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  1. Middle East Respiratory Syndrome (MERS)

    MedlinePlus

    ... United Kingdom (UK), and United States of America (USA). CDC Commentary: Be on the Lookout for MERS- ... OIG 1600 Clifton Road Atlanta , GA 30329-4027 USA 800-CDC-INFO (800-232-4636) , TTY: 888- ...

  2. Traumatic Brain Injury

    MedlinePlus

    ... YouTube Instagram Listen Watch RSS ABOUT About CDC Jobs Funding LEGAL Policies Privacy FOIA No Fear Act OIG 1600 Clifton Road Atlanta , GA 30329-4027 USA 800-CDC-INFO (800-232-4636) , TTY: 888-232-6348 Email ...

  3. 3D electromagnetic modelling of a TTI medium and TTI effects in inversion

    NASA Astrophysics Data System (ADS)

    Jaysaval, Piyoosh; Shantsev, Daniil; de la Kethulle de Ryhove, Sébastien

    2016-04-01

    We present a numerical algorithm for 3D electromagnetic (EM) forward modelling in conducting media with general electric anisotropy. The algorithm is based on the finite-difference discretization of frequency-domain Maxwell's equations on a Lebedev grid, in which all components of the electric field are collocated but half a spatial step staggered with respect to the magnetic field components, which also are collocated. This leads to a system of linear equations that is solved using a stabilized biconjugate gradient method with a multigrid preconditioner. We validate the accuracy of the numerical results for layered and 3D tilted transverse isotropic (TTI) earth models representing typical scenarios used in the marine controlled-source EM method. It is then demonstrated that not taking into account the full anisotropy of the conductivity tensor can lead to misleading inversion results. For simulation data corresponding to a 3D model with a TTI anticlinal structure, a standard vertical transverse isotropic inversion is not able to image a resistor, while for a 3D model with a TTI synclinal structure the inversion produces a false resistive anomaly. If inversion uses the proposed forward solver that can handle TTI anisotropy, it produces resistivity images consistent with the true models.

  4. Saccharomyces cerevisiae Tti2 Regulates PIKK Proteins and Stress Response.

    PubMed

    Hoffman, Kyle S; Duennwald, Martin L; Karagiannis, Jim; Genereaux, Julie; McCarton, Alexander S; Brandl, Christopher J

    2016-01-01

    The TTT complex is composed of the three essential proteins Tel2, Tti1, and Tti2 The complex is required to maintain steady state levels of phosphatidylinositol 3-kinase-related kinase (PIKK) proteins, including mTOR, ATM/Tel1, ATR/Mec1, and TRRAP/Tra1, all of which serve as regulators of critical cell signaling pathways. Due to their association with heat shock proteins, and with newly synthesized PIKK peptides, components of the TTT complex may act as cochaperones. Here, we analyze the consequences of depleting the cellular level of Tti2 in Saccharomyces cerevisiae We show that yeast expressing low levels of Tti2 are viable under optimal growth conditions, but the cells are sensitive to a number of stress conditions that involve PIKK pathways. In agreement with this, depleting Tti2 levels decreased expression of Tra1, Mec1, and Tor1, affected their localization and inhibited the stress responses in which these molecules are involved. Tti2 expression was not increased during heat shock, implying that it does not play a general role in the heat shock response. However, steady state levels of Hsp42 increase when Tti2 is depleted, and tti2L187P has a synthetic interaction with exon 1 of the human Huntingtin gene containing a 103 residue polyQ sequence, suggesting a general role in protein quality control. We also find that overexpressing Hsp90 or its cochaperones is synthetic lethal when Tti2 is depleted, an effect possibly due to imbalanced stoichiometry of a complex required for PIKK assembly. These results indicate that Tti2 does not act as a general chaperone, but may have a specialized function in PIKK folding and/or complex assembly. PMID:27172216

  5. Saccharomyces cerevisiae Tti2 Regulates PIKK Proteins and Stress Response

    PubMed Central

    Hoffman, Kyle S.; Duennwald, Martin L.; Karagiannis, Jim; Genereaux, Julie; McCarton, Alexander S.; Brandl, Christopher J.

    2016-01-01

    The TTT complex is composed of the three essential proteins Tel2, Tti1, and Tti2. The complex is required to maintain steady state levels of phosphatidylinositol 3-kinase-related kinase (PIKK) proteins, including mTOR, ATM/Tel1, ATR/Mec1, and TRRAP/Tra1, all of which serve as regulators of critical cell signaling pathways. Due to their association with heat shock proteins, and with newly synthesized PIKK peptides, components of the TTT complex may act as cochaperones. Here, we analyze the consequences of depleting the cellular level of Tti2 in Saccharomyces cerevisiae. We show that yeast expressing low levels of Tti2 are viable under optimal growth conditions, but the cells are sensitive to a number of stress conditions that involve PIKK pathways. In agreement with this, depleting Tti2 levels decreased expression of Tra1, Mec1, and Tor1, affected their localization and inhibited the stress responses in which these molecules are involved. Tti2 expression was not increased during heat shock, implying that it does not play a general role in the heat shock response. However, steady state levels of Hsp42 increase when Tti2 is depleted, and tti2L187P has a synthetic interaction with exon 1 of the human Huntingtin gene containing a 103 residue polyQ sequence, suggesting a general role in protein quality control. We also find that overexpressing Hsp90 or its cochaperones is synthetic lethal when Tti2 is depleted, an effect possibly due to imbalanced stoichiometry of a complex required for PIKK assembly. These results indicate that Tti2 does not act as a general chaperone, but may have a specialized function in PIKK folding and/or complex assembly. PMID:27172216

  6. 78 FR 15682 - Notification of Proposed Production Activity TTI, Inc.; Subzone 196A (Electromechanical and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-12

    ... Foreign-Trade Zones Board Notification of Proposed Production Activity TTI, Inc.; Subzone 196A (Electromechanical and Circuit Protection Devices Production/ Kitting); Fort Worth, TX TTI, Inc. (TTI), operator of Subzone 196A, submitted a notification of proposed production activity for its facilities located in...

  7. 78 FR 37203 - Authorization of Production Activity; Subzone 196A; TTI, Inc. (Electromechanical and Circuit...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-20

    ... comment (78 FR 15683, 03-12-2013). The FTZ Board has determined that no further review of the activity is... Foreign-Trade Zones Board Authorization of Production Activity; Subzone 196A; TTI, Inc. (Electromechanical and Circuit Protection Devices Production/Kitting); Fort Worth, Texas On February 13, 2013, TTI,...

  8. Calibrations between the variables of microbial TTI response and ground pork qualities.

    PubMed

    Kim, Eunji; Choi, Dong Yeol; Kim, Hyun Chul; Kim, Keehyuk; Lee, Seung Ju

    2013-10-01

    A time-temperature indicator (TTI) based on a lactic acid bacterium, Weissella cibaria CIFP009, was applied to ground pork packaging. Calibration curves between TTI response and pork qualities were obtained from storage tests at 2°C, 10°C, and 13°C. The curves of the TTI vs. total cell number at different temperatures coincided to the greatest extent, indicating the highest representativeness of calibration, by showing the least coefficient of variance (CV=11%) of the quality variables at a given TTI response (titratable acidity) on the curves, followed by pH (23%), volatile basic nitrogen (VBN) (25%), and thiobarbituric acid-reactive substances (TBARS) (47%). Similarity of Arrhenius activation energy (Ea) could also reflect the representativeness of calibration. The total cell number (104.9 kJ/mol) was found to be the most similar to that of the TTI response (106.2 kJ/mol), followed by pH (113.6 kJ/mol), VBN (77.4 kJ/mol), and TBARS (55.0 kJ/mol). PMID:23747630

  9. Alternative stable qP wave equations in TTI media with their applications for reverse time migration

    NASA Astrophysics Data System (ADS)

    Zhou, Yang; Wang, Huazhong; Liu, Wenqing

    2015-10-01

    Numerical instabilities may arise if the spatial variation of symmetry axis is handled improperly when implementing P-wave modeling and reverse time migration in heterogeneous tilted transversely isotropic (TTI) media, especially in the cases where fast changes exist in TTI symmetry axis’ directions. Based on the pseudo-acoustic approximation to anisotropic elastic wave equations in Cartesian coordinates, alternative second order qP (quasi-P) wave equations in TTI media are derived in this paper. Compared with conventional stable qP wave equations, the proposed equations written in stress components contain only spatial derivatives of wavefield variables (stress components) and are free from spatial derivatives involving media parameters. These lead to an easy and efficient implementation for stable P-wave modeling and imaging. Numerical experiments demonstrate the stability and computational efficiency of the presented equations in complex TTI media.

  10. Acceleration of stable TTI P-wave reverse-time migration with GPUs

    NASA Astrophysics Data System (ADS)

    Kim, Youngseo; Cho, Yongchae; Jang, Ugeun; Shin, Changsoo

    2013-03-01

    When a pseudo-acoustic TTI (tilted transversely isotropic) coupled wave equation is used to implement reverse-time migration (RTM), shear wave energy is significantly included in the migration image. Because anisotropy has intrinsic elastic characteristics, coupling P-wave and S-wave modes in the pseudo-acoustic wave equation is inevitable. In RTM with only primary energy or the P-wave mode in seismic data, the S-wave energy is regarded as noise for the migration image. To solve this problem, we derive a pure P-wave equation for TTI media that excludes the S-wave energy. Additionally, we apply the rapid expansion method (REM) based on a Chebyshev expansion and a pseudo-spectral method (PSM) to calculate spatial derivatives in the wave equation. When REM is incorporated with the PSM for the spatial derivatives, wavefields with high numerical accuracy can be obtained without grid dispersion when performing numerical wave modeling. Another problem in the implementation of TTI RTM is that wavefields in an area with high gradients of dip or azimuth angles can be blown up in the progression of the forward and backward algorithms of the RTM. We stabilize the wavefields by applying a spatial-frequency domain high-cut filter when calculating the spatial derivatives using the PSM. In addition, to increase performance speed, the graphic processing unit (GPU) architecture is used instead of traditional CPU architecture. To confirm the degree of acceleration compared to the CPU version on our RTM, we then analyze the performance measurements according to the number of GPUs employed.

  11. Traveltime computation and imaging from rugged topography in 3D TTI media

    NASA Astrophysics Data System (ADS)

    Liu, Shaoyong; Wang, Huazhong; Yang, Qinyong; Fang, Wubao

    2014-02-01

    Foothill areas with rugged topography are of great potential for oil and gas seismic exploration, but subsurface imaging in these areas is very challenging. Seismic acquisition with larger offset and wider azimuth is necessary for seismic imaging in complex areas. However, the scale anisotropy in this case must be taken into account. To generalize the pre-stack depth migration (PSDM) to 3D transversely isotropic media with vertical symmetry axes (VTI) and tilted symmetry axes (TTI) from rugged topography, a new dynamic programming approach for the first-arrival traveltime computation method is proposed. The first-arrival time on every uniform mesh point is calculated based on Fermat's principle with simple calculus techniques and a systematic mapping scheme. In order to calculate the minimum traveltime, a set of nonlinear equations is solved on each mesh point, where the group velocity is determined by the group angle. Based on the new first-arrival time calculation method, the corresponding PSDM and migration velocity analysis workflow for 3D anisotropic media from rugged surface is developed. Numerical tests demonstrate that the proposed traveltime calculation method is effective in both VTI and TTI media. The migration results for 3D field data show that it is necessary to choose a smooth datum to remove the high wavenumber move-out components for PSDM with rugged topography and take anisotropy into account to achieve better images.

  12. Applicability of a microbial Time Temperature Indicator (TTI) for monitoring spoilage of modified atmosphere packed minced meat.

    PubMed

    Vaikousi, Hariklia; Biliaderis, Costas G; Koutsoumanis, Konstantinos P

    2009-08-15

    The applicability of a microbial Time Temperature Indicator (TTI) prototype, based on the growth and metabolic activity of a Lactobacillus sakei strain developed in a previous study, in monitoring quality of modified atmosphere packed (MAP) minced beef was evaluated at conditions simulating the chill chain. At all storage temperatures examined (0, 5, 10, 15 degrees C), the results showed that lactic acid bacteria (LAB) were the dominant bacteria and can be used as a good spoilage index of MAP minced beef. The end of product's shelf life as revealed by the sensory evaluation coincided with a LAB population level of 7 log(10) CFU/g. For all temperatures tested, the growth of L. sakei in the TTI resembled closely the growth of LAB in the meat product, with similar temperature dependence of the micro(max) and thus similar activation energy values calculated as 111.90 and 106.90 kJ/mol, for the two systems, respectively. In addition, the end point of TTI colour change coincided with the time of sensory rejection point of the beef product during its storage under isothermal chilled temperature conditions. The estimated activation energy, E(alpha), values obtained for parameters related to the response of DeltaE (total colour change of the TTI) describing the kinetics of colour change of the TTI during isothermal storage (i.e. the maximum specific rate of DeltaEpsilon evolution curve, micro(DeltaEpsilon), and also the reciprocal of t(i), time at which half of the maximum DeltaEpsilon is reached), were 112.77 and 127.28 kJ/mol, respectively. Finally, the application of the microbial TTI in monitoring the quality deterioration of MAP minced beef due to spoilage was further evaluated under dynamic conditions of storage, using two separate low temperature periodic changing scenarios, resembling the actual conditions occurring in the distribution chill chain. The results showed that the end point of TTI, after storage at those fluctuating temperature conditions, was noted very

  13. German Deaf People Using Text Communication: Short Message Service, TTY, Relay Services, Fax, and E-Mail

    ERIC Educational Resources Information Center

    Power, Des; Power, Mary R.; Rehling, Bernd

    2007-01-01

    An online survey of German deaf people demonstrated that they use text communication through Short Message Service (SMS), e-mail, fax, and telephone typewriters (TTY) to communicate within communities of deaf and hearing people. SMS is used most, with more than 96% of respondents having access to a mobile phone. Most use is intrinsic and directed…

  14. Development of Health Education Learning Module in Bac.TSE-LDPE Programme in TTI: Needs Analysis Study

    ERIC Educational Resources Information Center

    Ujang, Alijah; Alias, Norlidah; Siraj, Saedah

    2015-01-01

    This study is to explore the need to develop learning modules of health education for trainee teachers in the Bachelor Of Teaching (Hons)(Special Education-Learning Disabilities For Primary Education) Programme (Bac.TSE-LDPE) in the Teacher Training Institute (TTI). The questionnaire uses the Likert scale with the close ended questions analysed by…

  15. Optimal rotated staggered-grid finite-difference schemes for elastic wave modeling in TTI media

    NASA Astrophysics Data System (ADS)

    Yang, Lei; Yan, Hongyong; Liu, Hong

    2015-11-01

    The rotated staggered-grid finite-difference (RSFD) is an effective approach for numerical modeling to study the wavefield characteristics in tilted transversely isotropic (TTI) media. But it surfaces from serious numerical dispersion, which directly affects the modeling accuracy. In this paper, we propose two different optimal RSFD schemes based on the sampling approximation (SA) method and the least-squares (LS) method respectively to overcome this problem. We first briefly introduce the RSFD theory, based on which we respectively derive the SA-based RSFD scheme and the LS-based RSFD scheme. Then different forms of analysis are used to compare the SA-based RSFD scheme and the LS-based RSFD scheme with the conventional RSFD scheme, which is based on the Taylor-series expansion (TE) method. The contrast in numerical accuracy analysis verifies the greater accuracy of the two proposed optimal schemes, and indicates that these schemes can effectively widen the wavenumber range with great accuracy compared with the TE-based RSFD scheme. Further comparisons between these two optimal schemes show that at small wavenumbers, the SA-based RSFD scheme performs better, while at large wavenumbers, the LS-based RSFD scheme leads to a smaller error. Finally, the modeling results demonstrate that for the same operator length, the SA-based RSFD scheme and the LS-based RSFD scheme can achieve greater accuracy than the TE-based RSFD scheme, while for the same accuracy, the optimal schemes can adopt shorter difference operators to save computing time.

  16. Seismic Imaging of VTI, HTI and TTI based on Adjoint Methods

    NASA Astrophysics Data System (ADS)

    Rusmanugroho, H.; Tromp, J.

    2014-12-01

    Recent studies show that isotropic seismic imaging based on adjoint method reduces low-frequency artifact caused by diving waves, which commonly occur in two-wave wave-equation migration, such as Reverse Time Migration (RTM). Here, we derive new expressions of sensitivity kernels for Vertical Transverse Isotropy (VTI) using the Thomsen parameters (ɛ, δ, γ) plus the P-, and S-wave speeds (α, β) as well as via the Chen & Tromp (GJI 2005) parameters (A, C, N, L, F). For Horizontal Transverse Isotropy (HTI), these parameters depend on an azimuthal angle φ, where the tilt angle θ is equivalent to 90°, and for Tilted Transverse Isotropy (TTI), these parameters depend on both the azimuth and tilt angles. We calculate sensitivity kernels for each of these two approaches. Individual kernels ("images") are numerically constructed based on the interaction between the regular and adjoint wavefields in smoothed models which are in practice estimated through Full-Waveform Inversion (FWI). The final image is obtained as a result of summing all shots, which are well distributed to sample the target model properly. The impedance kernel, which is a sum of sensitivity kernels of density and the Thomsen or Chen & Tromp parameters, looks crisp and promising for seismic imaging. The other kernels suffer from low-frequency artifacts, similar to traditional seismic imaging conditions. However, all sensitivity kernels are important for estimating the gradient of the misfit function, which, in combination with a standard gradient-based inversion algorithm, is used to minimize the objective function in FWI.

  17. Evidence for tty Production and Measurement of (σ tt)γ/(σtt)

    DOE PAGESBeta

    Aaltonen, T.

    2011-08-31

    Using data corresponding to 6.0 fb-1 of pp collisions at √s = 1.96 TeV collected by the CDF II detector, we present a cross section measurement of top-quark pair production with an additional radiated photon, ttγ. The events are selected by looking for a lepton (ell), a photon (γ), significant transverse momentum imbalance (ET), large total transverse energy, and three or more jets, with at least one identified as containing a b quark (b). The ttγ sample requires the photon to have 10 GeV or more of transverse energy, and to be in the central region. Using an event selectionmore » optimized for the ttγ candidate sample we measure the production cross section of tt (σtt), and the ratio of cross sections of the two samples. Control samples in the dilepton+photon and lepton+photon+ET, channels are constructed to aid in decay product identification and background measurements. We observe 30 ttγ candidate events compared to the standard model expectation of 26.9 ± 3.4 events. We measure the ttγ cross section (σtt) to be 0.18 ± 0.08 pb, and the ratio of σttγ to σtt to be 0.024 ± 0.009. Assuming no tty production, we observe a probability of 0.0015 of the background events alone producing 30 events or more, corresponding to 3.0 standard deviations.« less

  18. Modelling spoilage of fresh turbot and evaluation of a time-temperature integrator (TTI) label under fluctuating temperature.

    PubMed

    Nuin, Maider; Alfaro, Begoña; Cruz, Ziortza; Argarate, Nerea; George, Susie; Le Marc, Yvan; Olley, June; Pin, Carmen

    2008-10-31

    Kinetic models were developed to predict the microbial spoilage and the sensory quality of fresh fish and to evaluate the efficiency of a commercial time-temperature integrator (TTI) label, Fresh Check(R), to monitor shelf life. Farmed turbot (Psetta maxima) samples were packaged in PVC film and stored at 0, 5, 10 and 15 degrees C. Microbial growth and sensory attributes were monitored at regular time intervals. The response of the Fresh Check device was measured at the same temperatures during the storage period. The sensory perception was quantified according to a global sensory indicator obtained by principal component analysis as well as to the Quality Index Method, QIM, as described by Rahman and Olley [Rahman, H.A., Olley, J., 1984. Assessment of sensory techniques for quality assessment of Australian fish. CSIRO Tasmanian Regional Laboratory. Occasional paper n. 8. Available from the Australian Maritime College library. Newnham. Tasmania]. Both methods were found equally valid to monitor the loss of sensory quality. The maximum specific growth rate of spoilage bacteria, the rate of change of the sensory indicators and the rate of change of the colour measurements of the TTI label were modelled as a function of temperature. The temperature had a similar effect on the bacteria, sensory and Fresh Check kinetics. At the time of sensory rejection, the bacterial load was ca. 10(5)-10(6) cfu/g. The end of shelf life indicated by the Fresh Check label was close to the sensory rejection time. The performance of the models was validated under fluctuating temperature conditions by comparing the predicted and measured values for all microbial, sensory and TTI responses. The models have been implemented in a Visual Basic add-in for Excel called "Fish Shelf Life Prediction (FSLP)". This program predicts sensory acceptability and growth of spoilage bacteria in fish and the response of the TTI at constant and fluctuating temperature conditions. The program is freely

  19. Reflection coefficient of qP, qS and SH at a plane boundary between viscoelastic TTI media

    NASA Astrophysics Data System (ADS)

    Wang, Hongwei; Peng, Suping

    2016-01-01

    This paper introduces a calculation method for the effective elastic stiffness tensor matrix of the viscous-elastic TTI medium based on the Chapman theory. We then obtain the phase velocity formula and seismic wave polarization formula of the viscous-elastic TTI medium, by solving the Christoffel equation; solve the phase angle of reflection and transmission wave through the numerical method in accordance with the wave slowness ellipsoid; on the basis of this assumption, and assuming that qP, qS and SH waves occurred simultaneously at the viscous-elastic anisotropic interface, establish the sixth-order Zoeppritz equation in accordance with the boundary conditions; establish the models for the upper and lower media which are viscous-elastic HTI, TTI, etc., on the basis of the sixth-order Zoeppritz equation; and study the impact of fracture dip angle, azimuth angle and frequency on the reflection coefficient. From this we obtain the following conclusions: the reflection coefficient can identify the fracture strike and dip when any information pertaining to the media is unknown; dispersion phenomenon is obvious on the axial plane of symmetry and weakened in the plane vertical to the axial plane of symmetry; the vertical-incidence longitudinal wave can stimulate the qS wave when the dip angle is not 0° or 90° under the condition of coincidence between the symmetry planes of the upper and lower media; when the symmetry planes of the upper and lower media do not coincide and the dip angle is not 0° or 90°, then the vertical-incidence qP will stimulate the qS and SH waves at the same time; the dip angle can cause the reflection coefficient curve to have a more obvious dispersion phenomenon, while the included angle between the symmetry planes of the upper and lower media will weaken the dispersion except SH; and the intercept of reflection coefficient is affected by the fracture dip and included angle between the symmetry planes of the upper and lower media.

  20. 78 FR 2657 - Foreign-Trade Zone 196-Fort Worth, TX, Foreign-Trade Subzone 196A-TTI, Inc.; Application for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-14

    ... Foreign-Trade Zones Board Foreign-Trade Zone 196--Fort Worth, TX, Foreign-Trade Subzone 196A--TTI, Inc.; Application for Additional Subzone Site An application has been submitted to the Foreign-Trade Zones Board... Foreign- Trade Zones Act, as amended (19 U.S.C. 81a-81u), and the regulations of the Board (15 CFR...

  1. 78 FR 14512 - Foreign-Trade Zone 196-Fort Worth, TX, Foreign-Trade Subzone 196A-TTI, Inc., Approval of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-06

    ... Foreign-Trade Zones Board Foreign-Trade Zone 196--Fort Worth, TX, Foreign-Trade Subzone 196A--TTI, Inc... Foreign-Trade Zones (FTZ) Board docketed an application submitted by Alliance Corridor, Inc., grantee of... FR 2657, 1/14/2013). The FTZ staff examiner reviewed the application and determined that it meets...

  2. 49 CFR 571.5 - Matter incorporated by reference

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CFR part 51. For materials subject to change, only the specific version approved by the Director of.... Phone: 1-800-232-4636; Web: http://www.cdc.gov/nchs “Weight, Height, and Selected Body Dimensions of... September 1975, “Motor Vehicle Dimensions” 571.3 Society of Automotive Engineers (SAE) Recommended...

  3. Protect Your Child against Hib Disease

    MedlinePlus

    ... 722 KB] View the Hib Vaccine Information Statement ( English ) or other languages ) Call 1-800-232-4636 (1-800-CDC- ... this? Submit What's this? Submit Button Past Emails Language: English Español (Spanish) File Formats Help: How do I ...

  4. Functionalized S 4Zn (II) complexes as structural modelling for the active site of thiolate-alkylating enzymes: The crystal structure of [TtiZn-SpyH] 2·HClO 4 [Tti = tris(thioimidazolyl)hydroborate and SpyH = pyridine-2-thiol

    NASA Astrophysics Data System (ADS)

    Ibrahim, Mohamed M.

    2009-11-01

    Two new functionalized S 3Zn-bound pyridinethiol complexes [TtiZn-SpyH] 2·HClO 41 and [TtiZn-Spy] 2 [Tti = tris(2-mercapto-1-xylyl-imidazolyl)hydroborate, SpyH = pyridine-2-thiol, and Spy = pyridine-4-thiol] were synthesized and characterized. Structural determination of complex 1 showed that the coordination geometry around zinc atom is ideally regular tetrahedral with three thione donors from the ligand Tti and one thiolate donor from the coligand pyridine-2-thiol. The average Zn(1)-S(thione) bond length is 2.349 Å and the Zn(1)-S(thiolate) bond length is 2.289 Å. The reactivity studies of both complexes 1 and 2 as models for the active sites of thiolate-alkylating enzymes toward methylation reactions showed that 1 is much less susceptible to methylation than that of complex 2. This decrease in the nucleophilicity of complex 1 could be explained by electronic effects of the pyridinum salts as well as the steric hindrance, which is provided by the perchlorate anion.

  5. Tailored and Integrated Web-Based Tools for Improving Psychosocial Outcomes of Cancer Patients: The DoTTI Development Framework

    PubMed Central

    Bryant, Jamie; Sanson-Fisher, Rob; Tzelepis, Flora; Henskens, Frans; Paul, Christine; Stevenson, William

    2014-01-01

    Background Effective communication with cancer patients and their families about their disease, treatment options, and possible outcomes may improve psychosocial outcomes. However, traditional approaches to providing information to patients, including verbal information and written booklets, have a number of shortcomings centered on their limited ability to meet patient preferences and literacy levels. New-generation Web-based technologies offer an innovative and pragmatic solution for overcoming these limitations by providing a platform for interactive information seeking, information sharing, and user-centered tailoring. Objective The primary goal of this paper is to discuss the advantages of comprehensive and iterative Web-based technologies for health information provision and propose a four-phase framework for the development of Web-based information tools. Methods The proposed framework draws on our experience of constructing a Web-based information tool for hematological cancer patients and their families. The framework is based on principles for the development and evaluation of complex interventions and draws on the Agile methodology of software programming that emphasizes collaboration and iteration throughout the development process. Results The DoTTI framework provides a model for a comprehensive and iterative approach to the development of Web-based informational tools for patients. The process involves 4 phases of development: (1) Design and development, (2) Testing early iterations, (3) Testing for effectiveness, and (4) Integration and implementation. At each step, stakeholders (including researchers, clinicians, consumers, and programmers) are engaged in consultations to review progress, provide feedback on versions of the Web-based tool, and based on feedback, determine the appropriate next steps in development. Conclusions This 4-phase framework is evidence-informed and consumer-centered and could be applied widely to develop Web-based programs

  6. Evidence for tty Production and Measurement of (σ tt)γ/(σtt)

    SciTech Connect

    Aaltonen, T.

    2011-08-31

    Using data corresponding to 6.0 fb-1 of pp collisions at √s = 1.96 TeV collected by the CDF II detector, we present a cross section measurement of top-quark pair production with an additional radiated photon, ttγ. The events are selected by looking for a lepton (ell), a photon (γ), significant transverse momentum imbalance (ET), large total transverse energy, and three or more jets, with at least one identified as containing a b quark (b). The ttγ sample requires the photon to have 10 GeV or more of transverse energy, and to be in the central region. Using an event selection optimized for the ttγ candidate sample we measure the production cross section of tt (σtt), and the ratio of cross sections of the two samples. Control samples in the dilepton+photon and lepton+photon+ET, channels are constructed to aid in decay product identification and background measurements. We observe 30 ttγ candidate events compared to the standard model expectation of 26.9 ± 3.4 events. We measure the ttγ cross section (σtt) to be 0.18 ± 0.08 pb, and the ratio of σttγ to σtt to be 0.024 ± 0.009. Assuming no tty production, we observe a probability of 0.0015 of the background events alone producing 30 events or more, corresponding to 3.0 standard deviations.

  7. Ray tracing of multiple transmitted/reflected/converted waves in 2-D/3-D layered anisotropic TTI media and application to crosswell traveltime tomography

    NASA Astrophysics Data System (ADS)

    Bai, Chao-Ying; Huang, Guo-Jiao; Li, Xiao-Ling; Zhou, Bing; Greenhalgh, Stewart

    2013-11-01

    To overcome the deficiency of some current grid-/cell-based ray tracing algorithms, which are only able to handle first arrivals or primary reflections (or conversions) in anisotropic media, we have extended the functionality of the multistage irregular shortest-path method to 2-D/3-D tilted transversely isotropic (TTI) media. The new approach is able to track multiple transmitted/reflected/converted arrivals composed of any kind of combinations of transmissions, reflections and mode conversions. The basic principle is that the seven parameters (five elastic parameters plus two polar angles defining the tilt of the symmetry axis) of the TTI media are sampled at primary nodes, and the group velocity values at secondary nodes are obtained by tri-linear interpolation of the primary nodes across each cell, from which the group velocities of the three wave modes (qP, qSV and qSH) are calculated. Finally, we conduct grid-/cell-based wave front expansion to trace multiple transmitted/reflected/converted arrivals from one region to the next. The results of calculations in uniform anisotropic media indicate that the numerical results agree with the analytical solutions except in directions of SV-wave triplications, at which only the lowest velocity value is selected at the singularity points by the multistage irregular shortest-path anisotropic ray tracing method. This verifies the accuracy of the methodology. Several simulation results show that the new method is able to efficiently and accurately approximate situations involving continuous velocity variations and undulating discontinuities, and that it is suitable for any combination of multiple transmitted/reflected/converted arrival tracking in TTI media of arbitrary strength and tilt. Crosshole synthetic traveltime tomographic tests have been performed, which highlight the importance of using such code when the medium is distinctly anisotropic.

  8. FASTSAT-HSV01 synergistic observations of the magnetospheric response during active periods: MINI-ME, PISA and TTI

    NASA Astrophysics Data System (ADS)

    Casas, Joseph; Collier, Michael; Rowland, Douglas; Sigwarth, John; Boudreaux, Mark

    potentially contribute to space weather research in a synergistic manner. MINI-ME, a neutral atom imager, will observe the neutral atom inputs to ionospheric heating which can be important during high levels of magnetospheric activity. PISA, a plasma impedance spec-trometer, will measure simultaneously the local electron densities and temperatures as well as measure small scale density structure (500 m spatial scale) during these active periods. TTI, a thermospheric imager, will remotely determine the thermospheric temperature response to this magnetospheric activity. Together, these observations will contribute significantly to a comprehensive understanding of the flow of energy through and the response of the storm-time terrestrial magnetosphere.

  9. Hello IM, Goodbye TTY

    ERIC Educational Resources Information Center

    Bell, Lori; Peters, Tom

    2006-01-01

    According to the National Association of the Deaf, there are approximately 28 million deaf and hearing-impaired people in the U.S.--roughly 10 percent of the total population. This hearing-impaired population may be even more isolated than the visually impaired community. Although technology is making it easier for libraries to provide effective…

  10. Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2

    PubMed Central

    Rao, Feng; Cha, Jiyoung; Xu, Jing; Xu, Risheng; Vandiver, M. Scott; Tyagi, Richa; Tokhunts, Robert; Koldobskiy, Michael A.; Fu, Chenglai; Barrow, Roxanne; Wu, Mingxuan; Fiedler, Dorothea; Barrow, James C.; Snyder, Solomon H.

    2014-01-01

    The apoptotic actions of p53 require its phosphorylation by a family of phosphoinositide-3-kinase-related-kinases (PIKKs), which include DNA-PKcs and ATM. These kinases are stabilized by the TTT (Tel2, Tti1, Tti2) co-chaperone family, whose actions are mediated by CK2 phosphorylation. The inositol pyrophosphates, such as 5-diphosphoinositol pentakisphosphate (IP7), are generated by a family of inositol hexakisphosphate kinases (IP6Ks) of which IP6K2 has been implicated in p53-associated cell death. In the present study we report a novel apoptotic signaling cascade linking CK2, TTT, the PIKKs, and p53. We demonstrate that IP7, formed by IP6K2, binds CK2 to enhance its phosphorylation of the TTT complex thereby stabilizing DNA-PKcs and ATM. This process stimulates p53 phosphorylation at serine-15 to activate the cell death program in human cancer cells and in murine B cells. PMID:24657168

  11. FastStats: Birthweight and Gestation

    MedlinePlus

    ... or Physical Activity Obesity and Overweight Smoking Injuries Accidents or Unintentional Injuries All Injuries Assault or Homicide ... Privacy FOIA No Fear Act OIG 1600 Clifton Road Atlanta , GA 30329-4027 USA 800-CDC-INFO ( ...

  12. FastStats: Obstetrical Procedures

    MedlinePlus

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  13. FastStats: Mammography/Breast Cancer

    MedlinePlus

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    MedlinePlus

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    MedlinePlus

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    MedlinePlus

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  17. 75 FR 64735 - Subcommittee for Dose Reconstruction Reviews (SDRR), Advisory Board on Radiation and Worker...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-20

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    MedlinePlus

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    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-25

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    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-23

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  1. Final report for the Tera Computer TTI CRADA

    SciTech Connect

    Davidson, G.S.; Pavlakos, C.; Silva, C.

    1997-01-01

    Tera Computer and Sandia National Laboratories have completed a CRADA, which examined the Tera Multi-Threaded Architecture (MTA) for use with large codes of importance to industry and DOE. The MTA is an innovative architecture that uses parallelism to mask latency between memories and processors. The physical implementation is a parallel computer with high cross-section bandwidth and GaAs processors designed by Tera, which support many small computation threads and fast, lightweight context switches between them. When any thread blocks while waiting for memory accesses to complete, another thread immediately begins execution so that high CPU utilization is maintained. The Tera MTA parallel computer has a single, global address space, which is appealing when porting existing applications to a parallel computer. This ease of porting is further enabled by compiler technology that helps break computations into parallel threads. DOE and Sandia National Laboratories were interested in working with Tera to further develop this computing concept. While Tera Computer would continue the hardware development and compiler research, Sandia National Laboratories would work with Tera to ensure that their compilers worked well with important Sandia codes, most particularly CTH, a shock physics code used for weapon safety computations. In addition to that important code, Sandia National Laboratories would complete research on a robotic path planning code, SANDROS, which is important in manufacturing applications, and would evaluate the MTA performance on this code. Finally, Sandia would work directly with Tera to develop 3D visualization codes, which would be appropriate for use with the MTA. Each of these tasks has been completed to the extent possible, given that Tera has just completed the MTA hardware. All of the CRADA work had to be done on simulators.

  2. T-TY Tank Farm Interim Surface Barrier Demonstration—Vadose Zone Monitoring Plan

    SciTech Connect

    Zhang, Z. F.; Strickland, Christopher E.; Field, Jim G.; Parker, Danny L.

    2010-09-27

    The Hanford Site has 149 underground single-shell tanks that store hazardous radioactive waste. Many of these tanks and their associated infrastructure (e.g., pipelines, diversion boxes) have leaked. Some of the leaked waste has entered the groundwater. The largest known leak occurred from the T-106 Tank of the 241-T Tank Farm in 1973. Five tanks are assumed to have leaked in the TY Farm. Many of the contaminants from those leaks still reside within the vadose zone within the T and TY Tank Farms. The Department of Energy’s Office of River Protection seeks to minimize the movement of these contaminant plumes by placing interim barriers on the ground surface. Such barriers are expected to prevent infiltrating water from reaching the plumes and moving them further. The soil water regime is monitored to determine the effectiveness of the interim surface barriers. Soil-water content and water pressure are monitored using off-the-shelf equipment that can be installed by the hydraulic hammer technique. Four instrument nests were installed in the T Farm in fiscal year (FY) 2006 and FY2007; two nests were installed in the TY Farm in FY2010. Each instrument nest contains a neutron probe access tube, a capacitance probe, and four heat-dissipation units. A meteorological station has been installed at the north side of the fence of the T Farm. This document summarizes the monitoring methods, the instrument calibration and installation, and the vadose zone monitoring plan for interim barriers in T farm and TY Farm.

  3. Convenience of immobilized Bacillus licheniformis alpha-amylase as time-temperature-integrator (TTI).

    PubMed

    De Cordt, S F; Hendrickx, M E; Maesmans, G J; Tobback, P P

    1994-02-01

    For the immobilization of Bacillus licheniformis alpha-amylase to porous glass beads, the performances of three possible linking agents, glutaric dialdehyde, benzoquinone and s-trichlorotriazine were assessed in respect of the protein yield, the enzymic activity and the thermostability of the immobilized enzyme. These three properties are to be evaluated in view of the possible use of the enzyme preparations as time-temperature-integrators (TTIs) for assessing the severity of heat pasteurization or sterilization processes of food or pharmaceuticals. All three linkers improved the enzyme's resistance to irreversible heat inactivation to a similar extent and in each case biphasic inactivation kinetics were observed, whereas the dissolved B. licheniformis alpha-amylase showed a simple first order decay. The immobilization yield, measured as protein per carrier weight, did not differ markedly for the three linkers, although the enzymic activity of the glutaric dialdehyde-linked enzyme was lower than that of the benzoquinone- and s-trichlorotriazine-linked preparations. PMID:7764538

  4. Simultaneous elastic parameter inversion in 2-D/3-D TTI medium combined later arrival times

    NASA Astrophysics Data System (ADS)

    Bai, Chao-ying; Wang, Tao; Yang, Shang-bei; Li, Xing-wang; Huang, Guo-jiao

    2016-04-01

    Traditional traveltime inversion for anisotropic medium is, in general, based on a "weak" assumption in the anisotropic property, which simplifies both the forward part (ray tracing is performed once only) and the inversion part (a linear inversion solver is possible). But for some real applications, a general (both "weak" and "strong") anisotropic medium should be considered. In such cases, one has to develop a ray tracing algorithm to handle with the general (including "strong") anisotropic medium and also to design a non-linear inversion solver for later tomography. Meanwhile, it is constructive to investigate how much the tomographic resolution can be improved by introducing the later arrivals. For this motivation, we incorporated our newly developed ray tracing algorithm (multistage irregular shortest-path method) for general anisotropic media with a non-linear inversion solver (a damped minimum norm, constrained least squares problem with a conjugate gradient approach) to formulate a non-linear inversion solver for anisotropic medium. This anisotropic traveltime inversion procedure is able to combine the later (reflected) arrival times. Both 2-D/3-D synthetic inversion experiments and comparison tests show that (1) the proposed anisotropic traveltime inversion scheme is able to recover the high contrast anomalies and (2) it is possible to improve the tomographic resolution by introducing the later (reflected) arrivals, but not as expected in the isotropic medium, because the different velocity (qP, qSV and qSH) sensitivities (or derivatives) respective to the different elastic parameters are not the same but are also dependent on the inclination angle.

  5. Deaf People Communicating via SMS, TTY, Relay Service, Fax, and Computers in Australia

    ERIC Educational Resources Information Center

    Power, Mary R.; Power, Des; Horstmanshof, Louise

    2007-01-01

    Despite the expansion of Deaf people's use of communication technology little is published about how they use electronic communication in their social and working lives and the implications for their concepts of identity and community. Australia is an ideal research base because the use of a range of technologies is widespread there. To gain…

  6. T-TY Tank Farm Interim Surface Barrier Demonstration - Vadose Zone Monitoring FY10 Report

    SciTech Connect

    Zhang, Z. F.; Strickland, Christopher E.; Field, Jim G.; Parker, Danny L.

    2011-01-01

    The U.S. Department of Energy’s Office of River Protection has constructed interim surface barriers over a portion of the T and TY tank farms as part of the Interim Surface Barrier Demonstration Project. The interim surface barriers (hereafter referred to as the surface barriers or barriers) are designed to minimize the infiltration of precipitation into the soil zones containing radioactive contaminants and minimize the movement of the contaminants. As part of the demonstration effort, vadose zone moisture is being monitored to assess the effectiveness of the barriers at reducing soil moisture. Solar-powered systems were installed to continuously monitor soil water conditions at four locations in the T (i.e., instrument Nests TA, TB, TC, and TD) and the TY (i.e., instrument Nests TYA and TYB) Farms beneath the barriers and outside the barrier footprint as well as site meteorological conditions. Nests TA and TYA are placed in the area outside the barrier footprint and serve as controls, providing subsurface conditions outside the influence of the surface barriers. Nest TB provides subsurface measurements to assess surface-barrier edge effects. Nests TC, TD, and TYB are used to assess changes in soil-moisture conditions beneath the interim surface barriers.

  7. A Study on Social Intelligence in Relation to Scholastic Achievement of Student Teachers of B.Ed. and TTI

    ERIC Educational Resources Information Center

    Brindhamani, M.; Manichander, T.

    2014-01-01

    These are difficult times for educators who believe that learning is worth pursuing for its own sake and that the chief purpose of school is the nurturing of students as whole human beings. Higher test scores seem to be the order of the day. The adventure of learning, the wonder of nature and culture, the richness of human experience, and the…

  8. XUNET experimental high-speed network testbed CRADA 1136, DOE TTI No. 92-MULT-020-B2

    SciTech Connect

    Palmer, R.E.

    1996-04-01

    XUNET is a research program with AT&T and other partners to study high-speed wide area communication between local area networks over a backbone using Asynchronous Transfer Mode (ATM) switches. Important goals of the project are to develop software techniques for network control and management, and applications for high-speed networks. The project entails building a testbed between member sites to explore performance issues for mixed network traffic such as congestion control, multimedia communications protocols, segmentation and reassembly of ATM cells, and overall data throughput rates.

  9. Tissue-type imaging (TTI) based on ultrasonic spectral and clinical parameters for detecting, evaluating, and managing prostate cancer

    NASA Astrophysics Data System (ADS)

    Feleppa, Ernest J.; Ketterling, Jeffrey A.; Dasgupta, Shreedevi; Kalisz, Andrew; Ramachandran, Sarayu; Porter, Christopher R.

    2005-04-01

    This study seeks to develop more-sensitive and -specific ultrasonic methods of imaging cancerous prostate tissue and thereby to improve means of guiding biopsies and planning, targeting, and monitoring treatment. Ultrasonic radio-frequency, echo-signal data, and clinical variables, e.g., PSA, voiding function, etc., during biopsy examinations were acquired. Spectra of the radio-frequency signals were computed in each biopsied region, and used to train neural networks; biopsy results served as the gold standard. A lookup table gave scores for cancer likelihood on a pixel-by-pixel basis from locally computed spectral-parameter and global clinical-parameter values. ROC curves used leave-one-patient- and leave-one-biopsy-out approaches to minimize classification bias. Resulting ROC-curve areas were 0.80+/-0.03 for neural-networks versus 0.66+/-0.03 for conventional classification. TTIs generated from data acquired pre-surgically showed tumors that were unrecognized in conventional images and during surgery. 3-D renderings of prostatectomy histology and TTIs showed encouraging correlations, which shows promise for improving the detection and management of prostate cancer, e.g., for biopsy guidance, planning dose-escalation and tissue-sparing options for radiation or cryotherapy, and assessing the effects of treatment. Combining MRS parameters with US spectral parameters appears capable of further improving prostate-cancer imaging. [Work supported by NIH.

  10. A Critical Examination of the Construct Validity of the TTI Performance DNA[TM] Survey for the Purpose of Differentiating the Entrepreneurially-Minded Engineer

    ERIC Educational Resources Information Center

    Dietrich, Sandra L.

    2012-01-01

    The United States needs workers with more than technical skills to meet the demands of global competition; more specifically, a new breed of engineer is necessary, one who possesses leadership skills and business acumen in addition to the technical engineering skills. One Midwestern foundation has recognized this challenge and is working with…

  11. 78 FR 75368 - 60-Day Notice of Proposed Information Collection: Restrictions on Assistance to Noncitizens

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-11

    ... hearing or speech impairments may access this number through TTY by calling the toll-free Federal Relay...). Persons with hearing or speech impairments may access this number via TTY by calling the...

  12. 78 FR 48709 - 60-Day Notice of Proposed Information Collection: FHA PowerSaver Pilot Program-Title I Property...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-09

    ... available information. Persons with hearing or speech impairments may access this number through TTY by... or speech impairments may access this number through TTY by calling the toll-free Federal...

  13. 77 FR 42323 - Notice of Proposed Information Collection for Public Comment; Screening and Eviction for Drug...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-18

    ... hearing or speech impairments may access this number through TTY by calling the toll-free Federal... number). Persons with hearing or speech impairments may access this number via TTY by calling the...

  14. 47 CFR 6.17 - Informal complaints; form and content.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...., letter, facsimile transmission, telephone (voice/TRS/TTY), Internet e-mail, ASCII text, audio-cassette... transmission, telephone (voice/TRS/TTY), Internet e-mail, ASCII text, audio-cassette recording, braille;...

  15. 47 CFR 6.17 - Informal complaints; form and content.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...., letter, facsimile transmission, telephone (voice/TRS/TTY), Internet e-mail, ASCII text, audio-cassette... transmission, telephone (voice/TRS/TTY), Internet e-mail, ASCII text, audio-cassette recording, braille;...

  16. 47 CFR 6.17 - Informal complaints; form and content.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...., letter, facsimile transmission, telephone (voice/TRS/TTY), Internet e-mail, ASCII text, audio-cassette... transmission, telephone (voice/TRS/TTY), Internet e-mail, ASCII text, audio-cassette recording, braille;...

  17. 47 CFR 79.3 - Video description of video programming.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., such as letter, facsimile transmission, telephone (voice/TRS/TTY), Internet e-mail, audio-cassette... (such as letter, facsimile transmission, telephone (voice/TRS/TTY), Internet e-mail, or some...

  18. 47 CFR 6.17 - Informal complaints; form and content.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...., letter, facsimile transmission, telephone (voice/TRS/TTY), Internet e-mail, ASCII text, audio-cassette... transmission, telephone (voice/TRS/TTY), Internet e-mail, ASCII text, audio-cassette recording, braille;...

  19. 47 CFR 6.17 - Informal complaints; form and content.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...., letter, facsimile transmission, telephone (voice/TRS/TTY), Internet e-mail, ASCII text, audio-cassette... transmission, telephone (voice/TRS/TTY), Internet e-mail, ASCII text, audio-cassette recording, braille;...

  20. 77 FR 18814 - Emergency Access Advisory Committee; Announcement of Date of Next Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    ...; Detailed Report Sections from 2011; NENA i3 compared to EAAC Recommendations; TTY Transition/Roadmap; and... compared to EAAC Recommendations; TTY Transition/Roadmap; Timeline Alignment For Phasing into NG911...

  1. 47 CFR 79.3 - Video description of video programming.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., such as letter, facsimile transmission, telephone (voice/TRS/TTY), Internet e-mail, audio-cassette... (such as letter, facsimile transmission, telephone (voice/TRS/TTY), Internet e-mail, or some other... Commission by any reasonable means, such as letter, facsimile transmission, telephone (voice/TRS/TTY),...

  2. Continuous measurement of tympanic temperature with a new infrared method using an optical fiber.

    PubMed

    Shibasaki, M; Kondo, N; Tominaga, H; Aoki, K; Hasegawa, E; Idota, Y; Moriwaki, T

    1998-09-01

    The purpose of this study was to investigate the utility of an infrared tympanic thermometry by using an optical fiber for measuring tympanic temperature (Tty). In the head cooling and facial fanning tests during normothermia, right Tty measured by this method (infrared-Tty) and esophageal temperature (Tes) were not affected by decreased temple and forehead skin temperatures, suggesting that the infrared sensor in this system measured the infrared radiation from the tympanic membrane selectively. Eight male subjects took part in passive-heat-stress and progressive-exercise tests. No significant differences among infrared-Tty, the left Tty measured by thermistor (contact-Tty), and Tes were observed at rest or at the end of each experiment, and there was no significant difference in the increase in these core temperatures from rest to the end. Furthermore, there were no significant differences in the core temperature threshold at the onset of sweating and slope (the relationship of sweating rate vs. infrared-Tty and vs. contact-Tty). These results suggest that this method makes it possible to measure Tty accurately, continuously, and more safely. PMID:9729565

  3. What Is Spinal Stenosis?

    MedlinePlus

    ... 22–NIAMS TTY: 301–565–2966 Fax: 301–718–6366 Email: NIAMSinfo@mail.nih.gov Website: www. ... 226–4267) TTY: 301–565–2966 Fax: 301–718–6366 Email: NIAMSinfo@mail.nih.gov Website: www. ...

  4. Carpal Tunnel Syndrome

    MedlinePlus

    ... 226-4267 Toll-Free; (301) 565-2966 TTY Internet Address: http://www.niams.nih.gov/ National Institute ... 352-9424 Toll-Free; (301) 468-5981 TTY Internet Address: http://www.ninds.nih.gov/ National Institute ...

  5. WWC Review of the Report "Transfer Incentives for High-Performing Teachers: Final Results from a Multisite Randomized Experiment." What Works Clearinghouse Single Study Review

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2015

    2015-01-01

    For the 2013 study, "Transfer Incentives for High-Performing Teachers: Final Results from a Multisite Randomized Experiment," researchers examined the impact of the Talent Transfer Initiative (TTI) on students' reading and mathematics achievement in 10 school districts. The TTI enabled principals of low-performing schools to provide…

  6. Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes

    SciTech Connect

    Takai, Hiroyuki; Xie, Yihu; de Lange, Titia; Pavletich, Nikola P.

    2010-09-20

    We reported previously that the stability of all mammalian phosphatidylinositol 3-kinase-related protein kinases (PIKKs) depends on their interaction with Tel2, the ortholog of yeast Tel2 and Caenorhabditis elegans Clk-2. Here we provide evidence that Tel2 acts with Hsp90 in the maturation of PIKK complexes. Quantitative immunoblotting showed that the abundance of Tel2 is low compared with the PIKKs, and Tel2 preferentially bound newly synthesized ATM, ATR, mTOR, and DNA-PKcs. Tel2 complexes contained, in addition to Tti1-Tti2, the Hsp90 chaperone, and inhibition of Hsp90 interfered with the interaction of Tel2 with the PIKKs. Analysis of in vivo labeled nascent protein complexes showed that Tel2 and Hsp90 mediate the formation of the mTOR TORC1 and TORC2 complexes and the association of ATR with ATRIP. The structure of yeast Tel2, reported here, shows that Tel2 consists of HEAT-like helical repeats that assemble into two separate {alpha}-solenoids. Through mutagenesis, we identify a surface patch of conserved residues involved in binding to the Tti1-Tti2 complex in vitro. In vivo, mutation of this conserved patch affects cell growth, levels of PIKKs, and ATM/ATR-mediated checkpoint signaling, highlighting the importance of Tti1-Tti2 binding to the function of Tel2. Taken together, our data suggest that the Tel2-Tti1-Tti2 complex is a PIKK-specific cochaperone for Hsp90.

  7. Empirical relation between carbonate porosity and thermal maturity: an approach to regional porosity prediction.

    USGS Publications Warehouse

    Schmoker, J.W.

    1984-01-01

    Carbonate porosity can be predicted approximately on a regional scale as a function of thermal maturity. Thus: theta = a (TTI) b, where theta = regional porosity, a = a constant for a given region and varies by an order of magnitude, TTI = Lopatin's time-T index of thermal maturity and b approx -0.372. -K.A.R.

  8. 75 FR 66054 - Nondiscrimination on the Basis of Disability in State and Local Government Services, Public...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-27

    ... Line at (800) 514-0301 (Voice) or (800) 514-0383 (TTY), 9:30 a.m. to 5:30 p.m. Monday, Tuesday... Information Line at (800) 514-0301 (Voice) or (800) 514-0383 (TTY) at least five business days in advance of... other accommodations, auxiliary aids, or foreign language translation should contact Linda Garrett...

  9. 77 FR 41404 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-13

    ... Commission sessions.) Please telephone (202) 663-7100 (voice) and (202) 663-4074 (TTY) at any time for... Realtime Translation (CART) services at Commission meetings for the hearing impaired. Requests for other reasonable accommodations may be made by using the voice and TTY numbers listed above. CONTACT PERSON...

  10. 76 FR 31611 - Sunshine Act Meeting Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-01

    ... Commission sessions.) Please telephone (202) 663-7100 (voice) and (202) 663-4074 (TTY) at any time for... Realtime Translation (CART) services at Commission meetings for the hearing impaired. Requests for other reasonable accommodations may be made by using the voice and TTY numbers listed above. CONTACT PERSON...

  11. 76 FR 12733 - Sunshine Act Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-08

    ....) Please telephone (202) 663-7100 (voice) and (202) 663-4074 (TTY) at any time for information on these meetings. The EEOC provides sign language interpretation and Communication Access Realtime Translation... other reasonable accommodations may be made by using the voice and TTY numbers listed above....

  12. 78 FR 67144 - Sunshine Act Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-08

    ... Commission sessions.) Please telephone (202) 663-7100 (voice) and (202) 663-4074 (TTY) at any time for... Realtime Translation (CART) services at Commission meetings for the hearing impaired. Requests for other reasonable accommodations may be made by using the voice and TTY numbers listed above. CONTACT PERSON...

  13. 77 FR 13070 - National Advisory Committee on Microbiological Criteria for Foods

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-05

    ... above. Persons requiring special accommodations for this phone conference (voice and TTY) should notify... formats. In some cases, document conversion may result in character translation or formatting errors. The... contact USDA's Target Center at (202) 720-2600 (voice and TTY). To file a written complaint...

  14. 76 FR 34985 - Sunshine Act; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-15

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  15. 75 FR 51812 - The Consumer and Governmental Affairs Bureau Seeks Comment on the Commission's Policies and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-23

    ..., Consumer Affairs and Outreach Division, at (202) 418- 2498 (voice), (202) 418-1169 (TTY), or e-mail at Pam... (voice) or (202) 418-0432 (tty). Synopsis In document DA 10-1325, the Bureau initiates a review of the..., Braille documents, assistive listening devices, Communication Access Realtime Translation...

  16. 77 FR 24201 - Sunshine Act Meeting Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-23

    ... advance on future Commission sessions.) Please telephone (202) 663-7100 (voice) and (202) 663-4074 (TTY... Communication Access Realtime Translation (CART) services at Commission meetings for the hearing impaired. Requests for other reasonable accommodations may be made by using the voice and TTY numbers listed...

  17. 78 FR 11179 - Sunshine Act Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-15

    ... sessions.) Please telephone (202) 663-7100 (voice) and (202) 663-4074 (TTY) at any time for information on... Translation (CART) services at Commission meetings for the hearing impaired. Requests for other reasonable accommodations may be made by using the voice and TTY numbers listed above. CONTACT PERSON FOR MORE...

  18. 76 FR 42709 - Sunshine Act Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-19

    ... Commission sessions.) Please telephone (202) 663-7100 (voice) and (202) 663-4074 (TTY) at any time for... Realtime Translation (CART) services at Commission meetings for the hearing impaired. Requests for other reasonable accommodations may be made by using the voice and TTY numbers listed above. CONTACT PERSON...

  19. 76 FR 56143 - National Advisory Committee on Microbiological Criteria for Foods

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-12

    ... variety of source formats. In some cases, document conversion may result in character translation or... contact USDA's Target Center at (202) 720-2600 (voice and TTY). To file a written complaint of...., Washington, DC 20250-9410 or call (202) 720-5964 (voice and TTY). USDA is an equal opportunity provider...

  20. 78 FR 26031 - Sunshine Act Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-03

    ... Commission sessions.) Please telephone (202) 663-7100 (voice) and (202) 663-4074 (TTY) at any time for... Realtime Translation (CART) services at Commission meetings for the hearing impaired. Requests for other reasonable accommodations may be made by using the voice and TTY numbers listed above. CONTACT PERSON...

  1. Hoarseness

    MedlinePlus

    ... MD 20892-3456 Toll-free Voice: (800) 241-1044 Toll-free TTY: (800) 241-1055 Email: nidcdinfo@ ... questions in English or Spanish. Voice: (800) 241-1044 TTY: (800) 241-1055 nidcdinfo@nidcd.nih.gov ...

  2. 36 CFR 1193.3 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., but are not limited to, voice, fax, relay service, TTY, Internet posting, captioning, text-to-speech.... Alternate formats may include, but are not limited to, Braille, ASCII text, large print, and audio cassette.... TTY. An abbreviation for teletypewriter. Machinery or equipment that employs interactive text...

  3. 36 CFR 1193.3 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., but are not limited to, voice, fax, relay service, TTY, Internet posting, captioning, text-to-speech.... Alternate formats may include, but are not limited to, Braille, ASCII text, large print, and audio cassette.... TTY. An abbreviation for teletypewriter. Machinery or equipment that employs interactive text...

  4. 75 FR 58422 - Notice of Voluntary Request To Indicate Intent To Apply for the Fiscal Year (FY) 2010 Choice...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-24

    ... Grants. Persons with hearing or speech impairments may access these numbers via TTY by calling the... is not a toll-free number). Persons with hearing or speech impairments may access these telephone numbers through a text ] telephone (TTY) by calling the toll-free Federal Information Relay Service at...

  5. [Comparative study of 2 methods of measuring intestinal transit time].

    PubMed

    Vidal-Neira, L; León-Barúa, R

    1981-01-01

    In 20 healthy volunteers, intestinal transit times, obtained following a simple method, recently described, in which a small liquid-containing rubber bag is used as a marker, were compared with the times obtained following, simultaneously, another method, already universally accepted, in which small barium-impregnated pellets are used as markers. The intestinal transit determined with the rubber bag (TTI-B) (14.1 - 79.2 hours; mean +/- s.d.: 42.4 +/- 20.7 hours) were significantly shorter than the times determined with the plastic pellets (TTI) (26.4 - 88.1 hours; mean +/- s.d.: 60.2 +/- 25.5 hours (P less than 0.001). But, TTI-B and TTI correlate closely (r: + 0.86), and, furthermore, TTI-B results may be converted to TTI results with the help of a simple regression equation: TTI (in minutes) = 831 + 1.09 TTI-B (in minutes). After analyzing what has been observed in the present work and in previous works, it was concluded that the new method to measure intestinal transient time using the small rubber bag is reliable and simple, and that it may help to better understand what happens in some important gastrointestinal problems. PMID:7342626

  6. Tris(thioimidazolyl)borate-zinc-thiolate complexes for the modeling of biological thiolate alkylations.

    PubMed

    Ibrahim, Mohamed M; Seebacher, Jan; Steinfeld, Gunther; Vahrenkamp, Heinrich

    2005-11-14

    The S3Zn-SR coordination of thiolate-alkylating enzymes such as the Ada DNA repair protein was reproduced in tris(thioimidazolyl)borate-zinc-thiolate complexes Tti(R)Zn-SR'. Four different Tti(R) ligands and nine different thiolates were employed, yielding a total of 12 new complexes. In addition, one Tti(R)Zn-SH complex and two thiolate-bridged [Tti(R)-SEt-Tti(R)]+ complexes were obtained. A selection of six thiolate complexes was converted with methyl iodide to the corresponding methyl thioethers and Tti(R)Zn-I. According to a kinetic analysis these reactions are second-order processes, which implies that the alkylations are likely to occur at the zinc-bound thiolates. They are much faster than the alkylations of zinc thiolates with N3 or N2S tripod ligands. The most reactive thiolate, Tti(Xyl)Zn-SEt, reacts slowly with trimethyl phosphate in a nonpolar medium at room temperature, yielding methyl-ethyl-thioether and Tti(Xyl)Zn-OPO(OMe)2 which can be converted back to the thiolate complex with NaSEt. This is the closest reproduction of the Ada repair process so far. PMID:16270993

  7. Survival Impact of Increasing Time to Treatment Initiation for Patients With Head and Neck Cancer in the United States

    PubMed Central

    Murphy, Colin T.; Handorf, Elizabeth A.; Egleston, Brian L.; Wang, Lora S.; Mehra, Ranee; Flieder, Douglas B.; Ridge, John A.

    2016-01-01

    Purpose To estimate the overall survival (OS) impact from increasing time to treatment initiation (TTI) for patients with head and neck squamous cell carcinoma (HNSCC). Methods Using the National Cancer Data Base (NCDB), we examined patients who received curative therapy for the following sites: oral tongue, oropharynx, larynx, and hypopharynx. TTI was the number of days from diagnosis to initiation of curative treatment. The effect of TTI on OS was determined by using Cox regression models (MVA). Recursive partitioning analysis (RPA) identified TTI thresholds via conditional inference trees to estimate the greatest differences in OS on the basis of randomly selected training and validation sets, and repeated this 1,000 times to ensure robustness of TTI thresholds. Results A total of 51,655 patients were included. On MVA, TTI of 61 to 90 days versus less than 30 days (hazard ratio [HR], 1.13; 95% CI, 1.08 to 1.19) independently increased mortality risk. TTI of 67 days appeared as the optimal threshold on the training RPA, statistical significance was confirmed in the validation set (P < .001), and the 67-day TTI was the optimal threshold in 54% of repeated simulations. Overall, 96% of simulations validated two optimal TTI thresholds, with ranges of 46 to 52 days and 62 to 67 days. The median OS for TTI of 46 to 52 days or fewer versus 53 to 67 days versus greater than 67 days was 71.9 months (95% CI, 70.3 to 73.5 months) versus 61 months (95% CI, 57 to 66.1 months) versus 46.6 months (95% CI, 42.8 to 50.7 months), respectively (P < .001). In the most recent year with available data (2011), 25% of patients had TTI of greater than 46 days. Conclusion TTI independently affects survival. One in four patients experienced treatment delay. TTI of greater than 46 to 52 days introduced an increased risk of death that was most consistently detrimental beyond 60 days. Prolonged TTI is currently affecting survival. PMID:26628469

  8. Pervasive Developmental Disorders

    MedlinePlus

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  9. Research Areas: Liver Disease

    MedlinePlus

    ... NIDDK-funded research is investigating the role gut microbes may play in the progression of nonalcoholic fatty ... 2560, Telephone: 301-496-3583 Contact the NIDDK Health Information Center Phone: 1-800-860-8747 | TTY: ...

  10. 78 FR 7764 - Information Collection; Submission for OMB Review, Comment Request

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    ... email to cclay@cns.gov . Individuals who use a telecommunications device for the deaf (TTY-TDD) may call... for the Corporation for National and Community Service; and (2) Electronically by email to:...

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    2012-04-20

    ... email to zjackson@cns.gov . Individuals who use a telecommunications device for the deaf (TTY-TDD) may... for the Corporation for National and Community Service; and (2) Electronically by email to:...

  12. 77 FR 7597 - Waiver of Debt

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    2012-02-13

    ... speech disability or hearing loss and use a TTY, call 1-800-462-7585 directly; if you use 711 or Video... Register (76 FR 14039) that announced FEMA's recoupment process for collecting overpayments (debts) made...

  13. 77 FR 61032 - Notice of Sunshine Act Meetings; Correction

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    2012-10-05

    ..., DC 20004; 202-272-2004 (V), 202-272-2074 (TTY). In the Federal Register of October 3, 2012, in FR Doc... personal care products such as perfumes, hairsprays, colognes, and deodorants. Dated: October 3,...

  14. 36 CFR 1193.51 - Compatibility.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... a connector by the user. (b) Connection point for external audio processing devices. Products providing auditory output shall provide the auditory signal at a standard signal level through an industry...) TTY signal compatibility. Products, including those providing voice communication functionality,...

  15. Development of Aa New Time Temperature Indicator for Enzymatic Validation of Pasteurization of Meat Products.

    PubMed

    Brizio, Ana Paula Dutra Resem; Prentice, Carlos

    2015-06-01

    This paper presents the development of a new smart time-temperature indicator (TTI) of pasteurization whose operating principle is based on the complexation reaction between starch and iodine, and the subsequent action of an amylase on this complex causing its discoloration at a rate dependent on time and temperature of the medium. Laboratory simulations and tests in a manufacturing plant evaluated different enzyme concentrations in the TTI prototypes when exposed to pasteurization conditions. The results showed that the color response of the indicators was visually interpreted as adaptive to measurement using appropriate equipment, with satisfactory reliability in all conditions studied. The TTI containing 6.5% amylase was one whose best results were suited for use in validating the cooking of hams. When attached to the primary packaging of the product, this TTI indicated the pasteurization process inexpensively, easily, accurately, and nondestructively. PMID:25944498

  16. 78 FR 75368 - 60-Day Notice of Proposed Information Collection: HUD Multifamily Energy Assessment

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    ...@hud.gov . Persons with hearing or speech impairments may access this number through TTY by calling the..., (this is not a toll- free number). Persons with hearing or speech impairments may access this number...

  18. 78 FR 45945 - 60-Day Notice of Proposed Information Collection: Contractor's Requisition-Project Mortgages

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    2013-07-30

    ... proposed forms or other available information. Persons with hearing or speech impairments may access this... speech impairments may access this number through TTY by calling the toll-free Federal Relay Service...

  19. 78 FR 25071 - Combined Notice of Filings #2

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    ..., NedPower Mt. Storm, LLC, Kincaid Generation, LLC, Fowler Rider Wind Farm, LLC. Description: Quarterly... information, call (866) 208-3676 (toll free). For TTY, call (202) 502-8659. Dated: April 18, 2013. Nathaniel...

  20. 78 FR 77444 - Natural Gas Pipeline Company of America LLC; Stingray Pipeline Company, L.L.C.; Notice of...

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    ... TTY, (202) 502-8659. Any questions regarding the applications should be directed Bruce H. Newsome..., Illinois 60515-7918, telephone: 630-725-3070, or email: bruce_newsome@kindermorgan.com or to Cynthia...

  1. 78 FR 64442 - Petition for Reconsideration of Action in Rulemaking Proceeding

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-29

    ... the 2000- 2020 MHz and 2180-2200 MHz Bands, published at 78 FR 8229 February 5, 2013, in WT Docket Nos... INFORMATION CONTACT: Matthew Pearl, Wireless Telecommunications Bureau, phone: (202) 418-2607 or TTY (202)...

  2. Finite Difference Modeling of Wave Progpagation in Acoustic TiltedTI Media

    SciTech Connect

    Zhang, Linbin; Rector III, James W.; Hoversten, G. Michael

    2005-03-21

    Based on an acoustic assumption (shear wave velocity is zero) and a dispersion relation, we derive an acoustic wave equation for P-waves in tilted transversely isotropic (TTI) media (transversely isotropic media with a tilted symmetry axis). This equation has fewer parameters than an elastic wave equation in TTI media and yields an accurate description of P-wave traveltimes and spreading-related attenuation. Our TTI acoustic wave equation is a fourth-order equation in time and space. We demonstrate that the acoustic approximation allows the presence of shear waves in the solution. The substantial differences in traveltime and amplitude between data created using VTI and TTI assumptions is illustrated in examples.

  3. Computer Workstations: Wrist/Palm Supports

    MedlinePlus

    ... OF LABOR Occupational Safety and Health Administration 200 Constitution Ave., NW, Washington, DC 20210 800-321-6742 (OSHA) TTY www.OSHA.gov FEDERAL GOVERNMENT White House Affordable Care Act Disaster Recovery ...

  4. Computer Workstations: Keyboards

    MedlinePlus

    ... OF LABOR Occupational Safety and Health Administration 200 Constitution Ave., NW, Washington, DC 20210 800-321-6742 (OSHA) TTY www.OSHA.gov FEDERAL GOVERNMENT White House Affordable Care Act Disaster Recovery ...

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  7. Safety and Health Topics: Asbestos

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    ... OF LABOR Occupational Safety and Health Administration 200 Constitution Ave., NW, Washington, DC 20210 800-321-6742 (OSHA) TTY www.OSHA.gov FEDERAL GOVERNMENT White House Affordable Care Act Disaster Recovery ...

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    ... OF LABOR Occupational Safety and Health Administration 200 Constitution Ave., NW, Washington, DC 20210 800-321-6742 (OSHA) TTY www.OSHA.gov FEDERAL GOVERNMENT White House Affordable Care Act Disaster Recovery ...

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  14. Computer Workstations: Good Working Positions

    MedlinePlus

    ... OF LABOR Occupational Safety and Health Administration 200 Constitution Ave., NW, Washington, DC 20210 800-321-6742 (OSHA) TTY www.OSHA.gov FEDERAL GOVERNMENT White House Affordable Care Act Disaster Recovery ...

  15. Selecting PPE for the Workplace (Personal Protective Equipment for the Eyes and Face)

    MedlinePlus

    ... OF LABOR Occupational Safety and Health Administration 200 Constitution Ave., NW, Washington, DC 20210 800-321-6742 (OSHA) TTY www.OSHA.gov FEDERAL GOVERNMENT White House Affordable Care Act Disaster Recovery ...

  16. Digestive Diseases A-Z

    MedlinePlus

    ... Anatomic Problems of the Lower GI Tract Iron Overload Disease Hemochromatosis Irritable Bowel Syndrome Irritable bowel syndrome ( ... Telephone: 301-496-3583 Contact the NIDDK Health Information Center Phone: 1-800-860-8747 | TTY: 1- ...

  17. 47 CFR 7.17 - Informal complaints; form and content.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., telephone (voice/TRS/TTY), Internet e-mail, ASCII text, Internet e-mail, audio-cassette recording, and... complaint by the Commission and defendant (e.g., letter, facsimile transmission, telephone...

  18. 47 CFR 68.417 - Informal complaints; form and content.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... reasonable means, e.g., letter, facsimile transmission, telephone (voice/TRS/TTY), Internet e-mail, ASCII... complaint by the Commission and defendant (e.g., letter, facsimile transmission, telephone...

  19. 47 CFR 7.17 - Informal complaints; form and content.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., telephone (voice/TRS/TTY), Internet e-mail, ASCII text, Internet e-mail, audio-cassette recording, and... complaint by the Commission and defendant (e.g., letter, facsimile transmission, telephone...

  20. 47 CFR 68.417 - Informal complaints; form and content.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... reasonable means, e.g., letter, facsimile transmission, telephone (voice/TRS/TTY), Internet e-mail, ASCII... complaint by the Commission and defendant (e.g., letter, facsimile transmission, telephone...

  1. 47 CFR 7.17 - Informal complaints; form and content.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., telephone (voice/TRS/TTY), Internet e-mail, ASCII text, Internet e-mail, audio-cassette recording, and... complaint by the Commission and defendant (e.g., letter, facsimile transmission, telephone...

  2. 47 CFR 7.17 - Informal complaints; form and content.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., telephone (voice/TRS/TTY), Internet e-mail, ASCII text, Internet e-mail, audio-cassette recording, and... complaint by the Commission and defendant (e.g., letter, facsimile transmission, telephone...

  3. 47 CFR 68.417 - Informal complaints; form and content.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... reasonable means, e.g., letter, facsimile transmission, telephone (voice/TRS/TTY), Internet e-mail, ASCII... complaint by the Commission and defendant (e.g., letter, facsimile transmission, telephone...

  4. 47 CFR 7.17 - Informal complaints; form and content.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., telephone (voice/TRS/TTY), Internet e-mail, ASCII text, Internet e-mail, audio-cassette recording, and... complaint by the Commission and defendant (e.g., letter, facsimile transmission, telephone...

  5. 47 CFR 68.417 - Informal complaints; form and content.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... reasonable means, e.g., letter, facsimile transmission, telephone (voice/TRS/TTY), Internet e-mail, ASCII... complaint by the Commission and defendant (e.g., letter, facsimile transmission, telephone...

  6. 47 CFR 68.417 - Informal complaints; form and content.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... reasonable means, e.g., letter, facsimile transmission, telephone (voice/TRS/TTY), Internet e-mail, ASCII... complaint by the Commission and defendant (e.g., letter, facsimile transmission, telephone...

  7. 36 CFR 1194.23 - Telecommunications products.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Telecommunications products. (a) Telecommunications products or systems which provide a function allowing voice... intermix speech with TTY use. (b) Telecommunications products which include voice communication.... (c) Voice mail, auto-attendant, and interactive voice response telecommunications systems shall...

  8. 36 CFR 1194.23 - Telecommunications products.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Telecommunications products. (a) Telecommunications products or systems which provide a function allowing voice... intermix speech with TTY use. (b) Telecommunications products which include voice communication.... (c) Voice mail, auto-attendant, and interactive voice response telecommunications systems shall...

  9. 76 FR 41236 - FPL Energy Maine Hydro, LLC; Notice of Application Accepted for Filing and Soliciting Comments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-13

    ... reproduction at the Commission's Public Reference Room, located at 888 First Street, NE., Room 2A, Washington...@ferc.gov , for TTY, call (202) 502-8659. A copy is also available for inspection and reproduction...

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    2013-10-16

    ...- Atlantic Hydro, LLC, 5425 Wisconsin Avenue, Ste. 600, Chevy Chase, MD 20815; phone (301) 718-4432 or (301... (toll free), or (202) 502- 8659 (TTY). In lieu of electronic filing, please send a paper copy...

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    ...: Kristina Johnson, Mid-Atlantic Hydro, LLC, 5425 Wisconsin Avenue, Suite 600, Chevy Chase, MD 20815; phone...) 502-8659 (TTY). In lieu of electronic filing, please send a paper copy to: Secretary, Federal...

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    ... reproduction at the Commission's Public Reference Room, located at 888 First Street NE., Room 2A, Washington... , for TTY, call (202) 502-8659. A copy is also available for inspection and reproduction at the...

  13. 76 FR 9348 - Southern California Edison Company, Pacific Gas and Electric Company, San Diego Gas & Electric...

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    2011-02-17

    ... Purchase of Excess Electricity Under Assembly Bill 1613, D.09-12-042 (Dec. 21, 2009), (2) Order Dismissing... free). For TTY, call (202) 502-8659. Comment Date: 5 p.m. Eastern Time on February 22, 2011....

  14. 78 FR 43193 - Combined Notice of Filings #1

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    2013-07-19

    ... Corporation, et al. submits an updated market power screen analysis for wholesale electricity markets in the... other information, call (866) 208-3676 (toll free). For TTY, call (202) 502-8659. Dated: July 11,...

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    2011-11-04

    ...: 20111028-5042. Comment Date: 5 p.m. Eastern Time on Wednesday, November 09, 2011. Docket Numbers: RP12-71...). For TTY, call (202) 502- 8659. Dated: October 31, 2011. Nathaniel J. Davis, Sr., Deputy...

  17. 36 CFR 1193.51 - Compatibility.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... a connector by the user. (b) Connection point for external audio processing devices. Products providing auditory output shall provide the auditory signal at a standard signal level through an industry...) TTY signal compatibility. Products, including those providing voice communication functionality,...

  18. 36 CFR 1193.51 - Compatibility.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... a connector by the user. (b) Connection point for external audio processing devices. Products providing auditory output shall provide the auditory signal at a standard signal level through an industry...) TTY signal compatibility. Products, including those providing voice communication functionality,...

  19. 77 FR 11526 - Ken Willis; Notice of Availability of Environmental Assessment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-27

    ... regulations, 18 CFR part 380 (Order No. 486, 52 FR 47897), the Office of Energy Projects has reviewed the... TTY, (202) 502-8659. Please contact Matt Buhyoff by telephone at (202) 502-6824 or by email at...

  20. Transfusion transmitted infections – A retrospective analysis from the National Blood Transfusion Service in Eritrea

    PubMed Central

    Fessehaye, Nahom; Naik, Durgadas; Fessehaye, Tesfay

    2011-01-01

    Background The emergence of transfusion transmitted infection (TTI) especially HIV/AIDS has created a huge obstacle in ensuring blood safety. To assess the situation in Eritrea, we carried out a retrospective study of 29,501 blood donors for the prevalence of TTI's i.e. HIV, HBV, HCV and Syphilis. Methods The study population included all donors who donated blood from January 2006 to November 2009. The data was collected from the National Blood Transfusion Services (NTBS) of Eritrea and includes category of donor and result for TTI markers. Results A total of 29,501 units of blood were collected from 23,385(79%) voluntary blood donors and the rest 6,116(21%) units were collected from family replacement donors. The over all prevalence of TTI's were 3.8% with 3.5% in voluntary blood donors and 5.1% in family replacement donors. The sero-prevalence for TTI markers were 0.18% HIV, 2.58% HBV, 0.57% HCV and 0.49% Syphilis. Conclusion In conclusion, even if the TTI prevalence rate among Eritrean blood donors is low, ensuring blood safety has a long way to go. PMID:22145069

  1. Development of a Microbial Time/Temperature Indicator Prototype for Monitoring the Microbiological Quality of Chilled Foods▿

    PubMed Central

    Vaikousi, Hariklia; Biliaderis, Costas G.; Koutsoumanis, Konstantinos P.

    2008-01-01

    A time/temperature indicator (TTI) system based on the growth and metabolic activity of a Lactobacillus sakei strain was developed for monitoring food quality throughout the chilled-food chain. In the designed system, an irreversible color change of a chemical chromatic indicator (from red to yellow) progressively occurs due to the pH decline that results from microbial growth and metabolism in a selected medium. The relation of the TTI response (color change) to the growth and metabolic activity (glucose consumption, lactic acid production, pH decrease) of L. sakei was studied. In addition, the temperature dependence of the TTI kinetics was investigated isothermally in the range of 0 to 16°C and modeled with a system of differential equations. At all temperatures tested, the pH and color changes of the TTI system followed closely the growth of L. sakei, with the endpoint (the time at which a distinct visual color change to the final yellow was observed) of the TTI coinciding with a population level of 107 to 108 CFU/ml. The endpoint decreased from 27 days at 0°C to 2.5 days at 16°C, yielding an activation energy of 97.7 kJ/mol, which was very close to the activation energy of the L. sakei growth rate in the TTI substrate (103.2 kJ/mol). Furthermore, experiments conducted on the effect of the inoculum level showed a negative linear relationship between the level of L. sakei inoculated in the system medium and the endpoint of the TTI. For example, the endpoint at 8°C ranged from 6 to 2 days for inoculum levels of 101 and 106 CFU/ml, respectively. This relationship allows the easy adjustment of the TTI endpoint at a certain temperature according to the shelf life of the food product of concern by using an appropriate inoculum level of L. sakei. The microbial TTI prototype developed in the present study could be used as an effective tool for monitoring shelf life during the distribution and storage of food products that are spoiled primarily by lactic acid

  2. Development of a microbial time/temperature indicator prototype for monitoring the microbiological quality of chilled foods.

    PubMed

    Vaikousi, Hariklia; Biliaderis, Costas G; Koutsoumanis, Konstantinos P

    2008-05-01

    A time/temperature indicator (TTI) system based on the growth and metabolic activity of a Lactobacillus sakei strain was developed for monitoring food quality throughout the chilled-food chain. In the designed system, an irreversible color change of a chemical chromatic indicator (from red to yellow) progressively occurs due to the pH decline that results from microbial growth and metabolism in a selected medium. The relation of the TTI response (color change) to the growth and metabolic activity (glucose consumption, lactic acid production, pH decrease) of L. sakei was studied. In addition, the temperature dependence of the TTI kinetics was investigated isothermally in the range of 0 to 16 degrees C and modeled with a system of differential equations. At all temperatures tested, the pH and color changes of the TTI system followed closely the growth of L. sakei, with the endpoint (the time at which a distinct visual color change to the final yellow was observed) of the TTI coinciding with a population level of 10(7) to 10(8) CFU/ml. The endpoint decreased from 27 days at 0 degrees C to 2.5 days at 16 degrees C, yielding an activation energy of 97.7 kJ/mol, which was very close to the activation energy of the L. sakei growth rate in the TTI substrate (103.2 kJ/mol). Furthermore, experiments conducted on the effect of the inoculum level showed a negative linear relationship between the level of L. sakei inoculated in the system medium and the endpoint of the TTI. For example, the endpoint at 8 degrees C ranged from 6 to 2 days for inoculum levels of 10(1) and 10(6) CFU/ml, respectively. This relationship allows the easy adjustment of the TTI endpoint at a certain temperature according to the shelf life of the food product of concern by using an appropriate inoculum level of L. sakei. The microbial TTI prototype developed in the present study could be used as an effective tool for monitoring shelf life during the distribution and storage of food products that are

  3. Applicability of biological time temperature integrators as quality and safety indicators for meat products.

    PubMed

    Ellouze, M; Augustin, J-C

    2010-03-31

    The objective of this study was to evaluate (eO), a biological time temperature integrator (TTI) as a quality and safety indicator for ground beef packed under modified atmosphere and spiced cooked chicken slices packed under modified atmosphere. Storage trials and challenge tests were thus performed on several batches of the studied food to monitor and model the behavior of Listeria monocytogenes, Salmonella, Staphylococcus aureus and the indigenous food flora. Then, two different prototypes of the TTI (eO) were set and manufactured according to the studied products shelf lives. The TTI evolution with time at static and dynamic temperatures was monitored and modeled. Finally, exposure assessment models were set and used under several realistic storage profiles to assess the distributions of the concentration of the indigenous food flora and the distributions of the increase in the pathogens populations obtained at the end of the product shelf life or at the end point of the TTI, taking into account the TTIs batch variability. Results showed that in case of poor storage conditions, TTI can reduce the consumer exposure to altered or hazardous foods. PMID:20074826

  4. In vivo bioinsecticidal activity toward Ceratitis capitata (fruit fly) and Callosobruchus maculatus (cowpea weevil) and in vitro bioinsecticidal activity toward different orders of insect pests of a trypsin inhibitor purified from tamarind tree (Tamarindus indica) seeds.

    PubMed

    Araújo, Carina L; Bezerra, Ingrid W L; Oliveira, Adeliana S; Moura, Fabiano T; Macedo, Leonardo L P; Gomes, Carlos E M; Barbosa, Aulus E A D; Macedo, Francisco P; Souza, Tánia M S; Franco, Octavio L; Bloch-J, Carlos; Sales, Mauricio P

    2005-06-01

    A proteinaceous inhibitor with high activity against trypsin-like serine proteinases was purified from seeds of the tamarind tree (Tamarindus indica) by gel filtration on Shephacryl S-200 followed by a reverse-phase HPLC Vidac C18 TP. The inhibitor, called the tamarind trypsin inhibitor (TTI), showed a Mr of 21.42 kDa by mass spectrometry analysis. TTI was a noncompetitive inhibitor with a Ki value of 1.7 x 10(-9) M. In vitro bioinsecticidal activity against insect digestive enzymes from different orders showed that TTI had remarkable activity against enzymes from coleopteran, Anthonomus grandis (29.6%), Zabrotes subfasciatus (51.6%), Callosobruchus maculatus (86.7%), Rhyzopertha dominica(88.2%), and lepidopteron, Plodia interpuncptella (26.7%), Alabama argillacea (53.8%), and Spodoptera frugiperda (75.5%). Also, digestive enzymes from Diptera, Ceratitis capitata (fruit fly), were inhibited (52.9%). In vivo bioinsecticidal assays toward C. capitata and C. maculatus larvae were developed. The concentration of TTI (w/w) in the artificial seed necessary to cause 50% mortality (LD50) of larvae was 3.6%, and that to reduce mass larvae by 50.0% (ED50) was 3.2%. Furthermore, the mass C. capitata larvae were affected at 53.2% and produced approximately 34% mortality at a level of 4.0% (w/w) of TTI incorporated in artificial diets. PMID:15913299

  5. Time--temperature indicator for perishable products based on kinetically programmable Ag overgrowth on Au nanorods.

    PubMed

    Zhang, Chao; Yin, An-Xiang; Jiang, Ruibin; Rong, Jie; Dong, Lu; Zhao, Tian; Sun, Ling-Dong; Wang, Jianfang; Chen, Xing; Yan, Chun-Hua

    2013-05-28

    Food safety is a constant concern for humans. Besides adulteration and contamination, another major threat comes from the spontaneous spoilage of perishable products, which is basically inevitable and highly dependent on the temperature history during the custody chain. For advanced quality control and assessment, time-temperature indicators (TTIs) can be deployed to document the temperature history. However, the use of TTIs is currently limited by either relatively high cost or poor programmability. Here we describe a general, kinetically programmable, and cost-efficient TTI protocol constructed from plasmonic nanocrystals. We present proof-of-principle demonstrations that our TTI can be specifically tailored and thus used to track perishables, dynamically mimic the deteriorative processes therein, and indicate product quality through sharp-contrast multicolor changes. The flexible programmability of our TTI, combined with its substantially low cost and low toxicity, promises a general applicability to each single packaged item of a plethora of perishable products. PMID:23627773

  6. Integrated Science: Florida Manatees and Everglades Hydrology

    USGS Publications Warehouse

    Langtimm, Catherine A.; Swain, Eric D.; Stith, Bradley M.; Reid, James P.; Slone, Daniel H.; Decker, Jeremy; Butler, Susan M.; Doyle, Terry; Snow, R.W.

    2009-01-01

    Predicting and monitoring restoration effects on Florida manatees, which are known to make extended movements, will be incomplete if modeling and monitoring are limited to the smaller areas defined by the various res-toration components. U.S. Geological Survey (USGS) efforts, thus far, have focused on (1) collecting manatee movement data throughout the Ten Thousand Islands (TTI) region, and (2) developing an individual-based model for manatees to illustrate manatee responses to changes in hydrology related to the Picayune Strand Restoration Project (PSRP). In 2006, new regional research was begun to extend an Everglades hydrology model into the TTI region; extend the manatee movement model into the southern estuaries of Everglades National Park (ENP); and integrate hydrology and manatee data, models, and monitoring across the TTI region and ENP. Currently (2008), three research tasks are underway to develop the necessary modeling components to assess restoration efforts across the Greater Everglades Ecosystem.

  7. Orbit Determination Error Analysis Results for the Triana Sun-Earth L2 Libration Point Mission

    NASA Technical Reports Server (NTRS)

    Marr, G.

    2003-01-01

    Using the NASA Goddard Space Flight Center's Orbit Determination Error Analysis System (ODEAS), orbit determination error analysis results are presented for all phases of the Triana Sun-Earth L1 libration point mission and for the science data collection phase of a future Sun-Earth L2 libration point mission. The Triana spacecraft was nominally to be released by the Space Shuttle in a low Earth orbit, and this analysis focuses on that scenario. From the release orbit a transfer trajectory insertion (TTI) maneuver performed using a solid stage would increase the velocity be approximately 3.1 km/sec sending Triana on a direct trajectory to its mission orbit. The Triana mission orbit is a Sun-Earth L1 Lissajous orbit with a Sun-Earth-vehicle (SEV) angle between 4.0 and 15.0 degrees, which would be achieved after a Lissajous orbit insertion (LOI) maneuver at approximately launch plus 6 months. Because Triana was to be launched by the Space Shuttle, TTI could potentially occur over a 16 orbit range from low Earth orbit. This analysis was performed assuming TTI was performed from a low Earth orbit with an inclination of 28.5 degrees and assuming support from a combination of three Deep Space Network (DSN) stations, Goldstone, Canberra, and Madrid and four commercial Universal Space Network (USN) stations, Alaska, Hawaii, Perth, and Santiago. These ground stations would provide coherent two-way range and range rate tracking data usable for orbit determination. Larger range and range rate errors were assumed for the USN stations. Nominally, DSN support would end at TTI+144 hours assuming there were no USN problems. Post-TTI coverage for a range of TTI longitudes for a given nominal trajectory case were analyzed. The orbit determination error analysis after the first correction maneuver would be generally applicable to any libration point mission utilizing a direct trajectory.

  8. Advances in vaccine stability monitoring technology.

    PubMed

    Zweig, Stephen E

    2006-08-14

    Electronic time-temperature indicator (eTTI) monitors can be programmed to exactly follow the stability characteristics of vaccines with a high degree of realism. The monitors have a visual output, enabling vaccine status to be assessed at a glance, and can also output more detailed statistical data. When packaged with vaccine vials in groups of about 10 vials per box, the eTTI can remain with a vaccine throughout most of the vaccine's lifetime. The monitors can detect essentially all cold-chain breaks, and can detect issues, such as inadvertent freezing, that are presently not detected by other vaccine stability monitors such as Vaccine Vial Monitors (VVM). PMID:16759766

  9. Electrophysiology of Memory-Updating Differs with Age

    PubMed Central

    Steiner, Genevieve Z.; Gonsalvez, Craig J.; De Blasio, Frances M.; Barry, Robert J.

    2016-01-01

    In oddball tasks, the P3 component of the event-related potential systematically varies with the time between target stimuli—the target-to-target interval (TTI). Longer TTIs result in larger P3 amplitudes and shorter latencies, and this pattern of results has been linked with working memory-updating processes. Given that working memory and the P3 have both been shown to diminish with age, the current study aimed to determine whether the linear relationship between P3 and TTI is compromised in healthy aging by comparing TTI effects on P3 amplitudes and latencies, and reaction time (RT), in young and older adults. Older adults were found to have an overall reduction in P3 amplitudes, longer latencies, an anterior shift in topography, a trend toward slower RTs, and a flatter linear relationship between P3 and TTI than young adults. Results suggest that the ability to maintain templates in working memory required for stimulus categorization decreases with age, and that as a result, neural compensatory mechanisms are employed. PMID:27378908

  10. New TPEG applications based on digital multimedia broadcasting

    NASA Astrophysics Data System (ADS)

    Jeong, Youngho; Cho, Sammo; Kim, Geon; Ahn, Chunghyun; Lee, Sooin; Kim, Whanwoo

    2006-02-01

    The digital multimedia broadcasting (DMB) allows can provide an economical way of massive multimedia data services, thus, it is emerging as an optimal solution to address the several drawbacks of the mobile communication network. Among the data services based on the DMB, the traffic and travel Information (TTI) service has been spotlighted in aspects of economic influence and information usability. For example, the demand of TTI service has dramatically increased due to rapid increase in the number of vehicles and population of frequently traveling on long-weekends. In order to satisfying such a demanding, a transport protocol experts group (TPEG) protocol was developed. However, TPEG has been applied merely to two application areas up to now and there is no consideration to standardize new services very valuable for drivers and travelers. This paper presents new economic and effective point of interest (POI) and news services compatible to TPEG that can be provided in the DMB. To verify the stability of POI and news protocols, we implemented the TTI data server/client, and the DMB/DAB receiver with the TTI decoder. Through the experimental broadcasting in the local DMB network, it is shown that the proposed protocol operates stably and effectively in the navigation system.

  11. 14 CFR Appendix - Special Federal Aviation Regulation No. 109

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    .... Applicability. Contrary provisions of 14 CFR parts 21, 25, and 119 of this chapter notwithstanding, an applicant... of 14 CFR 91.533(b): (1) The number of flight attendants required by § 91.533(a)(1) and (2) of this... similar seat installation. TTI data must be acquired with a Side Impact Dummy (SID), as defined by 49...

  12. 14 CFR Appendix - Special Federal Aviation Regulation No. 109

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    .... Applicability. Contrary provisions of 14 CFR parts 21, 25, and 119 of this chapter notwithstanding, an applicant... of 14 CFR 91.533(b): (1) The number of flight attendants required by § 91.533(a)(1) and (2) of this... similar seat installation. TTI data must be acquired with a Side Impact Dummy (SID), as defined by 49...

  13. 78 FR 67303 - Americans With Disabilities Act (ADA) Accessibility Guidelines for Buildings and Facilities...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-12

    ... document that appeared in the Federal Register of September 26, 2013 (78 FR 59476). The document issued a... (TTY). Email address: board.gov ">raggio@access- board.gov . SUPPLEMENTARY INFORMATION: In FR Doc. 2013-22876 appearing on page 59476 in the Federal Register of Thursday, September 26, 2013 (78 FR 59476),...

  14. 76 FR 20297 - Implementing the Provisions of the Communications Act of 1934, as Enacted by the Twenty-First...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-12

    ..., ] Accessible Mobile Phone Options for People who are Blind, Deaf-Blind, or Have Low Vision, CG Docket No. 10... 76 FR 13800 (March 14, 2011). 2. On April 1, 2011, the American Foundation for the Blind, Consumer... phone: (202) 418-0530 or TTY: (202) 418-0432. FOR FURTHER INFORMATION CONTACT: Jeffrey Tignor,...

  15. The Illicit Use of Prescription Stimulants on College Campuses

    ERIC Educational Resources Information Center

    Bavarian, Niloofar; Flay, Brian R.; Ketcham, Patricia L.; Smit, Ellen

    2015-01-01

    The illicit use of prescription stimulants (IUPS) is a substance use behavior that remains prevalent on college campuses. As theory can guide research and practice, we provide a systematic review of the college-based IUPS epidemiological literature guided by one ecological framework, the theory of triadic influence (TTI). We aim to assess…

  16. Autophagy induction is a Tor- and Tp53-independent cell survival response in a zebrafish model of disrupted ribosome biogenesis.

    PubMed

    Boglev, Yeliz; Badrock, Andrew P; Trotter, Andrew J; Du, Qian; Richardson, Elsbeth J; Parslow, Adam C; Markmiller, Sebastian J; Hall, Nathan E; de Jong-Curtain, Tanya A; Ng, Annie Y; Verkade, Heather; Ober, Elke A; Field, Holly A; Shin, Donghun; Shin, Chong H; Hannan, Katherine M; Hannan, Ross D; Pearson, Richard B; Kim, Seok-Hyung; Ess, Kevin C; Lieschke, Graham J; Stainier, Didier Y R; Heath, Joan K

    2013-01-01

    Ribosome biogenesis underpins cell growth and division. Disruptions in ribosome biogenesis and translation initiation are deleterious to development and underlie a spectrum of diseases known collectively as ribosomopathies. Here, we describe a novel zebrafish mutant, titania (tti(s450)), which harbours a recessive lethal mutation in pwp2h, a gene encoding a protein component of the small subunit processome. The biochemical impacts of this lesion are decreased production of mature 18S rRNA molecules, activation of Tp53, and impaired ribosome biogenesis. In tti(s450), the growth of the endodermal organs, eyes, brain, and craniofacial structures is severely arrested and autophagy is up-regulated, allowing intestinal epithelial cells to evade cell death. Inhibiting autophagy in tti(s450) larvae markedly reduces their lifespan. Somewhat surprisingly, autophagy induction in tti(s450) larvae is independent of the state of the Tor pathway and proceeds unabated in Tp53-mutant larvae. These data demonstrate that autophagy is a survival mechanism invoked in response to ribosomal stress. This response may be of relevance to therapeutic strategies aimed at killing cancer cells by targeting ribosome biogenesis. In certain contexts, these treatments may promote autophagy and contribute to cancer cells evading cell death. PMID:23408911

  17. Medicare and You

    MedlinePlus

    ... gov/ ssa, and use the “Benefit Eligibility Screening Tool” to find out if you’re eligible for SSI or other benefits. Call Social Security at 1-800-772-1213 or contact your local Social Security office for more information. TTY users should call 1‑ ...

  18. Did You Have Gestational Diabetes When You Were Pregnant? What You Need to Know

    MedlinePlus

    ... play time in front of the computer, tablets, smartphones, and TV to 2 hours per day. Contact your local parks department or local health department to learn where you can find safe places to be active and get healthy foods. National Diabetes Education Program 1-800-860-8747, TTY: 1-866- ...

  19. 41 CFR Appendix A to Part 60 - 250-Guidelines on a Contractor's Duty To Provide Reasonable Accommodation

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...-6820 (TTY)), the Job Accommodation Network (JAN) operated by the Office of Disability Employment Policy... Commission (EEOC) implementing the ADA (29 CFR part 1630). Although the following discussion is intended to... the position. For instance, the contractor which has a security guard position which requires...

  20. 76 FR 53379 - Endangered and Threatened Wildlife and Plants; Revising the List of Endangered and Threatened...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-26

    ...) and revise the listing to conform to current statutory and policy requirements (76 FR 26086). In that... for TTY assistance. SUPPLEMENTARY INFORMATION: Background In our May 5, 2011, proposed rule (76 FR... FR 25590). This action became effective upon publication in the Federal Register. The May 5,...

  1. 75 FR 76714 - Combined Notice of Filings No. 2

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-09

    ... tariff filing per 35.15: CP Crane Cancellation Filing to be effective 12/2/2010. Filed Date: 12/01/2010...Support@ferc.gov . or call (866) 208-3676 (toll free). For TTY, call (202) 502-8659. Nathaniel J....

  2. 78 FR 26261 - Connect America Fund; Developing a Unified Intercarrier Compensation Regime

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-06

    ... (voice) or (202) 418-0432 (TTY). I. Introduction 1. In the USF/ICC Transformation Order, 76 FR 81,562... to ] determine the allocation of the Transport Interconnection Charge (TIC) among the various access....415 to clarify that the amount of a rate-of-return carrier's TIC costs to be reallocated to...

  3. 78 FR 34550 - Funding and Fiscal Affairs, Loan Policies and Operations, and Funding Operations; Accounting and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-10

    ... on April 9, 2013 (78 FR 21035) is effective June 3, 2013. FOR FURTHER INFORMATION CONTACT: Michael T. Wilson, Policy Analyst, Office of Regulatory Policy, Farm Credit Administration, McLean, VA 22102-5090... Credit Administration, McLean, Virginia 22102-5090, (703) 883-4431, TTY (703) 883-4056....

  4. 76 FR 31453 - Special Conditions: Gulfstream Model GVI Airplane; Single-Occupant Side-Facing Seats

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-01

    ... FR 291). No comments were received and these ] special conditions are adopted as proposed... energy absorbing protective padding (foam or equivalent), such as Ensolite. 3. Thoracic Trauma: Thoracic trauma index (TTI) injury criterion must be substantiated by dynamic test or by rational analysis...

  5. 78 FR 49514 - Sunshine Act Meeting; Open Commission Meeting; Friday, August 9, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-14

    ... frequency band to provide additional competition in the broadband market, improve efficient delivery of... obtained from Meribeth McCarrick, Office of Media Relations, (202) 418-0500; TTY 1- 888-835-5322. Audio... format and alternative media, including large print/ type; digital disk; and audio and video tape....

  6. 78 FR 28583 - Utility Bid USA, LLC: Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-15

    ... Energy Regulatory Commission Utility Bid USA, LLC: Supplemental Notice That Initial Market- Based Rate...-referenced proceeding, of Utility Bid USA, LLC's application for market-based rate authority, with an..., please email FERCOnlineSupport@ferc.gov . or call (866) 208-3676 (toll free). For TTY, call (202)...

  7. The Association between Attitude towards the Implementation of Staff Development Training and the Practice of Knowledge Sharing among Lecturers

    ERIC Educational Resources Information Center

    Kassim, Abd. Latif; Raman, Arumugam; Don, Yahya; Daud, Yaakob; Omar, Mohd Sofian

    2015-01-01

    This study was aimed to identify the association of teachers' attitude towards the implementation of Staff Development Training with Knowledge Sharing Practices among the lecturers of the Teacher Training Institution (TTI). In addition, this study was also to examine the differences in attitudes towards the implementation of Staff Development…

  8. 78 FR 4427 - Mortgage and Loan Insurance Programs Under the National Housing Act-Debenture Interest Rates

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-22

    ...; telephone (202) 402-4778 (this is not a toll-free number). Individuals with speech or hearing impairments may access this number through TTY by calling the toll-free Federal Information Relay Service at (800.... However, as a result of an amendment to section 224 of the Act, if an insurance claim relating to...

  9. 75 FR 37785 - Louisville Gas and Electric Company; Notice of Baseline Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-30

    ... Energy Regulatory Commission Louisville Gas and Electric Company; Notice of Baseline Filing June 23, 2010. Take notice that on June 21, 2010, Louisville Gas and Electric Company submitted a baseline filing of...Support@ferc.gov , or call (866) 208-3676 (toll free). For TTY, call (202) 502-8659. Comment Date: 5...

  10. 77 FR 47060 - Illinois Municipal Electric Agency; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-07

    ... Energy Regulatory Commission Illinois Municipal Electric Agency; Notice of Filing Take notice that on July 30, 2012, Illinois Municipal Electric Agency filed a Proposed Revenue Requirement for reactive... free). For TTY, call (202) 502-8659. Comment Date: 5:00 p.m. Eastern Time on August 20, 2012....

  11. 77 FR 11529 - Louisville Gas and Electric Company; Kentucky Utilities Company; Notice of Petition for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-27

    ... Energy Regulatory Commission Louisville Gas and Electric Company; Kentucky Utilities Company; Notice of... Gas and Electric Company and Kentucky Utilities Company, filed a Petition for Declaratory Order... (toll free). For TTY, call (202) 502-8659. Comment Date: 5 p.m. Eastern Time on March 15, 2012....

  12. 77 FR 47060 - Missouri Joint Municipal Electric Utility Commission; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-07

    ... Energy Regulatory Commission Missouri Joint Municipal Electric Utility Commission; Notice of Filing Take notice that on July 30, 2012, Missouri Joint Municipal Electric Utility Commission filed a Proposed...Support@ferc.gov , or call (866) 208-3676 (toll free). For TTY, call (202) 502-8659. Comment Date: 5:00...

  13. 77 FR 61594 - Missouri Joint Municipal Electric Utility Commission; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-10

    ... Energy Regulatory Commission Missouri Joint Municipal Electric Utility Commission; Notice of Filing Take notice that on October 1, 2012, Missouri Joint Municipal Electric Utility Commission filed its Revised..., please email FERCOnlineSupport@ferc.gov , or call (866) 208-3676 (toll free). For TTY, call (202)...

  14. 75 FR 81601 - North American Electric Reliability Corporation; Notice of Compliance Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-28

    ... Energy Regulatory Commission North American Electric Reliability Corporation; Notice of Compliance Filing December 20, 2010. Take notice that on December 1, 2010, North American Electric Reliability Corporation... free). For TTY, call (202) 502-8659. Comment Date: 5 p.m. Eastern Time on January 10, 2011. Kimberly...

  15. 78 FR 20313 - PPL Electric Utilities Corporation; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-04

    ... Energy Regulatory Commission PPL Electric Utilities Corporation; Notice of Filing Take notice that on March 26, 2013, PPL Electric Utilities Corporation (PPL) submitted to the Federal Energy Regulatory...Support@ferc.gov , or call (866) 208-3676 (toll free). For TTY, call (202) 502-8659. Comment Date: 5:00...

  16. 75 FR 67960 - North American Electric Reliability Corporation; Notice of Compliance Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-04

    ... Energy Regulatory Commission North American Electric Reliability Corporation; Notice of Compliance Filing October 28, 2010. Take notice that on October 25, 2010, the North American Electric Reliability... FERCOnlineSupport@ferc.gov , or call (866) 208-3676 (toll free). For TTY, call (202) 502-8659. Comment...

  17. 75 FR 19957 - New York State Electric & Gas Corporation; Notice of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-16

    ... Energy Regulatory Commission New York State Electric & Gas Corporation; Notice of Application April 9, 2010. Take notice that on March 24, 2010, New York State Electric & Gas Corporation (NYSEG), filed with... FERCOnlineSupport@ferc.gov or call (866) 208-3676 (toll free). For TTY, call (202) 502-8659. Comment...

  18. 78 FR 18333 - North American Electric Reliability Corporation; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... Energy Regulatory Commission North American Electric Reliability Corporation; Notice of Filing Take notice that on March 11, 2013, the North American Electric Reliability Corporation and SERC Reliability..., please email FERCOnlineSupport@ferc.gov , or call (866) 208-3676 (toll free). For TTY, call (202)...

  19. 77 FR 61596 - Illinois Electric Agency; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-10

    ... Energy Regulatory Commission Illinois Electric Agency; Notice of Filing Take notice that on October 1, 2012, Illinois Electric Agency filed its Revised and Superseding Proposed Revenue Requirement for... (toll free). For TTY, call (202) 502-8659. Comment Date: 5 p.m. Eastern Time on October 22, 2012....

  20. 76 FR 56194 - Pacific Gas and Electric Company; Notice of Rate Election

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-12

    ... Energy Regulatory Commission Pacific Gas and Electric Company; Notice of Rate Election Take notice that on September 2, 2011, Pacific Gas and Electric Company (PG&E) filed a new Rate Election and an... FERCOnlineSupport@ferc.gov or call (866) 208-3676 (toll free). For TTY, call (202) 502-8659. Comment Date:...

  1. 76 FR 62802 - North American Electric Reliability Corporation; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-11

    ... Energy Regulatory Commission North American Electric Reliability Corporation; Notice of Filing Take notice that on September 30, 2011, the North American Electric Reliability Corporation (NERC) filed a..., please e-mail FERCOnlineSupport@ferc.gov , or call (866) 208-3676 (toll free). For TTY, call (202)...

  2. 77 FR 25162 - Golden Spread Electric Cooperative, Inc. v. Southwestern Public Service Company; Notice of Complaint

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-27

    ... Federal Energy Regulatory Commission Golden Spread Electric Cooperative, Inc. v. Southwestern Public... Electric Cooperative, Inc. (Complainant or Golden Spread) filed a formal complaint against Southwestern...Support@ferc.gov , or call (866) 208-3676 (toll free). For TTY, call (202) 502-8659. Comment Date: 5...

  3. 78 FR 9686 - Valley Electric Association, Inc.; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-11

    ... Energy Regulatory Commission Valley Electric Association, Inc.; Notice of Filing Take notice that on February 1, 2013, Valley Electric Association, Inc. filed a notice of material changes in certain of the...Support@ferc.gov , or call (866) 208-3676 (toll free). For TTY, call (202) 502-8659. Comment Date: 5:00...

  4. 77 FR 13589 - Seminole Electric Cooperative, Inc. and Florida Municipal Power Agency v.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-07

    ... Energy Regulatory Commission Seminole Electric Cooperative, Inc. and Florida Municipal Power Agency v....206 (2011), Seminole Electric Cooperative, Inc. and Florida Municipal Power Agency (Complainants...Support@ferc.gov , or call (866) 208-3676 (toll free). For TTY, call (202) 502-8659. Comment Date: 5...

  5. 75 FR 27338 - San Diego Gas & Electric Company; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission San Diego Gas & Electric Company; Notice of Filing May 7, 2010. Take notice...Support@ferc.gov , or call (866) 208-3676 (toll free). For TTY, call (202) 502-8659. Comment Date: 5...

  6. 76 FR 36533 - Bangor Hydro Electric Company; Notice of Request for Waiver

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-22

    ... Energy Regulatory Commission Bangor Hydro Electric Company; Notice of Request for Waiver Take notice that...), Bangor Hydro Electric Company (Bangor Hydro) requests a limited waiver of Part 358 of the Commission's...) 208-3676 (toll free). For TTY, call (202) 502-8659. Comment Date: 5 p.m. Eastern Time on June 23,...

  7. 75 FR 4374 - North American Electric Reliability Corporation; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-27

    ... Energy Regulatory Commission North American Electric Reliability Corporation; Notice of Filing January 20, 2010. Take notice that on January 19, 2010, North American Electric Reliability Corporation (NERC... , or call (866) 208-3676 (toll free). For TTY, call (202) 502-8659. Comment Date: 5 p.m. Eastern...

  8. 77 FR 38623 - NSTAR Electric Company; Notice of Request for Waiver or Exemption

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-28

    ... Energy Regulatory Commission NSTAR Electric Company; Notice of Request for Waiver or Exemption Take notice that on October 1, 2010, NSTAR Electric Company filed a petition requesting full waiver or..., please email FERCOnlineSupport@ferc.gov . or call (866) 208-3676 (toll free). For TTY, call (202)...

  9. Bio-potency of a 21 kDa Kunitz-type trypsin inhibitor from Tamarindus indica seeds on the developmental physiology of H. armigera.

    PubMed

    Pandey, Prabhash K; Jamal, Farrukh

    2014-11-01

    A trypsin inhibitor purified from the seeds of Tamarindus indica by Sephadex G-75, DEAE-Sepharose and Trypsin-Sepharose CL-4B columns was studied for its antifeedant, larvicidal, pupicidal and growth inhibitory activities against Helicoverpa armigera larvae. Tamarindus trypsin inhibitor (TTI) exhibited inhibitory activity towards total gut proteolytic enzymes of H. armigera (~87%) and bovine trypsin (~84%). Lethal doses which caused mortality and weight reduction by 50% were 1% w/w and 0.50% w/w, respectively. IC50 of TTI against Helicoverpa midgut proteases and bovine trypsin were ~2.10 µg/ml and 1.68 µg/ml respectively. In larval feeding studies the 21 kDa Kunitz-type protein was found to retard growth and development, prolonged the larval-pupal development durations along with adversely affecting the fertility and fecundity of H. armigera. In artificial diet at 0.5% w/w TTI, the efficiency of conversion of ingested food as well as of digested food, relative growth rate, growth index declined whereas approximate digestibility, metabolic cost, relative consumption rate, consumption index and total developmental period enhanced for H. armigera larvae. These results suggest that TTI has toxic and adverse effect on the developmental physiology of H. armigera and could be useful in controlling the pest H. armigera. PMID:25454525

  10. 76 FR 42461 - Consolidated Delegation of Authority to the General Counsel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-18

    ... through TTY by calling 1-800-877- 8339. SUPPLEMENTARY INFORMATION: On December 1, 2009, at 74 FR 62801... Property Rights, issued March 15, 1987, (53 FR 8859, March 18, 1988) consistent with Executive Order 13406, Protecting the Property Rights of the American People, issued June 23, 2006 (71 FR 36973, June 28, 2006)....

  11. What Works Clearinghouse Quick Review: "Transfer Incentives for High-Performing Teachers: Final Results from a Multisite Experiment"

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2014

    2014-01-01

    "Transfer Incentives for High-Performing Teachers: Final Results from a Multisite Experiment," examined the impact of the Talent Transfer Initiative (TTI) on both student achievement and teacher retention in 10 school districts across seven states. The initiative gave bonuses to high-performing teachers for them to transfer to and stay…

  12. 14 CFR 382.151 - What are the requirements for providing Complaints Resolution Officials?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false What are the requirements for providing Complaints Resolution Officials? 382.151 Section 382.151 Aeronautics and Space OFFICE OF THE SECRETARY... passenger. If a telephone link to the CRO is used, TTY service or a similarly effective technology must...

  13. 49 CFR 39.103 - What actions do CROs take on complaints?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false What actions do CROs take on complaints? 39.103... CROs take on complaints? When a complaint is made directly to a CRO (e.g., orally, by phone, TTY) the CRO must promptly take dispositive action as follows: (a) If the complaint is made to a CRO before...

  14. 49 CFR 39.101 - What are the requirements for providing Complaints Resolution Officials?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... designate one or more Complaints Resolution Officials (CROs). (b) You must make a CRO available for contact on each vessel and at each terminal that you serve. The CRO may be made available in person or via telephone, if at no cost to the passenger. If a telephone link to the CRO is used, TTY or TRS service...

  15. 78 FR 32709 - Open Meeting of the Federal Advisory Committee on Insurance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ... difficulty hearing or speaking may access this number via TTY by calling the toll-free Federal Relay Service... public inspection and copying in the Department of the Treasury's Library, 1500 Pennsylvania Avenue NW... Open Meeting of the Federal Advisory Committee on Insurance AGENCY: Departmental Offices,...

  16. 78 FR 54371 - Open Meeting of the Federal Advisory Committee on Insurance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-03

    ...-free number). Persons who have difficulty hearing or speaking may access this number via TTY by calling... the Treasury's Library, 1500 Pennsylvania Avenue NW., Washington, DC 20220, on official business days... Open Meeting of the Federal Advisory Committee on Insurance AGENCY: Departmental Offices,...

  17. 77 FR 64514 - Sunshine Act Meeting; Open Commission Meeting; Wednesday, October 17, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    ... (WT Docket No. 07- COMMUNICATIONS. 293); Establishment of Rules and Policies for the Digital Audio...; TTY 1- 888-835-5322. Audio/Video coverage of the meeting will be broadcast live with open captioning... copies are available in paper format and alternative media, including large print/ type; digital...

  18. 78 FR 28749 - Private Land Mobile Radio Stations Below 800 MHz

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-16

    ... (tty). 1. In the Second Report and Order, at 75 FR 19277, April 14, 2010, in this proceeding, the...), at 75 FR 19340, April 14, 2010, proposed various changes to the PLMR licensing and service rules... monitoring. We also remove unnecessary language from Sec. Sec. 90.187(b)(2)(v) (which, redundantly of Sec....

  19. 76 FR 7562 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-10

    ... in advance on future Commission sessions). Please telephone (202) 663-7100 (voice) and (202) 663-4074... Communication Access Realtime Translation (CART) services at Commission meetings for the hearing impaired. Requests for other reasonable accommodations may be made by using the voice and TTY numbers listed...

  20. 75 FR 62815 - Sunshine Act; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-13

    ... in advance on future Commission sessions.) Please telephone (202) 663-7100 (voice) and (202) 663-4074... Communication Access Realtime Translation (CART) services at Commission meetings for the hearing impaired. Requests for other reasonable accommodations may be made by using the voice and TTY numbers listed...

  1. 77 FR 9653 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-17

    ... in advance on future Commission sessions.) Please telephone (202) 663-7100 (voice) and (202) 663-4074... Communication Access Realtime Translation (CART) services at Commission meetings for the hearing impaired. Requests for other reasonable accommodations may be made by using the voice and TTY numbers listed...

  2. 76 FR 77996 - FFP Project 9 LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-15

    ...-hours. Applicant Contact: Ms. Ramya Swaminathan, Free Flow Power Corp., 239 Causeway Street, Suite 300... consist of: (1) A 23,400-foot-long, 64- foot-high earthen dam; (2) a reservoir with a surface area of 32... Support at FERCOnlineSupport@ferc.gov or toll free at 1-(866) 208-3676, or for TTY, (202)...

  3. 78 FR 35019 - FFP Project 58, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-11

    ... Swaminathan, Free Flow Power Corporation, 239 Causeway Street, Suite 300, Boston, MA 02114. (978) 283-2822...- foot-long, 34-foot-high timber crib dam; (2) a reservoir with a surface area of 940 acres and a storage... toll free at 1-866-208-3676, or for TTY, (202) 502-8659. Although the Commission strongly...

  4. 78 FR 30917 - FFP Project 115, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-23

    ... Contact: Ms. Ramya Swaminathan, Free Flow Power Corporation, 239 Causeway Street, Suite 300, Boston, MA...- foot-long, 36-foot-high timber dam; (2) a reservoir with a surface area of 730 acres and a storage... Support at FERCOnlineSupport@ferc.gov or toll free at 1-866-208-3676, or for TTY, (202) 502-8659....

  5. 78 FR 5175 - Combined Notice of Filings #2

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-24

    ... Mohawk Power Corporation submits tariff filing per 35.13(a)(2)(iii: SA No. 1949 NiMo and EDGE Corp... detailed information relating to filing requirements, interventions, protests, service, and qualifying... information, call (866) 208-3676 (toll free). For TTY, call (202) 502-8659. Dated: January 15, 2013....

  6. 77 FR 20474 - Delegation of Authority; Delegation of Authority No. 24 to the Chief Operating Officer

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-04

    ... limited exceptions noted below, over the Office of the Chief Information Officer and the Office of... officers within the Agency so as to achieve the mission and goals of the Agency. ] FOR FURTHER INFORMATION... TTY by calling 1- 704-344-6640. SUPPLEMENTARY INFORMATION: Certain management, program and...

  7. 78 FR 25264 - Southern Star Central Gas Pipeline, Inc.; Notice of Request Under Blanket Authorization

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-30

    ... Energy Regulatory Commission Southern Star Central Gas Pipeline, Inc.; Notice of Request Under Blanket Authorization Take notice that on April 16, 2013, Southern Star Central Gas Pipeline, Inc. (Southern Star), 4700...) 208-3676 (toll free). For TTY, call (202) 502-8659. Specifically, Southern Star proposes to abandon...

  8. 77 FR 18258 - Notice of FHA Debenture Call

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-27

    ... URBAN DEVELOPMENT Notice of FHA Debenture Call AGENCY: Office of the Assistant Secretary for Housing--Federal Housing Commissioner, HUD. ACTION: Notice. SUMMARY: This Notice announces a debenture call of... impairments may access this number through TTY by calling the toll-free Federal Relay Service at...

  9. 78 FR 69403 - South Tahoe Public Utility District; Notice of Preliminary Determination of a Qualifying Conduit...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-19

    ... consumption and not primarily for the generation of electricity. FPA 30(a)(3)(C)(i), as amended by HREA... Online Support at FERCOnlineSupport@ferc.gov , (866) 208-3676 (toll free), or (202) 502-8659 (TTY). In... access the document. For assistance, call toll- free 1-866-208-3676 or email...

  10. 77 FR 28592 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-15

    .... Description: Application of FirstEnergy Solutions Corp. for authorization to sell electricity at wholesale to.... Description: Application of FirstEnergy Solutions Corp. for authorization to sell electricity at wholesale to... other information, call (866) 208-3676 (toll free). For TTY, call (202) 502-8659. Dated: May 8,...

  11. 77 FR 35060 - Employment and Training Administration; Proposed Information Collection Request for the ETA 538...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-12

    ... addresses section below on or before August 13, 2012. ADDRESSES: Submit written comments to Scott Gibbons... toll-free Federal Information Relay Service at 1-877-889-5627 (TTY/TDD). Email: gibbons.scott@dol.gov.... Gibbons. SUPPLEMENTARY INFORMATION: I. Background The ETA 538 and ETA 539 reports are weekly reports...

  12. 77 FR 73053 - Comment Request for Information Collection on Administrative Procedures Including Form MA 8-7...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-07

    ... February 5, 2013. ADDRESSES: Submit written comments to Scott Gibbons, Office of Unemployment Insurance... Information Relay Service at 1-877-889-5627 (TTY/TDD). Email: gibbons.scott@dol.gov . A copy of the proposed information collection request (ICR) can be obtained by contacting Mr. Gibbons. SUPPLEMENTARY INFORMATION:...

  13. 77 FR 31879 - Comment Request for Information Collection for 1205-0179: Unemployment Compensation for Federal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-30

    ... 30, 2012. ADDRESSES: Submit written comments to Scott Gibbons, Office of Unemployment Insurance... Information Relay Service at 1-877-889-5627 (TTY/TDD). Email: gibbons.scott@dol.gov . A copy of the proposed information collection request (ICR) can be obtained by contacting Mr. Gibbons. SUPPLEMENTARY INFORMATION:...

  14. 77 FR 69503 - Comment Request for Information Collection on the ETA 218, Benefit Rights and Experience Report...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-19

    ... January 18, 2013. ADDRESSES: Submit written comments to Scott Gibbons, Office of Unemployment Insurance... Information Relay Service at 1-877-889-5627 (TTY/TDD). Email: gibbons.scott@dol.gov . A copy of the proposed information collection request (ICR) can be obtained by contacting Mr. Gibbons. SUPPLEMENTARY INFORMATION:...

  15. 77 FR 70833 - Comment Request for Information Collection on the ETA 9048, Worker Profiling and Reemployment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-27

    ...: Submit written comments to Scott Gibbons, Office of Unemployment Insurance, Employment and Training...-877-889-5627 (TTY/TDD). Email: gibbons.scott@dol.gov . A copy of the proposed information collection request (ICR) can be obtained by contacting Mr. Gibbons. SUPPLEMENTARY INFORMATION: I. Background...

  16. 76 FR 56749 - Northern Laramie Range Alliance; Notice of Petition for Declaratory Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-14

    ... Energy Regulatory Commission Northern Laramie Range Alliance; Notice of Petition for Declaratory Order Take notice that on July 12, 2011, Northern Laramie Range Alliance filed a Petition for Declaratory...Support@ferc.gov , or call (866) 208-3676 (toll free). For TTY, call (202) 502-8659. Comment Date: 5...

  17. 78 FR 36563 - 30-Day Notice of Proposed Information Collection: Single Family Premium Collection Subsystem...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-18

    ... URBAN DEVELOPMENT 30-Day Notice of Proposed Information Collection: Single Family Premium Collection... to the proposal by name and/or OMB Control Number and should be sent to: HUD Desk Officer, Office of... access this number through TTY by calling the toll-free Federal Relay Service at (800) 877-8339. This...

  18. 78 FR 52782 - 30-Day Notice of Proposed Information Collection: Mortgage Insurance Termination; Application for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-26

    ...; Application for Premium Refund or Distributive Share Payment AGENCY: Office of the Chief Information Officer... regarding this proposal. Comments should refer to the proposal by name and/or OMB Control Number and should...-3400. Persons with hearing or speech impairments may access this number through TTY by calling the...

  19. 78 FR 55281 - 60-Day Notice of Proposed Information Collection: Quality Control for Rental Assistance Subsidy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-10

    ... will provide current information on the quality of tenant interviews (e.g., whether they are being... speech impairments may access this number through TTY by calling the toll-free Federal Relay Service at... respondent burden (e.g., permitting electronic submission of responses). A. Overview of...

  20. Systematized contact between inventors and industry. [Final Technical Report

    SciTech Connect

    Not Available

    1992-07-31

    A total of 139 inventions by private (individual) inventors were submitted to Technology Targeting Incorporated. Each inventor was told of the nature of the DOE-supported Project, through informational and promotional efforts by TTI, and each completed an Invention Submittal Form developed by TTI to describe the essential nature of the claimed invention. Many also submitted detailed descriptions, drawings, technical reports and similar supplemental materials giving a more comprehensive view of their inventions. Each invention was reviewed for technical and commercial merit, as well as for appropriateness of marketing through the Technology Targeting DataBase[trademark] (hereafter DATABASE). Overall, participating inventors were enthusiastic about the Project and felt participation in it was rewording. Even when not selected for marketing, inventors were given an analysis of their inventions which could help them enhance the inventions and improve marketing efforts. Inventors whose inventions were selected for marketing were shown how to professionally market the inventions, including the format for Non Confidential Invention Summaries, the preferred form for Confidential Disclosure Agreements, targeting of business decision-makers responsible for technology evaluation, and the like; some of these inventors are still interacting with industrial contacts provided by TTI through this Project. All inventors received copies of patent abstracts uncovered in the prior art searches for their inventions and a copy of TTI's booklet, Patent Law Basics for Individual Inventors.

  1. Systematized contact between inventors and industry. Final technical report

    SciTech Connect

    Not Available

    1992-07-31

    A total of 139 inventions by private (individual) inventors were submitted to Technology Targeting Incorporated. Each inventor was told of the nature of the DOE-supported Project, through informational and promotional efforts by TTI, and each completed an Invention Submittal Form developed by TTI to describe the essential nature of the claimed invention. Many also submitted detailed descriptions, drawings, technical reports and similar supplemental materials giving a more comprehensive view of their inventions. Each invention was reviewed for technical and commercial merit, as well as for appropriateness of marketing through the Technology Targeting DataBase{trademark} (hereafter ``DATABASE). Overall, participating inventors were enthusiastic about the Project and felt participation in it was rewording. Even when not selected for marketing, inventors were given an analysis of their inventions which could help them enhance the inventions and improve marketing efforts. Inventors whose inventions were selected for marketing were shown how to professionally market the inventions, including the format for Non Confidential Invention Summaries, the preferred form for Confidential Disclosure Agreements, targeting of business decision-makers responsible for technology evaluation, and the like; some of these inventors are still interacting with industrial contacts provided by TTI through this Project. All inventors received copies of patent abstracts uncovered in the prior art searches for their inventions and a copy of TTI`s booklet, Patent Law Basics for Individual Inventors.

  2. 75 FR 33321 - Federal Property Suitable as Facilities To Assist the Homeless

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-11

    ...) 708-1234; TTY number for the hearing- and speech-impaired (202) 708-2565 (these telephone numbers are.... Title V, Federal Surplus Property Program Federal Register Report For 06/11/2010 Unsuitable Properties... Agency: Army Property Number: 21201020011 Status: Unutilized Reasons: Extensive deterioration Maryland...

  3. Daily Bladder Diary

    MedlinePlus

    ... page you would like to print out: View page 1 of the Bladder Diary View page 2 of the Bladder Diary This content is ... Information Center Phone: 1-800-860-8747 | TTY: 1-866-569-1162 | Email: healthinfo@niddk.nih.gov | Hours: 8:30 a.m. to 5 p.m. Eastern time, M-F

  4. 76 FR 9757 - Information Collection; Submission for OMB Review, Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-22

    ... for the Corporation for National and Community Service; and (2) Electronically by e-mail to: smar@omb... by calling the Corporation for National and Community Service, Bruce Kellogg, at (202) 606-6954 or e-mail to bkellogg@cns.gov . Individuals who use a telecommunications device for the deaf (TTY-TDD)...

  5. 76 FR 20961 - Information Collection; Submission for OMB Review, Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-14

    ... e-mail to ndietz@cns.gov . Individuals who use a telecommunications device for the deaf (TTY-TDD... for the Corporation for National and Community Service; and (2) Electronically by e-mail to smar@omb..., mechanical, or other technological collection techniques or other forms of information technology,...

  6. 7 CFR 510.3 - Requests for records.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Coordinator, Information Staff, ARS, REE, USDA, Mail Stop 5128, 5601 Sunnyside Avenue, Beltsville, MD 20705-5128; Telephone (301) 504-1640 or (301) 504-1655; TTY-VOICE (301) 504-1743; Facsimile (301) 504-1648; e-mail vherberger@ars.usda.gov or shutchison@ars.usda.gov. The FOIA Coordinator is delegated authority...

  7. Sequential Processing and the Matching-Stimulus Interval Effect in ERP Components: An Exploration of the Mechanism Using Multiple Regression

    PubMed Central

    Steiner, Genevieve Z.; Barry, Robert J.; Gonsalvez, Craig J.

    2016-01-01

    In oddball tasks, increasing the time between stimuli within a particular condition (target-to-target interval, TTI; nontarget-to-nontarget interval, NNI) systematically enhances N1, P2, and P300 event-related potential (ERP) component amplitudes. This study examined the mechanism underpinning these effects in ERP components recorded from 28 adults who completed a conventional three-tone oddball task. Bivariate correlations, partial correlations and multiple regression explored component changes due to preceding ERP component amplitudes and intervals found within the stimulus series, rather than constraining the task with experimentally constructed intervals, which has been adequately explored in prior studies. Multiple regression showed that for targets, N1 and TTI predicted N2, TTI predicted P3a and P3b, and Processing Negativity (PN), P3b, and TTI predicted reaction time. For rare nontargets, P1 predicted N1, NNI predicted N2, and N1 predicted Slow Wave (SW). Findings show that the mechanism is operating on separate stages of stimulus-processing, suggestive of either increased activation within a number of stimulus-specific pathways, or very long component generator recovery cycles. These results demonstrate the extent to which matching-stimulus intervals influence ERP component amplitudes and behavior in a three-tone oddball task, and should be taken into account when designing similar studies. PMID:27445774

  8. Technology Transfer and Innovation Initiatives in Strategic Management: Generating an Alternative Perspective

    ERIC Educational Resources Information Center

    Major, E.

    2003-01-01

    This paper taps the strategic management discipline to inform our understanding of technology transfer and innovation (TTI) initiatives. With special focus on the UK Foresight programme it considers the impacts that the resource-based and core competence approaches to strategy can have on understanding the nature and effectiveness of TTI…

  9. 77 FR 46086 - Commission Information Collection Activities (FERC-576); Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-02

    ... Register (77 FR 28369, May 14, 2012) requesting public comments. FERC received no comments on the FERC-576...-8659 for TTY. Docket: Users interested in receiving automatic notification of activity in this docket... Commission of: (1) Damage to jurisdictional natural gas facilities as a result of a hurricane, earthquake,...

  10. The text telephone as an empowering technology in the daily lives of deaf people-A qualitative study.

    PubMed

    Roos, Carin; Wengelin, Åsa

    2016-01-01

    Text-telephone technology (TTY) has been used for communication between deaf people since 1964. There is a gap in the scientific knowledge about the influence this may have had especially in relation to effective participation in society as well as the feeling of capability, confidence and collective meaningfulness. The aim of the present paper is, first, to disentangle the different aspects of TTY as an empowering artifact; and, second, to explore the role of TTY in their lives. To provide a framework for the empirical analysis, the paper draws on Empowerment Theory: personal control, a proactive approach to life, and a critical awareness of one's socio-political environment. Twenty-four people aged 16-64 with Swedish Sign Language (SSL) as their first language were interviewed. The findings indicate that the introduction of the TTY was of great importance for self-esteem, equality and independence. The findings show that feelings of empowerment are closely linked to language use and contextually driven, and it is in interaction between deaf and hearing that such feelings arise (or not). The results indicate the need for further research into Deaf people's use of other means of interacting, using modern technique for example in social digital media and interactive platforms. PMID:26479953

  11. 78 FR 27208 - Applications for New Awards; Rehabilitation Services Administration-Centers for Independent Living

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-09

    ... consumers who achieve their individual goals in the first two areas and on the percentage of their staff... for the deaf (TDD) or a text telephone (TTY), call, toll free: 1-877-576-7734. You can contact ED Pubs.... Individuals with disabilities can obtain a copy of the application package in an accessible format...

  12. 49 CFR 39.103 - What actions do CROs take on complaints?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false What actions do CROs take on complaints? 39.103... CROs take on complaints? When a complaint is made directly to a CRO (e.g., orally, by phone, TTY) the CRO must promptly take dispositive action as follows: (a) If the complaint is made to a CRO before...

  13. 75 FR 27660 - Loan Policies and Operations; Loan Purchases From FDIC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-18

    ..., Deputy Director, Office of Regulatory Policy, Farm Credit Administration, 1501 Farm Credit Drive, McLean, VA 22102-5090. You may review copies of all comments we receive at our office in McLean, Virginia, or... Administration, McLean, VA 22102-5090, (703) 883-4498, TTY (703) 883-4434, or Mary Alice Donner, Senior...

  14. 76 FR 5160 - Emergency Access Advisory Committee; Announcement of Date of Second Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-28

    ..., large print, electronic files, audio format), send an e-mail to fcc504@fcc.gov or call the Consumer and..., 202-418-2284 (voice) or 202-418-0416 (TTY), Cheryl.King@fcc.gov (e-mail) or Patrick Donovan, Public....gov (e-mail). SUPPLEMENTARY INFORMATION: On December 7, 2010, in document DA 10-2318, Chairman...

  15. 76 FR 63300 - Emergency Access Advisory Committee; Announcement of Date of Next Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-12

    ... disabilities (Braille, large print, electronic files, audio format), send an e-mail to fcc504@fcc.gov or call...-2284 (voice) or 202-418-0416 (TTY), e-mail: Cheryl.King@fcc.gov and/or Patrick Donovan, Public Safety and Homeland Security Bureau, 202-418-2413, e-mail: Patrick.Donovan@fcc.gov ....

  16. 75 FR 63452 - Lobo Pipeline Company L.P.; Notice of Baseline Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-15

    ... Energy Regulatory Commission Lobo Pipeline Company L.P.; Notice of Baseline Filing October 7, 2010. Take notice that on October 1, 2010, Lobo Pipeline Company L.P. submitted a revised baseline filing of its...Support@ferc.gov , or call (866) 208-3676 (toll free). For TTY, call (202) 502-8659. Comment Date: 5...

  17. 78 FR 18973 - Bridgeline Holdings, L.P.; Notice of Petition for Rate Approval

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-28

    ... Energy Regulatory Commission Bridgeline Holdings, L.P.; Notice of Petition for Rate Approval Take notice that on February 28, 2013, as supplemented on March 12, 2013, Bridgeline Holdings, L.P. filed for... free). For TTY, call (202) 502-8659. Comment Date: 5:00 p.m. Eastern Time on Monday, April 1,...

  18. 77 FR 70432 - Magic Valley Pipeline, L.P.; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-26

    ... Energy Regulatory Commission Magic Valley Pipeline, L.P.; Notice of Filing Take notice that on November 15, 2012, Magic Valley Pipeline, L.P. (Magic Valley) filed to revise its Statement of Operating... free). For TTY, call (202) 502-8659. Comment Date: 5:00 p.m. Eastern Time on Tuesday, November 27,...

  19. 77 FR 44610 - Enbridge Pipelines (North Texas) L.P.; Notice of Compliance Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-30

    ... Federal Energy Regulatory Commission Enbridge Pipelines (North Texas) L.P.; Notice of Compliance Filing Take notice that on July 13, 2012, Enbridge Pipelines (North Texas) L.P. filed a revised Statement of... TTY, call (202) 502-8659. Comment Date: 5:00 p.m. Eastern Time on Monday, July 30, 2012. Dated:...

  20. 76 FR 63188 - Notification of Employee Rights Under the National Labor Relations Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-12

    ... date of the final rule published at 76 FR 54006, August 30, 2011, is delayed from November 14, 2011 to...), 1-866-315-6572 (TTY/TDD). SUPPLEMENTARY INFORMATION: On August 30, 2011 (76 FR 54006), the National... National Labor Relations Act, further public education and outreach efforts would be helpful. The Board...

  1. 76 FR 68759 - GSA Approves Renewal of North American Numbering Council Charter Through September 23, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-07

    ... recommendations, such as the NANC's proposed method of selecting a Local Number Portability Administrator. In...@fcc.gov . The fax number is: (202) 418-1413. The TTY number is: (202) 418-0484. SUPPLEMENTARY... recommendations to the Commission will facilitate fair and efficient number administration in the United...

  2. 76 FR 6787 - Next Meeting of the North American Numbering Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-08

    ... LNP Database, Platform and Services Provider(s) 9. Report of the North American Portability Management LLC (NAPM LLC) 10. Report of the Local Number Portability Administration (LNPA) Working Group 11... fax number is: (202) 418-1413. The TTY number is: (202) 418-0484. SUPPLEMENTARY INFORMATION: This is...

  3. 75 FR 74051 - Next Meeting of the North American Numbering Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-30

    ... American Portability Management LLC (NAPM LLC) --Process for Procurement of Local Number Portability Administration Contract ] 9. Report of the Local Number Portability Administration (LNPA) Working Group 10... fax number is: (202) 418-1413. The TTY number is: (202) 418-0484. SUPPLEMENTARY INFORMATION: This is...

  4. 78 FR 34660 - Next Meeting of the North American Numbering Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-10

    ... Selection Working Group (SWG) 10. Report of the Local Number Portability Administration (LNPA) Working Group... CONTACT: Carmell Weathers at (202) 418-2325 or Carmell.Weathers@fcc.gov . The fax number is: (202) 418-1413. The TTY number is: (202) 418-0484. SUPPLEMENTARY INFORMATION: This is a summary of the...

  5. 77 FR 54577 - Next Meeting of the North American Numbering Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-05

    ... North American Portability Management LLC (NAPM LLC) 9. Report of the LNPA Selection Working Group (SWG) 10. Report of the Local Number Portability Administration (LNPA) Working Group 11. Status of the... Deborah.Blue@fcc.gov . The fax number is: (202) 418-1413. The TTY number is: (202) 418-0484....

  6. 78 FR 77449 - GSA Approves Renewal of North American Numbering Council Charter Through September 20, 2015

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-23

    ... Number Portability Administrator contract. The NANC also submitted recommendations on ways to improve....weathers@fcc.gov . The fax number is: (202) 418-1413. The TTY number is: 1-888-835-5322. SUPPLEMENTARY... Communications Commission (Commission) on rapidly evolving and significant number administration issues...

  7. 75 FR 61140 - Next Meeting of the North American Numbering Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-04

    ...). 7. Report of the Local Number Portability Administration (LNPA) Working Group. 8. Report of North American Portability Management LLC (NAPM LLC). 9. Report of the Telcordia Dispute Resolution Team... fax number is: (202) 418-1413. The TTY number is: (202) 418-0484. SUPPLEMENTARY INFORMATION: This is...

  8. 76 FR 53898 - Next Meeting of the North American Numbering Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-30

    ... North American Portability Management LLC (NAPM LLC). 9. Report of the LNPA Selection Working Group (SWG). 10. Report of the Local Number Portability Administration (LNPA) Working Group. 11. Status of the... Deborah.Blue@fcc.gov . The fax number is: (202) 418-1413. The TTY number is: (202) 418-0484....

  9. 75 FR 4557 - Next Meeting of the North American Numbering Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-28

    ... Block Pooling Administrator (PA). 7. Report of the Local Number Portability Administration (LNPA) Working Group. 8. Report of North American Portability Management LLC (NAPM LLC). 9. Telcordia Dispute... (202) 418-1466 or Deborah.Blue@fcc.gov . The fax number is: (202) 418-1413. The TTY number is:...

  10. 78 FR 8530 - Next Meeting of the North American Numbering Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-06

    .... Report of the LNPA Selection Working Group (SWG) 10. Report of the Local Number Portability... INFORMATION CONTACT: Carmell Weathers at (202) 418-2325 or Carmell.Weathers@fcc.gov . The fax number is: (202) 418-1413. The TTY number is: (202) 418-0484. SUPPLEMENTARY INFORMATION: This is a summary of...

  11. 76 FR 50425 - Service Rules and Policies for the Broadcasting Satellite Service (BSS)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-15

    ...-axis power flux density (pfd) coordination trigger for 17/24 GHz BSS space stations. We also require a...-0432 (tty). Synopsis 1. We adopt an off-axis power flux density (pfd) coordination trigger for 17/24... terrestrial services. 2. Off-Axis Power Flux Density Coordination Trigger. We adopt an off-axis pfd...

  12. 76 FR 71037 - Proposed National Toxicology Program (NTP) Review Process for the Report on Carcinogens: Request...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-16

    ... Federal Register (76 FR 67200) and is available on the NTP Web site ( http://ntp.niehs.nih.gov/go... on the NTP Web site ( http://ntp.niehs.nih.gov/go/rocprocess ) prior to the November 29, 2011... the NTP Web site ( http://ntp.niehs.nih.gov/go/rocprocess ). TTY users should contact the Federal...

  13. 14 CFR Appendix - Special Federal Aviation Regulation No. 109

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    .... Applicability. Contrary provisions of 14 CFR parts 21, 25, and 119 of this chapter notwithstanding, an applicant... of 14 CFR 91.533(b): (1) The number of flight attendants required by § 91.533(a)(1) and (2) of this... similar seat installation. TTI data must be acquired with a Side Impact Dummy (SID), as defined by 49...

  14. 14 CFR Appendix - Special Federal Aviation Regulation No. 109

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    .... Applicability. Contrary provisions of 14 CFR parts 21, 25, and 119 of this chapter notwithstanding, an applicant... of 14 CFR 91.533(b): (1) The number of flight attendants required by § 91.533(a)(1) and (2) of this... similar seat installation. TTI data must be acquired with a Side Impact Dummy (SID), as defined by 49...

  15. 14 CFR Appendix - Special Federal Aviation Regulation No. 109

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    .... Applicability. Contrary provisions of 14 CFR parts 21, 25, and 119 of this chapter notwithstanding, an applicant... of 14 CFR 91.533(b): (1) The number of flight attendants required by § 91.533(a)(1) and (2) of this... similar seat installation. TTI data must be acquired with a Side Impact Dummy (SID), as defined by 49...

  16. ALT telomeres get together with nuclear receptors.

    PubMed

    Aeby, Eric; Lingner, Joachim

    2015-02-26

    Nuclear receptors bind chromosome ends in "alternative lengthening of telomeres" (ALT) cancer cells that maintain their ends by homologous recombination instead of telomerase. Marzec et al. now demonstrate that, in ALT cells, nuclear receptors not only trigger distal chromatin associations to mediate telomere-telomere recombination events, but also drive chromosome-internal targeted telomere insertions (TTI). PMID:25723159

  17. 47 CFR 7.20 - Review and disposition of informal complaints.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    .... 7.20 Section 7.20 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL ACCESS TO VOICEMAIL AND INTERACTIVE MENU SERVICES AND EQUIPMENT BY PEOPLE WITH DISABILITIES Enforcement § 7.20 Review and... requested by the complainant, (e.g., letter, facsimile transmission, telephone (voice/TRS/TTY), Internet...

  18. 47 CFR 7.20 - Review and disposition of informal complaints.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    .... 7.20 Section 7.20 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL ACCESS TO VOICEMAIL AND INTERACTIVE MENU SERVICES AND EQUIPMENT BY PEOPLE WITH DISABILITIES Enforcement § 7.20 Review and... requested by the complainant, (e.g., letter, facsimile transmission, telephone (voice/TRS/TTY), Internet...

  19. 76 FR 65112 - James Zadroga 9/11 Health and Compensation Act of 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-20

    ... that appeared in the Federal Register of August 31, 2011 (76 FR 54112). That document issued...., Washington, DC 20530, telephone 855-885-1555 (TTY 855-885-1558). SUPPLEMENTARY INFORMATION: In FR Doc. 2011..., employment, investment, productivity, innovation, or on the ability of United States-based companies...

  20. SOCIO-EMOTIONAL AND CHARACTER DEVELOPMENT

    PubMed Central

    Snyder, Frank J.

    2015-01-01

    More and more researchers are studying socio-emotional and character development (SECD). The rise and progress in SECD research is encouraging, but there is a critical issue with such a multidisciplinary and fast-developing field: SECD research and evaluation can be more consistent to prevent heterogeneity in definitions and disparate theoretical, measurement, and program models. After summarizing SECD-related literature, I recommend the theory of triadic influence (TTI) as a force to generate consistency and a resource to assist in guiding the design and evaluation of SECD-related programs. The theory fills a gulf in the literature that seeks an ecological theory aligned with SECD-related programs and etiology. The recommendation of the TTI stems from 3 main advantages: (1) The TTI integrates a full range of risk and protective factors in a detailed mediation and moderation framework; (2) it takes a comprehensive view of all the stakeholders in the educational system (i.e., youth, schools, families, and communities); (3) and its utility has been substantiated by empirical evidence from a variety of fields. I discuss applications of the TTI in SECD-related work and suggest improvements for etiology research and the design and evaluation of SECD programs. PMID:26478721

  1. 77 FR 24190 - East Cheyenne Gas Storage, LLC; Notice of Amendment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-23

    ... April 6, 2012, East Cheyenne Gas Storage, LLC (East Cheyenne), 10901 W. Toller Drive, Suite 200... (toll free). For TTY, call (202) 502-8659. Comment Date: May 4, 2012. Dated: April 13, 2012. Kimberly D... this application may be directed to William A. Lang, President, East Cheyenne Gas Storage, LLC,...

  2. 77 FR 15369 - Mobility Fund Phase I Auction GIS Data of Potentially Eligible Census Blocks

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-15

    ... COMMISSION Mobility Fund Phase I Auction GIS Data of Potentially Eligible Census Blocks AGENCY: Federal... information system (GIS) data for the census blocks potentially eligible for Mobility Fund Phase I support to...-0432 (TTY). SUPPLEMENTARY INFORMATION: This is a summary of the Mobility Fund Phase I Auction GIS...

  3. 76 FR 19357 - FCC To Hold Open Commission Meeting, Thursday, April 7, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-07

    ... Networks of Damage or Failure of Network Equipment or Severe Overload (PS Docket No. 10-92); Independent... can contact you if we need more information. Last minute requests will be accepted, but may be... 202-418-0530 (voice), 202-418-0432 (tty). Additional information concerning this meeting may...

  4. 75 FR 21603 - Information Collection; Submission for OMB Review, Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... telecommunications device for the deaf (TTY-TDD) may call (202) 606-3472 between 8:30 a.m. and 5 p.m. Eastern time... the National Council on Aging (NCOA) to adapt its SMART (Strategic Metrics and Results...

  5. 75 FR 1359 - Information Collection; Submission for OMB Review, Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-11

    ... Longitudinal Evaluation of AmeriCorps Members: Respondent Tracking to the Office of Management and Budget (OMB... who use a telecommunications device for the deaf (TTY-TDD) may call (202) 606-3472 between 8:30 a.m... Tracking. The proposed locating effort will be completed by longitudinal sample members only,...

  6. Analyzing for Individual Differences in Evaluating Compensatory Education Programs. Occasional Paper No. 27.

    ERIC Educational Resources Information Center

    Krus, Patricia H.

    Trait-Treatment Interaction (TTI), a research method for observing experimental effects of treatments on subjects of different aptitudes and learning characteristics, is suggested as an effective evaluation tool to provide evaluators and educators in compensatory education programs with information about which program is best for different kinds…

  7. 75 FR 61998 - Programs for Specific Positions and Examinations (Miscellaneous)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-07

    ... INFORMATION CONTACT: Ms. Linda Watson by telephone at (202) 606-0830; by fax at (202) 606-2329; by TTY at (202) 418-3134; or by e- mail at linda.watson@opm.gov . SUPPLEMENTARY INFORMATION: On March 20, 2007, OPM published a final rule at 72 FR 12947, to revise the Administrative Law Judge Program. These...

  8. 76 FR 16399 - Combined Notice of Filings #2

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the... free). For TTY, call (202) 502-8659. Dated: March 14, 2011. Nathaniel J. Davis, Sr., Deputy...

  9. 78 FR 52781 - 30-Day Notice of Proposed Information Collection: Disclosure of Adjustable Rate Mortgages (ARMs...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-26

    ... URBAN DEVELOPMENT 30-Day Notice of Proposed Information Collection: Disclosure of Adjustable Rate... or speech impairments may access this number through TTY by calling the toll-free Federal Relay... Collection: Disclosure of Adjustable Rate Mortgages (ARMs) Rates. OMB Approval Number: 2502-0322. Type...

  10. 78 FR 36231 - 60-Day Notice of Proposed Information Collection: FHA-Disclosure of Adjustable Rate Mortgages...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-17

    ... URBAN DEVELOPMENT 60-Day Notice of Proposed Information Collection: FHA--Disclosure of Adjustable Rate... the proposed forms or other available information. Persons with hearing or speech impairments may... speech impairments may access this number through TTY by calling the toll-free Federal Relay Service...

  11. 75 FR 39681 - Tennessee Pipeline Company; Notice of Request Under Blanket Authorization

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-12

    ... Energy Regulatory Commission Tennessee Pipeline Company; Notice of Request Under Blanket Authorization July 1, 2010. Take notice that on June 18, 2010, Tennessee Pipeline Company (Tennessee), 1001 Louisiana... TTY, (202) 502-8659. Specifically, Tennessee proposes to abandon an inactive offshore supply...

  12. 75 FR 5317 - Tennessee Gas Pipeline Company; Notice of Request Under Blanket Authorization

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-02

    ... Federal Energy Regulatory Commission Tennessee Gas Pipeline Company; Notice of Request Under Blanket Authorization January 26, 2010. Take notice that on January 25, 2010, Tennessee Gas Pipeline Company (Tennessee... TTY, (202) 502-8659. Specifically, Tennessee proposes to abandon in place Line 509A-3600...

  13. A prospective, randomised, clinical study to compare the use of McGrath®, Truview® and Macintosh laryngoscopes for endotracheal intubation by novice and experienced Anaesthesiologists

    PubMed Central

    Bakshi, Sumitra G; Vanjari, Vinayak S; Divatia, Jigeeshu V

    2015-01-01

    Background and Aims: Video laryngoscopy has been recommended as an alternative during difficult conventional direct laryngoscopy using the Macintosh blade (MAC). However, successful visualisation of the larynx and tracheal intubation using some of the indirect laryngoscopes or video laryngoscopes (VL) requires hand-eye coordination. We conducted this study to determine whether non-channel VLs are easy to use for novices and whether there is any association between expertise with MAC and ease of tracheal intubation with VLs. Methods: Anaesthesiologists participating in the study were divided into three groups: Group novice to intubation (NTI), Group novice to videoscope (NVL)- experienced with MAC, novice to VLs and Group expert (EXP) experienced in all. Group NTI, NVL received prior mannequin training. VLs- Truview® and McGrath series 5 (MGR) were compared with MAC. One hundred and twenty six adult patients with normal airway were randomised to both, the intubating anaesthesiologist and laryngoscope. The time taken to intubate (TTI) and participants’ rating of the ease of use was recorded on a scale of 1–10 (10-most difficult). Results: In Group NTI, there was no difference in mean TTI with the three scopes (P = 0.938). In Group NVL, TTI was longer with the VLs than MAC (P < 0.001). In Group EXP, TTI with VL took 20 s more (P < 0.001). There was significant difference in participants’ rating of ease of use of laryngoscope in Group NVL (P = 0.001) but not in the NTI (P = 0.205), EXP (P = 0.529) groups. A high failure was seen with MGR in Group NTI and NVL. Conclusion: In Group NTI, TTI and the ease of use were similar for all scopes. Expertise with standard direct laryngoscopy does not translate to expertise with VLs. Separate training and experience with VLs is required. PMID:26257415

  14. Use of Radiolabelled Thymidine and Leucine To Estimate Bacterial Production in Soils from Continental Antarctica

    PubMed Central

    Tibbles, B. J.; Harris, J. M.

    1996-01-01

    Tritiated thymidine incorporation (TTI) into DNA was used to examine bacterial production in two soil types from the Robertskollen group of nunataks in northwestern Dronning Maud Land, providing the first estimates of bacterial production in soil habitats on the Antarctic continent. Although estimates of bacterial productivity in soils near to bird nests (344 (plusmn) 422 ng of C g [dry weight](sup-1) h(sup-1)) were higher than those for soils from beneath mosses (175 (plusmn) 90 ng of C g [dry weight](sup-1) h(sup-1); measured by TTI at 10(deg)C), these differences were not significant because of patchiness of bacterial activity (P > 0.05). TTI- and [(sup14)C]leucine ([(sup14)C]Leu)-derived estimates of bacterial production were similar when incubations of 3 h were used, although incubations as short as 1 h were sufficient for measurable uptake of radiolabel. Dual-label incorporation of [(sup3)H]thymidine ([(sup3)H]TdR) into DNA and [(sup14)C]Leu into protein indicated that TTI did not reflect bacterial production of in situ assemblages when incubations were longer than 3 h. Isotope dilution analysis indicated that dilution of the specific activity of exogenously supplied [(sup3)H]TdR by de novo synthesis of TdR precursor could be limited by additions of [(sup3)H]TdR at a concentration of 1 nmol per ca. 115 mg of soil. TTI exhibited a psychrotrophic response to variation in temperature, with a temperature optimum of ca. 15(deg)C and a Q(inf10) value for 0 to 10(deg)C of 2.41. PMID:16535246

  15. Development, Testing, and Application of a Coupled Hydrodynamic Surface-Water/Groundwater Model (FTLOADDS) with Heat and Salinity Transport in the Ten Thousand Islands/Picayune Strand Restoration Project Area, Florida

    USGS Publications Warehouse

    Swain, Eric D.; Decker, Jeremy D.

    2009-01-01

    A numerical model application was developed for the coastal area inland of the Ten Thousand Islands (TTI) in southwestern Florida using the Flow and Transport in a Linked Overland/Aquifer Density-Dependent System (FTLOADDS) model. This model couples a two-dimensional dynamic surface-water model with a three-dimensional groundwater model, and has been applied to several locations in southern Florida. The model application solves equations for salt transport in groundwater and surface water, and also simulates surface-water temperature using a newly enhanced heat transport algorithm. One of the purposes of the TTI application is to simulate hydrologic factors that relate to habitat suitability for the West Indian Manatee. Both salinity and temperature have been shown to be important factors for manatee survival. The inland area of the TTI domain is the location of the Picayune Strand Restoration Project, which is designed to restore predevelopment hydrology through the filling and plugging of canals, construction of spreader channels, and the construction of levees and pump stations. The effects of these changes are simulated to determine their effects on manatee habitat. The TTI application utilizes a large amount of input data for both surface-water and groundwater flow simulations. These data include topography, frictional resistance, atmospheric data including rainfall and air temperature, aquifer properties, and boundary conditions for tidal levels, inflows, groundwater heads, and salinities. Calibration was achieved by adjusting the parameters having the largest uncertainty: surface-water inflows, the surface-water transport dispersion coefficient, and evapotranspiration. A sensitivity analysis did not indicate that further parameter changes would yield an overall improvement in simulation results. The agreement between field data from GPS-tracked manatees and TTI application results demonstrates that the model can predict the salinity and temperature

  16. Formation resistivity as an indicator of the onset of oil generation in the Woodford Shale, Anadarko Basin, Oklahoma

    USGS Publications Warehouse

    Schmoker, James W.; Hester, Timothy C.

    1989-01-01

    The Upper Devonian and Lower Mississippian Woodford Shale is a black, organic-rich shale that is a major hydrocarbon source rock in the Anadarko basin. With the onset of oil generation, nonconductive hydrocarbons begin to replace conductive pore water in the Woodford, and formation resistivity increases. Crossplots of formation resistivity versus either vitrinite reflectance (RO) or Lopatin's time-temperature index of thermal maturity (TTI) define two data populations that represent immature shales and shales that have generated oil. The midpoint of the resistivity zone marking the transition between immature and mature shales is -35 ohm-m. The onset of appreciable oil generation in the Woodford Shale of the study area occurs at maturity levels of RO near 0.57% and of TTI between 33 and 48.

  17. Use of smart photochromic indicator for dynamic monitoring of the shelf life of chilled chicken based products.

    PubMed

    Brizio, Ana Paula Dutra Resem; Prentice, Carlos

    2014-03-01

    This study evaluated the applicability of a photochromic time temperature indicator (TTI) to monitor the time-temperature history and shelf life of chilled boneless chicken breast. The results showed that the smart indicator showed good reproducibility during the discoloring process in all the conditions investigated. The response was not only visibly interpretable but also well adaptable to measurement using appropriate equipment. For an activation configuration of 4 s of ultraviolet light (UV) per label, the TTI's rate of discoloration was similar to the quality loss of the meat samples analyzed. Thus, the photochromic label (4 s UV/label) attached to the samples set out to be a dynamic shelf-life label, assuring consumers the final point of quality of chilled boneless chicken breast in an easy and precise form, providing a reliable tool to monitor the supply chain of this product. PMID:24334043

  18. Nuclear-receptor-mediated telomere insertion leads to genome instability in ALT cancers.

    PubMed

    Marzec, Paulina; Armenise, Claudia; Pérot, Gaëlle; Roumelioti, Fani-Marlen; Basyuk, Eugenia; Gagos, Sarantis; Chibon, Frédéric; Déjardin, Jérôme

    2015-02-26

    The breakage-fusion-bridge cycle is a classical mechanism of telomere-driven genome instability in which dysfunctional telomeres are fused to other chromosomal extremities, creating dicentric chromosomes that eventually break at mitosis. Here, we uncover a distinct pathway of telomere-driven genome instability, specifically occurring in cells that maintain telomeres with the alternative lengthening of telomeres mechanism. We show that, in these cells, telomeric DNA is added to multiple discrete sites throughout the genome, corresponding to regions regulated by NR2C/F transcription factors. These proteins drive local telomere DNA addition by recruiting telomeric chromatin. This mechanism, which we name targeted telomere insertion (TTI), generates potential common fragile sites that destabilize the genome. We propose that TTI driven by NR2C/F proteins contributes to the formation of complex karyotypes in ALT tumors. PMID:25723166

  19. 78 FR 32381 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-30

    ...; ER10-3071-001; ER11-4266- 005; ER10-3257-001. Applicants: CalPeak Power--Border LLC, CalPeak Power--Enterprise LLC, CalPeak Power--Panoche LLC, CalPeak Power--Vaca Dixon LLC, CalPeak Power LLC, Chambers.../efiling/filing-req.pdf . For other information, call (866) 208-3676 (toll free). For TTY, call (202)...

  20. 78 FR 35625 - Sabine Pass Liquefaction Expansion, LLC; Sabine Pass Liquefaction, LLC; Sabine Pass LNG, L.P...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-13

    ...-000, CP04-39-000, CP04- 40-000, CP05-396-000, CP04-47-001, CP-05-396-001, CP11-72-000, and CP13-02-000... toll free at (866) 208-3676, or for TTY, contact (202) 502-8659. The eLibrary link also provides access.... In addition, the Commission now offers a free service called eSubscription which allows you to...

  1. Malignant pleural effusions and the role of talc poudrage and talc slurry: a systematic review and meta-analysis

    PubMed Central

    Mummadi, Srinivas; Kumbam, Anusha; Hahn, Peter Y.

    2015-01-01

    Background: Malignant Pleural Effusion (MPE) is common with advanced malignancy. Palliative care with minimal adverse events is the cornerstone of management. Although talc pleurodesis plays an important role in treatment, the best modality of talc application remains controversial.   Objective: To compare rates of successful pleurodesis, rates of respiratory and non-respiratory complications between thoracoscopic talc insufflation/poudrage (TTI) and talc slurry (TS).  Data sources and study selection: MEDLINE (PubMed, OVID),  EBM Reviews (Cochrane database of Systematic Reviews, ACP Journal Club, DARE, Cochrane Central Register of Controlled Trials, Cochrane Methodology Register, Health Technology Assessment and NHS Economic Evaluation Database), EMBASE and Scopus. Randomized controlled trials published between 01/01/1980 - 10/1/2014 and comparing the two strategies were selected.  Results: Twenty-eight potential studies were identified of which 24 studies were further excluded, leaving four studies. No statistically significant difference in the probability of successful pleurodesis was observed between TS and TTI groups (RR 1.06; 95 % CI 0.99-1.14; Q statistic, 4.84). There was a higher risk of post procedural respiratory complications in the TTI group compared to the TS group (RR 1.91, 95% CI= 1.24-2.93, Q statistic 3.15). No statistically significant difference in the incidence of non-respiratory complications between the TTI group and the TS group was observed (RR 0.88, 95% CI= 0.72-1.07, Q statistic 4.61). Conclusions: There is no difference in success rates of pleurodesis based on patient centered outcomes between talc poudrage and talc slurry treatments.  Respiratory complications are more common with talc poudrage via thoracoscopy. PMID:25878773

  2. 77 FR 27253 - Proposed Collection, Laura Bush 21st Century Librarian Grant Program Evaluation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-09

    ...The Institute of Museum and Library Services announces the following information collection has been submitted to the Office of Management and Budget for review and approval in accordance with the Paperwork Reduction Act (44 U.S.C. Chapter 35). Individuals who use a telecommunications device for the deaf (TTY/TDD) may call 202-653-4614. This review helps to ensure that requested data can be......

  3. Is Having Sex with Other Men a Risk Factor for Transfusion-Transmissible Infections in Male Blood Donors in Western Countries? A Systematic Review

    PubMed Central

    De Buck, Emmy; Dieltjens, Tessa; Compernolle, Veerle; Vandekerckhove, Philippe

    2015-01-01

    Background Although increased prevalence of transfusion transmissible infections (TTI) among “men who have sex with men” (MSM) has been well documented, the exclusion of MSM as blood donors is contested. The aim of this systematic review is to find studies that describe the risk of TTI in MSM blood donors. Methods We searched MEDLINE, Embase, The Cochrane Central Register of Controlled Trials, Cinahl, and Web of Science, and used GRADE for determining evidence quality. We included studies comparing MSM and non-MSM blood donors (or people eligible to give blood), living in areas most relevant for our Blood Service. Results Out of 18 987 articles, 14 observational studies were included. Two studies directly compared MSM with non-MSM donors showing that MSM donors have a statistically significant higher risk of HIV-1 infections. In one of these studies it was shown that this was related to recent (< 12 months) MSM contact. In two additional studies no evidence was shown in favour of a certain deferral period for MSM. Ten studies, applying permanent deferral for MSM, compared infected versus non-infected donors. One study found that MSM is a statistically significant risk factor for HIV-1 infection in blood donors. For other TTI such as HBV or HCV, an increased risk of infection could not be demonstrated, because the precision of the results was affected by the low numbers of donors with MSM as risk factor, or because of risk of bias in the included studies. All studies included low level evidence, because of risk of bias and imprecision of the results. Conclusions High-quality studies investigating the risk of TTI in MSM who donate blood are scarce. The available evidence suggests a link between MSM blood donors and HIV-1 infection, but is too limited to be able to unambiguously/clearly recommend a certain deferral policy. PMID:25875812

  4. Use of global sensitivity analysis in quantitative microbial risk assessment: application to the evaluation of a biological time temperature integrator as a quality and safety indicator for cold smoked salmon.

    PubMed

    Ellouze, M; Gauchi, J-P; Augustin, J-C

    2011-06-01

    The aim of this study was to apply a global sensitivity analysis (SA) method in model simplification and to evaluate (eO)®, a biological Time Temperature Integrator (TTI) as a quality and safety indicator for cold smoked salmon (CSS). Models were thus developed to predict the evolutions of Listeria monocytogenes and the indigenous food flora in CSS and to predict TTIs endpoint. A global SA was then applied on the three models to identify the less important factors and simplify the models accordingly. Results showed that the subset of the most important factors of the three models was mainly composed of the durations and temperatures of two chill chain links, out of the control of the manufacturers: the domestic refrigerator and the retail/cabinet links. Then, the simplified versions of the three models were run with 10(4) time temperature profiles representing the variability associated to the microbial behavior, to the TTIs evolution and to the French chill chain characteristics. The results were used to assess the distributions of the microbial contaminations obtained at the TTI endpoint and at the end of the simulated profiles and proved that, in the case of poor storage conditions, the TTI use could reduce the number of unacceptable foods by 50%. PMID:21511136

  5. Hepatitis B, Hepatitis C, Human immunodeficiency virus and syphilis frequency among blood donors: A single center study.

    PubMed

    Yildiz, Sule Menziletoglu; Candevir, Aslihan; Kibar, Filiz; Karaboga, Gulser; Turhan, Ferda Tekin; Kis, Cem; Dincer, Suleyman; Guvenc, Birol

    2015-12-01

    We aimed to provide updated results for seroprevalence of hepatitis B, hepatitis C viruses while presenting first data for human immunodeficiency virus and syphilis seropositivity amongst blood donors in Adana, Turkey. Screening and confirmatory test results of 62,461 donors were evaluated. HBsAg, anti-HCV, anti-HIV1/2 and syphilis seropositivity was 1.92%, 0.48%, 0.20%, 0.18% respectively, based on screening tests, and 1.66%, 0.05%, 0.003%, 0.10% respectively, according to confirmatory tests. Transfusion-transmitted infections (TTI) was more prevalent in low-educated donors. HBsAg and syphilis seropositivity rates were higher in married subjects. We found that the prevalence of HBV and HCV was significantly decreased in the last two decades in Adana. Importantly, this study provides first data in HIV and syphilis seropositivity rates among blood donors in our region and both HIV and syphilis seroprevalences were found to be low compared to many regions of Turkey. However, considering the fact that increasing number of immigrants may change prevalences and trends of TTI both in Adana and in Turkey, strict monitorization and yearly reporting of TTI rates seem necessary to be able to take proactive measures. PMID:26070837

  6. The Illicit Use of Prescription Stimulants on College Campuses: A Theory-Guided Systematic Review.

    PubMed

    Bavarian, Niloofar; Flay, Brian R; Ketcham, Patricia L; Smit, Ellen

    2015-12-01

    The illicit use of prescription stimulants (IUPS) is a substance use behavior that remains prevalent on college campuses. As theory can guide research and practice, we provide a systematic review of the college-based IUPS epidemiological literature guided by one ecological framework, the theory of triadic influence (TTI). We aim to assess prevalence, elucidate the behavior's multietiological nature, and discuss prevention implications. Peer-reviewed studies were located through key phrase searches (prescription stimulant misuse and college, "prescription stimulant misuse" and "college," illicit use of prescription stimulants in college, and nonmedical prescription stimulant use in college students) in electronic databases (PubMed, PubMed Central, and EBSCO Host) for the period 2000 to 2013. Studies meeting inclusion criteria had their references reviewed for additional eligible literature. Statistically significant correlates of IUPS in the 62 retrieved studies were organized using the three streams of influence and four levels of causation specified in the TTI. Results show that the prevalence of IUPS varies across campuses. Additionally, findings suggest the behavior is multifaceted, as correlates were observed within each stream of influence and level of causation specified by the TTI. We conclude that IUPS is prevalent in, but varies across, colleges and is influenced by intrapersonal and broader social and societal factors. We discuss implications for prevention and directions for future research. PMID:26032000

  7. Non-electrical-power temperature-time integrating sensor for RFID based on microfluidics

    NASA Astrophysics Data System (ADS)

    Schneider, Mike; Hoffmann, Martin

    2011-06-01

    The integration of RFID tags into packages offers the opportunity to combine logistic advantages of the technology with monitoring different parameters from inside the package at the same time. An essential demand for enhanced product safety especially in pharmacy or food industry is the monitoring of the time-temperature-integral. Thus, completely passive time-temperature-integrators (TTI) requiring no battery, microprocessor nor data logging devices are developed. TTI representing the sterilization process inside an autoclave system is a demanding challenge: a temperature of at least 120 °C have to be maintained over 45 minutes to assure that no unwanted organism remains. Due to increased temperature, the viscosity of a fluid changes and thus the speed of the fluid inside the channel increases. The filled length of the channel represents the time temperature integral affecting the system. Measurements as well as simulations allow drawing conclusions about the influence of the geometrical parameters of the system and provide the possibility of adaptation. Thus a completely passive sensor element for monitoring an integral parameter with waiving of external electrical power supply and data processing technology is demonstrated. Furthermore, it is shown how to adjust the specific TTI parameters of the sensor to different applications and needs by modifying the geometrical parameters of the system.

  8. New stimulation pattern design to improve P300-based matrix speller performance at high flash rate

    NASA Astrophysics Data System (ADS)

    Polprasert, Chantri; Kukieattikool, Pratana; Demeechai, Tanee; Ritcey, James A.; Siwamogsatham, Siwaruk

    2013-06-01

    Objective. We propose a new stimulation pattern design for the P300-based matrix speller aimed at increasing the minimum target-to-target interval (TTI). Approach. Inspired by the simplicity and strong performance of the conventional row-column (RC) stimulation, the proposed stimulation is obtained by modifying the RC stimulation through alternating row and column flashes which are selected based on the proposed design rules. The second flash of the double-flash components is then delayed for a number of flashing instants to increase the minimum TTI. The trade-off inherited in this approach is the reduced randomness within the stimulation pattern. Main results. We test the proposed stimulation pattern and compare its performance in terms of selection accuracy, raw and practical bit rates with the conventional RC flashing paradigm over several flash rates. By increasing the minimum TTI within the stimulation sequence, the proposed stimulation has more event-related potentials that can be identified compared to that of the conventional RC stimulations, as the flash rate increases. This leads to significant performance improvement in terms of the letter selection accuracy, the raw and practical bit rates over the conventional RC stimulation. Significance. These studies demonstrate that significant performance improvement over the RC stimulation is obtained without additional testing or training samples to compensate for low P300 amplitude at high flash rate. We show that our proposed stimulation is more robust to reduced signal strength due to the increased flash rate than the RC stimulation.

  9. [Circadian variation in the latency of auditory brainstem response].

    PubMed

    Murakami, S; Sotsu, M; Nakamura, N

    1992-07-01

    The auditory brainstem response (ABR) has been found to reflect many pathological conditions within the auditory system and brainstem. And now, many neurosurgeons are using it to monitor the integrity of the auditory pathway during neurosurgical procedures. It is said that ABR shows little variation from person to person or laboratory to laboratory, nor is it easily affected by anesthesia, level of consciousness, fluctuation of blood pressure or hypoxemia. On the other hand, previous studies have shown that component waves of the ABR increase in latency and decrease in amplitude with lowered temperature. We reported here that naturally occurring circadian variations in body temperature were correlated with similar changes in the latency of the ABR. Tympanic temperature (Tty), deep forehead temperature (Thd) and ABR were recorded every 3 hours during a 24-hour period for a total of 8 recording sessions from each of 6 healthy persons (2 males and 4 females, mean age 24.3 years). The subjects were free to come and go during the day but slept overnight in the laboratory. All subjects had circadian variations in each temperature on the order of one degree. Thd had a tendency to fluctuate and its range of difference from Tty was -0.5-0.4 degree C. There was a more significant negative correlation between the latency of the ABR and Tty than that of Thd. It has become apparent that ABR latency is affected by small temperature changes such as circadian variation. The rate of a latency change in the ABR was 0.15msec per degree (C).(ABSTRACT TRUNCATED AT 250 WORDS) PMID:1329888

  10. Human skeletal muscle metabolic economy in vivo: effects of contraction intensity, age, and mobility impairment

    PubMed Central

    Christie, Anita D.; Tonson, Anne; Larsen, Ryan G.; DeBlois, Jacob P.

    2014-01-01

    We tested the hypothesis that older muscle has greater metabolic economy (ME) in vivo than young, in a manner dependent, in part, on contraction intensity. Twenty young (Y; 24 ± 1 yr, 10 women), 18 older healthy (O; 73 ± 2, 9 women) and 9 older individuals with mild-to-moderate mobility impairment (OI; 74 ± 1, 7 women) received stimulated twitches (2 Hz, 3 min) and performed nonfatiguing voluntary (20, 50, and 100% maximal; 12 s each) isometric dorsiflexion contractions. Torque-time integrals (TTI; Nm·s) were calculated and expressed relative to maximal fat-free muscle cross-sectional area (cm2), and torque variability during voluntary contractions was calculated as the coefficient of variation. Total ATP cost of contraction (mM) was determined from flux through the creatine kinase reaction, nonoxidative glycolysis and oxidative phosphorylation, and used to calculate ME (Nm·s·cm−2·mM ATP−1). While twitch torque relaxation was slower in O and OI compared with Y (P ≤ 0.001), twitch TTI, ATP cost, and economy were similar across groups (P ≥ 0.15), indicating comparable intrinsic muscle economy during electrically induced isometric contractions in vivo. During voluntary contractions, normalized TTI and total ATP cost did not differ significantly across groups (P ≥ 0.20). However, ME was lower in OI than Y or O at 20% and 50% MVC (P ≤ 0.02), and torque variability was greater in OI than Y or O at 20% MVC (P ≤ 0.05). These results refute the hypothesis of greater muscle ME in old age, and provide support for lower ME in impaired older adults as a potential mechanism or consequence of age-related reductions in functional mobility. PMID:25163917

  11. Engineering and management experience at Texas A&M Transportation Institute

    NASA Astrophysics Data System (ADS)

    Chowdhury, Arif Tahjibul

    This manuscript presents the author's engineering and management experience during his internship in the Materials and Pavements (M&P) Division at the Texas A&M Transportation Institute (TTI), and is a record of study for the Doctor of Engineering at Texas A&M University. Through this internship, he met his established internship objectives of gaining technical knowledge as well as knowledge and skills in project management, organizational communication, and quality management of pavement condition data, and of attaining professional development. In meeting these objectives, the author describes the history, mission, and organizational structure of his workplace. He also presents his experience of developing and delivering a two-week training course on pavement design and construction in Kosovo. Participating in a number of professional development training courses and other activities prepared him for working as an engineering manager. These activities include Delta-T leadership training, an instructor development course, a time management and organizational skills course, and the M&P Division lecture series. Leadership and skills learned through the Delta-T program were beneficial for the employee as well as the employer. For the class project, the author and his teammates performed a study dealing with improving TTI's deliverables. The Delta-T team composed a report summarizing their efforts of examining the current state of TTI's project deliverables, the deliverables' shortcomings, and potential enhancements to expand the deliverables' appeal to additional types of potential users outside the traditional research community. The team also developed a prototype web-based model of deliverables and presented some implementation recommendations. Participating in the Texas Department of Transportation's (TxDOT's) pavement surface distress data collection program enabled the author to become familiar with pavement distress data quality management and thus attain the

  12. [Brain temperature in patients with central nervous system lesions].

    PubMed

    Mariak, Z; Lysoń, T; Piekarski, P; Lewko, J; Jadeszko, M; Szydlik, P

    2000-01-01

    The knowledge of human brain temperature is still very limited. In this report we investigated the relationship between brain and trunk temperature in neurosurgical patients during normothermia and fever. Another problem addressed was that of possible gradients of temperature within the brain. We carried out direct recordings of temperature in 63 operated, neurosurgical patients with a variety of intracranial pathologies. Flexible, teflon-coated thermocouples were placed intracranially during neurosurgical procedures. Oesophageal, rectal and tympanic temperatures were also monitored. An error of up to 1.3 degrees C is to be expected in single cases if brain temperature is deduced from the rectal or oesophageal temperature. Mean differences between brain temperature and core body temperature measured in the rectum or in the oesophagus, were between 0 to 0.3 degree C. Tympanic temperature (Tty) improved the approximation of brain temperature (Tbr) to within the mean difference between Tbr-Tty close to 0 degree C. Nevertheless Tty also differed from Tbr by as much as 1 degree C in single cases. Brain temperature was the highest body temperature measured, either in normothermia or in fever. Temperature gradients were proved to exist between the warmer brain interior and cooler surface, with maximal differences in temperature reaching 0.6 degree C. This temperature gradient tended to increase along with the rise in intracranial pressure and deterioration of the level of consciousness. Our results suggest that conclusions regarding brain temperature drawn on the basis of other core temperatures, may lead to significant errors, and intracranial temperature measurement is desirable in neurosurgical intensive care. Temperature gradients within the brain may exacerbate its biochemical injury during ischaemia and fever--a combination seen frequently in neurosurgical patients. This may be particularly so, since brain temperature in fever is the highest body temperature in a

  13. Timing of compaction and quartz cementation from integrated petrographic and burial-history analyses, Lower Cretaceous Fall River Formation, Wyoming and South Dakota

    SciTech Connect

    Dutton, S.P.

    1997-01-01

    Integrated petrographic and burial-history studies of Fall River sandstones from outcrop and the subsurface provide insight into the timing of compaction and quartz cementation, the two main porosity-reducing processes in quartzose sandstones. Petrographic study of 95 thin sections of Fall River fluvial valley-fill sandstones from outcrop, Donkey Creek field at 2 km burial depth, and Buck Draw field at 3.8 km indicates that reservoir quality differs significantly in these three areas. Fall River sandstones at the surface contain an average of 31% intergranular volume (IGV) and 2% quartz cement. In both Donkey Creek and Buck Draw fields, the sandstones average 22% IGV, but quartz-cement volume averages 8% in the shallower field and 12% in the deeper. Geometric mean permeability at the surface is 4,700 md, compared with 42 md at 2 km and 2 md at 3.8 km. Burial history of the Fall River sandstone differs greatly in the three areas. The outcropping sandstones were buried to 2 km and had reached 80 C by the end of the Cretaceous. They were then uplifted and have remained at near-surface temperatures since the Paleocene; the calculated time-temperature index (TTI) of these sandstones is 1. Fall River sandstones at Donkey Creek were also buried to 2 km and had reached 80 C by the end of the Cretaceous but remained at that depth during the Tertiary; TTI is 14. In Buck Draw field, Fall River sandstones were buried to 2.5 km during the Cretaceous and then continued to subside during the Tertiary, reaching depths of 4 km and temperatures of 140 C; TTI is 512.

  14. Organic Materials for Time-Temperature Integrator Devices.

    PubMed

    Cavallini, Massimiliano; Melucci, Manuela

    2015-08-12

    Time-temperature integrators (TTIs) are devices capable of recording the thermal history of a system. They have an enormous impact in the food and pharmaceutical industries. TTIs exploit several irreversible thermally activated transitions such as recrystallization, dewetting, smoothening, chemical decomposition, and polymorphic transitions, usually considered drawbacks for many technological applications. The aim of this article is to sensitize research groups working in organic synthesis and surface science toward TTI devices, enlarging the prospects of many new materials. We reviewed the principal applications highlighting the need and criticisms of TTIs, which offer a new opportunity for the development of many materials. PMID:26156082

  15. The Association of Tobacco Control Policies and the Risk of Acute Myocardial Infarction Using Hospital Admissions Data

    PubMed Central

    Jan, Carmen; Lee, Marcos; Roa, Reina; Herrera, Víctor; Politis, Michael; Motta, Jorge

    2014-01-01

    Objective To evaluate the association of a nationwide comprehensive smoking ban (CSB) and tobacco tax increase (TTI) on the risk of acute myocardial infarctions (AMI) in Panama for the period of 2006 – 2010 using hospital admissions data. Methods Data of AMI cases was gathered from public and private hospitals in the country for the period of January 1, 2006 to December 31, 2010. The number of AMI cases was calculated on a monthly basis. The risk of AMI was estimated for the pre-CSB period (January 2006 to April 2008) and was used as a reference point. Three post-intervention periods were examined: (1) post-CSB from May 2008 to April 2009 (12 months); (2) post-CSB from May 2009 to November 2009 (7 months); and (3) post-TTI from December 2009 to December 2010 (13 months). Relative risks (RR) of AMI were estimated for each post intervention periods by using a Poisson regression model. Mortality registries for the country attributed to myocardial infarction (MI) were obtained from January 2001 to December 2012. The annual percentage change (APC) of the number of deaths from MI was calculated using Joinpoint regression analysis. Results A total sample size of 2191 AMI cases was selected (monthly mean number of cases 36.52±8.24 SD). Using the pre-CSB as a reference point (RR = 1.00), the relative risk of AMI during the first CSB period, the second CSB period and post-TTI were 0.982, 1.049, and 0.985, respectively. The APC of deaths from MI from January 2001 to April 2008 was 0.5%. From January 2001 to June 2010 the APC trend was 0.47% and from July 2010 to December 2012 the APC was –0.3%. Conclusions The implementation of a CSB and TTI in Panama were associated with a decrease in tobacco consumption and a reduction of the RR of AMI. PMID:24520421

  16. TRANSF code user manual

    SciTech Connect

    Weaver, H.J.

    1981-11-01

    The TRANSF code is a semi-interactive FORTRAN IV program which is designed to calculate the model parameters of a (structural) system by performing a least square parameter fit to measured transfer function data. The code is available at LLNL on both the 7600 and the Cray machines. The transfer function data to be fit is read into the code via a disk file. The primary mode of output is FR80 graphics, although, it is also possible to have results written to either the TTY or to a disk file.

  17. Tracking magmatic processes through Zr/Hf ratios in rocks and Hf and Ti zoning in zircons: An example from the Spirit Mountain batholith, Nevada

    USGS Publications Warehouse

    Lowery, Claiborne L.E.; Miller, C.F.; Walker, B.A.; Wooden, J.L.; Mazdab, F.K.; Bea, F.

    2006-01-01

    Zirconium and Hf are nearly identical geochemically, and therefore most of the crust maintains near-chondritic Zr/Hf ratios of ???35-40. By contrast, many high-silica rhyolites and granites have anomalously low Zr/Hf (15-30). As zircon is the primary reservoir for both Zr and Hf and preferentially incorporates Zr, crystallization of zircon controls Zr/ Hf, imprinting low Zr/Hf on coexisting melt. Thus, low Zr/Hf is a unique fingerprint of effective magmatic fractionation in the crust. Age and compositional zonation in zircons themselves provide a record of the thermal and compositional histories of magmatic systems. High Hf (low Zr/ Hf) in zircon zones demonstrates growth from fractionated melt, and Ti provides an estimate of temperature of crystallization (TTiZ) (Watson and Harrison, 2005). Whole-rock Zr/Hf and zircon zonation in the Spirit Mountain batholith, Nevada, document repeated fractionation and thermal fluctuations. Ratios of Zr/Hf are ???30-40 for cumulates and 18-30 for high-SiO2 granites. In zircons, Hf (and U) are inversely correlated with Ti, and concentrations indicate large fluctuations in melt composition and TTiZ (>100??C) for individual zircons. Such variations are consistent with field relations and ion-probe zircon geochronology that indicate a >1 million year history of repeated replenishment, fractionation, and extraction of melt from crystal mush to form the low Zr/Hf high-SiO2 zone. ?? 2006 The Mineralogical Society.

  18. Passive thermal refugia provided warm water for Florida manatees during the severe winter of 2009-2010

    USGS Publications Warehouse

    Stith, B.M.; Slone, D.H.; de Wit, M.; Edwards, H.H.; Langtimm, C.A.; Swain, E.D.; Soderqvist, L.E.; Reid, J.P.

    2012-01-01

    Haloclines induced by freshwater inflow over tidal water have been identified as an important mechanism for maintaining warm water in passive thermal refugia (PTR) used by Florida manatees Trichechus manatus latirostris during winter in extreme southwestern Florida. Record-setting cold during winter 2009–2010 resulted in an unprecedented number of manatee deaths, adding to concerns that PTR may provide inadequate thermal protection during severe cold periods. Hydrological data from 2009–2010 indicate that 2 canal systems in the Ten Thousand Islands (TTI) region acted as PTR and maintained warm bottom-water temperatures, even during severe and prolonged cold periods. Aerial survey counts of live and dead manatees in TTI during the winter of 2009–2010 suggest that these PTR were effective at preventing mass mortality from hypothermia, in contrast to the nearby Everglades region, which lacks similar artificial PTR and showed high manatee carcass counts. Hydrological data from winter 2008–2009 confirmed earlier findings that without haloclines these artificial PTR may become ineffective as warm-water sites. Tidal pumping of groundwater appears to provide additional heat to bottom water during low tide cycles, but the associated thermal inversion is not observed unless salinity stratification is present. The finding that halocline-driven PTR can maintain warm water even under extreme winter conditions suggests that they may have significant potential as warm-water sites. However, availability and conflicting uses of freshwater and other management issues may make halocline-driven PTR unreliable or difficult to manage during winter.

  19. Factors controlling bacterial production in marine and freshwater sediments.

    PubMed

    Sander, B C; Kalff, J

    1993-09-01

    We collected benthic bacterial production data measured by (3)H thymidine incorporation (TTI) (25 studies), frequency of dividing cells (FDC) (3 studies), dark-C02 assimilation (1 study) and (3)H-adenine uptake (2 studies) from the literature, which included 18 marine, 6 river, and 2 lake studies. In all of the studies that used the TTI method, (3)H-DNA was isolated and incubations were carried out at in situ temperatures. Most of the researchers also determined (3)H-DNA extraction efficiencies and isotope dilution, thus interpretable estimates of bacterial production were used in the analysis. In marine sediments, bacterial production rates were linked to bacterial biomass, bacterial abundance, sediment organic matter, temperature, and sediment chlorophyll a, with these variables explaining between 40% and 68% of the variation in production rates. Simple relationships between production and bacterial biomass or bacterial abundance, or between production and sediment organic matter, were improved by also including temperature in the analysis of marine sediments. Sediment organic matter explained an appreciable fraction (58%) of the observed production in freshwater sediments. Temperature was the most powerful predictor of the observed variability in specific growth rates (r (2) = 0.48 and r (2) = 0.58) in marine and freshwater sediments, respectively. Thus, bacterial production and specific growth rates are most closely linked to substrate supply and temperature in marine and freshwater sediments. PMID:24190006

  20. Selected instability indices in Europe

    NASA Astrophysics Data System (ADS)

    Siedlecki, Mariusz

    2009-04-01

    A climatology of various parameters associated with severe weather and convective storms has been created for Europe that involves using radiosounding data collected at the University of Wyoming for the period from 1991 to 2005. The analysis is based on monthly means, frequency distributions of such parameters as convective available potential energy (CAPE), convective inhibition energy (CIN), KI - index, total totals index (TTI), and the severe weather threat index (SWEAT). Monthly average CAPE values exceeding 300 Jkg-1 are observed over the west Mediterranean Sea and the neighboring coastal countries. The similar seasonal cycle and spatial distributions exhibit CIN fields with summer monthly means above 100 Jkg-1 observed on the south part of the researched domain. The KI, TTI, and SWEAT indices, which assess both the lapse ratio between 850 and 500 hPa and low level humidity, show the privileged region (the Alpine area and the Carpathian Basin) with the highest instability conditions. Orography clearly plays an important role in this structure. Farther from this area, the monthly average decreases to the east, west, north, and south of the research domain. Ward’s procedure was applied to create objective regionalization according to instability conditions. This method tends to produce two regions with relatively different instability conditions and few subregions with similar conditions. The first region, covering the Alpine area, the west Mediterranean Sea, west Turkey and the southern Ukraine, is characterized by the highest instability. The rest of the investigated area is the second region with a more stable atmosphere.

  1. Seasonal acclimation in sudomotor function evaluated by QSART in healthy humans.

    PubMed

    Shin, Young Oh; Lee, Jeong-Beom; Kim, Jeong-Ho

    2016-09-01

    The quantitative sudomotor axon reflex testing (QSART) is a classic test of routine postganglionic sudomotor function. We investigated sudomotor function by QSART after summer (July 2012) and winter (January 2013) seasonal acclimation (SA) in the Republic of Korea. QSART with acetylcholine (ACh) iontophoresis were performed to determine directly activated (DIR) and axon reflex-mediated (AXR1, 2) sweating rate. Onset time of axon reflex, activated sweat gland density (ASGD), activated sweat gland output (ASGO), tympanic and skin temperatures (Tty, Tsk), basal metabolic rate (BMR), and evaporative loss volume changes were measured. Tympanic and mean body temperature (Tb; calculated from Tty, Tsk) were significantly lower after summer-SA than that of winter-SA. Sweat onset time was delayed during winter-SA compared to that after summer-SA. BMR, AXR(1), AXR(2), and DIR sweat rates, ASGD and ASGO, and evaporative loss volume were significantly diminished after winter-SA relative to after summer-SA. In conclusion, changes in sweating activity measured by QSART confirmed the involvement of the peripheral nervous system in variation of sudomotor activity in seasonal acclimation. PMID:27610036

  2. Validation and use of an enzymic time-temperature integrator to monitor thermal impacts inside a solid/liquid model food.

    PubMed

    Guiavarc'h, Yann P; Dintwa, Edward; Van Loey, Ann M; Zuber, François T; Hendrickx, Marc E

    2002-01-01

    Heat denaturation kinetics of Bacillus licheniformis alpha-amylase, equilibrated at 81% equilibrium relative humidity at 4 degrees C (BLA81), was studied with help of isothermal and nonisothermal conditions by monitoring the decrease in enthalpy associated with the heat denaturation of the enzyme. Due to its low water content, BLA81 denaturation could be studied in the range of 118-124 degrees C. Two batches of BLA81 were successfully validated under nonisothermal conditions allowing the determinations of process values (reference temperature of 121.1 degrees C) in the range of 1-15 min. In a second step, BLA81 was used as a time-temperature integrator (TTI) to investigate potential differences of process values received by freely moving spherical particles as compared to a centrally fixed particle (single-position impact) inside cans containing water as brine. Results showed that the process value received by freely moving particles can be from 5.6% (4 rpm) to 19.7% (8 rpm) smaller than the process value received by the centrally fixed sphere. This means that evaluating the process value by means of a particle fixed at the critical point in a package can lead to potentially overestimations of the actual process value with possible hazardous quality/safety implications. These results highlight the potentials of the TTI technology to monitor the safety of heat-processed agitated solid/liquid foodstuffs. PMID:12363362

  3. Left ventricular assist using a jet pump.

    PubMed

    Rhee, K; Blackshear, P L

    1990-01-01

    A simple, effective, cardiac assist device was developed using a jet pump, a device that performs pumping by energy transfer from a high speed jet to low speed surrounding fluids. This jet pump is inserted retrograde through the aorta and placed in the left ventricle transvalvularly. The jet of oxygenated venous blood entrains blood inside the left ventricle and pumps into the aorta through the aortic valve. Jet velocity is kept below the hemolytic threshold of 1000 cm/sec. The device was placed in a mock circulatory system that stimulates the left ventricle and vascular system by generating a pressure wave (120/75 mmHg) with a 4 L/min cardiac output (CO). A bypass loop (from the venous reservoir to aorta using a Biomedicus pump, Biomedicus Inc., Eden Prairie, MN) was set up, and the jet pump was installed. When the jet pump is turned on, bypass flow rate (BF) is 2.5 L/min, entrainment pumping 1.5 L/min, and peak ventricular pressure (VP) falls below aortic pressure (AP), while maintaining the mean AP. Time tension index (TTI) is decreased 31%. This result, when compared with simple bypass at differing BF, shows more than a 20% reduction in TTI. This simple jet pump provided significant unloading of the left ventricle and may be potentially useful as a left ventricular assist device. PMID:2252738

  4. Nucleic acid testing (NAT) in high prevalence-low resource settings.

    PubMed

    El Ekiaby, Magdy; Lelie, Nico; Allain, Jean-Pierre

    2010-01-01

    Blood screening by NAT for major transfusion transmitted viral infections (TTIs) was originally intended to complement serology for detection of infected donations. Reports from developed countries showed limited marginal value to NAT blood screening in improving blood safety. Reports on NAT results from Europe indicated yield of 1:0.6 million donations for HBV, <1:M for HCV and HIV-1-related to low prevalence of TTI. In contrast, prevalence of TTI in resource-limited countries is almost always high. As a result, more incident cases can be expected among first-time blood donors. Most reports of NAT blood donation screening in these countries showed NAT confirmed yield as high as 1/2800 for HBV and 1/3100 blood donations for HCV as reported from Thailand and Egypt, respectively. The issues for low resource countries are mostly the high cost of NAT but also the requirements of staff qualification, adequate facilities, reagent procurement and maintenance of delicate equipment. Alternatives to commercial NAT are the use of combos antigen-antibody for HIV and HCV, anti-HBc for HBV and in-house NAT. Most of these alternatives have been reported but very few comparisons are available. Once yield data is available, models for estimation of feasibility and cost-effectiveness are proposed to help decision-making. PMID:20079664

  5. Tensile and burning properties of clay/phenolic/GF composite and its application

    NASA Astrophysics Data System (ADS)

    Diharjo, Kuncoro; Armunanto, V. Bram; Kristiawan, S. Adi

    2016-03-01

    Composite material has been widely used in automotive due to its properties can be improved by combining with reinforcement, like fiber and particle to enhance mechanical properties and burning resistance. This study aims to investigate the tensile and burning properties of hybrid composite combining glass fiber and clay in phenolic resin. The clay was produced from roof tile rejected by tile industries in Sokka, Kebumen, Indonesia. The composite was made using a press mold method for different number of laminates and orientation of woven-roving-glass-fiber/ WRGF (0/90 and ±45), and the total volume fraction of fiber and clay is constant 40%. The specimens were tested using universal testing machine for tensile properties and burning tests apparatus for burning resistance (time to ignite/ TTI and burning rate/ BR). The enhancing of the Clay/Penolic/GF composite can be performed by the increasing of GF laminates, and the composite with 0/90 orientation of WRGF has higher tensile strength and modulus compared to that with ±45 orientation of WRGF. Both composite with 0/90 and ±45 orientation of WRGF have similar burning resistance (TTI and BR) and the composite containing 13 laminates of WR-GF shows the best burning resistance. According to these properties, this composite has good opportunity to be applied as car body panels or other structure in industries due to save weight and high burning resistance.

  6. Seasonal acclimation in sudomotor function evaluated by QSART in healthy humans

    PubMed Central

    Shin, Young Oh; Kim, Jeong-Ho

    2016-01-01

    The quantitative sudomotor axon reflex testing (QSART) is a classic test of routine postganglionic sudomotor function. We investigated sudomotor function by QSART after summer (July 2012) and winter (January 2013) seasonal acclimation (SA) in the Republic of Korea. QSART with acetylcholine (ACh) iontophoresis were performed to determine directly activated (DIR) and axon reflex-mediated (AXR1, 2) sweating rate. Onset time of axon reflex, activated sweat gland density (ASGD), activated sweat gland output (ASGO), tympanic and skin temperatures (Tty, Tsk), basal metabolic rate (BMR), and evaporative loss volume changes were measured. Tympanic and mean body temperature (Tb; calculated from Tty, Tsk) were significantly lower after summer-SA than that of winter-SA. Sweat onset time was delayed during winter-SA compared to that after summer-SA. BMR, AXR(1), AXR(2), and DIR sweat rates, ASGD and ASGO, and evaporative loss volume were significantly diminished after winter-SA relative to after summer-SA. In conclusion, changes in sweating activity measured by QSART confirmed the involvement of the peripheral nervous system in variation of sudomotor activity in seasonal acclimation. PMID:27610036

  7. Thermoregulatory responses during exercise and a hot water immersion and the affective responses to peripheral thermal stimuli

    NASA Astrophysics Data System (ADS)

    Fujishima, K.

    1986-03-01

    Tympanic (Tty), mean skin (¯Tsk) and mean body (¯Tb) temperatures and heart rate (HR) increased more in low Vo2 max group (LG) than in high Vo2 max group (HG) during exercise. The regression coefficient of body temperatures (Tty and ¯Tb) on HR and the increased rate of heat storage were larger in LG than in HG during exercise. The local sweat rate (per min/cm2) during a hot water bath exhibited a considerable large quantity in comparison with the amount during exercise. Internal and skin temperatures during a hot water bath increased more immediately than those during exercise. The levels of comfort sensation during the preovulatory phase in women and pre-exercise period in men were higher at 40‡C than at 20‡C as peripheral thermal stimulus. The levels during the postovulatory and post-exercise phases in the same subjects were higher with the cool stimuli than with the warm stimuli. Above results suggest that thermoregulatory responses during submaximal exercise are different according to physical fitness and that these responses are different from those during hot water immersion. In addition, these suggest that the scores of thermal sensation with warm and cool stimuli are different during the pre- and post-ovulatory phases and the pre- and post-exercise periods.

  8. A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling.

    PubMed

    Wang, Yifan; Xu, Qikai; Sack, Laura; Kang, Chanhee; Elledge, Stephen J

    2016-02-01

    Senescence stimuli activate multiple tumor suppressor pathways to initiate cycle arrest and a differentiation program characteristic of senescent cells. We performed a two-stage, gain-of-function screen to select for the genes whose enhanced expression can bypass replicative senescence. We uncovered multiple genes known to be involved in p53 and Rb regulation and ATM regulation, two components of the CST (CTC1-STN1-TEN1) complex involved in preventing telomere erosion, and genes such as REST and FOXO4 that have been implicated in aging. Among the new genes now implicated in senescence, we identified DLX2, a homeobox transcription factor that has been shown to be required for tumor growth and metastasis and is associated with poor cancer prognosis. Growth analysis showed that DLX2 expression led to increased cellular replicative life span. Our data suggest that DLX2 expression reduces the protein components of the TTI1/TTI2/TEL2 complex, a key complex required for the proper folding and stabilization of ATM and other members of the PIKK (phosphatidylinositol 3-kinase-related kinase) family kinase, leading to reduced ATM-p53 signaling and senescence bypass. We also found that the overexpression of DLX2 exhibited a mutually exclusive relationship with p53 alterations in cancer patients. Our functional screen identified novel players that may promote tumorigenesis by regulating the ATM-p53 pathway and senescence. PMID:26833729

  9. Thrombolysis in anterior versus posterior circulation strokes: timing of recanalization, ischemic tolerance, and other differences.

    PubMed

    Pagola, Jorge; Ribo, Marc; Alvarez-Sabin, José; Rubiera, Marta; Santamarina, Estevo; Maisterra, Olga; Delgado-Mederos, Raquel; Ortega, Gemma; Quintana, Manuel; Molina, Carlos A

    2011-04-01

    Previous studies have suggested a greater ischemic tolerance in posterior circulation as compared to anterior cerebral circulation. We aimed to investigate whether a differential response exists between anterior and posterior circulation strokes. Two hundred and four middle cerebral artery (MCA) patients and 28 basilar artery occlusion (BAO) patients treated with intravenous recombinant tissue plasminogen activator were included. Transcranial Doppler assessed recanalization at different time points. Patients were divided in three groups: total time of ischemia (TTI)<6, 6-24, or>24 hours. We calculated the percentage of recovery (admission National Institutes of Health Stroke Scale [NIHSS]- discharge NIHSS/admission NIHSS)×100. Mean time to treatment was longer in BAO patients (P=.031). Early recanalization was more frequent among MCA occlusions (41% vs 29%; P=.039); the rate of persisting occlusion at 24 hours was similar (P=.933). Clinical recovery according to TTI was similar in each group: <6 hours: BAO 84%/MCA 69%; 6-24 hours: BAO 63%/MCA 61%; >24 hours: BAO -44%/MCA 11% (P=.23). For each hour of ischemia MCA patients worsened 1.78% (P=.035) and BAO 1.76% (P=.421). MCA occlusions compared to BAO were independently associated with hemorrhagic transformation (OR: 8.2; P=.043). Our data do not support the theory of increased ischemic tolerance in posterior circulation. Despite longer time-to-treatment, BAO were more resistant to hemorrhagic transformations. PMID:20040010

  10. Optimization of Forward Wave Modeling on Contemporary HPC Architectures

    SciTech Connect

    Krueger, Jens; Micikevicius, Paulius; Williams, Samuel

    2012-07-20

    Reverse Time Migration (RTM) is one of the main approaches in the seismic processing industry for imaging the subsurface structure of the Earth. While RTM provides qualitative advantages over its predecessors, it has a high computational cost warranting implementation on HPC architectures. We focus on three progressively more complex kernels extracted from RTM: for isotropic (ISO), vertical transverse isotropic (VTI) and tilted transverse isotropic (TTI) media. In this work, we examine performance optimization of forward wave modeling, which describes the computational kernels used in RTM, on emerging multi- and manycore processors and introduce a novel common subexpression elimination optimization for TTI kernels. We compare attained performance and energy efficiency in both the single-node and distributed memory environments in order to satisfy industry’s demands for fidelity, performance, and energy efficiency. Moreover, we discuss the interplay between architecture (chip and system) and optimizations (both on-node computation) highlighting the importance of NUMA-aware approaches to MPI communication. Ultimately, our results show we can improve CPU energy efficiency by more than 10× on Magny Cours nodes while acceleration via multiple GPUs can surpass the energy-efficient Intel Sandy Bridge by as much as 3.6×.

  11. PP/PS anisotropic stereotomography

    NASA Astrophysics Data System (ADS)

    Nag, Steinar; Alerini, Mathias; Ursin, Bjørn

    2010-04-01

    Stereotomography is a slope tomographic method which gives good results for background velocity model estimation in 2-D isotropic media. We develop here the extension of the method to 3-D general anisotropic media for PP and PS events. We do not take into account the issue of shear wave degeneracy. As in isotropic media, the sensitivity matrix of the inversion can be computed by paraxial ray tracing. We introduce a `constant Z stereotomography' approach, which can reduce the size of the sensitivity matrix. Based on ray perturbation theory, we give all the derivatives of stereotomography data parameters with respect to model parameters in a 3-D general anisotropic medium. These general formulas for the derivatives can also be used in other applications that rely on anisotropic ray perturbation theory. In particular, we obtain derivatives of the phase velocity with respect to position, phase angle and elastic medium parameters, all for general anisotropic media. The derivatives are expressed using the Voigt notation for the elastic medium parameters. We include a Jacobian that allows to change the model parametrization from Voigt to Thomsen parameters. Explicit expressions for the derivatives of the data are given for the case of 2-D tilted transversely isotropic (TTI) media. We validate the method by single-parameter estimation of each Thomsen parameter field of a 2-D TTI synthetic model, where data are modelled by ray tracing. For each Thomsen parameter, the estimated velocity field fits well with the true velocity field.

  12. An integrated GPS-FID system for airborne gas detection of pipeline right-of-ways

    SciTech Connect

    Gehue, H.L.; Sommer, P.

    1996-12-31

    Pipeline integrity, safety and environmental concerns are of prime importance in the Canadian natural gas industry. Terramatic Technology Inc. (TTI) has developed an integrated GPS/FID gas detection system known as TTI-AirTrac{trademark} for use in airborne gas detection (AGD) along pipeline right-of-ways. The Flame Ionization Detector (FID), which has traditionally been used to monitor air quality for gas plants and refineries, has been integrated with the Global Positioning System (GPS) via a 486 DX2-50 computer and specialized open architecture data acquisition software. The purpose of this technology marriage is to be able to continuously monitor air quality during airborne pipeline inspection. Event tagging from visual surveillance is used to determine an explanation of any delta line deviations (DLD). These deviations are an indication of hydrocarbon gases present in the plume that the aircraft has passed through. The role of the GPS system is to provide mapping information and coordinate data for ground inspections. The ground based inspection using a handheld multi gas detector will confirm whether or not a leak exists.

  13. Stability analysis for acoustic wave propagation in tilted TI media by finite differences

    NASA Astrophysics Data System (ADS)

    Bakker, Peter M.; Duveneck, Eric

    2011-05-01

    Several papers in recent years have reported instabilities in P-wave modelling, based on an acoustic approximation, for inhomogeneous transversely isotropic media with tilted symmetry axis (TTI media). In particular, instabilities tend to occur if the axis of symmetry varies rapidly in combination with strong contrasts of medium parameters, which is typically the case at the foot of a steeply dipping salt flank. In a recent paper, we have proposed and demonstrated a P-wave modelling approach for TTI media, based on rotated stress and strain tensors, in which the wave equations reduce to a coupled set of two second-order partial differential equations for two scalar stress components: a normal component along the variable axis of symmetry and a lateral component of stress in the plane perpendicular to that axis. Spatially constant density is assumed in this approach. A numerical discretization scheme was proposed which uses discrete second-derivative operators for the non-mixed second-order derivatives in the wave equations, and combined first-derivative operators for the mixed second-order derivatives. This paper provides a complete and rigorous stability analysis, assuming a uniformly sampled grid. Although the spatial discretization operator for the TTI acoustic wave equation is not self-adjoint, this operator still defines a complete basis of eigenfunctions of the solution space, provided that the solution space is somewhat restricted at locations where the medium is elliptically anisotropic. First, a stability analysis is given for a discretization scheme, which is purely based on first-derivative operators. It is shown that the coefficients of the central difference operators should satisfy certain conditions. In view of numerical artefacts, such a discretization scheme is not attractive, and the non-mixed second-order derivatives of the wave equation are discretized directly by second-derivative operators. It is shown that this modification preserves

  14. Comparison of the Pentax Airwayscope, Glidescope Video Laryngoscope, and Macintosh Laryngoscope During Chest Compression According to Bed Height

    PubMed Central

    Kim, Wonhee; Lee, Yoonje; Kim, Changsun; Lim, Tae Ho; Oh, Jaehoon; Kang, Hyunggoo; Lee, Sanghyun

    2016-01-01

    Abstract We aimed to investigate whether bed height affects intubation performance in the setting of cardiopulmonary resuscitation and which type of laryngoscope shows the best performance at each bed height. A randomized crossover manikin study was conducted. Twenty-one participants were enrolled, and they were randomly allocated to 2 groups: group A (n = 10) and group B (n = 11). The participants underwent emergency endotracheal intubation (ETI) using the Airwayscope (AWS), Glidescope video laryngoscope, and Macintosh laryngoscope in random order while chest compression was performed. Each ETI was conducted at 2 levels of bed height (minimum bed height: 68.9 cm and maximum bed height: 101.3 cm). The primary outcomes were the time to intubation (TTI) and the success rate of ETI. The P value for statistical significance was set at 0.05 and 0.017 in post-hoc test. The success rate of ETI was always 100% regardless of the type of laryngoscope or the bed height. TTI was not significantly different between the 2 bed heights regardless of the type of laryngoscope (all P > 0.05). The time for AWS was the shortest among the 3 laryngoscopes at both bed heights (13.7 ± 3.6 at the minimum bed height and 13.4 ± 4.7 at the maximum bed height) (all P < 0.017). The TTI of Glidescope video laryngoscope was not significantly shorter than that of Macintosh laryngoscope at the minimum height (17.6 ± 4.0 vs 19.6 ± 4.8; P = 0.02). The bed height, whether adjusted to the minimum or maximum setting, did not affect intubation performance. In addition, regardless of the bed height, the intubation time with the video laryngoscopes, especially AWS, was significantly shorter than that with the direct laryngoscope during chest compression. PMID:26844477

  15. Comparison of the Pentax Airwayscope, Glidescope Video Laryngoscope, and Macintosh Laryngoscope During Chest Compression According to Bed Height.

    PubMed

    Kim, Wonhee; Lee, Yoonje; Kim, Changsun; Lim, Tae Ho; Oh, Jaehoon; Kang, Hyunggoo; Lee, Sanghyun

    2016-02-01

    We aimed to investigate whether bed height affects intubation performance in the setting of cardiopulmonary resuscitation and which type of laryngoscope shows the best performance at each bed height.A randomized crossover manikin study was conducted. Twenty-one participants were enrolled, and they were randomly allocated to 2 groups: group A (n = 10) and group B (n = 11). The participants underwent emergency endotracheal intubation (ETI) using the Airwayscope (AWS), Glidescope video laryngoscope, and Macintosh laryngoscope in random order while chest compression was performed. Each ETI was conducted at 2 levels of bed height (minimum bed height: 68.9  cm and maximum bed height: 101.3 cm). The primary outcomes were the time to intubation (TTI) and the success rate of ETI. The P value for statistical significance was set at 0.05 and 0.017 in post-hoc test.The success rate of ETI was always 100% regardless of the type of laryngoscope or the bed height. TTI was not significantly different between the 2 bed heights regardless of the type of laryngoscope (all P > 0.05). The time for AWS was the shortest among the 3 laryngoscopes at both bed heights (13.7  ±  3.6 at the minimum bed height and 13.4  ±  4.7 at the maximum bed height) (all P < 0.017). The TTI of Glidescope video laryngoscope was not significantly shorter than that of Macintosh laryngoscope at the minimum height (17.6  ±  4.0 vs 19.6  ±  4.8; P = 0.02).The bed height, whether adjusted to the minimum or maximum setting, did not affect intubation performance. In addition, regardless of the bed height, the intubation time with the video laryngoscopes, especially AWS, was significantly shorter than that with the direct laryngoscope during chest compression. PMID:26844477

  16. Slowed muscle oxygen uptake kinetics with raised metabolism are not dependent on blood flow or recruitment dynamics.

    PubMed

    Wüst, Rob C I; McDonald, James R; Sun, Yi; Ferguson, Brian S; Rogatzki, Matthew J; Spires, Jessica; Kowalchuk, John M; Gladden, L Bruce; Rossiter, Harry B

    2014-04-15

    Oxygen uptake kinetics (τVO2) are slowed when exercise is initiated from a raised metabolic rate. Whether this reflects the recruitment of muscle fibres differing in oxidative capacity, or slowed blood flow (Q) kinetics is unclear. This study determined τVO2 in canine muscle in situ, with experimental control over muscle activation and Q during contractions initiated from rest and a raised metabolic rate. The gastrocnemius complex of nine anaesthetised, ventilated dogs was isolated and attached to a force transducer. Isometric tetanic contractions (50 Hz; 200 ms duration) via supramaximal sciatic nerve stimulation were used to manipulate metabolic rate: 3 min stimulation at 0.33 Hz (S1), followed by 3 min at 0.67 Hz (S2). Circulation was initially intact (SPON), and subsequently isolated for pump-perfusion (PUMP) above the greatest value in SPON. Muscle VO2 was determined contraction-by-contraction using an ultrasonic flowmeter and venous oximeter, and normalised to tension-time integral (TTI). τVO2/TTI and τQ were less in S1SPON (mean ± s.d.: 13 ± 3 s and 12 ± 4 s, respectively) than in S2SPON (29 ± 19 s and 31 ± 13 s, respectively; P < 0.05). τVO2/TTI was unchanged by pump-perfusion (S1PUMP, 12 ± 4 s; S2PUMP, 24 ± 6 s; P < 0.001) despite increased O2 delivery; at S2 onset, venous O2 saturation was 21 ± 4% and 65 ± 5% in SPON and PUMP, respectively. VO2 kinetics remained slowed when contractions were initiated from a raised metabolic rate despite uniform muscle stimulation and increased O2 delivery. The intracellular mechanism may relate to a falling energy state, approaching saturating ADP concentration, and/or slowed mitochondrial activation; but further study is required. These data add to the evidence that muscle VO2 control is more complex than previously suggested. PMID:24469073

  17. Continuous Non-Invasive Monitoring of Tidal Volumes by Measurement of Tidal Impedance in Neonatal Piglets

    PubMed Central

    Kurth, Florian; Zinnow, Fabienne; Prakapenia, Alexandra; Dietl, Sabrina; Winkler, Stefan; Ifflaender, Sascha; Rüdiger, Mario; Burkhardt, Wolfram

    2011-01-01

    Background Electrical Impedance measurements can be used to estimate the content of intra-thoracic air and thereby give information on pulmonary ventilation. Conventional Impedance measurements mainly indicate relative changes, but no information concerning air-volume is given. The study was performed to test whether a 3-point-calibration with known tidal volumes (VT) during conventional mechanical ventilation (CMV) allows subsequent calculation of VT from total Tidal-Impedance (tTI) measurements using Quadrant Impedance Measurement (QIM). In addition the distribution of TI in different regions of the thorax was examined. Methodology and Principal Findings QIM was performed in five neonatal piglets during volume-controlled CMV. tTI values at three different VT (4, 6, 8 ml/kg) were used to establish individual calibration curves. Subsequently, each animal was ventilated with different patterns of varying VT (2–10 ml/kg) at different PEEP levels (0, 3, 6, 9, 12 cmH2O). VT variation was repeated after surfactant depletion by bronchoalveolar lavage. VT was calculated from tTI values (VTcalc) and compared to the VT delivered by the ventilator (VTPNT). Bland-Altman analysis revealed good agreement between VTcalc and VTPNT before (bias −0.08 ml; limits of agreement −1.18 to 1.02 ml at PEEP = 3 cmH2O) and after surfactant depletion (bias −0.17 ml; limits of agreement −1.57 to 1.22 ml at PEEP = 3 cmH2O). At higher PEEP levels VTcalc was lower than VTPNT, when only one fixed calibration curve (at PEEP 3 cmH2O) was used. With a new calibration curve at each PEEP level the method showed similar accuracy at each PEEP level. TI showed a homogeneous distribution over the four assessed quadrants with a shift toward caudal regions of the thorax with increasing VT. Conclusion Tidal Impedance values could be used for precise and accurate calculation of VT during CMV in this animal study, when calibrated at each PEEP level. PMID:21687746

  18. Effect of single flame retardant aluminum tri-hydroxide and boric acid against inflammability and biodegradability of recycled PP/KF composites

    NASA Astrophysics Data System (ADS)

    Suharty, Neng Sri; Dihardjo, Kuncoro; Handayani, Desi Suci; Firdaus, Maulidan

    2016-03-01

    Composites rPP/DVB/AA/KF had been reactively synthesized in melt using starting material: recycled polypropylene (rPP), kenaf fiber (KF), multifunctional compound acrylic acid (AA), compatibilizer divinyl benzene (DVB). To improve the inflammability of composites, single flame retardant aluminum tri-hydroxide (ATH) and boric acid (BA) as an additive was added. The inflammability of the composites was tested according to ASTM D635. By using 20% ATH and 5% BA additive in the composites it is effectively inhibiting its time to ignition (TTI). Its burning rate (BR) can be reduced and its heat realease (%HR) decreases. The biodegradability of composites was quantified by its losing weight (LW) of composites after buried for 4 months in the media with rich cellulolytic bacteria. The result shows that the LW of composites in the presence 20% ATH and 5% BA is 6.3%.

  19. Laboratory data manipulation tools basic data handling programs. Volume 2: Detailed software/hardware documentation

    NASA Technical Reports Server (NTRS)

    1981-01-01

    The set of computer programs described allows for data definition, data input, and data transfer between the LSI-11 microcomputers and the VAX-11/780 minicomputer. Program VAXCOM allows for a simple method of textual file transfer from the LSI to the VAX. Program LSICOM allows for easy file transfer from the VAX to the LSI. Program TTY changes the LSI-11 operators console to the LSI's printing device. Program DICTIN provides a means for defining a data set for input to either computer. Program DATAIN is a simple to operate data entry program which is capable of building data files on either machine. Program LEDITV is an extremely powerful, easy to use, line oriented text editor. Program COPYSBF is designed to print out textual files on the line printer without character loss from FORTRAN carriage control or wide record transfer.

  20. Reverse time migration in tilted transversely isotropic media

    SciTech Connect

    Zhang, Linbing; Rector III, James W.; Hoversten, G. Michael

    2004-07-01

    This paper presents a reverse time migration (RTM) method for the migration of shot records in tilted transversely isotropic (TTI) media. It is based on the tilted TI acoustic wave equation that was derived from the dispersion relation. The RTM is a full depth migration allowing for velocity to vary laterally as well as vertically and has no dip limitations. The wave equation is solved by a tenth-order finite difference scheme. Using 2D numerical models, we demonstrate that ignoring the tilt angle will introduce both lateral and vertical shifts in imaging. The shifts can be larger than 0.5 wavelength in the vertical direction and 1.5 wavelength in the lateral direction.

  1. What Does Tympanostomy Tube Placement in Children Teach Us About the Association Between Atopic Conditions and Otitis Media?

    PubMed Central

    Juhn, Young J.; Wi, Chung-Il

    2014-01-01

    Otitis media is the most common infection second only to viral upper respiratory infection in the outpatient setting. Tympanostomy tube insertion (TTI) is the most common ambulatory surgical procedure in the United States. While many risk factors for otitis media have been identified, atopic conditions have been under-recognized as risk factors for recurrent and persistent otitis media. Given that asthma and other atopic conditions are the most common chronic conditions during childhood, it is worth examining the association between atopic conditions and risk of otitis media, which can provide insight into how atopic conditions influence the risk of microbial infections. This paper focuses its discussion on otitis media, however it is important that the association between atopic conditions and risk of otitis media be interpreted in the context of the association of atopic conditions with increased risks of various microbial infections. PMID:24816652

  2. DABI: A data base for image analysis with nondeterministic inference capability

    NASA Technical Reports Server (NTRS)

    Yakimovsky, Y.; Cunningham, R.

    1976-01-01

    A description is given of the data base used in the perception subsystem of the Mars robot vehicle prototype being implemented at the Jet Propulsion Laboratory. This data base contains two types of information. The first is generic (uninstantiated, abstract) information that specifies the general rules of perception of objects in the expected environments. The second kind of information is a specific (instantiated) description of a structure, i.e., the properties and relations of objects in the specific case being analyzed. The generic knowledge can be used by the approximate reasoning subsystem to obtain information on the specific structures which is not directly measurable by the sensory instruments. Raw measurements are input either from the sensory instruments or a human operator using a CRT or a TTY.

  3. Comparison of the McGrath MAC video laryngoscope and the Pentax Airwayscope during chest compression: a manikin study.

    PubMed

    Kotera, Atsushi; Irie, Hiroki; Iwashita, Shinsuke; Taniguchi, Junichi; Kasaoka, Shunji; Kinoshita, Yoshihiro

    2014-01-01

    We tested the utility of the McGrath MAC(®) (McG) video laryngoscope during chest compression compared with the Pentax Airwayscope(®) (AWS). We recruited 59 participants into the simulation study. The difference in the time to intubation (TTI [sec]) between without and with chest compression was significant for the AWS attempts (median 13, range 6-28 vs. median 15, range 6-72, p = 0.0247) but not significant for the McG attempts (median 16, range 6-75 vs. median 16, range 6-71); however, the difference of the TTIs is not serious clinically. The utility of the two devices during chest compressions is almost similar although their characteristics are different. PMID:25520833

  4. Lupus anticoagulants: pathogenesis and laboratory diagnosis.

    PubMed

    Court, E L

    1997-12-01

    The pathogenesis of the lupus anticoagulant (LA) has been the focus of much research over the past decade, and a plethora of laboratory tests have been developed to detect it. This essay reviews the nature of LA and its pathogenesis, and a number of approaches employed in its diagnosis. These range from well established tests such as the kaolin clotting time (KCT), activated partial thromboplastin time (APTT) and tissue thromboplastin inhibition test (TTI), to the 'newer' tests such as the dilute Russell's viper venom time (DRVVT) and more recent snake venom tests such as the textarin/ecarin ratio and Taipan snake venom time (TSVT). The criteria for diagnosis are discussed, including pre-analytical variables such as sample preparation, and the effects of therapeutic anticoagulants used to treat thrombotic manifestations of the syndrome or an underlying disease process. PMID:9624740

  5. Jet decorrelation and jet shapes at the Tevatron

    SciTech Connect

    Heuring, T.C.

    1996-07-01

    We present results on measurements of jet shapes and jet azimuthal decorrelation from {bar p}P collisions at {radical}s = 1.8 TeV using data collected during the 1992-1993 run of the Fermilab Tevatron. Jets are seen to narrow both with increasing Awe {sub TTY} and increasing rapidity. While HERWIG, a puritan shower Monte Carlo, predicts slightly narrower jets, it describes the trend of the data well; NO CD described qualitative features of the data but is sensitive to both renormalization scale and jet definitions. Jet azimuthal decorrelation has been measured out to five units of pseudorapidity. While next-to-leading order CD and a leading-log approximation based on BFKL resummation fail to reproduce the effect, HERWIG describes the data well.

  6. AI application in shoe industry CAD/CAM

    NASA Astrophysics Data System (ADS)

    Wang, He-Chen; Lou, Da-li; Wu, Xian; Song, Xiang; Yong, Jiang

    1991-03-01

    I t'' I S art I (. . I f i [: j iJ(F Of (AD/(AM ystrn Li I f I y tti 1 I E A I at. :)I) I I Cat I (:)fl ()f the sysLeni I nte? I C)fl . The sys tern f''ornlE a (. . ()rres1)ond i i''g I ast sty I e autc)rnat. c. a I I y that. userE I I ke DY I ntcrac I VE )r i C i D I C fuzzy and k:ricw I ece b((:tI (1(JE . F I na I I y t s at t I (i I e I rr()(_1kJ(:. :e tE(I1)() I C)gy i ieta

  7. Hypocoprins A–C: New Sesquiterpenoids from the Coprophilous Fungus Hypocopra rostrata

    PubMed Central

    2015-01-01

    Studies of the coprophilous fungus Hypocopra rostrata (TTI-0009, NRRL 66178) isolated from a sample of horse dung collected in Texas led to the isolation of three new sesquiterpenoids that we named hypocoprins A–C (1–3), together with the known fungal metabolite helvolic acid. The new metabolites have a distinctive ring system consisting of fused cyclopropane and cyclodecene units not previously reported from a fungal source. Compounds 1 and 3 moderately inhibited growth of Staphylococcus aureus. The structures of these metabolites were assigned mainly by analysis of 2D NMR and HRESITOFMS data. Relative and absolute configurations were assigned by interpretation of NMR J-values and NOESY data and by application of Mosher’s method. These results represent the first report of chemistry from any strain of the genus Hypocopra. PMID:25549014

  8. Constraints on the thermal history of the Dead-Sea Graben as revealed by coal ranks in deep boreholes

    NASA Astrophysics Data System (ADS)

    Feinstein, Shimon

    1987-09-01

    Coal ranks have been studied by vitrinite reflectance measurements in three boreholes; Zuk Tamrur 1 and Zohar 8 on the Judea Desert plateau (adjacent to the graben margin) and Amiaz 1 on a down-faulted block at the southwest Dead-Sea Graben. In the plateau boreholes, time-temperature index (TTI) calculations reveal that the coalification profile probably evolved under a Late Cretaceous thermal event with a thermal gradient of 35°-38°C/km followed by gradual decay to the present level c. 20°C/km by Miocene time. In Amiaz 1, the highest coal rank encountered, 0.5% Ro, is marginal for independent TTI calculations, however, some constraints on thermal history can be inferred. Stratigraphic and structural relationships between the 0.5% Ro isoreflectance in Amiaz 1 and the plateau boreholes reveals that most of the coalification measured in Amiaz 1 pre dates the formation of the graben and that an additional 3.4 km of Miocene-Holocene graben fill barely affected the coalification. Cessation of coalification despite increasing burial indicates that the post-Miocene thermal gradient in the Amiaz block could not have exceeded 20°-23°C/km. This finding is consistent with present day heat flow and other geophysical information. Tectonic models for the evolution of the Dead Sea Graben requiring a high thermal regime are inconsistent with the presented data. This raises questions as to the mechanism involved in the formation of rhomb-shaped grabens in general, on the one hand and for the hypothesis of the "leaky" nature of the Dead Sea transform north of the Gulf of Elat, on the other.

  9. Seroprevalence of Human Immunodeficiency Virus, Hepatitis B Virus, Hepatitis C Virus, and Treponema pallidum Infections among Blood Donors on Bioko Island, Equatorial Guinea

    PubMed Central

    Chen, Jiang-Tao; Eyi, Urbano Monsuy; Matesa, Rocio Apicante; Obono, Maximo Miko Ondo; Ehapo, Carlos Sala; Yang, Li-Ye; Yang, Hui; Yang, Hui-Tian; Lin, Min

    2015-01-01

    Background Regular screening of transfusion-transmissible infections (TTIs), such as human immunodeficiency virus (HIV), hepatitis B and hepatitis C virus (HBV and HCV, respectively), and Treponema pallidum, in blood donors is essential to guaranteeing clinical transfusion safety. This study aimed to determine the seroprevalence of four TTIs among blood donors on Bioko Island, Equatorial Guinea (EG). Methods A retrospective survey of blood donors from January 2011 to April 2013 was conducted to assess the presence of HIV, HBV, HCV and T. pallidum. The medical records were analyzed to verify the seroprevalence of these TTIs among blood donations stratified by gender, age and geographical region. Results Of the total 2937 consecutive blood donors, 1098 (37.39%) had a minimum of one TTI and 185 (6.29%) harbored co-infections. The general seroprevalence of HIV, HBV, HCV and T. pallidum were 7.83%, 10.01%, 3.71% and 21.51%, respectively. The most frequent TTI co-infections were HBV-T. pallidum 60 (2.04%) and HIV-T. pallidum 46 (1.57%). The seroprevalence of HIV, HBV, HCV and T. pallidum were highest among blood donors 38 to 47 years, 18 to 27 years and ≥ 48 years age, respectively (P<0.05). The seroprevalence of TTIs varied according to the population from which the blood was collected on Bioko Island. Conclusions Our results firstly provide a comprehensive overview of TTIs among blood donors on Bioko Island. Strict screening of blood donors and improved hematological examinations using standard operating procedures are recommended. PMID:26448460

  10. Prediction of severe thunderstorms over Sriharikota Island by using the WRF-ARW operational model

    NASA Astrophysics Data System (ADS)

    Papa Rao, G.; Rajasekhar, M.; Pushpa Saroja, R.; Sreeshna, T.; Rajeevan, M.; Ramakrishna, S. S. V. S.

    2016-05-01

    Operational short range prediction of Meso-scale thunderstorms for Sriharikota(13.7°N ,80.18°E) has been performed using two nested domains 27 & 9Km configuration of Weather Research & Forecasting-Advanced Research Weather Model (WRF- ARW V3.4).Thunderstorm is a Mesoscale system with spatial scale of few kilometers to a couple of 100 kilometers and time scale of less than an one hour to several hours, which produces heavy rain, lightning, thunder, surface wind squalls and down-bursts. Numerical study of Thunderstorms at Sriharikota and its neighborhood have been discussed with its antecedent thermodynamic stability indices and Parameters that are usually favorable for the development of convective instability based on WRF ARW model predictions. Instability is a prerequisite for the occurrence of severe weather, the greater the instability, the greater will be the potential of thunderstorm. In the present study, K Index, Total totals Index (TTI), Convective Available Potential Energy (CAPE), Convective Inhibition Energy (CINE), Lifted Index (LI), Precipitable Water (PW), etc. are the instability indices used for the short range prediction of thunderstorms. In this study we have made an attempt to estimate the skill of WRF ARW predictability and diagnosed three thunderstorms that occurred during the late evening to late night of 31st July, 20th September and 2nd October of 2015 over Sriharikota Island which are validated with Local Electric Field Mill (EFM), rainfall observations and Chennai Doppler Weather Radar products. The model predicted thermodynamic indices (CAPE, CINE, K Index, LI, TTI and PW) over Sriharikota which act as good indicators for severe thunderstorm activity.

  11. Effects of respirator ambient air cooling on thermophysiological responses and comfort sensations.

    PubMed

    Caretti, David M; Barker, Daniel J

    2014-01-01

    This investigation assessed the thermophysiological and subjective impacts of different respirator ambient air cooling options while wearing chemical and biological personal protective equipment in a warm environment (32.7 ± 0.4°C, 49.6 ± 6.5% RH). Ten volunteers participated in 90-min heat exposure trials with and without respirator (Control) wear and performed computer-generated tasks while seated. Ambient air cooling was provided to respirators modified to blow air to the forehead (FHC) or to the forehead and the breathing zone (BZC) of a full-facepiece air-purifying respirator using a low-flow (45 L·min(-1)) mini-blower. An unmodified respirator (APR) trial was also completed. The highest body temperatures (TTY) and least favorable comfort ratings were observed for the APR condition. With ambient cooling over the last 60 min of heat exposure, TTY averaged 37.4 ± 0.6°C for Control, 38.0 ± 0.4°C for APR, 37.8 ± 0.5°C for FHC, and 37.6 ± 0.7°C for BZC conditions independent of time. Both the FHC and BZC ambient air cooling conditions reduced facial skin temperatures, reduced the rise in body temperatures, and led to more favorable subjective comfort and thermal sensation ratings over time compared to the APR condition; however statistical differences among conditions were inconsistent. Independent of exposure time, average breathing apparatus comfort scores with BZC (7.2 ± 2.5) were significantly different from both Control (8.9 ± 1.4) and APR (6.5 ± 2.2) conditions when ambient cooling was activated. These findings suggest that low-flow ambient air cooling of the face under low work rate conditions and mild hyperthermia may be a practical method to minimize the thermophysiological strain and reduce perceived respirator discomfort. PMID:24730706

  12. Non Infectious Complications Related to Blood Transfusion: An 11 year Retrospective Analysis in a Tertiary Care Hospital.

    PubMed

    Philip, J; Pawar, A; Chatterjee, T; Mallhi, R S; Biswas, A K; Dimri, U

    2016-09-01

    In India transmission of transfusion transmissible infections (TTI) has shown a relative decrease as a result of mandatory screening of donated blood for TTI's. However, reducing the incidence of non infectious complications poses a major challenge, mainly due to the fact that a number of adverse reactions go unreported. Blood transfusion reaction, can be categorized based on the time interval between transfusion of blood products and the presentation of adverse reactions as acute i.e. those presenting during or within 24 h and as delayed i.e. those presenting anytime after 24 h. Transfusion reactions can further be classified as immune and non immune or infectious and non infectious based on the pathophysiology. In this retrospective study which was undertaken with an aim to determine the type and frequency of non infectious complications due to transfusion of blood and blood products recorded the incidence of febrile non hemolytic transfusion reactions (FNHTR) 51.40 %, allergic reactions 40.14 %, non immune hemolytic reactions 4.22 %, hypothermia 2.81 %, anaphylaxis 0.70 % and iron overload 0.70 %. FNHTR which was found to be the most common complication in this study can certainly be minimized, if not completely eliminated by adopting a policy of universal leucodepletion, the implementation of which solely depends on the financial and infrastructure resources available. This study also reiterates the importance of hemovigilance as a tool to improve the safety of blood transfusion. PMID:27429521

  13. Effect of cyclical thermal to mechanical properties of Hybrid Laminate Composites (HLC) with skin recycle polypropylene/natural fiber/halloysite and core PP/KF composites

    NASA Astrophysics Data System (ADS)

    Sri Suharty, Neng; Ismail, Hanafi; Suci Handayani, Desi; Diharjo, Kuncoro; Rachman Wibowo, Fajar; Arnita Wuri, Margaretha

    2016-02-01

    This research has successfully synthesized six hybrid laminate composites (HLC). These HLC consist of two layers skin composites and one layer of core PP/KF composites. There are sticked with epoxy adhesive by using cold press method. In this research 6 types of skin are used, namely the rPP (recycled polypropylene, HC1); rPP/DVB/PP-g-AA/KF (HC2); rPP/DVB/PP-g-AA/Hall (HC3); rPP/DVB/PP-g-AA/Hall+ZB (HC4); rPP/DVB/PP-g-AA/KF/Hall (HC5) and rPP/DVB/PP-g-AA/KF/Hall+ZB (HC6) composites. The mechanical properties assessment tensile strength (TS) of various HLC before and after cyclical thermal (CT) was done by ASTM D638. While testing the flame retardant: such as time to ignition (TTI) and burning rate (BR) was done by ASTM D635. Heat stability of HLC can be recognized by conducting the CT treatment. It is to determine the effect of fluctuating heat loads on mechanical properties of HLC materials. The TS result of five HLCs (HC2, HC3, HC4, HC5 and HC6) before CT treatment were higher than HC1 (blank HLC). Those five HLC are also able to increase the TTI and reduce the BR compared to HC1. The CT treatment conditions performed at 45 oC as much as 125 times. After CT treatment, the TS values only slightly decline compared to before CT treatment.

  14. Integrating sequence stratigraphy and rock-physics to interpret seismic amplitudes and predict reservoir quality

    NASA Astrophysics Data System (ADS)

    Dutta, Tanima

    improves the predictions of shear wave velocities. In addition, we provide empirical relations on normal compaction depth trends of porosity, velocities, and VP/VS ratio for shale and clean sands in shallow, supra-salt sediments in the Gulf of Mexico. Next, we identify probable spatial trends of sand/shale ratio and sorting as predicted by the conventional sequence stratigraphic model in minibasin settings (spill-and-fill model). These spatial trends are evaluated using well data from offshore West Africa, and the same well data are used to calibrate rock physics models (modified soft-sand model) that provide links between P-impedance and quartz/clay ratio, and sorting. The spatial increase in sand/shale ratio and sorting corresponds to an overall increase in P-impedance, and AVO intercept and gradient. The results are used as a guide to interpret sedimentological parameters from seismic attributes, away from the well locations. We present a quantitative link between carbonate cement and seismic attributes by combining stratigraphie cycles and the rock physics model (modified differential effective medium model). The variation in carbonate cement volume in West Africa can be linked with two distinct stratigraphic cycles: the coarsening-upward cycles and the fining-upward cycles. Cemented sandstones associated with these cycles exhibit distinct signatures on P-impedance vs. porosity and AVO intercept vs. gradient crossplots. These observations are important for assessing reservoir properties in the West Africa as well as in other analogous depositional environments. Finally, we investigate the relationship between seismic velocities and time temperature index (TTI) using basin and petroleum system modeling at Rio Muni basin, West Africa. We find that both VP and VS increase exponentially with TTI. The results can be applied to predict TTI, and thereby thermal maturity, from observed velocities.

  15. Verification of a two-dimensional infiltration model for the resin transfer molding process

    NASA Technical Reports Server (NTRS)

    Hammond, Vincent H.; Loos, Alfred C.; Dexter, H. Benson; Hasko, Gregory H.

    1993-01-01

    A two-dimensional finite element model for the infiltration of a dry textile preform by an injected resin was verified. The model, which is based on the finite element/control volume technique, determines the total infiltration time and the pressure increase at the mold inlet associated with the RTM process. Important input data for the model are the compaction and permeability behavior of the preform along with the kinetic and rheological behavior of the resin. The compaction behavior for several textile preforms was determined by experimental methods. A power law regression model was used to relate fiber volume fraction to the applied compaction pressure. Results showed a large increase in fiber volume fraction with the initial application of pressure. However, as the maximum fiber volume fraction was approached, the amount of compaction pressure required to decrease the porosity of the preform rapidly increased. Similarly, a power law regression model was used to relate permeability to the fiber volume fraction of the preform. Two methods were used to measure the permeability of the textile preform. The first, known as the steady state method, measures the permeability of a saturated preform under constant flow rate conditions. The second, denoted the advancing front method, determines the permeability of a dry preform to an infiltrating fluid. Water, corn oil, and an epoxy resin, Epon 815, were used to determine the effect of fluid type and viscosity on the steady state permeability behavior of the preform. Permeability values measured with the different fluids showed that fluid viscosity had no influence on the permeability behavior of 162 E-glass and TTI IM7/8HS preforms. Permeabilities measured from steady state and advancing front experiments for the warp direction of 162 E-glass fabric were similar. This behavior was noticed for tests conducted with corn oil and Epon 815. Comparable behavior was observed for the warp direction of the TTI IM7/8HS preform

  16. Zircon trace element geochemistry and growth of the Pleistocene to Holocene Mono Craters rhyolite magma system, California (USA)

    NASA Astrophysics Data System (ADS)

    Baker, N.; Miller, J. S.; Vazquez, J. A.; Marcaida, M.; Lidzbarski, M. I.

    2015-12-01

    The Mono Craters, part of the Mono-Inyo volcanic chain in eastern California, comprise at least 27 high-silica Pleistocene to Holocene rhyolite domes, lava flows and tephra cones. The Holocene chronology of the Mono Craters is well constrained but only recently has 238U-230Th zircon and 40Ar/39Ar dating elucidated the Pleistocene eruptive history. We performed trace element analysis on dated zircon crystal rims and sectioned interiors (using SHRIMP-RG) from 3 rhyolite domes (21, 12.5, and 7 ka) with additional rim data on 5 ashes separated from juvenile pumice clasts in the correlative Wilson Creek Formation (spanning from 62 to 21 ka). Ti-in-zircon (TTi,zrc) thermometry (titania activity from coexisting Fe-Ti oxides) gives temperatures predominantly between 650°C and 750°C, similar to average zircon saturation temperatures (Tzrc,sat). The observation that Tzrc,sat ≈ TTi,zrc indicates that Mono Craters rhyolite magmas were zircon-saturated and erupted at these temperatures (near water-saturated granite eutectic). Variations in key trace elements are relatively limited overall and zircons display similar REE patterns with generally curved MREE to HREE patterns and prominent negative Eu anomalies. Most of the variation is observed in zircons from older eruptions (62-41 ka). Zircon rims from Ash 17 of the Wilson Creek Formation (59 ka) have elevated Th/U, Eu/Eu*, and Ti and lower Hf compared to Ash 19 (62 ka), which suggests a thermal rejuvenation event between these two eruptions. Zircon rims from Ash 15 (41 ka) are characterized by a trend toward high Hf, at relatively low and relatively constant Ti, and low Eu/Eu*, consistent with rhyolite magma undergoing eutectic-like crystallization just prior to eruption. Zircon surfaces and interiors for the 21, 12.5, and 7 ka dome eruptions have very similar Hf, low Eu/Eu*, low Ti, and low Th/U. This requires zircon crystallization in a very uniform thermal and chemical environment from the latest Pleistocene to Holocene

  17. Veno-venous extracorporeal blood shunt cooling to induce mild hypothermia in dog experiments and review of cooling methods.

    PubMed

    Behringer, Wilhelm; Safar, Peter; Wu, Xianren; Nozari, Ala; Abdullah, Ali; Stezoski, S William; Tisherman, Samuel A

    2002-07-01

    Mild hypothermia (33-36 degrees C) might be beneficial when induced during or after insults to the brain (cardiac arrest, brain trauma, stroke), spinal cord (trauma), heart (acute myocardial infarction), or viscera (hemorrhagic shock). Reaching the target temperature rapidly in patients inside and outside hospitals remains a challenge. This study was to test the feasibility of veno-venous extracorporeal blood cooling for the rapid induction of mild hypothermia in dogs, using a simple pumping-cooling device. Ten custom-bred hunting dogs (21-28 kg) were lightly anesthetized and mechanically ventilated. In five dogs, two catheters were inserted through femoral veins, one peripheral and the other into the inferior vena cava. The catheters were connected via a coiled plastic tube as heat exchanger (15 m long, 3 mm inside diameter, 120 ml priming volume), which was immersed in an ice-water bath. A small roller-pump produced a veno-venous flow of 200 ml/min (about 10% of cardiac output). In five additional dogs (control group), a clinically practiced external cooling method was employed, using alcohol over the skin of the trunk and fanning plus ice-bags. During spontaneous normotension, veno-venous cooling delivered blood into the vena cava at 6.2 degrees C standard deviation (SD 1.4) and decreased tympanic membrane (Tty) temperature from 37.5 to 34.0 degrees C at 5.2 min (SD 0.7), and to 32.0 degrees C at 7.9 min (SD 1.3). Skin surface cooling decreased tympanic temperature from 37.5 to 34.0 degrees C at 19.9 min (SD 3.7), and to 32.0 degrees C at 29.9 (SD 5.1) (P=0.001). Heart rates at Tty 34 and 32 degrees C were significantly lower than at baseline in both groups, but within physiological range, without difference between groups. There were no arrhythmias. We conclude that in large dogs the induction of mild systemic hypothermia with extracorporeal veno-venous blood shunt cooling is simple and four times more rapid than skin surface cooling. PMID:12104113

  18. Prestack reverse time migration for tilted transversely isotropic media

    NASA Astrophysics Data System (ADS)

    Jang, Seonghyung; Hien, Doan Huy

    2013-04-01

    According to having interest in unconventional resource plays, anisotropy problem is naturally considered as an important step for improving the seismic image quality. Although it is well known prestack depth migration for the seismic reflection data is currently one of the powerful tools for imaging complex geological structures, it may lead to migration error without considering anisotropy. Asymptotic analysis of wave propagation in transversely isotropic (TI) media yields a dispersion relation of couple P- and SV wave modes that can be converted to a fourth order scalar partial differential equation (PDE). By setting the shear wave velocity equal zero, the fourth order PDE, called an acoustic wave equation for TI media, can be reduced to couple of second order PDE systems and we try to solve the second order PDE by the finite difference method (FDM). The result of this P wavefield simulation is kinematically similar to elastic and anisotropic wavefield simulation. We develop prestack depth migration algorithm for tilted transversely isotropic media using reverse time migration method (RTM). RTM is a method for imaging the subsurface using inner product of source wavefield extrapolation in forward and receiver wavefield extrapolation in backward. We show the subsurface image in TTI media using the inner product of partial derivative wavefield with respect to physical parameters and observation data. Since the partial derivative wavefields with respect to the physical parameters require extremely huge computing time, so we implemented the imaging condition by zero lag crosscorrelation of virtual source and back propagating wavefield instead of partial derivative wavefields. The virtual source is calculated directly by solving anisotropic acoustic wave equation, the back propagating wavefield on the other hand is calculated by the shot gather used as the source function in the anisotropic acoustic wave equation. According to the numerical model test for a simple

  19. Tandem-ring dwell time ratio in Nigeria: dose comparisons of two loading patterns in standard high-dose-rate brachytherapy planning for cervical cancer

    PubMed Central

    Ibhade, Obed Rachel; Idayat, Akinlade Bidemi; Atara I., Ntekim

    2015-01-01

    Purpose In high-dose-rate (HDR) brachytherapy (BT), the source dwell times and dwell positions are essential treatment planning parameters. An optimal choice of these factors is fundamental to obtain the desired target coverage with the lowest achievable dose to the organs at risk (OARs). This study evaluates relevant dose parameters in cervix brachytherapy in order to assess existing tandem-ring dwell time ratio used at the first HDR BT center in Nigeria, and compare it with an alternative source loading pattern. Material and methods At the Radiotherapy Department, University College Hospital (UCH), Ibadan, Nigeria, a total of 370 standard treatment plans in two alternative sets were generated with HDR basic 2.6 software for one hundred and eighty five cervical cancer patients. The initial 185 individual plans were created for clinical treatment using the tandem-ring dwell time ratio of 1 : 1. Modifying the initial applicator loading ratio, the second set of plans with related dose data were also obtained for study purposes only. Total reference air kerma (TRAK), total time index (TTI), ICRU volume, treatment time, point B dose, ICRU bladder dose, and rectal points dose were evaluated for both sets of plans. Results The means of all evaluated dose parameters decreased when the existing tandem-ring dwell time ratio (1 : 1) was modified to other dwell weightings (1 : 1 – 3 : 1). These reductions were 13.43% (ICRU volume), 9.83% (rectal dose), 6.68% (point B dose), 6.08% (treatment time), 5.90% (TRAK), 5.88% (TTI), and 1.08% (bladder dose). Correspondingly, coefficients of variation changed by –7.98%, –5.02%, –5.23%, –4.20%, –3.93%, 8.65%, and 3.96% from the existing pattern to the alternative one. Conclusion Tandem-ring dwell time ratio has significant influence on dosimetric parameters. This study has indicated the need to modify the existing planning approach at UCH. PMID:26034498

  20. Thermal maturation and petroleum source rocks in Forest City and Salina basins, mid-continent, U. S. A

    SciTech Connect

    Newell, K.D.; Watney, W.L.; Hatch, J.R.; Xiaozhong, G.

    1986-05-01

    Shales in the Middle Ordovician Simpson Group are probably the source rocks for a geochemically distinct group of lower pristane and low phytane oils produced along the axis of the Forest City basin, a shallow cratonic Paleozoic basin. These oils, termed Ordovician-type oils, occur in some fields in the southern portion of the adjacent Salina basin. Maturation modeling by time-temperature index (TTI) calculations indicate that maturation of both basins was minimal during the early Paleozoic. The rate of maturation significantly increased during the Pennsylvanian because of rapid regional subsidence in response to the downwarping of the nearby Anadarko basin. When estimated thicknesses of eroded Pennsylvanian, Permian, and Cretaceous strata are considered, both basins remain relatively shallow, with maximum basement burial probably not exceeding 2 km. According to maturation modeling and regional structure mapping, the axes of both basins should contain Simpson rocks in the early stages of oil generation. The probability of finding commercial accumulations of Ordovician-type oil along the northwest-southeast trending axis of the Salina basin will decrease in a northwestward direction because of (1) westward thinning of the Simpson Group, and (2) lesser maturation due to lower geothermal gradients and shallower paleoburial depths. The optimum localities for finding fields of Ordovician-type oil in the southern Salina basin will be in down-plunge closures on anticlines that have drainage areas near the basin axis.

  1. The development and implementation of theory-driven programs capable of addressing poverty-impacted children’s health, mental health and prevention needs: CHAMP and CHAMP+, evidence-informed, family-based interventions to address HIV risk and care

    PubMed Central

    McKay, Mary McKernan; Alicea, Stacey; Elwyn, Laura; McClain, Zachary R.B.; Parker, Gary; Small, Latoya A; Ann Mellins, Claude

    2014-01-01

    This article describes a program of prevention and intervention research conducted by the CHAMP (CHAMP – Collaborative HIV prevention and Adolescent Mental health Project; McKay & Paikoff, 2007) investigative team. CHAMP refers to a set of theory-driven, evidence-informed, collaboratively-designed, family-based approaches meant to address the prevention, health and mental health needs of poverty-impacted, African American and Latino urban youth who are either at risk for HIV exposure or who are perinatally-infected and at high risk for re-infection and possible transmission. CHAMP approaches are informed by theoretical frameworks that incorporate an understanding of the critical influences of multi-level contextual factors on youth risk taking and engagement in protective health behaviors. Highly influential theories include: the Triadic Theory of Influence (TTI) (Bell, Flay, & Paikoff, 2002), Social Action Theory (SAT) (Ewart, 1991) and Ecological Developmental Perspectives (Paikoff, Traube, & McKay, 2006). CHAMP program delivery strategies were developed via a highly collaborative process drawing upon community-based participatory research methods in order to enhance cultural and contextual sensitivity of program content and format. The development and preliminary outcomes associated with a family-based intervention for a new population, perinatally HIV-infected youth and their adult caregivers, referred to as CHAMP+, is described to illustrate the integration of theory, existing evidence and intensive input from consumers and healthcare providers. PMID:24787707

  2. Screening Donated Blood for Transfusion Transmitted Infections by Serology along with NAT and Response Rate to Notification of Reactive Results: An Indian Experience.

    PubMed

    Chaurasia, Rahul; Zaman, Shamsuz; Das, Bankim; Chatterjee, Kabita

    2014-01-01

    Background. Transfusion safety begins with healthy donors. A fundamental part of preventing transfusion transmitted infections (TTIs) is to notify and counsel reactive donors. Donor notification and counselling protect the health of the donor and prevent secondary transmission of infectious diseases. Methods. 113,014 donations were screened for TTIs, namely, HIV, HBV, HCV, and syphilis, by serology and nucleic acid testing. All reactive donors were retested (wherever possible) and notified of their status by telephone or letter. All initial reactive screens were followed over six months. Results. We evaluated 2,838 (2.51%) cases with reactive screening test results (1.38% HBV, 0.54% HCV, 0.27% HIV, and 0.32% syphilis). Only 23.3% of donors (662) responded to notification. The response among voluntary donors was better as compared to the replacement donors (43.6% versus 21.2%). Only 373 (56.3%) responsive donors followed their first attendance at referral specialties. Over six months, only 176 of 662 (26.6%) reactive donors received treatment. Conclusion. Our study shed light on the importance of proper donor counselling and notification of TTI status to all reactive donors who opt to receive this information. There is also an urgent need to formulate the nationally acceptable guidelines for notification and follow-up of reactive donors. PMID:25485163

  3. Measurement of 167Er(n,p)167Ho reaction at 13.5 and 14.8 MeV

    NASA Astrophysics Data System (ADS)

    Luo, Junhua; Liu, Jun; Han, Jiuning; Jiang, Li; Liu, Rong; Ge, Suhong; Liu, Zhenlai

    2013-11-01

    We have measured the 167Er(n,p)167Ho cross-sections at two different neutron energies 13.5 and 14.8 MeV. Measurements were performed at Pd-300 neutron generator of Chinese Academy of Engineering Physics (CAEP) with monoenergetic neutrons produced via the 3H(d,n)4He reaction using a tritium-titanium (T-Ti) target. Induced gamma activities were measured by a high-resolution gamma-ray spectrometer with high-purity germanium (HPGe) detector. The data for 167Er(n,p)167Ho reaction cross-sections are reported to be 2.2±0.6 and 2.8±1.4 mb at 13.5±0.2 and 14.8±0.2 MeV incident neutron energies, respectively. The cross sections were also estimated with the TALYS-1.4 nuclear model code and compared with experimental data found in the literature, and with the comprehensive evaluation data in ENDF/B-VII.1 and JEFF-3.1/A libraries.

  4. Epidemiology of Transfusion Transmitted Infection among Patients with β-Thalassaemia Major in Pakistan

    PubMed Central

    Ahmed Kiani, Rizwan; Anwar, Muhammad; Asad, Muhammad Javaid; Abbasi, Saleem; Abbas Zaheer, Hasan

    2016-01-01

    Introduction. Transfusion Transmitted Infections (TTIs) continue to be a major risk in transfusions in many parts of the world. The transfusion-dependent β-thalassaemia patients are particularly at risk of acquiring TTIs. The current study was undertaken to estimate the prevalence of TTIs in transfusion-dependent β-thalassaemia patients. Material and Methods. A cross-sectional study of 1253 multitransfused thalassaemia major patients was conducted in five different centres of Islamabad, Rawalpindi, and Karachi. The study subjects were screened for HIV, HCV, and HBV. The screening was performed at two centres: Department of Pathology, Shaheed Zulfiqar Ali Bhutto (SZAB) Medical University, and Blood Transfusion Services, Jinnah Postgraduate Medical Centre, from July to December 2015. The confirmatory screening was performed by Chemiluminescent Immunoassay (CLIA). Results. Out of the 1253 multiple transfused patients, 317 (25.3%) were infected with TTIs. HCV was positive in 273 cases (21.7%), HBV in 38 cases (3.0%), and HIV in 6 cases (0.5%). Conclusion. HCV was the leading TTI in multitransfused thalassaemia major patients in the study. Presence of HIV in thalassaemia patients is a recent disturbing development in Pakistan. Improved regulation of blood banks including use of internationally or nationally evaluated kits will bring down the incidence of TTIs in transfusion-dependent β-thalassaemia patients. More stringent behavioral and serological pretransfusion screening of blood for TTIs must be implemented in blood banks. PMID:27559490

  5. Hydrologic constraints on the thermal evolution of the Rhine Graben

    NASA Astrophysics Data System (ADS)

    Person, Mark; Garven, Grant

    The role of subsurface fluid flow in the thermal evolution of the Rhine Graben is investigated using transient finite element modeling. The analysis helps elucidate the importance of convective-heat transfer on the thermal maturation of organic matter in rift sediments and permits comparison of the different driving forces on fluids during basin development. Modeling results indicate that in Oligocene time, during a period of marine incursion, groundwater flow was driven by sediment compaction. Heat transfer during this time period was dominated by conduction, as groundwater velocities were too small to disturb the temperature field. Uplift of the Graben shoulders in conjunction with marine regression during Miocene to Recent times probably initiated a regional gravity-driven groundwater flow system. Convective-heat transfer during this period resulted in high heat flow (greater than 120 mW m-2) within ground-water discharge areas near the center of the rift and low heat flow (less than 20 mW m-2) within recharge areas near fault escarpments. Computed petroleum maturation indices (TTI) indicate that oil generation occurred much deeper in regions of groundwater recharge than in discharge areas. The model results are in good agreement with observed geothermie data and occurrences of petroleum within the rift.

  6. Lagrangian modelling of OPALE dataset.

    NASA Astrophysics Data System (ADS)

    Gil, Jaime E.; Thomas, Jennie; Bekki, Slimane; Kukui, Alexandre; Ancellet, Gerad; Preunkert, Susanne; Legrand, Michel; Frey, Markus; Savarino, Joel; Jourdain, Bruno; Kerbrat, Michel; France, James; King, Martin; Toumi, Ralf

    2013-04-01

    The OPALE measurement campaign aimed to characterize the atmospheric chemistry of the East Antarctic Plateau making a range of measurements at two sites, a coastal one, Dumont d'Urville (DDU) (From December 2010 until March 2011, 66o S, 123oE, coastal site) and on top of the Antarctic plateau Dome C (From December 2011 until January 2012 at Dome C, 75oS, 123o E, 3233 m a.s.l.). There are relatively few observations of chemistry occurring inland and coastal sites Antarctic sites. During the campaign air masses originating from the marine boundary layer, the free troposphere, the Antarctic continent, and of mixed origins were observed. We present analyses of chemical measurements (including O3, NO2, OH, RO2, hydrocarbons) using the CiTTyCAT photochemical trajectory model. The model simulates the chemistry of air masses over multiple (~5) days back trajectories provided by a stochastic trajectory model (FLEXPART). In some cases, the initial chemical conditions are taken from a chemistry-transport model (MOZART). The effect of clouds on the photolysis rates is also accounted for using MODIS satellite data. The model results are compared with measurements performed during both OPALE campaign years. Differences between the reactive nitrogen and hydroxyl radical chemistry at DDU and Dome C and the strong influence of reactive exchanges of trace gases between the snow and the atmosphere at Dome C are highlighted. The implications for the oxidizing capacity of the Antarctic boundary layer are also discussed.

  7. STS-96 crew takes part in payload Interface Verification Test

    NASA Technical Reports Server (NTRS)

    1999-01-01

    During a payload Interface Verification Test (IVT) in the SPACEHAB Facility, STS-96 Mission Specialist Valery Tokarev of Russia (second from left) and Commander Kent Rominger learn about the Sequential Shunt Unit (SSU) in front of them from Lynn Ashby (far right), with Johnson Space Center. At the far left looking on is TTI interpreter Valentina Maydell. Other crew members at KSC for the IVT are Pilot Rick Husband and Mission Specialists Ellen Ochoa, Tamara Jernigan, Dan Barry and Julie Payette. The SSU is part of the cargo on Mission STS-96, which carries the SPACEHAB Logistics Double Module, with equipment to further outfit the International Space Station service module and equipment that can be off-loaded from the early U.S. assembly flights. The SPACEHAB carries internal logistics and resupply cargo for station outfitting, plus an external Russian cargo crane to be mounted to the exterior of the Russian station segment and used to perform space walking maintenance activities. The double module stowage provides capacity of up to 10,000 lbs. with the ability to accommodate powered payloads, four external rooftop stowage locations, four double-rack locations (two powered), up to 61 bulkhead-mounted middeck locker locations, and floor storage for large unique items and Soft Stowage. STS-96 is targeted to launch May 20 about 9:32 a.m.

  8. Effect of cationic surfactants on characteristics and colorimetric behavior of polydiacetylene/silica nanocomposite as time-temperature indicator

    NASA Astrophysics Data System (ADS)

    Nopwinyuwong, Atchareeya; Kitaoka, Takuya; Boonsupthip, Waraporn; Pechyen, Chiravoot; Suppakul, Panuwat

    2014-09-01

    Polydiacetylene (PDA)/silica nanocomposites were synthesized by self-assembly method using polymerizable amphiphilic diacetylene monomers, 10,12-pentacosadiynoic acid (PCDA). Addition of cationic surfactants (PDADMAC and CTAB) to PDA/SiO2 nanocomposites induced higher intermolecular force which affected their size, shape and color transition. Pure PDA, PDA/SiO2, PDA/SiO2/PDADMAC and PDA/SiO2/CTAB were investigated by particle size analysis, TEM, SEM, UV-vis spectroscopy and FT-IR. It was found that the PDA/SiO2 nanocomposites exhibited slightly larger particle sizes than those of other samples. The PDA/SiO2 nanocomposites with a core-shell structure were almost regarded as spherical-shaped particles. Cationic surfactants, especially CTAB, presumably affected the particle size and shape of PDA/SiO2 nanocomposites due to the disruption of hydrogen bonding between PDA head group and ammonium group. The colorimetric response of both PDA/SiO2/surfactant and surfactant-free PDA/SiO2 aqueous solutions directly changed in relation to time and temperature; thus they were expected to be applied as a new polymer-based time-temperature indicator (TTI).

  9. Strong orbital fluctuations in multipolar ordered states of PrV2Al20

    NASA Astrophysics Data System (ADS)

    Matsumoto, Yosuke; Tsujimoto, Masaki; Tomita, Takahiro; Sakai, Akito; Nakatsuji, Satoru

    2016-02-01

    PrT2Al20 (T=Ti, V) are ideal systems to study the quadrupole Kondo effect and quantum criticality arising from orbital degrees of freedom. The both systems have the nonmagnetic cubic Γ3 crystal electric field ground doublet with the well separated excited state. In particular, PrV2Al20 exhibits anomalous metallic behavior above and below the multipolar ordering temperatures, reflecting the even stronger hybridization between f and conduction electrons possibly due to a proximity to an orbital quantum critical point. Here we report the anomalous metallic behaviors found in a pure single crystal of PrV2Al20. Our detailed analyses revealed that the resistivity indicates power law temperature dependence proportional to T3. Furthermore, we pointed out that the 4f electron contribution to the specific heat also exhibits power law behavior proportional to T4. Both observations are in a sharp contrast to the gapped behavior found in PrTi2Al20 and indicate the strong c-f hybridization and strong orbital fluctuations in PrV2Al20. In addition, the 4f electron contribution to the entropy in PrV2Al20 reaches only 50% of R ln 2 at an orbital ordering at T=0.75 K, suggesting another 50% of R ln 2 expected for Γ3 doublet is already released at higher temperature possibly due to quadrupole Kondo effect.

  10. Performance indicators: A tool for continuous quality improvement

    PubMed Central

    Bhatnagar, Nidhi M; Soni, Shital; Gajjar, Maitrey; Shah, Mamta; Shah, Sangita; Patel, Vaidehi

    2016-01-01

    Background: Performance monitoring is an important tool which can be used for setting priorities for process improvement. At our centre, we have been monitoring every step in the processes, right from inventory of consumables (both critical and routine) to number of donors reactive for TTI. We conducted a study to measure the impact of monitoring Performance Indicators and how it could be used as a tool for Continuous Quality Improvement (CQI). Materials and Methods: The present study was a retrospective study where the performance indicator (PI) data of blood bank was analyzed for over four years. For certain parameters, benchmarks or thresholds were set that represented warning limits or action limits. The yearly data were collated from monthly data. Shifts or Trends, if any, were identified and Corrective and Preventive Action (CAPA) taken accordingly. At the end, outcomes of the analysis were charted. Results: After the yearly data evaluation, outcomes obtained were used to plan, correct and amend processes and systems in the blood center. It was observed that the workload of the center showed an upward trend. This helped us to plan for the purchase of consumables and management of manpower. The monitoring of usage and discard of blood helped in the efficient management of blood stocks. The need for any new equipment could also be judged by the trends in workload. Conclusion: Performance indicators are indispensible tools which various stakeholders in the Blood Transfusion centres should implement to improve on quality performance. PMID:27011669

  11. Epidemiology of Transfusion Transmitted Infection among Patients with β-Thalassaemia Major in Pakistan.

    PubMed

    Ahmed Kiani, Rizwan; Anwar, Muhammad; Waheed, Usman; Asad, Muhammad Javaid; Abbasi, Saleem; Abbas Zaheer, Hasan

    2016-01-01

    Introduction. Transfusion Transmitted Infections (TTIs) continue to be a major risk in transfusions in many parts of the world. The transfusion-dependent β-thalassaemia patients are particularly at risk of acquiring TTIs. The current study was undertaken to estimate the prevalence of TTIs in transfusion-dependent β-thalassaemia patients. Material and Methods. A cross-sectional study of 1253 multitransfused thalassaemia major patients was conducted in five different centres of Islamabad, Rawalpindi, and Karachi. The study subjects were screened for HIV, HCV, and HBV. The screening was performed at two centres: Department of Pathology, Shaheed Zulfiqar Ali Bhutto (SZAB) Medical University, and Blood Transfusion Services, Jinnah Postgraduate Medical Centre, from July to December 2015. The confirmatory screening was performed by Chemiluminescent Immunoassay (CLIA). Results. Out of the 1253 multiple transfused patients, 317 (25.3%) were infected with TTIs. HCV was positive in 273 cases (21.7%), HBV in 38 cases (3.0%), and HIV in 6 cases (0.5%). Conclusion. HCV was the leading TTI in multitransfused thalassaemia major patients in the study. Presence of HIV in thalassaemia patients is a recent disturbing development in Pakistan. Improved regulation of blood banks including use of internationally or nationally evaluated kits will bring down the incidence of TTIs in transfusion-dependent β-thalassaemia patients. More stringent behavioral and serological pretransfusion screening of blood for TTIs must be implemented in blood banks. PMID:27559490

  12. Railroad system of Texas: A component of the state and national transportation infrastructure. Research report, September 1996--November 1998

    SciTech Connect

    Roop, S.S.; Warner, J.E.; Rosa, D.; Dickinson, R.W.

    1998-11-01

    Railroads continue to play an important role in the Texas transportation system. This study addresses the potential for implementing a rail planning process in the Texas Department of Transportation. The study is documented in three reports, produced in coordinated and parallel efforts by the Center for Transportation Research and the Texas Transportation Institute. This report documents the work performed by TTI, whereby a rail planning framework is presented which formalizes the planning process and presents the key elements as a series of discrete and logical steps. These steps may be used to guide TxDOT in the formation of goals, identification of issues and affected parties, selection of appropriate analytical methodologies, location of data sources, and implementation of results. The report also presents an in-depth discussion of several key issues facing transportation agencies. These include rail line abandonment, intermodal service planning, and urban rail rationalization. A discussion of the Texas rail system covers the Class 1 railroads, shortline railroads, Amtrak, and the Mexican rail system.

  13. Use of quality rapid diagnostic testing for safe blood transfusion in resource-limited settings.

    PubMed

    Mbanya, D

    2013-05-01

    Blood safety in sub-Saharan Africa is jeopardized by multiple and diverse factors, including the predominance of high-risk family/replacement donors and the high prevalence of transfusion-transmissible infections (TTIs). Thus, stringent diagnostic strategies are vital. Western blotting is costly and technically demanding, and nucleic acid testing technologies, which have been reported to reliably reduce the rate of TTI, are not available in resource-limited settings. Therefore, there is a need for reliable and affordable testing alternatives in these settings. Rapid diagnostic testing has been widely adopted in developing countries, but, for effectiveness in blood safety, highly sensitive tests and the strict selection of low-risk blood donors are indispensable. Although the pre-serological window period remains a source of residual risk for transmission of TTIs during blood transfusion, the combination antigen-antibody rapid tests could contribute significantly to shortening the window period. Thus, despite its limitations, rapid diagnostic testing continues to contribute significantly to blood safety, as a cost-effective means of enhancing screening for TTIs and reducing their transmission in resource-limited rural settings. PMID:23464853

  14. Properties of Wheat-Straw Boards with Frw Based on Interface Treatment

    NASA Astrophysics Data System (ADS)

    Zhu, X. D.; Wang, F. H.; Liu, Y.

    This paper explored the effect of MDI, UF and FRW content on the mechanical and fire retardant property of straw based panels with surface alkali liquor processing. In order to manufacture the straw based panel with high quality, low toxic and fire retardant, the interface of wheat-straw was treated with alkaline liquid, and the orthogonal test was carried out to optimize the technical parameters. The conductivity and diffusion coefficient K of the straw material after alkaline liquid treatment increased obviously. This indicated that alkaline liquid treatment improved the surface wet ability of straw, which is helpful for the infiltration of resin. The results of orthogonal test showed that the optimized treating condition was alkaline liquid concentration as 0.4-0.8%, alkaline dosage as 1:2.5-1:4.5, alkalinetreated time as 12h-48 h.The physical and mechanical properties of wheat-straw boards after treated increased remarkably and it could satisfy the national standard. The improvement of the straw surface wet ability is helpful to the forming of chemical bond. Whereas the variance analysis of the fire retardant property of straw based panel showed that TTI, pkHRR and peak value appearance time were not affected by the MDI, UF and FRW content significantly. The results of orthogonal test showed that the optimized processing condition was MDI content as 3%, UF resin content as 6% and the FRW content as 10%.

  15. Genome-Wide Identification of Mitogen-Activated Protein Kinase Gene Family across Fungal Lineage Shows Presence of Novel and Diverse Activation Loop Motifs

    PubMed Central

    Mohanta, Tapan Kumar; Mohanta, Nibedita; Parida, Pratap; Panda, Sujogya Kumar; Ponpandian, Lakshmi Narayanan; Bae, Hanhong

    2016-01-01

    The mitogen-activated protein kinase (MAPK) is characterized by the presence of the T-E-Y, T-D-Y, and T-G-Y motifs in its activation loop region and plays a significant role in regulating diverse cellular responses in eukaryotic organisms. Availability of large-scale genome data in the fungal kingdom encouraged us to identify and analyse the fungal MAPK gene family consisting of 173 fungal species. The analysis of the MAPK gene family resulted in the discovery of several novel activation loop motifs (T-T-Y, T-I-Y, T-N-Y, T-H-Y, T-S-Y, K-G-Y, T-Q-Y, S-E-Y and S-D-Y) in fungal MAPKs. The phylogenetic analysis suggests that fungal MAPKs are non-polymorphic, had evolved from their common ancestors around 1500 million years ago, and are distantly related to plant MAPKs. We are the first to report the presence of nine novel activation loop motifs in fungal MAPKs. The specificity of the activation loop motif plays a significant role in controlling different growth and stress related pathways in fungi. Hence, the presences of these nine novel activation loop motifs in fungi are of special interest. PMID:26918378

  16. Combustion characteristics of bamboo-biochars.

    PubMed

    Liu, Zhijia; Fei, Benhua; Jiang, Zehui; Liu, Xing'e

    2014-09-01

    Combustion characteristics of biomass are very important to directly utilize as an energy resource. Bamboo was carbonized using a XD-1200N muffle furnace in the nitrogen environment and its combustion characteristics were investigated. Results showed that bamboo-biochars had better combustion characteristics compared to bamboo materials, such as a lower content of moisture and volatiles, a higher energy density, HHV and EHC, a lower H/C and O/C ratios and a shorter TTI. Characteristic peak of bamboo-biochars shifted to higher temperature in thermal decomposition process, indicating a more steady-state burning and a higher combustion efficiency. Bamboo-biochars had a low content of S and N, which was helpful to decrease pollutant emissions. A higher content of K and Na was observed in the ash of bamboo-biochars, resulting in slagging, fouling, corrosion and agglomeration. The data from this research will be very helpful to efficiently design and operate its combustion systems. PMID:24971950

  17. Mapping spatial resources with GPS animal telemetry: foraging manatees locate seagrass beds in the Ten Thousand Islands, Florida, USA

    USGS Publications Warehouse

    Slone, Daniel H.; Reid, James P.; Kenworthy, W. Judson

    2013-01-01

    Turbid water conditions make the delineation and characterization of benthic habitats difficult by traditional in situ and remote sensing methods. Here, we develop and validate modeling and sampling methodology for detecting and characterizing seagrass beds by analyzing GPS telemetry records from radio-tagged manatees. Between October 2002 and October 2005, 14 manatees were tracked in the Ten Thousand Islands (TTI) in southwest Florida (USA) using Global Positioning System (GPS) tags. High density manatee use areas were found to occur off each island facing the open, nearshore waters of the Gulf of Mexico. We implemented a spatially stratified random sampling plan and used a camera-based sampling technique to observe and record bottom observations of seagrass and macroalgae presence and abundance. Five species of seagrass were identified in our study area: Halodule wrightii, Thalassia testudinum, Syringodium filiforme, Halophila engelmannii, and Halophila decipiens. A Bayesian model was developed to choose and parameterize a spatial process function that would describe the observed patterns of seagrass and macroalgae. The seagrasses were found in depths <2 m and in the higher manatee use strata, whereas macroalgae was found at moderate densities at all sampled depths and manatee use strata. The manatee spatial data showed a strong association with seagrass beds, a relationship that increased seagrass sampling efficiency. Our camera-based field sampling proved to be effective for assessing seagrass density and spatial coverage under turbid water conditions, and would be an effective monitoring tool to detect changes in seagrass beds.

  18. [The francophone Africa blood transfusion research network: a five-year report].

    PubMed

    Tagny, Claude Tayou; Murphy, Edward L; Lefrère, Jean-Jacques

    2014-03-01

    There has been little blood safety research in sub-Saharan Africa, often consisting of local efforts whose findings had limited impact The "Francophone Africa Transfusion Research Network" was created in May 2007 with the objective of developing common evidence-based blood safety policies that may be adapted to each country's situation. The Group's activities to date have focused mainly on obtaining epidemiological and laboratory data on blood transfusion and on suggesting blood safety strategies, particularly in the field of TTIs. To carry out such research activities, the group works closely with the National Blood Transfusion Services (NBTS), the Regional Blood Transfusion Services (RBTS), the hospital blood banks (HBB) and collection stations. For the first 5years, four research priorities were identified: (i) descriptive studies of the characteristics of francophone African blood donors and blood centers; (ii) estimation of the residual risk of transfusion-transmitted major viral infections; (iii) an analysis of blood donor deferral strategies; and (iv) a description of TTI screening strategies and an external quality assurance system (EQAS) project. During this period, seven projects have been implemented at the national level and published and five multicenter studies were conducted and published. The present review reports the main observations and recommendations from those studies that could improve blood safety statute in Africa. PMID:24360798

  19. DLMS voice data entry

    NASA Astrophysics Data System (ADS)

    Scott, P. B.

    1980-06-01

    This report describes the design, principles of operation, and performance characteristics of an Advanced Development Model of a voice recognition system (VRS) which can serve to input cartographic data to a computer. The completed system has been installed at the Defense Mapping Agency Aerospace Center (DMAAC) at St. Louis, MO, for evaluation and testing. The VRS is intended for use in entering by voice cartographic data to the Digital Landmass System (DLMS) Data Base. It was designed to satisfy the DMAAC product specifications. The software developed for the VRS includes two complete stand-alone programs. Performance tests conducted at TTI disclosed an average system word recognition accuracy of just under 99 percent for five talkers. The recognition tests were conducted by the use of tape recordings. These tape recordings were made during a previous contract involving cartographic data entry. Each person spoke approximately 536 words after uttering five training repetitions. The test results were virtually identical to those obtained during the previous contract.

  20. Using Structural Equation Modeling to Understand Prescription Stimulant Misuse: A Test of the Theory of Triadic Influence

    PubMed Central

    Bavarian, Niloofar; Flay, Brian R.; Ketcham, Patricia L.; Smit, Ellen; Kodama, Cathy; Martin, Melissa; Saltz, Robert F.

    2014-01-01

    Objective To test a theory-driven model of health behavior to predict the illicit use of prescription stimulants (IUPS) among college students. Participants A probability sample of 554 students from one university located in California (response rate = 90.52%). Methods Students completed a paper-based survey developed with guidance from the Theory of Triadic Influence. We first assessed normality of measures and checked for multicollinearity. A single structural equation model of frequency of IUPS in college was then tested using constructs from the theory’s three streams of influence (i.e., intrapersonal, social situation/context, and sociocultural environment) and four levels of causation (i.e., ultimate causes, distal influences, proximal predictors, and immediate precursors). Results Approximately 18% of students reported engaging in IUPS during college, with frequency of use ranging from never to 40 or more times per academic term. The model tested had strong fit and the majority of paths specified within and across streams were significant at the p<.01 level. Additionally, 46% of the variance in IUPS frequency was explained by the tested model. Conclusions Results suggest the utility of the TTI as an integrative model of health behavior, specifically in predicting IUPS, and provide insight on the need for multifaceted prevention and intervention efforts. PMID:24647369

  1. Production of scandium-44m and scandium-44g with deuterons on calcium-44: cross section measurements and production yield calculations

    NASA Astrophysics Data System (ADS)

    Duchemin, C.; Guertin, A.; Haddad, F.; Michel, N.; Métivier, V.

    2015-09-01

    HIGHLIGHTS • Production of Sc-44m, Sc-44g and contaminants. • Experimental values determined using the stacked-foil technique. • Thick-Target production Yield (TTY) calculations. • Comparison with the TALYS code version 1.6. Among the large number of radionuclides of medical interest, Sc-44 is promising for PET imaging. Either the ground-state Sc-44g or the metastable-state Sc-44m can be used for such applications, depending on the molecule used as vector. This study compares the production rates of both Sc-44 states, when protons or deuterons are used as projectiles on an enriched Calcium-44 target. This work presents the first set of data for the deuteron route. The results are compared with the TALYS code. The Thick-Target production Yields of Sc-44m and Sc-44g are calculated and compared with those for the proton route for three different scenarios: the production of Sc-44g for conventional PET imaging, its production for the new 3 γ imaging technique developed at the SUBATECH laboratory and the production of a Sc-44m/Sc-44g in vivo generator for antibody labelling.

  2. Anisotropy in the lowermost mantle: to the limits of ray theory (and beyond)

    NASA Astrophysics Data System (ADS)

    Nowacki, A.; Walker, A.; Wookey, J. M.; Kendall, J. M.

    2013-12-01

    does not perform any file I/O, removing a major bottleneck in the simulations at the scale we require. As a starting case, one step more complicated than radial anisotropy, we model anisotropy in D″ where there is a rotational axis of symmetry taking any orientation relative to the wave propagation direction (termed tilted transverse isotropy, TTI). In ray theory, one can retrieve the orientation of the axis of symmetry using two rays which traverse the region in different directions by measuring the shear wave splitting in each. The fast orientation should directly relate to the apparent orientation of the axis in that direction. A finite frequency approach, however, shows that whilst shear wave splitting is produced for an anisotropic layer ~50 km thick or more at the base of the mantle, the fast orientation does not relate directly to that expected-it may be up to 45° different to the ray-theory prediction. The situation becomes more complicated as the symmetry of the anisotropy is reduced further to orthorhombic. Nonetheless, we propose a simple relation between observed splitting parameters and TTI orientation which enables qualitative predictions to be made without the necessity of very large calculations on HPC machines. In the medium term, this may be enough to make a first step towards taking seismic observables and retrieving the flow in the deep mantle.

  3. Seismic wavefield propagation in 2D anisotropic media: Ray theory versus wave-equation simulation

    NASA Astrophysics Data System (ADS)

    Bai, Chao-ying; Hu, Guang-yi; Zhang, Yan-teng; Li, Zhong-sheng

    2014-05-01

    Despite the ray theory that is based on the high frequency assumption of the elastic wave-equation, the ray theory and the wave-equation simulation methods should be mutually proof of each other and hence jointly developed, but in fact parallel independent progressively. For this reason, in this paper we try an alternative way to mutually verify and test the computational accuracy and the solution correctness of both the ray theory (the multistage irregular shortest-path method) and the wave-equation simulation method (both the staggered finite difference method and the pseudo-spectral method) in anisotropic VTI and TTI media. Through the analysis and comparison of wavefield snapshot, common source gather profile and synthetic seismogram, it is able not only to verify the accuracy and correctness of each of the methods at least for kinematic features, but also to thoroughly understand the kinematic and dynamic features of the wave propagation in anisotropic media. The results show that both the staggered finite difference method and the pseudo-spectral method are able to yield the same results even for complex anisotropic media (such as a fault model); the multistage irregular shortest-path method is capable of predicting similar kinematic features as the wave-equation simulation method does, which can be used to mutually test each other for methodology accuracy and solution correctness. In addition, with the aid of the ray tracing results, it is easy to identify the multi-phases (or multiples) in the wavefield snapshot, common source point gather seismic section and synthetic seismogram predicted by the wave-equation simulation method, which is a key issue for later seismic application.

  4. LANL receiver system development

    SciTech Connect

    Laubscher, B.; Cooke, B.; Cafferty, M.; Olivas, N.

    1997-08-01

    The CALIOPE receiver system development at LANL is the story of two technologies. The first of these technologies consists of off-the-shelf mercury-cadmium-telluride (MCT) detectors and amplifiers. The vendor for this system is Kolmar Technologies. This system was fielded in the Tan Trailer I (TTI) in 1995 and will be referred to in this paper as GEN I. The second system consists of a MCT detector procured from Santa Barbara Research Center (SBRC) and an amplifier designed and built by LANL. This system was fielded in the Tan Trailer II (TTII) system at the NTS tests in 1996 and will be referred to as GEN II. The LANL CALIOPE experimental plan for 1996 was to improve the lidar system by progressing to a higher rep rate laser to perform many shots in a much shorter period of time. In keeping with this plan, the receiver team set a goal of developing a detector system that was background limited for the projected 100 nanosecond (ns) laser pulse. A set of detailed simulations of the DIAL lidar experiment was performed. From these runs, parameters such as optimal detector size, field of view of the receiver system, nominal laser return power, etc. were extracted. With this information, detector physics and amplifier electronic models were developed to obtain the required specifications for each of these components. These derived specs indicated that a substantial improvement over commercially available, off-the-shelf, amplifier and detector technologies would be needed to obtain the goals. To determine if the original GEN I detector was usable, the authors performed tests on a 100 micron square detector at cryogenic temperatures. The results of this test and others convinced them that an advanced detector was required. Eventually, a suitable detector was identified and a number of these single element detectors were procured from SBRC. These single element detectors were witness for the detector arrays built for another DOE project.

  5. Macroscopic and microscopic evaluation of a new implant design supporting immediately loaded full arch rehabilitation

    PubMed Central

    Tetè, Stefano; Zizzari, Vincenzo; De Carlo, Alessandro; Sinjari, Bruna; Gherlone, Enrico

    2012-01-01

    Summary The purpose of this study is to evaluate macroscopic and microscopic appearance of a new implant design, with particular emphasis given to the type of prosthesis connection. Two dental implants of the same type (Torque Type®, WinSix®, BioSAFin. S.r.l. - Ancona, Italy), with sandblasted and acid etched surfaces (Micro Rough Surface®), but differing from each other for the prosthesis connection system, were examined by scanning electron microscope (SEM) analysis at different magnifications: TTI implant, with a hexagonal internal connection, and TTX implant, with a hexagonal external connection. SEM analysis showed that the Torque Type® implant is characterized by a truncated cone shape with tapered tips. The implant body showed a double loop thread and double pitch with blunt tips. For both types of connection, the implant neck was 0.7 mm in height with a 3% taper. This implant design may be able to guarantee osteotomic properties at the time of insertion in a surgical site suitably prepared, a facilitated screwing, thanks to the thread pitch and to the broad and deep draining grooves, thereby ensuring a good primary stability. The different connection design appears defined and precise, in order to ensure a good interface between the fixture and the prosthetic components. Therefore, this design appears to be particularly suitable in cases where a good primary stability is necessary and a precise coupling between endosseous and prosthetic components, as it allows an easy insertion of the fixture even in conditions of reduced bone availability, and in cases of immediately loaded full-arch rehabilitations. PMID:23087785

  6. Development of blood transfusion product pathogen reduction treatments: a review of methods, current applications and demands.

    PubMed

    Salunkhe, Vishal; van der Meer, Pieter F; de Korte, Dirk; Seghatchian, Jerard; Gutiérrez, Laura

    2015-02-01

    Transfusion-transmitted infections (TTI) have been greatly reduced in numbers due to the strict donor selection and screening procedures, i.e. the availability of technologies to test donors for endemic infections, and routine vigilance of regulatory authorities in every step of the blood supply chain (collection, processing and storage). However, safety improvement is still a matter of concern because infection zero-risk in transfusion medicine is non-existent. Alternatives are required to assure the safety of the transfusion product and to provide a substitution to systematic blood screening tests, especially in less-developed countries or at the war-field. Furthermore, the increasing mobility of the population due to traveling poses a new challenge in the endemic screening tests routinely used, because non-endemic pathogens might emerge in a specific population. Pathogen reduction treatments sum a plethora of active approaches to eliminate or reduce potential threatening pathogen load from blood transfusion products. Despite the success of pathogen reduction treatments applied to plasma products, there is still a long way to develop and deploy pathogen reduction treatments to cellular transfusion products (such as platelets, RBCs or even to whole blood) and there is divergence on its acceptance worldwide. While the use of pathogen reduction treatments in platelets is performed routinely in a fair number of European blood banks, most of these treatments are not (or just) licensed in the USA or elsewhere in the world. The development of pathogen reduction treatments for RBC and whole blood is still in its infancy and under clinical trials. In this review, we discuss the available and emerging pathogen reduction treatments and their advantages and disadvantages. Furthermore, we highlight the importance of characterizing standard transfusion products with current and emerging approaches (OMICS) and clinical outcome, and integrating this information on a database

  7. Geology and habitat of oil in Ras Budran field, Gulf of Suez, Egypt

    SciTech Connect

    Chowdhary, L.R.; Taha, S.

    1987-10-01

    The Ras Budran structure at the deepest mappable seismic reflector, the top of the Kareem Formation (middle Miocene), is a broad northeast-southwest-trending anticlinal feature with an anomalous strike nearly at right angles to the main Gulf of Suez trend. Oil is produced from three units of Nubian Formation sandstone from a depth of 11,000-12,000 ft (3352-3657 m). The lower unit of Paleozoic age averages 10% porosity and has up to 200 md in-situ permeability. Wells completed in this unit produce up to 2000 BOPD. In contrast, the sands to the upper two units of the Early Cretaceous have 15-20% porosity and up to 700 md permeability. Wells completed in this unit produce 6000-8000 BOPD. The Ras Budran structure was formed primarily during an intra-Rudeis tectonic phase (lower Miocene). Oil migration for accumulation in the structure started in the late Miocene or Pliocene when the Santonian Brown Limestone and the Eocene Thebes Formation, the main source beds in the Gulf of Suez, reached the threshold of oil generation at a burial depth of approximately 10,000 ft (3048 m). At this depth, the organic matter in the source beds had a high transformation ratio (0.10 to 0.15), high yields of C/sub 15+/ soluble organic matter and C/sub 15+/ saturated hydrocarbons, vitrinite reflectance (R/sub 0/) of 0.62%, and a time-temperature index (TTI) value of 15. Oil migration from mature source beds in adjoining lows into low-potential Nubian reservoirs is easily explained by fault planes that acted as conduits for oil migration. 16 figures, 3 tables.

  8. Impact of grey zone sample testing by enzyme-linked immunosorbent assay in enhancing blood safety: Experience at a tertiary care hospital in North India

    PubMed Central

    Solanki, Archana; Singh, Abhay; Chaudhary, Rajendra

    2016-01-01

    Background: Enzyme-linked immunosorbent assay (ELISA) used for screening blood donors for transfusion transmitted infections (TTIs) can sometimes fail to detect blood donors who are recently infected or possessing the low strength of pathogen. Estimation of a grey zone in ELISA testing and repeat testing of grey zone samples can further help in reducing the risks of TTI in countries where nucleic acid amplification testing for TTIs is not feasible. Materials and Methods: Grey zone samples with optical density (OD) lying between cut-off OD and 10% below the cut-off OD (cut-off OD × 0.9) were identified during routine ELISA testing. On performing repeat ELISA testing on grey zone samples in duplicate, the samples showing both OD value below grey zone were marked nonreactive, and samples showing one or both OD value in the grey zone were marked indeterminate. The samples on repeat testing showing one or both OD above cut-off value were marked positive. Results: About 119 samples (77 for hepatitis B virus [HBV], 23 for human immunodeficiency virus [HIV], and 19 for hepatitis C virus [HCV]) were found to be in grey zone. On repeat testing of these samples in duplicate, 70 (58.8%) samples (45 for HBV, 12 for HIV, and 13 for HCV) were found to be reactive. Six (5%) samples (four for HBV, one for HIV, and one for HCV) were found to be indeterminate. Conclusion: Seventy donors initially screened negative, were found out to be potentially infectious on repeat grey zone testing. Thus, estimation of grey zone samples with repeat testing can further enhance the safety of blood transfusion. PMID:27011675

  9. Now You Hear Me, Now You Don't: Eyelid Closures as an Indicator of Auditory Task Disengagement

    PubMed Central

    Ong, Ju Lynn; Asplund, Christopher L.; Chia, Tiffany T. Y.; Chee, Michael W. L.

    2013-01-01

    Study Objectives: Eyelid closures in fatigued individuals signify task disengagement in attention-demanding visual tasks. Here, we studied how varying degrees of eyelid closure predict responses to auditory stimuli depending on whether a participant is well rested or sleep deprived. We also examined time-on-task effects and how more and less vulnerable individuals differed in frequency of eye closures and lapses. Design: Six repetitions of an auditory vigilance task were performed in each of two sessions: rested wakefulness (RW) and total sleep deprivation (TSD) (order counterbalanced). Setting: Sleep laboratory. Participants: Nineteen healthy young adults (mean age: 22 ± 2.8 y; 11 males). Intervention: Approximately 24 h of TSD. Measurements and Results: Eyelid closure was rated on a 9-point scale (1 = fully closed to 9 = fully opened) using video segments time-locked to the auditory event. Eyes-open trials predominated during RW, but different degrees of eye closure were uniformly distributed during TSD. The frequency of lapses (response time > 800 ms or nonresponses) to auditory stimuli increased dramatically with greater degrees of eye closure, but the association was strong only during TSD. There were significant within-run time-on-task effects on eye closure and auditory lapses that were exacerbated by TSD. Participants who had more auditory lapses during TSD (more vulnerable) had greater variability in their eyelid closures. Conclusions: Eyelid closures are a strong predictor of auditory task disengagement in the sleep-deprived state but are less relevant during rested wakefulness. Individuals relatively more impaired in this auditory vigilance task during total sleep deprivation display oculomotor evidence for greater state instability. Citation: Ong JL; Asplund CL; Chia TTY; Chee MWL. Now you hear me, now you don't: eyelid closures as an indicator of auditory task disengagement. SLEEP 2013;36(12):1867-1874. PMID:24293761

  10. Efficient Flame Retardant Thin Films Synthesized by Atmospheric Pressure PECVD through the High Co-deposition Rate of Hexamethyldisiloxane and Triethylphosphate on Polycarbonate and Polyamide-6 Substrates.

    PubMed

    Hilt, Florian; Gherardi, Nicolas; Duday, David; Berné, Aurélien; Choquet, Patrick

    2016-05-18

    An innovative approach to produce high-performance and halogen-free flame-retardant thin films at atmospheric pressure is reported. PDMS-based coatings with embedded dopant-rich polyphosphates are elaborated thanks to a straightforward approach, using an atmospheric pressure dielectric barrier discharge (AP-DBD). Deposition conditions have been tailored to elaborate various thin films that can match the fire performance requirements. Morphology, chemical composition, and structure are investigated, and results show that the coatings performances are increased by taking advantage of the synergistic effect of P and Si flame retardant compounds. More specifically, this study relates the possibility to obtain flame retardant properties on PolyCarbonate and PolyAmide-6 thanks to their covering by a 5 μm thick coating, i.e. very thin films for this field of application, yet quite substantial for plasma processes. Hence, this approach enables deposition of flame retardant coatings onto different polymer substrates, providing a versatile fireproofing solution for different natures of polymer substrates. The presence of an expanded charred layer at the surface acts as a protective barrier limiting heat and mass transfer. This latter retains and consumes a part of the PC or PA-6 degradation byproducts and then minimizes the released flammable gases. It may also insulate the substrate from the flame and limit mass transfers of remaining volatile gases. Moreover, reactions in the condensed phase have also been highlighted despite the relatively thin thickness of the deposited layers. As a result of these phenomena, excellent performances are obtained, illustrated by a decrease of the peak of the heat release rate (pHRR) and an increase of the time to ignition (TTI). PMID:27115773

  11. Martin Marietta, Y-12 Plant Laboratory Partnership Program Plan

    SciTech Connect

    Koger, J.

    1995-02-10

    The Y-12 Plant currently embraces three mission areas; stockpile surveillance, maintaining production capability, and storage of special nuclear materials. The Y-12 Plant also contributes to the nations` economic strength by partnering with industry in deploying technology. This partnering has been supported to a great extent through the Technology Transfer Initiative (TTI) directed by DOE/Defense Programs (DP-14). The Oak Ridge Centers for Manufacturing Technology (ORCMT) was established to draw upon the manufacturing and fabrication capabilities at the Y-12 Plant to coordinate and support collaborative efforts, between DP and the domestic industrial sector, toward the development of technologies which offer mutual benefit to both DOE/DP programs and the private sector. Most of the needed technologies for the ``Factory of the Future`` (FOF) are being pursued as core areas at the Y-12 Plant. As a result, 85% of DP-14 projects already support the FOF. The unique capabilities of ORCMT can be applied to a wide range of manufacturing problems to enhance the capabilities of the US industrial base and its economic outcome. The ORCMT has an important role to play in DOE`s Technology Transfer initiative because its capabilities are focused on applied manufacturing and technology deployment which has a more near-term impact on private sector competitiveness. The Y-12 Plant uses the ORCMT to help maintain its own core competencies for the FOF by challenging its engineers and capabilities with technical problems from industry. Areas of strength at the Y-12 Plant that could impact the FOF include modeling of processes and advanced materials; intelligent inspection systems with standardized operator interfaces, analysis software, and part programming language; electronic transfer of designs and features; existing computer-based concurrent engineering; and knowledge-based forming process.

  12. Evaluation of Time-Temperature Integrators (TTIs) with Microorganism-Entrapped Microbeads Produced Using Homogenization and SPG Membrane Emulsification Techniques.

    PubMed

    Rahman, A T M Mijanur; Lee, Seung Ju; Jung, Seung Won

    2015-12-28

    A comparative study was conducted to evaluate precision and accuracy in controlling the temperature dependence of encapsulated microbial time-temperature integrators (TTIs) developed using two different emulsification techniques. Weissela cibaria CIFP 009 cells, immobilized within 2% Na-alginate gel microbeads using homogenization (5,000, 7,000, and 10,000 rpm) and Shirasu porous glass (SPG) membrane technologies (10 μm), were applied to microbial TTIs. The prepared micobeads were characterized with respect to their size, size distribution, shape and morphology, entrapment efficiency, and bead production yield. Additionally, fermentation process parameters including growth rate were investigated. The TTI responses (changes in pH and titratable acidity (TA)) were evaluated as a function of temperature (20°C, 25°C, and 30°C). In comparison with conventional methods, SPG membrane technology was able not only to produce highly uniform, small-sized beads with the narrowest size distribution, but also the bead production yield was found to be nearly 3.0 to 4.5 times higher. However, among the TTIs produced using the homogenization technique, poor linearity (R(2)) in terms of TA was observed for the 5,000 and 7,000 rpm treatments. Consequently, microbeads produced by the SPG membrane and by homogenization at 10,000 rpm were selected for adjusting the temperature dependence. The Ea values of TTIs containing 0.5, 1.0, and 1.5 g microbeads, prepared by SPG membrane and conventional methods, were estimated to be 86.0, 83.5, and 76.6 kJ/mol, and 85.5, 73.5, and 62.2 kJ/mol, respectively. Therefore, microbial TTIs developed using SPG membrane technology are much more efficient in controlling temperature dependence. PMID:26370796

  13. Evolution of oil-generative window (OGW) in Niger delta basin

    SciTech Connect

    Ejedawe, J.E.; Coker, S.J.L.; Lambert-Aikhionbare, D.O.; Alofe, K.B.; Adoh, F.O.

    1983-03-01

    Assuming a simple model of delta development involving progradation and uniform subsidence to present depths (rate, 500 m/m.y.; 1640 ft/m.y.), oil-genesis nomographs derived from the TTI method were constructed for various geothermal gradients of the Niger delta (2.2., 2.5., 2.9, 3.6, 4.0, 4.4, and 4.7/sup 0/C/100 m) and utilized in mapping the positions (depth, temperature) of the top of the oil-generative window (OGW) at arbitrarily selected times (40 m.y.B.P., 30 m.y.B.P., 15 m.y.B.P., and the present). About 200 data points were evaluated. During the active subsidence phase, oil generation within any megastructure was initiated at a temperature of 140 to 146/sup 0/C (284 to 294/sup 0/F) and depth of 3000 to 5200 m (9842 to 17,060 ft) within 7 to 11 m.y. after deposition of the potential source rocks. After cessation of subsidence, upward movement of the OGW by 800 to 1600 m (2624 to 5249 ft) was accompanied by a temperature lowering of 23 to 54/sup 0/C (73 to 129/sup 0/F). Lower temperatures produced correspondingly heavier crudes. In some parts of the delta oil generation and expulsion from the lower part of the Agbada Formation predates the cessation of subsidence and structural deformation, while in others it postdates those events. In most parts of the Niger delta, the upper and normally compacted part of the Akata Formation appears to constitute the major source rock.

  14. Initial Results from the Miniature Imager for Neutral Ionospheric Atoms and Magnetospheric Electrons (MINI-ME) on the FASTSAT Spacecraft

    NASA Technical Reports Server (NTRS)

    Collier, Michael R.; Rowland, Douglas; Keller, John W.; Chornay, Dennis; Khazanov, George; Herrero, Federico; Moore, Thomas E.; Kujawski, Joseph; Casas, Joseph C.; Wilson, Gordon

    2011-01-01

    The MINI-ME instrument is a collaborative effort between NASA's Goddard Space Flight Center (GSFC) and the U.S. Naval Academy, funded solely through GSFC Internal Research and Development (IRAD) awards. It detects neutral atoms from about 10 eV to about 700 eV (in 30 energy steps) in its current operating configuration with an approximately 10 degree by 360 degree field-of-view, divided into six sectors. The instrument was delivered on August 3, 2009 to Marshall Space Flight Center (MSFC) for integration with the FASTSAT-HSV01 small spacecraft bus developed by MSFC and a commercial partner, one of six Space Experiment Review Board (SERB) experiments on FASTSAT and one of three GSFC instruments (PISA and TTI being the other two). The FASTSAT spacecraft was launched on November 21, 2010 from Kodiak, Alaska on a Minotaur IV as a secondary payload and inserted into a 650 km, 72 degree inclination orbit, very nearly circular. MINI-ME has been collecting science data, as spacecraft resources would permit, in "optimal science mode" since January 20, 2011. In this presentation, we report initial science results including the potential first observations of neutral molecular ionospheric outflow. At the time of this abstract, we have identified 15 possible molecular outflow events. All these events occur between about 65 and 82 degrees geomagnetic latitude and most map to the auroral oval. The MINI-ME results provide an excellent framework for interpretation of the MILENA data, two instruments almost identical to MINI-ME that will launch on the VISIONS suborbital mission

  15. Behavior and Release of Nitrogen at Mines and Quarries in Nordic Conditions

    NASA Astrophysics Data System (ADS)

    Karlsson, Teemu; Neitola, Raisa; Jermakka, Johannes; Merta, Elina; Mroueh, Ulla-Maija

    2015-04-01

    project with GTK, VTT and TTY together with several industrial and international partners and financed by Tekes Green Mining Programme.

  16. The external quality assessment scheme: Five years experience as a participating laboratory

    PubMed Central

    Chaudhary, Rajendra; Das, Sudipta S.; Ojha, Shashank; Khetan, Dheeraj; Sonker, Atul

    2010-01-01

    Background and Aim: Quality assurance in blood banking includes active participation in the external quality program. Such a program offers valuable benefits to patient care, their safety, and an overall quality of laboratory practices. In the year 2002, we participated in the External Quality Assessment Scheme (EQAS) under the World Health Organization (WHO), Bureau of Laboratory Quality Standards, Thailand. Materials and Methods: In the current study we evaluated our EQAS test result of the past five years, from 2003 to 2007. Test results of all blood samples such as ABO grouping, D typing, antibody screening, antibody identification, and transfusion transmitted infection (TTI) testing were analyzed and documented. Results: Discordant results in one or more instances were observed with antibody identification, weak D testing, and tests for anti-HIV1/2 and HBsAg. Twice we failed to detect the ‘anti-Mia’ antibody in the issued sample and that could be attributed to the absence of the corresponding antigen in the used cell panel. HBsAg was missed due to its critically low titer in the serum and the comparatively low sensitivity of our Enzyme-Linked Immunosorbent Assay (ELISA) test kit. Conclusion: All these failures in the last five years have helped us to significantly improve our transfusion service in terms of performance evaluation, patient care and safety issues, and the overall quality of laboratory practices. We therefore recommend all laboratories and hospitals to participate in the EQAS program, which will definitely help them to improve from what they learn. PMID:20376263

  17. Nucleic acid testing: Is it the only answer for safe Blood in India?

    PubMed Central

    Naidu, N. K.; Bharucha, Z. S.; Sonawane, Vandana; Ahmed, Imran

    2016-01-01

    Background: With the implementation of NAT in countries around the world, there is a growing pressure on the transfusion services in India to adopt NAT testing. India has about 2545 licensed Blood Centres. The Transfusion Services in India are fragmented, poorly regulated and the quality standards are poorly implemented. Blood Centres are still dependent on replacement/family donors and in most places laboratory testing for Transfusion transmitted infections is not quality assured, laboratory equipment are not calibrated and maintained, and validation of results is not carried out. Against the current scenario introducing NAT for screening of blood donors in India would pose a challenge. Aim: To study the prudence of universal NAT testing in India. Materials and Methods: A retrospective study of 5 years from 2008-2012 was undertaken to study the true reactivity of donors using WHO strategy II and III and therefore the true seroprevalence of TTI infections in the donor populations. Results: The true reactivity of the donors was much less as compared to the initially reactive donors due to the use of a well designed testing algorithm. In addition having a total voluntary blood collection along with good pre-donation counseling program also reduces the transmission of infections. Conclusions: What India essentially needs to do is religiously implement the strategies outlined in the WHO Aide-memoire. The blood should be collected only from voluntary non remunerative and repeat donors, there should be stringent donor selection with pre-donation counseling instituted. Strict implementation of quality management system, development of well defined testing startegies and strong haemovigilance system could take us a step in the right direction. PMID:27011677

  18. [Evaluation of the addition of counterpulsation to the partial left ventricular-femoral bypass for limitation of evolving myocardial infarction].

    PubMed

    Yamaguchi, A; Ide, H; Ino, T; Adachi, H; Mizuhara, A; Kawahito, K; Murata, S

    1994-08-01

    The effect of adding counterpulsation to a partial left ventricular bypass was evaluated in a canine model of acute myocardial ischemia by using a myocardial staining method. To establish a left ventricular bypass, a catheter consisting of bypass tube (90 cm in length and 15 Fr in inner diameter) and an accompanying intraaortic balloon as a single apparatus (Integrated Cardioassist Catheter; ICAC) was introduced into the left ventricle via the abdominal aorta. The left ventricular bypass was adjusted to 1 L/min. with or without counterpulsation with the aid of a centrifugal pump and IABP console. The use of the ICAC that provided pulsatile left ventricular bypass tended to raise the mean aortic pressure and cardiac output. Reduction of the tension time index was noted with the use of the ICAC in contrast to the control. And increment of the DPTI/TTI ratio was observed with the use of the ICAC in contrast to the control and partial left ventricular bypass alone. While the percentages of the region at risk were similar [17.3 +/- 9.5% (control), vs. 16.4 +/- 3.4% (partial left ventricular bypass alone) vs. 16.9 +/- 5.2% (ICAC)], the percentages of infarct sizes were reduced due to the use of counterpulsation. [61.9 +/- 12.2% (control), vs. 57.5 +/- 3.9% (partial left ventricular bypass alone) vs. 16.8 +/- 6.0% (ICAC)]. These results revealed that the addition of counterpulsation alleviates afterload reduction to the partial left ventricular bypass and was more beneficial to the reduction of the infarct size than partial left ventricular bypass alone. PMID:7963829

  19. Seismic imaging in hardrock environments: The role of heterogeneity?

    NASA Astrophysics Data System (ADS)

    Bongajum, Emmanuel; Milkereit, Bernd; Adam, Erick; Meng, Yijian

    2012-10-01

    We investigate the effect of petrophysical scale parameters and structural dips on wave propagation and imaging in heterogeneous media. Seismic wave propagation effects within the heterogeneous media are studied for different velocity models with scale lengths determined via stochastic analysis of petrophysical logs from the Matagami mine, Quebec, Canada. The elastic modeling study reveals that provided certain conditions of the velocity fluctuations are met, strong local distortions of amplitude and arrival times of propagating waves are observed as the degree of scale length anisotropy in the P-wave velocity increases. The location of these local amplitude anomalies is related to the dips characterizing the fabric of the host rocks. This result is different from the elliptical shape of direct waves often defined by effective anisotropic parameters used for layered media. Although estimates of anisotropic parameters suggest weak anisotropy in the investigated models, these effective anisotropic parameters often used in VTI/TTI do not sufficiently describe the effects of scale length anisotropy in heterogeneous media that show such local amplitude, travel time, and phase distortions in the wavefields. Numerical investigations on the implications for reverse time migration (RTM) routines corroborate that mean P-wave velocity of the host rocks produces reliable imaging results. Based on the RTM results, we postulate the following: weak anisotropy in hardrock environments is a sufficient assumption for processing seismic data; and seismic scattering effects due to velocity heterogeneity with a dip component is not sufficient to cause mislocation errors of target structures as observed in the discrepancy between the location of the strong seismic reflections associated to the Matagami sulfide orebody and its true location. Future work will investigate other factors that may provide plausible explanations for these mislocation problems, with the objective of providing a

  20. Namibia’s transition from whole blood–derived pooled platelets to single-donor apheresis platelet collections

    PubMed Central

    Pitman, John P.; Basavaraju, Sridhar V.; Shiraishi, Ray W.; Wilkinson, Robert; von Finckenstein, Bjorn; Lowrance, David W.; Marfin, Anthony A.; Postma, Maarten; Mataranyika, Mary; Sibinga, Cees Th. Smit

    2015-01-01

    BACKGROUND Few African countries separate blood donations into components; however, demand for platelets (PLTs) is increasing as regional capacity to treat causes of thrombocytopenia, including chemotherapy, increases. Namibia introduced single-donor apheresis PLT collections in 2007 to increase PLT availability while reducing exposure to multiple donors via pooling. This study describes the impact this transition had on PLT availability and safety in Namibia. STUDY DESIGN AND METHODS Annual national blood collections and PLT units issued data were extracted from a database maintained by the Blood Transfusion Service of Namibia (NAMBTS). Production costs and unit prices were analyzed. RESULTS In 2006, NAMBTS issued 771 single and pooled PLT doses from 3054 whole blood (WB) donations (drawn from 18,422 WB donations). In 2007, NAMBTS issued 486 single and pooled PLT doses from 1477 WB donations (drawn from 18,309 WB donations) and 131 single-donor PLT doses. By 2011, NAMBTS issued 837 single-donor PLT doses per year, 99.1% of all PLT units. Of 5761 WB donations from which PLTs were made in 2006 to 2011, a total of 20 (0.35%) were from donors with confirmed test results for human immunodeficiency virus or other transfusion-transmissible infections (TTIs). Of 2315 single-donor apheresis donations between 2007 and 2011, none of the 663 donors had a confirmed positive result for any pathogen. As apheresis replaced WB-derived PLTs, apheresis production costs dropped by a mean of 8.2% per year, while pooled PLT costs increased by an annual mean of 21.5%. Unit prices paid for apheresis- and WB-derived PLTs increased by 9 and 7.4% per year on average, respectively. CONCLUSION Namibia’s PLT transition shows that collections from repeat apheresis donors can reduce TTI risk and production costs. PMID:25727921

  1. Basin analysis of South Mozambique graben

    SciTech Connect

    Iliffe, J.; Lerche, I.; De Buyl, M.

    1987-05-01

    Basin analysis of the South Mozambique graben between latitudes 25/sup 0/ and 26/sup 0/ and longitudes 34/sup 0/ and 35/sup 0/ demonstrates how modeling techniques may help to assess the oil potential of a speculative basin with only minimal seismic data. Two-dimensional restoration of the seismic profiles, using a backstripping and decompaction program on pseudowells linked with structural reconstruction, assesses the rift's two-phase extensional history. Since no well or thermal indicator data exist within the basin, the thermal history had to be derived from extensional models. The best fit of observed subsidence curves and those predicted by the models results in values of lithospheric extension (gamma). The disagreement in observed and theoretical basement subsidence curves was minimized by taking a range of gamma for each model for each well. These extension factors were then used in each model's equations for paleoheat flux to derive the heat-flow histories. (It is noted that a systematic basinwide variance of gamma occurs.) The heat-flux histories were then used with a one-dimensional fluid flow/compaction model to calculate TTI values and oil windows. A Tissot generation model was applied to each formation in every well for kerogen Types I, II, and III. The results were contoured across the basin to assess possible oil- and gas-prone formations. The extensional, burial, and thermal histories are integrated into an overall basin development picture and provide an oil and gas provenance model. Thus they estimate the basinwide hydrocarbon potential and also gain insight into the additional data necessary to significantly decrease the uncertainty.

  2. Tumor Touch Imprints as Source for Whole Genome Analysis of Neuroblastoma Tumors

    PubMed Central

    Brunner, Clemens; Brunner-Herglotz, Bettina; Ziegler, Andrea; Frech, Christian; Amann, Gabriele; Ladenstein, Ruth; Ambros, Inge M.; Ambros, Peter F.

    2016-01-01

    Introduction Tumor touch imprints (TTIs) are routinely used for the molecular diagnosis of neuroblastomas by interphase fluorescence in-situ hybridization (I-FISH). However, in order to facilitate a comprehensive, up-to-date molecular diagnosis of neuroblastomas and to identify new markers to refine risk and therapy stratification methods, whole genome approaches are needed. We examined the applicability of an ultra-high density SNP array platform that identifies copy number changes of varying sizes down to a few exons for the detection of genomic changes in tumor DNA extracted from TTIs. Material and Methods DNAs were extracted from TTIs of 46 neuroblastoma and 4 other pediatric tumors. The DNAs were analyzed on the Cytoscan HD SNP array platform to evaluate numerical and structural genomic aberrations. The quality of the data obtained from TTIs was compared to that from randomly chosen fresh or fresh frozen solid tumors (n = 212) and I-FISH validation was performed. Results SNP array profiles were obtained from 48 (out of 50) TTI DNAs of which 47 showed genomic aberrations. The high marker density allowed for single gene analysis, e.g. loss of nine exons in the ATRX gene and the visualization of chromothripsis. Data quality was comparable to fresh or fresh frozen tumor SNP profiles. SNP array results were confirmed by I-FISH. Conclusion TTIs are an excellent source for SNP array processing with the advantage of simple handling, distribution and storage of tumor tissue on glass slides. The minimal amount of tumor tissue needed to analyze whole genomes makes TTIs an economic surrogate source in the molecular diagnostic work up of tumor samples. PMID:27560999

  3. Estimation of carbon dioxide emissions per urban center link unit using data collected by the Advanced Traffic Information System in Daejeon, Korea

    NASA Astrophysics Data System (ADS)

    Ryu, B. Y.; Jung, H. J.; Bae, S. H.; Choi, C. U.

    2013-12-01

    CO2 emissions on roads in urban centers substantially affect global warming. It is important to quantify CO2 emissions in terms of the link unit in order to reduce these emissions on the roads. Therefore, in this study, we utilized real-time traffic data and attempted to develop a methodology for estimating CO2 emissions per link unit. Because of the recent development of the vehicle-to-infrastructure (V2I) communication technology, data from probe vehicles (PVs) can be collected and speed per link unit can be calculated. Among the existing emission calculation methodologies, mesoscale modeling, which is a representative modeling measurement technique, requires speed and traffic data per link unit. As it is not feasible to install fixed detectors at every link for traffic data collection, in this study, we developed a model for traffic volume estimation by utilizing the number of PVs that can be additionally collected when the PV data are collected. Multiple linear regression and an artificial neural network (ANN) were used for estimating the traffic volume. The independent variables and input data for each model are the number of PVs, travel time index (TTI), the number of lanes, and time slots. The result from the traffic volume estimate model shows that the mean absolute percentage error (MAPE) of the ANN is 18.67%, thus proving that it is more effective. The ANN-based traffic volume estimation served as the basis for the calculation of emissions per link unit. The daily average emissions for Daejeon, where this study was based, were 2210.19 ton/day. By vehicle type, passenger cars accounted for 71.28% of the total emissions. By road, Gyeryongro emitted 125.48 ton/day, accounting for 5.68% of the total emission, the highest percentage of all roads. In terms of emissions per kilometer, Hanbatdaero had the highest emission volume, with 7.26 ton/day/km on average. This study proves that real-time traffic data allow an emissions estimate in terms of the link unit

  4. Orotracheal intubation of morbidly obese patients, comparison of GlideScope® video laryngoscope and the LMA CTrach™ with direct laryngoscopy

    PubMed Central

    Yousef, Gamal T.; Abdalgalil, Dief A.; Ibrahim, Tamer H.

    2012-01-01

    Background: Morbidly obese patients are at increased risk of difficult mask ventilation and intubation as well as increased risk of hypoxemia during tracheal intubation. Recently, new video-assisted intubation devices have been developed. The GlideScope® videolaryngoscope and LMA CTrach™ (CT) allows continuous video-endoscopy of the tracheal intubation procedure. Objective: this study is to determine whether the GlideScope® videolaryngoscope (GVL) and the LMA CTrach™ (CT) provide the best airway management, measured primarily in intubation difficulty scale (IDS) scores, time and numbers of intubation attempts, and improvement in the intubation success rate of morbidly obese patients when compared with the direct Macintosh laryngoscope (DL). Materials and Methods: After Ethics’ Committee approval, 90 morbidly obese patients (BMI > 35 kg/m2) scheduled for general, gynecological, and bariatric surgery were included in this prospective study. Patients were randomly assigned in three groups: tracheal intubation using direct laryngoscopy (DL), GlideScope® videolaryngoscope (GVL) or the LMA CTrach™ (CT). Characteristics and consequences of airway management were evaluated. The primary outcome was the intubation difficulty scale score (IDS), Secondary outcomes were theintubation time, overall success rate, number of attempts, Cormack–Lehane grade, subjective difficulty of intubation, desaturation and upper airway morbidity. Results: Difficulty in facemask ventilation was similar in the three groups. IDS scores were significantly lower with GVL and CT than with DL. The mean TTI was 14 s faster in patients intubated with the GVL (86 s, IQR: 68-115) compared with DL (100 s, IQR; 80-150), and was 34 s faster when compared with CT (120 s, IQR; 95-180). The success rate of tracheal intubation was lower with the DL (80%) compared with the GVL (100%) or the CT (100%). Six cases of failed intubation occurred in group DL, four patients from the six patients were

  5. Hybrid FES-robot cooperative control of ambulatory gait rehabilitation exoskeleton.

    PubMed

    del-Ama, Antonio J; Gil-Agudo, Angel; Pons, José L; Moreno, Juan C

    2014-01-01

    stimulation; HKAFO: hip-knee-ankle-foot orthosis; ILC: iterative error-based learning control; MFE: muscle fatigue estimator; NILC: Normalized stimulation output from ILC controller; PID: Proportional-Integral-derivative Control; PW: Stimulation pulse width; QUEST: Quebec User Evaluation of Satisfaction with assistive Technology; SCI: Spinal cord injury; TTI: torque-time integral; VAS: Visual Analog Scale. PMID:24594302

  6. Geology and habitat of oil in Ras Budran field, Gulf of Suez, Egypt

    SciTech Connect

    Chowdhary, L.R.; Taha, S.

    1987-05-01

    Deminex discovered the Ras Budran oil field in 1978. Discovery well EE 85-1 was drilled in about 140 ft of water, 4 km off the Sinai coast of the Gulf of Suez. Appraisal drilling (EE 85-2, 3, and 4 wells) confirmed the presence of a major field with an estimated 700 million bbl oil in place. The field, developed from three wellhead platforms, went on production in April 1983. To date, 20 development wells have been drilled. The Ras Budran structure at the deepest mappable seismic reflector, top Kareem (middle Miocene), is a broad northeast-southwest-trending anticlinal feature striking nearly at right angles to the main Gulf of Suez trend. At pre-Miocene producing horizons, the structure is complex and consists of a northeast-dipping flank (14-15) broken into several blocks by faults and limited to the south and west by major bounding faults. Oil is produced from three units of Nubian sandstone at a depth of 11,000 to 12,000 ft. The lower unit of Paleozoic age averages 10% porosity and up to 200 md in -situ permeability. The wells completed in this unit produce up to 2000 BOPD. In contrast, the sands of the upper two units of Lower Cretaceous age have a 15-20% porosity and up to 700 md permeability. The wells completed in these units produce 6000-8000 BOPD. The Ras Budran structure was primarily formed during the intra-Rudeis tectonic phase (lower Miocene). Migration of oil for accumulation in Ras Budran started late in the upper Miocene or Pliocene when the Santonian Brown Limestone and the Eocene Thebes Formation, the main source beds in the Gulf, reached the threshold of oil generation at a burial depth of about 10,000 ft (3000 m). At these depths, the organic matter in the source beds have a transformation ratio (0.10 to 0.15), increased yields of C15 + soluble organic matter and C15 + saturated hydrocarbons, a vitrinite reflectance of 0.62%, and a TTI value of 15.

  7. Isoprene chemistry in pristine and polluted Amazon environments: Eulerian and Lagrangian model frameworks and the strong bearing they have on our understanding of surface ozone and predictions of rainforest exposure to this priority pollutant

    NASA Astrophysics Data System (ADS)

    Levine, J. G.; MacKenzie, A. R.; Squire, O. J.; Archibald, A. T.; Griffiths, P. T.; Abraham, N. L.; Pyle, J. A.; Oram, D. E.; Forster, G.; Brito, J. F.; Lee, J. D.; Hopkins, J. R.; Lewis, A. C.; Bauguitte, S. J. B.; Demarco, C. F.; Artaxo, P.; Messina, P.; Lathière, J.; Hauglustaine, D. A.; House, E.; Hewitt, C. N.; Nemitz, E.

    2015-09-01

    This study explores our ability to simulate the atmospheric chemistry stemming from isoprene emissions in pristine and polluted regions of the Amazon basin. We confront two atmospheric chemistry models - a global, Eulerian chemistry-climate model (UM-UKCA) and a trajectory-based Lagrangian model (CiTTyCAT) - with recent airborne measurements of atmospheric composition above the Amazon made during the SAMBBA campaign of 2012. The simulations with the two models prove relatively insensitive to the chemical mechanism employed; we explore one based on the Mainz Isoprene Mechanism, and an updated one that includes changes to the chemistry of first generation isoprene nitrates (ISON) and the regeneration of hydroxyl radicals via the formation of hydroperoxy-aldehydes (HPALDS) from hydroperoxy radicals (ISO2). In the Lagrangian model, the impact of increasing the spatial resolution of trace gas emissions employed from 3.75° × 2.5° to 0.1° × 0.1° varies from one flight to another, and from one chemical species to another. What consistently proves highly influential on our simulations, however, is the model framework itself - how the treatment of transport, and consequently mixing, differs between the two models. The lack of explicit mixing in the Lagrangian model yields variability in atmospheric composition more reminiscent of that exhibited by the measurements. In contrast, the combination of explicit (and implicit) mixing in the Eulerian model removes much of this variability but yields better agreement with the measurements overall. We therefore explore a simple treatment of mixing in the Lagrangian model that, drawing on output from the Eulerian model, offers a compromise between the two models. We use this Lagrangian/Eulerian combination, in addition to the separate Eulerian and Lagrangian models, to simulate ozone at a site in the boundary layer downwind of Manaus, Brazil. The Lagrangian/Eulerian combination predicts a value for an AOT40-like accumulated

  8. Anisotropy effects on 3D waveform inversion

    NASA Astrophysics Data System (ADS)

    Stekl, I.; Warner, M.; Umpleby, A.

    2010-12-01

    In the recent years 3D waveform inversion has become achievable procedure for seismic data processing. A number of datasets has been inverted and presented (Warner el al 2008, Ben Hadj at all, Sirgue et all 2010) using isotropic 3D waveform inversion. However the question arises will the results be affected by isotropic assumption. Full-wavefield inversion techniques seek to match field data, wiggle-for-wiggle, to synthetic data generated by a high-resolution model of the sub-surface. In this endeavour, correctly matching the travel times of the principal arrivals is a necessary minimal requirement. In many, perhaps most, long-offset and wide-azimuth datasets, it is necessary to introduce some form of p-wave velocity anisotropy to match the travel times successfully. If this anisotropy is not also incorporated into the wavefield inversion, then results from the inversion will necessarily be compromised. We have incorporated anisotropy into our 3D wavefield tomography codes, characterised as spatially varying transverse isotropy with a tilted axis of symmetry - TTI anisotropy. This enhancement approximately doubles both the run time and the memory requirements of the code. We show that neglect of anisotropy can lead to significant artefacts in the recovered velocity models. We will present inversion results of inverting anisotropic 3D dataset by assuming isotropic earth and compare them with anisotropic inversion result. As a test case Marmousi model extended to 3D with no velocity variation in third direction and with added spatially varying anisotropy is used. Acquisition geometry is assumed as OBC with sources and receivers everywhere at the surface. We attempted inversion using both 2D and full 3D acquisition for this dataset. Results show that if no anisotropy is taken into account although image looks plausible most features are miss positioned in depth and space, even for relatively low anisotropy, which leads to incorrect result. This may lead to

  9. Anisotropy in the lowermost mantle beneath the circum-Pacific: observations and modelling

    NASA Astrophysics Data System (ADS)

    Walpole, J.; Wookey, J. M.; Nowacki, A.; Walker, A.; Kendall, J. M.; Masters, G.; Forte, A. M.

    2014-12-01

    The lowermost 300 km of mantle (D'') acts as the lower boundary layer to mantle convection. Numerous observations find that this layer is anisotropic, unlike the bulk of the lower mantle above, which is isotropic. The causal mechanism for this anisotropy remains elusive, though its organisation is likely to be imposed by deformation associated with mantle convection. The subduction of the Tethys ocean (since 180 Ma) is predicted to have deposited slab material in D'' in circum-Pacific regions, making these regions cold, encouraging the phase transformation in the MgSiO3 polymorph bridgmanite to a post-perovskite (ppv) structure. These regions are probably rich in ppv. Here we present new observations of anisotropy from shear wave splitting of ScS phases recorded in the epicentral distance range 50-85 degrees. These observations are corrected for anisotropy in the upper mantle beneath source and receiver. Due to the layout of events and receivers we primarily sample D'' beneath the landward side of the circum-Pacific. A detailed pattern of anisotropy is revealed. Anisotropy predominantly leads to SH fast wave propagation with an inferred average strength of 0.9%. This is consistent with many previous observations. However, we do not limit our observations to the SH/SV system. Many observations show non SH/SV fast polarisation. We interpret these data for tilted transverse isotropy (TTI) style anisotropy. We resolve non-radial anisotropy at unprecedented global scale, in turn placing new constraints on the D'' flow field. We test the ability of the flow model TX2008 (Simmons et al., 2009) to fit our observations. This is achieved by modelling the development of a lattice preferred orientation texture of a ppv layer subject to this flow field using a visco-plastic self consistent theory (Walker et al., 2011). Due to uncertainty in the slip system of ppv three candidate glide planes are trialled: (100)/{110}, (010), and (001). The seismic anisotropy of these models is

  10. Hybrid FES-robot cooperative control of ambulatory gait rehabilitation exoskeleton

    PubMed Central

    2014-01-01

    stimulation; HKAFO: hip-knee-ankle-foot orthosis; ILC: iterative error-based learning control; MFE: muscle fatigue estimator; NILC: Normalized stimulation output from ILC controller; PID: Proportional-Integral-derivative Control; PW: Stimulation pulse width; QUEST: Quebec User Evaluation of Satisfaction with assistive Technology; SCI: Spinal cord injury; TTI: torque-time integral; VAS: Visual Analog Scale. PMID:24594302

  11. Regional brain heating during microwave exposure (2.06 GHz), warm-water immersion, environmental heating and exercise.

    PubMed

    Walters, T J; Ryan, K L; Belcher, J C; Doyle, J M; Tehrany, M R; Mason, P A

    1998-01-01

    Nonuniform heating may result from microwave (MW) irradiation of tissues and is therefore important to investigate in terms of health and safety issues. Hypothalamic (Thyp), cortical (Tctx), tympanic (Tty), and rectal (Tre) temperatures were measured in rats exposed in the far field, k-polarization (i.e., head pointed toward the transmitter horn and E-field in vertical direction) to two power densities of 2.06 GHz irradiation. The high-power density (HPM) was 1700 mW/cm2 [specific absorption rate (SAR): hypothalamus 1224 W/kg; cortex 493 W/kg]; the low-power density (LPM) was 170 mW/cm2 (SAR: hypothalamus 122.4 W/kg; cortex 49.3 W/kg). The increase (rate-of-rise, in degrees C/s) in Thyp was significantly greater than those in Tctx or Tre when rats were exposed to HPM. LPM produced more homogeneous heating. Quantitatively similar results were observed whether rats were implanted with probes in two brain sites or a single probe in one or the other of the two sites. The qualitative difference between regional brain heating was maintained during unrestrained exposure to HPM in the h-polarization (i.e., body parallel to magnetic field). To compare the temperature changes during MW irradiation with those produced by other modalities of heating, rats were immersed in warm water (44 degrees C, WWI); exposed to a warm ambient environment (50 degrees C, WSED); or exercised on a treadmill (17 m/min 8% grade) in a warm ambient environment (35 degrees C, WEX). WWI produced uniform heating in the regions measured. Similar rates-of-rise occurred among regions following WSED or WEX, thus maintaining the pre-existing gradient between Thyp and Tctx These data indicate that HPM produced a 2-2.5-fold difference in the rate-of-heating within brain regions that were separated by only a few millimeters. In contrast, more homogeneous heating was recorded during LPM or nonmicrowave modalities of heating. PMID:9738525

  12. Modelling component evaporation and composition change of traffic-induced ultrafine particles during travel from street canyon to urban background.

    PubMed

    Nikolova, Irina; MacKenzie, A Rob; Cai, Xiaoming; Alam, Mohammed S; Harrison, Roy M

    2016-07-18

    We developed a model (CiTTy-Street-UFP) of traffic-related particle behaviour in a street canyon and in the nearby downwind urban background that accounts for aerosol dynamics and the variable vapour pressure of component organics. The model simulates the evolution and fate of traffic generated multicomponent ultrafine particles (UFP) composed of a non-volatile core and 17 Semi-Volatile Organic Compounds (SVOC, modelled as n-alkane proxies). A two-stage modelling approach is adopted: (1) a steady state simulation inside the street canyon is achieved, in which there exists a balance between traffic emissions, condensation/evaporation, deposition, coagulation and exchange with the air above roof-level; and (2) a continuing simulation of the above-roof air parcel advected to the nearby urban park during which evaporation is dominant. We evaluate the component evaporation and associated composition changes of multicomponent organic particles in realistic atmospheric conditions and compare our results with observations from London (UK) in a street canyon and an urban park. With plausible input conditions and parameter settings, the model can reproduce, with reasonable fidelity, size distributions in central London in 2007. The modelled nucleation-mode peak diameter, which is 23 nm in the steady-state street canyon, decreases to 9 nm in a travel time of just 120 s. All modelled SVOC in the sub-10 nm particle size range have evaporated leaving behind only non-volatile material, whereas modelled particle composition in the Aitken mode contains SVOC between C26H54 and C32H66. No data on particle composition are available in the study used for validation, or elsewhere. Measurements addressing in detail the size resolved composition of the traffic emitted UFP in the atmosphere are a high priority for future research. Such data would improve the representation of these particles in dispersion models and provide the data essential for model validation. Enhanced knowledge of the

  13. Sedimentary modeling and analysis of petroleum system of the upper Tertiary sequences in southern Ulleung sedimentary Basin, East Sea (Sea of Japan)

    NASA Astrophysics Data System (ADS)

    Cheong, D.; Kim, D.; Kim, Y.

    2010-12-01

    The block 6-1 located in the southwestern margin of the Ulleung basin, East Sea (Sea of Japan) is an area where recently produces commercial natural gas and condensate. A total of 17 exploratory wells have been drilled, and also many seismic explorations have been carried out since early 1970s. Among the wells and seismic sections, the Gorae 1 well and a seismic section through the Gorae 1-2 well were chosen for this simulation work. Then, a 2-D graphic simulation using SEDPAK elucidates the evolution, burial history and diagenesis of the sedimentary sequence. The study area is a suitable place for modeling a petroleum system and evaluating hydrocarbon potential of reservoir. Shale as a source rock is about 3500m deep from sea floor, and sandstones interbedded with thin mud layers are distributed as potential reservoir rocks from 3,500m to 2,000m deep. On top of that, shales cover as seal rocks and overburden rocks upto 900m deep. Input data(sea level, sediment supply, subsidence rate, etc) for the simulation was taken from several previous published papers including the well and seismic data, and the thermal maturity of the sediment was calculated from known thermal gradient data. In this study area, gas and condensate have been found and commercially produced, and the result of the simulation also shows that there is a gas window between 4000m and 6000m deep, so that three possible interpretations can be inferred from the simulation result. First, oil has already moved and gone to the southeastern area along uplifting zones. Or second, oil has never been generated because organic matter is kerogen type 3, and or finally, generated oil has been converted into gas by thermally overcooking. SEDPAK has an advantage that it provides the timing and depth information of generated oil and gas with TTI values even though it has a limit which itself can not perform geochemical modeling to analyze thermal maturity level of source rocks. Based on the result of our simulation

  14. Sediment-pore water interactions controlling cementation in the NanTroSEIZE drilling transects

    NASA Astrophysics Data System (ADS)

    Hong, W.; Spinelli, G. A.; Torres, M. E.

    2012-12-01

    dissolved silicate released from ash alteration precipitates as cement, inhibiting consolidation. At or below the boundary, the increase in pH (>8.0), leads to oversaturation (and precipitation) of clinoptilolite. Strong demand of dissolved silicate due to clinoptilolite formation soon depletes the dissolved potassium and silicate; ash and silicate cement are forced to dissolve. The exact set of reactions resulting on the observed pH increase is still unclear, but it likely involves the carbon system. It is noteworthy that the diagenetic boundary at all sites in the incoming plate occurs at the same thermal maturity of the sediments (TTI=0.025), similar to observations on onshore sequences in Japan (Sasaki, 1986).

  15. Effects of weathering on performance of intumescent coatings for structure fire protection in the wildland-urban interface

    NASA Astrophysics Data System (ADS)

    Bahrani, Babak

    as SDT). For each coating type and weathering period, three different radiative heat flux levels were used in the combustibility tests. Data obtained from the tests, including flammability and thermal properties, were gathered, analyzed, and compared to non-weathered specimens. The results revealed visible effects of weathering on pre (and up to)-ignition flammability and intumescent properties, especially decreases in Time-to-Ignition (TTI), Time-to-Intumescence (tintu.), and (maximum) Intumescence Height (Hintu.) values in weathered specimens. These results showed that the ignition resistance of the coating layers decreased after weathering exposure. On the other hand, the obtained results from weathered specimens for the post-ignition flammability properties, especially Peak Heat Release Rate (PHRR) and Effective Heat of Combustion (EHC) did not show a significant difference in comparison to the non-weathered samples. These results demonstrated that the weathered coating layer would not likely to act as an additional combustible fuel to increase fire spread.

  16. Processes Influencing Ozone Levels in Alaskan Forest Fires Plumes during Long-Range Transport over the North Atlantic

    NASA Technical Reports Server (NTRS)

    Real, E.; Law, K. S.; Wienzierl, B.; Fiebig, M.; Petzold, A.; Wild, O.; Methven, J.; Arnold, S.; Stohl, A.; Huntrieser, H.; Roiger, A.; Schlager, H.; Stewart, D.; Avery, M.; Sachse, G.; Browell, E.; Ferrare, R.; Blake, D.

    2006-01-01

    A case of long-range transport of a biomass burning plume from Alaska to Europe is analyzed using a Lagrangian approach. This plume was sampled several times in the free troposphere over North America, the North Atlantic and Europe by 3 different aircraft during the IGAC Lagrangian 2K4 experiment which was part of the ICARTT/ITOP measurement intensive in summer 2004. Measurements in the plume showed enhanced values of CO, VOCs and NOy, mainly in form of PAN. Observed O3 levels increased by 17 ppbv over 5 days. A photochemical trajectory model, CiTTyCAT, is used to examine processes responsible for the chemical evolution of the plume. The model was initialized with upwind data, and compared with downwind measurements. The influence of high aerosol loading on photolysis rates in the plume is investigated using in-situ aerosol measurements in the plume and lidar retrievals of optical depth as input into a photolysis code (Fast-J), run in the model. Significant impacts on photochemistry are found with a decrease of 18 percent in O3 production and 24 percent in O3 destruction over 5 days when including aerosols. The plume is found to be chemically active with large O3 increases attributed primarily to PAN decomposition during descent of the plume towards Europe. The predicted O3 changes are very dependent on temperature changes during transport, and also, on water vapor levels in the lower troposphere which can lead to O3 destruction. Simulation of mixing/dilution was necessary to reproduce observed pollutants level in the plume. Mixing was simulated using background concentrations from measurements in air masses in close proximity to the plume, and mixing timescales (averaging 6.25 days) were derived from CO changes. Observed and simulated O3/CO correlations in the plume are also compared in order to evaluate the photochemistry in the model. Observed slopes changed from negative to positive over 5 days. This change, which can be attributed largely to photochemistry, is

  17. Astrobiology - The New Synthesis

    NASA Astrophysics Data System (ADS)

    Sik, A.; Simon, T.

    to let acids and alkalis into their cells. - Halophiles: these species are identified from salt lakes, salt mines and salt crystals (some of these are 250 million years old). The salt concentration of their cytoplasm is extreme high so the outer salt can not enter. 2. Extremophiles and evolution Jelentősek az extremofilek evolúciós evolution as- pects vonatkozásai, mivel igen sok ősbaktériumot archaea találunk közöttük. A hagyományos nézet, mely szerint az élővilág a baktériumok bacteria és eukar- ióták eukaryotes birodalmára osztható, a 70-es évek végén (Woese et al), 80-as évek elején (Fox et al) ingott meg, amikor a 16S rRNS (az élővilág egyik legkonz- ervatívabb molekuláris szerkezete molecular structure) összehasonlító szekvenciav- izsgálatai comparative sequence analysis alapján kiderült: az ősbaktériumok különválasztása a legmagasabb rendszertani taxonomy level szinten is indokolt, tehát külön birodalmat separate domain képeznek. Az eddigi genomtérképezések genome sequencing során kiderült, hogy az ősbaktériumok egyes génjei csak eukar- iótákban találhatók meg, nagyobb részük pedig teljesen egyedi [14]. Újabb elméletek szerint az eubaktériumok és ősbaktériumok közös őstől származ- nak, az eukarióták pedig az ősbaktériumokból fejlődhettek ki [15]. Az ősbaktériumok az egyetemes őshöz (LUCA - "last universal common ancestor") legközelebb álló élő kövületek living fossils lehetnek. Luca: az RNS-világ RNS world, a ribo-organizmusok ribo organisms utáni első orga- nizmus, amelyben már kialakult a fehérjék proteins és a DNS DNS mai szerepe. Az ősbaktériumok tanulmányozásával tehát a közel 4 milliárd évvel ezelőtti földi körülményekre következtethetünk. Az utóbbi években a földkéregben felfedezett gazdag extremofil-társulások alapján megdőlni látszik az a hagyományos nézet, mely szerint Luca egy meleg felszíni pocsolyában tenyészett, s divatoss