Science.gov

Sample records for 90-day petition finding

  1. 77 FR 55458 - Endangered and Threatened Species; 90-Day Finding on Petition To Delist the Southern Oregon...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-10

    ... these petitions was published on October 7, 2011 (76 FR 62375) and a second negative 90-day finding for the fourth petition was published on January 11, 2012 (77 FR 1668). The new petition largely..., and drought) rather than man-made factors are responsible for the decline in coho salmon...

  2. 78 FR 46322 - Endangered and Threatened Species; 90-Day Finding on Petition To Delist the Southern Oregon...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-31

    ... artificially produced hatchery stocks (70 FR 37160; June 28, 2005). The SCWUA has previously submitted several... be warranted. Negative 90-day findings were published for these petitions on October 7, 2011 (76 FR 62375), January 11, 2012 (77 FR 1668), and September 10, 2012 (77 FR 55458). SCWUA Petition In this...

  3. 76 FR 9309 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Sand...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-17

    ...We, the U.S. Fish and Wildlife Service, announce a 90-day finding on a petition to list the sand verbena moth, Copablepharon fuscum, as endangered or threatened under the Endangered Species Act of 1973, as amended. Based on our review, we find the petition presents substantial information indicating that listing the sand verbena moth may be warranted. Therefore, with the publication of this......

  4. 76 FR 60431 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the American...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-29

    ..., 2005, the Service issued a 90-day finding (70 FR 38849), which found that the petition presented... threatened or ] endangered was not warranted (72 FR 4967). Species Information This section is a summary of the species information presented in the Service's 2007 12-month finding (72 FR 4967),...

  5. 75 FR 52928 - Endangered and Threatened Wildlife and Plants; Notice of 90-Day Finding for a Petition to List...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-30

    ... rockfish and tiger rockfish) was insubstantial and we therefore did not conduct status reviews (64 FR 33037... segments of Puget Sound/Georgia Basin distinct population segments of rockfish, 75 FR 22276 (April 28, 2010...; Notice of 90-Day Finding for a Petition to List Georgia Basin Populations of China Rockfish and...

  6. 75 FR 42059 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Giant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-20

    ... that listing the GPE may be warranted (72 FR 57273). On January 24, 2008, the petitioners filed a... presented a threat (72 FR 57273). The 2009 petition includes a letter of support from Samuel W. James... educational purposes as a potential threat to the GPE. In our October 9, 2007, 90-day finding (72 FR 57273)...

  7. 77 FR 43799 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Gila...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-26

    ... for feeding, breeding, and sheltering; (b) Genetics and taxonomy; (c) Historical and current range... Regional Office. On December 16, 2009 (74 FR 66866), we published a partial 90-day finding on the petition... from dog and horse waste, manipulation and alteration of streamflow by swimmers, and the trampling...

  8. 77 FR 21920 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Eastern...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-12

    ... a notice of a 90-day finding for the petition in the Federal Register on July 22, 1994 (59 FR 37439... warranted but precluded by other higher priority actions (60 FR 15281). At that time, a listing priority..., 2005 (70 FR 24870). On October 7, 2002, as part of an agreement regarding multiple species, the...

  9. 75 FR 18782 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List Thorne's...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR Fish and Wildlife Service 50 CFR Part 17 Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List Thorne's Hairstreak Butterfly as Endangered Correction In Federal...

  10. 76 FR 23256 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Arapahoe...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-26

    ... assertion in the petition that mountain biking can cause soil erosion and compaction, degraded water quality... the western United States have been well documented, and include increased soil erosion, sedimentation... published two 90-day findings, on January 6, 2009 (74 FR 419), and February 5, 2009 (74 FR 6122)....

  11. 75 FR 1744 - Endangered and Threatened Wildlife and Plants; Partial 90-Day Finding on a Petition to List 475...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-13

    ... endangered under the Act (16 U.S.C. 1531 et seq.) (74 FR 66865). We found that the petition presented... Finding on a Petition to List 475 Species in the Southwestern United States as Threatened or Endangered... petition finding; correction. SUMMARY: On Wednesday, December 16, 2009, we, the U.S. Fish and...

  12. 76 FR 78898 - Endangered and Threatened Wildlife; 90-Day Finding on Petition To List the Barndoor Skate, Winter...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-20

    ... does not present substantial scientific information indicating the petitioned actions may be warranted... skate as a threatened or endangered DPS. The joint USFWS/NMFS petition management handbook ( http://www... finding as to whether a petition to list, delist, or reclassify a species presents substantial...

  13. 76 FR 66255 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to Delist the Coastal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-26

    ... our 12-month finding. Petition History We received a petition, dated April 9, 2010, from the Pacific... Federal Register publications since its inclusion as a category two candidate species in 1982 (47 FR 58454... coastal California gnatcatcher (56 FR 12146), and concluded that substantial information was presented...

  14. 76 FR 36053 - Endangered and Threatened Wildlife and Plants; Revised 90-Day Finding on a Petition To Reclassify...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-21

    ...-day finding published on February 21, 2007 (72 FR 7843), constituted our compliance with the... Columbia vacated and remanded our February 21, 2007, not- substantial 90-day finding (72 FR 7843) back to... endangered species on June 4, 1973 (38 FR 14678), pursuant to the Endangered Species Conservation Act of...

  15. 76 FR 10299 - Endangered and Threatened Wildlife and Plants: 90-Day Finding on a Petition To List the Wild...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-24

    ... completed a 90-day finding on August 15, 2007 (72 FR 45717). Based upon the information available at that... FR 54707), for the Arctic grayling (Thymallus arcticus) and a 12-month finding published on September 22, 2010, for the plant Agave eggersiana (75 FR 57720), we have focused on wild populations in...

  16. 75 FR 23654 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List Hermes Copper...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-04

    ... finding (71 FR 44966, August 8, 2006) is limited to Marschalek and Deutschman's (2008) study of the effect... previous 90-day finding published in the Federal Register on August 8, 2006 (71 FR 44966). Previous Federal... Hermes copper (71 FR 44966) or Thorne's hairstreak butterflies (71 FR 44980) was warranted. (For...

  17. 75 FR 19925 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List a Distinct...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-16

    ... Biodiversity Project, and others requesting that the Pacific fisher (Martes pennanti pacifica) be listed as an... 90-day finding (56 FR 1159) indicating that the fisher in the Pacific States is a distinct population... habitat needs, population size and trends, and demographic parameters (56 FR 1159). On December 29,...

  18. 78 FR 23533 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To Delist the Wood Bison

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-19

    ... February 8, 2011 (76 FR ] 6734). Please refer to that document for the complete listing history. Here we... Wildlife, which was published in the Federal Register on June 2, 1970 (35 FR 8491). In 1974, the first list... of Wild Fauna and Flora (CITES). In a 90-day finding published on November 25, 1998 (63 FR 65164),...

  19. 76 FR 10310 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-24

    ... petition finding (59 FR 28741), we determined that, although the S. adiaste adiaste may be declining... by nonnative plants, livestock grazing, and over- collection (December 5, 1997, 62 FR 64306, pp... butterflies. The primary threat to the Callippe (62 FR 64306), Behren's (62 FR 64306), Myrtle's (June 22,...

  20. 75 FR 50739 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List Brian Head...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-17

    ... be warranted (74 FR 6122). That finding included the Brian Head mountainsnail in a table of species... on a Petition to List Brian Head Mountainsnail as Endangered or Threatened with Critical Habitat... Head mountainsnail (Oreohelix parawanensis) as endangered or threatened under the Endangered...

  1. 77 FR 9618 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-17

    ... Hot Springs) and Drs. Brendan Bohannan and Richard Castenholz (University of Oregon) requesting that... other differences to distinguish the petitioned entity from thermophilic ostracods in other hot springs...) reported finding what they considered to be a new undescribed species of Potamocypris at Hunter's...

  2. 76 FR 25660 - Endangered and Threatened Wildlife; Notice of 90-Day Finding on a Petition to Revise Critical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-05

    ... presents substantial scientific information indicating that the petitioned action may be warranted for... Club, dated February 22, 2010, was found not to present substantial scientific information indicating... substantial scientific information indicating that the revision may be warranted. The finding is to...

  3. 75 FR 51969 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List the Oklahoma...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-24

    ..., deer, or other herbivores, may threaten Calopogon oklahomensis (Petition, p. 10). Evaluation of... indicating whether overgrazing or natural predation by insects, rodents, deer, or other herbivores,...

  4. 77 FR 75091 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To Delist the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-19

    ... on a Petition To Delist the Southern Selkirk Mountains Population of Woodland Caribou AGENCY: Fish... petition to delist the southern Selkirk Mountains population of woodland caribou (Rangifer tarandus caribou... substantial information indicating that delisting this population of the woodland caribou subspecies may...

  5. 77 FR 1668 - Endangered and Threatened Species; 90-Day Finding on Petition To Delist the Southern Oregon...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-11

    ... citations to articles on ocean temperature, heat content and volcanic activity in the Pacific Ocean. However... published in the Federal Register on October 7, 2011 (76 FR 62375). The current petition largely...

  6. 78 FR 66675 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List Multiple Species of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-06

    ... purposes of listing, delisting, and reclassifying a species under the ESA (``DPS Policy''; 61 FR 4722..., whether and the extent to which the petitioned species reproduce through self-fertilization is not...

  7. 78 FR 13614 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List the Humphead Wrasse as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-28

    ..., delisting, and reclassifying a species under the ESA (``DPS Policy''; 61 FR 4722; February 7, 1996). A... publications, copies of reports or letters from authorities, and maps (50 CFR 424.14(b)(2)). At the 90-day..., including parts of Fiji, southwestern Indian Ocean and the South China Sea (Sadovy et al., 2003). Threats...

  8. 75 FR 22063 - Endangered and Threatened Wildlife and Plants; 90-day Finding on a Petition to List the Mohave...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-27

    ... threatened species. At that time, the species was a category 2 candidate (November 15, 1994; 59 FR 58988... petitioned action may be warranted (60 FR 46569). Species Information The Mohave ground squirrel..., cinnamon gray, and pinkish cinnamon without stripes or flecking. The underparts of the body and the...

  9. 76 FR 15947 - Endangered and Threatened Wildlife; Notice of 90-Day Finding on a Petition To List the Caribbean...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-22

    ..., delisting, and reclassifying a species under the ESA (61 FR 4722; February 7, 1996). A species, subspecies... area and concentrating in surf zones adjacent to barrier beaches and on offshore sand bars in warm.... The petition references the Reef Environmental Education Foundation's (REEF) database sightings of...

  10. 78 FR 69376 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List 19 Species and 3...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-19

    ... species under the ESA (61 FR 4722; February 7, 1996). A species, subspecies, or DPS is ``endangered'' if... population growth, loss of coral reef habitat, overutilization by fisheries, disease, lack of adequate... focus on coral reef habitat loss when only one petitioned species was identified as found on coral...

  11. 77 FR 47003 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on Petitions To List the Two Spring...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-07

    ... Spring Mountains Dark Blue Butterflies Petition On November 21, 1991 (56 FR 58804), we added Euphilotes... FR 58982). ] In the February 28, 1996, Candidate Notice of Review (CNOR) (61 FR 7595), we adopted a... list of candidate species as a Category 2 candidate species (54 FR 554-579). Morand's...

  12. 76 FR 61531 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List 10 Subspecies...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-04

    ... candidate species (49 FR 21664). This subspecies is currently known as Euphilotes pallescens mattonii. This subspecies was again included in our Category 2 candidate list for November 21, 1991 (56 FR 58804), at which..., 1994 list (59 FR 58982). Please see Table 1. ] Table 1--Petitioned Great Basin Butterflies, With...

  13. 76 FR 50971 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Leona's...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    ... encroachment, and fire (Xerces Society for Invertebrate Conservation 2010, pp. 10-11). The petition recognizes... the Leona's little blue butterfly habitat (Xerces Society for Invertebrate Conservation 2010, p. 11... equipment operations to the Leona's little blue butterfly habitat (Xerces Society for...

  14. 76 FR 7528 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To Revise Critical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-10

    ..., on September 19, 1994 (59 FR 48136). Critical habitat for 4 vernal pool crustaceans and 11 vernal... August 6, 2003 (68 FR 46684). The 2003 final critical habitat for the 4 vernal pool crustaceans and 11... February 10, 2006 (71 FR 7119- 7120, 7153, 7194). The petition requested that, pursuant to the Act,...

  15. 75 FR 57431 - Listing Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-21

    ... phrase ``distinct population segment of any species of vertebrate fish or wildlife'' (61 FR 4722). The... fishery and increase the Harpoon category daily incidental retention limit (74 FR 57128; November 4, 2009... candidate species (69 FR 19976; April 15, 2004). Within 12 months of the receipt of the petition (May...

  16. 77 FR 54548 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Eagle...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-05

    ... on a Petition To List the Eagle Lake Rainbow Trout as an Endangered or Threatened Species AGENCY... the Eagle Lake rainbow trout (Oncorhynchus mykiss aquilarum) as an endangered or threatened species... rainbow trout may be warranted. Therefore, with the publication of this notice, we are initiating a...

  17. 75 FR 838 - Endangered and Threatened Wildlife; Notice of 90-Day Finding on a Petition to List Atlantic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-06

    ... important factors contributing to the continued decline of this species. The petition also cites global warming as a factor that will become increasingly significant as a stressor on Atlantic sturgeon... Vertebrate Population Segments under the Endangered Species Act (61 FR 4722; February 7, 1996). This...

  18. 76 FR 7820 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition to List the Texas Pipefish as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-11

    ... petition (74 FR 419). (The Texas pipefish is a marine fish that primarily uses seagrass habitat within... threats to the species'' (74 FR 419). With respect to application of the listing factors in ESA section 4... action may be warranted for the Texas pipefish (74 FR 419; January 6, 2009). ESA Statutory and...

  19. 75 FR 1567 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List the Eastern...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-12

    ... on a Petition to List the Eastern Population of the Gopher Tortoise as Threatened AGENCY: Fish and... population of the gopher tortoise (Gopherus polyphemus) as threatened under the Endangered Species Act of... eastern population of the gopher tortoise (Gopherus polyphemus) as threatened in the Federal Register...

  20. 77 FR 59582 - Endangered and Threatened Wildlife; 90-Day Finding on Petitions To List the Northeastern Pacific...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-28

    ... population segment'' for the purposes of listing, delisting, and reclassifying a species under the ESA (61 FR...; Domeier et al., 2012). White sharks commonly inhabit coastal and continental shelf waters, although they... Services' DPS policy (61 FR 4722; February 7, 1996). The WildEarth Guardians petition asserts that all...

  1. 78 FR 24701 - Endangered and Threatened Wildlife; 90-Day Finding on Petitions To List the Great Hammerhead...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-26

    ... indicate that hypoxic occurrences and dead zones, a result of growing human populations, urban pollution... dead zones (Driggers and Hoffmayer, personal communication, 2013). In addition, both petitions assert...'' for the purposes of listing, delisting, and reclassifying a species under the ESA (61 FR...

  2. 78 FR 53391 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To Delist the North Pacific...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-29

    ... the phrase ``Distinct Population Segment,'' or DPS (61 FR 4722; February 7, 1996). The DPS Policy... a determination that a petitioned action may be warranted. As a general matter, these decisions hold... patterning, dark dorsal coloration, a highly varied acoustic call (termed song) and a diverse repertoire...

  3. 75 FR 35746 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List the Honduran...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-23

    ... on a Petition to List the Honduran Emerald Hummingbird as Endangered AGENCY: Fish and Wildlife... endangered under the Endangered Species Act of 1973, as amended (Act), the Honduran emerald hummingbird... indicating that listing the Honduran emerald hummingbird may be warranted. Therefore, with the publication...

  4. 75 FR 21568 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List the Harlequin...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... on a Petition to List the Harlequin Butterfly as Endangered AGENCY: Fish and Wildlife Service... butterfly (Atlantea tulita), a butterfly endemic to Puerto Rico, as endangered under the Endangered Species... butterfly may be warranted. Therefore, with the publication of this notice, we are initiating a review...

  5. 76 FR 20613 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List Spring...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-13

    ... and Threatened Wildlife and Plants (56 FR 58804, November 21, 1991; 59 FR 58982, November 15, 1994... Review (61 FR 7595), we adopted a single category of candidate species defined as follows: ``Those... on a Petition To List Spring Mountains Acastus Checkerspot Butterfly as Endangered AGENCY: Fish...

  6. 76 FR 46238 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List the Straight...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-02

    ... runoff to streams that leads to increased erosion, turbidity, and sedimentation (Petition, p. 12... annual crops within the Potlatch River watershed has left the soil susceptible to wind and water (precipitation runoff) erosion, and resulted in increased overland surface flow and decreased infiltration...

  7. 76 FR 67652 - Listing Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-02

    ... candidate species (69 FR 19976; April 15, 2004). Within 12 months of the receipt of the petition (August 5... warranted, we will determine whether any populations of these species meet the DPS policy criteria (61 FR... regarding listings under the ESA, including a policy for peer review of scientific data (59 FR 34270)....

  8. 77 FR 26478 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List the Dwarf Seahorse as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-04

    ... timeframe, geographic area, and system (i.e., estuary, coastal water, or bay). In Texas, the petition cites a 90 percent decline in ``vascular vegetation'' which occurred within the Galveston Bay system on... population segment'' for the purposes of listing, delisting, and reclassifying a species under the ESA (61...

  9. 75 FR 32728 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List van Rossem's...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-09

    ... in the food chain). Additionally, as cited in the petition, the San Diego National Wildlife Refuge... Regarding the Recognition of Distinct Vertebrate Population Segments under the Endangered Species Act, 61 FR..., 1994, notice of candidate review (59 FR 58982). Category 2 taxa were defined as those taxa for...

  10. 76 FR 30082 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Spot...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-24

    ...-tailed earless lizard (Holbrookia lacerata) as endangered or threatened under the Endangered Species Act... petition presents substantial scientific or commercial information indicating that listing this species may... status of the species to determine if listing the spot-tailed earless lizard is warranted. To ensure...

  11. 75 FR 38776 - Endangered and Threatened Wildlife and Plants; 90-Day Finding for a Petition to List Puget Sound...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-06

    ... also includes smolt (juvenile salmon) production data for Big Beef Creek, describing it as representing..., 1201 NE Lloyd Boulevard, Suite 1100, Portland, OR 97232. The petition and supporting data are available... our Policy on Applying the Definition of Species under the ESA to Pacific Salmon (56 FR...

  12. 78 FR 72622 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List 11 Tarantula...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-03

    ... Finding Species Common name(s) Current range Poecilotheria fasciata banded parachute Sri Lanka. spider, Sri Lankan ornamental tarantula, lemon- legged tiger spider, Thada kaha iri padethi divimakuluwa. Poecilotheria formosa beautiful India. parachute spider, finely formed parachute spider, Salem...

  13. 76 FR 56607 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List 42 Great...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-13

    ... information on: (1) The species' biology, range, and population trends, including: (a) Habitat requirements... States (August 18, 2009; 74 FR 41649); thus, these three species are not included in this finding. In the... identifies invasive, nonnative species (fish, invertebrates, amphibians, and vegetation) as a threat to...

  14. 75 FR 13717 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List the Southern...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-23

    ..., Texas pimpleback, false spike, Mexican fawnsfoot, and Texas fawnsfoot, in a separate finding (74 FR..., and Pascagoula Rivers in Mississippi, the Pearl River in Mississippi and Louisiana, and the Amite River in Mississippi and Louisiana (Hartfield and Ebert 1986, p. 23; Hartfield and Rummel 1985, p....

  15. 76 FR 31903 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to Reclassify the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-02

    ... endangered under the Act (41 FR 24062). All species were found to have declining numbers due to the present.... On September 23, 1999 (64 FR 51499), we published in the Federal Register a finding, in accordance... Under the Endangered Species Act'' (61 FR 4722, February 7, 1996), three elements are considered in...

  16. 77 FR 25687 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition to List Speckled Hind as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-01

    ... number of coral stressors, including coral bleaching, disease, tropical storms, coastal development and... speckled hind. A negative finding for goliath grouper was made on June 1, 2011 (76 FR 31592), while the... FR 4722; February 7, 1996). A species, subspecies, or DPS is ``endangered'' if it is in danger...

  17. 75 FR 17062 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List Thorne's...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-05

    ... listing Thorne's hairstreak (71 FR 44980) or Hermes copper butterflies (71 FR 44966) was warranted. (For a... finding, please see the August 8, 2006 Federal Register Notice (71 FR 44980)). On March 17, 2009, CBD and... the Federal Register on August 8, 2006 (71 FR 44980). ] Evaluation of Information for this...

  18. 78 FR 50032 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List the Whale Shark as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ...)(3)(A) of the ESA of 1973, as amended (U.S.C. 1531 et seq.), requires, to the maximum extent... Federal Register (16 U.S.C. 1533(b)(3)(A)). When we find that substantial scientific or commercial... segment (DPS) that interbreeds when mature (16 U.S.C. 1532(16)). A joint NOAA-U.S. Fish and...

  19. 77 FR 48934 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Bicknell...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-15

    ... projected impacts to the Canadian portion of the species' breeding range; (b) Impacts to forest habitats in... announced that finding in the Animal Candidate Review for Listing as Endangered or Threatened Species (59 FR... thrush from candidate status (61 FR 64481). Although the Bicknell's thrush was removed from the list...

  20. 77 FR 59357 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List Spring...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-27

    ... published a 90-day petition finding (76 FR 20613) in which we concluded that the petition and information in... centimeters (cm)) (Opler 1999, p. 299). The upperside of the wing is a spider-web-like pattern of orange...

  1. 77 FR 19755 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition to List the San...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-02

    ..., we published a 90-day finding (58 FR 36184) in the Federal Register that the petition contained... FR 869) on the petition to list the longfin smelt. We determined that the petitioned action was not... FR 24911) in which we concluded that the petition provided substantial information indicating...

  2. 76 FR 32911 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the Striped...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-07

    ... petition in early 2010. On March 23, 2010, we published a 90-day finding (75 FR 13720) that the petition... information (75 FR 13720, March 23, 2010). Below, we briefly summarize previously presented information, and.... However, in our 90-day finding (75 FR 13720, March 23, 2010), we determined that there was no evidence...

  3. 90-Day Cycle Handbook

    ERIC Educational Resources Information Center

    Park, Sandra; Takahashi, Sola

    2013-01-01

    90-Day Cycles are a disciplined and structured form of inquiry designed to produce and test knowledge syntheses, prototyped processes, or products in support of improvement work. With any type of activity, organizations inevitably encounter roadblocks to improving performance and outcomes. These barriers might include intractable problems at…

  4. 76 FR 63443 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List Northern...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-12

    ... petitions--one for mountain-prairie species, and one for southwest species. On February 5, 2009 (74 FR 6122.... Two additional species were reviewed in a January 6, 2009, 90-day finding (74 FR 419) and, therefore... finding (74 FR 41649) on 38 species from the petition to list 206 species in the mountain-prairie...

  5. 78 FR 68659 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-14

    ... published a 90-day finding in the Federal Register (71 FR 6241) determining that the petition did not..., 2008, we published a 12-month finding on the petition to list the Gunnison's prairie dog (73 FR 6660... notice of review process (73 FR 75175, December 20, 2008; 74 FR 57804, November 9, 2009; 75 FR...

  6. 78 FR 40104 - Endangered and Threatened Wildlife; 12-Month Finding on Petitions To List the Northeastern...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-03

    ... September 28, 2012, we published a positive 90-day finding (77 FR 59582) announcing that both petitions... describing what constitutes a DPS under the ESA (61 FR 4722). The joint DPS policy identifies two criteria... Species' and `Threatened Species' '' (76 FR 76987; December 9, 2011), which is consistent with our...

  7. 76 FR 3069 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To Delist or...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-19

    .... We published a notice May 21, 2010 (75 FR 28636), announcing the review of Acmispon dendroideus... either plant. A notice of review initiation was published for the two Eureka Valley plants in 1983 (48 FR 55100; December 8, 1983), 1991 (56 FR 56882; November 6, 1991), and 2005 (70 FR 39327; July 7,...

  8. 77 FR 71757 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List Phoenix...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-04

    ... research, education, propagation, as well as the economic advantages of the grove's production of high... cultivar is vegetative (asexual; only one plant is involved and the offspring is genetically identical to its parent). Propagation is accomplished by removing offshoots (lateral shoot from the main stem...

  9. 77 FR 45 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List Sierra Nevada...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-03

    ... caused by Neorickettsia helminthoeca, a bacteria that can be carried by trout and salmon. If an infected fish is ingested by a dog or other canid, the bacteria can result in fever, anorexia, vomiting, and... Biological Diversity 2011, p. 33), such as genetic drift, demographic fluctuations related to mating...

  10. 77 FR 47583 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List Desert...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-09

    ...) with presumably similar timeframes of hibernation in other parts of its range. They commonly use rodent burrows for hibernation and as birthing sites (Mackessy 2005, pp. 16-17, 23; Mackessy 2007, p. 8). They... locations used for winter hibernation and those used during active periods (Ernst and Ernst 2003, p....

  11. 76 FR 56381 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Franklin...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-13

    ... bee (54 FR 554). Category 2 candidates were species for which we had information indicating that... in Candidate Review notices published on November 21, 1991 (56 FR 58804) and November 15, 1994 (59 FR... FR 64481; December 5, 1996). Franklin's bumble bee has not held a Federal conservation...

  12. 77 FR 67784 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List the Heller...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-14

    ... planning document as core habitat for eastern small-footed bat (Myotis leibii) winter hibernation (Western... be avoided within this area so as not to damage the cave in use as a hibernation site (WPC 2006, p... provides a ``winter hibernation site for bat colonies, including the state and global- concern...

  13. 76 FR 40868 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Bay...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-12

    ... information on: (1) The species' biology, range, and population trends, including: (a) Habitat requirements... candidate for protection under the Act in the November 21, 1991, Federal Register (56 FR 58804). It was... 1996 (Notice of Candidate Review; February 28, 1996; 61 FR 7596), and only species for which...

  14. 77 FR 32922 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To Delist or...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-04

    ...) The species' biology, range, and population trends, including: (a) Habitat requirements for feeding... designated concurrent with the listing (52 FR 28780, August 3, 1987). At the time of listing, this species... was published for the Inyo California towhee in 2006 (71 FR 14538, March 22, 2006). A 5-year...

  15. 75 FR 46894 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Mexican...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-04

    ... endangered subspecies on April 28, 1976 (41 FR 17742). The gray wolf species (Canis lupus) in North America... threatened (43 FR 9607). This listing of the species as a whole subsumed the previous Mexican wolf subspecies... the purpose of research and conservation (43 FR 9607). We initiated recovery programs for the...

  16. 76 FR 61825 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List 29 Mollusk...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-05

    ... convexus........ Yes Yes. Chelan mountainsnail Oreohelix n. sp. 1......... No Yes. Cinnamon juga Juga n. sp.... We are initiating a status review to determine whether listing under the Act is warranted. Cinnamon Juga (Juga n. sp. 3) The cinnamon juga is an aquatic snail known from four (USDA and USDI 2007, p....

  17. 77 FR 39670 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List a Distinct...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-05

    ... states, as discussed below. On February 15, 1983 (48 FR 6752), the Service included the black bear in... (55 FR 25341) to list the Louisiana black bear (Ursus americanus luteolus) as threatened in Louisiana... similarity of appearance. On January 7, 1992, a final rule was published in the Federal Register (57 FR...

  18. 77 FR 27403 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Eastern...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-10

    ... Canada (ITIS) (retrieved November 9, 2011, from the Integrated Taxonomic Information System on-line... July to early October (Timmerman and Martin 2003, p. 15). Female eastern diamondbacks reach sexual... birth intervals and gestational periods; females reproduce only every 2 to 4 years, depending on...

  19. 75 FR 16713 - Endangered and Threatened Wildlife; Notice of 90-Day Finding on a Petition to List the Bumphead...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-02

    ..., north to Taiwan and the Yaeyama Islands (Japan), south to the Great Barrier Reef and New Caledonia, to... extirpated in Fiji, and is declining in Palau, Indonesia, and the south end of the Great Barrier Reef, citing..., 2004). They occur in barrier and fringing reefs during the day, but rest in caves or shallow...

  20. 76 FR 31920 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Golden...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-02

    ... conduct this review, we request that we receive information on or before August 1, 2011. Please note that... submitting an electronic comment is 11:59 p.m. Eastern Time on this date. After August 1, 2011, you must... scientific community, industry, and any other interested parties. We seek information on: (1) The...

  1. 76 FR 51929 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To Delist the Valley...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-19

    ... August 10, 1978 (43 FR 35636). A rule re-proposing critical habitat was issued on May 2, 1980 (45 FR... designating critical habitat was published in the Federal Register on August 8, 1980 (45 FR 52803). On June 28... the beetle (70 FR 39327). Information from the public was accepted until September 6, 2005....

  2. 76 FR 23265 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Smooth...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-26

    ... for monogamy, polygamy (extra-pair fertilizations), and brood parasitism (egg-laying in the nests of... actual impacts to the species. If there is exposure to a factor, but no response, or only a positive... of how the species is likely impacted could suffice. The mere identification of factors that...

  3. 75 FR 17363 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List a Stonefly...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-06

    ... information that listing of those species may be warranted (74 FR 419). The stonefly and mayfly were included... collected at a third site in 1978 and 1980 from the Rio Grande, upstream from Radium Springs, Dona Ana.... Concerning the population near Radium Springs, New Mexico, Jacobi et al. (2005) note that the site is in...

  4. 78 FR 57611 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List Alabama Shad as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-19

    ...: Kelly Shotts, Ecologist, by any of the following methods: Electronic Submissions: Submit all electronic... business hours at the street address given above. Instructions: Comments sent by any other method, to any... In 1997, we added Alabama shad to our Candidate Species List (62 FR 37562; July 14, 1997). At...

  5. 76 FR 67401 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List All...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-01

    ..., 2011, notice (76 FR 54423) for more details. FOR FURTHER INFORMATION CONTACT: Janine Van Norman, Chief...-8339. SUPPLEMENTARY INFORMATION: On September 1, 2011, we published in the Federal Register (76 FR.... Hannibal Bolton, (Acting) Director, U.S. Fish and Wildlife Service. BILLING CODE 4310-55-P...

  6. 78 FR 29098 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List Iliamna Lake Seals as a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-17

    ..., climate change, ocean acidification, and the Pebble Project. CBD concludes that the combination of being a... Vertebrate Population Segments under the ESA (DPS Policy, 61 FR 4722; February 7, 1996). This policy... species under the ESA (61 FR 4722; February 7, 1996). The policy established two criteria that must be...

  7. 77 FR 43218 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Sonoran...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-24

    ... mechanisms; and small, isolated populations at risk of loss due to chance events and ongoing climate change... composed of volcanic rock and limestone) (Pilsbry 1939, p. 268; Naranjo-Garcia 1988, p. 84; Pearce and... affecting activity of living Sonorella, with talussnails only active above ground during or following...

  8. 75 FR 48914 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to Delist the Tiger...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-12

    ... lines; and receiving or acquiring big cats if the animals are moved from one State to another (72 FR... 1969 (ESCA) (35 FR 6069, April 14, 1970). We finalized this action on June 2, 1970 (35 FR 8491), but... under Appendix A of the ``U.S. List of Endangered Foreign Fish and Wildlife'' (37 FR 6476, March...

  9. 75 FR 6616 - Endangered and Threatened Wildlife; Notice of 90-Day Finding on a Petition to List 83 Species of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-10

    ... early 1980s as primary factors in this ecological shift (73 FR 72210; November 26, 2008). The petitioner... available to indicate a need to list the species under the ESA'' (71 FR 61022; October 17, 2006). We... permit adaptive management (Policy on the Evaluation of Conservation Efforts; 68 FR 15100; March 28,...

  10. 77 FR 61559 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List Nassau Grouper as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-10

    ... speckled hind were made on June 1, 2011 (76 FR 31592), and May 1, 2012 (77 FR 25687), respectively. ESA... species under the ESA (``DPS Policy''; 61 FR 4722; February 7, 1996). A species, subspecies, or DPS is... impacts and threats to the species. We evaluate any information on specific demographic factors...

  11. 76 FR 55638 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Snowy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-08

    ... 6, 2000; 65 FR 41782) and our extension of the comment period for that proposal (65 FR 64414... the final rule for the designation of critical habitat for wintering piping plover (66 FR 36038; July.... 36-38) made a recommendation that small management units based on demographic considerations might...

  12. 76 FR 304 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Red Knot...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-04

    ... our list of candidate species with a listing priority number of 6 (71 FR 53758-53759). ``Warranted but... threats were determined to be imminent (73 FR 75178-75179, December 10, 2008). Because we determined that... number of 3 for this subspecies (74 FR 57825-57826, November 9, 2009). Accordingly, as we addressed...

  13. 76 FR 72891 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List the Scalloped Hammerhead...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ..., delisting, and reclassifying a species under the ESA (61 FR 4722; February 7, 1996). A species, subspecies... overfished stocks within 2 years'' (76 FR 23794; April 28, 2011). This status determination is specific to... in the Atlantic Ocean, including the Caribbean Sea and Gulf of Mexico (76 FR 53652; August 29,...

  14. 76 FR 12308 - Listing Endangered and Threatened Species: 90-Day Finding on a Petition to List Six Species of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-07

    ....S. DPS of smalltooth sawfish as endangered on April 1, 2003 (68 FR 15674). Smalltooth sawfish whose... reclassifying a species under the ESA (61 FR 4722; February 7, 1996). A species, subspecies, or DPS is... elasmobranches, fertilization in sawfishes is internal. Development is believed to be ovoviviparous. The...

  15. 77 FR 51763 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List the Queen Conch as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-27

    ..., delisting, and reclassifying a species under the ESA (``DPS Policy''; 61 FR 4722; February 7, 1996). A... ESA, including a policy for peer review of scientific data (59 FR 34270). The intent of the peer... September). Fertilization is internal and females lay an average of nine egg masses per season; each...

  16. 78 FR 10601 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition to List 44 Species of Corals as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-14

    ... cycle and include the order Anthoathecatae (hydrocorals). To date, 134 unique coral taxa have been found... role in the distribution of Alaska coral species, including nutrient flows and productivity, water... directly and indirectly affect cold water corals, yet no empirical studies to date have...

  17. 76 FR 62259 - Endangered and Threatened Wildlife and Plants; Partial 90-Day Finding on a Petition To List 404...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-06

    ... Listing as burrowing Endangered or crayfish. Threatened Species; Notice of Review. 56 FR 58804 11/21/1991... crayfish. Threatened Species. 54 FR 554 01/06/1989 ETWP; Animal Florida bog Notice of frog; Review. Greensboro burrowing crayfish. 49 FR 21664 05/22/1984 ETWP; Review of Greensboro Invertebrate...

  18. 76 FR 78891 - Listing Endangered and Threatened Wildlife and Plants; 90-Day Finding on Petitions To List the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-20

    ... climate change to specific impacts on thorny skate. One possibility is that global warming could cause a... any species of vertebrate fish and wildlife'' (61 FR 4722). The joint DPS policy describes two... represent the southernmost population of the species in the world. They state that, as global...

  19. 76 FR 18701 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Peary...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-05

    ... change due to global warming presents the largest threat to the Peary caribou's habitat in that... warming due to global climate change presents the largest threat to both subspecies of caribou. The... become navigable to large ships in the near future based on decreased sea ice due to global warming,...

  20. 78 FR 55046 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To Delist or...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-09

    ... The gypsum wild-buckwheat was federally listed as threatened on February 18, 1981 (46 FR 5730, January... habitat on November 5, 1987 (52 FR 37420, October 6, 1987). A recovery plan was issued September 30, 1991... was federally listed as endangered without critical habitat on October 31, 1988 (53 FR...

  1. 76 FR 18138 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Spring...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-01

    ... habitat (42 FR 60765). We withdrew the critical habitat portion of the proposal on March 6, 1979 (44 FR 12382). We then proposed critical habitat again for the species on July 27, 1979 (44 FR 44418). On... proposed critical habitat designation (effective November 29, 1979) (45 FR 5782). The spring pygmy...

  2. 77 FR 37367 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List the Black...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-21

    ..., 1994 (59 FR 58982). Category 2 candidates were taxa for which information was available indicating that... and threats. In the February 28, 1996, Notice of Review (61 FR 7595), we discontinued the use of... due to heavy deforestation on these islands (Lee and Haney 1999, p. 44, WEG 2011, p. 9). Only...

  3. 75 FR 48294 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-10

    ... reproduction, nutrition, and habitat; (b) Genetics and taxonomy; (c) Historical and current range including... as an endangered species under the Act in 1976 (41 FR 24524, June 16, 1976). It was included in the... be extinct in the wild although known to be extant in cultivation (U45 FR 82480, December 15,...

  4. 76 FR 20911 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Prairie...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-14

    ... trends, including: (a) Habitat requirements for feeding, breeding, and sheltering; (b) Genetics and... Lake, Salt Fork of the Red River, Prairie Dog Town Fork of the Red River, Buck Creek, Pease River... Robinson 2004, p. 126). The peppered and prairie chubs are considered sister species with similar...

  5. 78 FR 19176 - Endangered and Threatened Wildlife; 90-day Finding on a Petition to List Sperm Whales in the Gulf...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-29

    ..., destruction of coastal habitats, water pollution including the Gulf's ``dead zone,'' fishery interactions... listed as a single endangered species throughout their global range (35 FR 8495; June 2, 1970). The... Population Segment,'' or DPS (61 FR 4722; February 7, 1996). The DPS Policy requires the consideration of...

  6. 75 FR 55730 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on Petitions To Delist the Gray...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-14

    .... baileyi), was listed as endangered on April 28, 1976, (41 FR 17736) with its known range given as ``Mexico, USA (Arizona, New Mexico, Texas).'' On June 14, 1976, (41 FR 240624) the subspecies C. l. monstrabilis... as ``Texas, New Mexico, Mexico.'' On March 9, 1978, we published a rule (43 FR 9607) relisting...

  7. 77 FR 1900 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Humboldt...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-12

    ... disease (a carnivore parvovirus), and leptospirosis; however, none of these was known to be a significant... parvovirus, and West Nile virus. Of the 15 radio-collared fishers found dead on the Hoopa Valley Indian Reservation during the pathogen study, 2 had been exposed to canine distemper virus and 6 to canine...

  8. 78 FR 58507 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List 10 Sturgeon...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-24

    ... distribution patterns, particularly regarding their seasonal migrations; (d) Historical and current population... sturgeon (Acipenser baerii). Endangered Decreasing China; Kazakhstan; Mongolia; Russia. Yangtze sturgeon (Acipenser Critically Endangered.. Decreasing China. dabryanus). Russian sturgeon (Acipenser...

  9. 75 FR 39656 - Listing Endangered and Threatened Wildlife and Plants; 90-Day Finding on Petitions to List the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-12

    ... animals have a higher capacity for buffering pH changes, and that the tolerance of CO2 by marine fish... describing what constitutes a DPS of a taxonomic species (61 FR 4722; February 7, 1996). The joint DPS policy... mercury or other bioaccumulated contaminants. The National Shark Research Consortium (NSRC)...

  10. 76 FR 12683 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Texas...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-08

    ... species under the Act on December 30, 1982 (47 FR 58454). Category 2 candidates were taxa for which... a category 2 candidate list (61 FR 64481). Species Information The Texas kangaroo rat (Dipodomys... further investigation of the potential for sylvatic plague to affect the Texas kangaroo rat...

  11. 78 FR 29100 - Endangered and Threatened Wildlife; 90-Day Finding on Petitions To List the Dusky Shark as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-17

    ..., delisting, and reclassifying a vertebrate species under the ESA (61 FR 4722; February 7, 1996) (``DPS Policy... the definition of ``significant'' defined in the Services' DPS Policy and used for DPS analysis (76 FR... list in 1997 (62 FR 37560; July 14, 1997), but subsequently transferred the Northwest Atlantic and...

  12. 75 FR 316 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition to List the Insular Population...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-05

    ... Segments under the ESA (DPS Policy, 61 FR 4722; February 7, 1996). This policy clarifies the agencies... section 3(16)) for the purposes of listing, delisting, and reclassifying a species under the ESA (61 FR... organisms (Briggs, 1961, 1966; Carlquist, 1966). They cite Baird et al. (2008) to support the theory...

  13. 77 FR 4973 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List the San...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-01

    ... Wildlife (List), including the San Bernardino flying squirrel (50 FR 37958). Subsequently, three additional Notices of Review dated January 6, 1989 (54 FR 554), November 21, 1991 (56 FR 58804), and November 15, 1994 (59 FR 58982), were issued and presented an updated compilation of vertebrate and...

  14. 75 FR 13720 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List the Striped...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-23

    ... possible listing under the Act as a Category 2 candidate species (59 FR 58982). In the February 28, 1996, notice (61 FR 7596), the Service discontinued the designation of Category 2 species as candidates and... comparing national forest lands with nearby pine plantations on the Woodville Karst plain in the...

  15. 75 FR 59690 - Endangered and Threatened Wildlife; Notice of 90-Day Finding on a Petition To List Warsaw Grouper...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-28

    ... western Caribbean shelf may be due to the dearth of deep-water fishing in this area (Heemstra and Randall... continental shelf break in waters 180 to 1,700 feet (55 to 525 m) deep, while juveniles may occasionally be... specimens are most often caught incidentally in fisheries for snowy grouper and other deep-dwelling...

  16. 77 FR 51767 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List Five Species of Sturgeon...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-27

    ... spawn in freshwater habitats while spending part of their life cycle in marine or estuarine waters (i.e...--Persian sturgeon; A. stellatus--stellate sturgeon/star sturgeon; A. baerii--Siberian sturgeon; A... species under the ESA (``DPS Policy''; 61 FR 4722; February 7, 1996). A species, subspecies, or DPS...

  17. 76 FR 47123 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List Six Sand Dune...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-04

    ... and threats were not available to support proposed rules (59 FR 58982; November 15, 1994). In the February 28, 1996, Candidate Notice of Review (CNOR) (61 FR 7595), we adopted a single category of... proposed to list Giuliani's dune scarab as endangered or threatened in 1978 (43 FR 35636; August 10,...

  18. 76 FR 78601 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Western...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-19

    ... permanent stream dewatering, and changes in the timing and volume of snowmelt (76 FR 18694, April 5, 2011... impact of warming temperatures and altered precipitation patterns on diminishing sea ice (73 FR 28288... and higher emission standards for light-duty vehicles (75 FR 25324, May 7, 2010), but states that...

  19. 76 FR 54423 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List All...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-01

    ... species (Pan troglodytes) as endangered, whether in the wild or in captivity, pursuant to the Act. We... rule listing the chimpanzee and 25 other species of primates under the Act (41 FR 45990); the...; (2) capture and exportation for use in research labs and zoos; (3) diseases, such as...

  20. 77 FR 24908 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List Aliciella...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-26

    ..., through soil compaction, soil erosion, spread of noxious weeds, heavy metals, and dust pollution, which..., increases erosion, and results in soil degradation. Moreover, the petitioner asserts that livestock trample... could outcompete the Aztec gilia and by trampling the soil, leading to compaction and erosion of...

  1. 77 FR 39666 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List Maytenus cymosa

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-05

    ... 30, 1982 (47 FR 58454), September 27, 1985 (50 FR 39526), January 6, 1989 (54 FR 554), November 21, 1991 (56 FR 58804), September 30, 1993 (58 FR 51144) and November 15, 1994 (59 FR 58982). Category 2... 28, 1996, Notice of Review (61 FR 7595), we discontinued the use of multiple candidate categories...

  2. 75 FR 42033 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List Pinus albicaulis

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-20

    ... soil erosion by physically stabilizing soils, initiating succession as a hardy pioneer or as an early... published in the Federal Register on January 27, 1994 (59 FR 3824). Species Information Pinus albicaulis is... listing actions (e.g., 75 FR 13910, March 23, 2010). The petitioner also cites several other models...

  3. 77 FR 52301 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Prince of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-29

    ... forests to be in a late successional stage of forest development with both vertical and horizontal... to provide adequate amounts of forest habitat and connectivity of suitable structure and composition... squirrel requires old-growth forest to survive and reproduce successfully. While several...

  4. 76 FR 62375 - Endangered and Threatened Species; 90-Day Finding on Petitions To Delist Coho Salmon Under the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-07

    ... California Coast (SONCC) coho salmon ESU, which is listed as threatened (70 FR 37160; June 28, 2005), and... June 28, 2005 (70 FR 37160). In that final rule, we concluded that the SONCC coho salmon ESU includes... Endangered Species Act Listing Determinations for Pacific Salmon and Steelhead'' (70 FR 37204; June 28,...

  5. 78 FR 21086 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List Two...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-09

    ... range compared to its historical range, although patterns of genetic structure may suggest some changes... opportunistic in response to changes in forest structure and composition that are created by fire and insect... Policy) (61 FR 4722; February 7, 1996). Under our DPS Policy, we analyze three elements prior to making...

  6. 75 FR 32869 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List a Distinct...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-10

    ... Policy; 61 FR 4722) on February 7, 1996. The DPS Policy requires the consideration of two elements when.... irremotus) and the eastern timber wolf (C. l. lycaon) in the Great Lakes region (39 FR 1158, January 4, 1974..., 1976 (41 FR 17736), in Mexico and the southwestern United States. On June 14, 1976 (41 FR 24062),...

  7. 75 FR 77602 - Endangered and Threatened Species; 90-Day Finding on Petitions To Delist the Eastern Distinct...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-13

    ... exist regarding global climate change and the potential for the southern part of the range (i.e....regulations.gov without change. All Personal Identifying Information (for example, name, address, etc... April 5, 1990 (55 FR 12645). Critical habitat was designated on August 27, 1993 (58 FR 45269), based...

  8. 76 FR 20302 - Listing Endangered and Threatened Species; 90-Day Finding on a Petition To List Chinook Salmon

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-12

    ... FR ] 11482, 11493; March 9, 1998), and we use it exclusively for defining distinct population... coast Chinook salmon populations that defined the Upper Klamath and Trinity Rivers Chinook salmon ESU as... West Ocean Blvd., Suite 4200, Long Beach, CA 90802-4213. Instructions: All comments received are a...

  9. 76 FR 49412 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List the Saltmarsh Topminnow...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-10

    .... In 2004, NMFS created the Species of Concern list (69 FR 19975; April 15, 2004) to encompass species... include NMFS' recent proposed ESA listing of largetooth sawfish (75 FR 25174): ``Wetland losses in the..., subspecies, or DPS is ``endangered'' if it is in danger of extinction throughout all or a significant...

  10. 77 FR 45571 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To Delist the Green Turtle in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-01

    ...,'' or DPS (61 FR 4722; February 7, 1996). The DPS Policy requires the consideration of two elements when... waters surrounding Culebra Island, Puerto Rico (63 FR 46693; September 2, 1998). ESA-implementing... population segment to the species. A species is ``endangered'' if it is in danger of extinction...

  11. 76 FR 31592 - Endangered and Threatened Wildlife; Notice of 90-Day Finding on a Petition To List Goliath...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-01

    ... grouper (previously known as jewfish) as a candidate species under the ESA (56 FR 26797). On April 15... FR 19976). We transferred 25 candidate species, including goliath grouper, to this species of concern... concern list in 2006 (71 FR 61022). ESA Statutory and Regulatory Provisions and Evaluation...

  12. 78 FR 25044 - Listing Endangered or Threatened Species: 90-Day Finding on a Petition To Include the Killer...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-29

    ... phrase ``Distinct Population Segment,'' or DPS (61 FR 4722; February 7, 1996). The DPS Policy requires... a species as defined by the ESA (67 FR 44133; July 1, 2002). Because of the uncertainties regarding... December 22, 2004 (69 FR 76673). After considering public comments on the proposed rule and other...

  13. 78 FR 6299 - Endangered and Threatened Wildlife; 90-Day Finding on Two Petitions To List White Marlin as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-30

    ..., 2002, that white marlin did not warrant ESA listing (67 FR 57204). In 2006, per a settlement agreement... information regarding the status of and threats to the species (71 FR 76639) and convened a new biological.... After considering the AWMSR, we determined the white marlin was neither threatened or endangered (73...

  14. 77 FR 70727 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List the African...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-27

    ... differentiation that may result in traits such as selective growth, sex ratios, increased vulnerability to threats... African lion populations. Lion bones are being exported to Asia for use in traditional Chinese medicine... (Morris, n.d., p. 6). The putative medicinal benefits are the healing of fractured and broken bones,...

  15. 75 FR 16745 - Endangered and Threatened Species; 90-Day Finding on a Petition to Delist Coho Salmon South of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-02

    ... salmon ESU. The CCC coho salmon ESU was listed as a threatened species on October 31, 1996 (61 FR 56138), and subsequently reclassified as an endangered species on June 28, 2005 (70 FR 37160). For more... FR 33102; June 14, 2004) or ``Final Rule Endangered and Threatened Species; Threatened Status...

  16. 77 FR 70733 - Listing Endangered or Threatened Species: 90-Day Finding on a Petition To Delist the Southern...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-27

    ...' interpretation of the phrase ``Distinct Population Segment,'' or DPS (61 FR 4722; February 7, 1996). The DPS... killer whales did not constitute a species as defined by the ESA (67 FR 44133; July 1, 2002). Because of... December 22, 2004 (69 FR 76673). After considering public comments on the proposed rule and other...

  17. 75 FR 41436 - Endangered and Threatened Wildlife; Notice of 90-Day Finding on a Petition to Revise Critical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-16

    ...; 44 FR 17711, March 23, 1979) as rationale for likewise designating the waters off the Northeast... in nesting behavior, or may affect their nests or their nesting habitats, those Federal agencies...

  18. 75 FR 13068 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List the Berry...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-18

    ... would threaten the Berry Cave salamander population by disrupting the food chain upon which the species... amount of organic matter (salamander food source) entering the cave complex. It could also...

  19. 77 FR 33143 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Southern...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-05

    ... Distinct Vertebrate Population Segments Under the Endangered Species Act (61 FR 4722; February 7, 1996... the Endangered Species Act of 1973, as amended (Act), and designate critical habitat. Based on our... SEARCH field, enter Docket No. FWS-R6-ES- 2012-0023, which is the docket number for this action....

  20. 77 FR 52293 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List Mimulus...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-29

    ... Species (50 FR 39526, September 27, 1985). In that document, we included the species as a Category 2..., 1996 (61 FR 64481). This decision resulted in the deletion of Rocky Mountain monkeyflower from the list... to list 206 species, including Rocky Mountain monkeyflower (74 FR 6122, February 5, 2009). We...

  1. 78 FR 63941 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List 23 Species of Corals as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-25

    ... occurs in the Caribbean, Gulf of Mexico and western Atlantic Ocean. Only Porites eridani is noted as... Ocean side, or the alternate possibility that S. glynni evolved from S. siderea 2 to 2.3 million years...)(3)(A) of the ESA of 1973, as amended (U.S.C. 1531 et seq.), requires, to the maximum...

  2. 77 FR 71759 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Prairie...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-04

    ... landscape. The subspecies lives in a wide range of habitats including forests, prairies, brushy areas..., pp. 1517-1518). Nowak (1999, p. 734) notes that spotted skunks avoid dense forests; however, plains spotted skunks are more likely to occur where the landscape is composed of a high proportion of...

  3. 76 FR 59835 - Endangered and Threatened Wildlife and Plants; Partial 90-Day Finding on a Petition To List 404...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-27

    ..., Tennessee Forests Council, West Virginia Highlands Conservancy, Tierra Curry, and Noah Greenwald (referred... 24, 2011; 75 FR 36035)), spectaclecase (Cumberlandia monodonta) ((currently proposed for listing as endangered (January 19, 2011; 76 FR 3392)), narrow pigtoe (Fusconaia escambia), round ebonyshell...

  4. 77 FR 47352 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List Graptopetalum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-08

    ... and Warren 1994, p. 20). While more typically found in tropical deciduous forests and oak woodlands at... Endangered or Threatened Species (45 FR 82480, December 15, 1980). Category 1 candidates were defined as... Plant Taxa for Listing as Endangered or Threatened Species (48 FR 53640, November 28, 1983). Category...

  5. 76 FR 38095 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Eastern...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    ... Federal Actions On September 18, 1985 (50 FR 37958), November 21, 1991 (56 FR 58804), and November 15, 1994 (59 FR 58982), the Service issued Notices of Review identifying the eastern small-footed bat as a ``category-2 candidate'' for listing under the Act. However, on December 5, 1996 (50 FR 64481), the...

  6. 75 FR 34077 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on Five Petitions to List Seven...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-16

    ... anthracinus was historically known from numerous coastal strand and lowland dry forest locations up to 2,000... occurred in montane dry forest (Magnacca 2005a, p. 2). Although it was previously unknown from the island... indicating that in recent collections, H. assimulans seems to be more common in dry forest at...

  7. 75 FR 30313 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List Castanea pumila

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-01

    ... Federal Action On July 1, 1975 (40 FR 27924), Castanea pumila var. ozarkensis was included as one of the... as an endangered species under the Act in 1976 (41 FR 17 24524). We, however, did not finalize that... candidate on December 15, 1980 (45 FR 82480 82569). It was again advertised as a category 2 candidate...

  8. 78 FR 69033 - Endangered and Threatened Wildlife; 90-Day Finding on Petitions To List the Pinto Abalone as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-18

    ... rebuilding strategy implemented in Mexico in 2000 (OECD, 2012), and stricter measures regulating subsistence..., delisting, and reclassifying a species under the ESA (61 FR 4722; February 7, 1996). A species, subspecies... Sitka Island, Alaska to Baja California, Mexico (Campbell, 2000), and it is the predominant...

  9. 76 FR 36049 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Utah...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-21

    ... 30, 1982 (47 FR 58454), September 18, 1985 (50 FR 37958), and November 15, 1994 (59 FR 58982... February 28, 1996, Notice of Review (61 FR 7595), we discontinued the use of multiple candidate categories... al. 2006, p. 1). Although incidental to this evaluation, it is noteworthy that several of the...

  10. 77 FR 58084 - Endangered and Threatened Wildlife and Plants; 90-Day Findings on Petitions To Delist U.S...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-19

    ... added a new regulation (70 FR 52310) at 50 CFR 17.21(h) that excluded the U.S. captive-bred animals of... their entirety, i.e. wherever found, on June 2, 1970 (35 FR 8491). On November 5, 1991, we published in the Federal Register (56 FR 56491) a proposed rule to list the scimitar-horned oryx, addax, and...

  11. 76 FR 9320 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List Alabama Shad as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-17

    ... (41 to 48) on the lower limb of the anterior gill arch. Alabama shad differ from other members of...: Background In 1997, we added Alabama shad to our Candidate Species List (62 FR 37562; July 14, 1997). At that... (49 FR 38900; October 1, 1984). In 2004, we created the Species of Concern list (69 FR 19975; April...

  12. 75 FR 67341 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Bay...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-02

    ... original collection site, numerous surveys using visual searching and coverboard techniques were conducted... researchers beginning in 1991 (Lazell 1998, p. 970; 2005, p. 787; MNHP 1999). These searches revealed several... glimpse of a possible Bay Springs salamander, subsequent searches in 1995 and 1997 produced no...

  13. 76 FR 12667 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the Mt...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-08

    .... On May 30, 2007, we published a 90- day petition finding (72 FR 29933) in which we concluded that the... of status review (72 FR 29933), and additional scientific information from ongoing species surveys as... quino) (62 FR 2313; January 16, 1997) and Fender's blue butterfly (Icaricia icarioides fenderi) (65...

  14. 78 FR 65938 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition and Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ... published a 90-day finding (77 FR 32922) that concluded that the petition presented substantial scientific... than 200 Inyo California towhees at time of listing in 1987 (52 FR 28780 (August 3, 1987)). Substantial..., 1982, Notice of Review of Candidate Species (47 FR 58454) as a result of habitat loss and...

  15. 75 FR 30338 - Endangered and Threatened Wildlife and Plants; 12-month Finding on a Petition to List the White...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-01

    ... organized around family groups or ``clans,'' comprised of several reproductive females, one or two males of... may be warranted. On November 9, 2004, we announced our 90-day finding (69 FR 64889) that the petition... two females (Clark 1977, p. 76; Hoogland 2010, pers. comm.). White-tailed prairie dogs can...

  16. 76 FR 48777 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the Nueces...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-09

    ... 90-day finding for 270 of the 475 petitioned species on January 6, 2009 (74 FR 419), concluding that... 192 southwestern species by December 9, 2009. On December 16, 2009 (74 FR 66866), we published a... (Richardson and Gold 1995, pp. 31-33). Specimens collected in the Frio River were very similar genetically...

  17. 76 FR 62899 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-11

    ... April 22, 2009, the Service issued its 90-day finding (74 FR 18336), concluding that the petition... with the black-bellied ] slender salamander (B. nigriventris), gregarious slender salamander (B... oviposition occurring in November in the related black-bellied slender salamander. Little is known about...

  18. 76 FR 45129 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the Gopher...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-27

    ... Tombigbee Rivers in Alabama, Louisiana, and Mississippi) (52 FR 25376). On January 18, 2006, we received a... processing the petition in early February, 2007. On September 9, 2009, we published a 90-day finding (74 FR... information through http://www.regulations.gov until March 15, 2010 (75 FR 1567). Thereafter, we...

  19. 76 FR 61298 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the Lake...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-04

    .... We published a notice of 90-day finding in the Federal Register on May 6, 2008 (73 FR 24915... (61 FR 4722), we are required to evaluate the discreteness and significance of the petitioned entity... considered extinct by biologists from Washington Department of Game (now part of Washington Department...

  20. 76 FR 31282 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List Puerto...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-31

    ... published a 90-day finding (75 FR 21568) in which we concluded that the petition provided substantial... Number The Service adopted guidelines on September 21, 1983 (48 FR 43098), to establish a rational system... zone on limestone-derived soil in the Northern karst Region (Ewel and Whitmore 1973, p. 25) and in...

  1. 76 FR 62213 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the Mohave...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-06

    ... that time, the species was a category 2 candidate (November 15, 1994; 59 FR 58982), and was first... action may be warranted (60 FR 46569). On September 5, 2005, we received a petition, dated August 30... CFR 424.14(a). On April 27, 2010, the Service made its 90-day finding (75 FR 22063), concluding...

  2. 77 FR 42238 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List Six Sand...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-18

    ... 1973, as amended (Act). In our 90- day finding on this petition (76 FR 47123, August 4, 2011), we... Mountain serican scarab, may be warranted (76 FR 47123, August 4, 2011). Therefore, no further action is... off-road vehicle (ORV) use (43 FR 35636). The Service stated that ORV activity compacts dead...

  3. 76 FR 61321 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition to List the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-04

    ... January 10, 2008, the Service made its 90-day finding (73 FR 1855), concluding that the petition did... discreteness and significance criteria of the DPS policy (61 FR 4722; February 7, 1996), and, thus, may be a... lizard's nasal passages. The nasal passages are also specialized for desert living; they are...

  4. 77 FR 57921 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List 14 Aquatic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-18

    ... to in the petition and in our 90-day finding (76 FR 61826) as the nerite pebblesnail and the... DPS = distinct population segment FERC = Federal Energy Regulatory Commission FPA = Forest Practice... NBII = National Biological Information Infrastructure NWP = Northwest Forest Plan OHV =...

  5. Findings of graft biopsy specimens within 90 days after ABO blood group incompatible living donor kidney transplantation compared with ABO-identical and non-identical transplantation.

    PubMed

    Ushigome, Hidetaka; Okamoto, Masahiko; Koshino, Katsuhiro; Nobori, Syuji; Okajima, Hideaki; Masuzawa, Naoko; Urasaki, Koji; Yoshimura, Norio

    2010-07-01

    As immunosuppressive therapy has advanced, we have markedly improved the outcome of ABO blood group incompatible living donor kidney transplantation. Consequently, graft survival at early phase after ABO-incompatible transplantation has been favorable than ABO-compatible transplantation in Japan. But in these days, it has been assumed that transplant glomerulopathy within one yr after ABO-incompatible kidney transplantation might be significantly precipitated. That may be because of chronic, active antibody-mediated rejection (AMR). We performed kidney graft biopsies at the early phase within 90 d after living donor kidney transplantation that involved the episode and protocol biopsies and studied findings of graft biopsy specimens when compared with ABO incompatible and compatible involving non-identical and identical transplantations. In ABO-incompatible transplant cases, the ratio occurring glomerulitis, especially severe injury of g 2-3, was significantly higher than that of identical and non-identical transplant cases (p < 0.01). There was no significant difference in t score, i score, ptc score and v score between three transplant groups. The cases occurring AMR were concordant with the cases recognized with severe glomerulitis. AMR was difficult to be diagnosed by C4d analysis in ABO-incompatible transplant cases. Glomerular injury score, g score, may be considered as more significant and the injury should be cured thoroughly.

  6. 29 CFR 551.3 - Petition for a finding.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Petition for a finding. 551.3 Section 551.3 Labor... DELIVERY DRIVERS AND HELPERS; WAGE PAYMENT PLANS § 551.3 Petition for a finding. Any employer desiring to... Administrator, in writing, for a finding under such section and this part. If the wage payment plan with...

  7. 29 CFR 551.3 - Petition for a finding.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false Petition for a finding. 551.3 Section 551.3 Labor... DELIVERY DRIVERS AND HELPERS; WAGE PAYMENT PLANS § 551.3 Petition for a finding. Any employer desiring to... Administrator, in writing, for a finding under such section and this part. If the wage payment plan with...

  8. 29 CFR 551.3 - Petition for a finding.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false Petition for a finding. 551.3 Section 551.3 Labor... DELIVERY DRIVERS AND HELPERS; WAGE PAYMENT PLANS § 551.3 Petition for a finding. Any employer desiring to... Administrator, in writing, for a finding under such section and this part. If the wage payment plan with...

  9. 29 CFR 551.3 - Petition for a finding.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Petition for a finding. 551.3 Section 551.3 Labor... DELIVERY DRIVERS AND HELPERS; WAGE PAYMENT PLANS § 551.3 Petition for a finding. Any employer desiring to... Administrator, in writing, for a finding under such section and this part. If the wage payment plan with...

  10. 29 CFR 551.3 - Petition for a finding.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Petition for a finding. 551.3 Section 551.3 Labor... DELIVERY DRIVERS AND HELPERS; WAGE PAYMENT PLANS § 551.3 Petition for a finding. Any employer desiring to... Administrator, in writing, for a finding under such section and this part. If the wage payment plan with...

  11. 77 FR 3423 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the `I'iwi as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-24

    ...) and nonnative plants (Pratt et al. 2009, p. 152; 75 FR 18959, April 13, 2010). During dry periods... invertebrates and plant material, pigs disturb and destroy native vegetation, and trample plants and...

  12. 75 FR 57426 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To Reclassify the U.S...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-21

    ... population segment (DPS) policy (61 FR 4722; February 7, 1996). (5) Discreteness, significance, and status of... habitat, particularly in south Florida (49 FR 7332). The endangered status covered wood storks in the.... At the time of listing, critical habitat was considered but not designated for this species (49...

  13. Leadership Transitions and the First 90 Days.

    PubMed

    Shirey, Maria R

    2016-04-01

    This department highlights change management strategies that may be successful in strategically planning and executing organizational change initiatives. In this article, the author discusses leadership role transitions and provides a framework for successfully navigating the crucial 1st 90 days in an executive leadership role. PMID:27011151

  14. 77 FR 22749 - Petition To List 83 Species of Coral as Threatened or Endangered Under the Endangered Species Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-17

    ... petitioned species (75 FR 6616). The 90-day finding was followed by a public comment period, during which we..., along with the information received on the 90-day finding (75 FR 6616; February 10, 2010), when we make... workshops on this topic. The Status Review Report examines the biology of, threats to, and extinction...

  15. 77 FR 70987 - Endangered and Threatened Wildlife and Plants; Status Review for a Petition To List the Ashy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-28

    ... a 90-day petition finding (73 FR 28080) in which we concluded that the petition provided substantial... review. On August 19, 2009, we announced our 12-month finding (74 FR 41832) in which we found that, after... refer to our previous 12-month finding published in the Federal Register on August 19, 2009 (74 FR...

  16. 75 FR 22012 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition to List Susan's...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-27

    ... on the food chain), and pollution tolerance were negatively impacted by moderate or heavy grazing in... in November 2008. The 90-day finding was published in the Federal Register on July 8, 2009 (74...

  17. 77 FR 27386 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-10

    ... findings, including one on February 5, 2009 (74 FR 6122) for the mountain-prairie species. That finding... snowfly (76 FR 23256). In that finding, we found that the petition presented substantial information to... received a petition, of the same date, from The Xerces Society for Invertebrate Conservation, Dr....

  18. Towards a 90-Day Monthly Storm Outlook for Alaska

    NASA Astrophysics Data System (ADS)

    Partain, J. L.

    2011-12-01

    In all seasons, storms represent high-impact weather events in Alaska. Alaska's extensive coastline makes the region especially vulnerable to coastal flooding and erosion, particularly where a protective sea ice buffer is absent. There exists a major need for an expanded temporal range of storm outlooks to enable proactive responses by coastal communities and the various industries noted above. The expansion envisioned here is to the 90-day range. The NOAA Climate Prediction Center's (CPC) Storm Tracks website presently includes summaries of storm tracks and accumulated precipitation for the past 10-, 30- and 90-day periods, together with Week-1 and Week-2 forecast storm tracks from the Global Forecast System's (GFS) operational run and the GFS ensemble. Given the limits of deterministic predictability, we will extend the window of the storm outlook to 90 days by drawing upon the present and CPC-predicted states of ENSO, the Pacific Decadal Oscillation, and the Arctic Oscillation -- three large-scale modes of variability known to affect Alaska. In order to link the large-scale modes of variability to storm probabilities in various Alaskan sub-regions, we will explore the use of composites and analog years based on the states of the major teleconnection modes. This presentation will include an end-to-end plan for the development and testing of this product.

  19. 76 FR 61895 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-05

    .... ACTION: Notice of 12-month petition finding. SUMMARY: We, the U.S. Fish and Wildlife Service, announce a... finding is available for public inspection, by appointment, during normal business hours at the U.S. Fish... the Act (16 U.S.C. 1531 et seq.), requires that, for any petition to revise the Federal Lists...

  20. 29 CFR 1987.111 - Withdrawal of complaints, findings, objections, and petitions for review; settlement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 9 2014-07-01 2014-07-01 false Withdrawal of complaints, findings, objections, and petitions for review; settlement. 1987.111 Section 1987.111 Labor Regulations Relating to Labor (Continued... RETALIATION COMPLAINTS UNDER SECTION 402 OF THE FDA FOOD SAFETY MODERNIZATION ACT Miscellaneous...

  1. 76 FR 62165 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List Texas...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-06

    ... this 2008 petition, and on March 23, 2010 (75 FR 13717), we found that the petition did not present... indicating that listing nine Texas mussels may be warranted (74 FR 66260). As a result of the finding, we... release clouds of sperm into the water column, which females draw in through their siphons....

  2. A 90-Day Tenofovir Reservoir Intravaginal Ring for Mucosal HIV Prophylaxis

    PubMed Central

    Johnson, Todd J.; Clark, Meredith R.; Albright, Theodore H.; Nebeker, Joel S.; Tuitupou, Anthony L.; Clark, Justin T.; Fabian, Judit; McCabe, R. Tyler; Chandra, Neelima; Doncel, Gustavo F.; Friend, David R.

    2012-01-01

    A vaginal gel containing the antiretroviral tenofovir (TFV) recently demonstrated 39% protection against HIV infection in women. We designed and evaluated a novel reservoir TFV intravaginal ring (IVR) to potentially improve product effectiveness by providing a more controlled and sustained vaginal dose to maintain cervicovaginal concentrations. Polyurethane tubing of various hydrophilicities was filled with a high-density TFV/glycerol/water semisolid paste and then end-sealed to create IVRs. In vitro, TFV release increased with polyurethane hydrophilicity, with 35 weight percent water-swelling polyurethane IVRs achieving an approximately 10-mg/day release for 90 days with mechanical stiffness similar to that of the commercially available NuvaRing. This design was evaluated in two 90-day in vivo sheep studies for TFV pharmacokinetics and safety. Overall, TFV vaginal tissue, vaginal fluid, and plasma levels were relatively time independent over the 90-day duration at approximately 104 ng/g, 106 ng/g, and 101 ng/ml, respectively, near or exceeding the highest observed concentrations in a TFV 1% gel control group. TFV vaginal fluid concentrations were approximately 1,000-fold greater than levels shown to provide significant protection in women using the TFV 1% gel. There were no toxicological findings following placebo and TFV IVR treatment for 28 or 90 days, although slight to moderate increases in inflammatory infiltrates in the vaginal epithelia were observed in these animals compared to naïve animals. In summary, the controlled release of TFV from this reservoir IVR provided elevated sheep vaginal concentrations for 90 days to merit its further evaluation as an HIV prophylactic. PMID:23006751

  3. 76 FR 20918 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List Hermes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-14

    ... published a 90-day finding for Hermes copper butterfly in the Federal Register (71 FR 44966). The finding... published in 2010 (75 FR 23658, May 4, 2010) Hermes copper butterfly habitat has become fragmented by both... the August 8, 2006, Federal Register finding (71 FR 44966). On March 17, 2009, CBD and David...

  4. Baroreflex Sensitivity Decreases During 90-Day Bed Rest

    NASA Technical Reports Server (NTRS)

    Stenger, M. B.; Arzeno, N. M.; Platts, S. H.

    2008-01-01

    Baroreflex sensitivity (BRS) decreases during spaceflight and simulated spaceflight (head down bed rest [BR]). However, previous studies have only examined BRS in response to a limited blood pressure (BP) range or to a single sudden change in BP. PURPOSE: The purpose of this study was to examine BRS during 90 days of 6deg head-down tilt BR over a broad range of BP perturbations. METHODS: Nineteen normal volunteers (12M, 7F) were tested one day before BR, and then near BR days 30, 60 and 90. BP was pharmacologically altered by continuous infusions of phenylephrine (PE) and sodium nitroprusside (SNP). Electrocardiogram and continuous BP were collected during 10 min of normal saline (NS), followed by increasing concentrations of PE (10 min each of 0.4, 0.8 and 1.6 micro-g/kg/min). After a 20 min break, NS was infused again for 10 min, followed by increasing concentrations of SNP (10 min each of 0.4, 0.8, 1.2 micro-g/kg/min). Baroreceptor sensitivity was measured as the slope of a sequence of 3 or more beats in which the systolic BP and following R-R interval (RR) both increased or decreased. Spectral heart rate variability (HRV) and mean RR were analyzed using data from only the NS infusions. Two-way repeated-measures analysis of variance was performed to examine the effects of BR and gender. RESULTS: RR decreased (p<0.001) from pre- BR across BR days. High frequency in normalized units, a measure of parasympathetic activity, decreased with BR (p=0.027) and was lower (p=0.046) in men (0.39+/-0.02, mean+/-SEM) than women (0.48+/-0.02). The spontaneous baroreflex slope, our measure of BRS, increased with PE and decreased with SNP across BR (p<0.001). The percentage decrease in BRS from pre- to post-BR appeared to be larger in women (43.6+/-7.0%) than in men (31.3+/-3.9%, p=0.06). CONCLUSION: Parasympathetic activity and baroreflex sensitivity decrease during 90 days of BR, and BRS tends to diminish more in women than in men.

  5. 76 FR 44566 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the Frigid...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-26

    ... unreliable aid in systematic analyses. Currently, features of the male and female reproductive tract, the... published a 90-day finding (74 FR 6122) for 165 of the 206 mountain- prairie species, which did not include... finding (74 FR 41649) for 38 mountain-prairie region species, and initiated status reviews on 29 of...

  6. 76 FR 18684 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-05

    ... on January 6, 2009 (74 FR 419), and February 5, 2009 (74 FR 6122), identifying species for which we...-day finding for 38 mountain- prairie region species (74 FR 41649). In that finding, we found that the... requested further information pertaining to all three ``species'' (74 FR 41649). However, the 90-day...

  7. 76 FR 63093 - Endangered and Threatened Wildlife and Plants; 12-Month Finding for a Petition To List the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-11

    ..., and published it in the Federal Register on September 20, 2002 (67 FR 59241). In the finding we... Inyo and Sequoia National Forests, which are administered by the U.S. Forest Service. Range Expansion... publication of the 90-day finding in 2002 (67 FR 59241; September 20, 2002), the California Department of...

  8. 75 FR 19592 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition to List the Wyoming...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-15

    ... indicating that listing the species may be warranted (74 FR 6558). On March 20, 2009, the petitioners... effects to the species from energy development activities. Our February 10, 2009, 90-day finding (74 FR..., and thought to be an adaptive response to predation (Ingles 1950, p. 357; Wlasiuk and Nachman 2007,...

  9. 76 FR 38503 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List a Distinct...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-30

    ... FR 19925). The notice of a 90-day finding and commencement of a 12- month status review for the USNRMs DPS was published in the annual Candidate Notice of Review on November 10, 2010 (75 FR 69222... initiated a 12-month status review (68 FR 41169). On April 8, 2004, we published a warranted...

  10. 75 FR 60515 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition to List the Pygmy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-30

    ... species as a category 2 candidate species (56 FR 58804). A category 2 candidate species was a species for... Review (CNOR) (61 FR 7595), we adopted a single category of candidate species defined as follows: ``Those...). On May 20, 2005, we published a 90-day finding in the Federal Register (70 FR 29253) stating that...

  11. 76 FR 55623 - Endangered and Threatened Wildlife and Plants; 12-Month Petition Finding and Proposed Listing of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-08

    ... participated (71 FR 10608; March 2, 2006; NPS 2006). The original habitat of the plant was threatened by the... new location. Potential immediate threats applicable to the new location, including the danger that... listing may be warranted. The 90-day finding was published on August 10, 2010 (75 FR 48294). This...

  12. 75 FR 67925 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition to List Cirsium...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-04

    ... subspecies (74 FR 46542). On February 11, 2010, WildEarth Guardians filed suit against the Service for... presumed location from Presidio, Texas, that we identified in the 90- day finding (74 FR 46544), is not C... also evidence that discharge from Bitter Creek was once greater (Service 2005a; 70 FR 46312, August...

  13. 77 FR 51958 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the Bay...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-28

    ... under the Act in the November 21, 1991, Federal Register (56 FR 58804). It was assigned a Category 2... of Candidate Review; February 28, 1996; 61 FR 7596), and only species for which the Service has... available during fiscal year 2011, and on July 12, 2011, we published a 90-day finding (76 FR 40868)...

  14. 76 FR 62740 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition and Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-11

    ... CFR 424.14(a)). On July 14, 2009 (74 FR 33957), we published a 90-day finding in which we determined... cockatoo, and yellow-crested cockatoo (76 FR 49202). In this status review we make a determination whether... other accessible areas to plant yams, corn, dasheen, banana, plantain, and sugar cane, and graze...

  15. 76 FR 63479 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List Two South...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-12

    ...(a)). On July 14, 2009 (74 FR 33957), we published a 90-day finding in which we determined that the..., white cockatoo, and yellow-crested cockatoo (76 FR 49202). Current Action In this status review, we make... forests into 6 categories, including permanent production forests. This category includes those forests...

  16. 76 FR 55169 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on Five Petitions To List Seven...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-06

    ... warranted at that time. We published the 90-day finding in the Federal Register on June 16, 2010 (75 FR... Ecosystem The lowland dry ecosystem includes shrublands and forests below approximately 3,300 ft (1,000 m.... longiceps are known from lowland dry forests. These forests are typically dominated by...

  17. 50 CFR 424.14 - Petitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... a petition within 30 days. (b) Petitions to list, delist, or reclassify species. (1) To the maximum extent practicable, within 90 days of receiving a petition to list, delist, or reclassify a species, the... to list, delist, or reclassify species, and (B) Expeditious progress is being made to list,...

  18. 50 CFR 424.14 - Petitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... COMMERCE); ENDANGERED SPECIES COMMITTEE REGULATIONS SUBCHAPTER A LISTING ENDANGERED AND THREATENED SPECIES... a petition within 30 days. (b) Petitions to list, delist, or reclassify species. (1) To the maximum extent practicable, within 90 days of receiving a petition to list, delist, or reclassify a species,...

  19. 50 CFR 424.14 - Petitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... COMMERCE); ENDANGERED SPECIES COMMITTEE REGULATIONS SUBCHAPTER A LISTING ENDANGERED AND THREATENED SPECIES... a petition within 30 days. (b) Petitions to list, delist, or reclassify species. (1) To the maximum extent practicable, within 90 days of receiving a petition to list, delist, or reclassify a species,...

  20. 75 FR 13909 - Endangered and Threatened Wildlife and Plants; 12-Month Findings for Petitions to List the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-23

    ... finding in the Federal Register (69 FR 21484) that these petitions taken collectively, as well as... finding, until July 30, 2004 (69 FR 41445). In accordance with section 4(b)(3)(A) of the Act, we completed... January 12, 2005, we announced our not-warranted 12-month finding in the Federal Register (70 FR 2243)....

  1. 75 FR 78029 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the North...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-14

    ..., 1995, we published a finding (60 FR 19567) that a previous petition, submitted by the Predator Project... scientific and commercial information indicating that listing may be warranted (68 FR 60112). On September 29... published a 12-month finding of ``not warranted'' for the wolverine in the contiguous United States (73...

  2. 76 FR 42631 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List Pinus...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-19

    ... January 27, 1994 (59 FR 3824). On December 9, 2008, we received a petition dated December 8, 2008, from... published in the Federal Register on July 20, 2010 (75 FR 42033). In that finding we determined that the... Pinus albicaulis (75 FR 42033), and received 20 letters from the public. This 12-month finding is...

  3. 76 FR 9722 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List Solanum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-22

    ...), who described the habitat as a dry, deciduous forest. After 1992, six additional populations of... FR 63659) our finding that the petition to list A. eggersiana and S. conocarpum presented substantial... February 28, 2006. On March 7, 2006, we published our 12-month finding (71 FR 11367) that listing of...

  4. The 90-day oral toxicity of d-psicose in male Wistar rats

    PubMed Central

    Matsuo, Tatsuhiro; Ishii, Reika; Shirai, Yoko

    2012-01-01

    d-Psicose is a rare sugar present in small quantities in natural products. In a previous study, we showed that d-psicose suppresses increase in plasma glucose and reduces body fat accumulation in rats. Based on acute toxicity testing in rats, d-psicose is classified as an ordinary substance (LD50 = 16 g/kg). Elucidating the effects of sub-chronic feeding of d-psicose in rats is essential before it can be utilized as a physiologically functional food. In this study, male Wistar rats (3 weeks old) were fed diets containing 3% d-psicose or sucrose for 90 days. The body weight gain and intra-abdominal adipose tissue weight did not differ between the sucrose and the d-psicose groups. The weights of the liver and kidneys were significantly higher in the d-psicose group than in the sucrose group. However, no gross pathological findings were evident at dietary doses of 3% d-psicose or were correlated with hypertrophy of the liver and kidney. In a clinical chemistry analysis, the erythrocyte and leukocyte courts were significantly higher in the d-psicose group, but that was not considered to be toxicologically significant. Therefore, the present study found no adverse effects of d-psicose in rats fed a diet containing 3% d-psicosefor 90 days. PMID:22448098

  5. The 90-day oral toxicity of d-psicose in male Wistar rats.

    PubMed

    Matsuo, Tatsuhiro; Ishii, Reika; Shirai, Yoko

    2012-03-01

    d-Psicose is a rare sugar present in small quantities in natural products. In a previous study, we showed that d-psicose suppresses increase in plasma glucose and reduces body fat accumulation in rats. Based on acute toxicity testing in rats, d-psicose is classified as an ordinary substance (LD(50) = 16 g/kg). Elucidating the effects of sub-chronic feeding of d-psicose in rats is essential before it can be utilized as a physiologically functional food. In this study, male Wistar rats (3 weeks old) were fed diets containing 3% d-psicose or sucrose for 90 days. The body weight gain and intra-abdominal adipose tissue weight did not differ between the sucrose and the d-psicose groups. The weights of the liver and kidneys were significantly higher in the d-psicose group than in the sucrose group. However, no gross pathological findings were evident at dietary doses of 3% d-psicose or were correlated with hypertrophy of the liver and kidney. In a clinical chemistry analysis, the erythrocyte and leukocyte courts were significantly higher in the d-psicose group, but that was not considered to be toxicologically significant. Therefore, the present study found no adverse effects of d-psicose in rats fed a diet containing 3% d-psicosefor 90 days.

  6. 76 FR 10165 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List Astragalus...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-23

    ... indicate that an emergency situation existed for any of the 11 species. On February 5, 2009 (74 FR 6122...-day finding (74 FR 41649) on 38 species from the petition to list 206 species in the mountain-prairie... reproduce mainly by outcrossing (cross-fertilization) (Heil and Melton 1995a, p. 14). Plants that...

  7. 76 FR 59623 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-27

    ... January 6, 2009 (74 FR 419), concluding that the petition did not present substantial information that... status review, which was published in the Federal Register on December 16, 2009 (74 FR 66866). This... commercial information, we find that ] listing any of these three southwestern moth species is not...

  8. 75 FR 3424 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To Remove the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-21

    ... listed as a threatened species on October 1, 1992 (57 FR 45328). On September 1, 2004, we issued a 5-year... finding (73 FR 57314) on the May 28, 2008, petition and found that, although the petitioners based their... Segments (DPS Policy) (February 7, 1996; 61 FR 4722) to help us in determining what constitutes a DPS,...

  9. 78 FR 62523 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List Ashy Storm...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-22

    ... Distinct Vertebrate Population Segments Under the Endangered Species Act (61 FR 4722, February 7, 1996... Finding on a Petition To List Ashy Storm-Petrel as an Endangered or Threatened Species AGENCY: Fish and... homochroa) as an endangered or threatened species and to designate critical habitat under the...

  10. 76 FR 61855 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the Cactus...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-05

    ...), pygmy-owls still occupy suitable habitat in northeastern Mexico and the pygmy-owl's distribution remains... Service, Interior. ACTION: Notice of 12-month petition finding. SUMMARY: We, the U.S. Fish and Wildlife... public inspection, by appointment, during normal business hours at the U.S. Fish and Wildlife...

  11. 12 CFR 220.117 - Exception to 90-day rule in special cash account.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Exception to 90-day rule in special cash... Exception to 90-day rule in special cash account. (a) The Board of Governors has recently interpreted... stock in a special cash account with a member firm on Day 1. On Day 3 customer sold the same stock at...

  12. 19 CFR Annex Viii-A to Part 351 - Schedule for 90-Day Sunset Reviews

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Schedule for 90-Day Sunset Reviews VIII Annex VIII-A to Part 351 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Pt. 351, Annex VIII-A Annex VIII-A to Part 351—Schedule for 90-Day...

  13. 19 CFR Annex Viii-A to Part 351 - Schedule for 90-Day Sunset Reviews

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 3 2011-04-01 2011-04-01 false Schedule for 90-Day Sunset Reviews VIII Annex VIII-A to Part 351 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Pt. 351, Annex VIII-A Annex VIII-A to Part 351—Schedule for 90-Day...

  14. 19 CFR Annex Viii-A to Part 351 - Schedule for 90-Day Sunset Reviews

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 3 2013-04-01 2013-04-01 false Schedule for 90-Day Sunset Reviews VIII Annex VIII-A to Part 351 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Pt. 351, Annex VIII-A Annex VIII-A to Part 351—Schedule for 90-Day...

  15. 19 CFR Annex Viii-A to Part 351 - Schedule for 90-Day Sunset Reviews

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 3 2012-04-01 2012-04-01 false Schedule for 90-Day Sunset Reviews VIII Annex VIII-A to Part 351 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Pt. 351, Annex VIII-A Annex VIII-A to Part 351—Schedule for 90-Day...

  16. 19 CFR Annex Viii-A to Part 351 - Schedule for 90-Day Sunset Reviews

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 3 2014-04-01 2014-04-01 false Schedule for 90-Day Sunset Reviews VIII Annex VIII-A to Part 351 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Pt. 351, Annex VIII-A Annex VIII-A to Part 351—Schedule for 90-Day...

  17. A 90-Day Subchronic Toxicity Study of Submerged Mycelial Culture of Cordyceps cicadae (Ascomycetes) in Rats.

    PubMed

    Chen, Yen-Lien; Yeh, Shu-Hsing; Lin, Ting-Wei; Chen, Chin-Chu; Chen, Chin-Shuh; Kuo, Chia-Feng

    2015-01-01

    Cordyceps cicadae is a parasitic fungus that hibernates inside a host (Cicada flammata Dist.) and then grows its fruiting body on the surface of the insect. The complete insect/fungus combination of C. cicadae has been widely applied in Chinese traditional medicine. Recent studies have demonstrated that the medicinal benefits of cultured mycelia are as effective as those found in the wild. However, toxicological information regarding the chronic consumption of C. cicadae mycelia culture is not available. This study was conducted to evaluate the possible toxicity arising from repeated exposure to freeze-dried submerged mycelial culture of C. cicadae for 90 days. A total of eighty 8-week-old Sprague-Dawley rats were divided into 4 groups (10 males and 10 females in each group). C. cicadae was administered daily to animals by gavage at doses of 0, 500, 1000, and 2000 mg/kg body weight for 90 days. No animal deaths occurred and no treatment-related clinical signs were observed during the study period. No statistical differences in body weight gain, relative organ weight, hematology, serum chemistry, and urinalysis were observed. Gross necropsy and histopathological findings indicated that there was no treatment-related abnormality. Based on the results, the no observed adverse effect level of C. cicadae whole broth is determined to be > 2000 mg/kg for male and female Sprague-Dawley rats. The results of this study provides support for the use of C. cicadae fermentation product as a safe agent in functional food. PMID:26559863

  18. A 90 day chronic toxicity study of Nigerian herbal preparation DAS-77 in rats

    PubMed Central

    2012-01-01

    Background The herbal preparation DAS-77, used for the treatment of various ailments in Nigeria, contains the milled bark of Mangifera indica L. and root of Carica papaya L. Toxicological assessment of the preparation was carried out in this study. Methods In the acute toxicity study, DAS-77 was administered to mice p.o. up to 20 g/kg in divided doses and i.p. at 250–3000 mg/kg. Mortality within 24 h was recorded. In the chronic toxicity study, rats were treated p.o. for 90 days at doses of 80, 400 (therapeutic dose, TD) and 2000 mg/kg. By 90 days, animals were sacrificed and blood samples collected for hematological and biochemical analysis. Organs were harvested for weight determination, antioxidants and histopathological assessments. Results DAS-77 did not produce any lethality administered p.o. up to 20 g/kg in divided doses but the i.p. LD50 was 1122.0 mg/kg. At TD, DAS-77 produced significant (p < 0.05) reductions in body weight, food intake and K+, and increases in ovary weight, neutrophils and HDL, which were reversible. Histopathological presentations were generally normal. Effects at the other doses were comparable to those at TD except for reversible increases in antioxidants in the liver, kidney and testes, and sperm abnormality, and reductions in liver enzymes, sperm motility and count. Conclusions Findings in this study revealed that DAS-77 is relatively safe with the potential for enhancing in vivo antioxidant activity. However, possibly reversible side-effects include electrolyte imbalance and sterility in males. PMID:22892317

  19. A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine

    PubMed Central

    Hirka, Gábor; Glávits, Róbert; Palmer, Philip A.; Endres, John R.; Pasics Szakonyiné, Ilona

    2016-01-01

    A 90-day repeated-dose oral toxicological evaluation was conducted according to GLP and OECD guidelines on the methylurate purine alkaloid theacrine, which is found naturally in certain plants. Four groups of Hsd.Brl.Han Wistar rats (ten/sex/group) were administered theacrine by gavage doses of 0 (vehicle only), 180, 300, and 375 mg/kg bw/day. Two females and one male in the 300 and 375 mg/kg bw/day groups, respectively, died during the study. Histological examination revealed centrilobular hepatocellular necrosis as the probable cause of death. In 375 mg/kg bw/day males, slight reductions in body weight development, food consumption, and feed efficiency, decreased weight of the testes and epididymides and decreased intensity of spermatogenesis in the testes, lack or decreased amount of mature spermatozoa in the epididymides, and decreased amount of prostatic secretions were detected at the end of the three months. At 300 mg/kg bw/day, slight decreases in the weights of the testes and epididymides, along with decreased intensity of spermatogenesis in the testes, and lack or decreased amount of mature spermatozoa in the epididymides were detected in male animals. The NOAEL was considered to be 180 mg/kg bw/day, as at this dose there were no toxicologically relevant treatment-related findings in male or female animals. PMID:27635133

  20. A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine.

    PubMed

    Clewell, Amy; Hirka, Gábor; Glávits, Róbert; Palmer, Philip A; Endres, John R; Murbach, Timothy S; Marx, Tennille; Pasics Szakonyiné, Ilona

    2016-01-01

    A 90-day repeated-dose oral toxicological evaluation was conducted according to GLP and OECD guidelines on the methylurate purine alkaloid theacrine, which is found naturally in certain plants. Four groups of Hsd.Brl.Han Wistar rats (ten/sex/group) were administered theacrine by gavage doses of 0 (vehicle only), 180, 300, and 375 mg/kg bw/day. Two females and one male in the 300 and 375 mg/kg bw/day groups, respectively, died during the study. Histological examination revealed centrilobular hepatocellular necrosis as the probable cause of death. In 375 mg/kg bw/day males, slight reductions in body weight development, food consumption, and feed efficiency, decreased weight of the testes and epididymides and decreased intensity of spermatogenesis in the testes, lack or decreased amount of mature spermatozoa in the epididymides, and decreased amount of prostatic secretions were detected at the end of the three months. At 300 mg/kg bw/day, slight decreases in the weights of the testes and epididymides, along with decreased intensity of spermatogenesis in the testes, and lack or decreased amount of mature spermatozoa in the epididymides were detected in male animals. The NOAEL was considered to be 180 mg/kg bw/day, as at this dose there were no toxicologically relevant treatment-related findings in male or female animals. PMID:27635133

  1. A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine

    PubMed Central

    Hirka, Gábor; Glávits, Róbert; Palmer, Philip A.; Endres, John R.; Pasics Szakonyiné, Ilona

    2016-01-01

    A 90-day repeated-dose oral toxicological evaluation was conducted according to GLP and OECD guidelines on the methylurate purine alkaloid theacrine, which is found naturally in certain plants. Four groups of Hsd.Brl.Han Wistar rats (ten/sex/group) were administered theacrine by gavage doses of 0 (vehicle only), 180, 300, and 375 mg/kg bw/day. Two females and one male in the 300 and 375 mg/kg bw/day groups, respectively, died during the study. Histological examination revealed centrilobular hepatocellular necrosis as the probable cause of death. In 375 mg/kg bw/day males, slight reductions in body weight development, food consumption, and feed efficiency, decreased weight of the testes and epididymides and decreased intensity of spermatogenesis in the testes, lack or decreased amount of mature spermatozoa in the epididymides, and decreased amount of prostatic secretions were detected at the end of the three months. At 300 mg/kg bw/day, slight decreases in the weights of the testes and epididymides, along with decreased intensity of spermatogenesis in the testes, and lack or decreased amount of mature spermatozoa in the epididymides were detected in male animals. The NOAEL was considered to be 180 mg/kg bw/day, as at this dose there were no toxicologically relevant treatment-related findings in male or female animals.

  2. 21 CFR 60.34 - FDA action on petitions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 1 2013-04-01 2013-04-01 false FDA action on petitions. 60.34 Section 60.34 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PATENT TERM RESTORATION Due Diligence Petitions § 60.34 FDA action on petitions. (a) Within 90 days after FDA receives a petition filed under § 60.30(a),...

  3. Zinc oxide nanoparticles: a 90-day repeated-dose dermal toxicity study in rats

    PubMed Central

    Ryu, Hwa Jung; Seo, Mu Yeb; Jung, Sung Kyu; Maeng, Eun Ho; Lee, Seung-Young; Jang, Dong-Hyouk; Lee, Taek-Jin; Jo, Ki-Yeon; Kim, Yu-Ri; Cho, Kyu-Bong; Kim, Meyoung-Kon; Lee, Beom Jun; Son, Sang Wook

    2014-01-01

    Zinc oxide (ZnO) works as a long-lasting, broad-spectrum physical sunblock, and can prevent skin cancer, sunburn, and photoaging. Nanosized ZnO particles are used often in sunscreens due to consumer preference over larger sizes, which appear opaque when dermally applied. Although the US Food and Drug Administration approved the use of nanoparticles (NPs) in sunscreens in 1999, there are ongoing safety concerns. The aim of this study was to evaluate the subchronic toxicity of ZnO NPs after dermal application according to the Organization for Economic Cooperation and Development Test Guidelines 411 using Good Laboratory Practice. Sprague Dawley rats were randomly divided into eight (one control, one vehicle control, three experimental, and three recovery) groups. Different concentrations of ZnO NPs were dermally applied to the rats in the experimental groups for 90 days. Clinical observations as well as weight and food consumption were measured and recorded daily. Hematology and biochemistry parameters were determined. Gross pathologic and histopathologic examinations were performed on selected tissues from all animals. Analyses of tissue were undertaken to determine target organ tissue distribution. There was no increased mortality in the experimental group. Although there was dose-dependent irritation at the site of application, there were no abnormal findings related to ZnO NPs in other organs. Increased concentrations of ZnO in the liver, small intestine, large intestine, and feces were thought to result from oral ingestion of ZnO NPs via licking. Penetration of ZnO NPs through the skin seemed to be limited via the dermal route. This study demonstrates that there was no observed adverse effect of ZnO NPs up to 1,000 mg/kg body weight when they are applied dermally. PMID:25565832

  4. Zinc oxide nanoparticles: a 90-day repeated-dose dermal toxicity study in rats.

    PubMed

    Ryu, Hwa Jung; Seo, Mu Yeb; Jung, Sung Kyu; Maeng, Eun Ho; Lee, Seung-Young; Jang, Dong-Hyouk; Lee, Taek-Jin; Jo, Ki-Yeon; Kim, Yu-Ri; Cho, Kyu-Bong; Kim, Meyoung-Kon; Lee, Beom Jun; Son, Sang Wook

    2014-01-01

    Zinc oxide (ZnO) works as a long-lasting, broad-spectrum physical sunblock, and can prevent skin cancer, sunburn, and photoaging. Nanosized ZnO particles are used often in sunscreens due to consumer preference over larger sizes, which appear opaque when dermally applied. Although the US Food and Drug Administration approved the use of nanoparticles (NPs) in sunscreens in 1999, there are ongoing safety concerns. The aim of this study was to evaluate the subchronic toxicity of ZnO NPs after dermal application according to the Organization for Economic Cooperation and Development Test Guidelines 411 using Good Laboratory Practice. Sprague Dawley rats were randomly divided into eight (one control, one vehicle control, three experimental, and three recovery) groups. Different concentrations of ZnO NPs were dermally applied to the rats in the experimental groups for 90 days. Clinical observations as well as weight and food consumption were measured and recorded daily. Hematology and biochemistry parameters were determined. Gross pathologic and histopathologic examinations were performed on selected tissues from all animals. Analyses of tissue were undertaken to determine target organ tissue distribution. There was no increased mortality in the experimental group. Although there was dose-dependent irritation at the site of application, there were no abnormal findings related to ZnO NPs in other organs. Increased concentrations of ZnO in the liver, small intestine, large intestine, and feces were thought to result from oral ingestion of ZnO NPs via licking. Penetration of ZnO NPs through the skin seemed to be limited via the dermal route. This study demonstrates that there was no observed adverse effect of ZnO NPs up to 1,000 mg/kg body weight when they are applied dermally. PMID:25565832

  5. 49 CFR 24.402 - Replacement housing payment for 90-day occupants.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... occupied the displacement dwelling for at least 90 days immediately prior to the initiation of negotiations... or she moves from the displacement dwelling; or (ii) For an owner-occupant, the later of: (A) The date he or she receives final payment for the displacement dwelling, or in the case of...

  6. 49 CFR 24.402 - Replacement housing payment for 90-day occupants.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... occupied the displacement dwelling for at least 90 days immediately prior to the initiation of negotiations... or she moves from the displacement dwelling; or (ii) For an owner-occupant, the later of: (A) The date he or she receives final payment for the displacement dwelling, or in the case of...

  7. Safety assessment of meat from transgenic cattle by 90-day feeding study in rats.

    PubMed

    Liu, Shan; Li, Chen-Xi; Feng, Xiao-Lian; Wang, Hui-Ling; Liu, Hai-Bo; Zhi, Yuan; Geng, Gui-Ying; Zhao, Jie; Xu, Hai-Bin

    2013-07-01

    The study was carried out to evaluate the subchronic toxicity of meat derived from human lactoferrin gene-modified cattle in male and female Wistar rats. Rats were fed 5% or 10% transgenic meat diet, 5% or 10% conventional meat diet, or AIN93G diet for 90 days. During the study, body weight and food consumption were weighed weekly and clinical observations were conducted daily. At the end of the study, urinary examination, hematology and blood biochemistry examination, macroscopic and microscopic examinations were performed. There were no biologically significant differences in these factors between the rat groups fed transgenic meat diet and conventional meat diet. Therefore, the present 90-day rodent feeding study suggests that meat derived from the transgenic cattle is equivalent to meat from conventional cattle in use as dietary supplements.

  8. 12 CFR 220.117 - Exception to 90-day rule in special cash account.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... the language and intent of the above-quoted exception in § 220.4(c)(8), until it has been honored by... substantially the same as language found in section 4(f) of Regulation T as originally promulgated in 1934. The language of the subject exception to the 90-day rule of § 220.4(c)(8), i.e., the exception based...

  9. A 90-day safety study of genetically modified rice expressing Cry1Ab protein (Bacillus thuringiensis toxin) in Wistar rats.

    PubMed

    Schrøder, Malene; Poulsen, Morten; Wilcks, Andrea; Kroghsbo, Stine; Miller, Andreas; Frenzel, Thomas; Danier, Jürgen; Rychlik, Michael; Emami, Kaveh; Gatehouse, Angharad; Shu, Qingyao; Engel, Karl-Heinz; Altosaar, Illimar; Knudsen, Ib

    2007-03-01

    An animal model for safety assessment of genetically modified foods was tested as part of the SAFOTEST project. In a 90-day feeding study on Wistar rats, the transgenic KMD1 rice expressing Cry1Ab protein was compared to its non-transgenic parental wild type, Xiushui 11. The KMD1 rice contained 15mg Bt toxin/kg and based on the average feed consumption the daily intake was 0.54mg Bt toxin/kg body weight. No adverse effects on animal behaviour or weight gain were observed during the study. Blood samples collected one week prior to sacrifice were analyzed and compared for standard haematological and biochemical parameters. A few parameters were significantly different, but all within the normal reference intervals for rats of this breed and age and not in relation to any other findings, thus not considered treatment related. Upon sacrifice a large number of organs were weighed, macroscopic and histopathological examinations were performed with only minor changes to report. The aim of the study was to use a known animal model in performance of safety assessment of a GM crop, in this case KMD1 rice. The results show no adverse or toxic effects of KMD1 rice when tested in the design used in this 90-day study. Nevertheless the experiences from this study lead to the overall conclusion that safety assessment for unintended effects of a GM crop cannot be done without additional test group(s).

  10. A 90-day subchronic oral toxicity study of triterpene-enriched extract from Alismatis Rhizoma in rats.

    PubMed

    Huang, Ming-Qing; Xu, Wen; Wu, Shui-Shen; Lu, Jin-Jian; Chen, Xiu-Ping

    2013-08-01

    Alismatis Rhizoma has been used in East Asia as a traditional treatment for various illnesses and symptoms, and the presence of protostane-type triterpenes has been claimed to provide health benefits. To investigate the subchronic toxicity of triterpene-enriched extract from Alismatis Rhizoma (TEAR), a 90-day oral toxicity study was conducted in rats. Sprague-Dawley rats were randomly divided into four groups (10 rats/sex/group) and received doses of 0, 360, 720, and 1440 mg/kg/d of TEAR for 90 days. Daily clinical observations as well as weekly measurement of body weight and food consumption were conducted. Blood samples were obtained on day 91 to measure changes in hematology and biochemistry. Urine samples were collected on days 0 and 91 for urinalysis. At necropsy, selected organs were weighed and recorded, and histological examination was performed. No mortality or obvious treatment-related clinical signs, hematology, urinalysis parameters, and macroscopic or microscopic examinations were observed. Differences in weight gain, food consumption, biochemistry, and relative organ weight between the treated group and the control group were not considered treatment-related. On the basis of these findings, the no-observed-adverse-effect level for TEAR was 1440 mg/kg/d in both sexes. PMID:23684999

  11. A 90-day subchronic toxicity study with sodium formononetin-3'-sulphonate (Sul-F) delivered to dogs via intravenous administration.

    PubMed

    Li, Chunmei; Li, Guisheng; Gao, Yonglin; Sun, Chengfeng; Wang, Xiaoyan

    2016-06-01

    Sodium formononetin-3'-sulphonate (Sul-F) is a water-soluble derivate of formononetin, and an increasing number of studies have shown that Sul-F not only possesses favorable water solubility but also exhibits good lipid-lowering and bioactivities. In the current study, the toxicity of Sul-F was evaluated in dogs after 90-day intravenous infusion. Dogs were treated with Sul-F at dose of 0, 33.3, 100, and 300 mg/kg, and observed for 90-day followed by 28-day recovery period. Weekly measurement of body weight, temperature and food consumption were conducted. Ophthalmoscopy, ECG examination, urinalysis, serum biochemistry and hematology examination were performed at pre-test, on days 45 and 90, and following by 28-day recovery period. Histological examination was performed on day 90 and 28-day recovery period. No mortality, ophthalmic abnormalities or treatment-related findings in body weight, clinical chemistry, hematology, and histopathological examination were detected. However, a white crystal (non-metabolic Sul-F), transient vomiting and recoverable vascular stimulation were observed in 300 mg/kg/day Sul-F treated dogs. Under the conditions, the no-observed-adverse-effect-level (NOAEL) for Sul-F was 100 mg/kg in dogs.

  12. Safety assessment of EPA-rich oil produced from yeast: Results of a 90-day subchronic toxicity study.

    PubMed

    MacKenzie, Susan A; Belcher, Leigh A; Sykes, Greg P; Frame, Steven R; Mukerji, Pushkor; Gillies, Peter J

    2010-12-01

    The safety of eicosapentaenoic acid (EPA) oil produced from genetically modified Yarrowia lipolytica yeast was evaluated following 90 days of exposure. Groups of rats received 0 (olive oil), 98, 488, or 976 mg EPA/kg/day, or GRAS fish oil or deionized water by oral gavage. Rats were evaluated for in-life, neurobehavioral, anatomic and clinical pathology parameters. Lower serum cholesterol (total and non-HDL) was observed in Medium and High EPA and fish oil groups. Lower HDL was observed in High EPA and fish oil males, only at early time points. Liver weights were increased in High EPA and Medium EPA (female only) groups with no associated clinical or microscopic pathology findings. Nasal lesions, attributed to oil in the nasal cavity, were observed in High and Medium EPA and fish oil groups. No other effects were attributed to test oil exposure. Exposure to EPA oil for 90 days produced no effects at 98 mg EPA/kg/day and no adverse effects at doses up to 976 mg EPA/kg/day. The safety profile of EPA oil was comparable to that of GRAS fish oil. These results support the use of EPA oil produced from yeast as a safe source for use in dietary supplements.

  13. The impact of 90-day prescriptions on adherence at workplace pharmacies compared to traditional mail order.

    PubMed

    Patwardhan, Avinash; Davis, Jeffery; Murphy, Patricia; Khandelwal, Nikhil; Sherman, Bruce; Manfred, James

    2011-12-01

    This study evaluated adherence to medications used to treat chronic conditions for patients with 90-day prescriptions, comparing patients with access to workplace pharmacy services versus patients using mail order services. De-identified pharmacy claims data were used to compute medication possession ratio and gaps in therapy. Results were compared for patients who filled 90-day prescriptions at workplace pharmacies versus patients who filled 90-day prescriptions using mail order pharmacy services in a 1-year period. Statistical tests to assess between group differences were performed controlling for differences because of age, sex, number of select chronic conditions, number of unique medication therapeutic classes, and patient out-of-pocket cost per therapy day. Statistically significant differences were found between patients who filled their maintenance medications at the worksite compared to those who used mail-order pharmacy services. Patients filling prescriptions at a workplace pharmacy were 22% less likely to have a gap in therapy of over 30 days compared to similar patients using mail order services. Workplace pharmacy utilizers also had overall adherence rates 3.68% higher than patients who utilized mail order pharmacy services. Our analysis suggests that it may not be just the quantity of medication dispensed that impacts patients' adherence to their prescription medication, but a variety of other factors including pharmacist-patient interaction. Having a pharmacist on-site and available to patients with chronic considerations could provide added value. These results can aid employers and other stakeholders to decide which prescription benefits to offer their employees and members. PMID:22092153

  14. A 90-day study of three bruchid-resistant mung bean cultivars in Sprague-Dawley rats.

    PubMed

    Yao, Yang; Cheng, Xuzhen; Ren, Guixing

    2015-02-01

    Mung bean has been traditionally and widely used as an edible and medicinal plant in the South and Southeast Asia. Bruchid resistance mung bean has more potential in commercial use, but scarcely been evaluated for safety through standard in vivo toxicological studies. In the present study, subchronic oral toxicity studies of bruchid-resistant mung bean were designed and conducted in Sprague-Dawley (SD) rats for 90 days. During the subchronic oral toxicity study, no mortality and toxicologically significant changes in clinical signs, food consumption, opthalmoscopic examination, hematology, clinical biochemistry, macroscopic findings, organ weights and histopathological examination were noted in animal administered diet containing bruchid-resistant mung bean. These results demonstrated that bruchid resistant mung bean is as safe as conventional mung bean.

  15. 90-day dietary toxicity study with esterified propoxylated glycerol (EPG) in rats.

    PubMed

    Christian, Brian J; Bechtel, David H

    2014-12-01

    The subchronic (90-day) toxicity of a "core" version of EPG was assessed in rats. Crl:CD-1®(ICR)BR rats (70/sex) received diets containing a constant level of 5% EPG (w/w) or adjusted to deliver 0 (control), 0.5, 1, or 2g/kg of body weight/day (g/kg bw/day). Subsets of animals from each group (20/sex) were evaluated after 30 days (interim sacrifice); the remainder after 90 days. EPG intake at all dose levels was associated with lower mean liver vitamin E levels; liver vitamin A and serum vitamin D were also lower, but less consistently. Animals given 5% EPG had higher fecal output (males) and cholesterol (males and females) without corresponding changes in serum cholesterol. Urinary pH was also mildly lower in males given 5% EPG. However, detailed evaluation of general health and assessment of blood, organs and tissues showed no evidence that EPG administration compromised the nutritional requirements of the animals, caused a state of fat-soluble vitamin deficiency, or caused' toxicity to any organ system. Based on the results of this study, it was not possible to establish a no-observable-effect level (NOEL). The possible effect of EPG on vitamin levels in the absence of any clinical signs of deficiency was not considered "adverse" per se. As such, the 2g/kg and 5% EPG level were considered to represent a no-observable-adverse-effect levels (NOAELs). PMID:25497991

  16. Pulmonary toxicity of simulated lunar and Martian dusts in mice: I. Histopathology 7 and 90 days after intratracheal instillation.

    PubMed

    Lam, Chiu-Wing; James, John T; McCluskey, Richard; Cowper, Shawn; Balis, John; Muro-Cacho, Carlos

    2002-09-01

    NASA is contemplating sending humans to Mars and to the moon for further exploration. Volcanic ashes from Arizona and Hawaii with mineral properties similar to those of lunar and Martian soils, respectively, are used to simulate lunar and Martian environments for instrument testing. Martian soil is highly oxidative; this property is not found in Earth's volcanic ashes. NASA is concerned about the health risk from potential exposure of workers in the test facilities. Fine lunar soil simulant (LSS), Martian soil simulant (MSS), titanium dioxide, or quartz in saline was intratracheally instilled into groups of 4 mice (C57BL/6J) at 0.1 mg/mouse (low dose, LD) or 1 mg/mouse (high dose, HD). Separate groups of mice were exposed to ozone (0.5 ppm for 3 h) prior to MSS instillation. Lungs were harvested for histopathological examination 7 or 90 days after the single dust treatment. The lungs of the LSS-LD groups showed no evidence of inflammation, edema, or fibrosis; clumps of particles and an increased number of macrophages were visible after 7 days but not 90 days. In the LSS-HD-7d group, the lungs showed mild to moderate alveolitis, and perivascular and peribronchiolar inflammation. The LSS-HD-90d group showed signs of mild chronic pulmonary inflammation, septal thickening, and some fibrosis. Foci of particle-laden macrophages (PLMs) were still visible. Lung lesions in the MSS-LD-7d group were similar to those observed in the LSS-HD-7d group. The MSS-LD-90d group had PLMs and scattered foci of mild fibrosis in the lungs. The MSS-HD-7d group showed large foci of PLMs, intra-alveolar debris, mild-to-moderate focal alveolitis, and perivascular and peribronchiolar inflammation. The MSS-HD-90d group showed focal chronic mild-to-moderate alveolitis and fibrosis. The findings in the O(3)-MSS-HD-90d group included widespread intra-alveolar debris, focal moderate alveolitis, and fibrosis. Lung lesions in the MSS groups were more severe with the ozone pretreatment. The effects of

  17. Pulmonary toxicity of simulated lunar and Martian dusts in mice: I. Histopathology 7 and 90 days after intratracheal instillation

    NASA Technical Reports Server (NTRS)

    Lam, Chiu-Wing; James, John T.; McCluskey, Richard; Cowper, Shawn; Balis, John; Muro-Cacho, Carlos

    2002-01-01

    NASA is contemplating sending humans to Mars and to the moon for further exploration. Volcanic ashes from Arizona and Hawaii with mineral properties similar to those of lunar and Martian soils, respectively, are used to simulate lunar and Martian environments for instrument testing. Martian soil is highly oxidative; this property is not found in Earth's volcanic ashes. NASA is concerned about the health risk from potential exposure of workers in the test facilities. Fine lunar soil simulant (LSS), Martian soil simulant (MSS), titanium dioxide, or quartz in saline was intratracheally instilled into groups of 4 mice (C57BL/6J) at 0.1 mg/mouse (low dose, LD) or 1 mg/mouse (high dose, HD). Separate groups of mice were exposed to ozone (0.5 ppm for 3 h) prior to MSS instillation. Lungs were harvested for histopathological examination 7 or 90 days after the single dust treatment. The lungs of the LSS-LD groups showed no evidence of inflammation, edema, or fibrosis; clumps of particles and an increased number of macrophages were visible after 7 days but not 90 days. In the LSS-HD-7d group, the lungs showed mild to moderate alveolitis, and perivascular and peribronchiolar inflammation. The LSS-HD-90d group showed signs of mild chronic pulmonary inflammation, septal thickening, and some fibrosis. Foci of particle-laden macrophages (PLMs) were still visible. Lung lesions in the MSS-LD-7d group were similar to those observed in the LSS-HD-7d group. The MSS-LD-90d group had PLMs and scattered foci of mild fibrosis in the lungs. The MSS-HD-7d group showed large foci of PLMs, intra-alveolar debris, mild-to-moderate focal alveolitis, and perivascular and peribronchiolar inflammation. The MSS-HD-90d group showed focal chronic mild-to-moderate alveolitis and fibrosis. The findings in the O(3)-MSS-HD-90d group included widespread intra-alveolar debris, focal moderate alveolitis, and fibrosis. Lung lesions in the MSS groups were more severe with the ozone pretreatment. The effects of

  18. 75 FR 6437 - Endangered and Threatened Wildlife and Plants; 12-month Finding on a Petition to List the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-09

    ..., 2009 (74 FR 21301), we reviewed the petition, petition supplement, supporting information provided by... Laramie, Wasatch, and Black Hills (Wyoming Game and Fish Department (WGFD) 2009, p. 1). American pikas are... sites throughout much of the State (Idaho Department of Fish and Game (IDFG) 2009, p. 1). The IDFG...

  19. A 90-Day Toxicology Study of Meat from Genetically Modified Sheep Overexpressing TLR4 in Sprague-Dawley Rats

    PubMed Central

    Hu, Rui; Kan, Tongtong; Li, Yan; Zhang, Xiaosheng; Zhang, Jinlong; Lian, Ling; Han, Hongbing; Lian, Zhengxing

    2015-01-01

    Genetic modification offers alternative strategies to traditional animal breeding. However, the food safety of genetically modified (GM) animals has attracted increasing levels of concern. In this study, we produced GM sheep overexpressing TLR4, and the transgene-positive offsprings (F1) were confirmed using the polymerase chain reaction (PCR) and Southern blot. The expression of TLR4 was 2.5-fold compared with that of the wild-type (WT) sheep samples. During the 90-day safety study, Sprague-Dawley rats were fed with three different dietary concentrations (3.75%, 7.5%, and 15% wt/wt) of GM sheep meat, WT sheep meat or a commercial diet (CD). Blood samples from the rats were collected and analyzed for hematological and biochemical parameters, and then compared with hematological and biochemical reference ranges. Despite a few significant differences among the three groups in some parameters, all other values remained within the normal reference intervals and thus were not considered to be affected by the treatment. No adverse diet-related differences in body weights or relative organ weights were observed. Furthermore, no differences were observed in the gross necropsy findings or microscopic pathology of the rats whose diets contained the GM sheep meat compared with rats whose diets contained the WT sheep meat. Therefore, the present 90-day rat feeding study suggested that the meat of GM sheep overexpressing TLR4 had no adverse effect on Sprague-Dawley rats in comparison with WT sheep meat. These results provide valuable information regarding the safety assessment of meat derived from GM animals. PMID:25874566

  20. A 90-day toxicology study of meat from genetically modified sheep overexpressing TLR4 in Sprague-Dawley rats.

    PubMed

    Bai, Hai; Wang, Zhixian; Hu, Rui; Kan, Tongtong; Li, Yan; Zhang, Xiaosheng; Zhang, Jinlong; Lian, Ling; Han, Hongbing; Lian, Zhengxing

    2015-01-01

    Genetic modification offers alternative strategies to traditional animal breeding. However, the food safety of genetically modified (GM) animals has attracted increasing levels of concern. In this study, we produced GM sheep overexpressing TLR4, and the transgene-positive offsprings (F1) were confirmed using the polymerase chain reaction (PCR) and Southern blot. The expression of TLR4 was 2.5-fold compared with that of the wild-type (WT) sheep samples. During the 90-day safety study, Sprague-Dawley rats were fed with three different dietary concentrations (3.75%, 7.5%, and 15% wt/wt) of GM sheep meat, WT sheep meat or a commercial diet (CD). Blood samples from the rats were collected and analyzed for hematological and biochemical parameters, and then compared with hematological and biochemical reference ranges. Despite a few significant differences among the three groups in some parameters, all other values remained within the normal reference intervals and thus were not considered to be affected by the treatment. No adverse diet-related differences in body weights or relative organ weights were observed. Furthermore, no differences were observed in the gross necropsy findings or microscopic pathology of the rats whose diets contained the GM sheep meat compared with rats whose diets contained the WT sheep meat. Therefore, the present 90-day rat feeding study suggested that the meat of GM sheep overexpressing TLR4 had no adverse effect on Sprague-Dawley rats in comparison with WT sheep meat. These results provide valuable information regarding the safety assessment of meat derived from GM animals.

  1. Program operational summary: Operational 90 day manned test of a regenerative life support system

    NASA Technical Reports Server (NTRS)

    Jackson, J. K.; Wamsley, J. R.; Bonura, M. S.; Seeman, J. S.

    1972-01-01

    An operational 90-day manned test of a regenerative life support system was successfully completed. This test was performed with a crew of four carefully selected and trained men in a space station simulator (SSS) which had a two gas atmosphere maintained at a total pressure of 68.9, 10 psia, and composed of oxygen at a partial pressure of 3.05 psia with nitrogen as the diluent. The test was planned to provide data on regenerative life support subsystems and on integrated system operations in a closed ecology, similar to that of a space station. All crew equipment and expendables were stored onboard at the start of the mission to eliminate the need for pass-in operations. The significant accomplishments of the test, some of the pertinent test results, some of the problem areas, and conclusions are presented.

  2. Ultrastructural response of rat lung to 90 days' exposure to oxygen at 450 mm Hg

    NASA Technical Reports Server (NTRS)

    Harrison, G. A.

    1974-01-01

    Young Sprague-Dawley rats were exposed to 100% oxygen at 450 mm Hg in constant environment capsules for 90 days. Lung tissue examined by electron microscopy revealed a number of changes, many similar to those observed after exposure to oxygen at 760 mm Hg for shorter periods of time. Alterations in vesicle size and number and in mitochondrial matrix and cristae appear in both the endothelial and epithelial cells. Blebbing and rarefication of cytoplasm occur in both cell layers of the alveolo-capillary wall. Also seen are fluid in the basement membrane, platelets in the capillaries, and alveolar fluid and debris. All of these alterations occur at 1 atm exposure. However, after exposure to 450 mm Hg the changes are not as widespread nor as destructive as they are at the higher pressure.

  3. Training plan for the 1164 {lt}90-day non-radioactive hazardous waste storage building

    SciTech Connect

    Demarest, J.L., Westinghouse Hanford

    1996-07-01

    In accordance with Washington Administrative Code (WAC), Chapter 173- 303, `Dangerous Waste Regulations,` a written training plan is required for a {lt}90-day accumulation area. WAC 173-303-200, `Accumulating Dangerous Waste On-site,` requires compliance with WAC- 173-303-330, Personnel Training. This training plan complies with WAC 173-303-330. This training plan, including the names of personnel in Table 1, may be given to a regulatory agency inspector upon request provided that this plan is cleared for public release. Training records associated with personnel identified in this plan are not be given to an outside regulatory agency inspector unless prior approval by the specific individual is obtained. Training records requests by regulatory agency inspectors without the individual`s approval are to be processed via a Freedom of Information Act request through the U.S. Department of Energy, Richland Operations Office.

  4. Co-morbidities and 90-day outcomes in hospitalized COPD exacerbations.

    PubMed

    Roberts, Christopher M; Stone, Robert A; Lowe, Derek; Pursey, Nancy A; Buckingham, Rhona J

    2011-10-01

    COPD exacerbations resulting in hospitalization are accompanied by high mortality and morbidity. The contribution of specific co-morbidities to acute outcomes is not known in detail: existing studies have used either administrative data or small clinical cohorts and have provided conflicting results. Identification of co-existent diseases that affect outcomes provides opportunities to address these conditions proactively and improve overall COPD care. Cases were identified prospectively on admission then underwent retrospective case note audit to collect data including co-morbidities on up to 60 unselected consecutive acute COPD admissions between March and May in each hospital participating in the 2008 UK National COPD audit. Outcomes recorded were death in hospital, length of stay, and death and readmission at 90 days after index admission. 232 hospitals collected data on 9716 patients, mean age 73, 50% male, mean FEV1 42% predicted. Prevalence of co-morbidities were associated with increased age but better FEV1 and ex-smoker status and with worse outcomes for all four measures. Hospital mortality risk was increased with cor pulmonale, left ventricular failure, neurological conditions and non-respiratory malignancies whilst 90 day death was also increased by lung cancer and arrhythmias. Ischaemic and other heart diseases were important factors in readmission. This study demonstrates that co-morbidities adversely affect a range of short-term patient outcomes related to acute admission to hospital with exacerbations of COPD. Recognition of relevant accompanying diseases at admission provides an opportunity for specific interventions that may improve short-term prognosis. PMID:21864116

  5. Bioregenerative Life Support Experiment for 90-days in a Closed Integrative Experimental Facility LUNAR PALACE 1

    NASA Astrophysics Data System (ADS)

    Liu, Hong

    A 90-day bioregenerative life support experiment with three-member crew was carried out in the closed integrative experimental facility, LUNAR PALACE 1 regenerating basic living necessities and disposing wastes to provide life support for crew. It was composed of higher plant module, animal module, and waste treatment module. The higher plant module included wheat, chufa, pea, carrot and green leafy vegetables, with aim to satisfy requirement of 60% plant food and 100% O2 and water for crew. The yellow mealworm was selected as animal module to provide partial animal protein for crew, and reared on plant inedible biomass. The higher plant and yellow mealworm were both cultivated and harvested in the conveyor-type manner. The partial plant inedible biomass and human feces were mixed and co- fermented in the waste treatment module for preparation of soil-like substrate by bioconversion, maintaining gas balance and increasing closure degree. Meanwhile, in the waste treatment module, the water and partial nitrogen from human urine were recovered by physical-chemical means. Circulation of O2 and water as well as food supply from crops cultivated in the LUNAR PALACE 1 were investigated and calculated, and simultaneously gas exchange, mass flow among different components and system closure degree were also analyzed, respectively. Furthermore, the system robustness with respect to internal variation was tested and evaluated by sensitivity analysis of the aggregative index consisting of key performance indicators like crop yield, gaseous equilibrium concentration, microbial community composition, biogenic elements dynamics, etc., and comprehensively evaluating the operating state, to number change of crew from 2 to 4 during the 90-day closed experiment period.

  6. 77 FR 52650 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the Platte...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-30

    ... for 38 of the petition's 206 species in the Federal Register (74 FR 41649) on August 18, 2009; the... potential predators of the caddisfly, such as fish and amphibians, thereby reducing larval densities...

  7. 78 FR 18936 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-28

    .... On November 10, 2010, we included the Rosemont talussnail in the annual CNOR (75 FR 69222) through..., invertebrates are precluded by statute from DPS consideration. Therefore, we conclude that the petitioned...

  8. 76 FR 23649 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition and Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-27

    ... the Act via a rule published in the Federal Register on June 2, 1970 (35 FR 8491). Import into, export... FR 36743), stated that the petition provided substantial information to indicate that the...

  9. A 90-day subchronic toxicity study of neem oil, a Azadirachta indica oil, in mice.

    PubMed

    Wang, C; Cao, M; Shi, D-X; Yin, Z-Q; Jia, R-Y; Wang, K-Y; Geng, Y; Wang, Y; Yao, X-P; Yang, Z-R; Zhao, J

    2013-09-01

    To determine the no-observed-adverse-effect level (NOAEL) of exposure and target organs of neem oil for establishing safety criteria for human exposure, the subchronic toxicity study with neem oil in mice was evaluated. The mice (10 per sex for each dose) was orally administered with neem oil with the doses of 0 (to serve as a control), 177, 533 and 1600 mg/kg/day for 90 days. After the treatment period, observation of reversibility or persistence of any toxic effects, mice were continuously fed without treatment for the following 30 days. During the two test periods, the serum biochemistry, organ weight and histopathology were examined. The results showed that the serum biochemistry and organ coefficient in experimental groups had no statistical difference compared with those of the control group. At the 90th day, the histopathological examinations showed that the 1600 mg/kg/day dose of neem oil had varying degrees of damage on each organ except heart, uterus and ovarian. After 30-day recovery, the degree of lesions to the tissues was lessened or even restored. The NOAEL of neem oil was 177 mg/kg/day for mice and the target organs of neem oil were determined to be testicle, liver and kidneys.

  10. 90-day dermal toxicity study and neurotoxicity evaluation of nitromusks in the albino rat.

    PubMed

    Ford, R A; Api, A M; Newberne, P M

    1990-01-01

    Musk ketone, musk xylene, musk tibetene and moskene, synthetic musks used in fragrances, were applied dermally to rats in daily doses of 240 (musk ketone and musk xylene only), 75, 24 or 7.5 mg/kg body weight for 90 days. The chemically related musk ambrette, a known neurotoxin in rats, was used as a positive control. While musk ambrette was clearly neurotoxic and caused testicular atrophy, as had been previously reported, the other compounds tested caused neither effect. The only effects of application of these materials were some organ weight changes at the higher doses, but these were not associated with histopathological changes in any of the tissues. The no-effect levels were: musk ketone, 75 mg/kg for males and females; musk xylene, 75 mg/kg for males and 24 mg/kg for females; moskene, 24 mg/kg for males and 75 mg/kg (highest dose administered) for females; and musk tibetene, 75 mg/kg (highest dose) for males and females.

  11. Safety assessment of dietary bamboo charcoal powder: a 90-day subchronic oral toxicity and mutagenicity studies.

    PubMed

    Zhenchao, Jia; Yuting, Zhong; Jiuming, Yan; Yedan, Lu; Yang, Song; Jinyao, Chen; Lishi, Zhang

    2015-01-01

    Vegetable carbon has been used as food additive in EU (E153) and China for many years; however, no experimental data have been available on its dietary safety. This study was designed to evaluate the subchronic toxicity and genotoxicity of bamboo charcoal powder (BCP). In the study of subchronic oral toxicity, BCP was administered orally at doses of 2.81, 5.62, and 11.24 g/kg BW for 90 days to SD rats. Additional satellite groups from the control group and high dose group were observed for a 28-day recovery period. At the end of the treatment and recovery periods, animals were sacrificed, and their organs were weighed and blood samples were collected. The toxicological endpoints observed included clinical signs, food consumption, body and organ weights, hematological and biochemical parameters, macroscopic and microscopic examinations. The results showed no significant differences between the BCP treated groups and control group. The genotoxicity of BCP was assessed with the Salmonella typhimurium mutagenicity assay (Ames test) and a combination of comet assay and mammalian erythrocyte micronucleus protocol. The results did not reveal any genotoxicity of BCP. Based on our study, the no-observed-adverse-effect level (NOAEL) for BCP is 11.24 g/kg BW/day.

  12. A 90-day subchronic toxicity study of neem oil, a Azadirachta indica oil, in mice.

    PubMed

    Wang, C; Cao, M; Shi, D-X; Yin, Z-Q; Jia, R-Y; Wang, K-Y; Geng, Y; Wang, Y; Yao, X-P; Yang, Z-R; Zhao, J

    2013-09-01

    To determine the no-observed-adverse-effect level (NOAEL) of exposure and target organs of neem oil for establishing safety criteria for human exposure, the subchronic toxicity study with neem oil in mice was evaluated. The mice (10 per sex for each dose) was orally administered with neem oil with the doses of 0 (to serve as a control), 177, 533 and 1600 mg/kg/day for 90 days. After the treatment period, observation of reversibility or persistence of any toxic effects, mice were continuously fed without treatment for the following 30 days. During the two test periods, the serum biochemistry, organ weight and histopathology were examined. The results showed that the serum biochemistry and organ coefficient in experimental groups had no statistical difference compared with those of the control group. At the 90th day, the histopathological examinations showed that the 1600 mg/kg/day dose of neem oil had varying degrees of damage on each organ except heart, uterus and ovarian. After 30-day recovery, the degree of lesions to the tissues was lessened or even restored. The NOAEL of neem oil was 177 mg/kg/day for mice and the target organs of neem oil were determined to be testicle, liver and kidneys. PMID:23444337

  13. 78 FR 20855 - State Implementation Plans: Response to Petition for Rulemaking; Findings of Substantial...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-08

    ... February 22, 2013 (78 FR 12460) must be received on or before May 13, 2013. ADDRESSES: Submit your comments...; Findings of Substantial Inadequacy; and SIP Calls To Amend Provisions Applying to Excess Emissions During...; Findings of Substantial Inadequacy; and SIP Calls to Amend Provisions Applying to Excess Emissions...

  14. 76 FR 63419 - Endangered and Threatened Wildlife and Plants; 12-Month Petition Finding, Proposed Listing of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-12

    ..., pp. 1-19). On July 8, 2009, we published in the Federal Register (74 FR 32510) our finding that the... karst (an area of limestone terrene characterized by sinks, ravines, and underground streams) zones...

  15. A-90 Day Gavage Safety Assessment of Boswellia serrata in Rats

    PubMed Central

    Singh, Pooja; Chacko, K. Mathai; Aggarwal, M. L.; Bhat, Binu; Khandal, R. K.; Sultana, Sarwat; Kuruvilla, Binu T.

    2012-01-01

    The present study deals with the evaluation and assessment of the safety/toxic potential of Boswellia serrata, a well known Ayurvedic herb used to treat disorders of digestive system, respiratory ailments and bone related diseases. A repeated dose oral (90 days) toxicity study of Boswellia serrata was carried out. For this, 10 rats of each sex were treated with the Boswellia serrata at three different doses i.e. 100, 500 and 1000 mg/kg B. wt. /day. As a control, 10 rats of each sex were treated with corn oil only which was the vehicle. Two groups consisting of five male and five female rats were kept as control recovery and high dose recovery group which were treated with the vehicle (corn oil) and the Boswellia serrata at the dose of 1000 mg/kg B. wt. Animals of control recovery and high dose recovery groups were further observed for 28 days without any treatment. From this study, it was found that the rats treated with high dose of the Boswellia serrata gained their body weight with much less rate than that of the control group. However, during the recovery period, the loss in body weight gain as observed during the study period exhibits a reversible effect on the metabolic activity and recovered. The results also indicate that Boswellia serrata is relatively safe in rat up to the dose of 500 mg/kg B.wt. as no adverse impact on health factors was observed. Thus, the No observed adverse effect level is 500 mg/kg B. wt. PMID:23293466

  16. Petroleum prices and profits in the 90 days following the invasion of Kuwait

    SciTech Connect

    Not Available

    1990-11-01

    For the third in the past 20 years the world has experienced an interruption in the flow of oil from the Persian Gulf. The Iraqi invasion of Kuwait on August 2, 1990, and shut down of Kuwait oil production capacity followed by the United Nations boycott of Iraqi oil removed 8 percent of the world's oil supply. The result was a sharp increase in the process of crude oil and petroleum products. These events raised numerous questions about the performance of energy markets and energy firms. This report supplies a first answer for some of those questions. At the time this report was prepared the invasion has been in effect for 90 days. Not all the data is available to fully answer every question. Some issues can only be completely resolved after more time has passed in which the invasion and its effects have had an opportunity to be fully assimilated. This report was specifically requested by W. Henson Moore, Deputy Secretary of Energy as a way of supplying the American public with what could be said about the current situation. Rumors abound and mixconceptions have proliferated. This report strives to give a proper perspective on some of the more vexing issues which the invasion produced. The Energy Information Administration (EIA) has addressed many questions in this report. By the way of summary these are the 10 most most frequently asked questions and EIA's quick answers. The page references tell the reader where to look in the report for further explanation. These are not the only issues addressed and EIA hopes that readers will be able to satisfy their curiosity about their own questions within the pages of this report.

  17. 78 FR 24603 - Endangered and Threatened Wildlife and Plants; Annual Notice of Findings on Resubmitted Petitions...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-25

    ... (Stiles in litt. 1999 as cited in BLI 2010b). The species inhabits the water's edge, in flooded pasture... FURTHER INFORMATION CONTACT: Chief, Branch of Foreign Species, Endangered Species Program, U.S. Fish and... findings. Since publication of the previous ANOR on May 3, 2011 (76 FR 25150), we reviewed the...

  18. 76 FR 25149 - Endangered and Threatened Wildlife and Plants; Annual Notice of Findings on Resubmitted Petitions...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-03

    ... Review published on August 12, 2009 (74 FR 40540). Based on our current review, we find that 20 species..., 2009, 74 FR 40540). We maintain this list of candidates for a variety of reasons: To notify the public... listing priority number (LPN) for each candidate species (48 FR 43098). Using this guidance, we...

  19. 77 FR 10451 - Fishing Tackle Containing Lead; Disposition of Petition Filed Pursuant to TSCA Section 21

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-22

    ... p.m., Monday through Friday, excluding legal holidays. The telephone number of the EPA/DC Public... requested. EPA is required to grant or deny the petition within 90 days of its filing. If EPA grants the... days of either a denial or the expiration of the 90-day period if EPA fails to respond within 90......

  20. Comparative 90-day dietary study of paraffin wax in Fischer-344 and Sprague-Dawley rats.

    PubMed

    Griffis, L C; Twerdok, L E; Francke-Carroll, S; Biles, R W; Schroeder, R E; Bolte, H; Faust, H; Hall, W C; Rojko, J

    2010-01-01

    Highly refined mineral hydrocarbons (MHCs) such as low melting point paraffin wax (LMPW) and low viscosity white oils can cause inflammatory changes in the liver and mesenteric lymph nodes (MLNs) of the Fischer-344 (F-344) rat. In contrast, only minimal MLN changes are seen in the Sprague-Dawley (S-D) rat with no changes in the liver. In this study, the response of female F-344 and S-D rats was compared after 90days dietary treatment with 0%, 0.2% or 2% LMPW. Effects in the F-344 rats were significantly greater than in the S-D rats: increased liver and splenic weights and inflammatory changes (hepatic microgranulomas) in these tissues were observed only in the F-344 rats. Microgranulomas in the MLNs were observed in both strains but the effects were substantially greater in the F-344 rats. Cellular markers of inflammation were examined in a subset of rats from each group using immunohistochemical staining. An increase in staining for CD3 (T-cells), CD8a (suppresser/cytotoxic T-cells) and CD4 (helper T-cells) correlated with an increase in lymphoid cells in the livers of treated F-344 rats. The majority of macrophages in the hepatic microgranulomas of treated F-344 rats were negative for the ED2 marker, indicating a likely origin from non-resident macrophages. Electron microscopy showed Kupffer cell hypertrophy and hyperplasia in treated F-344 rats. However, lysozyme staining (indicating activation of epithelioid macrophages) decreased with increasing granuloma size. Non-ED2 expressing cells may have been recruited but not sufficiently activated to be lysozyme positive. Inflammatory changes in the cardiac mitral valve noted in previous studies of LMPW were also seen in the F-344 rats in this study but not in the S-D rats. Chemical analysis showed that MHC accumulated in livers from treated F-344 but not S-D rats and the concentration was more than 2-fold greater in MLNs from the F-344 than from the S-D rats. The F-344 appears to be more immunologically sensitive to

  1. Effects of 30-, 60-, and 90-Day Bed Rest on Postural Control in Men and Women

    NASA Technical Reports Server (NTRS)

    Esteves, Julie; Taylor, Laura C.; Vanya, Robert D.; Dean, S. Lance; Wood, Scott J.

    2011-01-01

    INTRODUCTION Head-down-tilt bed rest (HDT) has been used as a safe gr ound-based analog to mimic and develop countermeasures for the physiological effects of spaceflight, including decrements in postural stability. The purpose of this investigation was to characterize the effects of 30-, 60-, and 90-day bed rest on postural control in men and women. METHODS Twenty-nine subjects (18M,11F) underwent 13 days of ambula tory acclimatization and were placed in 6? HDT for 30 (n=12), 60 (n=8), or 90 (n=9) days, followed by 14 days of ambulatory recovery. Computerized dynamic posturography (CDP) was used to assess changes in sensory and motor components of postural control, and recovery after HDT. Sensory Organization Tests (SOTs) objectively evaluate one?s ability to effectively use or suppress visual, vestibular, and proprioceptive information for postural control. Stability during the SOTs was assessed using peak-to-peak sway and convergence toward stability limits to derive an equilibrium score. Motor Control Tests (MCTs) evaluate one?s ability to recover from unexpected support surface perturbations, with performance determined by center-of-pressure path length. Whole-body kinematic data were collected to determine body-sway strategy used to maintain stability during each condition. Baselines were determined pre-HDT. Recovery was tracked post-HDT on days 0, 1, 2, and 4. RESULTS Immediately after HDT, subjects showed decreased performance on most SOTs, primarily on sway-referenced support conditions, typically returning to baseline levels within 4 days. MCT performance was not significantly affected. There were no significant gender or duration differences in performance. Kinematic data revealed a tendency to use ankle strategy to maintain an upright stance during most SOT conditions. Interestingly, six subjects (2M,4F) experienced orthostatic intolerance and were unable to complete day 0 testing. CONCLUSION HDT mimics some un loading mechanisms of spaceflight and

  2. 76 FR 47133 - Endangered and Threatened Wildlife and Plants; 90-Day Finding and 12-Month Determination on a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-04

    ... concerned. Previous Federal Actions In 1970, the leatherback sea turtle was listed as endangered (35 FR 8491... designated critical habitat for the leatherback sea turtle on March 23, 1979 (44 FR 17710), in the U.S... sea turtles may be warranted (May 5, 2011; 76 FR 25660). On February 23, 2011, the Sierra Club sent...

  3. 76 FR 61307 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List Calopogon...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-04

    ... orchid) under the Endangered Species Act of 1973, as amended. After review of the best available... is available for public inspection, by appointment, during normal business hours at the U.S. Fish and... On May 28, 2008, we received a petition dated May 22, 2008, from Dr. Douglas Goldman of the...

  4. 77 FR 29077 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To Downlist Three...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-16

    ... (42 FR 40682). Subsequently, a Recovery Plan for Channel Island species, including M. clementinus, A... FR 3069) in which we concluded that the petition and information in our files provided substantial... on May 21, 2010 (75 FR 28636). We will base our 5-year review recommendations on the information...

  5. 75 FR 30757 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition to Delist Cirsium...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-02

    ... the Act on May 16, 1984 (49 FR 20735), and listed the species on June 16, 1987 (52 FR 22933). A... the species (52 FR 22935). On April 30, 2004, we received a petition from Mr. Doug Moore, County... status review of the species (71 FR 70479; December 5, 2006). On August 13, 2007, we received a...

  6. 76 FR 63719 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List a Distinct...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-13

    ... Federal Register (73 FR 63919). We found that the petition presented substantial information indicating... among gender, age, or among voles occurring in young (22-55 years old) versus old (110-260 years old... terms appear in cited literature, or where specific ages are referred to, we refer to them in...

  7. 75 FR 51204 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To Remove the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-19

    ... Stephens' kangaroo rat as endangered on September 30, 1988 (53 FR 38465). We published a draft recovery plan for the Stephens' kangaroo rat on June 23, 1997 (62 FR 33799; Service 1997, pp. 1-71), but it has... substantial information to indicate that the petitioned action may be warranted (69 FR 21567), and...

  8. 76 FR 44547 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the Giant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-26

    ... may be warranted (72 FR 57273). On January 24, 2008, the petitioners filed a lawsuit in the U.S... habitat (75 FR 42059). Based on our review, we found the petition presented substantial scientific or... for the GPE, the Idaho Department of Fish and Game, the Service, and others have contributed...

  9. 77 FR 19597 - Listing Endangered and Threatened Species; 12-Month Finding on a Petition To List Chinook Salmon...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-02

    ... of Chinook salmon, we use the description of that ESU (Myers et al., 1998 and 63 FR 11482; March 9... substantial information indicating that the petitioned action may be warranted (76 FR 20302; April 12, 2011... of Species Under the Endangered Species Act to Pacific Salmon (ESU Policy; 56 FR 68612; November...

  10. 77 FR 66799 - Endangered and Threatened Wildlife and Plants: Notice of 12-Month Finding on a Petition To List...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-07

    ... petitioned action may be warranted (75 FR 16713). We initiated a comprehensive status review of bumphead... Listing Determinations, or PECE policy (68 FR 15100; March 28, 2003) provides direction for the... endangered or threatened depends on the specific life history and ecology of the species, the nature...

  11. 76 FR 62503 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the Black...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-07

    ... FR 57278), in which we concluded the petition presented substantial scientific or commercial... reopening of the information collection period (74 FR 43092) in response to the U.S. Geological Survey... to be 86 percent or higher to prevent a population decrease. Estimates of juvenile survivorship...

  12. 75 FR 54822 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the Jemez...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-09

    ... review classifying the salamander as a Category 2 species (47 FR 58454, December 30, 1982). Category 2... that the petition contained sufficient information to suggest that listing may be warranted (55 FR... announced the salamander as a Category 1 species with a ``declining'' status (56 FR 58814). Category...

  13. Effects of 90-Day Feeding of Transgenic Maize BT799 on the Reproductive System in Male Wistar Rats.

    PubMed

    Guo, Qian-ying; He, Li-xia; Zhu, Han; Shang, Jun-li; Zhu, Ling-yan; Wang, Jun-bo; Li, Yong

    2015-12-01

    BT799 is a genetically modified (GM) maize plant that expresses the Cry1Ac gene from Bacillus thuringiensis (Bt). The Cry1Ac gene was introduced into maize line Zhen58 to encode the Bt crystal protein and thus produce insect-resistant maize BT799. Expression of Bt protein in planta confers resistance to Lepidopteran pests and corn rootworms. The present study was designed to investigate any potential effects of BT799 on the reproductive system of male rats and evaluate the nutritional value of diets containing BT799 maize grain in a 90-day subchronic rodent feeding study. Male Wistar rats were fed with diets containing BT799 maize flours or made from its near isogenic control (Zhen58) at a concentration of 84.7%, nutritionally equal to the standard AIN-93G diet. Another blank control group of male rats were treated with commercial AIN-93G diet. No significant differences in body weight, hematology and serum chemistry results were observed between rats fed with the diets containing transgenic BT799, Zhen58 and the control in this 13-week feeding study. Results of serum hormone levels, sperm parameters and relative organ/body weights indicated no treatment-related side effects on the reproductive system of male rats. In addition, no diet-related changes were found in necropsy and histopathology examinations. Based on results of the current study, we did not find any differences in the parameters tested in our study of the reproductive system of male rats between BT799 and Zhen58 or the control. PMID:26633453

  14. Effects of 90-Day Feeding of Transgenic Maize BT799 on the Reproductive System in Male Wistar Rats.

    PubMed

    Guo, Qian-ying; He, Li-xia; Zhu, Han; Shang, Jun-li; Zhu, Ling-yan; Wang, Jun-bo; Li, Yong

    2015-12-02

    BT799 is a genetically modified (GM) maize plant that expresses the Cry1Ac gene from Bacillus thuringiensis (Bt). The Cry1Ac gene was introduced into maize line Zhen58 to encode the Bt crystal protein and thus produce insect-resistant maize BT799. Expression of Bt protein in planta confers resistance to Lepidopteran pests and corn rootworms. The present study was designed to investigate any potential effects of BT799 on the reproductive system of male rats and evaluate the nutritional value of diets containing BT799 maize grain in a 90-day subchronic rodent feeding study. Male Wistar rats were fed with diets containing BT799 maize flours or made from its near isogenic control (Zhen58) at a concentration of 84.7%, nutritionally equal to the standard AIN-93G diet. Another blank control group of male rats were treated with commercial AIN-93G diet. No significant differences in body weight, hematology and serum chemistry results were observed between rats fed with the diets containing transgenic BT799, Zhen58 and the control in this 13-week feeding study. Results of serum hormone levels, sperm parameters and relative organ/body weights indicated no treatment-related side effects on the reproductive system of male rats. In addition, no diet-related changes were found in necropsy and histopathology examinations. Based on results of the current study, we did not find any differences in the parameters tested in our study of the reproductive system of male rats between BT799 and Zhen58 or the control.

  15. Effects of 90-Day Feeding of Transgenic Maize BT799 on the Reproductive System in Male Wistar Rats

    PubMed Central

    Guo, Qian-ying; He, Li-xia; Zhu, Han; Shang, Jun-li; Zhu, Ling-yan; Wang, Jun-bo; Li, Yong

    2015-01-01

    BT799 is a genetically modified (GM) maize plant that expresses the Cry1Ac gene from Bacillus thuringiensis (Bt). The Cry1Ac gene was introduced into maize line Zhen58 to encode the Bt crystal protein and thus produce insect-resistant maize BT799. Expression of Bt protein in planta confers resistance to Lepidopteran pests and corn rootworms. The present study was designed to investigate any potential effects of BT799 on the reproductive system of male rats and evaluate the nutritional value of diets containing BT799 maize grain in a 90-day subchronic rodent feeding study. Male Wistar rats were fed with diets containing BT799 maize flours or made from its near isogenic control (Zhen58) at a concentration of 84.7%, nutritionally equal to the standard AIN-93G diet. Another blank control group of male rats were treated with commercial AIN-93G diet. No significant differences in body weight, hematology and serum chemistry results were observed between rats fed with the diets containing transgenic BT799, Zhen58 and the control in this 13-week feeding study. Results of serum hormone levels, sperm parameters and relative organ/body weights indicated no treatment-related side effects on the reproductive system of male rats. In addition, no diet-related changes were found in necropsy and histopathology examinations. Based on results of the current study, we did not find any differences in the parameters tested in our study of the reproductive system of male rats between BT799 and Zhen58 or the control. PMID:26633453

  16. Developing Strong Board Relationships during the First 90 Days: Strategies for Aspiring Superintendents

    ERIC Educational Resources Information Center

    Valdes, Rene Martin

    2012-01-01

    Federal, state, and local accountability mandates (i.e., No Child Left Behind Act of 2001) and declining fiscal resources have put increasing pressure on school boards to find the "right" superintendent that can lead their district through this tumultuous period in public education. With over 50% of the current superintendents planning…

  17. Visual-motor response of crewmen during a simulated 90-day space mission as measured by the critical task battery

    NASA Technical Reports Server (NTRS)

    Allen, R. W.; Jex, H. R.

    1973-01-01

    In order to test various components of a regenerative life support system and to obtain data on the physiological and psychological effects of long duration exposure to confinement in a space station atmosphere, four carefully screened young men were sealed in a space station simulator for 90 days and administered a tracking test battery. The battery included a clinical test (Critical Instability Task) designed to measure a subject's dynamic time delay, and a more conventional steady tracking task, during which dynamic response (describing functions) and performance measures were obtained. Good correlation was noted between the clinical critical instability scores and more detailed tracking parameters such as dynamic time delay and gain-crossover frequency. The levels of each parameter span the range observed with professional pilots and astronaut candidates tested previously. The chamber environment caused no significant decrement on the average crewman's dynamic response behavior, and the subjects continued to improve slightly in their tracking skills during the 90-day confinement period.

  18. Chronic kidney disease is associated with a higher 90-day mortality than other chronic medical conditions in patients with sepsis

    PubMed Central

    Mansur, Ashham; Mulwande, Evelyn; Steinau, Maximilian; Bergmann, Ingo; Frederik Popov, Aron; Ghadimi, Michael; Beissbarth, Tim; Bauer, Martin; Hinz, José

    2015-01-01

    According to previous studies, the clinical course of sepsis could be affected by preexisting medical conditions, which are very common among patients with sepsis. This observational study aimed at investigating whether common chronic medical conditions affect the 90-day mortality risk in adult Caucasian patients with sepsis. A total of 482 patients with sepsis were enrolled in this study. The ninety-day mortality was the primary outcome; organ failure was the secondary outcome. Sepsis-related organ failure assessment (SOFA) scores and the requirements for organ support were evaluated to assess organ failure. A multivariate Cox regression model for the association between the 90-day mortality risk and chronic preexisting medical conditions adjusted for all relevant confounders and mortality predictors revealed the highest hazard ratio for patients with chronic kidney disease (CKD) (hazard ratio, 2.25; 95% CI, 1.46-3.46; p = 0.0002). Patients with CKD had higher SOFA scores than patients without CKD (8.9 ± 4.0 and 6.5 ± 3.4, respectively; p < 0.0001). Additionally, an analysis of organ-specific SOFA scores revealed higher scores in three organ systems (kidney, cardiovascular and coagulation). Patients with CKD have the highest 90-day mortality risk compared with patients without CKD or with other chronic medical conditions. PMID:25995131

  19. Inhalation toxicity study of disk-shaped potassium octatitanate particles (terracess TF) in rats following 90 days of aerosol exposure.

    PubMed

    Sakai, Seiya; Inada, Kousuke; Tanaka, Akira K; Kelly, David P; Sykes, Greg P; Lee, K P

    2010-01-01

    Since fibrous particles such as asbestos and some man-made fibers (MMF) have been known to produce carcinogenic or fibrogenic effects, disk-shaped potassium octatitanate (POT) particles (trade name: Terracess TF) were manufactured as nonfibrous particles. A 90-day inhalation toxicity study of Terracess TF was performed to evaluate comparative inhalation toxicity of the disk shape with a fibrous shape that was previously evaluated. Four groups of 20 male and 15 female rats each were exposed to Terracess TF aerosols at concentrations of 0, 2, 10, or 50 mg/m(3) for 90 days. Ten male and 10 female rats per group were sacrificed at 90 days of exposure. After 90 days of exposure, 5 male rats per group were sacrificed at 3 wk of recovery period and 4-5 male rats per group or 5 female rats per group were sacrificed at 15 wk of recovery for lung clearance and histopathology. The mass median aerodynamic equivalent diameter (MMAED) of the aerosols of test materials ranged from 2.5 to 2.9 microm. There were no test-substance-related adverse effects on clinical observations. At the end of the 90-day exposure, a slight increase in lung-to-body weight ratios was observed at 50 mg/m(3) in male but not in female rats. However, lung weights were within normal limits after 3- or 15-wk recovery periods. Microscopically, inhaled Terracess TF particles were mostly phagocytized by free alveolar macrophages (AMs) in the alveolar airspaces and alveolar walls maintained normal structure at 2 and 10 mg/m(3). At 50 mg/m(3), some alveoli were distended and filled with aggregates of particle-laden AMs. The alveolar walls showed slight type II pneumocyte hyperplasia, but neither proliferative inflammation nor alveolar fibrosis was present at 50 mg/m(3). The clearance half-times for Terracess TF were estimated to be in the order of 6 to 9 mo for the 50-mg/m(3) group and 2 to 3 mo for the 10- and 2-mg/m(3) groups. The lung responses and lung clearance rate were comparable to those of "nuisance

  20. First Report of 90-Day Support of Two Calves with a Continuous-Flow Total Artificial Heart

    PubMed Central

    Karimov, Jamshid H.; Moazami, Nader; Kobayashi, Mariko; Sale, Shiva; Such, Kimberly; Byram, Nicole; Sunagawa, Gengo; Horvath, David; Gao, Shengqiang; Kuban, Barry; Golding, Leonard A.; Fukamachi, Kiyotaka

    2015-01-01

    Objective The Cleveland Clinic continuous-flow total artificial heart (CFTAH) is a compact, single-piece, valveless, pulsatile pump providing self-regulated hemodynamic output to left/right circulation. We evaluated chronic in vivo pump performance, physiologic and hemodynamic parameters, and biocompatibility of the CFTAH in a well-established calf model. Methods CFTAH pumps have been implanted in 17 calves total. Hemodynamics, pump performance, and device-related adverse events were evaluated during studies and at necropsy. Results In vivo experiments demonstrated good hemodynamic performance (pump flow, 7.3 ± 0.7 L/min; left atrial pressure [LAP], 16 ± 3 mm Hg; right atrial pressure [RAP], 17 ± 3 mm Hg; RAP-LAP difference, 1 ± 2 mm Hg; mean arterial pressure, 103 ± 7 mm Hg; arterial pulse pressure, 30 ± 11 mm Hg; pulmonary arterial pressure, 34 ± 5 mm Hg). The CFTAH has operated within design specifications and never failed. With ever-improving pump design, the implants have shown no chronic hemolysis. Three recent animals with the CFTAH recovered well, with no postoperative anticoagulation, during planned in vivo durations of 30, 90, and 90 days (last two were intended to be 90-day studies). All these longest-surviving cases showed good biocompatibility, with no thromboembolism in organs. Conclusions The current CFTAH has demonstrated reliable self-regulation of hemodynamic output and acceptable biocompatibility without anticoagulation throughout 90 days of chronic implantation in calves. Meeting these milestones is in accord with our strategy to achieve transfer of this unique technology to surgical practice, thus filling the urgent need for cardiac replacement devices as destination therapy. PMID:26173607

  1. Toxicological assessment of a prototype e-cigaret device and three flavor formulations: a 90-day inhalation study in rats.

    PubMed

    Werley, Michael S; Kirkpatrick, Dan J; Oldham, Michael J; Jerome, Ann M; Langston, Timothy B; Lilly, Patrick D; Smith, Donna C; Mckinney, Willie J

    2016-01-01

    A prototype electronic cigaret device and three formulations were evaluated in a 90-day rat inhalation study followed by a 42-day recovery period. Animals were randomly assigned to groups for exposure to low-, mid- and high-dose levels of aerosols composed of vehicle (glycerin and propylene glycol mixture); vehicle and 2.0% nicotine; or vehicle, 2.0% nicotine and flavor mixture. Daily targeted aerosol total particulate matter (TPM) doses of 3.2, 9.6 and 32.0 mg/kg/day were achieved by exposure to 1 mg/L aerosol for 16, 48 and 160 min, respectively. Pre-study evaluations included indirect ophthalmoscopy, virology and bacteriological screening. Body weights, clinical observations and food consumption were monitored weekly. Plasma nicotine and cotinine and carboxyhemoglobin levels were measured at days 28 and 90. After days 28, 56 and 90, lung function measurements were obtained. Biological endpoints after 90-day exposure and 42-day recovery period included clinical pathology, urinalysis, bronchoalveolar fluid (BALF) analysis, necropsy and histopathology. Treatment-related effects following 90 days of exposure included changes in body weight, food consumption and respiratory rate. Dose-related decreases in thymus and spleen weights, and increased BALF lactate dehydrogenase, total protein, alveolar macrophages, neutrophils and lung weights were observed. Histopathology evaluations revealed sporadic increases in nasal section 1-4 epithelial hyperplasia and vacuolization. Following the recovery period, effects in the nose and BALF were persistent while other effects were resolved. The no observed effect level based upon body weight decreases is considered to be the mid-dose level for each formulation, equivalent to a daily TPM exposure dose of approximately 9.6 mg/kg/day. PMID:26787428

  2. Toxicological assessment of a prototype e-cigaret device and three flavor formulations: a 90-day inhalation study in rats

    PubMed Central

    Werley, Michael S.; Kirkpatrick, Dan J.; Oldham, Michael J.; Jerome, Ann M.; Langston, Timothy B.; Lilly, Patrick D.; Smith, Donna C.; Mckinney, Willie J.

    2016-01-01

    Abstract A prototype electronic cigaret device and three formulations were evaluated in a 90-day rat inhalation study followed by a 42-day recovery period. Animals were randomly assigned to groups for exposure to low-, mid- and high-dose levels of aerosols composed of vehicle (glycerin and propylene glycol mixture); vehicle and 2.0% nicotine; or vehicle, 2.0% nicotine and flavor mixture. Daily targeted aerosol total particulate matter (TPM) doses of 3.2, 9.6 and 32.0 mg/kg/day were achieved by exposure to 1 mg/L aerosol for 16, 48 and 160 min, respectively. Pre-study evaluations included indirect ophthalmoscopy, virology and bacteriological screening. Body weights, clinical observations and food consumption were monitored weekly. Plasma nicotine and cotinine and carboxyhemoglobin levels were measured at days 28 and 90. After days 28, 56 and 90, lung function measurements were obtained. Biological endpoints after 90-day exposure and 42-day recovery period included clinical pathology, urinalysis, bronchoalveolar fluid (BALF) analysis, necropsy and histopathology. Treatment-related effects following 90 days of exposure included changes in body weight, food consumption and respiratory rate. Dose-related decreases in thymus and spleen weights, and increased BALF lactate dehydrogenase, total protein, alveolar macrophages, neutrophils and lung weights were observed. Histopathology evaluations revealed sporadic increases in nasal section 1–4 epithelial hyperplasia and vacuolization. Following the recovery period, effects in the nose and BALF were persistent while other effects were resolved. The no observed effect level based upon body weight decreases is considered to be the mid-dose level for each formulation, equivalent to a daily TPM exposure dose of approximately 9.6 mg/kg/day. PMID:26787428

  3. Safety assessment of essential oil from Minthostachys verticillata (Griseb.) Epling (peperina): 90-days oral subchronic toxicity study in rats.

    PubMed

    Escobar, Franco Matías; Sabini, María Carola; Cariddi, Laura Noelia; Sabini, Liliana Inés; Mañas, Fernando; Cristofolini, Andrea; Bagnis, Guillermo; Gallucci, Mauro Nicolas; Cavaglieri, Lilia Renée

    2015-02-01

    Minthostachys verticillata (Lamiaceae), popularly known as peperina is largely used in popular medicine for its digestive, carminative, antispasmodic and antirheumatic properties. There are no reports of repeated exposure toxicity to guarantee their safety. The present study investigated the chemical composition, analyzed by GC-FID, and the 90-day toxicity and genotoxicity effect of M. verticillata essential oil (Mv-EO), using Wistar rats as test animals. The rats were divided into four groups (5 rats/sex/group) and Mv-EO was administered on diet at doses of 0, 1, 4 and 7 g/kg feed. The main components of Mv-EO were pulegone (64.65%) and menthone (23.92%). There was no mortality, adverse effects on general conditions or changes in body weight, food consumption and feed conversion efficiency throughout the study in male and female rats. Subchronic administration of Mv-EO did not alter the weights, morphological and histopathological analyses of liver, kidney and intestine. Genotoxicity was tested by micronucleus and comet assays. Mv-EO up to a concentration of 7 g/kg feed for 90 days did not exert a cyto-genotoxic effect on the bone marrow and cells blood of Wistar rats. These results suggest that Mv-EO appears to be safe and could be devoid of any toxic risk.

  4. Effects of 90-day feeding of transgenic Bt rice TT51 on the reproductive system in male rats.

    PubMed

    Wang, Er Hui; Yu, Zhou; Hu, Jing; Xu, Hai Bin

    2013-12-01

    Rice is a staple food crop; however, the threat of pests leads to a serious decline in its output and quality. The CryAb/CryAc gene, encodes a synthetic fusion Bacillus thuringiensis (Bt) crystal protein, was introduced into rice MingHui63 to produce insect-resistant rice TT51. This study was undertaken to investigate potential unintended effects of TT51 on the reproductive system in male rats. Male rats were treated with diets containing 60% of either TT51 or MingHui63 by weight, nutritionally balanced to an AIN93G diet, for 90days. An additional negative control group of rats were fed with a rice-based AIN93G diet. Body weights, food intake, hematology, serum chemistry, serum hormone levels, sperm parameters and relative organ/body weights were measured, and gross as well as microscopic pathology were examined. No diet-related significant differences in the values of response variables were observed between rats that were fed with diet containing transgenic TT51, MingHui63 and the control in this 90-day feeding study. In addition, necropsy and histopathology examination indicated no treatment-related changes. The results from the present study indicated that TT51 does not appear to exert any effect on the reproductive system in male rats compared with MingHui63 or the control.

  5. The development and succession of microbial communities in 90-day Bioregenerative Life Support Experiment in the Lunar Palace 1

    NASA Astrophysics Data System (ADS)

    Sun, Yi; Liu, Hong; Fu, Yuming; Liu, Bojie; Su, Qiang; Xie, Beizhen; Qin, Youcai; Dong, Chen; Liu, Guanghui

    Lunar Palace 1, as an integrative experiment facility for permanent astrobase life-support artificial closed ecosystem, is an artificial ecosystem which consists of plant cultivation, animal breeding and waste treatment units. It has been used to carry out a 90-day bioregenerative life support experiment with three crew members. Apparently, it’s hard to prevent the growth of microorganisms in such closed ecosystem for their strong adaptive capacity. Original microorganisms in the cabin, microbes in the course of loads delivery and the autologous microorganism by crew members and animals themselves are all the main source of the interior microorganisms, which may grow and regenerate in air, water and plants. Therefore, if these microorganisms could not be effectively monitored and controlled, it may cause microbial contamination and even lead to the unsteadiness of the whole closed ecosystem. In this study, the development and succession of the microbial communities of air, water system, plant system, and key facilities surfaces in Lunar Palace 1 were continuously monitored and analyzed by using plate counting method and molecular biological method during the 90-day experiment. The results were quite useful for the controlling of internal microorganisms and the safe operation of the whole system, and could also reveal the succession rules of microorganisms in an artificial closed ecosystem.

  6. 90-Day Cycle: Exploration of Math Intensives as a Strategy to Move More Community College Students out of Developmental Math Courses

    ERIC Educational Resources Information Center

    Sherer, Jennifer Zoltners; Grunow, Alicia

    2010-01-01

    The authors prepared this report after exploring programs using a 90-day cycle process borrowed from the Institute for Healthcare Improvement (IHI). The IHI 90-day cycle scans activity in the field as a "quick way to research innovative ideas and assess their potential for advancing quality improvement". The goal was to "get under the hood" of…

  7. Vertical jump performance after 90 days bed rest with and without flywheel resistive exercise, including a 180 days follow-up.

    PubMed

    Rittweger, Jörn; Felsenberg, Dieter; Maganaris, Constantinos; Ferretti, José Luis

    2007-07-01

    Muscle atrophy and neuromuscular de-conditioning occur in response to space flight and bed-rest. In this study, we investigated the efficacy of flywheel training to conserve jumping power and height during 90 days bed rest. Twenty-four young healthy men underwent strict bed-rest (-6 degrees head down tilt) for 90 days. Eight participants were assigned to a flywheel group (FW) and 16 to a control group (Ctrl). The ground reaction force was measured during vertical jump tests twice during baseline data collection, and on day 4, 7, 14, 90 and 180 of recovery. In half of the participants, jump tests were also performed within minutes after re-ambulation and on four more occasions during the first 2 days of recovery. Jump height was reduced from 40.6 cm (SD 6.1 cm) during the first baseline measurement to 27.6 cm (SD 5.6 cm) on day 4 of recovery in Ctrl, but only from 38.6 cm (SD 3.9 cm) to 34.4 cm (SD 6.5 cm) in FW (P < 0.001). At the same time, peak power was reduced from 47.4 W/kg (SD 8.0 W/kg) to 34.5 W/kg in Ctrl, but only from 46.2 W/kg (6.0 W/kg) to 42.2 W/kg SD 4.6 W/kg) in FW (P < 0.001). Jump height and peak power were completely recovered after 163 and 140 days in Ctrl, respectively, and after 72 and 18 days in FW (regression analysis). In conclusion, flywheel exercise could effectively offset neuromuscular de-conditioning during bed-rest, and led to full recovery at an earlier stage. These findings nourish the hope that adequate training paradigms can fully sustain neuromuscular function under microgravity conditions. PMID:17406887

  8. Dietary and Food Processing for a 90-day Bioregenerative Life Support Experiment in the Lunar Palace 1

    NASA Astrophysics Data System (ADS)

    Zhao, Zhiruo; Fu, Yuming; Dong, Chen; Liu, Guanghui

    A 4-day cycle dietary menu was developed to meet the requirements of balanced diet of the crew within the 90-day closed experiment of bioregenerative life support in the Lunar Palace 1. The menu consisted of items prepared from crops and insect grown inside the system, as well as prestored food. Dairy recipe was composed of breads, vegetables, meats and soups, which provided about 2900 kcal per crew member per day. During food processing, to maximize nutrient recovery and minimize waste production, the whole wheat grains and chufa nuts were milled. Further, the carrot leaves and yellow mealworms were used as salad materials and bread ingredients, respectively. The sensory acceptability of the dishes in the menu was evaluated by flavor, texture, and appearance. Our results show that all dishes in the 4-day cycle menu were highly acceptable, which satisfies nutritional requirement of the crew members in the closed habitation.

  9. Toxicity of 100 nm zinc oxide nanoparticles: a report of 90-day repeated oral administration in Sprague Dawley rats

    PubMed Central

    Kim, Yu-Ri; Park, Jong-Il; Lee, Eun Jeong; Park, Sung Ha; Seong, Nak-won; Kim, Jun-Ho; Kim, Geon-Yong; Meang, Eun-Ho; Hong, Jeong-Sup; Kim, Su-Hyon; Koh, Sang-Bum; Kim, Min-Seok; Kim, Cheol-Su; Kim, Soo-Ki; Son, Sang Wook; Seo, Young Rok; Kang, Boo Hyon; Han, Beom Seok; An, Seong Soo A; Yun, Hyo-In; Kim, Meyoung-Kon

    2014-01-01

    Nanoparticles (NPs) are used commercially in health and fitness fields, but information about the toxicity and mechanisms underlying the toxic effects of NPs is still very limited. The aim of this study is to investigate the toxic effect(s) of 100 nm negatively (ZnOAE100[−]) or positively (ZnOAE100[+]) charged zinc oxide (ZnO) NPs administered by gavage in Sprague Dawley rats, to establish a no observed adverse effect level, and to identify target organ(s). After verification of the primary particle size, morphology, hydrodynamic size, and zeta potential of each test article, we performed a 90-day study according to Organisation for Economic Co-operation and Development test guideline 408. For the 90-day study, the high dose was set at 500 mg/kg and the middle and low doses were set at 125 mg/kg and 31.25 mg/kg, respectively. Both ZnO NPs had significant changes in hematological and blood biochemical analysis, which could correlate with anemia-related parameters, in the 500 mg/kg groups of both sexes. Histopathological examination showed significant adverse effects (by both test articles) in the stomach, pancreas, eye, and prostate gland tissues, but the particle charge did not affect the tendency or the degree of the lesions. We speculate that this inflammatory damage might result from continuous irritation caused by both test articles. Therefore, the target organs for both ZnOAE100(−) and ZnOAE100(+) are considered to be the stomach, pancreas, eye, and prostate gland. Also, the no observed adverse effect level for both test articles was identified as 31.25 mg/kg for both sexes, because the adverse effects were observed at all doses greater than 125 mg/kg. PMID:25565830

  10. A 90-day safety study in Wistar rats fed genetically modified rice expressing snowdrop lectin Galanthus nivalis (GNA).

    PubMed

    Poulsen, Morten; Kroghsbo, Stine; Schrøder, Malene; Wilcks, Andrea; Jacobsen, Helene; Miller, Andreas; Frenzel, Thomas; Danier, Jürgen; Rychlik, Michael; Shu, Qingyao; Emami, Kaveh; Sudhakar, Duraialagraja; Gatehouse, Angharad; Engel, Karl-Heinz; Knudsen, Ib

    2007-03-01

    Genetically modified plants expressing insecticidal traits offer a new strategy for crop protection, but at the same time present a challenge in terms of food safety assessment. The present 90-day feeding study was designed to assess the safety of a rice variety expressing the snowdrop Galanthus nivalis lectin (GNA lectin), and forms part of a EU-funded project where the objective has been to develop and validate sensitive and specific methods to assess the safety of genetically modified foods. Male and female Wistar rats were given a purified diet containing either 60% genetically modified or parental rice for 90 days. This corresponds to a mean daily GNA lectin intake of approximately 58 and 67mg/kg body weight for males and females, respectively. Prior to the animal study comprehensive analytical characterization of both rice materials was performed. The chemical analyses showed a number of statistically significant differences, with the majority being within the ranges reported in the literature. In the animal study a range of clinical, biological, immunological, microbiological and pathological parameters were examined. A number of significant differences were seen between groups fed the two diets, but none of them were considered to be adverse. In conclusion, the design of the present animal study did not enable us to conclude on the safety of the GM food. Additional group(s) where the expressed gene products have been spiked to the diet should be included in order to be able to distinguish whether the observed effects were due to the GNA lectin per se or to secondary changes in the GM rice.

  11. Toxicity of 100 nm zinc oxide nanoparticles: a report of 90-day repeated oral administration in Sprague Dawley rats.

    PubMed

    Kim, Yu-Ri; Park, Jong-Il; Lee, Eun Jeong; Park, Sung Ha; Seong, Nak-won; Kim, Jun-Ho; Kim, Geon-Yong; Meang, Eun-Ho; Hong, Jeong-Sup; Kim, Su-Hyon; Koh, Sang-Bum; Kim, Min-Seok; Kim, Cheol-Su; Kim, Soo-Ki; Son, Sang Wook; Seo, Young Rok; Kang, Boo Hyon; Han, Beom Seok; An, Seong Soo A; Yun, Hyo-In; Kim, Meyoung-Kon

    2014-01-01

    Nanoparticles (NPs) are used commercially in health and fitness fields, but information about the toxicity and mechanisms underlying the toxic effects of NPs is still very limited. The aim of this study is to investigate the toxic effect(s) of 100 nm negatively (ZnO(AE100[-])) or positively (ZnO(AE100[+])) charged zinc oxide (ZnO) NPs administered by gavage in Sprague Dawley rats, to establish a no observed adverse effect level, and to identify target organ(s). After verification of the primary particle size, morphology, hydrodynamic size, and zeta potential of each test article, we performed a 90-day study according to Organisation for Economic Co-operation and Development test guideline 408. For the 90-day study, the high dose was set at 500 mg/kg and the middle and low doses were set at 125 mg/kg and 31.25 mg/kg, respectively. Both ZnO NPs had significant changes in hematological and blood biochemical analysis, which could correlate with anemia-related parameters, in the 500 mg/kg groups of both sexes. Histopathological examination showed significant adverse effects (by both test articles) in the stomach, pancreas, eye, and prostate gland tissues, but the particle charge did not affect the tendency or the degree of the lesions. We speculate that this inflammatory damage might result from continuous irritation caused by both test articles. Therefore, the target organs for both ZnO(AE100(-)) and ZnO(AE100(+)) are considered to be the stomach, pancreas, eye, and prostate gland. Also, the no observed adverse effect level for both test articles was identified as 31.25 mg/kg for both sexes, because the adverse effects were observed at all doses greater than 125 mg/kg. PMID:25565830

  12. Two-hour methyl isocyanate inhalation and 90-day recovery study in B6C3F1 mice

    SciTech Connect

    Boorman, G.A.; Uraih, L.C.; Gupta, B.N.; Bucher, J.R.

    1987-06-01

    B6C3F1 mice were exposed by inhalation to 0, 3, 10, and 30 ppm methyl isocyanate for 2 hr followed by a 90-day recovery period. Sixteen of eight (20%) male mice in the 30 ppm group died following exposure. There were no other unscheduled deaths in the mice. Five mice/sex/group were examined at 2 hr or at 1, 3, 7, 14, 28, 49, or 91 days following exposure. Chemical-related changes were restricted to the respiratory system. At 30 ppm there were extensive necrosis and erosion of the respiratory and olfactory epithelium in the nasal cavity. Severe necrosis and epithelial erosion were also found in the trachea and main bronchi. Regeneration of the mucosal epithelium occurred rapidly in the nasal cavity and airways. In the turbinates, mild incomplete olfactory epithelial regeneration persisted to day 91 in the male mice. Intraluminal fibrotic projections covered by respiratory epithelium and bronchial fibrosis were found in the major airways of the 30 ppm male and female mice by day 7. The intraluminal fibrosis persisted to day 91. In males with severe bronchial fibrosis, chronic alveolitis and atelectasis were found. In mice exposed to 3 or 10 ppm, persistent pulmonary changes were not found. These studies indicate that methyl isocyanate inhalation at or near lethal concentrations can cause persistent fibrosis of the major bronchi in mice.

  13. Anatomical sector analysis of load-bearing tibial bone structure during 90-day bed rest and 1-year recovery.

    PubMed

    Cervinka, Tomas; Rittweger, Jörn; Hyttinen, Jari; Felsenberg, Dieter; Sievänen, Harri

    2011-07-01

    The aim of this study was to investigate whether the bone response to long bed rest-related immobility and during subsequent recovery differed at anatomically different sectors of tibial epiphysis and diaphysis. For this study, peripheral quantitative tomographic (pQCT) scans obtained from a previous 90-day 'Long Term Bed Rest' intervention were preprocessed with a new method based on statistical approach and re-analysed sector-wise. The pQCT was performed on 25 young healthy males twice before the bed rest, after the bed rest and after 1-year follow-up. All men underwent a strict bed rest intervention, and in addition, seven of them received pamidronate treatment and nine did flywheel exercises as countermeasures against disuse-related bone loss. Clearly, 3-9% sector-specific losses in trabecular density were observed at the tibial epiphysis on average. Similarly, cortical density decreased in a sector-specific way being the largest at the anterior sector of tibial diaphysis. During recovery, the bed rest-induced bone losses were practically restored and no consistent sector-specific modulation was observed in any subgroup. It is concluded that the sector-specific analysis of bone cross-sections has potential to reveal skeletal responses to various interventions that cannot be inferred from the average analysis of the whole bone cross-section. This approach is considered also useful for evaluating the bone responses from the biomechanical point of view. PMID:21672131

  14. A 90-day subchronic feeding study of genetically modified rice expressing Cry1Ab protein in Sprague-Dawley rats.

    PubMed

    Song, Huan; He, Xiaoyun; Zou, Shiying; Zhang, Teng; Luo, Yunbo; Huang, Kunlun; Zhu, Zhen; Xu, Wentao

    2015-04-01

    Bacillus thuringiensis (Bt) transgenic rice line (mfb-MH86) expressing a synthetic cry1Ab gene can be protected against feeding damage from Lepidopteran insects, including Sesamia inferens, Chilo suppressalis, Tryporyza incertulas and Cnaphalocrocis medinalis. Rice flour from mfb-MH86 and its near-isogenic control MH86 was separately formulated into rodent diets at concentrations of 17.5, 35 and 70 % (w/w) for a 90-day feeding test with rats, and all of the diets were nutritionally balanced. In this study, the responses of rats fed diets containing mfb-MH86 were compared to those of rats fed flour from MH86. Overall health, body weight and food consumption were comparable between groups fed diets containing mfb-MH86 and MH86. Blood samples were collected prior to sacrifice and a few significant differences (p < 0.05) were observed in haematological and biochemical parameters between rats fed genetically modified (GM) and non-GM diets. However, the values of these parameters were within the normal ranges of values for rats of this age and sex, thus not considered treatment related. In addition, upon sacrifice a large number of organs were weighed, macroscopic and histopathological examinations were performed with only minor changes to report. In conclusion, these results demonstrated that no toxic effect was observed in the conditions of the experiment, based on the different parameters assessed. GM rice mfb-MH86 is as safe and nutritious as non-GM rice.

  15. Results of a 90-day safety assurance study with rats fed grain from corn rootworm-protected corn.

    PubMed

    Hammond, B; Lemen, J; Dudek, R; Ward, D; Jiang, C; Nemeth, M; Burns, J

    2006-02-01

    The results of a 90-day rat feeding study with YieldGard (YieldGard Rootworm Corn is a registered trademark of Monsanto Technology, LLC.) Rootworm corn (MON 863) grain that is protected against feeding damage caused by corn rootworm larvae are presented. Corn rootworm-protection was accomplished through the introduction of a cry3Bb1 coding sequence into the corn genome for in planta production of a modified Cry3Bb1 protein from Bacillus thuringiensis. Grain from MON 863 and its near isogenic control were separately formulated into rodent diets at levels of 11% and 33% (w/w) by Purina Mills, Inc. Additionally, six groups of rats were fed diets containing grain from different conventional (non-biotechnology-derived) reference varieties. The responses of rats fed diets containing MON 863 were compared to those of rats fed grain from conventional corn varieties. All diets were nutritionally balanced and conformed to Purina Mills, Inc. specifications for Certified LabDiet 5002. There were a total of 400 rats in the study divided into 10 groups of 20 rats/sex/group. Overall health, body weight gain, food consumption, clinical pathology parameters (hematology, blood chemistry, urinalysis), organ weights, gross and microscopic appearance of tissues were comparable between groups fed diets containing MON 863 and conventional corn varieties. This study complements extensive agronomic, compositional and farm animal feeding studies with MON 863 grain, confirming that it is as safe and nutritious as existing conventional corn varieties.

  16. A 90-day toxicology study of high-amylose transgenic rice grain in Sprague-Dawley rats.

    PubMed

    Zhou, Xing Hua; Dong, Ying; Xiao, Xiang; Wang, Yun; Xu, Yong; Xu, Bin; Shi, Wei Dong; Zhang, Yi; Zhu, Li Jia; Liu, Qiao Quan

    2011-12-01

    A transgenic rice line (TRS) with high amylose level has been developed by antisense RNA inhibition of starch branching enzymes. Compositional analysis of TRS demonstrated that the content of resistant starch (RS) was significantly higher compared to conventional non-transgenic rice. High level of RS is an important raw material in food industry and has various physiological effects for human health. In order to provide the reliable theory basis for field release of TRS rice, we evaluated the potential health effects of long-term consumption of the TRS. The 90-day toxicology feeding experiment was conducted in Sprague-Dawley rats fed with diets containing 70% of either TRS rice flour, its near-isogenic rice flour or the control diet. The clinical performance variables (body weight, body weight gain and food consumption) were measured and pathological responses (hematological parameters and serum chemistry at the midterm and the completion of the experiment, urinalysis profile and serum sex hormone response at the completion of the experiment) were performed. Besides, clinical signs, relative organ weights and microscopic observations were also compared between TRS group and its near-isogenic rice group. The combined data indicates that high-amylose TRS grain is as safe as the conventional non-transgenic rice for rat consumption.

  17. A 90-day toxicology study of transgenic lysine-rich maize grain (Y642) in Sprague-Dawley rats.

    PubMed

    He, Xiao Yun; Tang, Mao Zhi; Luo, Yun Bo; Li, Xin; Cao, Si Shuo; Yu, Jing Juan; Delaney, Bryan; Huang, Kun Lun

    2009-02-01

    The gene for a lysine-rich protein (sb401) obtained from potatoes (Solanum berthaultii) was inserted into maize seed to produce Y642 transgenic maize. Compositional analysis of Y642 grain demonstrated that the concentrations of lysine and total protein were higher than those observed in maize grain from a near-isogenic non-genetically modified (non-GM) commercially available control quality protein maize (Nongda 108). The safety of Y642 maize grain was assessed by comparison of toxicology response variables in Sprague-Dawley (SD) rats consuming diets containing Y642 maize grain with those containing Nongda 108 maize grain. Maize grains from Y642 or Nongda 108 were incorporated into rodent diets at low (30%) or high concentrations (76%) and administered to SD rats (n=10/sex/group) for 90 days. An additional group of negative control group of rats (n=10/sex/group) were fed AIN93G diets. No adverse diet-related differences in body weights, feed consumption/utilization, clinical chemistry, hematology, absolute and relative organ weights were observed. Further, no differences in gross or microscopic pathology were observed between rats consuming diets with Y642 maize grain compared with rats consuming diets containing Nongda 108 maize grain. These results demonstrated that Y642 lysine-rich maize is as safe and nutritious as conventional quality protein maize.

  18. Results of a 90-day safety assurance study with rats fed grain from corn borer-protected corn.

    PubMed

    Hammond, B G; Dudek, R; Lemen, J K; Nemeth, M A

    2006-07-01

    The results of a 90-day rat feeding study with grain from MON 810 corn (YieldGard Cornborer -- YieldGard Cornborer is a registered trademark of Monsanto Technology, LLC) that is protected against feeding damage from corn and stalk boring lepidopteran insects are presented. Corn borer protection was accomplished through the introduction of cry1Ab coding sequences into the corn genome for in planta production of a bioactive form of Cry1Ab protein. Grain from MON 810 and its near-isogenic control was separately formulated into rodent diets at levels of 11% and 33% (w/w) by Purina Mills, Inc. (PMI). All diets were nutritionally balanced and conformed to PMI specifications for Certified LabDiet (PMI Certified LabDiet 5002 is a registered trademark of Purina Mills, Inc.) 5002. There were a total of 400 rats in the study divided into 10 groups of 20 rats/sex/group. The responses of rats fed diets containing MON 810 were compared to those of rats fed grain from conventional corn varieties. Overall health, body weight, food consumption, clinical pathology parameters (hematology, blood chemistry, urinalysis), organ weights, and gross and microscopic appearance of tissues were comparable between groups fed diets containing MON 810 and conventional corn varieties. This study complements extensive agronomic, compositional and farm animal feeding studies with MON 810 grain, confirming that it is as safe and nutritious as grain from existing commercial corn varieties.

  19. Fluid overload is associated with an increased risk for 90-day mortality in critically ill patients with renal replacement therapy: data from the prospective FINNAKI study

    PubMed Central

    2012-01-01

    Introduction Positive fluid balance has been associated with an increased risk for mortality in critically ill patients with acute kidney injury with or without renal replacement therapy (RRT). Data on fluid accumulation prior to RRT initiation and mortality are limited. We aimed to study the association between fluid accumulation at RRT initiation and 90-day mortality. Methods We conducted a prospective, multicenter, observational cohort study in 17 Finnish intensive care units (ICUs) during a five-month period. We collected data on patient characteristics, RRT timing, and parameters at RRT initiation. We studied the association of parameters at RRT initiation, including fluid overload (defined as cumulative fluid accumulation > 10% of baseline weight) with 90-day mortality. Results We included 296 RRT-treated critically ill patients. Of 283 patients with complete data on fluid balance, 76 (26.9%) patients had fluid overload. The median (interquartile range) time from ICU admission to RRT initiation was 14 (3.3 to 41.5) hours. The 90-day mortality rate of the whole cohort was 116 of 296 (39.2%; 95% confidence interval 38.6 to 39.8%). The crude 90-day mortality of patients with or without fluid overload was 45 of 76 (59.2%) vs. 65 of 207 (31.4%), P < 0.001. In logistic regression, fluid overload was associated with an increased risk for 90-day mortality (odds ratio 2.6) after adjusting for disease severity, time of RRT initiation, initial RRT modality, and sepsis. Of the 168 survivors with data on RRT use at 90 days, 34 (18.9%, 95% CI 13.2 to 24.6%) were still dependent on RRT. Conclusions Patients with fluid overload at RRT initiation had twice as high crude 90-day mortality compared to those without. Fluid overload was associated with increased risk for 90-day mortality even after adjustments. PMID:23075459

  20. A 90-day study of sub-chronic oral toxicity of 20 nm positively charged zinc oxide nanoparticles in Sprague Dawley rats

    PubMed Central

    Park, Hark-Soo; Kim, Seon-Ju; Lee, Taek-Jin; Kim, Geon-Yong; Meang, EunHo; Hong, Jeong-Sup; Kim, Su-Hyon; Koh, Sang-Bum; Hong, Seung-Guk; Sun, Yle-Shik; Kang, Jin Seok; Kim, Yu-Ri; Kim, Meyoung-Kon; Jeong, Jayoung; Lee, Jong-Kwon; Son, Woo-Chan; Park, Jae-Hak

    2014-01-01

    Purpose The study reported here was conducted to determine the systemic oral toxicity and to find the no-observed-adverse-effect level of 20 nm positively charged zinc oxide (ZnOSM20(+)) nanoparticles in Sprague Dawley rats for 90 days. Methods For the 90-day toxicity study, the high dose was set as 500 mg per kg of body weight (mg/kg) and the middle and low dose were set to 250 mg/kg and 125 mg/kg, respectively. The rats were held for a 14-day recovery period after the last administration, to observe for the persistence or reduction of any toxic effects. A distributional study was also carried out for the systemic distribution of ZnOSM20(+) NPs. Results No rats died during the test period. There were no significant clinical changes due to the test article during the experimental period in functional assessment, body weight, food and water consumption, ophthalmological testing, urine analysis, necropsy findings, or organ weights, but salivation was observed immediately after administration in both sexes. The total red blood cell count was increased, and hematocrit, albumin, mean cell volume, mean cell hemoglobin, and mean cell hemoglobin concentration were decreased significantly compared with control in both 500 mg/kg groups. Total protein and albumin levels were decreased significantly in both sexes in the 250 and 500 mg/kg groups. Histopathological studies revealed acinar cell apoptosis in the pancreas, inflammation and edema in stomach mucosa, and retinal atrophy of the eye in the 500 mg/kg group. Conclusion There were significant parameter changes in terms of anemia in the hematological and blood chemical analyses in the 250 and 500 mg/kg groups. The significant toxic change was observed to be below 125 mg/kg, so the no-observed-adverse-effect level was not determined, but the lowest-observed-adverse-effect level was considered to be 125 mg/kg in both sexes and the target organs were found to be the pancreas, eye, and stomach. PMID:25565829

  1. Safety assessment of freeze-dried powdered Tenebrio molitor larvae (yellow mealworm) as novel food source: Evaluation of 90-day toxicity in Sprague-Dawley rats.

    PubMed

    Han, So-Ri; Lee, Byoung-Seok; Jung, Kyung-Jin; Yu, Hee-Jin; Yun, Eun-Young; Hwang, Jae Sam; Moon, Kyoung-Sik

    2016-06-01

    Worldwide demand for novel food source has grown and edible insects are a promising food sources for humans. Tenebrio molitor, as known as yellow mealworm, has advantages of being rich in protein, and easy to raise as a novel food source. The objective of this study was to evaluate subchronic toxicity, including potential hypersensitivity, of freeze-dried powdered T. molitor larvae (fdTML) in male and female Sprague-Dawley rats. The fdTML was administered orally once daily at dose levels of 0, 300, 1000 and 3000 mg/kg/day for 90 days. A toxicological assessment was performed, which included mortality, clinical signs, body and organ weights, food consumption, ophthalmology, urinalysis, hematology, serum chemistry, gross findings, histopathologic examination and allergic reaction. There were no fdTML- related findings in clinical signs, urinalysis, hematology and serum chemistry, gross examination, histopathologic examination or allergic reaction. In conclusion, the No Observed Adverse Effect Level (NOAEL) for fdTML was determined to be in excess of 3000 mg/kg/day in both sexes of rats under the experimental conditions of this study. PMID:26993751

  2. A 90-day study of subchronic oral toxicity of 20 nm, negatively charged zinc oxide nanoparticles in Sprague Dawley rats

    PubMed Central

    Park, Hark-Soo; Shin, Sung-Sup; Meang, Eun Ho; Hong, Jeong-sup; Park, Jong-Il; Kim, Su-Hyon; Koh, Sang-Bum; Lee, Seung-Young; Jang, Dong-Hyouk; Lee, Jong-Yun; Sun, Yle-Shik; Kang, Jin Seok; Kim, Yu-Ri; Kim, Meyoung-Kon; Jeong, Jayoung; Lee, Jong-Kwon; Son, Woo-Chan; Park, Jae-Hak

    2014-01-01

    Purpose The widespread use of nanoparticles (NPs) in industrial and biomedical applications has prompted growing concern regarding their potential toxicity and impact on human health. This study therefore investigated the subchronic, systemic oral toxicity and no-observed-adverse-effect level (NOAEL) of 20 nm, negatively charged zinc oxide (ZnOSM20(−)) NPs in Sprague Dawley rats for 90 days. Methods The high-dose NP level was set at 500 mg/kg of bodyweight, and the mid- and low-dose levels were set at 250 and 125 mg/kg, respectively. The rats were observed during a 14-day recovery period after the last NP administration for the persistence or reduction of any adverse effects. Toxicokinetic and distribution studies were also conducted to determine the systemic distribution of the NPs. Results No rats died during the test period. However, ZnOSM20(−) NPs (500 mg/kg) induced changes in the levels of anemia-related factors, prompted acinar cell apoptosis and ductular hyperplasia, stimulated periductular lymphoid cell infiltration and excessive salivation, and increased the numbers of regenerative acinar cells in the pancreas. In addition, stomach lesions were seen at 125, 250, and 500 mg/kg, and retinal atrophy was observed at 250 and 500 mg/kg. The Zn concentration was dose-dependently increased in the liver, kidney, intestines, and plasma, but not in other organs investigated. Conclusion A ZnOSM20(−) NP NOAEL could not be established from the current results, but the lowest-observed-adverse-effect level was 125 mg/kg. Furthermore, the NPs were associated with a number of undesirable systemic actions. Thus, their use in humans must be approached with caution. PMID:25565828

  3. Report of an Expert Panel on the reanalysis by of a 90-day study conducted by Monsanto in support of the safety of a genetically modified corn variety (MON 863).

    PubMed

    Doull, J; Gaylor, D; Greim, H A; Lovell, D P; Lynch, B; Munro, I C

    2007-11-01

    MON 863, a genetically engineered corn variety that contains the gene for modified Bacillus thuringiensis Cry3Bb1 protein to protect against corn rootworm, was tested in a 90-day toxicity study as part of the process to gain regulatory approval. This study was reanalyzed by Séralini et al. who contended that the study showed possible hepatorenal effects of MON 863. An Expert Panel was convened to assess the original study results as analyzed by the Monsanto Company and the reanalysis conducted by Séralini et al. The Expert Panel concludes that the Séralini et al. reanalysis provided no evidence to indicate that MON 863 was associated with adverse effects in the 90-day rat study. In each case, statistical findings reported by both Monsanto and Séralini et al. were considered to be unrelated to treatment or of no biological or clinical importance because they failed to demonstrate a dose-response relationship, reproducibility over time, association with other relevant changes (e.g., histopathology), occurrence in both sexes, difference outside the normal range of variation, or biological plausibility with respect to cause-and-effect. The Séralini et al. reanalysis does not advance any new scientific data to indicate that MON 863 caused adverse effects in the 90-day rat study.

  4. 75 FR 53615 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition to List the White...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-01

    ... warranted, and initiated a status review (74 FR 36152). This notice constitutes the 12-month finding on the... species under the Act in the 1982 Candidate Notice of Review (47 FR 58454, December 30, 1982). Category 2... for possible addition to the ] Lists of Endangered and Threatened Wildlife and Plants (61 FR...

  5. 76 FR 46251 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the Redrock...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-02

    ... Register on December 16, 2009 (74 FR 66866). This notice constitutes the 12-month finding on the June 18...) crayfish, (4) wildfires, (5) prescribed fires, (6) recreation, and (7) urban and rural development. The potential impacts of nonnative crayfish are discussed here related to habitat alterations, and other...

  6. 76 FR 9991 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List Thorne's...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-23

    ... Hermes copper butterflies in the Federal Register (71 FR 44980 and 71 FR 44966, respectively). The... FR 44980). On March 17, 2009, Center for Biological Diversity (CBD) and David Hogan filed a complaint... butterfly as endangered may be warranted (75 FR 17062). This notice constitutes the 12-month finding on...

  7. 75 FR 1574 - Endangered and Threatened Wildlife and Plants; 12-month Finding on a Petition To Revise Critical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-12

    ... 32256-7517. Please submit any new information, materials, comments, or questions concerning this finding... (Trichechus manatus), as endangered in 1967 (32 FR 4001) under the Endangered Species Preservation Act of 1966... names to the list of foreign endangered species (35 FR 18319). This listing incorporated West...

  8. 75 FR 62070 - Endangered and Threatened Wildlife and Plants; 12-month Finding on a Petition to list the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-07

    ... findings in the Federal Register. Previous Federal Actions Please refer to the final listing rule (64 FR... Notice of Remanded Determination of Status for the Sacramento Splittail (68 FR 55139) for a discussion of... Splittail in the Federal Register (68 FR 55139) that removed the Sacramento splittail from the List...

  9. 78 FR 47277 - Listing Endangered or Threatened Species: 12-Month Finding on a Petition To Delist the Southern...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-05

    .... On November 27, 2012 (77 FR 70733), we made a finding that there was sufficient information...,'' or DPS (61 FR 4722; February 7, 1996). The DPS Policy requires the consideration of two elements when... (67 FR 44133; July 1, 2002). Because of the uncertainties regarding killer whale taxonomy...

  10. 76 FR 37706 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List Castanea...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-28

    ..., diseased, rarely reproductive,'' and from only ``Deciduous Forest.'' Chapman et al. (2006) describe long... publish these 12-month findings in the Federal Register. Previous Federal Actions On July 1, 1975 (40 FR... Service for listing as an endangered species under the Act in 1976 (June 16, 1976, 41 FR 24524)....

  11. 90-day feeding and one-generation reproduction study in Crl:CD BR rats with 17 beta-estradiol.

    PubMed

    Biegel, L B; Flaws, J A; Hirshfield, A N; O'Connor, J C; Elliott, G S; Ladics, G S; Silbergeld, E K; Van Pelt, C S; Hurtt, M E; Cook, J C; Frame, S R

    1998-08-01

    Over the past several years, there has been increasing concern that chemicals and pesticides found in the environment may mimic endogenous estrogens, potentially producing adverse effects in wildlife and human populations. Because estrogenicity is one of the primary concerns, a 90-day/one-generation reproduction study with 17 beta-estradiol was designed to set dose levels for future multigenerational reproduction and combined chronic toxicity/oncogenicity studies. The purpose of these studies is to evaluate the significance of a range of responses as well as to provide benchmark data for a risk assessment for chemicals with estrogen-like activities. This 90-day/one-generation reproduction study was conducted in male and female Crl:CD BR rats using dietary concentrations of 0, 0.05, 2.5, 10, and 50 ppm 17 beta-estradiol. Endpoints were chosen in order to evaluate both subchronic and reproductive toxicity. In addition, several mechanistic/biochemical endpoints were evaluated for their usefulness in follow-up studies. In the P1 generation, dietary administration of 2.5, 10, and 50 ppm 17 beta-estradiol produced dose-dependent decreases in body weight, body weight gain, food consumption, and food efficiency. At 10 and 50 ppm 17 beta-estradiol, minimal to mild nonregenerative anemia, lymphopenia, decreased serum cholesterol (50 ppm only), and altered splenic lymphocyte subtypes were also observed in the P1 generation. Additionally, at these concentrations, there were changes in the weights of several organs. Evidence of ovarian malfunction, characterized by reduced numbers of corpora lutea and large antral follicles, was observed at 2.5 ppm 17 beta-estradiol and above. Other pathologic changes in males and females fed 10 and 50 ppm 17 beta-estradiol included centrilobular hepatocellular hypertrophy; diffuse hyperplasia of the pituitary gland; feminization of the male mammary glands; mammary gland hyperplasia in females; increased number of cystic follicles in the ovary

  12. 7 CFR Appendix B to Subpart C of... - FSA-2510, Notice of Availability of Loan Servicing to Borrowers Who Are 90 Days Past Due

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 7 2011-01-01 2011-01-01 false FSA-2510, Notice of Availability of Loan Servicing to Borrowers Who Are 90 Days Past Due B Appendix B to Subpart C of Part 766 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS DIRECT LOAN SERVICING-SPECIAL Loan...

  13. The Value of ABCD2F Scoring System (ABCD2 Combined with Atrial Fibrillation) to Predict 90-Day Recurrent Brain Stroke

    PubMed Central

    Almasi, Mostafa; Ghasemi, Faeze; Chardoli, Mojtaba

    2016-01-01

    Background. The ABCD2 score is now identified as a useful clinical prediction rule to determine the risk for stroke in the days following brain ischemic attacks. Aim. The present study aimed to introduce a new scoring system named “ABCD2F” and compare its value with the previous ABCD2 system to predict recurrent ischemic stroke within 90 days of the initial cerebrovascular accident (CVA). Methods. 138 consecutive patients with the final diagnosis of ischemic CVA or TIAs who referred to emergency ward of Rasoul-e-Akram general hospital in Tehran from September 2012 to December 2013 were eligible. By adding a new score in the presence of atrial fibrillation to ABCD2 system, the new scoring system as ABCD2F was introduced and the risk stratification was done again on this new system. Results. The area under the curve for ABCD2 was 0.434 and for ABCD2F it was 0.452 indicating low value of both systems for assessing recurrence of stroke within 90 days of primary event. Multivariable logistic regression analysis showed that none of the baseline factors could predict 90-day recurrent stroke. Conclusion. ABCD2 and/or atrial fibrillation are not good scoring candidates for assessing the risk of recurrent stroke within first 90 days. PMID:27642521

  14. The Value of ABCD2F Scoring System (ABCD2 Combined with Atrial Fibrillation) to Predict 90-Day Recurrent Brain Stroke.

    PubMed

    Almasi, Mostafa; Hodjati Firoozabadi, Nader; Ghasemi, Faeze; Chardoli, Mojtaba

    2016-01-01

    Background. The ABCD2 score is now identified as a useful clinical prediction rule to determine the risk for stroke in the days following brain ischemic attacks. Aim. The present study aimed to introduce a new scoring system named "ABCD2F" and compare its value with the previous ABCD2 system to predict recurrent ischemic stroke within 90 days of the initial cerebrovascular accident (CVA). Methods. 138 consecutive patients with the final diagnosis of ischemic CVA or TIAs who referred to emergency ward of Rasoul-e-Akram general hospital in Tehran from September 2012 to December 2013 were eligible. By adding a new score in the presence of atrial fibrillation to ABCD2 system, the new scoring system as ABCD2F was introduced and the risk stratification was done again on this new system. Results. The area under the curve for ABCD2 was 0.434 and for ABCD2F it was 0.452 indicating low value of both systems for assessing recurrence of stroke within 90 days of primary event. Multivariable logistic regression analysis showed that none of the baseline factors could predict 90-day recurrent stroke. Conclusion. ABCD2 and/or atrial fibrillation are not good scoring candidates for assessing the risk of recurrent stroke within first 90 days. PMID:27642521

  15. The Value of ABCD2F Scoring System (ABCD2 Combined with Atrial Fibrillation) to Predict 90-Day Recurrent Brain Stroke

    PubMed Central

    Almasi, Mostafa; Ghasemi, Faeze; Chardoli, Mojtaba

    2016-01-01

    Background. The ABCD2 score is now identified as a useful clinical prediction rule to determine the risk for stroke in the days following brain ischemic attacks. Aim. The present study aimed to introduce a new scoring system named “ABCD2F” and compare its value with the previous ABCD2 system to predict recurrent ischemic stroke within 90 days of the initial cerebrovascular accident (CVA). Methods. 138 consecutive patients with the final diagnosis of ischemic CVA or TIAs who referred to emergency ward of Rasoul-e-Akram general hospital in Tehran from September 2012 to December 2013 were eligible. By adding a new score in the presence of atrial fibrillation to ABCD2 system, the new scoring system as ABCD2F was introduced and the risk stratification was done again on this new system. Results. The area under the curve for ABCD2 was 0.434 and for ABCD2F it was 0.452 indicating low value of both systems for assessing recurrence of stroke within 90 days of primary event. Multivariable logistic regression analysis showed that none of the baseline factors could predict 90-day recurrent stroke. Conclusion. ABCD2 and/or atrial fibrillation are not good scoring candidates for assessing the risk of recurrent stroke within first 90 days.

  16. 7 CFR Appendix B to Subpart C of... - FSA-2510, Notice of Availability of Loan Servicing to Borrowers Who Are 90 Days Past Due

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false FSA-2510, Notice of Availability of Loan Servicing to Borrowers Who Are 90 Days Past Due B Appendix B to Subpart C of Part 766 Agriculture Regulations of the... LOAN SERVICING-SPECIAL Loan Servicing Programs Pt. 766, Subpt. C, App. B Appendix B to Subpart C...

  17. 41 CFR 302-7.9 - What are some reasons that would justify the additional storage beyond the initial 90-day limit?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... that would justify the additional storage beyond the initial 90-day limit? 302-7.9 Section 302-7.9 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES TRANSPORTATION AND STORAGE OF PROPERTY 7-TRANSPORTATION AND TEMPORARY STORAGE OF HOUSEHOLD GOODS AND...

  18. The Model for End-stage Liver Disease accurately predicts 90-day liver transplant wait-list mortality in Atlantic Canada

    PubMed Central

    Renfrew, Paul Douglas; Quan, Hude; Doig, Christopher James; Dixon, Elijah; Molinari, Michele

    2011-01-01

    OBJECTIVE: To determine the generalizability of the predictions for 90-day mortality generated by Model for End-stage Liver Disease (MELD) and the serum sodium augmented MELD (MELDNa) to Atlantic Canadian adults with end-stage liver disease awaiting liver transplantation (LT). METHODS: The predictive accuracy of the MELD and the MELDNa was evaluated by measurement of the discrimination and calibration of the respective models’ estimates for the occurrence of 90-day mortality in a consecutive cohort of LT candidates accrued over a five-year period. Accuracy of discrimination was measured by the area under the ROC curves. Calibration accuracy was evaluated by comparing the observed and model-estimated incidences of 90-day wait-list failure for the total cohort and within quantiles of risk. RESULTS: The area under the ROC curve for the MELD was 0.887 (95% CI 0.705 to 0.978) – consistent with very good accuracy of discrimination. The area under the ROC curve for the MELDNa was 0.848 (95% CI 0.681 to 0.965). The observed incidence of 90-day wait-list mortality in the validation cohort was 7.9%, which was not significantly different from the MELD estimate of 6.6% (95% CI 4.9% to 8.4%; P=0.177) or the MELDNa estimate of 5.8% (95% CI 3.5% to 8.0%; P=0.065). Global goodness-of-fit testing found no evidence of significant lack of fit for either model (Hosmer-Lemeshow χ2 [df=3] for MELD 2.941, P=0.401; for MELDNa 2.895, P=0.414). CONCLUSION: Both the MELD and the MELDNa accurately predicted the occurrence of 90-day wait-list mortality in the study cohort and, therefore, are generalizable to Atlantic Canadians with end-stage liver disease awaiting LT. PMID:21876856

  19. Rheumatoid arthritis is associated with higher 90-day Hospital Readmission Rates Compared to Osteoarthritis after Hip or Knee arthroplasty: A cohort study

    PubMed Central

    Singh, Jasvinder A.; Inacio, Maria C.S.; Namba, Robert S.; Paxton, Elizabeth W.

    2014-01-01

    Objective To examine if an underlying diagnosis of rheumatoid arthritis (RA) or osteoarthritis (OA) impacts the 90-day readmission rates after total hip or knee arthroplasty (THA or TKA). Methods Prospectively collected data from an integrated healthcare system Total Joint Replacement Registry of adults with RA or OA undergoing unilateral primary THA or TKA during 2009-2011 were analyzed. Adjusted logistic regression models for 90-day readmission were fit. Odds ratios with 95% confidence intervals (CI) were calculated. Study year was an effect modifier for the outcome, therefore separate analyses were conducted for each of the three study years. Results Of the 34,311 patients, 496 had RA and 33,815 had OA. Comparing RA and OA, there were: 73% and 61% women; 45% and 70% Caucasians; and the mean age was lower, 61 vs. 67 years (p<0.001). Respective crude 90-day readmission rates were 8.5% and 6.7%. The adjusted odds of 90-day readmission increased from year to year for RA compared to OA patients, from 0.89 (95% CI, 0.46-1.71) in 2009 to 1.34 (95% CI, 0.69-2.61) in 2010 to 1.74 (95% CI, 1.16-2.60) in 2011. The two most common readmission reasons were: joint prosthesis infection (10.2%) and septicemia (10.2%) in RA; joint prosthesis infection (5.7%) and other postoperative infection (5.1%) in OA. Conclusions RA is a risk factor for 90-day readmission after primary TKA or THA. An increasing risk of readmissions noted in RA in 2011 is concerning and indicates further studies should examine the reasons for this increasing trend. PMID:25302697

  20. Vitamin D deficiency at admission is not associated with 90-day mortality in patients with severe sepsis or septic shock: Observational FINNAKI cohort study.

    PubMed

    Ala-Kokko, Tero I; Mutt, Shivaprakash J; Nisula, Sara; Koskenkari, Juha; Liisanantti, Janne; Ohtonen, Pasi; Poukkanen, Meri; Laurila, Jouko J; Pettilä, Ville; Herzig, Karl-Heinz

    2016-01-01

    Introduction Low levels of vitamin D have been associated with increased mortality in patients that are critically ill. This study explored whether vitamin D levels were associated with 90-day mortality in severe sepsis or septic shock. Methods Plasma vitamin D levels were measured on admission to the intensive care unit (ICU) in a prospective multicentre observational study. Results 610 patients with severe sepsis were included; of these, 178 (29%) had septic shock. Vitamin D deficiency (<50 nmol/L) was present in 333 (55%) patients. The 90-day mortality did not differ among patients with or without vitamin D deficiency (28.3% vs. 28.5%, p = 0.789). Diabetes was more common among patients deficient compared to those not deficient in vitamin D (30% vs. 18%, p < 0.001). Hospital-acquired infections at admission were more prevalent in patients with a vitamin D deficiency (31% vs. 16%, p < 0.001). A multivariable adjusted Cox regression model showed that low vitamin D levels could not predict 90-day mortality (<50 nmol/L: hazard ratio (HR) 0.99 (95% CI: 0.72-1.36), p > 0.9; and <25 nmol/L: HR 0.44 (95% CI: 0.22-0.87), p = 0.018). Conclusions Vitamin D deficiency detected upon ICU admission was not associated with 90-day mortality in patients with severe sepsis or septic shock. Key messages In severe sepsis and septic shock, a vitamin D deficiency upon ICU admission was not associated with increased mortality. Compared to patients with sufficient vitamin D, patients with deficient vitamin D more frequently exhibited diabetes, elevated C-reactive protein levels, and hospital-acquired infections upon ICU admission, and they more frequently developed acute kidney injury.

  1. Prior statin use and 90-day mortality in Gram-negative and Gram-positive bloodstream infection: a prospective observational study.

    PubMed

    Mehl, A; Harthug, S; Lydersen, S; Paulsen, J; Åsvold, B O; Solligård, E; Damås, J K; Edna, T-H

    2015-03-01

    In several studies on patients with bloodstream infection (BSI), prior use of statins has been associated with improved survival. Gram-positive and Gram-negative bacteria alert the innate immune system in different ways. We, therefore, studied whether the relation between prior statin use and 90-day total mortality differed between Gram-positive and Gram-negative BSI. We conducted a prospective observational cohort study of 1,408 adults with BSI admitted to Levanger Hospital between January 1, 2002, and December 31, 2011. Data on the use of statins and other medications at admission, comorbidities, functional status, treatment, and outcome were obtained from the patients' hospital records. The relation of statin use with 90-day mortality differed between Gram-negative and Gram-positive BSI (p-value for interaction 0.01). Among patients with Gram-negative BSI, statin users had significantly lower 90-day total mortality [odds ratio (OR) 0.42, 95 % confidence interval (CI) 0.23-0.75, p = 0.003]. The association remained essentially unchanged after adjusting for the effect of sex, age, functional status before the infection, and underlying diseases that were considered confounders (adjusted OR 0.38, 95 % CI 0.20-0.72, p = 0.003). A similar analysis of patients with Gram-positive BSI showed no association of statin use with mortality (adjusted OR 1.22, 95 % CI 0.69-2.17, p = 0.49). The present study suggests that prior statin use is associated with a lower 90-day total mortality in Gram-negative BSI, but not in Gram-positive BSI.

  2. Influence of CO2 change during 90-day experiment on growth characteristics and photosynthetic activity in vegetables grown in Lunar Palace 1

    NASA Astrophysics Data System (ADS)

    Shao, Lingzhi; Liu, Hong; Wang, Minjuan; Fu, Yuming; Dong, Chen; Liu, Guanghui

    To establish bioregenerative life support system (BLSS) on lunar or Mars bases in the future, it is necessary to firstly conduct manned simulation experiments on the ground. For this purpose, Lunar palace 1 as an integrative experimental facility for permanent astrobase life support artificial closed ecosystem was set up, and 90-day experiment was carried out in this system. Vegtables as one of the important plant units, provide various nutrient content for crews in the system, such as vitamin, antioxidants and so on. However, it is not clear yet that how the CO _{2} change during 90-day experiment to affect on growth characteristics and photosynthetic activity in vegtables grown in the system. In this study, red lettuce, red rape, romaine lettuce, and bibb lettuce grown in the system were chosen as the subject investigated. Growth, expressed as dry weight, length of shoot and root, leaf area, was mearsured, and photosynthesis,expressed as net photosynthetic rate, intercellular CO _{2} concentration, chlorophyll contents and fluorescence was analyzed to detemind influence of CO _{2} change during 90-day experiment on growth in vegtables grown in the system.

  3. A 90-day safety study of genetically modified rice expressing rhIGF-1 protein in C57BL/6J rats.

    PubMed

    Tang, Maoxue; Xie, Tingting; Cheng, Wenke; Qian, Lili; Yang, Shulin; Yang, Daichang; Cui, Wentao; Li, Kui

    2012-06-01

    Genetically modified plants expressing disease resistance traits offer new treatment strategies for human diseases, but at the same time present a challenge in terms of food safety assessment. The present 90-day feeding study was designed to assess the safety of transgenic rice expressing the recombinant human insulin-like growth factor-1 (rhIGF-1) compared to its parental wild rice. Male and female C57BL/6J rats were given a nutritionally balanced purified diet with 20% transgenic rhIGF-1 rice or 20% parental rice for 90 days. This corresponds to a mean daily rhIGF-1 protein intake of approximately 217.6 mg/kg body weight based on the average feed consumption. In the animal study a range of biological, biochemical, clinical, microbiological and pathological parameters were examined and several significant differences were observed between groups, but none of the effects were considered to be adverse. In conclusion, no adverse or toxic effects on C57BL/6J rats were observed in the design used in this 90-day study. These results will provide valuable information for the safety assessment of genetically modified food crops.

  4. A 90-day safety study in Sprague-Dawley rats fed milk powder containing recombinant human lactoferrin (rhLF) derived from transgenic cloned cattle.

    PubMed

    Zhou, Cui; Wang, Jian Wu; Huang, Kun Lun; He, XiaoYun; Chen, Xiu Ping; Sun, Hong; Yu, Tian; Che, Hui Lian

    2011-10-01

    Transgenic cloned animals expressing beneficial human nutritional traits offer a new strategy for large-scale production of some kinds of functional substances. In some cases, the required safety testing for genetically modified (GM) foods do not seem appropriate for human food safety, though regulations do not seem to provide alternatives. A 90-day rat feeding study is the core study for the safety assessment of GM foods. The test material in this 90-day study was prepared nonfat milk powder containing recombinant human lactoferrin (rhLF), which was expressed in transgenic cloned cattle. Groups of 10 male and female Sprague-Dawley rats were given a nutritionally balanced purified diet containing 7.5, 15, or 30% transgenic or conventional milk powder for 90 days. A commercial AIN93G diet was used as an additional control group. Clinical, biological, and pathological parameters were compared between groups. The only significant effect of treatment was higher mean ferritin and Fe(+) concentrations for both male and female rats fed the transgenic milk powder diets, as compared to rats fed nontransgenic milk diets or the commercial diet. The results of the present study are consistent with previous research, which indicates that milk powder containing rhLF derived from healthy transgenic cloned cattle is as safe as conventional milk powder.

  5. Study of the reproductive effects in rats surgically implanted with depleted uranium for up to 90 days.

    PubMed

    Arfsten, D P; Bekkedal, M; Wilfong, E R; Rossi, J; Grasman, K A; Healey, L B; Rutkiewicz, J M; Johnson, E W; Thitoff, A R; Jung, A E; Lohrke, S R; Schaeffer, D J; Still, K R

    In 2001, the Naval Health Research Center Toxicology Detachment was funded by the U.S. Army Medical Research Acquisition Activity (USAMRAA) to conduct a study of the effects of surgically implanted depleted uranium (DU) pellets on adult rat reproductive success and development across two successive generations. This article presents some of the findings for the group of offspring from adult rats mated at 30 d post surgical implantation of DU pellets. Adult male and female Sprague-Dawley rats (P1 generation) were surgically implanted with 0, 4, 8, or 12 DU pellets (1 x 2 mm). The P1 generation was then cross-mated at 30 d post surgical implantation. Urine collected from P1 animals at 27 d post surgical implantation showed that DU was excreted in the urine of DU-implanted animals in a dose-dependent manner. DU surgical implantation did not have a negative impact on P1 reproductive success, survival, or body weight gain through post surgical implantation d 90. There were no statistically significant differences in F1 birth weight, survival, and litter size at postnatal day (PND) 0, 5, and 20. No gross physical abnormalities identified in the offspring were attributable to neonatal DU exposure. A series of neurodevelopment and immune function assessments were also conducted on F1 offspring. No group differences were observed that were related to parental DU exposure. Studies are ongoing on the impact of leaving DU embedded in soft tissue for 120 d on rat reproduction and subsequent offspring survival and development.

  6. Comparative safety testing of genetically modified foods in a 90-day rat feeding study design allowing the distinction between primary and secondary effects of the new genetic event.

    PubMed

    Knudsen, Ib; Poulsen, Morten

    2007-10-01

    This article discusses the wider experiences regarding the usefulness of the 90-day rat feeding study for the testing of whole foods from genetically modified (GM) plant based on data from a recent EU-project [Poulsen, M., Schrøder, M., Wilcks, A., Kroghsbo, S., Lindecrona, R.H., Miller, A., Frenzel, T., Danier, J., Rychlik, M., Shu, Q., Emami, K., Taylor, M., Gatehouse, A., Engel, K.-H., Knudsen, I., 2007a. Safety testing of GM-rice expressing PHA-E lectin using a new animal test design. Food Chem. Toxicol. 45, 364-377; Poulsen, M., Kroghsbo, S., Schrøder, M., Wilcks, A., Jacobsen, H., Miller, A., Frenzel, T., Danier, J., Rychlik, M., Shu, Q., Emami, K., Sudhakar, D., Gatehouse, A., Engel, K.-H., Knudsen, I., 2007b. A 90-day safety in Wistar rats fed genetically modified rice expressing snowdrop lectin Galanthus nivalis (GNA). Food Chem. Toxicol. 45, 350-363; Schrøder, M., Poulsen, M., Wilcks, A., Kroghsbo, S., Miller, A., Frenzel, T., Danier, J., Rychlik, M., Emami, K., Gatehouse, A., Shu, Q., Engel, K.-H., Knudsen, I., 2007. A 90-day safety study of genetically modified rice expressing Cry1Ab protein (Bacillus thuringiensis toxin) in Wistar rats. Food Chem. Toxicol. 45, 339-349]. The overall objective of the project has been to develop and validate the scientific methodology necessary for assessing the safety of foods from genetically modified plants in accordance with the present EU regulation. The safety assessment in the project is combining the results of the 90-day rat feeding study on the GM food with and without spiking with the pure novel gene product, with the knowledge about the identity of the genetic change, the compositional data of the GM food, the results from in-vitro/ex-vivo studies as well as the results from the preceding 28-day toxicity study with the novel gene product, before the hazard characterisation is concluded. The results demonstrated the ability of the 90-day rat feeding study to detect the biological/toxicological effects of the

  7. STS-90 Day 14 Highlights

    NASA Technical Reports Server (NTRS)

    1998-01-01

    On this fourteenth day of the STS-90 mission, the flight crew, Cmdr. Richard A. Searfoss, Pilot Scott D. Altman, and Mission Specialists Richard M. Linnehan, Dafydd Rhys Williams and Kathryn P. Hire, and Payload Specialists Jay C. Buckey and James A. Pawelczyk focus on the efforts of Neurolab's Neuronal Plasticity Team to better understand how the adult nervous system adapts to the new environment of space. Columbia's science crew -- Mission Specialists Rick Linnehan and Dave Williams and Payload Specialists Jay Buckey and Jim Pawelczyk -- perform the second and final in-flight dissections of the adult male rats on board. The crew euthanizes and dissects nine rats and remove the vestibular or balance organs of the inner ear; the cerebellum, the part of the brain critical for maintaining balance and for processing information from the limbs so they can be moved smoothly; and the cerebrum, one part of which controls automatic functions such as body temperature regulation and the body's internal clock, and the cortical region that controls cognitive functions such as thinking. The first dissection, which was performed on the second day of the flight, went extremely well, according to Neurolab scientists.

  8. STS-90 Day 01 Highlights

    NASA Technical Reports Server (NTRS)

    1998-01-01

    On this first day of the STS-90 mission, the flight crew, Cmdr. Richard A. Searfoss, Pilot Scott D. Altman, and Mission Specialists Richard M. Linnehan, Dafydd Rhys Williams and Kathryn P. Hire, and Payload Specialists Jay C. Buckey and James A. Pawelczyk, can be seen performing pre-launch activities such as eating the traditional breakfast, crew suit-up, and the ride out to the launch pad. Also, included are various panoramic views of the shuttle on the pad. The crew is readied in the white room' for their mission. After the closing of the hatch and arm retraction, launch activities are shown including countdown, engine ignition, launch, and the separation of the Solid Rocket Boosters. The shuttle's payload bay doors are then opened in anticipation of the 16-day scientific mission. The astronauts then are seen readying the Spacelab module for various experiments.

  9. STS-90 Day 05 Highlights

    NASA Technical Reports Server (NTRS)

    1998-01-01

    On this fifth day of the STS-90 mission, the flight crew, Cmdr. Richard A. Searfoss, Pilot Scott D. Altman, and Mission Specialists Richard M. Linnehan, Dafydd Rhys Williams and Kathryn P. Hire, and Payload Specialists Jay C. Buckey and James A. Pawelczyk perform tests associated with the STS-90 Neurolab Vestibular Team's efforts to gain insight into the balance organs in the ear and all the connections that system has to the eyes, brain, and muscles in adapting to the weightless condition in space and then readapts to the gravity environment found on Earth.

  10. Safety assessment of the fermented Phylloporia ribis (Lonicera japonica Thunb.) mycelia by oral acute toxicity study in mice and 90-day feeding study in rats.

    PubMed

    Lu, Lianhua; Fan, Yiou; Yao, Wenhuan; Xie, Wei; Guo, Jie; Yan, Yan; Yang, Fei; Xu, Lingchuan

    2014-07-01

    Phylloporia ribis is an edible fungus in China. Its fermented mycelia have been approved by the National Health and Family Planning Commission (NHFPC) of PR China for use as a novel food material, but little information on its safety is available. The present research was the first to evaluate acute and subchronic toxicity in experimental animals of fermented Phylloporia ribis mycelia (FPM) following standard procedures. In acute toxicity study, FPM was orally administered to male and female mice twice a day at single dose of 10 g/kg bw. The Maximum Tolerated Dose (MTD) of FPM for mice of both sexes was over 10 g/kg bw. No death and abnormal behaviors occurred during 14 days study except for an increased locomotor activity in three animals. In 90-day feeding study, male and female Sprague-Dawley rats were fed diets containing 10.0%, 5.0%, 2.5%, 1.25% and 0% (control) FPM for 90 days. The treatment caused no effects on mortality, gross pathology, histology, hematology, and blood chemistry, no dose-dependent changes in food consumption, but caused effect on body weight gain compared with control group. The No Observed Adverse-Effect Level (NOAEL) of FPM was greater than 8.7 g/kg bw/day in both sexes of rats.

  11. A 90-Day Dietary Toxicity Study of Genetically Modified Rice T1C-1 Expressing Cry1C Protein in Sprague Dawley Rats

    PubMed Central

    Tang, Xueming; Han, Fangting; Zhao, Kai; Xu, Yan; Wu, Xiao; Wang, Jinbin; Jiang, Lingxi; Shi, Wei

    2012-01-01

    In a 90-day study, Sprague Dawley rats were fed transgenic T1C-1 rice expressing Cry1C protein and were compared with rats fed non-transgenic parental rice Minghui 63 and rats fed a basal diet. No adverse effects on animal behavior or weight gain were observed during the study. Blood samples were collected and analyzed, and standard hematological and biochemical parameters were compared. A few of these parameters were found to be significantly different, but were within the normal reference intervals for rats of this breed and age, and were thus not considered to be treatment-related. Following sacrifice, a large number of organs were weighed, and macroscopic and histopathological examinations were performed with no changes reported. The aim of this study was to use a known animal model to determine the safety of the genetically modified (GM) rice T1C-1. The results showed no adverse or toxic effects due to T1C-1 rice when tested in this 90-day study. PMID:23300690

  12. Evaluation of the safety and nutritional equivalence of a genetically modified cottonseed meal in a 90-day dietary toxicity study in rats.

    PubMed

    Dryzga, M D; Yano, B L; Andrus, A K; Mattsson, J L

    2007-10-01

    Meal prepared from Cry1F/Cry1Ac transgenic/genetically modified cottonseed (WIDESTRIKE Insect Protection, hereafter referred to as WIDESTRIKE) was compared to cottonseed meal prepared from four conventionally bred lines of cotton (three commercial non-transgenic line controls (PHY72, PHY78 and 98M-2983), and a near isoline non-transgenic control (PSC355) in a 90-day dietary study to evaluate safety and nutritional equivalence. Diets were formulated with 10% WIDESTRIKE cottonseed meal equivalent to 7,235 mg/kg/day for males and 7,935 mg/kg/day for females. Animals were evaluated by cage-side and hand-held detailed clinical observations, body weight, and feed consumption. Functional tests, motor activity and ophthalmic examinations were conducted pre-exposure and prior to study termination. Standard hematology, clinical chemistry, prothrombin time and urinalysis parameters were evaluated. All rats had a complete necropsy and selected organs were weighed. Histopathologic examinations were performed on all rats fed the diets containing the near isoline non-transgenic control or WIDESTRIKE. Following 90 days of feeding, no adverse effects were observed during the conduct of clinical observations or in any of the parameters measured in this study. This study demonstrated that rodent diets prepared with 10% cottonseed meal from WIDESTRIKE cottonseeds do not produce any untoward effects and are nutritionally equivalent to cottonseed meals prepared from other, non-transgenic cottonseeds.

  13. A 90-day dietary toxicity study of genetically modified rice T1C-1 expressing Cry1C protein in Sprague Dawley rats.

    PubMed

    Tang, Xueming; Han, Fangting; Zhao, Kai; Xu, Yan; Wu, Xiao; Wang, Jinbin; Jiang, Lingxi; Shi, Wei

    2012-01-01

    In a 90-day study, Sprague Dawley rats were fed transgenic T1C-1 rice expressing Cry1C protein and were compared with rats fed non-transgenic parental rice Minghui 63 and rats fed a basal diet. No adverse effects on animal behavior or weight gain were observed during the study. Blood samples were collected and analyzed, and standard hematological and biochemical parameters were compared. A few of these parameters were found to be significantly different, but were within the normal reference intervals for rats of this breed and age, and were thus not considered to be treatment-related. Following sacrifice, a large number of organs were weighed, and macroscopic and histopathological examinations were performed with no changes reported. The aim of this study was to use a known animal model to determine the safety of the genetically modified (GM) rice T1C-1. The results showed no adverse or toxic effects due to T1C-1 rice when tested in this 90-day study.

  14. A 90-day subchronic feeding study of genetically modified maize expressing Cry1Ac-M protein in Sprague-Dawley rats.

    PubMed

    Liu, Pengfei; He, Xiaoyun; Chen, Delong; Luo, Yunbo; Cao, Sishuo; Song, Huan; Liu, Ting; Huang, Kunlun; Xu, Wentao

    2012-09-01

    The cry1Ac-M gene, coding one of Bacillus thuringiensis (Bt) crystal proteins, was introduced into maize H99 × Hi IIB genome to produce insect-resistant GM maize BT-38. The food safety assessment of the BT-38 maize was conducted in Sprague-Dawley rats by a 90-days feeding study. We incorporated maize grains from BT-38 and H99 × Hi IIB into rodent diets at three concentrations (12.5%, 25%, 50%) and administered to Sprague-Dawley rats (n=10/sex/group) for 90 days. A commercialized rodent diet was fed to an additional group as control group. Body weight, feed consumption and toxicological response variables were measured, and gross as well as microscopic pathology were examined. Moreover, detection of residual Cry1Ac-M protein in the serum of rats fed with GM maize was conducted. No death or adverse effects were observed in the current feeding study. No adverse differences in the values of the response variables were observed between rats that consumed diets containing GM maize BT-38 and non-GM maize H99 × Hi IIB. No detectable Cry1Ac-M protein was found in the serum of rats after feeding diets containing GM maize for 3 months. The results demonstrated that BT-38 maize is as safe as conventional non-GM maize.

  15. A 90-day feeding study of glyphosate-tolerant maize with the G2-aroA gene in Sprague-Dawley rats.

    PubMed

    Zhu, Yaxi; He, Xiaoyun; Luo, Yunbo; Zou, Shiying; Zhou, Xin; Huang, Kunlun; Xu, Wentao

    2013-01-01

    Maize is not only a staple food crop but also an important raw material for feed and industry; however, the threat of weeds leads to a serious decline in its output and quality. The G2-aroA gene confers glyphosate herbicide tolerance to crops. In this study, the food safety of genetically modified (GM), glyphosate-tolerant maize with the G2-aroA gene was evaluated in a 90-day feeding study in Sprague-Dawley (SD) rats. Maize grain from GM or non-GM isogenic control lines were separately formulated into rodent diets at concentrations of 12.5% (low level), 25% (middle level), and 50% (high level). An additional group of rats were fed a commercialized diet as a control. The toxicological response variables, including body weights, food consumption, serum biochemistry, hematology, and absolute and relative organ weights, were compared between rats fed GM maize and those fed non-GM maize after consumption of test diets for 90days. In addition, gross and microscopic pathology were conducted among treatment groups. No adverse effects related to the consumption of GM maize were detected in the subchronic feeding study. These results indicated that the GM glyphosate-tolerant maize was as safe and nutritious as conventional maize.

  16. Findings

    MedlinePlus

    ... Issue All Issues Explore Findings by Topic Cell Biology Cellular Structures, Functions, Processes, Imaging, Stress Response Chemistry ... Glycobiology, Synthesis, Natural Products, Chemical Reactions Computers in Biology Bioinformatics, Modeling, Systems Biology, Data Visualization Diseases Cancer, ...

  17. 29 CFR 6.57 - Petition for review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Board pursuant to 29 CFR part 8. The petition shall refer to the specific findings of fact, conclusions... FEDERALLY ASSISTED CONSTRUCTION CONTRACTS AND FEDERAL SERVICE CONTRACTS Substantial Variance and Arm's Length Proceedings § 6.57 Petition for review. Within 10 days after the date of the decision of...

  18. 29 CFR 6.57 - Petition for review.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Board pursuant to 29 CFR part 8. The petition shall refer to the specific findings of fact, conclusions... FEDERALLY ASSISTED CONSTRUCTION CONTRACTS AND FEDERAL SERVICE CONTRACTS Substantial Variance and Arm's Length Proceedings § 6.57 Petition for review. Within 10 days after the date of the decision of...

  19. 29 CFR 6.57 - Petition for review.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Board pursuant to 29 CFR part 8. The petition shall refer to the specific findings of fact, conclusions... FEDERALLY ASSISTED CONSTRUCTION CONTRACTS AND FEDERAL SERVICE CONTRACTS Substantial Variance and Arm's Length Proceedings § 6.57 Petition for review. Within 10 days after the date of the decision of...

  20. 29 CFR 6.57 - Petition for review.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Board pursuant to 29 CFR part 8. The petition shall refer to the specific findings of fact, conclusions... FEDERALLY ASSISTED CONSTRUCTION CONTRACTS AND FEDERAL SERVICE CONTRACTS Substantial Variance and Arm's Length Proceedings § 6.57 Petition for review. Within 10 days after the date of the decision of...

  1. Effect of complications within 90 days on patient-reported outcomes 3 months and 12 months following elective surgery for lumbar degenerative disease.

    PubMed

    Chotai, Silky; Parker, Scott L; Sivaganesan, Ahilan; Sielatycki, J Alex; Asher, Anthony L; McGirt, Matthew J; Devin, Clinton J

    2015-12-01

    OBJECT There is a paradigm shift toward rewarding providers for quality rather than volume. Complications appear to occur at a fairly consistent frequency in large aggregate data sets. Understanding how complications affect long-term patient-reported outcomes (PROs) following degenerative lumbar surgery is vital. The authors hypothesized that 90-day complications would adversely affect long-term PROs. METHODS Nine hundred six consecutive patients undergoing elective surgery for degenerative lumbar disease over a period of 4 years were enrolled into a prospective longitudinal registry. The following PROs were recorded at baseline and 12-month follow-up: Oswestry Disability Index (ODI) score, numeric rating scales for back and leg pain, quality of life (EQ-5D scores), general physical and mental health (SF-12 Physical Component Summary [PCS] and Mental Component Summary [MCS] scores) and responses to the North American Spine Society (NASS) satisfaction questionnaire. Previously published minimum clinically important difference (MCID) threshold were used to define meaningful improvement. Complications were divided into major (surgicalsite infection, hardware failure, new neurological deficit, pulmonary embolism, hematoma and myocardial infarction) and minor (urinary tract infection, pneumonia, and deep venous thrombosis). RESULTS Complications developed within 90 days of surgery in 13% (118) of the patients (major in 12% [108] and minor in 8% [68]). The mean improvement in ODI scores, EQ-5D scores, SF-12 PCS scores, and satisfaction at 3 months after surgery was significantly less in the patients with complications than in those who did not have major complications (ODI: 13.5 ± 21.2 vs 21.7 ± 19, < 0.0001; EQ-5D: 0.17 ± 0.25 vs 0.23 ± 0.23, p = 0.04; SF-12 PCS: 8.6 ± 13.3 vs 13.0 ± 11.9, 0.001; and satisfaction: 76% vs 90%, p = 0.002). At 12 months after surgery, the patients with major complications had higher ODI scores than those without complications (29.1

  2. Effect of complications within 90 days on patient-reported outcomes 3 months and 12 months following elective surgery for lumbar degenerative disease.

    PubMed

    Chotai, Silky; Parker, Scott L; Sivaganesan, Ahilan; Sielatycki, J Alex; Asher, Anthony L; McGirt, Matthew J; Devin, Clinton J

    2015-12-01

    OBJECT There is a paradigm shift toward rewarding providers for quality rather than volume. Complications appear to occur at a fairly consistent frequency in large aggregate data sets. Understanding how complications affect long-term patient-reported outcomes (PROs) following degenerative lumbar surgery is vital. The authors hypothesized that 90-day complications would adversely affect long-term PROs. METHODS Nine hundred six consecutive patients undergoing elective surgery for degenerative lumbar disease over a period of 4 years were enrolled into a prospective longitudinal registry. The following PROs were recorded at baseline and 12-month follow-up: Oswestry Disability Index (ODI) score, numeric rating scales for back and leg pain, quality of life (EQ-5D scores), general physical and mental health (SF-12 Physical Component Summary [PCS] and Mental Component Summary [MCS] scores) and responses to the North American Spine Society (NASS) satisfaction questionnaire. Previously published minimum clinically important difference (MCID) threshold were used to define meaningful improvement. Complications were divided into major (surgicalsite infection, hardware failure, new neurological deficit, pulmonary embolism, hematoma and myocardial infarction) and minor (urinary tract infection, pneumonia, and deep venous thrombosis). RESULTS Complications developed within 90 days of surgery in 13% (118) of the patients (major in 12% [108] and minor in 8% [68]). The mean improvement in ODI scores, EQ-5D scores, SF-12 PCS scores, and satisfaction at 3 months after surgery was significantly less in the patients with complications than in those who did not have major complications (ODI: 13.5 ± 21.2 vs 21.7 ± 19, < 0.0001; EQ-5D: 0.17 ± 0.25 vs 0.23 ± 0.23, p = 0.04; SF-12 PCS: 8.6 ± 13.3 vs 13.0 ± 11.9, 0.001; and satisfaction: 76% vs 90%, p = 0.002). At 12 months after surgery, the patients with major complications had higher ODI scores than those without complications (29.1

  3. Collagen content in the vastus lateralis and the soleus muscle following a 90-day bed rest period with or without resistance exercises

    PubMed Central

    Nielsen, Rasmus Oestergaard; Schjerling, Peter; Tesch, Per; Stål, Per; Langberg, Henning

    2015-01-01

    Summary Introduction spaceflight seems associated with deterioration of the function of the skeletal muscles. Since muscle collagen is critical for muscle function, an improved understanding of the content of the muscle collagen during long-term inactivity seems important. Bed-rest with in-bed resistance training serves as a proxy for the conditions in space. Therefore, ground-based studies may improve the understanding of the consequences of long-term inactivity. Purpose the purpose is to compare the change in collagen protein in the vastus lateralis (VL) and the soleus (SOL) muscle amongst persons exposed to a 90-day bed rest with or without resistance exercise. Methods an explorative analysis was completed based on data from a randomized, controlled trial. The intervention group (BRE, SOL n=4, VL n=8) performed supine-based squat exercises, whereas the controls (BE, SOL n=6, VL n=12) remained inactive during follow-up. Muscle biopsies from vastus lateralis and soleus were taken at baseline (pre) and after 90-days’ follow-up (post). Muscle collagen (μg collagen/mg protein) was quantified. Two-way repeated measurements ANOVA was used to compare the interaction between the intervention (BRE/BR) and time (pre/post) for each muscle. Results the collagen content of VL was similar between pre and post in the BRE group (−3.8 μg collagen/mg protein [95% CI: −22.0; 14.4], p=0.68) while it rose amongst individuals in the BR group (14.9 μg collagen/mg protein [95% CI: −0.01; 29.7], p=0.05). The difference of 18.66 [95% CI: −6.5; 43.9] between BRE and BR across time was, however, not significant (p=0.14). No significant reduction in SOL muscle collagen content was observed from pre to post in the BR group (−9.3 μg collagen/mg protein [95% CI: −24.9; 6.4], p=0.25) or in the BRE group (−6.5 μg collagen/mg protein [95% CI: −25.6; 12.6], p=0.50). There was no difference in the effect of BR versus BRE over time (mean difference −2.78 μg collagen

  4. In vivo genotoxicity evaluation of lung cells from Fischer 344 rats following 28 days of inhalation exposure to MWCNTs, plus 28 days and 90 days post-exposure.

    PubMed

    Kim, Jin Sik; Sung, Jae Hyuck; Choi, Byung Gil; Ryu, Hyeon Yeol; Song, Kyung Seuk; Shin, Jae Hoon; Lee, Jong Seong; Hwang, Joo Hwan; Lee, Ji Hyun; Lee, Gun Ho; Jeon, Kisoo; Ahn, Kang Ho; Yu, Il Je

    2014-03-01

    Despite their useful physico-chemical properties, carbon nanotubes (CNTs) continue to cause concern over occupational and human health due to their structural similarity to asbestos. Thus, to evaluate the toxic and genotoxic effect of multi-wall carbon nanotubes (MWCNTs) on lung cells in vivo, eight-week-old rats were divided into four groups (each group = 25 animals), a fresh air control (0 mg/m(3)), low (0.17 mg/m(3)), middle (0.49 mg/m(3)), and high (0.96 mg/m(3)) dose group, and exposed to MWCNTs via nose-only inhalation 6 h per day, 5 days per week for 28 days. The count median length and geometric standard deviation for the MWCNTs determined by TEM were 330.18 and 1.72 nm, respectively, and the MWCNT diameters ranged from 10 to 15 nm. Lung cells were isolated from five male and five female rats in each group on day 0, day 28 (only from males) and day 90 following the 28-day exposure. The total number of animals used was 15 male and 10 female rats for each concentration group. To determine the genotoxicity of the MWCNTs, a single cell gel electrophoresis assay (Comet assay) was conducted on the rat lung cells. As a result of the exposure, the olive tail moments were found to be significantly higher (p < 0.05) in the male and female rats from all the exposed groups when compared with the fresh air control. In addition, the high-dose exposed male and middle and high-dose exposed female rats retained DNA damage, even 90 days post-exposure (p < 0.05). To investigate the mode of genotoxicity, the intracellular reactive oxygen species (ROS) levels and inflammatory cytokine levels (TNF-α, TGF- β, IL-1, IL-2, IL-4, IL-5, IL-10, IL-12 and IFN-γ) were also measured. For the male rats, the H2O2 levels were significantly higher in the middle (0 days post-exposure) and high- (0 days and 28 days post-exposure) dose groups (p < 0.05). Conversely, the female rats showed no changes in the H2O2 levels. The inflammatory cytokine levels in the

  5. Cariogram outcome after 90 days of oral treatment with Streptococcus salivarius M18 in children at high risk for dental caries: results of a randomized, controlled study

    PubMed Central

    Di Pierro, Francesco; Zanvit, Alberto; Nobili, Piero; Risso, Paolo; Fornaini, Carlo

    2015-01-01

    Dental caries is the most common chronic disease of childhood. Cariogram is a well-recognized algorithm-based software program based on different caries-related risk factors and intended to aid clinicians in performing more objective and consistent dental caries risk assessments. This type of approach precedes the diagnosis of caries and allows the dentist to identify at-risk patients and then take appropriate preventive measures before caries develop further. One of the etiological factors favoring the development of dental caries is the mutans streptococci. These acidogenic dental plaque inhabitants can be effectively antagonized by the activity of bacteriocins released by the probiotic Streptococcus salivarius M18 (salivarius M18). Moreover, salivarius M18 after colonizing the human oral mucosa produces the enzymes dextranase and urease that are able to counteract plaque formation and saliva acidity, respectively. Seventy-six subjects at high risk of dental caries were randomized and then either treated or not treated for 90 days with an oral formulation containing the oral probiotic salivarius M18 (Carioblis®). The results indicate that the use of salivarius M18 increases the chances of avoiding new dental caries development in children, and its application could be proposed as a new tool in the dentist’s armory to be adopted in subjects considered at high risk on the basis of their Cariogram outcome. PMID:26491371

  6. Safety assessment of SDA soybean oil: results of a 28-day gavage study and a 90-day/one generation reproduction feeding study in rats.

    PubMed

    Hammond, Bruce G; Lemen, Joan K; Ahmed, Gulam; Miller, Kathleen D; Kirkpatrick, Jeannie; Fleeman, Tammye

    2008-12-01

    Long chain polyunsaturated fatty acids (LC-PUFAs) in the diet reduce risk of cardiac mortality. Fish oils are a dietary source of LC-PUFAs (EPA, DHA) but intake is low in Western diets. Adding beneficial amounts of LC-PUFAs to foods is limited by their instability and potential to impart off-flavors. Stearidonic acid (SDA), a precursor of EPA in man, is more stable than EPA/DHA in food matrices. SDA is present in fish oils (0.5-4%) and in nutraceuticals (echium, borage oil). Genes for Delta6, Delta15 desaturases were introduced into soybeans that convert linoleic and alpha-linolenic acid to SDA (15-30% fatty acids). Since addition of SDA soybean oil into human foods increases SDA intake, toxicology studies were undertaken to assess its safety. In a 28-day pilot study, rats were gavaged with SDA soybean oil at dosages up to 3g/kg body weight/day; no treatment-related adverse effects were observed. A 90-day/one generation rat reproduction study was subsequently conducted where SDA soybean oil was added to diets to provide daily doses of 1.5 and 4 g/kg body weight. There were no treatment-related adverse effects on parental animals or on reproductive performance and progeny development. PMID:18804141

  7. A 90 day safety assessment of genetically modified rice expressing Cry1Ab/1Ac protein using an aquatic animal model.

    PubMed

    Zhu, Hao-Jun; Chen, Yi; Li, Yun-He; Wang, Jia-Mei; Ding, Jia-Tong; Chen, Xiu-Ping; Peng, Yu-Fa

    2015-04-15

    In fields of transgenic Bt rice, frogs are exposed to Bt proteins through consumption of both target and nontarget insects. In the present study, we assessed the risk posed by transgenic rice expressing a Cry1Ab/1Ac fusion protein (Huahui 1, HH1) on the development of Xenopus laevis. For 90 days, froglets were fed a diet with 30% HH1 rice, 30% parental rice (Minghui 63, MH63), or no rice as a control. Body weight and length were measured every 15 days. After sacrificing the froglets, we performed a range of biological, clinical, and pathological assessments. No significant differences were found in body weight (on day 90: 27.7 ± 2.17, 27.4 ± 2.40, and 27.9 ± 1.67 g for HH1, MH63, and control, respectively), body length (on day 90: 60.2 ± 1.55, 59.3 ± 2.33, and 59.7 ± 1.64 mm for HH1, MH63, and control, respectively), animal behavior, organ weight, liver and kidney function, or the microstructure of some tissues between the froglets fed on the HH1-containing diet and those fed on the MH63-containing or control diets. This indicates that frog development was not adversely affected by dietary intake of Cry1Ab/1Ac protein. PMID:25822065

  8. Assessment of the reporting of quality and outcome measures in hepatic resections: a call for 90-day reporting in all hepatectomy series

    PubMed Central

    Egger, Michael E; Ohlendorf, Joanna M; Scoggins, Charles R; McMasters, Kelly M; Martin, Robert C G

    2015-01-01

    Background The aim of this paper is to assess the current state of quality and outcomes measures being reported for hepatic resections in the recent literature. Methods Medline and PubMed databases were searched for English language articles published between 1 January 2002 and 30 April 2013. Two examiners reviewed each article and relevant citations for appropriateness of inclusion, which excluded papers of liver donor hepatic resections, repeat hepatectomies or meta-analyses. Data were extracted and summarized by two examiners for analysis. Results Fifty-five studies were identified with suitable reporting to assess peri-operative mortality in hepatic resections. In only 35% (19/55) of the studies was the follow-up time explicitly stated, and in 47% (26/55) of studies peri-operative mortality was limited to in-hospital or 30 days. The time period in which complications were captured was not explicitly stated in 19 out of 28 studies. The remaining studies only captured complications within 30 days of the index operation (8/28). There was a paucity of quality literature addressing truly patient-centred outcomes. Conclusion Quality outcomes after a hepatic resection are inconsistently reported in the literature. Quality outcome studies for a hepatectomy should report mortality and morbidity at a minimum of 90 days after surgery. PMID:26228262

  9. Cariogram outcome after 90 days of oral treatment with Streptococcus salivarius M18 in children at high risk for dental caries: results of a randomized, controlled study.

    PubMed

    Di Pierro, Francesco; Zanvit, Alberto; Nobili, Piero; Risso, Paolo; Fornaini, Carlo

    2015-01-01

    Dental caries is the most common chronic disease of childhood. Cariogram is a well-recognized algorithm-based software program based on different caries-related risk factors and intended to aid clinicians in performing more objective and consistent dental caries risk assessments. This type of approach precedes the diagnosis of caries and allows the dentist to identify at-risk patients and then take appropriate preventive measures before caries develop further. One of the etiological factors favoring the development of dental caries is the mutans streptococci. These acidogenic dental plaque inhabitants can be effectively antagonized by the activity of bacteriocins released by the probiotic Streptococcus salivarius M18 (salivarius M18). Moreover, salivarius M18 after colonizing the human oral mucosa produces the enzymes dextranase and urease that are able to counteract plaque formation and saliva acidity, respectively. Seventy-six subjects at high risk of dental caries were randomized and then either treated or not treated for 90 days with an oral formulation containing the oral probiotic salivarius M18 (Carioblis(®)). The results indicate that the use of salivarius M18 increases the chances of avoiding new dental caries development in children, and its application could be proposed as a new tool in the dentist's armory to be adopted in subjects considered at high risk on the basis of their Cariogram outcome. PMID:26491371

  10. Evaluation of 90-day Repeated Dose Oral Toxicity, Glycometabolism, Learning and Memory Ability, and Related Enzyme of Chromium Malate Supplementation in Sprague-Dawley Rats.

    PubMed

    Feng, Weiwei; Wu, Huiyu; Li, Qian; Zhou, Zhaoxiang; Chen, Yao; Zhao, Ting; Feng, Yun; Mao, Guanghua; Li, Fang; Yang, Liuqing; Wu, Xiangyang

    2015-11-01

    Our previous study showed that chromium malate improved the regulation of blood glucose in mice with alloxan-induced diabetes. The present study was designed to evaluate the 90-day oral toxicity of chromium malate in Sprague-Dawley rats. The present study inspected the effect of chromium malate on glycometabolism, glycometabolism-related enzymes, lipid metabolism, and learning and memory ability in metabolically healthy Sprague-Dawley rats. The results showed that all rats survived and pathological, toxic, feces, and urine changes were not observed. Chromium malate did not cause measurable damage on liver, brain, and kidney. The fasting blood glucose, serum insulin, insulin resistance index, C-peptide, hepatic glycogen, glucose-6-phosphate dehydrogenase, glucokinase, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglyceride levels of normal rats in chromium malate groups had no significant change when compared with control group and chromium picolinate group under physiologically relevant conditions. The serum and organ content of Cr in chromium malate groups had no significant change compared with control group. No significant changes were found in morris water maze test and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and true choline esterase (TChE) activity. The results indicated that supplementation with chromium malate did not cause measurable toxicity and has no obvious effect on glycometabolism and related enzymes, learning and memory ability, and related enzymes and lipid metabolism of female and male rats. The results of this study suggest that chromium malate is safe for human consumption.

  11. Compositional and toxicological analysis of a GM potato line with reduced α-solanine content--a 90-day feeding study in the Syrian Golden hamster.

    PubMed

    Langkilde, Søren; Schrøder, Malene; Frank, Thomas; Shepherd, Louise V T; Conner, Sean; Davies, Howard V; Meyer, Otto; Danier, Jürgen; Rychlik, Michael; Belknap, William R; McCue, Kent F; Engel, Karl-Heinz; Stewart, Derek; Knudsen, Ib; Poulsen, Morten

    2012-10-01

    Steroidal glycoalkaloids (GAs) are toxins, produced by plants of the Solanaceae family. The potato plant (Solanum tuberosum L.) and its tubers predominantly contain the two GAs α-chaconine and α-solanine. These compounds are believed to act in synergy, and the degree of toxicity may therefore depend on their ratio in the potato. To determine the influence of α-solanine: α-chaconine ratio in potatoes on toxicity, a GM potato line (SGT 9-2) with reduced α-solanine content, and the parental control line (Desirée wild-type) having a traditional α-solanine: α-chaconine ratio were (1) studied for compositional similarity by analysing for a range of potato constituents, and (2) used in a 90-day feeding trial with the Syrian Golden hamster to study differential toxicity. The animal feeding study used diets with up to 60% freeze-dried potato powder from either line. Whilst data indicated some compositional differences between the GM line and its wildtype control these did not raise concerns related to nutritional value or safety. Results of the feeding trials showed a low number of significant differences between potato lines with different α-solanine: α-chaconine ratio but none were considered to raise safety concerns with regard to human (or animal) consumption.

  12. A 90 day safety assessment of genetically modified rice expressing Cry1Ab/1Ac protein using an aquatic animal model.

    PubMed

    Zhu, Hao-Jun; Chen, Yi; Li, Yun-He; Wang, Jia-Mei; Ding, Jia-Tong; Chen, Xiu-Ping; Peng, Yu-Fa

    2015-04-15

    In fields of transgenic Bt rice, frogs are exposed to Bt proteins through consumption of both target and nontarget insects. In the present study, we assessed the risk posed by transgenic rice expressing a Cry1Ab/1Ac fusion protein (Huahui 1, HH1) on the development of Xenopus laevis. For 90 days, froglets were fed a diet with 30% HH1 rice, 30% parental rice (Minghui 63, MH63), or no rice as a control. Body weight and length were measured every 15 days. After sacrificing the froglets, we performed a range of biological, clinical, and pathological assessments. No significant differences were found in body weight (on day 90: 27.7 ± 2.17, 27.4 ± 2.40, and 27.9 ± 1.67 g for HH1, MH63, and control, respectively), body length (on day 90: 60.2 ± 1.55, 59.3 ± 2.33, and 59.7 ± 1.64 mm for HH1, MH63, and control, respectively), animal behavior, organ weight, liver and kidney function, or the microstructure of some tissues between the froglets fed on the HH1-containing diet and those fed on the MH63-containing or control diets. This indicates that frog development was not adversely affected by dietary intake of Cry1Ab/1Ac protein.

  13. A 90-day repeated dose oral (gavage) toxicity study of perfluorohexanoic acid (PFHxA) in rats (with functional observational battery and motor activity determinations).

    PubMed

    Chengelis, Christopher P; Kirkpatrick, Jeannie B; Radovsky, Ann; Shinohara, Motoki

    2009-06-01

    Possible toxic effects of perfluorohexanoic acid (PFHxA) were evaluated when administered orally by gavage to rats at levels up to 200mg/kg/day for 90 days. Lower body weight gains were noted in the 10, 50 and 200mg/kg/day group males (not dose-responsive) throughout dosing. Other changes included lower red blood cell parameters, higher reticulocyte counts and lower globulin in the 200mg/kg/day group males and females, higher liver enzymes in males at 50 and 200mg/kg/day, lower total protein and higher albumin/globulin ratio, and lower cholesterol, calcium in males at 200mg/kg/day. Minimal centrilobular hepatocellular hypertrophy was present in 200mg/kg/day group males and correlated with higher liver weights and slightly higher peroxisome beta oxidation activity at the end of the dosing period. Based on liver histopathology and liver weight changes, the no-observed-adverse-effect level (NOAEL) for oral administration was 50mg/kg/day for males and 200mg/kg/day for females.

  14. Metabonomics study of transgenic Bacillus thuringiensis rice (T2A-1) meal in a 90-day dietary toxicity study in rats.

    PubMed

    Cao, Sishuo; Xu, Wentao; Luo, YunBo; He, Xiaoyun; Yuan, Yanfang; Ran, Wenjun; Liang, Lixing; Huang, Kunlun

    2011-07-01

    Rice is one of the most important staple foods in the world. The Cry2A gene was inserted into the rice genome to help the plant combat insects. As the unintended effects of the genetically modified (GM) organisms are the most important barriers to the promotion of GM organisms, we have carried out a useful exploration to establish a new in vivo evaluation model for genetically modified foods by metabonomics methods. In this study, the rats were fed for 90 days with the GM and NON-GM rice diets. The changes in metabolites of the urine were detected using (1)H-NMR. The metabonomics were analyzed to see whether the GM rice can induce the metabolite changes in the rats' urine when compared with the NON-GM rice group. The multivariate analysis and ANOVA were used to determine the differences and the significance of differences respectively, and eventually we concluded that these differences did not have a biological significance. The conclusion of the metabonomics was comparable with that from the traditional method. As a non-invasive and dynamic monitoring method, metabonomics will be a new way of assessing the food safety of GM foods.

  15. Modifications of azoxymethane-induced carcinogenesis and 90-day oral toxicities of 2-tetradecylcyclobutanone as a radiolytic product of stearic acid in F344 rats

    PubMed Central

    Sato, Makoto; Todoriki, Setsuko; Takahashi, Tetsuyuki; Hafez, Ezar; Takasu, Chie; Uehara, Hisanori; Yamakage, Kohji; Kondo, Takashi; Matsumoto, Kozo; Furuta, Masakazu; Izumi, Keisuke

    2015-01-01

    A 90-day oral toxicity test in rats was performed to evaluate the toxicity of 2-tetradecylcyclobutanone (2-tDCB), a unique radiolytic product of stearic acid. Six-week-old male and female F344 rats (n=15/group) were given 2-tDCB at concentrations of 0, 12, 60 and 300 ppm in a powder diet for 13 weeks. Slight dose-dependent increases in serum total protein and albumin in male rats were found, but these changes were not considered to be a toxic effect. The fasting, but not non-fasting, blood glucose levels of the male rats in the 300 ppm group and female rats in the 60 and 300 ppm groups were lower than those of the controls. Gas chromatography-mass spectrometry analysis showed dose-dependent accumulation of 2-tDCB in adipose tissue, notably in males. Next, we performed an azoxymethane (AOM)-induced two-stage carcinogenesis study. After injection of 6-week-old male F344 rats (n=30/group) once a week for 3 weeks, the animals received 2-tDCB at concentrations of 0, 10, 50 and 250 ppm in a powder diet for 25 weeks. The incidences of colon tumors for the 2-tDCB dosages were 34%, 45%, 40% and 37%, respectively, and were not statistically significant. These data suggest that 2-tDCB shows no toxic or tumor-modifying effects under the present conditions, and that the no-observed-adverse-effect level for 2-tDCB is 300 ppm in both sexes, equivalent to 15.5 mg/kg b.w./day in males and 16.5 mg/kg b.w./day in females. PMID:26028819

  16. The mean age of petit mal epilepsy

    PubMed Central

    Syeda, Afsarunnesa; Karim, Md. Rezaul

    2016-01-01

    Objective: Petit mal epilepsy or absence seizures involve brief, sudden lapses of consciousness and most often occurs in people under age of 20 years. This study was done to find out the most likely significant age affected by petit mal epilepsy and whether they had higher rate of behavioral, educational, and social problems. Materials and Methods: We run tests on total 32 patients (male 16 and female 16) from newborns to 20 years of age. Results: The most affected ages were from 4 to 9 years and both genders were equally affected. They have higher rate of behavioral, educational, and social problems, and most likely recovering ages from the disease were from 15 to 20 years. Conclusion: These findings could contribute in diagnosis and treatment of Petit Mal Epilepsy, as it often misinterpreted as daydreaming or inattention.

  17. [Spontaneous bilateral Petit hernia].

    PubMed

    Fontoura, Rodrigo Dias; Araújo, Emerson Silveira de; Oliveira, Gustavo Alves de; Sarmenghi Filho, Deolindo; Kalil, Mitre

    2011-01-01

    Petit's lumbar hernia is an uncommon defect of the posterior abdominal wall that represents less than 1% of all abdominal wall hernias. It is more often unilateral and founded in young females, rarely containing a real herniated sac. There are two different approaches to repair: laparoscopy and open surgery. The goal of this article is to report one case of spontaneous bilateral lumbar Petit's hernia treated with open surgery.

  18. 78 FR 31579 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Petition...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-24

    ... published in the Federal Register on November 27, 2012 (77 FR 70828). This information collection is subject...; Petition for Finding Under Employee Retirement Income Security Act ACTION: Notice. SUMMARY: The Department... information collection request (ICR) titled, ``Petition for Finding under Employee Retirement Income...

  19. Physico-chemical properties of a novel (-)-hydroxycitric acid extract and its effect on body weight, selected organ weights, hepatic lipid peroxidation and DNA fragmentation, hematology and clinical chemistry, and histopathological changes over a period of 90 days.

    PubMed

    Shara, Michael; Ohia, Sunny E; Schmidt, Robert E; Yasmin, Taharat; Zardetto-Smith, Andrea; Kincaid, Anthony; Bagchi, Manashi; Chatterjee, Archana; Bagchi, Debasis; Stohs, Sidney J

    2004-05-01

    Garcinia cambogia-derived (-)-hydroxycitric acid (HCA) is a popular and natural supplement for weight management. HCA is a competitive inhibitor of the enzyme ATP citrate lyase, which catalyzes the conversion of citrate and coenzyme A to oxaloacetate and acetyl coenzyme A (acetyl CoA) in the cytosol. Acetyl CoA is used in the synthesis of fatty acids, cholesterol and triglycerides, and in the synthesis of acetylcholine in the central nervous system. Studies have demonstrated the efficacy of a novel 60% calcium-potassium salt of HCA derived from Garcinia cambogia (HCA-SX, Super CitriMax) in weight management. Results have shown that HCA-SX promotes fat oxidation, enhances serotonin release and availability in the brain cortex, normalizes lipid profiles, and lowers serum leptin levels in obese subjects. Acute oral, acute dermal, primary dermal irritation and primary eye irritation toxicity, as well as Ames bacterial reverse mutation studies and mouse lymphoma tests have demonstrated the safety of HCA-SX. However, no detailed long-term safety of HCA-SX or any other HCA extract has been previously assessed. We evaluated the dose- and time-dependent effects of HCA-SX in Sprague-Dawley rats on body weight, selected organ weights, hepatic lipid peroxidation and DNA fragmentation, hematology and clinical chemistry over a period of 90 days. Furthermore, a 90-day histopathological evaluation was conducted. The animals were treated with 0, 0.2, 2.0 and 5.0% HCA-SX of feed intake and were sacrificed on 30, 60 or 90 days of treatment. The body weight and selected organ weights were assessed and correlated as a % of body weight and brain weight at 90 days of treatment. A significant reduction in body weight was observed in treated rats as compared to control animals. An advancing age-induced marginal increase in hepatic lipid peroxidation was observed in both male and female rats, while no such difference in hepatic DNA fragmentation was observed as compared to the control

  20. Peste des petits ruminants in Arabian wildlife.

    PubMed

    Kinne, J; Kreutzer, R; Kreutzer, M; Wernery, U; Wohlsein, P

    2010-08-01

    Recurrence of peste des petits ruminants (PPR) was diagnosed in the United Arabian Emirates in several wild ruminants confirmed by morphological, immunohistochemical, serological and molecular findings. Phylogenetic analysis revealed that the virus strain belongs to lineage IV, which is different to some previously isolated PPR strains from the Arabian Peninsula. This study shows that wild ruminants may play an important epidemiological role as virus source for domestic small ruminants.

  1. 78 FR 43093 - Richard C. Theuer; Filing of Food Additive Petition and Citizen Petition

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-19

    ... Additive Petition and Citizen Petition AGENCY: Food and Drug Administration, HHS. ACTION: Notice of...., has filed a petition proposing that the food additive regulations be amended to prohibit the use of... a food additive petition (FAP 3A4798; Docket No. FDA-2013-F-0700). The petition proposes to...

  2. Assessment of the safety of hydrogenated resistant maltodextrin: reverse mutation assay, acute and 90-day subchronic repeated oral toxicity in rats, and acute no-effect level for diarrhea in humans.

    PubMed

    Yoshikawa, Yuko; Kishimoto, Yuka; Tagami, Hiroyuki; Kanahori, Sumiko

    2013-01-01

    A series of safety assessments were performed on hydrogenated resistant maltodextrin prepared by converting the reducing terminal glucose of resistant maltodextrin into sorbitol. The reverse mutation assay did not show mutagenicity. Acute and 90-day subchronic oral toxicity studies in rats showed no death was observed in any groups, including the group receiving the highest single dose of 10 g/kg body weight or the highest dose of 5 g/kg body weight per day for 90 days. Mucous or watery stools were observed in the hydrogenated resistant maltodextrin treatment group on the acute study, which were transient and were associated with the osmotic pressure caused by intake of the high concentrations. Subchronic study showed dose-dependent increases in the weights of cecum alone, cecal contents alone, and cecum with cecal contents as well as hypertrophy of the cecal mucosal epithelium, which are considered to be common physiological responses after intake of indigestible carbohydrates. These results indicated that the no observed adverse effect level (NOAEL) of hydrogenated resistant maltodextrin was 10 g/kg body weight or more on the acute oral toxicity study and 5.0 g/kg body weight/day or more on the 90-day subchronic repeated oral toxicity study in rats. Further study performed in healthy adult humans showed that the acute no-effect level of hydrogenated resistant maltodextrin for diarrhea was 0.8 g/kg body weight for men and more than 1.0 g/kg body weight for women. The results of the current safety assessment studies suggest that hydrogenated resistant maltodextrin is safe for human consumption.

  3. 40 CFR 82.184 - Petitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... person may petition the Agency to amend existing listing decisions under the SNAP program, or to add a new substance to any of the SNAP lists. (b) Types of petitions. Five types of petitions exist: (1) Petitions to add a substitute not previously reviewed under the SNAP program to the acceptable list....

  4. 40 CFR 82.184 - Petitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... person may petition the Agency to amend existing listing decisions under the SNAP program, or to add a new substance to any of the SNAP lists. (b) Types of petitions. Five types of petitions exist: (1) Petitions to add a substitute not previously reviewed under the SNAP program to the acceptable list....

  5. 40 CFR 82.184 - Petitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... person may petition the Agency to amend existing listing decisions under the SNAP program, or to add a new substance to any of the SNAP lists. (b) Types of petitions. Five types of petitions exist: (1) Petitions to add a substitute not previously reviewed under the SNAP program to the acceptable list....

  6. 40 CFR 82.184 - Petitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... person may petition the Agency to amend existing listing decisions under the SNAP program, or to add a new substance to any of the SNAP lists. (b) Types of petitions. Five types of petitions exist: (1) Petitions to add a substitute not previously reviewed under the SNAP program to the acceptable list....

  7. 40 CFR 82.184 - Petitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... person may petition the Agency to amend existing listing decisions under the SNAP program, or to add a new substance to any of the SNAP lists. (b) Types of petitions. Five types of petitions exist: (1) Petitions to add a substitute not previously reviewed under the SNAP program to the acceptable list....

  8. 21 CFR 571.1 - Petitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... establishing that the food additive will have the intended physical or other technical effect or that it may... RELATED PRODUCTS FOOD ADDITIVE PETITIONS General Provisions § 571.1 Petitions. (a) Petitions to be filed... support of a food-additive petition should be accompanied by reprints or photostatic copies of...

  9. 21 CFR 171.1 - Petitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... CONSUMPTION (CONTINUED) FOOD ADDITIVE PETITIONS General Provisions § 171.1 Petitions. (a) Petitions to be... published information offered in support of a food additive petition should be accompanied by reprints or... following form: (Date) Name of petitioner Post-office address Date Name of food additive and proposed...

  10. 21 CFR 171.1 - Petitions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... CONSUMPTION (CONTINUED) FOOD ADDITIVE PETITIONS General Provisions § 171.1 Petitions. (a) Petitions to be... published information offered in support of a food additive petition should be accompanied by reprints or... following form: (Date) Name of petitioner Post-office address Date Name of food additive and proposed...

  11. 21 CFR 171.1 - Petitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... CONSUMPTION (CONTINUED) FOOD ADDITIVE PETITIONS General Provisions § 171.1 Petitions. (a) Petitions to be... published information offered in support of a food additive petition should be accompanied by reprints or... following form: (Date) Name of petitioner Post-office address Date Name of food additive and proposed...

  12. 16 CFR 1051.10 - Granting petitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Granting petitions. 1051.10 Section 1051.10... § 1051.10 Granting petitions. (a) The Commission shall either grant or deny a petition within a.... The Commission may also grant a petition in part or deny it in part. If the Commission grants...

  13. Using Petitions To Teach Slavery.

    ERIC Educational Resources Information Center

    Freeman, Damon

    2003-01-01

    Presents a lesson for teaching students about slavery in the United States by using slavery petitions. Describes a lesson that spans over two class periods, explaining that on the first day students listen to an interview with Professor Loren Schweninger about the "Talking History" program. Includes reproductions of the petitions. (CMK)

  14. Comparison of growth, serum biochemistries and n-6 fatty acid metabolism in rats fed diets supplemented with high-gamma-linolenic acid safflower oil or borage oil for 90 days.

    PubMed

    Tso, Patrick; Caldwell, Jody; Lee, Dana; Boivin, Gregory P; DeMichele, Stephen J

    2012-06-01

    Recently, steps have been taken to further developments toward increasing gamma-linolenic acid (GLA) concentration and lowering costs in plant seed oils using transgenic technology. Through identification and expression of a fungal delta-6 desaturase gene in the high linoleic acid safflower plant, the seeds from this genetic transformation produce oil with >40% GLA (high GLA safflower oil (HGSO)). The aim of the study was to compare the effects of feeding HGSO to a generally recognized as safe source of GLA, borage oil, in a 90 day safety study in rats. Weanling male and female Sprague-Dawley rats were fed a semi-synthetic, fat free, pelleted diet (AIN93G) supplemented with a 10% (wt/wt) oil blend containing HGSO or borage oil, with equivalent GLA levels. Results demonstrated that feeding diets containing HGSO or borage oil for 90 days had similar biologic effects with regard to growth characteristics, body composition, behavior, organ weight and histology, and parameters of hematology and serum biochemistries in both sexes. Metabolism of the primary n-6 fatty acids in plasma and organ phospholipids was similar, despite minor changes in females. We conclude that HGSO is biologically equivalent to borage oil and provides a safe alternative source of GLA in the diet. PMID:22265940

  15. Comparison of growth, serum biochemistries and n-6 fatty acid metabolism in rats fed diets supplemented with high-gamma-linolenic acid safflower oil or borage oil for 90 days.

    PubMed

    Tso, Patrick; Caldwell, Jody; Lee, Dana; Boivin, Gregory P; DeMichele, Stephen J

    2012-06-01

    Recently, steps have been taken to further developments toward increasing gamma-linolenic acid (GLA) concentration and lowering costs in plant seed oils using transgenic technology. Through identification and expression of a fungal delta-6 desaturase gene in the high linoleic acid safflower plant, the seeds from this genetic transformation produce oil with >40% GLA (high GLA safflower oil (HGSO)). The aim of the study was to compare the effects of feeding HGSO to a generally recognized as safe source of GLA, borage oil, in a 90 day safety study in rats. Weanling male and female Sprague-Dawley rats were fed a semi-synthetic, fat free, pelleted diet (AIN93G) supplemented with a 10% (wt/wt) oil blend containing HGSO or borage oil, with equivalent GLA levels. Results demonstrated that feeding diets containing HGSO or borage oil for 90 days had similar biologic effects with regard to growth characteristics, body composition, behavior, organ weight and histology, and parameters of hematology and serum biochemistries in both sexes. Metabolism of the primary n-6 fatty acids in plasma and organ phospholipids was similar, despite minor changes in females. We conclude that HGSO is biologically equivalent to borage oil and provides a safe alternative source of GLA in the diet.

  16. A successful petition to delist a hazardous waste

    SciTech Connect

    Finch, A.J.; Cormier, S.L.

    1997-12-31

    The prospect of a favorable ruling in an effort to have a hazardous waste delisted is remote, and few have been granted. This paper recounts the successful procedure used to have materials from a hazardous waste site delisted. Other property owners with sites affected with hazardous wastes will find the methodology discussed here instructive if they are contemplating a delisting petition. The regulatory agency with jurisdiction was the Michigan Department of Environmental Quality through its Waste Management Division (MDEQ WMD). The state has accepted authority for this function from the USEPA. The materials from discontinued electroplating operations were considered hazardous based on their contact with a listed F006 waste sludge generated from the electroplating operations. The sludge had been stored in surface impoundments. To initiate the delisting procedure, the requirements of a USEPA document were followed: Petition to Delist Hazardous Wastes, a Guidance Manual. The MDEQ WMD sanctioned the use of this guidance. This document is issued by the Office of Solid Waste. In observing the guidance, the following actions were taken: (1) Collection of soil samples from the area proposed for delisting; (2) Evaluation of data and the feasibility of preparing a delisting petition; (3) Development of the petition. In developing the details of the petition, the data from the site were scrutinized. Analytical results of metals in the soil samples were compared with pre-established maximum allowable concentrations that had been calculated in a closure plan. These values were also compared with delisting levels calculated by USEPA`s Composite Model for Landfills (EPACML). The data indicated that the levels of chemical constituents were below the appropriate regulatory criteria. Therefore, the petition was launched. This paper discusses their effective procedure and contents of each section of the delisting petition.

  17. Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90 days of exposure to hexavalent chromium in drinking water

    SciTech Connect

    Kopec, Anna K.; Kim, Suntae; Forgacs, Agnes L.; Zacharewski, Timothy R.; Proctor, Deborah M.; Harris, Mark A.; Haws, Laurie C.; Thompson, Chad M.

    2012-02-15

    Chronic administration of high doses of hexavalent chromium [Cr(VI)] as sodium dichromate dihydrate (SDD) elicits alimentary cancers in mice. To further elucidate key events underlying tumor formation, a 90-day drinking water study was conducted in B6C3F1 mice. Differential gene expression was examined in duodenal and jejunal epithelial samples following 7 or 90 days of exposure to 0, 0.3, 4, 14, 60, 170 or 520 mg/L SDD in drinking water. Genome-wide microarray analyses identified 6562 duodenal and 4448 jejunal unique differentially expressed genes at day 8, and 4630 and 4845 unique changes, respectively, in the duodenum and jejunum at day 91. Comparative analysis identified significant overlap in duodenal and jejunal differential gene expression. Automated dose–response modeling identified > 80% of the differentially expressed genes exhibited sigmoidal dose–response curves with EC{sub 50} values ranging from 10 to 100 mg/L SDD. Only 16 genes satisfying the dose-dependent differential expression criteria had EC{sub 50} values < 10 mg/L SDD, 3 of which were regulated by Nrf2, suggesting oxidative stress in response to SDD at low concentrations. Analyses of differentially expressed genes identified over-represented functions associated with oxidative stress, cell cycle, lipid metabolism, and immune responses consistent with the reported effects on redox status and histopathology at corresponding SDD drinking water concentrations. Collectively, these data are consistent with a mode of action involving oxidative stress and cytotoxicity as early key events. This suggests that the tumorigenic effects of chronic Cr(VI) oral exposure likely require chronic tissue damage and compensatory epithelial cell proliferation. Highlights: ► Mouse small intestine gene expression is highly responsive to hexavalent chromium [Cr(VI)]. ► Cr(VI) elicits more differential gene expression after 7 days of exposure than 90 days of exposure. ► Oral exposure to Cr(VI) leads to

  18. 78 FR 13745 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-28

    ... (65 FR 19477-78). Docket: To read background documents or comments received, go to http://www... February 19, 2013. Lirio Liu, Director, Office of Rulemaking. Petition for Exemption Docket No.:...

  19. 78 FR 46672 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-01

    ... Register published on April 11, 2000 (65 FR 19477-78). Docket: To read background documents or comments... published pursuant to 14 CFR 11.85. Lirio Liu, Director, Office of Rulemaking. Petition for Exemption...

  20. 77 FR 65764 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-30

    ... Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477-78). Docket: To.... Issued in Washington, DC, on October 23, 2012. Lirio Liu, Director, Office of Rulemaking. Petition...

  1. 78 FR 46673 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-01

    ... Register published on April 11, 2000 (65 FR 19477-78). Docket: To read background documents or comments..., DC, on June 26, 2013. Lirio Liu, Director, Office of Rulemaking. Petition for Exemption Docket...

  2. 77 FR 72432 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-05

    ... (65 FR 19477-78). Docket: To read background documents or comments received, go to http://www... November 30, 2012. Lirio Liu, Acting Director, Office of Rulemaking. Petition for Exemption Docket No.:...

  3. 77 FR 65762 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-30

    ... Register published on April 11, 2000 (65 FR 19477-78). Docket: To read background documents or comments... Washington, DC, on October 23, 2012. Lirio Liu, Director, Office of Rulemaking. Petition for Exemption...

  4. 78 FR 73918 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-09

    ... in the Federal Register published on April 11, 2000 (65 FR 19477-78). Docket: To read background... December 13, 2013. Lirio Liu, Director, Office of Rulemaking. Petition for Exemption Docket No.:...

  5. 77 FR 71864 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-04

    ... (65 FR 19477-78). Docket: To read background documents or comments received, go to http://www.... Issued in Washington, DC, on November 29, 2012. Lirio Liu, Director, Office of Rulemaking. Petition...

  6. Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90days of exposure to hexavalent chromium in drinking water.

    PubMed

    Kopec, Anna K; Kim, Suntae; Forgacs, Agnes L; Zacharewski, Timothy R; Proctor, Deborah M; Harris, Mark A; Haws, Laurie C; Thompson, Chad M

    2012-02-15

    Chronic administration of high doses of hexavalent chromium [Cr(VI)] as sodium dichromate dihydrate (SDD) elicits alimentary cancers in mice. To further elucidate key events underlying tumor formation, a 90-day drinking water study was conducted in B6C3F1 mice. Differential gene expression was examined in duodenal and jejunal epithelial samples following 7 or 90days of exposure to 0, 0.3, 4, 14, 60, 170 or 520mg/L SDD in drinking water. Genome-wide microarray analyses identified 6562 duodenal and 4448 jejunal unique differentially expressed genes at day 8, and 4630 and 4845 unique changes, respectively, in the duodenum and jejunum at day 91. Comparative analysis identified significant overlap in duodenal and jejunal differential gene expression. Automated dose-response modeling identified >80% of the differentially expressed genes exhibited sigmoidal dose-response curves with EC(50) values ranging from 10 to 100mg/L SDD. Only 16 genes satisfying the dose-dependent differential expression criteria had EC(50) values <10mg/L SDD, 3 of which were regulated by Nrf2, suggesting oxidative stress in response to SDD at low concentrations. Analyses of differentially expressed genes identified over-represented functions associated with oxidative stress, cell cycle, lipid metabolism, and immune responses consistent with the reported effects on redox status and histopathology at corresponding SDD drinking water concentrations. Collectively, these data are consistent with a mode of action involving oxidative stress and cytotoxicity as early key events. This suggests that the tumorigenic effects of chronic Cr(VI) oral exposure likely require chronic tissue damage and compensatory epithelial cell proliferation.

  7. 76 FR 61473 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-04

    ...This notice contains a summary of a petition seeking relief from specified requirements of 14 CFR. The purpose of this notice is to improve the public's awareness of, and participation in, this aspect of FAA's regulatory activities. Neither publication of this notice nor the inclusion or omission of information in the summary is intended to affect the legal status of the petition or its final......

  8. 28 CFR 1.1 - Submission of petition; form to be used; contents of petition.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Submission of petition; form to be used; contents of petition. 1.1 Section 1.1 Judicial Administration DEPARTMENT OF JUSTICE EXECUTIVE CLEMENCY § 1.1 Submission of petition; form to be used; contents of petition. A person seeking executive...

  9. 28 CFR 1.1 - Submission of petition; form to be used; contents of petition.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Submission of petition; form to be used; contents of petition. 1.1 Section 1.1 Judicial Administration DEPARTMENT OF JUSTICE EXECUTIVE CLEMENCY § 1.1 Submission of petition; form to be used; contents of petition. A person seeking executive...

  10. 28 CFR 1.1 - Submission of petition; form to be used; contents of petition.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Submission of petition; form to be used; contents of petition. 1.1 Section 1.1 Judicial Administration DEPARTMENT OF JUSTICE EXECUTIVE CLEMENCY § 1.1 Submission of petition; form to be used; contents of petition. A person seeking executive...

  11. 28 CFR 1.1 - Submission of petition; form to be used; contents of petition.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Submission of petition; form to be used; contents of petition. 1.1 Section 1.1 Judicial Administration DEPARTMENT OF JUSTICE EXECUTIVE CLEMENCY § 1.1 Submission of petition; form to be used; contents of petition. A person seeking executive...

  12. 22 CFR 1422.2 - Contents of petition; filing and service of petition; challenges to petition.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... the Criminal Code (18 U.S.C. 1001), that its contents are true and correct to the best of such person... collateral attack at a unit or representation hearing. If the petition is dismissed or the...

  13. 37 CFR 41.3 - Petitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... PRACTICE BEFORE THE PATENT TRIAL AND APPEAL BOARD General Provisions § 41.3 Petitions. (a) Deciding... decision. The Chief Administrative Patent Judge may delegate authority to decide petitions. (b) Scope....

  14. 37 CFR 41.3 - Petitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PRACTICE BEFORE THE PATENT TRIAL AND APPEAL BOARD General Provisions § 41.3 Petitions. (a) Deciding... decision. The Chief Administrative Patent Judge may delegate authority to decide petitions. (b) Scope....

  15. 36 CFR 294.12 - State petitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... to promulgate regulations establishing management requirements for all or any portion of National... State Petitions for Inventoried Roadless Area Management § 294.12 State petitions. The Governor of...

  16. 10 CFR 501.62 - Petition contents.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Petition contents. 501.62 Section 501.62 Energy DEPARTMENT... Certifications § 501.62 Petition contents. (a) A petition for exemption should include the following information... the person who can supply further information. (b) Table of contents. Include only those...

  17. 7 CFR 1.28 - Petitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Petitions. 1.28 Section 1.28 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Departmental Proceedings § 1.28 Petitions. Petitions by interested persons in accordance with 5 U.S.C. 553(e) for the issuance, amendment or repeal of a rule may...

  18. 16 CFR 1702.18 - Denying petitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Denying petitions. 1702.18 Section 1702.18 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION PROCEDURES...

  19. 16 CFR 1702.18 - Denying petitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Denying petitions. 1702.18 Section 1702.18 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION PROCEDURES...

  20. 16 CFR 1702.18 - Denying petitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Denying petitions. 1702.18 Section 1702.18 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION PROCEDURES...

  1. 16 CFR 1702.17 - Granting petitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Granting petitions. 1702.17 Section 1702.17 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION PROCEDURES...

  2. 16 CFR 1702.17 - Granting petitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Granting petitions. 1702.17 Section 1702.17 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION PROCEDURES...

  3. 16 CFR 1702.17 - Granting petitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Granting petitions. 1702.17 Section 1702.17 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION PROCEDURES...

  4. 16 CFR 1702.17 - Granting petitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Granting petitions. 1702.17 Section 1702.17 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION PROCEDURES...

  5. 16 CFR 1702.18 - Denying petitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Denying petitions. 1702.18 Section 1702.18 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION PROCEDURES...

  6. 16 CFR 1702.18 - Denying petitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Denying petitions. 1702.18 Section 1702.18 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION PROCEDURES...

  7. 7 CFR 1.28 - Petitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Petitions. 1.28 Section 1.28 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Departmental Proceedings § 1.28 Petitions. Petitions by interested persons in accordance with 5 U.S.C. 553(e) for the issuance, amendment or repeal of a rule may...

  8. 10 CFR 501.62 - Petition contents.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Petition contents. 501.62 Section 501.62 Energy DEPARTMENT... Certifications § 501.62 Petition contents. (a) A petition for exemption should include the following information... the person who can supply further information. (b) Table of contents. Include only those...

  9. 36 CFR 294.13 - Petition process.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Petition process. 294.13 Section 294.13 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SPECIAL AREAS State Petitions for Inventoried Roadless Area Management § 294.13 Petition process. (a) Review...

  10. 36 CFR 294.13 - Petition process.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 2 2012-07-01 2012-07-01 false Petition process. 294.13 Section 294.13 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SPECIAL AREAS State Petitions for Inventoried Roadless Area Management § 294.13 Petition process. (a) Review...

  11. 36 CFR 294.13 - Petition process.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 2 2013-07-01 2013-07-01 false Petition process. 294.13 Section 294.13 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SPECIAL AREAS State Petitions for Inventoried Roadless Area Management § 294.13 Petition process. (a) Review...

  12. 29 CFR 90.11 - Petitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... address(es) of the person(s) by whom the petition is filed. Every petition shall be signed by at least... 20210. Every petition shall include: (1) The name(s), address(es), and telephone number(s) of...

  13. IS IT THE EXCEPTION OR THE RULE? DAILY CO-OCCURRENCE OF PHYSICAL, SEXUAL, AND PSYCHOLOGICAL PARTNER VIOLENCE IN A 90-DAY STUDY OF SUBSTANCE-USING, COMMUNITY WOMEN

    PubMed Central

    Sullivan, Tami P.; McPartland, Tara; Armeli, Stephen; Jaquier, Véronique; Tennen, Howard

    2013-01-01

    Objective This study aims to describe the daily co-occurrence of physical, sexual, and psychological intimate partner violence (IPV) among substance-using, community-based women currently experiencing IPV. Methods A micro-longitudinal study design was used to collect data daily from 49 women for 90 days. Results On the majority of days (62%), no IPV occurred; 27% of days were characterized by psychological IPV alone, followed by the co-occurrence of psychological and physical IPV (6% of IPV days). Results of person-level analyses showed comparable sized correlations between the proportion of days with physical and sexual IPV and the proportion of days with physical and psychological IPV. However, results of day-level analyses revealed that the association between physical and psychological IPV was much stronger than the association between physical and sexual IPV; Physical IPV was 64 times more likely to occur on days when psychological IPV occurred. Conclusions Results revealed new information about physical, sexual, and psychological IPV experiences and demonstrate the utility of a micro-longitudinal design among this high risk population. Implications for practice, future research, and the development of preventive interventions are noted, underscoring the importance of psychological IPV and the range of IPV experiences among women. PMID:24349863

  14. 29 CFR 1614.304 - Contents of petition.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Contents of petition. 1614.304 Section 1614.304 Labor... EMPLOYMENT OPPORTUNITY Related Processes § 1614.304 Contents of petition. (a) Form. Petitions must be written... EEOC Form 573, Notice Of Appeal/Petition. (b) Contents. Petitions must contain the following: (1)...

  15. 29 CFR 1614.304 - Contents of petition.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 4 2011-07-01 2011-07-01 false Contents of petition. 1614.304 Section 1614.304 Labor... EMPLOYMENT OPPORTUNITY Related Processes § 1614.304 Contents of petition. (a) Form. Petitions must be written... EEOC Form 573, Notice Of Appeal/Petition. (b) Contents. Petitions must contain the following: (1)...

  16. Peste des petits ruminants.

    PubMed

    Parida, S; Muniraju, M; Mahapatra, M; Muthuchelvan, D; Buczkowski, H; Banyard, A C

    2015-12-14

    Peste des petits ruminants virus causes a highly infectious disease of small ruminants that is endemic across Africa, the Middle East and large regions of Asia. The virus is considered to be a major obstacle to the development of sustainable agriculture across the developing world and has recently been targeted by the World Organisation for Animal Health (OIE) and the Food and Agriculture Organisation (FAO) for eradication with the aim of global elimination of the disease by 2030. Fundamentally, the vaccines required to successfully achieve this goal are currently available, but the availability of novel vaccine preparations to also fulfill the requisite for differentiation between infected and vaccinated animals (DIVA) may reduce the time taken and the financial costs of serological surveillance in the later stages of any eradication campaign. Here, we overview what is currently known about the virus, with reference to its origin, updated global circulation, molecular evolution, diagnostic tools and vaccines currently available to combat the disease. Further, we comment on recent developments in our knowledge of various recombinant vaccines and on the potential for the development of novel multivalent vaccines for small ruminants.

  17. Peste des petits ruminants.

    PubMed

    Parida, S; Muniraju, M; Mahapatra, M; Muthuchelvan, D; Buczkowski, H; Banyard, A C

    2015-12-14

    Peste des petits ruminants virus causes a highly infectious disease of small ruminants that is endemic across Africa, the Middle East and large regions of Asia. The virus is considered to be a major obstacle to the development of sustainable agriculture across the developing world and has recently been targeted by the World Organisation for Animal Health (OIE) and the Food and Agriculture Organisation (FAO) for eradication with the aim of global elimination of the disease by 2030. Fundamentally, the vaccines required to successfully achieve this goal are currently available, but the availability of novel vaccine preparations to also fulfill the requisite for differentiation between infected and vaccinated animals (DIVA) may reduce the time taken and the financial costs of serological surveillance in the later stages of any eradication campaign. Here, we overview what is currently known about the virus, with reference to its origin, updated global circulation, molecular evolution, diagnostic tools and vaccines currently available to combat the disease. Further, we comment on recent developments in our knowledge of various recombinant vaccines and on the potential for the development of novel multivalent vaccines for small ruminants. PMID:26443889

  18. Peste des petits ruminants

    PubMed Central

    Parida, S.; Muniraju, M.; Mahapatra, M.; Muthuchelvan, D.; Buczkowski, H.; Banyard, A.C.

    2015-01-01

    Peste des petits ruminants virus causes a highly infectious disease of small ruminants that is endemic across Africa, the Middle East and large regions of Asia. The virus is considered to be a major obstacle to the development of sustainable agriculture across the developing world and has recently been targeted by the World Organisation for Animal Health (OIE) and the Food and Agriculture Organisation (FAO) for eradication with the aim of global elimination of the disease by 2030. Fundamentally, the vaccines required to successfully achieve this goal are currently available, but the availability of novel vaccine preparations to also fulfill the requisite for differentiation between infected and vaccinated animals (DIVA) may reduce the time taken and the financial costs of serological surveillance in the later stages of any eradication campaign. Here, we overview what is currently known about the virus, with reference to its origin, updated global circulation, molecular evolution, diagnostic tools and vaccines currently available to combat the disease. Further, we comment on recent developments in our knowledge of various recombinant vaccines and on the potential for the development of novel multivalent vaccines for small ruminants. PMID:26443889

  19. 76 FR 81010 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-27

    ... published on April 11, 2000 (65 FR 19477-78). Docket: To read background documents or comments received, go... 17, 2012. ADDRESSES: You may send comments identified by Docket Number FAA-2011- 1044 using any of..., Office of Rulemaking. Petition For Exemption Docket No.: FAA-2011-1044. Petitioner: Sundance...

  20. 75 FR 3278 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-20

    ... (65 FR 19477-78). Docket: To read background documents or comments received, go to http://www..., 2010. ADDRESSES: You may send comments identified by Docket Number FAA-2009- 1058 using any of the.... Pamela Hamilton-Powell, Director, Office of Rulemaking. Petition for Exemption Docket No.:...

  1. 77 FR 36333 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-18

    ... published on April 11, 2000 (65 FR 19477-78). Docket: To read background documents or comments received, go..., Acting Director, Office of Rulemaking. Petition for Exemption Docket No.: FAA-2012-0587 Petitioner: Fern... relief sought would allow Ms. Fern Case to use the aircraft lavatory while the Fasten Seat Belt sign...

  2. 77 FR 65763 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-30

    ... (65 FR 19477-78). Docket: To read background documents or comments received, go to http://www.... ADDRESSES: You may send comments identified by Docket Number FAA-2009- 1077 using any of the following..., Office of Rulemaking. Petition for Exemption Docket No.: FAA-2009-1077. Petitioner: Learjet Inc....

  3. 75 FR 10016 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    ... (65 FR 19477-78). Docket: To read background documents or comments received, go to http://www.... ADDRESSES: You may send comments identified by Docket Number FAA-2009- 1087 using any of the following... Rulemaking. Petition for Exemption Docket No.: FAA-2009-1087. Petitioner: Terrafugia, Inc. Section of 14...

  4. 76 FR 72494 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-23

    ... (65 FR 19477-78). Docket: To read background documents or comments received, go to http://www.... ADDRESSES: You may send comments identified by Docket Number FAA-2011- 1042 using any of the following..., Director, Office of Rulemaking. Petition for Exemption Docket No.: FAA-2011-1042. Petitioner: The...

  5. 75 FR 65396 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-22

    ... published on April 11, 2000 (65 FR 19477-78). Docket: To read background documents or comments received, go... November 1, 2010. ADDRESSES: You may send comments identified by Docket Number FAA-2010- 1057 using any of... Hamilton-Powell, Director, Office of Rulemaking. Petition for Exemption Docket No.:...

  6. 77 FR 4394 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-27

    .... Petition for Exemption Docket No.: FAA-2011-1361. Petitioner: Southwest Airlines Co. Section of 14 CFR Affected: 14 CFR 121.163(a) Description of Relief Sought: Southwest Airlines requests to extend the date by... (65 FR 19477-78). Docket: To read background documents or comments received, go to...

  7. 77 FR 61469 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-09

    ... of Rulemaking. Petition for Exemption Docket No.: FAA-2012-0113. Petitioner: Southwest Airlines... (65 FR 19477-78). Docket: To read background documents or comments received, go to ] http://www... allow Southwest to operate its aircraft without carrying the appropriate parts of the maintenance...

  8. 77 FR 10482 - Trademark Petitions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-22

    ... USPTO error, an applicant may file a request to reinstate the application instead of a formal petition... other for-profit organizations. Estimated Number of Respondents: 2,135 responses per year. Estimated... (Paper) 40 minutes 120 80 Totals 2,135 1,689 Estimated Total Annual (Non-hour) Respondent Cost...

  9. Incarcerated inferior lumbar (Petit's) hernia.

    PubMed

    Astarcioğlu, H; Sökmen, S; Atila, K; Karademir, S

    2003-09-01

    Petit's hernia is an uncommon abdominal wall defect in the inferior lumbar triangle. Colonic incarceration through the inferior lumbar triangle, which causes mechanical obstructive symptoms, necessitates particular diagnostic and management strategy. We present a rare case of inferior lumbar hernia, leading to mechanical bowel obstruction, successfully treated with prosthetic mesh reinforcement repair.

  10. 5 CFR 1201.114 - Filing petition and cross petition for review.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... review. 1201.114 Section 1201.114 Administrative Personnel MERIT SYSTEMS PROTECTION BOARD ORGANIZATION AND PROCEDURES PRACTICES AND PROCEDURES Petitions for Review of Initial Decisions § 1201.114 Filing petition and cross petition for review. (a) Who may file. Any party to the proceeding, the Director of...

  11. [The tourniquet of Jean-Louis Petit].

    PubMed

    Renner, Claude

    2014-01-01

    In the early part of the 18th century the mechanization of Petit's tourniquet is one of the most outstanding medical inventions. During more than a century that tool without any noticeable change was in the surgical boxes in all countries. As the mechanic Peron has been intensely working to handcraft the device with the utmost urgency Petit's tourniquet could have become that of Petit and Peron.

  12. Peste des petits ruminants outbreaks in White Nile State, Sudan.

    PubMed

    Ishag, Osama M; Saeed, Intisar K; Ali, Yahia H

    2015-01-01

    Eight outbreaks of peste des petits ruminants in sheep and goats were reported in White Nile State, Sudan, between 2008 and 2009. A mortality rate of 4.2% was reported across the different outbreaks. Clinically the disease was characterised by high fever, ocular and nasal discharge, pneumonia, ulceration of the mucous membranes, diarrhoea and death. The postmortem findings included necrotic lesions in the mouth and gastrointestinal tract, and swollen, oedematous lymph nodes associated with the lungs and intestine. Of the 209 serum samples tested by competitive enzyme-linked immunosorbent assay, 113 (54%) were found positive. Peste des petits ruminants virus was confirmed in tissues, nasal swabs and blood samples by immunocapture enzyme-linked immunosorbent assay, reverse-transcription polymerase chain reaction and isolation of the virus in culture of lamb testicle cells. PMID:26304168

  13. Peste des petits ruminants outbreaks in White Nile State, Sudan.

    PubMed

    Ishag, Osama M; Saeed, Intisar K; Ali, Yahia H

    2015-08-21

    Eight outbreaks of peste des petits ruminants in sheep and goats were reported in White Nile State, Sudan, between 2008 and 2009. A mortality rate of 4.2% was reported across the different outbreaks. Clinically the disease was characterised by high fever, ocular and nasal discharge, pneumonia, ulceration of the mucous membranes, diarrhoea and death. The postmortem findings included necrotic lesions in the mouth and gastrointestinal tract, and swollen, oedematous lymph nodes associated with the lungs and intestine. Of the 209 serum samples tested by competitive enzyme-linked immunosorbent assay, 113 (54%) were found positive. Peste des petits ruminants virus was confirmed in tissues, nasal swabs and blood samples by immunocapture enzyme-linked immunosorbent assay, reverse-transcription polymerase chain reaction and isolation of the virus in culture of lamb testicle cells.

  14. 46 CFR 550.403 - Contents of petitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 9 2013-10-01 2013-10-01 false Contents of petitions. 550.403 Section 550.403 Shipping FEDERAL MARITIME COMMISSION REGULATIONS AND ACTIONS TO ADDRESS RESTRICTIVE FOREIGN MARITIME PRACTICES... Petitions for Section 19 Relief § 550.403 Contents of petitions. Petitions for relief from...

  15. 8 CFR 204.6 - Petitions for employment creation aliens.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Petitions for employment creation aliens. 204.6 Section 204.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRANT PETITIONS Immigrant Visa Petitions § 204.6 Petitions for employment creation aliens. (a)...

  16. 8 CFR 204.6 - Petitions for employment creation aliens.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Petitions for employment creation aliens. 204.6 Section 204.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRANT PETITIONS Immigrant Visa Petitions § 204.6 Petitions for employment creation aliens. (a)...

  17. 46 CFR 550.403 - Contents of petitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 9 2010-10-01 2010-10-01 false Contents of petitions. 550.403 Section 550.403 Shipping FEDERAL MARITIME COMMISSION REGULATIONS AND ACTIONS TO ADDRESS RESTRICTIVE FOREIGN MARITIME PRACTICES... Petitions for Section 19 Relief § 550.403 Contents of petitions. Petitions for relief from...

  18. 47 CFR 69.707 - Geographic scope of petition.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) ACCESS CHARGES Pricing Flexibility § 69.707 Geographic scope of petition. (a) MSA. (1) A price cap LEC filing a petition for pricing flexibility in an MSA shall include data sufficient to support its petition... flexibility for two or more MSAs in a single petition, provided that it submits supporting data...

  19. 47 CFR 69.707 - Geographic scope of petition.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) ACCESS CHARGES Pricing Flexibility § 69.707 Geographic scope of petition. (a) MSA. (1) A price cap LEC filing a petition for pricing flexibility in an MSA shall include data sufficient to support its petition... flexibility for two or more MSAs in a single petition, provided that it submits supporting data...

  20. 47 CFR 69.707 - Geographic scope of petition.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) ACCESS CHARGES Pricing Flexibility § 69.707 Geographic scope of petition. (a) MSA. (1) A price cap LEC filing a petition for pricing flexibility in an MSA shall include data sufficient to support its petition... flexibility for two or more MSAs in a single petition, provided that it submits supporting data...

  1. 47 CFR 69.707 - Geographic scope of petition.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) ACCESS CHARGES Pricing Flexibility § 69.707 Geographic scope of petition. (a) MSA. (1) A price cap LEC filing a petition for pricing flexibility in an MSA shall include data sufficient to support its petition... flexibility for two or more MSAs in a single petition, provided that it submits supporting data...

  2. 47 CFR 69.707 - Geographic scope of petition.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) ACCESS CHARGES Pricing Flexibility § 69.707 Geographic scope of petition. (a) MSA. (1) A price cap LEC filing a petition for pricing flexibility in an MSA shall include data sufficient to support its petition... flexibility for two or more MSAs in a single petition, provided that it submits supporting data...

  3. 8 CFR 334.16 - Amendment of petition for naturalization.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Amendment of petition for naturalization... APPLICATION FOR NATURALIZATION § 334.16 Amendment of petition for naturalization. (a) During pendency of petition. An application to amend a petition for naturalization, filed prior to October 1, 1991, while...

  4. 8 CFR 334.16 - Amendment of petition for naturalization.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Amendment of petition for naturalization... APPLICATION FOR NATURALIZATION § 334.16 Amendment of petition for naturalization. (a) During pendency of petition. An application to amend a petition for naturalization, filed prior to October 1, 1991, while...

  5. 49 CFR 543.5 - Petition: General requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... § 543.5 Petition: General requirements. (a) For each model year, a manufacturer may petition NHTSA for... manufacturer may not petition NHTSA for an exemption for model years before model year 2006. (b) Each petition... specified under paragraph (5) of § 543.5(b) for the first model year in which the petitioner wishes...

  6. 1869 Petition: The Appeal for Woman Suffrage. Teaching with Documents.

    ERIC Educational Resources Information Center

    Haverkamp, Beth, Ed.; And Others

    1995-01-01

    Maintains that between 1848 and 1920 when the 19th Amendment was ratified, women repeatedly petitioned both state and federal governments for the right to vote. Presents a lesson plan on a women's suffrage petition submitted to Congress in 1869. Includes the background of the petition, the petition's text, and suggested teaching activities. (CFR)

  7. 42 CFR 83.8 - How is a petition submitted?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false How is a petition submitted? 83.8 Section 83.8... Procedures for Adding Classes of Employees to the Cohort § 83.8 How is a petition submitted? The petitioner(s... instructions for preparing and submitting a petition, including an optional petition form, are available...

  8. 49 CFR 543.7 - Processing an exemption petition.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false Processing an exemption petition. 543.7 Section... § 543.7 Processing an exemption petition. (a) NHTSA processes any complete petition. If a manufacturer submits a petition that does not contain all the information required by this part, NHTSA informs...

  9. 19 CFR 171.1 - Petition for relief.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... non-commercial violations, a non-English speaking petitioner or petitioner who has a disability which... support of the petition be in English or be accompanied by an English translation. The petition must set.... (d) False statement in petition. A false statement contained in a petition may subject the...

  10. 37 CFR 2.146 - Petitions to the Director.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2012-07-01 2012-07-01 false Petitions to the Director. 2..., DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Petitions and Action by the Director § 2.146 Petitions to the Director. (a) Petition may be taken to the Director: (1) From any repeated or final...

  11. 37 CFR 2.146 - Petitions to the Director.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2011-07-01 2011-07-01 false Petitions to the Director. 2..., DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Petitions and Action by the Director § 2.146 Petitions to the Director. (a) Petition may be taken to the Director: (1) From any repeated or final...

  12. 37 CFR 2.146 - Petitions to the Director.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Petitions to the Director. 2..., DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Petitions and Action by the Director § 2.146 Petitions to the Director. (a) Petition may be taken to the Director: (1) From any repeated or final...

  13. 37 CFR 2.146 - Petitions to the Director.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Petitions to the Director. 2..., DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Petitions and Action by the Director § 2.146 Petitions to the Director. (a) Petition may be taken to the Director: (1) From any repeated or final...

  14. 37 CFR 2.146 - Petitions to the Director.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2013-07-01 2013-07-01 false Petitions to the Director. 2..., DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Petitions and Action by the Director § 2.146 Petitions to the Director. (a) Petition may be taken to the Director: (1) From any repeated or final...

  15. 77 FR 665 - Endangered and Threatened Wildlife and Plants; Listing Two Distinct Population Segments of Broad...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-05

    ...-day finding (73 FR 33968, published on June 16, 2008). We received comments from foreign government... listed this species as endangered on June 14, 1976 (41 FR 24062), in response to a petition we received... Federal Register a 90-day finding (73 FR 33968) on the petition, stating that the petition...

  16. 43 CFR 3191.1-1 - Petition.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Petition. 3191.1-1 Section 3191.1-1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT... CONTRACTS FOR OIL AND GAS INSPECTION Delegation of Authority § 3191.1-1 Petition. The Governor or...

  17. 40 CFR 82.120 - Petitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 17 2011-07-01 2011-07-01 false Petitions. 82.120 Section 82.120 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PROTECTION OF STRATOSPHERIC OZONE The Labeling of Products Using Ozone-Depleting Substances § 82.120 Petitions....

  18. 40 CFR 1700.12 - Petition requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... discharge. (2) The environmental effects of the discharge. (3) The practicability of using a Marine Pollution Control Device. (4) The effect that installation or use of the Marine Pollution Control Device... VESSELS OF THE ARMED FORCES Effect on States State Petition for Review § 1700.12 Petition requirements....

  19. 43 CFR 3191.1-1 - Petition.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Petition. 3191.1-1 Section 3191.1-1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT... CONTRACTS FOR OIL AND GAS INSPECTION Delegation of Authority § 3191.1-1 Petition. The Governor or...

  20. 40 CFR 96.275 - Petitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 22 2013-07-01 2013-07-01 false Petitions. 96.275 Section 96.275 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO 2 TRADING PROGRAMS FOR STATE IMPLEMENTATION PLANS Monitoring and Reporting § 96.275 Petitions. (a) The...

  1. 21 CFR 102.19 - Petitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Petitions. 102.19 Section 102.19 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION COMMON OR USUAL NAME FOR NONSTANDARDIZED FOODS General Provisions § 102.19 Petitions. (a)...

  2. 40 CFR 96.275 - Petitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Petitions. 96.275 Section 96.275 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS FOR STATE IMPLEMENTATION PLANS Monitoring and Reporting § 96.275 Petitions. (a) The...

  3. 40 CFR 82.120 - Petitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... petitions are under review by the Agency. (b) Requirement for adequate data. Any petition submitted under... or laboratory tests, literature, or economic analysis described in paragraphs (c) (5), (6) and (7) of....” which fully explains any values taken from literature or estimated on the basis of known...

  4. 16 CFR 1702.17 - Granting petitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Granting petitions. 1702.17 Section 1702.17 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS... REQUIREMENTS § 1702.17 Granting petitions. Where the Commission determines that reasonable grounds for...

  5. 40 CFR 82.120 - Petitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... petitions are under review by the Agency. (b) Requirement for adequate data. Any petition submitted under... or laboratory tests, literature, or economic analysis described in paragraphs (c) (5), (6) and (7) of....” which fully explains any values taken from literature or estimated on the basis of known...

  6. 40 CFR 82.120 - Petitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... petitions are under review by the Agency. (b) Requirement for adequate data. Any petition submitted under... or laboratory tests, literature, or economic analysis described in paragraphs (c) (5), (6) and (7) of....” which fully explains any values taken from literature or estimated on the basis of known...

  7. 21 CFR 509.5 - Petitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... RELATED PRODUCTS UNAVOIDABLE CONTAMINANTS IN ANIMAL FOOD AND FOOD-PACKAGING MATERIAL General Provisions § 509.5 Petitions. The Commissioner of Food and Drugs, either on his own initiative or on behalf of any... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Petitions. 509.5 Section 509.5 Food and Drugs...

  8. 21 CFR 71.1 - Petitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Petitions. 71.1 Section 71.1 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL COLOR ADDITIVE PETITIONS... for use in or on any food, drug, or cosmetic or for coloring the human body. Such proposal shall...

  9. 12 CFR 907.10 - Petitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... appearance before the Board of Directors at any meeting convened to consider the Petition pursuant to these... Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOUSING FINANCE BOARD ORGANIZATION AND OPERATIONS PROCEDURES... Petition shall be in writing. The original and three copies shall be filed with the Secretary to the...

  10. 40 CFR 96.275 - Petitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 22 2012-07-01 2012-07-01 false Petitions. 96.275 Section 96.275 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS FOR STATE IMPLEMENTATION PLANS Monitoring and Reporting § 96.275 Petitions. (a) The...

  11. 40 CFR 96.275 - Petitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 21 2014-07-01 2014-07-01 false Petitions. 96.275 Section 96.275 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS FOR STATE IMPLEMENTATION PLANS Monitoring and Reporting § 96.275 Petitions. (a) The...

  12. 49 CFR 269.7 - Petitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... certification pursuant to § 269.3(a) of this part using the following method: email to Priia214@dot.gov; (2) Describe the petition as a “Petition to Provide Passenger Rail Service under 49 CFR part 269”; and...

  13. 49 CFR 269.7 - Petitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... certification pursuant to § 269.3(a) of this part using the following method: email to Priia214@dot.gov; (2) Describe the petition as a “Petition to Provide Passenger Rail Service under 49 CFR part 269”; and...

  14. 21 CFR 71.6 - Extension of time for studying petitions; substantive amendments; withdrawal of petitions without...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Extension of time for studying petitions... Provisions § 71.6 Extension of time for studying petitions; substantive amendments; withdrawal of petitions without prejudice. (a) Extension of time for studying petitions. If the Commissioner determines...

  15. Petit receives Robert C. Cowen Award for Sustained Achievement in Science Journalism: Citation

    NASA Astrophysics Data System (ADS)

    Rademacher, Horst

    2012-01-01

    Charles W. Petit, a veteran science writer, received the 2011 Robert C. Cowan Award for Sustained Achievement in Science Journalism at the AGU Fall Meeting Honors Ceremony, held on 7 December 2011 in San Francisco, Calif. Petit covered earthquakes for the San Francisco Chronicle during the 1980s and 1990s and has recently served as "head tracker" for the Knight Science Journalism Tracker, a Massachusetts Institute of Technology-based daily blog that compiles and critiques science reporting worldwide. Petit was previously honored by AGU in 2003 when he received the David Perlman Award for an article about a new finding in oceanography. The Cowan Award, named for a former science editor of the Christian Science Monitor, is given no more than every 2 years and recognizes a journalist who has made "significant, lasting, and consistent contributions to accurate reporting or writing" on the Earth and space sciences for the general public.

  16. Petit receives Robert C. Cowen Award for Sustained Achievement in Science Journalism: Response

    NASA Astrophysics Data System (ADS)

    Petit, Charles W.

    2012-01-01

    Charles W. Petit, a veteran science writer, received the 2011 Robert C. Cowan Award for Sustained Achievement in Science Journalism at the AGU Fall Meeting Honors Ceremony, held on 7 December 2011 in San Francisco, Calif. Petit covered earthquakes for the San Francisco Chronicle during the 1980s and 1990s and has recently served as "head tracker" for the Knight Science Journalism Tracker, a Massachusetts Institute of Technology-based daily blog that compiles and critiques science reporting worldwide. Petit was previously honored by AGU in 2003 when he received the David Perlman Award for an article about a new finding in oceanography. The Cowan Award, named for a former science editor of the Christian Science Monitor, is given no more than every 2 years and recognizes a journalist who has made "significant, lasting, and consistent contributions to accurate reporting or writing" on the Earth and space sciences for the general public.

  17. 49 CFR 1155.13 - Board determination with respect to a Governor's petition.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... for a Land-Use-Exemption Permit § 1155.13 Board determination with respect to a Governor's petition... solid waste rail transfer facility, as defined in 49 U.S.C. 10908(e)(1)(H) and 49 CFR 1155.2, on October 16, 2008. If the Board finds that the facility currently does not qualify for or require a...

  18. 49 CFR 1155.13 - Board determination with respect to a Governor's petition.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... for a Land-Use-Exemption Permit § 1155.13 Board determination with respect to a Governor's petition... solid waste rail transfer facility, as defined in 49 U.S.C. 10908(e)(1)(H) and 49 CFR 1155.2, on October 16, 2008. If the Board finds that the facility currently does not qualify for or require a...

  19. 49 CFR 1155.13 - Board determination with respect to a Governor's petition.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... for a Land-Use-Exemption Permit § 1155.13 Board determination with respect to a Governor's petition... solid waste rail transfer facility, as defined in 49 U.S.C. 10908(e)(1)(H) and 49 CFR 1155.2, on October 16, 2008. If the Board finds that the facility currently does not qualify for or require a...

  20. 19 CFR 351.202 - Petition requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... to the Commission's regulations concerning the contents of petitions, currently 19 CFR 207.11. (b... to import the subject merchandise; (10) Factual information regarding material injury, threat of... Policy and Analysis, Import Administration, International Trade Administration, Room 3093,...

  1. Portable device for detection of petit mal epilepsy

    NASA Technical Reports Server (NTRS)

    Smith, R. G.; Houge, J. C.; Webster, J. G.

    1979-01-01

    A portable device that analyzes the electroencephalogram to determine if petit mal epilepsy waveforms are present is developed and tested. Clinicians should find it useful in diagnosing seizure activity of their patients. The micropower, battery-operated, portable device indicates a seizure has occurred if three criteria are satisfied: (1) frequencies of 2.5-7 Hz, (2) large-amplitude waves, and (3) minimum number of waves per second. Levels and counts are adjustable, thus insuring high reliability against noise artifacts and permitting each subject to be individually fitted. The device has shown promise in giving the patient a possible mechanism of seizure control or suppression.

  2. 42 CFR Appendix C to Part 130 - Petition Form, Petition Instructions, and Documentation Checklist

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Petition Form, Petition Instructions, and Documentation Checklist C Appendix C to Part 130 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES COMPASSIONATE PAYMENTS RICKY RAY HEMOPHILIA RELIEF FUND PROGRAM Pt. 130, App. C...

  3. 42 CFR Appendix C to Part 130 - Petition Form, Petition Instructions, and Documentation Checklist

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Petition Form, Petition Instructions, and Documentation Checklist C Appendix C to Part 130 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES COMPASSIONATE PAYMENTS RICKY RAY HEMOPHILIA RELIEF FUND PROGRAM Pt. 130, App. C...

  4. 42 CFR Appendix C to Part 130 - Petition Form, Petition Instructions, and Documentation Checklist

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Petition Form, Petition Instructions, and Documentation Checklist C Appendix C to Part 130 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES COMPASSIONATE PAYMENTS RICKY RAY HEMOPHILIA RELIEF FUND PROGRAM Pt. 130, App. C...

  5. 42 CFR Appendix C to Part 130 - Petition Form, Petition Instructions, and Documentation Checklist

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Petition Form, Petition Instructions, and Documentation Checklist C Appendix C to Part 130 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES COMPASSIONATE PAYMENTS RICKY RAY HEMOPHILIA RELIEF FUND PROGRAM Pt. 130, App. C...

  6. 42 CFR Appendix C to Part 130 - Petition Form, Petition Instructions, and Documentation Checklist

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Petition Form, Petition Instructions, and Documentation Checklist C Appendix C to Part 130 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES COMPASSIONATE PAYMENTS RICKY RAY HEMOPHILIA RELIEF FUND PROGRAM Pt. 130, App. C...

  7. 76 FR 77533 - Mandatory Electronic Filing for Cable Special Relief Petitions and Cable Show Cause Petitions...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-13

    ...: This document announces the implementation of electronic filing of Cable Special Relief (CSR) Petitions... filing of CSR and CSC petitions will be permitted through January 3, 2012, when electronic filing will... Tillery of the Media Bureau at (202) 418-1056. SUPPLEMENTARY INFORMATION: This is a summary of the CSR...

  8. 78 FR 24404 - Kootenai Electric Cooperative, Inc.; Notice of Petition for Declaratory Order and Petition for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Kootenai Electric Cooperative, Inc.; Notice of Petition for Declaratory Order and Petition for Enforcement Take notice that on April 16, 2013, pursuant to section 210(h)(2) of the Public Utility Regulatory Policies...

  9. 77 FR 65332 - Rulemaking Petition: Electioneering Communications Reporting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-26

    ...; ] FEDERAL ELECTION COMMISSION 11 CFR Part 104 Rulemaking Petition: Electioneering Communications Reporting.... See REG 2012-01 Electioneering Communications Reporting (2012). The Petition urges the Commission to revise the regulations regarding the reporting of electioneering communications. DATES: Statements...

  10. 46 CFR 502.72 - Petition for leave to intervene.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... expected to assist in the development of a sound record. (3) The timeliness of the petition will also be... section. If filed after hearings have been closed, a petition will not ordinarily be granted. (c) In...

  11. 19 CFR 171.1 - Petition for relief.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... non-commercial violations, a non-English speaking petitioner or petitioner who has a disability which... support of the petition be in English or be accompanied by an English translation. The petition must...

  12. 19 CFR 171.1 - Petition for relief.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... non-commercial violations, a non-English speaking petitioner or petitioner who has a disability which... support of the petition be in English or be accompanied by an English translation. The petition must...

  13. 19 CFR 181.116 - Petition regarding adverse marking decision.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Customs Bulletin. (3) Effect of granting the petition. The decision on the petition, if contrary to the... from warehouse for consumption after 30 days from the date on which the notice of determination...

  14. 75 FR 6339 - California Public Utilities Commission Petition for Rulemaking

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-09

    ... Rulemaking Proceedings, 63 FR 24121 (1998). Electronic Filers: Comments may be filed electronically using the... COMMISSION 47 CFR Part 4 California Public Utilities Commission Petition for Rulemaking AGENCY: Federal Communications Commission. ACTION: Petition for rulemaking. SUMMARY: The California Public Utilities...

  15. 5 CFR 1201.119 - OPM petition for reconsideration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) That the Board's decision will have a substantial impact on a civil service law, rule, regulation, or policy directive. (b) Time limit. The Director must file the petition for reconsideration within 35 days... same time as the petition for reconsideration....

  16. Peste des Petits Ruminants Virus.

    PubMed

    Baron, M D; Diallo, A; Lancelot, R; Libeau, G

    2016-01-01

    Peste des petits ruminants virus (PPRV) causes a severe contagious disease of sheep and goats and has spread extensively through the developing world. Because of its disproportionately large impact on the livelihoods of low-income livestock keepers, and the availability of effective vaccines and good diagnostics, the virus is being targeted for global control and eventual eradication. In this review we examine the origin of the virus and its current distribution, and the factors that have led international organizations to conclude that it is eradicable. We also review recent progress in the molecular and cellular biology of the virus and consider areas where further research is required to support the efforts being made by national, regional, and international bodies to tackle this growing threat. PMID:27112279

  17. 21 CFR 60.34 - FDA action on petitions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 1 2014-04-01 2014-04-01 false FDA action on petitions. 60.34 Section 60.34 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PATENT TERM... not exercise due diligence such that, even if the petition were granted, the petition would not...

  18. 21 CFR 60.34 - FDA action on petitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 1 2012-04-01 2012-04-01 false FDA action on petitions. 60.34 Section 60.34 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PATENT TERM... not exercise due diligence such that, even if the petition were granted, the petition would not...

  19. 21 CFR 60.34 - FDA action on petitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false FDA action on petitions. 60.34 Section 60.34 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PATENT TERM... not exercise due diligence such that, even if the petition were granted, the petition would not...

  20. 21 CFR 60.34 - FDA action on petitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 1 2011-04-01 2011-04-01 false FDA action on petitions. 60.34 Section 60.34 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PATENT TERM... not exercise due diligence such that, even if the petition were granted, the petition would not...