Science.gov

Sample records for 8-10 hz discontinuities

  1. 38 CFR 8.10 - How paid.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false How paid. 8.10 Section 8.10 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS NATIONAL SERVICE LIFE INSURANCE Dividends § 8.10 How paid. (a) Except as hereinafter provided in this paragraph, a National Service Life Insurance policy shall participate...

  2. 41 CFR 51-8.10 - Appeals.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 41 Public Contracts and Property Management 1 2012-07-01 2009-07-01 true Appeals. 51-8.10 Section... MATERIALS § 51-8.10 Appeals. (a) An appeal to the Chairperson of any denial, in whole or in part, of a... denial. (b) The Chairperson shall make a determination with respect to any appeal within 20...

  3. 41 CFR 51-8.10 - Appeals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 41 Public Contracts and Property Management 1 2014-07-01 2014-07-01 false Appeals. 51-8.10 Section... MATERIALS § 51-8.10 Appeals. (a) An appeal to the Chairperson of any denial, in whole or in part, of a... denial. (b) The Chairperson shall make a determination with respect to any appeal within 20...

  4. 41 CFR 51-8.10 - Appeals.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 1 2013-07-01 2013-07-01 false Appeals. 51-8.10 Section... MATERIALS § 51-8.10 Appeals. (a) An appeal to the Chairperson of any denial, in whole or in part, of a... denial. (b) The Chairperson shall make a determination with respect to any appeal within 20...

  5. 40 CFR 8.10 - Cases of emergency.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Cases of emergency. 8.10 Section 8.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL IMPACT ASSESSMENT OF NONGOVERNMENTAL ACTIVITIES IN ANTARCTICA § 8.10 Cases of emergency. This part shall not apply to activities...

  6. 40 CFR 8.10 - Cases of emergency.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Cases of emergency. 8.10 Section 8.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL IMPACT ASSESSMENT OF NONGOVERNMENTAL ACTIVITIES IN ANTARCTICA § 8.10 Cases of emergency. This part shall not apply to activities taken in cases of emergency relating...

  7. 24 CFR 8.10 - General prohibitions against employment discrimination.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... employment discrimination. 8.10 Section 8.10 Housing and Urban Development Office of the Secretary... prohibitions against employment discrimination. (a) No qualified individual with handicaps shall, solely on the basis of handicap, be subjected to discrimination in employment under any program or activity...

  8. 40 CFR 8.10 - Cases of emergency.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Cases of emergency. 8.10 Section 8.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL IMPACT ASSESSMENT OF... in cases of emergency relating to the safety of human life or of ships, aircraft, equipment...

  9. 24 CFR 8.10 - General prohibitions against employment discrimination.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... employment discrimination. 8.10 Section 8.10 Housing and Urban Development Office of the Secretary... prohibitions against employment discrimination. (a) No qualified individual with handicaps shall, solely on the basis of handicap, be subjected to discrimination in employment under any program or activity...

  10. 29 CFR 8.10 - Filing and service.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... (e) Service upon the Department of Labor and other interested parties. A copy of all documents filed... 29 Labor 1 2010-07-01 2010-07-01 true Filing and service. 8.10 Section 8.10 Labor Office of the Secretary of Labor PRACTICE BEFORE THE ADMINISTRATIVE REVIEW BOARD WITH REGARD TO FEDERAL SERVICE...

  11. 29 CFR 8.10 - Filing and service.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .... (e) Service upon the Department of Labor and other interested parties. A copy of all documents filed... 29 Labor 1 2014-07-01 2013-07-01 true Filing and service. 8.10 Section 8.10 Labor Office of the Secretary of Labor PRACTICE BEFORE THE ADMINISTRATIVE REVIEW BOARD WITH REGARD TO FEDERAL SERVICE...

  12. 29 CFR 8.10 - Filing and service.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .... (e) Service upon the Department of Labor and other interested parties. A copy of all documents filed... 29 Labor 1 2013-07-01 2013-07-01 false Filing and service. 8.10 Section 8.10 Labor Office of the Secretary of Labor PRACTICE BEFORE THE ADMINISTRATIVE REVIEW BOARD WITH REGARD TO FEDERAL SERVICE...

  13. 29 CFR 8.10 - Filing and service.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    .... (e) Service upon the Department of Labor and other interested parties. A copy of all documents filed... 29 Labor 1 2012-07-01 2012-07-01 false Filing and service. 8.10 Section 8.10 Labor Office of the Secretary of Labor PRACTICE BEFORE THE ADMINISTRATIVE REVIEW BOARD WITH REGARD TO FEDERAL SERVICE...

  14. 29 CFR 8.10 - Filing and service.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... (e) Service upon the Department of Labor and other interested parties. A copy of all documents filed... 29 Labor 1 2011-07-01 2011-07-01 false Filing and service. 8.10 Section 8.10 Labor Office of the Secretary of Labor PRACTICE BEFORE THE ADMINISTRATIVE REVIEW BOARD WITH REGARD TO FEDERAL SERVICE...

  15. Coping Strategies at the Ages 8, 10 and 12

    ERIC Educational Resources Information Center

    Zsolnai, Aniko; Kasik, Laszlo; Braunitzer, Gabor

    2015-01-01

    The aim of the cross-sectional study was to reveal what coping strategies 8, 10- and 12-year-old Hungarian students (N?=?167) use in situations that are frustrating, either for themselves or their peers. The coping strategies in school situations were assessed by our own questionnaires. The instrument enables the investigation of the following…

  16. Cultural Discontinuities and Schooling.

    ERIC Educational Resources Information Center

    Ogbu, John U.

    1982-01-01

    Attempts to define the cultural discontinuity (between schools and students) hypothesis by distinguishing between universal, primary, and secondary discontinuities. Suggests that each of these is associated with a distinct type of school problem, and that secondary cultural discontinuities commonly affect minority students in the United States.…

  17. Modern Regression Discontinuity Analysis

    ERIC Educational Resources Information Center

    Bloom, Howard S.

    2012-01-01

    This article provides a detailed discussion of the theory and practice of modern regression discontinuity (RD) analysis for estimating the effects of interventions or treatments. Part 1 briefly chronicles the history of RD analysis and summarizes its past applications. Part 2 explains how in theory an RD analysis can identify an average effect of…

  18. 26 CFR 5c.168(f)(8)-10 - Leases between related parties. [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 14 2010-04-01 2010-04-01 false Leases between related parties. 5c.168(f)(8)-10 Section 5c.168(f)(8)-10 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) TEMPORARY INCOME TAX REGULATIONS UNDER THE ECONOMIC RECOVERY TAX ACT OF 1981 §...

  19. Substrate specificity of papain dynamic structures for peptides consisting of 8-10 GLY residues

    NASA Astrophysics Data System (ADS)

    Nishiyama, Katsuhiko

    2011-01-01

    We investigated the substrate specificity of papain dynamic structures for peptides of 8-10 glycine residues (8-10GLY) via molecular dynamics and docking simulations. The substrate specificity of papain for 8-10GLY fluctuated considerably with time. There were several residues that were different among those that had a significant impact on binding (RESIDUES_IMPACT) with 10GLY, 9GLY, and 8GLY. Modification of these different residues should allow for control of substrate specificity, providing a framework for modifying substrate specificity in papain and other enzymes.

  20. Mingus Discontinuous Multiphysics

    2014-05-13

    Mingus provides hybrid coupled local/non-local mechanics analysis capabilities that extend several traditional methods to applications with inherent discontinuities. Its primary features include adaptations of solid mechanics, fluid dynamics and digital image correlation that naturally accommodate dijointed data or irregular solution fields by assimilating a variety of discretizations (such as control volume finite elements, peridynamics and meshless control point clouds). The goal of this software is to provide an analysis framework form multiphysics engineering problems withmore » an integrated image correlation capability that can be used for experimental validation and model« less

  1. Discontinuous ephemeral streams

    NASA Astrophysics Data System (ADS)

    Bull, William B.

    1997-07-01

    Many ephemeral streams in western North America flowed over smooth valley floors before transformation from shallow discontinuous channels into deep arroyos. These inherently unstable streams of semiarid regions are sensitive to short-term climatic changes, and to human impacts, because hillslopes supply abundant sediment to infrequent large streamflow events. Discontinuous ephemeral streams appear to be constantly changing as they alternate between two primary modes of operation; either aggradation or degradation may become dominant. Attainment of equilibrium conditions is brief. Disequilibrium is promoted by channel entrenchment that causes the fall of local base level, and by deposition of channel fans that causes the rise of local base level. These opposing base-level processes in adjacent reaches are maintained by self-enhancing feedback mechanisms. The threshold between erosion and deposition is crossed when aggradational or degradational reaches shift upstream or downstream. Extension of entrenched reaches into channel fans tends to create continuous arroyos. Upvalley migration of fan apexes tends to create depositional valley floors with few stream channels. Less than 100 years is required for arroyo cutting, but more than 500 years is required for complete aggradation of entrenched stream channels and valley floors. Discontinuous ephemeral streams have a repetitive sequence of streamflow characteristics that is as distinctive as sequences of meander bends or braided gravel bars in perennial rivers. The sequence changes from degradation to aggradation — headcuts concentrate sheetflow, a single trunk channel conveys flow to the apex of a channel fan, braided distributary channels end in an area of diverging sheetflow, and converging sheetflow drains to headcuts. The sequence is repeated at intervals ranging from 15 m for small streams to more than 10 km for large streams. Lithologic controls on the response of discontinuous ephemeral streams include: (1

  2. Mingus Discontinuous Multiphysics

    SciTech Connect

    Pat Notz, Dan Turner

    2014-05-13

    Mingus provides hybrid coupled local/non-local mechanics analysis capabilities that extend several traditional methods to applications with inherent discontinuities. Its primary features include adaptations of solid mechanics, fluid dynamics and digital image correlation that naturally accommodate dijointed data or irregular solution fields by assimilating a variety of discretizations (such as control volume finite elements, peridynamics and meshless control point clouds). The goal of this software is to provide an analysis framework form multiphysics engineering problems with an integrated image correlation capability that can be used for experimental validation and model

  3. Kinematics of Strong Discontinuities

    NASA Technical Reports Server (NTRS)

    Peterson, K.; Nguyen, G.; Sulsky, D.

    2006-01-01

    Synthetic Aperture Radar (SAR) provides a detailed view of the Arctic ice cover. When processed with the RADARSAT Geophysical Processor System (RGPS), it provides estimates of sea ice motion and deformation over large regions of the Arctic for extended periods of time. The deformation is dominated by the appearance of linear kinematic features that have been associated with the presence of leads. The RGPS deformation products are based on the assumption that the displacement and velocity are smooth functions of the spatial coordinates. However, if the dominant deformation of multiyear ice results from the opening, closing and shearing of leads, then the displacement and velocity can be discontinuous. This presentation discusses the kinematics associated with strong discontinuities that describe possible jumps in displacement or velocity. Ice motion from SAR data are analyzed using this framework. It is assumed that RGPS cells deform due to the presence of a lead. The lead orientation is calculated to optimally account for the observed deformation. It is shown that almost all observed deformation can be represented by lead opening and shearing. The procedure used to reprocess motion data to account for leads will be described and applied to regions of the Beaufort Sea. The procedure not only provides a new view of ice deformation, it can be used to obtain information about the presence of leads for initialization and/or validation of numerical simulations.

  4. CD44 Splice Variant v8-10 as a Marker of Serous Ovarian Cancer Prognosis.

    PubMed

    Sosulski, Amanda; Horn, Heiko; Zhang, Lihua; Coletti, Caroline; Vathipadiekal, Vinod; Castro, Cesar M; Birrer, Michael J; Nagano, Osamu; Saya, Hideyuki; Lage, Kasper; Donahoe, Patricia K; Pépin, David

    2016-01-01

    CD44 is a transmembrane hyaluronic acid receptor gene that encodes over 100 different tissue-specific protein isoforms. The most ubiquitous, CD44 standard, has been used as a cancer stem cell marker in ovarian and other cancers. Expression of the epithelial CD44 variant containing exons v8-10 (CD44v8-10) has been associated with more chemoresistant and metastatic tumors in gastrointestinal and breast cancers, but its role in ovarian cancer is unknown; we therefore investigated its use as a prognostic marker in this disease. The gene expression profiles of 254 tumor samples from The Cancer Genome Atlas RNAseqV2 were analyzed for the presence of CD44 isoforms. A trend for longer survival was observed in patients with high expression of CD44 isoforms that include exons v8-10. Immunohistochemical (IHC) analysis of tumors for presence of CD44v8-10 was performed on an independent cohort of 210 patients with high-grade serous ovarian cancer using a tumor tissue microarray. Patient stratification based on software analysis of staining revealed a statistically significant increase in survival in patients with the highest levels of transmembrane protein expression (top 10 or 20%) compared to those with the lowest expression (bottom 10 and 20%) (p = 0.0181, p = 0.0262 respectively). Expression of CD44v8-10 in primary ovarian cancer cell lines was correlated with a predominantly epithelial phenotype characterized by high expression of epithelial markers and low expression of mesenchymal markers by qPCR, Western blot, and IHC. Conversely, detection of proteolytically cleaved and soluble extracellular domain of CD44v8-10 in patient ascites samples was correlated with significantly worse prognosis (p<0.05). Therefore, presence of transmembrane CD44v8-10 on the surface of primary tumor cells may be a marker of a highly epithelial tumor with better prognosis while enzymatic cleavage of CD44v8-10, as detected by presence of the soluble extracellular domain in ascites fluid, may be

  5. CD44 Splice Variant v8-10 as a Marker of Serous Ovarian Cancer Prognosis

    PubMed Central

    Zhang, Lihua; Coletti, Caroline; Vathipadiekal, Vinod; Castro, Cesar M.; Birrer, Michael J.; Nagano, Osamu; Saya, Hideyuki; Lage, Kasper; Donahoe, Patricia K.; Pépin, David

    2016-01-01

    CD44 is a transmembrane hyaluronic acid receptor gene that encodes over 100 different tissue-specific protein isoforms. The most ubiquitous, CD44 standard, has been used as a cancer stem cell marker in ovarian and other cancers. Expression of the epithelial CD44 variant containing exons v8-10 (CD44v8-10) has been associated with more chemoresistant and metastatic tumors in gastrointestinal and breast cancers, but its role in ovarian cancer is unknown; we therefore investigated its use as a prognostic marker in this disease. The gene expression profiles of 254 tumor samples from The Cancer Genome Atlas RNAseqV2 were analyzed for the presence of CD44 isoforms. A trend for longer survival was observed in patients with high expression of CD44 isoforms that include exons v8-10. Immunohistochemical (IHC) analysis of tumors for presence of CD44v8-10 was performed on an independent cohort of 210 patients with high-grade serous ovarian cancer using a tumor tissue microarray. Patient stratification based on software analysis of staining revealed a statistically significant increase in survival in patients with the highest levels of transmembrane protein expression (top 10 or 20%) compared to those with the lowest expression (bottom 10 and 20%) (p = 0.0181, p = 0.0262 respectively). Expression of CD44v8-10 in primary ovarian cancer cell lines was correlated with a predominantly epithelial phenotype characterized by high expression of epithelial markers and low expression of mesenchymal markers by qPCR, Western blot, and IHC. Conversely, detection of proteolytically cleaved and soluble extracellular domain of CD44v8-10 in patient ascites samples was correlated with significantly worse prognosis (p<0.05). Therefore, presence of transmembrane CD44v8-10 on the surface of primary tumor cells may be a marker of a highly epithelial tumor with better prognosis while enzymatic cleavage of CD44v8-10, as detected by presence of the soluble extracellular domain in ascites fluid, may be

  6. Biotransformation of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) by denitrifying Pseudomonas sp. strain FA1.

    PubMed

    Bhushan, Bharat; Paquet, Louise; Spain, Jim C; Hawari, Jalal

    2003-09-01

    The microbial and enzymatic degradation of a new energetic compound, 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20), is not well understood. Fundamental knowledge about the mechanism of microbial degradation of CL-20 is essential to allow the prediction of its fate in the environment. In the present study, a CL-20-degrading denitrifying strain capable of utilizing CL-20 as the sole nitrogen source, Pseudomonas sp. strain FA1, was isolated from a garden soil. Studies with intact cells showed that aerobic conditions were required for bacterial growth and that anaerobic conditions enhanced CL-20 biotransformation. An enzyme(s) involved in the initial biotransformation of CL-20 was shown to be membrane associated and NADH dependent, and its expression was up-regulated about 2.2-fold in CL-20-induced cells. The rates of CL-20 biotransformation by the resting cells and the membrane-enzyme preparation were 3.2 +/- 0.1 nmol h(-1) mg of cell biomass(-1) and 11.5 +/- 0.4 nmol h(-1) mg of protein(-1), respectively, under anaerobic conditions. In the membrane-enzyme-catalyzed reactions, 2.3 nitrite ions (NO(2)(-)), 1.5 molecules of nitrous oxide (N(2)O), and 1.7 molecules of formic acid (HCOOH) were produced per reacted CL-20 molecule. The membrane-enzyme preparation reduced nitrite to nitrous oxide under anaerobic conditions. A comparative study of native enzymes, deflavoenzymes, and a reconstituted enzyme(s) and their subsequent inhibition by diphenyliodonium revealed that biotransformation of CL-20 is catalyzed by a membrane-associated flavoenzyme. The latter catalyzed an oxygen-sensitive one-electron transfer reaction that caused initial N denitration of CL-20. PMID:12957905

  7. Biotransformation of 2,4,6,8,10,12-Hexanitro-2,4,6,8,10,12-Hexaazaisowurtzitane (CL-20) by Denitrifying Pseudomonas sp. Strain FA1

    PubMed Central

    Bhushan, Bharat; Paquet, Louise; Spain, Jim C.; Hawari, Jalal

    2003-01-01

    The microbial and enzymatic degradation of a new energetic compound, 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20), is not well understood. Fundamental knowledge about the mechanism of microbial degradation of CL-20 is essential to allow the prediction of its fate in the environment. In the present study, a CL-20-degrading denitrifying strain capable of utilizing CL-20 as the sole nitrogen source, Pseudomonas sp. strain FA1, was isolated from a garden soil. Studies with intact cells showed that aerobic conditions were required for bacterial growth and that anaerobic conditions enhanced CL-20 biotransformation. An enzyme(s) involved in the initial biotransformation of CL-20 was shown to be membrane associated and NADH dependent, and its expression was up-regulated about 2.2-fold in CL-20-induced cells. The rates of CL-20 biotransformation by the resting cells and the membrane-enzyme preparation were 3.2 ± 0.1 nmol h−1 mg of cell biomass−1 and 11.5 ± 0.4 nmol h−1 mg of protein−1, respectively, under anaerobic conditions. In the membrane-enzyme-catalyzed reactions, 2.3 nitrite ions (NO2−), 1.5 molecules of nitrous oxide (N2O), and 1.7 molecules of formic acid (HCOOH) were produced per reacted CL-20 molecule. The membrane-enzyme preparation reduced nitrite to nitrous oxide under anaerobic conditions. A comparative study of native enzymes, deflavoenzymes, and a reconstituted enzyme(s) and their subsequent inhibition by diphenyliodonium revealed that biotransformation of CL-20 is catalyzed by a membrane-associated flavoenzyme. The latter catalyzed an oxygen-sensitive one-electron transfer reaction that caused initial N denitration of CL-20. PMID:12957905

  8. Spectral methods for discontinuous problems

    NASA Technical Reports Server (NTRS)

    Abarbanel, S.; Gottlieb, D.; Tadmor, E.

    1985-01-01

    Spectral methods yield high-order accuracy even when applied to problems with discontinuities, though not in the sense of pointwise accuracy. Two different procedures are presented which recover pointwise accurate approximations from the spectral calculations.

  9. Regression Discontinuity Designs in Epidemiology

    PubMed Central

    Moscoe, Ellen; Mutevedzi, Portia; Newell, Marie-Louise; Bärnighausen, Till

    2014-01-01

    When patients receive an intervention based on whether they score below or above some threshold value on a continuously measured random variable, the intervention will be randomly assigned for patients close to the threshold. The regression discontinuity design exploits this fact to estimate causal treatment effects. In spite of its recent proliferation in economics, the regression discontinuity design has not been widely adopted in epidemiology. We describe regression discontinuity, its implementation, and the assumptions required for causal inference. We show that regression discontinuity is generalizable to the survival and nonlinear models that are mainstays of epidemiologic analysis. We then present an application of regression discontinuity to the much-debated epidemiologic question of when to start HIV patients on antiretroviral therapy. Using data from a large South African cohort (2007–2011), we estimate the causal effect of early versus deferred treatment eligibility on mortality. Patients whose first CD4 count was just below the 200 cells/μL CD4 count threshold had a 35% lower hazard of death (hazard ratio = 0.65 [95% confidence interval = 0.45–0.94]) than patients presenting with CD4 counts just above the threshold. We close by discussing the strengths and limitations of regression discontinuity designs for epidemiology. PMID:25061922

  10. Mixing of discontinuously deforming media

    NASA Astrophysics Data System (ADS)

    Smith, L. D.; Rudman, M.; Lester, D. R.; Metcalfe, G.

    2016-02-01

    Mixing of materials is fundamental to many natural phenomena and engineering applications. The presence of discontinuous deformations—such as shear banding or wall slip—creates new mechanisms for mixing and transport beyond those predicted by classical dynamical systems theory. Here, we show how a novel mixing mechanism combining stretching with cutting and shuffling yields exponential mixing rates, quantified by a positive Lyapunov exponent, an impossibility for systems with cutting and shuffling alone or bounded systems with stretching alone, and demonstrate it in a fluid flow. While dynamical systems theory provides a framework for understanding mixing in smoothly deforming media, a theory of discontinuous mixing is yet to be fully developed. New methods are needed to systematize, explain, and extrapolate measurements on systems with discontinuous deformations. Here, we investigate "webs" of Lagrangian discontinuities and show that they provide a template for the overall transport dynamics. Considering slip deformations as the asymptotic limit of increasingly localised smooth shear, we also demonstrate exactly how some of the new structures introduced by discontinuous deformations are analogous to structures in smoothly deforming systems.

  11. Mixing of discontinuously deforming media.

    PubMed

    Smith, L D; Rudman, M; Lester, D R; Metcalfe, G

    2016-02-01

    Mixing of materials is fundamental to many natural phenomena and engineering applications. The presence of discontinuous deformations-such as shear banding or wall slip-creates new mechanisms for mixing and transport beyond those predicted by classical dynamical systems theory. Here, we show how a novel mixing mechanism combining stretching with cutting and shuffling yields exponential mixing rates, quantified by a positive Lyapunov exponent, an impossibility for systems with cutting and shuffling alone or bounded systems with stretching alone, and demonstrate it in a fluid flow. While dynamical systems theory provides a framework for understanding mixing in smoothly deforming media, a theory of discontinuous mixing is yet to be fully developed. New methods are needed to systematize, explain, and extrapolate measurements on systems with discontinuous deformations. Here, we investigate "webs" of Lagrangian discontinuities and show that they provide a template for the overall transport dynamics. Considering slip deformations as the asymptotic limit of increasingly localised smooth shear, we also demonstrate exactly how some of the new structures introduced by discontinuous deformations are analogous to structures in smoothly deforming systems. PMID:26931594

  12. Synthesis of 2,4,8,10-tetroxaspiro5,5undecane

    NASA Technical Reports Server (NTRS)

    Poshkus, A. C. (Inventor)

    1985-01-01

    Pentaerythritol is converted to its diformal, 2,4,8,10-tetroxaspirol5.5undecane, by heating it to a temperature within the range of about 110 to 150 C, for a period of up to 10 minutes, in the presence of a slight excess of paraformaldehyde and of a catalytic quantity of an acid catalyst such as sulfuric acid. The reaction may be carried out in two steps, by forming first the monoformal, then the diformal. In any case, total reaction time is about 10 minutes, and yield of diformal are greater than 90%. Previous processes require hours or days, and often, tedious operating procedures.

  13. Phase unwrapping using discontinuity optimization

    SciTech Connect

    Flynn, T.J.

    1998-03-01

    In SAR interferometry, the periodicity of the phase must be removed using two-dimensional phase unwrapping. The goal of the procedure is to find a smooth surface in which large spatial phase differences, called discontinuities, are restricted to places where their presence is reasonable. The pioneering work of Goldstein et al. identified points of local unwrap inconsistency called residues, which must be connected by discontinuities. This paper presents an overview of recent work that treats phase unwrapping as a discrete optimization problem with the constraint that residues must be connected. Several algorithms use heuristic methods to reduce the total number of discontinuities. Constantini has introduced the weighted sum of discontinuity magnitudes as a criterion of unwrap error and shown how algorithms from optimization theory are used to minimize it. Pixels of low quality are given low weight to guide discontinuities away from smooth, high-quality regions. This method is generally robust, but if noise is severe it underestimates the steepness of slopes and the heights of peaks. This problem is mitigated by subtracting (modulo 2{pi}) a smooth estimate of the unwrapped phase from the data, then unwrapping the resulting residual phase. The unwrapped residual is added to the smooth estimate to produce the final unwrapped phase. The estimate can be computed by lowpass filtering of an existing unwrapped phase; this makes possible an iterative algorithm in which the result of each iteration provides the estimate for the next. An example illustrates the results of optimal discontinuity placement and the improvement from unwrapping of the residual phase.

  14. Development of chick embryos in 1 Hz to 100 kHz magnetic fields.

    PubMed

    Juutilainen, J; Saali, K

    1986-01-01

    Chick embryos were exposed during their 48 first hours of development to sinusoidally oscillating magnetic fields. The frequencies 1 Hz, 10 Hz, 16.7 Hz, 30 Hz, 50 Hz, 1 kHz, 10 kHz and 100 kHz, and the field strengths 0.1, 1, 10 and 100 A/m were used. Each exposure group consisted of 20 eggs. After the exposure, the embryos were examined for abnormalities and classified by the developmental stage. The percentage of abnormal embryos (%AE) was significantly increased at frequencies from 16.7 Hz to 100 kHz. Above a threshold field strength of about 0.1 to 1 A/m, %AE was rather independent of the field strength, varying from 16% to 56% in different exposure groups. 13% of the sham-exposed control embryos (n = 150) were abnormal. Only the 0.1 A/m exposure group differed significantly from the controls at 1 Hz, and no significant effect was found at 10 Hz. The developmental stage was in general not affected by the magnetic fields, but some abnormal embryos showed retarded development.

  15. A Triad of Highly Reduced, Linear Iron Nitrosyl Complexes: {FeNO}(8-10).

    PubMed

    Chalkley, Matthew J; Peters, Jonas C

    2016-09-19

    Given the importance of Fe-NO complexes in both human biology and the global nitrogen cycle, there has been interest in understanding their diverse electronic structures. Herein a redox series of isolable iron nitrosyl complexes stabilized by a tris(phosphine)borane (TPB) ligand is described. These structurally characterized iron nitrosyl complexes reside in the following highly reduced Enemark-Feltham numbers: {FeNO}(8) , {FeNO}(9) , and {FeNO}(10) . These {FeNO}(8-10) compounds are each low-spin, and feature linear yet strongly activated nitric oxide ligands. Use of Mössbauer, EPR, NMR, UV/Vis, and IR spectroscopy, in conjunction with DFT calculations, provides insight into the electronic structures of this uncommon redox series of iron nitrosyl complexes. In particular, the data collectively suggest that {TPBFeNO}(8-10) are all remarkably covalent. This covalency is likely responsible for the stability of this system across three highly reduced redox states that correlate with unusually high Enemark-Feltham numbers. PMID:27560776

  16. DISSOLUTION OF PLUTONIUM METAL IN 8-10 M NITRIC ACID

    SciTech Connect

    Rudisill, T.; Pierce, R.

    2012-02-21

    The H-Canyon facility will be used to dissolve Pu metal for subsequent purification and conversion to plutonium dioxide (PuO{sub 2}) using Phase II of HB-Line. To support the new mission, the development of a Pu metal dissolution flowsheet which utilizes concentrated (8-10 M) nitric acid (HNO{sub 3}) solutions containing potassium fluoride (KF) is required. Dissolution of Pu metal in concentrated HNO{sub 3} is desired to eliminate the need to adjust the solution acidity prior to purification by anion exchange. The preferred flowsheet would use 8-10 M HNO{sub 3}, 0.015-0.07 M KF, and 0.5-1.0 g/L Gd to dissolve the Pu up to 6.75 g/L. An alternate flowsheet would use 8-10 M HNO{sub 3}, 0.1-0.2 M KF, and 1-2 g/L B to dissolve the Pu. The targeted average Pu metal dissolution rate is 20 mg/min-cm{sup 2}, which is sufficient to dissolve a 'standard' 2250-g Pu metal button in 24 h. Plutonium metal dissolution rate measurements showed that if Gd is used as the nuclear poison, the optimum dissolution conditions occur in 10 M HNO{sub 3}, 0.04-0.05 M KF, and 0.5-1.0 g/L Gd at 112 to 116 C (boiling). These conditions will result in an estimated Pu metal dissolution rate of {approx}11-15 mg/min-cm{sup 2} and will result in dissolution times of 36-48 h for standard buttons. The recommended minimum and maximum KF concentrations are 0.03 M and 0.07 M, respectively. The maximum KF concentration is dictated by a potential room-temperature Pu-Gd-F precipitation issue at low Pu concentrations. The purpose of the experimental work described in this report was two-fold. Initially a series of screening experiments was performed to measure the dissolution rate of Pu metal as functions of the HNO{sub 3}, KF, and Gd or B concentrations. The objective of the screening tests was to propose optimized conditions for subsequent flowsheet demonstration tests. Based on the rate measurements, this study found that optimal dissolution conditions in solutions containing 0.5-1.0 g/L Gd occurred in 8-10

  17. Technological Discontinuities and Organizational Environments.

    ERIC Educational Resources Information Center

    Tushman, Michael L.; Anderson, Philip

    1986-01-01

    Technological effects on environmental conditions are analyzed using longitudinal data from the minicomputer, cement, and airline industries. Technology evolves through periods of incremental change punctuated by breakthroughs that enhance or destroy the competence of firms. Competence-destroying discontinuities increase environmental turbulence;…

  18. The Morphosyntax of Discontinuous Exponence

    ERIC Educational Resources Information Center

    Campbell, Amy Melissa

    2012-01-01

    This thesis offers a systematic treatment of discontinuous exponence, a pattern of inflection in which a single feature or a set of features bundled in syntax is expressed by multiple, distinct morphemes. This pattern is interesting and theoretically relevant because it represents a deviation from the expected one-to-one relationship between…

  19. Audiogram of the chicken (Gallus gallus domesticus) from 2 Hz to 9 kHz.

    PubMed

    Hill, Evan M; Koay, Gimseong; Heffner, Rickye S; Heffner, Henry E

    2014-10-01

    The pure-tone thresholds of four domestic female chickens were determined from 2 Hz to 9 kHz using the method of conditioned suppression/avoidance. At a level of 60 dB sound pressure level (re 20 μN/m(2)), their hearing range extends from 9.1 Hz to 7.2 kHz, with a best sensitivity of 2.6 dB at 2 kHz. Chickens have better sensitivity than humans for frequencies below 64 Hz; indeed, their sensitivity to infrasound exceeds that of the homing pigeon. However, when threshold testing moved to the lower frequencies, the animals required additional training before their final thresholds were obtained, suggesting that they may perceive frequencies below 64 Hz differently than higher frequencies. PMID:25092127

  20. Desmethyl Macrolides: Synthesis and Evaluation of 4,8,10-Tridesmethyl Cethromycin

    PubMed Central

    2013-01-01

    Antibiotic-resistant bacteria are emerging at an alarming rate in both hospital and community settings. Motivated by this issue, we have prepared desmethyl (i.e., replacing methyl groups with hydrogens) analogues of third-generation macrolide drugs telithromycin (TEL, 2) and cethromycin (CET, 6), both of which are semisynthetic derivatives of flagship macrolide antibiotic erythromycin (1). Herein, we report the total synthesis, molecular modeling, and biological evaluation of 4,8,10-tridesmethyl cethromycin (7). In MIC assays, CET analogue 7 was found to be equipotent with TEL (2) against a wild-type E. coli strain, more potent than previously disclosed desmethyl TEL congeners 3, 4, and 5, but 4-fold less potent than TEL (2) against a mutant E. coli A2058G strain. PMID:24470840

  1. Spatiotemporal path discontinuities of wavepackets propagating across a meta-atom

    PubMed Central

    Yoo, Insang; Han, Chung Kyu; Shin, Dong-Soo; Lee, K. J. B.; Wu, J. W.; Moon, Han Seb; Wright, Oliver B.; Lee, Sam H.

    2014-01-01

    The realization of phase discontinuities across metasurfaces has led to a new class of reflection and refraction. Here we present theory and experiment on the discontinuous propagation of wavepackets across subwavelength-thickness meta-atoms. Using acoustic waves, we observe the process of wavepackets traversing a meta-atom with abrupt displacements, which appear as path discontinuities on a space-time diagram. We construct a tunable meta-atom from two coupled resonators at ~500 Hz, map the spatiotemporal trajectories of individual sonic pulses, and reveal discontinuities at the meta-atom where the pulses exit at a time ~50 ms ahead or behind their arrivals. Applications include thin acoustic metasurface lenses. PMID:24728015

  2. 38 CFR 21.7635 - Discontinuance dates.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....S.C. 3680(e)) (b) Course discontinued—course interrupted—course terminated—course not satisfactorily...) (e) Discontinued by VA. If VA discontinues payment to a reservist following the procedures stated...

  3. Bursts in discontinuous Aeolian saltation

    PubMed Central

    Carneiro, M. V.; Rasmussen, K. R.; Herrmann, H. J.

    2015-01-01

    Close to the onset of Aeolian particle transport through saltation we find in wind tunnel experiments a regime of discontinuous flux characterized by bursts of activity. Scaling laws are observed in the time delay between each burst and in the measurements of the wind fluctuations at the fluid threshold Shields number θc. The time delay between each burst decreases on average with the increase of the Shields number until sand flux becomes continuous. A numerical model for saltation including the wind-entrainment from the turbulent fluctuations can reproduce these observations and gives insight about their origin. We present here also for the first time measurements showing that with feeding it becomes possible to sustain discontinuous flux even below the fluid threshold. PMID:26073305

  4. Discontinuities in recurrent neural networks.

    PubMed

    Gavaldá, R; Siegelmann, H T

    1999-04-01

    This article studies the computational power of various discontinuous real computational models that are based on the classical analog recurrent neural network (ARNN). This ARNN consists of finite number of neurons; each neuron computes a polynomial net function and a sigmoid-like continuous activation function. We introduce arithmetic networks as ARNN augmented with a few simple discontinuous (e.g., threshold or zero test) neurons. We argue that even with weights restricted to polynomial time computable reals, arithmetic networks are able to compute arbitrarily complex recursive functions. We identify many types of neural networks that are at least as powerful as arithmetic nets, some of which are not in fact discontinuous, but they boost other arithmetic operations in the net function (e.g., neurons that can use divisions and polynomial net functions inside sigmoid-like continuous activation functions). These arithmetic networks are equivalent to the Blum-Shub-Smale model, when the latter is restricted to a bounded number of registers. With respect to implementation on digital computers, we show that arithmetic networks with rational weights can be simulated with exponential precision, but even with polynomial-time computable real weights, arithmetic networks are not subject to any fixed precision bounds. This is in contrast with the ARNN that are known to demand precision that is linear in the computation time. When nontrivial periodic functions (e.g., fractional part, sine, tangent) are added to arithmetic networks, the resulting networks are computationally equivalent to a massively parallel machine. Thus, these highly discontinuous networks can solve the presumably intractable class of PSPACE-complete problems in polynomial time.

  5. Reinforced ceramics employing discontinuous phases

    SciTech Connect

    Becher, P.F.

    1990-01-01

    The fracture toughness of ceramics can be improved by the incorporation of a variety of discontinuous reinforcing phases and microstructures. Observations of crack paths in these systems indicate that these reinforcing phases bridge the crack tip wake region. Recent developments in micromechanics toughening models applicable to such systems are discussed and compared with experimental observations. Because material parameters and microstructural characteristics are considered, the crack bridging models provide a means to optimize the toughening effects. 18 refs., 2 figs.

  6. 40 CFR 159.167 - Discontinued studies.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Discontinued studies. 159.167 Section 159.167 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS... Discontinued studies. The fact that a study has been discontinued before the planned termination must...

  7. 40 CFR 159.167 - Discontinued studies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Discontinued studies. 159.167 Section 159.167 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS... Discontinued studies. The fact that a study has been discontinued before the planned termination must...

  8. 40 CFR 159.167 - Discontinued studies.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 24 2014-07-01 2014-07-01 false Discontinued studies. 159.167 Section 159.167 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS... Discontinued studies. The fact that a study has been discontinued before the planned termination must...

  9. 40 CFR 159.167 - Discontinued studies.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Discontinued studies. 159.167 Section 159.167 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS... Discontinued studies. The fact that a study has been discontinued before the planned termination must...

  10. 40 CFR 159.167 - Discontinued studies.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Discontinued studies. 159.167 Section 159.167 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS... Discontinued studies. The fact that a study has been discontinued before the planned termination must...

  11. Discontinuous mixed covolume methods for parabolic problems.

    PubMed

    Zhu, Ailing; Jiang, Ziwen

    2014-01-01

    We present the semidiscrete and the backward Euler fully discrete discontinuous mixed covolume schemes for parabolic problems on triangular meshes. We give the error analysis of the discontinuous mixed covolume schemes and obtain optimal order error estimates in discontinuous H(div) and first-order error estimate in L(2).

  12. Closure Report for Corrective Action Unit 346: Areas 8, 10 Housekeeping Sites, Nevada Test Site, Nevada

    SciTech Connect

    K. B. Campbell

    2003-08-01

    This Closure Report documents the closure activities conducted for Corrective Action Unit (CAU) 346: Areas 8, 10 Housekeeping Sites. CAU 346 is listed in Appendix III of the Federal Facility Agreement and Consent Order (FFACO, 1996) and consists of the following 14 Corrective Action Sites (CASs) located in Areas 8 and 10 of the Nevada Test Site (NTS): (1) CAS 08-22-04: Drums (2); (2) CAS 08-22-11: Drums; Bucket; (3) CAS 08-24-02: Battery; (4) CAS 10-14-01: Transformer; (5) CAS 10-22-06: Drum (Gas Block); (6) CAS 10-22-10: Drum (Gas Block); (7) CAS 10-22-12: Drum (Gas Block); (8) CAS 10-22-13: Drum (Gas Block); (9) CAS 10-22-16: Drum (Gas Block); (10) CAS 10-22-22: Drum; (11) CAS 10-22-25: Drum; (12) CAS 10-22-36: Paint Can; (13) CAS 10-22-37: Gas Block; and (14) CAS 10-24-11: Battery. Closure activities consisted of closing each CAS by removing debris and/or material, disposing of the generated waste, and verifying that each site was clean-closed by visual inspection and/or laboratory analysis of soil verification samples.

  13. Thomson Scattering at 250 kHz

    NASA Astrophysics Data System (ADS)

    Young, William; den Hartog, D. J.; Morton, L. A.; MST Team

    2015-11-01

    The fast Thomson scattering diagnostic on the MST Reversed-Field Pinch experiment now measures electron temperature at rates of up to 250 kHz, allowing for single shot analysis of phenomena that previously required ensembles of measurements from many shots. Recent laser upgrades include the addition of a second Nd:glass amplifier (giving a total of six amplifiers including four Nd:YAG stages) and optimization of neodymium doping levels within the glass amplifier stages to reduce thermal defocusing. The master-oscillator power-amplifier laser system operates in a pulse-burst mode where the laser generates multiple pulses per flashlamp firing and these bursts of laser pulses are repeated multiple times. When optimizing for the largest number of laser pulses, the laser produces up to 30 pulses at a rate of 100 kHz per burst repeated up to 4 times every 2 ms for a total of 120 temperature measurements per MST discharge. When optimizing for fastest pulsing rate, the laser can produce 8 pulses at 250 kHz within a single burst. A laser system upgrade currently underway is replacement of the diode-pumped pulsed Nd:YVO4 master oscillator with a CW laser chopped by an acoustic-optic modulator; this upgrade may enable pulsing rates faster than 250 kHz. This work is supported by the US DOE and NSF.

  14. Discontinuous dynamics with grazing points

    NASA Astrophysics Data System (ADS)

    Akhmet, M. U.; Kıvılcım, A.

    2016-09-01

    Discontinuous dynamical systems with grazing solutions are discussed. The group property, continuation of solutions, continuity and smoothness of solutions are thoroughly analyzed. A variational system around a grazing solution which depends on near solutions is constructed. Orbital stability of grazing cycles is examined by linearization. Small parameter method is extended for analysis of grazing orbits, and bifurcation of cycles is observed in an example. Linearization around an equilibrium grazing point is discussed. The results can be extended on functional differential equations, partial differential equations and others. Appropriate illustrations are depicted to support the theoretical results.

  15. DISSOLUTION OF PLUTONIUM METAL IN 8-10 M NITRIC ACID

    SciTech Connect

    Rudisill, T. S.; Pierce, R. A.

    2012-07-02

    The H-Canyon facility will be used to dissolve Pu metal for subsequent purification and conversion to plutonium dioxide (PuO{sub 2}) using Phase II of HB-Line. To support the new mission, the development of a Pu metal dissolution flowsheet which utilizes concentrated (8-10 M) nitric acid (HNO{sub 3}) solutions containing potassium fluoride (KF) is required. Dissolution of Pu metal in concentrated HNO{sub 3} is desired to eliminate the need to adjust the solution acidity prior to purification by anion exchange. The preferred flowsheet would use 8-10 M HNO{sub 3}, 0.015-0.07 M KF, and 0.5-1.0 g/L Gd to dissolve the Pu up to 6.75 g/L. An alternate flowsheet would use 8-10 M HNO{sub 3}, 0.05-0.2 M KF, and 1-2 g/L B to dissolve the Pu. The targeted average Pu metal dissolution rate is 20 mg/min-cm{sup 2}, which is sufficient to dissolve a “standard” 2250-g Pu metal button in 24 h. Plutonium metal dissolution rate measurements showed that if Gd is used as the nuclear poison, the optimum dissolution conditions occur in 10 M HNO{sub 3}, 0.04-0.05 M KF, and 0.5-1.0 g/L Gd at 112 to 116 °C (boiling). These conditions will result in an estimated Pu metal dissolution rate of ~11-15 mg/min-cm{sup 2} and will result in dissolution times of 36-48 h for standard buttons. The recommended minimum and maximum KF concentrations are 0.03 M and 0.07 M, respectively. The data also indicate that lower KF concentrations would yield dissolution rates for B comparable to those observed with Gd at the same HNO{sub 3} concentration and dissolution temperature. To confirm that the optimal conditions identified by the dissolution rate measurements can be used to dissolve Pu metal up to 6.75 g/L in the presence of representative concentrations of Fe and Gd or B, a series of experiments was performed to demonstrate the flowsheets. In three of the five experiments, the offgas generation rate during the dissolution was measured and samples were analyzed for hydrogen gas (H{sub 2}). The use of

  16. RHIC 10 Hz global orbit feedback system

    SciTech Connect

    Michnoff, R.; Arnold, L.; Carboni, L.; Cerniglia, P; Curcio, A.; DeSanto, L.; Folz, C.; Ho, C.; Hoff, L.; Hulsart, R.; Karl, R.; Luo, Y.; Liu, C.; MacKay, W.; Mahler, G.; Meng, W.; Mernick, K.; Minty, M.; Montag, C.; Olsen, R.; Piacentino, J.; Popken, P.; Przybylinski, R.; Ptitsyn, V.; Ritter, J.; Schoenfeld, R.; Thieberger, P.; Tuozzolo, J.; Weston, A.; White, J.; Ziminski, P.; Zimmerman, P.

    2011-03-28

    Vibrations of the cryogenic triplet magnets at the Relativistic Heavy Ion Collider (RHIC) are suspected to be causing the horizontal beam perturbations observed at frequencies around 10 Hz. Several solutions to counteract the effect have been considered in the past, including a local beam feedback system at each of the two experimental areas, reinforcing the magnet base support assembly, and a mechanical servo feedback system. However, the local feedback system was insufficient because perturbation amplitudes outside the experimental areas were still problematic, and the mechanical solutions are very expensive. A global 10 Hz orbit feedback system consisting of 36 beam position monitors (BPMs) and 12 small dedicated dipole corrector magnets in each of the two 3.8 km circumference counter-rotating rings has been developed and commissioned in February 2011. A description of the system architecture and results with beam will be discussed.

  17. Spectroscopic observations of HZ Herculis. II

    NASA Technical Reports Server (NTRS)

    Bopp, B. W.; Grupsmith, G.; Mcmillan, R. S.; Vanden Bout, P. A.; Wootten, H. A.

    1973-01-01

    Preliminary results from an extensive series of spectroscopic observations of the HZ Her optical counterpart of the eclipsing, pulsating X-ray binary Her X-1. Spectrograms with a dispersion of 30 A/mm reveal a spectral type as late as F5 near minimum in the light curve with the G-band and metallic lines present. Narrow Fe lines show that HZ Her is not a rapid rotator. Low-dispersion (115 A/mm) spectra, obtained with 10-minute time resolution, reveal rapid (10-min) variations in the 4640 N III emission and in the 4471 He I absorbtion features. The H-beta absorption is variable in equivalent width, and shows evidence of being partially filled with emission.

  18. Humans perceive flicker artifacts at 500 Hz

    NASA Astrophysics Data System (ADS)

    Davis, James; Hsieh, Yi-Hsuan; Lee, Hung-Chi

    2015-02-01

    Humans perceive a stable average intensity image without flicker artifacts when a television or monitor updates at a sufficiently fast rate. This rate, known as the critical flicker fusion rate, has been studied for both spatially uniform lights, and spatio-temporal displays. These studies have included both stabilized and unstablized retinal images, and report the maximum observable rate as 50-90 Hz. A separate line of research has reported that fast eye movements known as saccades allow simple modulated LEDs to be observed at very high rates. Here we show that humans perceive visual flicker artifacts at rates over 500 Hz when a display includes high frequency spatial edges. This rate is many times higher than previously reported. As a result, modern display designs which use complex spatio-temporal coding need to update much faster than conventional TVs, which traditionally presented a simple sequence of natural images.

  19. 78 FR 42102 - Termination of Radiotelephone Medium Frequency 2182 kHz Watchkeeping, 2187.5 kHz Digital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-15

    ... SECURITY Coast Guard Termination of Radiotelephone Medium Frequency 2182 kHz Watchkeeping, 2187.5 kHz Digital Selective Calling Channel Guard, and 2670 kHz Broadcasts ACTION: Notice. SUMMARY: The United States Coast Guard is announcing that it will no longer maintain a watch on 2182 kHz, will no...

  20. A Practical Guide to Regression Discontinuity

    ERIC Educational Resources Information Center

    Jacob, Robin; Zhu, Pei; Somers, Marie-Andrée; Bloom, Howard

    2012-01-01

    Regression discontinuity (RD) analysis is a rigorous nonexperimental approach that can be used to estimate program impacts in situations in which candidates are selected for treatment based on whether their value for a numeric rating exceeds a designated threshold or cut-point. Over the last two decades, the regression discontinuity approach has…

  1. 38 CFR 21.7135 - Discontinuance dates.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) Eligibility expires. If the veteran is pursuing a course on the date of expiration of eligibility as... Bill-Active Duty) Payments-Educational Assistance § 21.7135 Discontinuance dates. The effective date of... dependent. If more than one type of reduction or discontinuance is involved, the earliest date will...

  2. 38 CFR 21.7135 - Discontinuance dates.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) Eligibility expires. If the veteran is pursuing a course on the date of expiration of eligibility as... Bill-Active Duty) Payments-Educational Assistance § 21.7135 Discontinuance dates. The effective date of... dependent. If more than one type of reduction or discontinuance is involved, the earliest date will...

  3. Discontinued drugs in 2008: cardiovascular drugs.

    PubMed

    Zhang, Xu-Song; Xiang, Bing-Ren

    2009-07-01

    This perspective is part of an annual series of papers discussing drugs dropped from clinical development in the previous year. Specifically, this paper focuses on the 16 cardiovascular drugs discontinued in 2008. Information for this perspective was derived from a search of the Pharmaprojects database for drugs discontinued after reaching Phase I-III clinical trials. PMID:19548849

  4. Blueprints for the 2003 California History-Social Science Standards Tests for Grades 8, 10, and 11.

    ERIC Educational Resources Information Center

    California State Dept. of Education, Sacramento.

    Beginning in 2003, there will be no standardized or norm-referenced test in history-social science for California students. That test is being replaced by assessments at grades 8, 10, and 11 based on California History-Social Science (H-SS) Content Standards. The H-SS standards tests at grades 10 and 11 count for 20% of the Academic Performance…

  5. BACKGROUND MATERIALS FOR WATERSHED CENTRAL DEVELOPMENT WORKSHOP HELD JANUARY 8-10, 2007, IN ATLANTA, GEORGIA (CD)

    EPA Science Inventory

    A development workshop for Watershed Central was held in Atlanta, Georgia, January 8-10, 2007. Participants in the workshop included representatives of EPA’s Office of Water, Office of Environmental Information, Office of Research and Development, and several Regional Offices. ...

  6. A Taste of China: A Series of Lessons for the Gifted/Talented 8-10 Year Old Student.

    ERIC Educational Resources Information Center

    Mitchell, Bruce M.; And Others

    The document provides three lesson plans designed to introduce gifted children (8-10 years old) to a study of China. The plans are built around three stories which portray specific conditions of the Country; the plans are designed to develop specific understandings related to economic conditions caused by floods and droughts, the potential menaces…

  7. 10 Hz flicker improves recognition memory in older people

    PubMed Central

    Williams, Jonathan; Ramaswamy, Deepa; Oulhaj, Abderrahim

    2006-01-01

    Background 10 Hz electroencephalographic (EEG) alpha rhythms correlate with memory performance. Alpha and memory decline in older people. We wished to test if alpha-like EEG activity contributes to memory formation. Flicker can elicit alpha-like EEG activity. We tested if alpha-frequency flicker enhances memory in older people. Pariticpants aged 67–92 identified short words that followed 1 s of flicker at 9.0 Hz, 9.5 Hz, 10.0 Hz, 10.2 Hz, 10.5 Hz, 11.0 Hz, 11.5 Hz or 500 Hz. A few minutes later, we tested participants' recognition of the words (without flicker). Results Flicker frequencies close to 10 Hz (9.5–11.0 Hz) facilitated the identification of the test words in older participants. The same flicker frequencies increased recognition of the words more than other frequencies (9.0 Hz, 11.5 Hz and 500 Hz), irrespective of age. Conclusion The frequency-specificity of flicker's effects in our participants paralleled the power spectrum of EEG alpha in the general population. This indicates that alpha-like EEG activity may subserve memory processes. Flicker may be able to help memory problems in older people. PMID:16515710

  8. Medical factors associated with early IVF discontinuation.

    PubMed

    Troude, Pénélope; Guibert, Juliette; Bouyer, Jean; de La Rochebrochard, Elise

    2014-03-01

    Even when IVF is reimbursed by the social insurance system, as in France, high discontinuation rates have been reported and some patients drop out as soon as the first failed IVF cycle. This study aims to investigate medical factors associated with treatment discontinuation in an IVF centre after the first unsuccessful cycle. The study included 5135 couples recruited in eight French IVF centres and who had had an unsuccessful first IVF cycle in these centres in 2000-2002 (i.e. no live birth). Of these couples with a first failed IVF, 1337 did not have a second IVF in the centre (26%, 'early discontinuation group') and 3798 continued treatment with a second IVF in the centre. The characteristics of couples who discontinued IVF treatment were compared with those who continued using logistic regressions. Older women, women with duration of infertility >5years, with female factor or unexplained infertility, with 0 or 1 oocyte retrieved and no embryo transfer during the first IVF were more likely to discontinue treatment early. Risk of early discontinuation was associated with medical factors that are also well known to be associated with impaired chance of successful IVF. Even when IVF is reimbursed by the social insurance system, as in France, high discontinuation rates have been reported and some patients drop out as soon as the first failed IVF cycle. This study aims to investigate medical factors associated with treatment discontinuation in an IVF centre after the first unsuccessful cycle. The study included 5135 couples recruited in eight French IVF centres who had had an unsuccessful first IVF cycle in these centres in 2000-2002 (i.e. who remained childless after a first cycle). Of these couples with a first failed IVF, 1337 did not have a second IVF in the centre and 3798 continued treatment with a second IVF in the centre. The characteristics of couples who discontinued IVF treatment were compared with those who continued. After a first failed IVF cycle, more

  9. Adsorption of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) on a soil organic matter. A DFT M05 computational study.

    PubMed

    Sviatenko, Liudmyla K; Gorb, Leonid; Shukla, Manoj K; Seiter, Jennifer M; Leszczynska, Danuta; Leszczynski, Jerzy

    2016-04-01

    Adsorption of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) by soil organic matter considering the Leonardite Humic Acid (LHA) model at the M05/tzvp level of Density Functional Theory (DFT) applying cluster approximation has been investigated. Different orientations of CL-20 toward LHA surface were examined. It was found that deprotonation of LHA is required to obtain stable complexes with CL-20. Hydrogen bonds between CL-20 and deprotonated LHA were analyzed applying the atoms in molecules (AIM) theory. An attachment or removal of an electron with respect to the complex does not have significant effect on mutual orientation of the adsorbent in complexes. It was shown that adsorbed CL-20 does not undergo redox transformation and, therefore, adsorption on soil organic matter may be responsible for decrease of the degradation rate of CL-20 in soil.

  10. Adsorption of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) on a soil organic matter. A DFT M05 computational study.

    PubMed

    Sviatenko, Liudmyla K; Gorb, Leonid; Shukla, Manoj K; Seiter, Jennifer M; Leszczynska, Danuta; Leszczynski, Jerzy

    2016-04-01

    Adsorption of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) by soil organic matter considering the Leonardite Humic Acid (LHA) model at the M05/tzvp level of Density Functional Theory (DFT) applying cluster approximation has been investigated. Different orientations of CL-20 toward LHA surface were examined. It was found that deprotonation of LHA is required to obtain stable complexes with CL-20. Hydrogen bonds between CL-20 and deprotonated LHA were analyzed applying the atoms in molecules (AIM) theory. An attachment or removal of an electron with respect to the complex does not have significant effect on mutual orientation of the adsorbent in complexes. It was shown that adsorbed CL-20 does not undergo redox transformation and, therefore, adsorption on soil organic matter may be responsible for decrease of the degradation rate of CL-20 in soil. PMID:26814703

  11. Ambient noise measurements from 100 Hz to 80 kHz in an Alaskan fjord.

    PubMed

    McConnell, S O; Schilt, M P; Dworski, J G

    1992-04-01

    Measurements covering a broad frequency range from 100 Hz to 80 kHz have been made in Behm Canal, Alaska. This site represents a fairly deep embayment (400 m) with a soft bottom (porosity of about 0.8) and, hence, the noise detected at the hydrophones is affected negligibly by multipath contributions except possibly at the lowest frequencies. Data were gathered over a wide range of wind speeds (0 to 15 m/s) and during periods of rain and snow. Several unique and noteworthy results were obtained. Foremost was the observation that the wind-generated noise level measured during the winter was approximately 5 dB lower than during the summer for the same wind speeds and air-sea temperature differences (air temperature about the same as or colder than the sea surface). The summer data agree well with the most recent published measurements and are approximately 2 dB higher than the standard Knudsen/Wenz reference spectra. It appeared that below-freezing air temperatures and snow were responsible for the 5 dB offset between the summer and winter data. Most reported wind noise measurements are restricted to frequencies less than 20 kHz. Those that go beyond this frequency display a noticeable hump above the usual--17 dB/decade power-law slope, and the Behm Canal measurements show that this hump continues to 80 kHz where the spectrum rejoins the extension of the canonical power-law slope.

  12. [Prospective evaluation of antidepressant discontinuation].

    PubMed

    Mourad, I; Lejoyeux, M; Adès, J

    1998-01-01

    The authors prospectively assessed symptoms induced by the interruption of antidepressants in 16 patients (11 women and 5 men), aged from 33 to 85 years (mean = 52.4 +/- 16.4), treated with antidepressants since at least two weeks. All patients were free of alcohol abuse or dependence disorder and of other dependence to psychoactive substances. None of them presented medical illness. Diagnosis were made by separate evaluations by two authors and confirmed with a semistructered assessment instrument: the Schedule for Affective Disorders and Schizophrenia (Lifetime Version). All patients were submitted to a brutal discontinuation of their antidepressant agent. Patients were assessed twice, before the interruption of the antidepressant, and 72 hours later. Effects of antidepressant interruption were assessed by several means. Modification of anxiety and depression were evaluated using the Montgomery Asberg Depression Rating Scale (MADRS) and the Hamilton Anxiety Scale. Symptoms of withdrawal were assessed with Cassano and al.'s scale SESSH including an evaluation of anxiety, agitation, irritability, anergy, difficulty on concentrating, depersonalization, sleep and appetite disorders, muscle pains, nausea, tremor, sweating, altered taste, hyperosmia, paresthesias, photophobia, motor incoordination, dizziness, hyperacousia pain, delirium. Fourteen of the 16 patients (87.5%) presented modifications of their somatic or psychic state 3 days after the interruption of the antidepressant treatment. Most frequent symptoms were: increase in anxiety (31%), increase in irritability (25%), sleep disorders (19%), decrease of anergia and fatigue (19%). Mean scores of anxiety and depression were not significantly modified by the withdrawal. Following TCAs interruption (7 patients) most frequent symptoms were sleep disorders; increase in anxiety, nausea. Among patients withdrawn from SSRIs (6 patients), most frequent symptoms were increase in anxiety, increase in irritability

  13. Solving ordinary differential equations with discontinuities

    SciTech Connect

    Gear, C.W.; Osterby, O.

    1981-09-01

    An algorithm is described that can detect and locate some discontinuities and provide information about their size, order and position. However, the success of the algorithm is strongly dependent on the location of the discontinuity with respect to the steps that straddle it. The major advantage of the scheme appears to be that a more reliable error estimate can be used when a discontinuity is present so that codes will be more robust. In some cases significant savings may accrue but it appears that a better restarting procedure than the one used will be necessary to realize most of those benefits.

  14. 47 CFR 80.882 - 2182 kHz watch.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false 2182 kHz watch. 80.882 Section 80.882 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE... kHz watch. Ships subject to this subpart must maintain a watch on the frequency 2182 kHz pursuant...

  15. 47 CFR 80.882 - 2182 kHz watch.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false 2182 kHz watch. 80.882 Section 80.882 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE... kHz watch. Ships subject to this subpart must maintain a watch on the frequency 2182 kHz pursuant...

  16. 47 CFR 80.882 - 2182 kHz watch.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false 2182 kHz watch. 80.882 Section 80.882 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE... kHz watch. Ships subject to this subpart must maintain a watch on the frequency 2182 kHz pursuant...

  17. 47 CFR 80.882 - 2182 kHz watch.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false 2182 kHz watch. 80.882 Section 80.882 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE... kHz watch. Ships subject to this subpart must maintain a watch on the frequency 2182 kHz pursuant...

  18. 47 CFR 80.882 - 2182 kHz watch.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false 2182 kHz watch. 80.882 Section 80.882 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE... kHz watch. Ships subject to this subpart must maintain a watch on the frequency 2182 kHz pursuant...

  19. Thomson scattering at 250 kHz

    NASA Astrophysics Data System (ADS)

    Young, W. C.; Den Hartog, D. J.

    2015-12-01

    Several upgrades have been applied to the high-repetition-rate Thomson scattering diagnostic on the MST experiment, having increased the rate and number of electron temperature measurements. The detector portion of the Thomson scattering system requires 1.5-2.0 J, 10-20 ns laser pulses at 1064 nm. A high-repetition-rate laser produces suitable pulses for short 3-4 pulse bursts with only 3 μs pulse spacing. Alternatively, the laser timing can be optimized to maximize the number of pulses in a single burst, producing up to 44 pulses at a rate of 100 kHz. The laser follows a master oscillator, power amplifier architecture. Upgrades to the laser include: a new acousto-optic modulator chopped CW laser based master oscillator, a sixth power amplifier, optimized Nd doping within Nd:glass amplifiers via optical modeling of the pump chamber, and a yet to be installed new cavity reflector. Additionally, a new long wavelength filter has been added to the Thomson scattering diagnostic's polychromator based detector, allowing possible detection of net electron drift.

  20. Discontinuous spirals of stable periodic oscillations.

    PubMed

    Sack, Achim; Freire, Joana G; Lindberg, Erik; Pöschel, Thorsten; Gallas, Jason A C

    2013-01-01

    We report the experimental discovery of a remarkable organization of the set of self-generated periodic oscillations in the parameter space of a nonlinear electronic circuit. When control parameters are suitably tuned, the wave pattern complexity of the periodic oscillations is found to increase orderly without bound. Such complex patterns emerge forming self-similar discontinuous phases that combine in an artful way to produce large discontinuous spirals of stability. This unanticipated discrete accumulation of stability phases was detected experimentally and numerically in a Duffing-like proxy specially designed to bypass noisy spectra conspicuously present in driven oscillators. Discontinuous spirals organize the dynamics over extended parameter intervals around a focal point. They are useful to optimize locking into desired oscillatory modes and to control complex systems. The organization of oscillations into discontinuous spirals is expected to be generic for a class of nonlinear oscillators. PMID:24284508

  1. Discontinuous Spirals of Stable Periodic Oscillations

    PubMed Central

    Sack, Achim; Freire, Joana G.; Lindberg, Erik; Pöschel, Thorsten; Gallas, Jason A. C.

    2013-01-01

    We report the experimental discovery of a remarkable organization of the set of self-generated periodic oscillations in the parameter space of a nonlinear electronic circuit. When control parameters are suitably tuned, the wave pattern complexity of the periodic oscillations is found to increase orderly without bound. Such complex patterns emerge forming self-similar discontinuous phases that combine in an artful way to produce large discontinuous spirals of stability. This unanticipated discrete accumulation of stability phases was detected experimentally and numerically in a Duffing-like proxy specially designed to bypass noisy spectra conspicuously present in driven oscillators. Discontinuous spirals organize the dynamics over extended parameter intervals around a focal point. They are useful to optimize locking into desired oscillatory modes and to control complex systems. The organization of oscillations into discontinuous spirals is expected to be generic for a class of nonlinear oscillators. PMID:24284508

  2. Discontinuity stresses in metallic pressure vessels

    NASA Technical Reports Server (NTRS)

    1971-01-01

    The state of the art, criteria, and recommended practices for the theoretical and experimental analyses of discontinuity stresses and their distribution in metallic pressure vessels for space vehicles are outlined. The applicable types of pressure vessels include propellant tanks ranging from main load-carrying integral tank structure to small auxiliary tanks, storage tanks, solid propellant motor cases, high pressure gas bottles, and pressurized cabins. The major sources of discontinuity stresses are discussed, including deviations in geometry, material properties, loads, and temperature. The advantages, limitations, and disadvantages of various theoretical and experimental discontinuity analysis methods are summarized. Guides are presented for evaluating discontinuity stresses so that pressure vessel performance will not fall below acceptable levels.

  3. Discontinuous structure transition in a Debye cluster

    SciTech Connect

    Sheridan, T. E.

    2012-05-15

    We consider the structural phases of a cluster of identical particles confined in a two-dimensional biharmonic well and interacting through a screened Coulomb (Yukawa) potential (e.g., dusty plasma). For n = 6 particles, we show that there are one discontinuous and three continuous structure transitions, giving five structure phases. Two of these phases, the straight line and zigzag configurations, have previously been studied experimentally. We experimentally verify the discontinuous transition and observe the remaining three phases.

  4. Origins of the 520-km discontinuity

    NASA Astrophysics Data System (ADS)

    Vinnik, Lev

    2016-04-01

    The 520-km discontinuity is often explained by the phase transition from wadsleyite to ringwoodite, although the theoretical impedance of this transition is so small that the related converted and reflected seismic phases could hardly be seen in the seismograms. At the same time there are numerous reports on observations of a large discontinuity at this depth, especially in the data on SS precursors and P-wave wide-angle reflections. Revenaugh and Jordan (1991) argued that this discontinuity is related to the garnet/post-garnet transformation. Gu et al. (1998) preferred very deep continental roots extending into the transition zone. Deuss and Woodhouse proposed splitting of the 520-km discontinuity into two discontinuities, whilst Bock (1994) denied evidence of the 520-km discontinuity in the SS precursors. Our approach to this problem is based on the analysis of S and P receiver functions. Most of our data are related to hot-spots in and around the Atlantic where the appropriate converted phases are often comparable in amplitude with P410s and S410p. Both S and P receiver functions provide strong evidence of a low S velocity in a depth range from 450 km to 510 km at some locations. The 520-km discontinuity appears to be the base of this low-velocity layer. Our observations of the low S velocity in the upper transition zone are very consistent with the indications of a drop in the solidus temperature of carbonated peridotite in the same pressure range (Keshav et al. 2011), and this phenomenon provides a viable alternative to the other explanations of the 520-km discontinuity.

  5. Discontinuities of multi-Regge amplitudes

    NASA Astrophysics Data System (ADS)

    Fadin, V. S.

    2015-04-01

    In the BFKL approach, discontinuities of multiple production amplitudes in invariant masses of produced particles are discussed. It turns out that they are in evident contradiction with the BDS ansatz for n-gluon amplitudes in the planar N = 4 SYM at n ≥ 6. An explicit expression for the NLO discontinuity of the two-to-four amplitude in the invariant mass of two produced gluons is is presented.

  6. Variations of Hales Discontinuity beneath South India

    NASA Astrophysics Data System (ADS)

    Goyal, Ayush; Kosre, Goukaran Kumar; Borah, Kajaljyoti

    2016-04-01

    Thermodynamic studies show the spinel-garnet transition in fertile and hot mantle should be relatively narrow and should show up in the seismological studies as a discontinuity. The evidence for a shallow lithospheric mantle discontinuity was first proposed by Hales (1969) based on seismological travel time measurement from the Early Rise experiment in the Central United States, where a ~4% increase in the S-wave velocity at a depth of 75 km was observed. The recent studies show, in cratonic blocks with colder geotherms, that it appears at greater depths and over broader intervals, that is, from the Moho to 150 km depth. Different studies interpreted that Hales discontinuity may be due to seismic anisotropy or pervasive partial melts or cation ordering in mantle olivine. In the present study an attempt is made to model the Hales discontinuity in the South Indian shield, by jointly inverting group velocity dispersion and receiver functions, calculated from teleseismic earthquakes recorded at 20 broadband seismograph locations in the study region. South Indian shield is an amalgamation of several crustal blocks, namely, Eastern Dharwar Craton (EDC), Western Dharwar Craton (WDC), Southern Granulite Terrain (SGT) etc. Inversion modeling results show deeper Hales discontinuity (~104-110 km depth) in the south of WDC and SGT, while in the north of Western Dharwar Craton and Eastern Dharwar Craton it varies from ~70-80 km. It is also observed that the Hales Discontinuity is present at greater depth in the western part of Dharwar Craton, compared to the eastern part. Details of the depth, thickness, and the cause of the Hales discontinuity are also investigated. Keywords: Hales Discontinuity, South Indian Shield, Receiver Function, Craton, Inversion modeling.

  7. Validity and interunit reliability of 10 Hz and 15 Hz GPS units for assessing athlete movement demands.

    PubMed

    Johnston, Richard J; Watsford, Mark L; Kelly, Stephen J; Pine, Matthew J; Spurrs, Robert W

    2014-06-01

    The purpose of this study was to assess the validity and interunit reliability of 10 Hz (Catapult) and 15 Hz (GPSports) Global Positioning System (GPS) units and investigate the differences between these units as measures of team sport athlete movement demands. A team sport simulation circuit was completed by 8 trained male participants. The movement demands examined included: total distance covered (TD), average peak speed, and the distance covered, time spent, and the number of efforts performed low-speed running (0.00-13.99 km · h(-1)), high-speed running (14.00-19.99 km · h(-1)), and very high-speed running (>20.00 km · h(-1)). The degree of difference between the 10 Hz and the 15 Hz GPS units and validity was assessed using a paired samples t-test. Pearson's correlations were also used for validity assessment. Interunit reliability was established using percentage typical error of measurement (%TEM) and intraclass correlations. The findings revealed that 10 Hz GPS units were a valid (p > 0.05) and reliable (%TEM = 1.3%) measure of TD. In contrast, the 15 Hz GPS units exhibited lower validity for TD and average peak speed. Further, as the speed of movement increased the level of error for the 10 Hz and 15 Hz GPS units increased (%TEM = 0.8-19.9). The findings from this study suggest that comparisons should not be undertaken between 10 Hz and 15 Hz GPS units. In general, the 10 Hz GPS units measured movement demands with greater validity and interunit reliability than the 15 Hz units, however, both 10 Hz and 15 Hz units provided the improved measures of movement demands in comparison to 1 Hz and 5 Hz GPS units.

  8. The crystal structure and morphology of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) p-xylene solvate: a joint experimental and simulation study.

    PubMed

    Shen, Fanfan; Lv, Penghao; Sun, Chenghui; Zhang, Rubo; Pang, Siping

    2014-01-01

    The crystal structure of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaiso-wurtzitane (CL-20) p-xylene solvate, and the solvent effects on the crystal faces of CL-20 were studied through a combined experimental and theoretical method. The properties were analyzed by thermogravimetry-differential scanning calorimetry (TG-DSC), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD).The growth morphology of CL-20p-xylene solvate crystal was predicted with a modified attachment energy model. The crystal structure of CL-20p-xylene solvate belonged to the Pbca space group with the unit cell parameters, a=8.0704(12) Å, b=13.4095(20) Å, c=33.0817(49) Å, and Z=4, which indicated that the p-xylene solvent molecules could enter the crystal lattice of CL-20 and thus the CL-20 p-xylene solvate is formed. According to the solvent-effected attachment energy calculations, (002) and (11-1) faces should not be visible at all, while the percentage area of the (011) face could be increased from 7.81% in vacuum to 12.51% in p-xylene solution. The predicted results from the modified attachment energy model agreed very well with the observed morphology of crystals grown from p-xylene solution. PMID:25401400

  9. 27 CFR 555.128 - Discontinuance of business.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Discontinuance of business... Discontinuance of business. Where an explosive materials business or operations is discontinued and succeeded by... such facts and shall be delivered to the successor. Where discontinuance of the business or...

  10. 27 CFR 478.127 - Discontinuance of business.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Discontinuance of business... Records § 478.127 Discontinuance of business. Where a licensed business is discontinued and succeeded by a... be delivered to the successor. Where discontinuance of the business is absolute, the records shall...

  11. 27 CFR 478.57 - Discontinuance of business.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Discontinuance of business... Licenses § 478.57 Discontinuance of business. (a) Where a firearm or ammunition business is either discontinued or succeeded by a new owner, the owner of the business discontinued or succeeded shall within...

  12. 27 CFR 478.127 - Discontinuance of business.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2014-04-01 2014-04-01 false Discontinuance of business... Records § 478.127 Discontinuance of business. Where a licensed business is discontinued and succeeded by a... be delivered to the successor. Where discontinuance of the business is absolute, the records shall...

  13. 27 CFR 478.57 - Discontinuance of business.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2014-04-01 2014-04-01 false Discontinuance of business... Licenses § 478.57 Discontinuance of business. (a) Where a firearm or ammunition business is either discontinued or succeeded by a new owner, the owner of the business discontinued or succeeded shall within...

  14. 27 CFR 478.127 - Discontinuance of business.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2013-04-01 2013-04-01 false Discontinuance of business... Records § 478.127 Discontinuance of business. Where a licensed business is discontinued and succeeded by a... be delivered to the successor. Where discontinuance of the business is absolute, the records shall...

  15. 27 CFR 555.128 - Discontinuance of business.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2014-04-01 2014-04-01 false Discontinuance of business... Discontinuance of business. Where an explosive materials business or operations is discontinued and succeeded by... such facts and shall be delivered to the successor. Where discontinuance of the business or...

  16. 27 CFR 555.128 - Discontinuance of business.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2013-04-01 2013-04-01 false Discontinuance of business... Discontinuance of business. Where an explosive materials business or operations is discontinued and succeeded by... such facts and shall be delivered to the successor. Where discontinuance of the business or...

  17. 27 CFR 17.187 - Discontinuance of business.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Discontinuance of business... PRODUCTS Miscellaneous Provisions § 17.187 Discontinuance of business. The manufacturer shall notify TTB when business is to be discontinued. Upon discontinuance of business, a manufacturer's entire stock...

  18. 27 CFR 478.57 - Discontinuance of business.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Licenses § 478.57 Discontinuance of business. (a) Where a firearm or ammunition business is either discontinued or succeeded by a new owner, the owner of the business discontinued or succeeded shall within 30... 27 Alcohol, Tobacco Products and Firearms 3 2013-04-01 2013-04-01 false Discontinuance of...

  19. Method for simulating discontinuous physical systems

    DOEpatents

    Baty, Roy S.; Vaughn, Mark R.

    2001-01-01

    The mathematical foundations of conventional numerical simulation of physical systems provide no consistent description of the behavior of such systems when subjected to discontinuous physical influences. As a result, the numerical simulation of such problems requires ad hoc encoding of specific experimental results in order to address the behavior of such discontinuous physical systems. In the present invention, these foundations are replaced by a new combination of generalized function theory and nonstandard analysis. The result is a class of new approaches to the numerical simulation of physical systems which allows the accurate and well-behaved simulation of discontinuous and other difficult physical systems, as well as simpler physical systems. Applications of this new class of numerical simulation techniques to process control, robotics, and apparatus design are outlined.

  20. Rockburst Generation in Discontinuous Rock Masses

    NASA Astrophysics Data System (ADS)

    He, Ben-Guo; Zelig, Ravit; Hatzor, Yossef H.; Feng, Xia-Ting

    2016-10-01

    We study rockburst generation in discontinuous rock masses using theoretical and numerical approaches. We begin by developing an analytical solution for the energy change due to tunneling in a continuous rock mass using linear elasticity. We show that the affected zone where most of the increase in elastic strain energy takes place is restricted to an annulus that extends to a distance of three diameters from the tunnel center, regardless of initial tunnel diameter, magnitude of in situ stress, and in situ stress ratio. By considering local elastic strain concentrations, we further delineate the Rockbursting Prone Zone found to be concentrated in an annulus that extends to one diameter from the tunnel center, regardless of original stress ratio, magnitude, and the stiffness of the rock mass. We proceed by arguing that in initially discontinuous rock masses shear stress amplification due to tunneling will inevitably trigger block displacements along preexisting discontinuities much before shear failure of intact rock elements will ensue, because of the lower shear strength of discontinuities with respect to intact rock elements, provided of course that the blocks are removable. We employ the numerical discrete element DDA method to obtain, quantitatively, the kinetic energy, the elastic strain energy, and the dissipated energy in the affected zone in a discontinuous rock due to tunneling. We show that the kinetic energy of ejected blocks due to strain relaxation increases with increasing initial stress and with decreasing frictional resistance of preexisting discontinuities. Finally, we demonstrate how controlled strain energy release by means of top heading and bench excavation methodology can assist in mitigating rockburst hazards due to stain relaxation.

  1. Ray theory of gas dynamic discontinuities

    NASA Astrophysics Data System (ADS)

    Kentzer, Czeslaw P.

    1987-12-01

    A geometric theory of the motion of surfaces of discontinuity is based on the quasi-linear algebraic system of generalized Rankine-Hugoniot jump conditions for an ideal gas. Vanishing of a characteristic determinant is necessary for the existence of a nontrivial jump. Geometrical, dynamical, and persistence conditions are applied to the discontinuity of an arbitrary strength, resulting in a set of Hamiltonian equations for the position coordinates and for the space-time normal to the surface. The rays are defined as the integral curves of the Hamiltonian system and generate the singular surface that satisfies the imposed jump conditions.

  2. Cathodic protection of pipelines in discontinuous permafrost

    SciTech Connect

    Mitchell, C.J.; Wright, M.D.; Waslen, D.W.

    1997-08-01

    This paper discusses the challenges in providing cathodic protection for a pipeline located in an area with discontinuous permafrost. Specific challenges included: unknown time for the permafrost to melt out, unpredictable current distribution characteristics and wet, inaccessible terrain. Based on preliminary pipe-to-soil data, it appears that cathodic protection coverage was achieved in discontinuous permafrost regions without the need of local anodes. Future work is required to verify whether this conclusion can be extended over the course of an annual freeze-thaw cycle.

  3. Current discontinuities on superconducting cosmic strings

    SciTech Connect

    Troyan, E. Vlasov, Yu. V.

    2011-07-15

    The propagation of current perturbations on superconducting cosmic strings is considered. The conditions for the existence of discontinuities similar to shock waves have been found. The formulas relating the string parameters and the discontinuity propagation speed are derived. The current growth law in a shock wave is deduced. The propagation speeds of shock waves with arbitrary amplitudes are calculated. The reason why there are no shock waves in the case of time-like currents (in the 'electric' regime) is explained; this is attributable to the shock wave instability with respect to perturbations of the string world sheet.

  4. Global climate change and international security. Report on a conference held at Argonne National Laboratory, May 8--10, 1991

    SciTech Connect

    Rice, M.

    1991-12-31

    On May 8--10, 1991, the Midwest Consortium of International Security Studies (MCISS) and Argonne National Laboratory cosponsored a conference on Global Climate Change and International Security. The aim was to bring together natural and social scientists to examine the economic, sociopolitical, and security implications of the climate changes predicted by the general circulation models developed by natural scientists. Five themes emerged from the papers and discussions: (1) general circulation models and predicted climate change; (2) the effects of climate change on agriculture, especially in the Third World; (3) economic implications of policies to reduce greenhouse gas emissions; (4) the sociopolitical consequences of climate change; and (5) the effect of climate change on global security.

  5. Prognostic Significance of Neuroendocrine Differentiation in Patients With Gleason Score 8-10 Prostate Cancer Treated With Primary Radiotherapy

    SciTech Connect

    Krauss, Daniel J.; Hayek, Sylvia; Amin, Mitual; Ye Hong; Kestin, Larry L.; Zadora, Steven; Vicini, Frank A.; Cotant, Matthew; Brabbins, Donald S.; Ghilezan, Michel I.; Gustafson, Gary S.; Martinez, Alvaro A.

    2011-11-01

    Purpose: To determine the prognostic significance of neuroendocrine differentiation (NED) in Gleason score 8-10 prostate cancer treated with primary radiotherapy (RT). Methods and Materials: Chromogranin A (CgA) staining was performed and overseen by a single pathologist on core biopsies from 176 patients from the William Beaumont prostate cancer database. A total of 143 had evaluable biopsy material. Staining was quantified as 0%, <1%, 1-10%, or >10% of tumor cells. Patients received external beam RT alone or together with high-dose-rate brachytherapy. Cox regression and Kaplan-Meier estimates determined if the presence/frequency of neuroendocrine cells correlated with clinical endpoints. Results: Median follow-up was 5.5 years. Forty patients (28%) had at least focal positive CgA staining (<1% n = 21, 1-10% n = 11, >10% n = 8). No significant differences existed between patients with or without staining in terms of age, pretreatment prostate-specific antigen, tumor stage, hormone therapy administration, % biopsy core involvement, mean Gleason score, or RT dose/modality. CgA staining concentration independently predicted for biochemical and clinical failure, distant metastases (DM), and cause-specific survival (CSS). For patients with <1% vs. >1% staining, 10-year DM rates were 13.4% vs. 55.3%, respectively (p = 0.001), and CSS was 91.7% vs. 58.9% (p < 0.001). As a continuous variable, increasing CgA staining concentration predicted for inferior rates of DM, CSS, biochemical control, and any clinical failure. No differences in outcomes were appreciated for patients with 0% vs. <1% NED. Conclusions: For Gleason score 8-10 prostate cancer, >1% NED is associated with inferior clinical outcomes for patients treated with radiotherapy. This relates most directly to an increase in distant disease failure.

  6. Stability of Conservation Laws with Discontinuous Coefficients

    NASA Astrophysics Data System (ADS)

    Klausen, Runhild Aae; Risebro, Nils Henrik

    1999-09-01

    We prove L1 contractivity of weak solutions to a conservation law with a flux function that may depend discontinuously on the space variable. Furthermore, we show that the L1 difference between solutions to conservation laws with different flux functions is bounded by the total variation with respect to the space variable, of the difference between the flux functions.

  7. Cathodic protection of pipelines in discontinuous permafrost

    SciTech Connect

    Mitchell, C.J.; Wright, M.D.; Waslen, D.W.

    1997-10-01

    There are many unknowns and challenges in providing cathodic protection (CP) for a pipeline located in discontinuous permafrost areas. Preliminary pipe-to-soil data indicates that CP coverage was achieved in these regions without needing local anodes. Work is required to verify whether this conclusion can be extended over the course of an annual freeze-thaw cycle.

  8. Characterization of Asymmetric Coplanar Waveguide Discontinuities

    NASA Technical Reports Server (NTRS)

    Dib, Nihad I.; Katehi, Linda P. B.; Gupta, Minoo; Ponchak, George E.

    1993-01-01

    A general technique to characterize asymmetric coplanar waveguide (CPW) discontinuities with air bridges where both the fundamental coplanar and slotline modes may be excited together is presented. First, the CPW discontinuity without air bridges is analyzed using the space-domain integral equation (SDIE) approach. Second, the parameters (phase, amplitude, and wavelength) of the coplanar and slotline modes are extracted from an amplitude modulated-like standing wave existing in the CPW feeding lines. Then a 2n x 2n generalized scattering matrix of the n-port discontinuity without air bridges is derived which includes the occurring mode conversion. Finally, this generalized scattering matrix is reduced to an n x n matrix by enforcing suitable conditions at the ports which correspond to the excited slotline mode. For the purpose of illustration, the method is applied to a shielded asymmetric short-end CPW shunt stub, the scattering parameters of which are compared with those of a symmetric one. Experiments are performed on both discontinuities and the results are in good agreement with theoretical data. The advantages of using air bridges in CPW circuits as opposed to bond wires are also discussed.

  9. 27 CFR 18.38 - Permanent discontinuance.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Permanent discontinuance. 18.38 Section 18.38 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS PRODUCTION OF VOLATILE FRUIT-FLAVOR CONCENTRATE Qualification...

  10. 27 CFR 18.38 - Permanent discontinuance.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Permanent discontinuance. 18.38 Section 18.38 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS PRODUCTION OF VOLATILE FRUIT-FLAVOR CONCENTRATE Qualification...

  11. 77 FR 33314 - POSTNET Barcode Discontinuation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-06

    ... Postal Service published a final rule in the Federal Register (77 FR 26185-26191) to discontinue price... Periodicals automation letters and flats) that were inadvertently omitted in the original final rule, but does... and allow only Intelligent Mail barcodes (IMbs) for automation price eligibility purposes,...

  12. Unstructured discontinuous Galerkin for seismic inversion.

    SciTech Connect

    van Bloemen Waanders, Bart Gustaaf; Ober, Curtis Curry; Collis, Samuel Scott

    2010-04-01

    This abstract explores the potential advantages of discontinuous Galerkin (DG) methods for the time-domain inversion of media parameters within the earth's interior. In particular, DG methods enable local polynomial refinement to better capture localized geological features within an area of interest while also allowing the use of unstructured meshes that can accurately capture discontinuous material interfaces. This abstract describes our initial findings when using DG methods combined with Runge-Kutta time integration and adjoint-based optimization algorithms for full-waveform inversion. Our initial results suggest that DG methods allow great flexibility in matching the media characteristics (faults, ocean bottom and salt structures) while also providing higher fidelity representations in target regions. Time-domain inversion using discontinuous Galerkin on unstructured meshes and with local polynomial refinement is shown to better capture localized geological features and accurately capture discontinuous-material interfaces. These approaches provide the ability to surgically refine representations in order to improve predicted models for specific geological features. Our future work will entail automated extensions to directly incorporate local refinement and adaptive unstructured meshes within the inversion process.

  13. Nonrenewable resource extraction under discontinuous price policy

    SciTech Connect

    Kalt, J.P.; Otten, A.L.

    1985-01-01

    Temporal discontinuities in public policy with respect to nonrenewable resource pricing can have significant impacts on the time patterns of resource extraction. These impacts arise from the effect of price discontinuities on the relative values of Hotelling rents across time periods. Whether faced with intertemporal price continuity or price discontinuity, the planning task of the wealth-maximizing producer is to equate the present value of each period's marginal contribution to the stream of net revenues from production across time. This rule for extraction provides the key to understanding the response to a price jump such as occurs upon the removal of price controls. The rational producer holds back at least some output until the price jump occurs. At the moment, the producer pushes output up sharply, raising marginal extraction cost by the absolute amount of the price jump and, thereby, maintaining the value of the Hotelling rent given by the gap between price and marginal extraction cost. US natural gas policy options, as well as plausible alternatives, are simulated to illustrate the effects of discontinuous regulatory regimes. 15 references, 1 table.

  14. Discontinued drugs in 2010: cardiovascular drugs.

    PubMed

    Zhao, Hong-ping; Zhang, Xu-song; Xiang, Bing-ren

    2011-10-01

    This perspective is a paper discussing drugs dropped from clinical development in the previous years. Specifically, this paper focuses on 16 cardiovascular drugs discontinued in 2010 after reaching Phase I - III clinical trials. Information for this perspective is mainly derived from a search of Pharmaprojects. PMID:21870899

  15. 40 CFR 721.10025 - 10H-Phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... C8-10-branched alkyl) derivs. 721.10025 Section 721.10025 Protection of Environment ENVIRONMENTAL...-branched alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified as 10H-phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  16. 40 CFR 721.10025 - 10H-Phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... C8-10-branched alkyl) derivs. 721.10025 Section 721.10025 Protection of Environment ENVIRONMENTAL...-branched alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified as 10H-phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  17. 40 CFR 721.10022 - Benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... C8-10-branched alkyl) derivs. 721.10022 Section 721.10022 Protection of Environment ENVIRONMENTAL...-branched alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  18. 40 CFR 721.10022 - Benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... C8-10-branched alkyl) derivs. 721.10022 Section 721.10022 Protection of Environment ENVIRONMENTAL...-branched alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  19. 40 CFR 721.10025 - 10H-Phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... C8-10-branched alkyl) derivs. 721.10025 Section 721.10025 Protection of Environment ENVIRONMENTAL...-branched alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified as 10H-phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  20. 40 CFR 721.10025 - 10H-Phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... C8-10-branched alkyl) derivs. 721.10025 Section 721.10025 Protection of Environment ENVIRONMENTAL...-branched alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified as 10H-phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  1. 40 CFR 721.10022 - Benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... C8-10-branched alkyl) derivs. 721.10022 Section 721.10022 Protection of Environment ENVIRONMENTAL...-branched alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  2. 40 CFR 721.10022 - Benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... C8-10-branched alkyl) derivs. 721.10022 Section 721.10022 Protection of Environment ENVIRONMENTAL...-branched alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  3. 40 CFR 721.10023 - Benzenamine, N-phenyl-, ar ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...-rich C8-10-branched alkyl) derivs. 721.10023 Section 721.10023 Protection of Environment ENVIRONMENTAL...-10-branched alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as benzenamine, N-phenyl-, ar,ar′-(C9-rich C8-10-branched...

  4. 40 CFR 721.10023 - Benzenamine, N-phenyl-, ar ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...-rich C8-10-branched alkyl) derivs. 721.10023 Section 721.10023 Protection of Environment ENVIRONMENTAL...-10-branched alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as benzenamine, N-phenyl-, ar,ar′-(C9-rich C8-10-branched...

  5. 40 CFR 721.10023 - Benzenamine, N-phenyl-, ar ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...-rich C8-10-branched alkyl) derivs. 721.10023 Section 721.10023 Protection of Environment ENVIRONMENTAL...-10-branched alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as benzenamine, N-phenyl-, ar,ar′-(C9-rich C8-10-branched...

  6. 40 CFR 721.10025 - 10H-Phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... C8-10-branched alkyl) derivs. 721.10025 Section 721.10025 Protection of Environment ENVIRONMENTAL...-branched alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified as 10H-phenothiazine, ar, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  7. 40 CFR 721.10022 - Benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... C8-10-branched alkyl) derivs. 721.10022 Section 721.10022 Protection of Environment ENVIRONMENTAL...-branched alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as benzenamine, N-phenyl-, ar′-(C9-rich C8-10-branched alkyl) derivs (PMN...

  8. In-process discontinuity detection during friction stir welding

    NASA Astrophysics Data System (ADS)

    Shrivastava, Amber

    The objective of this work is to develop a method for detecting the creation of discontinuities (e.g., voids) during friction stir welding. Friction stir welding is inherently cost-effective, however, the need for significant weld inspection can make the process cost-prohibitive. A new approach to weld inspection is required -- where an in-situ characterization of weld quality can be obtained, reducing the need for post-process inspection. Friction stir welds with discontinuity and without discontinuity were created. In this work, discontinuities are generated by reducing the friction stir tool rotation frequency and increasing the tool traverse speed in order to create "colder" welds. During the welds, forces are measured. Discontinuity sizes for welds are measured by computerized tomography. The relationship between the force transients and the discontinuity sizes indicate that the force measurement during friction stir welding can be effectively used for detecting discontinuities in friction stir welds. The normalized force transient data and normalized discontinuity size are correlated to develop a criterion for discontinuity detection. Additional welds are performed to validate the discontinuity detection method. The discontinuity sizes estimated by the force measurement based method are in good agreement with the discontinuity sizes measured by computerized tomography. These results show that the force measurement based discontinuity detection model method can be effectively used to detect discontinuities during friction stir welding.

  9. 60 HZ beam motion reduction at NSLS UV storage ring

    SciTech Connect

    Singh, O.V.

    1997-01-01

    A significant reduction in 60 hz beam motion has been achieved in the UV storage ring. From the wide band harmonic beam motion signal, 60 hz signal is extracted by tuned bandpass filter. This signal is processed by the phase and amplitude adjustment circuits and then, it is fed into the harmonic orbit generation circuits. Several harmonics, near the tune, were canceled by employing one circuit for each harmonic. The design and description of this experiment is given in this paper. The results showing reduction in beam motion at 60 hz are also provided.

  10. An adaptive pseudospectral method for discontinuous problems

    NASA Technical Reports Server (NTRS)

    Augenbaum, Jeffrey M.

    1988-01-01

    The accuracy of adaptively chosen, mapped polynomial approximations is studied for functions with steep gradients or discontinuities. It is shown that, for steep gradient functions, one can obtain spectral accuracy in the original coordinate system by using polynomial approximations in a transformed coordinate system with substantially fewer collocation points than are necessary using polynomial expansion directly in the original, physical, coordinate system. It is also shown that one can avoid the usual Gibbs oscillation associated with steep gradient solutions of hyperbolic pde's by approximation in suitably chosen coordinate systems. Continuous, high gradient solutions are computed with spectral accuracy (as measured in the physical coordinate system). Discontinuous solutions associated with nonlinear hyperbolic equations can be accurately computed by using an artificial viscosity chosen to smooth out the solution in the mapped, computational domain. Thus, shocks can be effectively resolved on a scale that is subgrid to the resolution available with collocation only in the physical domain. Examples with Fourier and Chebyshev collocation are given.

  11. Discontinuous percolation transitions in real physical systems

    NASA Astrophysics Data System (ADS)

    Cho, Y. S.; Kahng, B.

    2011-11-01

    We study discontinuous percolation transitions (PTs) in the diffusion-limited cluster aggregation model of the sol-gel transition as an example of real physical systems, in which the number of aggregation events is regarded as the number of bonds occupied in the system. When particles are Brownian, in which cluster velocity depends on cluster size as vs˜sη with η=-0.5, a larger cluster has less probability to collide with other clusters because of its smaller mobility. Thus, the cluster is effectively more suppressed in growth of its size. Then the giant cluster size increases drastically by merging those suppressed clusters near the percolation threshold, exhibiting a discontinuous PT. We also study the tricritical behavior by controlling the parameter η, and the tricritical point is determined by introducing an asymmetric Smoluchowski equation.

  12. Discontinuous envelope function in semiconductor heterostructures

    NASA Astrophysics Data System (ADS)

    Drouhin, Henri-Jean; Bottegoni, Federico; Nguyen, T. L. Hoai; Wegrowe, Jean-Eric; Fishman, Guy

    2013-09-01

    Based on a proper definition of the current operators for non-quadratic Hamiltonians, we derive the expression for the transport current which involves the derivative of the imaginary part of the free-electron current, highlighting peculiarities of the extra terms. The expression of the probability current, when Spin-Orbit Interaction (SOI) is taken into account, requires a reformulation of the boudary conditions. This is especially important for tunnel heterojunctions made of non-centrosymmetric semiconductors. Therefore, we consider a model case: tunneling of conduction electrons through a [110]-oriented GaAs barrier. The new boundary conditions are reduced to two set of equations: the first one expresses the discontinuity of the envelope function at the interface while the other one expresses the discontinuity of the derivative of the envelope function.

  13. Bounded extremum seeking with discontinuous dithers

    DOE PAGES

    Scheinker, Alexander; Scheinker, David

    2016-03-21

    The analysis of discontinuous extremum seeking (ES) controllers, e.g. those applicable to digital systems, has historically been more complicated than that of continuous controllers. We establish a simple and general extension of a recently developed bounded form of ES to a general class of oscillatory functions, including functions discontinuous with respect to time, such as triangle or square waves with dead time. We establish our main results by combining a novel idea for oscillatory control with an extension of functional analytic techniques originally utilized by Kurzweil, Jarnik, Sussmann, and Liu in the late 80s and early 90s and recently studiedmore » by Durr et al. Lastly, we demonstrate the value of the result with an application to inverter switching control.« less

  14. Constant-force approach to discontinuous potentials.

    PubMed

    Orea, Pedro; Odriozola, Gerardo

    2013-06-01

    Aiming to approach the thermodynamical properties of hard-core systems by standard molecular dynamics simulation, we propose setting a repulsive constant-force for overlapping particles. That is, the discontinuity of the pair potential is replaced by a linear function with a large negative slope. Hence, the core-core repulsion, usually modeled with a power function of distance, yields a large force as soon as the cores slightly overlap. This leads to a quasi-hardcore behavior. The idea is tested for a triangle potential of short range. The results obtained by replica exchange molecular dynamics for several repulsive forces are contrasted with the ones obtained for the discontinuous potential and by means of replica exchange Monte Carlo. We found remarkable agreements for the vapor-liquid coexistence densities as well as for the surface tension.

  15. Accelerated Transonic Flow past a curvature discontinuity

    NASA Astrophysics Data System (ADS)

    de Cointet, Thomas; Ruban, Anatoly

    2014-11-01

    The aim of this talk is to investigate High Reynolds number Transonic flow past a discontinuity in body curvature. Starting with the inviscid flow outside the boundary layer, our analysis will focus on the flow in a vicinity of the point of discontinuity, where a solution of the Euler equations will be sought in self-similar form. This reduces the Euler equations to an ordinary differential equation. The analysis of this equation shows that the pressure gradient on the airfoil surface develops a strong singularity, which is proportional to (x0 - x) - 1 / 3 as the discontinuity point x0 is approached. We then study the response of the boundary layer to this extremely favourable pressure gradient. We show that the boundary layer splits into two parts, the main body of the boundary layer that becomes inviscid on approach to the singularity, and a thin viscous sublayer situated near the wall. The analysis of the behaviour of the solution in the viscous sublayer shows that Prandtl's hierarchical concept breaks down in a small region surrounding the singular point, where the viscous-inviscid interaction model should be used. In the final part of this talk we present a full formulation of the viscous-inviscid interaction problem and discuss numerical results.

  16. 14 CFR 221.300 - Discontinuation of electronic tariff system.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Discontinuation of electronic tariff system... of electronic tariff system. In the event that the electronic tariff system is discontinued, or the source of the data is changed, or a filer discontinues its business, all electronic data records prior...

  17. 14 CFR 221.300 - Discontinuation of electronic tariff system.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Discontinuation of electronic tariff system... of electronic tariff system. In the event that the electronic tariff system is discontinued, or the source of the data is changed, or a filer discontinues its business, all electronic data records prior...

  18. 27 CFR 46.138 - Discontinuance of business.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2012-04-01 2011-04-01 true Discontinuance of business. 46.138 Section 46.138 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU....138 Discontinuance of business. A dealer who for any reason discontinues business is not entitled to...

  19. 27 CFR 46.138 - Discontinuance of business.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false Discontinuance of business. 46.138 Section 46.138 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU....138 Discontinuance of business. A dealer who for any reason discontinues business is not entitled to...

  20. 27 CFR 31.162 - Discontinuance of business.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Discontinuance of business... and Reports § 31.162 Discontinuance of business. When a wholesale dealer in liquors who is required, under § 31.160, to file a monthly summary report discontinues business, a monthly summary report...

  1. Program Discontinuance: A Faculty Perspective Revisited. Adopted Fall 2012

    ERIC Educational Resources Information Center

    Academic Senate for California Community Colleges, 2012

    2012-01-01

    The 1998 Academic Senate for California Community Colleges paper Program Discontinuance: A Faculty Perspective presented issues of program discontinuance and addressed principles and key factors for effective faculty participation in the development of fair and equitable program discontinuance processes. In 2009, an Academic Senate resolution…

  2. 39 CFR 241.3 - Discontinuance of post offices.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Discontinuance of post offices. 241.3 Section 241... CLASSIFICATION, AND DISCONTINUANCE § 241.3 Discontinuance of post offices. (a) Introduction—(1) Coverage. This section establishes the rules governing the Postal Service's consideration of whether an existing...

  3. 27 CFR 555.61 - Discontinuance of business or operations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Permits § 555.61 Discontinuance of business or operations. Where an explosive materials business or operations is either discontinued or succeeded by a new owner, the owner of the business or operations... 27 Alcohol, Tobacco Products and Firearms 3 2013-04-01 2013-04-01 false Discontinuance of...

  4. 27 CFR 555.61 - Discontinuance of business or operations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Permits § 555.61 Discontinuance of business or operations. Where an explosive materials business or operations is either discontinued or succeeded by a new owner, the owner of the business or operations... 27 Alcohol, Tobacco Products and Firearms 3 2014-04-01 2014-04-01 false Discontinuance of...

  5. High Power SiGe X-Band (8-10 GHz) Heterojunction Bipolar Transistors and Amplifiers

    NASA Technical Reports Server (NTRS)

    Ma, Zhenqiang; Jiang, Ningyue; Ponchak, George E.; Alterovitz, Samuel A.

    2005-01-01

    Limited by increased parasitics and thermal effects as the device size becomes large, current commercial SiGe power HBTs are difficult to operate at X-band (8-12 GHz) with adequate power added efficiencies at high power levels. We found that, by changing the heterostructure and doping profile of SiGe HBTs, their power gain can be significantly improved without resorting to substantial lateral scaling. Furthermore, employing a common-base configuration with proper doping profile instead of a common-emitter configuration improves the power gain characteristics of SiGe HBTs, which thus permits these devices to be efficiently operated at X-band. In this paper, we report the results of SiGe power HBTs and MMIC power amplifiers operating at 8-10 GHz. At 10 GHz, 22.5 dBm (178 mW) RF output power with concurrent gain of 7.32 dB is measured at the peak power-added efficiency of 20.0% and the maximum RF output power of 24.0 dBm (250 mW) is achieved from a 20 emitter finger SiGe power HBT. Demonstration of single-stage X-band medium-power linear MMIC power amplifier is also realized at 8 GHz. Employing a 10-emitter finger SiGe HBT and on-chip input and output matching passive components, a linear gain of 9.7 dB, a maximum output power of 23.4 dBm and peak power added efficiency of 16% is achieved from the power amplifier. The MMIC exhibits very low distortion with third order intermodulation (IM) suppression C/I of -13 dBc at output power of 21.2 dBm and over 20dBm third order output intercept point (OIP3).

  6. Repeated amphetamine administration and long-term effects on 50-kHz ultrasonic vocalizations: possible relevance to the motivational and dopamine-stimulating properties of the drug.

    PubMed

    Simola, Nicola; Morelli, Micaela

    2015-03-01

    Ultrasonic vocalizations (USVs) of 50kHz are thought to indicate positive affective states in rats, and are increasingly being used to investigate the motivational properties of drugs of abuse. However, previous studies have observed that only dopaminergic psychostimulants of abuse, but not other addictive drugs, stimulate 50-kHz USVs immediately after their administration. This would suggest that 50-kHz USVs induced by addictive dopaminergic psychostimulants might reflect rewarding dopaminergic effect, rather than motivational effect. To elucidate this issue, our study compared the effects of the psychostimulant of abuse amphetamine and the dopamine receptor agonist apomorphine on 50-kHz USVs. Rats that received five drug administrations on alternate days in a novel test-cage were first re-exposed to the test-cage 7 days after treatment discontinuation to assess drug-conditioning, and then received a drug challenge. USVs were recorded throughout the experiments together with locomotor activity. To further clarify how amphetamine and apomorphine influenced 50-kHz USVs, rats were subdivided into "low" and "high" vocalizers, and time-dependence of drug effects was assessed. Amphetamine and apomorphine stimulated both 50-kHz USVs and locomotor activity, though they elicited dissimilar changes in these behaviors, depending on drug dose, rats׳ individual predisposition to vocalize, and time. Moreover, only amphetamine-treated rats displayed both sensitized 50-kHz USVs emission and conditioned vocalizations on test-cage re-exposure. These results indicate that the effects of amphetamine on 50-kHz USVs are not mimicked by a dopaminergic agonist with a low abuse potential, and may further support the usefulness of 50-kHz USVs in the study of the motivational properties of psychoactive drugs.

  7. Repeated amphetamine administration and long-term effects on 50-kHz ultrasonic vocalizations: possible relevance to the motivational and dopamine-stimulating properties of the drug.

    PubMed

    Simola, Nicola; Morelli, Micaela

    2015-03-01

    Ultrasonic vocalizations (USVs) of 50kHz are thought to indicate positive affective states in rats, and are increasingly being used to investigate the motivational properties of drugs of abuse. However, previous studies have observed that only dopaminergic psychostimulants of abuse, but not other addictive drugs, stimulate 50-kHz USVs immediately after their administration. This would suggest that 50-kHz USVs induced by addictive dopaminergic psychostimulants might reflect rewarding dopaminergic effect, rather than motivational effect. To elucidate this issue, our study compared the effects of the psychostimulant of abuse amphetamine and the dopamine receptor agonist apomorphine on 50-kHz USVs. Rats that received five drug administrations on alternate days in a novel test-cage were first re-exposed to the test-cage 7 days after treatment discontinuation to assess drug-conditioning, and then received a drug challenge. USVs were recorded throughout the experiments together with locomotor activity. To further clarify how amphetamine and apomorphine influenced 50-kHz USVs, rats were subdivided into "low" and "high" vocalizers, and time-dependence of drug effects was assessed. Amphetamine and apomorphine stimulated both 50-kHz USVs and locomotor activity, though they elicited dissimilar changes in these behaviors, depending on drug dose, rats׳ individual predisposition to vocalize, and time. Moreover, only amphetamine-treated rats displayed both sensitized 50-kHz USVs emission and conditioned vocalizations on test-cage re-exposure. These results indicate that the effects of amphetamine on 50-kHz USVs are not mimicked by a dopaminergic agonist with a low abuse potential, and may further support the usefulness of 50-kHz USVs in the study of the motivational properties of psychoactive drugs. PMID:25638025

  8. 40 CFR 180.1126 - Codlure, (E,E)-8,10-Dodecadien-1-ol; exemption from the requirement of a tolerance.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL... the insect pheromone codlure, (E,E)-8,10-dodecadien-1-ol, on all raw agricultural commodities...

  9. 40 CFR 180.1126 - Codlure, (E,E)-8,10-Dodecadien-1-ol; exemption from the requirement of a tolerance.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL... the insect pheromone codlure, (E,E)-8,10-dodecadien-1-ol, on all raw agricultural commodities...

  10. 40 CFR 180.1126 - Codlure, (E,E)-8,10-Dodecadien-1-ol; exemption from the requirement of a tolerance.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL... the insect pheromone codlure, (E,E)-8,10-dodecadien-1-ol, on all raw agricultural commodities...

  11. 40 CFR 180.1126 - Codlure, (E,E)-8,10-Dodecadien-1-ol; exemption from the requirement of a tolerance.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL... the insect pheromone codlure, (E,E)-8,10-dodecadien-1-ol, on all raw agricultural commodities...

  12. Visualization, Extraction and Quantification of Discontinuities in Compressible Flows

    NASA Technical Reports Server (NTRS)

    Samtaney, Ravi; Morris, R. D.; Cheeseman, P.; Sunelyansky, V.; Maluf, D.; Wolf, D.

    2000-01-01

    Scientific visualizations of two-dimensional compressible flow of a gas with discontinuities are presented. The numerical analogue to experimental techniques such as schlieren imaging, shadowgraphs, and interferograms are discussed. Edge detection techniques are utilized to identify the discontinuities. In particular, the zero crossing of the Laplacian of a field (usually density) is recommended for extracting the discontinuities. An algorithm to extract and quantify the discontinuities is presented. To illustrate the methods developed in the report, the example chosen is that of an unsteady interaction of a shock wave with a contact discontinuity.

  13. Depressed mantle discontinuities beneath Iceland: Evidence of a garnet controlled 660 km discontinuity?

    NASA Astrophysics Data System (ADS)

    Jenkins, J.; Cottaar, S.; White, R. S.; Deuss, A.

    2016-01-01

    The presence of a mantle plume beneath Iceland has long been hypothesised to explain its high volumes of crustal volcanism. Practical constraints in seismic tomography mean that thin, slow velocity anomalies representative of a mantle plume signature are difficult to image. However it is possible to infer the presence of temperature anomalies at depth from the effect they have on phase transitions in surrounding mantle material. Phase changes in the olivine component of mantle rocks are thought to be responsible for global mantle seismic discontinuities at 410 and 660 km depth, though exact depths are dependent on surrounding temperature conditions. This study uses P to S seismic wave conversions at mantle discontinuities to investigate variation in topography allowing inference of temperature anomalies within the transition zone. We employ a large data set from a wide range of seismic stations across the North Atlantic region and a dense network in Iceland, including over 100 stations run by the University of Cambridge. Data are used to create over 6000 receiver functions. These are converted from time to depth including 3D corrections for variations in crustal thickness and upper mantle velocity heterogeneities, and then stacked based on common conversion points. We find that both the 410 and 660 km discontinuities are depressed under Iceland compared to normal depths in the surrounding region. The depression of 30 km observed on the 410 km discontinuity could be artificially deepened by un-modelled slow anomalies in the correcting velocity model. Adding a slow velocity conduit of -1.44% reduces the depression to 18 km; in this scenario both the velocity reduction and discontinuity topography reflect a temperature anomaly of 210 K. We find that much larger velocity reductions would be required to remove all depression on the 660 km discontinuity, and therefore correlated discontinuity depressions appear to be a robust feature of the data. While it is not possible

  14. Upper mantle discontinuity structure from underside reflections

    NASA Astrophysics Data System (ADS)

    Schmerr, Nicholas C.

    This research investigates Earth structure in the mantle transition zone, a range of depths bounded by two major solid-state phase transformations of the mineral olivine: the conversion of olivine to wadsleyite near 410 km depth, and the dissociation of ringwoodite into Mg-silicate perovskite plus magnesiowuestite near 660 km depth. The phase transformations are dependent upon the thermal and chemical state of the mantle; lateral heterogeneity in mantle temperature and composition will change the transformation depth. The denser, more compact structures of olivine possess higher seismic wave speeds and densities, thus giving rise to seismic discontinuities at the phase transitions. The depth and sharpness of the 410 and 660 km discontinuities are mapped using seismic energy that reflects from the underside of these boundaries to investigate the thermal and chemical state of the mantle. Underside reflections of shear and compressional seismic waves arrive as precursory energy several hundred seconds before the seismic phases SS and PP, which form as underside reflections off the crust. Using broadband datasets of precursors to SS and PP, topographic variation maps of the 410 km and 660 km boundaries are produced for study regions beneath the Pacific Ocean and South American continent. Beneath most of the Pacific, the discontinuities are found close to the global average, suggesting that the mantle in this region is not significantly perturbed in temperature and chemistry. However, within 1000 km of several Pacific hotspots, including Hawaii, there is evidence for hot upwelling material rising through the transition zone that correlates with the edges of extremely hot (i.e., seismically low velocity) regions of the lowermost mantle, supporting whole mantle convection. Beneath the South American continent there is evidence for both thermal and chemical variation near the subducting Nazca plate, consistent with cold, and hydrated materials sinking into the mantle

  15. General spline filters for discontinuous Galerkin solutions

    PubMed Central

    Peters, Jörg

    2015-01-01

    The discontinuous Galerkin (dG) method outputs a sequence of polynomial pieces. Post-processing the sequence by Smoothness-Increasing Accuracy-Conserving (SIAC) convolution not only increases the smoothness of the sequence but can also improve its accuracy and yield superconvergence. SIAC convolution is considered optimal if the SIAC kernels, in the form of a linear combination of B-splines of degree d, reproduce polynomials of degree 2d. This paper derives simple formulas for computing the optimal SIAC spline coefficients for the general case including non-uniform knots. PMID:26594090

  16. Discontinuous Galerkin methods for extended hydrodynamics

    NASA Astrophysics Data System (ADS)

    Suzuki, Yoshifumi

    This dissertation presents a step towards high-order methods for continuum-transition flows. In order to achieve maximum accuracy and efficiency for numerical methods on a distorted mesh, it is desirable that both governing equations and corresponding numerical methods are in some sense compact. We argue our preference for a physical model described solely by first-order partial differential equations called hyperbolic-relaxation equations, and, among various numerical methods, for the discontinuous Galerkin method. Hyperbolic-relaxation equations can be generated as moments of the Boltzmann equation and can describe continuum-transition flows. Two challenging properties of hyperbolic-relaxation equations are the presence of a stiff source term, which drives the system towards equilibrium, and the accompanying change of eigenstructure. The first issue can be solved by an implicit treatment of the source term. To cope with the second difficulty, we develop a space-time discontinuous Galerkin method, based on Huynh's "upwind moment scheme." It is called the DG(1)--Hancock method. The DG(1)--Hancock method for one- and two-dimensional meshes is described, and Fourier analyses for both linear advection and linear hyperbolic-relaxation equations are conducted. The analyses show that the DG(1)--Hancock method is not only accurate but efficient in terms of turnaround time in comparison to other semi- and fully discrete finite-volume and discontinuous Galerkin methods. Numerical tests confirm the analyses, and also show the properties are preserved for nonlinear equations; the efficiency is superior by an order of magnitude. Subsequently, discontinuous Galerkin and finite-volume spatial discretizations are applied to more practical equations, in particular, to the set of 10-moment equations, which are gas dynamics equations that include a full pressure/temperature tensor among the flow variables. Results for flow around a micro-airfoil are compared to experimental data and

  17. Coherent 40-Hz Oscillation Characterizes Dream State in Humans

    NASA Astrophysics Data System (ADS)

    Llinas, Rodolfo; Ribary, Urs

    1993-03-01

    Magnetic recording from five normal human adults demonstrates large 40-Hz coherent magnetic activity in the awake and in rapid-eye-movement (REM) sleep states that is very reduced during delta sleep (deep sleep characterized by delta waves in the electroencephalogram). This 40-Hz magnetic oscillation has been shown to be reset by sensory stimuli in the awake state. Such resetting is not observed during REM or delta sleep. The 40 Hz in REM sleep is characterized, as is that in the awake state, by a fronto-occiptal phase shift over the head. This phase shift has a maximum duration of thickapprox12-13 msec. Because 40-Hz oscillation is seen in wakefulness and in dreaming, we propose it to be a correlate of cognition, probably resultant from coherent 40-Hz resonance between thalamocortical-specific and nonspecific loops. Moreover, we proposed that the specific loops give the content of cognition, and a nonspecific loop gives the temporal binding required for the unity of cognitive experience.

  18. On the 300km discontinuity with Conversion Phases SdP in the Tonga-Fiji Region

    NASA Astrophysics Data System (ADS)

    Zhou, Y.; Sui, Y.

    2011-12-01

    Conversion phases SdP are powerful for retrieving information of velocity interfaces of deep structure of Earth's interior. The high sensitivity seismograph network Japan (Hi-net) has about 800 seismometers which can provide digital waveform data from since 2004 through internet. The difference between the focal depths and the depth of 300 km discontinuity determines the sizes of Fresnel zones at the discontinuity for the waveform data from the seismic network, so seismic waveform of six earthquakes with depths from 145 to 220km between 2004 and 2011 beneath Tonga-Fiji region are retrieved from Hi-net (www.hinet.bosai.go.jp). The magnitudes of the events used are Mb 5.0-5.7 which means there are good signal-noise ratios and relatively simple source time functions. In this study, the focal depths determined with pP phases are provided by EHB database for those before 2006 and www.globalcmt.org for those after that year. After filtering with 0.2-1.0Hz (e.g. Castle and Creager, JGR, 2000) and manually selection, waveform data are divided to 5-8 groups related to the regional locations of seismometers and proceeded with N-th root slant-stack method, then we can get the related vespegram in differential time vs slowness. There are 38 vespegrams for 6 events. From the vespegrams, the conversion phases are picked according to the references of the theoretical values of the differential times and slownesses. The parameters read from vespegrams are inverted with IASP91 model to the depths and locations of conversion points. The conversion points related to 300 km discontinuity are distributed from 302 to 328km in the Fuji-Tonga region. For the vespegrams from one certain event but sub-networks, the depth variation are less than 20 km, mostly are less than 11km. Especially, the depth variation of the event 6 are just 8 km. So in the square region with 200 * 300 km, the lateral variation of the depth of the 300 km discontinuity is relatively small. Comparing with the former

  19. NASA Rat Acoustic Tolerance Test 1994-1995: 8 kHz, 16 kHz, 32 kHz Experiments

    NASA Technical Reports Server (NTRS)

    Mele, Gary D.; Holley, Daniel C.; Naidu, Sujata

    1996-01-01

    Adult male Sprague-Dawley rats were exposed to chronic applied sound (74 to 79 dB, SPL) with octave band center frequencies of either 8, 16 or 32 kHz for up to 60 days. Control cages had ambient sound levels of about 62 dB (SPL). Groups of rats (test vs. control; N=9 per group) were euthanized after 0. 5. 14, 30, and 60 days. On each euthanasia day, objective evaluation of their physiology and behavior was performed using a Stress Assessment Battery (SAB) of measures. In addition, rat hearing was assessed using the brain stem auditory evoked potential (BAER) method after 60 days of exposure. No statistically significant differences in mean daily food use could be attributed to the presence of the applied test sound. Test rats used 5% more water than control rats. In the 8 kHz and 32 kHz tests this amount was statistically significant(P less than .05). This is a minor difference of questionable physiological significance. However, it may be an indication of a small reaction to the constant applied sound. Across all test frequencies, day 5 test rats had 6% larger spleens than control rats. No other body or organ weight differences were found to be statistically significant with respect to the application of sound. This spleen effect may be a transient adaptive process related to adaptation to the constant applied noise. No significant test effect on differential white blood cell counts could be demonstrated. One group demonstrated a low eosinophil count (16 kHz experiment, day 14 test group). However this was highly suspect. Across all test frequencies studied, day 5 test rats had 17% fewer total leukocytes than day 5 control rats. Sound exposed test rats exhibited 44% lower plasma corticosterone concentrations than did control rats. Note that the plasma corticosterone concentration was lower in the sound exposed test animals than the control animals in every instance (frequency exposure and number of days exposed).

  20. Comparable roles of CD44v8-10 and CD44s in the development of bone metastases in a mouse model

    PubMed Central

    Hiraga, Toru; Nakamura, Hiroaki

    2016-01-01

    Cluster of differentiation (CD)44 has been implicated in cancer metastasis to bone. Clinical and experimental studies have suggested that the standard isoform of CD44 (CD44s) and the variant isoform of CD44 (CD44v) enhance metastasis. The present study examined the differential roles of CD44s and CD44v, particularly CD44v8-10, in the development of bone metastases. For this purpose, MDA-MB-231 human breast cancer cells and A549 human lung cancer cells were stably transduced with epithelial splicing regulatory protein 1 (ESRP1), which regulates the alternative splicing of several genes, including CD44. The introduction of ESRP1 induced a splicing switch from CD44s to CD44v, particularly to CD44v8-10, while the total amount of CD44 was rarely affected. However, ESRP1 did not significantly affect cell proliferation, migration, invasion or tumor sphere formation in vitro. Furthermore, ESRP1 did not cause significant differences in the development of bone metastases in a mouse model. As an alternative approach, cancer cells transduced with the CD44v8-10 gene were also established. The overexpression of CD44v8-10 in MCF-7 human breast cancer cells, which rarely express any isoform of CD44, promoted cell migration and sphere formation, whereas the overexpression of CD44v8-10 in MDA-MB-231 cells, which endogenously express high levels of CD44s, did not exert these effects. The results of the present study collectively suggest that the ability of CD44v8-10 to promote tumor aggressiveness and bone metastases is similar to that of CD44s. CD44v8-10 and CD44s may represent potential therapeutic targets for the treatment of bone metastases.

  1. Formation of magnetic discontinuities through viscous relaxation

    SciTech Connect

    Kumar, Sanjay; Bhattacharyya, R.; Smolarkiewicz, P. K.

    2014-05-15

    According to Parker's magnetostatic theorem, tangential discontinuities in magnetic field, or current sheets (CSs), are generally unavoidable in an equilibrium magnetofluid with infinite electrical conductivity and complex magnetic topology. These CSs are due to a failure of a magnetic field in achieving force-balance everywhere and preserving its topology while remaining in a spatially continuous state. A recent work [Kumar, Bhattacharyya, and Smolarkiewicz, Phys. Plasmas 20, 112903 (2013)] demonstrated this CS formation utilizing numerical simulations in terms of the vector magnetic field. The magnetohydrodynamic simulations presented here complement the above work by demonstrating CS formation by employing a novel approach of describing the magnetofluid evolution in terms of magnetic flux surfaces instead of the vector magnetic field. The magnetic flux surfaces being the possible sites on which CSs develop, this approach provides a direct visualization of the CS formation, helpful in understanding the governing dynamics. The simulations confirm development of tangential discontinuities through a favorable contortion of magnetic flux surfaces, as the magnetofluid undergoes a topology-preserving viscous relaxation from an initial non-equilibrium state with twisted magnetic field. A crucial finding of this work is in its demonstration of CS formation at spatial locations away from the magnetic nulls.

  2. Scaling behaviors at discontinuous quantum transitions

    NASA Astrophysics Data System (ADS)

    Nespolo, Jacopo; Campostrini, Massimo; Pelissetto, Andrea; Vicari, Ettore

    First-order (or discontinuous) quantum phase transitions (FOQTs) are characterized by a vanishing energy gap and jumps in the values of some observables across the critical point in the thermodynamic limit. Unlike what happens at continuous transitions, the correlation lengths remain finite at FOQTs. Nevertheless, finite systems at FOQTs exhibit finite-size effects, in the form of a rounding and smoothing of the discontinuities. We show that a scaling theory, similar to the usual finite-size scaling, can be formulated at FOQTs, and that the relevant scaling variable is extremely sensitive to the choice of boundary conditions. We further consider the scaling effects due to the presence of spatial inhomogeneities, in analogy with trap-size scaling at continuous transitions. Our results are supported by numerical simulations on the ferromagnetic quantum Ising chain and on the q-state quantum Potts chain with q > 4 . We provide FSS predictions for the energy gap and the magnetization of finite quantum chains, which can be relevant for quantum computation applications.

  3. Shock and Discontinuities Analysis Tool (SDAT)

    NASA Astrophysics Data System (ADS)

    Viñas, A. F.; Holland, M. P.

    2005-05-01

    We have developed an analysis/visualization tool to study shocks and other discontinuities from satellite observations of plasma and magnetic field data. The tool uses an extension of the Viñas-Scudder analysis method based on the Rankine-Hugoniot conservation equations and published in JGR (1985). SDAT provides shock parameters such as the normal components n, shock speed Us, angle between the normal and the upstream magnetic field ΘBn, Alfvén and magnetosonic Mach numbers, deHoffman-Teller velocity and many other important shock parameters to describe the shock . SDAT was developed fully in IDL. As currently configured, SDAT reads ASCII data from any space mission for the analysis. All data displays and graphics generated by SDAT are written in Postcript and a summary of the analysis is generated as an ASCII file. The input plasma (ρ, V, Tp and Te) and magnetic field (B) data is read from different files at their own native resolution. The tool allows for data zooming in time and the input data can be in any coordinate system. Examples of real satellite data are included to facilitate the learning process in the usage of the tool. This tool is available to the space physics community. As configured, the tool is basically complete for shock analysis; however, work continues to generalize SDAT for the analysis of other types of discontinuities.

  4. Subcell resolution in simplex stochastic collocation for spatial discontinuities

    SciTech Connect

    Witteveen, Jeroen A.S.; Iaccarino, Gianluca

    2013-10-15

    Subcell resolution has been used in the Finite Volume Method (FVM) to obtain accurate approximations of discontinuities in the physical space. Stochastic methods are usually based on local adaptivity for resolving discontinuities in the stochastic dimensions. However, the adaptive refinement in the probability space is ineffective in the non-intrusive uncertainty quantification framework, if the stochastic discontinuity is caused by a discontinuity in the physical space with a random location. The dependence of the discontinuity location in the probability space on the spatial coordinates then results in a staircase approximation of the statistics, which leads to first-order error convergence and an underprediction of the maximum standard deviation. To avoid these problems, we introduce subcell resolution into the Simplex Stochastic Collocation (SSC) method for obtaining a truly discontinuous representation of random spatial discontinuities in the interior of the cells discretizing the probability space. The presented SSC–SR method is based on resolving the discontinuity location in the probability space explicitly as function of the spatial coordinates and extending the stochastic response surface approximations up to the predicted discontinuity location. The applications to a linear advection problem, the inviscid Burgers’ equation, a shock tube problem, and the transonic flow over the RAE 2822 airfoil show that SSC–SR resolves random spatial discontinuities with multiple stochastic and spatial dimensions accurately using a minimal number of samples.

  5. LAB and other lithospheric discontinuities below Cratons

    NASA Astrophysics Data System (ADS)

    Sodoudi, Forough

    2013-04-01

    Cratons are extremely stable continental areas of the Earth's crust, which have been formed and remained largely unchanged since Precambrian. However, their formation and how they survived destruction over billions of years remains a subject of debate. Seismic properties of the cratonic lithosphere reflect its composition and physical state and obtain basic constraints on processes of the formation and evolution of continents. Insight on these issues may be gained by determining the depth and the nature of the Lithosphere-Asthenosphere Boundary (LAB), which is a necessary element of the plate tectonic theory. However, It has proved quite "elusive" beneath the oldest continental areas. What is missing to date is a consensus on the feature that would correspond to the LAB and whether such a feature exists everywhere beneath cratons. The relatively recently developed S receiver function technique employing S-to-P conversions appears promising for detecting the LAB with a sufficiently high resolution and density. A growing number of regional observations obtained from S receiver function studies has detected discontinuities characterized by a significant negative velocity contrast in the upper mantle. However, challenges still remain in detecting the S-to-P conversions from the LAB beneath the Precambrian cratons. Some recent SRF studies observed a deep (> 160 km) negative velocity contrast beneath cratons and interpreted it as the LAB. For example, a deep LAB at about 250 km was reported beneath the Kalahari craton by different authors. Similar results were also obtained beneath some parts of the Canadian shield, East European Craton, Australia, the Arabian Shield and Tanzania craton. In contrast, other SRF studies found no evidence for negative discontinuities at these depths in the North American craton, in Kalahari craton or in Australia. Instead they revealed a very sharp negative velocity gradient at much shallower depth (60-150 km), leading some authors to infer

  6. Syllabic (~2-5 Hz) and fluctuation (~1-10 Hz) ranges in speech and auditory processing

    PubMed Central

    Edwards, Erik; Chang, Edward F.

    2013-01-01

    Given recent interest in syllabic rates (~2-5 Hz) for speech processing, we review the perception of “fluctuation” range (~1-10 Hz) modulations during listening to speech and technical auditory stimuli (AM and FM tones and noises, and ripple sounds). We find evidence that the temporal modulation transfer function (TMTF) of human auditory perception is not simply low-pass in nature, but rather exhibits a peak in sensitivity in the syllabic range (~2-5 Hz). We also address human and animal neurophysiological evidence, and argue that this bandpass tuning arises at the thalamocortical level and is more associated with non-primary regions than primary regions of cortex. The bandpass rather than low-pass TMTF has implications for modeling auditory central physiology and speech processing: this implicates temporal contrast rather than simple temporal integration, with contrast enhancement for dynamic stimuli in the fluctuation range. PMID:24035819

  7. Comparison of the Effects of 1 Hz and 20 Hz rTMS on Motor Recovery in Subacute Stroke Patients

    PubMed Central

    Kim, Chul; Choi, Hee Eun; Lee, Byeong-Ju; Lee, Ki Hoon; Lim, Young-Joon

    2014-01-01

    Objective To compare the low frequency (1 Hz) repetitive transcranial magnetic stimulation (rTMS) with high frequency (20 Hz) rTMS on motor functional improvement of the affected upper extremity in subacute stroke patients. Methods Forty patients with subacute ischemic stroke participated in this study. The first group received 10 sessions of 20 Hz rTMS at ipsilesional M1 area and the other group received 10 sessions of 1 Hz rTMS at contralesional M1 area. Motor training of the hemiparetic hand was conducted after each rTMS train. All the patients received conventional occupational therapy immediately after each rTMS session. Manual function test (MFT), Fugl-Meyer Assessment scale (FMS), Modified Barthel Index (MBI), Brunnstrom recovery stage, and grip strength were used to assess motor function before, at the end of, and one month after the last session of rTMS. Results No adverse side effects were reported during the course of the experiment using rTMS. No significant difference in motor function of the affected upper extremity was observed between the two groups before rTMS. Significant improvements in MFT, FMS, MBI, and Brunnstrom stage were observed in the both groups at the end of the last rTMS session and one month later (p<0.05). No significant difference was found between the two groups (p>0.05). Conclusion There was no significant difference in motor function of the affected upper extremity between 1 Hz and 20 Hz rTMS during the subacute period of ischemic stroke. Thus, we cannot conclude which has a greater effect. PMID:25379487

  8. Evaluation of the economic burden of Herpes Zoster (HZ) infection

    PubMed Central

    Panatto, Donatella; Bragazzi, Nicola Luigi; Rizzitelli, Emanuela; Bonanni, Paolo; Boccalini, Sara; Icardi, Giancarlo; Gasparini, Roberto; Amicizia, Daniela

    2014-01-01

    The main objective of this systematic review was to evaluate the economic burden of Herpes Zoster (HZ) infection. The review was conducted in accordance with the standards of the “Preferred Reporting Items for Systematic Reviews and Meta-Analyses” guidelines. The following databases were accessed: ISI/Web of Knowledge (WoS), MEDLINE/PubMed, Scopus, ProQuest, the Cochrane Library and EconLit. Specific literature on health economics was also manually inspected. Thirty-three studies were included. The quality of the studies assessed in accordance with the Consolidated Health Economic Evaluation Reporting Standards checklist was good. All studies evaluated direct costs, apart from one which dealt only with indirect costs. Indirect costs were evaluated by 12 studies. The economic burden of HZ has increased over time. HZ management and drug prescriptions generate the highest direct costs. While increasing age, co-morbidities and drug treatment were found to predict higher direct costs, being employed was correlated with higher indirect costs, and thus with the onset age of the disease. Despite some differences among the selected studies, particularly with regard to indirect costs, all concur that HZ is a widespread disease which has a heavy social and economic burden. PMID:25483704

  9. Evaluation of the economic burden of Herpes Zoster (HZ) infection.

    PubMed

    Panatto, Donatella; Bragazzi, Nicola Luigi; Rizzitelli, Emanuela; Bonanni, Paolo; Boccalini, Sara; Icardi, Giancarlo; Gasparini, Roberto; Amicizia, Daniela

    2015-01-01

    The main objective of this systematic review was to evaluate the economic burden of Herpes Zoster (HZ) infection.   The review was conducted in accordance with the standards of the "Preferred Reporting Items for Systematic Reviews and Meta-Analyses" guidelines. The following databases were accessed: ISI/Web of Knowledge (WoS), MEDLINE/PubMed, Scopus, ProQuest, the Cochrane Library and EconLit. Specific literature on health economics was also manually inspected. Thirty-three studies were included. The quality of the studies assessed in accordance with the Consolidated Health Economic Evaluation Reporting Standards checklist was good. All studies evaluated direct costs, apart from one which dealt only with indirect costs. Indirect costs were evaluated by 12 studies. The economic burden of HZ has increased over time. HZ management and drug prescriptions generate the highest direct costs. While increasing age, co-morbidities and drug treatment were found to predict higher direct costs, being employed was correlated with higher indirect costs, and thus with the onset age of the disease. Despite some differences among the selected studies, particularly with regard to indirect costs, all concur that HZ is a widespread disease which has a heavy social and economic burden.

  10. A 40-Hz Auditory Potential Recorded from the Human Scalp

    NASA Astrophysics Data System (ADS)

    Galambos, Robert; Makeig, Scott; Talmachoff, Peter J.

    1981-04-01

    Computer techniques readily extract from the brainwaves an orderly sequence of brain potentials locked in time to sound stimuli. The potentials that appear 8 to 80 msec after the stimulus resemble 3 or 4 cycles of a 40-Hz sine wave; we show here that these waves combine to form a single, stable, composite wave when the sounds are repeated at rates around 40 per sec. This phenomenon, the 40-Hz event-related potential (ERP), displays several properties of theoretical and practical interest. First, it reportedly disappears with surgical anesthesia, and it resembles similar phenomena in the visual and olfactory system, facts which suggest that adequate processing of sensory information may require cyclical brain events in the 30- to 50-Hz range. Second, latency and amplitude measurements on the 40-Hz ERP indicate it may contain useful information on the number and basilar membrane location of the auditory nerve fibers a given tone excites. Third, the response is present at sound intensities very close to normal adult thresholds for the audiometric frequencies, a fact that could have application in clinical hearing testing.

  11. Augmented proper orthogonal decompositional for problems with moving discontinuities

    SciTech Connect

    Brenner, T.; Fontenot, R.; Cizmas, P.; O'Brien, T.; Breault, R.

    2010-01-01

    A method is proposed to augment the proper orthogonaldecomposition basis functionswith discontinuitymodes to better capture moving discontinuities in reduced-order models. Moving discontinuities can be shocks in unsteady gas flows or bubbles in multiphase flow. The method is shown to work for a simple test problem using the first-order wave equation. A method for detecting discontinuities numerically is developed using mathematical morphology. This method is shown to properly identify the edges of bubbles in multiphase flow.

  12. A General approach for calculating coupling impedances of small discontinuities

    NASA Astrophysics Data System (ADS)

    Kurennoy, Sergei S.; Gluckstern, Robert L.; Stupakov, Gennady V.

    A general theory of the beam interaction with small discontinuities of the vacuum chamber is developed taking into account the reaction of radiated waves back on the discontinuity. The reactive impedance calculated earlier is reproduced as the first order, and the resistive one as the second order of a perturbation theory based on this general approach. The theory also gives, in a very natural way, the results for the trapped modes due to small discontinuities obtained earlier by a different method.

  13. Universal quantum computation by discontinuous quantum walk

    SciTech Connect

    Underwood, Michael S.; Feder, David L.

    2010-10-15

    Quantum walks are the quantum-mechanical analog of random walks, in which a quantum ''walker'' evolves between initial and final states by traversing the edges of a graph, either in discrete steps from node to node or via continuous evolution under the Hamiltonian furnished by the adjacency matrix of the graph. We present a hybrid scheme for universal quantum computation in which a quantum walker takes discrete steps of continuous evolution. This ''discontinuous'' quantum walk employs perfect quantum-state transfer between two nodes of specific subgraphs chosen to implement a universal gate set, thereby ensuring unitary evolution without requiring the introduction of an ancillary coin space. The run time is linear in the number of simulated qubits and gates. The scheme allows multiple runs of the algorithm to be executed almost simultaneously by starting walkers one time step apart.

  14. Discontinuous Galerkin Methods for Turbulence Simulation

    NASA Technical Reports Server (NTRS)

    Collis, S. Scott

    2002-01-01

    A discontinuous Galerkin (DG) method is formulated, implemented, and tested for simulation of compressible turbulent flows. The method is applied to turbulent channel flow at low Reynolds number, where it is found to successfully predict low-order statistics with fewer degrees of freedom than traditional numerical methods. This reduction is achieved by utilizing local hp-refinement such that the computational grid is refined simultaneously in all three spatial coordinates with decreasing distance from the wall. Another advantage of DG is that Dirichlet boundary conditions can be enforced weakly through integrals of the numerical fluxes. Both for a model advection-diffusion problem and for turbulent channel flow, weak enforcement of wall boundaries is found to improve results at low resolution. Such weak boundary conditions may play a pivotal role in wall modeling for large-eddy simulation.

  15. Weld stresses beyond elastic limit: Materials discontinuity

    NASA Technical Reports Server (NTRS)

    Verderaime, V.

    1989-01-01

    When welded structures depend on properties beyond the elastic limit to qualify their ultimate safety factor, and weld-parent materials abruptly change at the interface, then stress discontinuity is inevitable. The stress concentration is mildly sensitive to material relative strain hardening and acutely sensitive to applied stress fields. Peak stresses occur on the weld surface, at the interface, and dissipate within a 0.01-inch band. When the stress is intense, the weld will always fracture at the interface. The analysis incorporates a classical mechanics model to more sharply define stress spikes within the bandwidth, and suggests a relative material index and Poisson's ratio related to strain hardening. Implications are discussed which are applicable to industries of high performance structures.

  16. Capillary breakup of discontinuously rate thickening suspensions.

    PubMed

    Zimoch, Pawel J; McKinley, Gareth H; Hosoi, A E

    2013-07-19

    Using discontinuously rate thickening suspensions (DRTS) as a model system, we show that beads-on-a-string morphologies can arise as a result of external viscous drag acting during capillary-driven breakup of a non-Newtonian fluid. To minimize the perturbative effect of gravity, we developed a new experimental test platform in which the filament is supported in a horizontal position at the surface of an immiscible oil bath. We show that the evolution of thin DRTS filaments during the capillary thinning process is well described by a set of one-dimensional slender filament equations. The strongly rate-dependent rheology of the test fluid and the aspect ratio of the filament couple to control the thinning dynamics and lead to a simple criterion describing the localized arrest of the capillary thinning process and the subsequent formation of complex, high aspect ratio beads-on-a-string structures. PMID:23909338

  17. Evolution equation for infinitesimal rotational discontinuities

    NASA Technical Reports Server (NTRS)

    Sonnerup, B. U. O.; Qian, S.; Wang, D.-J.

    1990-01-01

    An evolution equation in the form of a modified Korteweg-de Vries equation is developed which describes the small-amplitude version of the infinitesimal rotational discontinuity (RD) studied by Wang and Sonnerup (1984). It is shown that the small-amplitude version of the equilibrium pulse solution obtained by Wang and Sonnerup is metastable and thus unlikely to arise spontaneously. When the initial pulse amplitude is smaller than and/or the initial pulse width is greater than the equilibrium value, the pulse decays. When the reverse is the case, the pulse is converted to an infinitesimal intermediate-mode solitary wave having greater pulse amplitude and speed. A simulation experiment is performed in which one of the equilibrium intermediate-mode solitary waves overtakes another, less rapidly moving version of the same wave. The existence of multipeaked intermediate-mode solitary pulses is demonstrated.

  18. From weak discontinuities to nondissipative shock waves

    SciTech Connect

    Garifullin, R. N. Suleimanov, B. I.

    2010-01-15

    An analysis is presented of the effect of weak dispersion on transitions from weak to strong discontinuities in inviscid fluid dynamics. In the neighborhoods of transition points, this effect is described by simultaneous solutions to the Korteweg-de Vries equation u{sub t}'+ uu{sub x}' + u{sub xxx}' = 0 and fifth-order nonautonomous ordinary differential equations. As x{sup 2} + t{sup 2} {yields}{infinity}, the asymptotic behavior of these simultaneous solutions in the zone of undamped oscillations is given by quasi-simple wave solutions to Whitham equations of the form r{sub i}(t, x) = tl{sub i} x/t{sup 2}.

  19. DISCONTINUED OR LITTLE USED LARGE GATE VALVE AND VALVE ASSEMBLY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DISCONTINUED OR LITTLE USED LARGE GATE VALVE AND VALVE ASSEMBLY PATTERNS, PATTERN STORAGE BUILDING. - Stockham Pipe & Fittings Company, Pattern Storage, 4000 Tenth Avenue North, Birmingham, Jefferson County, AL

  20. Analysis of Waveguide Junction Discontinuities Using Finite Element Method

    NASA Technical Reports Server (NTRS)

    Deshpande, Manohar D.

    1997-01-01

    A Finite Element Method (FEM) is presented to determine reflection and transmission coefficients of rectangular waveguide junction discontinuities. An H-plane discontinuity, an E-plane ridge discontinuity, and a step discontinuity in a concentric rectangular waveguide junction are analyzed using the FEM procedure. Also, reflection and transmission coefficients due to presence of a gap between two sections of a rectangular waveguide are determined using the FEM. The numerical results obtained by the present method are in excellent agreement with the earlier published results. The numerical results obtained by the FEM are compared with the numerical results obtained using the Mode Matching Method (MMM) and also with the measured data.

  1. MHD discontinuities in solar flares: Continuous transitions and plasma heating

    NASA Astrophysics Data System (ADS)

    Ledentsov, L. S.; Somov, B. V.

    2015-12-01

    The boundary conditions for the ideal MHD equations on a plane discontinuity surface are investigated. It is shown that, for a given mass flux through a discontinuity, its type depends only on the relation between inclination angles of a magnetic field. Moreover, the conservation laws on a surface of discontinuity allow changing a discontinuity type with gradual (continuous) changes in the conditions of plasma flow. Then there are the so-called transition solutions that satisfy simultaneously two types of discontinuities. We obtain all transition solutions on the basis of the complete system of boundary conditions for the MHD equations. We also found the expression describing a jump of internal energy of the plasma flowing through the discontinuity. Firstly, this allows constructing a generalized scheme of possible continuous transitions between MHD discontinuities. Secondly, it enables the examination of the dependence of plasma heating by plasma density and configuration of the magnetic field near the discontinuity surface, i.e., by the type of the MHD discontinuity. It is shown that the best conditions for heating are carried out in the vicinity of a reconnecting current layer near the areas of reverse currents. The result can be helpful in explaining the temperature distributions inside the active regions in the solar corona during flares observed by modern space observatories in soft and hard X-rays.

  2. Discontinuities detection using transmission electrical resistivity imaging

    NASA Astrophysics Data System (ADS)

    Lesparre, Nolwenn; Cabrera, Justo; Boyle, Alistair; Grychtol, Bartłomiej; Adler, Andy

    2015-04-01

    In the context of nuclear waste storage, low permeability clays are investigated as potential geological barrier. Discontinuities in such formations might facilitate the radionuclide transport to the environment. The underground platform of Tournemire (Aveyron, France) presents the opportunity to perform in-situ experiments to evaluate the potential of geophysical methods to detect and characterize the presence of discontinuities in the sub-surface. In this work, we apply transmission electrical resistivity tomography to image the medium surrounding a regional fault. A specific array of electrodes were set up, adapted for the characterization of the fault. Electrodes were placed along the tunnel as well as at the surface above the tunnel on both sides of the fault. The objective of a such geometry is to acquire data in transmission across the massif in addition to classical protocol such as Schlumberger or dipole-dipole in order to better cover the sounded medium. 3D models considering the gallery geometry, the topography and the injection of current in transmission through the massif were developed for the analysis of such particular data sets. For the reconstruction of the medium electrical resistivity, the parametrization of the inverse problem was adapted to the geometry of the experience in a scope to reduce the inversion under-determination. The resulting image obtained with classical protocols and transmission current injection is compared to an image obtained using only classical protocols to better highlight the interest of a transmission experiment in terms of resolution and penetration depth. The addition of protocols in transmission allows a better coverage of the sounded medium so the resulting image presents a better resolution at higher depths than the image resulting from a single profile of electrodes. The proposed configuration of electrical resistivity measurements in transmission is then promising for hydrogeophysical studies, in particular for

  3. Mantle Transition Zone Discontinuities Beneath Alaska

    NASA Astrophysics Data System (ADS)

    Dahm, H. H.; Gao, S. S.; Liu, K. H.; Yang, B.

    2015-12-01

    The 410 and 660 km discontinuities (d410 and d660) beneath Alaska and adjacent areas are imaged by stacking radial receiver functions recorded by about 400 broadband seismic stations with up to 30 years of recording period, using the 1D IASP91 earth model. Significant and spatially systematic variations in the apparent depths of the d410 and d660 are observed. The mean apparent depth of d410 and d660 for the entire study area is 416±1.87 km and 664±1.83 km, respectively. The variations of the apparent depths of d410 and d660 result in a complex mantle transition zone (MTZ) structure. Central and south-central Alaska are characterized by a normal MTZ thickness, suggesting that the subducting Pacific slab does not thermally affect the upper MTZ. Beneath the Yakutat microplate, a complex MTZ structure is observed with an overall thin MTZ thickness, coinciding with a low velocity zone and thin lithospheric thickness revealed by previous seismic tomography and receiver function studies. Two large regions with hot MTZ are mapped beneath NNW and NNE Alaska with abnormal temperature ranges between +360 and +390 °K. Despite of the complexity of the MTZ structure beneath Alaska, the mean MTZ thickness for the entire Alaskan orocline is 247 ±2.76 km, suggesting normal MTZ temperature on average. For the majority of the areas, our study shows that lateral upper mantle velocity variations contribute the bulk of the observed apparent undulations of the MTZ discontinuities.

  4. PROCEEDINGS OF THE WEST COAST REGIONAL CONFERENCE ON RESEARCH RELATED TO BLIND AND SEVERELY VISUALLY IMPAIRED CHILDREN (SAN FRANCISCO, MARCH 8-10, 1965).

    ERIC Educational Resources Information Center

    CLARK, LESLIE L.; AND OTHERS

    THESE PROCEEDINGS WERE PREPARED FROM THE WEST COAST REGIONAL CONFERENCE ON RESEARCH RELATED TO BLIND AND SEVERELY VISUALLY IMPAIRED CHILDREN HELD MARCH 8-10, 1965. SURVEY RESULTS WERE PRESENTED WHICH INDICATED THE NUMBER OF BLIND, SEVERELY VISUALLY IMPAIRED, AND MULTIPLY HANDICAPPED CHILDREN IN CALIFORNIA AND THE INCIDENCE OF BLINDNESS IN CHILDREN…

  5. A Double-Blind, Placebo-Controlled Study Investigating the Effects of Omega-3 Supplementation in Children Aged 8-10 Years from a Mainstream School Population

    ERIC Educational Resources Information Center

    Kirby, A.; Woodward, A.; Jackson, S.; Wang, Y.; Crawford, M. A.

    2010-01-01

    Despite the increased interest in the effects of omega-3 supplementation on childrens' learning and behaviour, there are a lack of controlled studies of this kind that have utilised a typically developing population. This study investigated the effects of omega-3 supplementation in 450 children aged 8-10 years old from a mainstream school…

  6. 40 CFR 721.10024 - 10H-Phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...-branched alkyl) derivs. 721.10024 Section 721.10024 Protection of Environment ENVIRONMENTAL PROTECTION... alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as 10H-phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs (PMN P-01-771; CAS...

  7. 40 CFR 721.10024 - 10H-Phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-branched alkyl) derivs. 721.10024 Section 721.10024 Protection of Environment ENVIRONMENTAL PROTECTION... alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as 10H-phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs (PMN P-01-771; CAS...

  8. 40 CFR 721.10024 - 10H-Phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...-branched alkyl) derivs. 721.10024 Section 721.10024 Protection of Environment ENVIRONMENTAL PROTECTION... alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as 10H-phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs (PMN P-01-771; CAS...

  9. 40 CFR 721.10024 - 10H-Phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...-branched alkyl) derivs. 721.10024 Section 721.10024 Protection of Environment ENVIRONMENTAL PROTECTION... alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as 10H-phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs (PMN P-01-771; CAS...

  10. 40 CFR 721.10024 - 10H-Phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...-branched alkyl) derivs. 721.10024 Section 721.10024 Protection of Environment ENVIRONMENTAL PROTECTION... alkyl) derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as 10H-phenothiazine, ar-(C9-rich C8-10-branched alkyl) derivs (PMN P-01-771; CAS...

  11. PROCEEDINGS AND SUMMARY REPORT: WORKSHOP ON THE FATE, TRANSPORT, AND TRANSFORMATION OF MERCURY IN AQUATIC AND TERRESTRIAL ENVIRONMENTS, MAY 8-10, 2001, WEST PALM BEACH, FLORIDA

    EPA Science Inventory

    The Workshop on the Fate, Transport, and Transformation of Mercury in Aquatic and Terrestrial Environments was held on May 8-10, 2001 in West Palm Beach, Florida. The workshop was conducted by the USEPA's Office of Research and Development and cosponsored by the U.S. Geological S...

  12. Outcomes of a School-Based Intervention (RESCATE) to Improve Physical Activity Patterns in Mexican Children Aged 8-10 Years

    ERIC Educational Resources Information Center

    Colin-Ramirez, E.; Castillo-Martinez, L.; Orea-Tejeda, A.; Vergara-Castaneda, A.; Keirns-Davis, C.; Villa-Romero, A.

    2010-01-01

    The aim of this study was to evaluate the impact of an intervention program on the patterns of physical activity in 8- to 10-year-old Mexican children from lower socioeconomic status. This study performed a randomized controlled field trial in 498 children aged 8-10 years from 10 public schools of low socioeconomic status in Mexico City. Schools…

  13. 40 CFR 180.1126 - Codlure, (E,E)-8,10-Dodecadien-1-ol; exemption from the requirement of a tolerance.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... RESIDUES IN FOOD Exemptions From Tolerances § 180.1126 Codlure, (E,E)-8,10-Dodecadien-1-ol; exemption from... inadvertent physical contact. The design of the dispenser must be such as to preclude any exposure of its components to the raw agricultural commodity (RAC) or processed foods/feeds derived from the commodity due...

  14. Discontinuation of buprenorphine maintenance therapy: perspectives and outcomes.

    PubMed

    Bentzley, Brandon S; Barth, Kelly S; Back, Sudie E; Book, Sarah W

    2015-05-01

    Buprenorphine maintenance therapy (BMT) is increasingly the preferred opioid maintenance agent due to its reduced toxicity and availability in an office-based setting in the United States. Although BMT has been shown to be highly efficacious, it is often discontinued soon after initiation. No current systematic review has yet investigated providers' or patients' reasons for BMT discontinuation or the outcomes that follow. Hence, provider and patient perspectives associated with BMT discontinuation after a period of stable buprenorphine maintenance and the resultant outcomes were systematically reviewed with specific emphasis on pre-buprenorphine-taper parameters predictive of relapse following BMT discontinuation. Few identified studies address provider or patient perspectives associated with buprenorphine discontinuation. Within the studies reviewed providers with residency training in BMT were more likely to favor long term BMT instead of detoxification, and providers were likely to consider BMT discontinuation in the face of medication misuse. Patients often desired to remain on BMT because of fear of relapse to illicit opioid use if they were to discontinue BMT. The majority of patients who discontinued BMT did so involuntarily, often due to failure to follow strict program requirements, and 1 month following discontinuation, rates of relapse to illicit opioid use exceeded 50% in every study reviewed. Only lower buprenorphine maintenance dose, which may be a marker for attenuated addiction severity, predicted better outcomes across studies. Relaxed BMT program requirements and frequent counsel on the high probability of relapse if BMT is discontinued may improve retention in treatment and prevent the relapse to illicit opioid use that is likely to follow BMT discontinuation.

  15. Humans perceive flicker artifacts at 500 Hz.

    PubMed

    Davis, James; Hsieh, Yi-Hsuan; Lee, Hung-Chi

    2015-02-03

    Humans perceive a stable average intensity image without flicker artifacts when a television or monitor updates at a sufficiently fast rate. This rate, known as the critical flicker fusion rate, has been studied for both spatially uniform lights, and spatio-temporal displays. These studies have included both stabilized and unstablized retinal images, and report the maximum observable rate as 50-90 Hz. A separate line of research has reported that fast eye movements known as saccades allow simple modulated LEDs to be observed at very high rates. Here we show that humans perceive visual flicker artifacts at rates over 500 Hz when a display includes high frequency spatial edges. This rate is many times higher than previously reported. As a result, modern display designs which use complex spatio-temporal coding need to update much faster than conventional TVs, which traditionally presented a simple sequence of natural images.

  16. Sounds in the ocean at 1-100 Hz.

    PubMed

    Wilcock, William S D; Stafford, Kathleen M; Andrew, Rex K; Odom, Robert I

    2014-01-01

    Very-low-frequency sounds between 1 and 100 Hz propagate large distances in the ocean sound channel. Weather conditions, earthquakes, marine mammals, and anthropogenic activities influence sound levels in this band. Weather-related sounds result from interactions between waves, bubbles entrained by breaking waves, and the deformation of sea ice. Earthquakes generate sound in geologically active regions, and earthquake T waves propagate throughout the oceans. Blue and fin whales generate long bouts of sounds near 20 Hz that can dominate regional ambient noise levels seasonally. Anthropogenic sound sources include ship propellers, energy extraction, and seismic air guns and have been growing steadily. The increasing availability of long-term records of ocean sound will provide new opportunities for a deeper understanding of natural and anthropogenic sound sources and potential interactions between them. PMID:23876176

  17. Sounds in the ocean at 1-100 Hz.

    PubMed

    Wilcock, William S D; Stafford, Kathleen M; Andrew, Rex K; Odom, Robert I

    2014-01-01

    Very-low-frequency sounds between 1 and 100 Hz propagate large distances in the ocean sound channel. Weather conditions, earthquakes, marine mammals, and anthropogenic activities influence sound levels in this band. Weather-related sounds result from interactions between waves, bubbles entrained by breaking waves, and the deformation of sea ice. Earthquakes generate sound in geologically active regions, and earthquake T waves propagate throughout the oceans. Blue and fin whales generate long bouts of sounds near 20 Hz that can dominate regional ambient noise levels seasonally. Anthropogenic sound sources include ship propellers, energy extraction, and seismic air guns and have been growing steadily. The increasing availability of long-term records of ocean sound will provide new opportunities for a deeper understanding of natural and anthropogenic sound sources and potential interactions between them.

  18. 600-Hz linewidth short-linear-cavity fiber laser.

    PubMed

    Mo, Shupei; Huang, Xiang; Xu, Shanhui; Li, Can; Yang, Changsheng; Feng, Zhouming; Zhang, Weinan; Chen, Dongdan; Yang, Zhongmin

    2014-10-15

    We proposed a short-linear-cavity (SLC) fiber laser based on a virtual-folded-ring (VFR) resonator and a fiber Bragg grating Fabry-Perot filter. Spatial hole burning effect was reduced by retarding the polarization state of the counter-propagating light waves utilizing the VFR structure. The photon lifetime of the resonator was extended due to the multi-reflection inside the FBG FP, which increased the intra-cavity power and relatively suppressed the contribution of phase diffusion from spontaneous emission. The relaxation oscillation frequency is around 160 kHz due to the slow light effect. The linewidth of the SLC fiber laser was measured to be less than 600 Hz.

  19. The 10 Hz Frequency: A Fulcrum For Transitional Brain States

    PubMed Central

    Garcia-Rill, E.; D’Onofrio, S.; Luster, B.; Mahaffey, S.; Urbano, F. J.; Phillips, C.

    2016-01-01

    A 10 Hz rhythm is present in the occipital cortex when the eyes are closed (alpha waves), in the precentral cortex at rest (mu rhythm), in the superior and middle temporal lobe (tau rhythm), in the inferior olive (projection to cerebellar cortex), and in physiological tremor (underlying all voluntary movement). These are all considered resting rhythms in the waking brain which are “replaced” by higher frequency activity with sensorimotor stimulation. That is, the 10 Hz frequency fulcrum is replaced on the one hand by lower frequencies during sleep, or on the other hand by higher frequencies during volition and cognition. The 10 Hz frequency fulcrum is proposed as the natural frequency of the brain during quiet waking, but is replaced by higher frequencies capable of permitting more complex functions, or by lower frequencies during sleep and inactivity. At the center of the transition shifts to and from the resting rhythm is the reticular activating system, a phylogenetically preserved area of the brain essential for preconscious awareness. PMID:27547831

  20. 25 CFR 175.21 - Discontinuance of service.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Discontinuance of service. 175.21 Section 175.21 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN ELECTRIC POWER UTILITIES Utility Service Administration § 175.21 Discontinuance of service. Failure of customer(s) to comply...

  1. 25 CFR 175.21 - Discontinuance of service.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Discontinuance of service. 175.21 Section 175.21 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN ELECTRIC POWER UTILITIES Utility Service Administration § 175.21 Discontinuance of service. Failure of customer(s) to comply...

  2. 25 CFR 175.21 - Discontinuance of service.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Discontinuance of service. 175.21 Section 175.21 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN ELECTRIC POWER UTILITIES Utility Service Administration § 175.21 Discontinuance of service. Failure of customer(s) to comply...

  3. 25 CFR 175.21 - Discontinuance of service.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Discontinuance of service. 175.21 Section 175.21 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN ELECTRIC POWER UTILITIES Utility Service Administration § 175.21 Discontinuance of service. Failure of customer(s) to comply...

  4. 25 CFR 175.21 - Discontinuance of service.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Discontinuance of service. 175.21 Section 175.21 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN ELECTRIC POWER UTILITIES Utility Service Administration § 175.21 Discontinuance of service. Failure of customer(s) to comply...

  5. 27 CFR 19.19 - Discontinuance of storage facilities.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Discontinuance of storage... Provisions § 19.19 Discontinuance of storage facilities. If TTB determines that a proprietor's bonded storage... spirits stored in the facility to another storage facility. The transfer will take place at such time...

  6. 27 CFR 19.79 - Discontinuance of storage facilities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Discontinuance of storage... Provisions Activities Not Subject to This Part § 19.79 Discontinuance of storage facilities. When the appropriate TTB officer finds that any facilities for the storage of spirits on bonded premises are unsafe...

  7. 27 CFR 19.19 - Discontinuance of storage facilities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Discontinuance of storage... Provisions § 19.19 Discontinuance of storage facilities. If TTB determines that a proprietor's bonded storage... spirits stored in the facility to another storage facility. The transfer will take place at such time...

  8. 7 CFR 247.17 - Notification of discontinuance of participant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Notification of discontinuance of participant. 247.17 Section 247.17 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.17 Notification of discontinuance...

  9. 7 CFR 247.17 - Notification of discontinuance of participant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Notification of discontinuance of participant. 247.17 Section 247.17 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.17 Notification of discontinuance...

  10. 7 CFR 247.17 - Notification of discontinuance of participant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Notification of discontinuance of participant. 247.17 Section 247.17 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.17 Notification of discontinuance...

  11. 27 CFR 25.85 - Notice of permanent discontinuance.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Notice of permanent discontinuance. 25.85 Section 25.85 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL BEER Qualification of a Brewery Discontinuance of...

  12. 27 CFR 25.85 - Notice of permanent discontinuance.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Notice of permanent discontinuance. 25.85 Section 25.85 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Qualification of a Brewery Discontinuance of...

  13. 27 CFR 25.85 - Notice of permanent discontinuance.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Notice of permanent discontinuance. 25.85 Section 25.85 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Qualification of a Brewery Discontinuance of...

  14. 27 CFR 25.85 - Notice of permanent discontinuance.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Notice of permanent discontinuance. 25.85 Section 25.85 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL BEER Qualification of a Brewery Discontinuance of...

  15. 27 CFR 25.85 - Notice of permanent discontinuance.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Notice of permanent discontinuance. 25.85 Section 25.85 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Qualification of a Brewery Discontinuance of...

  16. 27 CFR 31.138 - Discontinuance of business.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Discontinuance of business. 31.138 Section 31.138 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU... § 31.138 Discontinuance of business. A dealer going out of business must register that event within...

  17. 27 CFR 72.37 - Discontinuance of administrative proceedings.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Discontinuance of administrative proceedings. 72.37 Section 72.37 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX... to effect such sale or retention will be discontinued....

  18. EVALUATING DISCONTINUITIES IN COMPLEX SYSTEMS: TOWARD QUANTITATIVE MEASURE OF RESILIENCE

    EPA Science Inventory

    The textural discontinuity hypothesis (TDH) is based on the observation that animal body mass distributions exhibit discontinuities that may reflect the texture of the landscape available for exploitation. This idea has been extended to other complex systems, hinting that the ide...

  19. Transition density of one-dimensional diffusion with discontinuous drift

    NASA Technical Reports Server (NTRS)

    Zhang, Weijian

    1990-01-01

    The transition density of a one-dimensional diffusion process with a discontinuous drift coefficient is studied. A probabilistic representation of the transition density is given, illustrating the close connections between discontinuities of the drift and Brownian local times. In addition, some explicit results are obtained based on the trivariate density of Brownian motion, its occupation, and local times.

  20. Auditory discontinuities interact with categorization: Implications for speech perception

    NASA Astrophysics Data System (ADS)

    Holt, Lori L.; Lotto, Andrew J.; Diehl, Randy L.

    2004-09-01

    Behavioral experiments with infants, adults, and nonhuman animals converge with neurophysiological findings to suggest that there is a discontinuity in auditory processing of stimulus components differing in onset time by about 20 ms. This discontinuity has been implicated as a basis for boundaries between speech categories distinguished by voice onset time (VOT). Here, it is investigated how this discontinuity interacts with the learning of novel perceptual categories. Adult listeners were trained to categorize nonspeech stimuli that mimicked certain temporal properties of VOT stimuli. One group of listeners learned categories with a boundary coincident with the perceptual discontinuity. Another group learned categories defined such that the perceptual discontinuity fell within a category. Listeners in the latter group required significantly more experience to reach criterion categorization performance. Evidence of interactions between the perceptual discontinuity and the learned categories extended to generalization tests as well. It has been hypothesized that languages make use of perceptual discontinuities to promote distinctiveness among sounds within a language inventory. The present data suggest that discontinuities interact with category learning. As such, ``learnability'' may play a predictive role in selection of language sound inventories.

  1. 24 CFR 203.288 - Discontinuance of adjusted premium charge.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Discontinuance of adjusted premium... Premium § 203.288 Discontinuance of adjusted premium charge. Notwithstanding any provision in the mortgage instrument, there shall be no adjusted mortgage insurance premium due the Commissioner on account of...

  2. 27 CFR 21.3 - Stocks of discontinued formulas.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Stocks of discontinued..., DEPARTMENT OF THE TREASURY LIQUORS FORMULAS FOR DENATURED ALCOHOL AND RUM General Provisions § 21.3 Stocks of discontinued formulas. Denaturers, or specially denatured spirits dealers or users, having on hand stocks...

  3. Impact of solar wind tangential discontinuities on the Earth's magnetosphere

    NASA Astrophysics Data System (ADS)

    Grib, S. A.

    2012-12-01

    The collision of a solar wind tangential discontinuity with the bow shock and magnetopause is considered in the scope of an MHD approximation. Using MHD methods of trial calculations and generalized shock polars, it has been indicated that a fast shock refracted into the magnetosheath originates when density increases across a tangential discontinuity and a fast rarefaction wave is generated when density decreases at this discontinuity. It has been indicated that a shock front shift under the action of collisions with a tangential discontinuity is experimentally observed and a fast bow shock can be transformed into a slow shock. Using a specific event as an example, it has been demonstrated that solar wind tangential discontinuity affects the geomagnetic field behavior.

  4. Plasma field characteristics of directional discontinuities in the interplanetary medium

    NASA Technical Reports Server (NTRS)

    Solodyna, C. V.; Belcher, J. W.; Sari, J. W.

    1977-01-01

    The paper examines plasma and magnetic-field changes occurring across 1359 directional discontinuities taken from interplanetary data spanning almost four solar rotations. The plasma field characteristics of these events exhibit a distinct variation with large-scale solar-wind velocity. At low velocities, tangential discontinuities appear to predominate. At higher velocities, a substantial and increasing fraction of directional discontinuities exhibits the plasma field properties expected of outwardly propagating rotational discontinuities. The results of Sari (1972, 1975) and of the present study suggest that in the calculation of propagation diffusion coefficients for low-energy cosmic rays, the effects of directional discontinuities should be subtracted from the magnetic fluctuation spectrum during relatively quiet wind conditions. It is not clear that such subtraction is necessary during more disturbed periods.

  5. Improvements in GPS precision: 10 Hz to one day

    NASA Astrophysics Data System (ADS)

    Choi, Kyuhong

    Seeking to understand Global Positioning System (GPS) measurements and the positioning solutions in various time intervals, this dissertation improves the consistency of pseudorange measurements from different receiver types, processes 30 s interval data with optimized filtering techniques, and analyzes very-high-rate data with short arc lengths and baseline noise. The first project studies satellite-dependent biases between C/A and P1 codes. Calibrating these biases reduces the inconsistency of satellite clocks, improving the ambiguity resolution which allows for higher position precision. Receiver-dependent biases for two receivers are compared with the bias products of Center for Orbit Determination in Europe (CODE). Baseline lengths ranging up to ˜2,100km are tested with the receiver-specific biases; they resolve more phase ambiguity by 4.3% than using CODE's products. The second project analyzes 1 s and 30 s interval GPS data of the 2003 Tokachi-Oki earthquake. For 1 Hz positioning, Iterative Tropospheric Estimation (ITE) method improves vertical precision. While equalized sidereal filtering reduces noise for multipath-dominant 30--300 s periods, it can cause long-term drifts in the timeseries. A study of postseismic deformation after the Tokachi-Oki earthquake uses 30 s interval position estimations to test multiple filtering strategies to maximize precision using lower-rate data. On top of the residual stacking, estimation of a random walk constraint of sigmaDelta = 1.80 cm/ hr shows maximum noise reduction capability while retaining the real deformation signal. These techniques enhance our grasp of fault response in the aftermath of great earthquakes. The third project probes noise floor characteristics of very-high-rate (> 1 Hz) GPS data. A hybrid method, designed and tested to resolve phase biases, minimizes computational burdens while keeping the quality of ambiguity-fixed solutions. Noise characteristics are compared after an analysis of 5 and 10 Hz

  6. Stability of Dynamical Systems with Discontinuous Motions:

    NASA Astrophysics Data System (ADS)

    Michel, Anthony N.; Hou, Ling

    In this paper we present a stability theory for discontinuous dynamical systems (DDS): continuous-time systems whose motions are not necessarily continuous with respect to time. We show that this theory is not only applicable in the analysis of DDS, but also in the analysis of continuous dynamical systems (continuous-time systems whose motions are continuous with respect to time), discrete-time dynamical systems (systems whose motions are defined at discrete points in time) and hybrid dynamical systems (HDS) (systems whose descriptions involve simultaneously continuous-time and discrete-time). We show that the stability results for DDS are in general less conservative than the corresponding well-known classical Lyapunov results for continuous dynamical systems and discrete-time dynamical systems. Although the DDS stability results are applicable to general dynamical systems defined on metric spaces (divorced from any kind of description by differential equations, or any other kinds of equations), we confine ourselves to finite-dimensional dynamical systems defined by ordinary differential equations and difference equations, to make this paper as widely accessible as possible. We present only sample results, namely, results for uniform asymptotic stability in the large.

  7. Capillary surface discontinuities above reentrant corners

    NASA Technical Reports Server (NTRS)

    Korevaar, H. J.

    1982-01-01

    A particular configuration of a vertical capillary tube for which S is the equilibrium interface between two fluids in the presence of a downward pointing gravitational field was investigated. S is the graph a function u whose domain is the (horizontal) cross section gamma of the tube. The mean curvature of S is proportional to its height above a fixed reference plane and lambda is a prescribed constant and may be taken between zero and pi/2. Domains gamma for which us is a bounded function but does not extend continuously to d gamma are sought. Simple domains are found and the behavior of u in those domains is studied. An important comparison principle that has been used in the literature to derive many of the results in capillarity is reviewed. It allows one to deduce the approximate shape of a capillary surface by constructing comparison surfaces with mean curvature and contact angle close to those of the (unknown) solution surface. In the context of nonparametric problems the comparison principle leads to height estimates above and below for the function u. An example from the literature where these height estimates have been used successfully is described. The promised domains for which the bounded u does not extend continuously to the boundary are constructed. The point on the boundary at which u has a jump discontinuity will be the vertext of a re-entrant corner having any interior angle theta pi. Using the comparison principle the behavior of u near this point is studied.

  8. Discontinuous Galerkin Methods for Neutrino Radiation Transport

    NASA Astrophysics Data System (ADS)

    Endeve, Eirik; Hauck, Cory; Xing, Yulong; Mezzacappa, Anthony

    2015-04-01

    We are developing new computational methods for simulation of neutrino transport in core-collapse supernovae, which is challenging since neutrinos evolve from being diffusive in the proto-neutron star to nearly free streaming in the critical neutrino heating region. To this end, we consider conservative formulations of the Boltzmann equation, and aim to develop robust, high-order accurate methods. Runge-Kutta discontinuous Galerkin (DG) methods, offer several attractive properties, including (i) high-order accuracy on a compact stencil and (ii) correct asymptotic behavior in the diffusion limit. We have recently developed a new DG method for the advection part for the transport solve, which is high-order accurate and strictly preserves the physical bounds of the distribution function; i.e., f ∈ [ 0 , 1 ] . We summarize the main ingredients of our bound-preserving DG method and discuss ongoing work to include neutrino-matter interactions in the scheme. Research sponsored in part by Oak Ridge National Laboratory, managed by UT-Battelle, LLC for the U. S. Department of Energy

  9. Discontinuous jamming transition in driven foam

    NASA Astrophysics Data System (ADS)

    Dennin, Michael

    2007-03-01

    Aqueous foam (gas bubbles with liquid walls) is a surprising substance. Every molecule in foam is in a fluid state, either liquid or gas. Yet, the entire foam holds its shape as a solid would. In fact, when subjected to an applied strain at a slow enough strain rate, the initial response of the foam is the same as an elastic solid. On the other hand, under sufficiently large stress or strain, the foam can flow in a fashion similar to a fluid. This is similar to plastic flow that occurs in many ``molecular'' solids. In this talk, we will focus on experimental studies of the transition from solid behavior to flowing behavior, with an emphasis on to what degree this ``jamming'' transition is analogous to a ``real'' phase transition. We will focus on recent results using a model, two-dimensional foam: bubble rafts. Bubble rafts are a single layer of bubbles on the surface of water. By focusing on a two-dimensional system, it is relatively easy to track individual bubbles and gain insight into the connection between bubble dynamics (the mesoscopic scale) and the response of the entire foam (macroscopic scale). We will focus on recent measurements of a discontinuous transition from solid to fluid like behavior in the bubble raft.

  10. Airborne electromagnetic imaging of discontinuous permafrost

    USGS Publications Warehouse

    Minsley, B.J.; Abraham, J.D.; Smith, B.D.; Cannia, J.C.; Voss, C.I.; Jorgenson, M.T.; Walvoord, M.A.; Wylie, B.K.; Anderson, L.; Ball, L.B.; Deszcz-Pan, M.; Wellman, T.P.; Ager, T.A.

    2012-01-01

    The evolution of permafrost in cold regions is inextricably connected to hydrogeologic processes, climate, and ecosystems. Permafrost thawing has been linked to changes in wetland and lake areas, alteration of the groundwater contribution to streamflow, carbon release, and increased fire frequency. But detailed knowledge about the dynamic state of permafrost in relation to surface and groundwater systems remains an enigma. Here, we present the results of a pioneering ???1,800 line-kilometer airborne electromagnetic survey that shows sediments deposited over the past ???4 million years and the configuration of permafrost to depths of ???100 meters in the Yukon Flats area near Fort Yukon, Alaska. The Yukon Flats is near the boundary between continuous permafrost to the north and discontinuous permafrost to the south, making it an important location for examining permafrost dynamics. Our results not only provide a detailed snapshot of the present-day configuration of permafrost, but they also expose previously unseen details about potential surface-groundwater connections and the thermal legacy of surface water features that has been recorded in the permafrost over the past ???1,000 years. This work will be a critical baseline for future permafrost studies aimed at exploring the connections between hydrogeologic, climatic, and ecological processes, and has significant implications for the stewardship of Arctic environments. ?? 2012 by the American Geophysical Union.

  11. Polar constellations design for discontinuous coverage

    NASA Astrophysics Data System (ADS)

    Sarno, Salvatore; Graziano, Maria Daniela; D'Errico, Marco

    2016-10-01

    A novel constellation design method is developed for discontinuous coverage of the globe and polar caps. It integrates and extends the applicability of the coverage regions and mitigates the limitations of the existing techniques based on streets-of-coverage (SOC) theory. In particular, the visibility conditions of the targets are mapped in the (Ω, u)-domain to identify the number of satellites per plane and the distance between successive orbits, whereas the planes are arranged around the equator exploiting satellites both in ascending and descending phase. The proposed approach is applied to design potential space segments in polar LEO supporting the existing maritime surveillance services over the globe and on the future polar routes. Results show they require a smaller total number of satellites with respect to the SOC-based configurations for revisit times less than one hour and wide range of swaths. In details, it is observed a reduction between 6% and 22% for global coverage and between 24% and 33% for the coverage of polar caps.

  12. Splitting attention reduces temporal resolution from 7 Hz for tracking one object to <3 Hz when tracking three.

    PubMed

    Holcombe, Alex O; Chen, Wei-Ying

    2013-01-01

    Overall performance when tracking moving targets is known to be poorer for larger numbers of targets, but the specific effect on tracking's temporal resolution has never been investigated. We document a broad range of display parameters for which visual tracking is limited by temporal frequency (the interval between when a target is at each location and a distracter moves in and replaces it) rather than by object speed. We tested tracking of one, two, and three moving targets while the eyes remained fixed. Variation of the number of distracters and their speed revealed both speed limits and temporal frequency limits on tracking. The temporal frequency limit fell from 7 Hz with one target to 4 Hz with two targets and 2.6 Hz with three targets. The large size of this performance decrease implies that in the two-target condition participants would have done better by tracking only one of the two targets and ignoring the other. These effects are predicted by serial models involving a single tracking focus that must switch among the targets, sampling the position of only one target at a time. If parallel processing theories are to explain why dividing the tracking resource reduces temporal resolution so markedly, supplemental assumptions will be required.

  13. Iron absorption after introducing and discontinuation of iron and zinc supplementation in rats.

    PubMed

    Januszko, Olga; Madej, Dawid; Brzozowska, Anna; Kaluza, Joanna

    2016-05-01

    The aim of this study was to investigate the changes in iron apparent absorption (IAA%) during and after iron and zinc supplementation in rats. The study was conducted on 6-week old male Wistar rats in 3 stages: 4-week period of adaptation to the control (C) and iron deficient (D) diets (stage I); 4-week period of supplementation with 10-time more iron (CSFe, DSFe), zinc (CSZn, DSZn) or both iron and zinc (CSFeZn, DSFeZn) compared to C diet (stage II); 2-week of post-supplementation period (rats were fed the same diets as in the adaptation period, stage III). IAA% was measured in five consecutive days directly after introducing and discontinuation of iron and zinc supplementation as well as in the end of stage II (days: 22-24th) and stage III (days: 8-10th). Overall in the second day after introducing and in the fifth day after discontinuation of iron or iron and zinc supplementation, the IAA% had undergone to the level compatible with the values in the end of each stage. At the end of stage II, IAA% in CSFeZn (54.1 ± 2.7%) rats was not different from the IAA% in CSFe rats (53.9 ± 1.9%), but in DSFeZn group IAA% (49.4 ± 2.1%) was significantly lower than in DSFe (57.4 ± 2.3%) group. Moreover, IAA% after stage II and stage III in DSZn group was significantly lower (39.2 ± 2.8% and 38.6 ± 2.6%, respectively) than in group D (60.7 ± 1.9% and 54.3 ± 3.0%, respectively). In conclusion, zinc administered simultaneously with iron (Zn:Fe weight ratio=1:1) decreased IAA% in adult rats fed on iron deficient diet, but not in rats fed on control diet. IAA% reduction by zinc supplementation has been extended to 10 days after discontinuation of the treatment. Adaptation of the rats to high doses of iron or iron and zinc and also to the cessation of these treatments was relatively fast. However, IAA% was stabilized faster after introducing the supplementation than it's discontinuation.

  14. Perceptual discontinuities and categorization: Implications for speech perception

    NASA Astrophysics Data System (ADS)

    Holt, Lori L.; Lotto, Andrew J.; Diehl, Randy L.

    2003-04-01

    Behavioral experiments with infants, adults and nonhuman animals converge with neurophysiological findings to suggest that there is a discontinuity in auditory processing of stimulus components differing in onset time by about 20 ms. This discontinuity has been implicated as a basis for boundaries between speech categories distinguished by VOT. Here, we investigate how this discontinuity interacts with the learning of novel perceptual categories. Adult listeners were trained to categorize a nonspeech acoustic cue that mimics the temporal distinction of VOT. One group of listeners learned categories with a boundary coincident with the perceptual discontinuity. Another group learned categories defined such that the perceptual discontinuity fell within a category. Listeners in the latter group required significantly more experience to reach criterion categorization performance. The evidence of interactions between the perceptual discontinuity and the learned categories extended to generalization tests as well. It has been hypothesized that languages make use of perceptual discontinuities to promote perceptual distinctiveness among sounds within a language inventory. The present data suggest that these influences interact with category learning. As such, learnability may play a predictive role in selection of language sound inventories. Moreover, it may be possible to observe predictable learning effects in infant speech perception.

  15. Magnetic discontinuities in magnetohydrodynamic turbulence and in the solar wind.

    PubMed

    Zhdankin, Vladimir; Boldyrev, Stanislav; Mason, Joanne; Perez, Jean Carlos

    2012-04-27

    Recent measurements of solar wind turbulence report the presence of intermittent, exponentially distributed angular discontinuities in the magnetic field. In this Letter, we study whether such discontinuities can be produced by magnetohydrodynamic (MHD) turbulence. We detect the discontinuities by measuring the fluctuations of the magnetic field direction, Δθ, across fixed spatial increments Δx in direct numerical simulations of MHD turbulence with an imposed uniform guide field B(0). A large region of the probability density function (pdf) for Δθ is found to follow an exponential decay, proportional to exp(-Δθ/θ(*)), with characteristic angle θ(*)≈(14°)(b(rms)/B(0))(0.65) for a broad range of guide-field strengths. We find that discontinuities observed in the solar wind can be reproduced by MHD turbulence with reasonable ratios of b(rms)/B(0). We also observe an excess of small angular discontinuities when Δx becomes small, possibly indicating an increasing statistical significance of dissipation-scale structures. The structure of the pdf in this case closely resembles the two-population pdf seen in the solar wind. We thus propose that strong discontinuities are associated with inertial-range MHD turbulence, while weak discontinuities emerge from dissipation-range turbulence. In addition, we find that the structure functions of the magnetic field direction exhibit anomalous scaling exponents, which indicates the existence of intermittent structures.

  16. Outcomes of patients with chronic lymphocytic leukemia after discontinuing ibrutinib

    PubMed Central

    Jain, Preetesh; Keating, Michael; Wierda, William; Estrov, Zeev; Ferrajoli, Alessandra; Jain, Nitin; George, Binsah; James, Danelle; Kantarjian, Hagop; Burger, Jan

    2015-01-01

    Ibrutinib is a Bruton tyrosine kinase inhibitor approved for the treatment of patients with relapsed refractory chronic lymphocytic leukemia (RR-CLL). We describe the characteristics, causes of discontinuation, and outcomes in patients who discontinued treatment with ibrutinib. One hundred twenty-seven patients were enrolled in various clinical trials of ibrutinib, with or without rituximab, at our center. Thirty-three (26%) patients have discontinued ibrutinib to date. The majority of those patients had high-risk features: 94% with unmutated immunoglobulin heavy chain variable gene rearrangement, 58% with del(17p) by fluorescence in situ hybridization, and 54% with a complex karyotype. Causes of discontinuation were disease transformation (7), progressive CLL (7), stem cell transplantation (3), adverse events (11), serious adverse events/deaths (3), and miscellaneous reasons (2). Twenty five patients (76%) died after discontinuing ibrutinib; the median overall survival was 3.1 months after discontinuation. Most patients with RR-CLL who discontinued ibrutinib early were difficult to treat and had poor outcomes. PMID:25573991

  17. Design and performance of a 250 Hz alexandrite laser

    SciTech Connect

    Sam, R.C.; Yeh, J.J.; Leslie, K.R.; Rapoport, W.R.

    1988-06-01

    The design, analysis, and performance of a 250 Hz alexandrite laser are described. Built as the wavelength selective laser for a molecular laser isotope separation program, the laser has to satisfy specifications on its tuning band, linewidth, output energy, temporal behavior, and repetition rate required by the process. The key design feature is the use of a tandem rod oscillator with concave curvature on rod ends for thermal lensing compensation. A model was developed to project the stability range and beam quality relative to repetition rate. The performance results of a delivered system are presented and future developments are discussed.

  18. The 2.2 Hz oscillations in auroral electrons

    NASA Astrophysics Data System (ADS)

    Lepine, D. R.; Hall, D. S.; Bryant, D. A.; Johnstone, A. D.; Christiansen, P. J.; Gough, M. P.

    1980-06-01

    A Petrel rocket was launched from Kiruna on 25 January 1979 to compare electron intensities measured at auroral altitudes with related parameters measured at geostationary altitude by the satellite GEOS 2. A sequence of quasi-periodic oscillations in electron intensities were investigated, which appear to originate in the equatorial region, probably in the neighborhood of GEOS 2 was investigated. A similar frequency oscillation in the intensity of 500-Hz VLF emissions was observed at about the same time by the S300 wave experiment located on the satellite.

  19. 1-kHz-repetition-rate femtosecond Raman laser

    NASA Astrophysics Data System (ADS)

    Didenko, N. V.; Konyashchenko, A. V.; Kostryukov, P. V.; Losev, L. L.; Pazyuk, V. S.; Tenyakov, S. Yu

    2016-07-01

    A femtosecond Raman laser utilising compressed hydrogen is experimentally investigated under pumping by radiation from a 1-kHz-repetition-rate Ti : sapphire laser. In the regime of double-pulse pumping, the conditions are determined, which correspond to the minimal energy dispersion of Stokes pulses. The optical scheme is realised, which is capable of ensuring the long-term stability of the average power of the first Stokes component with a variation of less than 2%. The Stokes pulses are produced with a pulse duration of 60 fs and energy of 0.26 mJ at a conversion efficiency of 14%.

  20. Discontinuity of cortical gradients reflects sensory impairment

    PubMed Central

    Saadon-Grosman, Noam; Tal, Zohar; Itshayek, Eyal; Amedi, Amir; Arzy, Shahar

    2015-01-01

    Topographic maps and their continuity constitute a fundamental principle of brain organization. In the somatosensory system, whole-body sensory impairment may be reflected either in cortical signal reduction or disorganization of the somatotopic map, such as disturbed continuity. Here we investigated the role of continuity in pathological states. We studied whole-body cortical representations in response to continuous sensory stimulation under functional MRI (fMRI) in two unique patient populations—patients with cervical sensory Brown-Séquard syndrome (injury to one side of the spinal cord) and patients before and after surgical repair of cervical disk protrusion—enabling us to compare whole-body representations in the same study subjects. We quantified the spatial gradient of cortical activation and evaluated the divergence from a continuous pattern. Gradient continuity was found to be disturbed at the primary somatosensory cortex (S1) and the supplementary motor area (SMA), in both patient populations: contralateral to the disturbed body side in the Brown-Séquard group and before repair in the surgical group, which was further improved after intervention. Results corresponding to the nondisturbed body side and after surgical repair were comparable with control subjects. No difference was found in the fMRI signal power between the different conditions in the two groups, as well as with respect to control subjects. These results suggest that decreased sensation in our patients is related to gradient discontinuity rather than signal reduction. Gradient continuity may be crucial for somatotopic and other topographical organization, and its disruption may characterize pathological processing. PMID:26655739

  1. Discontinuity of cortical gradients reflects sensory impairment.

    PubMed

    Saadon-Grosman, Noam; Tal, Zohar; Itshayek, Eyal; Amedi, Amir; Arzy, Shahar

    2015-12-29

    Topographic maps and their continuity constitute a fundamental principle of brain organization. In the somatosensory system, whole-body sensory impairment may be reflected either in cortical signal reduction or disorganization of the somatotopic map, such as disturbed continuity. Here we investigated the role of continuity in pathological states. We studied whole-body cortical representations in response to continuous sensory stimulation under functional MRI (fMRI) in two unique patient populations-patients with cervical sensory Brown-Séquard syndrome (injury to one side of the spinal cord) and patients before and after surgical repair of cervical disk protrusion-enabling us to compare whole-body representations in the same study subjects. We quantified the spatial gradient of cortical activation and evaluated the divergence from a continuous pattern. Gradient continuity was found to be disturbed at the primary somatosensory cortex (S1) and the supplementary motor area (SMA), in both patient populations: contralateral to the disturbed body side in the Brown-Séquard group and before repair in the surgical group, which was further improved after intervention. Results corresponding to the nondisturbed body side and after surgical repair were comparable with control subjects. No difference was found in the fMRI signal power between the different conditions in the two groups, as well as with respect to control subjects. These results suggest that decreased sensation in our patients is related to gradient discontinuity rather than signal reduction. Gradient continuity may be crucial for somatotopic and other topographical organization, and its disruption may characterize pathological processing. PMID:26655739

  2. Imaging Resolution of 410-km and 660-km Discontinuities

    NASA Astrophysics Data System (ADS)

    Deng, Kai; Zhou, Ying

    2014-05-01

    Seismic discontinuities in the mantle transition zone at depths of about 410 and 660 km are associated with olivine phase transformations. The depths of the discontinuities provide important constraints on the thermal structure of the mid mantle. Teleseismic receiver functions as well as PP and SS precursors have been widely used in imaging topographic variations of the 410 and 660 discontinuities. Ray-theory based migration and stacking methods are often used to enhance signals of the converted and reflected waves, assuming that the effects of 3-D structure in wavespeed can be averaged out. In this study, we investigate the resolution of traditional methods in imaging the 410-km and 660-km discontinuity topography based on wave propagation simulations using the Spectral Element Method (SEM). We calculate synthetic seismograms in laterally heterogeneous wavespeed models with lateral variations in the 410-km and 660-km discontinuity depths. The SEM synthetics are processed following standard migration and stacking techniques to image the discontinuities. We show that 3-D wave speed structure beneath seismic stations can introduce significant artifacts in transition zone discontinuity topography. We also investigate finite-frequency effects of P-to-S converted waves as well as PP and SS precursors in imaging the discontinuities by varying the length scale of depth variations in the 410-km and 660-km discontinuities in SEM simulations, and show that wave front healing effects depend on the length scale of the depth variation as well as epicentral distances. Finally we compare receiver function delay times with calculations based on finite frequency sensitivity and show that wave front healing effects can be properly accounted for.

  3. Discontinuous Spectral Difference Method for Conservation Laws on Unstructured Grids

    NASA Technical Reports Server (NTRS)

    Liu, Yen; Vinokur, Marcel; Wang, Z. J.

    2004-01-01

    A new, high-order, conservative, and efficient method for conservation laws on unstructured grids is developed. The concept of discontinuous and high-order local representations to achieve conservation and high accuracy is utilized in a manner similar to the Discontinuous Galerkin (DG) and the Spectral Volume (SV) methods, but while these methods are based on the integrated forms of the equations, the new method is based on the differential form to attain a simpler formulation and higher efficiency. A discussion on the Discontinuous Spectral Difference (SD) Method, locations of the unknowns and flux points and numerical results are also presented.

  4. Discontinuous Galerkin computation of the Maxwell eigenvalues on simplicial meshes

    NASA Astrophysics Data System (ADS)

    Buffa, Annalisa; Houston, Paul; Perugia, Ilaria

    2007-07-01

    This paper is concerned with the discontinuous Galerkin approximation of the Maxwell eigenproblem. After reviewing the theory developed in [A. Buffa, I. Perugia, Discontinuous Galerkin approximation of the Maxwell eigenproblem, Technical Report 24-PV, IMATI-CNR, Pavia, Italy, 2005 ], we present a set of numerical experiments which both validate the theory, and provide further insight regarding the practical performance of discontinuous Galerkin methods, particularly in the case when non-conforming meshes, characterized by the presence of hanging nodes, are employed.

  5. Risk of discontinuation of Advanced Therapy Medicinal Products clinical trials

    PubMed Central

    Hanna, Eve; Rémuzat, Cecile; Auquier, Pascal; Toumi, Mondher

    2016-01-01

    Objective Advanced therapy medicinal products (ATMPs) constitute a class of innovative products that encompasses gene therapy, somatic cell therapy, and tissue-engineered products (TEP). There is an increased investment of commercial and non-commercial sponsors in this field and a growing number of ATMPs randomized clinical trials (RCT) and patients enrolled in such trials. RCT generate data to prove the efficacy of a new therapy, but the discontinuation of RCTs wastes scarce resources. Our objective is to identify the number and characteristics of discontinued ATMPs trials in order to evaluate the rate of discontinuation. Methods We searched for ATMPs trials conducted between 1999 to June 2015 using three databases, which are Clinicaltrials.gov, the International Clinical Trials Registry Platform (ICTRP), and the EU Drug Regulating Authorities Clinical Trials (EudraCT). We selected the ATMPs trials after elimination of the duplicates. We identified the disease areas and the sponsors as commercial or non-commercial organizations. We classified ATMPs by type and trial status, that is, ongoing, completed, terminated, discontinued, and prematurely ended. Then, we calculated the rate of discontinuation. Results Between 1999 and June 2015, 143 withdrawn, terminated, or prematurely ended ATMPs clinical trials were identified. Between 1999 and June 2013, 474 ongoing and completed clinical trials were identified. Therefore, the rate of discontinuation of ATMPs trials is 23.18%, similar to that for non-ATMPs drugs in development. The probability of discontinuation is, respectively, 27.35, 16.28, and 16.34% for cell therapies, gene therapies, and TEP. The highest discontinuation rate is for oncology (43%), followed by cardiology (19.2%). It is almost the same for commercial and non-commercial sponsors; therefore, the discontinuation reason may not be financially driven. Conclusion No failure risk rate per development phase is available for ATMPs. The discontinuation rate may

  6. Accountability Accentuates Interindividual-Intergroup Discontinuity by Enforcing Parochialism

    PubMed Central

    Wildschut, Tim; van Horen, Femke; Hart, Claire

    2015-01-01

    Interindividual-intergroup discontinuity is the tendency for relations between groups to be more competitive than relations between individuals. We examined whether the discontinuity effect arises in part because group members experience normative pressure to favor the ingroup (parochialism). Building on the notion that accountability enhances normative pressure, we hypothesized that the discontinuity effect would be larger when accountability is present (compared to absent). A prisoner’s dilemma game experiment supported this prediction. Specifically, intergroup (compared to interindividual) interaction activated an injunctive ingroup-favoring norm, and accountability enhanced the influence of this norm on competitive behavior. PMID:26635691

  7. Coupling impedances of small discontinuities: A general approach

    NASA Astrophysics Data System (ADS)

    Kurennoy, Sergey S.; Gluckstern, Robert L.; Stupakov, Gennady V.

    1995-10-01

    A general theory of the beam interaction with small discontinuities of the vacuum chamber of an accelerator is developed taking into account the reaction of radiated waves back on the discontinuity. The reactive impedance calculated earlier is reproduced as the first order and the resistive one as the second order of a perturbation theory based on this general approach. The theory also gives, in an easy and natural way, the analytical results for the frequencies and coupling impedances of the trapped modes due to small discontinuities on the vacuum chamber of a general cross section. Formulas for two important particular cases-a circular and a rectangular chamber-are presented.

  8. Slip-stacking Dynamics and the 20 Hz Booster

    SciTech Connect

    Eldred, Jeffery; Zwaska, Robert

    2015-03-01

    Slip-stacking is an accumulation technique used at Fermilab since 2004 which nearly doubles the proton intensity. The Proton Improvement Plan II intensity upgrades require a reduction in slip-stacking losses by approximately a factor of 2. We study the single-particle dynamics that determine the stability of slip-stacking particles. We introduce universal area factors to calculate the available phase space area for any set of beam parameters without individual simulation. We show the particle loss as a function of time. We calculate the injection efficiency as a function of longitudinal emittance and aspect-ratio. We demonstrate that the losses from RF single particle dynamics can be reduced by a factor of 4-10 (depending on beam parameters) by upgrading the Fermilab Booster from a 15-Hz cycle-rate to a 20-Hz cycle-rate. We recommend a change in injection scheme to eliminate the need for a greater momentum aperture in the Fermilab Recycler.

  9. Endocrinological effects of strong 60-Hz electric fields on rats

    SciTech Connect

    Free, M.J.; Kaune, W.T.; Phillips, R.D.; Cheng, H.C.

    1981-01-01

    Adult male rats were exposed or sham-exposed to 60-Hz electric fields without spark discharges, ozone, or significant levels or other secondary variables. No effects were discharges, ozone, or significant levels of other secondary variables. No effects were observed on body weights or plasma hormone levels after 30 days of exposure at an effective field strength of 68 kV/m. After 120 days of exposure (effective field strength = 64 kV/m), effects were inconsistent, with signficant reductions in body weight and plasma levels of follicle-stimulating hormone and corticosterone occurring in one replicate experiment but not in the other. Plasma testosterone levels were significantly reduced after 120 days of exposure in one experiment, with a similar but not statistically significant reduction in a replicate experiment. Weanling rats, exposed or sham-exposed in electric fields with an effective field strength of 80 kV/m from 20 to 56 days of age, exhibited identical or closely similar growth trends in body and organ weights. Hormone levels in exposed and sham-exposed groups were also similar. However, there was an apparent phase shift between the two groups in the cyclic variations of concentrations of hormones at different stages of development, particularly with respect to follicle-stimulating hormone and corticosterone. We concluded that 60-Hz electric fields may bring about subtle changes in the endocrine system of rats, and that these changes may be related to alterations in episodic rhythms.

  10. On cell entropy inequality for discontinuous Galerkin methods

    NASA Technical Reports Server (NTRS)

    Jiang, Guangshan; Shu, Chi-Wang

    1993-01-01

    We prove a cell entropy inequality for a class of high order discontinuous Galerkin finite element methods approximating conservation laws, which implies convergence for the one dimensional scalar convex case.

  11. PML-IRIS during Fingolimod Diagnosed after Natalizumab Discontinuation

    PubMed Central

    Killestein, J.; Vennegoor, A.; van Golde, A. E. L.; Bourez, R. L. J. H.; Wijlens, M. L. B.; Wattjes, M. P.

    2014-01-01

    Background. Natalizumab treatment is frequently discontinued and replaced by alternative medication in multiple sclerosis (MS) patients having a high risk of progressive multifocal leukoencephalopathy (PML). Case Presentation. We report a PML case that was missed on magnetic resonance imaging (MRI) at the time Natalizumab treatment was discontinued. The patient subsequently developed a PML-immune reconstitution inflammatory syndrome after the initiation of Fingolimod treatment, suggesting that immune reconstitution may occur even during Fingolimod induced lymphopenia. Conclusion. This report highlights the need for strict drug surveillance using MRI of Natalizumab-associated MS patients at the time of drug discontinuation and beyond. This is important with respect to pharmacovigilance purposes not only for Natalizumab, but also for alternative drugs used after Natalizumab discontinuation. PMID:25506447

  12. Robust state estimation for neural networks with discontinuous activations.

    PubMed

    Liu, Xiaoyang; Cao, Jinde

    2010-12-01

    Discontinuous dynamical systems, particularly neural networks with discontinuous activation functions, arise in a number of applications and have received considerable research attention in recent years. In this paper, the robust state estimation problem is investigated for uncertain neural networks with discontinuous activations and time-varying delays, where the neuron-dependent nonlinear disturbance on the network outputs are only assumed to satisfy the local Lipschitz condition. Based on the theory of differential inclusions and nonsmooth analysis, several criteria are presented to guarantee the existence of the desired robust state estimator for the discontinuous neural networks. It is shown that the design of the state estimator for such networks can be achieved by solving some linear matrix inequalities, which are dependent on the size of the time derivative of the time-varying delays. Finally, numerical examples are given to illustrate the theoretical results.

  13. Propagating plasma discontinuity in a tube immersed in distilled water

    NASA Astrophysics Data System (ADS)

    Song, Jian; Tang, Jingfeng; Wei, Liqiu; Zhang, Nan; Wang, Youyin; Yu, Daren

    2016-04-01

    In a dielectric tube partially surrounded by distilled water, a propagating discontinuity is observed in a cold argon plasma jet at atmospheric pressure in both the laminar and turbulent flow regimes. Through electrical and optical diagnostics, the mechanism of formation for this phenomenon is investigated. Results show that the strong polarization of the distilled water, the constraint from the electric field (or a sufficiently high electric field), and the transport of the active species are in combination responsible for the propagating plasma discontinuity. Indeed, smaller surface areas of the tube surrounded by distilled water, shorter distances between the distilled water and the ground electrodes, as well as larger gas flow rates can together make the discontinuous discharge channel appear more readily. In particular, when the flow switches from laminar to turbulent, the plasma behavior of the discontinuity no longer depends on the gas flow rate. This is mostly attributed to the extreme instability of turbulence which further suppresses the transport of active species.

  14. Discontinuation of Antidepressant Medication Among Latinos in the US

    PubMed Central

    Hodgkin, Dominic; Volpe-Vartanian, Joanna; Alegría, Margarita

    2009-01-01

    Despite recent growth in the variety of antidepressant medications available, many patients discontinue medication prematurely, for reasons such as nonresponse, side effects, stigma and miscommunication. Some analysts have suggested that Latinos may have higher antidepressant discontinuation rates than other US residents. This paper examines Latino antidepressant discontinuation, using data from a national probability survey of Latinos in the US. In this sample, 8% of Latinos had taken an antidepressant in the preceding 12 months. Among those users, 33.3% had discontinued taking antidepressants at the time of interview, and 18.9% had done so without prior input from their physician. Even controlling for clinical and other variables, patients who reported good or excellent English proficiency were less likely to stop at all. Patients were also less likely to stop if they were older, married, had public or private insurance, or had made eight or more visits to a nonmedical therapist. PMID:17570068

  15. 47 CFR 5.81 - Discontinuance of station operation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Discontinuance of station operation. 5.81 Section 5.81 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL EXPERIMENTAL RADIO SERVICE (OTHER... Commission's Office of Engineering and Technology for cancellation....

  16. Discontinuities, cross-scale patterns, and the organization of ecosystems

    USGS Publications Warehouse

    Nash, Kirsty L.; Allen, Craig R.; Angeler, David G.; Barichievy, Chris; Eason, Tarsha; Garmestani, Ahjond S.; Graham, Nicholas A.J.; Granholm, Dean; Knutson, Melinda; Nelson, R. John; Nystrom, Magnus; Stow, Craig A.; Sandstrom, Shana M.

    2014-01-01

    Ecological structures and processes occur at specific spatiotemporal scales, and interactions that occur across multiple scales mediate scale-specific (e.g., individual, community, local, or regional) responses to disturbance. Despite the importance of scale, explicitly incorporating a multi-scale perspective into research and management actions remains a challenge. The discontinuity hypothesis provides a fertile avenue for addressing this problem by linking measureable proxies to inherent scales of structure within ecosystems. Here we outline the conceptual framework underlying discontinuities and review the evidence supporting the discontinuity hypothesis in ecological systems. Next we explore the utility of this approach for understanding cross-scale patterns and the organization of ecosystems by describing recent advances for examining nonlinear responses to disturbance and phenomena such as extinctions, invasions, and resilience. To stimulate new research, we present methods for performing discontinuity analysis, detail outstanding knowledge gaps, and discuss potential approaches for addressing these gaps.

  17. 7 CFR 160.55 - Voluntary discontinuance of licensed inspection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... licensed inspectors for making official inspections, gradings, and certifications of naval stores, shall give not less than 30 days notice in writing to the Administrator of the intention to discontinue...

  18. Calculation of Accurate Hexagonal Discontinuity Factors for PARCS

    SciTech Connect

    Pounders. J., Bandini, B. R. , Xu, Y, and Downar, T. J.

    2007-11-01

    In this study we derive a methodology for calculating discontinuity factors consistent with the Triangle-based Polynomial Expansion Nodal (TPEN) method implemented in PARCS for hexagonal reactor geometries. The accuracy of coarse-mesh nodal methods is greatly enhanced by permitting flux discontinuities at node boundaries, but the practice of calculating discontinuity factors from infinite-medium (zero-current) single bundle calculations may not be sufficiently accurate for more challenging problems in which there is a large amount of internodal neutron streaming. The authors therefore derive a TPEN-based method for calculating discontinuity factors that are exact with respect to generalized equivalence theory. The method is validated by reproducing the reference solution for a small hexagonal core.

  19. Method and device for detection of surface discontinuities or defects

    NASA Technical Reports Server (NTRS)

    Leger, L. J. (Inventor)

    1974-01-01

    Surface discontinuities of defects such as cracks and orifices are detected by applying a penetrating fluid, preferably a liquid, to a test surface so as to cause the liquid to penetrate any minute cracks or opening in the surface, removing the excess liquid from the surface, and leaving a residual in the discontinuities, cavities, or in the subsurface materials. A sheet of porous material impregnated with a sensitizing medium which will react with vapors of the residual liquid to form a visible pattern is applied to the test surface. The residual liquid trapped in the discontinuities, cavities, or subsurface material is vaporized, and, as the vapors contact the sensitizing medium on the sheet, a pattern corresponding to the discontinuity is formed on the sheet material and the penetrant completely removed from the sample.

  20. Toward a comprehensive understanding of transition zone seismic discontinuities: A new constraint near the stagnant slab region beneath China

    NASA Astrophysics Data System (ADS)

    Song, T. R. A.; Shen, X.; Stixrude, L. P.; Lithgow-Bertelloni, C. R.

    2015-12-01

    Plate tectonics and subduction operating over much of the Earth's history can induce mantle mixing, chemical heterogeneities and recycle volatiles into the mantle. Some slabs are penetrating into the deep lower mantle, but others are stagnated near the transition zone (TZ). Presumably, the thermochemical state of the TZ is a consequence of delicate balance and feedback between the short-term and long-term mixing. Near the stagnant slab, what's the thermochemical state of the TZ? what's the degree of hydration in the TZ? TZ seismic discontinuities hold the key to resolve the mystery of mass and heat transport in the Earth's mantle as well as the composition of the Earth's interior. But deciphering discontinuity properties are not trivial. Data were typically limited to either mantle triplications, converted waves (P-to-S or S-to-P) or mantle reflections (e.g. SS precursors, ScS reverberations). These observations place constraints on the velocity gradient near the discontinuity as well as discontinuity reflectivity, but hardly offer independent information on the density jump or/and density gradient. In few cases where multiple datasets are jointly analysed to resolve the density jump, the region of sensitivity (or the fresnel zone) of different dataset does not necessarily coincide. Finally, the use of short period (~1 Hz) data (e.g., P'P' precursors) or long period (~> 0.1 Hz) data (e.g., SS precursors) does not allow us to simultaneously address the transition width and the gradient near the discontinuity. We advocate a simple and effective strategy. Specifically, we involve broadband direct converted waves (e.g., P410s, P660s) and the topside reflections (the multiples, e.g., PpP410s, PpP660s) in the context of P wave receiver function technique. Such a tactic not only minimizes tradeoffs between velocity and density jumps, but allows self-consistent estimates of the shear velocity jump, the density jump, the transition width and the velocity/density gradient

  1. The global distribution of natural and man-made ionospheric electric fields at 200 kHz and 540 kHz as observed by Ogo 6

    NASA Technical Reports Server (NTRS)

    Laaspere, T.; Semprebon, L. C.

    1974-01-01

    An experiment on the polar-orbiting Ogo 6 spacecraft yielded real-time analog data in several broadband channels and essentially continuous tape-recorded data from two narrow-band (200-Hz) receivers operating at 200 and 540 kHz. The results show that the worldwide distributions of signals at 200 and 540 kHz falls into a number of different categories: (1) naturally generated broadband (auroral) hiss at polar latitudes with typical 200-kHz intensities of around 0.1 microvolt per meter per Hz to the 1/2 power, maximum intensities of up to several microvolt per meter per Hz to the 1/2 power, and generally lower intensities at 540 kHz; (2) nighttime midlatitude enhancements of a few microvolts per meter, which probably result either from a superposition of signals from a number of 200- and 540-kHz stations or from interference from intense signals of much higher frequencies; (3) well-defined signal peaks associated with individual ground stations operating at 200 kHz; (4) striking signal enhancements in the conjugate region of a low-latitude 200-kHz station (Ashkhabad), suggesting propagation in the whistler mode to the opposite hemisphere; and (5) occasional signal enhancements at the magnetic equator.

  2. 41 CFR 109-39.105 - Discontinuance or curtailment of service.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... AVIATION, TRANSPORTATION, AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and Discontinuance of Interagency Fleet Management Systems § 109-39.105 Discontinuance...

  3. Heat exchanger containing a component capable of discontinuous movement

    DOEpatents

    Wilson, D.G.

    1993-11-09

    Regenerative heat exchangers are described for transferring heat between hot and cold fluids. The heat exchangers have seal-leakage rates significantly less than those of conventional regenerative heat exchangers because the matrix is discontinuously moved and is releasably sealed while in a stationary position. Both rotary and modular heat exchangers are described. Also described are methods for transferring heat between a hot and cold fluid using the discontinuous movement of matrices. 11 figures.

  4. Determining the Locations and Discontinuities in the Derivatives of Functions

    SciTech Connect

    Archibald, Richard K; Gelb, Anne; Yoon, Jungho

    2007-01-01

    We introduce a method for detecting discontinuities in piecewise smooth functions and in their derivatives. The method is constructed from a local stencil of grid point values and is based on a polynomial annihilation technique. By varying the order of the method and the arrangement of the corresponding stencils, the jump discontinuities of a function and its derivatives can be identified with high order accuracy. The method is efficient and robust and can be applied to non-uniform distributions in one dimension.

  5. Shallow Mantle Discontinuities Beneath the North Anatolian Fault

    NASA Astrophysics Data System (ADS)

    Friedman, D. P.; Fischer, K. M.; Hopper, E.

    2015-12-01

    The goal of this study is to better understand deformation in the mantle lithosphere beneath continental strike-slip plate boundaries through Sp receiver function analysis of mantle discontinuities beneath the North Anatolian Fault (NAF). This fault zone marks the boundary between the Anatolian and Eurasian plates. Sp receiver functions were calculated using waveforms filtered with a variety of bandpasses, and 33 s to 4 s was found to produce coherent images while reducing interference between phases from the Moho and shallow mantle discontinuities. Using common conversion point stacking, we calculated 3D images of scattering beneath the region for two different cases: migration with the S-wave and P-wave velocities from the waveform tomography model of Fichtner et al. (2013) and with the AK135 velocity model. In both cases, a clear Moho is observed and Moho depth does not systematically vary between sides of the NAF. In contrast, shallow mantle discontinuities show pronounced changes in depth that correlate with strong lateral variations in mantle velocity observed in the Fichtner et al. tomography model, and some of these discontinuity depth variations occur within 50 km horizontally of the surface expression of the NAF. Where the tomography contains a clear high velocity lithospheric mantle layer, the Sp stack contains a negative velocity gradient at depths comparable to the base of the high velocity layer that can be interpreted as the seismological LAB. Where the tomography shows low mantle velocities that persist to the crust, a feature that may represent either anomalously low velocity lithosphere or upwelling asthenosphere beneath thin lithosphere, mantle discontinuities differ significantly from surrounding regions. Mantle discontinuity depth variations beneath the NAF also occur when the data are migrated with the AK135 model. Hence, the presence of the discontinuity depth variations is not an artifact of the assumed velocity model, although depths differ

  6. Heat exchanger containing a component capable of discontinuous movement

    DOEpatents

    Wilson, David G.

    1993-01-01

    Regenerative heat exchangers are described for transferring heat between hot and cold fluids. The heat exchangers have seal-leakage rates significantly less than those of conventional regenerative heat exchangers because the matrix is discontinuously moved and is releasably sealed while in a stationary position. Both rotary and modular heat exchangers are described. Also described are methods for transferring heat between a hot and cold fluid using the discontinuous movement of matrices.

  7. Heat exchanger containing a component capable of discontinuous movement

    DOEpatents

    Wilson, David Gordon

    2001-04-17

    Regenerative heat exchangers are described for transferring heat between hot and cold fluids. The heat exchangers have seal-leakage rates significantly less than those of conventional regenerative heat exchangers because the matrix is discontinuously moved and is releasably sealed while in a stationary position. Both rotary and modular heat exchangers are described. Also described are methods for transferring heat between a hot and cold fluid using the discontinuous movement of matrices.

  8. Heat exchanger containing a component capable of discontinuous movement

    DOEpatents

    Wilson, David Gordon

    2002-01-01

    Regenerative heat exchangers are described for transferring heat between hot and cold fluids. The heat exchangers have seal-leakage rates significantly less than those of conventional regenerative heat exchangers because the matrix is discontinuously moved and is releasably sealed while in a stationary position. Both rotary and modular heat exchangers are described. Also described are methods for transferring heat between a hot and cold fluid using the discontinuous movement of matrices.

  9. Implications of bevacizumab discontinuation in adults with recurrent glioblastoma

    PubMed Central

    Anderson, Mark D.; Hamza, Mohamed A.; Hess, Kenneth R.; Puduvalli, Vinay K.

    2014-01-01

    Background Patients with recurrent glioblastoma benefiting from bevacizumab are often treated indefinitely due to concerns regarding rebound tumor recurrence upon discontinuation. However, treatment is discontinued for reasons other than disease progression in a subset of these patients, the characteristics and outcomes of which are poorly defined. Methods Of 342 adults with recurrent glioblastoma in our database treated with bevacizumab, 82 received treatment for ≥6 months; of these, bevacizumab was discontinued for reasons other than tumor progression in 18 patients (Bev-D) and for disease progression in the remainder (Bev-S). The impact of discontinuation on outcome was assessed with discontinuation as a time-dependent covariate in a Cox hazards model for progression-free survival. Results There was no difference in hazard rates for progression between Bev-D and Bev-S groups; the adjusted hazard ratio for progression using discontinuation as a time-dependent covariate was 0.91 (95% CI:0.47, 1.78). The median PFS after bevacizumab-discontinuation was 27 weeks (95% CI:15-NR). At progression, a higher proportion of Bev-D patients had local progression compared with the Bev-S patients. Salvage therapy in Bev-D patients yielded a PFS-26 weeks of 47% (95% CI:23%–94%) with a median PFS of 23 weeks (95% CI:12-NR), vs. 5% (95% CI: 1%–21%) and 9 weeks (95% CI: 6–11) in Bev-S patients (HR:0.3;CI, 0.1–0.6) (P = .0007). Conclusions Bevacizumab discontinuation unrelated to disease progression does not appear to cause rebound recurrence or worsen PFS in patients who benefit from bevacizumab. Additionally, Bev-D patients had an improved response to salvage therapy, findings which provide a strong basis for a prospective study. PMID:24596117

  10. Unplanned discontinuation of tyrosine kinase inhibitors in chronic myeloid leukemia

    PubMed Central

    TSUTSUMI, YUTAKA; ITO, SHINICHI; OHIGASHI, HIROYUKI; SHIRATORI, SOUICHI; TESHIMA, TAKANORI

    2016-01-01

    This study was conducted to investigate the outcomes of patients with chronic myeloid leukemia (CML) who discontinued tyrosine kinase inhibitor (TKI) treatment. A single-center retrospective analysis was performed, including 46 chronic-phase (CP) CML patients who achieved complete molecular response (CMR) with TKIs. TKI treatment was discontinued in 13 patients based on their requests. The BCR-ABL transcript levels were monitored in the peripheral blood by quantitative polymerase chain reaction analysis following treatment discontinuation. Of the 13 patients who discontinued TKI treatment, 7 remained in CMR, with a median follow-up of 26 months (range, 10–60 months). The remaining 6 patients lost CMR following TKI discontinuation; 2 of these patients achieved a second CMR following re-administration of TKIs, 2 patients spontaneously achieved CMR and 2 remained in complete hematological response (CHR) without TKI treatment with a median follow-up of 29.5 months (range, 10–52 months). In conclusion, the survival of patients who lost CMR following TKI discontinuation may not be affected, even without re-administration of TKIs. Vigilant observation is recommended for such patients. The limitations of this study included the small patient sample, retrospective design and patient heterogeneity. Therefore, the results must be interpreted with caution. PMID:26870364

  11. Minimizers with discontinuous velocities for the electromagnetic variational method

    SciTech Connect

    De Luca, Jayme

    2010-08-15

    The electromagnetic two-body problem has neutral differential delay equations of motion that, for generic boundary data, can have solutions with discontinuous derivatives. If one wants to use these neutral differential delay equations with arbitrary boundary data, solutions with discontinuous derivatives must be expected and allowed. Surprisingly, Wheeler-Feynman electrodynamics has a boundary value variational method for which minimizer trajectories with discontinuous derivatives are also expected, as we show here. The variational method defines continuous trajectories with piecewise defined velocities and accelerations, and electromagnetic fields defined by the Euler-Lagrange equations on trajectory points. Here we use the piecewise defined minimizers with the Lienard-Wierchert formulas to define generalized electromagnetic fields almost everywhere (but on sets of points of zero measure where the advanced/retarded velocities and/or accelerations are discontinuous). Along with this generalization we formulate the generalized absorber hypothesis that the far fields vanish asymptotically almost everywhere and show that localized orbits with far fields vanishing almost everywhere must have discontinuous velocities on sewing chains of breaking points. We give the general solution for localized orbits with vanishing far fields by solving a (linear) neutral differential delay equation for these far fields. We discuss the physics of orbits with discontinuous derivatives stressing the differences to the variational methods of classical mechanics and the existence of a spinorial four-current associated with the generalized variational electrodynamics.

  12. Bifurcation and chaotic threshold of Duffing system with jump discontinuities

    NASA Astrophysics Data System (ADS)

    Tian, Ruilan; Zhou, Yufeng; Wang, Qiubao; Zhang, Lili

    2016-01-01

    Like for the smooth system, it is important to determine a criteria for bifurcation of the non-smooth system with jump discontinuities. Previously, the criteria have been constructed in some non-smooth systems with jump discontinuities which are the endpoints of interval. The research on bifurcation for non-smooth system with jump discontinuities, which are the interior points of interval, seems to be a new area. We construct the Duffing system with jump discontinuities in open interval. Bifurcation diagram of the unperturbed system is detected and Hamilton phase diagrams are simulated using Matlab. The jump discontinuities for the non-smooth Homoclinic orbit lead to a barrier for conventional nonlinear techniques to obtain the criteria for chaotic motion. Traditionally, these non-smooth factors were considered term by term. We will give a reasonable compromise based on all of characteristics of the non-smooth homoclinic orbits with the jump discontinuities. The extended Melnikov function is explicitly detected to judge the stable and unstable manifolds whether intersect transversally at any position of trajectory under the perturbation of damping and external forcing. It is worthwhile noting that the result reveals the effects of the non-smooth restoring force on the behaviors of nonlinear dynamical systems. The efficiency of the theoretical results is verified by the phase portraits, Poincaré surface of section, Largest Lyapnnov exponents diagram and bifurcation diagram.

  13. Hyperspherical Sparse Approximation Techniques for High-Dimensional Discontinuity Detection

    DOE PAGES

    Zhang, Guannan; Webster, Clayton G.; Gunzburger, Max; Burkardt, John

    2016-08-04

    This work proposes a hyperspherical sparse approximation framework for detecting jump discontinuities in functions in high-dimensional spaces. The need for a novel approach results from the theoretical and computational inefficiencies of well-known approaches, such as adaptive sparse grids, for discontinuity detection. Our approach constructs the hyperspherical coordinate representation of the discontinuity surface of a function. Then sparse approximations of the transformed function are built in the hyperspherical coordinate system, with values at each point estimated by solving a one-dimensional discontinuity detection problem. Due to the smoothness of the hypersurface, the new technique can identify jump discontinuities with significantly reduced computationalmore » cost, compared to existing methods. Several approaches are used to approximate the transformed discontinuity surface in the hyperspherical system, including adaptive sparse grid and radial basis function interpolation, discrete least squares projection, and compressed sensing approximation. Moreover, hierarchical acceleration techniques are also incorporated to further reduce the overall complexity. In conclusion, rigorous complexity analyses of the new methods are provided, as are several numerical examples that illustrate the effectiveness of our approach.« less

  14. The analysis of plane discontinuities in offset cylindrical waveguides.

    PubMed

    Homentcovschi, Dorel; Miles, Ronald N

    2015-06-01

    This paper applies the re-expansion method for analyzing the effects on the sound field due to planar discontinuities at the junction of two offset circular acoustic waveguides. The normal modes in the two waveguides are expanded at the junction plane into a system of functions accounting for velocity singularities at the corner points. As the new expansion has a high convergence order, only a few terms have to be considered for obtaining the solution of most practical problems. This paper gives the equivalent impedance accounting for nonplanar waves into a plane-wave analysis. The last section of the paper applies the re-expansion technique to the case of two offset pipes (step discontinuity) and to that of an offset aperture in a cylindrical pipe (diaphragm-type discontinuity). The plots of the discontinuity inductance, characterized by Karal's factor, are quite similar but the values in the second case are 1.5-2 times larger, showing that the diaphragm-type discontinuity excites much more nonplanar evanescent modes than the step discontinuity.

  15. Global Observations of Mantle Discontinuities Using SS and PP Precursors

    NASA Astrophysics Data System (ADS)

    Deuss, Arwen

    2009-10-01

    SS and PP precursors are currently the only body wave data types that have significant coverage in both oceanic and continental regions to study the existence and characteristics of mantle discontinuities on a global scale. Here, the techniques used by global seismologists to observe SS and PP precursors are reviewed. Seismograms, aligned on SS or PP, are stacked using normal move out (NMO) techniques to obtain common depth point gathers. Bootstrap methods are employed to determine 95% confidence levels of the stacks and robustness of the observations. With these relatively simple techniques, a range of discontinuities has been found in the mantle up to 1,200 km depth. The stacks are dominated by the transition zone discontinuities at 410, 520 and 660 km depth, but additional discontinuities at 220, 300-350, 800-900 and 1,100-1,200 km depth are also seen in certain regions. An overview is given of the most recent observational results with a discussion of their mineral physical interpretation and geodynamical significance. Both seismology and mineral physics agree on the level of complexity at the transition discontinuities: a simple 410, a more complicated 520 and a highly complicated 660-km discontinuity are consistently found in both disciplines.

  16. Trapped modes in waveguides with many small discontinuities

    NASA Astrophysics Data System (ADS)

    Kurennoy, Sergey S.

    1995-03-01

    It has been demonstrated recently [G. V. Stupakov and S. S. Kurennoy, Phys. Rev. E 49, 794 (1994)] that a single small discontinuity (such as an enlargement or a hole) on a smooth waveguide can result in the appearance of trapped electromagnetic modes with frequencies slightly below the waveguide cutoff frequencies. The present paper studies a similar phenomenon for a waveguide with many small discontinuities, which is a good model for the vacuum chamber of large accelerators. Frequencies of trapped modes and their contributions to the coupling impedance are calculated. The frequencies for the cases of a few discontinuities or a periodic structure coincide well with those from numerical simulations. The trapped modes produce sharp resonance peaks of the coupling impedance near the cutoff frequencies. The magnitude of these peaks, as well as the existence itself of a trapped mode, strongly depends on the distribution of discontinuities, or on the distance between them if a regular array is considered. The impedance in the extreme case can be as large as N3 times that for a single discontinuity, where N is the number of discontinuities.

  17. 100 kHz Mueller polarimeter in reflection configuration.

    PubMed

    Le Gratiet, Aymeric; Rivet, Sylvain; Dubreuil, Matthieu; Le Grand, Yann

    2015-02-15

    A new setup is proposed to perform high-speed Mueller polarimetry by spectral coding of polarization in a reflection configuration. The system uses a swept laser source and a photodiode, which results in a simple optical setup that allows measurement of Mueller matrices at 100 kHz repetition rate. A special focus is made on the influence of the cube beam splitter polarimetric response, which is essential to measurements in a reflection configuration. The instrument is first validated on reference samples for single-point measurements, and the effect of a proper system calibration is also demonstrated on polarimetric images. The device is intended to be implemented within a laser scanning microscope to perform multimodal imaging (confocal/multiphoton and Mueller polarimetry). PMID:25680171

  18. Influence of 60-Hz magnetic fields on sea urchin development

    SciTech Connect

    Zimmerman, S.; Zimmerman, A.M.; Winters, W.D.; Cameron, I.L. )

    1990-01-01

    Continuous exposure of sea urchin (Strongylocentrotus purpuratus) embryos at 18 degrees C to a cyclic 60-Hz magnetic field at 0.1 mT rms beginning 4 min after insemination caused a significant developmental delay during the subsequent 23 hours. No delay in development was recorded for periods up to 18 hours after fertilization. At 18 h, most embryos were in the mesenchyme blastula stage. At 23 h, most control embryos were in mid-gastrula whereas most magnetic-field-exposed embryos were in the early gastrula stage. Thus an estimated 1-h delay occurred between these developmental stages. The results are discussed in terms of possible magnetic-field modification of transcription as well as interference with cell migration during gastrulation. The present study extends and supports the growing body of information about potential effects of exposures to extremely-low-frequency (ELF) magnetic fields on developing organisms.

  19. Investigation on Two-Stage 300 HZ Pulse Tube Cryocooler

    NASA Astrophysics Data System (ADS)

    Cai, H. K.; Yang, L. W.; Hong, G. T.; Luo, E. C.; Zhou, Y.

    2010-04-01

    In the past few years, ultra-high frequency pulse tube cryocoolers are becoming a research hotspot for their portability and compactness in aerospace and aviation applications. For preliminary research, a two-stage pulse tube cryocooler working at 300 Hz driven by a thermoacoustic engine is established to investigate the problems due to ultra high frequency, and several results have been derived in our early reports. In order to study the effect of thermal penetration depth, this paper presents the cooler adopting copper mesh as the regenerator, and comparison with stainless steel mesh is given. In addition, the influence of inertance tube on the lowest possible cooler temperature is also tested. Finally, we discuss the improvement for getting a lower temperature.

  20. EV drivetrain inverter with V/HZ optimization

    DOEpatents

    Gritter, David J.; O'Neil, Walter K.

    1986-01-01

    An inverter (34) which provides power to an A.C. machine (28) is controlled by a circuit (36) employing PWM control strategy whereby A.C. power is supplied to the machine at a preselectable frequency and preselectable voltage. This is accomplished by the technique of waveform notching in which the shapes of the notches are varied to determine the average energy content of the overall waveform. Through this arrangement, the operational efficiency of the A.C. machine is optimized. The control circuit includes a micro-computer which calculates optimized machine control data signals from various parametric inputs and during steady state load conditions, seeks a best V/HZ ratio to minimize battery current drawn (system losses) from a D.C. power source (32). In the preferred embodiment, the present invention is incorporated within an electric vehicle (10) employing a 144 VDC battery pack and a three-phase induction motor (18).

  1. Epilepsy provoked by television and video games: safety of 100-Hz screens.

    PubMed

    Ricci, S; Vigevano, F; Manfredi, M; Kasteleijn-Nolst Trenité, D G

    1998-03-01

    Television (TV) and video games (VG) can provoke seizures in patients with photosensitive epilepsies. Flicker frequency is the most important factor in screen activation. We tested conventional 50-Hz versus 100-Hz monitors during TV viewing and VG playing in 30 photosensitive subjects, 23 of whom had a history of TV or VG seizures or both. Fifteen subjects' discharges were activated by 50-Hz TV; 17 by 50-Hz VG; and one by a 100-Hz screen. Thus, 100-Hz screens protect against screen activation. PMID:9521278

  2. Epilepsy provoked by television and video games: safety of 100-Hz screens.

    PubMed

    Ricci, S; Vigevano, F; Manfredi, M; Kasteleijn-Nolst Trenité, D G

    1998-03-01

    Television (TV) and video games (VG) can provoke seizures in patients with photosensitive epilepsies. Flicker frequency is the most important factor in screen activation. We tested conventional 50-Hz versus 100-Hz monitors during TV viewing and VG playing in 30 photosensitive subjects, 23 of whom had a history of TV or VG seizures or both. Fifteen subjects' discharges were activated by 50-Hz TV; 17 by 50-Hz VG; and one by a 100-Hz screen. Thus, 100-Hz screens protect against screen activation.

  3. PET imaging of the 40 Hz auditory steady state response.

    PubMed

    Reyes, Samuel A; Salvi, Richard J; Burkard, Robert F; Coad, Mary Lou; Wack, David S; Galantowicz, Paul J; Lockwood, Alan H

    2004-08-01

    The auditory steady state response (aSSR) is an oscillatory electrical potential recorded from the scalp induced by amplitude-modulated (AM) or click/tone burst stimuli. Its clinical utility has been limited by uncertainty regarding the specific areas of the brain involved in its generation. To identify the generators of the aSSR, 15O-water PET imaging was used to locate the regions of the brain activated by a steady 1 kHz pure tone, the same tone amplitude modulated (AM) at 40 Hz and the specific regions of the brain responsive to the AM component of the stimulus relative to the continuous tone. The continuous tone produced four clusters of activation. The boundaries of these activated clusters extended to include regions in left primary auditory cortex, right non-primary auditory cortex, left thalamus, and left cingulate. The AM tone produced three clusters of activation. The boundaries of these activated clusters extended to include primary auditory cortex bilaterally, left medial geniculate and right middle frontal gyrus. Two regions were specifically responsive to the AM component of the stimulus. These activated clusters extended to include the right anterior cingulate near frontal cortex and right auditory cortex. We conclude that cortical sites, including areas outside primary auditory cortex, are involved in generating the aSSR. There was an unexpected difference between morning and afternoon session scans that may reflect a pre- versus post-prandial state. These results support the hypothesis that a distributed resonating circuit mediates the generation of the aSSR.

  4. A Discontinuous Galerkin Chimera Overset Solver

    NASA Astrophysics Data System (ADS)

    Galbraith, Marshall Christopher

    This work summarizes the development of an accurate, efficient, and flexible Computational Fluid Dynamics computer code that is an improvement relative to the state of the art. The improved accuracy and efficiency is obtained by using a high-order discontinuous Galerkin (DG) discretization scheme. In order to maximize the computational efficiency, quadrature-free integration and numerical integration optimized as matrix-vector multiplications is employed and implemented through a pre-processor (PyDG). Using the PyDG pre-processor, a C++ polynomial library has been developed that uses overloaded operators to design an efficient Domain Specific Language (DSL) that allows expressions involving polynomials to be written as if they are scalars. The DSL, which makes the syntax of computer code legible and intuitive, promotes maintainability of the software and simplifies the development of additional capabilities. The flexibility of the code is achieved by combining the DG scheme with the Chimera overset method. The Chimera overset method produces solutions on a set of overlapping grids that communicate through an exchange of data on grid boundaries (known as artificial boundaries). Finite volume and finite difference discretizations use fringe points, which are layers of points on the artificial boundaries, to maintain the interior stencil on artificial boundaries. The fringe points receive solution values interpolated from overset grids. Proper interpolation requires fringe points to be contained in overset grids. Insufficient overlap must be corrected by modifying the grid system. The Chimera scheme can also exclude regions of grids that lie outside the computational domain; a process commonly known as hole cutting. The Chimera overset method has traditionally enabled the use of high-order finite difference and finite volume approaches such as WENO and compact differencing schemes, which require structured meshes, for modeling fluid flow associated with complex

  5. [Discontinuation-Emergent Signs and Symptoms Inventory--Polish translation of the discontinuation signs and symptoms checklist].

    PubMed

    Cubała, Wiesław Jerzy; Landowski, Jerzy; Springer, Janusz

    2013-01-01

    A number of preclinical and clinical studies are focused on mechanisms of SSRI discontinuation syndrome as well as the patient populations and agents that are most affected by this phenomenon. Characteristics of onset, duration, and severity of any discontinuation symptoms and spontaneous reports of taper/poststudy-emergent adverse events should be compared with those of the active comparator in these studies. Besides, common clinical practice supplies a number of problems associated with SSRI discontinuation syndrome as related to treatment planning and management. The recommended instrument for evaluating SSRI discontinuation syndrome symptoms is the Discontinuation-Emergent Signs and Symptoms (DESS) inventory. DESS is a 43-item checklist that can be administered in a clinician-rated form, a self-rated form, or an interactive voice-response form. The paper presents the Polish version of DESS inventory along with its application and interpretation instructions. DESS inventory is of substantial advance in common psychiatric practice as it enables effective SSRI discontinuation management on drug tapering and in case of the non-compliance with the treatment. Its use in the systematic studies facilitates conclusive outcome results and is of prime importance as being comparable with literature outcomes. PMID:24946477

  6. development of a medium repetition rate (10 Hz - 500 Hz) diode pumped laser transmitter for airborne scanning altimetry

    NASA Technical Reports Server (NTRS)

    Coyle, D. Barry; Lindauer, Steven J., II; Kay, Richard B.

    1998-01-01

    Since the late 1980's, NASA has developed several small, all-solid state lasers of low repetition rates for use as transmitters in prototype LIDAR and raster scanned altimetry retrieval systems. Our early laser transmitters were developed for high resolution airborne altimetry which employed cavity dumping techniques to produce a pulse shape with a 1 ns rise time. The first such laser was the SUMR (Sub-millimeter resolution) transmitter which used a side pumped, D-shaped half-rod of Nd:YAG for the oscillator active media and produced approximately 3 ns pulses of 100 micro-J energy at a 40 Hz repetition rate. (Coyle and Blair, 1993; Coyle et al., 1995) After several upgrades to improve rep rate and pulse energy, the final version produced 1.2 mJ pulses at 120 Hz with a 3.7 ns pulse width. The laser has become known as SPLT (Sharp Pulsed Laser Transmitter), and has flown successfully on a variety of airborne altimetry missions. (Coyle and Blair, 1995; Blair et al., 1994) From building these systems, we have accrued valuable experience in delivering field-deployable lasers and have become aware of the advantages and disadvantages of employing new technologies. For example, even though the laser's main operating environment is in a "cold" aircraft during flight, the laser must still operate in very warm temperatures. This is important if the mission is based in the desert or a tropical climate since ground calibration data from stationary targets must be gathered before and after each data flight. Because conductive cooling is much more convenient than closed loop water flow, achieving the highest possible laser efficiency is becoming a high priority when designing a flight laser. This is especially true for lasers with higher pulse energies and repetition rates which are needed for high altitude scanning altimeters and LIDARs.

  7. Selective serotonin reuptake inhibitor discontinuation syndrome: proposed diagnostic criteria.

    PubMed Central

    Black, K; Shea, C; Dursun, S; Kutcher, S

    2000-01-01

    OBJECTIVE: To establish specific criteria by which selective serotonin reuptake inhibitor (SSRI) discontinuation syndrome may be identified. DATA SOURCES: MEDLINE and PSYCHLIT databases were searched for case reports published from 1986 to 1997 inclusive, and references of relevant articles were also searched. STUDY SELECTION: Forty-six case reports of symptoms following the discontinuation of fluoxetine, fluvoxamine, paroxetine or sertraline were selected. Three studies of SSRI discontinuation were also reviewed. DATA EXTRACTION: Demographic and treatment information, as well as the timing, duration, number, nature and frequency of dicontinuation symptoms. DATA SYNTHESIS: Paroxetine was most frequently implicated. The drug had been tapered in half of the cases. In some cases, symptom onset began during taper, whereas, in most cases, symptoms began within 1 to 3 days of drug discontinuation. Fifty-three different symptoms were reported, with dizziness being the most common. Other common symptoms were nausea or emesis, fatigue, headache, gait instability and insomnia. Shock-like sensations, paresthesia and visual disturbances were the most rare. Without intervention, symptoms persisted for more than a week in half of the cases. In cases in which the SSRI was restarted, symptoms resolved within 72 hours. In some cases, withdrawal symptoms recurred when the same SSRI was again discontinued. CONCLUSIONS: Findings were used to construct diagnostic criteria for the SSRI discontinuation syndrome. These criteria are 2 or more of the following symptoms developing within 1 to 7 days of discontinuation or reduction in dosage of an SSRI after at least 1 month's use, when these symptoms cause clinically significant distress or impairment and are not due to a general medical condition or recurrence of a mental disorder: dizziness, light-headedness, vertigo or feeling faint; shock-like sensations or paresthesia; anxiety; diarrhea; fatigue; gait instability; headache; insomnia

  8. Seismic array constraints on the D″ discontinuity beneath Central America

    NASA Astrophysics Data System (ADS)

    Whittaker, Stefanie; Thorne, Michael S.; Schmerr, Nicholas C.; Miyagi, Lowell

    2016-01-01

    We analyzed 16,150 transverse component seismic recordings from 54 deep-focus earthquakes in the South American and Caribbean regions recorded at broadband stations in North America between 2005 and 2012. We treated subgroups of seismic stations within 3° radius geographical bins as seismic arrays and performed vespagram analysis. We focused on the S, ScS, and Scd arrivals and collected data in the epicentral distance range from 55° to 90°. In particular, we searched for D″ discontinuity presence in the vespagrams in a 25° by 35° (or 1520 by 2130 km) area beneath Central America. Analysis of these data showed 125 clear Scd observations, 180 Scd observations of lesser quality, and 343 nonobservations. We produced a new map of the discontinuity height beneath Central America. Our map shows an average discontinuity height of 286 ± 6 km (σ = 76 km). The region is punctuated by a large topographic high centered at approximately 10°N and 90°W with a maximum height of 380 km. Two smaller topographic highs are located at approximately 4°N and 81°W (discontinuity height of 320 km) and at 4°N and 70°W (height of 315 km). The observation of multiple Scd arrivals collocated with the strongest gradients in inferred topography provides evidence for topographic variation on the discontinuity rather than multiple discontinuities. The regions where the discontinuity has the greatest height can be explained by localized enrichment of mid-ocean ridge basalt from the subducted Farallon slab impinging on the core-mantle boundary.

  9. 47 CFR 15.219 - Operation in the band 510-1705 kHz.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Operation in the band 510-1705 kHz. 15.219... kHz. (a) The total input power to the final radio frequency stage (exclusive of filament or heater... ground lead (if used) shall not exceed 3 meters. (c) All emissions below 510 kHz or above 1705 kHz...

  10. 47 CFR 15.219 - Operation in the band 510-1705 kHz.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Operation in the band 510-1705 kHz. 15.219... kHz. (a) The total input power to the final radio frequency stage (exclusive of filament or heater... ground lead (if used) shall not exceed 3 meters. (c) All emissions below 510 kHz or above 1705 kHz...

  11. 47 CFR 15.219 - Operation in the band 510-1705 kHz.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Operation in the band 510-1705 kHz. 15.219... kHz. (a) The total input power to the final radio frequency stage (exclusive of filament or heater... ground lead (if used) shall not exceed 3 meters. (c) All emissions below 510 kHz or above 1705 kHz...

  12. 47 CFR 15.219 - Operation in the band 510-1705 kHz.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Operation in the band 510-1705 kHz. 15.219... kHz. (a) The total input power to the final radio frequency stage (exclusive of filament or heater... ground lead (if used) shall not exceed 3 meters. (c) All emissions below 510 kHz or above 1705 kHz...

  13. 47 CFR 15.219 - Operation in the band 510-1705 kHz.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Operation in the band 510-1705 kHz. 15.219... kHz. (a) The total input power to the final radio frequency stage (exclusive of filament or heater... ground lead (if used) shall not exceed 3 meters. (c) All emissions below 510 kHz or above 1705 kHz...

  14. The effect of mechanical discontinuities on the growth of faults

    NASA Astrophysics Data System (ADS)

    Bonini, Lorenzo; Basili, Roberto; Bonanno, Emanuele; Toscani, Giovanni; Burrato, Pierfrancesco; Seno, Silvio; Valensise, Gianluca

    2016-04-01

    The growth of natural faults is controlled by several factors, including the nature of host rocks, the strain rate, the temperature, and the presence of fluids. In this work we focus on the mechanical characteristics of host rocks, and in particular on the role played by thin mechanical discontinuities on the upward propagation of faults and on associated secondary effects such as folding and fracturing. Our approach uses scaled, analogue models where natural rocks are simulated by wet clay (kaolin). A clay cake is placed above two rigid blocks in a hanging wall/footwall configuration on either side of a planar fault. Fault activity is simulated by motor-controlled movements of the hanging wall. We reproduce three types of faults: a 45°-dipping normal fault, a 45°-dipping reverse fault and a 30°-dipping reverse fault. These angles are selected as representative of most natural dip-slip faults. The analogues of the mechanical discontinuities are obtained by precutting the wet clay cake before starting the hanging wall movement. We monitor the experiments with high-resolution cameras and then obtain most of the data through the Digital Image Correlation method (D.I.C.). This technique accurately tracks the trajectories of the particles of the analogue material during the deformation process: this allows us to extract displacement field vectors plus the strain and shear rate distributions on the lateral side of the clay block, where the growth of new faults is best seen. Initially we run a series of isotropic experiments, i.e. experiments without discontinuities, to generate a reference model: then we introduce the discontinuities. For the extensional models they are cut at different dip angles, from horizontal to 45°-dipping, both synthetic and antithetic with respect to the master fault, whereas only horizontal discontinuities are introduced in the contractional models. Our experiments show that such discontinuities control: 1) the propagation rate of faults

  15. The Effect of the 226-Hz Probe Level on Contralateral Acoustic Stapedius Reflex Thresholds

    ERIC Educational Resources Information Center

    Day, Jessica E.; Feeney, M. Patrick

    2008-01-01

    Purpose: The purpose of this study was to examine the effect of the 226-Hz probe level on the acoustic stapedius reflex threshold. Method: Contralateral reflex thresholds for a 1000-Hz pure-tone stimulus were obtained from 40 young adults with normal hearing using an experimental system at four 226-Hz probe levels (70, 75, 80, and 85 dB SPL) with…

  16. 47 CFR 15.221 - Operation in the band 525-1705 kHz.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Operation in the band 525-1705 kHz. 15.221... kHz. (a) Carrier current systems and transmitters employing a leaky coaxial cable as the radiating antenna may operate in the band 525-1705 kHz provided the field strength levels of the radiated...

  17. 47 CFR 80.147 - Watch on 2182 kHz.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Watch on 2182 kHz. 80.147 Section 80.147 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE... 2182 kHz. Ship stations must maintain a watch on 2182 kHz as prescribed by § 80.304....

  18. 47 CFR 15.221 - Operation in the band 525-1705 kHz.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Operation in the band 525-1705 kHz. 15.221... kHz. (a) Carrier current systems and transmitters employing a leaky coaxial cable as the radiating antenna may operate in the band 525-1705 kHz provided the field strength levels of the radiated...

  19. 47 CFR 90.253 - Use of frequency 5167.5 kHz.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Use of frequency 5167.5 kHz. 90.253 Section 90.253 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES... frequency 5167.5 kHz. The frequency 5167.5 kHz may be used by any station authorized under this part...

  20. 47 CFR 80.147 - Watch on 2182 kHz.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Watch on 2182 kHz. 80.147 Section 80.147 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE... 2182 kHz. Ship stations must maintain a watch on 2182 kHz as prescribed by § 80.304....

  1. 47 CFR 90.253 - Use of frequency 5167.5 kHz.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Use of frequency 5167.5 kHz. 90.253 Section 90.253 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES... frequency 5167.5 kHz. The frequency 5167.5 kHz may be used by any station authorized under this part...

  2. 47 CFR 90.253 - Use of frequency 5167.5 kHz.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Use of frequency 5167.5 kHz. 90.253 Section 90.253 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES... frequency 5167.5 kHz. The frequency 5167.5 kHz may be used by any station authorized under this part...

  3. 47 CFR 90.253 - Use of frequency 5167.5 kHz.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Use of frequency 5167.5 kHz. 90.253 Section 90.253 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES... frequency 5167.5 kHz. The frequency 5167.5 kHz may be used by any station authorized under this part...

  4. 47 CFR 90.253 - Use of frequency 5167.5 kHz.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Use of frequency 5167.5 kHz. 90.253 Section 90.253 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES... frequency 5167.5 kHz. The frequency 5167.5 kHz may be used by any station authorized under this part...

  5. 47 CFR 80.147 - Watch on 2182 kHz.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Watch on 2182 kHz. 80.147 Section 80.147 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE... 2182 kHz. Ship stations must maintain a watch on 2182 kHz as prescribed by § 80.304....

  6. 47 CFR 80.147 - Watch on 2182 kHz.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Watch on 2182 kHz. 80.147 Section 80.147 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE... 2182 kHz. Ship stations must maintain a watch on 2182 kHz as prescribed by § 80.304....

  7. 47 CFR 15.221 - Operation in the band 525-1705 kHz.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Operation in the band 525-1705 kHz. 15.221... kHz. (a) Carrier current systems and transmitters employing a leaky coaxial cable as the radiating antenna may operate in the band 525-1705 kHz provided the field strength levels of the radiated...

  8. 47 CFR 15.221 - Operation in the band 525-1705 kHz.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Operation in the band 525-1705 kHz. 15.221... kHz. (a) Carrier current systems and transmitters employing a leaky coaxial cable as the radiating antenna may operate in the band 525-1705 kHz provided the field strength levels of the radiated...

  9. 47 CFR 15.221 - Operation in the band 525-1705 kHz.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Operation in the band 525-1705 kHz. 15.221... kHz. (a) Carrier current systems and transmitters employing a leaky coaxial cable as the radiating antenna may operate in the band 525-1705 kHz provided the field strength levels of the radiated...

  10. 47 CFR 80.147 - Watch on 2182 kHz.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Watch on 2182 kHz. 80.147 Section 80.147 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE... 2182 kHz. Ship stations must maintain a watch on 2182 kHz as prescribed by § 80.304....

  11. Discontinuous dual-primal mixed finite elements for elliptic problems

    NASA Technical Reports Server (NTRS)

    Bottasso, Carlo L.; Micheletti, Stefano; Sacco, Riccardo

    2000-01-01

    We propose a novel discontinuous mixed finite element formulation for the solution of second-order elliptic problems. Fully discontinuous piecewise polynomial finite element spaces are used for the trial and test functions. The discontinuous nature of the test functions at the element interfaces allows to introduce new boundary unknowns that, on the one hand enforce the weak continuity of the trial functions, and on the other avoid the need to define a priori algorithmic fluxes as in standard discontinuous Galerkin methods. Static condensation is performed at the element level, leading to a solution procedure based on the sole interface unknowns. The resulting family of discontinuous dual-primal mixed finite element methods is presented in the one and two-dimensional cases. In the one-dimensional case, we show the equivalence of the method with implicit Runge-Kutta schemes of the collocation type exhibiting optimal behavior. Numerical experiments in one and two dimensions demonstrate the order accuracy of the new method, confirming the results of the analysis.

  12. Midcrustal discontinuities and the assembly of the Himalayan midcrust

    NASA Astrophysics Data System (ADS)

    Larson, Kyle P.; Cottle, John M.

    2014-05-01

    Detailed quartz lattice preferred orientation (LPO) data define two structural discontinuities in the exhumed high-grade metamorphic core of the Himalaya exposed in the upper Tama Kosi region of east central Nepal. The structures are marked by abrupt breaks in a general trend of up structural section increasing quartz LPO-defined deformation temperatures. Deformation associated with the upper structural discontinuity, which occurs within sillimanite grade rocks, is postpeak metamorphism in both the hanging wall and the footwall. New geochronologic data constrain the timing of metamorphism in the hanging wall of the upper discontinuity to between 24 and 16 Ma, indistinguishable from previously published ages for the footwall. Movement across this structure represents Early Miocene strain localization and thickening in the Himalayan midcrust. Movement across the lower discontinuity, which occurs between staurolite and kyanite grade rocks, appears to be synmetamorphic with material in its footwall at approximately 10 Ma, but postpeak metamorphism for material in its hanging wall. This movement is interpreted to reflect the underplating and incorporation of material into the metamorphic core. The recognition of two thrust-sense discontinuities in the exhumed Himalayan core in the Tama Kosi region is consistent with other similar structures recognized along the Himalaya. The widespread nature of these structures reinforces that they are important to our understanding of the evolution of the kinematics of large, hot orogens.

  13. Solutions of the Wheeler-Feynman equations with discontinuous velocities.

    PubMed

    de Souza, Daniel Câmara; De Luca, Jayme

    2015-01-01

    We generalize Wheeler-Feynman electrodynamics with a variational boundary value problem for continuous boundary segments that might include velocity discontinuity points. Critical-point orbits must satisfy the Euler-Lagrange equations of the action functional at most points, which are neutral differential delay equations (the Wheeler-Feynman equations of motion). At velocity discontinuity points, critical-point orbits must satisfy the Weierstrass-Erdmann continuity conditions for the partial momenta and the partial energies. We study a special setup having the shortest time-separation between the (infinite-dimensional) boundary segments, for which case the critical-point orbit can be found using a two-point boundary problem for an ordinary differential equation. For this simplest setup, we prove that orbits can have discontinuous velocities. We construct a numerical method to solve the Wheeler-Feynman equations together with the Weierstrass-Erdmann conditions and calculate some numerical orbits with discontinuous velocities. We also prove that the variational boundary value problem has a unique solution depending continuously on boundary data, if the continuous boundary segments have velocity discontinuities along a reduced local space.

  14. Solutions of the Wheeler-Feynman equations with discontinuous velocities.

    PubMed

    de Souza, Daniel Câmara; De Luca, Jayme

    2015-01-01

    We generalize Wheeler-Feynman electrodynamics with a variational boundary value problem for continuous boundary segments that might include velocity discontinuity points. Critical-point orbits must satisfy the Euler-Lagrange equations of the action functional at most points, which are neutral differential delay equations (the Wheeler-Feynman equations of motion). At velocity discontinuity points, critical-point orbits must satisfy the Weierstrass-Erdmann continuity conditions for the partial momenta and the partial energies. We study a special setup having the shortest time-separation between the (infinite-dimensional) boundary segments, for which case the critical-point orbit can be found using a two-point boundary problem for an ordinary differential equation. For this simplest setup, we prove that orbits can have discontinuous velocities. We construct a numerical method to solve the Wheeler-Feynman equations together with the Weierstrass-Erdmann conditions and calculate some numerical orbits with discontinuous velocities. We also prove that the variational boundary value problem has a unique solution depending continuously on boundary data, if the continuous boundary segments have velocity discontinuities along a reduced local space. PMID:25637913

  15. Imaging Resolution of the 410-km and 660-km Discontinuities

    NASA Astrophysics Data System (ADS)

    Deng, K.; Zhou, Y.

    2014-12-01

    Structure of seismic discontinuities at depths of about 410 km and 660 km provides important constraints on mantle convection as the associated phase transformations in the transition zone are sensitive to thermal perturbations. Teleseismic P-to-S receiver functions have been widely used to map the depths of the two discontinuities. In this study, we investigate the resolution of receiver functions in imaging topographic variations of the 410-km and 660-km discontinuities based on wave propagation simulations using the Spectral Element Method (SEM). We investigate finite-frequency effects of direct P waves as well as P-to-S converted waves by varying the length scale of discontinuity topography in the transition zone. We show that wavefront healing effects are significant in broadband receiver functions. For example, at a period of 10 to 20 seconds, the arrival anomaly in P-to-S converted waves is about 50% of what predicted by ray theory when the topography length scale is in the order of 400 km. The observed arrival anomaly further reduces to 10-20% when the topography length scale reduces to about 200 km. We calculate 2-D boundary sensitivity kernels for direct P waves as well as receiver functions based on surface wave mode summation and confirm that finite frequency-effects can be properly accounted for. Three-dimensional wavespeed structure beneath seismic stations can also introduce significant artifacts in transition zone discontinuity topography if time corrections are not applied, and, the effects are dependent on frequency.

  16. 20 kHz Space Station power system

    NASA Technical Reports Server (NTRS)

    Hansen, Irving G.; Wolff, Fredrick J.

    1986-01-01

    The Space Station represents the next major U.S. commitment in space. The efficient delivery of power to multiple user loads is key to that success. In 1969, NASA Lewis Research Center began a series of studies with component and circuit developments that led to the high frequency bi-directional, four quadrant resonant driven converter. Additional studies and subsequent developments into the early 1980's have shown how the high frequency ac power system could provide overall advantages to many aerospace power systems. Because of its wide versatility, it also has outstanding advantages for the Space Station Program and its wide range of users. High frequency ac power provides higher efficiency, lower cost, and improved safety. The 20 kHz power system has exceptional flexibility, is inherently user friendly, and is compatible with all types of energy sources - photovoltaic, solar dynamic, rotating machines or nuclear Lewis distribution system testbed. The testbed demonstrates flexibility, versatility, and transparency to user technology as well as high efficiency, low mass, and reduced volume.

  17. Cardiovascular response of rats exposed to 60-Hz electric fields

    SciTech Connect

    Hilton, D.I.; Phillips, R.D.

    1980-01-01

    Recently, it has been reported that exposure to high-strength electric fields can influence electrocardiogram (ECG) patterns, heart rates, and blood pressures in various species of animals. Our studies were designed to evaluate these reported effects and to help clarify some of the disagreement present in the literature. Various cardiovascular variables were measured in Sprague-Dawley rats exposed or sham-exposed to 60-Hz electric fields at 80 to 100 kV/m for periods up to four months. No significant differences in heart rates, ECG patterns, blood pressures, or vascular reactivity were observed between exposed and sham-exposed rats after 8 hours, 40 hours, 1 month, or 4 months of exposure. Our studies cannot be directly compared to the work of other investigators because of differences in animal species and electric-field characteristics. However, our failure to detect any cardiovascular changes may have been the result of (1) eliminating secondary field effects such as shocks, audible noise, corona, and ozone; (2) minimizing steady-state microcurrents between the mouth of the animal and watering devices; and (3) minimizing electric-field-induced vibration of the electrodes and animal cages.

  18. Evidence for a High-Pressure Phase Transition of ε-2,4,6,8,10,12-hexanitrohexaazaisowurtzitane (CL-20) Using Vibrational Spectroscopy

    SciTech Connect

    Ciezak, J.; Jenkins, T; Liu, Z

    2007-01-01

    The high-pressure response of {epsilon}-2,4,6,8,10,12-hexanitrohexaazaisowurtizane (CL-20) has been examined to 27 GPa in diamond anvil cells using vibrational spectroscopy. The results reveal evidence of an {epsilon}{yields}{Upsilon} pressure-induced phase transition between 4.1 and 6.4 GPa and suggest the existence of a {Upsilon}{yields}{zeta} transition near 18.7 GPa. Several Raman and infrared frequencies were found to decrease in intensity as the phase boundaries are approached. An anomalous intensity increase was noted in the C-N-C infrared mode that is believed to result from an increase in the Raman cross-section due to a stronger interlayer coupling under pressure.

  19. The parent-rated social skills of a sample of New York City preschool children 8-10 months after September 11, 2001.

    PubMed

    Yasik, Anastasia E; Saigh, Philip A; Mitchell, Pamela; Abright, A Reese

    2010-01-01

    This study compared the Social Skills Rating System-Preschool Parent Version ratings of two groups of New York City preschool children 8-10 months after September 11, 2001. One group of children was within 1 mile (1.61 km) of the World Trade Center (WTC) during the attack and exposed to one or more traumatic events. The second group was 2.04 to 14 miles (3.28-22.54 km) away from the WTC and not exposed to traumatic events. The social skills ratings of the comparison groups did not significantly differ These outcomes were consistent after statistically adjusting for the potentially confounding influence of parental PTSD, anxiety, and depression symptoms. PMID:21870383

  20. Critical behavior and its correlation with magnetocaloric effect in amorphous Fe80-xVxB12Si8 (x=8, 10 and 13.7) alloys

    NASA Astrophysics Data System (ADS)

    Boutahar, A.; Lassri, H.; Hlil, E. K.; Fruchart, D.

    2016-01-01

    The critical exponents in Fe80-xVxB12Si8 (x=8, 10 and 13.7) amorphous alloys were investigated near ferromagnetic to paramagnetic phase transition temperature. All amorphous alloys exhibit a second order ferromagnetic to paramagnetic phase transition (SOMT). The critical exponents (β, γ and δ) were estimated using the modified Arrott plot technique (MAP), the Widom scaling relation (WSR), and the critical isotherm analysis (CIA). In addition, an independent analysis of the critical behavior is presented in terms of the magnetocaloric effect (MCE). It shows in accordance with conclusion from magnetization data analysis. The estimated critical exponent values are found to be consistent and comparable to those predicted by the mean field model. This result points out to the ferromagnetic exchange interaction of long-range type.

  1. Tmprss3, a Transmembrane Serine Protease Deficient in Human DFNB8/10 Deafness, Is Critical for Cochlear Hair Cell Survival at the Onset of Hearing*

    PubMed Central

    Fasquelle, Lydie; Scott, Hamish S.; Lenoir, Marc; Wang, Jing; Rebillard, Guy; Gaboyard, Sophie; Venteo, Stéphanie; François, Florence; Mausset-Bonnefont, Anne-Laure; Antonarakis, Stylianos E.; Neidhart, Elizabeth; Chabbert, Christian; Puel, Jean-Luc; Guipponi, Michel; Delprat, Benjamin

    2011-01-01

    Mutations in the type II transmembrane serine protease 3 (TMPRSS3) gene cause non-syndromic autosomal recessive deafness (DFNB8/10), characterized by congenital or childhood onset bilateral profound hearing loss. In order to explore the physiopathology of TMPRSS3 related deafness, we have generated an ethyl-nitrosourea-induced mutant mouse carrying a protein-truncating nonsense mutation in Tmprss3 (Y260X) and characterized the functional and histological consequences of Tmprss3 deficiency. Auditory brainstem response revealed that wild type and heterozygous mice have normal hearing thresholds up to 5 months of age, whereas Tmprss3Y260X homozygous mutant mice exhibit severe deafness. Histological examination showed degeneration of the organ of Corti in adult mutant mice. Cochlear hair cell degeneration starts at the onset of hearing, postnatal day 12, in the basal turn and progresses very rapidly toward the apex, reaching completion within 2 days. Given that auditory and vestibular deficits often co-exist, we evaluated the balancing abilities of Tmprss3Y260X mice by using rotating rod and vestibular behavioral tests. Tmprss3Y260X mice effectively displayed mild vestibular syndrome that correlated histologically with a slow degeneration of saccular hair cells. In situ hybridization in the developing inner ear showed that Tmprss3 mRNA is localized in sensory hair cells in the cochlea and the vestibule. Our results show that Tmprss3 acts as a permissive factor for cochlear hair cells survival and activation at the onset of hearing and is required for saccular hair cell survival. This mouse model will certainly help to decipher the molecular mechanisms underlying DFNB8/10 deafness and cochlear function. PMID:21454591

  2. Effect of Training School Teachers on Oral Hygiene Status of 8-10 Years Old Government School Children of Udaipur City, India

    PubMed Central

    Bhat, Nagesh; Asawa, Kailash; Tak, Mridula; Singh, Anukriti; Shinde, Kushal; Gandhi, Neha; Doshi, Astha

    2016-01-01

    Introduction Provision of oral health knowledge to the children by their teachers at the school level can prove to be more fruitful because it is the time period during which the children begin to learn the basic oral hygiene practices and are most prone to dental caries. Aim This study was carried out to assess the effect of training school teachers on oral hygiene status of 8-10 years old government school children of Udaipur city, India. Materials and Methods A total of nine school teachers and 279, 8-10 year old school children from two government schools were included in the study. The questionnaire on oral health knowledge and practice contained 17 questions to evaluate the knowledge and practice of children towards oral hygiene before and after the teachers training program. Baseline and six months post training data on oral health knowledge and practice was obtained by the questionnaire method. Baseline and six months post training data on oral hygiene status was obtained by OHI-S Index. Statistical analysis was done using software SPSS 22, the test used were McNemar’s test, paired t-test. Results Pre and post training data were compared and it was found that there was a significant improvement in oral health knowledge and practices of school teachers and children. Also oral hygiene status of school children was significantly improved after the program. Conclusion Results of the present study suggest that experiential learning is an effective school based oral health education method for improvement of oral hygiene in primary school children. PMID:27656573

  3. Final Technical Report ''Double discontinuities in space plasma''

    SciTech Connect

    Yun Chow Whang

    2004-05-13

    This research used high-resolution magnetic field data to examine the interior structures of MHD shocks in interplanetary space and in the magnetotail; we discovered that a slow-mode shock is often followed by an adjoining rotational discontinuity layer on the postshock side. The thickness of each layer is of the order of a few ion inertial lengths. Such a compound structure is known as a double discontinuity. When the magnetic field rotates by several degrees per ion inertial length inside a thin layer, the Hall current term becomes important in the generalized Ohm's law. Steady state solutions based on the Hall-MHD theory have been obtained to show the merging of a rotational layer and a slow shock layer to form a compound structure like the observed double discontinuities.

  4. Resolution properties of the Fourier method for discontinuous waves

    NASA Technical Reports Server (NTRS)

    Gottlieb, David; Shu, Chi-Wang

    1992-01-01

    In this paper we discuss the wave-resolution properties of the Fourier approximations of a wave function with discontinuities. It is well known that a minimum of two points per wave is needed to resolve a periodic wave function using Fourier expansions. For Chebyshev approximations of a wave function, a minimum of pi points per wave is needed. Here we obtain an estimate for the minimum number of points per wave to resolve a discontinuous wave based on its Fourier coefficients. In our recent work on overcoming the Gibbs phenomenon, we have shown that the Fourier coefficients of a discontinuous function contain enough information to reconstruct with exponential accuracy the coefficient of a rapidly converging Gegenbauer expansion. We therefore study the resolution properties of a Gegenbauer expansion where both the number of terms and the order increase.

  5. The effect of acute discontinuation of total parenteral nutrition.

    PubMed Central

    Wagman, L D; Newsome, H H; Miller, K B; Thomas, R B; Weir, G C

    1986-01-01

    The present study was undertaken to assess the impact of acute discontinuation (AD) of total parenteral nutrition (TPN) on serum glucose, insulin, and glucagon levels and on the generation of symptomatic hypoglycemia. Fifty studies were performed in 48 patients. In none of the 30 studies of 1 hour duration nor in the 20 studies of 8 hours duration was there a single episode of symptomatic hypoglycemia. One patient had a glucose below normal (60 mg/dl) during the first hour after AD. Glucose and insulin concentrations were elevated at the start of TPN discontinuation but returned to normal values within 60 minutes and remained there during the successive 7 hours of study. Although glucagon levels were slightly elevated at zero time, no significant decrease occurred. There was no evidence for counter-regulation based on the patterns of glucose and hormone levels. With some restrictions, acute discontinuation is a safe, rapid method of ending a prolonged TPN infusion. PMID:3094465

  6. Discontinuous phase transition in a dimer lattice gas

    NASA Astrophysics Data System (ADS)

    Dickman, Ronald

    2012-05-01

    I study a dimer model on the square lattice with nearest neighbor exclusion as the only interaction. Detailed simulations using tomographic entropic sampling show that as the chemical potential is varied, there is a strongly discontinuous phase transition, at which the particle density jumps by about 18% of its maximum value, 1/4. The transition is accompanied by the onset of orientational order, to an arrangement corresponding to the {1/2, 0, 1/2} structure identified by Phares et al. [Physica B 409, 1096 (2011)] in a dimer model with finite repulsion at fixed density. Using finite-size scaling and Binder's cumulant, the expected scaling behavior at a discontinuous transition is verified in detail. The discontinuous transition can be understood qualitatively given that the model possesses eight equivalent maximum-density configurations, so that its coarse-grained description corresponds to that of the q = 8 Potts model.

  7. Discontinuities of BFKL amplitudes and the BDS ansatz

    NASA Astrophysics Data System (ADS)

    Fadin, V. S.; Fiore, R.

    2015-12-01

    We perform an examination of discontinuities of multiple production amplitudes, which are required for further development of the BFKL approach. It turns out that the discontinuities of 2 → 2 + n amplitudes obtained in the BFKL approach contradict to the BDS ansatz for amplitudes with maximal helicity violation in N = 4 supersymmetric Yang-Mills theory with large number of colors starting with n = 2. Explicit expressions for the discontinuities of the 2 → 3 and 2 → 4 amplitudes in the invariant mass of pairs of produced gluons are obtained in the planar N = 4 SYM in the next-to-leading logarithmic approximation. These expressions can be used for checking the conjectured duality between the light-like Wilson loops and the MHV amplitudes.

  8. On the structure of contact binaries. I - The contact discontinuity

    NASA Technical Reports Server (NTRS)

    Shu, F. H.; Lubow, S. H.; Anderson, L.

    1976-01-01

    The problem of the interior structure of contact binaries is reviewed, and a simple resolution of the difficulties which plague the theory is suggested. It is proposed that contact binaries contain a contact discontinuity between the lower surface of the common envelope and the Roche lobe of the cooler star. This discontinuity is maintained against thermal diffusion by fluid flow, and the transition layer is thin to the extent that the dynamical time scale is short in comparison with the thermal time scale. The idealization that the transition layer has infinitesimal thickness allows a simple formulation of the structure equations which are closed by appropriate jump conditions across the discontinuity. The further imposition of the standard boundary conditions suffices to define a unique model for the system once the chemical composition, the masses of the two stars, and the orbital separation are specified.

  9. A tessellated continuum approach to thermal analysis: discontinuity networks

    NASA Astrophysics Data System (ADS)

    Jiang, C.; Davey, K.; Prosser, R.

    2016-08-01

    Tessellated continuum mechanics is an approach for the representation of thermo-mechanical behaviour of porous media on tessellated continua. It involves the application of iteration function schemes using affine contraction and expansion maps, respectively, for the creation of porous fractal materials and associated tessellated continua. Highly complex geometries can be produced using a modest number of contraction mappings. The associated tessellations form the mesh in a numerical procedure. This paper tests the hypothesis that thermal analysis of porous structures can be achieved using a discontinuous Galerkin finite element method on a tessellation. Discontinuous behaviour is identified at a discontinuity network in a tessellation; its use is shown to provide a good representation of the physics relating to cellular heat exchanger designs. Results for different cellular designs (with corresponding tessellations) are contrasted against those obtained from direct analysis and very high accuracy is observed.

  10. Fertility and contraceptive adoption and discontinuation in rural Kenya.

    PubMed

    Ferguson, A G

    1992-01-01

    After a long period of slow progress, the recent uptake of contraceptive use in Kenya has been dramatic. This report describes adoption of a method and method switching and discontinuation among a cohort of married women aged 25-34 in two contrasting rural areas. A retrospective "fertility diary" completed by each woman provided information on spousal separation, reproductive status, and contraceptive use over a period of 46-48 months. Contraceptive prevalence rose rapidly over the period in both areas, with significant net adoption of injectables in both areas and of IUDs in one only. Method discontinuation was concentrated among users of pills, barrier methods, and "natural" methods, and only one-third of all discontinuations were voluntary. The wide differences between the two rural areas in contraceptive prevalence were not totally reflected in recent fertility levels, and the contribution of other proximate determinants of fertility, particularly postpartum amenorrhea and spousal separation, are discussed.

  11. The 2 Hz and 15 Hz electroacupuncture induced reverse effect on autonomic function in healthy adult using a heart rate variability analysis

    PubMed Central

    Jia, Bor-An; Cheng, Chin-Yi; Lin, Yi-Wen; Li, Tsai-Chung; Liu, Hsu-Jan; Hsieh, Ching-Liang

    2011-01-01

    The purpose of the present study was to investigate effect of electro-acupuncture (EA) at different frequencies on autonomic function. Twenty healthy adult volunteers were studied, and underwent 4 sessions of EA (sham, 2 Hz, 15 Hz, and 50 Hz). Sham, 2 Hz, 15 Hz, and 50 Hz EA was applied to the bilateral Leg Three Li (足三里 zú sān lǐ, ST-36) and Upper Great Hollow (上巨虛 shàng jù xū, ST-37) acupoints. The intensity of electrical stimulation was adjusted to obtain visible twitching of the anterior tibial muscle about 2.0-2.5 mA except sham without electrical stimulation. The components of heart rate variability (HRV) and blood pressure were measured before EA (BLP), EA (EAP), and post-EA periods (PEP). The results indicated that the natural logarithmic high frequency power (lnHF) of HRV was greater during PEP than during the BLP in the 2 Hz EA sessions. The natural logarithmic low frequency power (lnLF) of HRV was greater during the PEP than during the BLP in 15 Hz EA sessions, suggesting that 2 Hz EA apply to Leg Three Li (足三里 zú sān lǐ, ST-36) and Upper Great Hollow (上巨虛 shàng jù xū, ST-37) acupoints increased vagal activity, whereas 15 Hz EA increased sympathetic activity. PMID:24716105

  12. Are 1,5- and 1,7-dihydrodiimidazo[4,5-b:4‧,5‧-e]pyrazine the main products of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) alkaline hydrolysis? A DFT study of vibrational spectra

    NASA Astrophysics Data System (ADS)

    Kholod, Yana; Okovytyy, Sergiy; Kuramshina, Gulnara; Qasim, Mohammad; Gorb, Leonid; Furey, John; Honea, Patricia; Fredrickson, Herbert; Leszczynski, Jerzy

    2006-08-01

    The fully optimized geometries and force fields of the most stable conformation of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane and two tautomers 1,5- and 1,7-dihydrodiimidazo[4,5- b:4',5'- e]pyrazine were obtained at the B3LYP level of hybrid density functional theory with the 6-31G(d) basis set. The vibrational frequencies were calculated by scaling of force fields, and the vibrational spectra were interpreted taking into account potential energy distributions. DFT calculations provide good agreement between calculated and experimental vibrational frequencies, obtained for CL-20. The theoretical vibrational spectra of 1,5- and 1,7-dihydrodiimidazo[4,5- b:4',5'- e]pyrazine correspond to the experimental FTIR spectrum obtained for the CL-20 alkaline hydrolysis products.

  13. Disparities in Discontinuing Rosiglitazone Following the 2007 FDA Safety Alert

    PubMed Central

    Qato, Danya M.; Trivedi, Amal N.; Mor, Vincent; Dore, David D.

    2016-01-01

    Background Responsiveness to the Food and Drug Administration (FDA) rosiglitazone safety alert, issued on May 21, 2007, has not been examined among vulnerable subpopulations of the elderly. Objective To compare time to discontinuation of rosiglitazone after the safety alert between black and white elderly persons, and across sociodemographic and economic subgroups. Research Design A cohort study. Subjects Medicare fee-for-service enrollees in 2007 who were established users of rosiglitazone identified from a 20% national sample of pharmacy claims. Measures Outcome of interest was time to discontinuation of rosiglitazone after the May alert. We modeled the number of days following the warning to the end of the days’ supply for the last rosiglitazone claim during the study period (May 21, 2007–December 31, 2007) using multivariable proportional hazards models. Results More than 67% of enrollees discontinued rosiglitazone within six months of the advisory. In adjusted analysis, white enrollees (hazard ratio = 0.90; 95% confidence interval, 0.86–0.94) discontinued rosiglitazone later than the comparison group of black enrollees. Enrollees with a history of low personal income also discontinued later than their comparison group (hazard ratio = 0.84; 95% confidence interval, 0.81–0.87). There were no observed differences across quintiles of area-level socioeconomic status. Conclusions White race and a history of low personal income modestly predicted later discontinuation of rosiglitazone after the FDA’s safety advisory in 2007. The impact of FDA advisories can vary among sociodemographic groups. Policymakers should continue to monitor whether risk management policies reach their intended populations. PMID:26978569

  14. A comparative study between shielded and open coplanar waveguide discontinuities

    NASA Technical Reports Server (NTRS)

    Dib, Nihad I.; Harokopus, W. P., Jr.; Ponchak, G. E.; Katehi, L. P. B.

    1993-01-01

    A comparative study between open and shielded coplanar waveguide (CPW) discontinuities is presented. The space domain integral equation method is used to characterize several discontinuities such as the open-end CPW and CPW series stubs. Two different geometries of CPW series stubs (straight and bent stubs) are compared with respect to resonant frequency and radiation loss. In addition, the encountered radiation loss due to different CPW shunt stubs is evaluated experimentally. The notion of forced radiation simulation is presented, and the results of such a simulation are compared to the actual radiation loss obtained rigorously. It is shown that such a simulation cannot give reliable results concerning radiation loss from printed circuits.

  15. Discontinuous Galerkin finite element methods for gradient plasticity.

    SciTech Connect

    Garikipati, Krishna.; Ostien, Jakob T.

    2010-10-01

    In this report we apply discontinuous Galerkin finite element methods to the equations of an incompatibility based formulation of gradient plasticity. The presentation is motivated with a brief overview of the description of dislocations within a crystal lattice. A tensor representing a measure of the incompatibility with the lattice is used in the formulation of a gradient plasticity model. This model is cast in a variational formulation, and discontinuous Galerkin machinery is employed to implement the formulation into a finite element code. Finally numerical examples of the model are shown.

  16. Trapped electromagnetic modes in a waveguide with a small discontinuity

    NASA Astrophysics Data System (ADS)

    Stupakov, G. V.; Kurennoy, S. S.

    1994-01-01

    We demonstrate that a small discontinuity (such as an enlargement or a hole) on a smooth waveguide can result in the appearance of trapped modes localized in the vicinity of the discontinuity. The frequencies of these modes lie slightly below the cutoff frequencies of the corresponding propagating modes in the waveguide. We find the distribution of the electromagnetic field in the modes and calculate their damping rate due to a finite conductivity of the walls. The contribution of the trapped modes to the longitudinal impedance is calculated.

  17. HELIOSPHERIC ASYMMETRIES AND 2-3 kHz RADIO EMISSION UNDER STRONG INTERSTELLAR MAGNETIC FIELD CONDITIONS

    SciTech Connect

    Pogorelov, Nikolai V.; Heerikhuisen, Jacob; Zank, Gary P.; Mitchell, Jeremy J.; Cairns, Iver H.

    2009-04-10

    We discuss the asymmetry of the major heliospheric discontinuities obtained from the analysis of three-dimensional modeling of the solar wind interaction with the local interstellar medium (LISM). The flow of charged particles is governed by the ideal MHD equations and the transport of neutral particles is described by the Boltzmann equation. The emphasis is on the asymmetries of the termination shock (TS) and the heliopause under the combined action of the interstellar and interplanetary magnetic fields (ISMF and IMF) in the presence of neutral hydrogen atoms. It is shown that an ISMF of a strength greater than 4 {mu}G can account for the 10 AU difference in the TS heliocentric distances observed by the Voyager 1 and Voyager 2 spacecraft. We analyze the deflection of neutral hydrogen flow from its original direction in the unperturbed LISM and conclude that it remains within the range measured in the SOHO SWAN experiment. The impact is analyzed of a strong ISMF on the 2-3 kHz radio emission observed by the Voyager spacecraft, using new estimates of the radio emission conditions.

  18. Repeated intravenous cocaine experience: development and escalation of pre-drug anticipatory 50-kHz ultrasonic vocalizations in rats.

    PubMed

    Ma, Sean T; Maier, Esther Y; Ahrens, Allison M; Schallert, Timothy; Duvauchelle, Christine L

    2010-09-01

    Ultrasonic vocalization (USV) in the 50-kHz range occurs in rats immediately upon first-time exposure to cocaine or amphetamine, and rapidly increases with repetitive drug exposure at the same dose. This sensitized positive-affect response to these drugs of abuse is persistent in that the peak level of USVs again appears when the drug is reintroduced after several weeks of drug discontinuation. The present study explored whether with enough experience USVs might be elicited, and gradually escalate, in anticipation of impending drug delivery. Rats were trained to self-administer (SA) cocaine intravenously by lever pressing 5 days per week for 4 weeks. Yoked rats received experimenter-delivered cocaine matching that of SA rats. USVs and locomotor activity were recorded during each 10-min period prior to 60-min drug access sessions. Extinction trials in which drug access was denied were then carried out over an additional 4-week period. After about a week of cocaine experience, both the SA and yoked groups began to progressively increase USVs when placed in an environment that predicted forthcoming drug exposure. Extinction of anticipatory calls and locomotion occurred over days after drug access ended. USVs may be a useful model for specifically investigating the neural basis of drug anticipation and aid in developing and assessing new addiction treatment strategies for reducing craving and relapse.

  19. 48 CFR 49.303 - Procedure after discontinuing vouchers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Procedure after discontinuing vouchers. 49.303 Section 49.303 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for...

  20. 48 CFR 49.302 - Discontinuance of vouchers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Discontinuance of vouchers. 49.302 Section 49.302 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Cost-Reimbursement Contracts Terminated...

  1. Derivative discontinuity with localized Hartree-Fock potential

    NASA Astrophysics Data System (ADS)

    Nazarov, V. U.; Vignale, G.

    2015-08-01

    The localized Hartree-Fock potential has proven to be a computationally efficient alternative to the optimized effective potential, preserving the numerical accuracy of the latter and respecting the exact properties of being self-interaction free and having the correct -1/r asymptotics. In this paper we extend the localized Hartree-Fock potential to fractional particle numbers and observe that it yields derivative discontinuities in the energy as required by the exact theory. The discontinuities are numerically close to those of the computationally more demanding Hartree-Fock method. Our potential enjoys a "direct-energy" property, whereby the energy of the system is given by the sum of the single-particle eigenvalues multiplied by the corresponding occupation numbers. The discontinuities c↑ and c↓ of the spin-components of the potential at integer particle numbers N↑ and N↓ satisfy the condition c↑N↑ + c↓N↓ = 0. Thus, joining the family of effective potentials which support a derivative discontinuity, but being considerably easier to implement, the localized Hartree-Fock potential becomes a powerful tool in the broad area of applications in which the fundamental gap is an issue.

  2. 14 CFR 170.25 - LORAN-C discontinuance criteria.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false LORAN-C discontinuance criteria. 170.25 Section 170.25 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... costs (PVCM) of the LORAN-C approach exceed the present value of its remaining life-cycle benefits...

  3. 14 CFR 170.15 - ATCT discontinuance criteria.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false ATCT discontinuance criteria. 170.15 Section 170.15 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... termination costs (CMPV) of the ATCT exceed the present value of its remaining life-cycle benefits (BPV):...

  4. The Age of Discontinuity; Guidelines to Our Changing Society.

    ERIC Educational Resources Information Center

    Drucker, Peter F.

    Concentrating on the social dimension of human experience and existence, this book probes certain profound changes occurring in contemporary technology, economy, society, politics, and education. The author discusses four major discontinuities: (1) the impact of the new technology on the industrial structure; (2) the shift from an "international…

  5. Kinetic theory and turbulent discontinuities. [shock tube flow

    NASA Technical Reports Server (NTRS)

    Johnson, J. A., III; I, L.; Li, Y.; Ramaian, R.; Santigo, J. P.

    1981-01-01

    Shock tube discontinuities were used to test and extend a kinetic theory of turbulence. In shock wave and contact surface fluctuations, coherent phenomena were found which provide new support for the microscopic nonempirical approach to turbulent systems, especially those with boundary layer-like instabilities.

  6. 38 CFR 21.9630 - Suspension or discontinuance of payments.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2014-07-01 2014-07-01 false Suspension or discontinuance of payments. 21.9630 Section 21.9630 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) VOCATIONAL REHABILITATION AND EDUCATION Post-9/11 GI Bill...

  7. 38 CFR 21.9630 - Suspension or discontinuance of payments.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Suspension or discontinuance of payments. 21.9630 Section 21.9630 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) VOCATIONAL REHABILITATION AND EDUCATION Post-9/11 GI Bill...

  8. 38 CFR 21.9630 - Suspension or discontinuance of payments.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2011-07-01 2011-07-01 false Suspension or discontinuance of payments. 21.9630 Section 21.9630 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) VOCATIONAL REHABILITATION AND EDUCATION Post-9/11 GI Bill...

  9. 38 CFR 21.9630 - Suspension or discontinuance of payments.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2012-07-01 2012-07-01 false Suspension or discontinuance of payments. 21.9630 Section 21.9630 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) VOCATIONAL REHABILITATION AND EDUCATION Post-9/11 GI Bill...

  10. 38 CFR 21.9630 - Suspension or discontinuance of payments.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2013-07-01 2013-07-01 false Suspension or discontinuance of payments. 21.9630 Section 21.9630 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) VOCATIONAL REHABILITATION AND EDUCATION Post-9/11 GI Bill...

  11. Boston Naming Test Discontinuation Rule: "Rigorous" versus "Lenient" Interpretations.

    ERIC Educational Resources Information Center

    Ferman, Tanis J.; Ivnik, Robert J.; Lucas, John A.

    1998-01-01

    Two interpretations of the Boston Naming Test (BNT) (E. Kaplan, H. Goodglass, and S. Weintraub, 1983) discontinuation rule of six consecutive failures were found in BNT use with 655 normal older adults and 140 people with Alzheimer's disease. Differences between lenient and rigorous interpretations of responses could have impact on…

  12. Effect of motion discontinuities on discrimination of periodic trajectories.

    PubMed

    Wilson, Hugh R; Fung, Jeffrey

    2016-01-01

    Many biologically important motions are described by periodic trajectories. Radial frequency (RF) trajectories are one example, in which the motion of a difference of Gaussians (DOG) target moves along a path described by a sinusoidal deviation of the radius from a perfect circle (Or, Thabet, Wilkinson, & Wilson, 2011). Here we explore the hypothesis that visual processing of RF trajectories involves global spatio-temporal processes that are disrupted by motion discontinuity. To test this hypothesis, RF trajectories were used that interspersed smooth, continuous motion with three or four discontinuous jumps to other portions of the trajectory. These jumps were arranged so that the entire trajectory was traversed in the same amount of time as in the continuous motion control condition. The motion discontinuities increased thresholds by a factor of approximately 2.1 relative to continuous motion. This result provides support for global spatio-temporal processing of RF motion trajectories. Comparison with previous results suggests that motion discontinuities erase memory for earlier parts of the trajectory, thereby causing thresholds to be based on only the final segment viewed. Finally, it is shown that RF trajectories obey the 1/3 power law characteristic of biological motion.

  13. Fracture criteria for discontinuously reinforced metal matrix composites

    NASA Technical Reports Server (NTRS)

    Rack, H. J.; Goree, J. G.; Albritton, J.; Ratnarparkhi, P.

    1988-01-01

    The effect of sample configuration on the details of initial crack propagation in discontinuously whisker reinforced aluminum metal matrix composites was investigated. Care was taken to allow direct comparison of fracture toughness values utilizing differing sample configurations and orientations, holding all materials variables constant, e.g., extrusion ration, heat treatment, and chemistry.

  14. 77 FR 20988 - Discontinuance of Form CO in Registration Practices

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-09

    ... From the Federal Register Online via the Government Publishing Office LIBRARY OF CONGRESS Copyright Office 37 CFR Parts 201 and 202 Discontinuance of Form CO in Registration Practices Correction In rule document 2012-7429 appearing on pages 18705-18707 in the issue of March 28, 2012, make...

  15. Remedial Education and Student Achievement: A Regression-Discontinuity Analysis.

    ERIC Educational Resources Information Center

    Jacob, Brian A.; Lefgren, Lars

    This study used a regression discontinuity design to examine the causal effect of summer school and grade retention on student achievement. In 1996, the Chicago Public Schools instituted an accountability policy that tied summer school attendance and promotional decisions to performance on standardized tests, which created a highly non-linear…

  16. 38 CFR 8.17 - Discontinuance of premium waiver.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SERVICE LIFE INSURANCE Premium Waivers and Total Disability § 8.17 Discontinuance of premium waiver. (a... premiums shall cease as of the date of such finding, and the insurance may be continued by payment of..., and if such premium was not paid within 31 days after the due date, the insurance lapsed. (c) If...

  17. Regression Discontinuity Designs with Multiple Rating-Score Variables

    ERIC Educational Resources Information Center

    Reardon, Sean F.; Robinson, Joseph P.

    2012-01-01

    In the absence of a randomized control trial, regression discontinuity (RD) designs can produce plausible estimates of the treatment effect on an outcome for individuals near a cutoff score. In the standard RD design, individuals with rating scores higher than some exogenously determined cutoff score are assigned to one treatment condition; those…

  18. Reversible brain inactivation induces discontinuous gas exchange in cockroaches.

    PubMed

    Matthews, Philip G D; White, Craig R

    2013-06-01

    Many insects at rest breathe discontinuously, alternating between brief bouts of gas exchange and extended periods of breath-holding. The association between discontinuous gas exchange cycles (DGCs) and inactivity has long been recognised, leading to speculation that DGCs lie at one end of a continuum of gas exchange patterns, from continuous to discontinuous, linked to metabolic rate (MR). However, the neural hypothesis posits that it is the downregulation of brain activity and a change in the neural control of gas exchange, rather than low MR per se, which is responsible for the emergence of DGCs during inactivity. To test this, Nauphoeta cinerea cockroaches had their brains inactivated by applying a Peltier-chilled cold probe to the head. Once brain temperature fell to 8°C, cockroaches switched from a continuous to a discontinuous breathing pattern. Re-warming the brain abolished the DGC and re-established a continuous breathing pattern. Chilling the brain did not significantly reduce the cockroaches' MR and there was no association between the gas exchange pattern displayed by the insect and its MR. This demonstrates that DGCs can arise due to a decrease in brain activity and a change in the underlying regulation of gas exchange, and are not necessarily a simple consequence of low respiratory demand.

  19. Fracture criteria for discontinuously reinforced metal matrix composites

    NASA Technical Reports Server (NTRS)

    Rack, H. J.; Goree, J. G.; Albritton, J.; Ratnaparkhi, P.

    1988-01-01

    Summarized is the progress achieved during the period September 16, 1987 to August 15, l988 on NASA Grant NAG1-724, Fracture Criteria for Discontinuously Reinforced Metal Matrix Composites. Appended are copies of three manuscripts prepared under NASA funding during the performance period.

  20. Dialogic Reverberations: Police, Domestic Abuse, and the Discontinuance of Cases

    ERIC Educational Resources Information Center

    Lea, Susan J.; Lynn, Nick

    2012-01-01

    This study investigated the social construction of domestic abuse by police officers, specifically in the context of arguments presented to the prosecutor for a decision on whether to proceed with or discontinue the case. Nineteen police files were examined with a particular focus on the MG3, the "Report to Crown Prosecutors for Charging…

  1. Regression Discontinuity Design in Gifted and Talented Education Research

    ERIC Educational Resources Information Center

    Matthews, Michael S.; Peters, Scott J.; Housand, Angela M.

    2012-01-01

    This Methodological Brief introduces the reader to the regression discontinuity design (RDD), which is a method that when used correctly can yield estimates of research treatment effects that are equivalent to those obtained through randomized control trials and can therefore be used to infer causality. However, RDD does not require the random…

  2. A Bayesian Nonparametric Causal Model for Regression Discontinuity Designs

    ERIC Educational Resources Information Center

    Karabatsos, George; Walker, Stephen G.

    2013-01-01

    The regression discontinuity (RD) design (Thistlewaite & Campbell, 1960; Cook, 2008) provides a framework to identify and estimate causal effects from a non-randomized design. Each subject of a RD design is assigned to the treatment (versus assignment to a non-treatment) whenever her/his observed value of the assignment variable equals or…

  3. Can eculizumab be discontinued in aHUS?

    PubMed Central

    Sahutoglu, Tuncay; Basturk, Taner; Sakaci, Tamer; Koc, Yener; Ahbap, Elbis; Sevinc, Mustafa; Kara, Ekrem; Akgol, Cuneyt; Caglayan, Feyza Bayraktar; Unsal, Abdulkadir; Daha, Mohamed R.

    2016-01-01

    Abstract Background: The management of atypical hemolytic uremic syndrome (aHUS) has evolved into better control of thrombotic microangiopathy (TMA) and recovery of renal functions since the recent introduction of the terminal complement cascade blocker, eculizumab, into clinical use. Better characterization of genotype–phenotype relations has become possible with genetic and clinical studies. However, these advances brought up some important issues, such as the possibility and timing of discontinuation of eculizumab and strategy of follow-up that need to be enlightened. Case Summary: One of our aHUS cases with a novel complement factor H mutation, who developed unusual laboratory findings (thrombocytopenia and mild creatinine elevation without other features of TMA) following discontinuation of eculizumab was presented. Literature and case reports relevant to discontinuation of eculizumab in aHUS patients were reviewed. Conclusion: Limited experience suggests that the risk of recurrence of TMA following discontinuation of eculizumab is relatively low for patients with MCP mutations, homozygous CFHR3/R1 deletions, anti-CFH antibodies, CFI mutations, and no identifiable mutations, whereas there is a major risk for patients with CFH mutations. Early detection of TMA recurrence and prompt retreatment with eculizumab seem to be efficient in controlling of TMA and restoration of kidney functions. PMID:27495036

  4. Derivative discontinuity with localized Hartree-Fock potential.

    PubMed

    Nazarov, V U; Vignale, G

    2015-08-14

    The localized Hartree-Fock potential has proven to be a computationally efficient alternative to the optimized effective potential, preserving the numerical accuracy of the latter and respecting the exact properties of being self-interaction free and having the correct -1/r asymptotics. In this paper we extend the localized Hartree-Fock potential to fractional particle numbers and observe that it yields derivative discontinuities in the energy as required by the exact theory. The discontinuities are numerically close to those of the computationally more demanding Hartree-Fock method. Our potential enjoys a "direct-energy" property, whereby the energy of the system is given by the sum of the single-particle eigenvalues multiplied by the corresponding occupation numbers. The discontinuities c↑ and c↓ of the spin-components of the potential at integer particle numbers N↑ and N↓ satisfy the condition c↑N↑ + c↓N↓ = 0. Thus, joining the family of effective potentials which support a derivative discontinuity, but being considerably easier to implement, the localized Hartree-Fock potential becomes a powerful tool in the broad area of applications in which the fundamental gap is an issue. PMID:26277131

  5. Sound propagation in a refracting atmosphere above an impedance discontinuity

    NASA Astrophysics Data System (ADS)

    Taherzadeh, Shahram; Harrop, Nick

    2002-11-01

    de Jongs formulation of sound propagation above a ground with a single impedance change has been extended to include effects of a refracting atmosphere and atmospheric turbulence. The theory is compared with a numerical algorithm based on a hybrid Boundary Integral Equation/Fast Field Program developed for predicting the propagation of sound in a refracting atmosphere above an uneven, discontinuous terrain. By using the analogy of sound diffraction over curved surfaces to atmospheric refraction over flat ground surfaces, the effect of temperature and wind velocity gradients in the presence of flat ground surfaces can be studied. Measurements of the excess attenuation of sound from a point source over a mixed impedance curved surface are carried out in an anechoic chamber as well as outdoor measurements over a tarmac-grass discontinuity. These measurements are compared with predictions based on the extended de Jong theory and the hybrid BIE/FFP algorithm in the nonturbulent case. Results show that where there is a single discontinuity between acoustically hard and finite impedance surfaces both models are found to give satisfactory agreement with measured data except when the discontinuity is midway between the source and the detector.

  6. Reciprocity principle for scattered fields from discontinuities in waveguides.

    PubMed

    Pau, Annamaria; Capecchi, Danilo; Vestroni, Fabrizio

    2015-01-01

    This study investigates the scattering of guided waves from a discontinuity exploiting the principle of reciprocity in elastodynamics, written in a form that applies to waveguides. The coefficients of reflection and transmission for an arbitrary mode can be derived as long as the principle of reciprocity is satisfied at the discontinuity. Two elastodynamic states are related by the reciprocity. One is the response of the waveguide in the presence of the discontinuity, with the scattered fields expressed as a superposition of wave modes. The other state is the response of the waveguide in the absence of the discontinuity oscillating according to an arbitrary mode. The semi-analytical finite element method is applied to derive the needed dispersion relation and wave mode shapes. An application to a solid cylinder with a symmetric double change of cross-section is presented. This model is assumed to be representative of a damaged rod. The coefficients of reflection and transmission of longitudinal waves are investigated for selected values of notch length and varying depth.

  7. Derivative discontinuity with localized Hartree-Fock potential

    SciTech Connect

    Nazarov, V. U.; Vignale, G.

    2015-08-14

    The localized Hartree-Fock potential has proven to be a computationally efficient alternative to the optimized effective potential, preserving the numerical accuracy of the latter and respecting the exact properties of being self-interaction free and having the correct −1/r asymptotics. In this paper we extend the localized Hartree-Fock potential to fractional particle numbers and observe that it yields derivative discontinuities in the energy as required by the exact theory. The discontinuities are numerically close to those of the computationally more demanding Hartree-Fock method. Our potential enjoys a “direct-energy” property, whereby the energy of the system is given by the sum of the single-particle eigenvalues multiplied by the corresponding occupation numbers. The discontinuities c{sub ↑} and c{sub ↓} of the spin-components of the potential at integer particle numbers N{sub ↑} and N{sub ↓} satisfy the condition c{sub ↑}N{sub ↑} + c{sub ↓}N{sub ↓} = 0. Thus, joining the family of effective potentials which support a derivative discontinuity, but being considerably easier to implement, the localized Hartree-Fock potential becomes a powerful tool in the broad area of applications in which the fundamental gap is an issue.

  8. The Nature and Determinants of Intranet Discontinuance after Mandatory Adoption

    ERIC Educational Resources Information Center

    Cho, Inho

    2008-01-01

    This research examines post-adoption behavior (discontinuance versus continuance) with the context of Intranet use. Multiple theories are used as theoretical frameworks to extend information communication technology research to the case of post-adoption behavior. Three research questions and six sets of hypotheses are formulated to distinguish…

  9. Effect of motion discontinuities on discrimination of periodic trajectories.

    PubMed

    Wilson, Hugh R; Fung, Jeffrey

    2016-01-01

    Many biologically important motions are described by periodic trajectories. Radial frequency (RF) trajectories are one example, in which the motion of a difference of Gaussians (DOG) target moves along a path described by a sinusoidal deviation of the radius from a perfect circle (Or, Thabet, Wilkinson, & Wilson, 2011). Here we explore the hypothesis that visual processing of RF trajectories involves global spatio-temporal processes that are disrupted by motion discontinuity. To test this hypothesis, RF trajectories were used that interspersed smooth, continuous motion with three or four discontinuous jumps to other portions of the trajectory. These jumps were arranged so that the entire trajectory was traversed in the same amount of time as in the continuous motion control condition. The motion discontinuities increased thresholds by a factor of approximately 2.1 relative to continuous motion. This result provides support for global spatio-temporal processing of RF motion trajectories. Comparison with previous results suggests that motion discontinuities erase memory for earlier parts of the trajectory, thereby causing thresholds to be based on only the final segment viewed. Finally, it is shown that RF trajectories obey the 1/3 power law characteristic of biological motion. PMID:26891831

  10. Bilateral filter regularized accelerated Demons for improved discontinuity preserving registration.

    PubMed

    Demirović, D; Šerifović-Trbalić, A; Prljača, N; Cattin, Ph C

    2015-03-01

    The classical accelerated Demons algorithm uses Gaussian smoothing to penalize oscillatory motion in the displacement fields during registration. This well known method uses the L2 norm for regularization. Whereas the L2 norm is known for producing well behaving smooth deformation fields it cannot properly deal with discontinuities often seen in the deformation field as the regularizer cannot differentiate between discontinuities and smooth part of motion field. In this paper we propose replacement the Gaussian filter of the accelerated Demons with a bilateral filter. In contrast the bilateral filter not only uses information from displacement field but also from the image intensities. In this way we can smooth the motion field depending on image content as opposed to the classical Gaussian filtering. By proper adjustment of two tunable parameters one can obtain more realistic deformations in a case of discontinuity. The proposed approach was tested on 2D and 3D datasets and showed significant improvements in the Target Registration Error (TRE) for the well known POPI dataset. Despite the increased computational complexity, the improved registration result is justified in particular abdominal data sets where discontinuities often appear due to sliding organ motion. PMID:25541494

  11. Premature Discontinuation in Adult Psychotherapy: A Meta-Analysis

    ERIC Educational Resources Information Center

    Swift, Joshua K.; Greenberg, Roger P.

    2012-01-01

    Objective: Premature discontinuation from therapy is a widespread problem that impedes the delivery of otherwise effective psychological interventions. The most recent comprehensive review found an average dropout rate of 47% across 125 studies (Wierzbicki & Pekarik, 1993); however, given a number of changes in the field over the past 2 decades,…

  12. Continuities and Discontinuities in Psychopathology between Childhood and Adult Life

    ERIC Educational Resources Information Center

    Rutter, Michael; Kim-Cohen, Julia; Maughan, Barbara

    2006-01-01

    The possible mechanisms involved in continuities and discontinuities in psychopathology between childhood and adult life are considered in relation to the findings from systematic, prospective, long-term longitudinal studies. Findings on schizophrenia, neurodevelopmental disorders, emotional disturbances, antisocial behaviour and substance abuse…

  13. 14 CFR Section 16 - Objective Classification-Discontinued Operations

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Objective Classification-Discontinued Operations Section 16 Section 16 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION... AIR CARRIERS Profit and Loss Classification Section 16 Objective...

  14. MEDICATION USE FOLLOWING BARIATRIC SURGERY: FACTORS ASSOCIATED WITH EARLY DISCONTINUATION

    PubMed Central

    Kennedy, Amy L.; Nelson, Tracy; Pettine, Stefan; Miller, Benjamin F.; Hamilton, Karyn L.

    2013-01-01

    Background Medication discontinuation is a common result of bariatric surgery. The influence of individual patient characteristics and surgical outcomes on overall and specific medication discontinuation is not well understood. The purpose of the current study was to assess changes in medication use and identify individual characteristics and surgical outcomes associated with medication discontinuation among bariatric patients. Methods The patients included in the current study received bariatric surgery from the Northern Colorado Surgical Associates of Fort Collins, Colorado between October 2007 and September 2010. Demographic, weight, health, and medication data from 400 patients with at least one 6 or 12 month post-operative appointment were extracted from the Bariatric Outcome Longitudinal Database (BOLD). Multivariate regression analyses were used to investigate how patient factors affect total medication use over time, use of medications grouped by co-morbidity postoperatively, and use of specific medication classes post-operatively. Results Baseline co-morbidities, particularly type 2 diabetes (T2DM), male sex, and Roux-en-Y gastric bypass surgery were significantly associated with decreased total medication use following surgery. Weight loss, systemic disease, sex, baseline co-morbidities, surgical complications, and race were significantly associated with continued use of specific medications following surgery. Conclusions Bariatric surgery can help patients with certain characteristics discontinue medications, but is not effective for all patients. Baseline health, sex, race, bariatric procedure, surgical complications, and post-operative weight loss may affect how bariatric patients’ medication use changes pre-operatively to post-operatively. PMID:24234778

  15. Stability of discontinuity structures described by a generalized KdV-Burgers equation

    NASA Astrophysics Data System (ADS)

    Chugainova, A. P.; Shargatov, V. A.

    2016-02-01

    The stability of discontinuities representing solutions of a model generalized KdV-Burgers equation with a nonmonotone potential of the form φ( u) = u 4- u 2 is analyzed. Among these solutions, there are ones corresponding to special discontinuities. A discontinuity is called special if its structure represents a heteroclinic phase curve joining two saddle-type special points (of which one is the state ahead of the discontinuity and the other is the state behind the discontinuity).The spectral (linear) stability of the structure of special discontinuities was previously studied. It was shown that only a special discontinuity with a monotone structure is stable, whereas special discontinuities with a nonmonotone structure are unstable. In this paper, the spectral stability of nonspecial discontinuities is investigated. The structure of a nonspecial discontinuity represents a phase curve joining two special points: a saddle (the state ahead of the discontinuity) and a focus or node (the state behind the discontinuity). The set of nonspecial discontinuities is examined depending on the dispersion and dissipation parameters. A set of stable nonspecial discontinuities is found.

  16. Seismic Structure of the Mantle Discontinuities beneath Northeast Asia

    NASA Astrophysics Data System (ADS)

    Li, J.; WANG, X.; Guo, G.

    2015-12-01

    Seismic structure of the upper mantle discontinuities is important for understanding the thermal structure, composition of the mantle, and scales of mantle circulation as well. Northeast Asia is located at the front edge of the subducting Pacific slab, which is an ideal place to study the interaction between the upper mantle discontinuities and the subducting slab. Seismic tomography images have revealed different morphologies of slabs in the deep mantle. A prominent stagnant slab is trapped in the MTZ beneath Japan Sea and southern Kuril trench; while the slabs penetrate into the lower mantle directly beneath the northern Kuril and southern Izu-Bonin trench. Due to the sparse distribution of seismic stations in the sea, investigation of the deep mantle structure beneath the broad sea regions is very limited. In this study, we applied the multiple-ScS reverberations analysis to waveforms recorded by the Chinese Regional Seismic Network and F-net. We took advantage of the dense distribution of stations and spatial clusters of intermediate and deep earthquakes occurred beneath Okhotsk Sea, Russia and Northeast China, and conducted a common-reflection-point (CRP) stacking to the data, that allows us to map the topography of the 410-km and 660-km discontinuities beneath Japan Sea, Kuril, and adjacent regions in detail. We also compiled previous results obtained from the high frequency receiver function and S-to-P converted wave analyzes, and compared the results in the overlapping island or continental margin regions. The comparison shows that the array stacking technique to long-period signals is effective in extracting the robust features of the upper mantle discontinuities. It can be used not only as a complimentary method to short-period waveform analysis, but also as an independent way which can be applied to regions with limited station coverage. This is the first time to show systematically a complete view of the topography of the 410-km and 660-km

  17. A review of the management of antidepressant discontinuation symptoms

    PubMed Central

    Wilson, Emma; Lader, Malcolm

    2015-01-01

    Strong evidence supports the existence of a discontinuation syndrome following the withdrawal of antidepressant medication, particularly second-generation antidepressants. The syndrome is a common phenomenon and guidance as to best avoid the symptoms is essential for both practitioners and patients. The current study reviewed the available literature on the best methods of discontinuation for antidepressants in order to avoid or prevent the occurrence of any unpleasant side effects associated with antidepressant withdrawal. Accordingly, an electronic search of the PubMed/MedLine database and Google Scholar was conducted to find relevant literature published within the last 10 years. From this, 18 related articles were identified; five clinical studies, one case series, one consensus panel’s recommendations and 11 literature reviews. Of the articles reviewed there is a general consensus as to tapering the drug slowly over a period of weeks or months. Also, in those patients who experience severe symptoms the drug should be reinstated and discontinued more gradually. The discontinuation syndrome does not occur as frequently or severely with longer-acting agents such as fluoxetine and therefore it is recommended that switching to this drug prior to withdrawal may be advisable. The articles reviewed also emphasize the need for patient education and reassurance throughout the discontinuation process. One in particular adds that cognitive behavioural therapy may be a useful tool in easing the patients’ distress. However, this review highlights the lack of controlled data to support the available guidelines. Furthermore, the guidance which is available is somewhat conflicting. Research approaches should address this issue as well as develop appropriate methods of withdrawal for specific drugs. PMID:26834969

  18. Analysis of factors associated with maintenance discontinuation in implant patients.

    PubMed

    Arai, K; Takeda, Y; Mori, Y; Terauchi, R; Furumori, T; Tanaka, S; Miyake, T; Baba, S; Kawazoe, T

    2015-01-01

    Maintenance following implant treatment is essential to ensure long-term stability. Accordingly, the objective of this study was to investigate the factors leading patients to discontinue maintenance following implant treatment. Among the 729 patients that underwent implantation at the Department of Oral Implantology, Osaka Dental University Hospital from January 2008 to December 2012, 41 patients were excluded from the study. Exclusion criteria comprised patients without a superstructure attachment, those who only underwent maxillary sinus floor augmentation procedures and those who discontinued visiting the hospital prior to superstructure attachment. Treatment was discontinued in 181 patients. The rate of discontinuation was 26.6 %. The odds ratio (OR) in the adjustment model was 1.552 (95 % CI 1.078-2.236) in males when compared with females. When compared with those who were 30-64 years old, the OR was 5.818 (95 % CI 3.017-11.220) in those 29 years old or younger and 1.561 (95 % CI 1.021-2.386) in those 65 years old or older. Moreover, when compared with those with a O'Leary's Plaque Control Record of all teeth and superstructures (PCR) level of 20 % or less following superstructure attachment, the OR was 2.113 (95 % CI 1.471-3.035) in those with a PCR level of 20 % or more following superstructure attachment. It is highly important to decrease maintenance discontinuation, especially in patients aged 29 years old or younger with a PCR level of 20 % or more following superstructure attachment. Moreover, a support system must be developed to enable patients with difficulties visiting the hospital to continue their maintenance program.

  19. Error Analysis for Discontinuous Galerkin Method for Parabolic Problems

    NASA Technical Reports Server (NTRS)

    Kaneko, Hideaki

    2004-01-01

    In the proposal, the following three objectives are stated: (1) A p-version of the discontinuous Galerkin method for a one dimensional parabolic problem will be established. It should be recalled that the h-version in space was used for the discontinuous Galerkin method. An a priori error estimate as well as a posteriori estimate of this p-finite element discontinuous Galerkin method will be given. (2) The parameter alpha that describes the behavior double vertical line u(sub t)(t) double vertical line 2 was computed exactly. This was made feasible because of the explicitly specified initial condition. For practical heat transfer problems, the initial condition may have to be approximated. Also, if the parabolic problem is proposed on a multi-dimensional region, the parameter alpha, for most cases, would be difficult to compute exactly even in the case that the initial condition is known exactly. The second objective of this proposed research is to establish a method to estimate this parameter. This will be done by computing two discontinuous Galerkin approximate solutions at two different time steps starting from the initial time and use them to derive alpha. (3) The third objective is to consider the heat transfer problem over a two dimensional thin plate. The technique developed by Vogelius and Babuska will be used to establish a discontinuous Galerkin method in which the p-element will be used for through thickness approximation. This h-p finite element approach, that results in a dimensional reduction method, was used for elliptic problems, but the application appears new for the parabolic problem. The dimension reduction method will be discussed together with the time discretization method.

  20. Outcomes of a school-based intervention (RESCATE) to improve physical activity patterns in Mexican children aged 8-10 years.

    PubMed

    Colín-Ramírez, E; Castillo-Martínez, L; Orea-Tejeda, A; Vergara-Castañeda, A; Keirns-Davis, C; Villa-Romero, A

    2010-12-01

    The aim of this study was to evaluate the impact of an intervention program on the patterns of physical activity in 8- to 10-year-old Mexican children from lower socioeconomic status. This study performed a randomized controlled field trial in 498 children aged 8-10 years from 10 public schools of low socioeconomic status in Mexico City. Schools were randomly assigned to intervention (n = 5) or control (n = 5) groups and followed up during 12 months. Physical and sedentary activities were assessed at the beginning of the program and after 6 and 12 months. At the end of follow-up, there was a significant increase in the performance of moderate physical activity (MPA) among children in intervention group who had not performed MPA at baseline any day of the week (40%, P = 0.04) but not in the control group (8%, P = not significant). The intervention group also showed a significant reduction in the proportion of children who spent more than 3 hours a day playing video games (from 23 to 13%, P = 0.01), while control group did not show significant changes. Given these findings, we conclude that intervention was able to modify positively physical activity and reduce time spent on such sedentary activities as video games among those at highest risk studied children.

  1. Dissociation of molecular chlorine in a Coulomb explosion: Potential curves, bound states, and deviation from Coulombic behavior for Cln+2 (n=2,3,4,6,8,10)

    NASA Astrophysics Data System (ADS)

    Wright, J. S.; Dilabio, G. A.; Matusek, D. R.; Corkum, P. B.; Ivanov, M. Yu.; Ellert, Ch.; Buenker, R. J.; Alekseyev, A. B.; Hirsch, G.

    1999-06-01

    Highly charged molecular ions are generated in Coulomb explosion experiments involving multielectron dissociative ionization, but little is known about the precise mechanisms involved in their formation. To help improve the understanding of such experiments, potential energy curves are calculated in this paper for diatomic chlorine (Cl2) and its ions Cln+2, where n=1,2,3,4,6,8,10. Bound vibrational states are obtained in three low-lying electronic states for Cl2+2 and one state for Cl3+2. Vertical excitation energies are given for stepwise excitations up to Cl10+2. For all the ions examined there is a significant energy defect (Δ) from the corresponding Coulomb potential, in one case reaching magnitudes of over 20 eV. We analyze the origin of these energy defects in terms of residual chemical bonding, and discuss the contribution of strongly bonding configurations at short internuclear distance. Finally, we present a simple physical model which describes the qualitative behavior of Δ(R,Q).

  2. Effects on atmospherics at 6 kHz and 9 kHz recorded at Tripura during the India-Pakistan Border earthquake

    NASA Astrophysics Data System (ADS)

    de, S. S.; de, B. K.; Bandyopadhyay, B.; Paul, S.; Haldar, D. K.; Bhowmick, A.; Barui, S.; Ali, R.

    2010-04-01

    The outcome of the results of some analyses of electromagnetic emissions recorded by VLF receivers at 6 kHz and 9 kHz over Agartala, Tripura, the North-Eastern state of India (Lat. 23° N, Long. 91.4° E) during the large earthquake at Muzaffarabad (Lat. 34.53° N, Long. 73.58° E) at Kashmir under Pakistan have been presented here. Spiky variations in integrated field intensity of atmospherics (IFIA) at 6 and 9 kHz have been observed 10 days prior (from midnight of 28 September 2005) to the day of occurrence of the earthquake on 8 October 2005 and the effect continued, decayed gradually and eventually ceased on 16 October 2005. The spikes distinctly superimposed on the ambient level with mutual separation of 2-5 min. Occurrence number of spikes per hour and total duration of their occurrence have been found remarkably high on the day of occurrence of the earthquake. The spike heights are higher at 6 kHz than at 9 kHz. The results have been explained on the basis of generation of electromagnetic radiation associated with fracture of rocks, their subsequent penetration into the Earth's atmosphere and finally their propagation between Earth-ionosphere waveguide. The present observation shows that VLF anomaly is well-confined between 6 and 9 kHz.

  3. Analgesic effects of transcutaneous electrical nerve stimulation and interferential current on experimental ischemic pain models: frequencies of 50 hz and 100 hz.

    PubMed

    Bae, Young-Hyeon; Lee, Suk Min

    2014-12-01

    [Purpose] This study compared the analgesic effects of transcutaneous electrical nerve stimulation (TENS) and interferential currents (IFC) on induced ischemic pain in healthy volunteers. [Subjects] The subjects were 36 volunteers (18 male, 18 female) without known pathology that could cause pain. Their mean age was 24.5±2.2 years. [Methods] A single-blind and parallel-group method was used. Subjects were randomly allocated to receive each 50 Hz TENS, 50 Hz IFC, 100 Hz TENS, and 100 Hz IFC. This study experimentally induced ischemic pain in otherwise pain-free subjects using a modified version of the submaximal effort tourniquet technique. Subjects completed twelve cycles of the ischemic-induced pain test. The primary outcome measure was the change in self-reported of pain intensity during one of four possible treatments. [Results] There were significant effects for Time, which were attributed to a significant reduction in pain intensity for all groups. There were no significant effects for groups or group-time interaction. The 50 Hz IFC treatment was more comfortable than the other treatments in the present study, and it is likely to be better accepted and tolerated by patients. [Conclusion] We conclude that there were no differences in the analgesic effects of the four treatments under the present experimental conditions. The 50 Hz IFC treatment is more comfortable than the other treatments.

  4. Hearing thresholds of a harbor porpoise (Phocoena phocoena) for sweeps (1-2 kHz and 6-7 kHz bands) mimicking naval sonar signals.

    PubMed

    Kastelein, Ronald A; Hoek, Lean; de Jong, Christ A F

    2011-05-01

    The distance at which active naval sonar signals can be heard by harbor porpoises depends, among other factors, on the hearing thresholds of the species for those signals. Therefore the hearing sensitivity of a harbor porpoise was determined for 1 s up-sweep and down-sweep signals, mimicking mid-frequency and low-frequency active sonar sweeps (MFAS, 6-7 kHz band; LFAS, 1-2 kHz band). The 1-2 kHz sweeps were also tested with harmonics, as sonars sometimes produce these as byproducts of the fundamental signal. The hearing thresholds for up-sweeps and down-sweeps within each sweep pair were similar. The 50% detection threshold sound pressure levels (broadband, averaged over the signal duration) of the 1-2 kHz and 6-7 kHz sweeps were 75 and 67 dB re 1 μPa(2), respectively. Harmonic deformation of the 1-2 kHz sweeps reduced the threshold to 59 dB re 1 μPa(2). This study shows that the presence of harmonics in sonar signals can increase the detectability of a signal by harbor porpoises, and that tonal audiograms may not accurately predict the audibility of sweeps. LFAS systems, when designed to produce signals without harmonics, can operate at higher source levels than MFAS systems, at similar audibility distances for porpoises.

  5. 47 CFR 15.217 - Operation in the band 160-190 kHz.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Operation in the band 160-190 kHz. 15.217... Intentional Radiators Radiated Emission Limits, Additional Provisions § 15.217 Operation in the band 160-190 k... lead (if used) shall not exceed 15 meters. (c) All emissions below 160 kHz or above 190 kHz shall...

  6. 47 CFR 15.217 - Operation in the band 160-190 kHz.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Operation in the band 160-190 kHz. 15.217... Intentional Radiators Radiated Emission Limits, Additional Provisions § 15.217 Operation in the band 160-190 k... lead (if used) shall not exceed 15 meters. (c) All emissions below 160 kHz or above 190 kHz shall...

  7. 47 CFR 15.217 - Operation in the band 160-190 kHz.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Operation in the band 160-190 kHz. 15.217... Intentional Radiators Radiated Emission Limits, Additional Provisions § 15.217 Operation in the band 160-190 k... lead (if used) shall not exceed 15 meters. (c) All emissions below 160 kHz or above 190 kHz shall...

  8. 47 CFR 15.217 - Operation in the band 160-190 kHz.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Operation in the band 160-190 kHz. 15.217... Intentional Radiators Radiated Emission Limits, Additional Provisions § 15.217 Operation in the band 160-190 k... lead (if used) shall not exceed 15 meters. (c) All emissions below 160 kHz or above 190 kHz shall...

  9. 47 CFR 15.217 - Operation in the band 160-190 kHz.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Operation in the band 160-190 kHz. 15.217... Intentional Radiators Radiated Emission Limits, Additional Provisions § 15.217 Operation in the band 160-190 k... lead (if used) shall not exceed 15 meters. (c) All emissions below 160 kHz or above 190 kHz shall...

  10. Times to Discontinue Antidepressants Over 6 Months in Patients with Major Depressive Disorder

    PubMed Central

    Jung, Woo-Young; Jang, Sae-Heon; Jae, Young-Myo; Kong, Bo-Geum; Kim, Ho-Chan; Choe, Byeong-Moo; Kim, Jeong-Gee; Kim, Choong-Rak

    2016-01-01

    Objective The aim of the present study was to investigate differences in discontinuation time among antidepressants and total antidepressant discontinuation rate of patients with depression over a 6 month period in a naturalistic treatment setting. Methods We reviewed the medical records of 900 patients with major depressive disorder who were initially prescribed only one kind of antidepressant. The prescribed antidepressants and the reasons for discontinuation were surveyed at baseline and every 4 weeks during the 24 week study. We investigated the discontinuation rate and the mean time to discontinuation among six antidepressants groups. Results Mean and median overall discontinuation times were 13.8 and 12 weeks, respectively. Sertraline and escitalopram had longer discontinuation times than that of fluoxetine, and patients who used sertraline discontinued use significantly later than those taking mirtazapine. No differences in discontinuation rate were observed after 24 weeks among these antidepressants. About 73% of patients discontinued antidepressant treatment after 24 weeks. Conclusion Sertraline and escitalopram tended to have longer mean times to discontinuation, although no difference in discontinuation rate was detected between antidepressants after 24 weeks. About three-quarters of patients discontinued antidepressant maintenance therapy after 24 weeks. PMID:27482246

  11. Unintentional Discontinuation of Chronic Medications for Seniors in Nursing Homes

    PubMed Central

    Stall, Nathan M.; Fischer, Hadas D.; Wu, C. Fangyun; Bierman, Arlene S.; Brener, Stacey; Bronskill, Susan; Etchells, Edward; Fernandes, Olavo; Lau, Davina; Mamdani, Muhammad M.; Rochon, Paula; Urbach, David R.; Bell, Chaim M.

    2015-01-01

    Abstract Transitions of care leave patients vulnerable to the unintentional discontinuation of medications with proven efficacy for treating chronic diseases. Older adults residing in nursing homes may be especially susceptible to this preventable adverse event. The effect of large-scale policy changes on improving this practice is unknown. The objective of this study was to analyze the effect of a national medication reconciliation accreditation requirement for nursing homes on rates of unintentional medication discontinuation after hospital discharge. It was a population-based retrospective cohort study that used linked administrative records between 2003 and 2012 of all hospitalizations in Ontario, Canada. We identified nursing home residents aged ≥66 years who had continuous use of ≥1 of the 3 selected medications for chronic disease: levothyroxine, HMG-CoA reductase inhibitors (statins), and proton pump inhibitors (PPIs). In 2008 medication reconciliation became a required practice for accreditation of Canadian nursing homes. The main outcome measures included the proportion of patients who restarted the medication of interest after hospital discharge at 7 days. We also performed a time series analysis to examine the impact of the accreditation requirement on rates of unintentional medication discontinuation. The study included 113,088 adults aged ≥66 years who were nursing home residents, had an acute hospitalization, and were discharged alive to the same nursing home. Overall rates of discontinuation at 7-days after hospital discharge were highest in 2003–2004 for all nursing homes: 23.9% for thyroxine, 26.4% for statins, and 23.9% for PPIs. In most of the cases, these overall rates decreased annually and were lowest in 2011–2012: 4.0% for thyroxine, 10.6% for statins, and 8.3% for PPIs. The time series analysis found that nursing home accreditation did not significantly lower medication discontinuation rates for any of the 3 drug groups. From 2003

  12. Theoretical study of the structures and first hyperpolarizabilities of C60Cl n and Li@C60Cl n (n = 4, 6, 8, 10).

    PubMed

    Song, Yao-Dong; Wang, Liang; Wu, Li-Ming

    2016-06-01

    We recently reported (Song Y-D et al., 2016, J Mol Model 22:50) that doping with Li greatly affects the static first hyperpolarizability of C60Cl2. In this work, with a view to creating nonlinear optical materials with high thermodynamic stability and wide transparent regions, a series of Li@C60Cl n (n = 4, 6, 8, 10) were designed. The structures, electrostatic potentials, electronic structures, absorption spectra, and linear and nonlinear optical properties of C60Cl n and Li@C60Cl n were systematically investigated using density functional theory (DFT) methods. The results of our calculations indicated that the stability of these molecules decreases in the order Li@C60Cl10 > Li@C60Cl8 > Li@C60Cl6 > Li@C60Cl4. It is clear that the number of Cl atoms greatly influences the stability of Li@C60Cl n . Li@C60Cl n showed greater thermodynamic stability than Li@C60Cl2. We also investigated the first hyperpolarizabilities of Li@C60Cl n and found them to be 2973, 3640, 4307, and 2627 au for n = 4, 6, 8, and 10, respectively-higher than that of Li@C60Cl2. Finally, we noted that the transparent region could be modulated by increasing the number of Cl atoms: Li@C60Cl n possess wider transparent regions than that of Li@C60Cl2. We therefore believe that this study has highlighted an effective method for designing nonlinear optical materials with high thermodynamic stability and wide transparent regions. PMID:27188724

  13. Characterizing azimuthal anisotropy at the mid-lithospheric discontinuity in the Superior and Wyoming Cratons

    NASA Astrophysics Data System (ADS)

    Ford, H. A.; Long, M. D.; Wirth, E. A.

    2015-12-01

    The recent observation of a ubiquitous mid-lithospheric discontinuity (MLD) within tectonically stable Proterozoic- to Archean-aged lithosphere has led to questions about the formation of the MLD and the continental lithosphere. The MLD has been typically imaged as a drop in velocity from Sp receiver functions, but establishing a single mechanism for a global negative velocity gradient within stable continental lithosphere has proven difficult. One proposed mechanism, azimuthal anisotropy, has been suggested however, it is unclear how such anisotropy could produce a consistently negative phase in Sp receiver functions. More fundamentally, it is unclear how lithospheres with different tectonic histories would all have a boundary in anisotropy located at similar depths. To better understand the relationship between the MLD, anisotropy and tectonic history we have calculated radial and transverse component Ps receiver functions for seven permanent US Array stations within the Superior and Wyoming Cratons. The two cratons are similar in age and collided during the Trans-Hudson orogen at ~1.8 Ga, forming the core of present day Laurentia. The receiver functions were generated using a multi-taper cross correlation technique and events were limited to distances of 30 to 100°, and magnitudes greater than 5.8. Seismograms were inspected for data quality; receiver function results were binned as functions of back azimuth and epicentral distance. At stations DGMT, EGMT, LAO, and LKWY, a large amplitude negative phase is observed 8-10 seconds after the direct P arrival on the radial component. This arrival corresponds to a depth of approximately 80 to 100 km and is interpreted to be the MLD. Preliminary analysis of the transverse component finds significant energy within the same time window as the radial component MLD with changes in polarity observed in some instances. Further work is needed before the character of these polarity changes, and their associated anisotropy

  14. Influence of crystal characteristics on the shock sensitivities of cyclotrimethylene trinitramine, cyclotetramethylene tetranitramine, and 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazatetra-cyclo[5,5,0,03,1105,9]dodecane immersed in liquid

    NASA Astrophysics Data System (ADS)

    Li, Hongzhen; Xu, Rong; Kang, Bing; Li, Jinshan; Zhou, Xiaoqing; Zhang, Chaoyang; Nie, Fude

    2013-05-01

    The shock sensitivities of differently qualified cyclotrimethylene trinitramine (RDX), cyclotetramethylene tetranitramine(HMX), and 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazatetra-cyclo[5,5,0,03,1105,9]dodecane (CL-20) immersed in liquid were determined by the large-scale gap tests, for systemic discussion on the influences of crystal characteristics on them. As a result, it shows that (1) the immersion of crystals in liquid leads to an obvious sensitivity decrease; (2) for all three explosives, their shock sensitivities are lowered with increasing their crystal apparent densities or decreasing their particle sizes, and almost not affected by particle morphologies; (3) the crystal twins are readily formed for HMX and the most distinct factor influencing its shock sensitivities; (4) it is found that the crystal apparent density affects most obviously the shock sensitivities for RDX and CL-20; and (5) CL-20, HMX, and RDX are less and less sensitive to shock, suggesting chemical components are also a determining factor.

  15. 41 CFR 101-39.105 - Discontinuance or curtailment of service.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION, TRANSPORTATION, AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and Discontinuance of Interagency Fleet Management Systems § 101-39.105 Discontinuance or curtailment of service....

  16. Environmental and Pharmacological Modulation of Amphetamine-Induced 50-kHz Ultrasonic Vocalizations in Rats

    PubMed Central

    Rippberger, Henrike; van Gaalen, Marcel M.; Schwarting, Rainer K.W.; WÖhr, Markus

    2015-01-01

    Rats emit high-frequency 50-kHz ultrasonic vocalizations (USV) in appetitive situations like social interactions. Drugs of abuse are probably the most potent non-social elicitors of 50-kHz USV, possibly reflecting their euphorigenic properties. Psychostimulants induce the strongest elevation in 50-kHz USV emission, particularly amphetamine (AMPH), either when applied systemically or locally into the nucleus accumbens (Nacc). Emission of AMPH-induced 50-kHz USV depends on test context, such as the presence of conspecifics, and can be manipulated pharmacologically by targeting major neurotransmitter systems, including dopamine (DA), noradrenaline (NA), and serotonin (5-HT), but also protein kinase C (PKC) signaling. Several D1 and D2 receptor antagonists, as well as typical and atypical antipsychotics block the AMPH-induced elevation in 50-kHz USV. Inhibiting D1 and D2 receptors in the Nacc abolishes AMPH-induced 50-kHz USV, indicating a key role for this brain area. NA neurotransmission also regulates AMPH-induced 50-kHz USV emission given that α1 receptor antagonists and α2 receptor agonists exert attenuating effects. Supporting the involvement of the 5-HT system, AMPH-induced 50-kHz USV are attenuated by 5-HT2C receptor activation, whereas 5-HT2C receptor antagonism leads to the opposite effect. Finally, treatment with lithium, tamoxifen, and myricitrin was all found to result in a complete abolishment of the AMPH-induced increase in 50-kHz USV, suggesting the involvement of PKC signaling. Neurotransmitter systems involved in AMPH-induced 50-kHz USV emission only partially overlap with other AMPH-induced behaviors like hyperlocomotion. The validity of AMPH-induced 50-kHz USV as a preclinical model for neuropsychiatric disorders is discussed, particularly with relevance to altered drive and mood seen in bipolar disorder. PMID:26411764

  17. Thermally stable compositions including 2,4,8,10-tetranitro-5H-pyrido[3',2':4,5][1,2,3]triazolo[1,2-a]benzotriazo- l-6-ium, inner salt

    DOEpatents

    Hiskey, Michael A.; Huynh, My Hang

    2010-01-26

    An explosive formulation including 2,4,8,10-tetranitro-5H-pyrido[3',2':4,5][1,2,3]triazolo[1,2-a]benzotriazo- l-6-ium, inner salt and a high temperature binder is disclosed together with a process of preparing 2,4,8,10-tetranitro-5H-pyrido[3',2':4,5][1,2,3]triazolo[1,2-a]benzotriazo- l-6-ium, inner salt.

  18. Reactive oxygen species production and discontinuous gas exchange in insects

    PubMed Central

    Boardman, Leigh; Terblanche, John S.; Hetz, Stefan K.; Marais, Elrike; Chown, Steven L.

    2012-01-01

    While biochemical mechanisms are typically used by animals to reduce oxidative damage, insects are suspected to employ a higher organizational level, discontinuous gas exchange mechanism to do so. Using a combination of real-time, flow-through respirometry and live-cell fluorescence microscopy, we show that spiracular control associated with the discontinuous gas exchange cycle (DGC) in Samia cynthia pupae is related to reactive oxygen species (ROS). Hyperoxia fails to increase mean ROS production, although minima are elevated above normoxic levels. Furthermore, a negative relationship between mean and mean ROS production indicates that higher ROS production is generally associated with lower . Our results, therefore, suggest a possible signalling role for ROS in DGC, rather than supporting the idea that DGC acts to reduce oxidative damage by regulating ROS production. PMID:21865257

  19. Sharp monotonic resolution of discontinuities without clipping of narrow extrema

    NASA Technical Reports Server (NTRS)

    Leonard, B. P.; Niknafs, H. S.

    1991-01-01

    A strategy is presented for accurately simulating highly convective flows containing discontinuities such as density fronts or shock waves, without distorting smooth profiles or clipping narrow local extrema. The convection algorithm is based on non-artificially-diffusive third-order upwinding in smooth regions, with automatic adaptive stencil expansion to (in principle, arbitrarily) higher order upwinding locally, in regions of rapidly changing gradients. This is highly cost-effective because the wider stencil is used only where needed - in isolated narrow regions. A recently developed universal limiter assures sharp monotonic resolution of discontinuities without introducing artificial diffusion or numerical compression. An adaptive discriminator is constructed to distinguish between spurious overshoots and physical peaks; this automatically relaxes the limiter near local turning points, thereby avoiding loss of resolution in narrow extrema. Examples are given for one-dimensional pure convection of scalar profiles at constant velocity.

  20. Examining the spring discontinuity in daily temperature ranges

    SciTech Connect

    Schwartz, M.D.

    1996-04-01

    The atmosphere and biosphere both change rapidly throughout midlatitude spring. Many weather variables are modified during this season, including the diurnal temperature range (DTR). The mean DTR trend displays a discontinuity at the onset of spring characterized by a rapid increase for several weeks, followed by an abrupt leveling off. The trend then remains essentially flat throughout the remainder of the warm season. These DTR changes reflect the interactive role many weather variables play with surface-layer processes. Thus, diagnosing the causes of these variations may provide background information for numerous global change analyses, as daily temperature data become increasingly available worldwide. The results of this study suggest that several factors (snow cover loss, more frequent southerly winds, and increased ceiling heights) are responsible for the initial rapid increase in the DTR. The second half of the discontinuity (subsequent leveling off) is connected with increased atmospheric moisture and coincides with the onset of plant transpiration. 14 refs., 5 figs, 2 tabs.

  1. Discontinuous behavior of liquids between parallel and tilted plates

    SciTech Connect

    Concus, P.; Finn, R.

    1998-01-01

    Discontinuous behavior of liquids between parallel and tilted plates in the absence of gravity is discussed. A principal finding, derived mathematically from the classical Young{endash}Laplace{endash}Gauss formulation for capillary free surfaces, is that in a large range of configurations liquid bridges between parallel plates are unstable with respect to small, even infinitesimal, tilting of one of the plates. Under a computationally based hypothesis of uniqueness of spherical bridges in a wedge, it is shown that the same discontinuous behavior prevails for all but very particular circumstances. The various liquid configurations, which form the basis for an experiment on board the Space Station {ital Mir}, are characterized and illustrated. {copyright} {ital 1998 American Institute of Physics.}

  2. Numerically Tracking Contact Discontinuities with an Introduction for GPU Programming

    SciTech Connect

    Davis, Sean L

    2012-08-17

    We review some of the classic numerical techniques used to analyze contact discontinuities and compare their effectiveness. Several finite difference methods (the Lax-Wendroff method, a Multidimensional Positive Definite Advection Transport Algorithm (MPDATA) method and a Monotone Upstream Scheme for Conservation Laws (MUSCL) scheme with an Artificial Compression Method (ACM)) as well as the finite element Streamlined Upwind Petrov-Galerkin (SUPG) method were considered. These methods were applied to solve the 2D advection equation. Based on our results we concluded that the MUSCL scheme produces the sharpest interfaces but can inappropriately steepen the solution. The SUPG method seems to represent a good balance between stability and interface sharpness without any inappropriate steepening. However, for solutions with discontinuities, the MUSCL scheme is superior. In addition, a preliminary implementation in a GPU program is discussed.

  3. The Gutenberg discontinuity: melt at the lithosphere-asthenosphere boundary.

    PubMed

    Schmerr, Nicholas

    2012-03-23

    The lithosphere-asthenosphere boundary (LAB) beneath ocean basins separates the upper thermal boundary layer of rigid, conductively cooling plates from the underlying ductile, convecting mantle. The origin of a seismic discontinuity associated with this interface, known as the Gutenberg discontinuity (G), remains enigmatic. High-frequency SS precursors sampling below the Pacific plate intermittently detect the G as a sharp, negative velocity contrast at 40- to 75-kilometer depth. These observations lie near the depth of the LAB in regions associated with recent surface volcanism and mantle melt production and are consistent with an intermittent layer of asthenospheric partial melt residing at the lithospheric base. I propose that the G reflectivity is regionally enhanced by dynamical processes that produce melt, including hot mantle upwellings, small-scale convection, and fluid release during subduction.

  4. Kinetics of low-temperature discontinuous deformation of metals

    NASA Astrophysics Data System (ADS)

    Vorob'ev, E. V.; Anpilogova, T. V.

    2015-06-01

    Kinetic characteristics of discontinuous yielding at a temperature of 4 K as functions of a number of factors are obtained using numerical simulation and experimental data for austenitic steel and aluminum alloy. During the development of a strain jump, the deformation rate and acceleration are 19 s-1 and 5000 s-2, respectively, for steel specimens and are much lower for aluminum alloy. The jump duration is mainly determined by the characteristics of the loading system. An equation relating the strain jump and the critical stress for low-temperature ductile materials is derived. The energy balance and the mechanism of low-temperature discontinuous yielding of metals are discussed. Its dynamic and thermally activated components are estimated taking into account the strain hardening of the material.

  5. Reconciling Himalayan midcrustal discontinuities: The Main Central thrust system

    NASA Astrophysics Data System (ADS)

    Larson, Kyle P.; Ambrose, Tyler K.; Webb, A. Alexander G.; Cottle, John M.; Shrestha, Sudip

    2015-11-01

    The occurrence of thrust-sense tectonometamorphic discontinuities within the exhumed Himalayan metamorphic core can be explained as part of the Main Central thrust system. This imbricate thrust structure, which significantly thickened the orogenic midcrustal core, comprises a series of thrust-sense faults that all merge into a single detachment. The existence of these various structures, and their potential for complex overprinting along the main detachment, may help explain the contention surrounding the definition, mapping, and interpretation of the Main Central thrust. The unique evolution of specific segments of the Main Central thrust system along the orogen is interpreted to be a reflection of the inherent basement structure and ramp position, and structural level of exposure of the mid-crust. This helps explain the variation in the timing and structural position of tectonometamorphic discontinuities along the length of the mountain belt.

  6. The impact of discontinuing methylphenidate on weight and eating behavior.

    PubMed

    Benard, Victoire; Cottencin, Olivier; Guardia, Dewi; Vaiva, Guillaume; Rolland, Benjamin

    2015-04-01

    Chronic administration of the amphetamine-derivative methylphenidate (MPH) may induce appetite reduction and weight loss. By contrast, the effects that stopping chronic MPH may exert on eating behavior and body weight are poorly known. We report the case of a male patient with childhood attention deficit/hyperactivity disorder (ADHD), who discontinued MPH treatment at the age of 11 years and was lost to follow-up until the age of 16. The patient's body mass index increased by five points within 1 year of MPH cessation while the symptoms of ADHD were re-emerging. The patient secondarily developed DSM-5 criteria for eating disorders. Discontinuing chronic MPH can significantly affect weight and eating behavior. Such risks should warrant further studies, as they could be particularly increased in patients with ADHD, who share common vulnerability factors with both obesity and eating disorders.

  7. Discontinuous transition in a boundary driven contact process

    NASA Astrophysics Data System (ADS)

    Costa, A.; Blythe, R. A.; Evans, M. R.

    2010-09-01

    The contact process is a stochastic process which exhibits a continuous, absorbing state phase transition in the directed percolation (DP) universality class. In this work, we consider a contact process with a bias in conjunction with an active wall. This model exhibits waves of activity emanating from the active wall and, when the system is supercritical, propagating indefinitely as travelling (Fisher) waves. In the subcritical phase the activity is localized near the wall. We study the phase transition numerically and show that certain properties of the system, notably the wave velocity, are discontinuous across the transition. Using a modified Fisher equation to model the system we elucidate the mechanism by which the discontinuity arises. Furthermore we establish relations between properties of the travelling wave and DP critical exponents.

  8. Improving audible discontinuities in TTS over wireless networks system

    NASA Astrophysics Data System (ADS)

    Wang, Lijuan; Cao, Zhigang

    2004-04-01

    Mobile communication is now shaping our daily lives. However, as the end-user devices become increasingly smaller, the limited screen size and keyboard space start to bring about lots of inconvenience. Therefore, these conventional input/output methods are challenged by more natural interfaces, such as voice interface. Speech synthesis, which is one important aspect of voice interface, has so far been successfully applied to mobile phones to read email, instant messages for us. Nevertheless, these text-to-speech (TTS) systems, which are primarily based on concatenation of acoustic units, usually suffer from audible discontinuities between two successive acoustic units. This paper presents a novel method that can effectively remove the audible discontinuities in the Chinese speech synthesis and highly maintain the speech naturalness.

  9. Discontinuous solutions to hyperbolic systems under operator splitting

    NASA Technical Reports Server (NTRS)

    Roe, P. L.

    1987-01-01

    Two-dimensional systems of linear hyperbolic equations are studied with regard to their behavior under a solution strategy that in alternate time-steps solves exactly the component one-dimensional operators. The initial data is a step function across an oblique discontinuity. The manner in which this discontinuity breaks up under repeated applications of the split operator is analyzed, and it is shown that the split solution will fail to match the true solution in any case where the two operators do not share all their eigenvectors. The special case of the fluid flow equations is analyzed in more detail, and it is shown that arbitrary initial data gives rise to pseudo acoustic waves and a non-physical stationary wave. The implications of these findings for the design of high-resolution computing schemes are discussed.

  10. Discontinuously reinforced intermetallic matrix composites via XD synthesis. [exothermal dispersion

    NASA Technical Reports Server (NTRS)

    Kumar, K. S.; Whittenberger, J. D.

    1992-01-01

    A review is given of recent results obtained for discontinuously reinforced intermetallic matrix composites produced using the XD process. Intermetallic matrices investigated include NiAl, multiphase NiAl + Ni2AlTi, CoAl, near-gamma titanium aluminides, and Ll2 trialuminides containing minor amounts of second phase. Such mechanical properties as low and high temperature strength, compressive and tensile creep, elastic modulus, ambient ductility, and fracture toughness are discussed as functions of reinforcement size, shape, and volume fraction. Microstructures before and after deformation are examined and correlated with measured properties. An observation of interest in many of the systems examined is 'dispersion weakening' at high temperatures and high strain rates. This behavior is not specific to the XD process; rather similar observations have been reported in other discontinuous composites. Proposed mechanisms for this behavior are presented.

  11. Recovering pointwise values of discontinuous data within spectral accuracy

    NASA Technical Reports Server (NTRS)

    Gottlieb, D.; Tadmor, E.

    1985-01-01

    The pointwise values of a function, f(x), can be accurately recovered either from its spectral or pseudospectral approximations, so that the accuracy solely depends on the local smoothness of f in the neighborhood of the point x. Most notably, given the equidistant function grid values, its intermediate point values are recovered within spectral accuracy, despite the possible presence of discontinuities scattered in the domain. (Recall that the usual spectral convergence rate decelerates otherwise to first order, throughout). To this end, a highly oscillatory smoothing kernel is employed in contrast to the more standard positive unit-mass mollifiers. In particular, post-processing of a stable Fourier method applied to hyperbolic equations with discontinuous data, recovers the exact solution modulo a spectrally small error. Numerical examples are presented.

  12. A Streaming Language Implementation of the Discontinuous Galerkin Method

    NASA Technical Reports Server (NTRS)

    Barth, Timothy; Knight, Timothy

    2005-01-01

    We present a Brook streaming language implementation of the 3-D discontinuous Galerkin method for compressible fluid flow on tetrahedral meshes. Efficient implementation of the discontinuous Galerkin method using the streaming model of computation introduces several algorithmic design challenges. Using a cycle-accurate simulator, performance characteristics have been obtained for the Stanford Merrimac stream processor. The current Merrimac design achieves 128 Gflops per chip and the desktop board is populated with 16 chips yielding a peak performance of 2 Teraflops. Total parts cost for the desktop board is less than $20K. Current cycle-accurate simulations for discretizations of the 3-D compressible flow equations yield approximately 40-50% of the peak performance of the Merrimac streaming processor chip. Ongoing work includes the assessment of the performance of the same algorithm on the 2 Teraflop desktop board with a target goal of achieving 1 Teraflop performance.

  13. D″ discontinuity structure beneath the North Atlantic from Scd observations

    NASA Astrophysics Data System (ADS)

    Yao, Yao; Whittaker, Stefanie; Thorne, Michael S.

    2015-05-01

    We analyzed transverse and radial component recordings from the 2010 M6.3 southern Spain earthquake (depth = 620 km) recorded on 370 broadband stations in North America. We grouped these seismograms into subarrays and applied fourth root vespa processing (vespagram analysis) in order to enhance low-amplitude arrivals. These vespagrams show clear Scd arrivals which indicate the existence of the D″ discontinuity beneath the North Atlantic Ocean (45-60°N, 45-55°W). These observations are best fit with a +2-4% velocity increase at the top of the D″ discontinuity at a height above the core-mantle boundary of 304 ± 14 km. We do not observe Scd arrivals at the eastern end of our study region which is consistent with the presence of the easternmost edge of the ancient Farallon plate.

  14. Mapping Upper Mantle Seismic Discontinuities Using Singular Spectrum Analysis

    NASA Astrophysics Data System (ADS)

    Gu, Y. J.; Dokht, R.; Sacchi, M. D.

    2015-12-01

    Seismic discontinuities are fundamental to the understanding of mantle composition and dynamics. Their depth and impedance are generally determined using secondary seismic phases, most commonly SS precursors and P-to-S converted waves. However, the analysis and interpretation using these approaches often suffer from incomplete data coverage, high noise levels and interfering seismic phases, especially near tectonically complex regions such as subduction zones and continental margins. To overcome these pitfalls, we apply Singular Spectrum Analysis (SSA) to remove random noise, reconstruct missing traces and enhance the robustness of SS precursors and P-to-S conversions from seismic discontinuities. Our method takes advantage of the predictability of time series in frequency-space domain and performs a rank reduction using a singular value decomposition of the trajectory matrix. We apply SSA to synthetic record sections as well as observations of 1) SS precursors beneath the northwestern Pacific subduction zones, and 2) P-to-S converted waves from the Western Canada Sedimentary Basin (WCSB). In comparison with raw or interpolated data, the SSA enhanced reflectivity maps show a greater resolution and a stronger negative correlation between the depths of the 410 and 660 km discontinuities. These effects can be attributed to the suppression of incoherent noise, which tends to reduce the signal amplitude during normal averaging procedures, through rank reduction and the emphasis of principle singular values. Our new results suggest a more laterally coherent 520 km reflection in the western Pacific regions. Similar improvements in data imaging are achieved in western Canada, where strong lateral variations in discontinuity topography are observed in the craton-Cordillera boundary zone. Improvements from SSA relative to conventional approaches are most notable in under-sampled regions.

  15. Unfolding a codimension-two, discontinuous, Andronov-Hopf bifurcation.

    PubMed

    Simpson, D J W; Meiss, J D

    2008-09-01

    We present an unfolding of the codimension-two scenario of the simultaneous occurrence of a discontinuous bifurcation and an Andronov-Hopf bifurcation in a piecewise-smooth, continuous system of autonomous ordinary differential equations in the plane. We find that the Hopf cycle undergoes a grazing bifurcation that may be very shortly followed by a saddle-node bifurcation of the orbit. We derive scaling laws for the bifurcation curves that emanate from the codimension-two bifurcation.

  16. Fluorescence lifetime optical tomography with Discontinuous Galerkin discretisation scheme

    PubMed Central

    Soloviev, Vadim Y.; D'Andrea, Cosimo; Mohan, P. Surya; Valentini, Gianluca; Cubeddu, Rinaldo; Arridge, Simon R.

    2010-01-01

    We develop discontinuous Galerkin framework for solving direct and inverse problems in fluorescence diffusion optical tomography in turbid media. We show the advantages and the disadvantages of this method by comparing it with previously developed framework based on the finite volume discretization. The reconstruction algorithm was used with time-gated experimental dataset acquired by imaging a highly scattering cylindrical phantom concealing small fluorescent tubes. Optical parameters, quantum yield and lifetime were simultaneously reconstructed. Reconstruction results are presented and discussed. PMID:21258525

  17. Discontinuous Galerkin Finite Element Method for Parabolic Problems

    NASA Technical Reports Server (NTRS)

    Kaneko, Hideaki; Bey, Kim S.; Hou, Gene J. W.

    2004-01-01

    In this paper, we develop a time and its corresponding spatial discretization scheme, based upon the assumption of a certain weak singularity of parallel ut(t) parallel Lz(omega) = parallel ut parallel2, for the discontinuous Galerkin finite element method for one-dimensional parabolic problems. Optimal convergence rates in both time and spatial variables are obtained. A discussion of automatic time-step control method is also included.

  18. Computing Binary Black Hole Initial Data with Discontinuous Galerkin Methods

    NASA Astrophysics Data System (ADS)

    Vincent, Trevor; Pfeiffer, Harald

    2016-03-01

    Discontinuous Galerkin (DG) finite element methods have been used to solve hyperbolic PDEs in relativistic simulations and offer advantages over traditional discretization methods. Comparatively little attention has been given towards using the DG method to solve the elliptic PDEs arising from the Einstein initial data equations. We describe how the DG method can be used to create a parallel, adaptive solver for initial data. We discuss the use of our dG code to compute puncture initial data for binary black holes.

  19. Barkhausen discontinuities and hysteresis of ferromagnetics: New stochastic approach

    SciTech Connect

    Vengrinovich, Valeriy

    2014-02-18

    The magnetization of ferromagnetic material is considered as periodically inhomogeneous Markov process. The theory assumes both statistically independent and correlated Barkhausen discontinuities. The model, based on the chain evolution-type process theory, assumes that the domain structure of a ferromagnet passes successively the steps of: linear growing, exponential acceleration and domains annihilation to zero density at magnetic saturation. The solution of stochastic differential Kolmogorov equation enables the hysteresis loop calculus.

  20. Seismological detection of "730-km" discontinuity beneath Japan subduction zone

    NASA Astrophysics Data System (ADS)

    Liu, Z.; Park, J. J.; Karato, S. I.

    2015-12-01

    Because the mantle transition zone likely contains a large amount of water (Karato, 2011; Pearson et al., 2014), vertical material transport across the transition would cause partial melting that may produce seismic signals above and/or below the transition zone. Schmandt et al. (2014) observed a seismic low-velocity zone (LVZ) at the top of the lower mantle (~730 km) beneath the southwestern US, arguing for dehydration melting due to downward flow across the 670-km discontinuity (670) from the transition zone. These authors further proposed a correlation between seismic velocity reductions and the direction of water transport, in which LVZ at ~730 km indicates materials moving downward from the transition zone, while the lack of LVZ at this depth would suggest an upward flow of mantle materials. Other regions also need to be investigated to confirm the correlation between this seismic feature and mantle water transport. We test their model by detecting "730-km" discontinuity beneath the Japan subduction zone using frequency-dependent receiver functions. In addition, water transport above the 410-km discontinuity (410) also plays an important role in global water circulation (Bercovici and Karato, 2003). Seismological studies (e.g. Courtier and Revenaugh, 2007; Schaeffer and Bostock, 2010) have observed LVZs above the 410, which might be caused by dehydration melting due to the upwelling of hydrated materials across the 410-km discontinuity from the transition zone. In this study, we also detect potential LVZs above 410 to establish a correlation between seismic velocity drop and flow direction. Around the Japan subduction zone, our preliminary results show evidence of low velocity zones below 670 in regions where stagnant slab is present for a substantial amount of time but not in other regions suggesting a variety of vertical mass transport in this region. Key words: transition zone, water transport, subduction zone, melting, receiver functions

  1. On various criticisms of the contact discontinuity model

    NASA Astrophysics Data System (ADS)

    Shu, F. H.; Lubow, S. H.; Anderson, L.

    1980-08-01

    We discuss various criticisms raised recently by Lucy and Wilson, by Papaloizou and Pringle, and by Smith, Robertson, and Smith against the contact discontinuity model for contact binaries. In the process we discover a promising means by which the filled fraction occupied by the common envelope could, in principle, be determined mechanistically for a contact binary of given total mass, angular momentum, initial chemical composition, and age.

  2. Discontinuous pressure effect upon enantiodifferentiating photosensitized isomerization of cyclooctene.

    PubMed

    Kaneda, Masayuki; Asaoka, Sadayuki; Ikeda, Haruhiko; Mori, Tadashi; Wada, Takehiko; Inoue, Yoshihisa

    2002-06-21

    A hydrostatic pressure of up to 750 MPa induced discontinuous changes in the enantiomeric excess of the (E)-isomer obtained in the enantio-differentiating photoisomerization of (Z)-cyclooctene and (Z,Z)-cycloocta-1,5-diene, sensitized by chiral benzene-1,2,4,5-tetracarboxylates; indicating a switching of the enantio-differentiation mechanism, which is attributable to dramatic conformational changes of chiral alkoxycarbonyl auxiliaries at a specific pressure.

  3. Why do couples discontinue unlimited free IVF treatments?

    PubMed

    Lande, Yechezkel; Seidman, Daniel S; Maman, Ettie; Baum, Micha; Hourvitz, Ariel

    2015-03-01

    Worldwide, IVF is often discontinued before a live birth is achieved due to high costs. Even when partial financial coverage is provided, often medical providers advise treatment discontinuation. In Israel, unlimited IVF is offered free of charge for a couples' first two children. Our objective was to assess the reasons couples discontinue IVF treatments before achieving two children in a completely unlimited cost-free environment. This cohort study included all primary infertile women, <35 years, referred for their first IVF cycle to Sheba IVF unit between 2001 and 2002. Patients were followed until February 2012. Those who ceased treatments for 12 months were interviewed to assess the main reason they ceased treatments. Of the 134 couples included, only 46 ceased IVF treatments without achieving two children, after performing an average of 6.2 IVF cycles to achieve their first birth. The reasons given were: lost hope of success (13), psychological burden (18), divorce (6), medical staff recommendation (5), bureaucratic difficulties (3) and general medical condition (1). The main reasons for "drop out" in our cost-free environment were as follows: psychological burden and lost hope of success. Due to high availability of treatments, medical staff recommendation was a less significant factor in our study.

  4. Discontinued students in nursing education - Who and why?

    PubMed

    Kukkonen, Pia; Suhonen, Riitta; Salminen, Leena

    2016-03-01

    There has been increasing interest in student nurse attrition due to the high level of attrition rates in many countries. Studies about nursing education and attrition have been conducted internationally, but only a few have explored attrition from the perspective of the students' own experiences. The purpose of this study was to describe who is a discontinued student in nursing education and the students' own experiences of reasons for leaving a nursing school. A descriptive design and qualitative approach was used. 25 nursing students were interviewed at two different universities of applied sciences in Finland. Four different types of discontinued nursing students were identified: those who moved to another school, those who faced a life crisis, those who made the wrong career choice and those who lived 'busy years'. The results show that the nursing student population is diverse, which has an effect on the students' career intentions, their learning and their ability to cope with studies. In nursing education, it is important to identify students who are at risk of discontinue their studies and develop individual support systems to help nursing students complete their studies and enter into the workforce.

  5. Local error estimates for discontinuous solutions of nonlinear hyperbolic equations

    NASA Technical Reports Server (NTRS)

    Tadmor, Eitan

    1989-01-01

    Let u(x,t) be the possibly discontinuous entropy solution of a nonlinear scalar conservation law with smooth initial data. Suppose u sub epsilon(x,t) is the solution of an approximate viscosity regularization, where epsilon greater than 0 is the small viscosity amplitude. It is shown that by post-processing the small viscosity approximation u sub epsilon, pointwise values of u and its derivatives can be recovered with an error as close to epsilon as desired. The analysis relies on the adjoint problem of the forward error equation, which in this case amounts to a backward linear transport with discontinuous coefficients. The novelty of this approach is to use a (generalized) E-condition of the forward problem in order to deduce a W(exp 1,infinity) energy estimate for the discontinuous backward transport equation; this, in turn, leads one to an epsilon-uniform estimate on moments of the error u(sub epsilon) - u. This approach does not follow the characteristics and, therefore, applies mutatis mutandis to other approximate solutions such as E-difference schemes.

  6. Mantle discontinuities and temperature under the North American continental keel

    NASA Astrophysics Data System (ADS)

    Li, Aibing; Fischer, Karen M.; Wysession, Michael E.; Clarke, Timothy J.

    1998-09-01

    A ubiquitous feature of upper-mantle seismic velocity models has been the presence of high-velocity `keels' beneath stable continental interiors. Uncertainty remains, however, regarding the maximum depth to which continental keels extend, the degree to which they have cooled the mantle that surrounds them and their role in mantle flow. Here we investigate thermal anomalies across the eastern margin of the North American continental keel by imaging the seismic discontinuities at depths of 410 and 660km with compressional-to-shear converted waves recorded by a 1,500-km-long seismometer deployment in the eastern United States. The thickness of the transition zone (the region nominally between depths of 410 and 660km) and the depth to the `410-km' discontinuity indicate that cold keel material and sub-keel downwellings must be largely confined to the upper mantle and may impinge on the transition zone only in localized regions and with thermal anomalies of less than ~150K. A 20-km depression of the `660-km' discontinuity to the south of the westernmost stations coincides with a region of fast velocity in the deep transition zone and may be associated with the remnants of the subducted Farallon plate,,.

  7. Sub-kHz Linewidth GaSb Semiconductor Diode Lasers Operating Near 2 Micrometers

    NASA Technical Reports Server (NTRS)

    Bagheri, Mahmood; Briggs, Ryan M.; Frez, Clifford; Ksendzov, Alexander; Forouhar, Siamak

    2012-01-01

    We report on the phase noise properties of DFB lasers operating near 2.0 microns. Measured noise spectra indicate intrinsic laser linewidths below 1 kHz. An effective linewidth of less than 200 kHz for 5 ms measurement times is estimated.

  8. The 1983-84 Connecticut 45-Hz-band field-strength measurements

    NASA Astrophysics Data System (ADS)

    Bannister, P. R.

    1986-03-01

    Extremely low frequency (ELF) measurements are made of the transverse horizontal magnetic field strength received in Connecticut. The AN/BSR-1 receiver consists of an AN/UYK-20 minicomputer, a signal timing and interface unit (STIU), a rubidium frequency time standard, two magnetic tape recorders, and a preamplifier. The transmission source of these farfield (1.6-Mm range) measurements is the U.S. Navy's ELF Wisconsin Test Facility (WTF), located in the Chequamegon National Forest in north central Wisconsin, about 8 km south of the village of Clam Lake. The WTF consists of two 22.5-km antennas; one of which is situated approximately in the north-south (NS) direction and the other approximately in the east-west (EW) direction. Each antenna is grounded at both ends. The electrical axis of the WTF EW antenna is 11 deg east of north at 45 Hz and 14 deg east of north at 75Hz. The electrical axis of the WTF NS antenna is 11 deg east of north at 45 Hz and 14 deg east of north at 75 Hz. The WTF array can be steered electrically. Its radiated power is approximately 0.5 W at 45 Hz and 1 W at 75 Hz. This report will compare results of 45 Hz band data taken during 1983 to 1984 with previous 45 Hz band measurements.

  9. Development and testing of a 20-kHz component test bed

    NASA Technical Reports Server (NTRS)

    Button, Robert M.; Brush, Andrew S.; Sundberg, Richard C.

    1989-01-01

    A history of the General Dynamics Space Systems Division 20 kHz Breadboard is presented including its current configuration and its role in the Space Station Freedom (SSF) program. Highlights and results are presented on a series of tests conducted on the 20 kHz Breadboard. The first test presented is the 20 kHz Breadboard Acceptance test. This test verified the operation of the delivered Breadboard and also characterized the main components of the system. Next, an indepth efficiency testing effort is presented. The tests attempted to apportion all the power losses in the 20 kHz Breadboard Main Invert Units. Distortion test data is presented showing the distortion characteristics of a Mapham inverter. Lastly, current work on the 20 kHz Breadboard is presented including Main Inverter Unit paralleling tests. Conclusions are summarized and references given.

  10. The Hales discontinuity and upper mantle anisotropy beneath cratons

    NASA Astrophysics Data System (ADS)

    Musacchio, G.; White, D. J.; Thomson, C. J.

    2003-04-01

    Seismic velocity discontinuities are commonly found within the upper 100 km of the mantle lithosphere, with great variability in their depth, lateral extent, and the polarity of velocity jump. Among the more commonly observed is the Hales discontinuity, identified in a variety of tectonic environments, and commonly associated with a high-velocity, highly reflective and sometimes anisotropic layer. In the Archean Western Superior Province of the Canadian Shield, long range R/WAR profiling gives a high-resolution estimate of the mantle V_P in the shallow upper mantle, providing a more certain determination of the nature of the Hales dicontinuity. Ray-based travel-time inversion of the data, have shown that Vp in the uppermost mantle is 8.0-8.3 km/s. A 15-20 km thick layer (layer-H) with >6% seismic anisotropy (N-S V_P of 8.3 km/s and E-W V_P of 8.8 km/s) dips northward at ˜10^o from a minimum depth of 48-50 km. The attitude of layer-H is consistent with the general tectonic strike; its depth range (50-75 km) falls within that of the Hales discontinuity. If a link between the Hales discontinuity and layer-H can be drawn, observations strengthen the objection that the estimated velocity contrast (0.2 to 0.4 km/s depending on the direction of wave propagation) is relatively high if layer-H represents a phase transition, and thus (re)opens the debate on the nature of shallow upper-mantle boundaries beneath continents. The high V_P and intermediate anisotropy of upper-mantle layer-H requires a harzburgite peridotitic composition with the a-axis of olivine aligned E-W. Layer-H might have emplaced during accretion (2.7 Ga Kenoran orogeny) of the North American proto-craton and be relic oceanic lithosphere. The Hales discontinuity might be an expression of continents accretion and map relic slabs in the shallow upper mantle.

  11. Human exposure standards in the frequency range 1 Hz To 100 kHz: the case for adoption of the IEEE standard.

    PubMed

    Patrick Reilly, J

    2014-10-01

    Differences between IEEE C95 Standards (C95.6-2002 and C95.1-2005) in the low-frequency (1 Hz-100 kHz) and the ICNIRP-2010 guidelines appear across the frequency spectrum. Factors accounting for lack of convergence include: differences between the IEEE standards and the ICNIRP guidelines with respect to biological induction models, stated objectives, data trail from experimentally derived thresholds through physical and biological principles, selection and justification of safety/reduction factors, use of probability models, compliance standards for the limbs as distinct from the whole body, defined population categories, strategies for central nervous system protection below 20 Hz, and correspondence of environmental electric field limits with contact currents. This paper discusses these factors and makes the case for adoption of the limits in the IEEE standards.

  12. A reference-beam autocollimator with nanoradian sensitivity from mHz to kHz and dynamic range of 107

    NASA Astrophysics Data System (ADS)

    Arp, T. B.; Hagedorn, C. A.; Schlamminger, S.; Gundlach, J. H.

    2013-09-01

    We describe an autocollimating optical angle sensor with a dynamic range of 9 mrad and nrad/sqrt{textrm {Hz}} sensitivity at frequencies from 5 mHz to 3 kHz. This work improves the standard multi-slit autocollimator design by adding two optical components, a reference mirror and a condensing lens. This autocollimator makes a differential measurement between a reference mirror and a target mirror, suppressing common-mode noise sources. The condensing lens reduces optical aberrations, increases intensity, and improves image quality. To further improve the stability of the device at low frequencies the body of the autocollimator is designed to reduce temperature variations and their effects. A new data processing technique was developed in order to suppress the effects of imperfections in the CCD.

  13. A reference-beam autocollimator with nanoradian sensitivity from mHz to kHz and dynamic range of 10(7).

    PubMed

    Arp, T B; Hagedorn, C A; Schlamminger, S; Gundlach, J H

    2013-09-01

    We describe an autocollimating optical angle sensor with a dynamic range of 9 mrad and nrad/√Hz sensitivity at frequencies from 5 mHz to 3 kHz. This work improves the standard multi-slit autocollimator design by adding two optical components, a reference mirror and a condensing lens. This autocollimator makes a differential measurement between a reference mirror and a target mirror, suppressing common-mode noise sources. The condensing lens reduces optical aberrations, increases intensity, and improves image quality. To further improve the stability of the device at low frequencies the body of the autocollimator is designed to reduce temperature variations and their effects. A new data processing technique was developed in order to suppress the effects of imperfections in the CCD.

  14. Physico-chemical constraints on cratonic lithosphere discontinuities

    NASA Astrophysics Data System (ADS)

    Aulbach, Sonja; Rondenay, Stéphane; Huismans, Ritske

    2014-05-01

    The origins of the mid-lithospheric discontinuity (MLD) and lithosphere-asthenosphere boundary (LAB) have received much attention over the recent years. Peculiarities of cratonic lithosphere construction - compositional and rheological stratification due to thickening in collisional settings or by plume subcretion, multiple metasomatic overprints due to longevity - offer a variety of possibilities for the generation of discontinuities. Interconnected small degrees of conductive partial melt (carbonate-rich melts, such as carbonatites and kimberlites, or highly alkaline melts) at the cratonic LAB, which produce seismic discontinuities, may be generated in the presence of volatiles. These depress the peridotite solidus sufficiently to intersect the mantle adiabat at depths near the cratonic LAB at ~160-220 km, i.e. above the depth of metal saturation where carbonatite becomes unstable. The absence of agreement between the different seismic and magnetotelluric estimates for the depth of the LAB beneath Kaapvaal may be due to impingement of a plume, leading to a pervasively, but heterogeneously metasomatised ('asthenospherised') hot and deep root. Such a root and hot sublithosphere may yield conflicting seismic-thermal-geochemical depths for the LAB. The question arises whether the chemical boundary layer should be defined as above or below the asthenospherised part of the SCLM, which has preserved isotopic, compositional (non-primitive olivine forsterite content) and physical evidence (e.g. from teleseismic tomography and receiver functions) for a cratonic heritage and which therefore is still distinguishable from the asthenospheric mantle. If cratonic lithosphere overlies anomalously hot mantle for extended periods of time, the LAB may be significantly thinned, aided by penetration of relatively high-degree Fe-rich partial melts, as has occurred beneath the Tanzanian craton. Xenoliths from the deep Slave craton show little evidence for 'asthenospherisation'. Its root

  15. Observations in variations in the amplitude and depths of the 410 and 520 km discontinuities from PdP and SdS bounce point studies.

    NASA Astrophysics Data System (ADS)

    Darensburg, A.; Ainiwaer, A.; Gurrola, H.

    2015-12-01

    To gain a better understanding of the upper mantle transition zone, we beamform EarthScope Transportable array data of events from the western Pacific ring of fire to produce relatively high frequency (0.75 Hz) PdP functions (underside P reflections from a depth d) of the mantle beneath the central Pacific from the society Islands across the Aleutian trench. Like most PdP studies, we fail to image the 660 km discontinuity so we focus on the 410, and 520. It is believed that the 410 and 520 km discontinuities are the result of exothermic phase changes in the Olivine mineral system at pressure and temperatures consistent with the indicated depths. Because these boundaries are hypothesized to be exothermic, we expect them to be deeper in hot regions and shallow in cool. Modeling of these boundaries by mineral physicists suggest the 410 occurs over a 10 km interval and the 520 over about 30 km. Our observed amplitudes of P410P as a function of frequency compared to waveform modeling indicate that the 410 phase change must occur over less 6 km. Our observations of a strong 520 km discontinuity at 0.75 Hz also suggests that this velocity contrast occurs over less than 10 km rather than the hypothesized 30 km. We found that the average depth to the 410 km discontinuity across our study area to be 420 km to 425km. The 520 km discontinuity appears to be strongest around Hawaii and north of the Aleutian trench. The depths of the P410P and P520P phases appear to be correlated in most areas where they occur together; deepest the north of the Aleutian trench and southwestern Alaska; and shallowest south of the westernmost Aleutian trench. One of the more surprising observations was that the P520P phase appears to be the smallest or not observable in regions with the strongest P410P phase. SdS observations will be added to this study for the AGU meeting.

  16. Discontinuity interaction and anomalous source models in through transmission eddy current testing

    SciTech Connect

    Mergelas, B.J.; Atherton, D.L.

    1996-01-01

    Growing interest in the detection of external, axially aligned stress corrosion cracks in ferromagnetic oil and gas transmission pipelines, has prompted a detailed investigation of discontinuity interactions in remote field eddy current (RFEC) testing. Experimental measurements and numerical modeling were undertaken to study discontinuity interactions in a single through-wall transmission geometry for ferromagnetic and nonferromagnetic pipes. Anomalous source models have been introduced in order to explain the responses of axial discontinuities to circumferential eddy currents or circumferential AC magnetic fields. In nonferromagnetic material, discontinuity responses may be modeled by two types of anomalous eddy current sources. In ferromagnetic materials, an anomalous magnetization source is useful for explaining discontinuity response.

  17. The effect of 10 Hz transcranial alternating current stimulation (tACS) on corticomuscular coherence

    PubMed Central

    Wach, Claudia; Krause, Vanessa; Moliadze, Vera; Paulus, Walter; Schnitzler, Alfons; Pollok, Bettina

    2013-01-01

    Synchronous oscillatory activity at alpha (8–12 Hz), beta (13–30 Hz), and gamma (30–90 Hz) frequencies is assumed to play a key role for motor control. Corticomuscular coherence (CMC) represents an established measure of the pyramidal system's integrity. Transcranial alternating current stimulation (tACS) offers the possibility to modulate ongoing oscillatory activity. Behaviorally, 20 Hz tACS in healthy subjects has been shown to result in movement slowing. However, the neurophysiological changes underlying these effects are not entirely understood yet. The present study aimed at ascertaining the effects of tACS at 10 and 20 Hz in healthy subjects on CMC and local power of the primary sensorimotor cortex. Neuromagnetic activity was recorded during isometric contraction before and at two time points (2–10 min and 30–38 min) after tACS of the left primary motor cortex (M1), using a 306 channel whole head magnetoencephalography (MEG) system. Additionally, electromyography (EMG) of the right extensor digitorum communis (EDC) muscle was measured. TACS was applied at 10 and 20 Hz, respectively, for 10 min at 1 mA. Sham stimulation served as control condition. The data suggest that 10 Hz tACS significantly reduced low gamma band CMC during isometric contraction. This implies that tACS does not necessarily cause effects at stimulation frequency. Rather, the findings suggest cross-frequency interplay between alpha and low gamma band activity modulating functional interaction between motor cortex and muscle. PMID:24009573

  18. Interferometric readout of a monolithic accelerometer, towards the fm /√{ Hz } resolution

    NASA Astrophysics Data System (ADS)

    van Heijningen, J. V.; Bertolini, A.; van den Brand, J. F. J.

    2016-07-01

    The European Gravitational wave Observatory Virgo is undergoing an upgrade to increase its strain sensitivity to about 3 ×10-24 1 /√{ Hz } in the detection band of 10 Hz-10 kHz. The upgrade for this detector necessitates seismically isolating sensing optics in a vacuum environment that were on an optical bench outside vacuum in previous Virgo configurations. For this purpose, Nikhef has designed and built the five compact isolators, called MultiSAS. To measure the residual motion of the optical components and the transfer function of the isolator in full assembly, no (commercial) sensor is available that has sufficient sensitivity. A novel vibration sensor has been built at Nikhef that features an interferometric readout for a horizontal monolithic accelerometer. It will be able to measure in the vicinity of the fm/Hz regime from 10 Hz onwards. Current results show unprecedented (self) noise levels around 35 fm/Hz from 25 Hz onwards. In spite of these excellent results, it is still higher than the modeled noises. Several possible unmodeled noise sources and possible solutions have been identified.

  19. The Effect of Levothyroxine Discontinuation Timing on Postoperative Hypothyroidism after Hemithyroidectomy for Papillary Thyroid Microcarcinoma

    PubMed Central

    Ha, Tae Kwun; Kim, Dong Wook; Park, Ha Kyoung; Baek, Jin Wook; Lee, Yoo Jin; Park, Young Mi; Kim, Do Hun; Jung, Soo Jin; Ahn, Ki Jung

    2016-01-01

    Objective. No previous studies regarding the appropriate timing of thyroid hormone discontinuation after hemithyroidectomy have been published. This study aimed to identify the appropriate timing for levothyroxine discontinuation after hemithyroidectomy among patients with papillary thyroid microcarcinoma (PTMC). Methods. This study retrospectively evaluated 304 patients who underwent ≥1 attempt to discontinue levothyroxine after hemithyroidectomy for treating PTMC between January 2008 and December 2013. Fifty-three patients were excluded because of preoperative hypothyroidism or hyperthyroidism, a history of thyroid hormone or antithyroid therapy, no available serological data, or a postoperative follow-up of <24 months. We evaluated the associations of successful levothyroxine discontinuation with patient age, sex, preoperative serological data, underlying thyroid gland histopathology, anteroposterior diameter of the residual thyroid gland, number of discontinuation attempts, and initial discontinuation timing. Results. Among the 251 included patients, 125 patients (49.8%) achieved successful levothyroxine discontinuation during the follow-up period after hemithyroidectomy. There was a significant difference in the outcomes for patients who underwent an initial discontinuation attempt at ≤3 months and ≥4 months after hemithyroidectomy (p < 0.001). There were significant differences in the discontinuation outcomes according to underlying thyroid histopathology (p = 0.001), preoperative thyroid-stimulating hormone levels (p < 0.001), and number of discontinuation attempts (p < 0.001). Conclusions. Among patients with PTMC, the initial levothyroxine discontinuation attempt is recommended at ≥4 months after hemithyroidectomy. PMID:27293432

  20. The Effect of Levothyroxine Discontinuation Timing on Postoperative Hypothyroidism after Hemithyroidectomy for Papillary Thyroid Microcarcinoma.

    PubMed

    Ha, Tae Kwun; Kim, Dong Wook; Park, Ha Kyoung; Baek, Jin Wook; Lee, Yoo Jin; Park, Young Mi; Kim, Do Hun; Jung, Soo Jin; Ahn, Ki Jung

    2016-01-01

    Objective. No previous studies regarding the appropriate timing of thyroid hormone discontinuation after hemithyroidectomy have been published. This study aimed to identify the appropriate timing for levothyroxine discontinuation after hemithyroidectomy among patients with papillary thyroid microcarcinoma (PTMC). Methods. This study retrospectively evaluated 304 patients who underwent ≥1 attempt to discontinue levothyroxine after hemithyroidectomy for treating PTMC between January 2008 and December 2013. Fifty-three patients were excluded because of preoperative hypothyroidism or hyperthyroidism, a history of thyroid hormone or antithyroid therapy, no available serological data, or a postoperative follow-up of <24 months. We evaluated the associations of successful levothyroxine discontinuation with patient age, sex, preoperative serological data, underlying thyroid gland histopathology, anteroposterior diameter of the residual thyroid gland, number of discontinuation attempts, and initial discontinuation timing. Results. Among the 251 included patients, 125 patients (49.8%) achieved successful levothyroxine discontinuation during the follow-up period after hemithyroidectomy. There was a significant difference in the outcomes for patients who underwent an initial discontinuation attempt at ≤3 months and ≥4 months after hemithyroidectomy (p < 0.001). There were significant differences in the discontinuation outcomes according to underlying thyroid histopathology (p = 0.001), preoperative thyroid-stimulating hormone levels (p < 0.001), and number of discontinuation attempts (p < 0.001). Conclusions. Among patients with PTMC, the initial levothyroxine discontinuation attempt is recommended at ≥4 months after hemithyroidectomy. PMID:27293432

  1. Automatic extraction of discontinuity orientation from rock mass surface 3D point cloud

    NASA Astrophysics Data System (ADS)

    Chen, Jianqin; Zhu, Hehua; Li, Xiaojun

    2016-10-01

    This paper presents a new method for extracting discontinuity orientation automatically from rock mass surface 3D point cloud. The proposed method consists of four steps: (1) automatic grouping of discontinuity sets using an improved K-means clustering method, (2) discontinuity segmentation and optimization, (3) discontinuity plane fitting using Random Sample Consensus (RANSAC) method, and (4) coordinate transformation of discontinuity plane. The method is first validated by the point cloud of a small piece of a rock slope acquired by photogrammetry. The extracted discontinuity orientations are compared with measured ones in the field. Then it is applied to a publicly available LiDAR data of a road cut rock slope at Rockbench repository. The extracted discontinuity orientations are compared with the method proposed by Riquelme et al. (2014). The results show that the presented method is reliable and of high accuracy, and can meet the engineering needs.

  2. Low potency and limited efficacy of antiepileptic drugs in the mouse 6 Hz corneal kindling model.

    PubMed

    Leclercq, K; Matagne, A; Kaminski, R M

    2014-05-01

    Corneal kindling is a useful alternative to electrically induced amygdala or hippocampal kindling, which requires advanced surgical and EEG techniques that may not be easily available in many laboratories. Therefore the first aim of this study was to evaluate whether repeated 6 Hz corneal stimulation in mice would lead to an increased and persistent seizure response as described for higher frequency (50/60 Hz) corneal kindling. Male NMRI mice stimulated twice daily (except weekends) for 3 s with 6 Hz electrical current at 44 mA displayed robust kindling development, i.e., a progressive increase in seizure severity. The majority of the animals (about 90%) developed a fully kindled state, defined as at least 10 consecutive stage 3-5 seizures within 5 weeks of corneal stimulation. Afterwards, the fully kindled state was maintained for at least 8 weeks with only two days of stimulations per week. Next, the protective efficacy of four mechanistically different antiepileptic drugs (AEDs; clonazepam, valproate, carbamazepine and levetiracetam) was assessed and compared between 6 Hz and 50 Hz fully kindled mice. All tested AEDs showed a relatively lower potency in the 6 Hz kindling model and a limited efficacy against partial seizures was observed with carbamazepine and levetiracetam. We can conclude that 6 Hz kindling may be more advantageous than the previously described 50/60 Hz corneal kindling models due to its robustness and persistence of the fully kindled state. Furthermore, the observed low potency and limited efficacy of AEDs in 6 Hz fully kindled mice suggest that this model could be a useful tool in the discovery of novel AEDs targeting treatment resistant epilepsy.

  3. Air puff-induced 22-kHz calls in F344 rats.

    PubMed

    Inagaki, Hideaki; Sato, Jun

    2016-03-01

    Air puff-induced ultrasonic vocalizations in adult rats, termed "22-kHz calls," have been applied as a useful animal model to develop psychoneurological and psychopharmacological studies focusing on human aversive affective disorders. To date, all previous studies on air puff-induced 22-kHz calls have used outbred rats. Furthermore, newly developed gene targeting technologies, which are essential for further advancement of biomedical experiments using air puff-induced 22-kHz calls, have enabled the production of genetically modified rats using inbred rat strains. Therefore, we considered it necessary to assess air puff-induced 22-kHz calls in inbred rats. In this study, we assessed differences in air puff-induced 22-kHz calls between inbred F344 rats and outbred Wistar rats. Male F344 rats displayed similar total (summed) duration of air puff-induced 22 kHz vocalizations to that of male Wistar rats, however, Wistar rats emitted fewer calls of longer duration, while F344 rats emitted higher number of vocalizations of shorter duration. Additionally, female F344 rats emitted fewer air puff-induced 22-kHz calls than did males, thus confirming the existence of a sex difference that was previously reported for outbred Wistar rats. The results of this study could confirm the reliability of air puff stimulus for induction of a similar amount of emissions of 22-kHz calls in different rat strains, enabling the use of air puff-induced 22-kHz calls in inbred F344 rats and derived genetically modified animals in future studies concerning human aversive affective disorders.

  4. 4 Hz oscillations synchronize prefrontal-amygdala circuits during fear behaviour

    PubMed Central

    Karalis, Nikolaos; Dejean, Cyril; Chaudun, Fabrice; Khoder, Suzana; Rozeske, Robert R.; Wurtz, Hélène; Bagur, Sophie; Benchenane, Karim; Sirota, Anton; Courtin, Julien; Herry, Cyril

    2016-01-01

    Fear expression relies on the coordinated activity of prefrontal and amygdala circuits, yet the mechanisms allowing long-range network synchronization during fear remain unknown. Using a combination of extracellular recordings, pharmacological, and optogenetic manipulations we report that freezing, a behavioural expression of fear, temporally coincides with the development of sustained, internally generated 4 Hz oscillations within prefrontal-amygdala circuits. 4 Hz oscillations predict freezing onset and offset and synchronize prefrontal-amygdala circuits. Optogenetic induction of prefrontal 4 Hz oscillations coordinates prefrontal-amygdala activity and elicits fear behaviour. These results unravel a novel sustained oscillatory mechanism mediating prefrontal-amygdala coupling during fear behaviour. PMID:26878674

  5. 4-Hz oscillations synchronize prefrontal-amygdala circuits during fear behavior.

    PubMed

    Karalis, Nikolaos; Dejean, Cyril; Chaudun, Fabrice; Khoder, Suzana; Rozeske, Robert R; Wurtz, Hélène; Bagur, Sophie; Benchenane, Karim; Sirota, Anton; Courtin, Julien; Herry, Cyril

    2016-04-01

    Fear expression relies on the coordinated activity of prefrontal and amygdala circuits, yet the mechanisms allowing long-range network synchronization during fear remain unknown. Using a combination of extracellular recordings, pharmacological and optogenetic manipulations, we found that freezing, a behavioral expression of fear, temporally coincided with the development of sustained, internally generated 4-Hz oscillations in prefrontal-amygdala circuits. 4-Hz oscillations predict freezing onset and offset and synchronize prefrontal-amygdala circuits. Optogenetic induction of prefrontal 4-Hz oscillations coordinates prefrontal-amygdala activity and elicits fear behavior. These results unravel a sustained oscillatory mechanism mediating prefrontal-amygdala coupling during fear behavior. PMID:26878674

  6. Benefits of 20 kHz PMAD in a nuclear space station

    NASA Astrophysics Data System (ADS)

    Sundberg, Gale R.

    Compared to existing systems, high frequency ac power provides higher efficiency, lower cost, and improved safety benefits. The 20 kHz power system has exceptional flexibility, is inherently user friendly, and is compatible with all types of energy sources; photovoltaic, solar dynamic, rotating machines and nuclear. A 25 kW, 20 kHz ac power distribution system testbed was recently (1986) developed. The testbed possesses maximum flexibility, versatility, and transparency to user technology while maintaining high efficiency, low mass, and reduced volume. Several aspects of the 20 kHz power management and distribution (PMAD) system that have particular benefits for a nuclear power Space Station are discussed.

  7. Benefits of 20 kHz PMAD in a nuclear space station

    NASA Technical Reports Server (NTRS)

    Sundberg, Gale R.

    1987-01-01

    Compared to existing systems, high frequency ac power provides higher efficiency, lower cost, and improved safety benefits. The 20 kHz power system has exceptional flexibility, is inherently user friendly, and is compatible with all types of energy sources; photovoltaic, solar dynamic, rotating machines and nuclear. A 25 kW, 20 kHz ac power distribution system testbed was recently (1986) developed. The testbed possesses maximum flexibility, versatility, and transparency to user technology while maintaining high efficiency, low mass, and reduced volume. Several aspects of the 20 kHz power management and distribution (PMAD) system that have particular benefits for a nuclear power Space Station are discussed.

  8. 4-Hz oscillations synchronize prefrontal-amygdala circuits during fear behavior.

    PubMed

    Karalis, Nikolaos; Dejean, Cyril; Chaudun, Fabrice; Khoder, Suzana; Rozeske, Robert R; Wurtz, Hélène; Bagur, Sophie; Benchenane, Karim; Sirota, Anton; Courtin, Julien; Herry, Cyril

    2016-04-01

    Fear expression relies on the coordinated activity of prefrontal and amygdala circuits, yet the mechanisms allowing long-range network synchronization during fear remain unknown. Using a combination of extracellular recordings, pharmacological and optogenetic manipulations, we found that freezing, a behavioral expression of fear, temporally coincided with the development of sustained, internally generated 4-Hz oscillations in prefrontal-amygdala circuits. 4-Hz oscillations predict freezing onset and offset and synchronize prefrontal-amygdala circuits. Optogenetic induction of prefrontal 4-Hz oscillations coordinates prefrontal-amygdala activity and elicits fear behavior. These results unravel a sustained oscillatory mechanism mediating prefrontal-amygdala coupling during fear behavior.

  9. Long-term underwater sound measurements in the shipping noise indicator bands 63Hz and 125Hz from the port of Falmouth Bay, UK.

    PubMed

    Garrett, J K; Blondel, Ph; Godley, B J; Pikesley, S K; Witt, M J; Johanning, L

    2016-09-15

    Chronic low-frequency anthropogenic sound, such as shipping noise, may be negatively affecting marine life. The EU's Marine Strategy Framework Directive (MSFD) includes a specific indicator focused on this noise. This indicator is the yearly average sound level in third-octave bands with centre frequencies at 63Hz and 125Hz. These levels are described for Falmouth Bay, UK, an active port at the entrance to the English Channel. Underwater sound was recorded for 30min h(-1) over the period June 2012 to November 2013 for a total of 435days. Mean third-octave levels were louder in the 125-Hz band (annual mean level of 96.0dB re 1μPa) than in the 63-Hz band (92.6dB re 1 μPa). These levels and variations are assessed as a function of seasons, shipping activity and wave height, providing comparison points for future monitoring activities, including the MSFD and emerging international regulation.

  10. Long-term underwater sound measurements in the shipping noise indicator bands 63Hz and 125Hz from the port of Falmouth Bay, UK.

    PubMed

    Garrett, J K; Blondel, Ph; Godley, B J; Pikesley, S K; Witt, M J; Johanning, L

    2016-09-15

    Chronic low-frequency anthropogenic sound, such as shipping noise, may be negatively affecting marine life. The EU's Marine Strategy Framework Directive (MSFD) includes a specific indicator focused on this noise. This indicator is the yearly average sound level in third-octave bands with centre frequencies at 63Hz and 125Hz. These levels are described for Falmouth Bay, UK, an active port at the entrance to the English Channel. Underwater sound was recorded for 30min h(-1) over the period June 2012 to November 2013 for a total of 435days. Mean third-octave levels were louder in the 125-Hz band (annual mean level of 96.0dB re 1μPa) than in the 63-Hz band (92.6dB re 1 μPa). These levels and variations are assessed as a function of seasons, shipping activity and wave height, providing comparison points for future monitoring activities, including the MSFD and emerging international regulation. PMID:27393210

  11. fine structure of 410km discontinuity beneath the Southern Europe

    NASA Astrophysics Data System (ADS)

    Wan, K.; Wan, X.; Ni, S.

    2005-12-01

    In the distance range of 10-14 degrees, P waves from the topside reflection off the 410km discontinuity are very sensitive to the fine structure of the discontinuity. We analyzed 49 broadband seismograms from an earthquake ( May 18, 1998) in Italy (Mw 5.8) , recorded by Orfeus and SZGRF networks. Distances between the source and the stations were from 9° to 19°, and provided a detailed look at the 410km structure. On the other hand, the azimuth of these records were in a narrow range from 334° and 356°, so the differences in azimuth may have little effects on the waveforms. From our observation, P410 phase has little change in amplitude when the distance decreases from 15° to about 11.5°. However, an abrupt termination was observed from distance 11° to 10.5°. These features cannot be explained with PREM model. We calculated several groups of models with F-K method and compared their synthetic seismograms with the observed one. These models are: 1) two-step sharp jump models, with different thickness; 2) linear models; 3) linear-sharp jump models[Tim Melbourne, Don Helmberger, Journal of Geophysical Research, 1998]; 4) models calculated from a mineralogical model[Gaherty, Wang, Geophysical research letters, 1999]; Features in the observed waveform can be well modeled with model 3 and 4 while only parts of them fitted to model 1 or 2. But when we calculated with a less detailed model, seismograms of model 4 should have more noise than model 3. In conclusion, the structure of 410km discontinuity can be considered as a linear-sharp velocity jump, which is consistent with mineralogical models.

  12. Safety of ipsapirone treatment compared with lorazepam: discontinuation effects.

    PubMed Central

    Busto, U E; Naranjo, C A; Bremner, K E; Peachey, J E; Bologa, M

    1998-01-01

    OBJECTIVE: To determine discontinuation effects of ipsapirone, a novel azapirone and partial 5-HTIA agonist that has anxiolytic effects clinically and has not caused dependence or withdrawal symptoms in animals, and to compare these effects with those of the benzodiazepine lorazepam, owing to concern about dependence or withdrawal symptoms following use of these drugs. DESIGN: Prospective, randomized, double-blind, placebo-controlled trial. SETTING: Outpatient and inpatient treatment. PARTICIPANTS: Sixty-five healthy male volunteers who had experience with sedative-hypnotics or anxiolytics and did not meet DSM-III-R criteria for abuse or dependence. INTERVENTIONS: Participants were randomized to receive ipsapirone 15 mg per day (n = 17), ipsapirone 22.5 mg per day (n = 16), lorazepam 3 mg per day (n = 16), or placebo (n = 16) as outpatients for 36 days (treatment) followed by single-blind placebo as inpatients for 3 days and as outpatients for 6 days (withdrawal). OUTCOME MEASURES: Hamilton Anxiety Rating Scale (HAM-A), Hamilton Depression Scale (HAM-D), Spielberger State Anxiety Scale, Sleep Quality Questionnaire, General Symptom Checklist, self-rated intoxication, Clinical Institute Withdrawal Assessment--Benzodiazepines (CIWA-Benzo), psychomotor testing and urine drug screen. RESULTS: Only 45 subjects completed the study; discontinuation rates did not significantly differ among treatment groups. At day 39, fewer and less severe symptoms (e.g., insomnia and fatigue) were found on the CIWA-Benzo scale after treatment with ipsapirone or placebo than after treatment with lorazepam (p < 0.05). Subjects reported longer sleep latency and poorer sleep quality after receiving lorazepam than after receiving ipsapirone or placebo. Scores on the HAM-D, Spielberger State Anxiety and HAM-A scales did not change from baseline. CONCLUSIONS: Withdrawal symptoms were detected after discontinuation of therapeutic doses of lorazepam. Significantly fewer symptoms were observed after

  13. Comparison of continuous and discontinuous discretizations for the Stokes flow

    NASA Astrophysics Data System (ADS)

    Lehmann, Ragnar; Kaus, Boris J. P.; Lukáčová-Medvid'ová, Maria

    2013-04-01

    Finite element methods (FEM) of various types are widely used to solve incompressible flow problems in general and Stokes flow in particular. We present first results of a study comparing two numerical methods: the continuous Galerkin and the discontinuous Galerkin (DG) method. For this purpose a Matlab code was developed employing 2D Stokes flow in a model setup with known analytical solution. [2] Nonlinearities of, e.g., the viscosity can lead to discontinuities in the velocity-pressure solution. Hence, using continuous approximations may result in avoidable inaccuracies. In contrast to the FEM, the DG method allows for discontinuities of velocity and pressure across interior mesh edges. This increases the number of degrees of freedom by a constant factor depending on the chosen element. A parameter is introduced to penalize the jumps in the velocity. The DG method provides the capability to locally adapt the polynomial degree of the shape functions. Moreover, it only needs communication between directly adjacent mesh cells, which makes it highly flexible and easy to parallelize. The velocity and pressure errors of the methods are measured in the L1-norm [1]. Orders of convergence are determined and compared. [1] Duretz, T., May, D.A., Garya, T.V. and Tackley, P.J., 2011. Discretization errors and free surface stabilization in the finite difference and marker-in-cell method for applied geodynamics: A numerical Study, Geochem. Geophys. Geosyst., 12, Q07004, doi:10.1029/2011GC003567. [2] Zhong, S., 1996. Analytic solution for Stokes' flow with lateral variations in viscosity, Geophys. J. Int., 124, 18-128, doi:10.1111/j.1365-246X.1996.tb06349.x.

  14. Discontinuous Spectral Difference Method for Conservation Laws on Unstructured Grids

    NASA Technical Reports Server (NTRS)

    Liu, Yen; Vinokur, Marcel

    2004-01-01

    A new, high-order, conservative, and efficient discontinuous spectral finite difference (SD) method for conservation laws on unstructured grids is developed. The concept of discontinuous and high-order local representations to achieve conservation and high accuracy is utilized in a manner similar to the Discontinuous Galerkin (DG) and the Spectral Volume (SV) methods, but while these methods are based on the integrated forms of the equations, the new method is based on the differential form to attain a simpler formulation and higher efficiency. Conventional unstructured finite-difference and finite-volume methods require data reconstruction based on the least-squares formulation using neighboring point or cell data. Since each unknown employs a different stencil, one must repeat the least-squares inversion for every point or cell at each time step, or to store the inversion coefficients. In a high-order, three-dimensional computation, the former would involve impractically large CPU time, while for the latter the memory requirement becomes prohibitive. In addition, the finite-difference method does not satisfy the integral conservation in general. By contrast, the DG and SV methods employ a local, universal reconstruction of a given order of accuracy in each cell in terms of internally defined conservative unknowns. Since the solution is discontinuous across cell boundaries, a Riemann solver is necessary to evaluate boundary flux terms and maintain conservation. In the DG method, a Galerkin finite-element method is employed to update the nodal unknowns within each cell. This requires the inversion of a mass matrix, and the use of quadratures of twice the order of accuracy of the reconstruction to evaluate the surface integrals and additional volume integrals for nonlinear flux functions. In the SV method, the integral conservation law is used to update volume averages over subcells defined by a geometrically similar partition of each grid cell. As the order of

  15. Discontinued drug projects in the respiratory therapeutic area during 2012.

    PubMed

    Snell, Noel J C

    2014-03-01

    During 2012, a number of respiratory drug projects and individual agents were discontinued, for a variety of reasons, including toxicity, lack of efficacy, commercial re-evaluation and change in corporate focus. These included three antagonists of chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTh2), which had been evaluated in allergic respiratory disease and (in one case) chronic obstructive pulmonary disease (COPD), and other agents intended for the treatment of asthma, COPD, pulmonary hypertension and lung fibrosis. These have been reviewed against the background of a general reduction in respiratory research by the pharmaceutical industry.

  16. Cryogenic thermal storage system for discontinuous industrial vacuum processes

    NASA Astrophysics Data System (ADS)

    Bruzzi, M.; Chesi, A.; Baldi, A.; Tarani, F.; Mori, R.; Scaringella, M.; Carnevale, E.

    2012-10-01

    Phase Change Materials are proposed for refrigerating systems in discontinuous industrial vacuum processes where temperatures as low as -140 ÷ -100°C are necessary within time-frames representing 10÷20% of total operating time. An application is proposed for cooling systems used in a Physical Vapour Deposition (PVD) apparatus. A prototype has been manufactured which couples a cryopump with a reservoir filled with MethylCycloPentane (MCP-C6H12) and a distribution line where nitrogen in the gaseous state is flowing. Preliminary tests show that temperatures of about -120°C are actually achieved within time windows compatible with PVD applications.

  17. Advanced shear-lag model applicable to discontinuous fiber composites

    SciTech Connect

    Fukuda, H.; Chou, T.W.

    1981-01-01

    An analysis for predicting the stress distribution in unidirectional discontinuous fiber composites has been developed and is reported herein. Although the basic approach is based upon the shear-lag analysis, the load transfer at fiber ends is taken into consideration. This consideration becomes important if the bonding between the fiber and matrix at the fiber end is perfect such as the cases often observed in metal matrix composites, as well as during the early stage of loading of polymeric matrix composites. The present analysis includes the ordinary shear-lag analysis as a special case. 28 references.

  18. GPU-accelerated discontinuous Galerkin methods on hybrid meshes

    NASA Astrophysics Data System (ADS)

    Chan, Jesse; Wang, Zheng; Modave, Axel; Remacle, Jean-Francois; Warburton, T.

    2016-08-01

    We present a time-explicit discontinuous Galerkin (DG) solver for the time-domain acoustic wave equation on hybrid meshes containing vertex-mapped hexahedral, wedge, pyramidal and tetrahedral elements. Discretely energy-stable formulations are presented for both Gauss-Legendre and Gauss-Legendre-Lobatto (Spectral Element) nodal bases for the hexahedron. Stable timestep restrictions for hybrid meshes are derived by bounding the spectral radius of the DG operator using order-dependent constants in trace and Markov inequalities. Computational efficiency is achieved under a combination of element-specific kernels (including new quadrature-free operators for the pyramid), multi-rate timestepping, and acceleration using Graphics Processing Units.

  19. Characterization of microstrip discontinuities in the time and frequency domains

    NASA Technical Reports Server (NTRS)

    Feldman, U.; Mittra, R.

    1985-01-01

    A number of impedance transitions and interconnections to a microstrip were designed and investigated. The double-step discontinuity on a microstrip was studied in detail, and a procedure was developed to design these structures. Their response was determined by making measurements in both the frequency and time domains in a consistent and repeatable manner. The time-domain presentation of the data was the most useful feature of the measuring system. All undesirable signal components were filtered out through the use of gating functions. Theoretically computed results were verified experimentally.

  20. Superior mesenteric artery thrombosis after abrupt discontinuation of rivaroxaban.

    PubMed

    Adams, Christopher B; Acquisto, Nicole M; Rotoli, Jason M; LoStracco, Thomas; Shamaskin, Ann R; Pasternack, Joel S

    2016-04-01

    We report a case of superior mesenteric artery thrombosis after the abrupt discontinuation of rivaroxaban in a 59-year-old male patient. The initial presentation was of sudden onset abdominal pain, nausea, vomiting, diarrhea, and hematochezia in the setting of recently holding rivaroxaban anticoagulation for an atrial flutter ablative procedure. Imaging revealed thrombosis of the superior mesenteric artery and acute mesenteric ischemia requiring emergent surgical intervention for embolectomy. Upon exploratory laparotomy, the bowel was found to be viable, and an embolectomy with patch angioplasty was successful without complication. This case illustrates the need for emergency medicine clinician familiarity with this possible medication adverse event with rivaroxaban.

  1. Continuous and Discontinuous Dynamic Unbinding Transitions in Drawn Film Flow

    NASA Astrophysics Data System (ADS)

    Galvagno, M.; Tseluiko, D.; Lopez, H.; Thiele, U.

    2014-04-01

    When a plate is withdrawn from a liquid bath a coating layer is deposited whose thickness and homogeneity depend on the velocity and the wetting properties of the plate. Using a long-wave mesoscopic hydrodynamic description that incorporates wettability via a Derjaguin (disjoining) pressure we identify four qualitatively different dynamic transitions between microscopic and macroscopic coatings that are out-of-equilibrium equivalents of known equilibrium unbinding transitions. Namely, these are continuous and discontinuous dynamic wetting and emptying transitions. Several of their features have no equivalent at equilibrium.

  2. BIOVENTING - Groundwater Aeration by Discontinuous Oxygen Gas Pulse Injections

    NASA Astrophysics Data System (ADS)

    Schirmer, M.

    2003-12-01

    Groundwater aeration by discontinuous oxygen gas pulse injections appears to be a promising concept for enhanced natural attenuation of dissolved contaminants that are susceptible for oxygenase enzyme attacks. Oxygen amendments facilitate indigenous microbiota to catabolize groundwater pollutants, such as aromatics, that are considered to be recalcitrant in absence of dissolved oxygen. As a rule, natural attenuation of many pollutants under aerobic conditions is considerably faster than under anaerobic conditions. Thus, enhancing the dissolved oxygen level appears to be worthwhile. In situ aeration of groundwater has been accomplished by air sparging, H2O2-supply, or by utilization of oxygen release compounds. However, continuous aeration of previously anaerobic groundwater is not desirable for several reasons: (a) economic efforts too high, (b) pollutant dislocation towards surface (desired only in air sparging), (c) risk of aquifer clogging (gas clogging, oxidation of ferrous iron, formation of bioslimes). In contrast, discontinuous oxygen gas sparging provides only for periodical groundwater aeration which is followed by microaerobic and suboxic conditions. Microaerobic conditions can prevail spatially (e.g., at plume fringes or within biofilms) or temporarily (e.g., at discontinuous bioventing). They still allow adapted bacteria to transform environmental pollutants to less toxic compounds, e.g., aromatic ring cleavage after dioxygenasis attack. Ring cleavage products, on the other hand, may be degraded more easily by anaerobic consortia than the initial aromatic compounds, making oxygen depletion periods highly intriguing in regard to an initiation of natural attenuation processes at plume fringes. In our work we outline the effect of oxygen depletion conditions on biodegradation of monchlorobenzene (MCB) as they occur subsequently to temporary aeration periods. For microaerobic conditions, relative to the oxygen supply, a stoichiometric transformation of MCB

  3. Local Analysis of Shock Capturing Using Discontinuous Galerkin Methodology

    NASA Technical Reports Server (NTRS)

    Atkins, H. L.

    1997-01-01

    The compact form of the discontinuous Galerkin method allows for a detailed local analysis of the method in the neighborhood of the shock for a non-linear model problem. Insight gained from the analysis leads to new flux formulas that are stable and that preserve the compactness of the method. Although developed for a model equation, the flux formulas are applicable to systems such as the Euler equations. This article presents the analysis for methods with a degree up to 5. The analysis is accompanied by supporting numerical experiments using Burgers' equation and the Euler equations.

  4. Acoustic Scattering in Flexible Waveguide Involving Step Discontinuity

    PubMed Central

    Afzal, Muhammad; Nawaz, Rab; Ayub, Muhammad; Wahab, Abdul

    2014-01-01

    In this paper, the propagation and scattering of acoustic waves in a flexible wave-guide involving step discontinuity at an interface is considered. The emerging boundary value problem is non-Sturm-Liouville and is solved by employing a hybrid mode-matching technique. The physical scattering process and attenuation of duct modes versus frequency regime and change of height is studied. Moreover, the mode-matching solution is validated through a series of numerical experiments by testifying the power conservation identity and matching interface conditions. PMID:25084019

  5. Simulating diffusion processes in discontinuous media: Benchmark tests

    NASA Astrophysics Data System (ADS)

    Lejay, Antoine; Pichot, Géraldine

    2016-06-01

    We present several benchmark tests for Monte Carlo methods simulating diffusion in one-dimensional discontinuous media. These benchmark tests aim at studying the potential bias of the schemes and their impact on the estimation of micro- or macroscopic quantities (repartition of masses, fluxes, mean residence time, …). These benchmark tests are backed by a statistical analysis to filter out the bias from the unavoidable Monte Carlo error. We apply them on four different algorithms. The results of the numerical tests give a valuable insight into the fine behavior of these schemes, as well as rules to choose between them.

  6. 5 Hz, >250 mJ Optical Parametric Chirped-Pulse Amplifier at 1053 nm

    SciTech Connect

    Bagnoud, V.; Begishev, I.A.; Guardalben, M.J.; Puth, J.; Zuegel, J.D.

    2005-07-15

    A 250 mJ, 5 Hz repetition rate optical parametric chirped-pulse amplifier with near-Fourier-transform-limited, 430 fs pulses and a beam that can be focused to near the diffraction limit is demonstrated.

  7. Effects of 60 Hz electric fields on operant and social stress behaviors of nonhuman primates

    SciTech Connect

    Rogers, W.R.; Lucas, J.H.; Moore, G.T.; Orr, J.L.

    1985-01-01

    An overall description of this research program is presented. The objectives are to investigate using nonhuman primates, possible behavioral effects associated with exposure to high-intensity, 60 Hz, electric fields. 6 tabs.

  8. Aging and the 4-kHz Air-Bone Gap

    ERIC Educational Resources Information Center

    Nondahl, David M.; Tweed, Ted S.; Cruickshanks, Karen J.; Wiley, Terry L.; Dalton, Dayna S.

    2012-01-01

    Purpose: In this study, the authors assessed age- and sex-related patterns in the prevalence and 10-year incidence of 4-kHz air-bone gaps and associated factors. Method: Data were obtained as part of the longitudinal, population-based Epidemiology of Hearing Loss Study ( Cruickshanks et al., 1998). An air-bone gap at 4 kHz was defined as an…

  9. The Modified HZ Conjugate Gradient Algorithm for Large-Scale Nonsmooth Optimization

    PubMed Central

    Yuan, Gonglin; Sheng, Zhou; Liu, Wenjie

    2016-01-01

    In this paper, the Hager and Zhang (HZ) conjugate gradient (CG) method and the modified HZ (MHZ) CG method are presented for large-scale nonsmooth convex minimization. Under some mild conditions, convergent results of the proposed methods are established. Numerical results show that the presented methods can be better efficiency for large-scale nonsmooth problems, and several problems are tested (with the maximum dimensions to 100,000 variables). PMID:27780245

  10. Regulation causes nitrogen cycling discontinuities in Mediterranean rivers.

    PubMed

    von Schiller, Daniel; Aristi, Ibon; Ponsatí, Lídia; Arroita, Maite; Acuña, Vicenç; Elosegi, Arturo; Sabater, Sergi

    2016-01-01

    River regulation has fundamentally altered large sections of the world's river networks. The effects of dams on the structural properties of downstream reaches are well documented, but less is known about their effect on river ecosystem processes. We investigated the effect of dams on river nutrient cycling by comparing net uptake of total dissolved nitrogen (TDN), phosphorus (TDP) and organic carbon (DOC) in river reaches located upstream and downstream from three reservoir systems in the Ebro River basin (NE Iberian Peninsula). Increased hydromorphological stability, organic matter standing stocks and ecosystem metabolism below dams enhanced the whole-reach net uptake of TDN, but not that of TDP or DOC. Upstream from dams, river reaches tended to be at biogeochemical equilibrium (uptake≈release) for all nutrients, whereas river reaches below dams acted as net sinks of TDN. Overall, our results suggest that flow regulation by dams may cause relevant N cycling discontinuities in rivers. Higher net N uptake capacity below dams could lead to reduced N export to downstream ecosystems. Incorporating these discontinuities could significantly improve predictive models of N cycling and transport in complex river networks. PMID:26233271

  11. Hollow cylindrical plasma filament waveguide with discontinuous finite thickness cladding

    SciTech Connect

    Alshershby, Mostafa; Hao Zuoqiang; Lin Jingquan

    2013-01-15

    We have explored here a hollow cylindrical laser plasma multifilament waveguide with discontinuous finite thickness cladding, in which the separation between individual filaments is in the range of several millimeters and the waveguide cladding thickness is in the order of the microwave penetration depth. Such parameters give a closer representation of a realistic laser filament waveguide sustained by a long stable propagation of femtosecond (fs) laser pulses. We report how the waveguide losses depend on structural parameters like normalized plasma filament spacing, filament to filament distance or pitch, normal spatial frequency, and radius of the plasma filament. We found that for typical plasma parameters, the proposed waveguide can support guided modes of microwaves in extremely high frequency even with a cladding consisting of only one ring of plasma filaments. The loss of the microwave radiation is mainly caused by tunneling through the discontinuous finite cladding, i.e., confinement loss, and is weakly dependent on the plasma absorption. In addition, the analysis indicates that the propagation loss is fairly large compared with the loss of a plasma waveguide with a continuous infinite thickness cladding, while they are comparable when using a cladding contains more than one ring. Compared to free space propagation, this waveguide still presents a superior microwave transmission to some distance in the order of the filamentation length; thus, the laser plasma filaments waveguide may be a potential channel for transporting pulsed-modulated microwaves if ensuring a long and stable propagation of fs laser pulses.

  12. Asymptotic, multigroup flux reconstruction and consistent discontinuity factors

    SciTech Connect

    Trahan, Travis J.; Larsen, Edward W.

    2015-05-12

    Recent theoretical work has led to an asymptotically derived expression for reconstructing the neutron flux from lattice functions and multigroup diffusion solutions. The leading-order asymptotic term is the standard expression for flux reconstruction, i.e., it is the product of a shape function, obtained through a lattice calculation, and the multigroup diffusion solution. The first-order asymptotic correction term is significant only where the gradient of the diffusion solution is not small. Inclusion of this first-order correction term can significantly improve the accuracy of the reconstructed flux. One may define discontinuity factors (DFs) to make certain angular moments of the reconstructed flux continuous across interfaces between assemblies in 1-D. Indeed, the standard assembly discontinuity factors make the zeroth moment (scalar flux) of the reconstructed flux continuous. The inclusion of the correction term in the flux reconstruction provides an additional degree of freedom that can be used to make two angular moments of the reconstructed flux continuous across interfaces by using current DFs in addition to flux DFs. Thus, numerical results demonstrate that using flux and current DFs together can be more accurate than using only flux DFs, and that making the second angular moment continuous can be more accurate than making the zeroth moment continuous.

  13. WITHDRAWN--a resource for withdrawn and discontinued drugs.

    PubMed

    Siramshetty, Vishal B; Nickel, Janette; Omieczynski, Christian; Gohlke, Bjoern-Oliver; Drwal, Malgorzata N; Preissner, Robert

    2016-01-01

    Post-marketing drug withdrawals can be associated with various events, ranging from safety issues such as reported deaths or severe side-effects, to a multitude of non-safety problems including lack of efficacy, manufacturing, regulatory or business issues. During the last century, the majority of drugs voluntarily withdrawn from the market or prohibited by regulatory agencies was reported to be related to adverse drug reactions. Understanding the underlying mechanisms of toxicity is of utmost importance for current and future drug discovery. Here, we present WITHDRAWN, a resource for withdrawn and discontinued drugs publicly accessible at http://cheminfo.charite.de/withdrawn. Today, the database comprises 578 withdrawn or discontinued drugs, their structures, important physico-chemical properties, protein targets and relevant signaling pathways. A special focus of the database lies on the drugs withdrawn due to adverse reactions and toxic effects. For approximately one half of the drugs in the database, safety issues were identified as the main reason for withdrawal. Withdrawal reasons were extracted from the literature and manually classified into toxicity types representing adverse effects on different organs. A special feature of the database is the presence of multiple search options which will allow systematic analyses of withdrawn drugs and their mechanisms of toxicity.

  14. Pulsations of rapidly rotating stars with compositional discontinuities

    NASA Astrophysics Data System (ADS)

    Reese, Daniel R.; Lara, Francisco Espinosa; Rieutord, Michel

    2014-02-01

    Recent observations of rapidly rotating stars have revealed the presence of regular patterns in their pulsation spectra. This has raised the question as to their physical origin, and, in particular, whether they can be explained by an asymptotic frequency formula for low-degree acoustic modes, as recently discovered through numerical calculations and theoretical considerations. In this context, a key question is whether compositional/density gradients can adversely affect such patterns to the point of hindering their identification. To answer this question, we calculate frequency spectra using two-dimensional ESTER stellar models. These models use a multi-domain spectral approach, allowing us to easily insert a compositional discontinuity while retaining a high numerical accuracy. We analyse the effects of such discontinuities on both the frequencies and eigenfunctions of pulsation modes in the asymptotic regime. We find that although there is more scatter around the asymptotic frequency formula, the semi-large frequency separation can still be clearly identified in a spectrum of low-degree acoustic modes.

  15. Regulation causes nitrogen cycling discontinuities in Mediterranean rivers.

    PubMed

    von Schiller, Daniel; Aristi, Ibon; Ponsatí, Lídia; Arroita, Maite; Acuña, Vicenç; Elosegi, Arturo; Sabater, Sergi

    2016-01-01

    River regulation has fundamentally altered large sections of the world's river networks. The effects of dams on the structural properties of downstream reaches are well documented, but less is known about their effect on river ecosystem processes. We investigated the effect of dams on river nutrient cycling by comparing net uptake of total dissolved nitrogen (TDN), phosphorus (TDP) and organic carbon (DOC) in river reaches located upstream and downstream from three reservoir systems in the Ebro River basin (NE Iberian Peninsula). Increased hydromorphological stability, organic matter standing stocks and ecosystem metabolism below dams enhanced the whole-reach net uptake of TDN, but not that of TDP or DOC. Upstream from dams, river reaches tended to be at biogeochemical equilibrium (uptake≈release) for all nutrients, whereas river reaches below dams acted as net sinks of TDN. Overall, our results suggest that flow regulation by dams may cause relevant N cycling discontinuities in rivers. Higher net N uptake capacity below dams could lead to reduced N export to downstream ecosystems. Incorporating these discontinuities could significantly improve predictive models of N cycling and transport in complex river networks.

  16. Facilitated synchronization of complex networks through a discontinuous coupling strategy

    NASA Astrophysics Data System (ADS)

    Chen, L.; Qiu, C.; Huang, H. B.; Qi, G. X.; Wang, H. J.

    2010-08-01

    Synchronization stability in complex networks is a topic of theoretical interest and practical importance. Increasing effort has been devoted to the enhancement of synchronizability of networks, or more specifically, the design of synchronizable networks. However, most previous attempts turn the coupling weight/gradient or change the topological interactions, which sometimes is not manageable. In this paper, by adopting a simple kind of discontinuous coupling strategy: the uniform on-off coupling scheme, with on-off period being comparable to the timescale of node dynamics, the problem is solved within the framework of the master stability function. The results show that, this strategy can greatly increase the stable region of synchronization, which means the size of synchronizable networks can be much larger than the traditional case, without any changes of their connections. Furthermore, the synchronization speed can be accelerated considerably, which is even higher than the previous optimal case. The mechanism of the facilitation is revealed and shows that the continuous coupling in fact is one of the worst choices for synchronization in the view of discontinuous coupling strategy. The coupling cost required for synchronization is also examined, which is approximately the same as the continuous coupling.

  17. Long discontinuous fiber composite structure: Forming and structural mechanics

    NASA Technical Reports Server (NTRS)

    Pipes, R. B.; Santare, M. H.; Otoole, B. J.; Beaussart, A. J.; Deheer, D. C.; Okine, R. K.

    1991-01-01

    Cost effective composite structure has motivated the investigation of several new approaches to develop composite structure from innovative material forms. Among the promising new approaches is the conversion of planar sheet to components of complex curvature through sheet forming or stretch forming. In both cases, the potential for material stretch in the fiber direction appears to offer a clear advantage in formability over continuous fiber systems. In the present study, the authors have established a framework which allows the simulation of the anisotropic mechanisms of deformation of long discontinuous fiber laminates wherein the matrix phase is a viscous fluid. The initial study focuses upon the establishment of micromechanics models for prediction of the effective anisotropic viscosities of the oriented fiber assembly in a viscous matrix. Next, the developed constitutive relation is employed through an analogy with incompressible elasticity to exercise the finite element technique for determination of local fiber orientation and laminate thickness after forming. Results are presented for the stretch bending of a curved beam from an arbitrary composite laminate and the bulging of a clamped sheet. Structural analyses are conducted to determine the effect of microstructure on the performance of curved beams manufactured from long discontinuous fiber composites. For the purposes of this study, several curved beams with ideal and non-ideal microstructures are compared for response under pure bending. Material parameters are determined from a separate microstructural analysis.

  18. Asymptotic, multigroup flux reconstruction and consistent discontinuity factors

    DOE PAGES

    Trahan, Travis J.; Larsen, Edward W.

    2015-05-12

    Recent theoretical work has led to an asymptotically derived expression for reconstructing the neutron flux from lattice functions and multigroup diffusion solutions. The leading-order asymptotic term is the standard expression for flux reconstruction, i.e., it is the product of a shape function, obtained through a lattice calculation, and the multigroup diffusion solution. The first-order asymptotic correction term is significant only where the gradient of the diffusion solution is not small. Inclusion of this first-order correction term can significantly improve the accuracy of the reconstructed flux. One may define discontinuity factors (DFs) to make certain angular moments of the reconstructed fluxmore » continuous across interfaces between assemblies in 1-D. Indeed, the standard assembly discontinuity factors make the zeroth moment (scalar flux) of the reconstructed flux continuous. The inclusion of the correction term in the flux reconstruction provides an additional degree of freedom that can be used to make two angular moments of the reconstructed flux continuous across interfaces by using current DFs in addition to flux DFs. Thus, numerical results demonstrate that using flux and current DFs together can be more accurate than using only flux DFs, and that making the second angular moment continuous can be more accurate than making the zeroth moment continuous.« less

  19. Optical strain for monitoring of concrete failure mechanism with discontinuity.

    PubMed

    Deb, Debasis; Bhattacharjee, Sudipta

    2015-12-10

    Finite-element-based digital image correlation (FEM-DIC) is one of the most widely used noncontact techniques in the field of experimental mechanics for measurement of deformation/strain. In this paper, the FEM-DIC method is refined by introducing the concept of multilevel extended digital image correlation (X-DIC), which also can capture deformation across discontinuity planes if they exist in images. Using regular and enhanced displacements at each node, strain tensors are estimated by applying the concept of smooth particle hydrodynamics (SPH). Numerical works are carried out to check the accuracy level of the developed algorithm by considering discrete discontinuity on the surface of a sample. Work is further extended to determine displacements and strains developed at the surface of several cubical concrete samples under uniaxial loading conditions. The tests are conducted until fractures are developed in the post-failure region. Using the concept of cumulative effective strain, a parameter is identified, which can be used as a precursor in the object failure process.

  20. Investigations of discontinuous permafrost using electrical resistivity tomography

    NASA Astrophysics Data System (ADS)

    Lewkowicz, Antoni

    2016-04-01

    We have used electrical resistivity tomography (ERT) extensively over the past five years to examine frozen ground characteristics at natural and disturbed sites within the discontinuous permafrost zones of northern Canada. Examples of pure research include investigations to delimit permafrost patch size, to examine changes in permafrost conditions at altitudinal treeline, and to assess permafrost thickness in palsa bogs. Applied research has included hazard mapping where ERT, in association with boreholes, has been used to characterize permafrost conditions in different terrain units at Yukon communities as part of planning for climate change adaptation. ERT has also been used to examine temporal change through repeated surveys at sites equipped with permanent arrays. Rapid change is occurring at sites which were subject to recent forest fire in the Northwest Territories. Gradual reductions in average resistivity at sites along the Alaska Highway in Yukon and northern British Columbia indicate progressive increases in unfrozen moisture while ground temperatures at the same sites have increased only very slightly. We conclude that ERT should become a standard technique for the investigation of discontinuous permafrost sites and should be incorporated as a monitoring technique within international programs such as the Global Terrestrial Network for Permafrost.

  1. Pipeline integrity design for differential settlement in discontinuous permafrost areas

    SciTech Connect

    Zhou, Z.J.; Boivin, R.P.; Glover, A.G.; Kormann, P.J.

    1996-12-31

    The NOVA Gas Transmission Ltd. (NGTL) gas pipeline system is expanding northwards as the producers search for and find new gas reserves. This growth has taken the system into the discontinuous permafrost zone, and also into new design problems. One such problem is the structural integrity of a pipeline subjected to the settlement differentials that occur between frozen and unfrozen soils. Adequate integrity design for differential settlement is required by design codes, such as CSA Z662, but the procedures and criteria must be established by the pipeline designers. This paper presents the methodology of pipeline integrity design for differential settlements used on a number of pipeline projects in Northwest Alberta. Outlined in the paper are the procedures, rationales and models used to: (a) locate discontinuous permafrost; (b) quantify the potential differential settlement; (c) predict pipeline stresses and strains; (d) establish strain limits; and (e) determine the pipe wall thickness to withstand those potential differential settlements. Several design options are available and are briefly discussed. For the projects mentioned, the heavy wall pipe option was identified as a cost effective design for medium to large differential settlements.

  2. Discontinuity detection in multivariate space for stochastic simulations

    SciTech Connect

    Archibald, Rick Gelb, Anne Saxena, Rishu Xiu Dongbin

    2009-04-20

    Edge detection has traditionally been associated with detecting physical space jump discontinuities in one dimension, e.g. seismic signals, and two dimensions, e.g. digital images. Hence most of the research on edge detection algorithms is restricted to these contexts. High dimension edge detection can be of significant importance, however. For instance, stochastic variants of classical differential equations not only have variables in space/time dimensions, but additional dimensions are often introduced to the problem by the nature of the random inputs. The stochastic solutions to such problems sometimes contain discontinuities in the corresponding random space and a prior knowledge of jump locations can be very helpful in increasing the accuracy of the final solution. Traditional edge detection methods typically require uniform grid point distribution. They also often involve the computation of gradients and/or Laplacians, which can become very complicated to compute as the number of dimensions increases. The polynomial annihilation edge detection method, on the other hand, is more flexible in terms of its geometric specifications and is furthermore relatively easy to apply. This paper discusses the numerical implementation of the polynomial annihilation edge detection method to high dimensional functions that arise when solving stochastic partial differential equations.

  3. Discontinuity Detection in Multivariate Space for Stochastic Simulations

    SciTech Connect

    Archibald, Richard K; Gelb, Anne; Saxena, Rishu; Xiu, Dongbin

    2009-01-01

    Edge detection has traditionally been associated with detecting physical space jump discontinuities in one dimension, e.g. seismic signals, and two dimensions, e.g. digital images. Hence most of the research on edge detection algorithms is restricted to these contexts. High dimension edge detection can be of significant importance, however. For instance, stochastic variants of classical differential equations not only have variables in space/time dimensions, but additional dimensions are often introduced to the problem by the nature of the random inputs. The stochastic solutions to such problems sometimes contain discontinuities in the corresponding random space and a prior knowledge of jump locations can be very helpful in increasing the accuracy of the final solution. Traditional edge detection methods typically require uniform grid point distribution. They also often involve the computation of gradients and/or Laplacians, which can become very complicated to compute as the number of dimensions increases. The polynomial annihilation edge detection method, on the other hand, is more flexible in terms of its geometric specifications and is furthermore relatively easy to apply. This paper discusses the numerical implementation of the polynomial annihilation edge detection method to high dimensional functions that arise when solving stochastic partial differential equations.

  4. Mantle transition zone discontinuities beneath the contiguous United States

    NASA Astrophysics Data System (ADS)

    Gao, Stephen S.; Liu, Kelly H.

    2014-08-01

    Using over 310,000 high-quality radial receiver functions recorded by the USArray and other seismic stations in the contiguous United States, the depths of the 410 km and 660 km discontinuities (d410 and d660) are mapped in over 1,000 consecutive overlapping circles with a radius of 1°. The average mantle transition zone (MTZ) thickness for both the western and central/eastern U.S. is within 3 km from the global average of 250 km, suggesting an overall normal MTZ temperature beneath both areas. The Pacific Coast Ranges and the southern Basin and Range Province are underlain by a depressed d410, indicating higher-than-normal temperature in the upper MTZ. The proposed Yellowstone and Raton hot spots are not associated with clear undulations of the MTZ discontinuities, but d410 beneath another proposed hot spot, Bermuda, is depressed significantly and d660 has a normal depth. Low-temperature regions are found in the upper MTZ associated with the subducted Juan de Fuca slab beneath the northern Rocky Mountains and in two circular areas beneath the northern Basin and Range Province and the southern Colorado Plateau. Part of the Great Plains is characterized by a depressed d660. This observation, when combined with results from seismic tomography, suggests the existence of a cold region in the lower MTZ, probably associated with subducted Farallon slab segments.

  5. WITHDRAWN—a resource for withdrawn and discontinued drugs

    PubMed Central

    Siramshetty, Vishal B.; Nickel, Janette; Omieczynski, Christian; Gohlke, Bjoern-Oliver; Drwal, Malgorzata N.; Preissner, Robert

    2016-01-01

    Post-marketing drug withdrawals can be associated with various events, ranging from safety issues such as reported deaths or severe side-effects, to a multitude of non-safety problems including lack of efficacy, manufacturing, regulatory or business issues. During the last century, the majority of drugs voluntarily withdrawn from the market or prohibited by regulatory agencies was reported to be related to adverse drug reactions. Understanding the underlying mechanisms of toxicity is of utmost importance for current and future drug discovery. Here, we present WITHDRAWN, a resource for withdrawn and discontinued drugs publicly accessible at http://cheminfo.charite.de/withdrawn. Today, the database comprises 578 withdrawn or discontinued drugs, their structures, important physico-chemical properties, protein targets and relevant signaling pathways. A special focus of the database lies on the drugs withdrawn due to adverse reactions and toxic effects. For approximately one half of the drugs in the database, safety issues were identified as the main reason for withdrawal. Withdrawal reasons were extracted from the literature and manually classified into toxicity types representing adverse effects on different organs. A special feature of the database is the presence of multiple search options which will allow systematic analyses of withdrawn drugs and their mechanisms of toxicity. PMID:26553801

  6. Two degree discontinuity as explained by boundary mixing

    SciTech Connect

    Minster, J.F.

    1985-09-20

    A three dimensional description of the two-degree discontinuity (TDD) in the North Atlantic western basin is made from the TTO and 1981 North Atlantic section data. In 1981 this break in the Theta-S slope of the Atlantic deep waters is found at Theta = 1.90/sup 0/C, S = 34.895 per thousand, near the western flank of the basin, and it seems to follow an isopycnal at sigma = 45.89 per thousand. It encounters the western boundary at the level of the Western Boundary Undercurrent (WBUC). Based on nutrient data, the TDD is more sharply defined along the western flank of the basin than along the Mid-Atlantic Ridge, where the TDD water is fresher and colder and where one finds more Antarctic Bottom Water (AABW) above the discontinuity. The TDD is consistent with vertical mixing being dominantly a boundary process: along the western flank of the basin, upward mixing of AABW is stopped at the WBUC level by the strong southward flow of North Atlantic Deep Water (NADW). Along the ridge, boundary mixing allows AABW to mix upward with waters from shallower levels. 22 references, 9 figures, 2 tables.

  7. Effective mass discontinuity and current oscillations in stratified systems

    NASA Astrophysics Data System (ADS)

    Halilov, S.; Mil'shtein, S.

    2015-11-01

    Tunnelling transport in modulated film, which occurs either stoichiometrically or due to a stress field, is analysed in terms of the variable carrier effective mass tensor. It is shown that the mass tensor discontinuity alone, i.e. with no actual potential barrier present, may lead to current oscillations versus the size of the modulated region. While both effects of mass discontinuity and the band offset upon the carrier flow are formally described in terms of wave mechanics, their mechanisms are quite distinct: the magnitude of the current oscillations due to mass disruption is determined by the differential mass across the interface, i.e. by change in the covalency due to structural modulation, whereas the band offset is generally an effect of the affinity change across the interface. Both effects are superimposed by the 3D kinematic coupling of the orthogonal transport, either constructively or destructively, leading to an oscillatory dependence of the current magnitude on the film dimension. As an illustration, the analysis is applied to a Si1-x Ge x /Si stratified structure to demonstrate the effect of quasi-bound states on the transport. The modelling is corroborated by a device simulation of a SiGe system in a heterojunction bipolar transistor setting. The findings can be used as a general method to control anisotropic tunnelling transport in stratified structures.

  8. Coupling impedances of small discontinuities: Dependence on beam velocity

    NASA Astrophysics Data System (ADS)

    Kurennoy, Sergey S.

    2006-05-01

    The beam coupling impedances of small discontinuities of an accelerator vacuum chamber have been calculated [e.g., Kurennoy, Gluckstern, and Stupakov, Phys. Rev. E 52, 4354 (1995)PLEEE81063-651X10.1103/PhysRevE.52.4354] for ultrarelativistic beams using the Bethe diffraction theory. Here we extend the results to an arbitrary beam velocity. The vacuum chamber is assumed to have an arbitrary, but uniform along the beam path, cross section. The longitudinal and transverse coupling impedances are derived in terms of series over cross-section eigenfunctions, while the discontinuity shape enters via its polarizabilities. Simple explicit formulas for two important particular cases—circular and rectangular chamber cross sections—are presented. The impedance dependence on the beam velocity exhibits some unusual features: for example, the reactive impedance, which dominates in the ultrarelativistic limit, can vanish at a certain beam velocity, or its magnitude can exceed the ultrarelativistic value many times. In addition, we demonstrate that the same technique, the field expansion into a series of cross-section eigenfunctions, is convenient for calculating the space-charge impedance of uniform beam pipes with arbitrary cross section.

  9. Anticipatory 50 kHz ultrasonic vocalizations are associated with escalated alcohol intake in dependent rats

    PubMed Central

    Buck, Cara L.; Malavar, Jordan C.; George, Olivier; Koob, George F.; Vendruscolo, Leandro F.

    2014-01-01

    Rats emit 50 kHz ultrasonic vocalizations (USVs) in situations of increased motivation, such as during the anticipation of palatable food or drugs of abuse. Whether the same holds true for the anticipation of alcohol intake remains unknown. Alcohol drinking in a nondependent state is thought to be mediated by its rewarding effects (positive reinforcement), whereas drinking in the dependent state is motivated by alcohol’s stress-relieving effects (negative reinforcement). Here, we measured context-elicited 50 kHz USVs in alcohol-dependent (alcohol vapor-exposed) and nondependent rats immediately before operant alcohol self-administration sessions. Dependent rats showed escalated levels of alcohol intake compared with nondependent rats. Overall, dependent and nondependent rats showed similar levels of anticipatory 50 kHz USVs. However, the number of anticipatory USVs was positively correlated with alcohol intake in dependent rats but not nondependent rats. Additionally, dependent rats with higher alcohol intake displayed increased anticipatory 50 kHz USVs compared with rats that had lower alcohol intake, whereas no difference was observed between rats with high and low alcohol intake in the nondependent group. Increased 50 kHz USVs were specific for the anticipation of alcohol self-administration and did not generalize to a novel environment. These findings suggest that anticipatory 50 kHz USVs may be an indicator of context-elicited negative reinforcement learning. PMID:24914463

  10. An extrasolar extreme-ultraviolet object. II - The nature of HZ 43. [hot white dwarf star

    NASA Technical Reports Server (NTRS)

    Margon, B.; Liebert, J.; Lampton, M.; Spinrad, H.; Bowyer, S.; Gatewood, G.

    1976-01-01

    A variety of data are presented concerning the spectrum, distance, temperature, and evolutionary state of the hot white dwarf HZ 43, the first extrasolar object to be detected in the EUV band. The data include spectrophotometry of the star and its red dwarf companion (HZ 43B), a trigonometric parallax for the star, its tangential velocity, and results of soft X-ray and EUV observations. The main conclusions are that: (1) the spectrum of HZ 43A is that of a hot DAwk star, (2) HZ 43B is a dM3.5e star, (3) the distance of the system is about 65 pc, (4) the tangential velocity is not atypical of white dwarfs, and (5) the stellar energy distribution of HZ 43A is well fitted by a black body with an effective temperature of approximately 110,000 K. Evolutionary implications of the existence of an object as hot as HZ 43A are briefly considered, and it is suggested that the progenitors of hot DA stars must include objects hotter than spectral type sdB, with logical possibilities being nuclei of planetary nebulae and sdO stars.

  11. Wave field features of shallow vertical discontinuity and their application in non-destructive detection

    USGS Publications Warehouse

    Liu, J.; Xia, J.; Luo, Y.; Chen, C.; Li, X.; Huang, Y.

    2007-01-01

    The geotechnical integrity of critical infrastructure can be seriously compromised by the presence of fractures or crevices. Non-destructive techniques to accurately detect fractures in critical infrastructure such as dams and highways could be of significant benefit to the geotechnical industry. This paper investigates the application of shallow seismic and georadar methods to the detection of a vertical discontinuity using numerical simulations. The objective is to address the kinematical analysis of a vertical discontinuity, determine the resulting wave field characteristics, and provide the basis for determining the existence of vertical discontinuities based on the recorded signals. Simulation results demonstrate that: (1) A reflection from a vertical discontinuity produces a hyperbolic feature on a seismic or georadar profile; (2) In order for a reflection from a vertical discontinuity to be produced, a reflecting horizon below the discontinuity must exist, the offset between source and receiver (x0) must be non-zero, on the same side of the vertical discontinuity; (3) The range of distances from the vertical discontinuity where a reflection event is observed is proportional to its length and to x0; (4) Should the vertical crevice (or fracture) pass through a reflecting horizon, dual hyperbolic features can be observed on the records, and this can be used as a determining factor that the vertical crevice passes through the interface; and (5) diffractions from the edges of the discontinuity can be recorded with relatively smaller amplitude than reflections and their ranges are not constrained by the length of discontinuity. If the length of discontinuity is short enough, diffractions are the dominant feature. Real-world examples show that the shallow seismic reflection method and the georadar method are capable of recording the hyperbolic feature, which can be interpreted as vertical discontinuity. Thus, these methods show some promise as effective non

  12. Moho depth and two discontinuities variation in Taiwan from radial teleseismic receiver functions

    NASA Astrophysics Data System (ADS)

    Ton, C.; Chen, C. H.

    2005-12-01

    In this study, we use data recorded by the stations of Broadband Array in Taiwan for Seismology (BATS) to investigate the depths of major discontinuities of the crust in Taiwan. From the differential times between direct P wave and converted Ps phase and several multiple phases on radial teleseismic receiver function, we determine the Moho depth and the Vp/Vs ratios at these stations. More importantly, we develop a method which can let us use more seismic phases to examine other discontinuities in the crust. Using the arrival times of some specific phases on radial teleseismic receiver function, except for Moho discontinuity, we found that there are two discontinuities ( denoted by discontinuity 1 and discontinuity 2 ) existing in the crust that beneath some of stations. The Moho depth in Taiwan varies from 22 to 39 km and Vp/Vs ratios varies from 1.64~1.87. The deepest Moho depth in Taiwan locates at the Central Mountain Range (CMR) and consistent with the result obtained from gravity survey. The discontinuity 1 and the discontinuity 2 exist clearly in the CMR, in the southern region and the northeastern region of Taiwan. These two discontinuities both become unapparent in the northern region (volcano region) and in the southeastern region (plate convergent area) of Taiwan. The depth of the discontinuity 1 varies from 4.5 to 11 km and while the depth of the discontinuity 2 varies from 12 to 22 km in our estimation. Based on these results, we imply that the discontinuity 1 and 2 are basement and the Conrad discontinuity respectively.

  13. 40 CFR 721.9850 - 2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9- bis[2,4,6-tris(1,1-dimethylethyl)phenoxy]-.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false 2,4,8,10-Tetraoxa-3,9-diphosphaspiro undecane, 3,9- bis -. 721.9850 Section 721.9850 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances...

  14. 40 CFR 721.9850 - 2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9- bis[2,4,6-tris(1,1-dimethylethyl)phenoxy]-.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false 2,4,8,10-Tetraoxa-3,9-diphosphaspiro undecane, 3,9- bis -. 721.9850 Section 721.9850 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances...

  15. 40 CFR 721.9850 - 2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9- bis[2,4,6-tris(1,1-dimethylethyl)phenoxy]-.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false 2,4,8,10-Tetraoxa-3,9-diphosphaspiro undecane, 3,9- bis -. 721.9850 Section 721.9850 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances...

  16. 40 CFR 721.9850 - 2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9- bis[2,4,6-tris(1,1-dimethylethyl)phenoxy]-.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false 2,4,8,10-Tetraoxa-3,9-diphosphaspiro undecane, 3,9- bis -. 721.9850 Section 721.9850 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances...

  17. 40 CFR 721.9850 - 2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9-bis[2,4,6-tris(1,1-dimethylethyl)phenoxy]-.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false 2,4,8,10-Tetraoxa-3,9-diphosphaspiro undecane, 3,9-bis -. 721.9850 Section 721.9850 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances...

  18. Contribution of strong discontinuities to the power spectrum of the solar wind.

    PubMed

    Borovsky, Joseph E

    2010-09-10

    Eight and a half years of magnetic field measurements (2(22) samples) from the ACE spacecraft in the solar wind at 1 A.U. are analyzed. Strong (large-rotation-angle) discontinuities in the solar wind are collected and measured. An artificial time series is created that preserves the timing and amplitudes of the discontinuities. The power spectral density of the discontinuity series is calculated and compared with the power spectral density of the solar-wind magnetic field. The strong discontinuities produce a power-law spectrum in the "inertial subrange" with a spectral index near the Kolmogorov -5/3 index. The discontinuity spectrum contains about half of the power of the full solar-wind magnetic field over this "inertial subrange." Warnings are issued about the significant contribution of discontinuities to the spectrum of the solar wind, complicating interpretation of spectral power and spectral indices.

  19. A Hyperspherical Adaptive Sparse-Grid Method for High-Dimensional Discontinuity Detection

    SciTech Connect

    Zhang, Guannan; Webster, Clayton G.; Gunzburger, Max D.; Burkardt, John V.

    2015-06-24

    This study proposes and analyzes a hyperspherical adaptive hierarchical sparse-grid method for detecting jump discontinuities of functions in high-dimensional spaces. The method is motivated by the theoretical and computational inefficiencies of well-known adaptive sparse-grid methods for discontinuity detection. Our novel approach constructs a function representation of the discontinuity hypersurface of an N-dimensional discontinuous quantity of interest, by virtue of a hyperspherical transformation. Then, a sparse-grid approximation of the transformed function is built in the hyperspherical coordinate system, whose value at each point is estimated by solving a one-dimensional discontinuity detection problem. Due to the smoothness of the hypersurface, the new technique can identify jump discontinuities with significantly reduced computational cost, compared to existing methods. In addition, hierarchical acceleration techniques are also incorporated to further reduce the overall complexity. Rigorous complexity analyses of the new method are provided as are several numerical examples that illustrate the effectiveness of the approach.

  20. BOLD fractional contribution to resting-state functional connectivity above 0.1 Hz.

    PubMed

    Chen, Jingyuan E; Glover, Gary H

    2015-02-15

    Blood oxygen level dependent (BOLD) spontaneous signals from resting-state (RS) brains have typically been characterized by low-pass filtered timeseries at frequencies ≤ 0.1 Hz, and studies of these low-frequency fluctuations have contributed exceptional understanding of the baseline functions of our brain. Very recently, emerging evidence has demonstrated that spontaneous activities may persist in higher frequency bands (even up to 0.8 Hz), while presenting less variable network patterns across the scan duration. However, as an indirect measure of neuronal activity, BOLD signal results from an inherently slow hemodynamic process, which in fact might be too slow to accommodate the observed high-frequency functional connectivity (FC). To examine whether the observed high-frequency spontaneous FC originates from BOLD contrast, we collected RS data as a function of echo time (TE). Here we focus on two specific resting state networks - the default-mode network (DMN) and executive control network (ECN), and the major findings are fourfold: (1) we observed BOLD-like linear TE-dependence in the spontaneous activity at frequency bands up to 0.5 Hz (the maximum frequency that can be resolved with TR=1s), supporting neural relevance of the RSFC at a higher frequency range; (2) conventional models of hemodynamic response functions must be modified to support resting state BOLD contrast, especially at higher frequencies; (3) there are increased fractions of non-BOLD-like contributions to the RSFC above the conventional 0.1 Hz (non-BOLD/BOLD contrast at 0.4-0.5 Hz is ~4 times that at <0.1 Hz); and (4) the spatial patterns of RSFC are frequency-dependent. Possible mechanisms underlying the present findings and technical concerns regarding RSFC above 0.1 Hz are discussed.