Science.gov

Sample records for 90-day petition finding

  1. 77 FR 45571 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To Delist the Green Turtle in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-01

    ...; 90-Day Finding on a Petition To Delist the Green Turtle in Hawaii and Notice of Status Review AGENCY...: We, NMFS, announce a 90-day finding on a petition to identify the Hawaiian population of the green... Species Act (ESA). The green turtle was listed under the ESA on July 28, 1978. Breeding populations of...

  2. 75 FR 67341 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Bay...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-02

    ... Fish and Wildlife Service 50 CFR Part 17 Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Bay Springs Salamander as Endangered AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of 90-day petition finding. SUMMARY: We, the U.S. Fish and Wildlife...

  3. 76 FR 61825 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List 29 Mollusk...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-05

    ... and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List 29 Mollusk Species as... CFR Part 17 Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List 29... term ``species'' to include ``any subspecies of fish or wildlife or plants, and any distinct...

  4. 78 FR 69376 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List 19 Species and 3...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-19

    ...We (NMFS) announce a 90-day finding on a petition to list 19 species and 3 subpopulations of sharks as threatened or endangered under the Endangered Species Act (ESA). We find that the petition presents substantial scientific or commercial information indicating that the petitioned action may be warranted for 9 species: Centrophorus harrissoni, Isogomphodon oxyrhynchus, Mustelus fasciatus,......

  5. 75 FR 41436 - Endangered and Threatened Wildlife; Notice of 90-Day Finding on a Petition to Revise Critical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-16

    ... 90-Day Finding on a Petition to Revise Critical Habitat for the Endangered Leatherback Sea Turtle... endangered leatherback sea turtle under the Endangered Species Act (ESA). We find that the petition does not... leatherback sea turtles and their habitat under our jurisdiction. FOR FURTHER INFORMATION CONTACT:...

  6. 75 FR 46894 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Mexican...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-04

    ... Fish and Wildlife Service 50 CFR Part 17 Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Mexican Gray Wolf as an Endangered Subspecies With Critical Habitat AGENCY... finding on two petitions to list the Mexican gray wolf (Canis lupus baileyi) (Mexican wolf) as...

  7. 76 FR 54423 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List All...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-01

    ... on a Petition To List All Chimpanzees (Pan troglodytes) as Endangered AGENCY: Fish and Wildlife....S. Fish and Wildlife Service, announce a 90-day finding on a petition to list all chimpanzees (Pan... listing all chimpanzees as endangered may be warranted. Therefore, with the publication of this notice,...

  8. 76 FR 67401 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List All...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-01

    ... on a Petition To List All Chimpanzees (Pan troglodytes) as Endangered AGENCY: Fish and Wildlife... to list all chimpanzees (Pan troglodytes) as endangered under the Endangered Species Act of 1973, as... 54423) a 90-day finding on a petition to list all chimpanzees (Pan troglodytes) as endangered under...

  9. 75 FR 18782 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List Thorne's...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR Fish and Wildlife Service 50 CFR Part 17 Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List Thorne's Hairstreak Butterfly as Endangered Correction In Federal...

  10. 78 FR 66675 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List Multiple Species of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-06

    ...; February 7, 1996). A species, subspecies, or DPS is ``endangered'' if it is in danger of extinction... extinction risk of concern for the species at issue. To make a 90-day finding on a petition to list a species.... Next, we evaluate whether the information indicates that the species at issue faces extinction...

  11. 76 FR 7820 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition to List the Texas Pipefish as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-11

    ... species, subspecies, or DPS is ``endangered'' if it is in danger of extinction throughout all or a... suggests an extinction risk of concern for the species at issue. To make a 90-day finding on a petition to... extinction risk that is cause for concern; this may be indicated in information expressly discussing...

  12. 77 FR 21920 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Eastern...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-12

    ...We, the U.S. Fish and Wildlife Service (Service), announce a 90-day finding on a petition to list either the Eastern population or the Southern Rocky Mountain (SRM) population of the boreal toad (Anaxyrus boreas boreas) as a distinct population segment (DPS) that is endangered or threatened under the Endangered Species Act of 1973, as amended (Act), and to designate critical habitat. Based on......

  13. 76 FR 78898 - Endangered and Threatened Wildlife; 90-Day Finding on Petition To List the Barndoor Skate, Winter...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-20

    ... from WildEarth Guardians and Friends of Animals (the petitioners) requesting that we list thorny skate... received the petition from WildEarth Guardians and Friends of Animals, we had already received a petition...-day finding will address the remaining three skate species included in the petition from...

  14. 77 FR 61559 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List Nassau Grouper as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-10

    ... a petition from the WildEarth Guardians to list goliath grouper (Epinephelus itajara), Nassau... of the WildEarth Guardians' petition, as well as the breadth and extent of the required evaluation... WildEarth Guardians' petition to list Nassau grouper. Negative findings for goliath grouper...

  15. 78 FR 23533 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To Delist the Wood Bison

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-19

    ... on a Petition To Delist the Wood Bison AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of... finding on a petition to delist the wood bison (Bison bison athabascae) under the Endangered Species Act... substantial information indicating that delisting the wood bison subspecies may be warranted. Therefore,...

  16. 78 FR 57611 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List Alabama Shad as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-19

    ... 20, 2010, the Center for Biological Diversity (CBD), Alabama Rivers Alliance, Clinch Coalition... shad may be warranted. On April 28, 2011, in response to the negative 90-day finding, CBD filed a notice of intent to sue DOC and NMFS for alleged violations of the ESA in making its finding. CBD...

  17. 77 FR 54548 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Eagle...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-05

    ... [Docket No. FWS-R8-ES-2012-0072: 4500030113] Endangered and Threatened Wildlife and Plants; 90-Day Finding... species to, or removing a species from, the Federal Lists of Endangered and Threatened Wildlife and Plants... had had portions of their genome deliberately spliced with genes from another species...

  18. 76 FR 55638 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Snowy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-08

    ... Fish and Wildlife Service 50 CFR Part 17 Endangered and Threatened Wildlife and Plants; 90-Day Finding... Kansas; the southern Texas coast into northeast Mexico; and the central Mexican plateau) (AOU 1957, pp... of plants, and any distinct population segment of any species of vertebrate fish or wildlife...

  19. 75 FR 55730 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on Petitions To Delist the Gray...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-14

    ... Fish and Wildlife Service 50 CFR Part 17 Endangered and Threatened Wildlife and Plants; 90-Day Finding... the 1973 Act, published in May 1974 (USDI 1974). A third gray wolf subspecies, the Mexican wolf (C. l... ``any species or subspecies of fish and wildlife or plants, and any distinct vertebrate...

  20. 77 FR 70733 - Listing Endangered or Threatened Species: 90-Day Finding on a Petition To Delist the Southern...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-27

    ... publicly accessible. Do not submit Confidential Business Information or otherwise sensitive or protected... make a finding on whether that petition presents substantial scientific or commercial information... letters from authorities, and maps (50 CFR 424.14(b)(2)). Judicial decisions have clarified...

  1. 77 FR 39670 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List a Distinct...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-05

    ... conduct a species status review, which we subsequently summarize in our 12-month finding. Petition History...). According to Hall (1981, p. 950), there are 16 subspecies of black bear in North America. Collectively, these subspecies number approximately 800,000-900,000 bears in North America with about 400,000 in...

  2. 77 FR 47352 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List Graptopetalum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-08

    ..., Interior. ACTION: Notice of petition finding and initiation of status review. SUMMARY: We, the U.S. Fish... is a spreadsheet in Microsoft Excel. (2) By hard copy: Submit by U.S. mail or hand-delivery to: Public Comments Processing, Attn: FWS-R2-ES-2012-0047; Division of Policy and Directives Management;...

  3. 76 FR 25660 - Endangered and Threatened Wildlife; Notice of 90-Day Finding on a Petition to Revise Critical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-05

    ... Sea Turtle Under the Endangered Species Act AGENCY: National Marine Fisheries Service (NMFS), National... endangered ] leatherback sea turtle under the Endangered Species Act (ESA). We find that the petition... leatherback sea turtles and their habitat under our jurisdiction. FOR FURTHER INFORMATION CONTACT:...

  4. 77 FR 55458 - Endangered and Threatened Species; 90-Day Finding on Petition To Delist the Southern Oregon...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-10

    ... Finding on Petition To Delist the Southern Oregon/Northern California Coast Evolutionarily Significant... California Coast (SONCC) Evolutionarily Significant Unit (ESU) of coho salmon (Oncorhynchus kisutch) under... California watersheds, including the Klamath River, the species abundance has increased since the early...

  5. 75 FR 52928 - Endangered and Threatened Wildlife and Plants; Notice of 90-Day Finding for a Petition to List...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-30

    ... finding, we consider the Georgia Basin to include the inland marine waters of Puget Sound, the Strait of... segments of Puget Sound/Georgia Basin distinct population segments of rockfish, 75 FR 22276 (April 28, 2010... (currently within our files). Previous Petition to list Puget Sound China Rockfish and Tiger Rockfish We...

  6. 77 FR 1668 - Endangered and Threatened Species; 90-Day Finding on Petition To Delist the Southern Oregon...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-11

    ... Unit of Coho Salmon Under the Endangered Species Act AGENCY: National Marine Fisheries Service (NMFS... the Endangered Species Act (ESA). We find that the petition does not present substantial scientific or... National Oceanic and Atmospheric Administration RIN 0648-XA851 Endangered and Threatened Species;...

  7. 78 FR 58507 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List 10 Sturgeon...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-24

    ... construction, and water pollution. The petition is available at http://www.nmfs.noaa.gov/pr/pdfs/petitions... sturgeon (Acipenser baerii). Endangered Decreasing China; Kazakhstan; Mongolia; Russia. Yangtze sturgeon (Acipenser Critically Endangered.. Decreasing China. dabryanus). Russian sturgeon (Acipenser...

  8. 77 FR 9618 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-17

    ... to the same species as) their T. thermophila, although here the petition paraphrased this statement... generic descriptions, nor does it provide any other morphological, ecological, distributional, genetic,...

  9. 78 FR 24701 - Endangered and Threatened Wildlife; 90-Day Finding on Petitions To List the Great Hammerhead...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-26

    ... petitioned action ``may be'' warranted. As a general matter, these decisions hold that a petition need not... dorsal side colored dark brown to light grey or olive that shades to white on the ventral side (Compagno... or, for that matter, any enforcement, with some countries lacking basic monitoring systems....

  10. 77 FR 24908 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List Aliciella...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-26

    ... History On February 12, 2010, we received a petition from the WildEarth Guardians, dated February 12, 2010... can alter water flows, destabilize slopes, and offer increased access by ORVs (WildEarth Guardians..., letter to WildEarth Guardians, we acknowledged receipt of the petition, and reviewed the...

  11. 77 FR 59582 - Endangered and Threatened Wildlife; 90-Day Finding on Petitions To List the Northeastern Pacific...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-28

    ... et al., 2012). The WildEarth Guardians petition briefly states that water quality in areas off Mexico... June 25, 2012, we received a petition from WildEarth Guardians to list the northeastern Pacific Ocean... extinction risk and impacts or threats discussed above. Distribution and Life History of the Great...

  12. 76 FR 31920 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Golden...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-02

    ... commercial, recreational, scientific, or educational purposes; (c) Disease or predation; (d) The inadequacy... commercial, recreational, scientific, or educational purposes; (C) Disease or predation; (D) The inadequacy... Predation Information Provided in the Petition The petition did not present any information with respect...

  13. 77 FR 43799 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Gila...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-26

    ... 2010, p. 2). The petition states that aluminum is toxic to aquatic insects and cite several papers in... of pollutants from roads and off-road vehicle trails, introduction of bacteria and excess nutrients... warranted. The petition states that aluminum is toxic to aquatic insects and cite several papers in...

  14. 77 FR 26478 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List the Dwarf Seahorse as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-04

    ... action ``may be'' warranted. As a general matter, these decisions hold that a petition need not establish...; individuals can be beige, yellow, green, or black, and some individuals have white marking or dark...

  15. 76 FR 56607 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List 42 Great...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-13

    ..., pumping, etc.), spring development, water pollution, recreation, grazing, invasive species, global climate... development, water pollution, recreation, and grazing are threats that may affect the five petitioned Railroad... being implemented to avoid threats such as spring development, water pollution, recreation, and...

  16. 75 FR 6616 - Endangered and Threatened Wildlife; Notice of 90-Day Finding on a Petition to List 83 Species of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-10

    ... in danger of extinction throughout all or a significant portion of its range, and ``threatened'' if... fishes, and serve as food resources for a variety of animals. Analysis of Petition Of the 83...

  17. 78 FR 53391 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To Delist the North Pacific...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-29

    ... a determination that a petitioned action may be warranted. As a general matter, these decisions hold... patterning, dark dorsal coloration, a highly varied acoustic call (termed song) and a diverse repertoire of...., 1995). There are significantly more dark-colored flukes in the North Pacific populations of...

  18. 76 FR 38095 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Eastern...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    ... insects are high (MacGregor and Kiser 1998, p. 175). Chenger (2008, pp. 10, 69-71) observed a female... forage on a variety of small insects, including moths, flies, leafhoppers, and beetles (Nagorsen and... eradicate local insect populations, effectively excluding bats from their former habitats (Petition, p....

  19. 75 FR 59690 - Endangered and Threatened Wildlife; Notice of 90-Day Finding on a Petition To List Warsaw Grouper...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-28

    ...Earth Guardians to list warsaw grouper (Epinephelus nigritus) as threatened or endangered under the ESA... western Caribbean shelf may be due to the dearth of deep-water fishing in this area (Heemstra and Randall... history. Information on Extinction Risk The petition cites classifications made by NMFS, the...

  20. 78 FR 63941 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List 23 Species of Corals as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-25

    ... WildEarth Guardians to list 81 marine species as threatened or endangered under the ESA and to...). Species Description Most of the petitioned coral species are shallow water, reef- building anthozoan... offers no species-specific life history, abundance, or threat information (see discussion of...

  1. 75 FR 13717 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List the Southern...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-23

    ... History On October 15, 2008, we received a petition, dated October 9, 2008, from WildEarth Guardians... river drainages (WildEarth Guardians 2008, p. 10; NatureServe 2008); and round hickorynut (Obovaria..., and that it has been extirpated from two sites in Alabama (WildEarth Guardians 2008, pp. 11-12)....

  2. 76 FR 78891 - Listing Endangered and Threatened Wildlife and Plants; 90-Day Finding on Petitions To List the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-20

    ... for the thorny skate in U.S. waters. On August 23, 2011, we received a petition from WildEarth... warranted. The petitioners claim that the species' life history characteristics and limited ability to...Earth Guardians and Friends of Animals request that if the Secretary determines that the thorny skate...

  3. 76 FR 49412 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List the Saltmarsh Topminnow...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-10

    ... received a petition from WildEarth Guardians and Ms. Sarah Felsen to list the saltmarsh topminnow (Fundulus... threats discussed above. Distribution and Life History of Saltmarsh Topminnow The saltmarsh topminnow is... contain topminnows (Thompson, 1980; Peterson et al., 2003). In addition to salinity, water depth,...

  4. 78 FR 29100 - Endangered and Threatened Wildlife; 90-Day Finding on Petitions To List the Dusky Shark as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-17

    ... the surface to depths as deep as 1,883 feet (574 m) (NOAA, 1998; Hoffmayer et al., 2010; NMFS, 2011a..., moving north in the summer as waters warm and retreating south in the fall as water temperatures drop... Population Analysis The WEG petition identifies the 2010 Deepwater Horizon oil spill as an event that...

  5. 78 FR 46322 - Endangered and Threatened Species; 90-Day Finding on Petition To Delist the Southern Oregon...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-31

    ... factor for the low abundance of coho salmon at the time of listing in 1997 was poor ocean conditions in... prolonged period of poor ocean conditions and low salmon abundance. The SCWUA petition simply repeats... researchers had suggested mechanisms linking atmospheric and ocean physics and ocean fish populations...

  6. 75 FR 23654 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List Hermes Copper...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-04

    ... on a Petition to List Hermes Copper Butterfly as Threatened or Endangered AGENCY: Fish and Wildlife... copper butterfly (Hermelycaena hermes) as a threatened or endangered species under the Endangered Species... substantial scientific or commercial information indicating that listing the Hermes copper butterfly may...

  7. 75 FR 21568 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List the Harlequin...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... on a Petition to List the Harlequin Butterfly as Endangered AGENCY: Fish and Wildlife Service... butterfly (Atlantea tulita), a butterfly endemic to Puerto Rico, as endangered under the Endangered Species... butterfly may be warranted. Therefore, with the publication of this notice, we are initiating a review...

  8. 75 FR 17062 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List Thorne's...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-05

    ... on a Petition To List Thorne's Hairstreak Butterfly as or Endangered AGENCY: Fish and Wildlife... hairstreak butterfly (Callophrys grynea thornei or Callophrys thornei) as endangered under the Endangered... listing Thorne's hairstreak butterfly may be warranted. Therefore, with the publication of this notice,...

  9. 76 FR 10310 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-24

    ... on a Petition To List the Unsilvered Fritillary Butterfly as Threatened or Endangered AGENCY: Fish... butterfly (Speyeria adiaste) as threatened or endangered under the Endangered Species Act of 1973 (Act), as..., dated January 6, 2010, from WildEarth Guardians, requesting that the unsilvered fritillary butterfly...

  10. 78 FR 6299 - Endangered and Threatened Wildlife; 90-Day Finding on Two Petitions To List White Marlin as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-30

    ... petition to list white marlin from the Center for Biological Diversity (CBD) on April 3, 2012. Copies of.... Chambers and CBD requesting us to list white marlin under the ESA. We have previously reviewed the status... between NMFS, CBD, and the Turtle Island Restoration Network, we revisited the status of the white...

  11. 76 FR 20302 - Listing Endangered and Threatened Species; 90-Day Finding on a Petition To List Chinook Salmon

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-12

    ... Rivers Basin as threatened or endangered and designate critical habitat under the Endangered Species Act... Trinity Rivers Basin to determine if the petitioned actions are warranted. To ensure that the review is... salmon. Because their request is generally made in reference to the Upper Klamath and Trinity...

  12. 77 FR 37367 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List the Black...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-21

    ... South Atlantic, the South Pacific, and the southern Indian Ocean (Farnsworth 2010, p. 5). Farnswoth... on high mountain ridges at breeding locations, because during nightly courtship flights the birds fly... petition claims that extensive hunting is known to have occurred in Guadeloupe back to at least the...

  13. 76 FR 31903 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to Reclassify the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-02

    ... on a Petition to Reclassify the Straight-Horned Markhor (Capra falconeri jerdoni) of Torghar Hills as... to reclassify the Torghar Hills population of straight-horned markhor, or Suleiman markhor, (Capra... Capra falconeri jerdoni and C. f. megaceros to determine if these two subspecies constitute a...

  14. 75 FR 50739 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List Brian Head...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-17

    ... Forest Guardians (now WildEarth Guardians) requesting that the Service: (1) Consider for listing all full... a petition from WildEarth Guardians dated June 12, 2008, to emergency list 32 species including the..., complaint from WildEarth Guardians, we agreed, under a June 28, 2010, stipulated settlement agreement,...

  15. 75 FR 51969 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List the Oklahoma...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-24

    ... on a Petition to List the Oklahoma Grass Pink Orchid as Endangered or Threatened AGENCY: Fish and... Calopogon oklahomensis (Oklahoma grass pink orchid) as endangered or threatened under the Endangered Species... orchid) from governmental agencies, Native American Tribes, the scientific community, industry, and...

  16. 77 FR 39666 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List Maytenus cymosa

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-05

    ... History On October 6, 2011, we received a petition, dated September 28, 2011, from Mark N. Salvo of Wild... Celastraceae family. It grows up to 8 meters (m) (26.7 feet (ft)) tall and the trunk diameter may reach up...

  17. 76 FR 15947 - Endangered and Threatened Wildlife; Notice of 90-Day Finding on a Petition To List the Caribbean...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-22

    ..., including: the abortion of embryos by gravid females when stressed, low survival rates of incidentally.... Furthermore, abortion of embryos by captured gravid females is of concern. While specific catch data are..., Shepherd and Myers 2005). The petition also cites the abortion of embryos by gravid females caught...

  18. 77 FR 51767 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List Five Species of Sturgeon...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-27

    ... WildEarth Guardians and Friends of Animals to list 15 species of sturgeon (Acipenser naccarii--Adriatic..., Norway, Portugal, Spain, Tunisia and the United Kingdom. According to the petitioner and IUCN, its... sites. The petition also cites the 16th Meeting of the CITES Animals Committee in December 2000,...

  19. 76 FR 20911 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Prairie...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-14

    ... accepted by the scientific community. The prairie chub is listed as a species in the Common and Scientific... species that have invaded the Red River basin include common carp (Cyprinus carpio), threadfin shad... species mentioned in the petition (common carp, threadfin shad, and inland silverside) may be acting...

  20. 75 FR 1567 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List the Eastern...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-12

    ... on a Petition to List the Eastern Population of the Gopher Tortoise as Threatened AGENCY: Fish and... population of the gopher tortoise (Gopherus polyphemus) as threatened under the Endangered Species Act of... eastern population of the gopher tortoise (Gopherus polyphemus) as threatened in the Federal Register...

  1. 76 FR 59835 - Endangered and Threatened Wildlife and Plants; Partial 90-Day Finding on a Petition To List 404...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-27

    ...), please call the Federal Information Relay Service (FIRS) at 800-877-8339. SUPPLEMENTARY INFORMATION... included 15 amphibians, 6 amphipods, 18 beetles, 3 birds, 4 butterflies, 9 caddisflies, 83 crayfish, 14... listing, until that category was discontinued in 1996. The petition identified three birds and...

  2. 76 FR 304 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Red Knot...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-04

    ... telecommunications device for the deaf (TDD), please call the Federal Information Relay Service (FIRS) at 800-877... Littoral Society, American Bird Conservancy, Delaware Audubon, Delaware Nature Society, Delaware... subspecies and the roselaari subspecies.'' The petition further calls for a ``national listing based...

  3. 77 FR 4973 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List the San...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-01

    ... occidentalis), martens (Martes americana), domestic house cats (Felis catus), wolves (Canis lupus), weasels... petition also includes the potential threat of house cat predation, which we discuss below under Factor C... notes that San Bernardino flying squirrels face an increasing risk of predation from domestic house...

  4. Trichloromelamine 14-Day Range Finding and 90-Day Subchronic Studies in Rats. 3 August 1988 - 17 January 1989. Phase 2

    DTIC Science & Technology

    1992-11-13

    COSATI CODES 10. SUBJECT TERMS (Continue on reverne if necessary and identify by block number) FIELD GROUP SUB-GROUP Trichloroemelamine, toxicity , 14-Day...90-Day 19, ABSTRACT (Conamnue on revers if necessary and identify by block number) The subchronic study examined the toxicity of the food service...observed adverse effect level in the 90-day study was 30 mg/kg/day. Trichloromelamine should be considered moderately toxic when ingested acutely

  5. Range Finding 14-Day and 90-Day Subchronic Feeding Studies with N,N-Dipropylcyclohexanecarboxamide in Rats. Phase 4.

    DTIC Science & Technology

    1986-12-01

    clinical chemistry values. Significant increases occurred in male rat liver organ-to-body weight ratios in all three dose levels at the 45 and 90 day necropsies during the 90-day feeding study. A no effect dose was not achieved during this study. Additional testing would be required to confirm a no effect dose level. It is concluded that a toxic hazard may exist from a prolonged significant oral exposure to N,N-Dopropylcyclohexanecarboxamide. It is recommended that further evaluation of this compound as a candidate insect repellent be discontinued due to the deleterious

  6. 90-Day Cycle Handbook

    ERIC Educational Resources Information Center

    Park, Sandra; Takahashi, Sola

    2013-01-01

    90-Day Cycles are a disciplined and structured form of inquiry designed to produce and test knowledge syntheses, prototyped processes, or products in support of improvement work. With any type of activity, organizations inevitably encounter roadblocks to improving performance and outcomes. These barriers might include intractable problems at…

  7. 77 FR 47583 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List Desert...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-09

    ...) with presumably similar timeframes of hibernation in other parts of its range. They commonly use rodent burrows for hibernation and as birthing sites (Mackessy 2005, pp. 16-17, 23; Mackessy 2007, p. 8). They... locations used for winter hibernation and those used during active periods (Ernst and Ernst 2003, p....

  8. 76 FR 9320 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List Alabama Shad as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-17

    ... Alabama shad have experienced widespread declines because of loss of habitat to dams, rapid urbanization... to rapid urbanization and pollution has contributed to the widespread declines in Alabama...

  9. 75 FR 34077 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on Five Petitions to List Seven...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-16

    ... habitat of these seven species in some locations. Habitat Destruction and Modification by Urbanization and... and shrublands have been heavily impacted by urbanization and conversion to agriculture or pasture..., or military or agricultural use, or lost to urbanization (Cuddihy and Stone 1990, p. 61;...

  10. 76 FR 51929 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To Delist the Valley...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-19

    ... and dark green (to red and black) insect approximately 0.8 inches (in.) (2 centimeters (cm)) long. It.... 2006, pp. 8-9). The larva eventually cuts an exit hole out of the stem, but plugs the hole up again..., and finally emerges from its single exit hole as an adult between mid-March and mid-June (Lang et...

  11. 77 FR 43218 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Sonoran...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-24

    ... dark peripheral band (Bequaert and Miller 1973, p. 110). Because shells of Sonorella are weakly... and decaying plant matter (Hoffman 1990, p. 7; Hoffman 1995, p. 6; AGFD 2008, p. 2). Sonorella...

  12. 77 FR 1900 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Humboldt...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-12

    ... and Kelson 1959, p. 900; Hall 1981, pp. 983-984) or cranial characters and fossil history (Clarke et... marten occurs (CBD and EPIC 2010, p. 25). In 1946, the California Fish and Game Commission closed the...) were banned in California in 1998 (California Fish and Game Code Section 3003.1). Only...

  13. 76 FR 3069 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To Delist or...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-19

    ... bicolored, with green, sparsely pubescent (covered with short, fine hairs) upper surfaces and veiny, white, and hairy under surfaces that are densely matted with branching hairs (Munz and Johnston 1924)....

  14. 76 FR 10299 - Endangered and Threatened Wildlife and Plants: 90-Day Finding on a Petition To List the Wild...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-24

    ... 1,200 lbs (318 to 545 kg) in mature females (Meagher 1986, p. 1). Bison are brown, with longer hair over the forehead, neck, shoulder hump, and front-quarters; and shorter hair over the rear and...

  15. 75 FR 42059 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Giant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-20

    ... habitat conversion, loss, and fragmentation from agriculture and urban sprawl in the Palouse region...) fields (areas set aside from farming and mainly planted with nonnative grasses), Sanchez-de Leon and... converted to agriculture or urban uses; and less than 1 percent of the original bunchgrass prairie...

  16. 76 FR 47123 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List Six Sand Dune...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-04

    ...- southeast of Fallon, Churchill County, Nevada. Sand Mountain is a star dune (roughly star-shaped) and ranges... Heritage Program 2006, p. 43). Blowsand Mountains is a complex of star and linear dunes occurring partially... 2010, p. 15). Big Dune is a complex star dune that reaches 2,731 ft (832.4 m) in elevation and...

  17. 78 FR 69033 - Endangered and Threatened Wildlife; 90-Day Finding on Petitions To List the Pinto Abalone as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-18

    ... in temperature, from 2 to 24 degrees Celsius, based on laboratory experiments (COSEWIC, 2009). Pinto... in the water column over a 5- to 10-day period (perhaps up to 13 days at cooler temperatures) before... (COSEWIC, 2009). Growth rates can vary depending on food availability, water temperature, and...

  18. 75 FR 35746 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List the Honduran...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-23

    ... distribution and abundance of this species and its principal food sources over the short and long term. (3... principal food sources over the short and long term. (5) Information on management programs for hummingbird... flowers for food but also relies on insects and spiders as a source of protein (BLI 2008, p. 3; Collar...

  19. 75 FR 13068 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List the Berry...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-18

    ... would threaten the Berry Cave salamander population by disrupting the food chain upon which the species... amount of organic matter (salamander food source) entering the cave complex. It could also...

  20. 75 FR 57431 - Listing Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-21

    ... global climate change that affect ocean temperatures, currents, and potentially food chain dynamics, are... bluefin tuna in the Mediterranean. CBD also states that mercury may accumulate in the food chain due...

  1. 77 FR 51763 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List the Queen Conch as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-27

    ... habitat degradation, specifically, water pollution and destruction of seagrass nursery habitat... concern to the queen conch. The petitioner also claims that water pollution in the form of heavy metals is...'' listing factor. However, the available information suggests that water pollution is having a...

  2. 75 FR 77602 - Endangered and Threatened Species; 90-Day Finding on Petitions To Delist the Eastern Distinct...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-13

    ... revising the Lists of Endangered and Threatened Wildlife and Plants (50 CFR 424). The regulations provide... percent per year since the late 1970s (Pitcher et al. 2007, as cited in NMFS 2008:x). The Executive... the eastern DPS and consider removing it from the Federal List of Endangered Wildlife and...

  3. 76 FR 12308 - Listing Endangered and Threatened Species: 90-Day Finding on a Petition to List Six Species of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-07

    ... NOAA-U.S. Fish and Wildlife Service (USFWS) (jointly, ``the Services'') policy clarifies the agencies... subsist chiefly on small schooling fishes, such as mullets and clupeids. They also reported that they feed... the literature on observations of sawfish feeding behavior, noted that they attack fish by...

  4. 76 FR 31592 - Endangered and Threatened Wildlife; Notice of 90-Day Finding on a Petition To List Goliath...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-01

    ... the Gulf of Mexico and South Atlantic EEZ, as well as Florida, and the species has demonstrated a... Regional Office, NMFS, 263 13th Avenue South, St. Petersburg, FL 33701. FOR FURTHER INFORMATION CONTACT... Atlantic, the species is distributed from Bermuda and the Carolinas, south into the Gulf of Mexico...

  5. 78 FR 29098 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List Iliamna Lake Seals as a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-17

    ... Diversity (CBD) to list the harbor seals in Iliamna Lake, Alaska as a threatened or endangered species under... considered as part of the Bristol Bay harbor seal stock. CBD asserts that the harbor seals found in Iliamna... seals.'' CBD asserts that the seals in Iliamna Lake face the following threats: (1) Habitat...

  6. 77 FR 70727 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List the African...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-27

    ...) Historical and current range, including distribution patterns; (d) Historical and current population levels, and current and projected trends; and (e) Past and ongoing conservation measures for the species and... indirectly through changes in regional climate; and (b) Quantitative research on the relationship of...

  7. 78 FR 72622 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List 11 Tarantula...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-03

    ... species, such as harvest, domestic and foreign trade, habitat destruction, intentional killing, or other.... Poecilotheria subfusca brown parachute Sri Lanka. spider, ivory ornamental tarantula, ivory bird-eating... forest habitat, collection for the pet trade, intentional killing, inadequate regulatory...

  8. 76 FR 40868 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Bay...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-12

    ... 1989; Vaughan and Shepherd 2005; Butterflies and Moths of North America (BMNA) 2009). The Bay skipper... wide variety of vertebrate and invertebrate wildlife (e.g., birds, reptiles, amphibians, other...

  9. 75 FR 22063 - Endangered and Threatened Wildlife and Plants; 90-day Finding on a Petition to List the Mohave...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-27

    ...) Overutilization for commercial, recreational, scientific, or educational purposes; (c) Disease or predation; (d... occurrence and extent/ severity of predation by coyotes, house cats, common ravens, domestic dogs, and feral dogs on the Mohave ground squirrel, and the effect of this predation on the Mohave ground...

  10. 76 FR 67652 - Listing Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-02

    ... or predation; (4) inadequacy of existing regulatory mechanisms; and (5) other natural or man-made...-utilization for commercial, recreational, scientific, or educational purposes; (3) disease or predation; (4.... Predation and Disease The NRDC identifies predation and disease as another threat facing river...

  11. 78 FR 55046 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To Delist or...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-09

    ... var. kuenzleri (Kuenzler hedgehog cactus), and Sclerocactus brevihamatus ssp. tobuschii (Tobusch... var. kuenzleri (Kuenzler hedgehog cactus), and Ancistrocactus tobuschii (an accepted synonym for... species to threatened. Kuenzler Hedgehog Cactus The Kuenzler hedgehog cactus was federally listed...

  12. 78 FR 13614 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List the Humphead Wrasse as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-28

    ... include destruction and degradation of coral reef habitat, human population growth, climate change, and... fishing pressure. For example, Scales et al. (2007) documented exponential declines in relative abundance... predicted to continue or even accelerate with the expected growth of the live reef fish food trade...

  13. 75 FR 48294 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-10

    ... potential effects of climate change on this species and its habitat. If, after the status review, we... botanical gardens (USFWS 2003, p. 96; Chasse et al. 2009, p. 7). Modern botanical collections of this plant... that potential threats to the species exist due to climate change, unregulated off-leash dog...

  14. 77 FR 71759 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Prairie...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-04

    ... successional (process by which ecological communities undergo changes following disturbance) component to their... of Arkansas varied by gender and season. The home ranges of males (222 to 1,824 ha (548.6 to...

  15. 75 FR 17363 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List a Stonefly...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-06

    ... collected at a third site in 1978 and 1980 from the Rio Grande, upstream from Radium Springs, Dona Ana.... Concerning the population near Radium Springs, New Mexico, Jacobi et al. (2005) note that the site is in...

  16. 78 FR 25044 - Listing Endangered or Threatened Species: 90-Day Finding on a Petition To Include the Killer...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-29

    ... Ethical Treatment of Animals Foundation on behalf of the Animal Legal Defense Fund, Orca Network, Howard... ``endangered'' if it is in danger of extinction throughout all or a significant portion of its range,...

  17. 76 FR 50971 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Leona's...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    ... danger on the Mazama Tree Farm due to a high density of lodgepole pine (Milstein 2008). It is uncertain... applications completed by the Service and the U.S. Department of Agriculture's Animal and Plant Health... danger on the Mazama Tree Farm due to a high density of lodgepole pine (Milstein 2008). It is...

  18. 75 FR 39656 - Listing Endangered and Threatened Wildlife and Plants; 90-Day Finding on Petitions to List the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-12

    ... species (16 U.S.C. 1532 (16)). The ESA defines an endangered species as ``any species which is in danger... animals have a higher capacity for buffering pH changes, and that the tolerance of CO2 by marine fish appears to be very high. Porbeagle sharks are an active, highly migratory species, and active animals...

  19. 76 FR 72891 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List the Scalloped Hammerhead...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... WildEarth Guardians and Friends of Animals to list the scalloped hammerhead shark (Sphyrna lewini) as..., or DPS is ``endangered'' if it is in danger of extinction throughout all or a significant portion of... species. During our status review, we will first determine whether the species is in danger of...

  20. 78 FR 50032 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List the Whale Shark as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ... FR 4722; February 7, 1996). A species, subspecies, or DPS is ``endangered'' if it is in danger of..., and identification of larger aggregations of animals in previously unknown locations suggests that...,401-179,794 animals. While these values are only rough estimates of the actual effective...

  1. 75 FR 16713 - Endangered and Threatened Wildlife; Notice of 90-Day Finding on a Petition to List the Bumphead...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-02

    ... subspecies is ``endangered'' if it is in danger of extinction throughout all or a significant portion of its... bumphead parrot fish were caught years ago, but very few are found now. Respondents stated that 250 animals... caught in a month after 1990, and the animals were half the size. The interviews suggested that...

  2. 76 FR 56381 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Franklin...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-13

    ... mechanisms; or (e) Other natural or manmade factors affecting its continued existence. (3) Information on... that the species may be extinct (Natural Research Council 2007, p. 43; NatureServe 2010, p. 1), we do... regulatory mechanisms; or (E) Other natural or manmade factors affecting its continued existence....

  3. 76 FR 30082 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Spot...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-24

    ... natural or manmade factors affecting its continued existence. (3) Information related to the specific... regulatory mechanisms; or (E) Other natural or manmade factors affecting its continued existence. In... existing regulator mechanisms. E. Other Natural or Manmade Factors Affecting Its Continued...

  4. 76 FR 9309 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Sand...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-17

    ...) Disease or predation; (d) The inadequacy of existing regulatory mechanisms; or (e) Other natural or... Department of Natural Resources, Natural Heritage Program (COSEWIC 2003, pp. v-vi), nor is it considered a...) Other natural or manmade factors affecting its continued existence. In considering what factors...

  5. 76 FR 23256 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Arapahoe...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-26

    ... regulatory mechanisms; or (e) Other natural or manmade factors affecting its continued existence. If, after... regulatory mechanisms; or (E) Other natural or manmade factors affecting its continued existence. In... from spraying insecticide, tree thinning, and controlled burns are discussed in this section....

  6. 75 FR 16745 - Endangered and Threatened Species; 90-Day Finding on a Petition to Delist Coho Salmon South of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-02

    ... coho salmon in the archeological record; (3) differences in geology, climate, and hydrology between... similarities in climate, geology, and hydrology of watersheds in Santa Cruz and coastal San Mateo...

  7. 75 FR 13720 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List the Striped...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-23

    .... The striped newt has one of the most complex life cycles of any amphibian (Johnson 2002, p. 384... striped newt. Population models of an amphibian (California tiger salamander) with a life cycle similar to... populations. This is supported by a review conducted in Florida on the commercial harvest of amphibians...

  8. 76 FR 62259 - Endangered and Threatened Wildlife and Plants; Partial 90-Day Finding on a Petition To List 404...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-06

    ... protection under the Act. This list included 15 amphibians, 6 amphipods, 18 beetles, 3 birds, 4 butterflies... amphibians may also be eaten. Nothing is known about the specific ecology of the South Florida rainbow...

  9. 77 FR 45 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List Sierra Nevada...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-03

    ... fox habitat is threatened by logging, fire suppression, domestic livestock grazing, and recreation... states that the structural changes associated with logging and fire suppression activities could... that logging may have on the subspecies' habitat in our status review. Fire...

  10. 77 FR 52293 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List Mimulus...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-29

    ... to the mean and variability of different types of weather conditions over time, with 30 years being a... seed bank to maintain populations during dry years. Plants produce a small propagation tool (the gemma... threats of increased temperatures and more extreme weather caused by climate change, which may impact...

  11. 75 FR 316 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition to List the Insular Population...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-05

    ... theory that evolution of island-associated populations such as this population of false killer whales... contends that the small population size, evidence of a declining population trend, and multiple threats... morphological discontinuity may provide evidence of this separation); or (2) it is delimited by...

  12. 76 FR 36053 - Endangered and Threatened Wildlife and Plants; Revised 90-Day Finding on a Petition To Reclassify...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-21

    ... Commercial, Recreational, Scientific, or Educational Purposes below), sylvatic plague (a nonnative disease... plague. Factors such as low reproductive rate, genetic drift, and inbreeding may increase the potential... more susceptible to local extirpation from factors such as sylvatic plague (Miller et al. 1994, 1996...

  13. 76 FR 12683 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Texas...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-08

    ... further investigation of the potential for sylvatic plague to affect the Texas kangaroo rat (WildEarth.... Information in our files suggests that the potential for infection from sylvatic plague does exist, but...

  14. 76 FR 7528 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To Revise Critical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-10

    ..., on September 19, 1994 (59 FR 48136). Critical habitat for 4 vernal pool crustaceans and 11 vernal... August 6, 2003 (68 FR 46684). The 2003 final critical habitat for the 4 vernal pool crustaceans and 11... noneconomic exclusions for the 2005 final rule designating critical habitat for 4 vernal pool crustaceans...

  15. 77 FR 58084 - Endangered and Threatened Wildlife and Plants; 90-Day Findings on Petitions To Delist U.S...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-19

    ... that removal or delisting of the U.S. captive or U.S. captive-bred individuals of these species was... have been greatly reduced primarily as a result of habitat loss, uncontrolled killing, and...

  16. 78 FR 21086 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List Two...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-09

    ... Diversity, the Blue Mountains Biodiversity Project, and the Biodiversity Conservation Alliance (EII et al..., and current and projected trends; and (e) Past and ongoing conservation measures for the species, its... ``physical or biological features essential to the conservation of the species,'' within the...

  17. 76 FR 78601 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Western...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-19

    ... comment by clicking on ``Submit a Comment.'' (2) By hard copy: Submit by U.S. mail or hand-delivery to... measures and programs for the species, its habitat, or both. (2) The factors that are the basis for making... the conservation of the species'' within the geographical range currently occupied by the species;...

  18. 75 FR 838 - Endangered and Threatened Wildlife; Notice of 90-Day Finding on a Petition to List Atlantic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-06

    ... result of rising sea level. As described previously, Atlantic sturgeon once supported extensive... Atlantic sturgeon underwent significant range-wide declines from historical abundance levels due to... active in many rivers during all or some of the period from 1962 to 1997, although at much lower...

  19. 76 FR 20613 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List Spring...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-13

    ..., range, and population trends, including: (a) Habitat requirements for feeding, breeding, and sheltering...) Historical and current population levels, and current and projected trends; and (e) Past and ongoing.... The trend for Spring Mountains acastus checkerspot butterfly was described as ``Unknown.''...

  20. 77 FR 25687 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition to List Speckled Hind as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-01

    ... misunderstanding or misrepresentation of landings data. The 1986 to 1995 time series data in Parker and Mays (1998.... At that time, a Candidate Species was defined as any species being considered by the Secretary of... Concern list at that time because they were not being considered for ESA listing and were better...

  1. 75 FR 30313 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List Castanea pumila

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-01

    ... patterns; (d) Historical and current population levels, and current and projected trends; and (e) Past and... that letter, we advised the petitioner that, due to a significant number of court orders and settlement..., and Oklahoma (U.S. Forest Service 1999, section 5). The area of analysis overlaps much of the range...

  2. 75 FR 19925 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List a Distinct...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-16

    ... breeding season, which is generally from late February to the middle of May (Wright and Coulter 1967, p. 77... gestation is estimated to be between 30 and 60 days; and birth occurs nearly 1 year after copulation (Wright... kits are entirely dependent and may nurse for 10 weeks or more after birth (Powell 1993, p. 67)....

  3. 75 FR 32869 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List a Distinct...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-10

    ... population segment of any species of vertebrate fish or wildlife which interbreeds when mature.'' The term... evaluating whether a vertebrate population segment may be considered a DPS: (1) The discreteness of the... of a vertebrate species may be considered discrete if it satisfies either one of the...

  4. 77 FR 75091 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To Delist the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-19

    ... vertebrate fish or wildlife which interbreeds when mature.'' The National Marine Fisheries Service (NMFS) and... or endangered. A population segment of a vertebrate species may be considered discrete if it... different DPSs of the same vertebrate taxon. Previous Federal Actions The southern Selkirk...

  5. 78 FR 19176 - Endangered and Threatened Wildlife; 90-day Finding on a Petition to List Sperm Whales in the Gulf...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-29

    ... ESA, the term ``species'' means a species, a subspecies, or a DPS of a vertebrate species (16 U.S.C... elements when evaluating whether a vertebrate population segment qualifies as a DPS under the ESA: (1... belongs. A population segment of a vertebrate species may be considered discrete if it satisfies...

  6. 76 FR 18701 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Peary...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-05

    ... Nations Framework Convention on Climate Change (UNFCCC), the Kyoto Protocol, and United States climate... restrictions on GHG emissions. The Kyoto Protocol became the first agreement to set GHG emissions targets...

  7. 76 FR 36049 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Utah...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-21

    ... applications, including the treatment of Type 2 diabetes and possibly memory disorders, such as Alzheimer's... physical, physiological, ecological, or behavioral factors (quantitative measures of genetic or... markedly from other populations of the species in its genetic characteristics. We concluded in the...

  8. 77 FR 27403 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Eastern...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-10

    ... Canada (ITIS) (retrieved November 9, 2011, from the Integrated Taxonomic Information System on-line... (ac) (46.5 hectares (ha)), home ranges for males averaged 208.3 ac (84.3 ha), and that the species..., therefore, has negative implications for the reproductive success of local populations (Means 2009, p....

  9. 76 FR 46238 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List the Straight...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-02

    ... cycle and slow cycle (Stark et al. 1998, p. 6). Fast cycle species undergo nymphal or egg diapause for..., p. 6). Slow cycle species hatch directly and grow continuously over a 1- to 3- year period and then... riparian vegetation, rocks, or debris (Stewart and Harper 1996, p. 217). The Capniidae family is the...

  10. 76 FR 66255 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to Delist the Coastal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-26

    ... morphological characteristic changes are not representative of genetic differentiation, which differentiation... morphological differences (i.e., plumage coloration, body size) identified by Atwood (1988, pp. iii-vii, 1-74... recognizing morphological distinctiveness to varying degrees within the greater California gnatcatcher...

  11. 76 FR 62375 - Endangered and Threatened Species; 90-Day Finding on Petitions To Delist Coho Salmon Under the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-07

    ...; and (4) is accompanied by the appropriate supporting documentation in the form of bibliographic... Secretary to conduct a status review of the species. The ESA defines an ``endangered species'' as ``any... data available, after conducting a review of the status of the species, and taking into account...

  12. 76 FR 60431 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the American...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-29

    ... by facsimile (413-253-8482). If you use a telecommunications device for the deaf (TDD), please call... temperature (SST), or larvae and glass eel food availability, either directly or indirectly through changes in... Sea. It is hypothesized that there is an abrupt temperature change (referred to as a temperature...

  13. 77 FR 48934 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Bicknell...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-15

    ... the deaf (TDD), please call the Federal Information Relay Service (FIRS) at 800-877- 8339... candidate species in 1996, the species was identified by the North American Bird Conservation Initiative as... Turdidae, which includes all birds related to the robins (Rimmer et al. 2001, p. 2). Rimmer et al....

  14. 77 FR 33143 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Southern...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-05

    ...; fax (303) 236-4005. If you use a telecommunications device for the deaf (TDD), please call the Federal... white-tailed ptarmigan is a small bird in the order Galliformes, family Phasianidae, and the subfamily Tetraoninae, which includes the grouse, or ground-feeding game birds (Hoffman 2006, p. 11; NatureServe 2011,...

  15. 76 FR 23265 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Smooth...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-26

    ... facsimile to 772-562-4288. If you use a telecommunications device for the deaf (TDD), please call the..., Florida, requesting that the smooth- billed ani (Crotophaga ani), a bird, be listed as endangered under... been included on the list of birds of conservation concern in peninsular Florida in 2002 and that...

  16. 77 FR 67784 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List the Heller...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-14

    ... device for the deaf (TDD), please call the Federal Information Relay Service (FIRS) at 800- 877-8339... in temperature, humidity, water quality, and water quantity; and trampling of flora and fauna... collapses or facilitates changes in temperature, humidity, water quality, or water quantity. Therefore,...

  17. 77 FR 47003 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on Petitions To List the Two Spring...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-07

    ... telecommunications device for the deaf (TDD) may call the Federal Information Relay Service (FIRS) at 800-877-8339... many vertebrate and invertebrate wildlife (for example, birds, herptofauna, and other insects), but it... summer; (2) more variable weather patterns and more severe storms; (3) more winter precipitation in...

  18. 75 FR 32728 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List van Rossem's...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-09

    ... telecommunications device for the deaf (TDD) may call the Federal Information Relay Service (FIRS) at 800-877-8339... U.S.C. 2901 et seq.), our Division of Migratory Bird Management included the gull-billed tern (the species as a whole) in the list of Birds of Conservation Concern (USFWS 2002, pp. 1-99; USFWS 2008, pp....

  19. 77 FR 32922 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To Delist or...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-04

    ... altissimum), Lane Mountain milk-vetch (Astragalus jaegerianus), Modoc sucker (Catostomus microps), and Santa..., arroyo toad, Indian Knob mountainbalm, Lane Mountain milk-vetch, or Santa Cruz cypress, contact Diane... Mountain milk-vetch, Modoc sucker, and Santa Cruz cypress from governmental agencies, Native...

  20. 77 FR 71757 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List Phoenix...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-04

    ... Property Owners Association (petitioner), requesting that the single existing grove of Phoenix dactylifera... its parent). Propagation is accomplished by removing offshoots (lateral shoot from the main stem of...'s parent taxon, the date palm; however, its origin is not known with certainty. The sphinx date...

  1. 76 FR 18138 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Spring...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-01

    ...' populations, including genetic isolation; reduction of space for rearing, recruitment, and reproduction..., allows for the potential of colonization of these unoccupied habitat areas when conditions...

  2. 75 FR 42033 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List Pinus albicaulis

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-20

    ... unable to establish and compete for space and light (Tomback et al. 2001, p. 75). In the upper subalpine... flow to the tree's crown and within approximately 2 weeks of colonization, the tree's phloem layer...

  3. 75 FR 38776 - Endangered and Threatened Wildlife and Plants; 90-Day Finding for a Petition to List Puget Sound...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-06

    ... stocks has been effectively severed by 35 years of managing the entire Nooksack River system as a Hatchery Salmon Management Zone. The Skagit River system now forms the northern boundary of a much smaller and isolated viable ESU that now has its southern boundary formed by the Snohomish river system.''...

  4. 77 FR 52301 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the Prince of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-29

    ... ) islands and three of the Barrier Islands (less than 1,236 ac total) (Demboski et al. 1998, p. 1774... islands, including POW (1,428,768 acres (578,202 hectares )), Kosciusko (119,251 ac ), Heceta (46,742 ac...). All of these islands are part of a larger group of islands often referred to as the POW Complex...

  5. 78 FR 10601 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition to List 44 Species of Corals as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-14

    ... cycle and include the order Anthoathecatae (hydrocorals). To date, 134 unique coral taxa have been found... role in the distribution of Alaska coral species, including nutrient flows and productivity, water... directly and indirectly affect cold water corals, yet no empirical studies to date have...

  6. 76 FR 61531 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List 10 Subspecies...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-04

    ... inadequacy of existing regulatory mechanisms; or (e) Other natural or manmade factors affecting its continued... one or more of the five factors described in section 4(a)(1) of the Act: (a) The present or threatened... regulatory mechanisms; or (e) Other natural or manmade factors affecting its continued existence....

  7. 75 FR 48914 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to Delist the Tiger...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-12

    ... mechanisms; or (E) Other natural or manmade factors affecting its continued existence. We must consider these... does not appear, however, that disease or predation are important factors that negatively affect the... important factors negatively affecting the conservation status of the species, the information available...

  8. 75 FR 57426 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To Reclassify the U.S...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-21

    ... and South America. We seek information on: (1) The historical and current status and distribution of..., reptiles, mammals, birds, and arthropods. Fish populations reach high numbers during the wet season,...

  9. 77 FR 3423 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List the `I'iwi as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-24

    ... telecommunications device for the deaf (TTD), please call the Federal Information Relay Service (FIRS) at 800- 877... Ornithologists' Union (AOU 1998, p. 677). The `i'iwi is a medium-sized forest bird (total body length is... gurgling sounds, and they sometimes mimic other birds (Hawaii Audubon Society 2011, p. 97). The...

  10. Toxicological Study No. 75-51-YJ81-93, 4-Amino-2-Nitrotoluene (4A2NT) Oral Approximate Lethal Dose 14-day Range Finding 90-Day Subchronic Feeding Studies in Rats, August 1991-November 1993

    DTIC Science & Technology

    1994-07-01

    NOVEMBER 1993 1. PURPOSE. The oral approximate lethal dose study was conducted todetennine an approximate dosage range at which to begin the 14-day...5000 mg/Kg. The 14-day range fmding study suggested a probable compound related effect in the薘~m (high dose ) exposure groups of both sexes and a...possible compound related effect mIlle 1000 ppm (middle dose ) exposure groups of both sexes. An NOAEL was not established for the 90-day subchronic

  11. The First 90 Days of the New Middle School Principal in a Turnaround School: In-Depth Case Study of the Transition Period (First 90 Days)

    ERIC Educational Resources Information Center

    Baeza, Marco A.

    2010-01-01

    This study analyzed skills, strategies, and theories that new middle school principals used to be successful during their transition period (the first 90 days) in turnaround schools. Based on research on transitions, three research questions guided the study: 1. Do middle school principals in a turnaround school situation find the transition…

  12. 90-Day Inhalation Toxicity Study of FT Fuel

    DTIC Science & Technology

    2011-08-01

    chromosome aberration test and micronucleus assay (Mattie et al., 2011a, 2011b), demonstrated that FT fuel was not mutagenic or genotoxic. The acute...over approximately 90 days, at concentrations of 0, 200, 700, and 2000 mg/m3. In the motor activity test , males exposed to the highest concentration...2 3.1 Test Substance ....................................................................................................................3 3.2

  13. 76 FR 44547 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the Giant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-26

    ...We, the U.S. Fish and Wildlife Service (Service), announce a 12-month finding on a petition to list the giant Palouse earthworm (Driloleirus americanus) as threatened or endangered as petitioned, and to designate critical habitat under the Endangered Species Act of 1973, as amended (Act). After review of all available scientific and commercial information, we find that listing the giant......

  14. 75 FR 49555 - EPA's Denial of the Petitions To Reconsider the Endangerment and Cause or Contribute Findings for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-13

    ...The Environmental Protection Agency (EPA) is denying the petitions to reconsider the Endangerment and Cause or Contribute Findings for Greenhouse Gases under Section 202(a) of the Clean Air Act. The Findings were signed by the Administrator on December 7, 2009. EPA has carefully reviewed all of the petitions and revisited both the scientific record and the Administrator's decision process......

  15. Subacute (90 days) oral toxicity studies of Kombucha tea.

    PubMed

    Vijayaraghavan, R; Singh, M; Rao, P V; Bhattacharya, R; Kumar, P; Sugendran, K; Kumar, O; Pant, S C; Singh, R

    2000-12-01

    Kombucha tea (KT) is a popular health beverage and is used as an alternative therapy. KT is prepared by placing the kombucha culture in solution of tea and sugar and allowing to ferment. The inoculum is a fungus consisting of symbiotic colony of yeast and bacteria. KT is consumed in several countries and is believed to have prophylactic and therapeutic benefits in a wide variety of ailments, viz., intestinal disorders, arthritis, ageing and stimulation of immunological system. Though KT is used in several parts of the world its beneficial effects and adverse effects have not been scientifically evaluated. Since there are no animal toxicological data on KT, subacute oral toxicity study was carried out. Five groups of rats were maintained: (a) control group given tap water orally, (b) KT given 2 ml/kg orally, (c) plain tea (PT) given 2 ml/kg orally, (d) KT given in drinking water, 1% (v/v) and (e) PT given in drinking water, 1% (v/v). The rats were given this treatment daily for a period of 90 days. Weekly records of weight, feed intake, water intake and general behaviour were monitored. There was no significant difference in the growth of the animals as evidenced by the progressive body weight change. The organ to body weight ratio and histological evaluation did not show any toxic signs. The haematological and biochemical variables were within the clinical limits. The study indicates that rats fed KT for 90 days showed no toxic effects.

  16. 76 FR 61855 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the Cactus...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-05

    ...We, the U.S. Fish and Wildlife Service (Service), announce a 12-month finding on a petition to list the cactus ferruginous pygmy-owl (Glaucidium brasilianum cactorum) as threatened or endangered and to designate critical habitat under the Endangered Species Act of 1973, as amended (Act). Additionally, the petition requested that we recognize and list a western subspecies of the cactus......

  17. 77 FR 61375 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on Petitions To List the Mexican...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-09

    ... Fish and Wildlife Service 50 CFR Part 17 Endangered and Threatened Wildlife and Plants; 12-Month Finding on Petitions To List the Mexican Gray Wolf as an Endangered Subspecies or Distinct Population... two petitions to list the Mexican gray wolf (Canis lupus baileyi) (Mexican wolf) as an...

  18. A 90-Day Tenofovir Reservoir Intravaginal Ring for Mucosal HIV Prophylaxis

    PubMed Central

    Johnson, Todd J.; Clark, Meredith R.; Albright, Theodore H.; Nebeker, Joel S.; Tuitupou, Anthony L.; Clark, Justin T.; Fabian, Judit; McCabe, R. Tyler; Chandra, Neelima; Doncel, Gustavo F.; Friend, David R.

    2012-01-01

    A vaginal gel containing the antiretroviral tenofovir (TFV) recently demonstrated 39% protection against HIV infection in women. We designed and evaluated a novel reservoir TFV intravaginal ring (IVR) to potentially improve product effectiveness by providing a more controlled and sustained vaginal dose to maintain cervicovaginal concentrations. Polyurethane tubing of various hydrophilicities was filled with a high-density TFV/glycerol/water semisolid paste and then end-sealed to create IVRs. In vitro, TFV release increased with polyurethane hydrophilicity, with 35 weight percent water-swelling polyurethane IVRs achieving an approximately 10-mg/day release for 90 days with mechanical stiffness similar to that of the commercially available NuvaRing. This design was evaluated in two 90-day in vivo sheep studies for TFV pharmacokinetics and safety. Overall, TFV vaginal tissue, vaginal fluid, and plasma levels were relatively time independent over the 90-day duration at approximately 104 ng/g, 106 ng/g, and 101 ng/ml, respectively, near or exceeding the highest observed concentrations in a TFV 1% gel control group. TFV vaginal fluid concentrations were approximately 1,000-fold greater than levels shown to provide significant protection in women using the TFV 1% gel. There were no toxicological findings following placebo and TFV IVR treatment for 28 or 90 days, although slight to moderate increases in inflammatory infiltrates in the vaginal epithelia were observed in these animals compared to naïve animals. In summary, the controlled release of TFV from this reservoir IVR provided elevated sheep vaginal concentrations for 90 days to merit its further evaluation as an HIV prophylactic. PMID:23006751

  19. Baroreflex Sensitivity Decreases During 90-Day Bed Rest

    NASA Technical Reports Server (NTRS)

    Stenger, M. B.; Arzeno, N. M.; Platts, S. H.

    2008-01-01

    Baroreflex sensitivity (BRS) decreases during spaceflight and simulated spaceflight (head down bed rest [BR]). However, previous studies have only examined BRS in response to a limited blood pressure (BP) range or to a single sudden change in BP. PURPOSE: The purpose of this study was to examine BRS during 90 days of 6deg head-down tilt BR over a broad range of BP perturbations. METHODS: Nineteen normal volunteers (12M, 7F) were tested one day before BR, and then near BR days 30, 60 and 90. BP was pharmacologically altered by continuous infusions of phenylephrine (PE) and sodium nitroprusside (SNP). Electrocardiogram and continuous BP were collected during 10 min of normal saline (NS), followed by increasing concentrations of PE (10 min each of 0.4, 0.8 and 1.6 micro-g/kg/min). After a 20 min break, NS was infused again for 10 min, followed by increasing concentrations of SNP (10 min each of 0.4, 0.8, 1.2 micro-g/kg/min). Baroreceptor sensitivity was measured as the slope of a sequence of 3 or more beats in which the systolic BP and following R-R interval (RR) both increased or decreased. Spectral heart rate variability (HRV) and mean RR were analyzed using data from only the NS infusions. Two-way repeated-measures analysis of variance was performed to examine the effects of BR and gender. RESULTS: RR decreased (p<0.001) from pre- BR across BR days. High frequency in normalized units, a measure of parasympathetic activity, decreased with BR (p=0.027) and was lower (p=0.046) in men (0.39+/-0.02, mean+/-SEM) than women (0.48+/-0.02). The spontaneous baroreflex slope, our measure of BRS, increased with PE and decreased with SNP across BR (p<0.001). The percentage decrease in BRS from pre- to post-BR appeared to be larger in women (43.6+/-7.0%) than in men (31.3+/-3.9%, p=0.06). CONCLUSION: Parasympathetic activity and baroreflex sensitivity decrease during 90 days of BR, and BRS tends to diminish more in women than in men.

  20. 49 CFR 24.402 - Replacement housing payment for 90-day occupants.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Replacement housing payment for 90-day occupants... Payments § 24.402 Replacement housing payment for 90-day occupants. (a) Eligibility. A tenant or owner... occupied the displacement dwelling for at least 90 days immediately prior to the initiation of...

  1. 49 CFR 24.402 - Replacement housing payment for 90-day occupants.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false Replacement housing payment for 90-day occupants... Payments § 24.402 Replacement housing payment for 90-day occupants. (a) Eligibility. A tenant or owner... occupied the displacement dwelling for at least 90 days immediately prior to the initiation of...

  2. 49 CFR 24.402 - Replacement housing payment for 90-day occupants.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false Replacement housing payment for 90-day occupants... Payments § 24.402 Replacement housing payment for 90-day occupants. (a) Eligibility. A tenant or owner... occupied the displacement dwelling for at least 90 days immediately prior to the initiation of...

  3. 29 CFR 2590.715-2708 - Prohibition on waiting periods that exceed 90 days.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 9 2014-07-01 2014-07-01 false Prohibition on waiting periods that exceed 90 days. 2590... PLANS Other Requirements § 2590.715-2708 Prohibition on waiting periods that exceed 90 days. (a) General... not apply any waiting period that exceeds 90 days, in accordance with the rules of this section....

  4. 49 CFR 24.503 - Replacement housing payment for 90-day mobile home occupants.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false Replacement housing payment for 90-day mobile home... Replacement housing payment for 90-day mobile home occupants. A displaced tenant or owner-occupant of a mobile... 90 days immediately prior to the initiation of negotiations; (b) The person meets the other...

  5. 49 CFR 24.402 - Replacement housing payment for 90-day occupants.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Replacement housing payment for 90-day occupants... Payments § 24.402 Replacement housing payment for 90-day occupants. (a) Eligibility. A tenant or owner... occupied the displacement dwelling for at least 90 days immediately prior to the initiation of...

  6. 49 CFR 24.503 - Replacement housing payment for 90-day mobile home occupants.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false Replacement housing payment for 90-day mobile home... Replacement housing payment for 90-day mobile home occupants. A displaced tenant or owner-occupant of a mobile... 90 days immediately prior to the initiation of negotiations; (b) The person meets the other...

  7. 49 CFR 24.402 - Replacement housing payment for 90-day occupants.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Replacement housing payment for 90-day occupants... Payments § 24.402 Replacement housing payment for 90-day occupants. (a) Eligibility. A tenant or owner... occupied the displacement dwelling for at least 90 days immediately prior to the initiation of...

  8. 49 CFR 24.503 - Replacement housing payment for 90-day mobile home occupants.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Replacement housing payment for 90-day mobile home... Replacement housing payment for 90-day mobile home occupants. A displaced tenant or owner-occupant of a mobile... 90 days immediately prior to the initiation of negotiations; (b) The person meets the other...

  9. 50 CFR 424.14 - Petitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... COMMERCE); ENDANGERED SPECIES COMMITTEE REGULATIONS SUBCHAPTER A LISTING ENDANGERED AND THREATENED SPECIES... a petition within 30 days. (b) Petitions to list, delist, or reclassify species. (1) To the maximum extent practicable, within 90 days of receiving a petition to list, delist, or reclassify a species,...

  10. 50 CFR 424.14 - Petitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... COMMERCE); ENDANGERED SPECIES COMMITTEE REGULATIONS SUBCHAPTER A LISTING ENDANGERED AND THREATENED SPECIES... a petition within 30 days. (b) Petitions to list, delist, or reclassify species. (1) To the maximum extent practicable, within 90 days of receiving a petition to list, delist, or reclassify a species,...

  11. 50 CFR 424.14 - Petitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... COMMERCE); ENDANGERED SPECIES COMMITTEE REGULATIONS SUBCHAPTER A LISTING ENDANGERED AND THREATENED SPECIES... a petition within 30 days. (b) Petitions to list, delist, or reclassify species. (1) To the maximum extent practicable, within 90 days of receiving a petition to list, delist, or reclassify a species,...

  12. 50 CFR 424.14 - Petitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... COMMERCE); ENDANGERED SPECIES COMMITTEE REGULATIONS SUBCHAPTER A LISTING ENDANGERED AND THREATENED SPECIES... a petition within 30 days. (b) Petitions to list, delist, or reclassify species. (1) To the maximum extent practicable, within 90 days of receiving a petition to list, delist, or reclassify a species,...

  13. The 90-day oral toxicity of d-psicose in male Wistar rats.

    PubMed

    Matsuo, Tatsuhiro; Ishii, Reika; Shirai, Yoko

    2012-03-01

    d-Psicose is a rare sugar present in small quantities in natural products. In a previous study, we showed that d-psicose suppresses increase in plasma glucose and reduces body fat accumulation in rats. Based on acute toxicity testing in rats, d-psicose is classified as an ordinary substance (LD(50) = 16 g/kg). Elucidating the effects of sub-chronic feeding of d-psicose in rats is essential before it can be utilized as a physiologically functional food. In this study, male Wistar rats (3 weeks old) were fed diets containing 3% d-psicose or sucrose for 90 days. The body weight gain and intra-abdominal adipose tissue weight did not differ between the sucrose and the d-psicose groups. The weights of the liver and kidneys were significantly higher in the d-psicose group than in the sucrose group. However, no gross pathological findings were evident at dietary doses of 3% d-psicose or were correlated with hypertrophy of the liver and kidney. In a clinical chemistry analysis, the erythrocyte and leukocyte courts were significantly higher in the d-psicose group, but that was not considered to be toxicologically significant. Therefore, the present study found no adverse effects of d-psicose in rats fed a diet containing 3% d-psicosefor 90 days.

  14. Safety assessment of vitacoxib: Acute and 90-day sub-chronic oral toxicity studies.

    PubMed

    Wang, Jianzhong; Sun, Feifei; Tang, Shusheng; Zhang, Suxia; Lv, Pengyue; Li, Jing; Cao, Xingyuan

    2017-02-24

    Vitacoxib, is a newly developed coxibs NSAID (selective inhibitors of cyclooxygenase-2). To date, no experimental data have been published concerning its safety for use as an additive in the human diet. In the present study, we assessed the acute and sub-chronic toxicity of vitacoxib administered by gavage. The acute toxicity tests in Sprague Dawley (SD) rats and ICR mice demonstrated that vitacoxib at a dose of 5000 mg/kg BW failed to alter any of the parameters studied. In the 90-day sub-chronic toxicity test, vitacoxib was administered to SD rats at the doses of 0 (control), 5, 10, 20, 30, and 60 mg/kg BW. The results demonstrated that there were no significant differences for most indexes of sub-chronic toxicity throughout the experiment at the dose of 5-20 mg/kg BW, indicating no apparent dose-dependent. However, there were significant histopathology changes in the liver and kidney, and alterations in some biochemical parameters in the 60 mg/kg BW group. Based on these findings, the gavage LD50 was determined to be > 5000 mg/kg in SD rats and ICR mice, and the 90-day gavage no-observed-adverse-effect level (NOAEL) of vitacoxib was considered to be 20 mg/kg BW under the present study conditions.

  15. A subchronic 90-day oral toxicity study of Origanum vulgare essential oil in rats.

    PubMed

    Llana-Ruiz-Cabello, M; Maisanaba, S; Puerto, M; Pichardo, S; Jos, A; Moyano, R; Cameán, A M

    2017-03-01

    Oregano essential oil (Origanum vulgare L. virens) (OEO) is being used in the food industry due to its useful properties to develop new active packaging systems. In this concern, the safety assessment of this natural extract is of great interest before being commercialized. The European Food Safety Authority requests different in vivo assays to ensure the safety of food contact materials. One of these studies is a 90 days repeated-dose oral assay in rodents. In the present work, 40 male and 40 female Wistar rats were orally exposed to 50, 100 and 200 mg/kg body weight (b.w.) OEO during 90 days following the OECD guideline 408. Data revealed no mortality and no treatment-related adverse effects of the OEO in food/water consumption, body weight, haematology, biochemistry, necropsy, organ weight and histopathology. These findings suggest that the oral no-observed-adverse-effect level (NOAEL) of this OEO is 200 mg/kg b.w. in Wistar rats, the highest dose tested. In conclusion, the use of this OEO in food packaging appears to be safe based on the lack of toxicity during the subchronic study at doses 330-fold higher than those expected to be in contact consumers in the worst scenario of exposure.

  16. 76 FR 12667 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the Mt...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-08

    ... Finding on a Petition To List the Mt. Charleston Blue Butterfly as Endangered or Threatened AGENCY: Fish... butterfly (Plebejus shasta charlestonensis) (formerly in genus Icaricia) as endangered or threatened under... commercial information, we find that listing the Mt. Charleston blue butterfly is warranted....

  17. 77 FR 52650 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the Platte...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-30

    ...We, the U.S. Fish and Wildlife Service (Service), announce a 12-month finding on a petition to list the Platte River caddisfly (Ironoquia plattensis) as an endangered or threatened species and to designate critical habitat under the Endangered Species Act of 1973, as amended. After review of all available scientific and commercial information, we find that listing the Platte River caddisfly as......

  18. 76 FR 42631 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List Pinus...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-19

    ...We, the U.S. Fish and Wildlife Service (Service), announce a 12-month finding on a petition to list Pinus albicaulis (whitebark pine) as threatened or endangered and to designate critical habitat under the Endangered Species Act of 1973, as amended (Act). After review of all available scientific and commercial information, we find that listing P. albicaulis as threatened or endangered is......

  19. 76 FR 62213 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the Mohave...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-06

    ...We, the U.S. Fish and Wildlife Service (Service), announce a 12-month finding on a petition to list the Mohave ground squirrel (Spermophilus mohavensis) as endangered or threatened under the Endangered Species Act of 1973, as amended (Act). After review of the best available scientific and commercial information, we find that listing the Mohave ground squirrel is not warranted at this time.......

  20. 75 FR 57720 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition to List Agave...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-22

    ...We, the Fish and Wildlife Service (Service), announce a 12- month finding on a petition to list the plant Agave eggersiana (no common name) as endangered under the Endangered Species Act of 1973, as amended (Act). After review of all available scientific and commercial information, we find that listing A. eggersiana is warranted. Currently, however, listing A. eggersiana is precluded by higher......

  1. 75 FR 78029 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the North...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-14

    ...We, the U.S. Fish and Wildlife Service (Service), announce a 12-month finding on a petition to list the North American wolverine (Gulo gulo luscus) as an endangered or threatened species under the Endangered Species Act of 1973, as amended (Act). After review of all available scientific and commercial information, we find that the North American wolverine occurring in the contiguous United......

  2. 75 FR 67925 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition to List Cirsium...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-04

    ...We, the U.S. Fish and Wildlife Service, announce a 12-month finding on a petition to list Cirsium wrightii (Wright's marsh thistle) as endangered or threatened and to designate critical habitat under the Endangered Species Act of 1973, as amended. After review of all available scientific and commercial information, we find that listing C. wrightii as endangered or threatened throughout its......

  3. 75 FR 56028 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition to List Sprague's...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-15

    ...We, the U.S. Fish and Wildlife Service (Service), announce a 12-month finding on a petition to list the Sprague's pipit (Anthus spragueii) as endangered or threatened and to designate critical habitat under the Endangered Species Act of 1973, as amended (ESA). After review of all available scientific and commercial information, we find that listing the Sprague's pipit as endangered or......

  4. 75 FR 78093 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the Sonoran...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-14

    ...We, the U.S. Fish and Wildlife Service, announce a 12-month finding on a petition to list the Sonoran population of the desert tortoise (Gopherus agassizii) as endangered or threatened and to designate critical habitat under the Endangered Species Act of 1973, as amended (Act). After review of all available scientific and commercial information, we find that listing the Sonoran population of......

  5. 75 FR 30757 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition to Delist Cirsium...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-02

    ...We, the U.S. Fish and Wildlife Service, announce a 12-month finding on a petition to remove Cirsium vinaceum (Sacramento Mountains thistle) from the Federal List of Threatened and Endangered Plants under the Endangered Species Act. After reviewing the best scientific and commercial information available, we find that delisting C. vinaceum is not warranted. However, we ask the public to submit......

  6. 78 FR 61763 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List Kittlitz's...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-03

    ...We, the U.S. Fish and Wildlife Service (Service), announce a 12-month finding on a petition to list the Kittlitz's murrelet (Brachyramphus brevirostris) as an endangered or threatened species and to designate critical habitat under the Endangered Species Act of 1973, as amended (Act). After a review of the best available scientific and commercial information, we find that listing the......

  7. 75 FR 13909 - Endangered and Threatened Wildlife and Plants; 12-Month Findings for Petitions to List the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-23

    ...We, the U.S. Fish and Wildlife Service (Service), announce three 12-month findings on petitions to list three entities of the greater sage-grouse (Centrocercus urophasianus) as threatened or endangered under the Endangered Species Act of 1973, as amended (Act). We find that listing the greater sage-grouse (rangewide) is warranted, but precluded by higher priority listing actions. We will......

  8. 76 FR 7633 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition to List the Pacific...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-10

    ...We, the U.S. Fish and Wildlife Service, announce a 12-month finding on a petition to list the Pacific walrus (Odobenus rosmarus divergens) as endangered or threatened and to designate critical habitat under the Endangered Species Act of 1973, as amended. After review of all the available scientific and commercial information, we find that listing the Pacific walrus as endangered or threatened......

  9. 77 FR 57921 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List 14 Aquatic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-18

    ...We, the U.S. Fish and Wildlife Service (Service), announce a 12-month finding on a petition to list the basalt juga (Juga new species (n. sp.) 2), canary duskysnail (Colligyrus convexus), cinnamon juga (Juga n. sp. 3), Columbia duskysnail (Colligyrus n. sp. 1), Fredenburg pebblesnail (Fluminicola n. sp. 11), Goose Valley pebblesnail (Fluminicola anserinus), Hat Creek pebblesnail (Fluminicola......

  10. 75 FR 19592 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition to List the Wyoming...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-15

    ... habitat under the Endangered Species Act of 1973, as amended. After review of all available scientific and... Wildlife and Plants that presents substantial scientific or commercial information indicating that listing... published our finding that the petition to list the Wyoming pocket gopher presented substantial...

  11. 77 FR 19597 - Listing Endangered and Threatened Species; 12-Month Finding on a Petition To List Chinook Salmon...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-02

    ...We, NMFS, announce a 12-month finding on a petition to list the Chinook salmon (Oncorhynchus tshawytscha) in the Upper Klamath and Trinity Rivers Basin (UKTR) as threatened or endangered and designate critical habitat under the Endangered Species Act (ESA). We have reviewed the status of the UKTR Chinook salmon Evolutionarily Significant Unit (ESU) and considered the best scientific and......

  12. 77 FR 27386 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-10

    ... Fish and Wildlife Service 50 CFR Part 17 Endangered and Threatened Wildlife and Plants; 12-Month... Wildlife and Plants. Upon publication of this 12-month petition finding, we will add the Arapahoe snowfly... to revise the Federal Lists of Threatened and Endangered Wildlife and Plants that...

  13. 25 CFR 900.17 - Can the statutory 90-day period be extended?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false Can the statutory 90-day period be extended? 900.17... ASSISTANCE ACT Review and Approval of Contract Proposals § 900.17 Can the statutory 90-day period be extended...-day deadline applies....

  14. 25 CFR 900.17 - Can the statutory 90-day period be extended?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Can the statutory 90-day period be extended? 900.17... ASSISTANCE ACT Review and Approval of Contract Proposals § 900.17 Can the statutory 90-day period be extended...-day deadline applies....

  15. 25 CFR 900.17 - Can the statutory 90-day period be extended?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 2 2014-04-01 2014-04-01 false Can the statutory 90-day period be extended? 900.17... ASSISTANCE ACT Review and Approval of Contract Proposals § 900.17 Can the statutory 90-day period be extended...-day deadline applies....

  16. 25 CFR 900.17 - Can the statutory 90-day period be extended?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 2 2013-04-01 2013-04-01 false Can the statutory 90-day period be extended? 900.17... ASSISTANCE ACT Review and Approval of Contract Proposals § 900.17 Can the statutory 90-day period be extended...-day deadline applies....

  17. 49 CFR 24.503 - Replacement housing payment for 90-day mobile home occupants.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Replacement housing payment for 90-day mobile home... ASSISTANCE AND REAL PROPERTY ACQUISITION FOR FEDERAL AND FEDERALLY-ASSISTED PROGRAMS Mobile Homes § 24.503 Replacement housing payment for 90-day mobile home occupants. A displaced tenant or owner-occupant of a...

  18. A 90 day chronic toxicity study of Nigerian herbal preparation DAS-77 in rats

    PubMed Central

    2012-01-01

    Background The herbal preparation DAS-77, used for the treatment of various ailments in Nigeria, contains the milled bark of Mangifera indica L. and root of Carica papaya L. Toxicological assessment of the preparation was carried out in this study. Methods In the acute toxicity study, DAS-77 was administered to mice p.o. up to 20 g/kg in divided doses and i.p. at 250–3000 mg/kg. Mortality within 24 h was recorded. In the chronic toxicity study, rats were treated p.o. for 90 days at doses of 80, 400 (therapeutic dose, TD) and 2000 mg/kg. By 90 days, animals were sacrificed and blood samples collected for hematological and biochemical analysis. Organs were harvested for weight determination, antioxidants and histopathological assessments. Results DAS-77 did not produce any lethality administered p.o. up to 20 g/kg in divided doses but the i.p. LD50 was 1122.0 mg/kg. At TD, DAS-77 produced significant (p < 0.05) reductions in body weight, food intake and K+, and increases in ovary weight, neutrophils and HDL, which were reversible. Histopathological presentations were generally normal. Effects at the other doses were comparable to those at TD except for reversible increases in antioxidants in the liver, kidney and testes, and sperm abnormality, and reductions in liver enzymes, sperm motility and count. Conclusions Findings in this study revealed that DAS-77 is relatively safe with the potential for enhancing in vivo antioxidant activity. However, possibly reversible side-effects include electrolyte imbalance and sterility in males. PMID:22892317

  19. 76 FR 61895 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-05

    ...We, the U.S. Fish and Wildlife Service, announce a 12-month finding on a petition to list the northern leopard frog (Lithobates (=Rana) pipiens) under the Endangered Species Act of 1973, as amended (Act). After review of the best scientific and commercial information, we find that listing the northern leopard frog is not warranted at this time. However, we ask the public to submit to us any......

  20. 77 FR 19755 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition to List the San...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-02

    ...We, the U.S. Fish and Wildlife Service (Service), announce a 12-month finding on a petition to list the San Francisco Bay-Delta distinct population segment (Bay Delta DPS) of longfin smelt as endangered or threatened and to designate critical habitat under the Endangered Species Act of 1973, as amended (Act). After review of the best available scientific and commercial information, we find......

  1. 76 FR 45129 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the Gopher...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-27

    ...We, the U.S. Fish and Wildlife Service (Service), announce a 12-month finding on a petition to list the gopher tortoise (Gopherus polyphemus) in the eastern portion of its range (east of the Mobile and Tombigbee Rivers) as threatened and to designate critical habitat under the Endangered Species Act of 1973, as amended. In this finding, we also evaluate whether the status of the gopher......

  2. 75 FR 17352 - Endangered and Threatened Wildlife and Plants; 12-month Finding on a Petition To List the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-06

    ...We, the U.S. Fish and Wildlife Service (Service), announce a 12-month finding on a petition to list the mountain whitefish (Prosopium williamsoni) in the Big Lost River, Idaho, as endangered or threatened under the Endangered Species Act of 1973, as amended. After review of all available scientific and commercial information, we find that the mountain whitefish in the Big Lost River does not......

  3. 76 FR 63479 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List Two South...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-12

    ...We, the U.S. Fish and Wildlife Service, announce a status review (12-month finding) on a petition to list the blue-headed macaw (Primolius couloni) and grey-cheeked parakeet (Brotogeris pyrrhoptera) as threatened or endangered under the Endangered Species Act of 1973, as amended (Act). After review of all available scientific and commercial information, we find that listing the blue-headed......

  4. 75 FR 6437 - Endangered and Threatened Wildlife and Plants; 12-month Finding on a Petition to List the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-09

    ...We, the U.S. Fish and Wildlife Service (Service), announce a 12-month finding on a petition to list the American pika (Ochotona princeps) as threatened or endangered under the Endangered Species Act of 1973, as amended. After review of all available scientific and commercial information, we find that listing the American pika, at the species level or any of the five recognized subspecies (O.......

  5. 19 CFR Annex Viii-A to Part 351 - Schedule for 90-Day Sunset Reviews

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 3 2014-04-01 2014-04-01 false Schedule for 90-Day Sunset Reviews VIII Annex VIII... AND COUNTERVAILING DUTIES Pt. 351, Annex VIII-A Annex VIII-A to Part 351—Schedule for 90-Day Sunset Reviews Day 1 Event Regulation 0 Initiation § 351.218(c) 15 Filing of Notice of Intent to Participate...

  6. 19 CFR Annex Viii-A to Part 351 - Schedule for 90-Day Sunset Reviews

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 3 2012-04-01 2012-04-01 false Schedule for 90-Day Sunset Reviews VIII Annex VIII... AND COUNTERVAILING DUTIES Pt. 351, Annex VIII-A Annex VIII-A to Part 351—Schedule for 90-Day Sunset Reviews Day 1 Event Regulation 0 Initiation § 351.218(c) 15 Filing of Notice of Intent to Participate...

  7. 19 CFR Annex Viii-A to Part 351 - Schedule for 90-Day Sunset Reviews

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 3 2013-04-01 2013-04-01 false Schedule for 90-Day Sunset Reviews VIII Annex VIII... AND COUNTERVAILING DUTIES Pt. 351, Annex VIII-A Annex VIII-A to Part 351—Schedule for 90-Day Sunset Reviews Day 1 Event Regulation 0 Initiation § 351.218(c) 15 Filing of Notice of Intent to Participate...

  8. 21 CFR 60.34 - FDA action on petitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false FDA action on petitions. 60.34 Section 60.34 Food... RESTORATION Due Diligence Petitions § 60.34 FDA action on petitions. (a) Within 90 days after FDA receives a... during the regulatory review period. FDA will publish its due diligence determination in the...

  9. 76 FR 55169 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on Five Petitions To List Seven...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-06

    ...We, the U.S. Fish and Wildlife Service (Service), announce a 12-month finding on five petitions to list seven species of Hawaiian yellow-faced bees (Hylaeus anthracinus, H. assimulans, H. facilis, H. hilaris, H. kuakea, H. longiceps, and H. mana) as endangered and to designate critical habitat under the Endangered Species Act of 1973, as amended (Act). After review of all available scientific......

  10. 77 FR 29077 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To Downlist Three...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-16

    ...We, the U.S. Fish and Wildlife Service, announce our 12-month findings on a petition to reclassify San Clemente Island lotus, and San Clemente Island paintbrush under the Endangered Species Act are warranted and we propose to change the status of these two species from endangered to threatened. We also propose to correct the scientific and common names of San Clement Island lotus. We are also......

  11. A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine

    PubMed Central

    Hirka, Gábor; Glávits, Róbert; Palmer, Philip A.; Endres, John R.; Pasics Szakonyiné, Ilona

    2016-01-01

    A 90-day repeated-dose oral toxicological evaluation was conducted according to GLP and OECD guidelines on the methylurate purine alkaloid theacrine, which is found naturally in certain plants. Four groups of Hsd.Brl.Han Wistar rats (ten/sex/group) were administered theacrine by gavage doses of 0 (vehicle only), 180, 300, and 375 mg/kg bw/day. Two females and one male in the 300 and 375 mg/kg bw/day groups, respectively, died during the study. Histological examination revealed centrilobular hepatocellular necrosis as the probable cause of death. In 375 mg/kg bw/day males, slight reductions in body weight development, food consumption, and feed efficiency, decreased weight of the testes and epididymides and decreased intensity of spermatogenesis in the testes, lack or decreased amount of mature spermatozoa in the epididymides, and decreased amount of prostatic secretions were detected at the end of the three months. At 300 mg/kg bw/day, slight decreases in the weights of the testes and epididymides, along with decreased intensity of spermatogenesis in the testes, and lack or decreased amount of mature spermatozoa in the epididymides were detected in male animals. The NOAEL was considered to be 180 mg/kg bw/day, as at this dose there were no toxicologically relevant treatment-related findings in male or female animals. PMID:27635133

  12. A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine.

    PubMed

    Clewell, Amy; Hirka, Gábor; Glávits, Róbert; Palmer, Philip A; Endres, John R; Murbach, Timothy S; Marx, Tennille; Pasics Szakonyiné, Ilona

    2016-01-01

    A 90-day repeated-dose oral toxicological evaluation was conducted according to GLP and OECD guidelines on the methylurate purine alkaloid theacrine, which is found naturally in certain plants. Four groups of Hsd.Brl.Han Wistar rats (ten/sex/group) were administered theacrine by gavage doses of 0 (vehicle only), 180, 300, and 375 mg/kg bw/day. Two females and one male in the 300 and 375 mg/kg bw/day groups, respectively, died during the study. Histological examination revealed centrilobular hepatocellular necrosis as the probable cause of death. In 375 mg/kg bw/day males, slight reductions in body weight development, food consumption, and feed efficiency, decreased weight of the testes and epididymides and decreased intensity of spermatogenesis in the testes, lack or decreased amount of mature spermatozoa in the epididymides, and decreased amount of prostatic secretions were detected at the end of the three months. At 300 mg/kg bw/day, slight decreases in the weights of the testes and epididymides, along with decreased intensity of spermatogenesis in the testes, and lack or decreased amount of mature spermatozoa in the epididymides were detected in male animals. The NOAEL was considered to be 180 mg/kg bw/day, as at this dose there were no toxicologically relevant treatment-related findings in male or female animals.

  13. 90-day postoperative mortality is a legitimate measure of hepatopancreatobiliary surgical quality

    PubMed Central

    Mise, Yoshihiro; Vauthey, Jean-Nicolas; Zimmitti, Giuseppe; Parker, Nathan H.; Conrad, Claudius; Aloia, Thomas A.; Lee, Jeffery E.; Fleming, Jason B.; Katz, Matthew H. G.

    2015-01-01

    Objective To investigate the legitimacy of 90-day mortality as a measure of hepatopancreatobiliary quality. Summary Background Data The 90-day mortality rate has been increasingly but not universally reported after hepatopancreatobiliary surgery. The legitimacy of this definition as a measure of surgical quality has not been evaluated. Methods We retrospectively reviewed the causes of all deaths that occurred within 365 postoperative days in patients undergoing hepatectomy (n = 2811) and/or pancreatectomy (n = 1092) from January 1997 through December 2012. The rates of surgery-related, disease-related, and overall mortality within 30 days, within 30 days or during the index hospitalization, within 90 days, and within 180 days following surgery were calculated. Results Seventy-nine (3%) surgery-related deaths and 92 (3%) disease-related deaths occurred within 365 days after hepatectomy. Twenty (2%) surgery-related deaths and 112 (10%) disease-related deaths occurred within 365 days after pancreatectomy. The overall mortality rates at 99 day and 118 days optimally reflected surgery-related mortality following hepatobiliary and pancreatic operations, respectively. The 90-day overall mortality rate was a less sensitive but equivalently specific measure of surgery-related death. Conclusions and Relevance The 99-day and 118-day definitions of postoperative mortality optimally reflected surgery-related mortality following hepatobiliary and pancreatic operations, respectively. However, among commonly reported metrics, the 90-day overall mortality rate represents a legitimate measure of surgical quality. PMID:25590497

  14. 78 FR 12459 - State Implementation Plans: Response to Petition for Rulemaking; Findings of Substantial...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-22

    ... request in the Petition to rescind its policy interpreting the Clean Air Act (CAA) to allow states to have appropriately drawn state implementation plan (SIP) provisions that provide affirmative defenses to monetary... action reflects the EPA's current SSM Policy for SIPs. DATES: Comments. Comments must be received on...

  15. 76 FR 25149 - Endangered and Threatened Wildlife and Plants; Annual Notice of Findings on Resubmitted Petitions...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-03

    ... telecommunications device for the deaf (TDD) may call the Federal Information Relay Service (FIRS) at 800-877-8339... submitted to the U.S. Fish and Wildlife Service (Service) to list a number of foreign bird and butterfly species as endangered or threatened under the Act. We received petitions to list foreign bird species...

  16. 78 FR 24603 - Endangered and Threatened Wildlife and Plants; Annual Notice of Findings on Resubmitted Petitions...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-25

    ... use a telecommunications device for the deaf (TDD), call the Federal Information Relay Service (FIRS.... Fish and Wildlife Service (Service) to list a number of foreign bird and butterfly species as endangered or threatened under the Act. We received petitions to list foreign bird species on November...

  17. Zinc oxide nanoparticles: a 90-day repeated-dose dermal toxicity study in rats

    PubMed Central

    Ryu, Hwa Jung; Seo, Mu Yeb; Jung, Sung Kyu; Maeng, Eun Ho; Lee, Seung-Young; Jang, Dong-Hyouk; Lee, Taek-Jin; Jo, Ki-Yeon; Kim, Yu-Ri; Cho, Kyu-Bong; Kim, Meyoung-Kon; Lee, Beom Jun; Son, Sang Wook

    2014-01-01

    Zinc oxide (ZnO) works as a long-lasting, broad-spectrum physical sunblock, and can prevent skin cancer, sunburn, and photoaging. Nanosized ZnO particles are used often in sunscreens due to consumer preference over larger sizes, which appear opaque when dermally applied. Although the US Food and Drug Administration approved the use of nanoparticles (NPs) in sunscreens in 1999, there are ongoing safety concerns. The aim of this study was to evaluate the subchronic toxicity of ZnO NPs after dermal application according to the Organization for Economic Cooperation and Development Test Guidelines 411 using Good Laboratory Practice. Sprague Dawley rats were randomly divided into eight (one control, one vehicle control, three experimental, and three recovery) groups. Different concentrations of ZnO NPs were dermally applied to the rats in the experimental groups for 90 days. Clinical observations as well as weight and food consumption were measured and recorded daily. Hematology and biochemistry parameters were determined. Gross pathologic and histopathologic examinations were performed on selected tissues from all animals. Analyses of tissue were undertaken to determine target organ tissue distribution. There was no increased mortality in the experimental group. Although there was dose-dependent irritation at the site of application, there were no abnormal findings related to ZnO NPs in other organs. Increased concentrations of ZnO in the liver, small intestine, large intestine, and feces were thought to result from oral ingestion of ZnO NPs via licking. Penetration of ZnO NPs through the skin seemed to be limited via the dermal route. This study demonstrates that there was no observed adverse effect of ZnO NPs up to 1,000 mg/kg body weight when they are applied dermally. PMID:25565832

  18. 40 CFR 799.9310 - TSCA 90-day oral toxicity in rodents.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... target organs, body weight changes, effects on mortality and any other general or specific toxic effects... REQUIREMENTS Health Effects Test Guidelines § 799.9310 TSCA 90-day oral toxicity in rodents. (a) Scope. This... no-observed-effects level (NOEL) and toxic effects associated with continuous or repeated exposure...

  19. 40 CFR 799.9310 - TSCA 90-day oral toxicity in rodents.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... target organs, body weight changes, effects on mortality and any other general or specific toxic effects... REQUIREMENTS Health Effects Test Guidelines § 799.9310 TSCA 90-day oral toxicity in rodents. (a) Scope. This... no-observed-effects level (NOEL) and toxic effects associated with continuous or repeated exposure...

  20. 26 CFR 54.9815-2708 - Prohibition on waiting periods that exceed 90 days.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... days. 54.9815-2708 Section 54.9815-2708 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... on waiting periods that exceed 90 days. (a) General rule. A group health plan, and a health insurance issuer offering group health insurance coverage, must not apply any waiting period that exceeds 90...

  1. Implications of the 90-day episode definition used for the Comprehensive Care for Joint Replacement model

    PubMed Central

    Ellimoottil, Chad; Ryan, Andrew M.; Hou, Hechuan; Dupree, James M.; Hallstrom, Brian; Miller, David C.

    2017-01-01

    Importance Under the Comprehensive Care for Joint Replacement (CJR) model, hospitals are held accountable for nearly all Medicare payments that occur during the initial hospitalization through 90-days post-discharge (i.e., episode of care). It is unknown whether unrelated expenditures resulting from this “broad” episode definition will impact participating hospital’s average 90-day episode payments. Objective To compare the CJR program’s broad episode definition to a clinically-narrow episode definition Design We identified Medicare claims for patients in Michigan who underwent joint replacement from 2011 through 2013. Using specifications from the CJR model and the clinically-narrow Hospital Compare payment measure, we constructed episodes of care and calculated 90-day episode payments. We then compared hospitals’ average 90-day episode payments using the two episode definitions and fit linear regression models to understand whether payment differences were associated with specific hospital characteristics (average CMS-HCC risk score, rural hospital status, joint replacement volume, percentage of Medicaid discharges, teaching hospital status, number of beds, percentage of joint replacements performed on African American patients and median income of the hospital’s county). Setting All Michigan hospitals located in metropolitan statistical areas Participants Medicare beneficiaries Main Outcome and Measure(s) The correlation and difference between average 90-day episode payments using the broad CJR model episode definition and the clinically-narrow Hospital Compare episode definition. Results We identified 23,251 joint replacement episodes. 90-day episode payments using the broad CJR episode definition ranged from $17,349 to $29,465 (mean: $22,122, standard deviation: $2,600). Episode payments were slightly lower (mean: $21,670) when the Hospital Compare episode definition was used. Both methods were strongly correlated (r=0.99, p<0.001). The average

  2. Safety assessment of meat from transgenic cattle by 90-day feeding study in rats.

    PubMed

    Liu, Shan; Li, Chen-Xi; Feng, Xiao-Lian; Wang, Hui-Ling; Liu, Hai-Bo; Zhi, Yuan; Geng, Gui-Ying; Zhao, Jie; Xu, Hai-Bin

    2013-07-01

    The study was carried out to evaluate the subchronic toxicity of meat derived from human lactoferrin gene-modified cattle in male and female Wistar rats. Rats were fed 5% or 10% transgenic meat diet, 5% or 10% conventional meat diet, or AIN93G diet for 90 days. During the study, body weight and food consumption were weighed weekly and clinical observations were conducted daily. At the end of the study, urinary examination, hematology and blood biochemistry examination, macroscopic and microscopic examinations were performed. There were no biologically significant differences in these factors between the rat groups fed transgenic meat diet and conventional meat diet. Therefore, the present 90-day rodent feeding study suggests that meat derived from the transgenic cattle is equivalent to meat from conventional cattle in use as dietary supplements.

  3. Preoperative risk score predicting 90-day mortality after liver resection in a population-based study.

    PubMed

    Chang, Chun-Ming; Yin, Wen-Yao; Su, Yu-Chieh; Wei, Chang-Kao; Lee, Cheng-Hung; Juang, Shiun-Yang; Chen, Yi-Ting; Chen, Jin-Cherng; Lee, Ching-Chih

    2014-09-01

    The impact of important preexisting comorbidities, such as liver and renal disease, on the outcome of liver resection remains unclear. Identification of patients at risk of mortality will aid in improving preoperative preparations. The purpose of this study is to develop and validate a population-based score based on available preoperative and predictable parameters predicting 90-day mortality after liver resection using data from a hepatitis endemic country.We identified 13,159 patients who underwent liver resection between 2002 and 2006 in the Taiwan National Health Insurance Research Database. In a randomly selected half of the total patients, multivariate logistic regression analysis was used to develop a prediction score for estimating the risk of 90-day mortality by patient demographics, preoperative liver disease and comorbidities, indication for surgery, and procedure type. The score was validated with the remaining half of the patients.Overall 90-day mortality was 3.9%. Predictive characteristics included in the model were age, preexisting cirrhosis-related complications, ischemic heart disease, heart failure, cerebrovascular disease, renal disease, malignancy, and procedure type. Four risk groups were stratified by mortality scores of 1.1%, 2.2%, 7.7%, and 15%. Preexisting renal disease and cirrhosis-related complications were the strongest predictors. The score discriminated well in both the derivation and validation sets with c-statistics of 0.75 and 0.75, respectively.This population-based score could identify patients at risk of 90-day mortality before liver resection. Preexisting renal disease and cirrhosis-related complications had the strongest influence on mortality. This score enables preoperative risk stratification, decision-making, quality assessment, and counseling for individual patients.

  4. A 90-day subchronic toxicity study with sodium formononetin-3'-sulphonate (Sul-F) delivered to dogs via intravenous administration.

    PubMed

    Li, Chunmei; Li, Guisheng; Gao, Yonglin; Sun, Chengfeng; Wang, Xiaoyan

    2016-06-01

    Sodium formononetin-3'-sulphonate (Sul-F) is a water-soluble derivate of formononetin, and an increasing number of studies have shown that Sul-F not only possesses favorable water solubility but also exhibits good lipid-lowering and bioactivities. In the current study, the toxicity of Sul-F was evaluated in dogs after 90-day intravenous infusion. Dogs were treated with Sul-F at dose of 0, 33.3, 100, and 300 mg/kg, and observed for 90-day followed by 28-day recovery period. Weekly measurement of body weight, temperature and food consumption were conducted. Ophthalmoscopy, ECG examination, urinalysis, serum biochemistry and hematology examination were performed at pre-test, on days 45 and 90, and following by 28-day recovery period. Histological examination was performed on day 90 and 28-day recovery period. No mortality, ophthalmic abnormalities or treatment-related findings in body weight, clinical chemistry, hematology, and histopathological examination were detected. However, a white crystal (non-metabolic Sul-F), transient vomiting and recoverable vascular stimulation were observed in 300 mg/kg/day Sul-F treated dogs. Under the conditions, the no-observed-adverse-effect-level (NOAEL) for Sul-F was 100 mg/kg in dogs.

  5. A 90-day oral (dietary) toxicity and mass balance study of corn starch fiber in Sprague Dawley rats.

    PubMed

    Crincoli, Christine M; Nikiforov, Andrey I; Rihner, Marisa O; Lambert, Elizabeth A; Greeley, Melanie A; Godsey, Justin; Eapen, Alex K; van de Ligt, Jennifer L G

    2016-11-01

    The potential toxicity of corn starch fiber was assessed and compared to polydextrose, a commonly used bulking agent with a long history of safe use in the food supply. Groups of male and female Crl:CD(SD) rats were fed 0 (control), 1,000, 3,000, or 10,000 mg/kg-bw/day corn starch fiber in the diet for 90 days. The polydextrose reference article was offered on a comparable regimen at 10,000 mg/kg-bw/day. Following a single gavage dose of [(14)C]-corn starch fiber on study day 13 or 90, the mass balance of the test article was assessed by analysis of excreta samples collected from 0 to 168 h post-dose. There were no toxicologically or biologically relevant findings in any of the test article-treated groups. The few minor differences observed between the corn starch fiber and polydextrose exposed groups were considered to be due to normal biological variation. Following [(14)C]-corn starch fiber dosing, nearly complete excretion of the administered dose occurred over 168 h post-dosing, with the majority excreted in the feces. The dietary no-observed-adverse-effect level of corn starch fiber after 90 days was 10,000 mg/kg-bw/day. Similar toxicity profiles for corn starch fiber and polydextrose were observed due to the structural and compositional similarities of these materials.

  6. Multisite Study of an Implanted Continuous Glucose Sensor Over 90 Days in Patients With Diabetes Mellitus

    PubMed Central

    Dehennis, Andrew; Mortellaro, Mark A.; Ioacara, Sorin

    2015-01-01

    Background: Continuous glucose monitoring (CGM), which enables real-time glucose display and trend information as well as real-time alarms, can improve glycemic control and quality of life in patients with diabetes mellitus. Previous reports have described strategies to extend the useable lifetime of a single sensor from 1-2 weeks to 28 days. The present multisite study describes the characterization of a sensing platform achieving 90 days of continuous use for a single, fully implanted sensor. Method: The Senseonics CGM system is composed of a long-term implantable glucose sensor and a wearable smart transmitter. Study subjects underwent subcutaneous implantation of sensors in the upper arm. Eight-hour clinic sessions were performed every 14 days, during which sensor glucose values were compared against venous blood lab reference measurements collected every 15 minutes using mean absolute relative differences (MARDs). Results: All subjects (mean ± standard deviation age: 43.5 ± 11.0 years; with 10 sensors inserted in men and 14 in women) had type 1 diabetes mellitus. Most (22 of 24) sensors reported glucose values for the entire 90 days. The MARD value was 11.4 ± 2.7% (range, 8.1-19.5%) for reference glucose values between 40-400 mg/dl. There was no significant difference in MARD throughout the 90-day study (P = .31). No serious adverse events were noted. Conclusions: The Senseonics CGM, composed of an implantable sensor, external smart transmitter, and smartphone app, is the first system that uses a single sensor for continuous display of accurate glucose values for 3 months. PMID:26224762

  7. Human exploration of space: A review of NASA's 90-day study and alternatives

    NASA Technical Reports Server (NTRS)

    Stever, H. Guyford; Cannon, Robert H., Jr.; Gavin, Joseph G.; Kerrebrock, Jack L.; Lanzerotti, Louis J.; Levinthal, Elliott C.; Mar, James W.; Mcelroy, John H.; Mcruer, Duane T.; Merrell, William J., Jr.

    1990-01-01

    The National Research Council (NRC) examines the NASA Report of the 90-Day Study on Human Exploration of the Moon and Mars, and alternative concepts. Included in this paper, prepared for the National Space Council, are the answers to a challenging set of questions posed by the Vice President. Concerns addressed include: the appropriate pace, the scope of human exploration, the level of long-term support required, the technology development available and needed, the feasibility of long-duration human spaceflight in a low-gravity environment, scientific objectives, and other considerations such as costs and risks.

  8. A 90-day toxicity study of GmTMT transgenic maize in Sprague-Dawley rats.

    PubMed

    Fang, Jin; Feng, Yongquan; Zhi, Yuan; Zhang, Lan; Yu, Zhou; Jia, Xudong

    2017-04-01

    GmTMT transgenic maize is a genetically modified maize plant that overexpresses the γ-tocopherol methyltransferase (γ-TMT) from Glycine max (Gm). The γ-TMT gene was introduced into maize line Zhen58 to encode the GmTMT2a protein which can convert γ-tocopherol into α-tocopherol. Overexpression of GmTMT2a significantly increased the α-tocopherol content in transgenic maize. The present study was designed to investigate any potential effects of GmTMT maize grain in a 90-day subchronic rodent feeding study. Maize grains from GmTMT or Zhen58 were incorporated into rodent diets at low (12.5%), medium (25%) or high (50%) concentrations and administered to Sprague-Dawley rats (n = 10/sex/group) for 90 days. The negative control group of rats (n = 10/sex/group) were fed with common maize diets. Results from body weights, feed consumption, clinical chemistry, hematology, absolute and relative organ weights indicated no treatment-related side effects of GmTMT maize grain on rats in comparison with rats consuming diets containing Zhen58 maize grain. In addition, no treatment-related changes were found in necropsy and histopathology examinations. Altogether, our data indicates that GmTMT transgenic maize is as safe and nutritious as its conventional non-transgenic maize.

  9. A 90-day study of three bruchid-resistant mung bean cultivars in Sprague-Dawley rats.

    PubMed

    Yao, Yang; Cheng, Xuzhen; Ren, Guixing

    2015-02-01

    Mung bean has been traditionally and widely used as an edible and medicinal plant in the South and Southeast Asia. Bruchid resistance mung bean has more potential in commercial use, but scarcely been evaluated for safety through standard in vivo toxicological studies. In the present study, subchronic oral toxicity studies of bruchid-resistant mung bean were designed and conducted in Sprague-Dawley (SD) rats for 90 days. During the subchronic oral toxicity study, no mortality and toxicologically significant changes in clinical signs, food consumption, opthalmoscopic examination, hematology, clinical biochemistry, macroscopic findings, organ weights and histopathological examination were noted in animal administered diet containing bruchid-resistant mung bean. These results demonstrated that bruchid resistant mung bean is as safe as conventional mung bean.

  10. Pulmonary toxicity of simulated lunar and Martian dusts in mice: I. Histopathology 7 and 90 days after intratracheal instillation

    NASA Technical Reports Server (NTRS)

    Lam, Chiu-Wing; James, John T.; McCluskey, Richard; Cowper, Shawn; Balis, John; Muro-Cacho, Carlos

    2002-01-01

    NASA is contemplating sending humans to Mars and to the moon for further exploration. Volcanic ashes from Arizona and Hawaii with mineral properties similar to those of lunar and Martian soils, respectively, are used to simulate lunar and Martian environments for instrument testing. Martian soil is highly oxidative; this property is not found in Earth's volcanic ashes. NASA is concerned about the health risk from potential exposure of workers in the test facilities. Fine lunar soil simulant (LSS), Martian soil simulant (MSS), titanium dioxide, or quartz in saline was intratracheally instilled into groups of 4 mice (C57BL/6J) at 0.1 mg/mouse (low dose, LD) or 1 mg/mouse (high dose, HD). Separate groups of mice were exposed to ozone (0.5 ppm for 3 h) prior to MSS instillation. Lungs were harvested for histopathological examination 7 or 90 days after the single dust treatment. The lungs of the LSS-LD groups showed no evidence of inflammation, edema, or fibrosis; clumps of particles and an increased number of macrophages were visible after 7 days but not 90 days. In the LSS-HD-7d group, the lungs showed mild to moderate alveolitis, and perivascular and peribronchiolar inflammation. The LSS-HD-90d group showed signs of mild chronic pulmonary inflammation, septal thickening, and some fibrosis. Foci of particle-laden macrophages (PLMs) were still visible. Lung lesions in the MSS-LD-7d group were similar to those observed in the LSS-HD-7d group. The MSS-LD-90d group had PLMs and scattered foci of mild fibrosis in the lungs. The MSS-HD-7d group showed large foci of PLMs, intra-alveolar debris, mild-to-moderate focal alveolitis, and perivascular and peribronchiolar inflammation. The MSS-HD-90d group showed focal chronic mild-to-moderate alveolitis and fibrosis. The findings in the O(3)-MSS-HD-90d group included widespread intra-alveolar debris, focal moderate alveolitis, and fibrosis. Lung lesions in the MSS groups were more severe with the ozone pretreatment. The effects of

  11. Pulmonary toxicity of simulated lunar and Martian dusts in mice: I. Histopathology 7 and 90 days after intratracheal instillation.

    PubMed

    Lam, Chiu-Wing; James, John T; McCluskey, Richard; Cowper, Shawn; Balis, John; Muro-Cacho, Carlos

    2002-09-01

    NASA is contemplating sending humans to Mars and to the moon for further exploration. Volcanic ashes from Arizona and Hawaii with mineral properties similar to those of lunar and Martian soils, respectively, are used to simulate lunar and Martian environments for instrument testing. Martian soil is highly oxidative; this property is not found in Earth's volcanic ashes. NASA is concerned about the health risk from potential exposure of workers in the test facilities. Fine lunar soil simulant (LSS), Martian soil simulant (MSS), titanium dioxide, or quartz in saline was intratracheally instilled into groups of 4 mice (C57BL/6J) at 0.1 mg/mouse (low dose, LD) or 1 mg/mouse (high dose, HD). Separate groups of mice were exposed to ozone (0.5 ppm for 3 h) prior to MSS instillation. Lungs were harvested for histopathological examination 7 or 90 days after the single dust treatment. The lungs of the LSS-LD groups showed no evidence of inflammation, edema, or fibrosis; clumps of particles and an increased number of macrophages were visible after 7 days but not 90 days. In the LSS-HD-7d group, the lungs showed mild to moderate alveolitis, and perivascular and peribronchiolar inflammation. The LSS-HD-90d group showed signs of mild chronic pulmonary inflammation, septal thickening, and some fibrosis. Foci of particle-laden macrophages (PLMs) were still visible. Lung lesions in the MSS-LD-7d group were similar to those observed in the LSS-HD-7d group. The MSS-LD-90d group had PLMs and scattered foci of mild fibrosis in the lungs. The MSS-HD-7d group showed large foci of PLMs, intra-alveolar debris, mild-to-moderate focal alveolitis, and perivascular and peribronchiolar inflammation. The MSS-HD-90d group showed focal chronic mild-to-moderate alveolitis and fibrosis. The findings in the O(3)-MSS-HD-90d group included widespread intra-alveolar debris, focal moderate alveolitis, and fibrosis. Lung lesions in the MSS groups were more severe with the ozone pretreatment. The effects of

  12. A 90-day toxicology study of meat from genetically modified sheep overexpressing TLR4 in Sprague-Dawley rats.

    PubMed

    Bai, Hai; Wang, Zhixian; Hu, Rui; Kan, Tongtong; Li, Yan; Zhang, Xiaosheng; Zhang, Jinlong; Lian, Ling; Han, Hongbing; Lian, Zhengxing

    2015-01-01

    Genetic modification offers alternative strategies to traditional animal breeding. However, the food safety of genetically modified (GM) animals has attracted increasing levels of concern. In this study, we produced GM sheep overexpressing TLR4, and the transgene-positive offsprings (F1) were confirmed using the polymerase chain reaction (PCR) and Southern blot. The expression of TLR4 was 2.5-fold compared with that of the wild-type (WT) sheep samples. During the 90-day safety study, Sprague-Dawley rats were fed with three different dietary concentrations (3.75%, 7.5%, and 15% wt/wt) of GM sheep meat, WT sheep meat or a commercial diet (CD). Blood samples from the rats were collected and analyzed for hematological and biochemical parameters, and then compared with hematological and biochemical reference ranges. Despite a few significant differences among the three groups in some parameters, all other values remained within the normal reference intervals and thus were not considered to be affected by the treatment. No adverse diet-related differences in body weights or relative organ weights were observed. Furthermore, no differences were observed in the gross necropsy findings or microscopic pathology of the rats whose diets contained the GM sheep meat compared with rats whose diets contained the WT sheep meat. Therefore, the present 90-day rat feeding study suggested that the meat of GM sheep overexpressing TLR4 had no adverse effect on Sprague-Dawley rats in comparison with WT sheep meat. These results provide valuable information regarding the safety assessment of meat derived from GM animals.

  13. Distribution, elimination, and biopersistence to 90 days of a systemically introduced 30 nm ceria-engineered nanomaterial in rats.

    PubMed

    Yokel, Robert A; Au, Tu C; MacPhail, Robert; Hardas, Sarita S; Butterfield, D Allan; Sultana, Rukhsana; Goodman, Michael; Tseng, Michael T; Dan, Mo; Haghnazar, Hamed; Unrine, Jason M; Graham, Uschi M; Wu, Peng; Grulke, Eric A

    2012-05-01

    Nanoceria is used as a catalyst in diesel fuel, as an abrasive in printed circuit manufacture, and is being pursued as an antioxidant therapeutic. Our objective is to extend previous findings showing that there were no reductions of cerium in organs of the mononuclear phagocyte (reticuloendothelial) system up to 30 days after a single nanoscale ceria administration. An ~5% aqueous dispersion of citrate-stabilized 30 nm ceria, synthesized and characterized in-house, or vehicle, was iv infused into rats terminated 1, 7, 30, or 90 days later. Cageside observations were obtained daily, body weight weekly. Daily urinary and fecal cerium outputs were quantified for 2 weeks. Nine organs were weighed and samples collected from 14 tissues/organs/systems, blood and cerebrospinal fluid for cerium determination. Histology and oxidative stress were assessed. Less than 1% of the nanoceria was excreted in the first 2 weeks, 98% in feces. Body weight gain was initially impaired. Spleen weight was significantly increased in some ceria-treated groups, associated with abnormalities. Ceria was primarily retained in the spleen, liver, and bone marrow. There was little decrease of ceria in any tissue over the 90 days. Granulomas were observed in the liver. Time-dependent oxidative stress changes were seen in the liver and spleen. Nanoscale ceria was persistently retained by organs of the mononuclear phagocyte system, associated with adverse changes. The results support concern about the long-term fate and adverse effects of inert nanoscale metal oxides that distribute throughout the body, are persistently retained, and produce adverse changes.

  14. Ultrastructural response of rat lung to 90 days' exposure to oxygen at 450 mm Hg

    NASA Technical Reports Server (NTRS)

    Harrison, G. A.

    1974-01-01

    Young Sprague-Dawley rats were exposed to 100% oxygen at 450 mm Hg in constant environment capsules for 90 days. Lung tissue examined by electron microscopy revealed a number of changes, many similar to those observed after exposure to oxygen at 760 mm Hg for shorter periods of time. Alterations in vesicle size and number and in mitochondrial matrix and cristae appear in both the endothelial and epithelial cells. Blebbing and rarefication of cytoplasm occur in both cell layers of the alveolo-capillary wall. Also seen are fluid in the basement membrane, platelets in the capillaries, and alveolar fluid and debris. All of these alterations occur at 1 atm exposure. However, after exposure to 450 mm Hg the changes are not as widespread nor as destructive as they are at the higher pressure.

  15. Program operational summary: Operational 90 day manned test of a regenerative life support system

    NASA Technical Reports Server (NTRS)

    Jackson, J. K.; Wamsley, J. R.; Bonura, M. S.; Seeman, J. S.

    1972-01-01

    An operational 90-day manned test of a regenerative life support system was successfully completed. This test was performed with a crew of four carefully selected and trained men in a space station simulator (SSS) which had a two gas atmosphere maintained at a total pressure of 68.9, 10 psia, and composed of oxygen at a partial pressure of 3.05 psia with nitrogen as the diluent. The test was planned to provide data on regenerative life support subsystems and on integrated system operations in a closed ecology, similar to that of a space station. All crew equipment and expendables were stored onboard at the start of the mission to eliminate the need for pass-in operations. The significant accomplishments of the test, some of the pertinent test results, some of the problem areas, and conclusions are presented.

  16. Bioregenerative Life Support Experiment for 90-days in a Closed Integrative Experimental Facility LUNAR PALACE 1

    NASA Astrophysics Data System (ADS)

    Liu, Hong

    A 90-day bioregenerative life support experiment with three-member crew was carried out in the closed integrative experimental facility, LUNAR PALACE 1 regenerating basic living necessities and disposing wastes to provide life support for crew. It was composed of higher plant module, animal module, and waste treatment module. The higher plant module included wheat, chufa, pea, carrot and green leafy vegetables, with aim to satisfy requirement of 60% plant food and 100% O2 and water for crew. The yellow mealworm was selected as animal module to provide partial animal protein for crew, and reared on plant inedible biomass. The higher plant and yellow mealworm were both cultivated and harvested in the conveyor-type manner. The partial plant inedible biomass and human feces were mixed and co- fermented in the waste treatment module for preparation of soil-like substrate by bioconversion, maintaining gas balance and increasing closure degree. Meanwhile, in the waste treatment module, the water and partial nitrogen from human urine were recovered by physical-chemical means. Circulation of O2 and water as well as food supply from crops cultivated in the LUNAR PALACE 1 were investigated and calculated, and simultaneously gas exchange, mass flow among different components and system closure degree were also analyzed, respectively. Furthermore, the system robustness with respect to internal variation was tested and evaluated by sensitivity analysis of the aggregative index consisting of key performance indicators like crop yield, gaseous equilibrium concentration, microbial community composition, biogenic elements dynamics, etc., and comprehensively evaluating the operating state, to number change of crew from 2 to 4 during the 90-day closed experiment period.

  17. A 90-Day Feeding Study in Rats to Assess the Safety of Genetically Engineered Pork.

    PubMed

    Xiao, Gao-Jun; Jiang, Sheng-Wang; Qian, Li-Li; Cai, Chun-Bo; Wang, Qing-Qing; Ma, De-Zun; Li, Biao; Xie, Shan-Shan; Cui, Wen-Tao; Li, Kui

    2016-01-01

    Our laboratory recently produced genetically engineered (GE) Meishan pigs containing a ZFN-edited myostatin loss-of-function mutant. These GE pigs develop and grow as normal as wild type pigs but produce pork with greater lean yield and lower fat mass. To assess any potential subchronic toxicity risks of this GE pork, a 90-day feeding study was conducted in Sprague-Dawley rats. Rats were randomly divided into five groups, and fed for 90 days with basic diet and basic diets formulated with low dose and high dose pork prepared from wild type pigs and GE pigs, respectively. Animal behaviors and clinical signs were monitored twice daily, and body weight and food consumption were measured and recorded weekly. At days 45 and 90, blood tests (lipid panel, electrolytes, parameters related to liver and kidney functions, and complete blood counts) were performed. Additionally, gross pathology and histopathological analyses were performed for major organs in each group. Data analysis shows that there were no significant differences in growth rate, food consumption, and blood test parameters between rat groups fed with GE pork and wild type pork. Although differences in some liver function parameters (such as aspartate aminotransferase, total proteins, albumin, and alkaline phosphatase) and white blood cell counts (such as lymphocyte percentage and monocyte percentage) were observed between rats fed with high dose GE pork and basic diet, all test results in rats fed with GE pork are in the normal range. Additionally, there are no apparent lesions noted in all organs isolated from rats in all five feeding groups on days 45 and 90. Overall, our results clearly indicate that food consumption of GE pork produced by ZFN-edited myostatin loss-of-function mutant pigs did not have any long-term adverse effects on the health status in rats.

  18. A 90-Day Feeding Study in Rats to Assess the Safety of Genetically Engineered Pork

    PubMed Central

    Xiao, Gao-jun; Jiang, Sheng-Wang; Qian, Li-Li; Cai, Chun-Bo; Wang, Qing-qing; Ma, De-Zun; Li, Biao; Xie, Shan-shan; Cui, Wen-Tao; Li, Kui

    2016-01-01

    Our laboratory recently produced genetically engineered (GE) Meishan pigs containing a ZFN-edited myostatin loss-of-function mutant. These GE pigs develop and grow as normal as wild type pigs but produce pork with greater lean yield and lower fat mass. To assess any potential subchronic toxicity risks of this GE pork, a 90-day feeding study was conducted in Sprague-Dawley rats. Rats were randomly divided into five groups, and fed for 90 days with basic diet and basic diets formulated with low dose and high dose pork prepared from wild type pigs and GE pigs, respectively. Animal behaviors and clinical signs were monitored twice daily, and body weight and food consumption were measured and recorded weekly. At days 45 and 90, blood tests (lipid panel, electrolytes, parameters related to liver and kidney functions, and complete blood counts) were performed. Additionally, gross pathology and histopathological analyses were performed for major organs in each group. Data analysis shows that there were no significant differences in growth rate, food consumption, and blood test parameters between rat groups fed with GE pork and wild type pork. Although differences in some liver function parameters (such as aspartate aminotransferase, total proteins, albumin, and alkaline phosphatase) and white blood cell counts (such as lymphocyte percentage and monocyte percentage) were observed between rats fed with high dose GE pork and basic diet, all test results in rats fed with GE pork are in the normal range. Additionally, there are no apparent lesions noted in all organs isolated from rats in all five feeding groups on days 45 and 90. Overall, our results clearly indicate that food consumption of GE pork produced by ZFN-edited myostatin loss-of-function mutant pigs did not have any long-term adverse effects on the health status in rats. PMID:27812153

  19. 76 FR 63443 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List Northern...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-12

    ... On July 30, 2007, we received a petition dated July 24, 2007, from Forest Guardians (now WildEarth... for any of the species covered by the petition. On March 19, 2008, WildEarth Guardians filed a... species for listing; therefore, 38 species remained. On March 13, 2009, the Service and...

  20. 90-day dietary toxicity study with esterified propoxylated glycerol (EPG) in micropigs.

    PubMed

    Wedig, John; Bechtel, David H

    2014-12-01

    The subchronic (90-day) toxicity of esterified propoxylated glycerol (EPG) was assessed in micropigs. Animals (5/sex/group) received feed containing 5%, 10%, and 17% EPG, mixed accordingly throughout the study to deliver 1.5, 3, and 5 g/kg bw/day of EPG, respectively. Corn oil served as the vehicle control (0 g/kg bw/day). Subsets of animals were evaluated at Week 6; the remainder between Weeks 12 and 14. With the exception of liver and serum vitamin levels, statistically significant difference between control and EPG groups were seen sporadically, and with no apparent connection to treatment and/or no consistency across time intervals. EPG intakes of 3 and 5 g/kg bw/day, but not at 1.5 g/kg bw/day were associated with significantly lower serum 25-OH vitamin D levels. Serum total vitamin D levels were significantly lower across all EPG groups. There were also trends toward lower levels of liver vitamins A and E among EPG-treated animals, but the effects were less consistent. The effects on vitamin levels observed in EPG-treated animals were not accompanied by any signs of vitamin deficiency (e.g., effects on growth, clinical signs, or clinical pathology), and might have been related to the larger mass of EPG acting as a lipid "sink" during transit in the gastrointestinal tract.

  1. Safety assessment of dietary bamboo charcoal powder: a 90-day subchronic oral toxicity and mutagenicity studies.

    PubMed

    Zhenchao, Jia; Yuting, Zhong; Jiuming, Yan; Yedan, Lu; Yang, Song; Jinyao, Chen; Lishi, Zhang

    2015-01-01

    Vegetable carbon has been used as food additive in EU (E153) and China for many years; however, no experimental data have been available on its dietary safety. This study was designed to evaluate the subchronic toxicity and genotoxicity of bamboo charcoal powder (BCP). In the study of subchronic oral toxicity, BCP was administered orally at doses of 2.81, 5.62, and 11.24 g/kg BW for 90 days to SD rats. Additional satellite groups from the control group and high dose group were observed for a 28-day recovery period. At the end of the treatment and recovery periods, animals were sacrificed, and their organs were weighed and blood samples were collected. The toxicological endpoints observed included clinical signs, food consumption, body and organ weights, hematological and biochemical parameters, macroscopic and microscopic examinations. The results showed no significant differences between the BCP treated groups and control group. The genotoxicity of BCP was assessed with the Salmonella typhimurium mutagenicity assay (Ames test) and a combination of comet assay and mammalian erythrocyte micronucleus protocol. The results did not reveal any genotoxicity of BCP. Based on our study, the no-observed-adverse-effect level (NOAEL) for BCP is 11.24 g/kg BW/day.

  2. A 90-day subchronic toxicity study of neem oil, a Azadirachta indica oil, in mice.

    PubMed

    Wang, C; Cao, M; Shi, D-X; Yin, Z-Q; Jia, R-Y; Wang, K-Y; Geng, Y; Wang, Y; Yao, X-P; Yang, Z-R; Zhao, J

    2013-09-01

    To determine the no-observed-adverse-effect level (NOAEL) of exposure and target organs of neem oil for establishing safety criteria for human exposure, the subchronic toxicity study with neem oil in mice was evaluated. The mice (10 per sex for each dose) was orally administered with neem oil with the doses of 0 (to serve as a control), 177, 533 and 1600 mg/kg/day for 90 days. After the treatment period, observation of reversibility or persistence of any toxic effects, mice were continuously fed without treatment for the following 30 days. During the two test periods, the serum biochemistry, organ weight and histopathology were examined. The results showed that the serum biochemistry and organ coefficient in experimental groups had no statistical difference compared with those of the control group. At the 90th day, the histopathological examinations showed that the 1600 mg/kg/day dose of neem oil had varying degrees of damage on each organ except heart, uterus and ovarian. After 30-day recovery, the degree of lesions to the tissues was lessened or even restored. The NOAEL of neem oil was 177 mg/kg/day for mice and the target organs of neem oil were determined to be testicle, liver and kidneys.

  3. Evaluation of silica nanoparticle toxicity after topical exposure for 90 days

    PubMed Central

    Ryu, Hwa Jung; Seong, Nak-won; So, Byoung Joon; Seo, Heung-sik; Kim, Jun-ho; Hong, Jeong-Sup; Park, Myeong-kyu; Kim, Min-Seok; Kim, Yu-Ri; Cho, Kyu-Bong; Seo, Mu Yeb; Kim, Meyoung-Kon; Maeng, Eun Ho; Son, Sang Wook

    2014-01-01

    Silica is a very common material that can be found in both crystalline and amorphous forms. Well-known toxicities of the lung can occur after exposure to the crystalline form of silica. However, the toxicities of the amorphous form of silica have not been thoroughly studied. The majority of in vivo studies of amorphous silica nanoparticles (NPs) were performed using an inhalation exposure method. Since silica NPs can be commonly administered through the skin, a study of dermal silica toxicity was necessary to determine any harmful effects from dermal exposures. The present study focused on the results of systemic toxicity after applying 20 nm colloidal silica NPs on rat skin for 90 days, in accordance with the Organization for Economic Cooperation and Development test guideline 411 with a good laboratory practice system. Unlike the inhalation route or gastrointestinal route, the contact of silica NPs through skin did not result in any toxicity or any change in internal organs up to a dose of 2,000 mg/kg in rats. PMID:25565831

  4. [Kooroo color: 90-day dietary toxicity study in F344 rats].

    PubMed

    Sekita, Kiyoshi; Umemura, Takashi; Saito, Minoru; Ogawa, Yukio; Ueno, Katsunori; Kaneko, Toyozo; Uchida, Osayuki; Matsushima, Yuko; Kawasaki, Yasushi; Inoue, Tohru

    2002-06-01

    A subchronic toxicity study on kooroo color was conducted using F344 rats of both genders. Kooroo color is an extract of yam root, Dioscorea matudai Hayata, of which the major components are known to be flavonoid pigments. Use of kooroo as a food color is permitted by the Food Sanitation Law in Japan, but the chronic toxicity has not been evaluated in the literature. Rats were fed the product of kooroo color (PKC) at doses of 0.5%, 1.50%, and 5.0% in basal powder diet, while control groups received PKC-free basal diet, for ninety days. A vehicle control given propylene glycol (PG) alone, at the same dosage that the 5.0% group received, was included, because PKC used in this study contained ca. 80 percent PG, used as an extractant during the manufacturing processes. Daily observation of general behavior, and weekly measurement of body weight as well as food consumption were performed. Hematological, serum biochemical and anatomopathological examinations were conducted at the end of administration. No abnormalities ascribable to the treatment with PKC or PG were noted in any examination in this study. Hence, dietary intake of 5.0% of PKC, i.e., 2,993 mg/kg/day for males, and 3,376 mg/kg/day for females, as a mean daily intake for 90 days, had no observable adverse effect in F344 rats. Therefore, kooroo color has no significant general toxicity, and its toxicity, if any, is of a very low order.

  5. A repeated dose 90-day oral toxicity study of cyflumetofen,a novel acaricide, in rats.

    PubMed

    Yoshida, Toshinori; Ikemi, Naoki; Takeuchi, Yukiko; Ebino, Koichi; Kojima, Sayuri; Chiba, Yuko; Nakashima, Nobuaki; Kawakatsu, Hisao; Saka, Machiko; Harada, Takanori

    2012-02-01

    Cyflumetofen is a novel acaricide which is highly active against phytophagous mites. As a part of safety assessment, a repeated dose 90-day oral toxicity study of cyflumetofen was conducted in Fischer (F344/DuCrj) rats of both sexes. Technical grade cyflumetofen was administered in feed to groups of 10 males and 10 females at dose levels of 0, 100, 300, 1,000, and 3,000 ppm. Prothrombin time was prolonged in males at 3,000 ppm and plasma globulin levels were decreased in females at 1,000 and 3,000 ppm. At necropsy, enlarged and whitish adrenals were observed in females at 3,000 ppm. There were statistically significant increases in relative liver weight (ratio to body weight) in males and relative adrenal weight in females in the 1,000 ppm group; increased relative liver and kidney weights in both sexes at 3,000 ppm, and increased absolute and relative weights of adrenals in females at 3,000 ppm. Increased absolute liver weight was also noted in males at 3,000 ppm. Histopathologically, at 1,000 and 3,000 ppm males had diffuse vacuolation and females had diffuse hypertrophy of adrenal cortical cells. In addition, vacuolation of ovarian interstitial gland cells was noted in females at 1,000 and 3,000 ppm. There were no treatment-related changes in any parameters for either sex in other dose groups. Based on these results, the no-observed-adverse-effect level (NOAEL) of cyflumetofen was judged to be 300 ppm for both sexes (16.5 mg/kg/day for males and 19.0 mg/kg/day for females).

  6. 78 FR 20855 - State Implementation Plans: Response to Petition for Rulemaking; Findings of Substantial...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-08

    ...; Findings of Substantial Inadequacy; and SIP Calls To Amend Provisions Applying to Excess Emissions During...; Findings of Substantial Inadequacy; and SIP Calls to Amend Provisions Applying to Excess Emissions During... signature, a copy of this notice will be posted on the EPA's Web site, under SSM SIP Call 2013, at...

  7. Effects of 30-, 60-, and 90-Day Bed Rest on Postural Control in Men and Women

    NASA Technical Reports Server (NTRS)

    Esteves, Julie; Taylor, Laura C.; Vanya, Robert D.; Dean, S. Lance; Wood, Scott J.

    2011-01-01

    INTRODUCTION Head-down-tilt bed rest (HDT) has been used as a safe gr ound-based analog to mimic and develop countermeasures for the physiological effects of spaceflight, including decrements in postural stability. The purpose of this investigation was to characterize the effects of 30-, 60-, and 90-day bed rest on postural control in men and women. METHODS Twenty-nine subjects (18M,11F) underwent 13 days of ambula tory acclimatization and were placed in 6? HDT for 30 (n=12), 60 (n=8), or 90 (n=9) days, followed by 14 days of ambulatory recovery. Computerized dynamic posturography (CDP) was used to assess changes in sensory and motor components of postural control, and recovery after HDT. Sensory Organization Tests (SOTs) objectively evaluate one?s ability to effectively use or suppress visual, vestibular, and proprioceptive information for postural control. Stability during the SOTs was assessed using peak-to-peak sway and convergence toward stability limits to derive an equilibrium score. Motor Control Tests (MCTs) evaluate one?s ability to recover from unexpected support surface perturbations, with performance determined by center-of-pressure path length. Whole-body kinematic data were collected to determine body-sway strategy used to maintain stability during each condition. Baselines were determined pre-HDT. Recovery was tracked post-HDT on days 0, 1, 2, and 4. RESULTS Immediately after HDT, subjects showed decreased performance on most SOTs, primarily on sway-referenced support conditions, typically returning to baseline levels within 4 days. MCT performance was not significantly affected. There were no significant gender or duration differences in performance. Kinematic data revealed a tendency to use ankle strategy to maintain an upright stance during most SOT conditions. Interestingly, six subjects (2M,4F) experienced orthostatic intolerance and were unable to complete day 0 testing. CONCLUSION HDT mimics some un loading mechanisms of spaceflight and

  8. 76 FR 47133 - Endangered and Threatened Wildlife and Plants; 90-Day Finding and 12-Month Determination on a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-04

    ... population growth, and normal behavior; (2) Food, water, air, light, minerals, or other nutritional or... coastal waters, is ``a centrally important space for `individual and population growth,' because it is.... An analysis of the INBS data has shown an exponential increase in leatherback sea turtle nesting...

  9. 78 FR 41716 - Hours of Service; Limited 90-Day Waiver From the 30-Minute Rest Break Requirement for the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-11

    ... beginning of this notice. Long-Range Weather Forecasts The FMCSA reviewed information from the National Oceanic and Atmospheric Administration's National Weather Service (NOAA). The NOAA posts long-range... Federal Motor Carrier Safety Administration 49 CFR Part 395 Hours of Service; Limited 90-Day Waiver...

  10. Learning Teaching (LT) Program: Developing an Effective Teacher Feedback System. 90-Day Cycle Report

    ERIC Educational Resources Information Center

    Park,Sandra; Takahashi, Sola; White, Taylor

    2014-01-01

    Early career teachers make up an increasingly large proportion of the public school teaching force. Often less effective and facing greater challenges than their more experienced counterparts, new teachers tend to leave the profession at high rates and, given that the modal length of teaching experience has now dropped to one year, finding ways to…

  11. Visual-motor response of crewmen during a simulated 90-day space mission as measured by the critical task battery

    NASA Technical Reports Server (NTRS)

    Allen, R. W.; Jex, H. R.

    1973-01-01

    In order to test various components of a regenerative life support system and to obtain data on the physiological and psychological effects of long duration exposure to confinement in a space station atmosphere, four carefully screened young men were sealed in a space station simulator for 90 days and administered a tracking test battery. The battery included a clinical test (Critical Instability Task) designed to measure a subject's dynamic time delay, and a more conventional steady tracking task, during which dynamic response (describing functions) and performance measures were obtained. Good correlation was noted between the clinical critical instability scores and more detailed tracking parameters such as dynamic time delay and gain-crossover frequency. The levels of each parameter span the range observed with professional pilots and astronaut candidates tested previously. The chamber environment caused no significant decrement on the average crewman's dynamic response behavior, and the subjects continued to improve slightly in their tracking skills during the 90-day confinement period.

  12. Prognostic Abilities and Quality Assessment of Models for the Prediction of 90-Day Mortality in Liver Transplant Waiting List Patients

    PubMed Central

    Barthold, Marc; Kaltenborn, Alexander

    2017-01-01

    Background Model of end-stage liver disease (MELD)-score and diverse variants are widely used for prognosis on liver transplant waiting-lists. Methods 818 consecutive patients on the liver transplant waiting-list included to calculate the MELD, MESO Index, MELD-Na, UKELD, iMELD, refitMELD, refitMELD-Na, upMELD and PELD-scores. Prognostic abilities for 90-day mortality were investigated applying Receiver-operating-characteristic-curve analysis. Independent risk factors for 90-day mortality were identified with multivariable binary logistic regression modelling. Methodological quality of the underlying development studies was assessed with a systematic assessment tool. Results 74 patients (9%) died on the liver transplant waiting list within 90 days after listing. All but one scores, refitMELD-Na, had acceptable prognostic performance with areas under the ROC-curves (AUROCs)>0.700. The iMELD performed best (AUROC = 0.798). In pediatric cases, the PELD-score just failed to reach the acceptable threshold with an AUROC = 0.699. All scores reached a mean quality score of 72.3%. Highest quality scores could be achieved by the UKELD and PELD-scores. Studies specifically lack statistical validity and model evaluation. Conclusions Inferior quality assessment of prognostic models does not necessarily imply inferior prognostic abilities. The iMELD might be a more reliable tool representing urgency of transplantation than the MELD-score. PELD-score is assumedly not accurate enough to allow graft allocation decision in pediatric liver transplantation. PMID:28129338

  13. First Report of 90-Day Support of Two Calves with a Continuous-Flow Total Artificial Heart

    PubMed Central

    Karimov, Jamshid H.; Moazami, Nader; Kobayashi, Mariko; Sale, Shiva; Such, Kimberly; Byram, Nicole; Sunagawa, Gengo; Horvath, David; Gao, Shengqiang; Kuban, Barry; Golding, Leonard A.; Fukamachi, Kiyotaka

    2015-01-01

    Objective The Cleveland Clinic continuous-flow total artificial heart (CFTAH) is a compact, single-piece, valveless, pulsatile pump providing self-regulated hemodynamic output to left/right circulation. We evaluated chronic in vivo pump performance, physiologic and hemodynamic parameters, and biocompatibility of the CFTAH in a well-established calf model. Methods CFTAH pumps have been implanted in 17 calves total. Hemodynamics, pump performance, and device-related adverse events were evaluated during studies and at necropsy. Results In vivo experiments demonstrated good hemodynamic performance (pump flow, 7.3 ± 0.7 L/min; left atrial pressure [LAP], 16 ± 3 mm Hg; right atrial pressure [RAP], 17 ± 3 mm Hg; RAP-LAP difference, 1 ± 2 mm Hg; mean arterial pressure, 103 ± 7 mm Hg; arterial pulse pressure, 30 ± 11 mm Hg; pulmonary arterial pressure, 34 ± 5 mm Hg). The CFTAH has operated within design specifications and never failed. With ever-improving pump design, the implants have shown no chronic hemolysis. Three recent animals with the CFTAH recovered well, with no postoperative anticoagulation, during planned in vivo durations of 30, 90, and 90 days (last two were intended to be 90-day studies). All these longest-surviving cases showed good biocompatibility, with no thromboembolism in organs. Conclusions The current CFTAH has demonstrated reliable self-regulation of hemodynamic output and acceptable biocompatibility without anticoagulation throughout 90 days of chronic implantation in calves. Meeting these milestones is in accord with our strategy to achieve transfer of this unique technology to surgical practice, thus filling the urgent need for cardiac replacement devices as destination therapy. PMID:26173607

  14. Toxicological assessment of a prototype e-cigaret device and three flavor formulations: a 90-day inhalation study in rats

    PubMed Central

    Werley, Michael S.; Kirkpatrick, Dan J.; Oldham, Michael J.; Jerome, Ann M.; Langston, Timothy B.; Lilly, Patrick D.; Smith, Donna C.; Mckinney, Willie J.

    2016-01-01

    Abstract A prototype electronic cigaret device and three formulations were evaluated in a 90-day rat inhalation study followed by a 42-day recovery period. Animals were randomly assigned to groups for exposure to low-, mid- and high-dose levels of aerosols composed of vehicle (glycerin and propylene glycol mixture); vehicle and 2.0% nicotine; or vehicle, 2.0% nicotine and flavor mixture. Daily targeted aerosol total particulate matter (TPM) doses of 3.2, 9.6 and 32.0 mg/kg/day were achieved by exposure to 1 mg/L aerosol for 16, 48 and 160 min, respectively. Pre-study evaluations included indirect ophthalmoscopy, virology and bacteriological screening. Body weights, clinical observations and food consumption were monitored weekly. Plasma nicotine and cotinine and carboxyhemoglobin levels were measured at days 28 and 90. After days 28, 56 and 90, lung function measurements were obtained. Biological endpoints after 90-day exposure and 42-day recovery period included clinical pathology, urinalysis, bronchoalveolar fluid (BALF) analysis, necropsy and histopathology. Treatment-related effects following 90 days of exposure included changes in body weight, food consumption and respiratory rate. Dose-related decreases in thymus and spleen weights, and increased BALF lactate dehydrogenase, total protein, alveolar macrophages, neutrophils and lung weights were observed. Histopathology evaluations revealed sporadic increases in nasal section 1–4 epithelial hyperplasia and vacuolization. Following the recovery period, effects in the nose and BALF were persistent while other effects were resolved. The no observed effect level based upon body weight decreases is considered to be the mid-dose level for each formulation, equivalent to a daily TPM exposure dose of approximately 9.6 mg/kg/day. PMID:26787428

  15. Readmission Rate and Causes at 90-Day after Radical Cystectomy in Patients on Early Recovery after Surgery Protocol

    PubMed Central

    Altobelli, Emanuela; Buscarini, Maurizio; Gill, Harcharan S.; Skinner, Eila C.

    2017-01-01

    Background: Radical cystectomy (RC) is associated with high risk of early and late perioperative complications, and readmissions. The Enhanced Recovery After Surgery (ERAS) protocol has been applied to RC showing decreased hospital stay without increased morbidity. Objective: To evaluate the specific causes of hospital readmissions in RC patients treated before and after adoption of an ERAS protocol at our institution. Methods: We retrospectively evaluated the outcome of 207 RC patients on ERAS protocol at the Stanford University Hospital from January 2012 to December 2014. We focused on early (30-day) and late (90-day) postoperative readmission rate and causes. Results were compared with a pre-ERAS consecutive series of 177 RC patients from January 2009 to December 2011. Results: In the post-ERAS time period a total of 56 patients were readmitted, 41 within the first 30 days after surgery (20%) and 15 within the following 60 days (7%). Fever, often associated with dehydration, was the most common reason for presentation to the hospital, accounting for 57% of all readmissions. At 90 days infection accounted for 53% of readmissions. Of all the patients readmitted during the first 90 days after surgery, 32 had positive urine cultures, mostly caused by Enterococcus faecalis isolated in 18 (56%). Readmission rates did not increase since the introduction of the ERAS protocol, with an incidence of 27% in the post-ERAS group versus 30% in the pre-ERAS group. Conclusions: Despite accurate adherence to most recent perioperative antibiotic guidelines, the incidence of readmissions after RC due to infection still remains significant. PMID:28149935

  16. Readmission Rate and Causes at 90-Day after Radical Cystectomy in Patients on Early Recovery after Surgery Protocol.

    PubMed

    Altobelli, Emanuela; Buscarini, Maurizio; Gill, Harcharan S; Skinner, Eila C

    2017-01-27

    Background: Radical cystectomy (RC) is associated with high risk of early and late perioperative complications, and readmissions. The Enhanced Recovery After Surgery (ERAS) protocol has been applied to RC showing decreased hospital stay without increased morbidity. Objective: To evaluate the specific causes of hospital readmissions in RC patients treated before and after adoption of an ERAS protocol at our institution. Methods: We retrospectively evaluated the outcome of 207 RC patients on ERAS protocol at the Stanford University Hospital from January 2012 to December 2014. We focused on early (30-day) and late (90-day) postoperative readmission rate and causes. Results were compared with a pre-ERAS consecutive series of 177 RC patients from January 2009 to December 2011. Results: In the post-ERAS time period a total of 56 patients were readmitted, 41 within the first 30 days after surgery (20%) and 15 within the following 60 days (7%). Fever, often associated with dehydration, was the most common reason for presentation to the hospital, accounting for 57% of all readmissions. At 90 days infection accounted for 53% of readmissions. Of all the patients readmitted during the first 90 days after surgery, 32 had positive urine cultures, mostly caused by Enterococcus faecalis isolated in 18 (56%). Readmission rates did not increase since the introduction of the ERAS protocol, with an incidence of 27% in the post-ERAS group versus 30% in the pre-ERAS group. Conclusions: Despite accurate adherence to most recent perioperative antibiotic guidelines, the incidence of readmissions after RC due to infection still remains significant.

  17. A 90-Day Oral Toxicity Study and a 5-Day Metabolism Study of Diisopropyl Methylphosphonate (DIMP) in Mink.

    DTIC Science & Technology

    1992-06-01

    Eighty 12-13 month-old brown "Ranch Wild " mink of each sex were randomized by body weight into eight dose groups of ten animals per sex. The animals...Laboratory Practice Standard (Toxic Substances Control Act) was followed. 90-DAY STUDY One hundred sixty 12-13 month-old brown "Ranch Wild " mink (80...3.2 x 10ŚM sec-’ * Hydrolysis Half- life : 687 years * Decomposition Products: (in microwave plasma discharge): methylphosphonic acid, isopropyl

  18. Evolution of a 90-day model of care for bundled episodic payments for congestive heart failure in home care.

    PubMed

    Feld, April; Madden-Baer, Rose; McCorkle, Ruth

    2016-01-01

    The Centers for Medicare and Medicaid Services Innovation Center's Episode-Based Payment initiatives propose a large opportunity to reduce cost from waste and variation and stand to align hospitals, physicians, and postacute providers in the redesign of care that achieves savings and improve quality. Community-based organizations are at the forefront of this care redesign through innovative models of care aimed at bridging gaps in care coordination and reducing hospital readmissions. This article describes a community-based provider's approach to participation under the Bundled Payments for Care Improvement initiative and a 90-day model of care for congestive heart failure in home care.

  19. The development and succession of microbial communities in 90-day Bioregenerative Life Support Experiment in the Lunar Palace 1

    NASA Astrophysics Data System (ADS)

    Sun, Yi; Liu, Hong; Fu, Yuming; Liu, Bojie; Su, Qiang; Xie, Beizhen; Qin, Youcai; Dong, Chen; Liu, Guanghui

    Lunar Palace 1, as an integrative experiment facility for permanent astrobase life-support artificial closed ecosystem, is an artificial ecosystem which consists of plant cultivation, animal breeding and waste treatment units. It has been used to carry out a 90-day bioregenerative life support experiment with three crew members. Apparently, it’s hard to prevent the growth of microorganisms in such closed ecosystem for their strong adaptive capacity. Original microorganisms in the cabin, microbes in the course of loads delivery and the autologous microorganism by crew members and animals themselves are all the main source of the interior microorganisms, which may grow and regenerate in air, water and plants. Therefore, if these microorganisms could not be effectively monitored and controlled, it may cause microbial contamination and even lead to the unsteadiness of the whole closed ecosystem. In this study, the development and succession of the microbial communities of air, water system, plant system, and key facilities surfaces in Lunar Palace 1 were continuously monitored and analyzed by using plate counting method and molecular biological method during the 90-day experiment. The results were quite useful for the controlling of internal microorganisms and the safe operation of the whole system, and could also reveal the succession rules of microorganisms in an artificial closed ecosystem.

  20. Effects of 90-day feeding of transgenic Bt rice TT51 on the reproductive system in male rats.

    PubMed

    Wang, Er Hui; Yu, Zhou; Hu, Jing; Xu, Hai Bin

    2013-12-01

    Rice is a staple food crop; however, the threat of pests leads to a serious decline in its output and quality. The CryAb/CryAc gene, encodes a synthetic fusion Bacillus thuringiensis (Bt) crystal protein, was introduced into rice MingHui63 to produce insect-resistant rice TT51. This study was undertaken to investigate potential unintended effects of TT51 on the reproductive system in male rats. Male rats were treated with diets containing 60% of either TT51 or MingHui63 by weight, nutritionally balanced to an AIN93G diet, for 90days. An additional negative control group of rats were fed with a rice-based AIN93G diet. Body weights, food intake, hematology, serum chemistry, serum hormone levels, sperm parameters and relative organ/body weights were measured, and gross as well as microscopic pathology were examined. No diet-related significant differences in the values of response variables were observed between rats that were fed with diet containing transgenic TT51, MingHui63 and the control in this 90-day feeding study. In addition, necropsy and histopathology examination indicated no treatment-related changes. The results from the present study indicated that TT51 does not appear to exert any effect on the reproductive system in male rats compared with MingHui63 or the control.

  1. Safety assessment of essential oil from Minthostachys verticillata (Griseb.) Epling (peperina): 90-days oral subchronic toxicity study in rats.

    PubMed

    Escobar, Franco Matías; Sabini, María Carola; Cariddi, Laura Noelia; Sabini, Liliana Inés; Mañas, Fernando; Cristofolini, Andrea; Bagnis, Guillermo; Gallucci, Mauro Nicolas; Cavaglieri, Lilia Renée

    2015-02-01

    Minthostachys verticillata (Lamiaceae), popularly known as peperina is largely used in popular medicine for its digestive, carminative, antispasmodic and antirheumatic properties. There are no reports of repeated exposure toxicity to guarantee their safety. The present study investigated the chemical composition, analyzed by GC-FID, and the 90-day toxicity and genotoxicity effect of M. verticillata essential oil (Mv-EO), using Wistar rats as test animals. The rats were divided into four groups (5 rats/sex/group) and Mv-EO was administered on diet at doses of 0, 1, 4 and 7 g/kg feed. The main components of Mv-EO were pulegone (64.65%) and menthone (23.92%). There was no mortality, adverse effects on general conditions or changes in body weight, food consumption and feed conversion efficiency throughout the study in male and female rats. Subchronic administration of Mv-EO did not alter the weights, morphological and histopathological analyses of liver, kidney and intestine. Genotoxicity was tested by micronucleus and comet assays. Mv-EO up to a concentration of 7 g/kg feed for 90 days did not exert a cyto-genotoxic effect on the bone marrow and cells blood of Wistar rats. These results suggest that Mv-EO appears to be safe and could be devoid of any toxic risk.

  2. Vertical jump performance after 90 days bed rest with and without flywheel resistive exercise, including a 180 days follow-up.

    PubMed

    Rittweger, Jörn; Felsenberg, Dieter; Maganaris, Constantinos; Ferretti, José Luis

    2007-07-01

    Muscle atrophy and neuromuscular de-conditioning occur in response to space flight and bed-rest. In this study, we investigated the efficacy of flywheel training to conserve jumping power and height during 90 days bed rest. Twenty-four young healthy men underwent strict bed-rest (-6 degrees head down tilt) for 90 days. Eight participants were assigned to a flywheel group (FW) and 16 to a control group (Ctrl). The ground reaction force was measured during vertical jump tests twice during baseline data collection, and on day 4, 7, 14, 90 and 180 of recovery. In half of the participants, jump tests were also performed within minutes after re-ambulation and on four more occasions during the first 2 days of recovery. Jump height was reduced from 40.6 cm (SD 6.1 cm) during the first baseline measurement to 27.6 cm (SD 5.6 cm) on day 4 of recovery in Ctrl, but only from 38.6 cm (SD 3.9 cm) to 34.4 cm (SD 6.5 cm) in FW (P < 0.001). At the same time, peak power was reduced from 47.4 W/kg (SD 8.0 W/kg) to 34.5 W/kg in Ctrl, but only from 46.2 W/kg (6.0 W/kg) to 42.2 W/kg SD 4.6 W/kg) in FW (P < 0.001). Jump height and peak power were completely recovered after 163 and 140 days in Ctrl, respectively, and after 72 and 18 days in FW (regression analysis). In conclusion, flywheel exercise could effectively offset neuromuscular de-conditioning during bed-rest, and led to full recovery at an earlier stage. These findings nourish the hope that adequate training paradigms can fully sustain neuromuscular function under microgravity conditions.

  3. Training and certification program of the operating staff for a 90-day test of a regenerative life support system

    NASA Technical Reports Server (NTRS)

    1972-01-01

    Prior to beginning a 90-day test of a regenerative life support system, a need was identified for a training and certification program to qualify an operating staff for conducting the test. The staff was responsible for operating and maintaining the test facility, monitoring and ensuring crew safety, and implementing procedures to ensure effective mission performance with good data collection and analysis. The training program was designed to ensure that each operating staff member was capable of performing his assigned function and was sufficiently cross-trained to serve at certain other positions on a contingency basis. Complicating the training program were budget and schedule limitations, and the high level of sophistication of test systems.

  4. Dietary and Food Processing for a 90-day Bioregenerative Life Support Experiment in the Lunar Palace 1

    NASA Astrophysics Data System (ADS)

    Zhao, Zhiruo; Fu, Yuming; Dong, Chen; Liu, Guanghui

    A 4-day cycle dietary menu was developed to meet the requirements of balanced diet of the crew within the 90-day closed experiment of bioregenerative life support in the Lunar Palace 1. The menu consisted of items prepared from crops and insect grown inside the system, as well as prestored food. Dairy recipe was composed of breads, vegetables, meats and soups, which provided about 2900 kcal per crew member per day. During food processing, to maximize nutrient recovery and minimize waste production, the whole wheat grains and chufa nuts were milled. Further, the carrot leaves and yellow mealworms were used as salad materials and bread ingredients, respectively. The sensory acceptability of the dishes in the menu was evaluated by flavor, texture, and appearance. Our results show that all dishes in the 4-day cycle menu were highly acceptable, which satisfies nutritional requirement of the crew members in the closed habitation.

  5. Evaluation of 90 day repeated dose oral toxicity and reproductive/developmental toxicity of 3'-hydroxypterostilbene in experimental animals

    PubMed Central

    Majeed, Muhammed; Bani, Sarang; Natarajan, Sankaran; Pandey, Anjali; S, Naveed

    2017-01-01

    3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium. Despite many proposed therapeutic applications, the safety profile of 3'-HPT has not been established. The present work investigated 90 day repeated oral dose and reproductive (developmental) toxicity of 3'-HPT as a test substance in rats as per OECD guidelines. 90 day toxicity was conducted in sixty Sprague Dawley rats of each sex (120 rats), grouped into six dosage groups of 0 (control), 0 (control recovery), 20 (low dose), 80 (mid dose), 200 (high dose) and 200 (high dose recovery) mg/kg bwt/day (body weight/day) respectively. For the reproductive toxicity study forty Wistar rats of each sex (80 rats) divided into four dosage groups received 0 (vehicle control), 20 (low dose), 100 (mid dose) and 200 (high dose) mg/kg bwt/day of 3'-HPT respectively for a period of two weeks while pre-mating, mating, on the day before sacrifice, in females during pregnancy and four days of lactation period. Results showed no significant differences in body weight, food intake, absolute organ weight, haematology, with no adverse effects (toxicity) on biochemical values nor any abnormal clinical signs or behavioural changes were observed in any of the control/treatment groups, including reproductive and developmental parameters, gross and histopathological changes. In conclusion, the results suggested a No-Observed-Adverse-Effect-Level (NOAEL) of 200 mg/kg bwt/day in rats after oral administration, implying 3'-HPT did not exhibit any toxicity under the study conditions employed. PMID:28257483

  6. Evaluation of 90 day repeated dose oral toxicity and reproductive/developmental toxicity of 3'-hydroxypterostilbene in experimental animals.

    PubMed

    Majeed, Muhammed; Bani, Sarang; Natarajan, Sankaran; Pandey, Anjali; S, Naveed

    2017-01-01

    3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium. Despite many proposed therapeutic applications, the safety profile of 3'-HPT has not been established. The present work investigated 90 day repeated oral dose and reproductive (developmental) toxicity of 3'-HPT as a test substance in rats as per OECD guidelines. 90 day toxicity was conducted in sixty Sprague Dawley rats of each sex (120 rats), grouped into six dosage groups of 0 (control), 0 (control recovery), 20 (low dose), 80 (mid dose), 200 (high dose) and 200 (high dose recovery) mg/kg bwt/day (body weight/day) respectively. For the reproductive toxicity study forty Wistar rats of each sex (80 rats) divided into four dosage groups received 0 (vehicle control), 20 (low dose), 100 (mid dose) and 200 (high dose) mg/kg bwt/day of 3'-HPT respectively for a period of two weeks while pre-mating, mating, on the day before sacrifice, in females during pregnancy and four days of lactation period. Results showed no significant differences in body weight, food intake, absolute organ weight, haematology, with no adverse effects (toxicity) on biochemical values nor any abnormal clinical signs or behavioural changes were observed in any of the control/treatment groups, including reproductive and developmental parameters, gross and histopathological changes. In conclusion, the results suggested a No-Observed-Adverse-Effect-Level (NOAEL) of 200 mg/kg bwt/day in rats after oral administration, implying 3'-HPT did not exhibit any toxicity under the study conditions employed.

  7. Safety assessment of genetically modified milk containing human beta-defensin-3 on rats by a 90-day feeding study.

    PubMed

    Chen, Xin; Gao, Ming-Qing; Liang, Dong; Yin, Songna; Yao, Kezhen; Zhang, Yong

    2017-02-01

    In recent years, transgenic technology has been widely applied in many fields. There is concern about the safety of genetically modified (GM) products with the increased prevalence of GM products. In order to prevent mastitis in dairy cows, our group produced transgenic cattle expressing human beta-defensin-3 (HBD3) in their mammary glands, which confers resistance to the bacteria that cause mastitis. The milk derived from these transgenic cattle thus contained HBD3. The objective of the present study was to analyze the nutritional composition of HBD3 milk and conduct a 90-day feeding study on rats. Rats were divided into 5 groups which consumed either an AIN93G diet (growth purified diet for rodents recommended by the American Institute of Nutrition) with the addition of 10% or 30% HBD3 milk, an AIN93G diet with the addition of 10% or 30% conventional milk, or an AIN93G diet alone. The results showed that there was no difference in the nutritional composition of HBD3 and conventional milk. Furthermore, body weight, food consumption, blood biochemistry, relative organ weight, and histopathology were normal in those rats that consumed diets containing HBD3. No adverse effects were observed between groups that could be attributed to varying diets or gender.

  8. An estimate of equatorial wave energy flux at 9- to 90-day periods in the Central Pacific

    NASA Technical Reports Server (NTRS)

    Eriksen, Charles C.; Richman, James G.

    1988-01-01

    Deep fluctuations in current along the equator in the Central Pacific are dominated by coherent structures which correspond closely to narrow-band propagating equatorial waves. Currents were measured roughly at 1500 and 3000 m depths at five moorings between 144 and 148 deg W from January 1981 to March 1983, as part of the Pacific Equatorial Ocean Dynamics program. In each frequency band resolved, a single complex empirical orthogonal function accounts for half to three quarters of the observed variance in either zonal or meridional current. Dispersion for equatorial first meridional Rossby and Rossby gravity waves is consistent with the observed vertical-zonal coherence structure. The observations indicate that energy flux is westward and downward in long first meridional mode Rossby waves at periods 45 days and longer, and eastward and downward in short first meridional mode Rossby waves and Rossby-gravity waves at periods 30 days and shorter. A local minimum in energy flux occurs at periods corresponding to a maximum in upper-ocean meridional current energy contributed by tropical instability waves. Total vertical flux across the 9- to 90-day period range is 2.5 kW/m.

  9. Anatomical sector analysis of load-bearing tibial bone structure during 90-day bed rest and 1-year recovery.

    PubMed

    Cervinka, Tomas; Rittweger, Jörn; Hyttinen, Jari; Felsenberg, Dieter; Sievänen, Harri

    2011-07-01

    The aim of this study was to investigate whether the bone response to long bed rest-related immobility and during subsequent recovery differed at anatomically different sectors of tibial epiphysis and diaphysis. For this study, peripheral quantitative tomographic (pQCT) scans obtained from a previous 90-day 'Long Term Bed Rest' intervention were preprocessed with a new method based on statistical approach and re-analysed sector-wise. The pQCT was performed on 25 young healthy males twice before the bed rest, after the bed rest and after 1-year follow-up. All men underwent a strict bed rest intervention, and in addition, seven of them received pamidronate treatment and nine did flywheel exercises as countermeasures against disuse-related bone loss. Clearly, 3-9% sector-specific losses in trabecular density were observed at the tibial epiphysis on average. Similarly, cortical density decreased in a sector-specific way being the largest at the anterior sector of tibial diaphysis. During recovery, the bed rest-induced bone losses were practically restored and no consistent sector-specific modulation was observed in any subgroup. It is concluded that the sector-specific analysis of bone cross-sections has potential to reveal skeletal responses to various interventions that cannot be inferred from the average analysis of the whole bone cross-section. This approach is considered also useful for evaluating the bone responses from the biomechanical point of view.

  10. Results of a 90-day safety assurance study with rats fed grain from corn rootworm-protected corn.

    PubMed

    Hammond, B; Lemen, J; Dudek, R; Ward, D; Jiang, C; Nemeth, M; Burns, J

    2006-02-01

    The results of a 90-day rat feeding study with YieldGard (YieldGard Rootworm Corn is a registered trademark of Monsanto Technology, LLC.) Rootworm corn (MON 863) grain that is protected against feeding damage caused by corn rootworm larvae are presented. Corn rootworm-protection was accomplished through the introduction of a cry3Bb1 coding sequence into the corn genome for in planta production of a modified Cry3Bb1 protein from Bacillus thuringiensis. Grain from MON 863 and its near isogenic control were separately formulated into rodent diets at levels of 11% and 33% (w/w) by Purina Mills, Inc. Additionally, six groups of rats were fed diets containing grain from different conventional (non-biotechnology-derived) reference varieties. The responses of rats fed diets containing MON 863 were compared to those of rats fed grain from conventional corn varieties. All diets were nutritionally balanced and conformed to Purina Mills, Inc. specifications for Certified LabDiet 5002. There were a total of 400 rats in the study divided into 10 groups of 20 rats/sex/group. Overall health, body weight gain, food consumption, clinical pathology parameters (hematology, blood chemistry, urinalysis), organ weights, gross and microscopic appearance of tissues were comparable between groups fed diets containing MON 863 and conventional corn varieties. This study complements extensive agronomic, compositional and farm animal feeding studies with MON 863 grain, confirming that it is as safe and nutritious as existing conventional corn varieties.

  11. Results of a 90-day safety assurance study with rats fed grain from corn borer-protected corn.

    PubMed

    Hammond, B G; Dudek, R; Lemen, J K; Nemeth, M A

    2006-07-01

    The results of a 90-day rat feeding study with grain from MON 810 corn (YieldGard Cornborer -- YieldGard Cornborer is a registered trademark of Monsanto Technology, LLC) that is protected against feeding damage from corn and stalk boring lepidopteran insects are presented. Corn borer protection was accomplished through the introduction of cry1Ab coding sequences into the corn genome for in planta production of a bioactive form of Cry1Ab protein. Grain from MON 810 and its near-isogenic control was separately formulated into rodent diets at levels of 11% and 33% (w/w) by Purina Mills, Inc. (PMI). All diets were nutritionally balanced and conformed to PMI specifications for Certified LabDiet (PMI Certified LabDiet 5002 is a registered trademark of Purina Mills, Inc.) 5002. There were a total of 400 rats in the study divided into 10 groups of 20 rats/sex/group. The responses of rats fed diets containing MON 810 were compared to those of rats fed grain from conventional corn varieties. Overall health, body weight, food consumption, clinical pathology parameters (hematology, blood chemistry, urinalysis), organ weights, and gross and microscopic appearance of tissues were comparable between groups fed diets containing MON 810 and conventional corn varieties. This study complements extensive agronomic, compositional and farm animal feeding studies with MON 810 grain, confirming that it is as safe and nutritious as grain from existing commercial corn varieties.

  12. A 90-day subchronic feeding study of genetically modified rice expressing Cry1Ab protein in Sprague-Dawley rats.

    PubMed

    Song, Huan; He, Xiaoyun; Zou, Shiying; Zhang, Teng; Luo, Yunbo; Huang, Kunlun; Zhu, Zhen; Xu, Wentao

    2015-04-01

    Bacillus thuringiensis (Bt) transgenic rice line (mfb-MH86) expressing a synthetic cry1Ab gene can be protected against feeding damage from Lepidopteran insects, including Sesamia inferens, Chilo suppressalis, Tryporyza incertulas and Cnaphalocrocis medinalis. Rice flour from mfb-MH86 and its near-isogenic control MH86 was separately formulated into rodent diets at concentrations of 17.5, 35 and 70 % (w/w) for a 90-day feeding test with rats, and all of the diets were nutritionally balanced. In this study, the responses of rats fed diets containing mfb-MH86 were compared to those of rats fed flour from MH86. Overall health, body weight and food consumption were comparable between groups fed diets containing mfb-MH86 and MH86. Blood samples were collected prior to sacrifice and a few significant differences (p < 0.05) were observed in haematological and biochemical parameters between rats fed genetically modified (GM) and non-GM diets. However, the values of these parameters were within the normal ranges of values for rats of this age and sex, thus not considered treatment related. In addition, upon sacrifice a large number of organs were weighed, macroscopic and histopathological examinations were performed with only minor changes to report. In conclusion, these results demonstrated that no toxic effect was observed in the conditions of the experiment, based on the different parameters assessed. GM rice mfb-MH86 is as safe and nutritious as non-GM rice.

  13. A 90-day study of sub-chronic oral toxicity of 20 nm positively charged zinc oxide nanoparticles in Sprague Dawley rats

    PubMed Central

    Park, Hark-Soo; Kim, Seon-Ju; Lee, Taek-Jin; Kim, Geon-Yong; Meang, EunHo; Hong, Jeong-Sup; Kim, Su-Hyon; Koh, Sang-Bum; Hong, Seung-Guk; Sun, Yle-Shik; Kang, Jin Seok; Kim, Yu-Ri; Kim, Meyoung-Kon; Jeong, Jayoung; Lee, Jong-Kwon; Son, Woo-Chan; Park, Jae-Hak

    2014-01-01

    Purpose The study reported here was conducted to determine the systemic oral toxicity and to find the no-observed-adverse-effect level of 20 nm positively charged zinc oxide (ZnOSM20(+)) nanoparticles in Sprague Dawley rats for 90 days. Methods For the 90-day toxicity study, the high dose was set as 500 mg per kg of body weight (mg/kg) and the middle and low dose were set to 250 mg/kg and 125 mg/kg, respectively. The rats were held for a 14-day recovery period after the last administration, to observe for the persistence or reduction of any toxic effects. A distributional study was also carried out for the systemic distribution of ZnOSM20(+) NPs. Results No rats died during the test period. There were no significant clinical changes due to the test article during the experimental period in functional assessment, body weight, food and water consumption, ophthalmological testing, urine analysis, necropsy findings, or organ weights, but salivation was observed immediately after administration in both sexes. The total red blood cell count was increased, and hematocrit, albumin, mean cell volume, mean cell hemoglobin, and mean cell hemoglobin concentration were decreased significantly compared with control in both 500 mg/kg groups. Total protein and albumin levels were decreased significantly in both sexes in the 250 and 500 mg/kg groups. Histopathological studies revealed acinar cell apoptosis in the pancreas, inflammation and edema in stomach mucosa, and retinal atrophy of the eye in the 500 mg/kg group. Conclusion There were significant parameter changes in terms of anemia in the hematological and blood chemical analyses in the 250 and 500 mg/kg groups. The significant toxic change was observed to be below 125 mg/kg, so the no-observed-adverse-effect level was not determined, but the lowest-observed-adverse-effect level was considered to be 125 mg/kg in both sexes and the target organs were found to be the pancreas, eye, and stomach. PMID:25565829

  14. Safety assessment of freeze-dried powdered Tenebrio molitor larvae (yellow mealworm) as novel food source: Evaluation of 90-day toxicity in Sprague-Dawley rats.

    PubMed

    Han, So-Ri; Lee, Byoung-Seok; Jung, Kyung-Jin; Yu, Hee-Jin; Yun, Eun-Young; Hwang, Jae Sam; Moon, Kyoung-Sik

    2016-06-01

    Worldwide demand for novel food source has grown and edible insects are a promising food sources for humans. Tenebrio molitor, as known as yellow mealworm, has advantages of being rich in protein, and easy to raise as a novel food source. The objective of this study was to evaluate subchronic toxicity, including potential hypersensitivity, of freeze-dried powdered T. molitor larvae (fdTML) in male and female Sprague-Dawley rats. The fdTML was administered orally once daily at dose levels of 0, 300, 1000 and 3000 mg/kg/day for 90 days. A toxicological assessment was performed, which included mortality, clinical signs, body and organ weights, food consumption, ophthalmology, urinalysis, hematology, serum chemistry, gross findings, histopathologic examination and allergic reaction. There were no fdTML- related findings in clinical signs, urinalysis, hematology and serum chemistry, gross examination, histopathologic examination or allergic reaction. In conclusion, the No Observed Adverse Effect Level (NOAEL) for fdTML was determined to be in excess of 3000 mg/kg/day in both sexes of rats under the experimental conditions of this study.

  15. Report of an Expert Panel on the reanalysis by of a 90-day study conducted by Monsanto in support of the safety of a genetically modified corn variety (MON 863).

    PubMed

    Doull, J; Gaylor, D; Greim, H A; Lovell, D P; Lynch, B; Munro, I C

    2007-11-01

    MON 863, a genetically engineered corn variety that contains the gene for modified Bacillus thuringiensis Cry3Bb1 protein to protect against corn rootworm, was tested in a 90-day toxicity study as part of the process to gain regulatory approval. This study was reanalyzed by Séralini et al. who contended that the study showed possible hepatorenal effects of MON 863. An Expert Panel was convened to assess the original study results as analyzed by the Monsanto Company and the reanalysis conducted by Séralini et al. The Expert Panel concludes that the Séralini et al. reanalysis provided no evidence to indicate that MON 863 was associated with adverse effects in the 90-day rat study. In each case, statistical findings reported by both Monsanto and Séralini et al. were considered to be unrelated to treatment or of no biological or clinical importance because they failed to demonstrate a dose-response relationship, reproducibility over time, association with other relevant changes (e.g., histopathology), occurrence in both sexes, difference outside the normal range of variation, or biological plausibility with respect to cause-and-effect. The Séralini et al. reanalysis does not advance any new scientific data to indicate that MON 863 caused adverse effects in the 90-day rat study.

  16. Calf venous volume during stand-test after a 90-day bed-rest study with or without exercise countermeasure

    PubMed Central

    de Chantemèle, Eric Belin; Pascaud, Ludovic; Custaud, Marc-Antoine; Capri, Arnaud; Louisy, Francis; Ferretti, Guido; Gharib, Claude; Arbeille, Philippe

    2004-01-01

    The objectives to determine both the contribution to orthostatic intolerance (OI) of calf venous volume during a stand-test, and the effects of a combined eccentric–concentric resistance exercise countermeasure on both vein response to orthostatic test and OI, after 90-day head-down tilt bed-rest (HDT). The subjects consisted of a control group (Co-gr, n = 9) and an exercise countermeasure group (CM-gr, n = 9). Calf volume and vein cross-sectional area (CSA) were assessed by plethysmography and echography during pre- and post-HDT stand-tests. From supine to standing (post-HDT), the tibial and gastronemius vein CSA increased significantly in intolerant subjects (tibial vein, +122% from pre-HDT; gastronemius veins, +145%; P < 0.05) whereas it did not in tolerant subjects. Intolerant subjects tended to have a higher increase in calf filling volume than tolerant subjects, in both sitting and standing positions. The countermeasure did not reduce OI. Absolute calf volume decreased similarly in both groups. Tibial and gastrocnemius vein CSA at rest did not change during HDT in either group. During the post-HDT stand-test, the calf filling volume increased more in the CM-gr than in the Co-gr both in the sitting (+1.3 ± 5.1%, vs.–7.3 ± 4.3%; P < 0.05) and the standing positions (+56.1 ± 23.7%vs.+1.6 ± 9.6%; P < 0.05). The volume ejected by the muscle venous pump increased only in the CM-gr (+38.3 ± 21.8%). This study showed that intolerant subjects had a higher increase in vein CSA in the standing position and a tendency to present a higher calf filling volume in the sitting and standing positions. It also showed that a combined eccentric–concentric resistance exercise countermeasure had no effects on either post-HDT OI or on the venous parameters related to it. PMID:15331681

  17. 78 FR 33790 - Endangered and Threatened Wildlife and Plants; 12-Month Findings on Petitions To Delist U.S...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-05

    ...). Based on our review, we find that delisting the U.S. captive animals or U.S. captive-bred members of...- bred live animals, including embryos and gametes, and sport-hunted trophies, and would authorize, under... U.S. captive-bred animals of these three species, as described above. The promulgation of...

  18. Toxicity studies on Agents GB and GD (Phase 2): 90-day subchronic study of GB (Sarin, Type I) in CD rats. Final report, Jul 85-Aug 91

    SciTech Connect

    Bucci, T.J.; Parker, R.M.; Crowell, J.A.; Thurman, J.D.; Gosnell, P.A.

    1991-08-01

    A two-phase Dose Range finding study and a 90-Day Subchronic study were conducted in CD rats using the organophosphate ester Sarin (Agent GB, Type I, CAS Number 107-44-8). The highest dose level without lethality in the second phase of the range finding study was designated the maximum tolerated dose (MTD). The doses selected for the subchronic study were the MTD (300 micron GBI/Kg/day), MTD/2 (150, micron GBI/Kg/day), MTD/4 (75 micron GBI/Kg/day), and a vehicle control (O micron /Kg/day). Forty-eight male and forty-eight female CD rats were randomly allocated at 11-12 weeks of age into four treatment groups (12 per sex per group). The animals were gavaged Monday through Friday for 13 weeks and euthanized with carbon dioxide at the beginning of the fourteenth week. Animals were observed daily for clinical signs of toxicity and were weighed weekly. The rats were bled (6 rats/sex/dose) during weeks -1, 1, 3, 7, and at necropsy. Necropsy examination was performed on all animals. Microscopic evaluation was performed on all high-dose and control animals, and on those tissues of lower dose animals that were abnormal at necropsy. All gross lesions and all animals dying or removed early received histological examination. A cause of death or morbidity for animals removed before the end of the study, determined from histopathological examination, was established in four of the eight cases. There were several statistically significant effects in the clinical chemistry and hematology data. These effects were scattered among the treatment groups and were not numerous enough to develop a pattern of organ toxicity.

  19. Vancomycin MIC Does Not Predict 90-Day Mortality, Readmission, or Recurrence in a Prospective Cohort of Adults with Staphylococcus aureus Bacteremia

    PubMed Central

    Clemenzi-Allen, Angelo; Gahbauer, Alice; Deck, Daniel; Imp, Brandon; Vittinghoff, Eric; Chambers, Henry F.; Doernberg, Sarah

    2016-01-01

    Staphylococcus aureus bacteremia (SAB) is a tremendous health burden. Previous studies examining the association of vancomycin MIC and outcomes in patients with SAB have been inconclusive. This study evaluated the association between vancomycin MICs and 30- or 90-day mortality in individuals with SAB. This was a prospective cohort study of adults presenting from 2008 to 2013 with a first episode of SAB. Subjects were identified by an infection surveillance system. The main predictor was vancomycin MIC by MicroScan. The primary outcomes were death at 30 and 90 days, and secondary outcomes included recurrence, readmission, or a composite of death, recurrence, and readmission at 30 and 90 days. Covariates included methicillin susceptibility, demographics, illness severity, comorbidities, infectious source, and antibiotic use. Cox proportional-hazards models with propensity score adjustment were used to estimate 30- and 90-day outcomes. Of 429 unique first episodes of SAB, 11 were excluded, leaving 418 individuals for analysis. Eighty-three (19.9%) participants had a vancomycin MIC of 2 μg/ml. In the propensity-adjusted Cox model, a vancomycin MIC of 2 μg/ml compared to <2 μg/ml was not associated with a greater hazard of mortality or composite outcome of mortality, readmission, and recurrence at either 30 days (hazard ratios [HRs] of 0.86 [95% confidence interval {CI}, 0.41, 1.80] [P = 0.70] and 0.94 [95% CI, 0.55, 1.58] [P = 0.80], respectively) or 90 days (HRs of 0.91 [95% CI, 0.49, 1.69] [P = 0.77] and 0.69 [95% CI, 0.46, 1.04] [P = 0.08], respectively) after SAB diagnosis. In a prospective cohort of patients with SAB, vancomycin MIC was not associated with 30- or 90-day mortality or a composite of mortality, disease recurrence, or hospital readmission. PMID:27324762

  20. Toxicity studies on Agents GB and GD (Phase 2): 90-day subchronic study of GB (Sarin, Type II) in CD rats. Final report, Jul 85-Aug 91

    SciTech Connect

    Bucci, T.J.; Parker, R.M.

    1992-01-01

    A two-phase Dose Range findng study and a 90-Day Subchronic study were conducted in CD rats using the organophosphate ester Sarin (Agent GB, Type II, CAS Number 107-44-8). The highest dose level without lethality in the second phase of the range finding study was designated the maximum tolerated dose (MTD). The doses selected for the subchronic study were the MTD (300 micron GBII/Kg/day), MTD/2 (150micron GBII/Kg/day), MTD/4 (75micron GBII/Kg/day), and a vehicle control . Forty-eight male and forty-eight female CD rats were randomly allocated at 11 -1 2 weeks of age into four treatment groups (1 2 per sex per group). The animals were gavaged Monday through Friday for 13 weeks and euthanized with carbon dioxide at the beginning of the fourteenth week. Animals were observed daily for clinical signs of toxicity and were weighed weekly. The rats were bled (6 rat/sex/dose) during weeks -1, 1, 3, 7, and at necropsy. Necropsy examination was performed on all animals. Microscopic evaluation was performed on all high-dose and control animals and on those tissues of lower dose animals that were abnormal at necropsy. All gross lesions and all animals dying or removed early received histological examination. A cause of death or morbidity for animals removed before the end of the study, determined from histopathological examination, was established in four cases. There were several statistically significant effects in the clinical chemistry and hematology data. These effects were scattered among the treatment groups and were not numerous enough to develop a pattern of organ toxicity.

  1. Results of a 90-day toxicity study on 1,2,3- and 1,1,2-trichloropropane administered via the drinking water.

    PubMed

    Villeneuve, D C; Chu, I; Secours, V E; Coté, M G; Plaa, G L; Valli, V E

    1985-12-01

    Trichloropropanes have been identified as environmental contaminants in sediments of the Great Lakes region of North America. Since these chemicals had the potential to find their way into drinking water, a 90-day feeding study was carried out in order to determine their subchronic toxicity. Groups of 10 male and 10 female weanling Sprague-Dawley rats were supplied drinking water ad libitum, containing 1,2,3- or 1,1,2-trichloropropane at concentrations of 1, 10, 100 or 1000 mg/L for 13 weeks. Emulphor (0.5%) was used to solubilize the chemicals. At the end of the study, the animals were killed and examined for gross and microscopic changes. Heart, liver, brain, kidney and spleen were excised and weighed. Blood was collected and subjected to a comprehensive hematological analysis. Serum was collected and profiled for changes in 12 biochemical parameters and a portion of liver was used to determined mixed function oxidase activity. Although three animals died during the study, their deaths could not be related to treatment. Decreased growth rate was observed in both sexes of the group receiving 1000 mg/L 1,2,3-trichloropropane. There was an increase in liver, kidney and brain weights (relative to body weight) in rats of both sexes fed 1000 mg/L 1,2,3-trichloropropane. Fatty livers were observed in some of the treated animals but a clear dose-relationship was not evident. An elevation in serum cholesterol was observed in female rats fed the highest dose of 1,2,3-trichloropropane.(ABSTRACT TRUNCATED AT 250 WORDS)

  2. 7 CFR Appendix B to Subpart C of... - FSA-2510, Notice of Availability of Loan Servicing to Borrowers Who Are 90 Days Past Due

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false FSA-2510, Notice of Availability of Loan Servicing to Borrowers Who Are 90 Days Past Due B Appendix B to Subpart C of Part 766 Agriculture Regulations of the... LOAN SERVICING-SPECIAL Loan Servicing Programs Pt. 766, Subpt. C, App. B Appendix B to Subpart C...

  3. 7 CFR Appendix B to Subpart C of... - FSA-2510, Notice of Availability of Loan Servicing to Borrowers Who Are 90 Days Past Due

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 7 2011-01-01 2011-01-01 false FSA-2510, Notice of Availability of Loan Servicing to Borrowers Who Are 90 Days Past Due B Appendix B to Subpart C of Part 766 Agriculture Regulations of the... LOAN SERVICING-SPECIAL Loan Servicing Programs Pt. 766, Subpt. C, App. B Appendix B to Subpart C...

  4. IN VIVO EVALUATION OF THE SEALING ABILITY OF TWO ENDODONTIC SEALERS IN ROOT CANALS EXPOSED TO THE ORAL ENVIRONMENT FOR 45 AND 90 DAYS

    PubMed Central

    Kopper, Patrícia Maria Poli; Vanni, José Roberto; Della Bona, Álvaro; de Figueiredo, José Antônio Poli; Porto, Sérgio

    2006-01-01

    This in vivo study evaluated the sealing ability of a resin-based sealer (AH Plus) and a zinc oxide-eugenol sealer (Endofill) in dogs' teeth, exposed to the oral environment for 45 and 90 days. Forty eight lower incisors from 8 dogs were endodonticaly treated. A stratified randomization determined the sealer use in each root canal. All canals were filled using the lateral condensation technique. The excess filling material at the cervical portion of the root canal was sectioned, leaving a 10-mm obturation length inside the canal. Teeth were provisionally sealed with glass ionomer cement for 24 h and the canals were exposed to the oral environment for either 45 or 90 days. Therefore, the experimental groups were as follows: A45- AH Plus for 45 days; A90- AH Plus for 90 days; E45- Endofill for 45 days; and E90- Endofill for 90 days (n=12). After the experimental period, the dogs were killed and the lower jaw was removed. The incisors were extracted and the roots were covered with two coats of nail varnish. The teeth were immersed in India ink for 96 h and submitted to diaphanization. Dye leakage (in mm) was measured using stereomicroscopy (10x magnification). The results were statistically analyzed using two-way ANOVA and Tukey test for multiple comparisons (á = 0.05). Group E90 (2.03±0.94) showed significantly higher mean leakage value than all other groups (p<0.001). None of the sealers, in both study conditions, were able to prevent dye leakage. PMID:19089029

  5. Toxicity studies on agent GA (Phase 2): 90 day subchronic study of GA (Tabun) in cd rats. Appendices. Final report, July 1985-August 1991

    SciTech Connect

    Not Available

    1992-03-01

    The purpose of the report is to provide essential toxicologic information on Tabun administration over a 90 day period. This toxicologic information may be used to adjust the maximum-tolerated dose for subsequent dominant-lethal and two-generation reproduction studies. The objectives were to determine the toxic effects of nerve agent exposure (e.g., target organs); and to determine the effects of nerve agent GA on sperm morphology and motility and vaginal cytology.

  6. Vitamin D deficiency at admission is not associated with 90-day mortality in patients with severe sepsis or septic shock: Observational FINNAKI cohort study.

    PubMed

    Ala-Kokko, Tero I; Mutt, Shivaprakash J; Nisula, Sara; Koskenkari, Juha; Liisanantti, Janne; Ohtonen, Pasi; Poukkanen, Meri; Laurila, Jouko J; Pettilä, Ville; Herzig, Karl-Heinz

    2016-01-01

    Introduction Low levels of vitamin D have been associated with increased mortality in patients that are critically ill. This study explored whether vitamin D levels were associated with 90-day mortality in severe sepsis or septic shock. Methods Plasma vitamin D levels were measured on admission to the intensive care unit (ICU) in a prospective multicentre observational study. Results 610 patients with severe sepsis were included; of these, 178 (29%) had septic shock. Vitamin D deficiency (<50 nmol/L) was present in 333 (55%) patients. The 90-day mortality did not differ among patients with or without vitamin D deficiency (28.3% vs. 28.5%, p = 0.789). Diabetes was more common among patients deficient compared to those not deficient in vitamin D (30% vs. 18%, p < 0.001). Hospital-acquired infections at admission were more prevalent in patients with a vitamin D deficiency (31% vs. 16%, p < 0.001). A multivariable adjusted Cox regression model showed that low vitamin D levels could not predict 90-day mortality (<50 nmol/L: hazard ratio (HR) 0.99 (95% CI: 0.72-1.36), p > 0.9; and <25 nmol/L: HR 0.44 (95% CI: 0.22-0.87), p = 0.018). Conclusions Vitamin D deficiency detected upon ICU admission was not associated with 90-day mortality in patients with severe sepsis or septic shock. Key messages In severe sepsis and septic shock, a vitamin D deficiency upon ICU admission was not associated with increased mortality. Compared to patients with sufficient vitamin D, patients with deficient vitamin D more frequently exhibited diabetes, elevated C-reactive protein levels, and hospital-acquired infections upon ICU admission, and they more frequently developed acute kidney injury.

  7. Muscle atrophy and bone loss after 90 days' bed rest and the effects of flywheel resistive exercise and pamidronate: results from the LTBR study.

    PubMed

    Rittweger, Jörn; Frost, Harold M; Schiessl, Hans; Ohshima, Hiroshi; Alkner, Björn; Tesch, Per; Felsenberg, Dieter

    2005-06-01

    Muscle atrophy and bone loss pose substantial problems for long-term space flight and in clinical immobilization. We therefore tested the efficacy of flywheel resistive exercise and pamidronate to counteract such losses. Twenty five young healthy males underwent strict bed rest with -6 degrees head-down tilt for 90 days. Subjects were randomized into an exercise group that practiced resistive exercise with a 'flywheel' (FW) device every 2-3 days, a pamidronate group (Pam) that received 60 mg pamidronate i.v. 14 days prior to bed rest and a control group (Ctrl) that received none of these countermeasures. During the study, Ca(++) and protein intake were controlled. Peripheral quantitative computed tomography (pQCT) was used to assess bone mineral content (BMC) and muscle cross sectional area (mCSA) of calf and forearm. Measurements were taken twice during baseline data collection, after 28 and after 89 days bed rest, and after 14 days recovery. On the same days, urinary Pyridinoline excretion and serum levels of alkaline phosphatase, Ca(++) and PTH were measured. Pre-study exercise habits were assessed through the Freiburg questionnaire. Losses in calf mCSA were significantly reduced in FW (Ctrl: -25.6% +/- 2.5% Pam: -25.6% +/- 3.7%, FW: -17.3% +/- 2.7%), but not in the forearm mCSA (Ctrl: -6.4% +/- 4.33%, Pam: -7.7% +/- 4.1%, FW: -7.6% +/- 3.3%). Both diaphyseal and epiphyseal BMC losses of the tibia were mitigated in Pam and FW as compared to Ctrl, although this was significant only at the diaphysis. Inter-individual variability was significantly greater for changes in BMC than in mCSA, and correlation of BMC losses was poor among different locations of the tibia. A significant positive correlation was found between change in tibia epiphyseal BMC and serum cortisol levels. These findings suggest that both countermeasures are only partly effective to preserve BMC (FW and Pam) and mCSA (FW) of the lower leg during bed rest. The partial efficacy of flywheel exercise

  8. A 90-day safety study of genetically modified rice expressing rhIGF-1 protein in C57BL/6J rats.

    PubMed

    Tang, Maoxue; Xie, Tingting; Cheng, Wenke; Qian, Lili; Yang, Shulin; Yang, Daichang; Cui, Wentao; Li, Kui

    2012-06-01

    Genetically modified plants expressing disease resistance traits offer new treatment strategies for human diseases, but at the same time present a challenge in terms of food safety assessment. The present 90-day feeding study was designed to assess the safety of transgenic rice expressing the recombinant human insulin-like growth factor-1 (rhIGF-1) compared to its parental wild rice. Male and female C57BL/6J rats were given a nutritionally balanced purified diet with 20% transgenic rhIGF-1 rice or 20% parental rice for 90 days. This corresponds to a mean daily rhIGF-1 protein intake of approximately 217.6 mg/kg body weight based on the average feed consumption. In the animal study a range of biological, biochemical, clinical, microbiological and pathological parameters were examined and several significant differences were observed between groups, but none of the effects were considered to be adverse. In conclusion, no adverse or toxic effects on C57BL/6J rats were observed in the design used in this 90-day study. These results will provide valuable information for the safety assessment of genetically modified food crops.

  9. Influence of CO2 change during 90-day experiment on growth characteristics and photosynthetic activity in vegetables grown in Lunar Palace 1

    NASA Astrophysics Data System (ADS)

    Shao, Lingzhi; Liu, Hong; Wang, Minjuan; Fu, Yuming; Dong, Chen; Liu, Guanghui

    To establish bioregenerative life support system (BLSS) on lunar or Mars bases in the future, it is necessary to firstly conduct manned simulation experiments on the ground. For this purpose, Lunar palace 1 as an integrative experimental facility for permanent astrobase life support artificial closed ecosystem was set up, and 90-day experiment was carried out in this system. Vegtables as one of the important plant units, provide various nutrient content for crews in the system, such as vitamin, antioxidants and so on. However, it is not clear yet that how the CO _{2} change during 90-day experiment to affect on growth characteristics and photosynthetic activity in vegtables grown in the system. In this study, red lettuce, red rape, romaine lettuce, and bibb lettuce grown in the system were chosen as the subject investigated. Growth, expressed as dry weight, length of shoot and root, leaf area, was mearsured, and photosynthesis,expressed as net photosynthetic rate, intercellular CO _{2} concentration, chlorophyll contents and fluorescence was analyzed to detemind influence of CO _{2} change during 90-day experiment on growth in vegtables grown in the system.

  10. A 90-day safety study in Sprague-Dawley rats fed milk powder containing recombinant human lactoferrin (rhLF) derived from transgenic cloned cattle.

    PubMed

    Zhou, Cui; Wang, Jian Wu; Huang, Kun Lun; He, XiaoYun; Chen, Xiu Ping; Sun, Hong; Yu, Tian; Che, Hui Lian

    2011-10-01

    Transgenic cloned animals expressing beneficial human nutritional traits offer a new strategy for large-scale production of some kinds of functional substances. In some cases, the required safety testing for genetically modified (GM) foods do not seem appropriate for human food safety, though regulations do not seem to provide alternatives. A 90-day rat feeding study is the core study for the safety assessment of GM foods. The test material in this 90-day study was prepared nonfat milk powder containing recombinant human lactoferrin (rhLF), which was expressed in transgenic cloned cattle. Groups of 10 male and female Sprague-Dawley rats were given a nutritionally balanced purified diet containing 7.5, 15, or 30% transgenic or conventional milk powder for 90 days. A commercial AIN93G diet was used as an additional control group. Clinical, biological, and pathological parameters were compared between groups. The only significant effect of treatment was higher mean ferritin and Fe(+) concentrations for both male and female rats fed the transgenic milk powder diets, as compared to rats fed nontransgenic milk diets or the commercial diet. The results of the present study are consistent with previous research, which indicates that milk powder containing rhLF derived from healthy transgenic cloned cattle is as safe as conventional milk powder.

  11. Comparative safety testing of genetically modified foods in a 90-day rat feeding study design allowing the distinction between primary and secondary effects of the new genetic event.

    PubMed

    Knudsen, Ib; Poulsen, Morten

    2007-10-01

    This article discusses the wider experiences regarding the usefulness of the 90-day rat feeding study for the testing of whole foods from genetically modified (GM) plant based on data from a recent EU-project [Poulsen, M., Schrøder, M., Wilcks, A., Kroghsbo, S., Lindecrona, R.H., Miller, A., Frenzel, T., Danier, J., Rychlik, M., Shu, Q., Emami, K., Taylor, M., Gatehouse, A., Engel, K.-H., Knudsen, I., 2007a. Safety testing of GM-rice expressing PHA-E lectin using a new animal test design. Food Chem. Toxicol. 45, 364-377; Poulsen, M., Kroghsbo, S., Schrøder, M., Wilcks, A., Jacobsen, H., Miller, A., Frenzel, T., Danier, J., Rychlik, M., Shu, Q., Emami, K., Sudhakar, D., Gatehouse, A., Engel, K.-H., Knudsen, I., 2007b. A 90-day safety in Wistar rats fed genetically modified rice expressing snowdrop lectin Galanthus nivalis (GNA). Food Chem. Toxicol. 45, 350-363; Schrøder, M., Poulsen, M., Wilcks, A., Kroghsbo, S., Miller, A., Frenzel, T., Danier, J., Rychlik, M., Emami, K., Gatehouse, A., Shu, Q., Engel, K.-H., Knudsen, I., 2007. A 90-day safety study of genetically modified rice expressing Cry1Ab protein (Bacillus thuringiensis toxin) in Wistar rats. Food Chem. Toxicol. 45, 339-349]. The overall objective of the project has been to develop and validate the scientific methodology necessary for assessing the safety of foods from genetically modified plants in accordance with the present EU regulation. The safety assessment in the project is combining the results of the 90-day rat feeding study on the GM food with and without spiking with the pure novel gene product, with the knowledge about the identity of the genetic change, the compositional data of the GM food, the results from in-vitro/ex-vivo studies as well as the results from the preceding 28-day toxicity study with the novel gene product, before the hazard characterisation is concluded. The results demonstrated the ability of the 90-day rat feeding study to detect the biological/toxicological effects of the

  12. MELD-Na as a prognostic indicator of 30- and 90-day mortality in patients with end-stage liver disease after creation of transjugular intrahepatic portosystemic shunt.

    PubMed

    Ahmed, Rezwan; Santhanam, Prasanna; Rayyan, Yaser

    2015-10-01

    Previous studies have shown that the Model for End-Stage Liver Disease (MELD) score is superior to other liver disease scoring systems to establish optimal candidates for transjugular intrahepatic portosystemic shunt (TIPS) procedure and liver transplantation. Our aim was to compare MELD-Na score with MELD score as a predictor of 30-day as well as 90-day mortality for individuals with end-stage liver disease (ESLD) after creation of TIPS. We performed a chart review on cirrhotic patients who underwent TIPS procedure and documented presence and severity of ascites and hepatic encephalopathy, patient laboratory values, and results from TIPS procedures. We compared continuous variables by Student's t-test for independent samples and categorical variables by χ-test(s). In non-normal distributions, a nonparametric test was used. We performed a logistic regression to determine the effects of several variables and analyzed variable predictors of likelihood of death within 30 and 90 days of TIPS procedure. Of the six predictor variables, only MELD-Na score was a statistically significant predictor of 30- and 90-day mortality following TIPS procedure for ESLD (P=0.028). For each one point increase in MELD-Na score, the odds of death increased by 1.15 times [95% confidence interval (1.02-1.30), P=0.28]. Since hyponatremia may be associated with poor prognostic features of overall health, its incorporation into the MELD scoring system to predict mortality in ESLD after creation of TIPS serves a useful purpose. Our single-center experience suggests that the MELD-Na score is the most effective predictor of survival after TIPS creation.

  13. Predictors of 30-Day Mortality and 90-Day Functional Recovery after Primary Intracerebral Hemorrhage : Hospital Based Multivariate Analysis in 585 Patients

    PubMed Central

    2009-01-01

    Objective The purpose of this study was to identify independent predictors of mortality and functional recovery in patients with primary intracerebral hemorrhage (PICH) and to improve functional outcome in these patients. Methods Data were collected retrospectively on 585 patients with supratentorial PICH admitted to the Stroke Unit at our hospital between 1st January 2004 and the 31st July 2008. Using multivariate logistic regression analysis, the associations between all selected variables and 30-day mortality and 90-day functional recoveries after PICH was evaluated. Results Ninety-day functional recovery was achieved in 29.1% of the 585 patients and 30-day mortality in 15.9%. Age (OR=7.384, p=0.000), limb weakness (OR=6.927, p=0.000), and hematoma volume (OR=5.293, p=0.000) were found to be powerful predictors of 90-day functional recovery. Furthermore, initial consciousness (OR=3.013, p=0.014) hematoma location (lobar, OR=2.653, p=0.003), ventricular extension of blood (OR=2.077, p=0.013), leukocytosis (OR=2.048, p=0.008), alcohol intake (drinker, OR=1.927, p=0.023), and increased serum aminotransferase (OR=1.892, p=0.035) were found to be independent predictors of 90-day functional recovery after PICH. On the other hand, a pupillary abnormality (OR=4.532, p=0.000) and initial unconsciousness (OR=3.362, p=0.000) were found to be independent predictors of 30-day mortality after PICH. Conclusion The predictors of mortality and functional recovery after PICH identified during this analysis may assist during clinical decision-making, when advising patients or family members about the prognosis of PICH and when planning intervention trials. PMID:19609417

  14. STS-90 Day 09 Highlights

    NASA Technical Reports Server (NTRS)

    1998-01-01

    On this ninth day of the STS-90 mission, the sleep period of the flight crew, Cmdr. Richard A. Searfoss, Pilot Scott D. Altman, and Mission Specialists Richard M. Linnehan, Dafydd Rhys Williams and Kathryn P. Hire, and Payload Specialists Jay C. Buckey and James A. Pawelczyk, is interrupted due to problems with equipment that removes carbon dioxide from the cabin atmosphere. Because of this, Columbia's crew went to bed about two hours later than scheduled.

  15. STS-90 Day 04 Highlights

    NASA Technical Reports Server (NTRS)

    1998-01-01

    On this forth day of the STS-90 mission, the flight crew, Cmdr. Richard A. Searfoss, Pilot Scott D. Altman, and Mission Specialists Richard M. Linnehan, Dafydd Rhys Williams and Kathryn P. Hire, and Payload Specialists Jay C. Buckey and James A. Pawelczyk continue work with the Escher Staircase Behavior Testing of Adult Rats experiment. This is the first of two behavior testing sessions with the adult rats being used for this experiment. The rats will have a 'hyper drive' unit placed on their head which has recording electrodes made of microscopic wires that are positioned in the brain to record activity in the hippocampus. The hippocampus is that portion of the brain used to develop spatial maps to help us navigate from one place to the other. With the 'hyper drive' units in place, the rats will then be put through a maze or on a track. While the rat is maneuvering on the maze or track, the cell activity of the hippocampus will be measured and recorded.

  16. STS-90 Day 14 Highlights

    NASA Technical Reports Server (NTRS)

    1998-01-01

    On this fourteenth day of the STS-90 mission, the flight crew, Cmdr. Richard A. Searfoss, Pilot Scott D. Altman, and Mission Specialists Richard M. Linnehan, Dafydd Rhys Williams and Kathryn P. Hire, and Payload Specialists Jay C. Buckey and James A. Pawelczyk focus on the efforts of Neurolab's Neuronal Plasticity Team to better understand how the adult nervous system adapts to the new environment of space. Columbia's science crew -- Mission Specialists Rick Linnehan and Dave Williams and Payload Specialists Jay Buckey and Jim Pawelczyk -- perform the second and final in-flight dissections of the adult male rats on board. The crew euthanizes and dissects nine rats and remove the vestibular or balance organs of the inner ear; the cerebellum, the part of the brain critical for maintaining balance and for processing information from the limbs so they can be moved smoothly; and the cerebrum, one part of which controls automatic functions such as body temperature regulation and the body's internal clock, and the cortical region that controls cognitive functions such as thinking. The first dissection, which was performed on the second day of the flight, went extremely well, according to Neurolab scientists.

  17. Percutaneous reduction of mitral valve regurgitation using the MitraClip system - immediate and 90-day follow-up of 3 cases.

    PubMed

    Kübler, Piotr; Kustrzycka-Kratochwil, Dorota; Telichowski, Artur; Witkowski, Tomasz; Banasiak, Waldemar; Jankowska, Ewa A; Ponikowski, Piotr; Reczuch, Krzysztof

    2013-01-01

    Treatment of hemodynamically significant valvular heart diseases has been the domain of cardiac surgery for decades. However, a promising novel method is the MitraClip system, involving percutaneous connection of insufficient valve leaflets with special cobalt-chrome clips. Our study presents clinical characteristics, course of treatment with the MitraClip system, and immediate and 90-day clinical and echocardiographic follow-up of the first 3 patients treated in our institution. Subsequently, based on data from the literature and our own experience, the current position around the world, and the target group of patients who are most likely to benefit from treatment using the MitraClip system, are discussed.

  18. Safety assessment of the fermented Phylloporia ribis (Lonicera japonica Thunb.) mycelia by oral acute toxicity study in mice and 90-day feeding study in rats.

    PubMed

    Lu, Lianhua; Fan, Yiou; Yao, Wenhuan; Xie, Wei; Guo, Jie; Yan, Yan; Yang, Fei; Xu, Lingchuan

    2014-07-01

    Phylloporia ribis is an edible fungus in China. Its fermented mycelia have been approved by the National Health and Family Planning Commission (NHFPC) of PR China for use as a novel food material, but little information on its safety is available. The present research was the first to evaluate acute and subchronic toxicity in experimental animals of fermented Phylloporia ribis mycelia (FPM) following standard procedures. In acute toxicity study, FPM was orally administered to male and female mice twice a day at single dose of 10 g/kg bw. The Maximum Tolerated Dose (MTD) of FPM for mice of both sexes was over 10 g/kg bw. No death and abnormal behaviors occurred during 14 days study except for an increased locomotor activity in three animals. In 90-day feeding study, male and female Sprague-Dawley rats were fed diets containing 10.0%, 5.0%, 2.5%, 1.25% and 0% (control) FPM for 90 days. The treatment caused no effects on mortality, gross pathology, histology, hematology, and blood chemistry, no dose-dependent changes in food consumption, but caused effect on body weight gain compared with control group. The No Observed Adverse-Effect Level (NOAEL) of FPM was greater than 8.7 g/kg bw/day in both sexes of rats.

  19. Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial.

    PubMed

    Stough, Con; Downey, Luke A; Lloyd, Jenny; Silber, Beata; Redman, Stephanie; Hutchison, Chris; Wesnes, Keith; Nathan, Pradeep J

    2008-12-01

    While Ayurvedic medicine has touted the cognitive enhancing effects of Bacopa monniera for centuries, there is a need for double-blind placebo-controlled investigations. One hundred and seven healthy participants were recruited for this double-blind placebo-controlled independent group design investigation. Sixty-two participants completed the study with 80% treatment compliance. Neuropsychological testing using the Cognitive Drug Research cognitive assessment system was conducted at baseline and after 90 days of treatment with a special extract of Bacopa monniera (2 x 150 mg KeenMind) or placebo. The Bacopa monniera product significantly improved performance on the 'Working Memory' factor, more specifically spatial working memory accuracy. The number of false-positives recorded in the Rapid visual information processing task was also reduced for the Bacopa monniera group following the treatment period. The current study provides support for the two other published studies reporting cognitive enhancing effects in healthy humans after a 90 day administration of the Bacopa monniera extract. Further studies are required to ascertain the effective dosage range, the time required to attain therapeutic levels and the effects over a longer term of administration.

  20. A 90-day subchronic feeding study of genetically modified maize expressing Cry1Ac-M protein in Sprague-Dawley rats.

    PubMed

    Liu, Pengfei; He, Xiaoyun; Chen, Delong; Luo, Yunbo; Cao, Sishuo; Song, Huan; Liu, Ting; Huang, Kunlun; Xu, Wentao

    2012-09-01

    The cry1Ac-M gene, coding one of Bacillus thuringiensis (Bt) crystal proteins, was introduced into maize H99 × Hi IIB genome to produce insect-resistant GM maize BT-38. The food safety assessment of the BT-38 maize was conducted in Sprague-Dawley rats by a 90-days feeding study. We incorporated maize grains from BT-38 and H99 × Hi IIB into rodent diets at three concentrations (12.5%, 25%, 50%) and administered to Sprague-Dawley rats (n=10/sex/group) for 90 days. A commercialized rodent diet was fed to an additional group as control group. Body weight, feed consumption and toxicological response variables were measured, and gross as well as microscopic pathology were examined. Moreover, detection of residual Cry1Ac-M protein in the serum of rats fed with GM maize was conducted. No death or adverse effects were observed in the current feeding study. No adverse differences in the values of the response variables were observed between rats that consumed diets containing GM maize BT-38 and non-GM maize H99 × Hi IIB. No detectable Cry1Ac-M protein was found in the serum of rats after feeding diets containing GM maize for 3 months. The results demonstrated that BT-38 maize is as safe as conventional non-GM maize.

  1. Findings

    MedlinePlus

    ... Issue All Issues Explore Findings by Topic Cell Biology Cellular Structures, Functions, Processes, Imaging, Stress Response Chemistry ... Glycobiology, Synthesis, Natural Products, Chemical Reactions Computers in Biology Bioinformatics, Modeling, Systems Biology, Data Visualization Diseases Cancer, ...

  2. Secondary prevention lifestyle interventions initiated within 90 days after TIA or ‘minor’ stroke: a systematic review and meta-analysis of rehabilitation programmes

    PubMed Central

    Heron, Neil; Kee, Frank; Cardwell, Christopher; Tully, Mark A; Donnelly, Michael; Cupples, Margaret E

    2017-01-01

    Background Strokes are often preceded by a transient ischaemic attack (TIA) or ‘minor’ stroke. The immediate period after a TIA/minor stroke is a crucial time to initiate secondary prevention. However, the optimal approach to prevention, including non-pharmacological measures, after TIA is not clear. Aim To systematically review evidence about the effectiveness of delivering secondary prevention, with lifestyle interventions, in comprehensive rehabilitation programmes, initiated within 90 days of a TIA/minor stroke. Also, to categorise the specific behaviour change techniques used. Design and setting The review identified randomised controlled trials by searching the Cochrane Library, Ovid MEDLINE, Ovid EMBASE, Web of Science, EBSCO CINAHL and Ovid PsycINFO. Method Two review authors independently screened titles and abstracts for eligibility (programmes initiated within 90 days of event; outcomes reported for TIA/minor stroke) and extracted relevant data from appraised studies; a meta-analysis was used to synthesise the results. Results A total of 31 potentially eligible papers were identified and four studies, comprising 774 patients post-TIA or minor stroke, met the inclusion criteria; two had poor methodological quality. Individual studies reported increased aerobic capacity but meta-analysis found no significant change in resting and peak systolic blood pressure, resting heart rate, aerobic capacity, falls, or mortality. The main behaviour change techniques were goal setting and instructions about how to perform given behaviours. Conclusion There is limited evidence of the effectiveness of early post-TIA rehabilitation programmes with preventive lifestyle interventions. Further robust randomised controlled trials of comprehensive rehabilitation programmes that promote secondary prevention and lifestyle modification immediately after a TIA are needed. PMID:27919935

  3. A functional variant in the 3ˈ-UTR of VEGF predicts the 90-day outcome of ischemic stroke in Chinese patients

    PubMed Central

    Jin, Lei; Weng, Yingfeng; Wang, Yujie; Wu, Hui; Li, Xia; Huang, Ying; Wang, Shengyue

    2017-01-01

    Vascular endothelial growth factor (VEGF) plays critical roles in angiogenesis and vasculogenesis, which are associated with post-stroke functional recovery. However, the effects of the VEGFA polymorphisms on the outcome of ischemic stroke (IS) have been rarely reported. We therefore investigated the associations of +936C/T variant (rs3025039) with the susceptibilities and the 90-day outcomes from 494 IS patients and 337 healthy controls in Chinese population through the establishment of logistic multivariate regression model. Stroke severity at admission and outcome of 90 days were respectively assessed according to the National Institutes of Health Stroke Scale and the modified Rankin Scale. The analysis showed that there were no significant associations of the rs3025039 genotypes with the susceptibility (P = 0.229) and the severity (P = 0.734). However, when we divided the 308 IS patients into two groups according to the different outcomes, we found that the rs3025039 TC+TT genotype significantly increased the risk of poor recovery [adjusted odds ratio (OR), 1.99; 95% confidence interval (CI), 1.18–3.37]. Interestingly, we observed another 3ˈUTR variant, +1451C/T (rs3025040), exhibited strong linkage disequilibrium (r2 = 1.0) with +936C/T and was located in a predicted microRNA-binding site. The rs3025040 T allele significantly decreased the luciferase activities in four cell lines, which indicated a potential disruption of the miRNA-mRNA interaction that would result in lower VEGF expression levels. Our data suggested that the +936C/T variants significantly increased the risk of poorer stroke outcome by affecting the bindings of miR-199a and miR-199b to VEGF mRNA at the rs30250340 polymorphic site. PMID:28234972

  4. Petition for Reconsideration from Biogenic CO2 Coalition to Gina McCarthy, U.S. EPA, for the Finding that Greenhouse Gas Emissions from Aircraft Cause or Contribute to Air Pollution that May Reasonably be Anticipated to Endanger Public Health and Welfare

    EPA Pesticide Factsheets

    This page contains a Petition for Reconsideration From Biogenic CO2 Coalition to Gina McCarthy, U.S. EPA, for the finding that greenhouse gas emissions from aircraft cause or contribute to air pollution that may reasonably be anticipated to endanger public

  5. 77 FR 71864 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-04

    ..., Federal Aviation Administration, Transport Airplane Directorate, 1601 Lind Avenue SW., Renton, WA 98057... Federal Aviation Administration Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This...

  6. Collagen content in the vastus lateralis and the soleus muscle following a 90-day bed rest period with or without resistance exercises

    PubMed Central

    Nielsen, Rasmus Oestergaard; Schjerling, Peter; Tesch, Per; Stål, Per; Langberg, Henning

    2015-01-01

    Summary Introduction spaceflight seems associated with deterioration of the function of the skeletal muscles. Since muscle collagen is critical for muscle function, an improved understanding of the content of the muscle collagen during long-term inactivity seems important. Bed-rest with in-bed resistance training serves as a proxy for the conditions in space. Therefore, ground-based studies may improve the understanding of the consequences of long-term inactivity. Purpose the purpose is to compare the change in collagen protein in the vastus lateralis (VL) and the soleus (SOL) muscle amongst persons exposed to a 90-day bed rest with or without resistance exercise. Methods an explorative analysis was completed based on data from a randomized, controlled trial. The intervention group (BRE, SOL n=4, VL n=8) performed supine-based squat exercises, whereas the controls (BE, SOL n=6, VL n=12) remained inactive during follow-up. Muscle biopsies from vastus lateralis and soleus were taken at baseline (pre) and after 90-days’ follow-up (post). Muscle collagen (μg collagen/mg protein) was quantified. Two-way repeated measurements ANOVA was used to compare the interaction between the intervention (BRE/BR) and time (pre/post) for each muscle. Results the collagen content of VL was similar between pre and post in the BRE group (−3.8 μg collagen/mg protein [95% CI: −22.0; 14.4], p=0.68) while it rose amongst individuals in the BR group (14.9 μg collagen/mg protein [95% CI: −0.01; 29.7], p=0.05). The difference of 18.66 [95% CI: −6.5; 43.9] between BRE and BR across time was, however, not significant (p=0.14). No significant reduction in SOL muscle collagen content was observed from pre to post in the BR group (−9.3 μg collagen/mg protein [95% CI: −24.9; 6.4], p=0.25) or in the BRE group (−6.5 μg collagen/mg protein [95% CI: −25.6; 12.6], p=0.50). There was no difference in the effect of BR versus BRE over time (mean difference −2.78 μg collagen

  7. Compositional and toxicological analysis of a GM potato line with reduced α-solanine content--a 90-day feeding study in the Syrian Golden hamster.

    PubMed

    Langkilde, Søren; Schrøder, Malene; Frank, Thomas; Shepherd, Louise V T; Conner, Sean; Davies, Howard V; Meyer, Otto; Danier, Jürgen; Rychlik, Michael; Belknap, William R; McCue, Kent F; Engel, Karl-Heinz; Stewart, Derek; Knudsen, Ib; Poulsen, Morten

    2012-10-01

    Steroidal glycoalkaloids (GAs) are toxins, produced by plants of the Solanaceae family. The potato plant (Solanum tuberosum L.) and its tubers predominantly contain the two GAs α-chaconine and α-solanine. These compounds are believed to act in synergy, and the degree of toxicity may therefore depend on their ratio in the potato. To determine the influence of α-solanine: α-chaconine ratio in potatoes on toxicity, a GM potato line (SGT 9-2) with reduced α-solanine content, and the parental control line (Desirée wild-type) having a traditional α-solanine: α-chaconine ratio were (1) studied for compositional similarity by analysing for a range of potato constituents, and (2) used in a 90-day feeding trial with the Syrian Golden hamster to study differential toxicity. The animal feeding study used diets with up to 60% freeze-dried potato powder from either line. Whilst data indicated some compositional differences between the GM line and its wildtype control these did not raise concerns related to nutritional value or safety. Results of the feeding trials showed a low number of significant differences between potato lines with different α-solanine: α-chaconine ratio but none were considered to raise safety concerns with regard to human (or animal) consumption.

  8. A 90-day repeated dose oral (gavage) toxicity study of perfluorohexanoic acid (PFHxA) in rats (with functional observational battery and motor activity determinations).

    PubMed

    Chengelis, Christopher P; Kirkpatrick, Jeannie B; Radovsky, Ann; Shinohara, Motoki

    2009-06-01

    Possible toxic effects of perfluorohexanoic acid (PFHxA) were evaluated when administered orally by gavage to rats at levels up to 200mg/kg/day for 90 days. Lower body weight gains were noted in the 10, 50 and 200mg/kg/day group males (not dose-responsive) throughout dosing. Other changes included lower red blood cell parameters, higher reticulocyte counts and lower globulin in the 200mg/kg/day group males and females, higher liver enzymes in males at 50 and 200mg/kg/day, lower total protein and higher albumin/globulin ratio, and lower cholesterol, calcium in males at 200mg/kg/day. Minimal centrilobular hepatocellular hypertrophy was present in 200mg/kg/day group males and correlated with higher liver weights and slightly higher peroxisome beta oxidation activity at the end of the dosing period. Based on liver histopathology and liver weight changes, the no-observed-adverse-effect level (NOAEL) for oral administration was 50mg/kg/day for males and 200mg/kg/day for females.

  9. A 90 day safety assessment of genetically modified rice expressing Cry1Ab/1Ac protein using an aquatic animal model.

    PubMed

    Zhu, Hao-Jun; Chen, Yi; Li, Yun-He; Wang, Jia-Mei; Ding, Jia-Tong; Chen, Xiu-Ping; Peng, Yu-Fa

    2015-04-15

    In fields of transgenic Bt rice, frogs are exposed to Bt proteins through consumption of both target and nontarget insects. In the present study, we assessed the risk posed by transgenic rice expressing a Cry1Ab/1Ac fusion protein (Huahui 1, HH1) on the development of Xenopus laevis. For 90 days, froglets were fed a diet with 30% HH1 rice, 30% parental rice (Minghui 63, MH63), or no rice as a control. Body weight and length were measured every 15 days. After sacrificing the froglets, we performed a range of biological, clinical, and pathological assessments. No significant differences were found in body weight (on day 90: 27.7 ± 2.17, 27.4 ± 2.40, and 27.9 ± 1.67 g for HH1, MH63, and control, respectively), body length (on day 90: 60.2 ± 1.55, 59.3 ± 2.33, and 59.7 ± 1.64 mm for HH1, MH63, and control, respectively), animal behavior, organ weight, liver and kidney function, or the microstructure of some tissues between the froglets fed on the HH1-containing diet and those fed on the MH63-containing or control diets. This indicates that frog development was not adversely affected by dietary intake of Cry1Ab/1Ac protein.

  10. Phase II, Randomized, Placebo-controlled, 90-day Study of Emixustat HCL in Geographic Atrophy Associated with Dry Age-Related Macular Degeneration

    PubMed Central

    Dugel, Pravin U.; Novack, Roger L.; Csaky, Karl G.; Richmond, Preston P.; Birch, David G.; Kubota, Ryo

    2015-01-01

    Purpose This study assessed the safety, tolerability, and pharmacodynamics of emixustat hydrochloride (ACU-4429), a novel visual cycle modulator, in subjects with geographic atrophy (GA) associated with dry age-related macular degeneration (AMD). Methods Subjects were randomly assigned to oral emixustat (2, 5, 7, or 10 mg once daily) or placebo (3:1 ratio) for 90 days. Recovery of rod photoreceptor sensitivity following a photobleach was measured by electroretinography. Safety evaluations included analysis of adverse events (AEs) and ophthalmic examinations. Results Seventy-two subjects (54 emixustat, 18 placebo) were evaluated. Emixustat suppressed rod photoreceptor sensitivity in a dose-dependent manner. Suppression plateaued by Day 14, and was reversible within 7-14 days after drug cessation. No systemic AEs of concern were noted. Dose-related ocular AEs (chromatopsia, 57% emixustat vs. 17% placebo; and delayed dark adaptation, 48% emixustat vs. 6% placebo) were mild to moderate, and the majority resolved on study or within 7-14 days after study drug cessation. Conclusions In this phase II study, emixustat produced a dose-dependent, reversible effect on rod function, and an ocular AE profile that is consistent with the proposed mechanism of action. These results support further testing of emixustat for the treatment of GA associated with dry AMD. PMID:25932553

  11. Safety assessment of SDA soybean oil: results of a 28-day gavage study and a 90-day/one generation reproduction feeding study in rats.

    PubMed

    Hammond, Bruce G; Lemen, Joan K; Ahmed, Gulam; Miller, Kathleen D; Kirkpatrick, Jeannie; Fleeman, Tammye

    2008-12-01

    Long chain polyunsaturated fatty acids (LC-PUFAs) in the diet reduce risk of cardiac mortality. Fish oils are a dietary source of LC-PUFAs (EPA, DHA) but intake is low in Western diets. Adding beneficial amounts of LC-PUFAs to foods is limited by their instability and potential to impart off-flavors. Stearidonic acid (SDA), a precursor of EPA in man, is more stable than EPA/DHA in food matrices. SDA is present in fish oils (0.5-4%) and in nutraceuticals (echium, borage oil). Genes for Delta6, Delta15 desaturases were introduced into soybeans that convert linoleic and alpha-linolenic acid to SDA (15-30% fatty acids). Since addition of SDA soybean oil into human foods increases SDA intake, toxicology studies were undertaken to assess its safety. In a 28-day pilot study, rats were gavaged with SDA soybean oil at dosages up to 3g/kg body weight/day; no treatment-related adverse effects were observed. A 90-day/one generation rat reproduction study was subsequently conducted where SDA soybean oil was added to diets to provide daily doses of 1.5 and 4 g/kg body weight. There were no treatment-related adverse effects on parental animals or on reproductive performance and progeny development.

  12. Evaluation of 90-day Repeated Dose Oral Toxicity, Glycometabolism, Learning and Memory Ability, and Related Enzyme of Chromium Malate Supplementation in Sprague-Dawley Rats.

    PubMed

    Feng, Weiwei; Wu, Huiyu; Li, Qian; Zhou, Zhaoxiang; Chen, Yao; Zhao, Ting; Feng, Yun; Mao, Guanghua; Li, Fang; Yang, Liuqing; Wu, Xiangyang

    2015-11-01

    Our previous study showed that chromium malate improved the regulation of blood glucose in mice with alloxan-induced diabetes. The present study was designed to evaluate the 90-day oral toxicity of chromium malate in Sprague-Dawley rats. The present study inspected the effect of chromium malate on glycometabolism, glycometabolism-related enzymes, lipid metabolism, and learning and memory ability in metabolically healthy Sprague-Dawley rats. The results showed that all rats survived and pathological, toxic, feces, and urine changes were not observed. Chromium malate did not cause measurable damage on liver, brain, and kidney. The fasting blood glucose, serum insulin, insulin resistance index, C-peptide, hepatic glycogen, glucose-6-phosphate dehydrogenase, glucokinase, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglyceride levels of normal rats in chromium malate groups had no significant change when compared with control group and chromium picolinate group under physiologically relevant conditions. The serum and organ content of Cr in chromium malate groups had no significant change compared with control group. No significant changes were found in morris water maze test and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and true choline esterase (TChE) activity. The results indicated that supplementation with chromium malate did not cause measurable toxicity and has no obvious effect on glycometabolism and related enzymes, learning and memory ability, and related enzymes and lipid metabolism of female and male rats. The results of this study suggest that chromium malate is safe for human consumption.

  13. Metabonomics study of transgenic Bacillus thuringiensis rice (T2A-1) meal in a 90-day dietary toxicity study in rats.

    PubMed

    Cao, Sishuo; Xu, Wentao; Luo, YunBo; He, Xiaoyun; Yuan, Yanfang; Ran, Wenjun; Liang, Lixing; Huang, Kunlun

    2011-07-01

    Rice is one of the most important staple foods in the world. The Cry2A gene was inserted into the rice genome to help the plant combat insects. As the unintended effects of the genetically modified (GM) organisms are the most important barriers to the promotion of GM organisms, we have carried out a useful exploration to establish a new in vivo evaluation model for genetically modified foods by metabonomics methods. In this study, the rats were fed for 90 days with the GM and NON-GM rice diets. The changes in metabolites of the urine were detected using (1)H-NMR. The metabonomics were analyzed to see whether the GM rice can induce the metabolite changes in the rats' urine when compared with the NON-GM rice group. The multivariate analysis and ANOVA were used to determine the differences and the significance of differences respectively, and eventually we concluded that these differences did not have a biological significance. The conclusion of the metabonomics was comparable with that from the traditional method. As a non-invasive and dynamic monitoring method, metabonomics will be a new way of assessing the food safety of GM foods.

  14. Assessment of the reporting of quality and outcome measures in hepatic resections: a call for 90-day reporting in all hepatectomy series

    PubMed Central

    Egger, Michael E; Ohlendorf, Joanna M; Scoggins, Charles R; McMasters, Kelly M; Martin, Robert C G

    2015-01-01

    Background The aim of this paper is to assess the current state of quality and outcomes measures being reported for hepatic resections in the recent literature. Methods Medline and PubMed databases were searched for English language articles published between 1 January 2002 and 30 April 2013. Two examiners reviewed each article and relevant citations for appropriateness of inclusion, which excluded papers of liver donor hepatic resections, repeat hepatectomies or meta-analyses. Data were extracted and summarized by two examiners for analysis. Results Fifty-five studies were identified with suitable reporting to assess peri-operative mortality in hepatic resections. In only 35% (19/55) of the studies was the follow-up time explicitly stated, and in 47% (26/55) of studies peri-operative mortality was limited to in-hospital or 30 days. The time period in which complications were captured was not explicitly stated in 19 out of 28 studies. The remaining studies only captured complications within 30 days of the index operation (8/28). There was a paucity of quality literature addressing truly patient-centred outcomes. Conclusion Quality outcomes after a hepatic resection are inconsistently reported in the literature. Quality outcome studies for a hepatectomy should report mortality and morbidity at a minimum of 90 days after surgery. PMID:26228262

  15. Evaluation of the Tobacco Heating System 2.2. Part 4: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects compared with cigarette smoke.

    PubMed

    Wong, Ee Tsin; Kogel, Ulrike; Veljkovic, Emilija; Martin, Florian; Xiang, Yang; Boue, Stephanie; Vuillaume, Gregory; Leroy, Patrice; Guedj, Emmanuel; Rodrigo, Gregory; Ivanov, Nikolai V; Hoeng, Julia; Peitsch, Manuel C; Vanscheeuwijck, Patrick

    2016-11-30

    The objective of the study was to characterize the toxicity from sub-chronic inhalation of test atmospheres from the candidate modified risk tobacco product (MRTP), Tobacco Heating System version 2.2 (THS2.2), and to compare it with that of the 3R4F reference cigarette. A 90-day nose-only inhalation study on Sprague-Dawley rats was performed, combining classical and systems toxicology approaches. Reduction in respiratory minute volume, degree of lung inflammation, and histopathological findings in the respiratory tract organs were significantly less pronounced in THS2.2-exposed groups compared with 3R4F-exposed groups. Transcriptomics data obtained from nasal epithelium and lung parenchyma showed concentration-dependent differential gene expression following 3R4F exposure that was less pronounced in the THS2.2-exposed groups. Molecular network analysis showed that inflammatory processes were the most affected by 3R4F, while the extent of THS2.2 impact was much lower. Most other toxicological endpoints evaluated did not show exposure-related effects. Where findings were observed, the effects were similar in 3R4F- and THS2.2-exposed animals. In summary, toxicological changes observed in the respiratory tract organs of THS2.2 aerosol-exposed rats were much less pronounced than in 3R4F-exposed rats while other toxicological endpoints either showed no exposure-related effects or were comparable to what was observed in the 3R4F-exposed rats.

  16. 76 FR 61474 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-04

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2011-43 Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of petition for...

  17. 29 CFR 2570.154 - Filing and contents of petition.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Under ERISA Sec. 3(40) § 2570.154 Filing and contents of petition. (a) A person seeking a finding under section 3(40) of ERISA must file a written petition by delivering or mailing it to the Chief Docket Clerk... is an employee welfare benefit plan as defined at section 3(1) of ERISA (29 U.S.C. 1002(1)) and...

  18. 29 CFR 2570.154 - Filing and contents of petition.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Under ERISA Sec. 3(40) § 2570.154 Filing and contents of petition. (a) A person seeking a finding under section 3(40) of ERISA must file a written petition by delivering or mailing it to the Chief Docket Clerk... is an employee welfare benefit plan as defined at section 3(1) of ERISA (29 U.S.C. 1002(1)) and...

  19. 29 CFR 2570.154 - Filing and contents of petition.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Under ERISA Sec. 3(40) § 2570.154 Filing and contents of petition. (a) A person seeking a finding under section 3(40) of ERISA must file a written petition by delivering or mailing it to the Chief Docket Clerk... is an employee welfare benefit plan as defined at section 3(1) of ERISA (29 U.S.C. 1002(1)) and...

  20. 29 CFR 2570.154 - Filing and contents of petition.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Under ERISA Sec. 3(40) § 2570.154 Filing and contents of petition. (a) A person seeking a finding under section 3(40) of ERISA must file a written petition by delivering or mailing it to the Chief Docket Clerk... is an employee welfare benefit plan as defined at section 3(1) of ERISA (29 U.S.C. 1002(1)) and...

  1. 29 CFR 2570.154 - Filing and contents of petition.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Under ERISA Sec. 3(40) § 2570.154 Filing and contents of petition. (a) A person seeking a finding under section 3(40) of ERISA must file a written petition by delivering or mailing it to the Chief Docket Clerk... is an employee welfare benefit plan as defined at section 3(1) of ERISA (29 U.S.C. 1002(1)) and...

  2. Physico-chemical properties of a novel (-)-hydroxycitric acid extract and its effect on body weight, selected organ weights, hepatic lipid peroxidation and DNA fragmentation, hematology and clinical chemistry, and histopathological changes over a period of 90 days.

    PubMed

    Shara, Michael; Ohia, Sunny E; Schmidt, Robert E; Yasmin, Taharat; Zardetto-Smith, Andrea; Kincaid, Anthony; Bagchi, Manashi; Chatterjee, Archana; Bagchi, Debasis; Stohs, Sidney J

    2004-05-01

    Garcinia cambogia-derived (-)-hydroxycitric acid (HCA) is a popular and natural supplement for weight management. HCA is a competitive inhibitor of the enzyme ATP citrate lyase, which catalyzes the conversion of citrate and coenzyme A to oxaloacetate and acetyl coenzyme A (acetyl CoA) in the cytosol. Acetyl CoA is used in the synthesis of fatty acids, cholesterol and triglycerides, and in the synthesis of acetylcholine in the central nervous system. Studies have demonstrated the efficacy of a novel 60% calcium-potassium salt of HCA derived from Garcinia cambogia (HCA-SX, Super CitriMax) in weight management. Results have shown that HCA-SX promotes fat oxidation, enhances serotonin release and availability in the brain cortex, normalizes lipid profiles, and lowers serum leptin levels in obese subjects. Acute oral, acute dermal, primary dermal irritation and primary eye irritation toxicity, as well as Ames bacterial reverse mutation studies and mouse lymphoma tests have demonstrated the safety of HCA-SX. However, no detailed long-term safety of HCA-SX or any other HCA extract has been previously assessed. We evaluated the dose- and time-dependent effects of HCA-SX in Sprague-Dawley rats on body weight, selected organ weights, hepatic lipid peroxidation and DNA fragmentation, hematology and clinical chemistry over a period of 90 days. Furthermore, a 90-day histopathological evaluation was conducted. The animals were treated with 0, 0.2, 2.0 and 5.0% HCA-SX of feed intake and were sacrificed on 30, 60 or 90 days of treatment. The body weight and selected organ weights were assessed and correlated as a % of body weight and brain weight at 90 days of treatment. A significant reduction in body weight was observed in treated rats as compared to control animals. An advancing age-induced marginal increase in hepatic lipid peroxidation was observed in both male and female rats, while no such difference in hepatic DNA fragmentation was observed as compared to the control

  3. North Shore Apartments Petition

    EPA Pesticide Factsheets

    This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  4. Dose- and time-dependent effects of a novel (-)-hydroxycitric acid extract on body weight, hepatic and testicular lipid peroxidation, DNA fragmentation and histopathological data over a period of 90 days.

    PubMed

    Shara, Michael; Ohia, Sunny E; Yasmin, Taharat; Zardetto-Smith, Andrea; Kincaid, Anthony; Bagchi, Manashi; Chatterjee, Archana; Bagchi, Debasis; Stohs, Sidney J

    2003-12-01

    (-)-Hydroxycitric acid (HCA), a natural extract from the dried fruit rind of Garcinia cambogia (family Guttiferae), is a popular supplement for weight management. The dried fruit rind has been used for centuries as a condiment in Southeastern Asia to make food more filling and satisfying. A significant number of studies highlight the efficacy of Super CitriMax (HCA-SX, a novel 60% calcium-potassium salt of HCA derived from Garcinia cambogia) in weight management. These studies also demonstrate that HCA-SX promotes fat oxidation, inhibits ATP-citrate lyase (a building block for fat synthesis), and lowers the level of leptin in obese subjects. Acute oral, acute dermal, primary dermal irritation and primary eye irritation toxicity studies have demonstrated the safety of HCA-SX. However, no long-term safety of HCA-SX or any other (-)-hydroxycitric acid extract has been previously assessed. In this study, we have evaluated the dose- and time-dependent effects of HCA-SX in Sprague-Dawley rats on body weight, hepatic and testicular lipid peroxidation, DNA fragmentation, liver and testis weight, expressed as such and as a % of body weight and brain weight, and histopathological changes over a period of 90 days. The animals were treated with 0, 0.2, 2.0 and 5.0% HCA-SX as feed intake and the animals were sacrificed on 30, 60 or 90 days of treatment. The feed and water intake were assessed and correlated with the reduction in body weight. HCA-SX supplementation demonstrated a reduction in body weight in both male and female rats over a period of 90 days as compared to the corresponding control animals. An advancing age-induced marginal increase in hepatic lipid peroxidation was observed in both male and female rats as compared to the corresponding control animals. However, no such difference in hepatic DNA fragmentation and testicular lipid peroxidation and DNA fragmentation was observed. Furthermore, liver and testis weight, expressed as such and as a percentage of body

  5. 77 FR 61469 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-09

    ... of Rulemaking. Petition for Exemption Docket No.: FAA-2012-0113. Petitioner: Southwest Airlines... allow Southwest to operate its aircraft without carrying the appropriate parts of the maintenance...

  6. Peste des petits ruminants in Arabian wildlife.

    PubMed

    Kinne, J; Kreutzer, R; Kreutzer, M; Wernery, U; Wohlsein, P

    2010-08-01

    Recurrence of peste des petits ruminants (PPR) was diagnosed in the United Arabian Emirates in several wild ruminants confirmed by morphological, immunohistochemical, serological and molecular findings. Phylogenetic analysis revealed that the virus strain belongs to lineage IV, which is different to some previously isolated PPR strains from the Arabian Peninsula. This study shows that wild ruminants may play an important epidemiological role as virus source for domestic small ruminants.

  7. Assessment of the safety of hydrogenated resistant maltodextrin: reverse mutation assay, acute and 90-day subchronic repeated oral toxicity in rats, and acute no-effect level for diarrhea in humans.

    PubMed

    Yoshikawa, Yuko; Kishimoto, Yuka; Tagami, Hiroyuki; Kanahori, Sumiko

    2013-01-01

    A series of safety assessments were performed on hydrogenated resistant maltodextrin prepared by converting the reducing terminal glucose of resistant maltodextrin into sorbitol. The reverse mutation assay did not show mutagenicity. Acute and 90-day subchronic oral toxicity studies in rats showed no death was observed in any groups, including the group receiving the highest single dose of 10 g/kg body weight or the highest dose of 5 g/kg body weight per day for 90 days. Mucous or watery stools were observed in the hydrogenated resistant maltodextrin treatment group on the acute study, which were transient and were associated with the osmotic pressure caused by intake of the high concentrations. Subchronic study showed dose-dependent increases in the weights of cecum alone, cecal contents alone, and cecum with cecal contents as well as hypertrophy of the cecal mucosal epithelium, which are considered to be common physiological responses after intake of indigestible carbohydrates. These results indicated that the no observed adverse effect level (NOAEL) of hydrogenated resistant maltodextrin was 10 g/kg body weight or more on the acute oral toxicity study and 5.0 g/kg body weight/day or more on the 90-day subchronic repeated oral toxicity study in rats. Further study performed in healthy adult humans showed that the acute no-effect level of hydrogenated resistant maltodextrin for diarrhea was 0.8 g/kg body weight for men and more than 1.0 g/kg body weight for women. The results of the current safety assessment studies suggest that hydrogenated resistant maltodextrin is safe for human consumption.

  8. 78 FR 43093 - Richard C. Theuer; Filing of Food Additive Petition and Citizen Petition

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-19

    ... Additive Petition and Citizen Petition AGENCY: Food and Drug Administration, HHS. ACTION: Notice of...., has filed a petition proposing that the food additive regulations be amended to prohibit the use of... a food additive petition (FAP 3A4798; Docket No. FDA-2013-F-0700). The petition proposes to...

  9. 75 FR 26843 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-12

    ... [Federal Register Volume 75, Number 91 (Wednesday, May 12, 2010)] [Notices] [Pages 26843-26844] [FR Doc No: 2010-11256] DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2010-24] Petition for Exemption; Summary of Petition Received AGENCY: Federal...

  10. 77 FR 31063 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ... [Federal Register Volume 77, Number 101 (Thursday, May 24, 2012)] [Notices] [Pages 31063-31064] [FR Doc No: 2012-12667] DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2012-22] Petition for Exemption; Summary of Petition Received AGENCY: Federal...

  11. 75 FR 26839 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-12

    ... [Federal Register Volume 75, Number 91 (Wednesday, May 12, 2010)] [Notices] [Pages 26839-26840] [FR Doc No: 2010-11289] DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2010-21] Petition for Exemption; Summary of Petition Received AGENCY: Federal...

  12. 76 FR 6180 - Petitions for Exemption; Summary of Petitions Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-03

    ... [Federal Register Volume 76, Number 23 (Thursday, February 3, 2011)] [Notices] [Pages 6180-6181] [FR Doc No: 2011-2296] DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2011-04] Petitions for Exemption; Summary of Petitions Received AGENCY: Federal...

  13. Comparison of growth, serum biochemistries and n-6 fatty acid metabolism in rats fed diets supplemented with high-gamma-linolenic acid safflower oil or borage oil for 90 days.

    PubMed

    Tso, Patrick; Caldwell, Jody; Lee, Dana; Boivin, Gregory P; DeMichele, Stephen J

    2012-06-01

    Recently, steps have been taken to further developments toward increasing gamma-linolenic acid (GLA) concentration and lowering costs in plant seed oils using transgenic technology. Through identification and expression of a fungal delta-6 desaturase gene in the high linoleic acid safflower plant, the seeds from this genetic transformation produce oil with >40% GLA (high GLA safflower oil (HGSO)). The aim of the study was to compare the effects of feeding HGSO to a generally recognized as safe source of GLA, borage oil, in a 90 day safety study in rats. Weanling male and female Sprague-Dawley rats were fed a semi-synthetic, fat free, pelleted diet (AIN93G) supplemented with a 10% (wt/wt) oil blend containing HGSO or borage oil, with equivalent GLA levels. Results demonstrated that feeding diets containing HGSO or borage oil for 90 days had similar biologic effects with regard to growth characteristics, body composition, behavior, organ weight and histology, and parameters of hematology and serum biochemistries in both sexes. Metabolism of the primary n-6 fatty acids in plasma and organ phospholipids was similar, despite minor changes in females. We conclude that HGSO is biologically equivalent to borage oil and provides a safe alternative source of GLA in the diet.

  14. 16 CFR 1051.10 - Granting petitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Granting petitions. 1051.10 Section 1051.10... § 1051.10 Granting petitions. (a) The Commission shall either grant or deny a petition within a.... The Commission may also grant a petition in part or deny it in part. If the Commission grants...

  15. 36 CFR 294.14 - Petition contents.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Petition contents. 294.14 Section 294.14 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SPECIAL AREAS State Petitions for Inventoried Roadless Area Management § 294.14 Petition contents. (a) Any petition made pursuant to § 294.12 shall provide...

  16. 36 CFR 294.14 - Petition contents.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Petition contents. 294.14 Section 294.14 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SPECIAL AREAS State Petitions for Inventoried Roadless Area Management § 294.14 Petition contents. (a) Any petition made pursuant to § 294.12 shall provide...

  17. 36 CFR 294.14 - Petition contents.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 2 2012-07-01 2012-07-01 false Petition contents. 294.14 Section 294.14 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SPECIAL AREAS State Petitions for Inventoried Roadless Area Management § 294.14 Petition contents. (a) Any petition made pursuant to § 294.12 shall provide...

  18. 36 CFR 294.14 - Petition contents.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 2 2014-07-01 2014-07-01 false Petition contents. 294.14 Section 294.14 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SPECIAL AREAS State Petitions for Inventoried Roadless Area Management § 294.14 Petition contents. (a) Any petition made pursuant to § 294.12 shall provide...

  19. 36 CFR 294.14 - Petition contents.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 2 2013-07-01 2013-07-01 false Petition contents. 294.14 Section 294.14 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SPECIAL AREAS State Petitions for Inventoried Roadless Area Management § 294.14 Petition contents. (a) Any petition made pursuant to § 294.12 shall provide...

  20. 16 CFR 1051.10 - Granting petitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Granting petitions. 1051.10 Section 1051.10... § 1051.10 Granting petitions. (a) The Commission shall either grant or deny a petition within a.... The Commission may also grant a petition in part or deny it in part. If the Commission grants...

  1. 10 CFR 501.3 - Petitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Petitions. 501.3 Section 501.3 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS ADMINISTRATIVE PROCEDURES AND SANCTIONS General Provisions § 501.3 Petitions. (a) Filing of petitions. Petitions for exemptions are to be filed with OFE at the address given in §...

  2. Using Petitions To Teach Slavery.

    ERIC Educational Resources Information Center

    Freeman, Damon

    2003-01-01

    Presents a lesson for teaching students about slavery in the United States by using slavery petitions. Describes a lesson that spans over two class periods, explaining that on the first day students listen to an interview with Professor Loren Schweninger about the "Talking History" program. Includes reproductions of the petitions. (CMK)

  3. Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90 days of exposure to hexavalent chromium in drinking water

    SciTech Connect

    Kopec, Anna K.; Kim, Suntae; Forgacs, Agnes L.; Zacharewski, Timothy R.; Proctor, Deborah M.; Harris, Mark A.; Haws, Laurie C.; Thompson, Chad M.

    2012-02-15

    Chronic administration of high doses of hexavalent chromium [Cr(VI)] as sodium dichromate dihydrate (SDD) elicits alimentary cancers in mice. To further elucidate key events underlying tumor formation, a 90-day drinking water study was conducted in B6C3F1 mice. Differential gene expression was examined in duodenal and jejunal epithelial samples following 7 or 90 days of exposure to 0, 0.3, 4, 14, 60, 170 or 520 mg/L SDD in drinking water. Genome-wide microarray analyses identified 6562 duodenal and 4448 jejunal unique differentially expressed genes at day 8, and 4630 and 4845 unique changes, respectively, in the duodenum and jejunum at day 91. Comparative analysis identified significant overlap in duodenal and jejunal differential gene expression. Automated dose–response modeling identified > 80% of the differentially expressed genes exhibited sigmoidal dose–response curves with EC{sub 50} values ranging from 10 to 100 mg/L SDD. Only 16 genes satisfying the dose-dependent differential expression criteria had EC{sub 50} values < 10 mg/L SDD, 3 of which were regulated by Nrf2, suggesting oxidative stress in response to SDD at low concentrations. Analyses of differentially expressed genes identified over-represented functions associated with oxidative stress, cell cycle, lipid metabolism, and immune responses consistent with the reported effects on redox status and histopathology at corresponding SDD drinking water concentrations. Collectively, these data are consistent with a mode of action involving oxidative stress and cytotoxicity as early key events. This suggests that the tumorigenic effects of chronic Cr(VI) oral exposure likely require chronic tissue damage and compensatory epithelial cell proliferation. Highlights: ► Mouse small intestine gene expression is highly responsive to hexavalent chromium [Cr(VI)]. ► Cr(VI) elicits more differential gene expression after 7 days of exposure than 90 days of exposure. ► Oral exposure to Cr(VI) leads to

  4. Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90days of exposure to hexavalent chromium in drinking water.

    PubMed

    Kopec, Anna K; Kim, Suntae; Forgacs, Agnes L; Zacharewski, Timothy R; Proctor, Deborah M; Harris, Mark A; Haws, Laurie C; Thompson, Chad M

    2012-02-15

    Chronic administration of high doses of hexavalent chromium [Cr(VI)] as sodium dichromate dihydrate (SDD) elicits alimentary cancers in mice. To further elucidate key events underlying tumor formation, a 90-day drinking water study was conducted in B6C3F1 mice. Differential gene expression was examined in duodenal and jejunal epithelial samples following 7 or 90days of exposure to 0, 0.3, 4, 14, 60, 170 or 520mg/L SDD in drinking water. Genome-wide microarray analyses identified 6562 duodenal and 4448 jejunal unique differentially expressed genes at day 8, and 4630 and 4845 unique changes, respectively, in the duodenum and jejunum at day 91. Comparative analysis identified significant overlap in duodenal and jejunal differential gene expression. Automated dose-response modeling identified >80% of the differentially expressed genes exhibited sigmoidal dose-response curves with EC(50) values ranging from 10 to 100mg/L SDD. Only 16 genes satisfying the dose-dependent differential expression criteria had EC(50) values <10mg/L SDD, 3 of which were regulated by Nrf2, suggesting oxidative stress in response to SDD at low concentrations. Analyses of differentially expressed genes identified over-represented functions associated with oxidative stress, cell cycle, lipid metabolism, and immune responses consistent with the reported effects on redox status and histopathology at corresponding SDD drinking water concentrations. Collectively, these data are consistent with a mode of action involving oxidative stress and cytotoxicity as early key events. This suggests that the tumorigenic effects of chronic Cr(VI) oral exposure likely require chronic tissue damage and compensatory epithelial cell proliferation.

  5. 75 FR 65396 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-22

    ... November 1, 2010. ADDRESSES: You may send comments identified by Docket Number FAA-2010- 1057 using any of... Hamilton-Powell, Director, Office of Rulemaking. Petition for Exemption Docket No.:...

  6. 77 FR 44309 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-27

    ....gov , including any personal information you provide. Using the search function of our docket Web site... Rulemaking. Petition for Exemption Docket No.: FAA-2012-0081. Petitioner: Blue Ridge Community...

  7. 77 FR 65763 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-30

    .... ADDRESSES: You may send comments identified by Docket Number FAA-2009- 1077 using any of the following..., Office of Rulemaking. Petition for Exemption Docket No.: FAA-2009-1077. Petitioner: Learjet Inc....

  8. 75 FR 10016 - Petition for Exemption; Summary of Petitions Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    ... Aviation Administration (FAA), DOT. ACTION: Notice of petition for exemption received. SUMMARY: This notice... physiology. Life support equipment capabilities vs. aircraft operating altitude performance capability. Crew emergency training and passenger protection. Potential failure modes that would require the use of...

  9. 75 FR 3278 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-20

    ..., 2010. ADDRESSES: You may send comments identified by Docket Number FAA-2009- 1058 using any of the.... Pamela Hamilton-Powell, Director, Office of Rulemaking. Petition for Exemption Docket No.:...

  10. 76 FR 39976 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    .... Petition for Exemption Docket No.: FAA-2011-0457. Petitioner: Gama Charters, Inc. Section of 14 CFR Affected: 14 CFR 135.151(h). Description of Relief Sought: Gama Charters, Inc. requests relief to...

  11. 75 FR 57328 - Petitions for Exemption; Summary of Petitions Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-20

    ... of this notice is to improve the public's awareness of, and participation in, this aspect of FAA's..., Office of Rulemaking. Petitions for Exemption Docket No.: FAA-2010-0287. Petitioner: Bombardier...

  12. 76 FR 9852 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-22

    ... activities. Neither publication of this notice nor the inclusion or omission of information in the summary is..., Office of Rulemaking. Petition for Exemption Docket No.: FAA-2010-1244. Petitioner: Emivest...

  13. 76 FR 72494 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-23

    .... ADDRESSES: You may send comments identified by Docket Number FAA-2011- 1042 using any of the following..., Director, Office of Rulemaking. Petition for Exemption Docket No.: FAA-2011-1042. Petitioner: The...

  14. 76 FR 81010 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-27

    ... 17, 2012. ADDRESSES: You may send comments identified by Docket Number FAA-2011- 1044 using any of..., Office of Rulemaking. Petition For Exemption Docket No.: FAA-2011-1044. Petitioner: Sundance...

  15. 75 FR 10016 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    .... ADDRESSES: You may send comments identified by Docket Number FAA-2009- 1087 using any of the following... Rulemaking. Petition for Exemption Docket No.: FAA-2009-1087. Petitioner: Terrafugia, Inc. Section of 14...

  16. 77 FR 36333 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-18

    ..., Acting Director, Office of Rulemaking. Petition for Exemption Docket No.: FAA-2012-0587 Petitioner: Fern... relief sought would allow Ms. Fern Case to use the aircraft lavatory while the Fasten Seat Belt sign...

  17. 28 CFR 1.1 - Submission of petition; form to be used; contents of petition.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Submission of petition; form to be used; contents of petition. 1.1 Section 1.1 Judicial Administration DEPARTMENT OF JUSTICE EXECUTIVE CLEMENCY § 1.1 Submission of petition; form to be used; contents of petition. A person seeking executive...

  18. 28 CFR 1.1 - Submission of petition; form to be used; contents of petition.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Submission of petition; form to be used; contents of petition. 1.1 Section 1.1 Judicial Administration DEPARTMENT OF JUSTICE EXECUTIVE CLEMENCY § 1.1 Submission of petition; form to be used; contents of petition. A person seeking executive...

  19. 75 FR 41530 - Petitions for Modification; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-16

    ... Safety and Health Administration Petitions for Modification; Correction AGENCY: Mine Safety and Health Administration, Labor. ACTION: Notice; correction. SUMMARY: The Mine Safety and Health Administration (MSHA... existing safety standards. The document contains an ] under II. Petitions for Modification,...

  20. 40 CFR 1700.12 - Petition requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... NATIONAL DISCHARGE STANDARDS FOR VESSELS OF THE ARMED FORCES UNIFORM NATIONAL DISCHARGE STANDARDS FOR VESSELS OF THE ARMED FORCES Effect on States State Petition for Review § 1700.12 Petition requirements....

  1. 40 CFR 1700.13 - Petition decisions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... NATIONAL DISCHARGE STANDARDS FOR VESSELS OF THE ARMED FORCES UNIFORM NATIONAL DISCHARGE STANDARDS FOR VESSELS OF THE ARMED FORCES Effect on States State Petition for Review § 1700.13 Petition decisions....

  2. 40 CFR 1700.12 - Petition requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... NATIONAL DISCHARGE STANDARDS FOR VESSELS OF THE ARMED FORCES UNIFORM NATIONAL DISCHARGE STANDARDS FOR VESSELS OF THE ARMED FORCES Effect on States State Petition for Review § 1700.12 Petition requirements....

  3. 40 CFR 1700.13 - Petition decisions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... NATIONAL DISCHARGE STANDARDS FOR VESSELS OF THE ARMED FORCES UNIFORM NATIONAL DISCHARGE STANDARDS FOR VESSELS OF THE ARMED FORCES Effect on States State Petition for Review § 1700.13 Petition decisions....

  4. 40 CFR 1700.12 - Petition requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... NATIONAL DISCHARGE STANDARDS FOR VESSELS OF THE ARMED FORCES UNIFORM NATIONAL DISCHARGE STANDARDS FOR VESSELS OF THE ARMED FORCES Effect on States State Petition for Review § 1700.12 Petition requirements....

  5. 40 CFR 1700.12 - Petition requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... NATIONAL DISCHARGE STANDARDS FOR VESSELS OF THE ARMED FORCES UNIFORM NATIONAL DISCHARGE STANDARDS FOR VESSELS OF THE ARMED FORCES Effect on States State Petition for Review § 1700.12 Petition requirements....

  6. 40 CFR 1700.13 - Petition decisions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... NATIONAL DISCHARGE STANDARDS FOR VESSELS OF THE ARMED FORCES UNIFORM NATIONAL DISCHARGE STANDARDS FOR VESSELS OF THE ARMED FORCES Effect on States State Petition for Review § 1700.13 Petition decisions....

  7. 40 CFR 1700.13 - Petition decisions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... NATIONAL DISCHARGE STANDARDS FOR VESSELS OF THE ARMED FORCES UNIFORM NATIONAL DISCHARGE STANDARDS FOR VESSELS OF THE ARMED FORCES Effect on States State Petition for Review § 1700.13 Petition decisions....

  8. 40 CFR 1700.13 - Petition decisions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... NATIONAL DISCHARGE STANDARDS FOR VESSELS OF THE ARMED FORCES UNIFORM NATIONAL DISCHARGE STANDARDS FOR VESSELS OF THE ARMED FORCES Effect on States State Petition for Review § 1700.13 Petition decisions....

  9. Evaluation of the Tobacco Heating System 2.2. Part 6: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of a mentholated version compared with mentholated and non-mentholated cigarette smoke.

    PubMed

    Oviedo, Alberto; Lebrun, Stefan; Kogel, Ulrike; Ho, Jenny; Tan, Wei Teck; Titz, Bjoern; Leroy, Patrice; Vuillaume, Gregory; Bera, Monali; Martin, Florian; Rodrigo, Gregory; Esposito, Marco; Dempsey, Ruth; Ivanov, Nikolai V; Hoeng, Julia; Peitsch, Manuel C; Vanscheeuwijck, Patrick

    2016-11-30

    The toxicity of a mentholated version of the Tobacco Heating System (THS2.2M), a candidate modified risk tobacco product (MRTP), was characterized in a 90-day OECD inhalation study. Differential gene and protein expression analysis of nasal epithelium and lung tissue was also performed to record exposure effects at the molecular level. Rats were exposed to filtered air (sham), to THS2.2M (at 15, 23 and 50 μg nicotine/l), to two mentholated reference cigarettes (MRC) (at 23 μg nicotine/l), or to the 3R4F reference cigarette (at 23 μg nicotine/l). MRCs were designed to meet 3R4F specifications. Test atmosphere analyses demonstrated that aldehydes were reduced by 75%-90% and carbon monoxide by 98% in THS2.2M aerosol compared with MRC smoke; aerosol uptake was confirmed by carboxyhemoglobin and menthol concentrations in blood, and by the quantities of urinary nicotine metabolites. Systemic toxicity and alterations in the respiratory tract were significantly lower in THS2.2M-exposed rats compared with MRC and 3R4F. Pulmonary inflammation and the magnitude of the changes in gene and protein expression were also dramatically lower after THS2.2M exposure compared with MRCs and 3R4F. No menthol-related effects were observed after MRC mainstream smoke-exposure compared with 3R4F.

  10. 7 CFR 1.28 - Petitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Petitions. 1.28 Section 1.28 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Departmental Proceedings § 1.28 Petitions. Petitions by interested persons in accordance with 5 U.S.C. 553(e) for the issuance, amendment or repeal of a rule may...

  11. 7 CFR 1.28 - Petitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Petitions. 1.28 Section 1.28 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Departmental Proceedings § 1.28 Petitions. Petitions by interested persons in accordance with 5 U.S.C. 553(e) for the issuance, amendment or repeal of a rule may...

  12. 16 CFR 1702.18 - Denying petitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Denying petitions. 1702.18 Section 1702.18 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION PROCEDURES...

  13. 16 CFR 1702.17 - Granting petitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Granting petitions. 1702.17 Section 1702.17 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION PROCEDURES...

  14. 16 CFR 1702.18 - Denying petitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Denying petitions. 1702.18 Section 1702.18 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION PROCEDURES...

  15. 16 CFR 1702.18 - Denying petitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Denying petitions. 1702.18 Section 1702.18 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION PROCEDURES...

  16. 16 CFR 1702.17 - Granting petitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Granting petitions. 1702.17 Section 1702.17 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION PROCEDURES...

  17. 16 CFR 1702.18 - Denying petitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Denying petitions. 1702.18 Section 1702.18 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION PROCEDURES...

  18. 16 CFR 1702.17 - Granting petitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Granting petitions. 1702.17 Section 1702.17 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION PROCEDURES...

  19. 16 CFR 1702.18 - Denying petitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Denying petitions. 1702.18 Section 1702.18 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION PROCEDURES...

  20. 16 CFR 1702.17 - Granting petitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Granting petitions. 1702.17 Section 1702.17 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION PROCEDURES...

  1. 16 CFR 1702.17 - Granting petitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Granting petitions. 1702.17 Section 1702.17 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION PROCEDURES...

  2. 37 CFR 41.3 - Petitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Board may authorize in writing, a party may: (i) File the petition within 14 days from the date of the... petition decision within 14 days of the decision on petition or such other time as the Board may set. (2) A... an amendment published at 73 FR 32973, June 10, 2008. Per final rule published at 73 FR...

  3. 49 CFR 1155.10 - Contents of petition.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Petitions To Require a Facility in Existence on October 16, 2008, To Apply for a Land-Use-Exemption Permit § 1155.10 Contents of petition. A petition to require a solid waste rail transfer facility in...

  4. 30 CFR 1229.101 - Petition for delegation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... management-related activities on their lands, may petition the Secretary to assume responsibilities to... approve or disapprove the petition. (d) In the event that the Secretary denies the petition, the...

  5. Chaffee Landfill... NYPIRG Petition Response

    EPA Pesticide Factsheets

    This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  6. 78 FR 49749 - Williams Olefins Feedstock Pipelines, L.L.C.; Notice of Petition for Declaratory Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-15

    ... petition requesting a declaratory order finding that a proposed Bayou Ethane Pipeline project is not subject to Commission's jurisdiction because the transported ethane will only be used as feedstock...

  7. Peste des petits ruminants

    PubMed Central

    Parida, S.; Muniraju, M.; Mahapatra, M.; Muthuchelvan, D.; Buczkowski, H.; Banyard, A.C.

    2015-01-01

    Peste des petits ruminants virus causes a highly infectious disease of small ruminants that is endemic across Africa, the Middle East and large regions of Asia. The virus is considered to be a major obstacle to the development of sustainable agriculture across the developing world and has recently been targeted by the World Organisation for Animal Health (OIE) and the Food and Agriculture Organisation (FAO) for eradication with the aim of global elimination of the disease by 2030. Fundamentally, the vaccines required to successfully achieve this goal are currently available, but the availability of novel vaccine preparations to also fulfill the requisite for differentiation between infected and vaccinated animals (DIVA) may reduce the time taken and the financial costs of serological surveillance in the later stages of any eradication campaign. Here, we overview what is currently known about the virus, with reference to its origin, updated global circulation, molecular evolution, diagnostic tools and vaccines currently available to combat the disease. Further, we comment on recent developments in our knowledge of various recombinant vaccines and on the potential for the development of novel multivalent vaccines for small ruminants. PMID:26443889

  8. Peste des petits ruminants.

    PubMed

    Parida, S; Muniraju, M; Mahapatra, M; Muthuchelvan, D; Buczkowski, H; Banyard, A C

    2015-12-14

    Peste des petits ruminants virus causes a highly infectious disease of small ruminants that is endemic across Africa, the Middle East and large regions of Asia. The virus is considered to be a major obstacle to the development of sustainable agriculture across the developing world and has recently been targeted by the World Organisation for Animal Health (OIE) and the Food and Agriculture Organisation (FAO) for eradication with the aim of global elimination of the disease by 2030. Fundamentally, the vaccines required to successfully achieve this goal are currently available, but the availability of novel vaccine preparations to also fulfill the requisite for differentiation between infected and vaccinated animals (DIVA) may reduce the time taken and the financial costs of serological surveillance in the later stages of any eradication campaign. Here, we overview what is currently known about the virus, with reference to its origin, updated global circulation, molecular evolution, diagnostic tools and vaccines currently available to combat the disease. Further, we comment on recent developments in our knowledge of various recombinant vaccines and on the potential for the development of novel multivalent vaccines for small ruminants.

  9. 78 FR 71024 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-27

    ....gov , including any personal information you provide. Using the search function of our docket Web site..., Engine and Propeller Directorate, Standards Staff, ANE- 111, 12 New England Executive Park, Burlington... Rulemaking. Petition for Exemption Docket No.: FAA-2013-0815 Petitioner: International Aero Engines,...

  10. 78 FR 59753 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-27

    ... Building Ground Floor at 1200 New Jersey Avenue SE., Washington, DC, between 9 a.m. and 5 p.m., Monday... West Building Ground Floor at 1200 New Jersey Avenue SE., Washington, DC, between 9 a.m. and 5 p.m... Rulemaking. Petition for Exemption Docket No.: FAA-2013-0779. Petitioner: Orbital Science...

  11. 77 FR 4394 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-27

    .... Petition for Exemption Docket No.: FAA-2011-1361. Petitioner: Southwest Airlines Co. Section of 14 CFR Affected: 14 CFR 121.163(a) Description of Relief Sought: Southwest Airlines requests to extend the date by which proving runs for the Boeing 717 aircraft must be accomplished. Specifically, Southwest requests...

  12. 77 FR 64581 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    ... activities. Neither publication of this notice nor the inclusion or omission of information in the summary is... Rulemaking. Petition for Exemption Docket No.: FAA-2012-0815. Petitioner: Aero Sports Connection, Inc. Section of 14 CFR Affected: 14 CFR 103.1(e)(1). Description of Relief Sought: Aero Sports...

  13. 77 FR 67438 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-09

    ... contains a summary of a petition seeking relief from specified requirements of 14 CFR. The purpose of this....S. Department of Transportation, 1200 New Jersey Avenue SE., West Building Ground Floor, Room W12... Delivery: Bring comments to the Docket Management Facility in Room W12-140 of the West Building...

  14. 76 FR 61473 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-04

    ... contains a summary of a petition seeking relief from specified requirements of 14 CFR. The purpose of this....S. Department of Transportation, 1200 New Jersey Avenue, SE., West Building Ground Floor, Room W12... Delivery: Bring comments to the Docket Management Facility in Room W12-140 of the West Building...

  15. 76 FR 78330 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-16

    ... contains a summary of a petition seeking relief from specified requirements of 14 CFR. The purpose of this.... Department of Transportation, 1200 New Jersey Avenue SE., West Building Ground Floor, Room W12-140...: Bring comments to the Docket Management Facility in Room W12-140 of the West Building Ground Floor...

  16. 78 FR 68135 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-13

    ... contains a summary of a petition seeking relief from specified requirements of 14 CFR. The purpose of this.... Department of Transportation, 1200 New Jersey Avenue SE., West Building Ground Floor, Room W12-140...: Bring comments to the Docket Management Facility in Room W12-140 of the West Building Ground Floor...

  17. 76 FR 38266 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    ... contains a summary of a petition seeking relief from specified requirements of 14 CFR. The purpose of this.... Department of Transportation, 1200 New Jersey Avenue, SE., West Building Ground Floor, Room W12-140...: Bring comments to the Docket Management Facility in Room W12-140 of the West Building Ground Floor...

  18. 78 FR 7477 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-01

    ... contains a summary of a petition seeking relief from specified requirements of 14 CFR. The purpose of this.... Department of Transportation, 1200 New Jersey Avenue SE., West Building Ground Floor, Room W12-140...: Bring comments to the Docket Management Facility in Room W12-140 of the West Building Ground Floor...

  19. 75 FR 2925 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-19

    ... contains a summary of a petition seeking relief from specified requirements of 14 CFR. The purpose of this....S. Department of Transportation, 1200 New Jersey Avenue, SE., West Building Ground Floor, Room W12... Delivery: Bring comments to the Docket Management Facility in Room W12-140 of the West Building...

  20. 77 FR 29444 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-17

    ... contains a summary of a petition seeking relief from specified requirements of 14 CFR. The purpose of this... Transportation, 1200 New Jersey Avenue SE., West Building Ground Floor, Room W12-140, Washington, DC 20590. Fax... Docket Management Facility in Room W12-140 of the West Building Ground Floor at 1200 New Jersey Avenue...

  1. 76 FR 38265 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    ... contains a summary of a petition seeking relief from specified requirements of 14 CFR. The purpose of this.... Department of Transportation, 1200 New Jersey Avenue, SE., West Building Ground Floor, Room W12-140...: Bring comments to the Docket Management Facility in Room W12-140 of the West Building Ground Floor...

  2. 75 FR 32837 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-09

    ... contains a summary of a petition seeking relief from specified requirements of 14 CFR. The purpose of this.... Department of Transportation, 1200 New Jersey Avenue, SE., West Building Ground Floor, Room W12-140...: Bring comments to the Docket Management Facility in Room W12-140 of the West Building Ground Floor...

  3. 76 FR 78330 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-16

    ... contains a summary of a petition seeking relief from specified requirements of 14 CFR. The purpose of this....S. Department of Transportation, 1200 New Jersey Avenue SE., West Building Ground Floor, Room W12... Delivery: Bring comments to the Docket Management Facility in Room W12-140 of the West Building...

  4. 29 CFR 2200.91 - Discretionary review; petitions for discretionary review; statements in opposition to petitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... it can be given. A petition for discretionary review may be conditional, and may state that review is... petition should state why review should be directed, including: Whether the Judge's decision raises an.... A petition should concisely state the portions of the decision for which review is sought and...

  5. 37 CFR 41.3 - Petitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... review. (d) Effect on proceeding. The filing of a petition does not stay the time for any other action in... section covers petitions on matters pending before the Board (§§ 41.35, 41.64, 41.103, and 41.205); otherwise, see §§ 1.181 to 1.183 of this title. The following matters are not subject to petition:...

  6. 47 CFR 69.707 - Geographic scope of petition.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) ACCESS CHARGES Pricing Flexibility § 69.707 Geographic scope of petition. (a) MSA. (1) A price cap LEC filing a petition for pricing flexibility in an MSA shall include data sufficient to support its petition... flexibility for two or more MSAs in a single petition, provided that it submits supporting data...

  7. 47 CFR 69.707 - Geographic scope of petition.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) ACCESS CHARGES Pricing Flexibility § 69.707 Geographic scope of petition. (a) MSA. (1) A price cap LEC filing a petition for pricing flexibility in an MSA shall include data sufficient to support its petition... flexibility for two or more MSAs in a single petition, provided that it submits supporting data...

  8. 47 CFR 69.707 - Geographic scope of petition.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) ACCESS CHARGES Pricing Flexibility § 69.707 Geographic scope of petition. (a) MSA. (1) A price cap LEC filing a petition for pricing flexibility in an MSA shall include data sufficient to support its petition... flexibility for two or more MSAs in a single petition, provided that it submits supporting data...

  9. 47 CFR 69.707 - Geographic scope of petition.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) ACCESS CHARGES Pricing Flexibility § 69.707 Geographic scope of petition. (a) MSA. (1) A price cap LEC filing a petition for pricing flexibility in an MSA shall include data sufficient to support its petition... flexibility for two or more MSAs in a single petition, provided that it submits supporting data...

  10. 49 CFR 552.15 - Processing of petition.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) NHTSA will process any petition that contains the information specified by this subpart. If a petition fails to provide any of the information, NHTSA will not process the petition but will advise the petitioner of the information that shall be provided if the agency is to process the petition. The...

  11. 49 CFR 552.15 - Processing of petition.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) NHTSA will process any petition that contains the information specified by this subpart. If a petition fails to provide any of the information, NHTSA will not process the petition but will advise the petitioner of the information that shall be provided if the agency is to process the petition. The...

  12. 49 CFR 552.15 - Processing of petition.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) NHTSA will process any petition that contains the information specified by this subpart. If a petition fails to provide any of the information, NHTSA will not process the petition but will advise the petitioner of the information that shall be provided if the agency is to process the petition. The...

  13. 43 CFR 14.4 - Publication of petitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Publication of petitions. 14.4 Section 14.4 Public Lands: Interior Office of the Secretary of the Interior PETITIONS FOR RULEMAKING § 14.4 Publication of petitions. A petition for rulemaking may be published in the Federal Register if the...

  14. 1869 Petition: The Appeal for Woman Suffrage. Teaching with Documents.

    ERIC Educational Resources Information Center

    Haverkamp, Beth, Ed.; And Others

    1995-01-01

    Maintains that between 1848 and 1920 when the 19th Amendment was ratified, women repeatedly petitioned both state and federal governments for the right to vote. Presents a lesson plan on a women's suffrage petition submitted to Congress in 1869. Includes the background of the petition, the petition's text, and suggested teaching activities. (CFR)

  15. 8 CFR 204.6 - Petitions for employment creation aliens.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Petitions for employment creation aliens. 204.6 Section 204.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRANT PETITIONS Immigrant Visa Petitions § 204.6 Petitions for employment creation aliens. (a)...

  16. 8 CFR 204.6 - Petitions for employment creation aliens.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Petitions for employment creation aliens. 204.6 Section 204.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRANT PETITIONS Immigrant Visa Petitions § 204.6 Petitions for employment creation aliens. (a)...

  17. 8 CFR 204.6 - Petitions for employment creation aliens.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Petitions for employment creation aliens. 204.6 Section 204.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRANT PETITIONS Immigrant Visa Petitions § 204.6 Petitions for employment creation aliens. (a)...

  18. 8 CFR 204.6 - Petitions for employment creation aliens.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Petitions for employment creation aliens. 204.6 Section 204.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRANT PETITIONS Immigrant Visa Petitions § 204.6 Petitions for employment creation aliens. (a)...

  19. 8 CFR 204.6 - Petitions for employment creation aliens.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Petitions for employment creation aliens. 204.6 Section 204.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRANT PETITIONS Immigrant Visa Petitions § 204.6 Petitions for employment creation aliens. (a)...

  20. 40 CFR 82.120 - Petitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 17 2011-07-01 2011-07-01 false Petitions. 82.120 Section 82.120 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PROTECTION OF STRATOSPHERIC OZONE The Labeling of Products Using Ozone-Depleting Substances § 82.120 Petitions....

  1. 40 CFR 82.120 - Petitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Petitions. 82.120 Section 82.120 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PROTECTION OF STRATOSPHERIC OZONE The Labeling of Products Using Ozone-Depleting Substances § 82.120 Petitions....

  2. 75 FR 41529 - Petitions for Modification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-16

    ... Safety and Health Administration Petitions for Modification AGENCY: Mine Safety and Health Administration (MSHA), Labor. ACTION: Notice of petitions for modification of existing mandatory safety standards. SUMMARY: Section 101(c) of the Federal Mine Safety and Health Act of 1977 and 30 CFR part 44 govern...

  3. EPA's Denial of Petitions for Reconsideration of the Final Rule Establishing the 2013 Biomass-Based Diesel Volume Documents under the Renewable Fuel Standard Program

    EPA Pesticide Factsheets

    EPA is denying two petitions for reconsideration of the final rule entitled Regulation of Fuels and Fuel Additives: 2013 Biomass-Based Diesel Renewable Fuel Volume. Find the documents supporting this notice here.

  4. Spatio-temporal analysis of human electroencephalograms: Petit-mal epilepsy

    NASA Astrophysics Data System (ADS)

    Friedrich, R.; Uhl, C.

    An analysis of multigrid electroencephalograms (EEG) derived from two different persons suffering from petit-mal epilepsy is performed. Using a previously devised method for analyzing spatio-temporal patterns (Uhl, et al., Z. Phys. B 92 (1993) 211-219), we find a suitable mode decomposition of the EEG. Additionally, we are able to extract a three-dimensional dynamical system which describes the dynamics of the patterns as a kind of mode interaction. We show that the spike-wave behavior characteristic for petit-mal epilepsy arising in the dynamical system is related with Sil'nikov-type behavior of the mode dynamics.

  5. Petit receives Robert C. Cowen Award for Sustained Achievement in Science Journalism: Response

    NASA Astrophysics Data System (ADS)

    Petit, Charles W.

    2012-01-01

    Charles W. Petit, a veteran science writer, received the 2011 Robert C. Cowan Award for Sustained Achievement in Science Journalism at the AGU Fall Meeting Honors Ceremony, held on 7 December 2011 in San Francisco, Calif. Petit covered earthquakes for the San Francisco Chronicle during the 1980s and 1990s and has recently served as "head tracker" for the Knight Science Journalism Tracker, a Massachusetts Institute of Technology-based daily blog that compiles and critiques science reporting worldwide. Petit was previously honored by AGU in 2003 when he received the David Perlman Award for an article about a new finding in oceanography. The Cowan Award, named for a former science editor of the Christian Science Monitor, is given no more than every 2 years and recognizes a journalist who has made "significant, lasting, and consistent contributions to accurate reporting or writing" on the Earth and space sciences for the general public.

  6. Petit receives Robert C. Cowen Award for Sustained Achievement in Science Journalism: Citation

    NASA Astrophysics Data System (ADS)

    Rademacher, Horst

    2012-01-01

    Charles W. Petit, a veteran science writer, received the 2011 Robert C. Cowan Award for Sustained Achievement in Science Journalism at the AGU Fall Meeting Honors Ceremony, held on 7 December 2011 in San Francisco, Calif. Petit covered earthquakes for the San Francisco Chronicle during the 1980s and 1990s and has recently served as "head tracker" for the Knight Science Journalism Tracker, a Massachusetts Institute of Technology-based daily blog that compiles and critiques science reporting worldwide. Petit was previously honored by AGU in 2003 when he received the David Perlman Award for an article about a new finding in oceanography. The Cowan Award, named for a former science editor of the Christian Science Monitor, is given no more than every 2 years and recognizes a journalist who has made "significant, lasting, and consistent contributions to accurate reporting or writing" on the Earth and space sciences for the general public.

  7. EPA Response to Petition from Biogenic CO2 Coalition (December 21, 2016)

    EPA Pesticide Factsheets

    This page is a response to the Biogenic CO2 Coalition’s petition for reconsideration of the final finding that greenhouse gas emissions from aircraft cause or contribute to air pollution that may reasonably be anticipated to endanger public health and

  8. 78 FR 31579 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Petition...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-24

    ... Security Act ACTION: Notice. SUMMARY: The Department of Labor (DOL) is submitting the Employee Benefits Security Administration (EBSA) sponsored information collection request (ICR) titled, ``Petition for Finding under Employee Retirement Income Security Act Section 3(40),'' to the Office of Management...

  9. 14 CFR 11.101 - May I ask FAA to reconsider my petition for rulemaking or petition for exemption if it is denied?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... rulemaking or petition for exemption if it is denied? 11.101 Section 11.101 Aeronautics and Space FEDERAL... petition for rulemaking or petition for exemption if it is denied? Yes, you may petition FAA to reconsider... petition, and FAA must receive it within 60 days after we issued the denial. For us to accept your...

  10. 21 CFR 509.5 - Petitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... RELATED PRODUCTS UNAVOIDABLE CONTAMINANTS IN ANIMAL FOOD AND FOOD-PACKAGING MATERIAL General Provisions... interested person who has submitted a petition, may issue a proposal to establish, revoke, or amend...

  11. 25 CFR 82.6 - Petition format.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... as many pages as are necessary to accommodate the signatures of the petitioners. However, each sheet... the date upon which the petition was signed by each individual as well as the current mailing...

  12. Portable device for detection of petit mal epilepsy

    NASA Technical Reports Server (NTRS)

    Smith, R. G.; Houge, J. C.; Webster, J. G.

    1979-01-01

    A portable device that analyzes the electroencephalogram to determine if petit mal epilepsy waveforms are present is developed and tested. Clinicians should find it useful in diagnosing seizure activity of their patients. The micropower, battery-operated, portable device indicates a seizure has occurred if three criteria are satisfied: (1) frequencies of 2.5-7 Hz, (2) large-amplitude waves, and (3) minimum number of waves per second. Levels and counts are adjustable, thus insuring high reliability against noise artifacts and permitting each subject to be individually fitted. The device has shown promise in giving the patient a possible mechanism of seizure control or suppression.

  13. 42 CFR Appendix C to Part 130 - Petition Form, Petition Instructions, and Documentation Checklist

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Petition Form, Petition Instructions, and Documentation Checklist C Appendix C to Part 130 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES COMPASSIONATE PAYMENTS RICKY RAY HEMOPHILIA RELIEF FUND PROGRAM Pt. 130, App. C...

  14. 42 CFR Appendix C to Part 130 - Petition Form, Petition Instructions, and Documentation Checklist

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Petition Form, Petition Instructions, and Documentation Checklist C Appendix C to Part 130 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES COMPASSIONATE PAYMENTS RICKY RAY HEMOPHILIA RELIEF FUND PROGRAM Pt. 130, App. C...

  15. 42 CFR Appendix C to Part 130 - Petition Form, Petition Instructions, and Documentation Checklist

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Petition Form, Petition Instructions, and Documentation Checklist C Appendix C to Part 130 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES COMPASSIONATE PAYMENTS RICKY RAY HEMOPHILIA RELIEF FUND PROGRAM Pt. 130, App. C...

  16. 42 CFR Appendix C to Part 130 - Petition Form, Petition Instructions, and Documentation Checklist

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Petition Form, Petition Instructions, and Documentation Checklist C Appendix C to Part 130 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES COMPASSIONATE PAYMENTS RICKY RAY HEMOPHILIA RELIEF FUND PROGRAM Pt. 130, App. C...

  17. 42 CFR Appendix C to Part 130 - Petition Form, Petition Instructions, and Documentation Checklist

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Petition Form, Petition Instructions, and Documentation Checklist C Appendix C to Part 130 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES COMPASSIONATE PAYMENTS RICKY RAY HEMOPHILIA RELIEF FUND PROGRAM Pt. 130, App. C...

  18. 5 CFR 1201.114 - Petition and cross petition for review-content and procedure.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... petition for review, or a response to a petition for review, whether computer generated, typed, or... review is limited to 15 pages or 3750 words, whichever is less. Computer generated and typed pleadings... of OPM. The Director of OPM may intervene in a case before the Board under the standards stated in...

  19. 76 FR 77533 - Mandatory Electronic Filing for Cable Special Relief Petitions and Cable Show Cause Petitions...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-13

    ...: This document announces the implementation of electronic filing of Cable Special Relief (CSR) Petitions... filing of CSR and CSC petitions will be permitted through January 3, 2012, when electronic filing will... Tillery of the Media Bureau at (202) 418-1056. SUPPLEMENTARY INFORMATION: This is a summary of the CSR...

  20. 78 FR 23826 - Information Collection Activities (Complaints, Petitions for Declaratory Orders, and Petitions...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-22

    ... complaints (5)). Total ``Non-hour Burden'' Cost (such as printing, mailing, and messenger costs): $7,310... printing, mailing, and messenger costs): $8,652 (estimated ``non-hour burden'' cost per petition ($1,236) x... printing, mailing, and messenger costs): $630 (estimated ``non-hour burden'' cost per petition ($70)...

  1. Clean Power Plan Petitions for Reconsideration January 2017

    EPA Pesticide Factsheets

    This page includes information about EPA's response to petitions to reconsider and petitions to stay the Clean Power Plan, including the Federal Register Notice and a memorandum and appendices supporting the response.

  2. 19 CFR 171.1 - Petition for relief.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... non-commercial violations, a non-English speaking petitioner or petitioner who has a disability which... support of the petition be in English or be accompanied by an English translation. The petition must...

  3. 19 CFR 171.1 - Petition for relief.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... non-commercial violations, a non-English speaking petitioner or petitioner who has a disability which... support of the petition be in English or be accompanied by an English translation. The petition must...

  4. 19 CFR 171.1 - Petition for relief.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... non-commercial violations, a non-English speaking petitioner or petitioner who has a disability which... support of the petition be in English or be accompanied by an English translation. The petition must...

  5. 19 CFR 171.1 - Petition for relief.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... non-commercial violations, a non-English speaking petitioner or petitioner who has a disability which... support of the petition be in English or be accompanied by an English translation. The petition must...

  6. 77 FR 65332 - Rulemaking Petition: Electioneering Communications Reporting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-26

    ...; ] FEDERAL ELECTION COMMISSION 11 CFR Part 104 Rulemaking Petition: Electioneering Communications Reporting.... See REG 2012-01 Electioneering Communications Reporting (2012). The Petition urges the Commission to revise the regulations regarding the reporting of electioneering communications. DATES: Statements...

  7. 75 FR 8843 - Sherwood Martinelli; Receipt of Petition for Rulemaking

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-26

    ... docketed by the NRC on December 24, 2009, and has been assigned Docket No. PRM-50-94. The petitioner... petition has been docketed as PRM-50-94. The NRC is requesting public comment on the petition...

  8. 22 CFR 42.41 - Effect of approved petition.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Effect of approved petition. 42.41 Section 42.41 Foreign Relations DEPARTMENT OF STATE VISAS VISAS: DOCUMENTATION OF IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Petitions § 42.41 Effect of approved petition. Consular officers are authorized to grant to an alien the...

  9. 77 FR 76596 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-28

    ..., the Akron Barberton Cluster Railway (AB) petitioned the Federal Railroad Administration (FRA) for an... at 49 U.S.C. 21103(a)(4). FRA assigned the petition Docket Number FRA-2010-0144. In its petition, AB... duty after initiating an on-duty period for 6 consecutive days. Specifically, AB seeks an extension...

  10. 32 CFR 150.22 - Petitions for new trial.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Petitions for new trial. 150.22 Section 150.22... MILITARY JUSTICE COURTS OF CRIMINAL APPEALS RULES OF PRACTICE AND PROCEDURE § 150.22 Petitions for new... counsel for the accused, a petition for new trial submitted while the accused's case is undergoing...

  11. 78 FR 25347 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-30

    ... TRANSPORTATION Federal Railroad Administration Petition for Waiver of Compliance In accordance with Part 211 of... petition, as well as any written communications concerning the petition, is available for review online at www.regulations.gov and in person at the U.S. Department of Transportation's Docket...

  12. 21 CFR 101.69 - Petitions for nutrient content claims.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Petitions for nutrient content claims. 101.69... (CONTINUED) FOOD FOR HUMAN CONSUMPTION FOOD LABELING Specific Requirements for Nutrient Content Claims § 101.69 Petitions for nutrient content claims. (a) This section pertains to petitions for...

  13. 21 CFR 101.69 - Petitions for nutrient content claims.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Petitions for nutrient content claims. 101.69... (CONTINUED) FOOD FOR HUMAN CONSUMPTION FOOD LABELING Specific Requirements for Nutrient Content Claims § 101.69 Petitions for nutrient content claims. (a) This section pertains to petitions for...

  14. 21 CFR 101.69 - Petitions for nutrient content claims.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Petitions for nutrient content claims. 101.69... (CONTINUED) FOOD FOR HUMAN CONSUMPTION FOOD LABELING Specific Requirements for Nutrient Content Claims § 101.69 Petitions for nutrient content claims. (a) This section pertains to petitions for...

  15. 16 CFR 1702.19 - Effect of filing petition.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Effect of filing petition. 1702.19 Section 1702.19 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION...

  16. 16 CFR 1702.19 - Effect of filing petition.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Effect of filing petition. 1702.19 Section 1702.19 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION...

  17. 16 CFR 1702.19 - Effect of filing petition.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Effect of filing petition. 1702.19 Section 1702.19 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION...

  18. 16 CFR 1702.19 - Effect of filing petition.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Effect of filing petition. 1702.19 Section 1702.19 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION...

  19. 14 CFR 1245.111 - Submission of petitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Submission of petitions. 1245.111 Section 1245.111 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PATENTS AND OTHER INTELLECTUAL PROPERTY RIGHTS Patent Waiver Regulations § 1245.111 Submission of petitions. (a) Petitions...

  20. 14 CFR 1245.111 - Submission of petitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Submission of petitions. 1245.111 Section 1245.111 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PATENTS AND OTHER INTELLECTUAL PROPERTY RIGHTS Patent Waiver Regulations § 1245.111 Submission of petitions. (a) Petitions...

  1. 40 CFR 152.99 - Petitions to cancel registration.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Petitions to cancel registration. 152... PROGRAMS PESTICIDE REGISTRATION AND CLASSIFICATION PROCEDURES Procedures To Ensure Protection of Data Submitters' Rights § 152.99 Petitions to cancel registration. An original data submitter may petition...

  2. 77 FR 2935 - Mars, Inc.; Filing of Color Additive Petition

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-20

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 73 Mars, Inc.; Filing of Color Additive Petition... Administration (FDA) is announcing that Mars, Inc., has filed a petition proposing that the color additive... additive petition (CAP 2C0293) has been filed by Mars, Inc., c/o Keller and Heckman LLP, 1001 G St....

  3. 27 CFR 72.35 - Time of filing petition.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false Time of filing petition. 72.35 Section 72.35 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU... Remission or Mitigation of Forfeitures § 72.35 Time of filing petition. A petition may be filed at any...

  4. 21 CFR 171.7 - Withdrawal of petition without prejudice.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Withdrawal of petition without prejudice. 171.7... (CONTINUED) FOOD ADDITIVE PETITIONS General Provisions § 171.7 Withdrawal of petition without prejudice. (a.... This withdrawal will be without prejudice to a future filing. Upon refiling, the time limitation...

  5. 78 FR 48766 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-09

    ... June 24, 2013, Canadian Pacific Railway (CP) has petitioned the Federal Railroad Administration (FRA... States Rail Operations. FRA assigned the petition Docket Number FRA-2003-15010. In its petition, CP... desk, located in CP's Network Management Center in Montreal, QC, Canada. CP operates approximately...

  6. 27 CFR 9.13 - Initial processing of AVA petitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Initial processing of AVA petitions. 9.13 Section 9.13 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU... petition. When a perfected petition is accepted for rulemaking, TTB will place a notice to that effect...

  7. 27 CFR 9.13 - Initial processing of AVA petitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Initial processing of AVA petitions. 9.13 Section 9.13 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU... petition. When a perfected petition is accepted for rulemaking, TTB will place a notice to that effect...

  8. 7 CFR 1580.201 - Petitions for trade adjustment assistance.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Petitions for trade adjustment assistance. 1580.201... SERVICE, DEPARTMENT OF AGRICULTURE TRADE ADJUSTMENT ASSISTANCE FOR FARMERS § 1580.201 Petitions for trade... States or their authorized representative may file a petition for trade adjustment assistance....

  9. 21 CFR 60.34 - FDA action on petitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... determined that the applicant did not act with due diligence during the applicable regulatory review period; or (5) The petition fails to allege a sufficient total amount of time during which the applicant did... petition filed under § 60.30(a), the agency will either deny the petition under paragraph (b) or (c)...

  10. 77 FR 36935 - Petition for Approval of Alternate Odometer Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-20

    ...The State of Florida (``Florida'') has petitioned for approval of alternate odometer requirements. Florida's petition \\1\\ is granted as to vehicle transfers involving casual or private sales, and Florida's petition is denied as to sales involving licensed dealers and sales of leased vehicles....

  11. 29 CFR 1614.304 - Contents of petition.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Contents of petition. 1614.304 Section 1614.304 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION FEDERAL SECTOR EQUAL EMPLOYMENT OPPORTUNITY Related Processes § 1614.304 Contents of petition. (a) Form. Petitions must be written or typed, but may use any format...

  12. 21 CFR 171.6 - Amendment of petition.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Amendment of petition. 171.6 Section 171.6 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) FOOD ADDITIVE PETITIONS General Provisions § 171.6 Amendment of petition. After...

  13. 21 CFR 171.7 - Withdrawal of petition without prejudice.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) FOOD ADDITIVE PETITIONS General Provisions § 171.7... limitation will begin to run anew. (c) Any petitioner who has a food additive petition pending before the... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Withdrawal of petition without prejudice....

  14. 21 CFR 171.7 - Withdrawal of petition without prejudice.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) FOOD ADDITIVE PETITIONS General Provisions § 171.7... limitation will begin to run anew. (c) Any petitioner who has a food additive petition pending before the... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Withdrawal of petition without prejudice....

  15. 49 CFR 525.6 - Requirements for petition.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... for petition. Each petition filed under this part must— (a) Identify the model year or years for which exemption is requested; (b) Be submitted not later than 24 months before the beginning of the affected model... the petition, and the name and address of the manufacturer; (f) Set forth in full data, views...

  16. 39 CFR 961.5 - Effect of Petition filing.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Effect of Petition filing. 961.5 Section 961.5 Postal Service UNITED STATES POSTAL SERVICE PROCEDURES RULES OF PRACTICE IN PROCEEDINGS RELATIVE TO EMPLOYEE HEARING PETITIONS UNDER SECTION 5 OF THE DEBT COLLECTION ACT § 961.5 Effect of Petition...

  17. 39 CFR 961.5 - Effect of Petition filing.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Effect of Petition filing. 961.5 Section 961.5 Postal Service UNITED STATES POSTAL SERVICE PROCEDURES RULES OF PRACTICE IN PROCEEDINGS RELATIVE TO EMPLOYEE HEARING PETITIONS UNDER SECTION 5 OF THE DEBT COLLECTION ACT § 961.5 Effect of Petition...

  18. 22 CFR 42.41 - Effect of approved petition.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Effect of approved petition. 42.41 Section 42.41 Foreign Relations DEPARTMENT OF STATE VISAS VISAS: DOCUMENTATION OF IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Petitions § 42.41 Effect of approved petition. Consular...

  19. 39 CFR 961.5 - Effect of Petition filing.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Effect of Petition filing. 961.5 Section 961.5 Postal Service UNITED STATES POSTAL SERVICE PROCEDURES RULES OF PRACTICE IN PROCEEDINGS RELATIVE TO EMPLOYEE HEARING PETITIONS UNDER SECTION 5 OF THE DEBT COLLECTION ACT § 961.5 Effect of Petition...

  20. 28 CFR 51.65 - Who may petition.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Who may petition. 51.65 Section 51.65 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PROCEDURES FOR THE ADMINISTRATION OF SECTION 5 OF THE VOTING RIGHTS ACT OF 1965, AS AMENDED Petition To Change Procedures § 51.65 Who may petition....

  1. 28 CFR 51.66 - Form of petition.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Form of petition. 51.66 Section 51.66 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PROCEDURES FOR THE ADMINISTRATION OF SECTION 5 OF THE VOTING RIGHTS ACT OF 1965, AS AMENDED Petition To Change Procedures § 51.66 Form of petition....

  2. 21 CFR 1316.81 - Handling of petitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    .... Upon receipt of a petition, the custodian or DEA Asset Forfeiture System shall request an appropriate... the Administrator of the DEA, depending upon which agency seized the property. If the petition... custodian or DEA Asset Forfeiture System shall transmit the petition to the U.S. Attorney for the...

  3. 21 CFR 1316.81 - Handling of petitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    .... Upon receipt of a petition, the custodian or DEA Asset Forfeiture System shall request an appropriate... the Administrator of the DEA, depending upon which agency seized the property. If the petition... custodian or DEA Asset Forfeiture System shall transmit the petition to the U.S. Attorney for the...

  4. 21 CFR 1316.81 - Handling of petitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    .... Upon receipt of a petition, the custodian or DEA Asset Forfeiture System shall request an appropriate... the Administrator of the DEA, depending upon which agency seized the property. If the petition... custodian or DEA Asset Forfeiture System shall transmit the petition to the U.S. Attorney for the...

  5. 47 CFR 69.707 - Geographic scope of petition.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) ACCESS CHARGES Pricing Flexibility § 69.707 Geographic scope of petition. (a) MSA. (1) A price cap LEC filing a petition for pricing flexibility in an MSA shall include data sufficient to support its petition, as set forth in this subpart, disaggregated by MSA. (2) A price cap LEC may request...

  6. 30 CFR 700.12 - Petitions to initiate rulemaking.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Petitions to initiate rulemaking. 700.12 Section 700.12 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR GENERAL GENERAL § 700.12 Petitions to initiate rulemaking. (a) Any person may petition the Director to initiate a proceeding for the...

  7. 49 CFR 190.309 - Where to file petitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Where to file petitions. 190.309 Section 190.309 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PROCEDURES Procedures for Adoption of Rules § 190.309 Where to file petitions. Petitions for extension...

  8. 37 CFR 2.111 - Filing petition for cancellation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... fee insufficient to pay for one person to petition for cancellation against at least one class in the... accompanied by fees sufficient to pay for one person to petition for cancellation against at least one class... for one person to petition for cancellation of the registration in at least one class but...

  9. 27 CFR 9.11 - Submission of AVA petitions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... petitions. 9.11 Section 9.11 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL AMERICAN VITICULTURAL AREAS AVA Petitions § 9.11 Submission of AVA... specified in § 9.12. The person submitting the petition is also responsible for providing timely...

  10. 27 CFR 9.11 - Submission of AVA petitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... petitions. 9.11 Section 9.11 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS AMERICAN VITICULTURAL AREAS AVA Petitions § 9.11 Submission of AVA... specified in § 9.12. The person submitting the petition is also responsible for providing timely...

  11. 27 CFR 9.11 - Submission of AVA petitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... petitions. 9.11 Section 9.11 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS AMERICAN VITICULTURAL AREAS AVA Petitions § 9.11 Submission of AVA... specified in § 9.12. The person submitting the petition is also responsible for providing timely...

  12. 27 CFR 9.11 - Submission of AVA petitions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... petitions. 9.11 Section 9.11 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL AMERICAN VITICULTURAL AREAS AVA Petitions § 9.11 Submission of AVA... specified in § 9.12. The person submitting the petition is also responsible for providing timely...

  13. Peste des Petits Ruminants Virus.

    PubMed

    Baron, M D; Diallo, A; Lancelot, R; Libeau, G

    2016-01-01

    Peste des petits ruminants virus (PPRV) causes a severe contagious disease of sheep and goats and has spread extensively through the developing world. Because of its disproportionately large impact on the livelihoods of low-income livestock keepers, and the availability of effective vaccines and good diagnostics, the virus is being targeted for global control and eventual eradication. In this review we examine the origin of the virus and its current distribution, and the factors that have led international organizations to conclude that it is eradicable. We also review recent progress in the molecular and cellular biology of the virus and consider areas where further research is required to support the efforts being made by national, regional, and international bodies to tackle this growing threat.

  14. Petite unification: an alternative viewpoint

    SciTech Connect

    Hung, P.Q.

    1981-05-01

    It is assumed that at some distance scale, not too many orders of magnitude less than the compton wavelength of intermediate bosons W/sup + -/ and Z/sup 0/, the SU(3)/sub c/ x SU(2)/sub L/ x U(1)/sub Y/ gauge theory, characterized by three coupling constants, becomes embedded in a gauge theory G/sub S/ x G/sub W/ characterized by only two coupling constants, g/sub S/ and g/sub W/. The strong group G/sub S/ and weak group G/sub W/ are assumed each to be either simple or pseudo-simple i.e. a direct product of simple groups with identical coupling strengths. Such a possibility is caled petite unification. Any subsequent unification of the strong force with the weak at still shorter distances is left unconsidered. A building-up procedure is adopted, that is to say the available inputs from the low-energy theory SU(3)/sub c/ x SU(2)/sub L/ x U(1)/sub Y/ are used to restrict the choices of G/sub S/ and G/sub W/. The inputs used are the experimental value of sin/sup 2/theta/sub W/ and the known fermion representations. The choices of G/sub W/ are found to be quite restricted. The smallest acceptable G/sub W/ turns out to be (SU(2))/sup 4/, and the most efficient choice of a strong group is SU(4) built a la Pati and Salam, which is the simplest case for which the electroweak U(1)/sub Y/ generator is a linear combination of both G/sub S/ and G/sub W/ generators. Furthermore, leptons provide the fourth color degree of freedom achieving thus an early quark-lepton unification. The phenomenology of the minimal petite unification model SU(4) x (SU(2))/sup 4/ is examined in detail.

  15. Another Alternative: A 90-Day Contractual Detoxification Treatment Program

    ERIC Educational Resources Information Center

    Kahn, Robert B.; And Others

    1978-01-01

    In May 1974, Fresno County's Narcotic Abuse Treatment Program began a 21-day outpatient methadone detoxification treatment modality. The purpose of this paper is to examine this alternative treatment modality, its characteristics, its therapeutic outcomes and the rationale for its use. (Author)

  16. 40 CFR 799.9325 - TSCA 90-day dermal toxicity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...—adrenals, parathyroid, thyroid. (D) Respiratory system—trachea, lungs, pharynx, larynx, nose. (E..., but not be limited to, evaluation of skin and fur, eyes and mucous membranes, respiratory and circulatory effects, autonomic effects such as salivation, central nervous system effects, including...

  17. 40 CFR 799.9325 - TSCA 90-day dermal toxicity.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...—adrenals, parathyroid, thyroid. (D) Respiratory system—trachea, lungs, pharynx, larynx, nose. (E..., but not be limited to, evaluation of skin and fur, eyes and mucous membranes, respiratory and circulatory effects, autonomic effects such as salivation, central nervous system effects, including...

  18. 40 CFR 799.9325 - TSCA 90-day dermal toxicity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...—adrenals, parathyroid, thyroid. (D) Respiratory system—trachea, lungs, pharynx, larynx, nose. (E..., but not be limited to, evaluation of skin and fur, eyes and mucous membranes, respiratory and circulatory effects, autonomic effects such as salivation, central nervous system effects, including...

  19. 40 CFR 799.9346 - TSCA 90-day inhalation toxicity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... membranes, respiratory and circulatory effects, autonomic effects such as salivation, central nervous system...) Thyroids. (D) Respiratory system. (1) Trachea. (2) Lung. (3) Pharynx. (4) Larynx. (5) Nose. (E..., whatever its size, shape, and density. It is used to predict where in the respiratory tract such...

  20. 40 CFR 799.9325 - TSCA 90-day dermal toxicity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...—adrenals, parathyroid, thyroid. (D) Respiratory system—trachea, lungs, pharynx, larynx, nose. (E..., but not be limited to, evaluation of skin and fur, eyes and mucous membranes, respiratory and circulatory effects, autonomic effects such as salivation, central nervous system effects, including...