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Sample records for 8 9 10

  1. 10 CFR 9.8 - Information collection requirements: OMB approval.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Information collection requirements: OMB approval. 9.8 Section 9.8 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS § 9.8 Information collection requirements: OMB approval. (a) The Nuclear Regulatory Commission has submitted the information...

  2. 10 CFR 9.8 - Information collection requirements: OMB approval.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Information collection requirements: OMB approval. 9.8 Section 9.8 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS § 9.8 Information collection requirements: OMB approval. (a) The Nuclear Regulatory Commission has submitted the information...

  3. 10 CFR 9.8 - Information collection requirements: OMB approval.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Information collection requirements: OMB approval. 9.8 Section 9.8 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS § 9.8 Information collection requirements: OMB approval. (a) The Nuclear Regulatory Commission has submitted the information...

  4. 10 CFR 9.8 - Information collection requirements: OMB approval.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Information collection requirements: OMB approval. 9.8 Section 9.8 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS § 9.8 Information collection requirements: OMB approval. (a) The Nuclear Regulatory Commission has submitted the information...

  5. 10 CFR 9.8 - Information collection requirements: OMB approval.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Information collection requirements: OMB approval. 9.8 Section 9.8 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS § 9.8 Information collection requirements: OMB approval. (a) The Nuclear Regulatory Commission has submitted the information...

  6. 9. 8' X 10' Enlargement from 4' x 5' negative ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. 8' X 10' Enlargement from 4' x 5' negative Kevin Kriesel-Coons, Photographer PUMPS AFTER REMOVAL FROM PUMPHOUSE BEFORE EXCAVATION OF POND AREA IN 1989. PHOTOGRAPHED LYING ON GROUND NEAR CROSSCUT STEAM PLANT BUILDING. - Crosscut Steam Plant, Indian Bend Pond & Pump Ditch, North side Salt River near Mill Avenue & Washington Street, Tempe, Maricopa County, AZ

  7. Synthesis and biological activity of new 1,8-diaza-2,9,10-anthracenetrione derivatives.

    PubMed

    Gesto, C; de la Cuesta, E; Avendaño, C; Emling, F

    1992-08-01

    Diels-Alder heterocycloaddition reactions of 2,5,8-quinolinetriones and 1-azadienes afford 1,8-diaza-2,9,10-anthracenetriones, which are simple analogues of the antitumoral antibiotic diazaquinomicin A. Cytotoxicity in this series and antitumor activity of the lead compound, 6-methyl-1,8-diaza-2,9,10-anthracenetrione, are reported.

  8. Phosphine-boranes as bidentate ligands: formation of [8,8-eta(2)-(eta(2)-(BH(3)).dppm)-nido-8,7-RhSB(9)H(10)] and [9,9-eta(2)-(eta(2)-(BH(3)).dppm)-nido-9,7,8-RhC(2)B(8)H(11)] from [8,8-(eta(2)-dppm)-8-(eta(1)-dppm)-nido-8,7-RhSB(9)H(10)] and [9,9-(eta(2)-dppm)-9-(eta(1)-dppm)-nido-9,7,8-RhC(2)B(8)H(11)], respectively.

    PubMed

    Volkov, Oleg; Macías, Ramón; Rath, Nigam P; Barton, Lawrence

    2002-11-04

    The two clusters [8,8-(eta(2)-dppm)-8-(eta(1)-dppm)-nido-8,7-RhSB(9)H(10)] (1) and [9,9-(eta(2)-dppm)-9-(eta(1)-dppm)-nido-9,7,8-RhC(2)B(8)H(11)] (2) (dppm = PPh(2)CH(2)PPh(2)), both of which contain pendant PPh(2) groups, react with BH(3).thf to afford the species [8,8-eta(2)-(eta(2)-(BH(3)).dppm)-nido-8,7-RhSB(9)H(10)] (3) and [9,9-eta(2)-(eta(2)-(BH(3)).dppm))-nido-9,7,8-RhC(2)B(8)H(11)] (4), respectively. These two species are very similar in that they both contain the bidentate ligand [(BH(3)).dppm], which coordinates to the Rh center via a PPh(2) group and also via a eta(2)-BH(3) group. Thus, the B atom in the BH(3) group is four-coordinate, bonded to Rh by two bridging hydrogen atoms, to a terminal H atom, and to a PPh(2) group. At room temperature, the BH(3) group is fluxional; the two bridging H atoms and the terminal H atom are equivalent on the NMR time scale. The motion is arrested at low temperature with DeltaG++ = ca. 37 and 42 kJ mol(-1), respectively, for 3 and 4. Both species are characterized completely by NMR and mass spectral measurements as well as by elemental analysis and single-crystal structure determinations.

  9. Structure of the toxaphene compound 2,5-endo,6-exo,8,9,9,10,10-octachlorobornene-2: a temperature-dependent formation of two rotamers.

    PubMed

    Parlar, Harun; Burhenne, Jürgen; Coelhan, Mehmet; Vetter, Walter

    2005-03-15

    The irradiation of 2,2,3-exo,5-endo,6-exo,8,9,9,10,10-decachlorobornane in n-hexane at 254 nm leads to a spontaneous Cl2 elimination as the major reaction pathway. This results finally in the main product 2,5-endo,6-exo,8,9,9,10,10-octachlorobornene-2, of which the structure could be elucidated with the help of X-ray, 1H and 13C NMR, IR, and MS. Temperature-dependent 1H NMR spectroscopic investigations have shown that the -CHCl2 groups located at C1 and C7 are able to rotate slowly under normal circumstances. If such measurements, however, are exerted at low temperatures (-10 to -60 degrees C), so can be seen that two rotamers are formed due to the hindrance of the free rotation about the bonds C1-C10, C7-C8, and C7-C9, which for the first time could be revealed for a toxaphene compound. Furthermore, as all 1H NMR chlorobornane spectra known so far show only sharp and clear signals, it can be assumed that chlorobornane compounds as main toxaphene components have fixed bonds, which requires to indicate chlorine atoms within the tentacles such as "a", "b", and "c" for characterizing the correct position. Those fixed tentacles are probably the reason that many toxaphene congeners remain very stable in environmental compartments, and particularly the biotic and abiotic transformation may strongly be hindered by the inflexibility of the tentacles.

  10. 40 CFR 721.10024 - 10H-Phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false 10H-Phenothiazine, ar-(C9-rich C8-10... New Uses for Specific Chemical Substances § 721.10024 10H-Phenothiazine, ar-(C9-rich C8-10-branched... substance identified as 10H-phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs (PMN P-01-771; CAS...

  11. 40 CFR 721.10024 - 10H-Phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false 10H-Phenothiazine, ar-(C9-rich C8-10... New Uses for Specific Chemical Substances § 721.10024 10H-Phenothiazine, ar-(C9-rich C8-10-branched... substance identified as 10H-phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs (PMN P-01-771; CAS...

  12. 40 CFR 721.10024 - 10H-Phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false 10H-Phenothiazine, ar-(C9-rich C8-10... New Uses for Specific Chemical Substances § 721.10024 10H-Phenothiazine, ar-(C9-rich C8-10-branched... substance identified as 10H-phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs (PMN P-01-771; CAS...

  13. 40 CFR 721.10024 - 10H-Phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false 10H-Phenothiazine, ar-(C9-rich C8-10... New Uses for Specific Chemical Substances § 721.10024 10H-Phenothiazine, ar-(C9-rich C8-10-branched... substance identified as 10H-phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs (PMN P-01-771; CAS...

  14. 40 CFR 721.10024 - 10H-Phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false 10H-Phenothiazine, ar-(C9-rich C8-10... New Uses for Specific Chemical Substances § 721.10024 10H-Phenothiazine, ar-(C9-rich C8-10-branched... substance identified as 10H-phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs (PMN P-01-771; CAS...

  15. The Implementation of Effective Teaching Practices in English Classroom for Grades 8th, 9th, and 10th.

    ERIC Educational Resources Information Center

    Al-Hilawani, Yasser A.; And Others

    This study explored teachers' behavior as related to effective teaching practices in 8th, 9th, and 10th grade English classrooms in Jordan. The study also examined some variables that could predict teachers' implementation of effective teaching practices and aimed at finding an estimate of the percentage of students in 8th, 9th, and 10th grades…

  16. 40 CFR 721.10025 - 10H-Phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false 10H-Phenothiazine, ar, arâ²-(C9-rich... Significant New Uses for Specific Chemical Substances § 721.10025 10H-Phenothiazine, ar, ar′-(C9-rich C8-10... chemical substances identified as 10H-phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  17. 40 CFR 721.10025 - 10H-Phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false 10H-Phenothiazine, ar, arâ²-(C9-rich... Significant New Uses for Specific Chemical Substances § 721.10025 10H-Phenothiazine, ar, ar′-(C9-rich C8-10... chemical substances identified as 10H-phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  18. 40 CFR 721.10025 - 10H-Phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false 10H-Phenothiazine, ar, arâ²-(C9-rich... Significant New Uses for Specific Chemical Substances § 721.10025 10H-Phenothiazine, ar, ar′-(C9-rich C8-10... chemical substances identified as 10H-phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  19. 40 CFR 721.10025 - 10H-Phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false 10H-Phenothiazine, ar, arâ²-(C9-rich... Significant New Uses for Specific Chemical Substances § 721.10025 10H-Phenothiazine, ar, ar′-(C9-rich C8-10... chemical substances identified as 10H-phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  20. 40 CFR 721.10025 - 10H-Phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false 10H-Phenothiazine, ar, arâ²-(C9-rich... Significant New Uses for Specific Chemical Substances § 721.10025 10H-Phenothiazine, ar, ar′-(C9-rich C8-10... chemical substances identified as 10H-phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  1. Antidiarrheal Thymol Derivatives from Ageratina glabrata. Structure and Absolute Configuration of 10-Benzoyloxy-8,9-epoxy-6-hydroxythymol Isobutyrate.

    PubMed

    Bustos-Brito, Celia; Vázquez-Heredia, Valeria J; Calzada, Fernando; Yépez-Mulia, Lilian; Calderón, José S; Hernández-Ortega, Simón; Esquivel, Baldomero; García-Hernández, Normand; Quijano, Leovigildo

    2016-09-12

    Chemical investigation of the leaves from Ageratina glabrata yielded four new thymol derivatives, namely: 10-benzoyloxy-8,9-dehydro-6-hydroxythymol isobutyrate (4), 10-benzoyloxy-8,9-dehydrothymol (5), 10-benzoyloxythymol (6) and 10-benzoyloxy-6,8-dihydroxy-9-isobutyryl-oxythymol (7). In addition, (8S)-10-benzoyloxy-8,9-epoxy-6-hydroxythymol isobutyrate (1), together with other two already known thymol derivatives identified as 10-benzoyloxy-8,9-epoxy-6-methoxythymol isobutyrate (2) and 10-benzoyloxy-8,9-epoxythymol isobutyrate (3) were also obtained. In this paper, we report the structures and complete assignments of the ¹H and (13)C-NMR data of compounds 1-7, and the absolute configuration for compound 1, unambiguously established by single crystal X-ray diffraction, and evaluation of the Flack parameter. The in vitro antiprotozoal assay showed that compound 1 and its derivative 1a were the most potent antiamoebic and antigiardial compounds. Both compounds showed selectivity and good antiamoebic activity comparable to emetine and metronidazole, respectively, two antiprotozoal drugs used as positive controls. In relation to anti-propulsive effect, compound 1 and 1a showed inhibitory activity, with activities comparable to quercetin and compound 9, two natural antipropulsive compounds used as positive controls. These data suggest that compound 1 may play an important role in antidiarrheal properties of Ageratina glabrata.

  2. Process for manufacturing bis(2-methoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracene

    DOEpatents

    Rasmussen, Paul George; Lawton, Richard Graham

    2014-06-03

    A process to manufacture substituted tetracyano-hexaazatricyclics with the substitutions occurring at the 9 and 10 hydrogens. The process begins with 2,3-dichloro-5,6-dicyanopyrazine, which is reacted to form the desired tetracyano-hexaazatricyclic. Different process embodiments enable different reaction paths to the desired tetracyano-hexaazatricyclic. Different tetracyano-hexaazatricyclic embodiments include bis(2-methoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracene and bis(2-methoxyethoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracen- e.

  3. Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.

    PubMed Central

    Buening, M K; Wislocki, P G; Levin, W; Yagi, H; Thakker, D R; Akagi, H; Koreeda, M; Jerina, D M; Conney, A H

    1978-01-01

    The tumorigenicities of benzo[a]pyrene and each optical enantiomer of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides derived from trans-7,8-dihydroxy-7,8-dihydrobenzol[a]pyrene were tested by sequential intraperitoneal injection of mice with 1,2, and 4 nmol, or with 2, 4, and 8 nmol of each compound on the 1st, 8th, and 15th day of life, respectively. The experiment was terminated when the animals were 34--37 weeks old. (+)-7beta, 8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzol[a]pyrene [(+)-BP-7beta,8alpha-diol-9alpha,10alpha-epoxide 2] had exceptional tumorigenicity, whereas benzo[a]-pyrene and the other three optically pure isomers of the benzo[a]pyrene 7,8-diol,9,10-epoxides had little or no activity. These results demonstrate differences in the carcinogenic activities of optically active isomers of a polycyclic hydrocarbon diol epoxide. Eleven percent of control mice had pulmonary tumors, whereas 71% and 100% of the mice treated with a total dose of 7 or 14 nmol of (+)-BP-7beta,8alpha-diol-9alpha,10alpha-epoxide 2, respectively, had pulmonary tumors. Control mice had an average of 0.12 pulmonary tumors per mouse, whereas mice treated with a total dose of 7 or 14 nmol of (+)-BP-7beta,8alpha-diol-9alpha,10alpha-epoxide 2 had 1.72 and 7.67 pulmonary tumors per mouse, respectively. Mice treated with 14 nmol of (-)-BP-7alpha,8beta-diol-9beta,10beta-epoxide 2, (-)-BP-7beta,8alpha-diol-9beta,10beta-epoxide 1, or (+)-BP-7alpha,8beta-diol-9alpha,10alpha-epoxide 1 had 0.13, 0.25, and 0.34 pulmonary tumors per animal, respectively. PMID:281685

  4. Quantitation of enantiomers of r-7,t-8,9,c-10-tetrahydroxy-7,8,9,10-tetrahydrobenzo[a]-pyrene in human urine: evidence supporting metabolic activation of benzo[a]pyrene via the bay region diol epoxide.

    PubMed

    Hecht, Stephen S; Hochalter, Jon Bradley

    2014-09-01

    Benzo[a]pyrene (BaP), a potent polycyclic aromatic hydrocarbon carcinogen, is widely distributed in the human environment. All humans are exposed to BaP through the diet and contact with the general environment; cigarette smokers have higher exposure. An important pathway of BaP metabolism proceeds through formation of diol epoxides including the 'bay region diol epoxide' 7R,8S-dihydroxy-9S,10R-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene [BaP-(7R,8S)-diol-(9S,10R)-epoxide] and the 'reverse diol epoxide' 9S,10R-dihydroxy-7R,8S-epoxy-7,8,9,10-tetrahydrobenzo [a]pyrene [BaP-(9S,10R)-diol-(7R,8S)-epoxide]. The bay region diol epoxide is considered a major ultimate carcinogen of BaP based on studies in cell culture and laboratory animals, but the available data in humans are less convincing. The bay region diol epoxide and the reverse diol epoxide react with H2O to produce enantiomeric BaP-tetraols that are excreted in the urine. We used chiral stationary-phase high-performance liquid chromatography and gas chromatography-negative ion chemical ionisation-tandem mass spectrometry to quantify these enantiomeric BaP-tetraols in the urine of 25 smokers and 25 non-smokers. The results demonstrated that the BaP-tetraol enantiomer representing the carcinogenic bay region diol epoxide pathway accounted for 68±6% (range 56-81%) of total BaP-tetraol in smokers and 64±6% (range 46-78%) in non-smokers. Levels of the major BaP-tetraol enantiomer decreased by 75% in smokers who quit smoking. These data provide convincing evidence in support of the bay region diol epoxide mechanism of BaP carcinogenesis in humans.

  5. The increase of serum Bcl-2 concentration in moderate head injury outcome: The role of ACTH4-10Pro8-Gly9-Pro10

    PubMed Central

    Indharty, Rr Suzy

    2013-01-01

    Background: Traumatic brain injury (TBI) is one of the major causes of death and disability. Apoptosis after TBI contributes significantly to the final extent of tissue damage. The Bcl-2 family proteins are important apoptosis modulators which increased in injured neurons. Bcl-2 has shown an antiapoptotic effect in rats and mice. ACTH4-10Pro8-Gly9-Pro10 is a synthetic short fragment of ACTH devoid of hormonal effects and has neuromodulatory properties. ACTH4-10Pro8-Gly9-Pro10 has been shown to increase levels of Bcl-2 and BDNF in vitro as well as in vivo. It has been postulated that ACTH4-10Pro8-Gly9-Pro10 will result in improved clinical outcome and reduce hospital length of stay. The goal of this study is to compare the effect of standard therapy only with standard therapy and ACTH4-10Pro8-Gly9-Pro10, the increase of Bcl-2, and clinical outcome with reduction of hospital stay. Materials and Methods: Subjects of moderate head injury (MHI) with no indication of surgery were taken consecutively (n = 40) and separated into two groups: standard treatment only and standard treatment combined with ACTH4-10Pro8-Gly9-Pro10. Blood samples were taken on day 1 and day 5 from each subject for measurements of Bcl-2 concentration. Barthel Index and MMSE were measured, at discharge and hospital length of stay was noted. Results: Forty subjects have been involved in this study, three subjects died in the standard therapy group, and one subject in ACTH4-10Pro8-Gly9-Pro10 group. Bcl-2 serum level in standard therapy was 1.39 ± 0.75 ng/mL on day 1 and 1.48 ± 0.77 ng/mL on day 5. After treatment with ACTH4-10Pro8-Gly9-Pro10, Bcl-2 level was 1.39 ± 0.70 ng/mL on day 1 and 3.70 ± 1.02 ng/mL on day 5. The serum Bcl-2 concentration was significantly increased with ACTH4-10Pro8-Gly9-Pro10 therapy with shorter hospital length of stay (P < 0.05). Conclusion: ACTH4-10Pro8-Gly9-Pro10 increased serum Bcl-2 levels and reduced hospital length of stay significantly compared with standard

  6. NMR solution structure of a nonanucleotide duplex with a dG mismatch opposite a 10R adduct derived from trans addition of a deoxyadenosine N6-amino group to (-)-(7S,8R,9R,10S)-7,8-dihydroxy-9,10-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene.

    PubMed

    Schurter, E J; Yeh, H J; Sayer, J M; Lakshman, M K; Yagi, H; Jerina, D M; Gorenstein, D G

    1995-01-31

    A nonanucleotide in which (-)-(7S,8R,9R,10S)-7,8-dihydroxy-9,10-epoxy- 7,8,9,10-tetrahydrobenzo[a]pyrene (7-hydroxy group and epoxide oxygen are trans) is covalently bonded to the exocyclic N6-amino group of deoxyadenosine through trans addition at C10 of the epoxide (10R adduct) has been synthesized. The modified oligonucleotide d(GGTCA*CGAG) was incorporated into the duplex d(GGTCA*CGAG).d(CTCGGGACC), containing a dG mismatch opposite the modified base (dA*). Proton assignments for the solution structure of the duplex containing the 10R adduct were made using 2D TOCSY and NOESY NMR spectra. The complete hybrid relaxation matrix program, MORASS2.0, was used to generate NOESY distance constraints for iterative refinement using distance-restrained molecular dynamics calculations with AMBER4.0. The iteratively refined structure showed the hydrocarbon intercalated from the major groove immediately below the dC4-dG15 base pair and oriented toward the 5'-end of the modified strand. The modified dA is in an anti configuration, with the dG of the GA mismatch turned out into the major groove. Chemical shifts of the hydrocarbon protons and unusual chemical shifts of sugar protons were accounted for by this orientation of the adduct. The information available currently provides the foundation for the rational explanation of observed benzo[a]pyrene (BaP) structures and predictions for other BaP dG and dA adducts.

  7. (4bS,8aS)-1-Isopropyl-4b,8,8-trimethyl-4b,5,6,7,8,8a,9,10-octa­hydro­phenan­thren-2-yl acetate

    PubMed Central

    Oubabi, Radouane; Auhmani, Aziz; Ait Itto, My Youssef; Auhmani, Abdelwahed; Daran, Jean-Claude

    2014-01-01

    The hemisynthesis of the title compound, C22H32O2, was carried out through direct acetyl­ation reaction of the naturally occurring diterpene totarol [systematic name: (4bS,8aS)-4b,8,8-trimethyl-1-propan-2-yl-5,6,7,8a,9,10-hexa­hydro­phen­an­thren-2-ol]. The mol­ecule is built up from three fused six membered rings, one saturated and two unsaturated. The central unsaturated ring has a half-chair conformation, whereas the other unsaturated ring displays a chair conformation. The absolute configuration is deduced from the chemical pathway. The value of the Hooft parameter [−0.10 (6)] allowed this absolute configuration to be confirmed. PMID:24765017

  8. Mucopolysaccharidosis IIIB confers enhanced neonatal intracranial transduction by AAV8 but not by 5, 9 or rh10

    PubMed Central

    Gilkes, J A; Bloom, M D; Heldermon, C D

    2016-01-01

    Sanfilippo syndrome type B (mucopolysaccharidosis IIIB, MPS IIIB) is a lysosomal storage disease resulting from deficiency of N-acetyl-glucosaminidase (NAGLU) activity. To determine the possible therapeutic utility of recombinant adeno-associated virus (rAAV) in early gene therapy-based interventions, we performed a comprehensive assessment of transduction and biodistribution profiles of four central nervous system (CNS) administered rAAV serotypes, -5, -8, -9 and -rh10. To simulate optimal earliest treatment of the disease, each rAAV serotype was injected into the CNS of neonatal MPS IIIB and control animals. We observed marked differences in biodistribution and transduction profiles between the serotypes and this differed in MPS IIIB compared with healthy control mice. Overall, in control mice, all serotypes performed comparably, although some differences were observed in certain focal areas. In MPS IIIB mice, AAV8 was more efficient than AAV5, -9 and -rh10 for gene delivery to most structures analyzed, including the cerebral cortex, hippocampus and thalamus. Noteworthy, the pattern of biodistribution within the CNS varied by serotype and genotype. Interestingly, AAV8 also produced the highest green fluorescent protein intensity levels compared with any other serotype and demonstrated improved transduction in NAGLU compared with control brains. Importantly, we also show leakage of AAV8, -9 and -rh10, but not AAV5, from CNS parenchyma to systemic organs. Overall, our data suggest that AAV8 represents the best therapeutic gene transfer vector for early intervention in MPS IIIB. PMID:26674264

  9. PB2-588 V promotes the mammalian adaptation of H10N8, H7N9 and H9N2 avian influenza viruses

    PubMed Central

    Xiao, Chencheng; Ma, Wenjun; Sun, Na; Huang, Lihong; Li, Yaling; Zeng, Zhaoyong; Wen, Yijun; Zhang, Zaoyue; Li, Huanan; Li, Qian; Yu, Yuandi; Zheng, Yi; Liu, Shukai; Hu, Pingsheng; Zhang, Xu; Ning, Zhangyong; Qi, Wenbao; Liao, Ming

    2016-01-01

    Human infections with avian influenza H7N9 or H10N8 viruses have been reported in China, raising concerns that they might cause human epidemics and pandemics. However, how these viruses adapt to mammalian hosts is unclear. Here we show that besides the commonly recognized viral polymerase subunit PB2 residue 627 K, other residues including 87E, 292 V, 340 K, 588 V, 648 V, and 676 M in PB2 also play critical roles in mammalian adaptation of the H10N8 virus. The avian-origin H10N8, H7N9, and H9N2 viruses harboring PB2-588 V exhibited higher polymerase activity, more efficient replication in mammalian and avian cells, and higher virulence in mice when compared to viruses with PB2-588 A. Analyses of available PB2 sequences showed that the proportion of avian H9N2 or human H7N9 influenza isolates bearing PB2-588 V has increased significantly since 2013. Taken together, our results suggest that the substitution PB2-A588V may be a new strategy for an avian influenza virus to adapt mammalian hosts. PMID:26782141

  10. PB2-588 V promotes the mammalian adaptation of H10N8, H7N9 and H9N2 avian influenza viruses.

    PubMed

    Xiao, Chencheng; Ma, Wenjun; Sun, Na; Huang, Lihong; Li, Yaling; Zeng, Zhaoyong; Wen, Yijun; Zhang, Zaoyue; Li, Huanan; Li, Qian; Yu, Yuandi; Zheng, Yi; Liu, Shukai; Hu, Pingsheng; Zhang, Xu; Ning, Zhangyong; Qi, Wenbao; Liao, Ming

    2016-01-19

    Human infections with avian influenza H7N9 or H10N8 viruses have been reported in China, raising concerns that they might cause human epidemics and pandemics. However, how these viruses adapt to mammalian hosts is unclear. Here we show that besides the commonly recognized viral polymerase subunit PB2 residue 627 K, other residues including 87E, 292 V, 340 K, 588 V, 648 V, and 676 M in PB2 also play critical roles in mammalian adaptation of the H10N8 virus. The avian-origin H10N8, H7N9, and H9N2 viruses harboring PB2-588 V exhibited higher polymerase activity, more efficient replication in mammalian and avian cells, and higher virulence in mice when compared to viruses with PB2-588 A. Analyses of available PB2 sequences showed that the proportion of avian H9N2 or human H7N9 influenza isolates bearing PB2-588 V has increased significantly since 2013. Taken together, our results suggest that the substitution PB2-A588V may be a new strategy for an avian influenza virus to adapt mammalian hosts.

  11. Development of seal ring carbon-graphite materials (tasks 8, 9, and 10)

    NASA Technical Reports Server (NTRS)

    Fechter, N. J.; Petrunich, P. S.

    1973-01-01

    A screening study was conducted to develop improved carbon-graphite materials for use in self-acting seals at air temperatures to 1300 F (704 C). Property measurements on materials prepared during this study have shown that: (1) The mechanical properties of a carbon-graphite material were significantly improved by using a fine milled artificial graphite filler material and including intensive mixing, warm molding, and pitch impregnation in the processing; and (2) the oxidation resistance of a carbon-graphite material was improved by including fine milled boron carbide as an oxidation-inhibiting additive. These techniques were employed to develop a material that has 10 times more oxidation resistance than that of a widely used commercial grade and mechanical properties that approach those of the commercial grade.

  12. Prototropic μ-H(8,9) and μ-H(9,10) Tautomers Derived from the [nido-5,6-C2B8H11](-) Anion.

    PubMed

    Tok, Oleg L; Růžičková, Zdenka; Růžička, Aleš; Hnyk, Drahomír; Štíbr, Bohumil

    2016-10-17

    Reported is an unusual tautomeric behavior within the [nido-5,6-C2B8H11](-) (1a(-)) cage that has no precedence in the whole area of carborane chemistry. Isolated were two skeletal tautomers, anions [6-Ph-nido-5,6-C2B8H10-μ(8,9)](-) (2d(-)) and [5,6-Me2-nido-5,6-C2B8H9-μ(9,10)](-) (3b(-)), which differ in the positioning of the open-face hydrogen bridge. Their structures have been determined by X-ray diffraction analyses. The 3b(-)structure is stabilized by intermolecular interaction involving Et3NH(+) and B8-B9 and H8 atoms in the solid phase; however, its dissolution in CD3CN causes instant conversion to the more stable [5,6-Me2-nido-5,6-C2B8H9-μ(8,9)](-) (2b(-)) tautomer. The dynamic electron-correlation-based MP2/6-31G* computations suggest that the parent [nido-5,6-C2B8H11-μ(8,9)](-) (2a(-)) tautomer is 3.9 kcal·mol(-1) more stable than the [nido-5,6-C2B8H11-μ(9,10)](-) (3a(-)) counterpart and the μ(8,9) structure 2(-) is therefore the most stable tautomeric form in the solution, as was also demonstrated by multinuclear ((1)H, (11)B, and (13)C) NMR measurements on the whole series of C-substituted compounds.

  13. Crystal structure of ethyl 2-[9-(5-bromo-2-hy-droxy-phen-yl)-1,8-dioxo-1,2,3,4,5,6,7,8,9,10-deca-hydro-acridin-10-yl]acetate.

    PubMed

    Mohamed, Shaaban K; Akkurt, Mehmet; Jasinski, Jerry P; Abdelhamid, Antar A; Tamam, Asmaa H; Albayati, Mustafa R

    2015-12-01

    In the title compound, C23H24BrNO5, the central 1,4-di-hydro-pyridine ring of the 1,2,3,4,5,6,7,8,9,10-deca-hydro-acridine ring system adopts a half-chair conformation. The two cyclo-hexene rings fused to the central ring both have a twisted-boat conformation. The mean planes of the bromo-hydroxy-phenyl ring and the major and minor components of the disordered ethyl amino-acetate moiety make dihedral angles of 78.99 (12), 85.9 (2) and 88.3 (9)°, respectively, with the 1,4-di-hydro-pyridine ring. The terminal ethyl group of the ethyl amino-acetate moiety is disordered over two sets of sites with refined occupancies of 0.768 (17) and 0.232 (17). The mol-ecular conformation is stabilized by an intra-molecular O-H⋯O hydrogen bond, forming an S(8) ring motif. In the crystal, C-H⋯O hydrogen bonds connect the mol-ecules into layers parallel to (001), enclosing R 1 (2)(7) ring motifs.

  14. Syntheses of Anthracenones. 2. Preparation of 1,8-Dimethoxy- (Dimethylanthralin) and 4,5-Dihydroxy-9(10H)-anthracenone (Isoanthralin): A Revision.

    PubMed

    Prinz, Helge; Burgemeister, Thomas; Wiegrebe, Wolfgang; Müller, Klaus

    1996-04-19

    The reduction of 1,8-dimethoxyanthracenedione with zinc dust and aqueous ammonia gives a mixture of 1,8-dimethoxyanthracene and 4,5-dimethoxy-9(10H)-anthracenone, rather than the isomeric 1,8-dimethoxy-9(10H)-anthracenone (dimethylanthralin). This isomer was obtained exclusively using SnCl(2) in HCl and acetic acid as reducing agent at room temperature. The structure was confirmed to exist as the tautomeric 1,8-dimethoxy-9-hydroxyanthracene. Furthermore, the reduction of 1,8-diacetoxyanthracenedione with SnCl(2) in HCl and acetic acid leads to 1,8-dihydroxy-9(10H)-anthracenone (anthralin) rather than 4,5-dihydroxy-9(10H)-anthracenone (isoanthralin), which was prepared by ether cleavage of 4,5-dimethoxy-9(10H)-anthracenone. In light of these findings some biological studies on antipsoriatic anthracenones have to be reconsidered.

  15. Nevada Test Site Radionuclide Inventory and Distribution Program: Report No. 3, Areas 3, 7, 8, 9, and 10

    SciTech Connect

    McArthur, R D; Mead, S W

    1987-02-01

    As part of the Nevada Test Site Radionuclide Inventory and Distribution Program, 115 soil samples were collected and more than 1200 in situ measurements of gamma-emitting radionuclides were made in the northern and eastern parts of Yucca Flat. Analysis of the data led to estimated inventories of 215 Ci of /sup 239,240/Pu, 128 Ci of /sup 137/Cs, 92 Ci of /sup 90/Sr, 36 Ci each of /sup 241/Am and /sup 60/Co, 31 Ci of /sup 102m/Rh, 27 Ci of /sup 238/Pu, 25 Ci of /sup 174/Lu, 10 Ci of /sup 152/Eu, 8 Ci of /sup 155/Eu, 7 Ci of /sup 154/Eu, 5 Ci of /sup 125/Sb, 4 Ci of /sup 101/Rh, and 2 Ci of /sup 134/Cs in the surface soil of the accessible portion of Areas 8 and 10. Similar calculations with the data from Areas 3, 7, and 9 gave estimates of 145 Ci of /sup 239,240/Pu, 89 Ci of /sup 152/Eu, 62 Ci of /sup 90/Sr, 25 Ci of /sup 137/Cs, 14 Ci of /sup 154/Eu, 11 Ci of /sup 241/Am, 6 Ci each of /sup 60/Co and /sup 238/Pu, and 4 Ci of /sup 155/Eu. Additional in situ measurements at 30 locations in the southern part of Yucca Flat confirmed the low levels of radioactivity found there by an aerial survey. 1 ref., 57 figs., 10 tabs.

  16. 40 CFR 721.10022 - Benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Significant New Uses for Specific Chemical Substances § 721.10022 Benzenamine, N-phenyl-, ar′-(C9-rich C8-10... chemical substance identified as benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  17. 40 CFR 721.10022 - Benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Significant New Uses for Specific Chemical Substances § 721.10022 Benzenamine, N-phenyl-, ar′-(C9-rich C8-10... chemical substance identified as benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  18. 40 CFR 721.10022 - Benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Significant New Uses for Specific Chemical Substances § 721.10022 Benzenamine, N-phenyl-, ar′-(C9-rich C8-10... chemical substance identified as benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  19. 40 CFR 721.10022 - Benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Significant New Uses for Specific Chemical Substances § 721.10022 Benzenamine, N-phenyl-, ar′-(C9-rich C8-10... chemical substance identified as benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  20. 40 CFR 721.10022 - Benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Significant New Uses for Specific Chemical Substances § 721.10022 Benzenamine, N-phenyl-, ar′-(C9-rich C8-10... chemical substance identified as benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  1. Overexpression of ALDH10A8 and ALDH10A9 Genes Provides Insight into Their Role in Glycine Betaine Synthesis and Affects Primary Metabolism in Arabidopsis thaliana.

    PubMed

    Missihoun, Tagnon D; Willée, Eva; Guegan, Jean-Paul; Berardocco, Solenne; Shafiq, Muhammad R; Bouchereau, Alain; Bartels, Dorothea

    2015-09-01

    Betaine aldehyde dehydrogenases oxidize betaine aldehyde to glycine betaine in species that accumulate glycine betaine as a compatible solute under stress conditions. In contrast, the physiological function of betaine aldehyde dehydrogenase genes is at present unclear in species that do not accumulate glycine betaine, such as Arabidopsis thaliana. To address this question, we overexpressed the Arabidopsis ALDH10A8 and ALDH10A9 genes, which were identified to code for betaine aldehyde dehydrogenases, in wild-type A. thaliana. We analysed changes in metabolite contents of transgenic plants in comparison with the wild type. Using exogenous or endogenous choline, our results indicated that ALDH10A8 and ALDH10A9 are involved in the synthesis of glycine betaine in Arabidopsis. Choline availability seems to be a factor limiting glycine betaine synthesis. Moreover, the contents of diverse metabolites including sugars (glucose and fructose) and amino acids were altered in fully developed transgenic plants compared with the wild type. The plant metabolic response to salt and the salt stress tolerance were impaired only in young transgenic plants, which exhibited a delayed growth of the seedlings early after germination. Our results suggest that a balanced expression of the betaine aldehyde dehydrogenase genes is important for early growth of A. thaliana seedlings and for salt stress mitigation in young seedlings.

  2. ATP-dependent transport of glutathione conjugate of 7beta, 8alpha-dihydroxy-9alpha,10alpha-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene in murine hepatic canalicular plasma membrane vesicles.

    PubMed Central

    Srivastava, S K; Hu, X; Xia, H; Bleicher, R J; Zaren, H A; Orchard, J L; Awasthi, S; Singh, S V

    1998-01-01

    Glutathione (GSH) S-transferases (GSTs) have an important role in the detoxification of (+)-anti-7,8-dihydroxy-9,10-oxy-7,8,9, 10-tetrahydrobenzo[a]pyrene [(+)-anti-BPDE], which is the ultimate carcinogen of benzo[a]pyrene. However, the fate and/or biological activity of the GSH conjugate of (+)-anti-BPDE [(-)-anti-BPD-SG] is not known. We now report that (-)-anti-BPD-SG is a competitive inhibitor (Ki 19 microM) of Pi-class isoenzyme mGSTP1-1, which among murine hepatic GSTs is most efficient in the GSH conjugation of (+)-anti-BPDE. Thus the inhibition of mGSTP1-1 activity by (-)-anti-BPD-SG might interfere with the GST-catalysed GSH conjugation of (+)-anti-BPDE unless one or more mechanisms exist for the removal of the conjugate. The results of the present study indicate that (-)-anti-BPD-SG is transported across canalicular liver plasma membrane (cLPM) in an ATP-dependent manner. The ATP-dependent transport of (-)-anti-[3H]BPD-SG followed Michaelis-Menten kinetics (Km 46 microM). The ATP dependence of the (-)-anti-BPD-SG transport was confirmed by measuring the stimulation of ATP hydrolysis (ATPase activity) by the conjugate in the presence of cLPM protein, which also followed Michaelis-Menten kinetics. In contrast, a kinetic analysis of ATP-dependent uptake of the model conjugate S-[3H](2,4-dinitrophenyl)-glutathione ([3H]DNP-SG) revealed the presence of a high-affinity and a low-affinity transport system in mouse cLPM, with apparent Km values of 18 and 500 microM respectively. The ATP-dependent transport of (-)-anti-BPD-SG was inhibited competitively by DNP-SG (Ki 1.65 microM). Likewise, (-)-anti-BPD-SG was found to be a potent competitive inhibitor of the high-affinity component of DNP-SG transport (Ki 6.3 microM). Our results suggest that GST-catalysed conjugation of (+)-anti-BPDE with GSH, coupled with ATP-dependent transport of the resultant conjugate across cLPM, might be the ultimate detoxification pathway for this carcinogen. PMID:9620885

  3. 40 CFR 721.10023 - Benzenamine, N-phenyl-, ar ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Benzenamine, N-phenyl-, ar arâ²-(C9... Significant New Uses for Specific Chemical Substances § 721.10023 Benzenamine, N-phenyl-, ar ar′-(C9-rich C8...) The chemical substance identified as benzenamine, N-phenyl-, ar,ar′-(C9-rich C8-10-branched...

  4. 40 CFR 721.10023 - Benzenamine, N-phenyl-, ar ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Benzenamine, N-phenyl-, ar arâ²-(C9... Significant New Uses for Specific Chemical Substances § 721.10023 Benzenamine, N-phenyl-, ar ar′-(C9-rich C8...) The chemical substance identified as benzenamine, N-phenyl-, ar,ar′-(C9-rich C8-10-branched...

  5. 40 CFR 721.10023 - Benzenamine, N-phenyl-, ar ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Benzenamine, N-phenyl-, ar arâ²-(C9... Significant New Uses for Specific Chemical Substances § 721.10023 Benzenamine, N-phenyl-, ar ar′-(C9-rich C8...) The chemical substance identified as benzenamine, N-phenyl-, ar,ar′-(C9-rich C8-10-branched...

  6. Molecular characterization of mutation and comparison of mutation profiles in the hprt gene of Chinese hamster ovary cells treated with benzo[a]pyrene trans-7,8-diol-anti-9,10-epoxide, 1-nitrobenzol[a]pyrene trans-7,8-diol-anti-9,10-epoxide, and 3-nitrobenzol[a]pyrene trans-7,8-diol-anti-9,10-epoxide

    SciTech Connect

    Zhan, D.J.; Heflich, R.H.; Fu, P.P.

    1996-12-31

    Both 1- and 3-nitrobenzol[a] pyrene (nitro-BaP) are environmental contaminants, potent mutagens in Salmonella, and moderate mutagens in Chinese hamster ovary (CHO) cells. The mutagenicity of their oxidized metabolites, trans-7,8-dihydroxy-anti-9, 10-epoxy-7,8,9,10-tetrahydro-1-nitrobenzol[a]pyrene (1-nitro-BaP-DE) and trans-7,8-dihydroxy-anti-9, 10-epoxy-7,8,9,10-tetrahydro-3-nitrobenzo[a]pyrene (3-nitro-BaP-DE), together with trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzol[a]pyren (BaP-DE), was determined in CHO-K1 cells, and the resulting mutations at the hprt locus were characterized by polymerase chain reaction (PCR) amplification of reverse-transcribed hprt mRNA, followed by DNA sequence analysis. The mutant frequencies, in mutants/10{sup 6} clonable cells, at 30 and 100 ng/ml, were BaP-DE, 248 and 456; 1-nitro-BaP-DE, 68 and 260; 3-nitro-BaP-DE, 81 and 232, respectively. In general, the three diolepoxides exhibited similar mutational spectra: (1) 64% (23/36 sequenced mutants) of BaP-DE, 53% (19/36) of 1-nitro-BaP-DE, and 64% (23/36) of 3-nitro-BaP-DE mutants resulted from simple base pair substitution, with the predominant mutation being G{r_arrow}T transversion: (2) 90%, 100%, and 100% of mutations at G:C had the mutated dG on the nontranscribed DNA strand; and (3) about one quarter of the mutants produced by each mutagen had one or more PCR products with partial or complete exon deletions. 61 refs., 1 fig., 7 tabs.

  7. Armed Services Vocational Aptitude Battery (ASVAB): Alternate Forms Reliability (Forms 8, 9, 10, and 11). Technical Paper for Period October 1980-April 1985.

    ERIC Educational Resources Information Center

    Palmer, Pamla; And Others

    A study investigated the alternate forms reliability of the Armed Services Vocational Aptitude Battery (ASVAB) Forms 8, 9, 10, and 11. Usable data were obtained from 62,938 armed services applicants who took the ASVAB in January and February 1983. Results showed that the parallel forms reliability coefficients between ASVAB Form 8a and the…

  8. S100A8/A9 mRNA Induction in an Ex Vivo Model of Endotoxin Tolerance: Roles of IL-10 and IFNγ

    PubMed Central

    Peronnet, Estelle; Turrel-Davin, Fanny; Piriou, Vincent; Pachot, Alexandre; Monneret, Guillaume; Lepape, Alain; Venet, Fabienne

    2014-01-01

    Objectives Septic syndromes are the leading cause of death in intensive care units. They are characterized by the development of immune dysfunctions such as endotoxin tolerance (ET), whose intensity and duration are associated with increased risk of nosocomial infections and mortality. Alarmins S100A8 and S100A9 have been shown to be increased after septic shock. Importantly, a delayed S100A9 mRNA increase predicts hospital-acquired infection in patients. The aim of this study was to investigate the regulation of S100A8 and S100A9 mRNA expression in an ex vivo model of ET. Subjects and Measurements ET was reproduced ex vivo by priming healthy peripheral blood mononuclear cells (number of donors  = 9 to 10) with low-dose endotoxin (2 ng/ml) before stimulation with high dose endotoxin (100 ng/ml). S100A8 and S100A9 mRNA levels were measured by quantitative real-time polymerase chain reactions. Main Results ET was established by observing decreased TNFα and increased IL-10 transcriptomic responses to two subsequent endotoxin challenges. Interestingly, ET was associated with increased S100A8 and S100A9 mRNA expression ex vivo. We showed that IL-10 played a role in this process, since S100A8 and S100A9 mRNA increases were significantly abrogated by IL-10 blockade in the model. Conversely, treatment with rIFN-γ, a pro-inflammatory and immunostimulating molecule known to block ET induction, was able to restore normal S100A8 and S100A9 mRNA in this model. Conclusions In this ex vivo model, we observed that S100A8 and S100A9 mRNA expression was significantly increased during ET. This reproduced ex vivo the observations we had previously made in septic shock patients. Interestingly, IL-10 blockade and rIFN-γ treatment partially abrogated S100A8/A9 mRNA increases in this model. Pending confirmation in larger, independent clinical studies, these preliminary results suggest that S100A8 and S100A9 mRNA levels might be used as surrogate markers of ET and as stratification

  9. Validation of the Armed Services Vocational Aptitude Battery (ASVAB) Forms 6 and 7 with Applications to ASVAB Forms 8, 9, and 10,

    DTIC Science & Technology

    1981-02-01

    important important MK 151 23 ’ Math AR 2 17 12 42 NO 0 7 WK 1 810 24 Verbal GS 6 8 10 24 GI 1 4 MC 6j 8 EI 0 8 * Shop SI 0 3 24 AI 1 5 CE 0 2 CA 01 2...MK test is by far the most important test in the battery. Tests from the math, verbal , and shop content areas are seen to be important both singly and...Symbol ASVAB 8/9/10 ASVAB 6/7 General Science GS / Arithmetic Reasoning AR V V Word Knowledge YK Paragraph Comprehension PC V ( Verbal - PC + WK) VE I

  10. Factor Structure of the Armed Services Vocational Aptitude Battery (ASVAB), Forms 8, 9, and 10: 1981 Army Applicant Sample. Technical Report 581.

    ERIC Educational Resources Information Center

    Kass, Richard A.; And Others

    The purpose of this research is to examine the factor structure of the Armed Services Vocational Aptitude Battery (ASVAB), Forms 8, 9, and 10. The ASVAB consists of ten subtests: General Science; Arithmetic Reasoning; Word Knowledge; Paragraph Comprehension; Numerical Operations; Coding Speed; Auto Shop Information; Mathematics Knowledge;…

  11. New gastroprotective labdeneamides from (4S,9R,10R) methyl 18-carboxy-labda-8,13(E)-diene-15-oate.

    PubMed

    Olate, Verónica Rachel; Pertino, Mariano Walter; Theoduloz, Cristina; Yesilada, Erdem; Monsalve, Francisco; González, Paulo; Droguett, Daniel; Richomme, Pascal; Hadi, A Hamid; Schmeda-Hirschmann, Guillermo

    2012-03-01

    Starting from the diterpene (4S,9R,10R) methyl 18-carboxy-labda-8,13(E)-dien-15-oate (PMD) and its 8(9)-en isomer [PMD 8(9)-en], 11 amides were prepared and assessed for a gastroprotective effect in the ethanol/HCl-induced gastric lesions model in mice. Basal cytotoxicity of the compounds was determined on the following human cell lines: normal lung fibroblasts (MRC-5), gastric epithelial adenocarcinoma (AGS), and hepatocellular carcinoma (Hep G2). All compounds are described for the first time. At the single oral dose of 0.1 mg/kg, compounds 1, 10, and 11 presented a strong gastroprotective effect, at least comparable with that of the reference compound lansoprazole at 1 mg/kg, reducing gastric lesions by 76.7, 67.7, and 77.2 %, respectively. The leucyl amide methyl ester 3, tryptophanyl amide methyl ester 5, and benzyl amide 6 of PMD presented a selective basal cytotoxicity on Hep G2 cells with IC₅₀ values of 136.8, 105.3, and 94.2 µM, respectively, while the IC₅₀ values towards AGS cells were 439.5, 928.0, and 937.3 µM, respectively. The three compounds did not affect fibroblast viability with IC₅₀ values > 1000 µM. Compounds 7, 8, 10, and 11 showed no toxic effect against the three selected cell lines.

  12. Crystal structure of 2-[9-(2-hy-droxy-phen-yl)-1,8-dioxo-1,2,3,4,5,6,7,8,9,10-deca-hydro-acridin-10-yl]acetic acid.

    PubMed

    Akkurt, Mehmet; Jasinski, Jerry P; Mohamed, Shaaban K; Allah, Omyma A Abd; Tamam, Asmaa H A; Albayati, Mustafa R

    2015-12-01

    The title compound, C21H21NO5, crystallizes with two mol-ecules in the asymmetric unit. In each mol-ecule, the central 1,4-di-hydro-pyridine ring adopts a shallow sofa conformations (with the C atom bearing the phenol ring as the flap), whereas the pendant cyclo-hexene rings both have twisted-boat conformations. Each mol-ecule features an intra-molecular O-H⋯O hydrogen bond, which closes an S(8) ring. In the crystal, the mol-ecules are linked by O-H⋯O, C-H⋯O and C-H⋯π inter-actions, forming a three-dimensional network.

  13. Molecular characterization of mutation and comparison of mutation profiles in the hprt gene of Chinese hamster ovary cells treated with benzo[a]pyrene trans-7,8-diol-anti-9,10-epoxide, 1-nitrobenzo[a]pyrene trans-7,8-diol-anti-9,10-epoxide, and 3-nitrobenzo[a]pyrene trans-7,8- diol-anti-9,10-epoxide.

    PubMed

    Zhan, D J; Heflich, R H; Fu, P P

    1996-01-01

    Both 1- and 3-nitrobenzo[a]pyrene (nitro-BaP) are environmental contaminants, potent mutagens in Salmonella, and moderate mutagens in Chinese hamster ovary (CHO) cells. The mutagenicity of their oxidized metabolites,trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-epoxy -7,8,9,10-tetrahydro-1-nitrobenzo[a]pyrene (1-nitro-BaP-DE) and trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydro-3-nitrobenzo[a]- pyrene (3-nitro-BaPDE), together with trans-7,8-dihydroxy-anti-9, 10-ep- oxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BaP-DE), was determined in CHO-K1 cells, and the resulting mutations at the hprt locus were characterized by polymerase chain reaction (PCR) amplification of reverse-transcribed hprt mRNA, followed by DNA sequence analysis. The mutant frequencies, in mutants/10(6) clonable cells, at 30 and 100 ng/ml, were BaP-DE, 248 and 456; 1-nitro-BaP-DE, 68 and 260; 3-nitro-BaP-DE, 81 and 232, respectively. In general, the three diolepoxides exhibited similar mutational spectra: 1) 64% (23/36 sequenced mutants) of BaP-DE, 53% (19/36) of 1-nitro-BaP-DE, and 64% (23/36) of 3-nitro-BaP-DE mutants resulted from simple base pair substitution, with the predominant mutation being G-->T transversion; 2) 90%, 100%, and 100% of mutations at G:C had the mutated dG on the nontranscribed DNA strand; and 3) about one quarter of the mutants produced by each mutagen had one or more PCR products with partial or complete exon deletions. The mutagens induced few frameshifts or complex mutations. Among the differences in mutational specificity for the three diolepoxides, the proportion of substituted dGs with 3' purines was significant (P < 0.05) for BaP-DE (16/19, 84%) and 3-nitro-BaP-DE (17/20, 85%), but not significant for 1-nitro-BaP-DE-induced mutants (11/17, 65%, P > 0.05). Also, high proportions of BaP-DE and 3-nitro-BaP-DE base pair substitutions at G:C occurred in DNA sequence contexts of 5'-GG-3', 5'-GGA-3', and 5'-TGGA-3', while the proportions of 1-nitro-BaP-DE mutants in these

  14. Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody.

    PubMed

    Hoff, Sebastian; Zeller, Florian; von Weyhern, Claus Werner Hann; Wegner, Michael; Schemann, Michael; Michel, Klaus; Rühl, Anne

    2008-08-01

    Quantitative changes of enteric glia (EGC) have been implicated in gastrointestinal disorders. To facilitate future studies of EGC in human pathology, we aimed to characterize thoroughly glial markers in the human enteric nervous system (ENS) and to compare EGC in man and guinea pig. Whole-mount preparations of the enteric nerve plexuses from human and guinea pig ileum and colon were labeled with antibodies against S100b, glial fibrillary acidic protein (GFAP), and p75NGFR and the transcription factors Sox8/9/10 and neuronally counterstained. Abundant immunoreactivity (IR) for S100b, GFAP, p75NGFR, and Sox8/9/10 was detected in EGC of all studied regions. Although the cytoplasmatic staining pattern of most markers did not permit glial quantification, the nuclear localization of Sox8/9/10-IR allowed to identify and count all EGC individually. In both man and guinea pig, myenteric ganglia were larger and contained more EGC and neurons than submucous ganglia. Furthermore, there were more EGC in the human than in the guinea pig myenteric plexus (MP), glial density was consistently higher in the human ENS, and the glia index (glia:neuron ratio) ranged from 1.3 to 1.9 and from 5.9 to 7.0 in the human submucous plexus (SMP) and MP, respectively, whereas, in guinea pig, the glia index was 0.8-1.0 in the SMP and 1.7 in the MP. The glia index was the most robust quantitative descriptor within one species. This is a comprehensive set of quantitative EGC measures in man and guinea pig that provides a basis for pathological assessment of glial proliferation and/or degeneration in the diseased gut.

  15. Skin-tumor-initiating ability of benzo(a)pyrene-7,8-diol-9,10-epoxide (anti) when applied topically in tetrahydrofuran.

    PubMed

    Slaga, T J; Viaje, A; Bracken, W M; Berry, D L; Fischer, S M; Miller, D R; Leclerc, S M

    1977-07-01

    The skin-tumor-initiating abilities of various metabolites of benzo(a)pyrene (BP) were determined in mice by using a two-stage system of tumorigenesis. We previously reported that BP-7,8-dihydrodiol (+/- trans) was approximately as potent as BP, suggesting that it may be a proximate carcinogen, but the alleged ultimate carcinogen of BP [BP-7,8-dihydrodiol-9,10-epoxide (anti)] was a weak tumor initiator (Cancer Lett.2: 115, 1976). Because of its high reactivity, the tumor-initiating ability of the BP-7,8-dihydrodiol-9,10-epoxide (anti) was determined by using acetone, benzene, and tetrahydrofuran (THF) as the solvent vehicles. The 'diol-epoxide' of BP was found to be an effective tumor initiator when applied topically in THF. The effectiveness of the various vehicles for the 'diol-epoxide' was as follows: THF greater than benzene greater than acetone; however, acetone was the best solvent for BP tumor initiation. The BP-9,10-dihydrodiol and BP-3-hydroxy were found to be weak tumor initiators. BP-3-hydroxy was also tested for tumor-promoting ability and was found to be inactive in this capacity.

  16. Efficient Catalyst One-Pot Synthesis of 7-(Aryl)-10,10-dimethyl-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione Derivatives Complemented by Antibacterial Activity

    PubMed Central

    Al-Majedy, Yasameen K.; Kadhum, Abdul Amir H.; Mohamad, Abu Bakar

    2016-01-01

    The problem of bacteria resistance to many known agents has inspired scientists and researchers to discover novel efficient antibacterial drugs. Three rapid, clean, and highly efficient methods were developed for one-pot synthesis of 7-(aryl)-10,10-dimethyl-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione derivatives. Three components are condensed in the synthesis, 4-hydroxycoumarin, 5,5-dimethyl-1,3-cyclohexanedione, and aromatic aldehydes, using tetrabutylammonium bromide (TBAB), diammonium hydrogen phosphate (DAHP), or ferric chloride (FeCl3), respectively. Each method has different reaction mechanisms according to the catalyst. The present methods have advantages, including one-pot synthesis, excellent yields, short reaction times, and easy isolation of product. All catalysts utilized in our study could be reused several times without losing their catalytic efficiency. All synthesized compounds were fully characterized and evaluated for their antibacterial activity. PMID:27563671

  17. Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10.

    PubMed

    Ekici, Ozlem Dogan; Li, Zhao Zhao; Campbell, Amy J; James, Karen Ellis; Asgian, Juliana L; Mikolajczyk, Jowita; Salvesen, Guy S; Ganesan, Rajkumar; Jelakovic, Stjepan; Grütter, Markus G; Powers, James C

    2006-09-21

    Aza-peptide Michael acceptors are a novel class of inhibitors that are potent and specific for caspases-2, -3, -6, -7, -8, -9, and -10. The second-order rate constants are in the order of 10(6) M(-1) s(-1). The aza-peptide Michael acceptor inhibitor 18t (Cbz-Asp-Glu-Val-AAsp-trans-CH=CH-CON(CH(2)-1-Naphth)(2) is the most potent compound and it inhibits caspase-3 with a k(2) value of 5620000 M(-1) s(-1). The inhibitor 18t is 13700, 190, 6.4, 594, 37500, and 173-fold more selective for caspase-3 over caspases-2, -6, -7, -8, -9, and -10, respectively. Aza-peptide Michael acceptors designed with caspase specific sequences are selective and do not show any cross reactivity with clan CA cysteine proteases such as papain, cathepsin B, and calpains. High-resolution crystal structures of caspase-3 and caspase-8 in complex with aza-peptide Michael acceptor inhibitors demonstrate the nucleophilic attack on C2 and provide insight into the selectivity and potency of the inhibitors with respect to the P1' moiety.

  18. Improved efficiency in organic light-emitting devices with tris-(8-hydroxyquinoline) aluminium doped 9,10-di(2-naphthyl) anthracene emission layer

    NASA Astrophysics Data System (ADS)

    Yuan, Yongbo; Lian, Jiarong; Li, Shuang; Zhou, Xiang

    2008-11-01

    Organic light-emitting devices with tris-(8-hydroxyquinoline) aluminium (Alq3) doped 9,10-di(2-naphthyl) anthracene (ADN) as the emission layer (EML) have been fabricated. These devices exhibit efficient electroluminescence (EL) originated from the Alq3 as the mass ratio of Alq3 to ADN was varied from 1 to 50%. The devices with an optimal Alq3 mass ratio of 10 wt% showed a peak EL efficiency and an external quantum efficiency of 9.1 cd A-1 and 2.7% at a luminance of 1371 cd m-2, which is improved by a factor of 2.2 compared with 4.1 cd A-1 and 1.2% at a luminance of 3267 cd m-2 for conventional devices with the neat Alq3 as the EML.

  19. Coexistence of Avian Influenza Virus H10 and H9 Subtypes among Chickens in Live Poultry Markets during an Outbreak of Infection with a Novel H10N8 Virus in Humans in Nanchang, China.

    PubMed

    Hu, Maohong; Li, Xiaodan; Ni, Xiansheng; Wu, Jingwen; Gao, Rongbao; Xia, Wen; Wang, Dayan; He, Fenglan; Chen, Shengen; Liu, Yangqing; Guo, Shuangli; Li, Hui; Shu, Yuelong; Bethel, Jeffrey W; Liu, Mingbin; Moore, Justin B; Chen, Haiying

    2015-01-01

    Infection with the novel H10N8 virus in humans has raised concerns about its pandemic potential worldwide. We report the results of a cross-sectional study of avian influenza viruses (AIVs) in live poultry markets (LPMs) in Nanchang, China, after the first human case of H10N8 virus infection was reported in the city. A total of 201 specimens tested positive for AIVs among 618 samples collected from 24 LPMs in Nanchang from December 2013 to January 2014. We found that the LPMs were heavily contaminated by AIVs, with H9, H10, and H5 being the predominant subtypes and more than half of the LPMs providing samples that were positive for the H10 subtype. Moreover, the coexistence of different subtypes was common in LPMs. Of the 201 positive samples, 20.9% (42/201) had mixed infections with AIVs of different HA subtypes. Of the 42 mixed infections, 50% (21/42) showed the coexistence of the H9 and H10 subtypes, with or without H5, and were from chicken samples. This indicated that the H10N8 virus probably originated from segment reassortment of the H9 and H10 subtypes.

  20. Improved efficiency for green and red emitting electroluminescent devices using the same cohost composed of 9,10-di(2-naphthyl) anthracene and tris-(8-hydroxyquinolinato) aluminum

    NASA Astrophysics Data System (ADS)

    Zhu, Jianzhuo; Li, Wenlian; Chu, Bei; Yang, Dongfang; Zhang, Guang; Liu, Huihui; Chen, Yiren; Su, Zisheng; Wang, Junbo; Wu, Shuanghong

    2009-12-01

    We demonstrate highly efficient green and red fluorescence dyes-doped electroluminescent devices using cohost strategy. The cohost system is composed of tris-(8-hydroxyquinolinato) aluminum (Alq) and 9,10-di(2-naphthyl) anthracene (ADN). The maximum current efficiencies are increased by 54% and 104% for green and red devices by optimizing the ratio between ADN and Alq in the cohost compared to the conventional Alq single-host devices, respectively. We attribute the improvement of efficiencies to balanced hole and electron injection into the emitting layer, the enlarged width of recombination region and the multiple emission processes.

  1. 8,9-dihydroxy-8,9-dihydrodibenzo[a,l]pyrene is a potent morphological cell-transforming agent in C3H10T(1)/(2)Cl8 mouse embryo fibroblasts in the absence of detectable stable covalent DNA adducts.

    PubMed

    Nesnow, S; Davis, C; Padgett, W T; Adams, L; Yacopucci, M; King, L C

    2000-06-01

    The comparative genotoxic effects of racemic trans-8,9-dihydroxy-8, 9-dihydrodibenzo[a,l]pyrene (trans-DB[a,l]P-8,9-diol), the metabolic K-region dihydrodiol of dibenzo[a,l] pyrene (DB[a,l]P) (dibenzo[def, p]chrysene) and DB[a,l]P in transformable mouse embryo C3H10T(1)/(2)Cl8 (C3H10T(1)/(2)) fibroblasts was investigated. The C3H10T(1)/(2) mouse embryo morphological cell-transforming activities of these polycyclic aromatic hydrocarbons (PAHs) were assayed using concentration-response studies. At concentrations of 33 nM and above both trans-DB[a,l]P-8,9-diol and DB[a,l]P produced significant (and similar) numbers of type II and III foci per dish and numbers of dishes with type II and II foci. Concomitant cytotoxicity studies revealed a reduction in colony survival of approximately 25% up to 198 nM for both PAHs. DNA adducts of trans-DB[a,l]P-8,9-diol and DB[a,l]P in C3H10T(1)/(2) cells were analyzed by a (32)P-post-labeling TLC/HPLC method. No adducts were observed in the DNA of C3H10T(1)/(2) cells treated with trans-DB[a, l]P-8,9-diol at concentrations that induced morphological cell transformation. Under the same exposure and chromatographic conditions, DNA adducts of deoxyadenosine and deoxyguanosine derived from the fjord region anti-DB[a,l]P-11,12-diol-13,14-epoxide and syn-DB[a,l]P-11,12-diol-13,14-epoxide were observed in the DNA of DB[a,l]P-treated cells. These results indicate that trans-DB[a,l]P-8, 9-diol has intrinsic genotoxic activity equal to that of DB[a,l]P, based on morphological cell transformation of mouse embryo fibroblasts. The activity of trans-DB[a,l]P-8,9-diol is apparently not associated with the formation of observable stable covalent DNA adducts. These results suggest that under appropriate conditions, trans-DB[a,l]P-8,9-diol may serve as an intermediate in the genotoxicity of DB[a,l]P.

  2. Skin tumor initiating ability of benzo(a)pyrene 4,5- 7,5- and 7,8-diol-9,10-epoxides and 7,8-diol.

    PubMed

    Slaga, T J; Viaje, A; Betty, D L; Brachen, W; Buty, S G; Scribner, J D

    1976-11-01

    The skin tumor initiating abilities of both K-region and non-K-region epoxides of benzo(a)pyrene(BP) were determined in mice using a two-stage system of tumorigenesis. BP-4,5-epoxide and BP-7,8-dihydrodiol-9,10-epoxide (anti) were found to be weak tumor initiators whereas BP-7,8-epoxide had about a third of the activity as the parent hydrocarbon, BP. However, the 7,8-dihydrodiol of BP was found to be approximately as potent as BP suggesting that it may be a proximate carcinogen.

  3. CO2 laser photoacoustic measurements of ethanol absorption coefficients within infrared region of 9.2-10.8 μm

    NASA Astrophysics Data System (ADS)

    Ivascu, I. R.; Matei, C. E.; Patachia, M.; Bratu, A. M.; Dumitras, D. C.

    2016-06-01

    Absorption coefficients of the ethanol vapors at atmospheric pressure and room temperature were measured by photoacoustic technique using a cw, line-tunable, frequency-stabilized CO2 laser as radiation source. The spectrum of the employed CO2 laser includes 54 lines with wavelengths in the infrared region of 9.2-10.8 μm and power levels up to 4.7 W. Measurements revealed a predominant absorption for ethanol within 9.4 μm band of the CO2 laser spectrum, where the highest values of the absorption coefficients were recorded: 3.68 cm- 1 atm- 1 at 9R(20) line and 3.65 cm- 1 atm- 1 at 9R(22) line. The estimated detection range covers six orders of magnitude, from a minimum of 30 ppbV to a maximum of 4% concentration of ethanol in nitrogen, which proves the suitability of the photoacoustic technique for accurate measurements of the ethanol concentration in various applications.

  4. CO2 laser photoacoustic measurements of ethanol absorption coefficients within infrared region of 9.2-10.8 μm.

    PubMed

    Ivascu, I R; Matei, C E; Patachia, M; Bratu, A M; Dumitras, D C

    2016-06-15

    Absorption coefficients of the ethanol vapors at atmospheric pressure and room temperature were measured by photoacoustic technique using a cw, line-tunable, frequency-stabilized CO2 laser as radiation source. The spectrum of the employed CO2 laser includes 54 lines with wavelengths in the infrared region of 9.2-10.8μm and power levels up to 4.7W. Measurements revealed a predominant absorption for ethanol within 9.4μm band of the CO2 laser spectrum, where the highest values of the absorption coefficients were recorded: 3.68cm(-1)atm(-1) at 9R(20) line and 3.65cm(-1)atm(-1) at 9R(22) line. The estimated detection range covers six orders of magnitude, from a minimum of 30ppbV to a maximum of 4% concentration of ethanol in nitrogen, which proves the suitability of the photoacoustic technique for accurate measurements of the ethanol concentration in various applications.

  5. Benzo[a]pyrene-7,8-diol-9,10-epoxide causes caspase-mediated apoptosis in H460 human lung cancer cell line.

    PubMed

    Xiao, Hui; Rawal, Malika; Hahm, Eun-Ryeong; Singh, Shivendra V

    2007-11-15

    We have shown previously that wild-type p53 renders H460 human lung cancer cells more sensitive to apoptosis induction by environmental carcinogen benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE), but the mechanism of cell death is not fully understood. The present study provides insights into the mechanism by which BPDE causes apoptosis in H460 cells. Exposure of H460 cells to BPDE resulted in a concentration-dependent apoptotic cell death characterized by cleavage of poly(ADP-ribose)polymerase, DNA condensation, and apoptotic histone-associated DNA fragments released into the cytosol. The BPDE-mediated release of apoptotic histone-associated DNA fragments into the cytosol was also observed in a normal bronchial epithelial cell line BEAS-2B. The BPDE-induced apoptosis in H460 cells correlated with up-regulation of pro-apoptotic protein Bak, downregulation of anti-apoptotic Bcl-2 family members Bcl-2 and Bcl-xL, release of cytochrome c from mitochondria to the cytosol without a change in mitochondrial membrane potential or mitochondrial morphology (electron microscopy), and cleavage of caspase-8, -9, and -3. Ectopic expression of Bcl-2 failed to confer significant protection against BPDE-induced apoptosis in H460 cells. The SV40 immortalized mouse embryonic fibroblasts (MEFs) derived from Bak and Bax double knockout mice, but not Bid knockout mice, were significantly more resistant to BPDE-induced apoptosis compared with the MEFs derived from wild-type mice. The BPDE-induced apoptosis was partially but statistically significantly attenuated in the presence of specific inhibitors of caspase-9 (z-LEHDfmk) and caspase-8 (z-IETDfmk). In conclusion, the present study reveals that BPDE-induced apoptosis in H460 cells is associated with Bak induction and caspase activation but independent of Bcl-2.

  6. The d{sup 8}, d{sup 9} and d{sup 10} supermultiplets of NiH, PdH, and PtH

    SciTech Connect

    Field, R.W.; McCarthy, M.C.; Kanamori, H.; Steimle, T.

    1993-12-31

    The concept of integer oxidation states organizes an enormous body of structural and reactivity information. Yet, for gas phase diatomic molecules, oxidation states seem never to be taken seriously by either spectroscopists or quantum chemists. For MH, MO, MF, and MM{prime} diatomics, where M is a rare earth or transition metal, oxidation states can be defined by the near-integer occupancy of the (n{minus}1)d or (n{minus}2)f valence subshell. For example, the d{sup 8}, d{sup 9}, and d{sup 10} occupancies in the (NiH, PdH, PtH) family of molecules correspond respectively to M{sup 0}, M{sup +1}, and M{sup +2} oxidation states. Spin-orbit coupling plays a central role in controlling the pattern of low-lying states, the relative intensities of nominally forbidden electronic transitions, and the predissociative interaction strength between bound and repulsive electronic states. Also, since the atomic spin-orbit coupling constant {zeta}(nd) decreases by {approximately} 10% when an electron is added to the n{minus}1d subshell, the molecular spin-orbit parameters in a supermultiplet fit model can serve as diagnostic of the fractional characters of the various n{minus}1d{sup N} occupancies (i.e. oxidation states) for each of the MH, MF, and MCu electronic states. The NiH, PdH, PtH family of molecules provides an excellent opportunity to apply supermultiplet diagnostics because (i) the energy order of the d{sup 10}, d{sup 9}s, and d{sup 8}s{sup 2} configurations in the free M atom is different for (NiH, PtH) vs PdH; (ii) the n{minus}1d orbitals are maximally contracted.

  7. Translation of globin messenger RNA modified by benzo(a)pyrene 7,8-dihydrodiol 9,10-oxide in a wheat germ cell-free system

    SciTech Connect

    Grunberger, D.; Pergolizzi, R.G.; Jones, R.E.

    1980-01-25

    Poly(U/sub 3/G) and rabbit globin mRNA were modified with the active carcinogenic metabolite of benzo(a)pyrene, (+-)-7..beta..,8..cap alpha..-dihydroxy-9..cap alpha..,10..cap alpha..-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene, and the effects of modification on translation in a cell-free protein synthesizing system were studied. High performance liquid chromatography of modified nucleosides from enzymatically hydrolyzed globin mRNA reveals that the active carcinogen formed two adducts with guanosine, four adducts with adenosine, and one adduct probably with cytidine residues. When globin mRNA with 0.4 carcinogen residues/molecule is used as a template, incorporation of amino acids into proteins is inhibited by 50%, and mRNA with 2.4 residues has only 10% of the template activity compared to unmodified molecules. On the other hand, modification of poly(U/sub 3/G) has no effect on its template activity. Since no significant formation of smaller peptides in the protein synthesizing system programmed with modified mRNA is detected, it is suggested that the carcinogen does not block the elongation step in mRNA translation. However, glycerol gradient centrifugation of initiation complexes reveals that modified globin mRNA does not form initiation complexes with ribosomes as effectively as does the unmodified globin mRNA. These results suggest that modification significantly reduces the ability of mRNA to be translated by affecting the initiation step in protein synthesis.

  8. 1H, 13C NMR spectral and single crystal structural studies of toxaphene congeners. Quantum chemical calculations for preferred conformers of 2,5- endo,6- exo,8,9,9,10,10-octachloro-2-bornene and their DFT/GIAO 13C chemical shifts

    NASA Astrophysics Data System (ADS)

    Laihia, K.; Valkonen, A.; Kolehmainen, E.; Suontamo, R.; Nissinen, M.; Nikiforov, V.; Selivanov, S.

    2005-11-01

    The 1H and 13C NMR chemical shifts for six toxaphene congeners: 2- exo,3- endo,6- exo,8,9,10-hexachloro- ( 1), 2- exo,3- endo,5- exo,9,9,10,10-heptachloro- ( 2), 2- exo,3- endo,6- exo,8,9,10,10-heptachloro- ( 3), 2- exo,3- endo,5- exo,6- endo,8,9,10-heptachloro- ( 4), 2- exo,3- endo,5- exo,6- endo,8,9,9,10-octachlorobornane ( 5) and 2,5- endo,6- exo,8,9,9,10,10-octachloro-2-bornene ( 6) are reported. Their chemical shift assignments have been obtained by means of Pulsed Field Gradient (PFG) Double Quantum Filtered (DQF) 1H, 1H correlation spectroscopy (COSY), PFG 1H, 13C Heteronuclear Multiple Quantum Coherence (HMQC) and PFG 1H, 13C Heteronuclear Multiple Bond Correlation (HMBC) experiments. A single crystal X-ray structural analysis was made for compounds 1, 3, 4 and 6. The prevalences of two octachlorobornene rotamers ( 6 a, 6 b) were elucidated by ab initio MO method and single point DFT/GIAO calculations for 13C chemical shifts. Theoretical calculations proved that the single crystal structure of 6 corresponds its most stable conformer in solution.

  9. Crystal structure of (1S,3R,8R,9R)-2,2-di-chloro-3,7,7-tri-methyl-10-methylenetri-cyclo-[6.4.0.0(1,3)]dodecan-9-ol.

    PubMed

    Benzalim, Ahmed; Auhmani, Aziz; Bimoussa, Abdoullah; Ait Itto, My Youssef; Daran, Jean-Claude; Auhmani, Abdelwahed

    2016-08-01

    The title compound, C16H24Cl2O, was synthesized by treating (1S,3R,8S,9R,10S)-2,2-di-chloro-3,7,7,10-tetra-methyl-9,10-ep-oxy-tri-cyclo-[6.4.0.0(1,3)]dodecane with a concentrated solution of hydro-bromic acid. It is built up from three fused rings: a cyclo-heptane ring, a cyclo-hexyl ring bearing alkene and hy-droxy substituents, and a cyclo-propane ring bearing two chlorine atoms. The asymmetric unit contains two mol-ecules linked by an O-H⋯O hydrogen bond. In the crystal, further O-H⋯O hydrogen bonds build up an R 4 (4)(8) cyclic tetra-mer. One of the mol-ecules presents disorder that affects the seven-membered ring. In both mol-ecules, the six-membered rings display a chair conformation, whereas the seven-membered rings display conformations inter-mediate between boat and twist-boat for the non-disordered mol-ecule and either a chair or boat and twist-boat for the disordered mol-ecule owing to the disorder. The absolute configuration for both mol-ecules is 1S,3R,8R,9R and was deduced from the chemical pathway and further confirmed by the X-ray structural analysis.

  10. A new monohydrogendecavanadate (V)-dihydrogendecavanadate (V) with dibutylammonium cations [C8NH20]9[H2V10O28][HV10O28].2.13H2O: Synthesis, crystal structure, vibrational and optical properties

    NASA Astrophysics Data System (ADS)

    Omri, Issam; Mhiri, Tahar; Graia, Mohsen

    2016-03-01

    A new decavanadate, [C8NH20]9[H2V10O28][HV10O28].2.13H2O, was synthesized by slow evaporation from aqueous solution and characterized by IR, Raman and UV-Vis spectroscopies. The crystal structure was solved by single-crystal X-ray diffraction. [C8NH20]9[H2V10O28][HV10O28].2.13H2O consists of dihydrogendecavanadate [H2V10O28]4-, monohydrogendecavanadate [HV10O28]5-, dibutylammonium cations and water molecules. The decavanadate units are assembled in tetramers arrays by interanionic hydrogen bonds O-H···O and cation-anion N-H···O interactions. The dibutylammonium [C8NH20]+ cations and water molecules connect the tetramers into a three-dimensional network. The presence of the two types of units, [HnV10O28](6-n)- with n = 1 and n = 2, in one compound was not yet observed and is herein reported for the first time. The IR and Raman spectra exhibit characteristic bands of all groups present in the structure. The optical analysis shows that this compound is a semiconductor material with an optical band gap of 2.59 eV.

  11. Chemopreventive activity of chlorophyllin against mouse skin carcinogenesis by benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide.

    PubMed

    Park, K K; Surh, Y J

    1996-04-19

    Chlorophyllin (CHL), the sodium and copper salt of chlorophyll, was tested for its chemopreventive activity against tumorigenesis induced by benzo[a]pyrene (B[a]P) and its ultimate electrophilic and carcinogenic metabolite, benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide(BPDE). Administration of CHL (15 mg/kg body wt) by gavage to female ICR mice 30 min prior to a topical application of B[a]P or BPDE resulted in significant reduction in both incidence and multiplicity of skin tumors initiated by these carcinogens. CHL was rapidly distributed in the skin and other tissues of mice after oral administration. Taken together, these results suggest that CHL is a potential chemopreventive agent.

  12. 8 CFR 212.8-212.9 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false 212.8-212.9 Section 212.8-212.9 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS DOCUMENTARY REQUIREMENTS: NONIMMIGRANTS; WAIVERS; ADMISSION OF CERTAIN INADMISSIBLE ALIENS; PAROLE §§ 212.8-212.9...

  13. 49 CFR 8.9 - Information Security Review Committee.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Information Security Review Committee. 8.9 Section 8.9 Transportation Office of the Secretary of Transportation CLASSIFIED INFORMATION: CLASSIFICATION/DECLASSIFICATION/ACCESS Classification/Declassification of Information § 8.9 Information Security Review Committee. (a) There is hereby established...

  14. Uses of monoclonal antibody 8H9

    DOEpatents

    Cheung, Nai-Kong V.

    2013-04-09

    This invention provides a composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a suitable carrier. This invention provides a pharmaceutical composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a pharmaceutically acceptable carrier. This invention also provides an antibody other than the monoclonal antibody 8H9 comprising the complementary determining regions of monoclonal antibody 8H9 or a derivative thereof, capable of binding to the same antigen as the monoclonal antibody 8H9. This invention provides a substance capable of competitively inhibiting the binding of monoclonal antibody 8H9. This invention also provides an isolated scFv of monoclonal antibody 8H9 or a derivative thereof. This invention also provides the 8H9 antigen. This invention also provides different uses of the monoclonal antibody 8H9 or its derivative.

  15. Uses of monoclonal antibody 8H9

    DOEpatents

    Cheung, Nai-Kong V.

    2010-06-22

    This invention provides a composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a suitable carrier. This invention provides a pharmaceutical composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a pharmaceutically acceptable carrier. This invention also provides an antibody other than the monoclonal antibody 8H9 comprising the complementary determining regions of monoclonal antibody 8H9 or a derivative thereof, capable of binding to the same antigen as the monoclonal antibody 8H9. This invention provides a substance capable of competitively inhibiting the binding of monoclonal antibody 8H9. This invention also provides an isolated scFv of monoclonal antibody 8H9 or a derivative thereof. This invention also provides the 8H9 antigen. This invention also provides different uses of the monoclonal antibody 8H9 or its derivative.

  16. H and D attachment to naphthalene: spectra and thermochemistry of cold gas-phase 1-C10H9 and 1-C10H8D radicals and cations.

    PubMed

    Krechkivska, Olha; Wilcox, Callan M; Chan, Bun; Jacob, Rebecca; Liu, Yu; Nauta, Klaas; Kable, Scott H; Radom, Leo; Schmidt, Timothy W

    2015-04-02

    Excitation spectra of the 1H-naphthalene (1-C10H9) and 1D-naphthalene (1-C10H8D) radicals, and their cations, are obtained by laser spectroscopy and mass spectrometry of a skimmed free-jet expansion following an electrical discharge. The spectra are assigned on the basis of density functional theory calculations. Isotopic shifts in origin transitions, vibrational frequencies and ionization energies were found to be well reproduced by (time-dependent) density functional theory. Absolute bond dissociation energies, ionization energies and proton affinities were calculated using high-level quantum chemical methods.

  17. 32 CFR 9.8 - Authority.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Authority. 9.8 Section 9.8 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS PROCEDURES FOR TRIALS BY MILITARY COMMISSIONS OF CERTAIN NON-UNITED STATES CITIZENS IN THE WAR AGAINST TERRORISM § 9.8...

  18. 32 CFR 9.8 - Authority.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Authority. 9.8 Section 9.8 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS PROCEDURES FOR TRIALS BY MILITARY COMMISSIONS OF CERTAIN NON-UNITED STATES CITIZENS IN THE WAR AGAINST TERRORISM § 9.8...

  19. 32 CFR 9.8 - Authority.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Authority. 9.8 Section 9.8 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS PROCEDURES FOR TRIALS BY MILITARY COMMISSIONS OF CERTAIN NON-UNITED STATES CITIZENS IN THE WAR AGAINST TERRORISM § 9.8...

  20. 32 CFR 9.8 - Authority.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Authority. 9.8 Section 9.8 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS PROCEDURES FOR TRIALS BY MILITARY COMMISSIONS OF CERTAIN NON-UNITED STATES CITIZENS IN THE WAR AGAINST TERRORISM § 9.8...

  1. 32 CFR 9.8 - Authority.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Authority. 9.8 Section 9.8 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS PROCEDURES FOR TRIALS BY MILITARY COMMISSIONS OF CERTAIN NON-UNITED STATES CITIZENS IN THE WAR AGAINST TERRORISM § 9.8...

  2. Crystal structure of ethyl 2-[9-(5-bromo-2-hy­droxy­phen­yl)-1,8-dioxo-1,2,3,4,5,6,7,8,9,10-deca­hydro­acridin-10-yl]acetate

    PubMed Central

    Mohamed, Shaaban K.; Akkurt, Mehmet; Jasinski, Jerry P.; Abdelhamid, Antar A.; Tamam, Asmaa H.; Albayati, Mustafa R.

    2015-01-01

    In the title compound, C23H24BrNO5, the central 1,4-di­hydro­pyridine ring of the 1,2,3,4,5,6,7,8,9,10-deca­hydro­acridine ring system adopts a half-chair conformation. The two cyclo­hexene rings fused to the central ring both have a twisted-boat conformation. The mean planes of the bromo­hydroxy­phenyl ring and the major and minor components of the disordered ethyl amino­acetate moiety make dihedral angles of 78.99 (12), 85.9 (2) and 88.3 (9)°, respectively, with the 1,4-di­hydro­pyridine ring. The terminal ethyl group of the ethyl amino­acetate moiety is disordered over two sets of sites with refined occupancies of 0.768 (17) and 0.232 (17). The mol­ecular conformation is stabilized by an intra­molecular O—H⋯O hydrogen bond, forming an S(8) ring motif. In the crystal, C—H⋯O hydrogen bonds connect the mol­ecules into layers parallel to (001), enclosing R 1 2(7) ring motifs. PMID:26870566

  3. Translation of satellite tobacco necrosis virus RNA modified by (not equal to)-r-7,t-8-dihydroxy-t-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene is inhibited in a wheat germ cell-free system

    SciTech Connect

    Haas, R.; Pulkrabek, P.; Takanami, Y.; Grunberger, D.

    1983-01-01

    It has been shown that (not equal to)-r-7-,t-8-dihydroxy-t-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (BPDE) modification of rabbit globin mRNA results in inhibition of translational initiation. In order to explore the possibility that modification of the 5' cap structure was responsible for this inhibition, the naturally non-capped mRNA from satellite tobacco necrosis virus (STNV) was reacted with BPDE and translated in a wheat germ cell-free system. The extent of modification was 1.3 and 2.9 BPDE residues/molecule. High performance liquid chromatography of the modified nucleosides from enzymatically hydrolyzed STNV RNA revealed that greater than 90% of the nucleoside adducts were substituted at the exocyclic amino group of guanosine. The translational ability of the lower and higher modified STNV, measured by incorporation of (/sup 14/C)amino acids into acid-precipitable polypeptides is inhibited by 55% and 63%, respectively. Polyacrylamide gel electrophoretic analyses of the translation products indicate that predominantly full-length coat proteins are synthesized but with the carcinogen-modified STNV the amount is reduced. On the other hand, 80S initiation complex formation is not inhibited as measured by binding of the BPDE-modified STNV to ribosomes and followed by glycerol gradient centrifugation. Under these conditions, aurintricarboxylic acid completely inhibits 80S initiation complex formation in the presence of either modified or native STNV. These results suggest that inhibition of in vitro translation of BPDE-modified STNV, in contrast to that of globin mRNA, is not at the level of initiation complex formation but possibly by premature termination of growing polypeptides.

  4. Uses of monoclonal antibody 8H9

    DOEpatents

    Cheung, Nai-Kong V

    2013-08-06

    This invention provides a composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a suitable carrier. This invention provides a pharmaceutical composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a pharmaceutically acceptable carrier. This invention also provides an antibody other than the monoclonal antibody 8H9 comprising the complementary determining regions of monoclonal antibody 8H9 or a derivative thereof, capable of binding to the same antigen as the monoclonal antibody 8H9. This invention provides a substance capable of competitively inhibiting the binding of monoclonal antibody 8H9. This invention also provides an isolated scFv of monoclonal antibody 8H9 or a derivative thereof. This invention also provides the 8H9 antigen. This invention also provides a method of inhibiting the growth of tumor cells comprising contacting said tumor cells with an appropriate amount of monoclonal antibody 8H9 or a derivative thereof.

  5. Uses of monoclonal antibody 8H9

    DOEpatents

    Cheung, Nai-Kong V.

    2010-06-15

    This invention provides a composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a suitable carrier. This invention provides a pharmaceutical composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a pharmaceutically acceptable carrier. This invention also provides an antibody other than the monoclonal antibody 8H9 comprising the complementary determining regions of monoclonal antibody 8H9 or a derivative thereof, capable of binding to the same antigen as the monoclonal antibody 8H9. This invention provides a substance capable of competitively inhibiting the binding of monoclonal antibody 8H9. This invention also provides an isolated scFv of monoclonal antibody 8H9 or a derivative thereof. This invention also provides the 8H9 antigen. This invention also provides a method of inhibiting the growth of tumor cells comprising contacting said tumor cells with an appropriate amount of monoclonal antibody 8H9 or a derivative thereof.

  6. Anticonvulsant profiles of certain new 6-aryl-9-substituted-6,9-diazaspiro-[4.5]decane-8,10-diones and 1-aryl-4-substituted-1,4-diazaspiro[5.5]undecane-3,5-diones.

    PubMed

    Aboul-Enein, Mohamed N; El-Azzouny, Aida A; Attia, Mohamed I; Maklad, Yousreya A; Aboutabl, Mona E; Ragab, Fatma; Abd El-Hamid, Walaa H A

    2014-09-23

    Synthesis and anticonvulsant potential of certain new 6-aryl-9-substituted-6,9-diazaspiro[4.5]decane-8,10-diones (6a-l) and 1-aryl-4-substituted-1,4-diazaspiro[5.5] undecane-3,5-diones (6m-x) are reported. The intermediates 1-[(aryl)(cyanomethyl)amino] cycloalkanecarboxamides (3a-f) were prepared via adopting Strecker synthesis on the proper cycloalkanone followed by partial hydrolysis of the obtained nitrile functionality and subsequent N-cyanomethylation. Compounds 3a-f were subjected to complete nitrile hydrolysis to give the respective carboxylic acid derivatives 4a-f which were cyclized under mild conditions to give the spiro compounds 5a-f. Ultimately, compounds 5a-f were alkylated or aralkylated to give the target compounds 6a-i and 6m-u. On the other hand, compounds 6j-l and 6v-x were synthesized from the intermediates 5a-f through alkylation, dehydration and finally tetrazole ring formation. Anticonvulsant screening of the target compounds 6a-x revealed that compound 6g showed an ED50 of 0.0043 mmol/kg in the scPTZ screen, being about 14 and 214 fold more potent than the reference drugs, Phenobarbital (ED50 = 0.06 mmol/kg) and Ethosuximide (ED50 = 0.92 mmol/kg), respectively. Compound 6e exhibited an ED50 of 0.019 mmol/kg, being about 1.8 fold more potent than that of the reference drug, Diphenylhydantoin (ED50 = 0.034 mmol/kg) in the MES screen. Interestingly, all the test compounds 6a-x did not show any minimal motor impairment at the maximum administered dose in the neurotoxicity screen.

  7. Anticonvulsant Profiles of Certain New 6-Aryl-9-substituted-6,9-diazaspiro-[4.5]decane-8,10-diones and 1-Aryl-4-substituted-1,4-diazaspiro[5.5]undecane-3,5-diones

    PubMed Central

    Aboul-Enein, Mohamed N.; El-Azzouny, Aida A.; Attia, Mohamed I.; Maklad, Yousreya A.; Aboutabl, Mona E.; Ragab, Fatma; El-Hamid, Walaa H. A. Abd

    2014-01-01

    Synthesis and anticonvulsant potential of certain new 6-aryl-9-substituted-6,9-diazaspiro[4.5]decane-8,10-diones (6a–l) and 1-aryl-4-substituted-1,4-diazaspiro[5.5]undecane-3,5-diones (6m–x) are reported. The intermediates 1-[(aryl)(cyanomethyl)amino]cycloalkanecarboxamides (3a–f) were prepared via adopting Strecker synthesis on the proper cycloalkanone followed by partial hydrolysis of the obtained nitrile functionality and subsequent N-cyanomethylation. Compounds 3a–f were subjected to complete nitrile hydrolysis to give the respective carboxylic acid derivatives 4a–f which were cyclized under mild conditions to give the spiro compounds 5a–f. Ultimately, compounds 5a–f were alkylated or aralkylated to give the target compounds 6a–i and 6m–u. On the other hand, compounds 6j–l and 6v–x were synthesized from the intermediates 5a–f through alkylation, dehydration and finally tetrazole ring formation. Anticonvulsant screening of the target compounds 6a–x revealed that compound 6g showed an ED50 of 0.0043 mmol/kg in the scPTZ screen, being about 14 and 214 fold more potent than the reference drugs, Phenobarbital (ED50 = 0.06 mmol/kg) and Ethosuximide (ED50 = 0.92 mmol/kg), respectively. Compound 6e exhibited an ED50 of 0.019 mmol/kg, being about 1.8 fold more potent than that of the reference drug, Diphenylhydantoin (ED50 = 0.034 mmol/kg) in the MES screen. Interestingly, all the test compounds 6a–x did not show any minimal motor impairment at the maximum administered dose in the neurotoxicity screen. PMID:25250910

  8. 48 CFR 52.214-8-52.214-9 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false 52.214-8-52.214-9 Section 52.214-8-52.214-9 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses...

  9. 48 CFR 52.214-8-52.214-9 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false 52.214-8-52.214-9 Section 52.214-8-52.214-9 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses...

  10. 49 CFR 8.9 - Information Security Review Committee.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Information Security Review Committee. 8.9 Section.../DECLASSIFICATION/ACCESS Classification/Declassification of Information § 8.9 Information Security Review Committee. (a) There is hereby established a Department of Transportation Information Security Review...

  11. 49 CFR 8.9 - Information Security Review Committee.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false Information Security Review Committee. 8.9 Section.../DECLASSIFICATION/ACCESS Classification/Declassification of Information § 8.9 Information Security Review Committee. (a) There is hereby established a Department of Transportation Information Security Review...

  12. 49 CFR 8.9 - Information Security Review Committee.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false Information Security Review Committee. 8.9 Section.../DECLASSIFICATION/ACCESS Classification/Declassification of Information § 8.9 Information Security Review Committee. (a) There is hereby established a Department of Transportation Information Security Review...

  13. 49 CFR 8.9 - Information Security Review Committee.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Information Security Review Committee. 8.9 Section.../DECLASSIFICATION/ACCESS Classification/Declassification of Information § 8.9 Information Security Review Committee. (a) There is hereby established a Department of Transportation Information Security Review...

  14. Study of the nucleon radiative captures 8Li(n,γ)9Li, 9Be(p,γ)10B, 10Be(n,γ)11Be, 10B(p,γ)11C, and 16O(p,γ)17F at thermal and astrophysical energies

    NASA Astrophysics Data System (ADS)

    Dubovichenko, Sergey; Dzhazairov-Kakhramanov, Albert

    We have studied the neutron-capture reactions 8Li(n,γ)9Li and its role in the primordial nucleosynthesis. The n +8Li →9Li + γ reaction has a significant astrophysical interest because it includes one of the variants of chain of primordial nucleosynthesis processes of the Universe and thermonuclear reactions in type II supernovae. Furthermore, we consider the 9Be(p,γ)10B reaction in the astrophysical energy range in the modified potential cluster model (MPCM) with splitting of orbital states according to Young tableaux and, in some cases, with forbidden states (FS). The reaction 9Be(p,γ)10B plays an important role in primordial and stellar nucleosynthesis of light elements in the p shell. Hydrogen burning in second-generation stars occurs via the proton-proton (pp) chain and CNO cycle, with the 9Be(p,γ)10B reaction serving as an intermediate link between these cycles. Furthermore, the possibility of describing available experimental data for the total reaction cross-sections of neutron radiative capture on 10Be at thermal and astrophysical energies has been shown. This reaction is a part of one of the variants of the chain of primordial nucleosynthesis of the Universe due to which the elements with a mass of A > 11-12 may be formed. The results in the field of study of thermonuclear proton-capture reaction on 10B at ultralow, i.e., astrophysical energies will be presented further. The possibility of description of the experimental data for the astrophysical S-factor of the proton radiative capture on 16O to the ground state (GS) of 17F was considered in the frame of the MPCM with FS and classification of the states according to Young tableaux. It was shown that on the basis of the E1 transitions from the states of p16O scattering to the GS of 17F in the p16O channel generally succeed to explain the value of measured cross-sections at astrophysical energies.

  15. A Cultural Resources Inventory and Historical Evaluation of the Smoky Atmospheric Nuclear Test, Areas 8, 9, and 10, Nevada National Security Site, Nye County, Nevada

    SciTech Connect

    Jones, Robert C.; King, Maureen L.; Beck, Colleen M.; Falvey, Lauren W.; Menocal, Tatianna M.

    2014-09-01

    This report presents the results of a National Historic Preservation Act Section 106 cultural resources inventory and historical evaluation of the 1957 Smoky atmospheric test location on the Nevada National Security Site (NNSS). The Desert Research Institute (DRI) was tasked to conduct a cultural resources study of the Smoky test area as a result of a proposed undertaking by the Department of Energy Environmental Management. This undertaking involves investigating Corrective Action Unit (CAU) 550 for potential contaminants of concern as delineated in a Corrective Action Investigation Plan. CAU 550 is an area that spatially overlaps portions of the Smoky test location. Smoky, T-2c, was a 44 kt atmospheric nuclear test detonated at 5:30 am on August 31, 1957, on top of a 213.4 m (700 ft) 200 ton tower (T-2c) in Area 8 of the NNSS. Smoky was a weapons related test of the Plumbbob series (number 19) and part of the Department of Defense Exercise Desert Rock VII and VIII. The cultural resources effort involved the development of a historic context based on archival documents and engineering records, the inventory of the cultural resources in the Smoky test area and an associated military trench location in Areas 9 and 10, and an evaluation of the National Register eligibility of the cultural resources. The inventory of the Smoky test area resulted in the identification of structures, features, and artifacts related to the physical development of the test location and the post-test remains. The Smoky test area was designated historic district D104 and coincides with a historic archaeological site recorded as 26NY14794 and the military trenches designed for troop observation, site 26NY14795. Sites 26NY14794 and 26NY14795 are spatially discrete with the trenches located 4.3 km (2.7 mi) southeast of the Smoky ground zero. As a result, historic district D104 is discontiguous and in total it covers 151.4 hectares (374 acres). The Smoky test location, recorded as historic

  16. Crystal structure of (9S,10S)-10-eth-oxy-9-hy-droxy-6,6,9-trimethyl-3-pentyl-7,8,9,10-tetra-hydro-6H-benzo[c]chromen-1-yl 4-methyl-benzene-sulfonate.

    PubMed

    Gul, Waseem; Galal, Ahmed; ElSohly, Mahmoud A; Carvalho, Paulo

    2015-12-01

    In the structure of the title compound, C30H40O6S, the cyclo-hexene and heterocyclic rings are linked by a double bond. The cyclo-hexene ring has a half-chair conformation (the methyl-ene group adjacent to the hy-droxy substituent lies above the remaining atoms) and the hy-droxy and eth-oxy groups have equatorial and bis-ectional dispositions, respectively. The heterocyclic ring has an envelope conformation (with the CMe2 C atom being the flap). The dihedral angle between the aromatic rings is 53.88 (10)°. A long intra-molecular C-H⋯S inter-action is noted. In the mol-ecular packing, hy-droxy-O-H⋯O(sulfonate) hydrogen bonds lead to a helical chain along [010]. Connections between chains are of the type methyl-C-H⋯O(sulfonate) and lead to supra-molecular layers that lie parallel to (001). The studied crystal was an inversion twin.

  17. 46 CFR 9.10 - Waiting time.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Waiting time. 9.10 Section 9.10 Shipping COAST GUARD... § 9.10 Waiting time. The same construction should be given the act when charging for waiting time as... for duty the waiting time amounts to at least one hour....

  18. 46 CFR 9.10 - Waiting time.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Waiting time. 9.10 Section 9.10 Shipping COAST GUARD... § 9.10 Waiting time. The same construction should be given the act when charging for waiting time as... for duty the waiting time amounts to at least one hour....

  19. 46 CFR 9.10 - Waiting time.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Waiting time. 9.10 Section 9.10 Shipping COAST GUARD... § 9.10 Waiting time. The same construction should be given the act when charging for waiting time as... for duty the waiting time amounts to at least one hour....

  20. 46 CFR 9.10 - Waiting time.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Waiting time. 9.10 Section 9.10 Shipping COAST GUARD... § 9.10 Waiting time. The same construction should be given the act when charging for waiting time as... for duty the waiting time amounts to at least one hour....

  1. 9 CFR 104.8 - Illegal shipments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Illegal shipments. 104.8 Section 104.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS PERMITS FOR BIOLOGICAL PRODUCTS §...

  2. 9 CFR 104.8 - Illegal shipments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Illegal shipments. 104.8 Section 104.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS PERMITS FOR BIOLOGICAL PRODUCTS §...

  3. 9 CFR 104.8 - Illegal shipments.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Illegal shipments. 104.8 Section 104.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS PERMITS FOR BIOLOGICAL PRODUCTS §...

  4. 9 CFR 355.8 - Official number.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Official number. 355.8 Section 355.8 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... CERTIFICATION CERTIFIED PRODUCTS FOR DOGS, CATS, AND OTHER CARNIVORA; INSPECTION, CERTIFICATION,...

  5. 9 CFR 355.8 - Official number.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Official number. 355.8 Section 355.8 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... CERTIFICATION CERTIFIED PRODUCTS FOR DOGS, CATS, AND OTHER CARNIVORA; INSPECTION, CERTIFICATION,...

  6. 9 CFR 355.8 - Official number.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Official number. 355.8 Section 355.8 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... CERTIFICATION CERTIFIED PRODUCTS FOR DOGS, CATS, AND OTHER CARNIVORA; INSPECTION, CERTIFICATION,...

  7. 9 CFR 355.8 - Official number.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Official number. 355.8 Section 355.8 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... CERTIFICATION CERTIFIED PRODUCTS FOR DOGS, CATS, AND OTHER CARNIVORA; INSPECTION, CERTIFICATION,...

  8. 9 CFR 355.8 - Official number.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Official number. 355.8 Section 355.8 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... CERTIFICATION CERTIFIED PRODUCTS FOR DOGS, CATS, AND OTHER CARNIVORA; INSPECTION, CERTIFICATION,...

  9. 9 CFR 104.8 - Illegal shipments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Illegal shipments. 104.8 Section 104.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS PERMITS FOR BIOLOGICAL PRODUCTS §...

  10. 9 CFR 104.8 - Illegal shipments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Illegal shipments. 104.8 Section 104.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS PERMITS FOR BIOLOGICAL PRODUCTS §...

  11. Revision, uptake and coding issues related to the open access Orchard Sports Injury Classification System (OSICS) versions 8, 9 and 10.1

    PubMed Central

    Orchard, John; Rae, Katherine; Brooks, John; Hägglund, Martin; Til, Lluis; Wales, David; Wood, Tim

    2010-01-01

    The Orchard Sports Injury Classification System (OSICS) is one of the world’s most commonly used systems for coding injury diagnoses in sports injury surveillance systems. Its major strengths are that it has wide usage, has codes specific to sports medicine and that it is free to use. Literature searches and stakeholder consultations were made to assess the uptake of OSICS and to develop new versions. OSICS was commonly used in the sports of football (soccer), Australian football, rugby union, cricket and tennis. It is referenced in international papers in three sports and used in four commercially available computerised injury management systems. Suggested injury categories for the major sports are presented. New versions OSICS 9 (three digit codes) and OSICS 10.1 (four digit codes) are presented. OSICS is a potentially helpful component of a comprehensive sports injury surveillance system, but many other components are required. Choices made in developing these components should ideally be agreed upon by groups of researchers in consensus statements. PMID:24198559

  12. AE8/AP8 Implementations in AE9/AP9, IRBEM, and SPENVIS

    DTIC Science & Technology

    2014-02-18

    radiation belt model, SHIELDOSE, AE8/AP8 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES 19a. NAME OF RESPONSIBLE...a wide range of locations within the radiation belts . The new AE9/AP9 model application includes the ability to query the legacy AE8 and AP8 models...trapped particle fluxes with the NASA models AP-8 and AE-8, Radiat . Meas., 26, pp. 947-952. International Association of Geomagnetism and Aeronomy

  13. Theoretical exploration of the nanoscale host-guest interactions between [n]cycloparaphenylenes (n = 10, 8 and 9) and fullerene C₆₀: from single- to three-potential well.

    PubMed

    Yuan, Kun; Zhou, Cai-Hua; Zhu, Yuan-Cheng; Zhao, Xiang

    2015-07-28

    The nanoscale host-guest interactions between [n]cycloparaphenylene ([n]CPP; n = 10, 8 and 9) nano-ring and fullerene C60 were explored theoretically. It is found that relatively small variations in the sizes of the [n]CPP host lead to very significant changes in encapsulation property toward the fullerene C60 guest. Expectedly, one stable inclusion-configuration of [10]CPP⊃C60 and one floating-configuration of [8]CPP⊃C60 are located on the potential surfaces of the two complexes, respectively. Unexpectedly, besides a floating-configuration (F-[9]CPP⊃C60), another stable inclusion-configuration (I-[9]CPP⊃C60) is also located on the potential surface of [9]CPP⊃C60 host-guest complex. Interaction energies and natural steric analysis show that these complexes are stabilized by balancing concave-convex π-π attractive and steric repulsive host-guest interactions. In contrast, the steric repulsive energy (Es) between host and guest of I-[9]CPP⊃C60 is as high as 233.12 kJ mol(-1), which is much larger than those in other complexes. The movements of C60 guest through the cavities of [n]CPP host (n = 10, 8 and 9) are simulated by calculating the energy profile, and the results interestingly reveal that the encapsulation of C60 by [10]CPP is in the manner of a single-potential well, by [8]CPP in the manner of a double-potential well, and by [9]CPP in the special manner of a three-potential well. We predict that the movement of C60 guest through the cavity of [9]CPP host should be experimentally observable owing to the relatively low energy barrier (<50 kJ mol(-1), M06-2X/6-31G(d)). Charge population analysis shows that an obvious charge transfer between host and guest takes place during the formation of I-[9]CPP⊃C60, which is different from those during the formation of [8]CPP⊃C60, [10]CPP⊃C60 and F-[9]CPP⊃C60. Additionally, the host-guest interaction regions were detected and visualized in real space based on the electron density and reduced density

  14. Phylogenetic Analysis and Pathogenicity Assessment of Two Strains of Avian Influenza Virus Subtype H9N2 Isolated from Migratory Birds: High Homology of Internal Genes with Human H10N8 Virus

    PubMed Central

    Ye, Ge; Liang, Chai Hong; Hua, Deng Guo; Song, Lei Yong; Xiang, Yang Guo; Guang, Chen; Lan, Chen Hua; Ping, Hua Yu

    2016-01-01

    Two human-infecting avian influenza viruses (AIVs), H7N9 and H10N8, have emerged in China, which further indicate that the H9N2 subtype of AIVs, as an internal gene donor, may have an important role in the generation of new viruses with cross-species transmissibility and pathogenicity. H9N2 viruses that contain such internal genes widely exist in poultry but are rarely reported in migratory birds. In this study, two strains of the H9N2 virus were isolated from fecal samples of migratory birds in 2014: one strain from Caizi Lake in Anhui Province and one from Chen Lake in Hubei Province of China. Nucleotide sequence analysis revealed high homology of all six internal genes of these two strains with the internal genes of the human H10N8 virus in Jiangxi Province, as well as with the human H7N9 virus. Phylogenetic analysis indicated a possible origin of these two strains from poultry in South China. Both of the two viruses tested could replicated in respiratory organs of infective mice without adaption, by both strains of the H9N2 AIVs from wild birds, suggesting their potential capacity for directly infecting mammals. Our findings indicate the existence of H9N2 viruses that contain internal genes highly homologous with human H10N8 or H7N9 viruses. Wild birds can contribute to the spread of the H9N2 virus that contains the “harmful” internal gene complex, leading to gene rearrangement with other influenza viruses and to the generation of new pathogenic viruses. Therefore, strengthening AIV surveillance in wild birds can promote an understanding of the presence and prevalence of viruses and provide scientific evidence for the prevention and control of AIVs and human-infecting AIVs. PMID:26973600

  15. Phylogenetic Analysis and Pathogenicity Assessment of Two Strains of Avian Influenza Virus Subtype H9N2 Isolated from Migratory Birds: High Homology of Internal Genes with Human H10N8 Virus.

    PubMed

    Ye, Ge; Liang, Chai Hong; Hua, Deng Guo; Song, Lei Yong; Xiang, Yang Guo; Guang, Chen; Lan, Chen Hua; Ping, Hua Yu

    2016-01-01

    Two human-infecting avian influenza viruses (AIVs), H7N9 and H10N8, have emerged in China, which further indicate that the H9N2 subtype of AIVs, as an internal gene donor, may have an important role in the generation of new viruses with cross-species transmissibility and pathogenicity. H9N2 viruses that contain such internal genes widely exist in poultry but are rarely reported in migratory birds. In this study, two strains of the H9N2 virus were isolated from fecal samples of migratory birds in 2014: one strain from Caizi Lake in Anhui Province and one from Chen Lake in Hubei Province of China. Nucleotide sequence analysis revealed high homology of all six internal genes of these two strains with the internal genes of the human H10N8 virus in Jiangxi Province, as well as with the human H7N9 virus. Phylogenetic analysis indicated a possible origin of these two strains from poultry in South China. Both of the two viruses tested could replicated in respiratory organs of infective mice without adaption, by both strains of the H9N2 AIVs from wild birds, suggesting their potential capacity for directly infecting mammals. Our findings indicate the existence of H9N2 viruses that contain internal genes highly homologous with human H10N8 or H7N9 viruses. Wild birds can contribute to the spread of the H9N2 virus that contains the "harmful" internal gene complex, leading to gene rearrangement with other influenza viruses and to the generation of new pathogenic viruses. Therefore, strengthening AIV surveillance in wild birds can promote an understanding of the presence and prevalence of viruses and provide scientific evidence for the prevention and control of AIVs and human-infecting AIVs.

  16. 32 CFR 9.10 - Other.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Other. 9.10 Section 9.10 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS PROCEDURES FOR TRIALS BY MILITARY COMMISSIONS OF CERTAIN NON-UNITED STATES CITIZENS IN THE WAR AGAINST TERRORISM § 9.10 Other....

  17. 32 CFR 9.10 - Other.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Other. 9.10 Section 9.10 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS PROCEDURES FOR TRIALS BY MILITARY COMMISSIONS OF CERTAIN NON-UNITED STATES CITIZENS IN THE WAR AGAINST TERRORISM § 9.10 Other....

  18. 32 CFR 9.10 - Other.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Other. 9.10 Section 9.10 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS PROCEDURES FOR TRIALS BY MILITARY COMMISSIONS OF CERTAIN NON-UNITED STATES CITIZENS IN THE WAR AGAINST TERRORISM § 9.10 Other....

  19. Uses of monoclonial antibody 8H9

    DOEpatents

    Cheung, Nai-Kong V.

    2015-06-23

    This invention provides an antibody that binds the same antigen as that of monoclonal antibody 8H9, wherein the heavy chain CDR (Complementary Determining Region)1 comprises NYDIN, heavy chain CDR2 comprises WIFPGDGSTQY, heavy chain CDR3 comprises QTTATWFAY, and the light chain CDR1 comprises RASQSISDYLH, light chain CDR2 comprises YASQSIS, and light chain CDR3 comprises QNGHSFPLT. In another embodiment, there is provided a polypeptide that binds the same antigen as that of monoclonal antibody 8H9, wherein the polypeptide comprises NYDIN, WIFPGDGSTQY, QTTATWFAY, RASQSISDYLH, YASQSIS, and QNGHSFPLT.

  20. 1 CFR 8.9 - Form of citation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Form of citation. 8.9 Section 8.9 General... section, and the short form “CFR” may be used for “Code of Federal Regulations.” For example, “1 CFR 10.2” refers to title 1, Code of Federal Regulations, part 10, section 2....

  1. 1 CFR 8.9 - Form of citation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Form of citation. 8.9 Section 8.9 General... section, and the short form “CFR” may be used for “Code of Federal Regulations.” For example, “1 CFR 10.2” refers to title 1, Code of Federal Regulations, part 10, section 2....

  2. 8. August, 1970 PUMP BEHIND PELEG COGGESHALL HOUSE, 10 ORANGE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. August, 1970 PUMP BEHIND PELEG COGGESHALL HOUSE, 10 ORANGE STREET (MASS-1063) - Orange & Union Streets Neighborhood Study, 8-31 Orange Street, 9-21 Union Street & Stone Alley, Nantucket, Nantucket County, MA

  3. 15 CFR 8.10 - Investigations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Investigations. 8.10 Section 8.10... Compliance § 8.10 Investigations. (a) Making the investigation. The responsible Department official or his designee will make a prompt investigation whenever a compliance review, report, complaint, or any...

  4. 15 CFR 8.10 - Investigations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Investigations. 8.10 Section 8.10... Compliance § 8.10 Investigations. (a) Making the investigation. The responsible Department official or his designee will make a prompt investigation whenever a compliance review, report, complaint, or any...

  5. 15 CFR 8.10 - Investigations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Investigations. 8.10 Section 8.10... Compliance § 8.10 Investigations. (a) Making the investigation. The responsible Department official or his designee will make a prompt investigation whenever a compliance review, report, complaint, or any...

  6. 15 CFR 8.10 - Investigations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Investigations. 8.10 Section 8.10... Compliance § 8.10 Investigations. (a) Making the investigation. The responsible Department official or his designee will make a prompt investigation whenever a compliance review, report, complaint, or any...

  7. 38 CFR 8.10 - How paid.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false How paid. 8.10 Section 8.10 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS NATIONAL SERVICE LIFE INSURANCE Dividends § 8.10 How paid. (a) Except as hereinafter provided in this paragraph, a...

  8. Synthesis and structural study of 4-(2-chlorophenyl)-2-ethoxy-5,6,7,8,9,10-hexahydrocycloocta[B]pyridine-3-carbonitrile

    NASA Astrophysics Data System (ADS)

    Fathima, K. Saiadali; Vasumathi, M.; Anitha, K.

    2016-05-01

    The novel organic material C20H21ClN2O was synthesized by One-Pot synthesis method and the single crystals were grown by slow evaporation solution growth technique. The crystal structure was elucidated by subjecting the grown crystals to the single crystal x-ray diffraction analysis and was refined by full matrix least-squares method to R=0.039 for 2746 reflections. Crystal system of the grown crystal was found to be monoclinic with the space group P21/a and a=9.196(4) Å, b=13.449(4) Å, c=14.818(4) Å, β= 101.542(3)°, V=1795.6(11) Å3 and Z=4. In this crystal structure, cyclooctanone prefers to reside in a chair-boat conformation. The structure is stabilized by attractive molecular force such as CH/π interaction called hydrophobic interaction.

  9. Types of injuries among Polish soldiers and civilian staff in the 7th, 8th, 9th and 10th rotation of the Afghan stabilization mission

    PubMed Central

    Ziemba, Radosław

    2012-01-01

    Summary Background The Afghan military theatre is specifically marked by guerilla operations and massive use of IEDs (improvised explosive devices) that pose new types of threats for their victims. At the same time, the relevant literature contains only a single, fragmentary analysis on injuries suffered by soldiers serving in the Afghan mission. Material/Methods This is a review of medical reports of the Polish Military Contingent deployed within Operation Enduring Freedom, from 1 January 2010 to 31 December 2011; the analysis includes all cases of combat and non-combat injuries in terms of their causes. Results In the period under analysis, 380 Polish soldiers were reported injured; 87.1% of cases were combat and 12.9% non-combat injuries. The structure of injuries caused as a result of IED explosions was dominated by multiple limb injuries, associated most frequently with severe body cavities/spine injuries. In the case of other incidents, both combat and non-combat, the predominant consequences were single and, most commonly, less severe injuries. The average number of injuries suffered from IED attacks (3.37) was significantly higher than the number of injuries from other attacks (1.16), and higher than the number of non-combat injuries (1.43). Conclusions IED attacks pose a serious medical problem, considering their high number and the severity of injuries they cause. PMID:22367143

  10. 8 CFR 204.10 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false 204.10 Section 204.10 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRANT PETITIONS Immigrant Visa Petitions § 204.10...

  11. 8 CFR 204.10 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false 204.10 Section 204.10 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRANT PETITIONS Immigrant Visa Petitions § 204.10...

  12. 8 CFR 204.10 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false 204.10 Section 204.10 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRANT PETITIONS Immigrant Visa Petitions § 204.10...

  13. 8,9-DIHYDROXY-8,9-DIHYDRODIBENZO[A,L]PYRENE IS A POTENT MORPHOLOGICAL CELL-TRANSFORMING AGENT IN C3H10T1/2C18 MOUSE EMBRYO FIBROBLASTS IN THE ABSENCE OF DETECTABLE STABLE COVALENT DNA ADDUCTS

    EPA Science Inventory

    The comparative genotoxic effects of racemic trans-8,9dihydroxy-8,9-dihydrodibenzo[a,l]pyrene (trans- DB[a,l]P8,9-diol), the metabolic K-region dihydrodiol of dibenzo[a,l] pyrene (DB[a,l]P) (dibenzo[def,p]chrysene) and DB[a,l]P in transformable mouse embryo C3HIOT1/2C18 (C3HIOT1/...

  14. 10 CFR 605.8 - Solicitation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Solicitation. 605.8 Section 605.8 Energy DEPARTMENT OF... § 605.8 Solicitation. (a) The Catalog of Federal Domestic Assistance number for this program is 81.049, and its solicitation control number is ERFAP 10 CFR part 605. (b) An application for a new or...

  15. 10 CFR 605.8 - Solicitation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Solicitation. 605.8 Section 605.8 Energy DEPARTMENT OF... § 605.8 Solicitation. (a) The Catalog of Federal Domestic Assistance number for this program is 81.049, and its solicitation control number is ERFAP 10 CFR part 605. (b) An application for a new or...

  16. 10 CFR 605.8 - Solicitation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Solicitation. 605.8 Section 605.8 Energy DEPARTMENT OF... § 605.8 Solicitation. (a) The Catalog of Federal Domestic Assistance number for this program is 81.049, and its solicitation control number is ERFAP 10 CFR part 605. (b) An application for a new or...

  17. 10 CFR 605.8 - Solicitation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Solicitation. 605.8 Section 605.8 Energy DEPARTMENT OF... § 605.8 Solicitation. (a) The Catalog of Federal Domestic Assistance number for this program is 81.049, and its solicitation control number is ERFAP 10 CFR part 605. (b) An application for a new or...

  18. 10 CFR 61.9 - Employee protection.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Employee protection. 61.9 Section 61.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE General Provisions § 61.9 Employee protection. (a) Discrimination by a Commission licensee, an applicant for...

  19. 10 CFR 61.9 - Employee protection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Employee protection. 61.9 Section 61.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE General Provisions § 61.9 Employee protection. (a) Discrimination by a Commission licensee, an applicant for...

  20. 10 CFR 60.9 - Employee protection.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Employee protection. 60.9 Section 60.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES General Provisions § 60.9 Employee protection. (a) Discrimination by a Commission licensee, an applicant for...

  1. 10 CFR 61.9 - Employee protection.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Employee protection. 61.9 Section 61.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE General Provisions § 61.9 Employee protection. (a) Discrimination by a Commission licensee, an applicant for...

  2. 10 CFR 60.9 - Employee protection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Employee protection. 60.9 Section 60.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES General Provisions § 60.9 Employee protection. (a) Discrimination by a Commission licensee, an applicant for...

  3. 10 CFR 60.9 - Employee protection.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Employee protection. 60.9 Section 60.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES General Provisions § 60.9 Employee protection. (a) Discrimination by a Commission licensee, an applicant for...

  4. 10 CFR 60.9 - Employee protection.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Employee protection. 60.9 Section 60.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES General Provisions § 60.9 Employee protection. (a) Discrimination by a Commission licensee, an applicant for...

  5. 10 CFR 61.9 - Employee protection.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Employee protection. 61.9 Section 61.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE General Provisions § 61.9 Employee protection. (a) Discrimination by a Commission licensee, an applicant for...

  6. 10 CFR 60.9 - Employee protection.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Employee protection. 60.9 Section 60.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES General Provisions § 60.9 Employee protection. (a) Discrimination by a Commission licensee, an applicant for...

  7. 10 CFR 61.9 - Employee protection.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Employee protection. 61.9 Section 61.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE General Provisions § 61.9 Employee protection. (a) Discrimination by a Commission licensee, an applicant for...

  8. 10 CFR 52.9 - Jurisdictional limits.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Jurisdictional limits. 52.9 Section 52.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General Provisions § 52.9 Jurisdictional limits. No permit, license, standard design approval, or standard...

  9. 10 CFR 52.9 - Jurisdictional limits.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Jurisdictional limits. 52.9 Section 52.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General Provisions § 52.9 Jurisdictional limits. No permit, license, standard design approval, or standard...

  10. 10 CFR 52.9 - Jurisdictional limits.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Jurisdictional limits. 52.9 Section 52.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General Provisions § 52.9 Jurisdictional limits. No permit, license, standard design approval, or standard...

  11. 10 CFR 52.9 - Jurisdictional limits.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Jurisdictional limits. 52.9 Section 52.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General Provisions § 52.9 Jurisdictional limits. No permit, license, standard design approval, or standard...

  12. 10 CFR 9.5 - Interpretations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Interpretations. 9.5 Section 9.5 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS § 9.5 Interpretations. Except as specifically authorized by the Commission in writing, no interpretation of the meaning of the regulations in this part by an officer or employee of...

  13. 10 CFR 63.9 - Employee protection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Employee protection. 63.9 Section 63.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA General Provisions § 63.9 Employee protection. (a) Discrimination by a Commission...

  14. 10 CFR 37.9 - Interpretations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Interpretations. 37.9 Section 37.9 Energy NUCLEAR REGULATORY COMMISSION PHYSICAL PROTECTION OF CATEGORY 1 AND CATEGORY 2 QUANTITIES OF RADIOACTIVE MATERIAL General Provisions § 37.9 Interpretations. Except as specifically authorized by the Commission in...

  15. 10 CFR 63.9 - Employee protection.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Employee protection. 63.9 Section 63.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA General Provisions § 63.9 Employee protection. (a) Discrimination by a Commission...

  16. 10 CFR 63.9 - Employee protection.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Employee protection. 63.9 Section 63.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA General Provisions § 63.9 Employee protection. (a) Discrimination by a Commission...

  17. 10 CFR 63.9 - Employee protection.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Employee protection. 63.9 Section 63.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA General Provisions § 63.9 Employee protection. (a) Discrimination by a Commission...

  18. 10 CFR 63.9 - Employee protection.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Employee protection. 63.9 Section 63.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA General Provisions § 63.9 Employee protection. (a) Discrimination by a Commission...

  19. 10 CFR 820.9 - Special assistant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Special assistant. 820.9 Section 820.9 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR DOE NUCLEAR ACTIVITIES General § 820.9 Special assistant. A DOE Official may appoint a person to serve as a special assistant to assist the DOE Official in the conduct...

  20. 10 CFR 13.9 - Answer.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Answer. 13.9 Section 13.9 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.9 Answer. (a) The defendant may request a hearing by filing an answer with the reviewing official within thirty (30) days of service of the complaint. Service of...

  1. 10 CFR 9.5 - Interpretations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Interpretations. 9.5 Section 9.5 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS § 9.5 Interpretations. Except as specifically authorized by the Commission in writing, no interpretation of the meaning of the regulations in this part by an officer or employee of...

  2. 10 CFR 9.51 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Definitions. 9.51 Section 9.51 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS Privacy Act Regulations § 9.51 Definitions. As used in this subpart: (a) Individual means a citizen of the United States or an alien lawfully admitted for permanent residence. (b) The...

  3. 10 CFR 9.5 - Interpretations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Interpretations. 9.5 Section 9.5 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS § 9.5 Interpretations. Except as specifically authorized by the Commission in writing, no interpretation of the meaning of the regulations in this part by an officer or employee of...

  4. 10 CFR 9.5 - Interpretations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Interpretations. 9.5 Section 9.5 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS § 9.5 Interpretations. Except as specifically authorized by the Commission in writing, no interpretation of the meaning of the regulations in this part by an officer or employee of...

  5. 10 CFR 9.5 - Interpretations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Interpretations. 9.5 Section 9.5 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS § 9.5 Interpretations. Except as specifically authorized by the Commission in writing, no interpretation of the meaning of the regulations in this part by an officer or employee of...

  6. 10 CFR 9.51 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Definitions. 9.51 Section 9.51 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS Privacy Act Regulations § 9.51 Definitions. As used in this subpart: (a) Individual... education, financial transactions, medical history, employment history or criminal history, and...

  7. 10 CFR 9.51 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Definitions. 9.51 Section 9.51 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS Privacy Act Regulations § 9.51 Definitions. As used in this subpart: (a) Individual... education, financial transactions, medical history, employment history or criminal history, and...

  8. 10 CFR 9.51 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Definitions. 9.51 Section 9.51 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS Privacy Act Regulations § 9.51 Definitions. As used in this subpart: (a) Individual... education, financial transactions, medical history, employment history or criminal history, and...

  9. 10 CFR 9.51 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Definitions. 9.51 Section 9.51 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS Privacy Act Regulations § 9.51 Definitions. As used in this subpart: (a) Individual... education, financial transactions, medical history, employment history or criminal history, and...

  10. 10 CFR 904.9 - Excess capacity.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Excess capacity. 904.9 Section 904.9 Energy DEPARTMENT OF ENERGY GENERAL REGULATIONS FOR THE CHARGES FOR THE SALE OF POWER FROM THE BOULDER CANYON PROJECT Power Marketing § 904.9 Excess capacity. (a) If the Uprating Program results in Excess Capacity, Western shall...

  11. 10 CFR 904.9 - Excess capacity.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Excess capacity. 904.9 Section 904.9 Energy DEPARTMENT OF ENERGY GENERAL REGULATIONS FOR THE CHARGES FOR THE SALE OF POWER FROM THE BOULDER CANYON PROJECT Power Marketing § 904.9 Excess capacity. (a) If the Uprating Program results in Excess Capacity, Western shall...

  12. 10 CFR 904.9 - Excess capacity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Excess capacity. 904.9 Section 904.9 Energy DEPARTMENT OF ENERGY GENERAL REGULATIONS FOR THE CHARGES FOR THE SALE OF POWER FROM THE BOULDER CANYON PROJECT Power Marketing § 904.9 Excess capacity. (a) If the Uprating Program results in Excess Capacity, Western shall...

  13. 10 CFR 904.9 - Excess capacity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Excess capacity. 904.9 Section 904.9 Energy DEPARTMENT OF ENERGY GENERAL REGULATIONS FOR THE CHARGES FOR THE SALE OF POWER FROM THE BOULDER CANYON PROJECT Power Marketing § 904.9 Excess capacity. (a) If the Uprating Program results in Excess Capacity, Western shall...

  14. 10 CFR 71.9 - Employee protection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Employee protection. 71.9 Section 71.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PACKAGING AND TRANSPORTATION OF RADIOACTIVE MATERIAL General Provisions § 71.9 Employee protection. (a) Discrimination by a Commission licensee, certificate holder,...

  15. 10 CFR 26.9 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Specific exemptions. 26.9 Section 26.9 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.9 Specific exemptions. Upon application of any interested person or on its own initiative, the Commission may grant such exemptions...

  16. 10 CFR 26.9 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Specific exemptions. 26.9 Section 26.9 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.9 Specific exemptions. Upon application of any interested person or on its own initiative, the Commission may grant such exemptions...

  17. 10 CFR 26.9 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Specific exemptions. 26.9 Section 26.9 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.9 Specific exemptions. Upon application of any interested person or on its own initiative, the Commission may grant such exemptions...

  18. 10 CFR 26.9 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Specific exemptions. 26.9 Section 26.9 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.9 Specific exemptions. Upon application of any interested person or on its own initiative, the Commission may grant such exemptions...

  19. 10 CFR 26.9 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Specific exemptions. 26.9 Section 26.9 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.9 Specific exemptions. Upon application of any interested person or on its own initiative, the Commission may grant such exemptions...

  20. 10 CFR 52.9 - Jurisdictional limits.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Jurisdictional limits. 52.9 Section 52.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General Provisions § 52.9 Jurisdictional limits. No permit, license, standard design approval, or standard...

  1. 10 CFR 904.9 - Excess capacity.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Excess capacity. 904.9 Section 904.9 Energy DEPARTMENT OF... Marketing § 904.9 Excess capacity. (a) If the Uprating Program results in Excess Capacity, Western shall be entitled to such Excess Capacity to integrate the operation of the Boulder City Area Projects and...

  2. 10 CFR 9.35 - Duplication fees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Duplication fees. 9.35 Section 9.35 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS Freedom of Information Act Regulations § 9.35 Duplication fees. (a)(1...″ reduced). Pages 11″ × 17″ are $0.30 per page. Pages larger than 11″ × 17″, including engineering...

  3. 10 CFR 9.90 - Violations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Violations. 9.90 Section 9.90 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS Privacy Act Regulations Enforcement § 9.90 Violations. (a) An injunction or other... results in an adverse determination or has an adverse effect on an individual. Court costs and...

  4. 10 CFR 11.9 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Specific exemptions. 11.9 Section 11.9 Energy NUCLEAR... SPECIAL NUCLEAR MATERIAL General Provisions § 11.9 Specific exemptions. The Commission may, upon... granted only if they are authorized by law and will not constitute an undue risk to the common defense...

  5. 17 CFR 9.10 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false 9.10 Section 9.10 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION RULES RELATING TO REVIEW OF EXCHANGE DISCIPLINARY, ACCESS DENIAL OR OTHER ADVERSE ACTIONS Notice and Effective Date of Disciplinary Action or...

  6. 38 CFR 9.10 - Health standards.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false Health standards. 9.10... LIFE INSURANCE AND VETERANS' GROUP LIFE INSURANCE § 9.10 Health standards. (a) For the purpose of... criteria used by the insurer in determining good health for persons applying to it for life insurance...

  7. 38 CFR 9.10 - Health standards.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2012-07-01 2012-07-01 false Health standards. 9.10... LIFE INSURANCE AND VETERANS' GROUP LIFE INSURANCE § 9.10 Health standards. (a) For the purpose of... criteria used by the insurer in determining good health for persons applying to it for life insurance...

  8. 38 CFR 9.10 - Health standards.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Health standards. 9.10... LIFE INSURANCE AND VETERANS' GROUP LIFE INSURANCE § 9.10 Health standards. (a) For the purpose of... criteria used by the insurer in determining good health for persons applying to it for life insurance...

  9. 38 CFR 9.10 - Health standards.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Health standards. 9.10... LIFE INSURANCE AND VETERANS' GROUP LIFE INSURANCE § 9.10 Health standards. (a) For the purpose of... criteria used by the insurer in determining good health for persons applying to it for life insurance...

  10. 38 CFR 9.10 - Health standards.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false Health standards. 9.10... LIFE INSURANCE AND VETERANS' GROUP LIFE INSURANCE § 9.10 Health standards. (a) For the purpose of... criteria used by the insurer in determining good health for persons applying to it for life insurance...

  11. 9 CFR 592.10 - Authority.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Authority. 592.10 Section 592.10 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION VOLUNTARY INSPECTION OF EGG PRODUCTS Administration § 592.10 Authority. The Administrator...

  12. 10 CFR 820.8 - Evidentiary matters.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Evidentiary matters. 820.8 Section 820.8 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR DOE NUCLEAR ACTIVITIES General § 820.8 Evidentiary matters. (a... matter related to a DOE nuclear activity or for any decision required by this part. A DOE Official...

  13. 10 CFR 820.8 - Evidentiary matters.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Evidentiary matters. 820.8 Section 820.8 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR DOE NUCLEAR ACTIVITIES General § 820.8 Evidentiary matters. (a... matter related to a DOE nuclear activity or for any decision required by this part. A DOE Official...

  14. 10 CFR 820.8 - Evidentiary matters.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Evidentiary matters. 820.8 Section 820.8 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR DOE NUCLEAR ACTIVITIES General § 820.8 Evidentiary matters. (a... matter related to a DOE nuclear activity or for any decision required by this part. A DOE Official...

  15. 10 CFR 820.8 - Evidentiary matters.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Evidentiary matters. 820.8 Section 820.8 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR DOE NUCLEAR ACTIVITIES General § 820.8 Evidentiary matters. (a... matter related to a DOE nuclear activity or for any decision required by this part. A DOE Official...

  16. 10 CFR 820.8 - Evidentiary matters.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Evidentiary matters. 820.8 Section 820.8 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR DOE NUCLEAR ACTIVITIES General § 820.8 Evidentiary matters. (a... matter related to a DOE nuclear activity or for any decision required by this part. A DOE Official...

  17. 10 CFR 824.8 - Hearing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Hearing. 824.8 Section 824.8 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY VIOLATIONS § 824.8 Hearing. (a) Any person who receives a final notice of violation under § 824.7 may request a...

  18. 10 CFR 216.8 - Communications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Communications. 216.8 Section 216.8 Energy DEPARTMENT OF ENERGY OIL MATERIALS ALLOCATION AND PRIORITY PERFORMANCE UNDER CONTRACTS OR ORDERS TO MAXIMIZE DOMESTIC ENERGY SUPPLIES § 216.8 Communications. All written communications concerning these regulations shall...

  19. 10 CFR 140.8 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Specific exemptions. 140.8 Section 140.8 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) FINANCIAL PROTECTION REQUIREMENTS AND INDEMNITY AGREEMENTS General Provisions § 140.8 Specific exemptions. The Commission may, upon application of any interested person or...

  20. 10 CFR 602.8 - Application requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Application requirements. 602.8 Section 602.8 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS EPIDEMIOLOGY AND OTHER HEALTH STUDIES FINANCIAL ASSISTANCE PROGRAM § 602.8 Application requirements. (a) An original and seven copies of the application...

  1. 10 CFR 780.8 - Security.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Security. 780.8 Section 780.8 Energy DEPARTMENT OF ENERGY PATENT COMPENSATION BOARD REGULATIONS General Provisions § 780.8 Security. In any proceeding under this... the Act to assure compliance with Department security regulations and the common defense....

  2. 10 CFR 780.8 - Security.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Security. 780.8 Section 780.8 Energy DEPARTMENT OF ENERGY PATENT COMPENSATION BOARD REGULATIONS General Provisions § 780.8 Security. In any proceeding under this... the Act to assure compliance with Department security regulations and the common defense....

  3. 10 CFR 780.8 - Security.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Security. 780.8 Section 780.8 Energy DEPARTMENT OF ENERGY PATENT COMPENSATION BOARD REGULATIONS General Provisions § 780.8 Security. In any proceeding under this... the Act to assure compliance with Department security regulations and the common defense....

  4. 10 CFR 780.8 - Security.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Security. 780.8 Section 780.8 Energy DEPARTMENT OF ENERGY PATENT COMPENSATION BOARD REGULATIONS General Provisions § 780.8 Security. In any proceeding under this... the Act to assure compliance with Department security regulations and the common defense....

  5. 10 CFR 780.8 - Security.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Security. 780.8 Section 780.8 Energy DEPARTMENT OF ENERGY PATENT COMPENSATION BOARD REGULATIONS General Provisions § 780.8 Security. In any proceeding under this... the Act to assure compliance with Department security regulations and the common defense....

  6. 10 CFR 824.8 - Hearing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Hearing. 824.8 Section 824.8 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY VIOLATIONS § 824.8 Hearing. (a) Any person who receives a final notice of violation under § 824.7 may request a...

  7. 10 CFR 824.8 - Hearing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Hearing. 824.8 Section 824.8 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY VIOLATIONS § 824.8 Hearing. (a) Any person who receives a final notice of violation under § 824.7 may request a...

  8. 10 CFR 824.8 - Hearing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Hearing. 824.8 Section 824.8 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY VIOLATIONS § 824.8 Hearing. (a) Any person who receives a final notice of violation under § 824.7 may request a...

  9. 10 CFR 824.8 - Hearing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Hearing. 824.8 Section 824.8 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY VIOLATIONS § 824.8 Hearing. (a) Any person who receives a final notice of violation under § 824.7 may request a...

  10. 10 CFR 71.8 - Deliberate misconduct.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Deliberate misconduct. 71.8 Section 71.8 Energy NUCLEAR... § 71.8 Deliberate misconduct. (a) This section applies to any— (1) Licensee; (2) Certificate holder; (3... deliberate misconduct that causes or would have caused, if not detected, a licensee, certificate...

  11. 10 CFR 1045.8 - Procedural exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Procedural exemptions. 1045.8 Section 1045.8 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NUCLEAR CLASSIFICATION AND DECLASSIFICATION Program Management of the Restricted Data and Formerly Restricted Data Classification System § 1045.8 Procedural...

  12. 10 CFR 1045.8 - Procedural exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Procedural exemptions. 1045.8 Section 1045.8 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NUCLEAR CLASSIFICATION AND DECLASSIFICATION Program Management of the Restricted Data and Formerly Restricted Data Classification System § 1045.8 Procedural...

  13. 10 CFR 1045.8 - Procedural exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Procedural exemptions. 1045.8 Section 1045.8 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NUCLEAR CLASSIFICATION AND DECLASSIFICATION Program Management of the Restricted Data and Formerly Restricted Data Classification System § 1045.8 Procedural...

  14. 10 CFR 1045.8 - Procedural exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Procedural exemptions. 1045.8 Section 1045.8 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NUCLEAR CLASSIFICATION AND DECLASSIFICATION Program Management of the Restricted Data and Formerly Restricted Data Classification System § 1045.8 Procedural...

  15. 10 CFR 1045.8 - Procedural exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Procedural exemptions. 1045.8 Section 1045.8 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NUCLEAR CLASSIFICATION AND DECLASSIFICATION Program Management of the Restricted Data and Formerly Restricted Data Classification System § 1045.8 Procedural...

  16. 10 CFR 216.8 - Communications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Communications. 216.8 Section 216.8 Energy DEPARTMENT OF ENERGY OIL MATERIALS ALLOCATION AND PRIORITY PERFORMANCE UNDER CONTRACTS OR ORDERS TO MAXIMIZE DOMESTIC ENERGY SUPPLIES § 216.8 Communications. All written communications concerning these regulations shall...

  17. 10 CFR 1706.8 - Waiver.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Waiver. 1706.8 Section 1706.8 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD ORGANIZATIONAL AND CONSULTANT CONFLICTS OF INTERESTS § 1706.8 Waiver. (a) Waiver of OCIs. The need for a waiver of any OCI in connection with the award or continuation of...

  18. 10 CFR 1706.8 - Waiver.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Waiver. 1706.8 Section 1706.8 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD ORGANIZATIONAL AND CONSULTANT CONFLICTS OF INTERESTS § 1706.8 Waiver. (a) Waiver of OCIs. The need for a waiver of any OCI in connection with the award or continuation of...

  19. 10 CFR 1706.8 - Waiver.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Waiver. 1706.8 Section 1706.8 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD ORGANIZATIONAL AND CONSULTANT CONFLICTS OF INTERESTS § 1706.8 Waiver. (a) Waiver of OCIs. The need for a waiver of any OCI in connection with the award or continuation of...

  20. 10 CFR 1706.8 - Waiver.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Waiver. 1706.8 Section 1706.8 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD ORGANIZATIONAL AND CONSULTANT CONFLICTS OF INTERESTS § 1706.8 Waiver. (a) Waiver of OCIs. The need for a waiver of any OCI in connection with the award or continuation of...

  1. Photocopy of drawing (this photograph is an 8' x 10' ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing (this photograph is an 8' x 10' copy of an 8' x 10' negative; 1941 original architectural drawing located at Building No. 458, NAS Pensacola, Florida) Building No. 18 Photographic School, ventilation, suspended ceiling plan and sections, sheet 6 of 9 - U.S. Naval Air Station, Marine Barracks, 232 East Avenue, Pensacola, Escambia County, FL

  2. 10 CFR 824.9 - Hearing Counsel.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Hearing Counsel. 824.9 Section 824.9 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY... consistent with the objectives of the Act and DOE security requirements....

  3. 10 CFR 9.3 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Definitions. 9.3 Section 9.3 Energy NUCLEAR REGULATORY... the Nuclear Regulatory Commission, established by the Energy Reorganization Act of 1974. NRC personnel... members or a quorum thereof sitting as a body, as provided by section 201 of the Energy Reorganization...

  4. 10 CFR 9.6 - Communications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Communications. 9.6 Section 9.6 Energy NUCLEAR REGULATORY... the NRC by mail addressed to the U.S. Nuclear Regulatory Commission, Washington, DC 20555-0001; by.... Nuclear Regulatory Commission, Washington, DC 20555-0001.The guidance discusses, among other topics,...

  5. 10 CFR 9.6 - Communications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Communications. 9.6 Section 9.6 Energy NUCLEAR REGULATORY... the NRC by mail addressed to the U.S. Nuclear Regulatory Commission, Washington, DC 20555-0001; by.... Nuclear Regulatory Commission, Washington, DC 20555-0001. The guidance discusses, among other topics,...

  6. 10 CFR 9.6 - Communications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Communications. 9.6 Section 9.6 Energy NUCLEAR REGULATORY... the NRC by mail addressed to the U.S. Nuclear Regulatory Commission, Washington, DC 20555-0001; by.... Nuclear Regulatory Commission, Washington, DC 20555-0001. The guidance discusses, among other topics,...

  7. 10 CFR 9.3 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Definitions. 9.3 Section 9.3 Energy NUCLEAR REGULATORY... the Nuclear Regulatory Commission, established by the Energy Reorganization Act of 1974. NRC personnel... members or a quorum thereof sitting as a body, as provided by section 201 of the Energy Reorganization...

  8. 10 CFR 9.3 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Definitions. 9.3 Section 9.3 Energy NUCLEAR REGULATORY... the Nuclear Regulatory Commission, established by the Energy Reorganization Act of 1974. NRC personnel... members or a quorum thereof sitting as a body, as provided by section 201 of the Energy Reorganization...

  9. 10 CFR 9.3 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Definitions. 9.3 Section 9.3 Energy NUCLEAR REGULATORY... the Nuclear Regulatory Commission, established by the Energy Reorganization Act of 1974. NRC personnel... members or a quorum thereof sitting as a body, as provided by section 201 of the Energy Reorganization...

  10. 10 CFR 9.6 - Communications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Communications. 9.6 Section 9.6 Energy NUCLEAR REGULATORY... the NRC by mail addressed to the U.S. Nuclear Regulatory Commission, Washington, DC 20555-0001; by.... Nuclear Regulatory Commission, Washington, DC 20555-0001. The guidance discusses, among other topics,...

  11. 10 CFR 9.3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Definitions. 9.3 Section 9.3 Energy NUCLEAR REGULATORY... the Nuclear Regulatory Commission, established by the Energy Reorganization Act of 1974. NRC personnel... members or a quorum thereof sitting as a body, as provided by section 201 of the Energy Reorganization...

  12. 10 CFR 9.6 - Communications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Communications. 9.6 Section 9.6 Energy NUCLEAR REGULATORY... the NRC by mail addressed to the U.S. Nuclear Regulatory Commission, Washington, DC 20555-0001; by.... Nuclear Regulatory Commission, Washington, DC 20555-0001. The guidance discusses, among other topics,...

  13. 10 CFR 824.9 - Hearing Counsel.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Hearing Counsel. 824.9 Section 824.9 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY... consistent with the objectives of the Act and DOE security requirements....

  14. 10 CFR 824.9 - Hearing Counsel.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Hearing Counsel. 824.9 Section 824.9 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY... consistent with the objectives of the Act and DOE security requirements....

  15. 10 CFR 824.9 - Hearing Counsel.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Hearing Counsel. 824.9 Section 824.9 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY... consistent with the objectives of the Act and DOE security requirements....

  16. 10 CFR 824.9 - Hearing Counsel.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Hearing Counsel. 824.9 Section 824.9 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY... consistent with the objectives of the Act and DOE security requirements....

  17. Atmospheric reactions of 9,10-anthraquinone.

    PubMed

    Miet, Killian; Albinet, Alexandre; Budzinski, Hélène; Villenave, Eric

    2014-07-01

    The probably carcinogenic compound 9,10-anthraquinone is mainly existing in the atmosphere in the particulate phase and is often detected and measured among other oxygenated PAHs in atmospheric samples. Its fate, once released or formed in the atmosphere, still remains unknown. In this work, heterogeneous chemical oxidation processes of 9,10-anthraquinone were investigated with ozone (O3), nitrogen dioxide (NO2) and hydroxyl radical (OH). The study of 9,10-anthraquinone adsorbed on silica particles showed no reactivity with O3 and NO2. On the other hand, the reaction with OH radicals was observed and led to the formation of 1-hydroxy-9,10-anthraquinone, another oxidation product recognized as possibly carcinogenic to humans. This study showed that reactions with ozone and nitrogen dioxide are unlikely to contribute to atmospheric degradation of 9,10-anthraquinone, whereas reactions with OH radicals could be involved in 9,10-anthraquinone degradation processes, even if such reaction is probably very slow under ambient conditions.

  18. 8 CFR 1003.10 - Immigration judges.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Immigration judges. 1003.10 Section 1003.10 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE GENERAL PROVISIONS EXECUTIVE OFFICE FOR IMMIGRATION REVIEW Office of the Chief Immigration Judge § 1003.10 Immigration...

  19. 8 CFR 1003.10 - Immigration judges.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Immigration judges. 1003.10 Section 1003.10 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE GENERAL PROVISIONS EXECUTIVE OFFICE FOR IMMIGRATION REVIEW Office of the Chief Immigration Judge § 1003.10 Immigration...

  20. 8 CFR 1003.10 - Immigration judges.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Immigration judges. 1003.10 Section 1003.10 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE GENERAL PROVISIONS EXECUTIVE OFFICE FOR IMMIGRATION REVIEW Office of the Chief Immigration Judge § 1003.10 Immigration...

  1. 8 CFR 1003.10 - Immigration judges.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Immigration judges. 1003.10 Section 1003.10 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE GENERAL PROVISIONS EXECUTIVE OFFICE FOR IMMIGRATION REVIEW Office of the Chief Immigration Judge § 1003.10 Immigration...

  2. 8 CFR 1003.10 - Immigration judges.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Immigration judges. 1003.10 Section 1003.10 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE GENERAL PROVISIONS EXECUTIVE OFFICE FOR IMMIGRATION REVIEW Office of the Chief Immigration Judge § 1003.10 Immigration...

  3. 8 CFR 245a.10 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Definitions. 245a.10 Section 245a.10 Aliens... IMMIGRATION AND NATIONALITY ACT Legal Immigration Family Equity (LIFE) Act Legalization Provisions § 245a.10 Definitions. In this Subpart B, the terms: Eligible alien means an alien (including a spouse or child...

  4. 8 CFR 245a.10 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Definitions. 245a.10 Section 245a.10 Aliens... AND NATIONALITY ACT Legal Immigration Family Equity (LIFE) Act Legalization Provisions § 245a.10 Definitions. In this Subpart B, the terms: Eligible alien means an alien (including a spouse or child...

  5. 8 CFR 245a.10 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Definitions. 245a.10 Section 245a.10 Aliens... AND NATIONALITY ACT Legal Immigration Family Equity (LIFE) Act Legalization Provisions § 245a.10 Definitions. In this Subpart B, the terms: Eligible alien means an alien (including a spouse or child...

  6. 8 CFR 245a.10 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Definitions. 245a.10 Section 245a.10 Aliens... AND NATIONALITY ACT Legal Immigration Family Equity (LIFE) Act Legalization Provisions § 245a.10 Definitions. In this Subpart B, the terms: Eligible alien means an alien (including a spouse or child...

  7. Multilayered structure based on poly(N,N-dimethyl-acrylamide-co-3,9-divinyl-2,4,8,10-tetraoxaspiro (5.5) undecane) prepared in a multiphase gelation process.

    PubMed

    Chiriac, Aurica P; Nita, Loredana E; Nistor, Manuela T; Tartau, Liliana

    2013-11-01

    The study is devoted to the preparation of a multi-membrane gel system based on poly(N,N-dimethyl-acrylamide-co-3,9-divinyl-2,4,8,10-tetraoxaspiro (5.5) undecane) copolymer. The complex supra-structure was realized by layer by layer deposition technique, from the gel-core to the periphery by crosslinking poly(N,N-dimethyl-acrylamide-co-3,9-divinyl-2,4,8,10-tetraoxaspiro (5.5) undecane) (P(DMA-co-U)) with N,N'-methylene-bis-acrylamide and using as well β-cyclodextrin with double purpose as compound for constructing further the edge of the interfacial supramolecular assemblies and to improve the host-guest complexation of further bioactive compounds. Basic copolymer has dual thermo- and pH sensitive character. The multi-membrane 'onion-like' gel system was tested as matrix for embedding Norfloxacin. Hematologic, biochemical, immunologic studies used to determine the biocompatibility of multi-membrane gel structures loaded with drug that directly contact living tissue provided a reasonable assessment of safety as implants. Histopathologic exams did not reveal any disturbances of the normal liver architecture in animals with multi-membrane gel system containing Norfloxacin compared to control group with sterile cotton pellets implant. Good biocompatibility for the implants based on multi-membrane gel structures loaded with drug were achieved from the in vivo tests these suggesting that biomaterials may be suitable for in vivo use as a local drug delivery system.

  8. Indomethacin-loaded polymer nanocarriers based on poly(2-hydroxyethyl methacrylate-co-3,9-divinyl-2,4,8,10-tetraoxaspiro (5.5) undecane): preparation, in vitro and in vivo evaluation.

    PubMed

    Nita, Loredana E; Chiriac, Aurica P; Nistor, Manuela T; Tartau, Liliana

    2012-05-01

    The study is focused on the development of copolymers based on poly(2-hydroxyethyl methacrylate-co-3,9-divinyl-2,4,8,10-tetraoxaspiro [5.5]-undecane). The macromolecular compounds were synthesized by dispersion polymerization in the presence of the radical initiator 4,4'-azobis(cyanopentanoic acid) and using sodium lauryl sulfate as tensioactive compound and poly(aspartic acid) (PAS) as protective colloid. PAS presents biocompatibility and biodegradability, and assures the increase of the absorbent character for the new synthesized network, and also, can supplement the hydrogen bonds contributing to the stability of the achieved complexes. The prepared polymeric networks were characterized by FTIR, SEM, and thermogravimetric analyses. The dependence on the pH of the swelling degree equilibrium was also evaluated correlated also with different temperature values. The poly(2-hydroxyethyl methacrylate-co-3,9-divinyl-2,4,8,10-tetraoxaspiro [5.5]-undecane) copolymers were evaluated as matrix for indomethacin (INN) as model drug loaded onto these polymeric networks. The evaluation of the homogeneity distribution of the INN drug in polymeric network was made by near infrared chemical imaging (NIR-CI) and correspondingly statistical analysis. The pharmacokinetic profile was achieved performing the in vitro release of the INN drug from the polymeric network. The data resulted from the in vivo experimental studies, respectively the biocompatibility tests, somatic nociceptive experimental model (Tail flick test) and visceral nociceptive experimental model (Writhing test)-are also reported in the study.

  9. 9 CFR 592.10 - Authority.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Authority. 592.10 Section 592.10 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS... this part. The Food Safety Inspection Service and its officers and employees shall not be liable...

  10. 9 CFR 592.10 - Authority.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Authority. 592.10 Section 592.10 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS... this part. The Food Safety Inspection Service and its officers and employees shall not be liable...

  11. 9 CFR 592.10 - Authority.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Authority. 592.10 Section 592.10 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS... this part. The Food Safety Inspection Service and its officers and employees shall not be liable...

  12. 9 CFR 592.10 - Authority.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Authority. 592.10 Section 592.10 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS... this part. The Food Safety Inspection Service and its officers and employees shall not be liable...

  13. 9 CFR 590.10 - Authority.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Authority. 590.10 Section 590.10 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS... permit experimentation so that new procedures, equipment, and processing techniques may be tested...

  14. 9 CFR 146.10 - Supervision.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Supervision. 146.10 Section 146.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... authorize qualified persons as State Inspectors to perform the selecting and testing of participating...

  15. 9 CFR 146.10 - Supervision.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Supervision. 146.10 Section 146.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... authorize qualified persons as State Inspectors to perform the selecting and testing of participating...

  16. 9 CFR 49.10 - Stipulations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Stipulations. 49.10 Section 49.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE COOPERATIVE CONTROL AND ERADICATION OF LIVESTOCK OR POULTRY DISEASES RULES OF PRACTICE GOVERNING...

  17. 9 CFR 49.10 - Stipulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Stipulations. 49.10 Section 49.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE COOPERATIVE CONTROL AND ERADICATION OF LIVESTOCK OR POULTRY DISEASES RULES OF PRACTICE GOVERNING...

  18. 9 CFR 590.10 - Authority.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Authority. 590.10 Section 590.10 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS... permit experimentation so that new procedures, equipment, and processing techniques may be tested...

  19. 9 CFR 167.10 - Stipulations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Stipulations. 167.10 Section 167.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE SWINE HEALTH PROTECTION RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE SWINE HEALTH PROTECTION...

  20. 9 CFR 167.10 - Stipulations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Stipulations. 167.10 Section 167.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE SWINE HEALTH PROTECTION RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE SWINE HEALTH PROTECTION...

  1. 9 CFR 167.10 - Stipulations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Stipulations. 167.10 Section 167.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE SWINE HEALTH PROTECTION RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE SWINE HEALTH PROTECTION...

  2. 9 CFR 167.10 - Stipulations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Stipulations. 167.10 Section 167.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE SWINE HEALTH PROTECTION RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE SWINE HEALTH PROTECTION...

  3. 9 CFR 167.10 - Stipulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Stipulations. 167.10 Section 167.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE SWINE HEALTH PROTECTION RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE SWINE HEALTH PROTECTION...

  4. 9 CFR 590.10 - Authority.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Authority. 590.10 Section 590.10 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS... permit experimentation so that new procedures, equipment, and processing techniques may be tested...

  5. 9 CFR 590.10 - Authority.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Authority. 590.10 Section 590.10 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS... permit experimentation so that new procedures, equipment, and processing techniques may be tested...

  6. 9 CFR 590.10 - Authority.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Authority. 590.10 Section 590.10 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS... permit experimentation so that new procedures, equipment, and processing techniques may be tested...

  7. 9 CFR 12.10 - Stipulations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Stipulations. 12.10 Section 12.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE HORSE PROTECTION ACT Supplemental Rules...

  8. 9 CFR 12.10 - Stipulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Stipulations. 12.10 Section 12.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE HORSE PROTECTION ACT Supplemental Rules...

  9. 9 CFR 12.10 - Stipulations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Stipulations. 12.10 Section 12.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE HORSE PROTECTION ACT Supplemental Rules...

  10. 9 CFR 12.10 - Stipulations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Stipulations. 12.10 Section 12.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE HORSE PROTECTION ACT Supplemental Rules...

  11. 9 CFR 12.10 - Stipulations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Stipulations. 12.10 Section 12.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE HORSE PROTECTION ACT Supplemental Rules...

  12. S100A8/A9 and S100A9 reduce acute lung injury.

    PubMed

    Hiroshima, Yuka; Hsu, Kenneth; Tedla, Nicodemus; Wong, Sze Wing; Chow, Sharron; Kawaguchi, Naomi; Geczy, Carolyn L

    2017-01-31

    S100A8 and S100A9 are myeloid cell-derived proteins that are elevated in several types of inflammatory lung disorders. Pro- and anti-inflammatory properties are reported and these proteins are proposed to activate TLR4. S100A8 and S100A9 can function separately, likely through distinct receptors but a systematic comparison of their effects in vivo are limited. Here we assess inflammation in murine lung following S100A9 and S100A8/A9 inhalation. Unlike S100A8, S100A9 promoted mild neutrophil and lymphocyte influx, possibly mediated in part, by increased mast cell degranulation and selective upregulation of some chemokine genes, particularly CXCL-10. S100 proteins did not significantly induce proinflammatory mediators including TNF-α, interleukin-1β (IL-1β), IL-6 or serum amyloid A3 (SAA3). In contrast to S100A8, neither preparation induced S100A8 or IL-10 mRNA/protein in airway epithelial cells, or in tracheal epithelial cells in vitro. Like S100A8, S100A9 and S100A8/A9 reduced neutrophil influx in acute lung injury provoked by lipopolysaccharide (LPS) challenge but were somewhat less inhibitory, possibly because of differential effects on expression of some chemokines, IL-1β, SAA3 and IL-10. Novel common pathways including increased induction of an NAD(+)-dependent protein deacetylase sirtuin-1 that may reduce NF-κB signalling, and increased STAT3 activation may reduce LPS activation. Results suggest a role for these proteins in normal homeostasis and protective mechanisms in the lung.Immunology and Cell Biology advance online publication, 31 January 2017; doi:10.1038/icb.2017.2.

  13. Carbon Dioxide, Hydrographic, and Chemical Data Obtained During the Nine R/V Korr Cruises Comprising the Indian Ocean CO2Survey (WOCE Sections I8SI9S, I9N, I8NI5E, I3, I5WI4, I7N, I1, I10, and I2; December 1, 1994-January 19, 1996)

    SciTech Connect

    Kozyr, A.V.

    2003-09-15

    This document describes the procedures and methods used to measure total carbon dioxide (TCO{sub 2}) and total alkalinity (TALK) at hydrographic stations taken during the R/V Knorr Indian Ocean cruises (Sections I8SI9S, I9N, I8NI5E, I3, I5WI4, I7N, I1, I10, and I2) in 1994-1996. The measurements were conducted as part of the World Ocean Circulation Experiment (WOCE). The expedition began in Fremantle, Australia, on December 1, 1994, and ended in Mombasa, Kenya, on January 22, 1996. During the nine cruises, 12 WOCE sections were occupied. Total carbon dioxide was extracted from water samples and measured using single-operator multiparameter metabolic analyzers (SOMMAs) coupled to coulometers. The overall precision and accuracy of the analyses was {+-} 1.20 {micro}mol/kg. The second carbonate system parameter, TALK, was determined by potentiometric titration. The precision of the measurements determined from 962 analyses of certified reference material was {+-} 4.2 {micro}mol/kg (REFERENCE). This work was supported by grants from the National Science Foundation, the U. S. Department of Energy, and the National Oceanographic and Atmospheric Administration. The R/V Knorr Indian Ocean data set is available as a numeric data package (NDP) from the Carbon Dioxide Information Analysis Center (CDIAC). The NDP consists of 18 oceanographic data files, two FORTRAN 77 data retrieval routine files, a readme file, and this printed documentation, which describes the contents and format of all files as well as the procedures and methods used to obtain the data. Instructions for accessing the data are provided.

  14. RDamage 6, 7, 8 & 9 Cassettes

    SciTech Connect

    Griego, Jeffrey R; Kaul, Ann

    2012-06-08

    The RDamage series of ten experiments is part of a long-term collaboration with RFNC/VNIIEF in pulsed power technology. These experiments use a cylindrical configuration to study spallation damage, which allows for a natural recollection of the damaged material under proper driving conditions and post-shot collection of the damaged target material for subsequent metallographic analysis. Dynamic insitu experimental velocimetry diagnostics are also employed. LANL is responsible for the design of the experimental load and velocimetry system. VNIIEF is responsible for the design and construction of the driving explosive magnetic generator. In the RDamage-0, -1 and -2 experiments, data was collected about failure initiation of a well-characterized material (aluminum) in a cylindrical geometry. The RDamage-3, -4 and -5 experiments produced data on the behavior of material recollected after damage from pressures in the damage initiation regime. Data on the behavior of material recollected after complete failure was collected in the RDamage-6, -7, -8 and -9 experiments. This presentation shows the evolution of the load assembly through the experimental series.

  15. 10 CFR 75.8 - IAEA inspections.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false IAEA inspections. 75.8 Section 75.8 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) SAFEGUARDS ON NUCLEAR MATERIAL-IMPLEMENTATION OF US/IAEA AGREEMENT General... notice from the U.S. Department of State. The applicant, licensee, or certificate holder should...

  16. 10 CFR 75.8 - IAEA inspections.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false IAEA inspections. 75.8 Section 75.8 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) SAFEGUARDS ON NUCLEAR MATERIAL-IMPLEMENTATION OF US/IAEA AGREEMENT General... notice from the U.S. Department of State. The applicant, licensee, or certificate holder should...

  17. 10 CFR 75.8 - IAEA inspections.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false IAEA inspections. 75.8 Section 75.8 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) SAFEGUARDS ON NUCLEAR MATERIAL-IMPLEMENTATION OF US/IAEA AGREEMENT General... notice from the U.S. Department of State. The applicant, licensee, or certificate holder should...

  18. 10 CFR 75.8 - IAEA inspections.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false IAEA inspections. 75.8 Section 75.8 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) SAFEGUARDS ON NUCLEAR MATERIAL-IMPLEMENTATION OF US/IAEA AGREEMENT General... notice from the U.S. Department of State. The applicant, licensee, or certificate holder should...

  19. 10 CFR 75.8 - IAEA inspections.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false IAEA inspections. 75.8 Section 75.8 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) SAFEGUARDS ON NUCLEAR MATERIAL-IMPLEMENTATION OF US/IAEA AGREEMENT General... notice from the U.S. Department of State. The applicant, licensee, or certificate holder should...

  20. 10 CFR 207.8 - Judicial actions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Judicial actions. 207.8 Section 207.8 Energy DEPARTMENT OF ENERGY OIL COLLECTION OF INFORMATION Collection of Information Under the Energy Supply and Environmental... district court within the jurisdiction of which any inquiry is carried on may, upon petition by...

  1. Oxidative damage to nucleic acids and benzo(a)pyrene-7,8-diol-9,10-epoxide-DNA adducts and chromosomal aberration in children with psoriasis repeatedly exposed to crude coal tar ointment and UV radiation.

    PubMed

    Borska, Lenka; Andrys, Ctirad; Krejsek, Jan; Palicka, Vladimir; Chmelarova, Marcela; Hamakova, Kvetoslava; Kremlacek, Jan; Fiala, Zdenek

    2014-01-01

    The paper presents a prospective cohort study. Observed group was formed of children with plaque psoriasis (n=19) treated by Goeckerman therapy (GT). The study describes adverse (side) effects associated with application of GT (combined exposure of 3% crude coal tar ointment and UV radiation). After GT we found significantly increased markers of oxidative stress (8-hydroxy-2'-deoxyguanosine, 8-hydroxyguanosine, and 8-hydroxyguanine), significantly increased levels of benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE) DNA adducts (BPDE-DNA), and significantly increased levels of total number of chromosomal aberrations in peripheral lymphocytes. We found significant relationship between (1) time of UV exposure and total number of aberrated cells and (2) daily topical application of 3% crude coal tar ointment (% of body surface) and level of BPDE-DNA adducts. The findings indicated increased hazard of oxidative stress and genotoxic effects related to the treatment. However, it must be noted that the oxidized guanine species and BPDE-DNA adducts also reflect individual variations in metabolic enzyme activity (different extent of bioactivation of benzo[a]pyrene to BPDE) and overall efficiency of DNA/RNA repair system. The study confirmed good effectiveness of the GT (significantly decreased PASI score).

  2. 43 CFR 10.9 - Inventories.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... objects, and, to the fullest extent possible based on information possessed by the museum or Federal... REPATRIATION REGULATIONS Human Remains, Funerary Objects, Sacred Objects, or Objects of Cultural Patrimony in Museums and Federal Collections § 10.9 Inventories. (a) General. This section carries out section 5 of...

  3. 43 CFR 10.9 - Inventories.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... objects, and, to the fullest extent possible based on information possessed by the museum or Federal... REPATRIATION REGULATIONS Human Remains, Funerary Objects, Sacred Objects, or Objects of Cultural Patrimony in Museums and Federal Collections § 10.9 Inventories. (a) General. This section carries out section 5 of...

  4. 32 CFR 9.10 - Other.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... requirement of the United States Constitution. Section and subsection captions in this document are for... MILITARY COMMISSIONS OF CERTAIN NON-UNITED STATES CITIZENS IN THE WAR AGAINST TERRORISM § 9.10 Other. This..., enforceable by any party, against the United States, its departments, agencies, or other entities,...

  5. 32 CFR 9.10 - Other.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... requirement of the United States Constitution. Section and subsection captions in this document are for... MILITARY COMMISSIONS OF CERTAIN NON-UNITED STATES CITIZENS IN THE WAR AGAINST TERRORISM § 9.10 Other. This..., enforceable by any party, against the United States, its departments, agencies, or other entities,...

  6. Magnetic field reversal of electric polarization and magnetoelectric phase diagram of the hexaferrite Ba1.3Sr0.7Co0.9Zn1.1Fe10.8Al1.2O22

    NASA Astrophysics Data System (ADS)

    Shen, Shipeng; Yan, Liqin; Chai, Yisheng; Cong, Junzhuang; Sun, Young

    2014-01-01

    Low magnetic field reversal of electric polarization has been demonstrated in the multiferroic Y-type hexaferrite Ba1.3Sr0.7Co0.9Zn1.1Fe10.8Al1.2O22 single crystal. The maximum magnetoelectric coefficient at 200 K reaches 1065 ps/m near zero magnetic field. By a systematic investigation of magnetic field dependence of magnetic and dielectric responses at various temperatures, we obtained the magnetoelectric phase diagram describing the detailed evolution of the spin-induced ferroelectric phases with temperature and magnetic field. Below 225 K, the transverse spin cone can be stabilized at zero magnetic field, which is responsible for the reversal behavior of electric polarization. Our study reveals how to eventually achieve magnetic field reversal of electric polarization in hexaferrites at room temperature.

  7. Nano-network with dual temperature and pH responsiveness based on copolymers of 2-hydroxyethyl methacrylate with 3,9-divinyl-2,4,8,10-tetraoxaspiro[5.5]-undecane

    NASA Astrophysics Data System (ADS)

    Chiriac, Aurica P.; Nita, Loredana E.; Nistor, Manuela T.

    2011-12-01

    This study refers to the synthesis of a nano-network with dual temperature and pH responsiveness based on the 2-hydroxyethyl methacrylate (HEMA) copolymers with a comonomer with spiroacetal moiety and crosslinking capacity, namely 3,9-divinyl-2,4,8,10-tetraoxaspiro[5.5]-undecane (U). The copolymers were synthesized by radical emulsion polymerization, using 4,4'-azobis(cyanopentanoic acid) as initiator, in the presence of sodium lauryl sulfate as tensioactive agent and poly(vinyl alcohol) as protective colloid. Three copolymer variants were taken into study resulted from the different ratio between the comonomers (HEMA/U), which was about 98/2, 95/5, and 90/10, respectively. The copolymers were characterized by FTIR and thermal analysis. The copolymers sensitivity was evidenced by studying the evolution of the hydrodynamic radius and zeta potential of the polymeric particles as a function of pH. Thus, the particles size increases with the comonomer amount, from 193 nm in case of the homopolymer up to 253 nm for the copolymer with maximum content of the comonomer (10%). The increase of the particle hydrodynamic radius with the growth of temperature was also put into evidence.

  8. 21 CFR 900.8-900.9 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false 900.8-900.9 Section 900.8-900.9 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MAMMOGRAPHY QUALITY STANDARDS ACT MAMMOGRAPHY Accreditation §§ 900.8-900.9...

  9. 8. Granite quay wall at foot of Pier 10 (west ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Granite quay wall at foot of Pier 10 (west end), view to north, at low tide. - Charlestown Navy Yard, Pier 10, Between Piers 9 & 11 along Mystic River on Charlestown Waterfront at eastern edge of Charlestown Navy Yard, Boston, Suffolk County, MA

  10. In vitro replication by prokaryotic and eukaryotic polymerases on DNA templates containing site-specific and stereospecific benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide adducts.

    PubMed Central

    Chary, P; Lloyd, R S

    1995-01-01

    DNA adducts of the environmental carcinogen benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE) interact stereospecifically with prokaryotic and eukaryotic polymerases in vitro. Toward understanding the capacity to replicate past different diastereomers of BPDE at specific sites in DNA, six deoxyoligonucleotides, each 33 bases long, were constructed with stereochemically defined BPDE adducts on adenine N6 at position two of the human N-ras codon 61. Four polymerases that were studied under single encounters with the template-primer complex terminated synthesis one base 3' to the lesion with all the adducted templates. When multiple encounters between polymerase and substrate were permitted, each of the polymerases analyzed revealed a unique pattern for a given adducted template. The general replication pattern was encompassed under two categories, reflecting the significance of the R and S configurations of C10 of the pyrenyl ring attached to the single-stranded DNA template. Furthermore, within each of these categories, every polymerase demonstrated distinct quantitative differences in product accumulation at a given site, for the various adducted templates. Among the polymerases utilized in this study, exonuclease-deficient Klenow fragment of polymerase I (exo- KF) exhibited the most efficient translesion synthesis resulting in approximately 16% full-length products with the modified templates bearing adducts with C10-S configuration. In contrast, chain elongation with bacteriophage T4 DNA polymerase bearing an active 3'-->5' exonucleolytic activity was most strongly inhibited by all six BPDE-adducted templates. Misincorporation of A opposite the adduct occurred in all the templates when polymerized with Sequenase, whereas exo- KF preferentially incorporated C opposite the C10-R BPDE adducts and A opposite the C10-S BPDE adducts. Images PMID:7753632

  11. Photocopy of drawing (this photograph is an 8' x 10' ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing (this photograph is an 8' x 10' copy of an 8' x 10' negative; 1952 original architectural drawing located at Building No. 458, NAS Pensacola, Florida) Conversion of Building No. 18 for overhaul and repair department electronics shop, existing first and second floor plan, sheet 9 of 21 - U.S. Naval Air Station, Marine Barracks, 232 East Avenue, Pensacola, Escambia County, FL

  12. 9 CFR 417.8 - Agency verification.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ANALYSIS AND CRITICAL CONTROL POINT (HACCP) SYSTEMS § 417.8 Agency verification. FSIS will verify the... deviation occurs; (d) Reviewing the critical limits; (e) Reviewing other records pertaining to the...

  13. DFT studies on a high-energy density cage compound 1, 3, 5, 7, 9, 11-hexo(N(CH3)NO2)-2, 4, 6, 8, 10, 12-hexaazatetracyclo[5, 5, 0, 0, 0] dodecane

    NASA Astrophysics Data System (ADS)

    Li, Xiao-Hong; Yong, Yong-Liang; Zhang, Xian-Zhou

    2014-04-01

    The infrared and Raman spectra, heat of formation (HOF) and thermodynamic properties were investigated by B3LYP/6-31G** method for a new designed polynitro cage compound 1,3,5,7,9,11-hexo(N(CH3)NO2)-2,4,6,8,10,12-hexaazatetracyclo[5,5,0,0,0]dodecane. The detonation velocity (D) and pressure (P) were predicted by the Kamlet-Jacobs equations based on the theoretical density and condensed HOF. The bond dissociation energies and bond orders for the weakest bonds were analysed to investigate the thermal stability of the title compound. The computational result shows that the detonation velocity and pressure of the title compound are superior to those of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), but inferior to those of 1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane (HMX) and hexanitrohexaazaisowurtzitane (HNIW). And the analysis of thermal stability shows that the first step of pyrolysis is the rupture of the N7-NO2 bond. The crystal structure obtained by molecular mechanics belongs to the P21 space group, with the lattice parameters Z = 2, a = 11.8246 Å, b = 10.4632 Å, c = 15.9713 Å, ρ = 1.98 g cm-3.

  14. 9 CFR 98.8 - Inspection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... EMBRYOS AND ANIMAL SEMEN Ruminant and Swine Embryos from Regions Free of Rinderpest and Foot-and-Mouth Disease; and Embryos of Horses and Asses § 98.8 Inspection. Any embryo offered for entry into the United States in accordance with this subpart and documents accompanying the embryo shall be subject...

  15. 9 CFR 98.8 - Inspection.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... EMBRYOS AND ANIMAL SEMEN Ruminant and Swine Embryos from Regions Free of Rinderpest and Foot-and-Mouth Disease; and Embryos of Horses and Asses § 98.8 Inspection. Any embryo offered for entry into the United States in accordance with this subpart and documents accompanying the embryo shall be subject...

  16. 9 CFR 98.8 - Inspection.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... EMBRYOS AND ANIMAL SEMEN Ruminant and Swine Embryos from Regions Free of Rinderpest and Foot-and-Mouth Disease; and Embryos of Horses and Asses § 98.8 Inspection. Any embryo offered for entry into the United States in accordance with this subpart and documents accompanying the embryo shall be subject...

  17. 9 CFR 98.8 - Inspection.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... EMBRYOS AND ANIMAL SEMEN Ruminant and Swine Embryos from Regions Free of Rinderpest and Foot-and-Mouth Disease; and Embryos of Horses and Asses § 98.8 Inspection. Any embryo offered for entry into the United States in accordance with this subpart and documents accompanying the embryo shall be subject...

  18. 9 CFR 98.8 - Inspection.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... EMBRYOS AND ANIMAL SEMEN Ruminant and Swine Embryos from Regions Free of Rinderpest and Foot-and-Mouth Disease; and Embryos of Horses and Asses § 98.8 Inspection. Any embryo offered for entry into the United States in accordance with this subpart and documents accompanying the embryo shall be subject...

  19. 28 CFR 8.9 - Disposition of forfeited property.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Disposition of forfeited property. 8.9 Section 8.9 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN STATUTES § 8.9 Disposition of forfeited property. (a) If the laws of a state in which an article of...

  20. 38 CFR 8.9 - Application and medical evidence.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Application and medical evidence. 8.9 Section 8.9 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS NATIONAL SERVICE LIFE INSURANCE Reinstatement § 8.9 Application and medical evidence. The applicant...

  1. 38 CFR 8.9 - Application and medical evidence.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Application and medical evidence. 8.9 Section 8.9 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS NATIONAL SERVICE LIFE INSURANCE Reinstatement § 8.9 Application and medical evidence. The applicant...

  2. 30 CFR 402.8-402.9 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false 402.8-402.9 Section 402.8-402.9 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH PROGRAM AND THE WATER-RESOURCES TECHNOLOGY DEVELOPMENT PROGRAM Description of Water-Resources Programs §§ 402.8-402.9...

  3. 30 CFR 402.8-402.9 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 2 2012-07-01 2012-07-01 false 402.8-402.9 Section 402.8-402.9 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH PROGRAM AND THE WATER-RESOURCES TECHNOLOGY DEVELOPMENT PROGRAM Description of Water-Resources Programs §§ 402.8-402.9...

  4. 30 CFR 402.8-402.9 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 2 2014-07-01 2014-07-01 false 402.8-402.9 Section 402.8-402.9 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH PROGRAM AND THE WATER-RESOURCES TECHNOLOGY DEVELOPMENT PROGRAM Description of Water-Resources Programs §§ 402.8-402.9...

  5. 30 CFR 402.8-402.9 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false 402.8-402.9 Section 402.8-402.9 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH PROGRAM AND THE WATER-RESOURCES TECHNOLOGY DEVELOPMENT PROGRAM Description of Water-Resources Programs §§ 402.8-402.9...

  6. 30 CFR 402.8-402.9 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false 402.8-402.9 Section 402.8-402.9 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH PROGRAM AND THE WATER-RESOURCES TECHNOLOGY DEVELOPMENT PROGRAM Description of Water-Resources Programs §§ 402.8-402.9...

  7. 28 CFR 8.9 - Disposition of forfeited property.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Disposition of forfeited property. 8.9 Section 8.9 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN STATUTES § 8.9 Disposition of forfeited property. (a) If the laws of a state in which an article of...

  8. 28 CFR 8.9 - Disposition of forfeited property.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Disposition of forfeited property. 8.9 Section 8.9 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN STATUTES § 8.9 Disposition of forfeited property. (a) If the laws of a state in which an article of...

  9. 36 CFR 9.8 - Use of water.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Use of water. 9.8 Section 9.8... MANAGEMENT Mining and Mining Claims § 9.8 Use of water. (a) No operator may use for operations any water from... Regional Director. The Regional Director shall not approve a plan of operations requiring the use of...

  10. 36 CFR 9.8 - Use of water.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Use of water. 9.8 Section 9.8... MANAGEMENT Mining and Mining Claims § 9.8 Use of water. (a) No operator may use for operations any water from... Regional Director. The Regional Director shall not approve a plan of operations requiring the use of...

  11. A σ(1) receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols (AHDs).

    PubMed

    Banister, Samuel D; Manoli, Miral; Doddareddy, Munikumar Reddy; Hibbs, David E; Kassiou, Michael

    2012-10-01

    A library of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols (AHDs) was synthesized and subjected to competition binding assays at σ(1) and σ(2) receptors, as well as off-target screening of representative members at 44 other common central nervous system (CNS) receptors, transporters, and ion channels. Excluding 3 low affinity analogs, 31 ligands demonstrated nanomolar K(i) values for either σ receptor subtype. Several selective σ(1) and σ(2) ligands were discovered, with selectivities of up to 29.6 times for σ(1) and 52.4 times for σ(2), as well as several high affinity, subtype non-selective ligands. The diversity of structures and σ(1) affinities of the ligands allowed the generation of a σ(1) receptor pharmacophore that will enable the rational design of increasingly selective and potent σ(1) ligands for probing σ(1) receptor function.

  12. A Photometric Study of Four Recently Discovered Contact Binaries: 1SWASP J064501.21+342154.9, 1SWASP J155822.10-025604.8, 1SWASP J212808.86+151622.0, and UCAC4 436-062932

    NASA Astrophysics Data System (ADS)

    Djurašević, G.; Essam, A.; Latković, O.; Cséki, A.; El-Sadek, M. A.; Abo-Elala, M. S.; Hayman, Z. M.

    2016-09-01

    We present new, high-quality multicolor observations of four recently discovered contact binaries, 1SWASP J064501.21+342154.9, 1SWASP J155822.10-025604.8, 1SWASP J212808.86+151622.0, and UCAC4 436-062932, and analyze their light curves to determine orbital and physical parameters using the modeling program of G. Djurašević. In the absence of spectroscopic observations, the effective temperatures of the brighter components are estimated from the color indices, and the mass ratios are determined with the q-search method. The analysis shows that all four systems are W UMa type binaries in shallow contact configurations, consisting of late-type main-sequence primaries and evolved secondaries with active surface regions (dark or bright spots) resulting from magnetic activity or ongoing transfer of thermal energy between the components. We compare the derived orbital and stellar parameters for these four variables with a large sample of previously analyzed W UMa stars and find that our results fit it well.

  13. Spectral investigation of the effect of anion on the stability of non covalent assemblies of 2,3,5,6,8,9,11,12-octahydro-1,4,7,10,13-benzopentaoxacyclopentadecine (benzo-15-crown-5) with sodium halides

    NASA Astrophysics Data System (ADS)

    Ghildiyal, Namrata; Pant, Geeta Joshi nee; Rawat, M. S. M.; Singh, Khushboo

    2017-01-01

    A series of complexes of 2,3,5,6,8,9,11,12-octahydro-1,4,7,10,13-benzopentaoxacyclopentadecine (benzo-15-crown-5) with sodium halides was synthesized in acetonitrile. The effect of anion on the stability and spectral properties of complexes of benzo-15-crown-5 with sodium halides was investigated. The synthesis of complexes of sodium fluoride and sodium chloride are reported for the first time. Chloroform was used as solvent to study the assembly in solution state by 1H and 13C NMR techniques. Single crystal diffraction studies on the easily crystallizable bromide complex confirmed 1:1 stoichiometry of the complex. IR and Raman studies provided valuable evidence for a water molecule shared between the crown encapsulated cation and the counter ion to give a solvent shared ion pair (SSIP). The fluorescence spectra of the complexes were obtained in chloroform by excitation at 270 nm to study the effect of complexation on the fluorescent properties of benzo-15-crown-5.

  14. Benzo[a]pyrene-7,8-diol-9,10-epoxide inhibits gap junction intercellular communication via phosphorylation of tumor progression locus 2 in WB-F344 rat liver epithelial cells.

    PubMed

    Lee, Bo Kyung; Chung, Min-Yu; Lee, Ki Won

    2015-05-01

    Benzo[a]pyrene-7,8-diol-9,10-epoxide (B[a]PDE), a major metabolite of benzo[a]pyrene, has been reported to function as a human carcinogen. However, the molecular mechanism of how B[a]PDE regulates signaling pathways during tumor promotion remains unclear. In this study, we investigated the effects of B[a]PDE on the regulation of gap junction intercellular communication (GJIC), one of the major carcinogenic processes, and its main regulatory signaling pathways using WB-F344 rat liver epithelial (WB-F344 RLE) cells. Treatment of benzo[a]pyrene or B[a]PDE resulted in GJIC inhibition, and B[a]PDE was more active at lower concentrations than benzo[a]pyrene in the suppression of GJIC. This suggests that B[a]PDE is a stronger GJIC inhibitor. B[a]PDE at 1 µM reversibly inhibited GJIC in WB-F344 RLE cells, which was attributable to hyperphosphorylation of connexin43 (Cx43) via phosphorylation of mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK) and extracellular signal-regulated kinase (ERK). We found that B[a]PDE induced phosphorylation of tumor progression locus 2 (Tpl2), a direct upstream regulator of MEK. Tpl2 inhibitor recovered B[a]PDE-induced GJIC inhibition and attenuated B[a]PDE-induced MEK/ERK phosphorylation in WB-F344 RLE cells. Collectively, our results suggest that B[a]PDE suppresses GJIC by activating Tpl2 and subsequently the MEK/ERK pathway and Cx43 phosphorylation in WB-F344 RLE cells. These results outline the potential importance of Tpl2 as a novel therapeutic target for B[a]PDE-induced GJIC inhibition during cancer promotion.

  15. Genetic polymorphisms in biotransformation enzymes for benzo[a]pyrene and related levels of benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA adducts in Goeckerman therapy.

    PubMed

    Beranek, Martin; Fiala, Zdenek; Kremlacek, Jan; Andrys, Ctirad; Hamakova, Kvetoslava; Chmelarova, Marcela; Palicka, Vladimir; Borska, Lenka

    2016-07-25

    Goeckerman therapy (GT) for psoriasis combines the therapeutic effect of crude coal tar (CCT) and ultraviolet radiation (UVR). CCT contains polycyclic aromatic hydrocarbons, some of which can form DNA adducts that may induce mutations and contribute to carcinogenesis. The aim of our work was to evaluate the relationship between concentrations of benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA adducts (BPDE-DNA adducts) and rs4646903 (CYP1A1 gene), rs1048943 (CYP1A1), rs1056836 (CYP1B1), rs1051740 (EPHX1), rs2234922 (EPHX1) and rs8175347 (UGT1A1) polymorphic sites, and GSTM1 null polymorphism in 46 patients with chronic stable plaque psoriasis who underwent GT. The level of BPDE-DNA adducts was determined using the OxiSelect BPDE-DNA Adduct ELISA Kit. Polymerase chain reaction (PCR) and restriction fragment length polymorphism analysis (rs4646903, rs1048943, rs1051740, and rs2234922), fragment analysis (rs8175347), real-time PCR (rs1056836), and digital droplet PCR polymorphism (GSTM1) were used. CYP1B1*1/*1 wild-type subjects and CYP1B1*3/*1 heterozygotes for rs1056836 formed significantly higher amounts of BPDE-DNA adducts than CYP1B1*3/*3 homozygotes (p=0.031 and p=0.005, respectively). Regarding rs1051740, individuals with EPHX1*3/*1 heterozygosity revealed fewer adducts than EPHX1*1/*1 wild-type subjects (p=0.026). Our data suggest that CYP1B1/EPHX1 genotyping could help to predict the risk of DNA damage and to optimize doses of coal tar and UVR exposure in psoriatic patients in whom GT was applied.

  16. Crystal structure of (1S,3R,8R,9R)-2,2-di­chloro-3,7,7-tri­methyl-10-methylenetri­cyclo­[6.4.0.01,3]dodecan-9-ol

    PubMed Central

    Benzalim, Ahmed; Auhmani, Aziz; Bimoussa, Abdoullah; Ait Itto, My Youssef; Daran, Jean-Claude; Auhmani, Abdelwahed

    2016-01-01

    The title compound, C16H24Cl2O, was synthesized by treating (1S,3R,8S,9R,10S)-2,2-di­chloro-3,7,7,10-tetra­methyl-9,10-ep­oxy­tri­cyclo­[6.4.0.01,3]dodecane with a concentrated solution of hydro­bromic acid. It is built up from three fused rings: a cyclo­heptane ring, a cyclo­hexyl ring bearing alkene and hy­droxy substituents, and a cyclo­propane ring bearing two chlorine atoms. The asymmetric unit contains two mol­ecules linked by an O—H⋯O hydrogen bond. In the crystal, further O—H⋯O hydrogen bonds build up an R 4 4(8) cyclic tetra­mer. One of the mol­ecules presents disorder that affects the seven-membered ring. In both mol­ecules, the six-membered rings display a chair conformation, whereas the seven-membered rings display conformations inter­mediate between boat and twist-boat for the non-disordered mol­ecule and either a chair or boat and twist-boat for the disordered mol­ecule owing to the disorder. The absolute configuration for both mol­ecules is 1S,3R,8R,9R and was deduced from the chemical pathway and further confirmed by the X-ray structural analysis. PMID:27536404

  17. Geoscience salaries up by 10.8%

    NASA Astrophysics Data System (ADS)

    Bell, Peter M.

    According to a recent salary survey of over 4000 scientists in all fields by Research and Development (March 1984) geoscientists ranked fourth place for 1984. Mathematics, aeronautical engineering, and metallurgy had higher median salaries, but the discipline of geoscience had a higher median salary than that of physics, chemical engineering, mechanical engineering, electrical engineering, ceramics, chemistry, industrial engineering, biology, and other fields of research and development. The 1984 median salary for geoscientists was $40,950, up from the median value by 10.8%. In 1983, geoscience was ranked in ninth place.The geoscientist profile for 1984 was not unusual. The median age was 47.5 years, and the median years of experience was 18. Geoscientists are the best educated. Eighty-two percent of the geoscientists polled had advanced degrees beyond the bachelor's degree. Fifty-six percent of the geoscientists had the Ph.D. degree.

  18. meso-[{Ru(phen)2}2(mu-HAT)]4+: a high-affinity DNA hairpin probe {HAT = 1,4,5,8,9,12-hexaazatriphenylene; phen = 1,10-phenanthroline}.

    PubMed

    Smith, Jayden A; Morgan, Joy L; Turley, Adam G; Collins, J Grant; Keene, F Richard

    2006-07-14

    1H NMR spectroscopy and fluorescent intercalator displacement (FID) assays have been used to investigate the DNA-binding abilities of two series of dinuclear polypyridyl ruthenium(II) complexes of the form [{Ru(L)2}2(mu-BL)]4+ {L = 2,2'-bipyridine (bpy), 4,4'-dimethyl-2,2'-bipyridine (Me2bpy), 1,10-phenanthroline (phen), or 4,7-dimethyl-1,10-phenanthroline (Me2phen); BL = 2,2'-bipyrimidine (bpm) or 1,4,5,8,9,12-hexaazatriphenylene (HAT)}. Preliminary FID surveys of these metal complexes against a variety of different oligonucleotides revealed that those complexes based upon the HAT bridging ligand induced greater fluorescence decreases in dye-bound DNA than did their bpm-bridged counterparts, suggesting a higher binding affinity by the HAT-bridged species. Furthermore, the greatest fluorescence decreases were typically observed in an oligonucleotide featuring a six-base hairpin loop. The apparent binding affinity of the metal complexes was also found to be a function of the stereochemistry and identity of the terminal ligands of the complex. The meso (DeltaLambda) stereoisomer generally induced greater fluorescence decreases than did either enantiomer (DeltaDelta or LambdaLambda), phen-based terminal ligands performed better than bpy-based terminal ligands, and those terminal ligands with methyl substituents demonstrated stronger apparent binding than did their non-methylated analogues. NMR experiments on meso-[{Ru(phen)2}2(mu-HAT)]4+ and meso-[{Ru(Me2phen)2}2(mu-HAT)]4+ demonstrated that both complexes bound with high affinity to the six-base hairpin oligonucleotide at the stem-loop interface and provided evidence to support stronger binding by the methylated species. meso-[{Ru(phen)2}2(mu-HAT)]4+ was found to bind poorly to duplex DNA and smaller four-base hairpin loops in FID and NMR experiments, whereas FID data suggest that the methylated analogue binds relatively strongly to most oligonucleotide sequences (the four- and six-base hairpins in particular). These

  19. Studies of the degradation mechanism of organic light-emitting diodes based on tris(8-quinolinolate)aluminum Alq and 2-tert-butyl-9,10-di(2-naphthyl)anthracene TBADN

    NASA Astrophysics Data System (ADS)

    Jarikov, Viktor V.; Kondakov, Denis Y.

    2009-02-01

    Previously, radical cation of tris(8-quinolinolate)aluminum (Alq•+) has been associated with the instability of Alq films subjected to holes-only electrical current. Yet, the questions remain (i) whether Alq•+ is the primary source of the intrinsic degradation of bipolar organic light-emitting diodes (OLEDs) based on Alq, (ii) whether Alq•+ reactions result in deep charge traps in holes-only devices as found in bipolar counterparts, and (iii) whether radical cations can be a common source of degradation of OLEDs irrespective of materials. With regards to generality of hole-current-related degradation, it is interesting to examine the behavior of 9,10-diarylanthracenes (DAAs)—the practically important class of blue-fluorescing light-emitting-layer hosts. These questions prompted our comparative study of the effects of unipolar currents in Alq and 2-t-butyl-9,10-di(2-naphthyl)anthracene (TBADN), which was chosen as a representative material of the DAA class. First, we identified device structures allowing for rigorous and stable unipolar conduction. Interestingly, even in pristine holes-only devices, our voltammetric measurements indicated that Alq contains a substantial density of deep hole traps (far deeper than what can be explained by energetic disorder), which can be charged by passing holes-only current and seemingly discharged by exposure to white light. As for aged holes-only Alq devices, they exhibited symptoms qualitatively matching those of aged bipolar Alq devices, viz., photoluminescence (PL) loss, transition voltage (V0) rise, and drive voltage (Vd) rise. Notably, PL and V0 are linearly correlated in both holes-only and bipolar devices, which reinforces the supposed link between Alq•+ and the degradation in both types of devices. Yet, there are indications the Alq•+ instability may not be the only degradation pathway in bipolar devices. Even though our observations for holes-only Alq devices agree qualitatively with previously reported ones

  20. 45 CFR 5.69 - Exemptions 8 and 9: Records on financial institutions; records on wells.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Exemptions 8 and 9: Records on financial institutions; records on wells. 5.69 Section 5.69 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION FREEDOM OF INFORMATION REGULATIONS Reasons for Withholding Some Records § 5.69 Exemptions 8 and 9: Records on...

  1. 3. KONGENSGADE (FRONT) ELEVATIONS OF KONGENSGADE 8 AND 9 (LEFT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. KONGENSGADE (FRONT) ELEVATIONS OF KONGENSGADE 8 AND 9 (LEFT TO RIGHT) (see photograph VI-50-1 for plans of Kongensgade 8 & 9) - King Street Area Study, Kongensgade 5-18, 36, 37B, 51-58 (Houses), 5-18, 36-37B, 51-58 King Street, Frederiksted, St. Croix, VI

  2. 36 CFR 9.8 - Use of water.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Use of water. 9.8 Section 9.8 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR MINERALS... reserved water right of the United States and can demonstrate that the exercise of that State water...

  3. 36 CFR 9.8 - Use of water.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Use of water. 9.8 Section 9.8 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR MINERALS... reserved water right of the United States and can demonstrate that the exercise of that State water...

  4. 36 CFR 9.8 - Use of water.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Use of water. 9.8 Section 9.8 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR MINERALS... reserved water right of the United States and can demonstrate that the exercise of that State water...

  5. 8 CFR 215.9 - Temporary Worker Visa Exit Program.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Temporary Worker Visa Exit Program. 215.9 Section 215.9 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS CONTROLS OF ALIENS DEPARTING FROM THE UNITED STATES § 215.9 Temporary Worker Visa Exit Program. An alien admitted...

  6. 8 CFR 215.9 - Temporary Worker Visa Exit Program.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Temporary Worker Visa Exit Program. 215.9 Section 215.9 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS CONTROLS OF ALIENS DEPARTING FROM THE UNITED STATES § 215.9 Temporary Worker Visa Exit Program. An alien admitted...

  7. 8 CFR 215.9 - Temporary Worker Visa Exit Program.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Temporary Worker Visa Exit Program. 215.9 Section 215.9 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS CONTROLS OF ALIENS DEPARTING FROM THE UNITED STATES § 215.9 Temporary Worker Visa Exit Program. An alien admitted...

  8. 8 CFR 215.9 - Temporary Worker Visa Exit Program.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Temporary Worker Visa Exit Program. 215.9 Section 215.9 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS CONTROLS OF ALIENS DEPARTING FROM THE UNITED STATES § 215.9 Temporary Worker Visa Exit Program. An alien admitted...

  9. 8 CFR 215.9 - Temporary Worker Visa Exit Program.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Temporary Worker Visa Exit Program. 215.9 Section 215.9 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS CONTROLS OF ALIENS DEPARTING FROM THE UNITED STATES § 215.9 Temporary Worker Visa Exit Program. An alien admitted...

  10. Durability Evaluation of the Effects of Hydro-processed Renewable Jet (HRJ) Blended at 50% with Petroleum JP-8 on a Navistar Maxxforce D10 9.3L Engine

    DTIC Science & Technology

    2012-05-01

    nif old C oo lan t En gin e I n Co ola nt En gin e Ou t...100 hour JP-8 Performance Run, Standard and DOC Data Summary UNCLASSIFIED A3 - 3 JP -8 10 0 H RS Ai r L FE Int ak e Ma nif old C AC De...CA C I nle t C AC ou tle t Int ak e Ma nif old C oo lan t En gin e I n Co ola nt En gin e Ou t Oi l S um p Te mp Fu el Be ak er Fu el

  11. Crystal structure of (1S,2R,6R,7R,8S,12S)-4,10,17-triphenyl-15-thia-4,10-diaza-penta-cyclo[5.5.5.0(1,16).0(2,6).0(8,12)]hepta-deca-13,16-diene-3,5,9,11-tetrone p-xylene hemisolvate.

    PubMed

    Noland, Wayland E; Kroll, Neil J; Huisenga, Matthew P; Yue, Ruixian A; Lang, Simon B; Klein, Nathan D; Tritch, Kenneth J

    2014-12-01

    The title tetrone compound, C32H22N2O4S· 0.5C8H10, is the major product (50% yield) of an attempted Diels-Alder reaction of 2-(α-styr-yl)thio-phene with N-phenyl-male-imide (2 equivalents) in toluene. Recrystallization of the resulting powder from p-xylene gave the title hemisolvate; the p-xylene mol-ecule is located about an inversion center. In the crystal, the primary tetrone contacts are between a carbonyl O atom and the four flagpole H atoms of the bi-cyclo-[2.2.2]octene core, forming chains along [001].

  12. 46 CFR 113.10-9 - Power supply.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Power supply. 113.10-9 Section 113.10-9 Shipping COAST... SYSTEMS AND EQUIPMENT Fire and Smoke Detecting and Alarm Systems § 113.10-9 Power supply. (a) General. There must be at least two sources of power for the electrical equipment of each fire detecting...

  13. 46 CFR 188.10-9 - Chemical storeroom.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Chemical storeroom. 188.10-9 Section 188.10-9 Shipping... PROVISIONS Definition of Terms Used in This Subchapter § 188.10-9 Chemical storeroom. This term refers to any compartment specifically constructed or modified for the stowage of chemical stores and so designated...

  14. 46 CFR 188.10-9 - Chemical storeroom.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Chemical storeroom. 188.10-9 Section 188.10-9 Shipping... PROVISIONS Definition of Terms Used in This Subchapter § 188.10-9 Chemical storeroom. This term refers to any compartment specifically constructed or modified for the stowage of chemical stores and so designated...

  15. 46 CFR 188.10-9 - Chemical storeroom.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Chemical storeroom. 188.10-9 Section 188.10-9 Shipping... PROVISIONS Definition of Terms Used in This Subchapter § 188.10-9 Chemical storeroom. This term refers to any compartment specifically constructed or modified for the stowage of chemical stores and so designated...

  16. 46 CFR 188.10-9 - Chemical storeroom.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Chemical storeroom. 188.10-9 Section 188.10-9 Shipping... PROVISIONS Definition of Terms Used in This Subchapter § 188.10-9 Chemical storeroom. This term refers to any compartment specifically constructed or modified for the stowage of chemical stores and so designated...

  17. 46 CFR 188.10-9 - Chemical storeroom.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Chemical storeroom. 188.10-9 Section 188.10-9 Shipping... PROVISIONS Definition of Terms Used in This Subchapter § 188.10-9 Chemical storeroom. This term refers to any compartment specifically constructed or modified for the stowage of chemical stores and so designated...

  18. 46 CFR 90.10-9 - Coast Guard District Commander.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Coast Guard District Commander. 90.10-9 Section 90.10-9 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS GENERAL PROVISIONS Definition of Terms Used in This Subchapter § 90.10-9 Coast Guard District Commander. This...

  19. 46 CFR 90.10-9 - Coast Guard District Commander.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Coast Guard District Commander. 90.10-9 Section 90.10-9 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS GENERAL PROVISIONS Definition of Terms Used in This Subchapter § 90.10-9 Coast Guard District Commander. This...

  20. 46 CFR 90.10-9 - Coast Guard District Commander.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Coast Guard District Commander. 90.10-9 Section 90.10-9 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS GENERAL PROVISIONS Definition of Terms Used in This Subchapter § 90.10-9 Coast Guard District Commander. This...

  1. 46 CFR 90.10-9 - Coast Guard District Commander.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Coast Guard District Commander. 90.10-9 Section 90.10-9 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS GENERAL PROVISIONS Definition of Terms Used in This Subchapter § 90.10-9 Coast Guard District Commander. This...

  2. 46 CFR 90.10-9 - Coast Guard District Commander.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Coast Guard District Commander. 90.10-9 Section 90.10-9 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS GENERAL PROVISIONS Definition of Terms Used in This Subchapter § 90.10-9 Coast Guard District Commander. This...

  3. 9 CFR 146.8 - Terminology and classification; slaughter plants.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Terminology and classification; slaughter plants. 146.8 Section 146.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... General Provisions § 146.8 Terminology and classification; slaughter plants. Participating...

  4. 9 CFR 112.8 - For export only.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false For export only. 112.8 Section 112.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS PACKAGING AND LABELING § 112.8 For...

  5. 9 CFR 112.8 - For export only.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false For export only. 112.8 Section 112.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS PACKAGING AND LABELING § 112.8 For...

  6. 9 CFR 146.8 - Terminology and classification; slaughter plants.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Terminology and classification; slaughter plants. 146.8 Section 146.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... General Provisions § 146.8 Terminology and classification; slaughter plants. Participating...

  7. 9 CFR 146.8 - Terminology and classification; slaughter plants.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Terminology and classification; slaughter plants. 146.8 Section 146.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... General Provisions § 146.8 Terminology and classification; slaughter plants. Participating...

  8. 9 CFR 146.8 - Terminology and classification; slaughter plants.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Terminology and classification; slaughter plants. 146.8 Section 146.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... General Provisions § 146.8 Terminology and classification; slaughter plants. Participating...

  9. 9 CFR 146.8 - Terminology and classification; slaughter plants.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Terminology and classification; slaughter plants. 146.8 Section 146.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... General Provisions § 146.8 Terminology and classification; slaughter plants. Participating...

  10. 9 CFR 166.8 - Vehicles used to transport garbage.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Vehicles used to transport garbage. 166.8 Section 166.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE SWINE HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.8...

  11. 9 CFR 166.8 - Vehicles used to transport garbage.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Vehicles used to transport garbage. 166.8 Section 166.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE SWINE HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.8...

  12. 9 CFR 166.8 - Vehicles used to transport garbage.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Vehicles used to transport garbage. 166.8 Section 166.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE SWINE HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.8...

  13. 9 CFR 166.8 - Vehicles used to transport garbage.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Vehicles used to transport garbage. 166.8 Section 166.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE SWINE HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.8...

  14. 9 CFR 3.8 - Exercise for dogs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Exercise for dogs. 3.8 Section 3.8... WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Dogs and Cats 1 Animal Health and Husbandry Standards § 3.8 Exercise for dogs. Dealers, exhibitors, and...

  15. 9 CFR 3.8 - Exercise for dogs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Exercise for dogs. 3.8 Section 3.8... WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Dogs and Cats 1 Animal Health and Husbandry Standards § 3.8 Exercise for dogs. Dealers, exhibitors, and...

  16. 9 CFR 3.8 - Exercise for dogs.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Exercise for dogs. 3.8 Section 3.8... WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Dogs and Cats 1 Animal Health and Husbandry Standards § 3.8 Exercise for dogs. Dealers, exhibitors, and...

  17. 9 CFR 3.8 - Exercise for dogs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Exercise for dogs. 3.8 Section 3.8... WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Dogs and Cats 1 Animal Health and Husbandry Standards § 3.8 Exercise for dogs. Dealers, exhibitors, and...

  18. 9 CFR 3.8 - Exercise for dogs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Exercise for dogs. 3.8 Section 3.8... WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Dogs and Cats 1 Animal Health and Husbandry Standards § 3.8 Exercise for dogs. Dealers, exhibitors, and...

  19. 9 CFR 112.8 - For export only.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false For export only. 112.8 Section 112.8..., SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS PACKAGING AND LABELING § 112.8 For export... States shall apply to such biological product if exported from the United States except as...

  20. 9 CFR 112.8 - For export only.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false For export only. 112.8 Section 112.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS PACKAGING AND LABELING § 112.8 For...

  1. 10 CFR 9.35 - Duplication fees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... § 9.21 at the NRC Public Document Room (PDR), One White Flint North, 11555 Rockville Pike, Room O-1F23... at One White Flint North, 11555 Rockville Pike (first floor), Rockville, Maryland. (1) Sizes up to...

  2. 10 CFR 9.35 - Duplication fees.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... § 9.21 at the NRC Public Document Room (PDR), One White Flint North, 11555 Rockville Pike, Room O-1F23... at One White Flint North, 11555 Rockville Pike (first floor), Rockville, Maryland. (1) Sizes up to...

  3. 10 CFR 9.35 - Duplication fees.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... § 9.21 at the NRC Public Document Room (PDR), One White Flint North, 11555 Rockville Pike, Room O-1F23... at One White Flint North, 11555 Rockville Pike (first floor), Rockville, Maryland. (1) Sizes up to...

  4. 10 CFR 9.35 - Duplication fees.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... § 9.21 at the NRC Public Document Room (PDR), One White Flint North, 11555 Rockville Pike, Room O-1F23... at One White Flint North, 11555 Rockville Pike (first floor), Rockville, Maryland. (1) Sizes up to...

  5. Crystal structure of 2,9-diphenyl-17λ(6)-thia-tetra-cyclo-[8.7.0.0(3,8).0(11,16)]hepta-deca-1(10),2,4,6,8,11(16),12,14-octa-ene-17,17-dione.

    PubMed

    Gopinath, S; Narayanan, P; Sethusankar, K; Nandakumar, Meganathan; Mohanakrishnan, Arasambattu K

    2014-09-01

    The title compound, C28H18O2S, is composed of a naphthalene ring system fused with a benzo-thio-phene ring and attached to two phenyl rings. The phenyl rings make dihedral angles of 70.92 (8) and 79.23 (8)° with the essentially planar naphthalene ring system (r.m.s. deviation = 0.031 Å). There is an intra-molecular C-H⋯π inter-action present. In the crystal, mol-ecules are linked by C-H⋯O hydrogen bonds which generate C(7) zigzag chains running parallel to [10-1]. The chains are linked via further C-H⋯π inter-actions, forming a three-dimensional structure.

  6. 10 CFR 9.101 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... COMMISSION PUBLIC RECORDS Government in the Sunshine Act Regulations § 9.101 Definitions. As used in this subpart: (a) Commission means the collegial body of five Commissioners or a quorum thereof as provided by...) Commissioner means an individual who is a member of the Commission. (c) Meeting means the deliberations of...

  7. 9 CFR 441.10 - Retained water.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... temperature and the pressure or amount of buffeting applied to birds by feather removal machinery, and the.../temperature requirements set forth in 9 CFR 381.66. Additional purposes that could be included are determining... chiller types, identified by the mechanism used to transport the birds through the chiller or to...

  8. 9 CFR 441.10 - Retained water.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... temperature and the pressure or amount of buffeting applied to birds by feather removal machinery, and the.../temperature requirements set forth in 9 CFR 381.66. Additional purposes that could be included are determining... chiller types, identified by the mechanism used to transport the birds through the chiller or to...

  9. 9 CFR 441.10 - Retained water.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... temperature and the pressure or amount of buffeting applied to birds by feather removal machinery, and the.../temperature requirements set forth in 9 CFR 381.66. Additional purposes that could be included are determining... chiller types, identified by the mechanism used to transport the birds through the chiller or to...

  10. 9 CFR 441.10 - Retained water.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... temperature and the pressure or amount of buffeting applied to birds by feather removal machinery, and the.../temperature requirements set forth in 9 CFR 381.66. Additional purposes that could be included are determining... chiller types, identified by the mechanism used to transport the birds through the chiller or to...

  11. 9 CFR 441.10 - Retained water.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... temperature and the pressure or amount of buffeting applied to birds by feather removal machinery, and the.../temperature requirements set forth in 9 CFR 381.66. Additional purposes that could be included are determining... chiller types, identified by the mechanism used to transport the birds through the chiller or to...

  12. 9. Historic American Buildings Survey Alex Bush, Photographer, January 8, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Historic American Buildings Survey Alex Bush, Photographer, January 8, 1937 LOOKING NORTH EAST IN COURT ROOM - Wilcox County Courthouse, Broad, Claiborne, Court & Water Streets, Camden, Wilcox County, AL

  13. 8. Historic American Buildings Survey Alex Bush, Photographer, November 9, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Historic American Buildings Survey Alex Bush, Photographer, November 9, 1936 NORTH WEST CORNER OF ROOM ON SECOND FLOOR SHOWING WINDOW AND MANTEL - Strawberry Hill Plantation, U.S. Route 43, Forkland, Greene County, AL

  14. The {sup 9}Be({sup 8}Li,{sup 9}Be){sup 8}Li elastic-transfer reaction

    SciTech Connect

    Camargo, O.; Guimaraes, V.; Lichtenthaeler, R.; Scarduelli, V.; Kolata, J. J.; Bertulani, C. A.; Amro, H.; Becchetti, F. D.; Jiang Hao; Aguilera, E. F.; Lizcano, D.; Martinez-Quiroz, E.; Garcia, H.

    2008-09-15

    Angular distributions for the {sup 9}Be({sup 8}Li,{sup 9}Be){sup 8}Li elastic-transfer reaction have been measured with a 27-MeV {sup 8}Li radioactive nuclear beam. Spectroscopic factors for the <{sup 9}Be|{sup 8}Li+p> bound system were obtained from the comparison between the experimental differential cross sections and finite-range distorted-wave Born approximation calculations made with the code FRESCO. The spectroscopic factors so obtained are compared with shell-model calculations and other experimental values. Using the present value for the spectroscopic factors, cross sections and reaction rates for the {sup 8}Li(p,{gamma}){sup 9}Be direct proton-capture reaction of astrophysical interest were calculated in the framework of the potential model.

  15. 9 CFR 354.10 - Inspection service.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Basis of Service § 354.10...

  16. Inhibition of dipeptidyl peptidase 8/9 impairs preadipocyte differentiation

    PubMed Central

    Han, Ruijun; Wang, Xinying; Bachovchin, William; Zukowska, Zofia; Osborn, John W.

    2015-01-01

    Adipocytes are the primary cells in adipose tissue, and adipocyte dysfunction causes lipodystrophy, obesity and diabetes. The dipeptidyl peptidase (DPP) 4 family includes four enzymes, DPP4, DPP8, DPP9 and fibroblast activation protein (FAP). DPP4 family inhibitors have been used for the treatment of type 2 diabetes patients, but their role in adipocyte formation are poorly understood. Here we demonstrate that the DPP8/9 selective inhibitor 1G244 blocks adipogenesis in preadipocyte 3T3-L1 and 3T3-F422A, while DPP4 and FAP inhibitors have no effect. In addition, knockdown of DPP8 or DPP9 significantly impairs adipocyte differentiation in preadipocytes. We further uncovered that blocking the expression or activities of DPP8 and DPP9 attenuates PPARγ2 induction during preadipocyte differentiation. Addition of PPARγ agonist thiazolidinediones (TZDs), or ectopic expression of PPARγ2, is able to rescue the adipogenic defect caused by DPP8/9 inhibition in preadipocytes. These results indicate the importance of DPP8 and DPP9 on adipogenesis. PMID:26242871

  17. 8 CFR 1235.9 - Northern Marianas identification card.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Northern Marianas identification card. 1235.9 Section 1235.9 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF... Identification Cards to aliens who acquired United States citizenship when the Covenant to Establish...

  18. 8 CFR 235.9 - Northern Marianas identification card.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Northern Marianas identification card. 235.9 Section 235.9 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS... aliens who acquired United States citizenship when the Covenant to Establish a Commonwealth of...

  19. 8 CFR 207.9 - Termination of refugee status.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Termination of refugee status. 207.9... REFUGEES § 207.9 Termination of refugee status. The refugee status of any alien (and of the spouse or child... district director in whose district the alien is found if the alien was not a refugee within the meaning...

  20. 8 CFR 1235.9 - Northern Marianas identification card.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Northern Marianas identification card. 1235.9 Section 1235.9 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF... November 3, 1986. These cards remain valid as evidence of United States citizenship. Although the...

  1. 8 CFR 235.9 - Northern Marianas identification card.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Northern Marianas identification card. 235.9 Section 235.9 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS... Northern Mariana Islands in Political Union with the United States entered into force on November 3,...

  2. 8 CFR 207.9 - Termination of refugee status.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Termination of refugee status. 207.9... REFUGEES § 207.9 Termination of refugee status. The refugee status of any alien (and of the spouse or child... district director in whose district the alien is found if the alien was not a refugee within the meaning...

  3. 8 CFR 207.9 - Termination of refugee status.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Termination of refugee status. 207.9... REFUGEES § 207.9 Termination of refugee status. The refugee status of any alien (and of the spouse or child... if the alien was not a refugee within the meaning of section 101(a)(42) of the Act at the time...

  4. 8 CFR 207.9 - Termination of refugee status.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Termination of refugee status. 207.9... REFUGEES § 207.9 Termination of refugee status. The refugee status of any alien (and of the spouse or child... if the alien was not a refugee within the meaning of section 101(a)(42) of the Act at the time...

  5. 8 CFR 207.9 - Termination of refugee status.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Termination of refugee status. 207.9... REFUGEES § 207.9 Termination of refugee status. The refugee status of any alien (and of the spouse or child... if the alien was not a refugee within the meaning of section 101(a)(42) of the Act at the time...

  6. 10 CFR 605.8 - Solicitation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... submission of applications; and (v) Any evaluation criteria in addition to those set forth in § 605.10. (2... as: (i) Program objectives, (ii) A project agenda or potential areas for project initiatives,...

  7. 9 CFR 108.8 - Construction of buildings.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... protection of the products and personnel. (e) The supply of hot and cold water at licensed establishments... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Construction of buildings. 108.8... LICENSED ESTABLISHMENTS § 108.8 Construction of buildings. (a) The floors, walls, ceilings,...

  8. 9 CFR 108.8 - Construction of buildings.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... protection of the products and personnel. (e) The supply of hot and cold water at licensed establishments... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Construction of buildings. 108.8... LICENSED ESTABLISHMENTS § 108.8 Construction of buildings. (a) The floors, walls, ceilings,...

  9. 9 CFR 108.8 - Construction of buildings.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... protection of the products and personnel. (e) The supply of hot and cold water at licensed establishments... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Construction of buildings. 108.8... LICENSED ESTABLISHMENTS § 108.8 Construction of buildings. (a) The floors, walls, ceilings,...

  10. 9 CFR 166.8 - Vehicles used to transport garbage.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Vehicles used to transport garbage. 166.8 Section 166.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT... used to transport garbage. Vehicles used by a licensee to transport untreated garbage, except...

  11. 9 CFR 390.8 - Agency response to requests.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Agency response to requests. 390.8 Section 390.8 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND INSPECTION SERVICE ADMINISTRATIVE PROVISIONS FREEDOM OF INFORMATION AND...

  12. 9 CFR 390.8 - Agency response to requests.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Agency response to requests. 390.8 Section 390.8 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND INSPECTION SERVICE ADMINISTRATIVE PROVISIONS FREEDOM OF INFORMATION AND...

  13. 9 CFR 390.8 - Agency response to requests.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Agency response to requests. 390.8 Section 390.8 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND INSPECTION SERVICE ADMINISTRATIVE PROVISIONS FREEDOM OF INFORMATION AND...

  14. 9 CFR 390.8 - Agency response to requests.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Agency response to requests. 390.8 Section 390.8 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND INSPECTION SERVICE ADMINISTRATIVE PROVISIONS FREEDOM OF INFORMATION AND...

  15. 9 CFR 390.8 - Agency response to requests.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Agency response to requests. 390.8 Section 390.8 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND INSPECTION SERVICE ADMINISTRATIVE PROVISIONS FREEDOM OF INFORMATION AND...

  16. 9 CFR 53.8 - Presentation of claims.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Presentation of claims. 53.8 Section 53.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE COOPERATIVE CONTROL AND ERADICATION OF LIVESTOCK OR POULTRY DISEASES FOOT-AND-MOUTH...

  17. 9 CFR 53.8 - Presentation of claims.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Presentation of claims. 53.8 Section 53.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE COOPERATIVE CONTROL AND ERADICATION OF LIVESTOCK OR POULTRY DISEASES FOOT-AND-MOUTH...

  18. 9 CFR 53.8 - Presentation of claims.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Presentation of claims. 53.8 Section 53.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE COOPERATIVE CONTROL AND ERADICATION OF LIVESTOCK OR POULTRY DISEASES FOOT-AND-MOUTH...

  19. 9 CFR 53.8 - Presentation of claims.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Presentation of claims. 53.8 Section 53.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE COOPERATIVE CONTROL AND ERADICATION OF LIVESTOCK OR POULTRY DISEASES FOOT-AND-MOUTH...

  20. 9 CFR 53.8 - Presentation of claims.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Presentation of claims. 53.8 Section 53.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE COOPERATIVE CONTROL AND ERADICATION OF LIVESTOCK OR POULTRY DISEASES FOOT-AND-MOUTH...

  1. 9 CFR 78.8 - Brucellosis exposed cattle.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Brucellosis exposed cattle. 78.8... AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS BRUCELLOSIS Restrictions on Interstate Movement of Cattle Because of Brucellosis § 78.8 Brucellosis exposed...

  2. 9 CFR 112.8 - For export only.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false For export only. 112.8 Section 112.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES... may authorize by permit the importation of a limited number for research and evaluation by...

  3. 8. Photographic copy of construction drawing, dated June 9, 1954, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Photographic copy of construction drawing, dated June 9, 1954, Norman Krecke, Architect, Detroit, in possession of Selfridge Base Museum, Mt. Clemens, Michigan. SECOND FLOOR AND ROOF PLANS, SHEET 3 OF 8 SF 5/308. - Selfridge Field, Building No. 567, East Joy Boulevard east of Northwest Gate, Mount Clemens, Macomb County, MI

  4. 9 CFR 114.8 - Outline of Production required.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Outline of Production required. 114.8 Section 114.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF... Animal and Plant Health Inspection Service for each licensed biological product or for each...

  5. 9 CFR 114.8 - Outline of Production required.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Outline of Production required. 114.8 Section 114.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF... Animal and Plant Health Inspection Service for each licensed biological product or for each...

  6. 9 CFR 114.8 - Outline of Production required.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Outline of Production required. 114.8 Section 114.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF... Animal and Plant Health Inspection Service for each licensed biological product or for each...

  7. 9 CFR 114.8 - Outline of Production required.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Outline of Production required. 114.8 Section 114.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF... Animal and Plant Health Inspection Service for each licensed biological product or for each...

  8. 9 CFR 314.8 - Dead animal carcasses.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Dead animal carcasses. 314.8 Section 314.8 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... Dead animal carcasses. (a) With the exception of dead livestock which have died en route and...

  9. 9 CFR 314.8 - Dead animal carcasses.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Dead animal carcasses. 314.8 Section 314.8 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... Dead animal carcasses. (a) With the exception of dead livestock which have died en route and...

  10. 9 CFR 314.8 - Dead animal carcasses.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Dead animal carcasses. 314.8 Section 314.8 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... Dead animal carcasses. (a) With the exception of dead livestock which have died en route and...

  11. 9 CFR 314.8 - Dead animal carcasses.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Dead animal carcasses. 314.8 Section 314.8 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... Dead animal carcasses. (a) With the exception of dead livestock which have died en route and...

  12. 9 CFR 314.8 - Dead animal carcasses.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Dead animal carcasses. 314.8 Section 314.8 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... Dead animal carcasses. (a) With the exception of dead livestock which have died en route and...

  13. 9 CFR 108.8 - Construction of buildings.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Construction of buildings. 108.8 Section 108.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS FACILITY REQUIREMENTS...

  14. 9 CFR 108.8 - Construction of buildings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Construction of buildings. 108.8 Section 108.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS FACILITY REQUIREMENTS...

  15. 9 CFR 145.8 - Terminology and classification; general.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Terminology and classification; general. 145.8 Section 145.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING...

  16. 9 CFR 145.8 - Terminology and classification; general.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Terminology and classification; general. 145.8 Section 145.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING...

  17. 9 CFR 145.8 - Terminology and classification; general.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Terminology and classification; general. 145.8 Section 145.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING...

  18. 9 CFR 145.8 - Terminology and classification; general.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Terminology and classification; general. 145.8 Section 145.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING...

  19. 9 CFR 145.8 - Terminology and classification; general.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Terminology and classification; general. 145.8 Section 145.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING...

  20. 10 CFR 784.8 - Procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ENERGY PATENT WAIVER REGULATION § 784.8 Procedures. (a) All requests for waivers shall be in writing... the case of requests for waiver of identified inventions. (b) A request for an advance waiver should... within such longer period as may be authorized by Patent Counsel for good cause shown in writing. If...

  1. 9 CFR 98.10 - Other importations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... EMBRYOS AND ANIMAL SEMEN Ruminant and Swine Embryos from Regions Free of Rinderpest and Foot-and-Mouth Disease; and Embryos of Horses and Asses § 98.10 Other importations. Notwithstanding other provisions in... States of embryos other than as provided for in this part under such conditions as the Administrator...

  2. 9 CFR 98.10 - Other importations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... EMBRYOS AND ANIMAL SEMEN Ruminant and Swine Embryos from Regions Free of Rinderpest and Foot-and-Mouth Disease; and Embryos of Horses and Asses § 98.10 Other importations. Notwithstanding other provisions in... States of embryos other than as provided for in this part under such conditions as the Administrator...

  3. 9 CFR 98.10 - Other importations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... EMBRYOS AND ANIMAL SEMEN Ruminant and Swine Embryos from Regions Free of Rinderpest and Foot-and-Mouth Disease; and Embryos of Horses and Asses § 98.10 Other importations. Notwithstanding other provisions in... States of embryos other than as provided for in this part under such conditions as the Administrator...

  4. 9 CFR 98.10 - Other importations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... EMBRYOS AND ANIMAL SEMEN Ruminant and Swine Embryos from Regions Free of Rinderpest and Foot-and-Mouth Disease; and Embryos of Horses and Asses § 98.10 Other importations. Notwithstanding other provisions in... States of embryos other than as provided for in this part under such conditions as the Administrator...

  5. 9 CFR 98.10 - Other importations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... EMBRYOS AND ANIMAL SEMEN Ruminant and Swine Embryos from Regions Free of Rinderpest and Foot-and-Mouth Disease; and Embryos of Horses and Asses § 98.10 Other importations. Notwithstanding other provisions in... States of embryos other than as provided for in this part under such conditions as the Administrator...

  6. 9 CFR 71.10 - Permitted disinfectants.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... § 71.10 Permitted disinfectants. (a) Disinfectants permitted for use on cars, boats, and other vehicles... least 4 fluid ounces to 1 gallon of water. (2) Liquefied phenol (U.S.P. strength 87 percent phenol) in the proportion of at least 6 fluid ounces to 1 gallon of water. (3) Chlorinated lime (U.S.P....

  7. 9 CFR 71.10 - Permitted disinfectants.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... § 71.10 Permitted disinfectants. (a) Disinfectants permitted for use on cars, boats, and other vehicles... least 4 fluid ounces to 1 gallon of water. (2) Liquefied phenol (U.S.P. strength 87 percent phenol) in the proportion of at least 6 fluid ounces to 1 gallon of water. (3) Chlorinated lime (U.S.P....

  8. 9 CFR 166.10 - Licensing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE SWINE HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.10 Licensing. (a) Application. Any... swine shall apply for a license on a form which will be furnished, upon request, by the...

  9. 9 CFR 166.10 - Licensing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE SWINE HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.10 Licensing. (a) Application. Any... swine shall apply for a license on a form which will be furnished, upon request, by the...

  10. 9 CFR 166.10 - Licensing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE SWINE HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.10 Licensing. (a) Application. Any... swine shall apply for a license on a form which will be furnished, upon request, by the...

  11. 9 CFR 166.10 - Licensing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE SWINE HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.10 Licensing. (a) Application. Any... swine shall apply for a license on a form which will be furnished, upon request, by the...

  12. 9 CFR 166.10 - Licensing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE SWINE HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.10 Licensing. (a) Application. Any... swine shall apply for a license on a form which will be furnished, upon request, by the...

  13. 9 CFR 351.10 - Facilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... CERTIFICATION CERTIFICATION OF TECHNICAL ANIMAL FATS FOR EXPORT Facilities and Operations § 351.10 Facilities. (a) Facilities for the preparation, identification, and storage of the technical animal fat to be... maintain the identity of certified technical animal fats and materials used in their preparation,...

  14. 9 CFR 351.10 - Facilities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... CERTIFICATION CERTIFICATION OF TECHNICAL ANIMAL FATS FOR EXPORT Facilities and Operations § 351.10 Facilities. (a) Facilities for the preparation, identification, and storage of the technical animal fat to be... maintain the identity of certified technical animal fats and materials used in their preparation,...

  15. 9 CFR 351.10 - Facilities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... CERTIFICATION CERTIFICATION OF TECHNICAL ANIMAL FATS FOR EXPORT Facilities and Operations § 351.10 Facilities. (a) Facilities for the preparation, identification, and storage of the technical animal fat to be... maintain the identity of certified technical animal fats and materials used in their preparation,...

  16. 9 CFR 351.10 - Facilities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... CERTIFICATION CERTIFICATION OF TECHNICAL ANIMAL FATS FOR EXPORT Facilities and Operations § 351.10 Facilities. (a) Facilities for the preparation, identification, and storage of the technical animal fat to be... maintain the identity of certified technical animal fats and materials used in their preparation,...

  17. 9 CFR 351.10 - Facilities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... CERTIFICATION CERTIFICATION OF TECHNICAL ANIMAL FATS FOR EXPORT Facilities and Operations § 351.10 Facilities. (a) Facilities for the preparation, identification, and storage of the technical animal fat to be... maintain the identity of certified technical animal fats and materials used in their preparation,...

  18. 9 CFR 3.10 - Watering.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Cats 1 Animal Health and Husbandry Standards § 3.10 Watering. If potable water is not continually available to the dogs and cats, it must be offered to the dogs and cats as often as necessary to ensure... with § 3.11(b) of this subpart, and before being used to water a different dog or cat or...

  19. 9 CFR 3.10 - Watering.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Cats 1 Animal Health and Husbandry Standards § 3.10 Watering. If potable water is not continually available to the dogs and cats, it must be offered to the dogs and cats as often as necessary to ensure... with § 3.11(b) of this subpart, and before being used to water a different dog or cat or...

  20. 9 CFR 3.10 - Watering.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Cats 1 Animal Health and Husbandry Standards § 3.10 Watering. If potable water is not continually available to the dogs and cats, it must be offered to the dogs and cats as often as necessary to ensure... with § 3.11(b) of this subpart, and before being used to water a different dog or cat or...

  1. 9 CFR 3.10 - Watering.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Cats 1 Animal Health and Husbandry Standards § 3.10 Watering. If potable water is not continually available to the dogs and cats, it must be offered to the dogs and cats as often as necessary to ensure... with § 3.11(b) of this subpart, and before being used to water a different dog or cat or...

  2. 9 CFR 3.10 - Watering.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Cats 1 Animal Health and Husbandry Standards § 3.10 Watering. If potable water is not continually available to the dogs and cats, it must be offered to the dogs and cats as often as necessary to ensure... with § 3.11(b) of this subpart, and before being used to water a different dog or cat or...

  3. 17 CFR 10.9 - Separation of functions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 1 2014-04-01 2014-04-01 false Separation of functions. 10.9 Section 10.9 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION RULES OF PRACTICE General Provisions § 10.9 Separation of functions. (a) An Administrative Law Judge will not be...

  4. 17 CFR 10.9 - Separation of functions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 1 2011-04-01 2011-04-01 false Separation of functions. 10.9 Section 10.9 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION RULES OF PRACTICE General Provisions § 10.9 Separation of functions. (a) An Administrative Law Judge will not be...

  5. 17 CFR 10.9 - Separation of functions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false Separation of functions. 10.9 Section 10.9 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION RULES OF PRACTICE General Provisions § 10.9 Separation of functions. (a) An Administrative Law Judge will not be...

  6. 17 CFR 10.9 - Separation of functions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 1 2013-04-01 2013-04-01 false Separation of functions. 10.9 Section 10.9 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION RULES OF PRACTICE General Provisions § 10.9 Separation of functions. (a) An Administrative Law Judge will not be...

  7. 17 CFR 10.9 - Separation of functions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Separation of functions. 10.9 Section 10.9 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION RULES OF PRACTICE General Provisions § 10.9 Separation of functions. (a) An Administrative Law Judge will not be...

  8. 8 CFR 1240.10 - Hearing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS PROCEEDINGS TO DETERMINE REMOVABILITY OF ALIENS IN THE UNITED STATES Removal Proceedings § 1240.10 Hearing. (a... government may proffer in opposition to the respondent's admission to the United States or to an...

  9. 8 CFR 1240.10 - Hearing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS PROCEEDINGS TO DETERMINE REMOVABILITY OF ALIENS IN THE UNITED STATES Removal Proceedings § 1240.10 Hearing. (a... government may proffer in opposition to the respondent's admission to the United States or to an...

  10. 8 CFR 1240.10 - Hearing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS PROCEEDINGS TO DETERMINE REMOVABILITY OF ALIENS IN THE UNITED STATES Removal Proceedings § 1240.10 Hearing. (a... government may proffer in opposition to the respondent's admission to the United States or to an...

  11. 8 CFR 1240.10 - Hearing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS PROCEEDINGS TO DETERMINE REMOVABILITY OF ALIENS IN THE UNITED STATES Removal Proceedings § 1240.10 Hearing. (a... government may proffer in opposition to the respondent's admission to the United States or to an...

  12. 8 CFR 1240.10 - Hearing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS PROCEEDINGS TO DETERMINE REMOVABILITY OF ALIENS IN THE UNITED STATES Removal Proceedings § 1240.10 Hearing. (a... government may proffer in opposition to the respondent's admission to the United States or to an...

  13. Theoretical study of stereoselectivity of the [1 + 2] cycloaddition reaction between (1S,3R,8S)-2,2-dichloro-3,7,7,10-tetramethyltricyclo[6,4,0,0(1.3)]dodec-9-ene and dibromocarbene using density functional theory (DFT) B3LYP/6-31G*(d).

    PubMed

    Zeroual, Abdellah; Benharref, Ahmed; El Hajbi, Abdeslam

    2015-03-01

    In this work we used density functional theory (DFT) B3LYP/6-31G*(d) to study the stoichiometric reaction between the product (1S,3R,8S)-2,2-dichloro-3,7,7,10-tetramethyltricyclo[6,4,0,0(1.3)]dodec-9-ene (referred to here as P1) and dibromocarbene. We have shown that P1 behaves as a nucleophile, while dibromocarbene behaves as an electrophile; that the chemical potential of dibromocarbene is superior to that of P1 in absolute terms; and that P1 reacts with an equivalent quantity of dibromocarbene to produce two products: (1S,3R,8R,9S,11R)-10,10-dibromo-2,2-dichloro-3,7,7,11-tetramethyltetracyclo[6,5,0,0(1.3),0(9.11)] tridecane (referred to here as P2) and (1S,3R,8R,9R,11S)-10,10-dibromo-2,2-dichloro-3,7,7,11-tetramethyltetracyclo[6,5,0,0(1.3),0(9.11)] tridecane (referred to here as P3). P2 and P3 are formed at the α and β sides, respectively, of the C2 = C3 double bond of P1. This reaction is exothermic, stereoselective and chemospecific, and is controlled by charge transfer. Regioselectivity of the reaction was interpreted using the Lee-Yang-Parr functional.

  14. 9,10-Dihydroxy-9,10-dihydro-3-methylcholanthrene-2-one: a principal metabolite of the potent carcinogen 3-methylcholanthrene-2-one by rat liver microsomes.

    PubMed

    Shou, M; Yang, S K

    1990-04-01

    A principal metabolite, formed in the metabolism of the potent carcinogen 3-methylcholanthrene-2-one (3MC-2-one) by liver microsomes from either untreated, or phenobarbital-treated or 3-methylcholanthrene (3MC)-treated rats, was isolated by reversed-phase HPLC. This metabolite has been identified as a 9,10-dihydrodiol with a (9R,10R):(9S,10S) enantiomer ratio of approximately 84:16 by all three rat liver microsomal preparations. The 9,10-dihydrodiol metabolite and its NaBH4 reduction products [a pair of diastereomeric 9,10-dihydroxy-9, 10-dihydro-2-OH-3MC (2-OH-3MC 9,10-dihydrodiols)] were characterized by UV-visible absorption, mass, and circular dichroic spectral, and chiral stationary phase HPLC analyses. Identification of 9,10-dihydroxy-9,10-dihydro-3MC-2-one (3MC-2-one 9,10-dihydrodiol) as the predominant metabolite of the potent carcinogen 3MC-2-one suggests that 3MC-2-one may be metabolically activated to a bay region 9,10-diol-7,8-epoxide, similar to the previously established metabolic activation pathways of 3MC and 1-hydroxy-3-methylcholanthrene (1-OH-3MC).

  15. Final report on the safety assessment of octoxynol-1, octoxynol-3, octoxynol-5, octoxynol-6, octoxynol-7, octoxynol-8, octoxynol-9, octoxynol-10, octoxynol-11, octoxynol-12, octoxynol-13, octoxynol-16, octoxynol-20, octoxynol-25, octoxynol-30, octoxynol-33, octoxynol-40, octoxynol-70, octoxynol-9 carboxylic acid, octoxynol-20 carboxylic acid, potassium octoxynol-12 phosphate, sodium octoxynol-2 ethane sulfonate, sodium octoxynol-2 sulfate, sodium octoxynol-6 sulfate, and sodium octoxynol-9 sulfate.

    PubMed

    Johnson, Wilbur

    2004-01-01

    Octoxynols are ethoxylated alkylphenols in which the size of the molecule is related to the number of moles of ethylene oxide used in synthesis. Reactions are performed at elevated temperature, under pressure, and in the presence of NaOH. It is possible that the synthesis may leave trace amounts of ethylene oxide, 1,4-dioxane, and unreacted C9 phenols. Octoxynols of various chain lengths as well as octoxynol salts and organic acids function in cosmetics either as surfactants--emulsifying agents, surfactants--cleansing agents, surfactant--solubilizing agents, or surfactants--hydrotropes in a wide variety of cosmetic products at concentrations ranging from 0.0008% to 25%, with most less than 5.0%. The octoxynols are chemically similar to nonoxynols, the safety of which were previously considered. Long-chain nonoxynols (9 and above) were considered safe as used, whereas short-chain nonoxynols (8 and below) were considered safe as used in rinse-off products and safe at concentrations less than 5% in leave-on formulations. Acute exposure of hamsters to Octoxynol-9 by bronchopulmonary lavage produced pneumonia, pulmonary edema, and intra-alveolar hemorrhage. Octoxynol-9 at doses over 1 g/kg was toxic in rats and in mice in acute oral toxicity studies. No significant effects were noted in short-term oral studies of Octoxynol-9 in rats, in subchronic oral studies of Octoxynol-40 in rats and dogs, or in chronic oral studies of Octoxynol-40 in rats. The intraperitoneal LD50 of Octoxynol-9 in rats and mice was around 100 mg/kg. In skin irritation studies, octoxynols ranged from nonirritating to moderately irritating. Octoxynols were not ocular irritants in one rabbit study, but in others there was ocular irritation. No immune system toxicity in CF-1 female mice was noted following the intraperitoneal injection of Octoxynol-9 followed by subcutaneous immunization with sheep red blood cells (SRBCs). Octoxynol-9 produced no humoral and cell-mediated immune responses, or

  16. Applications of GOES-8/9 data to hurricane analysis

    NASA Technical Reports Server (NTRS)

    Velden, Christopher S.

    1995-01-01

    GOES-8 was successfully launched in 1994, and has performed up to expeditions and in some cases has actually exceeded pre-launch specifications. A similar geostationary satellite, GOES-9, was launched in May of 1995. This new generation of NOAA's geostationary satellites carry a superior design and instrumentation package that allow for greater detection of meteorological features and parameters. The new GOES imager has a 5 band multispectral capability with high spatial resolution, while the sounder contains 18 thermal infrared (IR) bands plus a low resolution visible band. The imager carries a visible channel with 1 10-bit quantization and increased sampling frequency, a short-wave and long-wave window channel, and a water vapor band with a twofold increase in spatial resolution and a factor of 3 improvement in signal-to-noise over that obtained from previous GOES sensors. The advances in observing the earth's atmospheric system anticipated from these improvements are outlined in Menzel and Purdom (1994). The specific impact of this improved remote sensing capability on the analysis of tropical cyclones is discussed here.

  17. 9. Historic view, Pier 10. View to east, 1932. Photographic ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Historic view, Pier 10. View to east, 1932. Photographic copy of photo. Boston National Historical Park Archives, Charlestown Navy Yard. BOSTS 8777, USN # 271-32, 5/9/32 - Charlestown Navy Yard, Pier 10, Between Piers 9 & 11 along Mystic River on Charlestown Waterfront at eastern edge of Charlestown Navy Yard, Boston, Suffolk County, MA

  18. Excited states in ^9Li from d(^8Li,p)^9Li

    NASA Astrophysics Data System (ADS)

    Rehm, K. E.; Greene, J. P.; Henderson, D. J.; Janssens, R. V. F.; Jiang, C. L.; Moore, E. F.; Pardo, R. C.; Peterson, D.; Pieper, S. C.; Savard, G.; Schiffer, J. P.; Sinha, S.; Tang, X.; Wiringa, R. W.; Wuosmaa, A. H.; Jisonna, L.; Segel, R. E.; Paul, M.

    2004-10-01

    We have studied levels in ^9Li from the d(^8Li,p)^9Li reaction using an unstable ^8Li beam produced at the ATLAS "in-flight" production facility at Argonne National Laboratory. The ^8Li beam bombarded a solid CD2 target. Protons from the d(^8Li,p)^9Li reaction were detected at backward angles in the laboratory using segmented silicon detectors, in coincidence with forward scattered ^7,8,9Li ions. The neutron spectroscopic factors determined from the d(^8Li,p)^9Li reaction can be used as a sensitive test for modern calculations of the structure of ^9Li. Experimental proton angular distributions for low-lying levels in ^9Li will be presented and compared with theoretical predictions. Work Supported by the U. S. DOE, Office of Nuclear Physics, Contract numbers W-31-109-ENG-38 (ANL), DE-FG02-04R41320 (WMU) and DE-FG02-98ER4106 (NWU), and the Faculty Research and Creative Activities Fund, Western Michigan University (WMU).

  19. Photocopy of drawing (this photograph is an 8" x 10" ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing (this photograph is an 8" x 10" copy of an 8" x 10" negative; 1956 original architectural drawing located at Building No. 458, NAS, Pensacola, Florida) QUARTERS Q-8 FLOOR PLAN, SHEET 1 OF 1 - U.S. Naval Air Station, Captain's Quarters, Q-8 North Avenue, Pensacola, Escambia County, FL

  20. 24 CFR 10.8 - Notice of proposed rulemaking.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Notice of proposed rulemaking. 10.8 Section 10.8 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development RULEMAKING: POLICY AND PROCEDURES Procedures § 10.8 Notice of proposed rulemaking. Each notice...

  1. 40 CFR 8.10 - Cases of emergency.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Cases of emergency. 8.10 Section 8.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL IMPACT ASSESSMENT OF NONGOVERNMENTAL ACTIVITIES IN ANTARCTICA § 8.10 Cases of emergency. This part shall not apply to activities...

  2. 40 CFR 8.10 - Cases of emergency.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Cases of emergency. 8.10 Section 8.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL IMPACT ASSESSMENT OF NONGOVERNMENTAL ACTIVITIES IN ANTARCTICA § 8.10 Cases of emergency. This part shall not apply to activities...

  3. 40 CFR 8.10 - Cases of emergency.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Cases of emergency. 8.10 Section 8.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL IMPACT ASSESSMENT OF NONGOVERNMENTAL ACTIVITIES IN ANTARCTICA § 8.10 Cases of emergency. This part shall not apply to activities...

  4. 40 CFR 8.10 - Cases of emergency.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Cases of emergency. 8.10 Section 8.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL IMPACT ASSESSMENT OF NONGOVERNMENTAL ACTIVITIES IN ANTARCTICA § 8.10 Cases of emergency. This part shall not apply to activities...

  5. 30 CFR 401.8-401.10 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false 401.8-401.10 Section 401.8-401.10 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR STATE WATER RESEARCH INSTITUTE PROGRAM Designation of Institutes; Institute Programs §§ 401.8-401.10...

  6. 40 CFR 8.10 - Cases of emergency.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Cases of emergency. 8.10 Section 8.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL IMPACT ASSESSMENT OF NONGOVERNMENTAL ACTIVITIES IN ANTARCTICA § 8.10 Cases of emergency. This part shall not apply to activities...

  7. 15 CFR 8c.10 - Self-evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Self-evaluation. 8c.10 Section 8c.10... BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF COMMERCE § 8c.10 Self... handicaps or organizations representing individuals with handicaps, to participate in the...

  8. Epigenetics Europe conference. Munich, Germany, 8-9 September 2011.

    PubMed

    Jeltsch, Albert

    2011-12-01

    At the Epigenetics Europe conference in Munich, Germany, held on 8-9 September 2011, 19 speakers from different European countries were presenting novel data and concepts on molecular epigenetics. The talks were mainly focused on questions of the generation, maintenance, flexibility and erasure of DNA methylation patterns in context of other epigenetic signals like histone tail modifications and ncRNAs.

  9. Career Activities in Mathematics: Grades 7, 8, 9.

    ERIC Educational Resources Information Center

    Boise City Independent School District, ID.

    The career activities guide in mathematics, part of an Idaho State Department of Vocational Education career exploration series for grades 7, 8, and 9, is designed as supplementary material to enrich the regular curriculum. Any one activity in the guide might be used without involving any other activities. The cross-referenced index indicates…

  10. 44 CFR 9.8 - Public notice requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... HOMELAND SECURITY GENERAL FLOODPLAIN MANAGEMENT AND PROTECTION OF WETLANDS § 9.8 Public notice requirements... when proposing any action in or affecting floodplains or wetlands. (b) General. The Agency shall... having potential to affect, adversely, or be affected by floodplains or wetlands that it proposes....

  11. 44 CFR 9.8 - Public notice requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... HOMELAND SECURITY GENERAL FLOODPLAIN MANAGEMENT AND PROTECTION OF WETLANDS § 9.8 Public notice requirements... when proposing any action in or affecting floodplains or wetlands. (b) General. The Agency shall... having potential to affect, adversely, or be affected by floodplains or wetlands that it proposes....

  12. 44 CFR 9.8 - Public notice requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... HOMELAND SECURITY GENERAL FLOODPLAIN MANAGEMENT AND PROTECTION OF WETLANDS § 9.8 Public notice requirements... when proposing any action in or affecting floodplains or wetlands. (b) General. The Agency shall... having potential to affect, adversely, or be affected by floodplains or wetlands that it proposes....

  13. 44 CFR 9.8 - Public notice requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... HOMELAND SECURITY GENERAL FLOODPLAIN MANAGEMENT AND PROTECTION OF WETLANDS § 9.8 Public notice requirements... when proposing any action in or affecting floodplains or wetlands. (b) General. The Agency shall... having potential to affect, adversely, or be affected by floodplains or wetlands that it proposes....

  14. 44 CFR 9.8 - Public notice requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... HOMELAND SECURITY GENERAL FLOODPLAIN MANAGEMENT AND PROTECTION OF WETLANDS § 9.8 Public notice requirements... when proposing any action in or affecting floodplains or wetlands. (b) General. The Agency shall... having potential to affect, adversely, or be affected by floodplains or wetlands that it proposes....

  15. 47 CFR 8.9 - Other laws and considerations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRESERVING THE OPEN INTERNET § 8.9 Other laws and... Internet access service may have to address the needs of emergency communications or law enforcement... provider of broadband Internet access service to address copyright infringement or other unlawful activity....

  16. 47 CFR 8.9 - Other laws and considerations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRESERVING THE OPEN INTERNET § 8.9 Other laws and... Internet access service may have to address the needs of emergency communications or law enforcement... provider of broadband Internet access service to address copyright infringement or other unlawful activity....

  17. 47 CFR 8.9 - Other laws and considerations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRESERVING THE OPEN INTERNET § 8.9 Other laws and... Internet access service may have to address the needs of emergency communications or law enforcement... provider of broadband Internet access service to address copyright infringement or other unlawful activity....

  18. 47 CFR 8.9 - Other Laws and Considerations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRESERVING THE OPEN INTERNET § 8.9 Other Laws and... Internet access service may have to address the needs of emergency communications or law enforcement... provider of broadband Internet access service to address copyright infringement or other unlawful activity....

  19. Career Activities in Social Science: Grades 7, 8, 9.

    ERIC Educational Resources Information Center

    Boise City Independent School District, ID.

    The career activities guide in social science, part of an Idaho State Department of Vocational Education career exploration series for grades 7, 8, and 9, is designed as supplementary material to enrich the regular curriculum. Any one activity in the guide might be used without involving any other activities. The cross-referenced index indicates…

  20. Career Activities in Language Arts: Grades 7, 8, 9.

    ERIC Educational Resources Information Center

    Boise City Independent School District, ID.

    The career activities guide in language arts, part of an Idaho State Department of Vocational Education career exploration series for grades 7, 8, and 9, is designed as supplementary material to enrich the regular curriculum. Any one activity in the guide might be used without involving any other activities. The cross-referenced index indicates…

  1. 15 CFR 8.9 - Intimidatory or retaliatory acts prohibited.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... RIGHTS ACT OF 1964 General Compliance § 8.9 Intimidatory or retaliatory acts prohibited. (a) No recipient or other party subject to this part shall intimidate, threaten, coerce, or discriminate against, any person for the purpose of interfering with any right or privilege secured by section 601 of the Act...

  2. Career Activities in Science: Grades 7, 8, 9.

    ERIC Educational Resources Information Center

    Boise City Independent School District, ID.

    The career activities guide in science, part of an Idaho State Department of Vocational Education career exploration series for grades 7, 8, and 9, is designed as supplementary material to enrich the regular curriculum. Any one activity in the guide might be used without involving any other activities. The cross-referenced index indicates grades,…

  3. 19 CFR 10.9 - Articles exported for processing.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 1 2013-04-01 2013-04-01 false Articles exported for processing. 10.9 Section 10... THE TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. General Provisions Articles Exported and Returned § 10.9 Articles exported for processing. (a) Except as otherwise provided for in...

  4. 19 CFR 10.9 - Articles exported for processing.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 1 2014-04-01 2014-04-01 false Articles exported for processing. 10.9 Section 10... THE TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. General Provisions Articles Exported and Returned § 10.9 Articles exported for processing. (a) Except as otherwise provided for in...

  5. 19 CFR 10.9 - Articles exported for processing.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 1 2011-04-01 2011-04-01 false Articles exported for processing. 10.9 Section 10... THE TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. General Provisions Articles Exported and Returned § 10.9 Articles exported for processing. (a) Except as otherwise provided for in...

  6. 19 CFR 10.9 - Articles exported for processing.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 1 2012-04-01 2012-04-01 false Articles exported for processing. 10.9 Section 10... THE TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. General Provisions Articles Exported and Returned § 10.9 Articles exported for processing. (a) Except as otherwise provided for in...

  7. 19 CFR 10.9 - Articles exported for processing.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Articles exported for processing. 10.9 Section 10... Exported and Returned § 10.9 Articles exported for processing. (a) Except as otherwise provided for in this... returned after having been exported for further processing and which are claimed to be subject to duty...

  8. AAV-8 is more efficient than AAV-9 in transducing neonatal dog heart.

    PubMed

    Pan, Xiufang; Yue, Yongping; Zhang, Keqing; Hakim, Chady H; Kodippili, Kasun; McDonald, Thomas; Duan, Dongsheng

    2015-04-01

    Adeno-associated virus serotype-8 and 9 (AAV-8 and 9) are the leading candidate vectors to test bodywide neonatal muscle gene therapy in large mammals. We have previously shown that systemic injection of 2-2.5×10(14) viral genome (vg) particles/kg of AAV-9 resulted in widespread skeletal muscle gene transfer in newborn dogs. However, nominal transduction was observed in the heart. In contrast, robust expression was achieved in both skeletal muscle and heart in neonatal dogs with 7.14-9.06×10(14) vg particles/kg of AAV-8. To determine whether superior cardiac transduction of AAV-8 is because of the higher vector dose, we delivered 6.14×10(14) and 9.65×10(14) vg particles/kg of AAV-9 to newborn puppies via the jugular vein. Transduction was examined 2.5 months later. Consistent with our previous reports, we observed robust bodywide transduction in skeletal muscle. However, increased AAV dose only moderately improved heart transduction. It never reached the level achieved by AAV-8. Our results suggest that differential cardiac transduction by AAV-8 and AAV-9 is likely because of the intrinsic property of the viral capsid rather than the vector dose.

  9. Global variation in CYP2C8–CYP2C9 functional haplotypes

    PubMed Central

    Speed, William C; Kang, Soonmo Peter; Tuck, David P; Harris, Lyndsay N; Kidd, Kenneth K

    2009-01-01

    We have studied the global frequency distributions of 10 single nucleotide polymorphisms (SNPs) across 132 kb of CYP2C8 and CYP2C9 in ∼2500 individuals representing 45 populations. Five of the SNPs were in noncoding sequences; the other five involved the more common missense variants (four in CYP2C8, one in CYP2C9) that change amino acids in the gene products. One haplotype containing two CYP2C8 coding variants and one CYP2C9 coding variant reaches an average frequency of 10% in Europe; a set of haplotypes with a different CYP2C8 coding variant reaches 17% in Africa. In both cases these haplotypes are found in other regions of the world at <1%. This considerable geographic variation in haplotype frequencies impacts the interpretation of CYP2C8/CYP2C9 association studies, and has pharmacogenomic implications for drug interactions. PMID:19381162

  10. Probes for narcotic receptor mediated phenomena. 46.° N-Substituted-2,3,4,9,10,10a-hexahydro-1H-1,4a-(epiminoethano)phenanthren-6- and 8-ols - carbocyclic relatives of f-oxide bridged phenylmorphans

    PubMed Central

    Li, Fuying; Deck, Jason A.; Dersch, Christina M.; Rothman, Richard B.; Deschamps, Jeffrey R.; Jacobson, Arthur E.; Rice, Kenner C.

    2012-01-01

    Oxide-bridged phenylmorphans were conceptualized as topologically distinct, structurally rigid ligands with 3-dimensional shapes that could not be appreciably modified on interaction with opioid receptors. An enantiomer of the N-phenethyl-substituted ortho-f isomer was found to have high affinity for the μ-receptor (Ki = 7 nM) and was about four times more potent than naloxone as an antagonist. In order to examine the effect of introduction of a small amount of flexibility into these molecules, we have replaced the rigid 5-membered oxide ring with a more flexible 6-membered carbon ring. Synthesis of the new N-phenethyl-substituted tricyclic N-substituted-2,3,4,9,10,10a-hexahydro-1H-1,4a-(epiminoethano)phenanthren-6- and 8-ols resulted in a two carbon-bridged relative of the f-isomers, the dihydrofuran ring was replaced by a cyclohexene ring. The carbocyclic compounds had much higher affinity and greater selectivity for the μ-receptor than the f-oxide-bridged phenylmorphans. They were also much more potent μ-antagonists, with activities comparable to naltrexone in the [35S]GTPγS assay. PMID:23168379

  11. Crystal structure of (1S,3R,8R,10S)-2,2-di­chloro-10-hy­droxy-3,7,7,10-tetra­methyl­tri­cyclo­[6.4.0.01,3]dodecan-9-one

    PubMed Central

    Benzalim, Ahmed; Auhmani, Aziz; Ait Itto, My Youssef; Daran, Jean-Claude; Abdelwahed, Auhmani

    2016-01-01

    The asymmetric unit of the title compound, C16H24Cl2O2, contains two independent mol­ecules (A and B) which are built from three fused rings, viz. a seven-membered heptane ring, a six-membered cyclo­hexyl ring bearing a ketone and an alcohol group, and a cyclo­propane ring bearing two Cl atoms. In the crystal, the two mol­ecules are linked via two O—H⋯O hydrogen bonds, forming an A–B dimer with an R 2 2(10) ring motif. The A mol­ecules of these dimers are linked via a C—H⋯O hydrogen bond, forming chains propagating along the a-axis direction. Both mol­ecules have the same absolute configuration, i.e. 1S,3R,8R,10S, which is based on the synthetic pathway and further confirmed by resonant scattering [Flack parameter = 0.03 (5)]. PMID:27308024

  12. Rate 8/9 coded 8-PSK system for downlink applications

    NASA Technical Reports Server (NTRS)

    Fang, Russell; Kappes, Mark; Miller, Susan

    1992-01-01

    An advanced Coded Trellis Modulation (CTM) System which achieves a 2 bits/s/Hz bandwidth efficiency at an information rate of 200 Mbit/s while minimizing satellite power requirements, was developed for downlink earth station applications. The CTM system employs a high-speed rate 8/9 convolutional code with Viterbi decoding and an 8-Phase Shift Keying (PSK) modem. The minimum Euclidean distance between the modulated waveforms corresponding to the information sequences are maximized in order to maximize the noise immunity of the system. Nyquist filters with a square-root of 40 percent roll-off are used at the transmit and receive sides of the modem in order to minimize intersymbol interference, adjacent channel interference, and distortion at the nonlinear satellite power amplifier. The use of a coded system here also minimizes the effects of co-channel interference. The developed performance of the hardware system was measured to achieve within 1.5 dB from theory at a bit error rate of 5 x 10(exp -7) over an additive white Gaussian noise channel.

  13. S100A8/A9 is associated with estrogen receptor loss in breast cancer

    PubMed Central

    BAO, YI; WANG, ANTAO; MO, JUANFEN

    2016-01-01

    S100A8 and S100A9 are calcium-binding proteins that are secreted primarily by granulocytes and monocytes, and are upregulated during the inflammatory response. S100A8 and S100A9 have been identified to be expressed by epithelial cells involved in malignancy. In the present study, the transcriptional levels of S100A8 and S100A9 were investigated in various subtypes of breast cancer (BC), and the correlation with estrogen receptor 1 (ESR1) and GATA binding protein 3 (GATA3) gene expression was evaluated using microarray datasets. The expression of S100A8 and S100A9 in BC cells was assessed by reverse transcription-polymerase chain reaction (RT-PCR). The regulation of ESR1 and GATA3 by administration of recombinant S100A8/A9 was examined in the BC MCF-7 cell line using quantitative (q)PCR. The association between S100A8 and S100A9 and overall survival (OS) was investigated in GeneChip® data of BC. The expression levels of S100A8 and S100A9 were higher in human epidermal growth factor receptor 2 (Her2)-amplified and basal-like BC. The messenger (m)RNA levels of S100A8 and S100A9 were inversely correlated with ESR1 and GATA3 expression. S100A8/A9 induced a 10-fold decrease in the mRNA levels of ESR1 in MCF-7 cells. Poor OS was associated with high expression levels of S100A9, but not with high expression levels of S100A8 in BC. In conclusion, strong expression and secretion of S100A8/A9 may be associated with the loss of estrogen receptor in BC, and may be involved in the poor prognosis of Her2+/basal-like subtypes of BC. PMID:26998104

  14. Summary of Synoptic Meteorological Observations (SSMO), Central American Coastal Marine Areas, West Coast. Volume 2. Area 6 - Manzanillo SE, Area 7 - Acapulco South, Area 8 - Gulf of Tehuantepec, Area 9 - Guatemala SW Coast, Area 10 - Nicaragua SW Coast, Area 11 - Punta Burica

    DTIC Science & Technology

    1981-02-01

    AREA COD ACAPULCC $ CLIP PEC1411TGE FR[CU~kCY,*OF ¥I:0 SF1EO BY HOUR IG Tl HOUR CALM 1 -3 4-10 11-21 22-33 34൷ 44- MEAN FRED oeS * S$ a . D* 2z, 6 o...590( r45 .47 :38(0 t0 vOCo SO sIo 33 8. . ! t (3:2 C5 .9 0 :0 .0 3.4:0 .3. 8 0 . 3 .0 .5 3. 3- .3 C 7 . 0 . .0 2.2 . 23 . 0 .0 .0 2. 171 0 c C . .3 .8

  15. Photocopy of drawing (this photograph is an 8" x 10" ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing (this photograph is an 8" x 10" copy of an 8" x 10" negative; 1933 original architectural drawing located at Building No. 458, NAS Pensacola, Florida) QUARTERS M, ALTERATIONS TO NORTHEAST PORCH AND LOCATION OF RADIATORS - U.S. Naval Air Station, Captain's Quarters, Q-8 North Avenue, Pensacola, Escambia County, FL

  16. Photocopy of drawing (this photograph is an 8" x 10" ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing (this photograph is an 8" x 10" copy of an 8" x 10" negative; 1946 original architectural drawing located at Building No. 458, NAS Pensacola, Florida) QUARTERS "M," REHABILITATION OF QUARTERS M, FLOOR PLAN, SHEET 1 OF 4 - U.S. Naval Air Station, Captain's Quarters, Q-8 North Avenue, Pensacola, Escambia County, FL

  17. Photocopy of drawing (this photograph is an 8" x 10" ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing (this photograph is an 8" x 10" copy of an 8" x 10" negative; microfilm of 1908 architectural drawing located at National Archives and Records Administration at College Park, Maryland NARA) PLUMBING ARRANGEMENT FOR QUARTERS M AND K, SHEET 1 OF 4 - U.S. Naval Air Station, Captain's Quarters, Q-8 North Avenue, Pensacola, Escambia County, FL

  18. Photocopy of drawing (this photograph is an 8" x 10" ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing (this photograph is an 8" x 10" copy of an 8" x 10" negative; microfilm of 1935 architectural drawing located at NARA) QUARTERS "M" FLOOR PLAN, SHEET 1 OF 1 - U.S. Naval Air Station, Captain's Quarters, Q-8 North Avenue, Pensacola, Escambia County, FL

  19. 9 CFR 149.8 - Program fees and charges.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... rate: Per hour $84.00 Per quarter hour 21.00 Per service minimum fee 25.00 Table 2—Overtime Rates for... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Program fees and charges. 149.8... and holidays: Per hour $100.00 Per quarter hour 25.00 Premium hourly rate for Sundays: Per hour...

  20. 9 CFR 149.8 - Program fees and charges.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... rate: Per hour $84.00 Per quarter hour 21.00 Per service minimum fee 25.00 Table 2—Overtime Rates for... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Program fees and charges. 149.8... and holidays: Per hour $100.00 Per quarter hour 25.00 Premium hourly rate for Sundays: Per hour...