggin trianion. The crystal packing of this intercluster compound is discussed. Computational studies position the iridium hydrides and provide insights into the bonding. PMID:26435314

  12. 45 CFR 5.69 - Exemptions 8 and 9: Records on financial institutions; records on wells.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Exemptions 8 and 9: Records on financial institutions; records on wells. 5.69 Section 5.69 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION FREEDOM OF INFORMATION REGULATIONS Reasons for Withholding Some Records § 5.69 Exemptions 8 and 9: Records on...

  13. Studies of the degradation mechanism of organic light-emitting diodes based on tris(8-quinolinolate)aluminum Alq and 2-tert-butyl-9,10-di(2-naphthyl)anthracene TBADN

    NASA Astrophysics Data System (ADS)

    Jarikov, Viktor V.; Kondakov, Denis Y.

    2009-02-01

    Previously, radical cation of tris(8-quinolinolate)aluminum (Alq•+) has been associated with the instability of Alq films subjected to holes-only electrical current. Yet, the questions remain (i) whether Alq•+ is the primary source of the intrinsic degradation of bipolar organic light-emitting diodes (OLEDs) based on Alq, (ii) whether Alq•+ reactions result in deep charge traps in holes-only devices as found in bipolar counterparts, and (iii) whether radical cations can be a common source of degradation of OLEDs irrespective of materials. With regards to generality of hole-current-related degradation, it is interesting to examine the behavior of 9,10-diarylanthracenes (DAAs)—the practically important class of blue-fluorescing light-emitting-layer hosts. These questions prompted our comparative study of the effects of unipolar currents in Alq and 2-t-butyl-9,10-di(2-naphthyl)anthracene (TBADN), which was chosen as a representative material of the DAA class. First, we identified device structures allowing for rigorous and stable unipolar conduction. Interestingly, even in pristine holes-only devices, our voltammetric measurements indicated that Alq contains a substantial density of deep hole traps (far deeper than what can be explained by energetic disorder), which can be charged by passing holes-only current and seemingly discharged by exposure to white light. As for aged holes-only Alq devices, they exhibited symptoms qualitatively matching those of aged bipolar Alq devices, viz., photoluminescence (PL) loss, transition voltage (V0) rise, and drive voltage (Vd) rise. Notably, PL and V0 are linearly correlated in both holes-only and bipolar devices, which reinforces the supposed link between Alq•+ and the degradation in both types of devices. Yet, there are indications the Alq•+ instability may not be the only degradation pathway in bipolar devices. Even though our observations for holes-only Alq devices agree qualitatively with previously reported ones

  14. 36 CFR 9.8 - Use of water.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Use of water. 9.8 Section 9.8 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR MINERALS... reserved water right of the United States and can demonstrate that the exercise of that State water...

  15. 36 CFR 9.8 - Use of water.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Use of water. 9.8 Section 9.8 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR MINERALS... reserved water right of the United States and can demonstrate that the exercise of that State water...

  16. 36 CFR 9.8 - Use of water.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Use of water. 9.8 Section 9.8 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR MINERALS... reserved water right of the United States and can demonstrate that the exercise of that State water...

  17. 36 CFR 9.8 - Use of water.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Use of water. 9.8 Section 9.8 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR MINERALS... reserved water right of the United States and can demonstrate that the exercise of that State water...

  18. 3. KONGENSGADE (FRONT) ELEVATIONS OF KONGENSGADE 8 AND 9 (LEFT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. KONGENSGADE (FRONT) ELEVATIONS OF KONGENSGADE 8 AND 9 (LEFT TO RIGHT) (see photograph VI-50-1 for plans of Kongensgade 8 & 9) - King Street Area Study, Kongensgade 5-18, 36, 37B, 51-58 (Houses), 5-18, 36-37B, 51-58 King Street, Frederiksted, St. Croix, VI

  19. 8 CFR 316.6-316.9 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false 316.6-316.9 Section 316.6-316.9 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY NATIONALITY REGULATIONS GENERAL REQUIREMENTS FOR NATURALIZATION §§ 316.6-316.9...

  20. 8 CFR 337.9 - Effective date of naturalization.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Effective date of naturalization. 337.9 Section 337.9 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY NATIONALITY REGULATIONS OATH OF ALLEGIANCE § 337.9 Effective date of naturalization. (a) An applicant for naturalization shall be deemed...

  1. 8 CFR 337.9 - Effective date of naturalization.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Effective date of naturalization. 337.9 Section 337.9 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY NATIONALITY REGULATIONS OATH OF ALLEGIANCE § 337.9 Effective date of naturalization. (a) An applicant for naturalization shall be deemed...

  2. 8 CFR 316.6-316.9 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false 316.6-316.9 Section 316.6-316.9 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY NATIONALITY REGULATIONS GENERAL REQUIREMENTS FOR NATURALIZATION §§ 316.6-316.9...

  3. 8 CFR 337.9 - Effective date of naturalization.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Effective date of naturalization. 337.9 Section 337.9 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY NATIONALITY REGULATIONS OATH OF ALLEGIANCE § 337.9 Effective date of naturalization. (a) An applicant for naturalization shall be deemed...

  4. 8 CFR 316.7-316.9 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false 316.7-316.9 Section 316.7-316.9 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY NATIONALITY REGULATIONS GENERAL REQUIREMENTS FOR NATURALIZATION §§ 316.7-316.9...

  5. 8 CFR 337.9 - Effective date of naturalization.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Effective date of naturalization. 337.9 Section 337.9 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY NATIONALITY REGULATIONS OATH OF ALLEGIANCE § 337.9 Effective date of naturalization. (a) An applicant for naturalization shall be deemed...

  6. 8 CFR 337.9 - Effective date of naturalization.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Effective date of naturalization. 337.9 Section 337.9 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY NATIONALITY REGULATIONS OATH OF ALLEGIANCE § 337.9 Effective date of naturalization. (a) An applicant for naturalization shall be deemed...

  7. 8 CFR 316.7-316.9 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false 316.7-316.9 Section 316.7-316.9 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY NATIONALITY REGULATIONS GENERAL REQUIREMENTS FOR NATURALIZATION §§ 316.7-316.9...

  8. 8 CFR 316.7-316.9 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false 316.7-316.9 Section 316.7-316.9 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY NATIONALITY REGULATIONS GENERAL REQUIREMENTS FOR NATURALIZATION §§ 316.7-316.9...

  9. Smad8/9 Is Regulated Through the BMP Pathway.

    PubMed

    Katakawa, Yuko; Funaba, Masayuki; Murakami, Masaru

    2016-08-01

    Members of the transforming growth factor-β (TGF-β) family function through Smad-dependent and Smad-independent pathways. The Smad-dependent pathway is stimulated through the phosphorylation of receptor-regulated Smad (R-Smad) and inhibited through the dephosphorylation of R-Smad or the gene induction of inhibitory Smad (I-Smad). Little information is available on the regulation of R-Smad gene expression. BMP4 potentiated the up-regulation of Smad8/9 expression in C2C12, H9c2, 3T3-L1, HepG2, B16, and primary fibroblasts. BMP4-induced Smad8/9 expression was cycloheximide-insensitive and LDN-193189-sensitive, suggesting a direct event mediated through BMP type I receptors. BMP4 transcriptionally stimulated the Smad8/9 gene, and BMP-responsive elements (BREs) spanning nt -121 to nt -44 are involved in the up-regulation of Smad8/9 expression in response to BMP4. Phosphorylated Smad1/5/8/9 specifically bound to the BREs of Smad8/9 gene. The present study reveals that Smad8/9 is a unique R-Smad regulated through the BMP pathway at the mRNA level. J. Cell. Biochem. 117: 1788-1796, 2016. © 2016 Wiley Periodicals, Inc. PMID:26748560

  10. Purification of Drosophila ribosomal proteins. Isolation of proteins S8, S13, S14, S16, S19, S20/L24, S22/L26, S24, S25/S27, S26, S29, L4, L10/L11, L12, L13, L16, L18, L19, L27, 1, 7/8, 9, and 11.

    PubMed

    Chooi, W Y

    1980-07-22

    The proteins of Drosophila melanogaster embryonic ribosomes were separated into seven groups (A80 through G80) by stepwise elution from carboxymethylcellulose with lithium chloride at pH 6.5 by procedures previously described [Chooi, W. Y., Sabatini, L. M., MacKlin, M. D., & Fraser, W. (1980) Biochemistry 19, 1425-1433]. Three relatively acidic proteins, S14, S25/S27, and 7/8, have now been isolated from group A80 by ion-exchange chromatog raphy on carboxymethylcellulose eluted with a linear gradient of lithium chloride at pH 4.2. Fractions containing the relatively basic proteins (groups B80 through G80) were furher combined into a total of 24 "pools". The criterion for combination was the migration patterns in one-dimensional polyacrylamide gels containing sodium dodecyl sulfate (NaDodS04) of every fifth fraction from the carboxymethylcellulose column. Each pool contained between 1 and 12 major proteins. Proteins S8, S13, S16, S19, S20/L24, S22/L26, S24, S26, S29, L4, L10/L11, L12, L13, L16, L18, L19, L27, 1, 9, and 11 have now been isolated from selected pools by gel filtration through Sephadix G-100. The amount of each protein recovered from a starting amount of 1.8 g of total 80S proteins varied form 0.2 to 10.8 mg. Five proteins had no detectable contamination, and in each of the others the impurities were no greater than 9%. The amino acid composition of the individual purified proteins was determined. The molecular weights of the proteins were estimated by polyacrylamide gel electrophoresis in NaDodSO4.

  11. 46 CFR 113.10-9 - Power supply.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Power supply. 113.10-9 Section 113.10-9 Shipping COAST... SYSTEMS AND EQUIPMENT Fire and Smoke Detecting and Alarm Systems § 113.10-9 Power supply. (a) General. There must be at least two sources of power for the electrical equipment of each fire detecting...

  12. 46 CFR 113.10-9 - Power supply.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Power supply. 113.10-9 Section 113.10-9 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING COMMUNICATION AND ALARM SYSTEMS AND EQUIPMENT Fire and Smoke Detecting and Alarm Systems § 113.10-9 Power supply. (a)...

  13. 46 CFR 113.10-9 - Power supply.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Power supply. 113.10-9 Section 113.10-9 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING COMMUNICATION AND ALARM SYSTEMS AND EQUIPMENT Fire and Smoke Detecting and Alarm Systems § 113.10-9 Power supply. (a)...

  14. 46 CFR 113.10-9 - Power supply.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Power supply. 113.10-9 Section 113.10-9 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING COMMUNICATION AND ALARM SYSTEMS AND EQUIPMENT Fire and Smoke Detecting and Alarm Systems § 113.10-9 Power supply. (a)...

  15. 46 CFR 113.10-9 - Power supply.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Power supply. 113.10-9 Section 113.10-9 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING COMMUNICATION AND ALARM SYSTEMS AND EQUIPMENT Fire and Smoke Detecting and Alarm Systems § 113.10-9 Power supply. (a)...

  16. 46 CFR 90.10-9 - Coast Guard District Commander.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Coast Guard District Commander. 90.10-9 Section 90.10-9 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS GENERAL PROVISIONS Definition of Terms Used in This Subchapter § 90.10-9 Coast Guard District Commander. This...

  17. 46 CFR 90.10-9 - Coast Guard District Commander.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Coast Guard District Commander. 90.10-9 Section 90.10-9 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS GENERAL PROVISIONS Definition of Terms Used in This Subchapter § 90.10-9 Coast Guard District Commander. This...

  18. 46 CFR 90.10-9 - Coast Guard District Commander.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Coast Guard District Commander. 90.10-9 Section 90.10-9 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS GENERAL PROVISIONS Definition of Terms Used in This Subchapter § 90.10-9 Coast Guard District Commander. This...

  19. 46 CFR 90.10-9 - Coast Guard District Commander.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Coast Guard District Commander. 90.10-9 Section 90.10-9 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS GENERAL PROVISIONS Definition of Terms Used in This Subchapter § 90.10-9 Coast Guard District Commander. This...

  20. 46 CFR 90.10-9 - Coast Guard District Commander.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Coast Guard District Commander. 90.10-9 Section 90.10-9 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS GENERAL PROVISIONS Definition of Terms Used in This Subchapter § 90.10-9 Coast Guard District Commander. This...

  1. 46 CFR 188.10-9 - Chemical storeroom.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Chemical storeroom. 188.10-9 Section 188.10-9 Shipping... PROVISIONS Definition of Terms Used in This Subchapter § 188.10-9 Chemical storeroom. This term refers to any compartment specifically constructed or modified for the stowage of chemical stores and so designated...

  2. 46 CFR 188.10-9 - Chemical storeroom.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Chemical storeroom. 188.10-9 Section 188.10-9 Shipping... PROVISIONS Definition of Terms Used in This Subchapter § 188.10-9 Chemical storeroom. This term refers to any compartment specifically constructed or modified for the stowage of chemical stores and so designated...

  3. 46 CFR 188.10-9 - Chemical storeroom.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Chemical storeroom. 188.10-9 Section 188.10-9 Shipping... PROVISIONS Definition of Terms Used in This Subchapter § 188.10-9 Chemical storeroom. This term refers to any compartment specifically constructed or modified for the stowage of chemical stores and so designated...

  4. 46 CFR 188.10-9 - Chemical storeroom.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Chemical storeroom. 188.10-9 Section 188.10-9 Shipping... PROVISIONS Definition of Terms Used in This Subchapter § 188.10-9 Chemical storeroom. This term refers to any compartment specifically constructed or modified for the stowage of chemical stores and so designated...

  5. 46 CFR 188.10-9 - Chemical storeroom.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Chemical storeroom. 188.10-9 Section 188.10-9 Shipping... PROVISIONS Definition of Terms Used in This Subchapter § 188.10-9 Chemical storeroom. This term refers to any compartment specifically constructed or modified for the stowage of chemical stores and so designated...

  6. 9 CFR 112.8 - For export only.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false For export only. 112.8 Section 112.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS PACKAGING AND LABELING § 112.8 For...

  7. 9 CFR 112.8 - For export only.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false For export only. 112.8 Section 112.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS PACKAGING AND LABELING § 112.8 For...

  8. 9 CFR 112.8 - For export only.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false For export only. 112.8 Section 112.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS PACKAGING AND LABELING § 112.8 For...

  9. 9 CFR 56.8 - Conditions for payment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Conditions for payment. 56.8 Section 56.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE COOPERATIVE CONTROL AND ERADICATION OF LIVESTOCK OR POULTRY DISEASES CONTROL OF H5/H7 LOW PATHOGENIC AVIAN INFLUENZA § 56.8 Conditions for...

  10. 9 CFR 166.8 - Vehicles used to transport garbage.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Vehicles used to transport garbage. 166.8 Section 166.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE SWINE HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.8...

  11. 9 CFR 166.8 - Vehicles used to transport garbage.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Vehicles used to transport garbage. 166.8 Section 166.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE SWINE HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.8...

  12. 9 CFR 112.8 - For export only.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false For export only. 112.8 Section 112.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS PACKAGING AND LABELING § 112.8 For...

  13. 9 CFR 3.8 - Exercise for dogs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Exercise for dogs. 3.8 Section 3.8... Cats 1 Animal Health and Husbandry Standards § 3.8 Exercise for dogs. Dealers, exhibitors, and research... exercise. In addition, the plan must be approved by the attending veterinarian. The plan must...

  14. 9 CFR 3.8 - Exercise for dogs.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Exercise for dogs. 3.8 Section 3.8... Cats 1 Animal Health and Husbandry Standards § 3.8 Exercise for dogs. Dealers, exhibitors, and research... exercise. In addition, the plan must be approved by the attending veterinarian. The plan must...

  15. 9 CFR 112.8 - For export only.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false For export only. 112.8 Section 112.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS PACKAGING AND LABELING § 112.8 For...

  16. 9 CFR 166.8 - Vehicles used to transport garbage.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Vehicles used to transport garbage. 166.8 Section 166.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE SWINE HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.8...

  17. 9 CFR 351.8 - Charges for surveys of plants.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Charges for surveys of plants. 351.8 Section 351.8 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... INSPECTION AND CERTIFICATION CERTIFICATION OF TECHNICAL ANIMAL FATS FOR EXPORT Fees § 351.8 Charges...

  18. 9 CFR 3.8 - Exercise for dogs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Exercise for dogs. 3.8 Section 3.8... WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Dogs and Cats 1 Animal Health and Husbandry Standards § 3.8 Exercise for dogs. Dealers, exhibitors, and...

  19. 9 CFR 149.8 - Program fees and charges.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Program fees and charges. 149.8 Section 149.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT VOLUNTARY TRICHINAE CERTIFICATION PROGRAM § 149.8 Program fees and...

  20. 9 CFR 149.8 - Program fees and charges.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Program fees and charges. 149.8 Section 149.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT VOLUNTARY TRICHINAE CERTIFICATION PROGRAM § 149.8 Program fees and...

  1. 9 CFR 149.8 - Program fees and charges.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Program fees and charges. 149.8 Section 149.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT VOLUNTARY TRICHINAE CERTIFICATION PROGRAM § 149.8 Program fees and...

  2. 9 CFR 149.8 - Program fees and charges.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Program fees and charges. 149.8 Section 149.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT VOLUNTARY TRICHINAE CERTIFICATION PROGRAM § 149.8 Program fees and...

  3. 9 CFR 166.8 - Vehicles used to transport garbage.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Vehicles used to transport garbage. 166.8 Section 166.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE SWINE HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.8 Vehicles used to transport garbage. Vehicles used by...

  4. 9 CFR 166.8 - Vehicles used to transport garbage.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Vehicles used to transport garbage. 166.8 Section 166.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE SWINE HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.8 Vehicles used to transport garbage. Vehicles used by...

  5. 9 CFR 146.8 - Terminology and classification; slaughter plants.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Terminology and classification; slaughter plants. 146.8 Section 146.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... General Provisions § 146.8 Terminology and classification; slaughter plants. Participating...

  6. 10 CFR 9.35 - Duplication fees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... § 9.21 at the NRC Public Document Room (PDR), One White Flint North, 11555 Rockville Pike, Room O-1F23... at One White Flint North, 11555 Rockville Pike (first floor), Rockville, Maryland. (1) Sizes up to...

  7. 10 CFR 9.35 - Duplication fees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... § 9.21 at the NRC Public Document Room (PDR), One White Flint North, 11555 Rockville Pike, Room O-1F23... at One White Flint North, 11555 Rockville Pike (first floor), Rockville, Maryland. (1) Sizes up to...

  8. A new 9,10-dihydrophenanthrene from Dendrobium moniliforme.

    PubMed

    Zhao, Ningdong; Yang, Guangyu; Zhang, Yan; Chen, Lijun; Chen, Yegao

    2016-01-01

    A new 9,10-dihydrophenanthrene,1,5-dihydroxy-3,4,7-trimethoxy-9,10-dihydrophenanthrene (1) was isolated and identified from the whole plants of Dendrobium moniliforme, as well as 24 known compounds including hircinol (2), (2R*,3S*)-3-hydroxymethyl-9-methoxy-2-(4'-hydroxy-3',5'-dimethoxyphenyl)-2,3,6,7-tetrahydro-phenanthro[4,3-b]furan-5,11-diol (3), diospyrosin (4), aloifol I (5), moscatilin (6), 3,4'-dihydroxy-3',4,5-trimethoxybibenzyl (7), gigantol (8), 3,3'-dihydroxy-4,5-dimethoxybibenzyl (9), longicornuol A (10), N-trans-cinnamoyltyramine (11), paprazine (12), N-trans-feruloyl 3'-O-methyldopamine (13), moupinamide (14), dihydroconiferyl dihydro-p-coumarate (15), dihydrosinapyl dihydro-p-coumarate (16), 3-isopropyl-5-acetoxycyclohexene-2-one-1 (17), p-hydroxybenzaldehyde (18), vanillin (19), p-hydroxyphenylpropionic acid (20), vanillic acid (21), protocatechuic acid (22), (+)-syringaresinol (23), β-sitosterol (24) and daucosterol (25). Compounds 3, 4, 13, 16, 17 and 20 were isolated from the Dendrobium genus for the first time, and compounds 2, 5, 7, 9-12, 14, 15, 18, 21 and 22 were originally obtained from D. moniliforme.

  9. 10 CFR 605.9 - Application requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... make informed preaward determinations under 10 CFR part 600. (5) Any preaward assurances required pursuant to 10 CFR parts 600 and 605. (c) Applications for a renewal award must be submitted in an original... Order 12372 and 10 CFR part 1005. Anyone planning to submit such applications should contact ER...

  10. 8. Historic American Buildings Survey Alex Bush, Photographer, November 9, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Historic American Buildings Survey Alex Bush, Photographer, November 9, 1936 NORTH WEST CORNER OF ROOM ON SECOND FLOOR SHOWING WINDOW AND MANTEL - Strawberry Hill Plantation, U.S. Route 43, Forkland, Greene County, AL

  11. 9. Historic American Buildings Survey Alex Bush, Photographer, January 8, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Historic American Buildings Survey Alex Bush, Photographer, January 8, 1937 LOOKING NORTH EAST IN COURT ROOM - Wilcox County Courthouse, Broad, Claiborne, Court & Water Streets, Camden, Wilcox County, AL

  12. 8. Historic American Buildings Survey Alexander Piaget, Photographer, April 9, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Historic American Buildings Survey Alexander Piaget, Photographer, April 9, 1934 INTERIOR VIEW LOOKING UP INTO THE DOME - Old St. Louis Courthouse, Fourth to Broadway, Market to Chestnut Streets, Saint Louis, Independent City, MO

  13. 9. Historic American Buildings Survey Alex Bush, Photographer, December 8, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Historic American Buildings Survey Alex Bush, Photographer, December 8, 1936 MANTEL ON WEST WALL OF BED ROOM IN L PART OF HOUSE - John H. Sherard House, State Road 28, Livingston, Sumter County, AL

  14. 10 CFR 602.8 - Application requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... necessary for clarification or make informed pre-award determinations under 10 CFR part 600. (5) Any pre-award assurances required pursuant to 10 CFR parts 600 and 602. (c) Applications for a renewal award... all information and documentation required by statute, this part, 10 CFR part 600, or the notice...

  15. The {sup 9}Be({sup 8}Li,{sup 9}Be){sup 8}Li elastic-transfer reaction

    SciTech Connect

    Camargo, O.; Guimaraes, V.; Lichtenthaeler, R.; Scarduelli, V.; Kolata, J. J.; Bertulani, C. A.; Amro, H.; Becchetti, F. D.; Jiang Hao; Aguilera, E. F.; Lizcano, D.; Martinez-Quiroz, E.; Garcia, H.

    2008-09-15

    Angular distributions for the {sup 9}Be({sup 8}Li,{sup 9}Be){sup 8}Li elastic-transfer reaction have been measured with a 27-MeV {sup 8}Li radioactive nuclear beam. Spectroscopic factors for the <{sup 9}Be|{sup 8}Li+p> bound system were obtained from the comparison between the experimental differential cross sections and finite-range distorted-wave Born approximation calculations made with the code FRESCO. The spectroscopic factors so obtained are compared with shell-model calculations and other experimental values. Using the present value for the spectroscopic factors, cross sections and reaction rates for the {sup 8}Li(p,{gamma}){sup 9}Be direct proton-capture reaction of astrophysical interest were calculated in the framework of the potential model.

  16. Crystal structure of (1S,3R,8R,9R,10S)-2,4,6-tris­(2,2-di­chloro-3,7,7,10-tetra­methyl­tri­cyclo­[6.4.0.01,3]dodec-9-yl)cyclo­triboroxane

    PubMed Central

    Benharref, Ahmed; El Ammari, Lahcen; Saadi, Mohamed; Mazoir, Noureddine; Berraho, Moha

    2015-01-01

    The title compound, C48H75B3Cl6O3, was synthesized in two steps from β-himachalene (3,5,5,9-tetra­methyl-2,4a,5,6,7,8-hexa­hydro-1H-benzo­cyclo­hept­ene), which was isolated from the essential oil of the Atlas cedar (Cedrus Atlantica). The mol­ecule consists of an almost planar cyclo­triboroxane ring [maximum deviation = 0.036 (2) Å] linked to three identical fused ring systems with different conformations. Each of the three attached ring systems is built up from a seven-membered ring to which a six- and a three-membered ring are fused. The three six-membered rings have a twist-boat conformation, whereas the seven-membered rings display boat, chair and twist-boat conformations. The dihedral angles between the central boroxane ring and the mean planes of the attached six-membered rings are 63.67 (18), 54.89 (2) and 56.57 (19)°. The crystal packing is governed only by van der Waals inter­actions. PMID:26396761

  17. 8 CFR 215.9 - Temporary Worker Visa Exit Program.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Temporary Worker Visa Exit Program. 215.9... ALIENS DEPARTING FROM THE UNITED STATES § 215.9 Temporary Worker Visa Exit Program. An alien admitted on certain temporary worker visas at a port of entry participating in the Temporary Worker Visa Exit...

  18. 8 CFR 207.9 - Termination of refugee status.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Termination of refugee status. 207.9... REFUGEES § 207.9 Termination of refugee status. The refugee status of any alien (and of the spouse or child... district director in whose district the alien is found if the alien was not a refugee within the meaning...

  19. 8 CFR 207.9 - Termination of refugee status.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Termination of refugee status. 207.9... REFUGEES § 207.9 Termination of refugee status. The refugee status of any alien (and of the spouse or child... district director in whose district the alien is found if the alien was not a refugee within the meaning...

  20. 14. VIEW LOOKING UPSTREAM BETWEEN BUTTRESSES 8 AND 9, AT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. VIEW LOOKING UPSTREAM BETWEEN BUTTRESSES 8 AND 9, AT COMPLETED OUTLET CHANNEL PAVING. NOTE SLIDE GATE OUTLET STRUCTURE AT UPSTREAM END OF PAVING, AND NEEDLE VALVE OUTLETS AT RIGHT. September 9, 1938 - Bartlett Dam, Verde River, Phoenix, Maricopa County, AZ

  1. Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease.

    PubMed

    Maalej, Emna; Chabchoub, Fakher; Oset-Gasque, María Jesús; Esquivias-Pérez, Mario; González, María P; Monjas, Leticia; Pérez, Concepción; de los Ríos, Cristóbal; Rodríguez-Franco, María Isabel; Iriepa, Isabel; Moraleda, Ignacio; Chioua, Mourad; Romero, Alejandro; Marco-Contelles, José; Samadi, Abdelouahid

    2012-08-01

    The synthesis, pharmacological analysis and molecular modeling of the readily available racemic tacrine analogs 21-30, bearing the 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amine heterocyclic ring system (II), prepared by Friedländer reaction of 2-amino-4-aryl-4H-benzo[h]chromene-3-carbonitriles (11-20) with cyclohexanone, are described in this paper. Molecules 21-30 are potent and selective inhibitors of hAChE, in the low micromolar range, one of the most potent inhibitors, 4-(8-amino-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-7-yl)-2-methoxyphenol (25), showing a IC(50) (hAChE) = 0.33 ± 0.04 μM. Kinetic studies of compound 25 proved that this compound is a mixed type inhibitor for EeAChE (K(i) = 81 nM). Accordingly, molecular modeling of inhibitor 25 showed that both enantiomers have two major predicted binding modes at the active and at the peripheral anionic sites of AChE. Inhibitor 25 has an excellent antioxidant profile as determined in the ORAC experiment (1.47 ± 0.10 Trolox equiv). Inhibitors 26-28 and 30 are permeable to BBB as determined in the PAMPA assay. Compared to tacrine, selected compounds 26-28 and 30 showed less hepatic toxicity in HepG2 cells. Moreover, cell viability-related studies in cortical neurons in primary cultures show that compounds 26-28 and 30 (0.1-50 μM) have significant neuroprotective effects against mitochondrial chain blockers-induced cell death, and, unlike tacrine, are not neurotoxic at concentrations lower than 50 μM. It is worth highlighting that compound 27 has the best neuroprotective properties out of all assayed compounds and shows no neurotoxicity. To sum up, these tacrine analogs can be considered as attractive multipotent therapeutic molecules on pharmacological receptors playing key roles in the progress of Alzheimer's disease. PMID:22795665

  2. Determination of the stereoisomers in aqueous medium and serum and validation studies of racemic aminoalkanol derivatives of 1,7-dimethyl-8,9-diphenyl-4-azatricyclo[5.2.1.0(2,6) ]dec-8-ene-3,5,10-trione, potential new anticancer drugs, by capillary electrophoresis.

    PubMed

    Grodner, Błażej; Łukaszkiewicz, Jacek; Napiórkowska, Mariola

    2016-08-01

    A new method for the determination of the stereoisomers, in aqueous medium and serum, of the racemic aminoalkanol derivatives I and II of 1,7-dimethyl-8,9-diphenyl-4-azatricyclo[5.2.1.0(2,6) ]dec-8-ene-3,5,10-trione, which were found in earlier studies to be potential anticancer drugs, was developed and validated. The optimized conditions included 25 mM phosphate buffer adjusted to pH 2.5, containing γ-cyclodextrin at a concentration of 5% m/v, as background electrolyte, an applied voltage of +10 kV, and a temperature of 25°C. Separations were carried out using a fused-silica capillary. The developed method of determining the enantiomers of compounds I(S), I(R) and II(S), II(R) was characterized by the following parameters: a detection time within 10.8 min, a detection limit in the range of 141.2-141.7 ng/mL using the UV absorption detection at 200 nm. Good linearity (R(2) = 0.9989-0.9998) was achieved within the range of concentrations studied. A very good extraction yield of 95.4-99.7% was achieved, and recoveries were carried out from both aqueous solutions and matrix serum. The repeatability of the method for peak areas with an accuracy of the determined concentrations of the analytes in the range of 1.43-1.89%, and limits of quantitation in the range of 432.4-436.3 ng/mL were achieved. PMID:27421088

  3. 10 CFR 9.103 - General provisions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... regulations (10 CFR part 2) except as the Commission may direct. Members of the public attending open... reasonable space and adequate visibility and acoustics, for public observation. No additional right...

  4. 10 CFR 9.103 - General provisions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... regulations (10 CFR part 2) except as the Commission may direct. Members of the public attending open... reasonable space and adequate visibility and acoustics, for public observation. No additional right...

  5. 10 CFR 9.103 - General provisions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... regulations (10 CFR part 2) except as the Commission may direct. Members of the public attending open... reasonable space and adequate visibility and acoustics, for public observation. No additional right...

  6. 10 CFR 9.103 - General provisions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... regulations (10 CFR part 2) except as the Commission may direct. Members of the public attending open... reasonable space and adequate visibility and acoustics, for public observation. No additional right...

  7. 10 CFR 9.103 - General provisions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... regulations (10 CFR part 2) except as the Commission may direct. Members of the public attending open... reasonable space and adequate visibility and acoustics, for public observation. No additional right...

  8. 9 CFR 53.8 - Presentation of claims.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Presentation of claims. 53.8 Section 53.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF... burial, burning, or other disposition of animals; (3) The value of material destroyed; and (4)...

  9. 9 CFR 53.8 - Presentation of claims.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Presentation of claims. 53.8 Section 53.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF... burial, burning, or other disposition of animals; (3) The value of material destroyed; and (4)...

  10. 9 CFR 314.8 - Dead animal carcasses.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Dead animal carcasses. 314.8 Section 314.8 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... Dead animal carcasses. (a) With the exception of dead livestock which have died en route and...

  11. 9 CFR 314.8 - Dead animal carcasses.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Dead animal carcasses. 314.8 Section 314.8 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... Dead animal carcasses. (a) With the exception of dead livestock which have died en route and...

  12. 9 CFR 314.8 - Dead animal carcasses.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Dead animal carcasses. 314.8 Section 314.8 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... Dead animal carcasses. (a) With the exception of dead livestock which have died en route and...

  13. 9 CFR 314.8 - Dead animal carcasses.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Dead animal carcasses. 314.8 Section 314.8 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... Dead animal carcasses. (a) With the exception of dead livestock which have died en route and...

  14. 9 CFR 314.8 - Dead animal carcasses.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Dead animal carcasses. 314.8 Section 314.8 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... Dead animal carcasses. (a) With the exception of dead livestock which have died en route and...

  15. Mathematics 8 and 9: Teacher Resource Manual. Curriculum, Interim 1989.

    ERIC Educational Resources Information Center

    Dawson, Jon, Ed.

    This teacher resource manual has been developed to assist classroom teachers in implementing the Integrated Occupational Mathematics program for grades 8 and 9. The first chapter of this manual gives an introduction including resources and scope/sequence. The next two chapters describe the overviews and instructional strategies of the grade 8 and…

  16. 9 CFR 56.8 - Conditions for payment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Conditions for payment. 56.8 Section 56.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE COOPERATIVE CONTROL AND ERADICATION OF LIVESTOCK OR POULTRY DISEASES CONTROL OF H5/H7...

  17. 9 CFR 114.8 - Outline of Production required.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Outline of Production required. 114.8 Section 114.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF... Animal and Plant Health Inspection Service for each licensed biological product or for each...

  18. 9 CFR 53.8 - Presentation of claims.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Presentation of claims. 53.8 Section 53.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE COOPERATIVE CONTROL AND ERADICATION OF LIVESTOCK OR POULTRY DISEASES FOOT-AND-MOUTH...

  19. 9 CFR 53.8 - Presentation of claims.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Presentation of claims. 53.8 Section 53.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE COOPERATIVE CONTROL AND ERADICATION OF LIVESTOCK OR POULTRY DISEASES FOOT-AND-MOUTH...

  20. 9 CFR 53.8 - Presentation of claims.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Presentation of claims. 53.8 Section 53.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE COOPERATIVE CONTROL AND ERADICATION OF LIVESTOCK OR POULTRY DISEASES FOOT-AND-MOUTH...