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Sample records for 90-minute time-in-bed restriction

  1. Restricting Time in Bed in Early Adolescence Reduces Both NREM and REM Sleep but Does Not Increase Slow Wave EEG

    PubMed Central

    Campbell, Ian G.; Kraus, Amanda M.; Burright, Christopher S.; Feinberg, Irwin

    2016-01-01

    Study Objectives: School night total sleep time decreases across adolescence (9–18 years) by 10 min/year. This decline is comprised entirely of a selective decrease in NREM sleep; REM sleep actually increases slightly. Decreasing sleep duration across adolescence is often attributed to insufficient time in bed. Here we tested whether sleep restriction in early adolescence produces the same sleep stage changes observed on school nights across adolescence. Methods: All-night sleep EEG was recorded in 76 children ranging in age from 9.9 to 14.0 years. Each participant kept 3 different sleep schedules that consisted of 3 nights of 8.5 h in bed followed by 4 nights of either 7, 8.5, or 10 h in bed. Sleep stage durations and NREM delta EEG activity were compared across the 3 time in bed conditions. Results: Shortening time in bed from 10 to 7 hours reduced sleep duration by approximately 2 hours, roughly equal to the decrease in sleep duration we recorded longitudinally across adolescence. However, sleep restriction significantly reduced both NREM (by 83 min) and REM (by 47 min) sleep. Sleep restriction did not affect NREM delta EEG activity. Conclusions: Our findings suggest that the selective NREM reduction and the small increase in REM we observed longitudinally across 9–18 years are not produced by sleep restriction. We hypothesize that the selective NREM decline reflects adolescent brain maturation (synaptic elimination) that reduces the need for the restorative processes of NREM sleep. Citation: Campbell IG, Kraus AM, Burright CS, Feinberg I. Restricting time in bed in early adolescence reduces both NREM and REM sleep but does not increase slow wave EEG. SLEEP 2016;39(9):1663–1670. PMID:27397569

  2. Restricting Time in Bed in Early Adolescence Reduces Both NREM and REM Sleep but Does Not Increase Slow Wave EEG.

    PubMed

    Campbell, Ian G; Kraus, Amanda M; Burright, Christopher S; Feinberg, Irwin

    2016-09-01

    School night total sleep time decreases across adolescence (9-18 years) by 10 min/year. This decline is comprised entirely of a selective decrease in NREM sleep; REM sleep actually increases slightly. Decreasing sleep duration across adolescence is often attributed to insufficient time in bed. Here we tested whether sleep restriction in early adolescence produces the same sleep stage changes observed on school nights across adolescence. All-night sleep EEG was recorded in 76 children ranging in age from 9.9 to 14.0 years. Each participant kept 3 different sleep schedules that consisted of 3 nights of 8.5 h in bed followed by 4 nights of either 7, 8.5, or 10 h in bed. Sleep stage durations and NREM delta EEG activity were compared across the 3 time in bed conditions. Shortening time in bed from 10 to 7 hours reduced sleep duration by approximately 2 hours, roughly equal to the decrease in sleep duration we recorded longitudinally across adolescence. However, sleep restriction significantly reduced both NREM (by 83 min) and REM (by 47 min) sleep. Sleep restriction did not affect NREM delta EEG activity. Our findings suggest that the selective NREM reduction and the small increase in REM we observed longitudinally across 9-18 years are not produced by sleep restriction. We hypothesize that the selective NREM decline reflects adolescent brain maturation (synaptic elimination) that reduces the need for the restorative processes of NREM sleep. © 2016 Associated Professional Sleep Societies, LLC.

  3. Relation between injections before 90-minute angiography and coronary patency: results of the thrombolysis in myocardial infarction 4 trial.

    PubMed

    Gibson, C M; Marble, S J; Rizzo, M J; Moynihan, J; McLean, C; Ryan, K; Sparano, A; Piana, R N; McCabe, C; Cannon, C P

    1997-09-01

    The current goal of thrombolytic therapy is to achieve both full (Thrombolysis in Myocardial Infarction [TIMI] grade 3) and early reperfusion. Newer reperfusion strategies may now achieve a high degree of reperfusion even earlier than the traditional 90-minute end point. To determine whether injections before 90 minutes affect this traditional end point, the relation between the number of injections before 90-minute angiography and patency was examined in the TIMI 4 trial. The number of injections before 90-minute angiography was no different between occluded arteries (TIMI grade 0/1 flow) (2.46 +/- 1.78; n = 94) and patent arteries (TIMI grade 2/3 flow) (2.71 +/- 2.42; n = 295) (p = 0.24). The incidence of any injections before 90 minutes was no different in patent versus closed arteries (80.6% [77/98] vs 72.4% [22/304]; p = 0.10). The number of injections before 90 minutes was insignificantly smaller in patients with TIMI grade 3 flow (2.53 +/- 2.53 [n = 184] vs 2.76 +/- 2.03 [n = 204]; p = 0.31), but the incidence of any injections before 90 minutes was significantly smaller in patients with TIMI grade 3 flow (68.8% [132/192] vs 79.5% [167/210]; p = 0.01). No relation was identified between the number of injections before 90-minute angiography and patency at this traditional time point. This observation justifies the judicious use of a limited number of "earlier snapshots" of the infarct-related artery before 90 minutes to ascertain just how rapidly newer thrombolytic regimens achieve patency. Patients with TIMI grade 3 flow had a slightly lower incidence of injections before 90 minutes, perhaps because they did not require as urgent a definition of coronary anatomy.

  4. 90 Minutes of Moderate-Intensity Exercise does not Attenuate Postprandial Triglycerides in Older Adults.

    PubMed

    Bodell, Nathaniel G; Gillum, Trevor

    2016-01-01

    To determine whether 90 minutes of moderate-intensity exercise, prior to a high fat meal, attenuates postprandial triglycerides (PPT) in older adults. Eight sedentary older adult volunteers (mean ± SD age = 58 ± 8 years, BMI 26.5 ± 4.2); completed two trials consisting of exercise and a no-exercise control. Exercise trials involved 90 minutes of moderate-intensity exercise 60% heart rate reserve (HRR). Following exercise, an overnight fast of 12-16 hours was performed. Participants were given a high fat meal that consisted of 146 grams of CHO, and 92 grams of fat and instructed to rest. Lipid levels were collected at pre-feeding, 1, 2, 3, and 4 hours post feeding. The control trial involved no exercise, performed an overnight fast of 12-16 hours, and was given the high fat meal followed by four hours of rest and data collection. There was no difference in PPT between the control and exercise trials (p < 0.05). Triglycerides (TG) increased in both trials over pre-feeding values (pre-feeding 123.13 ± 65.03 con. 111 ± 53.9 ex., 1hr 161.50 ± 83.77 con. 149 ± 71.03 ex., 2hrs 208.25 ± 120.69 con. 177 ± 97.29 ex., 3hrs 228 ± 146.99 con. 147.25 ± 87.64 ex., 4hrs 211.75 ± 140.15 con. 169.5 ± 68.14 ex). No difference in triglycerides over time was observed among older adults between the exercise and control trials.

  5. 90 Minutes of Moderate-Intensity Exercise does not Attenuate Postprandial Triglycerides in Older Adults

    PubMed Central

    BODELL, NATHANIEL G.; GILLUM, TREVOR

    2016-01-01

    To determine whether 90 minutes of moderate-intensity exercise, prior to a high fat meal, attenuates postprandial triglycerides (PPT) in older adults. Eight sedentary older adult volunteers (mean ± SD age = 58 ± 8 years, BMI 26.5 ± 4.2); completed two trials consisting of exercise and a no-exercise control. Exercise trials involved 90 minutes of moderate-intensity exercise 60% heart rate reserve (HRR). Following exercise, an overnight fast of 12–16 hours was performed. Participants were given a high fat meal that consisted of 146 grams of CHO, and 92 grams of fat and instructed to rest. Lipid levels were collected at pre-feeding, 1, 2, 3, and 4 hours post feeding. The control trial involved no exercise, performed an overnight fast of 12–16 hours, and was given the high fat meal followed by four hours of rest and data collection. There was no difference in PPT between the control and exercise trials (p < 0.05). Triglycerides (TG) increased in both trials over pre-feeding values (pre-feeding 123.13 ± 65.03 con. 111 ± 53.9 ex., 1hr 161.50 ± 83.77 con. 149 ± 71.03 ex., 2hrs 208.25 ± 120.69 con. 177 ± 97.29 ex., 3hrs 228 ± 146.99 con. 147.25 ± 87.64 ex., 4hrs 211.75 ± 140.15 con. 169.5 ± 68.14 ex). No difference in triglycerides over time was observed among older adults between the exercise and control trials. PMID:27990228

  6. Ball-Sport Endurance and Sprint Test (BEAST90): validity and reliability of a 90-minute soccer performance test.

    PubMed

    Williams, Jeremy D; Abt, Grant; Kilding, Andrew E

    2010-12-01

    The aim of this study was to determine the validity and reliability of a 90-minute soccer performance test: Ball-sport Endurance and Sprint Test (BEAST90). Fifteen healthy male amateur soccer players participated and attended 5 testing sessions over a 10-day period to perform physiologic and soccer-specific assessments. This included familiarization sessions and 2 full trials of the BEAST90, separated by 7 days. The total 90-minute distance, mean percent peak heart rate (HRpeak), and estimated percent peak oxygen uptake of the BEAST90 were 8,097 ± 458 m, 85 ± 5% and 82 ± 14%, respectively. Measures obtained from trial 1 and trial 2 were not significantly different (p > 0.05). Reliability of measures over 90 minutes ranged from 0.9-25.5% (% typical error). The BEAST90 protocol replicated soccer match play in terms of time, movement patterns, physical demands (volume and intensity), distances, and mean and HRpeak values, as well as having an aerobic load similar to that observed during a soccer match. Reproducibility of key physical measures during the BEAST90 were mostly high, suggesting good reliability. The BEAST90 could be used in studies that wish to determine the effects of training or nutritional interventions on prolonged intermittent physical performance.

  7. Comparison of three different methods to prevent heat loss in healthy dogs undergoing 90 minutes of general anesthesia.

    PubMed

    Clark-Price, Stuart C; Dossin, Olivier; Jones, Katherine R; Otto, Angela N; Weng, Hsin-Yi

    2013-05-01

    To compare a towel under, a warm water pad under or a forced warm air blanket over dogs as techniques to reduce heat loss during a standardized anesthetic. Prospective, randomized, crossover study. Eight, healthy, mixed breed dogs weighing 16.3-19.6 kg. Dogs were anesthetized four times for 90 minutes. Dogs were placed on a steel table (treatment TA), with a cotton towel (treatment TO) or a circulating warm water pad (treatment WP) between the dog and the table, or with, a towel under the dog and covered with a forced warm air blanket (treatment WAB). Rectal temperature (RT) was recorded at 5 minute intervals. Changes in temperature (ΔRT) were calculated as the RT at a given point subtracted from the RT before anesthesia (baseline) and compared over time. After 90 minutes of anesthesia, the ΔRT was 3.42 °C ± 0.29 for TA, 2.78 °C ± 0.43 for TO, 1.98 °C ± 0.29 for WP, and 0.91 °C ± 0.27 for WAB. Significant differences in ΔRT occurred between TA and WAB at 20 minutes (0.94 °C ± 0.42, p = 0.0206), between TO and WAB at 30 minutes (1.16 °C ± 0.62, p = 0.0063), between WP and WAB at 50 minutes (0.96 °C ± 0.98, p = 0.0249), between TA and WP at 35 minutes (1.19 °C ± 0.54, p = 0.0091), between TO and WP at 70 minutes (1.12 °C ± 0.56, p = 0.0248), and between TA and TO at 75 minutes (0.96 °C ± 0.62, p = 0.0313). These differences in ΔRT between each treatment persisted from the times indicated until the end of the anesthesia. During anesthesia, forced warm air blankets were superior to other methods tested for limiting heat loss. An efficient heat loss technique should be used for anesthesia longer than 20 minutes duration in medium sized dogs. © 2013 The Authors. Veterinary Anaesthesia and Analgesia © 2013 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia.

  8. Sex of college students moderates associations among bedtime, time in bed, and circadian phase angle.

    PubMed

    Van Reen, Eliza; Sharkey, Katherine M; Roane, Brandy M; Barker, David; Seifer, Ronald; Raffray, Tifenn; Bond, Tamara L; Carskadon, Mary A

    2013-12-01

    Sex differences in circadian rhythms have been reported with some conflicting results. The timing of sleep and length of time in bed have not been considered, however, in previous such studies. The current study has 3 major aims: (1) replicate previous studies in a large sample of young adults for sex differences in sleep patterns and dim light melatonin onset (DLMO) phase; (2) in a subsample constrained by matching across sex for bedtime and time in bed, confirm sex differences in DLMO and phase angle of DLMO to bedtime; (3) explore sex differences in the influence of sleep timing and length of time in bed on phase angle. A total of 356 first-year Brown University students (207 women) aged 17.7 to 21.4 years (mean = 18.8 years, SD = 0.4 years) were included in these analyses. Wake time was the only sleep variable that showed a sex difference. DLMO phase was earlier in women than men and phase angle wider in women than men. Shorter time in bed was associated with wider phase angle in women and men. In men, however, a 3-way interaction indicated that phase angles were influenced by both bedtime and time in bed; a complex interaction was not found for women. These analyses in a large sample of young adults on self-selected schedules confirm a sex difference in wake time, circadian phase, and the association between circadian phase and reported bedtime. A complex interaction with length of time in bed occurred for men but not women. We propose that these sex differences likely indicate fundamental differences in the biology of the sleep and circadian timing systems as well as in behavioral choices.

  9. The association between time in bed and obesity risk in young adults.

    PubMed

    Hart, Chantelle N; Larose, Jessica Gokee; Fava, Joseph L; James, Brittany L; Wing, Rena R

    2013-01-01

    Young adults (YA) are at high risk for insufficient sleep and obesity. However, little research has focused on the association between sleep and obesity in this population. The present study examined the association between reported time in bed (TIB) and body mass index (BMI) in YAs. Participants were 250 18-25 year-olds who completed an online survey assessing several factors associated with weight control. After controlling for significant covariates, TIB was significantly associated with BMI. Specifically, "less than 6 hours/night" TIB was associated with increased BMI compared to the referent category (7 to <8 hours/night) (p = .01). Findings demonstrate that young adults who report shorter TIB are more likely to be classified as having higher BMI.

  10. Estimating Child Sleep From Parent Report of Time in Bed: Development and Evaluation of Adjustment Approaches

    PubMed Central

    Lundahl, Alyssa; Molfese, Dennis L.; Waford, Rachel N.; Roman, Adrienne; Gozal, David; Molfese, Victoria J.; Ferguson, Melissa C.

    2014-01-01

    Objective To develop and evaluate adjustment factors to convert parent-reported time in bed to an estimate of child sleep time consistent with objective measurement. Methods A community sample of 217 children aged 4–9 years (mean age = 6.6 years) wore actigraph wristwatches to objectively measure sleep for 7 days while parents completed reports of child sleep each night. After examining the moderators of the discrepancy between parent reports and actigraphy, 3 adjustment factors were evaluated. Results Parent report of child sleep overestimated nightly sleep duration by ∼24 min per night relative to actigraphy. Child age, gender, and sleep quality all had small or nonsignificant associations with correspondence between parent report and actigraph. Empirically derived adjustment factors significantly reduced the discrepancy between parent report and objective measurement. Conclusions Simple adjustment factors can enhance the correspondence and utility of parent reports of child sleep duration for clinical and research purposes. PMID:24781412

  11. Use of a 90-Minute Admission Window and Front-Fill System to Reduce Work Compression on a General Medicine Inpatient Teaching Service.

    PubMed

    Choi, Youngjee; Kim, Daniel; Chong, Hyemi; Mallow, Christopher; Bill, Jason; Fojo, Anthony T; Blanchard, Melvin

    2017-04-01

    Duty hour limits have shortened intern shifts without concurrent reductions in workload, creating work compression. Multiple admissions during shortened shifts can result in poor training experience and patient care. To relieve work compression, improve resident satisfaction, and improve duty hour compliance in an academic internal medicine program. In 2014, interns on general ward services were allotted 90 minutes per admission from 3 pm to 7 pm, when the rate of admissions was high. Additional admissions arriving during the protected period were directed to hospitalists. Resident teams received 2 patients admitted by the night float team to start the call day (front-fill). Of the 51 residents surveyed before and after the implementation of the intervention, 39 (77%) completed both surveys. Respondents reporting an unmanageable workload fell from 14 to 1 (P < .001), and the number of residents reporting that they felt unable to admit patients in a timely manner decreased from 14 to 2 (P < .001). Reports of adequate time with patients increased from 16 to 36 (P < .001), and residents indicating that they had time to learn from patients increased from 19 to 35 (P < .001). Reports of leaving on time after call days rose from 12 to 33 (P < .01), and overall satisfaction increased from 26 to 35 (P = .002). Results were similar when residents were resurveyed 6 months after the intervention. Call day modifications improved resident perceptions of their workload and time for resident learning and patient care.

  12. Associations between time in bed and suicidal thoughts, plans and attempts in Korean adolescents

    PubMed Central

    Kim, Jae-Hyun; Park, Eun-Cheol; Lee, Sang Gyu; Yoo, Ki-Bong

    2015-01-01

    Objectives To examine the hypothesis that respondents with any of three specific sleep patterns would have a higher likelihood of suicidality than those without reports of these patterns in Korean adolescents. Setting Data from the 2011–2013 Korea Youth Risk Behavior Web-based Survey were used. Participants 191 642 subjects were included. The survey's target population was students in grades 7 through 12 in South Korea. Independent variable Sleep time. Primary and secondary outcome measures Suicidal thoughts, plans and attempts. Results The odds of suicidal thoughts in subjects with very short or long time in bed were 1.487-fold higher (95% CI 1.219 to 1.815) or 0.611-fold lower (95% CI 0.460 to 0.811), respectively, than for subjects with 7 h/day in bed; the odds were similar for suicidal plans. The odds of suicidal thoughts in subjects with early or late awakening times were 1.231-fold higher (95% CI 1.050 to 1.442) or 1.528-fold lower (95% CI 1.000 to 2.334), respectively, than for subjects with 7 h/day in bed; these odds were lower for suicidal plans and attempts. The odds of suicidal thoughts in subjects with early bedtime were 1.748-fold higher (95% CI 1.302 to 2.346), the odds of suicidal plans in people with an early bedtime were 2.494-fold higher (95% CI 1.671 to 3.722) and the odds of suicide attempts in subjects with late bedtime were 1.313-fold higher (95% CI 1.005 to 1.716) than for subjects with a bedtime of 23:00. Conclusions The sleep-related time is associated with suicide-related behaviours in Korean adolescents. Multilateral approaches are needed to identify the greatest risk factors for suicidal behaviours. PMID:26341585

  13. Physical activity, subjective sleep quality and time in bed do not vary by moon phase in German adolescents.

    PubMed

    Smith, Maia P; Standl, Marie; Schulz, Holger; Heinrich, Joachim

    2017-06-01

    Lunar periodicity in human biology and behaviour, particularly sleep, has been reported. However, estimated relationships vary in direction (more or less sleep with full moon) if they exist at all, and studies tend to be so small that there is potential for confounding by weekly or monthly cycles. Lunar variation in physical activity has been posited as a driver of this relationship, but is likewise not well studied. We explore the association between lunar cycle, sleep and physical activity in a population-based sample of 1411 Germans age 14-17 years (46% male). Physical activity (daily minutes moderate-to-vigorous activity) was objectively assessed by accelerometry for a total of 8832 days between 2011 and 2014. At the same time, time in bed (h) and subjective sleep quality (1-6) were diaried each morning. In models corrected for confounding, we found that lunar phase was not significantly associated with physical activity, subjective sleep quality or time in bed in either sex, regardless of season. Observed relationships varied randomly in direction between models, suggesting artefact. Thus, this large, objectively-measured and well-controlled population of adolescents displayed no lunar periodicity in objective physical activity, subjective sleep quality or time in bed. © 2016 European Sleep Research Society.

  14. Achievement of a median door-to-balloon time of less than 90 minutes by implementation of organizational changes in the 'Emergency Department to Cath Lab' pathway: a 5-year analysis.

    PubMed

    Comelli, Ivan; Vignali, Luigi; Rolli, Angelo; Lippi, Giuseppe; Cervellin, Gianfranco

    2012-08-01

    At present, most patients presenting directly to emergency departments (EDs) do not meet the recommended door-to-balloon goal of less than 90 minutes for ST-elevation myocardial infarction (STEMI) patients. Until the year 2005, the goal of less than 90 minutes door-to-balloon time has been rarely achieved in our hospital (i.e. 17% of all cases). Some organizational changes - including immediate involvement of the cardiologist in ED - were established to improve our performance. To evaluate the results of these changes, we have measured the intervals pain-to-door, door-to-electrocardiogram (ECG) and ECG-to-balloon for all the consecutive STEMI patients (n = 206) observed in our hospital during three sample months (May to July) of the years 2005 to 2009. We have then calculated the times door-to-balloon and pain-to-balloon (total ischemic time). We have demonstrated that the door-to-balloon time has been progressively reduced to less than 90 minutes in 73% of patients. Only 4.5% of all patients still have a door-to-balloon time greater than 150 minutes (17% in 2005). It is also notable the 60% reduction (from 330 to 140 minutes) of the pain-to-door time, the so-called 'out of hospital avoidable delay', was achieved by a sensitization campaign directed to the whole population of the province. Taken together, all these organizational changes have allowed to reduce the total ischemic time from 465 minutes in year 2005 to 232 minutes in year 2009, thereby demonstrating the effectiveness of our intervention. © 2011 Blackwell Publishing Ltd.

  15. Factors Contributing to Door-to-Balloon Times of ≤90 Minutes in 97% of Patients with ST-Elevation Myocardial Infarction: Our One-Year Experience with a Heart Alert Protocol

    PubMed Central

    Levis, Joel T; Mercer, Mary P; Thanassi, Mark; Lin, James

    2010-01-01

    Context: Prompt percutaneous coronary intervention (PCI) for patients with ST-segment elevation myocardial infarction (STEMI) can significantly reduce mortality and morbidity, although its effectiveness may be limited by delays in delivery. In March 2008, our hospital implemented a Heart Alert protocol to rapidly identify and treat patients with STEMI presenting to our Emergency Department (ED) with PCI, using strategies previously described to reduce door-to-balloon times. Before the Heart Alert protocol start date, patients with STEMI presenting to our ED were treated with thrombolysis. Objective: We evaluated data from patients with STEMI after one year of use of our Heart Alert protocol to determine protocol success on the basis of the percentage of patients for whom the recommended door-to-balloon times of ≤90 minutes were met. We examined factors involved in implementation of the protocol that contributed to these results. Design: We conducted a retrospective data and chart review for patients in the ED with STEMI who underwent PCI after a Heart Alert protocol activation between March 17, 2008, and March 17, 2009. Results: During the study period, our staff met the recommended door-to-balloon time of ≤90 minutes (mean door-to-balloon time, 57.3 ± 17.6 minutes) for 70 of 72 patients (97%) presenting to our ED with STEMI. Sixty-five of the 72 patients (90.3%) survived to hospital discharge. Conclusion: Initiation of a Heart Alert protocol at our hospital resulted in achievement of door-to-balloon times of ≤90 minutes for 97% of patients with STEMI. This achievement was obtained through careful preparation, training, and interdepartmental collaboration and occurred despite immediate conversion from a previous thrombolytic protocol. PMID:20844699

  16. Self-Reported Sleep Duration and Time in Bed as Predictors of Physical Function Decline: Results from the InCHIANTI Study

    PubMed Central

    Stenholm, Sari; Kronholm, Erkki; Bandinelli, Stefania; Guralnik, Jack M.; Ferrucci, Luigi

    2011-01-01

    Study Objectives: To characterize elderly persons into sleep/rest groups based on their self-reported habitual total sleeping time (TST) and habitual time in bed (TIB) and to examine the prospective association between sleep/rest behavior on physical function decline. Design: Population-based InCHIANTI study with 6 years follow-up (Tuscany, Italy). Setting: Community. Participants: Men and women aged ≥ 65 years (n = 751). Measurements and Results: At baseline, participants were categorized into 5 sleep/rest behavior groups according to their self-reported TST and TIB, computed from bedtime and wake-up time. Physical function was assessed at baseline and at 3- and 6-year follow-ups as walking speed, the Short Physical Performance Battery (SPPB), and self-reported mobility disability (ability to walk 400 m or climb one flight of stairs). Both long (≥ 9 h) TST and long TIB predicted accelerated decline in objectively measured physical performance and greater incidence in subjectively assessed mobility disability, but short (≤ 6 h) TST did not. After combining TST and TIB, long sleepers (TST and TIB ≥ 9 h) experienced the greatest decline in physical performance and had the highest risk for incident mobility disability in comparison to mid-range sleepers with 7-8 h TST and TIB. Subjective short sleepers reporting short (≤ 6 h) TST but long (≥ 9 h) TIB showed a greater decline in SPPB score and had a higher risk of incident mobility disability than true short sleepers with short (≤ 6 h) TST and TIB ≤ 8 hours. Conclusions: Extended time in bed as well as long total sleeping time is associated with greater physical function decline than mid-range or short sleep. TIB offers important additive information to the self-reported sleep duration when evaluating the consequences of sleep duration on health and functional status. Citation: Stenholm S; Kronholm K; Bandinelli S; Guralnik JM; Ferrucci. Self-reported sleep duration and time in bed as predictors of

  17. Self-reported sleep duration and time in bed as predictors of physical function decline: results from the InCHIANTI study.

    PubMed

    Stenholm, Sari; Kronholm, Erkki; Bandinelli, Stefania; Guralnik, Jack M; Ferrucci, Luigi

    2011-11-01

    To characterize elderly persons into sleep/rest groups based on their self-reported habitual total sleeping time (TST) and habitual time in bed (TIB) and to examine the prospective association between sleep/rest behavior on physical function decline. Population-based InCHIANTI study with 6 years follow-up (Tuscany, Italy). Community. Men and women aged ≥ 65 years (n = 751). At baseline, participants were categorized into 5 sleep/rest behavior groups according to their self-reported TST and TIB, computed from bedtime and wake-up time. Physical function was assessed at baseline and at 3- and 6-year follow-ups as walking speed, the Short Physical Performance Battery (SPPB), and self-reported mobility disability (ability to walk 400 m or climb one flight of stairs). Both long (≥ 9 h) TST and long TIB predicted accelerated decline in objectively measured physical performance and greater incidence in subjectively assessed mobility disability, but short (≤ 6 h) TST did not. After combining TST and TIB, long sleepers (TST and TIB ≥ 9 h) experienced the greatest decline in physical performance and had the highest risk for incident mobility disability in comparison to mid-range sleepers with 7-8 h TST and TIB. Subjective short sleepers reporting short (≤ 6 h) TST but long (≥ 9 h) TIB showed a greater decline in SPPB score and had a higher risk of incident mobility disability than true short sleepers with short (≤ 6 h) TST and TIB ≤ 8 hours. Extended time in bed as well as long total sleeping time is associated with greater physical function decline than mid-range or short sleep. TIB offers important additive information to the self-reported sleep duration when evaluating the consequences of sleep duration on health and functional status.

  18. Time in bed, sleep quality and associations with cardiometabolic markers in children: the Prevention and Incidence of Asthma and Mite Allergy birth cohort study.

    PubMed

    Berentzen, Nina E; Smit, Henriëtte A; Bekkers, Marga B M; Brunekreef, Bert; Koppelman, Gerard H; De Jongste, Johan C; Kerkhof, Marjan; Van Rossem, Lenie; Wijga, Alet H

    2014-02-01

    We investigated associations of time in bed and multiple sleep quality characteristics with cardiometabolic markers in children. Data from the prevention and incidence of asthma and mite allergy study, a population-based prospective birth-cohort study started in 1996-1997 in the Netherlands, were analysed. In total 1481 children aged 11-12 years completed a questionnaire (including questions on sleep) and underwent a medical examination. We measured body mass index, waist circumference, total- and high-density lipoprotein cholesterol, blood pressure and glycated haemoglobin. Results showed that in girls, some sleep characteristics were related to anthropometrics (body mass index, waist circumference) and cholesterol. Girls who had a long time in bed (11-12.5 h) had 0.16 lower body mass index z-score (95% confidence interval -0.31; -0.01) and 0.99 cm smaller waist circumference (95% confidence interval -2.01; -0.13) compared with girls who spent 10-10.5 h in bed. Girls who went to bed late and rose early had 0.16 mm higher total cholesterol (95% confidence interval 0.01; 0.31) and 0.08 mm higher high-density lipoprotein cholesterol (95% confidence interval 0.01; 0.14) than 'early to bed/early rise' girls. Girls with night-time awakenings had 0.14 mm higher total cholesterol (95% confidence interval 0.03; 0.25) than girls without night-time awakenings. Girls who felt sleepy/tired ≥1 day per week had 0.10 mm lower high-density lipoprotein cholesterol (95% confidence interval -0.16; -0.04) and 0.17 mm higher total cholesterol/high-density lipoprotein cholesterol ratio (95% confidence interval 0.02; 0.32) than girls who did not feel sleepy. No associations were found for boys. Sleep characteristics were not related to blood pressure and glycated haemoglobin, and effect sizes of the associations in girls were small. Therefore, we consider it premature to propose that improved sleep could reduce cardiovascular risk during childhood. © 2013 European Sleep Research

  19. U-shaped associations between time in bed and the physical and mental functioning of Japanese civil servants: the roles of work, family, behavioral and sleep quality characteristics.

    PubMed

    Sekine, M; Tatsuse, T; Cable, N; Chandola, T; Marmot, M

    2014-09-01

    This study aimed to evaluate (i) whether work, family, behavioral and sleep quality characteristics differ among individuals with different time in bed (TIB), and (ii) whether and how much the U-shaped associations between TIB and health can be explained by these characteristics. Participants were 3510 employees (2371 males and 1139 females) aged 20-65 years working in local government in Japan. They completed a questionnaire regarding work, family, and behavioral characteristics. Sleep quality and physical and mental functioning were evaluated using the Pittsburgh Sleep Quality Index and the Short Form 36. High job demands, long work hours, and high work-family conflict were more prevalent among those with short TIB. Those with long TIB had daily drinking habits. Whereas those with short TIB had poor sleep, mainly due to poor subjective sleep quality and daytime dysfunction, those with long TIB had poor sleep, mainly due to long sleep latency, poor sleep efficiency and sleep disturbances. The U-shaped associations between TIB and poor physical and mental health, with the best health observed in those spending ~8 h in bed, weakened considerably after adjustment for sleep quality, followed by work and family characteristics. After adjusting for behavioral characteristics and long-standing illnesses, the associations hardly changed. The U-shaped associations between TIB and health may be explained by U-shaped associations between TIB and poor sleep and psychosocial stress in work and family life. Copyright © 2014 Elsevier B.V. All rights reserved.

  20. Public Speaking 101: In 90 Minutes or Less.

    ERIC Educational Resources Information Center

    Hayward, Pamela A.

    Recently, when employers of entry-level engineers were asked to prioritize the need for further instruction, over 60% of these employers identified communication skills as the primary curricular element needing increased emphasis. Two of the top 10 required skills ranked as important to engineering practice related to making oral presentations.…

  1. NASA/NOAA Electronic Theater: 90 Minutes of Spectacular Visualization

    NASA Technical Reports Server (NTRS)

    Hasler, A. F.

    2004-01-01

    The NASA/NOAA Electronic Theater presents Earth science observations and visualizations from space in a historical perspective. Fly in from outer space to Ashville and the Conference Auditorium. Zoom through the Cosmos to SLC and site of the 2002 Winter Olympics using 1 m IKONOS 'Spy Satellite' data. Contrast the 1972 Apollo 17 'Blue Marble' image of the Earth with the latest US and International global satellite images that allow us to view our Planet from any vantage point. See the latest spectacular images from NASA/NOAA remote sensing missions like Terra, GOES, TRMM, SeaWiFS, & Landsat 7, of storms & fires like Hurricane Isabel and the LA/San Diego Fire Storms of 2003. See how High Definition Television (HDTV) is revolutionizing the way we do science communication. Take the pulse of the planet on a daily, annual and 30-year time scale. See daily thunderstorms, the annual blooming of the northern hemisphere land masses and oceans, fires in Africa, dust storms in Iraq, and carbon monoxide exhaust from global burning. See visualizations featured on Newsweek, TIME, National Geographic, Popular Science covers & National & International Network TV. Spectacular new global visualizations of the observed and simulated atmosphere and Oceans are shown. See the currents and vortexes in the Oceans that bring up the nutrients blooms in response to El Nino/La Nina climate changes. The Etheater will be presented using the latest High Definition TV (HDTV) and video projection technology on a large screen. See the global city lights, and the great NE US blackout of August 2003 observed by the 'night-vision' DMSP satellite.

  2. NASA/NOAA Electronic Theater: 90 Minutes of Spectacular Visualization

    NASA Technical Reports Server (NTRS)

    Hasler, A. F.

    2004-01-01

    The NASA/NOAA Electronic Theater presents Earth science observations and visualizations from space in a historical perspective. Fly in from outer space to Ashville and the Conference Auditorium. Zoom through the Cosmos to SLC and site of the 2002 Winter Olympics using 1 m IKONOS 'Spy Satellite' data. Contrast the 1972 Apollo 17 'Blue Marble' image of the Earth with the latest US and International global satellite images that allow us to view our Planet from any vantage point. See the latest spectacular images from NASA/NOAA remote sensing missions like Terra, GOES, TRMM, SeaWiFS, & Landsat 7, of storms & fires like Hurricane Isabel and the LA/San Diego Fire Storms of 2003. See how High Definition Television (HDTV) is revolutionizing the way we do science communication. Take the pulse of the planet on a daily, annual and 30-year time scale. See daily thunderstorms, the annual blooming of the northern hemisphere land masses and oceans, fires in Africa, dust storms in Iraq, and carbon monoxide exhaust from global burning. See visualizations featured on Newsweek, TIME, National Geographic, Popular Science covers & National & International Network TV. Spectacular new global visualizations of the observed and simulated atmosphere and Oceans are shown. See the currents and vortexes in the Oceans that bring up the nutrients blooms in response to El Nino/La Nina climate changes. The Etheater will be presented using the latest High Definition TV (HDTV) and video projection technology on a large screen. See the global city lights, and the great NE US blackout of August 2003 observed by the 'night-vision' DMSP satellite.

  3. Beneficial impact of sleep extension on fasting insulin sensitivity in adults with habitual sleep restriction.

    PubMed

    Leproult, Rachel; Deliens, Gaétane; Gilson, Médhi; Peigneux, Philippe

    2015-05-01

    A link between sleep loss and increased risk for the development of diabetes is now well recognized. The current study investigates whether sleep extension under real-life conditions is a feasible intervention with a beneficial impact on glucose metabolism in healthy adults who are chronically sleep restricted. Intervention study. Sixteen healthy non-obese volunteers (25 [23, 27.8] years old, 3 men). Two weeks of habitual time in bed followed by 6 weeks during which participants were instructed to increase their time in bed by one hour per day. Continuous actigraphy monitoring and daily sleep logs during the entire study. Glucose and insulin were assayed on a single morning blood sample at the end of habitual time in bed and at the end of sleep extension. Home polysomnography was performed during one weekday of habitual time in bed and after 40 days of sleep extension. Sleep time during weekdays increased (mean actigraphic data: +44 ± 34 minutes, P < 0.0001; polysomnographic data: +49 ± 68 minutes, P = 0.014), without any significant change during weekends. Changes from habitual time in bed to the end of the intervention in total sleep time correlated with changes in glucose (r = +0.53, P = 0.041) and insulin levels (r = -0.60, P = 0.025), as well as with indices of insulin sensitivity (r = +0.76, P = 0.002). In healthy adults who are chronically sleep restricted, a simple low cost intervention such as sleep extension is feasible and is associated with improvements in fasting insulin sensitivity. © 2015 Associated Professional Sleep Societies, LLC.

  4. Behavioral and Physiological Consequences of Sleep Restriction

    PubMed Central

    Banks, Siobhan; Dinges, David F.

    2007-01-01

    Adequate sleep is essential for general healthy functioning. This paper reviews recent research on the effects of chronic sleep restriction on neurobehavioral and physiological functioning and discusses implications for health and lifestyle. Restricting sleep below an individual's optimal time in bed (TIB) can cause a range of neurobehavioral deficits, including lapses of attention, slowed working memory, reduced cognitive throughput, depressed mood, and perseveration of thought. Neurobehavioral deficits accumulate across days of partial sleep loss to levels equivalent to those found after 1 to 3 nights of total sleep loss. Recent experiments reveal that following days of chronic restriction of sleep duration below 7 hours per night, significant daytime cognitive dysfunction accumulates to levels comparable to that found after severe acute total sleep deprivation. Additionally, individual variability in neurobehavioral responses to sleep restriction appears to be stable, suggesting a traitlike (possibly genetic) differential vulnerability or compensatory changes in the neurobiological systems involved in cognition. A causal role for reduced sleep duration in adverse health outcomes remains unclear, but laboratory studies of healthy adults subjected to sleep restriction have found adverse effects on endocrine functions, metabolic and inflammatory responses, suggesting that sleep restriction produces physiological consequences that may be unhealthy. Citation: Banks S; Dinges DF. Behavioral and physiological consequences of sleep restriction. J Clin Sleep Med 2007;3(5):519-528. PMID:17803017

  5. Behavioral and physiological consequences of sleep restriction.

    PubMed

    Banks, Siobhan; Dinges, David F

    2007-08-15

    Adequate sleep is essential for general healthy functioning. This paper reviews recent research on the effects of chronic sleep restriction on neurobehavioral and physiological functioning and discusses implications for health and lifestyle. Restricting sleep below an individual's optimal time in bed (TIB) can cause a range of neurobehavioral deficits, including lapses of attention, slowed working memory, reduced cognitive throughput, depressed mood, and perseveration of thought. Neurobehavioral deficits accumulate across days of partial sleep loss to levels equivalent to those found after 1 to 3 nights of total sleep loss. Recent experiments reveal that following days of chronic restriction of sleep duration below 7 hours per night, significant daytime cognitive dysfunction accumulates to levels comparable to that found after severe acute total sleep deprivation. Additionally, individual variability in neurobehavioral responses to sleep restriction appears to be stable, suggesting a trait-like (possibly genetic) differential vulnerability or compensatory changes in the neurobiological systems involved in cognition. A causal role for reduced sleep duration in adverse health outcomes remains unclear, but laboratory studies of healthy adults subjected to sleep restriction have found adverse effects on endocrine functions, metabolic and inflammatory responses, suggesting that sleep restriction produces physiological consequences that may be unhealthy.

  6. Restrictive cardiomyopathy

    MedlinePlus

    Cardiomyopathy - restrictive; Infiltrative cardiomyopathy; Idiopathic myocardial fibrosis ... In a case of restrictive cardiomyopathy, the heart muscle is of normal size or slightly enlarged. Most of the time, it also pumps normally. However, it does ...

  7. Caloric Restriction

    PubMed Central

    Bales, Connie W.; Kraus, William E.

    2013-01-01

    PURPOSE While the impact of caloric restriction on human health is not fully understood, there is strong evidence to support further studies of its influence on cardiovascular health. The purpose of this review is to update the state of the science by examining the relevant literature regarding calorie restriction effects on aging and cardiovascular health and to discuss the possible role(s) of calorie restriction in preserving cardiovascular function in humans. METHODS For purpose of this review, we have defined calorie restriction as a reduction in energy intake well below the amount of calories that would be consumed ad libitum (≥ 10% in humans, ≥20% in animals). We examined the relevant literature on calorie restriction effects on longevity and cardiovascular health, with an emphasis on the state of the science regarding calorie restriction in humans. We have emphasized the importance of the preliminary and expected findings from the Comprehensive Assessment of the Long-term Effect of Reducing Intake of Energy (CALERIE) trial. RESULTS Evidence from animal studies and a limited number of human trials indicates that calorie restriction has the potential to both delay cardiac aging and help prevent atherosclerotic cardiovascular disease via beneficial effects on blood pressure, lipids, inflammatory processes, and potentially other mechanisms. CONCLUSIONS Based upon its known benefits to cardiometabolic health, including modest calorie restriction in a combined lifestyle program is likely to improve heart health and prevent subsequent cardiovascular events in overweight and obese individuals. Additional study is needed to further illuminate its long-term applicability for older adults and for those with significant comorbidities such as heart failure. PMID:23748374

  8. The impact of increasing sleep restriction on cortisol and daytime sleepiness in adolescents.

    PubMed

    Voderholzer, Ulrich; Piosczyk, Hannah; Holz, Johannes; Feige, Bernd; Loessl, Barbara; Kopasz, Marta; Riemann, Dieter; Nissen, Christoph

    2012-01-24

    Sleep restriction is a widespread phenomenon, specifically in adolescents. This study investigated the impact of increasing sleep restriction in adolescents on cortisol levels and daytime sleepiness. Eighty-eight healthy adolescents were randomized to five sleep restriction protocols (four consecutive nights with 9, 8, 7, 6, or 5 h time in bed). Polysomnography (baseline and last experimental night) and multiple sleep latency test (day 6) data were obtained. Saliva cortisol levels were assessed half-hourly in the evening before and in the morning after the baseline and the last experimental night. Four nights of sleep restriction in healthy adolescents lead to a linear increase of objective sleepiness, but had no significant effect on evening or morning cortisol levels. The lack of detrimental effects of sleep restriction on cortisol levels might be due to compensation mechanisms during sleep.

  9. Restrictive cardiomyopathies.

    PubMed

    Nihoyannopoulos, Petros; Dawson, David

    2009-12-01

    Restrictive cardiomyopathies constitute a heterogenous group of heart muscle conditions that all have, in common, the symptoms of heart failure. Diastolic dysfunction with preserved systolic function is often the only echocardiographic abnormality that may be noted, although systolic dysfunction may also be an integral part of some specific pathologies, particularly in the most advanced cases such as amyloid infiltration of the heart. By far, the majority of restrictive cardiomyopathies are secondary to a systemic disorder such as amyloidosis, sarcoidosis, scleroderma, haemochromatosis, eosinophilic heart disease, or as a result of radiation treatment. The much more rare diagnosis of idiopathic restrictive cardiomyopathy is supported only by the absence of specific pathology on either endomyocardial biopsies or at post-mortem. Restrictive cardiomyopathy is diagnosed based on medical history, physical examination, and tests: such as blood tests, electrocardiogram, chest X-ray, echocardiography, and magnetic resonance imaging. With its wide availability, echocardiography is probably the most important investigation to identify the left ventricular dysfunction and should be performed early and by groups that are familiar with the wide variety of aetiologies. Finally, on rare occasions, the differential diagnosis from constrictive pericarditis may be necessary.

  10. Interaction of chronic sleep restriction and circadian system in humans.

    PubMed

    Rogers, Naomi L; Dinges, David F

    2008-12-01

    Nocturnal sleep restriction and compensation with daytime naps is common in today's society. In a between-participants design, we examined the effects of chronic (10 nights) sleep restriction on 24 h plasma melatonin profiles in humans. Following a baseline period with 8.2 h time in bed (TIB) for sleep, participants were randomized to a control (8.2 h TIB) or sleep-restriction condition (4.2 h TIB), with and without diurnal naps. Sleep restriction was achieved via delaying bedtime and advancing wake time by 2 h each relative to the baseline sleep period. Participants were maintained in a controlled, time isolated laboratory environment throughout the protocol, with light levels below 40 lx at all times. Twenty-four hour plasma melatonin profiles were assessed at baseline and at the end of the sleep-restriction period, with subjects maintained in a constant posture protocol. Compared with the baseline assessment and the 8.2 h TIB control group, a significant phase delay in melatonin onset (1.2 +/- 0.9 h) occurred in all sleep-restriction (4.2 h TIB) groups (P < 0.05). There was no evidence of a phase advance or shortening of the period of melatonin secretion associated with the advanced waking time. These results suggest that nocturnal light and dark exposure may be more potent in effecting circadian phase shifts than exposure to morning light, at least in conditions of controlled, dim lighting in the laboratory.

  11. 90 Minutes on a Sunday Afternoon or: The Proof of the Special MT Issue Is in...

    ERIC Educational Resources Information Center

    Pinel, Adrian

    2002-01-01

    This article was written as a result of the author reading "MT177," a special issue dedicated to the teaching of "proof" in mathematics. He used the ideas in this special issue for planning his session "mathematical reasoning and proof," which was part of a weekend course for primary trainees. It consisted of three activities: (1) How many…

  12. 90 Minutes on a Sunday Afternoon or: The Proof of the Special MT Issue Is in...

    ERIC Educational Resources Information Center

    Pinel, Adrian

    2002-01-01

    This article was written as a result of the author reading "MT177," a special issue dedicated to the teaching of "proof" in mathematics. He used the ideas in this special issue for planning his session "mathematical reasoning and proof," which was part of a weekend course for primary trainees. It consisted of three activities: (1) How many…

  13. Plasticity of verbal fluency in older adults: a 90-minute telephone-based intervention.

    PubMed

    Sutter, Christine; Zöllig, Jacqueline; Martin, Mike

    2013-01-01

    There is evidence for specific age-related deficits in tasks of verbal fluency. The aim of the present study was to evaluate training and transfer effects after 3 weeks of telephone-based verbal fluency training in old age. Participants were assigned to one of three training groups, an active control group, or a no-contact control group. Training consisted of 15 sessions of 6 min each over a period of 3 weeks. For the training tasks, different versions of the verbal fluency task were used, each targeting a specific underlying cognitive process (i.e., processing speed, shifting, or inhibition). To measure transfer effects, a neuropsychological test battery including digit symbol substitution, trail making, go/no-go, digit span, n-back, and a verbal learning and memory test was administered before and after training. Our findings revealed training gains for initial letter fluency training and phonemic switching training, but not for excluded letter fluency training. Moreover, after initial letter fluency training and phonemic switching training, transfer to other verbal fluency tasks was found. In addition, phonemic switching training led to improvement in an untrained short-term memory task. The findings demonstrate that a telephone-based cognitive intervention of overall 90 min significantly improved cognitive performance in healthy older adults above and beyond the improvements in the active control group. The findings provide the basis for cognitive interventions that could easily be integrated into everyday lifestyles and are still targeting specific cognitive functions. Copyright © 2012 S. Karger AG, Basel.

  14. An experimental study of adolescent sleep restriction during a simulated school week: changes in phase, sleep staging, performance and sleepiness.

    PubMed

    Agostini, Alex; Carskadon, Mary A; Dorrian, Jillian; Coussens, Scott; Short, Michelle A

    2017-04-01

    This laboratory study investigated the impact of restricted sleep during a simulated school week on circadian phase, sleep stages and daytime functioning. Changes were examined across and within days and during a simulated weekend recovery. Participants were 12 healthy secondary school students (six male) aged 15-17 years [mean = 16.1 years, standard deviation (SD) = 0.9]. After 2 nights with 10 h (21:30-07:30 hours), time in bed was restricted to 5 h for 5 nights (02:30-07:30 hours), then returned to 10 h time in bed for 2 nights (21:30-07:30 hours). Saliva was collected in dim light on the first and last sleep restriction nights to measure melatonin onset phase. Sleep was recorded polysomnographically, and the Psychomotor Vigilance Task (PVT) and Karolinska Sleepiness Scale were undertaken 3-hourly while awake. Average phase delay measured by melatonin was 3 h (SD = 50 min). Compared to baseline, sleep during the restriction period contained a smaller percentage of Stages 1 and 2 and rapid eye movement (REM) and a greater percentage of Stage 4. PVT lapses increased significantly during sleep restriction and did not return to baseline levels during recovery. Subjective sleepiness showed a similar pattern during restriction, but returned to baseline levels during recovery. Results suggest that sustained attention in adolescents is affected negatively by sleep restriction, particularly in the early morning, and that a weekend of recovery sleep is insufficient to restore performance. The discrepancy between sleepiness ratings and performance may indicate a lack of perception of this residual impairment.

  15. Inter-Individual Differences in Neurobehavioural Impairment following Sleep Restriction Are Associated with Circadian Rhythm Phase.

    PubMed

    Sletten, Tracey L; Segal, Ahuva Y; Flynn-Evans, Erin E; Lockley, Steven W; Rajaratnam, Shantha M W

    2015-01-01

    Although sleep restriction is associated with decrements in daytime alertness and neurobehavioural performance, there are considerable inter-individual differences in the degree of impairment. This study examined the effects of short-term sleep restriction on neurobehavioural performance and sleepiness, and the associations between individual differences in impairments and circadian rhythm phase. Healthy adults (n = 43; 22 M) aged 22.5 ± 3.1 (mean ± SD) years maintained a regular 8:16 h sleep:wake routine for at least three weeks prior to laboratory admission. Sleep opportunity was restricted to 5 hours time-in-bed at home the night before admission and 3 hours time-in-bed in the laboratory, aligned by wake time. Hourly saliva samples were collected from 5.5 h before until 5 h after the pre-laboratory scheduled bedtime to assess dim light melatonin onset (DLMO) as a marker of circadian phase. Participants completed a 10-min auditory Psychomotor Vigilance Task (PVT), the Karolinska Sleepiness Scale (KSS) and had slow eye movements (SEM) measured by electrooculography two hours after waking. We observed substantial inter-individual variability in neurobehavioural performance, particularly in the number of PVT lapses. Increased PVT lapses (r = -0.468, p < 0.01), greater sleepiness (r = 0.510, p < 0.0001), and more slow eye movements (r = 0.375, p = 0.022) were significantly associated with later DLMO, consistent with participants waking at an earlier circadian phase. When the difference between DLMO and sleep onset was less than 2 hours, individuals were significantly more likely to have at least three attentional lapses the following morning. This study demonstrates that the phase of an individual's circadian system is an important variable in predicting the degree of neurobehavioural performance impairment in the hours after waking following sleep restriction, and confirms that other factors influencing performance decrements require further investigation.

  16. Inter-Individual Differences in Neurobehavioural Impairment following Sleep Restriction Are Associated with Circadian Rhythm Phase

    PubMed Central

    Sletten, Tracey L.; Segal, Ahuva Y.; Flynn-Evans, Erin E.; Lockley, Steven W.; Rajaratnam, Shantha M. W.

    2015-01-01

    Although sleep restriction is associated with decrements in daytime alertness and neurobehavioural performance, there are considerable inter-individual differences in the degree of impairment. This study examined the effects of short-term sleep restriction on neurobehavioural performance and sleepiness, and the associations between individual differences in impairments and circadian rhythm phase. Healthy adults (n = 43; 22 M) aged 22.5 ± 3.1 (mean ± SD) years maintained a regular 8:16 h sleep:wake routine for at least three weeks prior to laboratory admission. Sleep opportunity was restricted to 5 hours time-in-bed at home the night before admission and 3 hours time-in-bed in the laboratory, aligned by wake time. Hourly saliva samples were collected from 5.5 h before until 5 h after the pre-laboratory scheduled bedtime to assess dim light melatonin onset (DLMO) as a marker of circadian phase. Participants completed a 10-min auditory Psychomotor Vigilance Task (PVT), the Karolinska Sleepiness Scale (KSS) and had slow eye movements (SEM) measured by electrooculography two hours after waking. We observed substantial inter-individual variability in neurobehavioural performance, particularly in the number of PVT lapses. Increased PVT lapses (r = -0.468, p < 0.01), greater sleepiness (r = 0.510, p < 0.0001), and more slow eye movements (r = 0.375, p = 0.022) were significantly associated with later DLMO, consistent with participants waking at an earlier circadian phase. When the difference between DLMO and sleep onset was less than 2 hours, individuals were significantly more likely to have at least three attentional lapses the following morning. This study demonstrates that the phase of an individual’s circadian system is an important variable in predicting the degree of neurobehavioural performance impairment in the hours after waking following sleep restriction, and confirms that other factors influencing performance decrements require further investigation. PMID

  17. Biology of DNA restriction.

    PubMed Central

    Bickle, T A; Krüger, D H

    1993-01-01

    Our understanding of the evolution of DNA restriction and modification systems, the control of the expression of the structural genes for the enzymes, and the importance of DNA restriction in the cellular economy has advanced by leaps and bounds in recent years. This review documents these advances for the three major classes of classical restriction and modification systems, describes the discovery of a new class of restriction systems that specifically cut DNA carrying the modification signature of foreign cells, and deals with the mechanisms developed by phages to avoid the restriction systems of their hosts. PMID:8336674

  18. Genetics of restrictive cardiomyopathy.

    PubMed

    Sen-Chowdhry, Srijita; Syrris, Petros; McKenna, William J

    2010-04-01

    Restrictive physiology, a severe form of diastolic dysfunction, is characteristically observed in the setting of constrictive pericarditis and myocardial restriction. The latter is commonly due to systemic diseases, some of which are inherited as mendelian traits (eg, hereditary amyloidosis), while others are multifactorial (eg, sarcoidosis). When restrictive physiology occurs as an early and dominant feature of a primary myocardial disorder, it may be termed restrictive cardiomyopathy. In the past decade, clinical and genetic studies have demonstrated that restrictive cardiomyopathy as such is part of the spectrum of sarcomeric disease and frequently coexists with hypertrophic cardiomyopathy in affected families.

  19. Towards standardisation and improved understanding of sleep restriction therapy for insomnia disorder: A systematic examination of CBT-I trial content.

    PubMed

    Kyle, Simon D; Aquino, Maria Raisa Jessica; Miller, Christopher B; Henry, Alasdair L; Crawford, Megan R; Espie, Colin A; Spielman, Arthur J

    2015-10-01

    Sleep restriction therapy is a core element of contemporary cognitive-behavioural therapy for insomnia and is also effective as a single-component therapeutic strategy. Since its original description, sleep restriction therapy has been applied in several different ways, potentially limiting understanding of key therapeutic ingredients, mode of action, evidence synthesis, and clinical implementation. We sought to examine the quality of reporting and variability in the application of sleep restriction therapy within the context of insomnia intervention trials. Systematic literature searches revealed 88 trials of cognitive-behavioural therapy/sleep restriction therapy that met pre-defined inclusion/exclusion criteria. All papers were coded in relation to their description of sleep restriction therapy procedures. Findings indicate that a large proportion of papers (39%) do not report any details regarding sleep restriction therapy parameters and, for those papers that do, variability in implementation is present at every level (sleep window generation, minimum time-in-bed, sleep efficiency titration criteria, and positioning of sleep window). Only 7% of papers reported all parameters of sleep restriction treatment. Poor reporting and variability in the application of sleep restriction therapy may hinder progress in relation to evidence synthesis, specification of mechanistic components, and refinement of therapeutic procedures for patient benefit. We set out guidelines for the reporting of sleep restriction therapy as well as a research agenda aimed at advancing understanding of sleep restriction therapy.

  20. Subchronic sleep restriction causes tissue-specific insulin resistance.

    PubMed

    Rao, Madhu N; Neylan, Thomas C; Grunfeld, Carl; Mulligan, Kathleen; Schambelan, Morris; Schwarz, Jean-Marc

    2015-04-01

    Short sleep duration is associated with an increased risk of type 2 diabetes. Subchronic sleep restriction (SR) causes insulin resistance, but the mechanisms and roles of specific tissues are unclear. The purpose of this article was to determine whether subchronic SR altered (1) hepatic insulin sensitivity, (2) peripheral insulin sensitivity, and (3) substrate utilization. This was a randomized crossover study in which 14 subjects underwent 2 admissions separated by a washout period. Each admission had 2 acclimatization nights followed by 5 nights of either SR (4 hours time in bed) or normal sleep (8 hours time in bed). MAIN OUTCOME MEASURE/METHODS: Insulin sensitivity (measured by hyperinsulinemic-euglycemic clamp) and hepatic insulin sensitivity (measured by stable isotope techniques) were measured. In addition, we assayed stress hormone (24-hour urine free cortisol, metanephrine, and normetanephrine), nonesterified fatty acid (NEFA), and β-hydroxybutyrate (β-OH butyrate) levels. Resting energy expenditure (REE) and respiratory quotient (RQ) were measured by indirect calorimetry. Compared to normal sleep, whole-body insulin sensitivity decreased by 25% (P = .008) with SR and peripheral insulin sensitivity decreased by 29% (P = .003). Whereas hepatic insulin sensitivity (endogenous glucose production) did not change significantly, percent gluconeogenesis increased (P = .03). Stress hormones increased modestly (cortisol by 21%, P = .04; metanephrine by 8%, P = .014; normetanephrine by 18%, P = .002). Fasting NEFA and β-OH butyrate levels increased substantially (62% and 55%, respectively). REE did not change (P = 0.98), but RQ decreased (0.81 ± .02 vs 0.75 ± 0.02, P = .045). Subchronic SR causes unique metabolic disturbances characterized by peripheral, but not hepatic, insulin resistance; this was associated with a robust increase in fasting NEFA levels (indicative of increased lipolysis), decreased RQ, and increased β-OH butyrate levels (indicative of whole

  1. Achieving sustainable first door-to-balloon times of 90 minutes for regional transfer ST-segment elevation myocardial infarction.

    PubMed

    Wilson, B Hadley; Humphrey, Angela D; Cedarholm, John C; Downey, William E; Haber, Robert H; Kowalchuk, Glen J; Rinaldi, Michael J; Miller, Denise A; Sarafin, Jennifer L; Garvey, J Lee

    2013-10-01

    A network approach to transfer ST-segment elevation myocardial infarction (STEMI) patients can achieve durable first door-to-balloon times (1st D2B) for percutaneous coronary intervention (PCI) within 90 min. Nationally, a minority of STEMI patients from referral centers obtain 1st D2B in <2 h and even fewer in <90 min. Included were transfer STEMI patients from 9 network hospitals treated in 2007 compared with 2008 to 2011 after installing the following initiatives: 1) established hospital referral system; 2) goal-oriented performance protocols; 3) expedited transport by ground or air; 4) first hospital activation of the PCI hospital catheterization laboratory; and 5) outreach coordinator and patient-level web-based feedback to the referring hospital. A total of 101 STEMI patients transported in 2007 were compared with 442 STEMI patients transferred after starting these initiatives for STEMI from 2008 to 2011, with the median door-in to door-out time decreased from 44 to 35 min (p < 0.0001), the median 1st D2B decreasing from 109.5 to 88.0 min (p < 0.0001), and the percentage under 90 min increased from 22.8% to 55.9% (p < 0.0001). Overall, throughout the study period (2007 to 2011), the transport times remained consistent (median 36.5 vs. 36.0 min, p = 0.98), whereas the PCI hospital D2B decreased from 20.0 to 16.0 min (p < 0.0001). Length of stay and in-hospital mortality remained low at 3.0 days and under 4%, respectively. A system-wide network program can achieve sustained (over 4 years) 1st D2B times of <90 min. Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

  2. Banking sleep: realization of benefits during subsequent sleep restriction and recovery.

    PubMed

    Rupp, Tracy L; Wesensten, Nancy J; Bliese, Paul D; Balkin, Thomas J

    2009-03-01

    Determine whether sleep extension (a) improves alertness and performance during subsequent sleep restriction and (b) impacts the rate at which alertness and performance are restored by post-restriction recovery sleep. Participants were randomly assigned to an Extended (10 h time in bed [TIB]) or Habitual TIB [mean (SD) hours = 7.09 (0.7)] sleep group for one week, followed by 1 Baseline (10 hours or habitual TIB), 7 Sleep Restriction (3 h TIB), and 5 Recovery Sleep nights (8 h TIB). Performance and alertness tests were administered hourly between 08:00-18:00 during all in-laboratory phases of the study. Residential sleep/performance testing facility. Twenty-four healthy adults (ages 18-39) participated in the study. Extended vs. habitual sleep durations prior to sleep restriction. Psychomotor vigilance task (PVT) lapses were more frequent and modified maintenance of wakefulness (MWT) sleep latency was shorter in the Habitual group than in the Extended group across the sleep restriction phase. During the Recovery phase, PVT speed rebounded faster (and PVT lapsing recovered significantly after the first night of recovery sleep) in the Extended group. No group differences in subjective sleepiness were evident during any phase of the study. The extent to which sleep restriction impairs objectively measured alertness and performance, and the rate at which these impairments are subsequently reversed by recovery sleep, varies as a function of the amount of nightly sleep obtained prior to the sleep restriction period. This suggests that the physiological mechanism(s) underlying chronic sleep debt undergo long-term (days/weeks) accommodative/adaptive changes.

  3. Sleep restriction decreases the physical activity of adults at risk for type 2 diabetes.

    PubMed

    Bromley, Lindsay E; Booth, John N; Kilkus, Jennifer M; Imperial, Jacqueline G; Penev, Plamen D

    2012-07-01

    To test the hypothesis that recurrent sleep curtailment will result in decreased physical activity in adults at risk for type 2 diabetes. Two-condition 2-period randomized crossover study. University General Clinical Research Center. Eighteen healthy patients with parental history of type 2 diabetes (9 females and 9 males, age 27 yr [standard deviation 3], body mass index 23.7 [2.3] kg/m²). Two week-long inpatient sessions with 8.5 or 5.5-hr nighttime sleep opportunity. Participants who exercised regularly (39%) could follow their usual exercise routines during both sessions. Sleep and total body movement were measured by wrist actigraphy and waist accelerometry. Subjective mood and vigor was assessed using visual analog scales. The main outcome was the comparison of total activity counts between sleep conditions. Ancillary endpoints included changes in sedentary, light, and moderate plus vigorous activity, and their association with changes in mood and vigor. Daily sleep was reduced by 2.3 hr (P < 0.001) and total activity counts were 31% lower (P = 0.020) during the 5.5-hr time-in-bed condition. This was accompanied by a 24% reduction in moderate-plus-vigorous activity time (P = 0.005) and more sedentary behavior (+21 min/day; P = 0.020). The decrease in daily activity during the 5.5-hr time-in-bed condition was seen mostly in participants who exercised regularly (-39 versus -4% in exercisers versus nonexercisers; P = 0.027). Sleep loss-related declines in physical activity correlated strongly with declines in subjective vigor (R = 0.90; P < 0.001). Experimental sleep restriction results in decreased amount and intensity of physical activity in adults at risk for type 2 diabetes.

  4. Physiological arousal and attention during a week of continuous sleep restriction.

    PubMed

    Cote, Kimberly A; Milner, Catherine E; Osip, Stephanie L; Baker, Meghan L; Cuthbert, Brielle P

    2008-10-20

    Waking brain physiology underlying deficits from continuous sleep restriction (CSR) is not well understood. Fourteen good sleepers participated in a 21-day protocol where they slept their usual amount in a baseline week, had their time in bed restricted by 33% in a CSR week, and slept the desired amount in a recovery week. Participants slept at home, completing diaries and wearing activity monitors to verify compliance. Each day participants completed an RT task and mood and sleepiness ratings every 3 h. Laboratory assessment of electrophysiology and performance took place at the end of baseline, three times throughout the CSR week, and at the beginning of recovery. Participants reported less sleep during CSR which was confirmed by activity monitors. Correspondingly, well-being and neurobehavioural performance was impaired. Quantitative EEG analysis revealed significantly reduced arousal between the 1st and 7th days of restriction and linear effects at anterior sites (Fp2, Fz, F8, T8). At posterior sites (P4, P8), reductions occurred only later in the week between the 4th and 7th nights of restriction. Both the immediate linear decline in arousal and precipitous drop later in the week were apparent at central sites (C4, Cz). Thus, frontal regions were affected immediately, while parietal regions showed maintenance of function until restriction was more severe. The P300 ERP component showed evidence of reduced attention by the 7th day of restriction (at Pz, P4). EEG and ERPs deficits were more robust in the right-hemisphere, which may reflect greater vulnerability to sleep loss in the non-dominant hemisphere.

  5. Energy restriction and potential energy restriction mimetics.

    PubMed

    Nikolai, Sibylle; Pallauf, Kathrin; Huebbe, Patricia; Rimbach, Gerald

    2015-12-01

    Energy restriction (ER; also known as caloric restriction) is the only nutritional intervention that has repeatedly been shown to increase lifespan in model organisms and may delay ageing in humans. In the present review we discuss current scientific literature on ER and its molecular, metabolic and hormonal effects. Moreover, criteria for the classification of substances that might induce positive ER-like changes without having to reduce energy intake are summarised. Additionally, the putative ER mimetics (ERM) 2-deoxy-d-glucose, metformin, rapamycin, resveratrol, spermidine and lipoic acid and their suggested molecular targets are discussed. While there are reports on these ERM candidates that describe lifespan extension in model organisms, data on longevity-inducing effects in higher organisms such as mice remain controversial or are missing. Furthermore, some of these candidates produce detrimental side effects such as immunosuppression or lactic acidosis, or have not been tested for safety in long-term studies. Up to now, there are no known ERM that could be recommended without limitations for use in humans.

  6. Rotating restricted Schur polynomials

    NASA Astrophysics Data System (ADS)

    Bornman, Nicholas; de Mello Koch, Robert; Tribelhorn, Laila

    2017-09-01

    Large N but nonplanar limits of 𝒩 = 4 super-Yang-Mills theory can be described using restricted Schur polynomials. Previous investigations demonstrate that the action of the one loop dilatation operator on restricted Schur operators, with classical dimension of order N and belonging to the su(2) sector, is largely determined by the su(2) ℛ symmetry algebra as well as structural features of perturbative field theory. Studies presented so far have used the form of ℛ symmetry generators when acting on small perturbations of half-BPS operators. In this paper as a first step towards going beyond small perturbations of the half-BPS operators, we explain how the exact action of symmetry generators on restricted Schur polynomials can be determined.

  7. Perioperative Fluid Restriction

    PubMed Central

    Bleier, Joshua I.S.; Aarons, Cary B.

    2013-01-01

    Perioperative fluid management of the colorectal surgical patient has evolved significantly over the last five decades. Older notions espousing aggressive hydration have been shown to be associated with increased complications. Newer data regarding fluid restriction has shown an association with improved outcomes. Management of perioperative fluid administration can be considered in three primary phases: In the preoperative phase, data suggests that avoidance of preoperative bowel preparation and avoidance of undue preoperative dehydration can improve outcomes. Although the type of intraoperative fluid given does not have a significant effect on outcome, data do suggest that a restrictive fluid regimen results in improved outcomes. Finally, in the postoperative phase of fluid management, a fluid-restrictive regimen, coupled with early enteral feeding also seems to result in improved outcomes. PMID:24436675

  8. Calorie restriction and stroke

    PubMed Central

    2011-01-01

    Stroke, a major cause of disability and mortality in the elderly, occurs when a cerebral blood vessel is occluded or ruptured, resulting in ischemic damage and death of brain cells. The injury mechanism involves metabolic and oxidative stress, excitotoxicity, apoptosis and inflammatory processes, including activation of glial cells and infiltration of leukocytes. In animal models, dietary energy restriction, by daily calorie reduction (CR) or intermittent fasting (IF), extends lifespan and decreases the development of age-related diseases. Dietary energy restriction may also benefit neurons, as suggested by experimental evidence showing that CR and IF protect neurons against degeneration in animal models. Recent findings by our group and others suggest the possibility that dietary energy restriction may protect against stroke induced brain injury, in part by inducing the expression of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF) and basic fibroblast growth factor (bFGF); protein chaperones, including heat shock protein 70 (Hsp70) and glucose regulated protein 78 (GRP78); antioxidant enzymes, such as superoxide dismutases (SOD) and heme oxygenase-1 (HO-1), silent information regulator T1 (SIRT1), uncoupling proteins and anti-inflammatory cytokines. This article discusses the protective mechanisms activated by dietary energy restriction in ischemic stroke. PMID:21910904

  9. Restricting Grammatical Complexity

    ERIC Educational Resources Information Center

    Frank, Robert

    2004-01-01

    Theories of natural language syntax often characterize grammatical knowledge as a form of abstract computation. This paper argues that such a characterization is correct, and that fundamental properties of grammar can and should be understood in terms of restrictions on the complexity of possible grammatical computation, when defined in terms of…

  10. Effects of Experimental Sleep Restriction on Weight Gain, Caloric Intake, and Meal Timing in Healthy Adults

    PubMed Central

    Spaeth, Andrea M.; Dinges, David F.; Goel, Namni

    2013-01-01

    Study Objectives: Examine sleep restriction's effects on weight gain, daily caloric intake, and meal timing. Design: Repeated-measures experiments assessing body weight at admittance and discharge in all subjects (N = 225) and caloric intake and meal timing across days following 2 baseline nights, 5 sleep restriction nights and 2 recovery nights or across days following control condition nights in a subset of subjects (n = 37). Setting: Controlled laboratory environment. Participants: Two hundred twenty-five healthy adults aged 22-50 y (n = 198 sleep-restricted subjects; n = 31 with caloric intake data; n = 27 control subjects; n = 6 with caloric intake data). Interventions: Approximately 8-to-1 randomization to an experimental condition (including five consecutive nights of 4 h time in bed [TIB]/night, 04:00-08:00) or to a control condition (all nights 10 h TIB/night, 22:00-08:00). Measurements and Results: Sleep-restricted subjects gained more weight (0.97 ± 1.4 kg) than control subjects (0.11 ± 1.9 kg; d = 0.51, P = 0.007). Among sleep-restricted subjects, African Americans gained more weight than Caucasians (d = 0.37, P = 0.003) and males gained more weight than females (d = 0.38, P = 0.004). Sleep-restricted subjects consumed extra calories (130.0 ± 43.0% of daily caloric requirement) during days with a delayed bedtime (04:00) compared with control subjects who did not consume extra calories (100.6 ± 11.4%; d = 0.94, P = 0.003) during corresponding days. In sleep-restricted subjects, increased daily caloric intake was due to more meals and the consumption of 552.9 ± 265.8 additional calories between 22:00-03:59. The percentage of calories derived from fat was greater during late-night hours (22:00-03:59, 33.0 ± 0.08%) compared to daytime (08:00-14:59, 28.2 ± 0.05%) and evening hours (15:00-21:59, 29.4 ± 0.06%; Ps < 0.05). Conclusions: In the largest, most diverse healthy sample studied to date under controlled laboratory conditions, sleep restriction

  11. Frequencies of restriction sites.

    PubMed Central

    Waterman, M S

    1983-01-01

    Restriction sites or other sequence patterns are usually assumed to occur according to a Poisson distribution with mean equal to the reciprocal of the probability of the given site or pattern. For situations where non-overlapping occurrences of patterns, such as restriction sites, are the objects of interest, this note shows that the Poisson assumption is frequently misleading. Both the case of base composition (independent bases) and of dinucleotide frequencies (Markov chains) are treated. Moreover, a new technique is presented which allows treatment of collections of patterns, where the departure from the Poisson assumption is even more striking. This later case includes double digests, and an example of a five enzyme digest is included. PMID:6324109

  12. Chronic Moderate Sleep Restriction in Older Long Sleepers and Older Average Duration Sleepers: A Randomized Controlled Trial

    PubMed Central

    Youngstedt, Shawn D.; Jean-Louis, Girardin; Bootzin, Richard R.; Kripke, Daniel F.; Cooper, Jonnifer; Dean, Lauren R.; Catao, Fabio; James, Shelli; Vining, Caitlyn; Williams, Natasha J.; Irwin, Michael R.

    2013-01-01

    Epidemiologic studies have consistently shown that sleeping < 7 hr and ≥ 8 hr is associated with increased mortality and morbidity. The risks of short sleep may be consistent with results from experimental sleep deprivation studies. However, there has been little study of chronic moderate sleep restriction and no evaluation of older adults who might be more vulnerable to negative effects of sleep restriction, given their age-related morbidities. Moreover, the risks of long sleep have scarcely been examined experimentally. Moderate sleep restriction might benefit older long sleepers who often spend excessive time in bed (TIB), in contrast to older adults with average sleep patterns. Our aims are: (1) to examine the ability of older long sleepers and older average sleepers to adhere to 60 min TIB restriction; and (2) to contrast effects of chronic TIB restriction in older long vs. average sleepers. Older adults (n=100) (60–80 yr) who sleep 8–9 hr per night and 100 older adults who sleep 6–7.25 hr per night will be examined at 4 sites over 5 years. Following a 2-week baseline, participants will be randomized to one of two 12-week treatments: (1) a sleep restriction involving a fixed sleep-wake schedule, in which TIB is reduced 60 min below each participant’s baseline TIB; (2) a control treatment involving no sleep restriction, but a fixed sleep schedule. Sleep will be assessed with actigraphy and a diary. Measures will include glucose tolerance, sleepiness, depressive symptoms, quality of life, cognitive performance, incidence of illness or accident, and inflammation. PMID:23811325

  13. Chronic moderate sleep restriction in older long sleepers and older average duration sleepers: a randomized controlled trial.

    PubMed

    Youngstedt, Shawn D; Jean-Louis, Girardin; Bootzin, Richard R; Kripke, Daniel F; Cooper, Jonnifer; Dean, Lauren R; Catao, Fabio; James, Shelli; Vining, Caitlin; Williams, Natasha J; Irwin, Michael R

    2013-09-01

    Epidemiologic studies have consistently shown that sleeping <7 h and ≥8 h is associated with increased mortality and morbidity. The risks of short sleep may be consistent with results from experimental sleep deprivation studies. However, there has been little study of chronic moderate sleep restriction and little evaluation of older adults who might be more vulnerable to negative effects of sleep restriction, given their age-related morbidities. Moreover, the risks of long sleep have scarcely been examined experimentally. Moderate sleep restriction might benefit older long sleepers who often spend excessive time in bed (TIB) in contrast to older adults with average sleep patterns. Our aims are: (1) to examine the ability of older long sleepers and older average sleepers to adhere to 60 min TIB restriction; and (2) to contrast effects of chronic TIB restriction in older long vs. average sleepers. Older adults (n = 100) (60-80 years) who sleep 8-9 h per night and 100 older adults who sleep 6-7.25 h per night will be examined at 4 sites over 5 years. Following a 2-week baseline, participants will be randomized to one of two 12-week treatments: (1) a sleep restriction involving a fixed sleep-wake schedule, in which TIB is reduced 60 min below each participant's baseline TIB; and (2) a control treatment involving no sleep restriction, but a fixed sleep schedule. Sleep will be assessed with actigraphy and a diary. Measures will include glucose tolerance, sleepiness, depressive symptoms, quality of life, cognitive performance, incidence of illness or accident, and inflammation.

  14. License restrictions at Barnwell

    SciTech Connect

    Autry, V.R.

    1991-12-31

    The State of South Carolina was delegated the authority by the US Nuclear Regulatory Commission to regulate the receipt, possession, use and disposal of radioactive material as an Agreement State. Since 1970, the state has been the principal regulatory authority for the Barnwell Low-Level Waste Disposal Facility operated by Chem-Nuclear Systems, Inc. The radioactive material license issued authorizing the receipt and disposal of low-level waste contains numerous restrictions to ensure environmental protection and compliance with shallow land disposal performance criteria. Low-level waste has evolved from minimally contaminated items to complex waste streams containing high concentrations of radionuclides and processing chemicals which necessitated these restrictions. Additionally, some waste with their specific radionuclides and concentration levels, many classified as low-level radioactive waste, are not appropriate for shallow land disposal unless additional precautions are taken. This paper will represent a number of these restrictions, the rationale for them, and how they are being dealt with at the Barnwell disposal facility.

  15. PER3 and ADORA2A polymorphisms impact neurobehavioral performance during sleep restriction.

    PubMed

    Rupp, Tracy L; Wesensten, Nancy J; Newman, Rachel; Balkin, Thomas J

    2013-04-01

    The objective of the study was to determine whether ADORA2A or PER3 polymorphisms contribute to individual responsivity to sleep restriction. Nineteen healthy adults (ages 18-39, 11 males, 8 females) underwent sleep restriction (SR) which consisted of seven nights of 3 h time in bed (TIB) (04:00-07:00). SR was preceded by seven in-laboratory nights of 10 h TIB (21:00-07:00) and followed by three nights of 8 h TIB (23:00-07:00). Volunteers underwent psychomotor vigilance, objective alertness, and subjective sleepiness assessments throughout. Volunteers were genotyped for the PER3 VNTR polymorphism (PER3(4/4) n = 7; PER3(4/5) n = 10; PER3(5/5) n = 2) and the ADORA2A c.1083T>C polymorphism, (ADORA2A(C) (/T) n = 9; ADORA2A(T) (/T) n = 9; ADORA2A(C) (/C) n = 1) using polymerase chain reaction (PCR). Separate mixed-model anovas were used to assess contributions of ADORA2A and PER3 polymorphisms. Results showed that PER3(4/4) and ADORA2A(C/T) individuals expressed greater behavioral resiliency to SR compared to PER(4/5) and ADORA2A(T/T) individuals. Our findings contrast with previously reported non-significant effects for the PER3 polymorphism under a less challenging sleep restriction regimen (4 h TIB per night for five nights). We conclude that PER3 and ADORA2A polymorphisms become more behaviorally salient with increasing severity and/or duration of sleep restriction (based on psychomotor vigilance). Given the small sample size these results are preliminary and require replication.

  16. Acute sleep restriction effects on emotion responses in 30- to 36-month-old children.

    PubMed

    Berger, Rebecca H; Miller, Alison L; Seifer, Ronald; Cares, Stephanie R; LeBourgeois, Monique K

    2012-06-01

    Early childhood is a period of dramatic change in sleep and emotion processing, as well as a time when disturbance in both domains are first detected. Although sleep is recognized as central in emotion processing and psychopathology, the great majority of experimental data have been collected in adults. We examined the effects of acute sleep restriction (nap deprivation) on toddlers' emotion expression. Ten healthy children (seven females; 30-36 months old) followed a strict sleep schedule (≥12.5 h time in bed per 24-h) for 5 days, before each of two randomly assigned afternoon emotion assessments following Nap and No-Nap conditions (resulting in an 11-day protocol). Children viewed emotion-eliciting pictures (five positive, three neutral, three negative) and completed puzzles (one solvable, one unsolvable). Children's faces were video-recorded, and emotion displays were coded. When sleep restricted, children displayed less confusion in response to neutral pictures, more negativity to neutral and negative pictures, and less positivity to positive pictures. Sleep restriction also resulted in a 34% reduction in positive emotion responses (solvable puzzle), as well as a 31% increase in negative emotion responses and a 39% decrease in confused responses (unsolvable puzzle). These findings suggest sleep is a key factor in how young children respond to their world. When sleep restricted, toddlers are neither able to take full advantage of positive experiences nor are they as adaptive in challenging contexts. If insufficient sleep consistently 'taxes' young children's emotion responses, they may not manage emotion regulation challenges effectively, potentially placing them at risk for future emotional/behavioral problems.

  17. Acute Sleep Restriction Effects on Emotion Responses in 30- to 36-Month-Old Children

    PubMed Central

    Berger, Rebecca H.; Miller, Alison L.; Seifer, Ronald; Cares, Stephanie R.; LeBourgeois, Monique K.

    2011-01-01

    SUMMARY Early childhood is a period of dramatic change in sleep and emotion processing, as well as a time when disturbance in both domains are first detected. Although sleep is recognized as central in emotion processing and psychopathology, the great majority of experimental data have been collected in adults. We examined the effects of acute sleep restriction (nap deprivation) on toddlers’ emotion expression. Ten healthy children (7 females; 30–36 months) followed a strict sleep schedule (≥12.5 hrs time in bed/24 hrs) for 5 days before each of two randomly-assigned afternoon emotion assessments following Nap and No-Nap conditions (resulting in an 11-day protocol). Children viewed emotion-eliciting pictures (5 positive, 3 neutral, 3 negative) and completed puzzles (1 solvable, 1 unsolvable). Children’s faces were video-recorded, and emotion displays were coded. When sleep restricted, children displayed less confusion in response to neutral pictures, more negativity to neutral and negative pictures, and less positivity to positive pictures. Sleep restriction also resulted in a 34% reduction in positive emotion responses (solvable puzzle), as well as a 31% increase in negative emotion responses and a 39% decrease in confused responses (unsolvable puzzle). These findings suggest sleep is a key factor in how young children respond to their world. When sleep restricted, toddlers are neither able to take full advantage of positive experiences nor are they as adaptive in challenging contexts. If insufficient sleep consistently “taxes” young children’s emotion responses, they may not manage emotion regulation challenges effectively, potentially placing them at risk for future emotional/behavioral problems. PMID:21988087

  18. Sleep Restriction Decreases the Physical Activity of Adults at Risk for Type 2 Diabetes

    PubMed Central

    Bromley, Lindsay E.; Booth, John N.; Kilkus, Jennifer M.; Imperial, Jacqueline G.; Penev, Plamen D.

    2012-01-01

    Study Objective: To test the hypothesis that recurrent sleep curtailment will result in decreased physical activity in adults at risk for type 2 diabetes. Design: Two-condition 2-period randomized crossover study. Setting: University General Clinical Research Center. Participants: Eighteen healthy patients with parental history of type 2 diabetes (9 females and 9 males, age 27 yr [standard deviation 3], body mass index 23.7 [2.3] kg/m2). Interventions: Two week-long inpatient sessions with 8.5 or 5.5-hr nighttime sleep opportunity. Participants who exercised regularly (39%) could follow their usual exercise routines during both sessions. Measurements and Results: Sleep and total body movement were measured by wrist actigraphy and waist accelerometry. Subjective mood and vigor was assessed using visual analog scales. The main outcome was the comparison of total activity counts between sleep conditions. Ancillary endpoints included changes in sedentary, light, and moderate plus vigorous activity, and their association with changes in mood and vigor. Daily sleep was reduced by 2.3 hr (P < 0.001) and total activity counts were 31% lower (P = 0.020) during the 5.5-hr time-in-bed condition. This was accompanied by a 24% reduction in moderate-plus-vigorous activity time (P = 0.005) and more sedentary behavior (+21 min/day; P = 0.020). The decrease in daily activity during the 5.5-hr time-in-bed condition was seen mostly in participants who exercised regularly (-39 versus −4% in exercisers versus nonexercisers; P = 0.027). Sleep loss-related declines in physical activity correlated strongly with declines in subjective vigor (R = 0.90; P < 0.001). Conclusions: Experimental sleep restriction results in decreased amount and intensity of physical activity in adults at risk for type 2 diabetes. Citation: Bromley LE; Booth JN; Kilkus JM; Imperial JG; Penev PD. Sleep restriction decreases the physical activity of adults at risk for type 2 diabetes. SLEEP 2012

  19. Phenotypic Stability of Energy Balance Responses to Experimental Total Sleep Deprivation and Sleep Restriction in Healthy Adults

    PubMed Central

    Dennis, Laura E.; Spaeth, Andrea M.; Goel, Namni

    2016-01-01

    Experimental studies have shown that sleep restriction (SR) and total sleep deprivation (TSD) produce increased caloric intake, greater fat consumption, and increased late-night eating. However, whether individuals show similar energy intake responses to both SR and TSD remains unknown. A total of N = 66 healthy adults (aged 21–50 years, 48.5% women, 72.7% African American) participated in a within-subjects laboratory protocol to compare daily and late-night intake between one night of SR (4 h time in bed, 04:00–08:00) and one night of TSD (0 h time in bed) conditions. We also examined intake responses during subsequent recovery from SR or TSD and investigated gender differences. Caloric and macronutrient intake during the day following SR and TSD were moderately to substantially consistent within individuals (Intraclass Correlation Coefficients: 0.34–0.75). During the late-night period of SR (22:00–04:00) and TSD (22:00–06:00), such consistency was slight to moderate, and participants consumed a greater percentage of calories from protein (p = 0.01) and saturated fat (p = 0.02) during SR, despite comparable caloric intake (p = 0.12). Similarly, participants consumed a greater percentage of calories from saturated fat during the day following SR than TSD (p = 0.03). Participants also consumed a greater percentage of calories from protein during recovery after TSD (p < 0.001). Caloric intake was greater in men during late-night hours and the day following sleep loss. This is the first evidence of phenotypic trait-like stability and differential vulnerability of energy balance responses to two commonly experienced types of sleep loss: our findings open the door for biomarker discovery and countermeasure development to predict and mitigate this critical health-related vulnerability. PMID:27999367

  20. Phenotypic Stability of Energy Balance Responses to Experimental Total Sleep Deprivation and Sleep Restriction in Healthy Adults.

    PubMed

    Dennis, Laura E; Spaeth, Andrea M; Goel, Namni

    2016-12-19

    Experimental studies have shown that sleep restriction (SR) and total sleep deprivation (TSD) produce increased caloric intake, greater fat consumption, and increased late-night eating. However, whether individuals show similar energy intake responses to both SR and TSD remains unknown. A total of N = 66 healthy adults (aged 21-50 years, 48.5% women, 72.7% African American) participated in a within-subjects laboratory protocol to compare daily and late-night intake between one night of SR (4 h time in bed, 04:00-08:00) and one night of TSD (0 h time in bed) conditions. We also examined intake responses during subsequent recovery from SR or TSD and investigated gender differences. Caloric and macronutrient intake during the day following SR and TSD were moderately to substantially consistent within individuals (Intraclass Correlation Coefficients: 0.34-0.75). During the late-night period of SR (22:00-04:00) and TSD (22:00-06:00), such consistency was slight to moderate, and participants consumed a greater percentage of calories from protein (p = 0.01) and saturated fat (p = 0.02) during SR, despite comparable caloric intake (p = 0.12). Similarly, participants consumed a greater percentage of calories from saturated fat during the day following SR than TSD (p = 0.03). Participants also consumed a greater percentage of calories from protein during recovery after TSD (p < 0.001). Caloric intake was greater in men during late-night hours and the day following sleep loss. This is the first evidence of phenotypic trait-like stability and differential vulnerability of energy balance responses to two commonly experienced types of sleep loss: our findings open the door for biomarker discovery and countermeasure development to predict and mitigate this critical health-related vulnerability.

  1. Optimizing sleep/wake schedules in space: Sleep during chronic nocturnal sleep restriction with and without diurnal naps

    NASA Astrophysics Data System (ADS)

    Mollicone, Daniel J.; Van Dongen, Hans P. A.; Dinges, David F.

    2007-02-01

    Effective sleep/wake schedules for space operations must balance severe time constraints with allocating sufficient time for sleep in order to sustain high levels of neurobehavioral performance. Developing such schedules requires knowledge about the relationship between scheduled "time in bed" (TIB) and actual physiological sleep obtained. A ground-based laboratory study in N=93 healthy adult subjects was conducted to investigate physiological sleep obtained in a range of restricted sleep schedules. Eighteen different conditions with restricted nocturnal anchor sleep, with and without diurnal naps, were examined in a response surface mapping paradigm. Sleep efficiency was found to be a function of total TIB per 24 h regardless of how the sleep was divided among nocturnal anchor sleep and diurnal nap sleep periods. The amounts of sleep stages 1+2 and REM showed more complex relationships with the durations of the anchor and nap sleep periods, while slow-wave sleep was essentially preserved among the different conditions of the experiment. The results of the study indicated that when sleep was chronically restricted, sleep duration was largely unaffected by whether the sleep was placed nocturnally or split between nocturnal anchor sleep periods and daytime naps. Having thus assessed that split-sleep schedules are feasible in terms of obtaining physiological sleep, further research will reveal whether these schedules and the associated variations in the distribution of sleep stages may be advantageous in mitigating neurobehavioral performance impairment in the face of limited time for sleep.

  2. APOBECs and Virus Restriction

    PubMed Central

    Harris, Reuben S.; Dudley, Jaquelin P.

    2015-01-01

    The APOBEC family of single-stranded DNA cytosine deaminases comprises a formidable arm of the vertebrate innate immune system. Pre-vertebrates express a single APOBEC, whereas some mammals produce as many as eleven enzymes. The APOBEC3 subfamily displays both copy number variation and polymorphisms, consistent with ongoing pathogenic pressures. These enzymes restrict the replication of many DNA-based parasites, such as exogenous viruses and endogenous transposable elements. APOBEC1 and activation-induced cytosine deaminase (AID) have specialized functions in RNA editing and antibody gene diversification, respectively, whereas APOBEC2 and APOBEC4 appear to have different functions. Nevertheless, the APOBEC family protects against both periodic viral zoonoses as well as exogenous and endogenous parasite replication. This review highlights viral pathogens that are restricted by APOBEC enzymes, but manage to escape through unique mechanisms. The sensitivity of viruses that lack counterdefense measures highlights the need to develop APOBEC-enabling small molecules as a new class of anti-viral drugs. PMID:25818029

  3. EEG Changes across Multiple Nights of Sleep Restriction and Recovery in Adolescents: The Need for Sleep Study

    PubMed Central

    Ong, Ju Lynn; Lo, June C.; Gooley, Joshua J.; Chee, Michael W.L.

    2016-01-01

    Study Objectives: To investigate sleep EEG changes in adolescents across 7 nights of sleep restriction to 5 h time in bed [TIB]) and 3 recovery nights of 9 h TIB. Methods: A parallel-group design, quasi-laboratory study was conducted in a boarding school. Fifty-five healthy adolescents (25 males, age = 15–19 y) who reported habitual TIBs of approximately 6 h on week nights (group average) but extended their sleep on weekends were randomly assigned to Sleep Restriction (SR) or Control groups. Participants underwent a 2-week protocol comprising 3 baseline nights (TIB = 9 h), 7 nights of sleep opportunity manipulation (TIB = 5 h for the SR and 9 h for the Control group), and 3 nights of recovery sleep (TIB = 9 h). Polysomnography was obtained on two baseline, three manipulation, and two recovery nights. Results: Across the sleep restriction nights, total SWS duration was preserved relative to the 9 h baseline sleep opportunity, while other sleep stages were reduced. Considering only the first 5 h of sleep opportunity, SR participants had reduced N1 duration and wake after sleep onset (WASO), and increased total sleep time (TST), rapid eye movement (REM) sleep, and slow wave sleep (SWS) relative to baseline. Total REM sleep, N2, and TST duration remained above baseline levels by the third recovery sleep episode. Conclusions: In spite of preservation of SWS duration over multiple nights of sleep restriction, adolescents accustomed to curtailing nocturnal sleep on school day nights evidence residual effects on sleep macro-structure, even after three nights of recovery sleep. Older teenagers may not be as resilient to successive nights of sleep restriction as is commonly believed. Citation: Ong JL, Lo JC, Gooley JJ, Chee MW. EEG changes across multiple nights of sleep restriction and recovery in adolescents: the need for sleep study. SLEEP 2016;39(6):1233–1240. PMID:27091536

  4. Restrictive chest wall disorders.

    PubMed

    Donath, Joseph; Miller, Albert

    2009-06-01

    Hypoventilation can be caused by diseases of the chest wall. Any anatomical or functional abnormality of the bony thorax increases dead space ventilation and the work of breathing, whether congenital or acquired, acute or chronic, and whether its cause is infectious, traumatic, environmental, iatrogenic, or unknown. In this article, we discuss these heterogeneous disorders from the viewpoint of the practicing nonpediatric pulmonary physician, only briefly touching on surgical, pediatric, rheumatologic, and other nonpulmonary ramifications. Emphasis is on the most common and the best researched forms of chest wall restriction, including kyphoscoliosis, fibrothorax, thoracoplasty, flail chest, and ankylosing spondylitis. Other diseases such as osteoporosis with its less well known pulmonary effects, and some rarely seen entities, are briefly discussed.

  5. Sex and race differences in caloric intake during sleep restriction in healthy adults1234

    PubMed Central

    Spaeth, Andrea M; Dinges, David F; Goel, Namni

    2014-01-01

    Background: Evidence indicates that men and African Americans may be more susceptible to weight gain resulting from sleep loss than women and whites, respectively. Increased daily caloric intake is a major behavioral mechanism that underlies the relation between sleep loss and weight gain. Objective: We sought to assess sex and race differences in caloric intake, macronutrient intake, and meal timing during sleep restriction. Design: Forty-four healthy adults aged 21–50 y (mean ± SD: 32.7 ± 8.7 y; n = 21 women, n = 16 whites) completed an in-laboratory protocol that included 2 consecutive baseline nights [10 or 12 h time in bed (TIB)/night; 2200–0800 or 2200–1000] followed by 5 consecutive sleep-restriction nights (4 h TIB/night; 0400–0800). Caloric intake and meal-timing data were collected during the 2 d after baseline sleep and the first 3 d after sleep restriction. Results: During sleep restriction, subjects increased daily caloric intake (P < 0.001) and fat intake (P = 0.024), including obtaining more calories from condiments, desserts, and salty snacks (Ps < 0.05) and consumed 532.6 ± 295.6 cal during late-night hours (2200–0359). Relative to women, men consumed more daily calories during baseline and sleep restriction, exhibited a greater increase in caloric intake during sleep restriction (d = 0.62), and consumed a higher percentage of daily calories during late-night hours (d = 0.78, Ps < 0.05). African Americans and whites did not significantly differ in daily caloric intake, increased caloric intake during sleep restriction, or meal timing. However, African Americans consumed more carbohydrates, less protein, and more caffeine-free soda and juice than whites did during the study (Ps < 0.05). Conclusions: Men may be more susceptible to weight gain during sleep loss than women due to a larger increase in daily caloric intake, particularly during late-night hours. These findings are relevant to the promotion of public health awareness by

  6. Sleep Restriction Impairs Vocabulary Learning when Adolescents Cram for Exams: The Need for Sleep Study

    PubMed Central

    Huang, Sha; Deshpande, Aadya; Yeo, Sing-Chen; Lo, June C.; Chee, Michael W.L.; Gooley, Joshua J.

    2016-01-01

    Study Objectives: The ability to recall facts is improved when learning takes place at spaced intervals, or when sleep follows shortly after learning. However, many students cram for exams and trade sleep for other activities. The aim of this study was to examine the interaction of study spacing and time in bed (TIB) for sleep on vocabulary learning in adolescents. Methods: In the Need for Sleep Study, which used a parallel-group design, 56 adolescents aged 15–19 years were randomly assigned to a week of either 5 h or 9 h of TIB for sleep each night as part of a 14-day protocol conducted at a boarding school. During the sleep manipulation period, participants studied 40 Graduate Record Examination (GRE)-type English words using digital flashcards. Word pairs were presented over 4 consecutive days (spaced items), or all at once during single study sessions (massed items), with total study time kept constant across conditions. Recall performance was examined 0 h, 24 h, and 120 h after all items were studied. Results: For all retention intervals examined, recall of massed items was impaired by a greater amount in adolescents exposed to sleep restriction. In contrast, cued recall performance on spaced items was similar between sleep groups. Conclusions: Spaced learning conferred strong protection against the effects of sleep restriction on recall performance, whereas students who had insufficient sleep were more likely to forget items studied over short time intervals. These findings in adolescents demonstrate the importance of combining good study habits and good sleep habits to optimize learning outcomes. Citation: Huang S, Deshpande A, Yeo SC, Lo JC, Chee MW, Gooley JJ. Sleep restriction impairs vocabulary learning when adolescents cram for exams: the Need for Sleep Study. SLEEP 2016;39(9):1681–1690. PMID:27253768

  7. Restrictive vs. non-restrictive composition: a magnetoencephalography study

    PubMed Central

    Leffel, Timothy; Lauter, Miriam; Westerlund, Masha; Pylkkänen, Liina

    2014-01-01

    Recent research on the brain mechanisms underlying language processing has implicated the left anterior temporal lobe (LATL) as a central region for the composition of simple phrases. Because these studies typically present their critical stimuli without contextual information, the sensitivity of LATL responses to contextual factors is unknown. In this magnetoencephalography (MEG) study, we employed a simple question-answer paradigm to manipulate whether a prenominal adjective or determiner is interpreted restrictively, i.e., as limiting the set of entities under discussion. Our results show that the LATL is sensitive to restriction, with restrictive composition eliciting higher responses than non-restrictive composition. However, this effect was only observed when the restricting element was a determiner, adjectival stimuli showing the opposite pattern, which we hypothesise to be driven by the special pragmatic properties of non-restrictive adjectives. Overall, our results demonstrate a robust sensitivity of the LATL to high level contextual and potentially also pragmatic factors. PMID:25379512

  8. The effects of sleep restriction and sleep deprivation in producing false memories.

    PubMed

    Chatburn, Alex; Kohler, Mark J; Payne, Jessica D; Drummond, Sean P A

    2017-01-01

    False memory has been claimed to be the result of an associative process of generalisation, as well as to be representative of memory errors. These can occur at any stage of memory encoding, consolidation, or retrieval, albeit through varied mechanisms. The aim of this paper is to experimentally determine: (i) if cognitive dysfunction brought about by sleep loss at the time of stimulus encoding can influence false memory production; and (ii) whether this relationship holds across sensory modalities. Subjects undertook both the Deese-Roedigger-McDermott (DRM) false memory task and a visual task designed to produce false memories. Performance was measured while subjects were well-rested (9h Time in Bed or TIB), and then again when subjects were either sleep restricted (4h TIB for 4 nights) or sleep deprived (30h total SD). Results indicate (1) that partial and total sleep loss produced equivalent effects in terms of false and veridical verbal memory, (2) that subjects performed worse after sleep loss (regardless of whether this was partial or total sleep loss) on cued recognition-based false and veridical verbal memory tasks, and that sleep loss interfered with subjects' ability to recall veridical, but not false memories under free recall conditions, and (3) that there were no effects of sleep loss on a visual false memory task. This is argued to represent the dysfunction and slow repair of an online verbal associative process in the brain following inadequate sleep.

  9. EEG Changes across Multiple Nights of Sleep Restriction and Recovery in Adolescents: The Need for Sleep Study.

    PubMed

    Ong, Ju Lynn; Lo, June C; Gooley, Joshua J; Chee, Michael W L

    2016-06-01

    To investigate sleep EEG changes in adolescents across 7 nights of sleep restriction to 5 h time in bed [TIB]) and 3 recovery nights of 9 h TIB. A parallel-group design, quasi-laboratory study was conducted in a boarding school. Fifty-five healthy adolescents (25 males, age = 15-19 y) who reported habitual TIBs of approximately 6 h on week nights (group average) but extended their sleep on weekends were randomly assigned to Sleep Restriction (SR) or Control groups. Participants underwent a 2-week protocol comprising 3 baseline nights (TIB = 9 h), 7 nights of sleep opportunity manipulation (TIB = 5 h for the SR and 9 h for the Control group), and 3 nights of recovery sleep (TIB = 9 h). Polysomnography was obtained on two baseline, three manipulation, and two recovery nights. Across the sleep restriction nights, total SWS duration was preserved relative to the 9 h baseline sleep opportunity, while other sleep stages were reduced. Considering only the first 5 h of sleep opportunity, SR participants had reduced N1 duration and wake after sleep onset (WASO), and increased total sleep time (TST), rapid eye movement (REM) sleep, and slow wave sleep (SWS) relative to baseline. Total REM sleep, N2, and TST duration remained above baseline levels by the third recovery sleep episode. In spite of preservation of SWS duration over multiple nights of sleep restriction, adolescents accustomed to curtailing nocturnal sleep on school day nights evidence residual effects on sleep macro-structure, even after three nights of recovery sleep. Older teenagers may not be as resilient to successive nights of sleep restriction as is commonly believed. © 2016 Associated Professional Sleep Societies, LLC.

  10. Assessing the benefits of napping and short rest breaks on processing speed in sleep-restricted adolescents.

    PubMed

    Lim, Julian; Lo, June C; Chee, Michael W L

    2017-04-01

    Achievement-oriented adolescents often study long hours under conditions of chronic sleep restriction, adversely affecting cognitive function. Here, we studied how napping and rest breaks (interleaved off-task periods) might ameliorate the negative effects of sleep restriction on processing speed. Fifty-seven healthy adolescents (26 female, age = 15-19 years) participated in a 15-day live-in protocol. All participants underwent sleep restriction (5 h time-in-bed), but were then randomized into two groups: one of these groups received a daily 1-h nap opportunity. Data from seven of the study days (sleep restriction days 1-5, and recovery days 1-2) are reported here. The Blocked Symbol Decoding Test, administered once a day, was used to assess time-on-task effects and the effects of rest breaks on processing speed. Controlling for baseline differences, participants who took a nap demonstrated faster speed of processing and greater benefit across testing sessions from practice. These participants were also affected significantly less by time-on-task effects. In contrast, participants who did not receive a nap benefited more from the rest breaks that were permitted between blocks of the test. Our results indicate that napping partially reverses the detrimental effects of sleep restriction on processing speed. However, rest breaks have a greater effect as a countermeasure against poor performance when sleep pressure is higher. These data add to the growing body of evidence showing the importance of sleep for good cognitive functioning in adolescents, and suggest that more frequent rest breaks might be important in situations where sleep loss is unavoidable.

  11. Metabolic and hormonal effects of ‘catch-up’ sleep in men with chronic, repetitive, lifestyle-driven sleep restriction

    PubMed Central

    Killick, Roo; Hoyos, Camilla M.; Melehan, Kerri; Dungan, George C.; Poh, Jonathon; Liu, Peter Y.

    2016-01-01

    Summary Objective Acutely restricting sleep worsens insulin sensitivity in healthy individuals whose usual sleep is normal in duration and pattern. The effect of recovery or weekend ‘catch-up’ sleep on insulin sensitivity and metabolically active hormones in individuals with chronic sleep restriction who regularly ‘catch-up’ on sleep at weekends is as yet unstudied. Design 19 men (mean ± SEM age 28.6±2.0years, BMI 26.0±0.8kg/m2) with at least 6 months’ history (5.1±0.9years) of lifestyle driven, restricted sleep during the working week (373±6.6 min/night) with regular weekend ‘catch up’ sleep (weekend sleep extension 37.4±2.3%) completed an in-laboratory, randomised, cross-over study comprising 2 of 3 conditions, stratified by age. Conditions were 3 weekend nights of 10 hours, 6 hours or 10 hours time-in-bed with slow wave sleep suppression using targeted acoustic stimuli. Measurements Insulin sensitivity was measured in the morning following the 3rd intervention night by minimal modelling of 19 samples collected during a 2 hour oral glucose tolerance test. Glucose, insulin, c-peptide, leptin, peptide YY, ghrelin, cortisol, testosterone and luteinising hormone (LH) were measured from daily fasting blood samples; HOMA-IR, HOMA-β and QUICKI were calculated. Results Insulin sensitivity was higher following 3 nights of sleep extension compared to sustained sleep restriction. Fasting insulin, c-peptide, HOMA-IR, HOMA-β, leptin and PYY decreased with ‘catch-up’ sleep, QUICKI and testosterone increased, while morning cortisol and LH did not change. Targeted acoustic stimuli reduced SWS by 23%, but did not alter insulin sensitivity. Conclusions Three nights of ‘catch-up’ sleep improved insulin sensitivity in men with chronic, repetitive sleep restriction. Methods to improve metabolic health by optimising sleep are plausible. PMID:25683266

  12. Retroviral restriction: nature's own solution.

    PubMed

    Jones, Christopher E; McKnight, Áine

    2016-12-01

    The present review will discuss recent advances in the development of anti-HIV therapies inspired by studies of the mechanisms of host restriction factor-mediated resistance to HIV infection. Manipulating the interplay between host cell restriction factors and viral accessory factors that overcome them can potentially be therapeutically useful. Preliminarily successful therapies - some of which are entering clinical trials - either inhibit the ability of virus to evade restriction factor-mediated immunity, or promote intracellular levels of restriction factors. These aims are achieved by multiple means, which are discussed. Many restriction factors appear to provide potentially useful targets for anti-HIV therapies, so time and interest should be invested in investigating ways to successfully therapeutically manipulate restriction factor-mediated immunity.

  13. Cognitive Workload and Sleep Restriction Interact to Influence Sleep Homeostatic Responses

    PubMed Central

    Goel, Namni; Abe, Takashi; Braun, Marcia E.; Dinges, David F.

    2014-01-01

    Study Objectives: Determine the effects of high versus moderate workload on sleep physiology and neurobehavioral measures, during sleep restriction (SR) and no sleep restriction (NSR) conditions. Design: Ten-night experiment involving cognitive workload and SR manipulations. Setting: Controlled laboratory environment. Participants: Sixty-three healthy adults (mean ± standard deviation: 33.2 ± 8.7 y; 29 females), age 22–50 y. Interventions: Following three baseline 8 h time in bed (TIB) nights, subjects were randomized to one of four conditions: high cognitive workload (HW) + SR; moderate cognitive workload (MW) + SR; HW + NSR; or MW + NSR. SR entailed 5 consecutive nights at 4 h TIB; NSR entailed 5 consecutive nights at 8 h TIB. Subjects received three workload test sessions/day consisting of 15-min preworkload assessments, followed by a 60-min (MW) or 120-min (HW) workload manipulation comprised of visually based cognitive tasks, and concluding with 15-min of postworkload assessments. Experimental nights were followed by two 8-h TIB recovery sleep nights. Polysomnography was collected on baseline night 3, experimental nights 1, 4, and 5, and recovery night 1 using three channels (central, frontal, occipital [C3, Fz, O2]). Measurements and Results: High workload, regardless of sleep duration, increased subjective fatigue and sleepiness (all P < 0.05). In contrast, sleep restriction produced cumulative increases in Psychomotor Vigilance Test (PVT) lapses, fatigue, and sleepiness and decreases in PVT response speed and Maintenance of Wakefulness Test (MWT) sleep onset latencies (all P < 0.05). High workload produced longer sleep onset latencies (P < 0.05, d = 0.63) and less wake after sleep onset (P < 0.05, d = 0.64) than moderate workload. Slow-wave energy—the putative marker of sleep homeostasis—was higher at O2 than C3 only in the HW + SR condition (P < 0.05). Conclusions: High cognitive workload delayed sleep onset, but it also promoted sleep homeostatic

  14. Sleep Restriction Impairs Vocabulary Learning when Adolescents Cram for Exams: The Need for Sleep Study.

    PubMed

    Huang, Sha; Deshpande, Aadya; Yeo, Sing-Chen; Lo, June C; Chee, Michael W L; Gooley, Joshua J

    2016-09-01

    The ability to recall facts is improved when learning takes place at spaced intervals, or when sleep follows shortly after learning. However, many students cram for exams and trade sleep for other activities. The aim of this study was to examine the interaction of study spacing and time in bed (TIB) for sleep on vocabulary learning in adolescents. In the Need for Sleep Study, which used a parallel-group design, 56 adolescents aged 15-19 years were randomly assigned to a week of either 5 h or 9 h of TIB for sleep each night as part of a 14-day protocol conducted at a boarding school. During the sleep manipulation period, participants studied 40 Graduate Record Examination (GRE)-type English words using digital flashcards. Word pairs were presented over 4 consecutive days (spaced items), or all at once during single study sessions (massed items), with total study time kept constant across conditions. Recall performance was examined 0 h, 24 h, and 120 h after all items were studied. For all retention intervals examined, recall of massed items was impaired by a greater amount in adolescents exposed to sleep restriction. In contrast, cued recall performance on spaced items was similar between sleep groups. Spaced learning conferred strong protection against the effects of sleep restriction on recall performance, whereas students who had insufficient sleep were more likely to forget items studied over short time intervals. These findings in adolescents demonstrate the importance of combining good study habits and good sleep habits to optimize learning outcomes. © 2016 Associated Professional Sleep Societies, LLC.

  15. Cognitive workload and sleep restriction interact to influence sleep homeostatic responses.

    PubMed

    Goel, Namni; Abe, Takashi; Braun, Marcia E; Dinges, David F

    2014-11-01

    Determine the effects of high versus moderate workload on sleep physiology and neurobehavioral measures, during sleep restriction (SR) and no sleep restriction (NSR) conditions. Ten-night experiment involving cognitive workload and SR manipulations. Controlled laboratory environment. Sixty-three healthy adults (mean ± standard deviation: 33.2 ± 8.7 y; 29 females), age 22-50 y. Following three baseline 8 h time in bed (TIB) nights, subjects were randomized to one of four conditions: high cognitive workload (HW) + SR; moderate cognitive workload (MW) + SR; HW + NSR; or MW + NSR. SR entailed 5 consecutive nights at 4 h TIB; NSR entailed 5 consecutive nights at 8 h TIB. Subjects received three workload test sessions/day consisting of 15-min preworkload assessments, followed by a 60-min (MW) or 120-min (HW) workload manipulation comprised of visually based cognitive tasks, and concluding with 15-min of postworkload assessments. Experimental nights were followed by two 8-h TIB recovery sleep nights. Polysomnography was collected on baseline night 3, experimental nights 1, 4, and 5, and recovery night 1 using three channels (central, frontal, occipital [C3, Fz, O2]). High workload, regardless of sleep duration, increased subjective fatigue and sleepiness (all P < 0.05). In contrast, sleep restriction produced cumulative increases in Psychomotor Vigilance Test (PVT) lapses, fatigue, and sleepiness and decreases in PVT response speed and Maintenance of Wakefulness Test (MWT) sleep onset latencies (all P < 0.05). High workload produced longer sleep onset latencies (P < 0.05, d = 0.63) and less wake after sleep onset (P < 0.05, d = 0.64) than moderate workload. Slow-wave energy-the putative marker of sleep homeostasis-was higher at O2 than C3 only in the HW + SR condition (P < 0.05). High cognitive workload delayed sleep onset, but it also promoted sleep homeostatic responses by increasing subjective fatigue and sleepiness, and producing a global sleep homeostatic response

  16. AGU Sonar Data Restriction Panel

    NASA Astrophysics Data System (ADS)

    The AGU Council accepted the report of the panel set up in February to study the issue of restriction by the U.S. Navy of access to high-resolution sonar data for the U.S. Exclusive Economic Zone. Panel chairman John Bossier announced that “the Navy has acted in the best interests of the nation” in lifting the restriction order. Only two areas, egress routes to two submarine bases (see “Navy Defines Areas Under Sonar Ban,” in News, this issue), remain restricted.Panel members were Bruce Douglas, Alexander Malahoff, Donald Piepgras, Paul Richards, David Smith and Manik Talwani.

  17. The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation

    NASA Technical Reports Server (NTRS)

    Van Dongen, Hans P A.; Maislin, Greg; Mullington, Janet M.; Dinges, David F.

    2003-01-01

    OBJECTIVES: To inform the debate over whether human sleep can be chronically reduced without consequences, we conducted a dose-response chronic sleep restriction experiment in which waking neurobehavioral and sleep physiological functions were monitored and compared to those for total sleep deprivation. DESIGN: The chronic sleep restriction experiment involved randomization to one of three sleep doses (4 h, 6 h, or 8 h time in bed per night), which were maintained for 14 consecutive days. The total sleep deprivation experiment involved 3 nights without sleep (0 h time in bed). Each study also involved 3 baseline (pre-deprivation) days and 3 recovery days. SETTING: Both experiments were conducted under standardized laboratory conditions with continuous behavioral, physiological and medical monitoring. PARTICIPANTS: A total of n = 48 healthy adults (ages 21-38) participated in the experiments. INTERVENTIONS: Noctumal sleep periods were restricted to 8 h, 6 h or 4 h per day for 14 days, or to 0 h for 3 days. All other sleep was prohibited. RESULTS: Chronic restriction of sleep periods to 4 h or 6 h per night over 14 consecutive days resulted in significant cumulative, dose-dependent deficits in cognitive performance on all tasks. Subjective sleepiness ratings showed an acute response to sleep restriction but only small further increases on subsequent days, and did not significantly differentiate the 6 h and 4 h conditions. Polysomnographic variables and delta power in the non-REM sleep EEG-a putative marker of sleep homeostasis--displayed an acute response to sleep restriction with negligible further changes across the 14 restricted nights. Comparison of chronic sleep restriction to total sleep deprivation showed that the latter resulted in disproportionately large waking neurobehavioral and sleep delta power responses relative to how much sleep was lost. A statistical model revealed that, regardless of the mode of sleep deprivation, lapses in behavioral alertness

  18. The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation

    NASA Technical Reports Server (NTRS)

    Van Dongen, Hans P A.; Maislin, Greg; Mullington, Janet M.; Dinges, David F.

    2003-01-01

    OBJECTIVES: To inform the debate over whether human sleep can be chronically reduced without consequences, we conducted a dose-response chronic sleep restriction experiment in which waking neurobehavioral and sleep physiological functions were monitored and compared to those for total sleep deprivation. DESIGN: The chronic sleep restriction experiment involved randomization to one of three sleep doses (4 h, 6 h, or 8 h time in bed per night), which were maintained for 14 consecutive days. The total sleep deprivation experiment involved 3 nights without sleep (0 h time in bed). Each study also involved 3 baseline (pre-deprivation) days and 3 recovery days. SETTING: Both experiments were conducted under standardized laboratory conditions with continuous behavioral, physiological and medical monitoring. PARTICIPANTS: A total of n = 48 healthy adults (ages 21-38) participated in the experiments. INTERVENTIONS: Noctumal sleep periods were restricted to 8 h, 6 h or 4 h per day for 14 days, or to 0 h for 3 days. All other sleep was prohibited. RESULTS: Chronic restriction of sleep periods to 4 h or 6 h per night over 14 consecutive days resulted in significant cumulative, dose-dependent deficits in cognitive performance on all tasks. Subjective sleepiness ratings showed an acute response to sleep restriction but only small further increases on subsequent days, and did not significantly differentiate the 6 h and 4 h conditions. Polysomnographic variables and delta power in the non-REM sleep EEG-a putative marker of sleep homeostasis--displayed an acute response to sleep restriction with negligible further changes across the 14 restricted nights. Comparison of chronic sleep restriction to total sleep deprivation showed that the latter resulted in disproportionately large waking neurobehavioral and sleep delta power responses relative to how much sleep was lost. A statistical model revealed that, regardless of the mode of sleep deprivation, lapses in behavioral alertness

  19. Methionine restriction and lifespan control

    PubMed Central

    Lee, Byung Cheon; Kaya, Alaattin; Gladyshev, Vadim N.

    2016-01-01

    Dietary restriction (DR) without malnutrition is associated with longevity in various organisms. However, it has also been shown that reduced calorie intake is often ineffective in extending lifespan. Selecting optimal dietary regimens for DR studies is complicated, as the same regimen may lead to different outcomes depending on genotype and environmental factors. Recent studies suggested that interventions such as moderate protein restriction with/without adequate nutrition (e.g. particular amino acids or carbohydrates) may have additional beneficial effects mediated by certain metabolic and hormonal factors implicated in the biology of aging, regardless of total calorie intake. In particular, it was shown that restriction of a single amino acid, methionine, can mimic the effects of DR and extend lifespan in various model organisms. We discuss beneficial effects of methionine-restricted (MR) diet, the molecular pathways involved, and the use of this regimen in longevity interventions. PMID:26663138

  20. Genetics Home Reference: familial restrictive cardiomyopathy

    MedlinePlus

    ... Home Health Conditions familial restrictive cardiomyopathy familial restrictive cardiomyopathy Printable PDF Open All Close All Enable Javascript ... view the expand/collapse boxes. Description Familial restrictive cardiomyopathy is a genetic form of heart disease. For ...

  1. The dangers of lithotomy positioning in the operating room: case report of bilateral lower extremity compartment syndrome after a 90-minutes surgical procedure.

    PubMed

    Stornelli, Nicole; Wydra, Frank B; Mitchell, Justin J; Stahel, Philip F; Fabbri, Stefka

    2016-01-01

    Lower extremity acute compartment syndrome after gynecologic surgery in the lithotomy position is a rare, yet potentially devastating complication. A high level of suspicion is paramount for early recognition and mitigation of acute compartment syndrome originating from prolonged surgery in lithotomy position. A 23-year-old female, gravida 1, para 0, underwent a laparoscopic salpingectomy for a ruptured ectopic pregnancy. Surgical time was 90 min. Postoperatively, the patient developed acute compartment syndrome of both legs necessitating emergent bilateral four-compartment fasciotomies, with repeated returns to the operating room for 2nd look procedures and delayed wound closures. The patient regained full function within 3 months and returned to an unrestricted baseline activity level. Technical diligence in applying a lithotomy position is paramount for preventing postoperative lower extremity compartment syndrome. A high level of suspicion for this severe complication in conjunction with early recognition and immediate surgical management can mitigate long-term adverse sequelae and improve postoperative outcomes.

  2. Maternal food restrictions during breastfeeding

    PubMed Central

    Jeong, Goun; Park, Sung Won; Lee, Yeon Kyung; Ko, Sun Young

    2017-01-01

    Purpose This study investigated self-food restriction during breastfeeding, reviewed the literature showing the effect of maternal diet on the health of breast-fed infants, and explored the validity of dietary restrictions. Methods Questionnaire data were collected from breastfeeding Korean mothers who visited the pediatric clinic of Cheil General Hospital & Women's Healthcare Center from July 2015 through August 2015. The survey included items assessing maternal age, number of children, maternal educational attainment, household income, degree of difficulty with self-food restriction, types of self-restricted foods, dietary customs during breastfeeding, and sources of information about breastfeeding. Results The questionnaire was completed by 145 mothers. More than a third (n=56, 39%) had discomfort from and usually avoided 4–5 types of food (mean, 4.92). Mothers younger than 40 years had more discomfort (odds ratio [OR], 12.762; P=0.017). Primiparas felt less discomfort than multiparas (OR, 0.436; P=0.036). Dietary practices were not influenced by maternal educational attainment or household income. The most common self-restricted foods were caffeine (n=131, 90.3%), spicy foods (n=124, 85.5%), raw foods (n=109, 75.2%), cold foods (n=100, 69%), and sikhye (traditional sweet Korean rice beverage) (n=100, 69%). Most mothers (n=122, 84.1%) avoided foods for vague reasons. Conclusion Most mothers restricted certain foods unnecessarily. Literature review identified no foods that mothers should absolutely avoid during breastfeeding unless the infant reacts negatively to the food. PMID:28392822

  3. Generalized Pump-restriction Theorem

    SciTech Connect

    Sinitsyn, Nikolai A; Chernyak, Vladimir Y

    2008-01-01

    We formulate conditions under which periodic modulations of parameters on a finite graph with stochastic transitions among its nodes do not lead to overall pump currents through any given link. Our theorem unifies previously known results with the new ones and provides a universal approach to explore futher restrictions on stochastic pump effect in non-adiabatically driven systems with detailed balance.

  4. 5 CFR 300.604 - Restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Time-In-Grade Restrictions § 300.604 Restrictions. The following time-in-grade restrictions must be met unless... may be advanced without time restriction to positions up to GS-5 if the position to be filled is...

  5. 14 CFR 1203.305 - Restricted data.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Restricted data. 1203.305 Section 1203.305... Classification Principles and Considerations § 1203.305 Restricted data. Restricted Data or Formerly Restricted Data is so classified when originated, as required by the Atomic Energy Act of 1954, as amended...

  6. 14 CFR 1203.305 - Restricted data.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Restricted data. 1203.305 Section 1203.305... Classification Principles and Considerations § 1203.305 Restricted data. Restricted Data or Formerly Restricted Data is so classified when originated, as required by the Atomic Energy Act of 1954, as amended...

  7. 14 CFR 1203.305 - Restricted data.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Restricted data. 1203.305 Section 1203.305... Classification Principles and Considerations § 1203.305 Restricted data. Restricted Data or Formerly Restricted Data is so classified when originated, as required by the Atomic Energy Act of 1954, as amended...

  8. 14 CFR 1203.305 - Restricted data.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Restricted data. 1203.305 Section 1203.305... Classification Principles and Considerations § 1203.305 Restricted data. Restricted Data or Formerly Restricted Data is so classified when originated, as required by the Atomic Energy Act of 1954, as amended...

  9. 30 CFR 57.11008 - Restricted clearance.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Restricted clearance. 57.11008 Section 57.11008... Escapeways Travelways-Surface and Underground § 57.11008 Restricted clearance. Where restricted clearance creates a hazard to persons, the restricted clearance shall be conspicuously marked....

  10. 30 CFR 56.11008 - Restricted clearance.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Restricted clearance. 56.11008 Section 56.11008 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Restricted clearance. Where restricted clearance creates a hazard to persons, the restricted clearance...

  11. 5 CFR 300.604 - Restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Time-In-Grade Restrictions § 300.604 Restrictions. The following time-in-grade restrictions must be met unless... may be advanced without time restriction to positions up to GS-5 if the position to be filled is no...

  12. 5 CFR 300.604 - Restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Time-In-Grade Restrictions § 300.604 Restrictions. The following time-in-grade restrictions must be met unless... may be advanced without time restriction to positions up to GS-5 if the position to be filled is no...

  13. 5 CFR 300.604 - Restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Time-In-Grade Restrictions § 300.604 Restrictions. The following time-in-grade restrictions must be met unless... may be advanced without time restriction to positions up to GS-5 if the position to be filled is no...

  14. 5 CFR 300.604 - Restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Time-In-Grade Restrictions § 300.604 Restrictions. The following time-in-grade restrictions must be met unless... may be advanced without time restriction to positions up to GS-5 if the position to be filled is no...

  15. 49 CFR 215.203 - Restricted cars.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Restricted cars. 215.203 Section 215.203..., DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Restricted Equipment § 215.203 Restricted cars. (a) This section restricts the operation of any railroad freight car that is— (1) More than...

  16. 49 CFR 215.203 - Restricted cars.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Restricted cars. 215.203 Section 215.203..., DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Restricted Equipment § 215.203 Restricted cars. (a) This section restricts the operation of any railroad freight car that is— (1) More than...

  17. 49 CFR 215.203 - Restricted cars.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Restricted cars. 215.203 Section 215.203..., DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Restricted Equipment § 215.203 Restricted cars. (a) This section restricts the operation of any railroad freight car that is— (1) More than...

  18. 49 CFR 215.203 - Restricted cars.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Restricted cars. 215.203 Section 215.203..., DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Restricted Equipment § 215.203 Restricted cars. (a) This section restricts the operation of any railroad freight car that is— (1) More than...

  19. 49 CFR 215.203 - Restricted cars.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Restricted cars. 215.203 Section 215.203..., DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Restricted Equipment § 215.203 Restricted cars. (a) This section restricts the operation of any railroad freight car that is— (1) More than...

  20. Overcoming Communication Restrictions in Collectives

    NASA Technical Reports Server (NTRS)

    Tumer, Kagan; Agogino, Adrian K.

    2004-01-01

    Many large distributed system are characterized by having a large number of components (eg., agents, neurons) whose actions and interactions determine a %orld utility which rates the performance of the overall system. Such collectives are often subject to communication restrictions, making it difficult for components which try to optimize their own private utilities, to take actions that also help optimize the world utility. In this article we address that coordination problem and derive four utility functions which present different compromises between how aligned a component s private utility is with the world utility and how readily that component can determine the actions that optimize its utility. The results show that the utility functions specifically derived to operate under communication restrictions outperform both traditional methods and previous collective-based methods by up to 75%.

  1. Temperature based Restricted Boltzmann Machines

    NASA Astrophysics Data System (ADS)

    Li, Guoqi; Deng, Lei; Xu, Yi; Wen, Changyun; Wang, Wei; Pei, Jing; Shi, Luping

    2016-01-01

    Restricted Boltzmann machines (RBMs), which apply graphical models to learning probability distribution over a set of inputs, have attracted much attention recently since being proposed as building blocks of multi-layer learning systems called deep belief networks (DBNs). Note that temperature is a key factor of the Boltzmann distribution that RBMs originate from. However, none of existing schemes have considered the impact of temperature in the graphical model of DBNs. In this work, we propose temperature based restricted Boltzmann machines (TRBMs) which reveals that temperature is an essential parameter controlling the selectivity of the firing neurons in the hidden layers. We theoretically prove that the effect of temperature can be adjusted by setting the parameter of the sharpness of the logistic function in the proposed TRBMs. The performance of RBMs can be improved by adjusting the temperature parameter of TRBMs. This work provides a comprehensive insights into the deep belief networks and deep learning architectures from a physical point of view.

  2. Temperature based Restricted Boltzmann Machines.

    PubMed

    Li, Guoqi; Deng, Lei; Xu, Yi; Wen, Changyun; Wang, Wei; Pei, Jing; Shi, Luping

    2016-01-13

    Restricted Boltzmann machines (RBMs), which apply graphical models to learning probability distribution over a set of inputs, have attracted much attention recently since being proposed as building blocks of multi-layer learning systems called deep belief networks (DBNs). Note that temperature is a key factor of the Boltzmann distribution that RBMs originate from. However, none of existing schemes have considered the impact of temperature in the graphical model of DBNs. In this work, we propose temperature based restricted Boltzmann machines (TRBMs) which reveals that temperature is an essential parameter controlling the selectivity of the firing neurons in the hidden layers. We theoretically prove that the effect of temperature can be adjusted by setting the parameter of the sharpness of the logistic function in the proposed TRBMs. The performance of RBMs can be improved by adjusting the temperature parameter of TRBMs. This work provides a comprehensive insights into the deep belief networks and deep learning architectures from a physical point of view.

  3. Purpose Restrictions on Information Use

    DTIC Science & Technology

    2013-06-03

    solutions. In Proceedings of the International Conference on Automated Planning and Scheduling (2011), F. Bacchus, C . Domshlak, S . Edelkamp, and M. Helmert...TITLE AND SUBTITLE Purpose Restrictions on Information Use 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) 5d...PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) Carnegie Mellon University,CyLab,Pittsburgh,PA

  4. Fetal growth restriction: current knowledge.

    PubMed

    Nardozza, Luciano Marcondes Machado; Caetano, Ana Carolina Rabachini; Zamarian, Ana Cristina Perez; Mazzola, Jaqueline Brandão; Silva, Carolina Pacheco; Marçal, Vivian Macedo Gomes; Lobo, Thalita Frutuoso; Peixoto, Alberto Borges; Araujo Júnior, Edward

    2017-05-01

    Fetal growth restriction (FGR) is a condition that affects 5-10% of pregnancies and is the second most common cause of perinatal mortality. This review presents the most recent knowledge on FGR and focuses on the etiology, classification, prediction, diagnosis, and management of the condition, as well as on its neurological complications. The Pubmed, SCOPUS, and Embase databases were searched using the term "fetal growth restriction". Fetal growth restriction (FGR) may be classified as early or late depending on the time of diagnosis. Early FGR (<32 weeks) is associated with substantial alterations in placental implantation with elevated hypoxia, which requires cardiovascular adaptation. Perinatal morbidity and mortality rates are high. Late FGR (≥32 weeks) presents with slight deficiencies in placentation, which leads to mild hypoxia and requires little cardiovascular adaptation. Perinatal morbidity and mortality rates are lower. The diagnosis of FGR may be clinical; however, an arterial and venous Doppler ultrasound examination is essential for diagnosis and follow-up. There are currently no treatments to control FGR; the time at which pregnancy is interrupted is of vital importance for protecting both the mother and fetus. Early diagnosis of FGR is very important, because it enables the identification of the etiology of the condition and adequate monitoring of the fetal status, thereby minimizing risks of premature birth and intrauterine hypoxia.

  5. Postoperative activity restrictions: any evidence?

    PubMed

    Weir, Larissa F; Nygaard, Ingrid E; Wilken, Jason; Brandt, Debra; Janz, Kathleen F

    2006-02-01

    Because of a widespread but untested belief that increased intra-abdominal pressure contributes to pelvic floor disorders, physicians commonly restrict various activities postoperatively. Our aim was to describe intra-abdominal pressures during common physical activities. Thirty women of wide age and weight ranges who were not undergoing treatment for pelvic floor disorders performed 3 repetitions of various activities while intra-abdominal pressures (baseline and maximal) were approximated via microtip rectal catheters. We calculated median peak and net pressures (centimeters of H(2)O). We assessed correlations between abdominal pressures and body mass index, abdominal circumference, and grip strength (a proxy for overall strength). P < .025 was considered significant. Median peak abdominal pressures ranged from 48 (lifting 8 lb from a counter) to 150 (lifting 35 lb from the floor), with much variation. Many activities did not raise the intra-abdominal pressure more than simply getting out of a chair, including lifting 8, 13, and 20 lb from a counter, lifting 8 or 13 lb from the floor, climbing stairs, walking briskly, or doing abdominal crunches. Body mass index and abdominal circumference each correlated positively with peak, but not net, pressures. Age and grip strength were not associated with abdominal pressure. Some activities commonly restricted postoperatively have no greater effect on intra-abdominal pressures than unavoidable activities like rising from a chair. How lifting is done impacts intra-abdominal pressure. Many current postoperative guidelines are needlessly restrictive. Further research is needed to determine whether increased intra-abdominal pressure truly promotes pelvic floor disorders. III.

  6. Restricted Transport in Small Pores

    PubMed Central

    Anderson, John L.; Quinn, John A.

    1974-01-01

    The basic hydrodynamic equations governing transport in submicron pores are reexamined. Conditions necessary for a simplified, one-dimensional treatment of the diffusion/convection process are established. Steric restrictions and Brownian motion are incorporated directly into the resulting model. Currently available fluid mechanical results are used to evaluate an upper limit on hindered diffusion; this limit is valid for small particle-to-pore ratios. Extensions of the analysis are shown to depend on numerical solutions of the related hydrodynamic problem, that of asymmetrical particle motion in a bounded fluid. PMID:4813157

  7. 9 CFR 78.20 - General restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS BRUCELLOSIS Restrictions on Interstate Movement of Bison Because of Brucellosis § 78.20 General restrictions. Bison may not be...

  8. 9 CFR 78.5 - General restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS BRUCELLOSIS Restrictions on Interstate Movement of Cattle Because of Brucellosis § 78.5 General restrictions. Cattle may not be...

  9. Temperature based Restricted Boltzmann Machines

    PubMed Central

    Li, Guoqi; Deng, Lei; Xu, Yi; Wen, Changyun; Wang, Wei; Pei, Jing; Shi, Luping

    2016-01-01

    Restricted Boltzmann machines (RBMs), which apply graphical models to learning probability distribution over a set of inputs, have attracted much attention recently since being proposed as building blocks of multi-layer learning systems called deep belief networks (DBNs). Note that temperature is a key factor of the Boltzmann distribution that RBMs originate from. However, none of existing schemes have considered the impact of temperature in the graphical model of DBNs. In this work, we propose temperature based restricted Boltzmann machines (TRBMs) which reveals that temperature is an essential parameter controlling the selectivity of the firing neurons in the hidden layers. We theoretically prove that the effect of temperature can be adjusted by setting the parameter of the sharpness of the logistic function in the proposed TRBMs. The performance of RBMs can be improved by adjusting the temperature parameter of TRBMs. This work provides a comprehensive insights into the deep belief networks and deep learning architectures from a physical point of view. PMID:26758235

  10. Restrictive management of neonatal polycythemia.

    PubMed

    Morag, Iris; Strauss, Tzipora; Lubin, Daniel; Schushan-Eisen, Irit; Kenet, Gili; Kuint, Jacob

    2011-10-01

    Partial exchange transfusion (PET) is traditionally suggested as treatment for neonates diagnosed with polycythemia. Nevertheless, justification of this treatment is controversial. We evaluated the risk for short-term complications associated with a restrictive treatment protocol for neonatal polycythemia. A retrospective cross-sectional analytical study was conducted. Three treatment groups were defined and managed according to their degree of polycythemia, defined by capillary tube filled with venous blood and manually centrifuged hematocrit: group 1, hematocrit 65 to 69% and no special treatment was recommended; group 2, hematocrit 70 to 75% and intravenous fluids were given and feedings were withheld until hematocrit decreased to < 70%; and group 3, hematocrit ≥ 76% or symptomatic neonates and PET was recommended. During the study period, 190 neonates were diagnosed with polycythemia. The overall rate of short-term complications was 15% (28 neonates). Seizures, proven necrotizing enterocolitis, or thrombosis did not occur in any participating neonates. PET was performed in 31 (16%) neonates. The groups did not differ in their rate of early neonatal morbidities or length of hospitalization. Restrictive treatment for neonatal asymptomatic polycythemia is not associated with an increased risk of short-term complications.

  11. Restricted sample variance reduces generalizability.

    PubMed

    Lakes, Kimberley D

    2013-06-01

    One factor that affects the reliability of observed scores is restriction of range on the construct measured for a particular group of study participants. This study illustrates how researchers can use generalizability theory to evaluate the impact of restriction of range in particular sample characteristics on the generalizability of test scores and to estimate how changes in measurement design could improve the generalizability of the test scores. An observer-rated measure of child self-regulation (Response to Challenge Scale; Lakes, 2011) is used to examine scores for 198 children (Grades K through 5) within the generalizability theory (GT) framework. The generalizability of ratings within relatively developmentally homogeneous samples is examined and illustrates the effect of reduced variance among ratees on generalizability. Forecasts for g coefficients of various D study designs demonstrate how higher generalizability could be achieved by increasing the number of raters or items. In summary, the research presented illustrates the importance of and procedures for evaluating the generalizability of a set of scores in a particular research context.

  12. 40 CFR 1033.740 - Credit restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 34 2013-07-01 2013-07-01 false Credit restrictions. 1033.740 Section... CONTROL OF EMISSIONS FROM LOCOMOTIVES Averaging, Banking, and Trading for Certification § 1033.740 Credit restrictions. Use of emission credits generated under this part 1033 or 40 CFR part 92 is restricted...

  13. 40 CFR 1033.740 - Credit restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 33 2014-07-01 2014-07-01 false Credit restrictions. 1033.740 Section... CONTROL OF EMISSIONS FROM LOCOMOTIVES Averaging, Banking, and Trading for Certification § 1033.740 Credit restrictions. Use of emission credits generated under this part 1033 or 40 CFR part 92 is restricted...

  14. 50 CFR 216.35 - Permit restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 10 2013-10-01 2013-10-01 false Permit restrictions. 216.35 Section 216.35 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC... MAMMALS Special Exceptions § 216.35 Permit restrictions. The following restrictions shall apply to all...

  15. 50 CFR 648.163 - Gear restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Gear restrictions. 648.163 Section 648.163... Bluefish Fishery § 648.163 Gear restrictions. If the Council determines through its annual review or framework adjustment process that gear restrictions are necessary to assure that the fishing mortality...

  16. Restriction Enzyme Mapping: A Simple Student Practical.

    ERIC Educational Resources Information Center

    Higgins, Stephen J.; And Others

    1990-01-01

    An experiment that uses the recombinant plasmid pX1108 to illustrate restriction mapping is described. The experiment involves three restriction enzymes and employs single and double restriction enzyme digestions. A list of needed materials, procedures, safety precautions, results, and discussion are included. (KR)

  17. Problem-Solving Test: Restriction Endonuclease Mapping

    ERIC Educational Resources Information Center

    Szeberenyi, Jozsef

    2011-01-01

    The term "restriction endonuclease mapping" covers a number of related techniques used to identify specific restriction enzyme recognition sites on small DNA molecules. A method for restriction endonuclease mapping of a 1,000-basepair (bp)-long DNA molecule is described in the fictitious experiment of this test. The most important fact needed to…

  18. 14 CFR 73.13 - Restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Restrictions. 73.13 Section 73.13 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRSPACE SPECIAL USE AIRSPACE Restricted Areas § 73.13 Restrictions. No person may operate an aircraft within...

  19. Problem-Solving Test: Restriction Endonuclease Mapping

    ERIC Educational Resources Information Center

    Szeberenyi, Jozsef

    2011-01-01

    The term "restriction endonuclease mapping" covers a number of related techniques used to identify specific restriction enzyme recognition sites on small DNA molecules. A method for restriction endonuclease mapping of a 1,000-basepair (bp)-long DNA molecule is described in the fictitious experiment of this test. The most important fact needed to…

  20. Restricted Schur polynomials and finite N counting

    SciTech Connect

    Collins, Storm

    2009-01-15

    Restricted Schur polynomials have been posited as orthonormal operators for the change of basis from N=4 SYM to type IIB string theory. In this paper we briefly expound the relationship between the restricted Schur polynomials and the operators forwarded by Brown, Heslop, and Ramgoolam. We then briefly examine the finite N counting of the restricted Schur polynomials.

  1. Restriction Enzyme Mapping: A Simple Student Practical.

    ERIC Educational Resources Information Center

    Higgins, Stephen J.; And Others

    1990-01-01

    An experiment that uses the recombinant plasmid pX1108 to illustrate restriction mapping is described. The experiment involves three restriction enzymes and employs single and double restriction enzyme digestions. A list of needed materials, procedures, safety precautions, results, and discussion are included. (KR)

  2. 21 CFR 203.20 - Sales restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Sales restrictions. 203.20 Section 203.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL PRESCRIPTION DRUG MARKETING Sales Restrictions § 203.20 Sales restrictions. Except as provided in § 203.22...

  3. 9 CFR 92.3 - Movement restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Movement restrictions. 92.3 Section 92... ANIMAL PRODUCTS: PROCEDURES FOR REQUESTING RECOGNITION OF REGIONS § 92.3 Movement restrictions. Whenever... exist and the EC imposes prohibitions or other restrictions on the movement of animals or animal...

  4. 7 CFR 982.14 - Restricted hazelnuts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Restricted hazelnuts. 982.14 Section 982.14... AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE HAZELNUTS GROWN IN OREGON AND WASHINGTON Order Regulating Handling Definitions § 982.14 Restricted hazelnuts. Restricted hazelnuts...

  5. 7 CFR 982.14 - Restricted hazelnuts.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Restricted hazelnuts. 982.14 Section 982.14... Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE HAZELNUTS GROWN IN OREGON AND WASHINGTON Order Regulating Handling Definitions § 982.14 Restricted hazelnuts. Restricted hazelnuts...

  6. 7 CFR 982.14 - Restricted hazelnuts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Restricted hazelnuts. 982.14 Section 982.14... Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE HAZELNUTS GROWN IN OREGON AND WASHINGTON Order Regulating Handling Definitions § 982.14 Restricted hazelnuts. Restricted hazelnuts...

  7. 7 CFR 982.14 - Restricted hazelnuts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Restricted hazelnuts. 982.14 Section 982.14... AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE HAZELNUTS GROWN IN OREGON AND WASHINGTON Order Regulating Handling Definitions § 982.14 Restricted hazelnuts. Restricted hazelnuts...

  8. 7 CFR 982.14 - Restricted hazelnuts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Restricted hazelnuts. 982.14 Section 982.14... Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE HAZELNUTS GROWN IN OREGON AND WASHINGTON Order Regulating Handling Definitions § 982.14 Restricted hazelnuts. Restricted hazelnuts...

  9. 50 CFR 648.23 - Gear restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Mackerel, Squid, and Butterfish Fisheries § 648.23 Gear restrictions. (a) Mesh restrictions and exemptions...°45.0′ 74°53.0′ M24 35°28.0′ 74°52.0′ (4) Mackerel, squid, and butterfish bottom trawling restricted areas. (i) Oceanographer Canyon. No permitted mackerel, squid, or butterfish vessel may fish with...

  10. 40 CFR 1033.740 - Credit restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Credit restrictions. 1033.740 Section... CONTROL OF EMISSIONS FROM LOCOMOTIVES Averaging, Banking, and Trading for Certification § 1033.740 Credit restrictions. Use of emission credits generated under this part 1033 or 40 CFR part 92 is restricted depending...

  11. Neurodevelopment after fetal growth restriction.

    PubMed

    Baschat, Ahmet A

    2014-01-01

    Fetal growth restriction (FGR) can emerge as a complication of placental dysfunction and increases the risk for neurodevelopmental delay. Marked elevations of umbilical artery (UA) Doppler resistance that set the stage for cardiovascular and biophysical deterioration with subsequent preterm birth characterize early-onset FGR. Minimal, or absent UA Doppler abnormalities and isolated cerebral Doppler changes with subtle deterioration and a high risk for unanticipated term stillbirth are characteristic for late-onset FGR. Nutritional deficiency manifested in lagging head growth is the most powerful predictor of developmental delay in all forms of FGR. Extremes of blood flow resistance and cardiovascular deterioration, prematurity and intracranial hemorrhage increase the risks for psychomotor delay and cerebral palsy. In late-onset FGR, regional cerebral vascular redistribution correlates with abnormal behavioral domains. Irrespective of the phenotype of FGR, prenatal tests that provide precise and independent stratification of risks for adverse neurodevelopment have yet to be determined.

  12. An Infinite Restricted Boltzmann Machine.

    PubMed

    Côté, Marc-Alexandre; Larochelle, Hugo

    2016-07-01

    We present a mathematical construction for the restricted Boltzmann machine (RBM) that does not require specifying the number of hidden units. In fact, the hidden layer size is adaptive and can grow during training. This is obtained by first extending the RBM to be sensitive to the ordering of its hidden units. Then, with a carefully chosen definition of the energy function, we show that the limit of infinitely many hidden units is well defined. As with RBM, approximate maximum likelihood training can be performed, resulting in an algorithm that naturally and adaptively adds trained hidden units during learning. We empirically study the behavior of this infinite RBM, showing that its performance is competitive to that of the RBM, while not requiring the tuning of a hidden layer size.

  13. Restrictive dermopathy and fetal behaviour.

    PubMed

    Mulder, E J; Beemer, F A; Stoutenbeek, P

    2001-07-01

    We report three siblings from consecutive pregnancies affected with restrictive dermopathy (RD). During the second pregnancy, fetal behavioural development and growth were studied extensively using ultrasound at 1-4 week intervals. Dramatic and sudden changes occurred in fetal body movements and growth but not until the end of the second trimester of pregnancy. Prominent at that time were prolonged periods of fetal quiescence and very low heart rate variability, together with abnormally executed body movements of short duration. Retarded femoral development and jerky abrupt fetal body movements (abnormal movement quality) were already present in the early second trimester of pregnancy. Facial anomalies emerged despite the presence of fetal mouth movements. The clinical features of RD were only partly explained by present knowledge of skin development and the fetal akinesia deformation sequence hypothesis. Quantitative assessment of fetal movements proved to be a poor early marker for antenatal diagnosis of this disorder.

  14. Stillbirth and fetal growth restriction.

    PubMed

    Bukowski, Radek

    2010-09-01

    The association between stillbirth and fetal growth restriction is strong and supported by a large body of evidence and clinically employed for the stillbirth prediction. However, although assessment of fetal growth is a basis of clinical practice, it is not trivial. Essentially, fetal growth is a result of the genetic growth potential of the fetus and placental function. The growth potential is the driving force of fetal growth, whereas the placenta as the sole source of nutrients and oxygen might become the rate limiting element of fetal growth if its function is impaired. Thus, placental dysfunction may prevent the fetus from reaching its full genetically determined growth potential. In this sense fetal growth and its aberration provides an insight into placental function. Fetal growth is a proxy for the test of the effectiveness of placenta, whose function is otherwise obscured during pregnancy.

  15. Parenting and restrictions in childhood epilepsy.

    PubMed

    Rodenburg, Roos; Meijer, Anne Marie; Scherphof, Charlotte; Carpay, Johannes A; Augustijn, Paul; Aldenkamp, A P; Deković, Maja

    2013-06-01

    From the overprotection literature, the predictive and interactional (moderation) effects of controlling and indulgent parenting on restrictions in children with epilepsy were examined. Parents of 73 children with epilepsy completed questionnaires on parenting, restrictions, and functional status. Predictive and moderation effects were tested using multiple regression analysis. Moderation was tested with interactive computational methods. Restrictions were significantly (R(2)=.38, FΔ=6.59***, p<.001) predicted from seizure frequency (β=.24*, p<.05), functional status (β=-.42***, p<.001), and interaction between controlling and indulgent parenting (β=.28**, p<.01). Moderation occurred predominantly for high values of control: controlling parents who were not indulgent imposed fewer restrictions. In contrast, controlling parents who were indulgent imposed more restrictions. Parents who were controlling and more indulgent imposed more restrictions. Clinicians should ask parents about parenting and restrictions. Future research should examine whether the current study's findings can be replicated. Copyright © 2013 Elsevier Inc. All rights reserved.

  16. Cardiac MRI in restrictive cardiomyopathy.

    PubMed

    Gupta, A; Singh Gulati, G; Seth, S; Sharma, S

    2012-02-01

    Restrictive cardiomyopathy (RCM) is a specific group of heart muscle disorders characterized by inadequate ventricular relaxation during diastole. This leads to diastolic dysfunction with relative preservation of systolic function. Although short axis systolic function is usually preserved in RCM, the long axis systolic function may be severely impaired. Confirmation of diagnosis and information regarding aetiology, extent of myocardial damage, and response to treatment requires imaging. Importantly, differentiation from constrictive pericarditis (CCP) is needed, as only the latter is managed surgically. Echocardiography is the initial cardiac imaging technique but cannot reliably suggest a tissue diagnosis; although recent advances, especially tissue Doppler imaging and spectral tracking, have improved its ability to differentiate RCM from CCP. Cardiac catheterization is the reference standard, but is invasive, two-dimensional, and does not aid myocardial characterization. Cardiac magnetic resonance (CMR) is a versatile technique providing anatomical, morphological and functional information. In recent years, it has been shown to provide important information regarding disease mechanisms, and also been found useful to guide treatment, assess its outcome and predict patient prognosis. This review describes the CMR features of RCM, appearances in various diseases, its overall role in patient management, and how it compares with other imaging techniques.

  17. [Constrictive pericarditis and restrictive myocardiopathy].

    PubMed

    Espínola Zavaleta, N; Maribel Vogel, L; Isaac Tazar, J; Yánac Chávez, P; Romero Cárdenas, A; Vargas Barrón, J

    1999-01-01

    The purpose of this study was to assess the clinical and echocardiographic characteristics of constrictive pericarditis (CP) and restrictive cardiomyopathy (RC) and to compare them with the results obtained with cardiac catheterization. Clinical history, electrocardiogram and X-ray were taken in all patients, and transthoracic and transesophageal echocardiography were performed. Cardiac catheterization with transmyocardial biopsy was performed on only 5 patients. Wall thickness and left ventricular dimensions were normal in all patients with CP. Wall thickness was increased in those with RC. No patients demonstrated alterations in segmental wall movement. The pericardium was thickened and abnormally bright in the 3 patients with CP. In patients with CP the percentage of atrioventricular, semilunar, pulmonary and hepatic flow changes with respiration were more than 10%. In patients with RC this flow variation was less notable. However, the percentage of systolic and diastolic flow velocity increase of hepatic veins during expiration was greater than in CP. We can conclude that M-mode, two dimensional and Doppler echocardiography is extremely useful noninvasive method to differentiate CP and RC with good correlation with cardiac catheterization.

  18. Prenatal Depression Restricts Fetal Growth

    PubMed Central

    Diego, Miguel A.; Field, Tiffany; Hernandez-Reif, Maria; Schanberg, Saul; Kuhn, Cynthia; Gonzalez-Quintero, Victor Hugo

    2009-01-01

    Objective To identify whether prenatal depression is a risk factor for fetal growth restriction. Methods Midgestation (18-20 weeks GA) estimated fetal weight and urine cortisol and birth weight and gestational age at birth data were collected on a sample of 40 depressed and 40 non-depressed women. Estimated fetal weight and birthweight data were then used to compute fetal growth rates. Results Depressed women had a 13% greater incidence of premature delivery (Odds Ratio (OR) = 2.61) and 15% greater incidence of low birthweight (OR = 4.75) than non-depressed women. Depressed women also had elevated prenatal cortisol levels (p = .006) and fetuses who were smaller (p = .001) and who showed slower fetal growth rates (p = .011) and lower birthweights (p = .008). Mediation analyses further revealed that prenatal maternal cortisol levels were a potential mediator for the relationship between maternal symptoms of depression and both gestational age at birth and the rate of fetal growth. After controlling for maternal demographic variables, prenatal maternal cortisol levels were associated with 30% of the variance in gestational age at birth and 14% of the variance in the rate of fetal growth. Conclusion Prenatal depression was associated with adverse perinatal outcomes, including premature delivery and slower fetal growth rates. Prenatal maternal cortisol levels appear to play a role in mediating these outcomes. PMID:18723301

  19. Placental Adaptations in Growth Restriction

    PubMed Central

    Zhang, Song; Regnault, Timothy R.H.; Barker, Paige L.; Botting, Kimberley J.; McMillen, Isabella C.; McMillan, Christine M.; Roberts, Claire T.; Morrison, Janna L.

    2015-01-01

    The placenta is the primary interface between the fetus and mother and plays an important role in maintaining fetal development and growth by facilitating the transfer of substrates and participating in modulating the maternal immune response to prevent immunological rejection of the conceptus. The major substrates required for fetal growth include oxygen, glucose, amino acids and fatty acids, and their transport processes depend on morphological characteristics of the placenta, such as placental size, morphology, blood flow and vascularity. Other factors including insulin-like growth factors, apoptosis, autophagy and glucocorticoid exposure also affect placental growth and substrate transport capacity. Intrauterine growth restriction (IUGR) is often a consequence of insufficiency, and is associated with a high incidence of perinatal morbidity and mortality, as well as increased risk of cardiovascular and metabolic diseases in later life. Several different experimental methods have been used to induce placental insufficiency and IUGR in animal models and a range of factors that regulate placental growth and substrate transport capacity have been demonstrated. While no model system completely recapitulates human IUGR, these animal models allow us to carefully dissect cellular and molecular mechanisms to improve our understanding and facilitate development of therapeutic interventions. PMID:25580812

  20. Osmotic pressure beyond concentration restrictions.

    PubMed

    Grattoni, Alessandro; Merlo, Manuele; Ferrari, Mauro

    2007-10-11

    Osmosis is a fundamental physical process that involves the transit of solvent molecules across a membrane separating two liquid solutions. Osmosis plays a role in many biological processes such as fluid exchange in animal cells (Cell Biochem. Biophys. 2005, 42, 277-345;1 J. Periodontol. 2007, 78, 757-7632) and water transport in plants. It is also involved in many technological applications such as drug delivery systems (Crit. Rev. Ther. Drug. 2004, 21, 477-520;3 J. Micro-Electromech. Syst. 2004, 13, 75-824) and water purification. Extensive attention has been dedicated in the past to the modeling of osmosis, starting with the classical theories of van't Hoff and Morse. These are predictive, in the sense that they do not involve adjustable parameters; however, they are directly applicable only to limited regimes of dilute solute concentrations. Extensions beyond the domains of validity of these classical theories have required recourse to fitting parameters, transitioning therefore to semiempirical, or nonpredictive models. A novel approach was presented by Granik et al., which is not a priori restricted in concentration domains, presents no adjustable parameters, and is mechanistic, in the sense that it is based on a coupled diffusion model. In this work, we examine the validity of predictive theories of osmosis, by comparison with our new experimental results, and a meta-analysis of literature data.

  1. Assessing restrictiveness of national alcohol marketing policies.

    PubMed

    Esser, Marissa B; Jernigan, David H

    2014-01-01

    To develop an approach for monitoring national alcohol marketing policies globally, an area of the World Health Organization's (WHO) Global Alcohol Strategy. Data on restrictiveness of alcohol marketing policies came from the 2002 and 2008 WHO Global Surveys on Alcohol and Health. We included four scales in a sensitivity analysis to determine optimal weights to score countries on their marketing policies and applied the selected scale to assess national marketing policy restrictiveness. Nearly, 36% of countries had no marketing restrictions. The overall restrictiveness levels were not significantly different between 2002 and 2008. The number of countries with strict marketing regulations did not differ across years. This method of monitoring alcohol marketing restrictiveness helps track progress towards implementing WHO'S Global Alcohol Strategy. Findings indicate a consistent lack of restrictive policies over time, making this a priority area for national and global action. © The Author 2014. Medical Council on Alcohol and Oxford University Press. All rights reserved.

  2. The Benefits of Calorie Restriction and Calorie Restriction Mimetics as Related to the Eye

    PubMed Central

    Anekonda, T.S.

    2010-01-01

    The effects of calorie restriction without malnutrition seem to possess many beneficial effects in numerous disease states. Recently, studies related to calorie restriction mimetics that biochemically mimic the effects of calorie restriction are also becoming increasingly popular. Both calorie restriction and calorie restriction mimetics trigger an adaptive response reminiscent of mild-stress or low-dose toxic response, which is frequently referred to as hormesis in the toxicology literature. Although some benefits of calorie restriction and calorie restriction mimetics have been studied, the role of hormesis-related pathways in the eye has not been given a special attention. This review will present the current literature on calorie restriction and calorie restriction mimetics as related to most prominent eye diseases and provide insights on the therapeutic role of hormesis in eye diseases. PMID:20844606

  3. Sleep in patients with restrictive lung disease.

    PubMed

    Won, Christine H J; Kryger, Meir

    2014-09-01

    Restrictive lung disease leads to ventilatory defects and diffusion impairments. These changes may contribute to abnormal nocturnal pathophysiology, including sleep architecture disruption and impaired ventilation and oxygenation. Patients with restrictive lung disease may suffer significant daytime fatigue and dysfunction. Hypercarbia and hypoxemia during sleep may impact progression of lung disease and related symptoms. Little is known about the impact of treatment of sleep disruption on sleep quality and overall prognosis in restrictive lung disease. This review discusses the pathophysiology of sleep and comorbid sleep disorders in restrictive lung diseases including interstitial lung disease, neuromuscular disease, and obesity hypoventilation syndrome. Published by Elsevier Inc.

  4. 42 CFR 73.13 - Restricted experiments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) Restricted experiments: (1) Experiments utilizing recombinant DNA that involve the deliberate transfer of a... agriculture. (2) Experiments involving the deliberate formation of recombinant DNA containing genes for the...

  5. 42 CFR 73.13 - Restricted experiments.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) Restricted experiments: (1) Experiments utilizing recombinant DNA that involve the deliberate transfer of a... agriculture. (2) Experiments involving the deliberate formation of recombinant DNA containing genes for the...

  6. 42 CFR 73.13 - Restricted experiments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) Restricted experiments: (1) Experiments utilizing recombinant DNA that involve the deliberate transfer of a... agriculture. (2) Experiments involving the deliberate formation of recombinant DNA containing genes for the...

  7. Restricted licensing among older drivers in Iowa.

    PubMed

    Braitman, Keli A; Chaudhary, Neil K; McCartt, Anne T

    2010-12-01

    To determine whether Iowa's license restriction program identifies older drivers who appear to be at greater crash risk and to assess compliance with license restrictions. A total of 522 drivers 70 and older who were attempting to renew their driver's licenses at licensing offices in Iowa participated in two telephone surveys: one shortly after renewal to discuss driving before renewal and another 6months later to assess any changes. Surveys assessed driving behavior, crashes, and violations as well as self-reported visual impairments, prescription medications, and physical mobility limitations. Of the 522 drivers, 232 renewed their licenses without having to take a road test (Group 1), and 290 were required to take a road test; of the drivers taking a road test, 191 renewed without restrictions (Group 2), 93 received restrictions (Group 3), and 6 had their licenses suspended (Group 4). The small number of drivers with suspensions precluded including this group in analyses. There were clear distinctions among drivers in the first three groups at the initial survey. Driver age increased across Groups 1-3, as did some visual impairments, number of prescription medications, and physical mobility limitations. Many drivers who received restrictions (Group 3) already were driving fewer miles than drivers in Groups 1-2, and were driving less often at night and on high-speed roads. Following license renewal, reported average weekly mileage decreased more among drivers with license restrictions (Group 3) (36%) than among drivers without restrictions (Groups 1-2) (4% each). For all license restriction types (headlight, geographic area, or speed), decreases in the likelihood of driving during these restricted conditions were greater for drivers with the relevant restrictions than without. Most drivers complied with restrictions. Iowa's license restriction program identifies drivers with more self-reported visual impairments, prescription medications, and physical mobility

  8. Sleep restriction masks the influence of the circadian process on sleep propensity.

    PubMed

    Sargent, Charli; Darwent, David; Ferguson, Sally A; Kennaway, David J; Roach, Gregory D

    2012-06-01

    Previous forced desynchrony studies have highlighted the close relationship between the circadian rhythms of core body temperature (CBT) and sleep propensity. In particular, these studies have shown that a "forbidden zone" for sleep exists on the rising limb of the CBT rhythm. In these previous studies, the length of the experimental day was either ultrashort (90 min), short (20 h), or long (28 h), and the ratio of sleep to wake was normal (i.e., 1:2). The aim of the current study was to examine the relative effects of the circadian and homeostatic processes on sleep propensity using a 28-h forced desynchrony protocol in which the ratio of sleep to wake was substantially lower than normal (i.e., 1:5). Twenty-seven healthy males lived in a time-isolation sleep laboratory for 11 consecutive days. Participants completed either a control (n = 13) or sleep restriction (n = 14) condition. In both conditions, the protocol consisted of 2 × 24-h baseline days followed by 8 × 28-h forced desynchrony days. On forced desynchrony days, the control group had 9.3 h in bed and 18.7 h of wake, and the sleep restriction group had 4.7 h in bed and 23.3 h of wake. For all participants, each 30-s epoch of time in bed was scored as sleep or wake based on standard polysomnography recordings, and was also assigned a circadian phase (360° = 24 h) based on a cosine equation fitted to continuously recorded CBT data. For each circadian phase (i.e., 72 × 5° bins), sleep propensity was calculated as the percentage of epochs spent in bed scored as sleep. For the control group, there was a clear circadian rhythm in sleep propensity, with a peak of 98.5% at 5° (~05:20 h), a trough of 64.9% at 245° (~21:20 h), and an average of 82.3%. In contrast, sleep propensity for the sleep restriction group was relatively high at all circadian phases, with an average of 96.7%. For this group, the highest sleep propensity (99.0%) occurred at 60° (~09:00 h), and the lowest sleep propensity (91

  9. 12 CFR 575.11 - Operating restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY MUTUAL HOLDING COMPANIES § 575.11 Operating restrictions. (a) Activities restrictions. A mutual holding company may engage in any business activity specified in 12 U.S.C. 1467a(c)(2) or (c)(9)(A)(ii). In addition, the business...

  10. 46 CFR 119.405 - Fuel restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Fuel restrictions. 119.405 Section 119.405 Shipping... Machinery Requirements § 119.405 Fuel restrictions. The use of a fuel, other than diesel fuel, as an alternative fuel for an internal combustion engine, except gasoline when used as a fuel for outboard motors...

  11. 46 CFR 119.405 - Fuel restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Fuel restrictions. 119.405 Section 119.405 Shipping... Machinery Requirements § 119.405 Fuel restrictions. The use of a fuel, other than diesel fuel, as an alternative fuel for an internal combustion engine, except gasoline when used as a fuel for outboard motors...

  12. 46 CFR 182.405 - Fuel restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Fuel restrictions. 182.405 Section 182.405 Shipping...) MACHINERY INSTALLATION Specific Machinery Requirements § 182.405 Fuel restrictions. The use of alternative fuels, other than diesel fuel or gasoline, as fuel for an internal combustion engine will be reviewed...

  13. 46 CFR 119.405 - Fuel restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Fuel restrictions. 119.405 Section 119.405 Shipping... Machinery Requirements § 119.405 Fuel restrictions. The use of a fuel, other than diesel fuel, as an alternative fuel for an internal combustion engine, except gasoline when used as a fuel for outboard motors...

  14. 46 CFR 182.405 - Fuel restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Fuel restrictions. 182.405 Section 182.405 Shipping...) MACHINERY INSTALLATION Specific Machinery Requirements § 182.405 Fuel restrictions. The use of alternative fuels, other than diesel fuel or gasoline, as fuel for an internal combustion engine will be reviewed...

  15. 46 CFR 182.405 - Fuel restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Fuel restrictions. 182.405 Section 182.405 Shipping...) MACHINERY INSTALLATION Specific Machinery Requirements § 182.405 Fuel restrictions. The use of alternative fuels, other than diesel fuel or gasoline, as fuel for an internal combustion engine will be reviewed...

  16. 46 CFR 182.405 - Fuel restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Fuel restrictions. 182.405 Section 182.405 Shipping...) MACHINERY INSTALLATION Specific Machinery Requirements § 182.405 Fuel restrictions. The use of alternative fuels, other than diesel fuel or gasoline, as fuel for an internal combustion engine will be reviewed...

  17. 46 CFR 119.405 - Fuel restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Fuel restrictions. 119.405 Section 119.405 Shipping... Machinery Requirements § 119.405 Fuel restrictions. The use of a fuel, other than diesel fuel, as an alternative fuel for an internal combustion engine, except gasoline when used as a fuel for outboard motors...

  18. 7 CFR 3550.118 - Grant restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Grant restrictions. 3550.118 Section 3550.118... AGRICULTURE DIRECT SINGLE FAMILY HOUSING LOANS AND GRANTS Section 504 Origination and Section 306C Water and Waste Disposal Grants § 3550.118 Grant restrictions. (a) Maximum grant. Lifetime assistance to any...

  19. 7 CFR 3550.118 - Grant restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Grant restrictions. 3550.118 Section 3550.118... AGRICULTURE DIRECT SINGLE FAMILY HOUSING LOANS AND GRANTS Section 504 Origination and Section 306C Water and Waste Disposal Grants § 3550.118 Grant restrictions. (a) Maximum grant. Lifetime assistance to any...

  20. 7 CFR 3555.102 - Loan restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Loan restrictions. 3555.102 Section 3555.102... AGRICULTURE GUARANTEED RURAL HOUSING PROGRAM (Eff. 9-1-14) Loan Requirements § 3555.102 Loan restrictions. A guarantee will not be issued if loan funds are to be used for: (a) Existing manufactured homes. Purchase...

  1. 50 CFR 660.506 - Gear restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Gear restrictions. 660.506 Section 660.506 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 660.506 Gear restrictions. The only fishing gear authorized for use in the reduction fishery...

  2. 50 CFR 665.104 - Gear restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Gear restrictions. 665.104 Section 665... § 665.104 Gear restrictions. (a) Bottom trawls and bottom set gillnets. Fishing for American Samoa bottomfish MUS with bottom trawls and bottom set gillnets is prohibited. (b) Possession of gear....

  3. 50 CFR 665.605 - Gear restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Gear restrictions. 665.605 Section 665... Fisheries § 665.605 Gear restrictions. (a) Bottom trawls and bottom set gillnets. Fishing for PRIA bottomfish MUS with bottom trawls and bottom set gillnets is prohibited. (b) Possession of gear....

  4. 50 CFR 665.464 - Gear restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Gear restrictions. 665.464 Section 665.464 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.464 Gear restrictions. Only selective gear may be used to harvest coral from any precious...

  5. 50 CFR 665.664 - Gear restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Gear restrictions. 665.664 Section 665.664 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Fisheries § 665.664 Gear restrictions. Only selective gear may be used to harvest coral from any...

  6. 50 CFR 665.664 - Gear restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Gear restrictions. 665.664 Section 665.664 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Fisheries § 665.664 Gear restrictions. Only selective gear may be used to harvest coral from any...

  7. 50 CFR 665.264 - Gear restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Gear restrictions. 665.264 Section 665.264 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Gear restrictions. Only selective gear may be used to harvest coral from any precious coral permit area....

  8. 50 CFR 665.264 - Gear restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Gear restrictions. 665.264 Section 665.264 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Gear restrictions. Only selective gear may be used to harvest coral from any precious coral permit area....

  9. 50 CFR 665.164 - Gear restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Gear restrictions. 665.164 Section 665.164 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.164 Gear restrictions. Only selective gear may be used to harvest coral from any precious...

  10. 50 CFR 665.164 - Gear restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Gear restrictions. 665.164 Section 665.164 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.164 Gear restrictions. Only selective gear may be used to harvest coral from any precious...

  11. 50 CFR 665.104 - Gear restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Gear restrictions. 665.104 Section 665... § 665.104 Gear restrictions. (a) Bottom trawls and bottom set gillnets. Fishing for American Samoa bottomfish MUS with bottom trawls and bottom set gillnets is prohibited. (b) Possession of gear....

  12. 50 CFR 665.664 - Gear restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Gear restrictions. 665.664 Section 665.664 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Fisheries § 665.664 Gear restrictions. Only selective gear may be used to harvest coral from any...

  13. 50 CFR 665.605 - Gear restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Gear restrictions. 665.605 Section 665... Fisheries § 665.605 Gear restrictions. (a) Bottom trawls and bottom set gillnets. Fishing for PRIA bottomfish MUS with bottom trawls and bottom set gillnets is prohibited. (b) Possession of gear....

  14. 50 CFR 665.664 - Gear restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Gear restrictions. 665.664 Section 665.664 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Fisheries § 665.664 Gear restrictions. Only selective gear may be used to harvest coral from any...

  15. 50 CFR 660.506 - Gear restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Gear restrictions. 660.506 Section 660.506 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 660.506 Gear restrictions. The only fishing gear authorized for use in the reduction fishery...

  16. 50 CFR 665.605 - Gear restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Gear restrictions. 665.605 Section 665... Fisheries § 665.605 Gear restrictions. (a) Bottom trawls and bottom set gillnets. Fishing for PRIA bottomfish MUS with bottom trawls and bottom set gillnets is prohibited. (b) Possession of gear....

  17. 50 CFR 665.406 - Gear restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Gear restrictions. 665.406 Section 665... § 665.406 Gear restrictions. (a) Bottom trawls and bottom set gillnets. Fishing for bottomfish with bottom trawls and bottom set gillnets is prohibited. (b) Possession of gear. Possession of a bottom...

  18. 50 CFR 665.406 - Gear restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Gear restrictions. 665.406 Section 665... § 665.406 Gear restrictions. (a) Bottom trawls and bottom set gillnets. Fishing for bottomfish with bottom trawls and bottom set gillnets is prohibited. (b) Possession of gear. Possession of a bottom...

  19. 50 CFR 665.664 - Gear restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Gear restrictions. 665.664 Section 665.664 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... § 665.664 Gear restrictions. Only selective gear may be used to harvest coral from any precious...

  20. 50 CFR 665.264 - Gear restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Gear restrictions. 665.264 Section 665.264 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Gear restrictions. Only selective gear may be used to harvest coral from any precious coral permit area....

  1. 50 CFR 648.203 - Gear restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Gear restrictions. 648.203 Section 648... Atlantic Herring Fishery § 648.203 Gear restrictions. (a) Midwater trawl gear may only be used by a vessel... Nantucket Lightship Area as described in § 648.81(c)(1), provided it complies with the midwater trawl...

  2. 50 CFR 665.464 - Gear restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Gear restrictions. 665.464 Section 665.464 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.464 Gear restrictions. Only selective gear may be used to harvest coral from any precious...

  3. 50 CFR 665.164 - Gear restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Gear restrictions. 665.164 Section 665.164 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.164 Gear restrictions. Only selective gear may be used to harvest coral from any precious...

  4. 50 CFR 665.264 - Gear restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Gear restrictions. 665.264 Section 665.264..., DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Hawaii Fisheries § 665.264 Gear restrictions. Only selective gear may be used to harvest coral from any precious coral permit area....

  5. 50 CFR 665.104 - Gear restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Gear restrictions. 665.104 Section 665... § 665.104 Gear restrictions. (a) Bottom trawls and bottom set gillnets. Fishing for American Samoa bottomfish MUS with bottom trawls and bottom set gillnets is prohibited. (b) Possession of gear....

  6. 50 CFR 665.164 - Gear restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Gear restrictions. 665.164 Section 665.164 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.164 Gear restrictions. Only selective gear may be used to harvest coral from any precious...

  7. 50 CFR 648.203 - Gear restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Gear restrictions. 648.203 Section 648.203... Herring Fishery § 648.203 Gear restrictions. (a) Midwater trawl gear may only be used by a vessel issued a... Lightship Area as described in § 648.81(c)(1), provided it complies with the midwater trawl gear...

  8. 50 CFR 665.104 - Gear restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Gear restrictions. 665.104 Section 665... § 665.104 Gear restrictions. (a) Bottom trawls and bottom set gillnets. Fishing for American Samoa bottomfish MUS with bottom trawls and bottom set gillnets is prohibited. (b) Possession of gear....

  9. 50 CFR 665.464 - Gear restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Gear restrictions. 665.464 Section 665.464 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... Gear restrictions. Only selective gear may be used to harvest coral from any precious coral permit area....

  10. 50 CFR 665.605 - Gear restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Gear restrictions. 665.605 Section 665... Fisheries § 665.605 Gear restrictions. (a) Bottom trawls and bottom set gillnets. Fishing for PRIA bottomfish MUS with bottom trawls and bottom set gillnets is prohibited. (b) Possession of gear....

  11. 50 CFR 665.605 - Gear restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Gear restrictions. 665.605 Section 665.605... § 665.605 Gear restrictions. (a) Bottom trawls and bottom set gillnets. Fishing for PRIA bottomfish MUS with bottom trawls and bottom set gillnets is prohibited. (b) Possession of gear. Possession of...

  12. 50 CFR 665.464 - Gear restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Gear restrictions. 665.464 Section 665.464 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.464 Gear restrictions. Only selective gear may be used to harvest coral from any precious...

  13. 50 CFR 665.406 - Gear restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Gear restrictions. 665.406 Section 665... § 665.406 Gear restrictions. (a) Bottom trawls and bottom set gillnets. Fishing for bottomfish with bottom trawls and bottom set gillnets is prohibited. (b) Possession of gear. Possession of a bottom...

  14. 50 CFR 665.164 - Gear restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Gear restrictions. 665.164 Section 665.164..., DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC American Samoa Fisheries § 665.164 Gear restrictions. Only selective gear may be used to harvest coral from any precious coral permit area....

  15. 50 CFR 665.264 - Gear restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Gear restrictions. 665.264 Section 665.264 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Gear restrictions. Only selective gear may be used to harvest coral from any precious coral permit area....

  16. 50 CFR 648.203 - Gear restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Gear restrictions. 648.203 Section 648... Atlantic Herring Fishery § 648.203 Gear restrictions. (a) Midwater trawl gear may only be used by a vessel... Nantucket Lightship Area as described in § 648.81(c)(1), provided it complies with the midwater trawl...

  17. 50 CFR 648.203 - Gear restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Gear restrictions. 648.203 Section 648... Atlantic Herring Fishery § 648.203 Gear restrictions. (a) Midwater trawl gear may only be used by a vessel... Nantucket Lightship Area as described in § 648.81(c)(1), provided it complies with the midwater trawl...

  18. 50 CFR 665.464 - Gear restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Gear restrictions. 665.464 Section 665.464 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.464 Gear restrictions. Only selective gear may be used to harvest coral from any precious...

  19. 50 CFR 665.406 - Gear restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Gear restrictions. 665.406 Section 665... § 665.406 Gear restrictions. (a) Bottom trawls and bottom set gillnets. Fishing for bottomfish with bottom trawls and bottom set gillnets is prohibited. (b) Possession of gear. Possession of a bottom...

  20. 24 CFR 850.151 - Project restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... DISABILITIES PROGRAM) HOUSING DEVELOPMENT GRANTS Project Management § 850.151 Project restrictions. (a) Owner... 24 Housing and Urban Development 4 2014-04-01 2014-04-01 false Project restrictions. 850.151... owner shall not convert the units in the project to condominium ownership or to a form of...

  1. 24 CFR 850.151 - Project restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... DISABILITIES PROGRAM) HOUSING DEVELOPMENT GRANTS Project Management § 850.151 Project restrictions. (a) Owner... 24 Housing and Urban Development 4 2013-04-01 2013-04-01 false Project restrictions. 850.151... owner shall not convert the units in the project to condominium ownership or to a form of...

  2. 24 CFR 850.151 - Project restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... DISABILITIES PROGRAM) HOUSING DEVELOPMENT GRANTS Project Management § 850.151 Project restrictions. (a) Owner... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false Project restrictions. 850.151... owner shall not convert the units in the project to condominium ownership or to a form of...

  3. 24 CFR 850.151 - Project restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... DISABILITIES PROGRAM) HOUSING DEVELOPMENT GRANTS Project Management § 850.151 Project restrictions. (a) Owner... 24 Housing and Urban Development 4 2012-04-01 2012-04-01 false Project restrictions. 850.151... owner shall not convert the units in the project to condominium ownership or to a form of...

  4. 10 CFR 110.29 - Restricted destinations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Restricted destinations. 110.29 Section 110.29 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL Licenses § 110.29 Restricted destinations. Afghanistan Andorra Angola Burma (Myanmar) Djibouti India Israel...

  5. 10 CFR 110.29 - Restricted destinations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Restricted destinations. 110.29 Section 110.29 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL Licenses § 110.29 Restricted destinations. Afghanistan Andorra Angola Burma (Myanmar) Djibouti India Israel...

  6. 10 CFR 110.29 - Restricted destinations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Restricted destinations. 110.29 Section 110.29 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL Licenses § 110.29 Restricted destinations. Afghanistan Andorra Angola Burma (Myanmar) Djibouti India Israel...

  7. 10 CFR 110.29 - Restricted destinations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Restricted destinations. 110.29 Section 110.29 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL Licenses § 110.29 Restricted destinations. Afghanistan Andorra Angola Burma (Myanmar) Djibouti India Israel...

  8. 10 CFR 110.29 - Restricted destinations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Restricted destinations. 110.29 Section 110.29 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL Licenses § 110.29 Restricted destinations. Afghanistan Andorra Angola Burma (Myanmar) Djibouti India Israel Libya...

  9. 7 CFR 3560.576 - Occupancy restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... restrictions. (a) Restrictions on conditions of occupancy. (1) No borrower or grantee will be permitted to... condition of occupancy of the housing. (2) Tenant selection should be in accordance with the loan agreement... country. For migrant farmworkers living in seasonal housing the actual dollars earned from farm labor by...

  10. 7 CFR 3560.576 - Occupancy restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... restrictions. (a) Restrictions on conditions of occupancy. (1) No borrower or grantee will be permitted to... condition of occupancy of the housing. (2) Tenant selection should be in accordance with the loan agreement... country. For migrant farmworkers living in seasonal housing the actual dollars earned from farm labor by...

  11. 7 CFR 3560.576 - Occupancy restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... restrictions. (a) Restrictions on conditions of occupancy. (1) No borrower or grantee will be permitted to... condition of occupancy of the housing. (2) Tenant selection should be in accordance with the loan agreement... country. For migrant farmworkers living in seasonal housing the actual dollars earned from farm labor by...

  12. 7 CFR 3560.576 - Occupancy restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... restrictions. (a) Restrictions on conditions of occupancy. (1) No borrower or grantee will be permitted to... condition of occupancy of the housing. (2) Tenant selection should be in accordance with the loan agreement... country. For migrant farmworkers living in seasonal housing the actual dollars earned from farm labor by...

  13. 7 CFR 3430.705 - Funding restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Funding restrictions. 3430.705 Section 3430.705 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND... ADMINISTRATIVE PROVISIONS Biomass Research and Development Initiative § 3430.705 Funding restrictions. (a...

  14. 7 CFR 3430.505 - Funding restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Funding restrictions. 3430.505 Section 3430.505 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND... Funding restrictions. (a) Construction. Funds made available for grants under this subsection shall not be...

  15. 7 CFR 3430.205 - Funding restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Funding restrictions. 3430.205 Section 3430.205 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND... ADMINISTRATIVE PROVISIONS Specialty Crop Research Initiative § 3430.205 Funding restrictions. (a) Prohibition...

  16. 7 CFR 3430.705 - Funding restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Funding restrictions. 3430.705 Section 3430.705 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND... ADMINISTRATIVE PROVISIONS Biomass Research and Development Initiative § 3430.705 Funding restrictions. (a...

  17. 7 CFR 3430.905 - Funding restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Funding restrictions. 3430.905 Section 3430.905 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND... ADMINISTRATIVE PROVISIONS New Era Rural Technology Competitive Grants Program § 3430.905 Funding restrictions. (a...

  18. 7 CFR 3430.605 - Funding restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Funding restrictions. 3430.605 Section 3430.605 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND... ADMINISTRATIVE PROVISIONS Beginning Farmer and Rancher Development Program § 3430.605 Funding restrictions. (a...

  19. 7 CFR 3430.405 - Funding restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Funding restrictions. 3430.405 Section 3430.405 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND... ADMINISTRATIVE PROVISIONS Organic Agriculture Research and Extension Initiative § 3430.405 Funding restrictions...

  20. 7 CFR 3430.605 - Funding restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Funding restrictions. 3430.605 Section 3430.605 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND... ADMINISTRATIVE PROVISIONS Beginning Farmer and Rancher Development Program § 3430.605 Funding restrictions. (a...

  1. 7 CFR 3430.505 - Funding restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Funding restrictions. 3430.505 Section 3430.505 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND... Funding restrictions. (a) Construction. Funds made available for grants under this subsection shall not be...

  2. 7 CFR 3430.605 - Funding restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Funding restrictions. 3430.605 Section 3430.605 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND... ADMINISTRATIVE PROVISIONS Beginning Farmer and Rancher Development Program § 3430.605 Funding restrictions. (a...

  3. 7 CFR 3430.705 - Funding restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Funding restrictions. 3430.705 Section 3430.705 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND... ADMINISTRATIVE PROVISIONS Biomass Research and Development Initiative § 3430.705 Funding restrictions. (a...

  4. 7 CFR 3430.305 - Funding restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Funding restrictions. 3430.305 Section 3430.305 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND... ADMINISTRATIVE PROVISIONS Agriculture and Food Research Initiative § 3430.305 Funding restrictions. (a...

  5. 7 CFR 3430.205 - Funding restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Funding restrictions. 3430.205 Section 3430.205 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND... ADMINISTRATIVE PROVISIONS Specialty Crop Research Initiative § 3430.205 Funding restrictions. (a) Prohibition...

  6. 7 CFR 3430.205 - Funding restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Funding restrictions. 3430.205 Section 3430.205 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND... ADMINISTRATIVE PROVISIONS Specialty Crop Research Initiative § 3430.205 Funding restrictions. (a) Prohibition...

  7. 7 CFR 3430.605 - Funding restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Funding restrictions. 3430.605 Section 3430.605 Agriculture Regulations of the Department of Agriculture (Continued) COOPERATIVE STATE RESEARCH, EDUCATION... § 3430.605 Funding restrictions. (a) Facility costs. Funds made available under this subpart shall not be...

  8. 7 CFR 3430.205 - Funding restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Funding restrictions. 3430.205 Section 3430.205 Agriculture Regulations of the Department of Agriculture (Continued) COOPERATIVE STATE RESEARCH, EDUCATION... Funding restrictions. (a) Prohibition against construction. Funds made available under this subpart shall...

  9. 7 CFR 3430.305 - Funding restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Funding restrictions. 3430.305 Section 3430.305 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND... ADMINISTRATIVE PROVISIONS Agriculture and Food Research Initiative § 3430.305 Funding restrictions. (a...

  10. 7 CFR 3430.205 - Funding restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Funding restrictions. 3430.205 Section 3430.205 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND... ADMINISTRATIVE PROVISIONS Specialty Crop Research Initiative § 3430.205 Funding restrictions. (a) Prohibition...

  11. 7 CFR 3430.405 - Funding restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Funding restrictions. 3430.405 Section 3430.405 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND... ADMINISTRATIVE PROVISIONS Organic Agriculture Research and Extension Initiative § 3430.405 Funding restrictions...

  12. 7 CFR 3430.605 - Funding restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Funding restrictions. 3430.605 Section 3430.605 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND... ADMINISTRATIVE PROVISIONS Beginning Farmer and Rancher Development Program § 3430.605 Funding restrictions. (a...

  13. 7 CFR 3430.305 - Funding restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Funding restrictions. 3430.305 Section 3430.305 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND... ADMINISTRATIVE PROVISIONS Agriculture and Food Research Initiative § 3430.305 Funding restrictions. (a...

  14. 7 CFR 3430.505 - Funding restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Funding restrictions. 3430.505 Section 3430.505 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND... Funding restrictions. (a) Construction. Funds made available for grants under this subsection shall not be...

  15. 7 CFR 3430.905 - Funding restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Funding restrictions. 3430.905 Section 3430.905 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND... ADMINISTRATIVE PROVISIONS New Era Rural Technology Competitive Grants Program § 3430.905 Funding restrictions. (a...

  16. 7 CFR 3430.305 - Funding restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Funding restrictions. 3430.305 Section 3430.305 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND... ADMINISTRATIVE PROVISIONS Agriculture and Food Research Initiative § 3430.305 Funding restrictions. (a...

  17. 7 CFR 3430.905 - Funding restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Funding restrictions. 3430.905 Section 3430.905 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND... ADMINISTRATIVE PROVISIONS New Era Rural Technology Competitive Grants Program § 3430.905 Funding restrictions. (a...

  18. 7 CFR 3430.405 - Funding restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Funding restrictions. 3430.405 Section 3430.405 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND... ADMINISTRATIVE PROVISIONS Organic Agriculture Research and Extension Initiative § 3430.405 Funding restrictions...

  19. 7 CFR 3430.405 - Funding restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Funding restrictions. 3430.405 Section 3430.405 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND... ADMINISTRATIVE PROVISIONS Organic Agriculture Research and Extension Initiative § 3430.405 Funding restrictions...

  20. 7 CFR 3430.705 - Funding restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Funding restrictions. 3430.705 Section 3430.705 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND... ADMINISTRATIVE PROVISIONS Biomass Research and Development Initiative § 3430.705 Funding restrictions. (a...

  1. 7 CFR 3430.505 - Funding restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Funding restrictions. 3430.505 Section 3430.505 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND... Funding restrictions. (a) Construction. Funds made available for grants under this subsection shall not be...

  2. 18 CFR 1304.410 - Navigation restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Navigation restrictions... Miscellaneous § 1304.410 Navigation restrictions. (a) Except for the placement of riprap along the shoreline... established for commercial navigation. (b) Structures shall not be located in such a way as to block...

  3. 18 CFR 1304.410 - Navigation restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 2 2014-04-01 2014-04-01 false Navigation restrictions... Miscellaneous § 1304.410 Navigation restrictions. (a) Except for the placement of riprap along the shoreline... established for commercial navigation. (b) Structures shall not be located in such a way as to block...

  4. 18 CFR 1304.410 - Navigation restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Navigation restrictions... Miscellaneous § 1304.410 Navigation restrictions. (a) Except for the placement of riprap along the shoreline... established for commercial navigation. (b) Structures shall not be located in such a way as to block...

  5. 18 CFR 1304.410 - Navigation restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 2 2013-04-01 2012-04-01 true Navigation restrictions... Miscellaneous § 1304.410 Navigation restrictions. (a) Except for the placement of riprap along the shoreline... established for commercial navigation. (b) Structures shall not be located in such a way as to block...

  6. 18 CFR 1304.410 - Navigation restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Navigation restrictions... Miscellaneous § 1304.410 Navigation restrictions. (a) Except for the placement of riprap along the shoreline... established for commercial navigation. (b) Structures shall not be located in such a way as to block...

  7. 7 CFR 400.407 - Restricted access.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Restricted access. 400.407 Section 400.407 Agriculture Regulations of the Department of Agriculture (Continued) FEDERAL CROP INSURANCE CORPORATION, DEPARTMENT OF... Social Security Account Numbers and Employer Identification Numbers § 400.407 Restricted access. The...

  8. 25 CFR 163.12 - Harvesting restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Harvesting restrictions. 163.12 Section 163.12 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GENERAL FORESTRY REGULATIONS Forest Management and Operations § 163.12 Harvesting restrictions. (a) Harvesting timber on commercial forest land...

  9. 25 CFR 163.12 - Harvesting restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Harvesting restrictions. 163.12 Section 163.12 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GENERAL FORESTRY REGULATIONS Forest Management and Operations § 163.12 Harvesting restrictions. (a) Harvesting timber on commercial forest land...

  10. 25 CFR 163.12 - Harvesting restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Harvesting restrictions. 163.12 Section 163.12 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GENERAL FORESTRY REGULATIONS Forest Management and Operations § 163.12 Harvesting restrictions. (a) Harvesting timber on commercial forest land...

  11. 25 CFR 163.12 - Harvesting restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Harvesting restrictions. 163.12 Section 163.12 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GENERAL FORESTRY REGULATIONS Forest Management and Operations § 163.12 Harvesting restrictions. (a) Harvesting timber on commercial forest land...

  12. 25 CFR 163.12 - Harvesting restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Harvesting restrictions. 163.12 Section 163.12 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GENERAL FORESTRY REGULATIONS Forest Management and Operations § 163.12 Harvesting restrictions. (a) Harvesting timber on commercial forest land...

  13. 46 CFR 182.405 - Fuel restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) MACHINERY INSTALLATION Specific Machinery Requirements § 182.405 Fuel restrictions. The use of alternative fuels, other than diesel fuel or gasoline, as fuel for an internal combustion engine will be reviewed on... 46 Shipping 7 2010-10-01 2010-10-01 false Fuel restrictions. 182.405 Section 182.405...

  14. 46 CFR 119.405 - Fuel restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Machinery Requirements § 119.405 Fuel restrictions. The use of a fuel, other than diesel fuel, as an alternative fuel for an internal combustion engine, except gasoline when used as a fuel for outboard motors as... 46 Shipping 4 2010-10-01 2010-10-01 false Fuel restrictions. 119.405 Section 119.405...

  15. 12 CFR 1807.904 - Lobbying restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 9 2013-01-01 2013-01-01 false Lobbying restrictions. 1807.904 Section 1807.904 Banks and Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY CAPITAL MAGNET FUND Terms and Conditions of Assistance § 1807.904 Lobbying restrictions. No...

  16. 12 CFR 1807.904 - Lobbying restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 10 2014-01-01 2014-01-01 false Lobbying restrictions. 1807.904 Section 1807.904 Banks and Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY CAPITAL MAGNET FUND Terms and Conditions of Assistance § 1807.904 Lobbying restrictions. No...

  17. 12 CFR 1807.904 - Lobbying restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Lobbying restrictions. 1807.904 Section 1807.904 Banks and Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY CAPITAL MAGNET FUND Terms and Conditions of Assistance § 1807.904 Lobbying restrictions. No...

  18. 12 CFR 1807.904 - Lobbying restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 9 2012-01-01 2012-01-01 false Lobbying restrictions. 1807.904 Section 1807.904 Banks and Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY CAPITAL MAGNET FUND Terms and Conditions of Assistance § 1807.904 Lobbying restrictions. No...

  19. 40 CFR 258.28 - Liquids restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Liquids restrictions. 258.28 Section... MUNICIPAL SOLID WASTE LANDFILLS Operating Criteria § 258.28 Liquids restrictions. (a) Bulk or noncontainerized liquid waste may not be placed in MSWLF units unless: (1) The waste is household waste other...

  20. 28 CFR 804.3 - Restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Restrictions. 804.3 Section 804.3 Judicial Administration COURT SERVICES AND OFFENDER SUPERVISION AGENCY FOR THE DISTRICT OF COLUMBIA ACCEPTANCE OF GIFTS § 804.3 Restrictions. (a) The Agency is not authorized to accept gifts of money, stock...

  1. 28 CFR 804.3 - Restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Restrictions. 804.3 Section 804.3 Judicial Administration COURT SERVICES AND OFFENDER SUPERVISION AGENCY FOR THE DISTRICT OF COLUMBIA ACCEPTANCE OF GIFTS § 804.3 Restrictions. (a) The Agency is not authorized to accept gifts of money, stock...

  2. 32 CFR 763.4 - Entry restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 5 2011-07-01 2011-07-01 false Entry restrictions. 763.4 Section 763.4 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY ISLANDS UNDER NAVY JURISDICTION RULES GOVERNING PUBLIC ACCESS Entry Regulations for Kaho'olawe Island, Hawaii § 763.4 Entry restrictions. (a...

  3. 32 CFR 763.4 - Entry restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Entry restrictions. 763.4 Section 763.4 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY ISLANDS UNDER NAVY JURISDICTION RULES GOVERNING PUBLIC ACCESS Entry Regulations for Kaho'olawe Island, Hawaii § 763.4 Entry restrictions. (a...

  4. 12 CFR 575.11 - Operating restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY MUTUAL HOLDING COMPANIES § 575.11 Operating restrictions. (a) Activities restrictions. A mutual holding company may engage in any... of subsidiaries of mutual holding companies may include the activities specified in § 575.10(a)(6) of...

  5. 50 CFR 648.102 - Time restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Time restrictions. 648.102 Section 648... Summer Flounder Fisheries § 648.102 Time restrictions. Link to an amendment published at 76 FR 60626... flounder from May 1 through September 30. This time period may be adjusted pursuant to the procedures in...

  6. 50 CFR 648.142 - Time restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Time restrictions. 648.142 Section 648.142... Fishery § 648.142 Time restrictions. Vessels that are not eligible for a moratorium permit under § 648.4(a... bass from May 22 through October 11 and November 1 through December 31, unless this time period is...

  7. 50 CFR 648.102 - Time restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Time restrictions. 648.102 Section 648.102... Flounder Fisheries § 648.102 Time restrictions. Unless otherwise specified pursuant to § 648.107, vessels... possession limit may fish for summer flounder from May 1 through September 30. This time period may be...

  8. An Event Restriction Interval Theory of Tense

    ERIC Educational Resources Information Center

    Beamer, Brandon Robert

    2012-01-01

    This dissertation presents a novel theory of tense and tense-like constructions. It is named after a key theoretical component of the theory, the event restriction interval. In Event Restriction Interval (ERI) Theory, sentences are semantically evaluated relative to an index which contains two key intervals, the evaluation interval and the event…

  9. 14 CFR 73.83 - Restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Restrictions. 73.83 Section 73.83 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRSPACE SPECIAL USE AIRSPACE Prohibited Areas § 73.83 Restrictions. No person may operate an aircraft within...

  10. Restricted Interests and Teacher Presentation of Items

    ERIC Educational Resources Information Center

    Stocco, Corey S.; Thompson, Rachel H.; Rodriguez, Nicole M.

    2011-01-01

    Restricted and repetitive behavior (RRB) is more pervasive, prevalent, frequent, and severe in individuals with autism spectrum disorders (ASDs) than in their typical peers. One subtype of RRB is restricted interests in items or activities, which is evident in the manner in which individuals engage with items (e.g., repetitious wheel spinning),…

  11. 49 CFR 236.812 - Speed, restricted.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Speed, restricted. 236.812 Section 236.812 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Speed, restricted. A speed that will permit stopping within one-half the range of vision, but not...

  12. 49 CFR 236.812 - Speed, restricted.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Speed, restricted. 236.812 Section 236.812 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Speed, restricted. A speed that will permit stopping within one-half the range of vision, but not...

  13. 49 CFR 236.812 - Speed, restricted.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Speed, restricted. 236.812 Section 236.812 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Speed, restricted. A speed that will permit stopping within one-half the range of vision, but not...

  14. 49 CFR 236.812 - Speed, restricted.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Speed, restricted. 236.812 Section 236.812 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Speed, restricted. A speed that will permit stopping within one-half the range of vision, but not...

  15. 49 CFR 236.812 - Speed, restricted.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Speed, restricted. 236.812 Section 236.812 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Speed, restricted. A speed that will permit stopping within one-half the range of vision, but not...

  16. 49 CFR 383.95 - Restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., that the person is restricted from operating a CMV equipped with air brakes. (2) For the purposes of the skills test and the restriction, air brakes shall include any braking system operating fully or... operating a CMV in the other country. [73 FR 73125, Dec. 1, 2008]...

  17. 49 CFR 383.95 - Restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... the skills test and the restriction, air brakes include any braking system operating fully or... person is restricted from operating a CMV equipped with any braking system operating fully on the air... includes any braking system operating partially on the air brake and partially on the hydraulic...

  18. 49 CFR 383.95 - Restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... the skills test and the restriction, air brakes include any braking system operating fully or... person is restricted from operating a CMV equipped with any braking system operating fully on the air... includes any braking system operating partially on the air brake and partially on the hydraulic...

  19. 49 CFR 383.95 - Restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... the skills test and the restriction, air brakes include any braking system operating fully or... person is restricted from operating a CMV equipped with any braking system operating fully on the air... includes any braking system operating partially on the air brake and partially on the hydraulic...

  20. 7 CFR 331.13 - Restricted experiments.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 5 2014-01-01 2014-01-01 false Restricted experiments. 331.13 Section 331.13... Restricted experiments. (a) An individual or entity may not conduct, or possess products resulting from, the following experiments unless approved by and conducted in accordance with the conditions prescribed by...

  1. 42 CFR 73.13 - Restricted experiments.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Restricted experiments. 73.13 Section 73.13 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES QUARANTINE, INSPECTION, LICENSING SELECT AGENTS AND TOXINS § 73.13 Restricted experiments. (a) An individual or entity may not conduct,...

  2. 7 CFR 331.13 - Restricted experiments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 5 2013-01-01 2013-01-01 false Restricted experiments. 331.13 Section 331.13... Restricted experiments. (a) An individual or entity may not conduct, or possess products resulting from, the following experiments unless approved by and conducted in accordance with the conditions prescribed by...

  3. 50 CFR 216.35 - Permit restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS Special Exceptions § 216.35 Permit restrictions. The following restrictions shall apply to all... involving marine mammals and marine mammal parts shall comply with the regulations of this subpart. (b) The...

  4. 50 CFR 216.35 - Permit restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS Special Exceptions § 216.35 Permit restrictions. The following restrictions shall apply to all... involving marine mammals and marine mammal parts shall comply with the regulations of this subpart. (b) The...

  5. 5 CFR 330.205 - Employment restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Employment restrictions. 330.205 Section 330.205 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS RECRUITMENT, SELECTION, AND PLACEMENT (GENERAL) Reemployment Priority List (RPL) § 330.205 Employment restrictions....

  6. 5 CFR 330.205 - Employment restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Employment restrictions. 330.205 Section 330.205 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS RECRUITMENT, SELECTION, AND PLACEMENT (GENERAL) Reemployment Priority List (RPL) § 330.205 Employment restrictions....

  7. 32 CFR 806.24 - Fee restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 6 2012-07-01 2012-07-01 false Fee restrictions. 806.24 Section 806.24 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE ADMINISTRATION AIR FORCE FREEDOM OF INFORMATION ACT PROGRAM § 806.24 Fee restrictions. For FOIA purposes, Air Force activities will consider the...

  8. 32 CFR 806.24 - Fee restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Fee restrictions. 806.24 Section 806.24 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE ADMINISTRATION AIR FORCE FREEDOM OF INFORMATION ACT PROGRAM § 806.24 Fee restrictions. For FOIA purposes, Air Force activities will consider the...

  9. 32 CFR 806.24 - Fee restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 6 2014-07-01 2014-07-01 false Fee restrictions. 806.24 Section 806.24 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE ADMINISTRATION AIR FORCE FREEDOM OF INFORMATION ACT PROGRAM § 806.24 Fee restrictions. For FOIA purposes, Air Force activities will consider the...

  10. 32 CFR 806.24 - Fee restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Fee restrictions. 806.24 Section 806.24 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE ADMINISTRATION AIR FORCE FREEDOM OF INFORMATION ACT PROGRAM § 806.24 Fee restrictions. For FOIA purposes, Air Force activities will consider the...

  11. 32 CFR 806.24 - Fee restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Fee restrictions. 806.24 Section 806.24 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE ADMINISTRATION AIR FORCE FREEDOM OF INFORMATION ACT PROGRAM § 806.24 Fee restrictions. For FOIA purposes, Air Force activities will consider the...

  12. 50 CFR 648.23 - Gear restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Mackerel, Squid, and Butterfish Fisheries § 648.23 Gear restrictions. Link to an amendment published at 76...) Mackerel, squid, and butterfish bottom trawling restricted areas. (i) Oceanographer Canyon. No permitted mackerel, squid, or butterfish vessel may fish with bottom trawl gear in the Oceanographer Canyon or be...

  13. Restricting mutualistic partners to enforce trade reliance

    PubMed Central

    Wyatt, Gregory A. K.; Kiers, E. Toby; Gardner, Andy; West, Stuart A.

    2016-01-01

    Mutualisms are cooperative interactions between members of different species, often involving the trade of resources. Here, we suggest that otherwise-cooperative mutualists might be able to gain a benefit from actively restricting their partners' ability to obtain resources directly, hampering the ability of the restricted partner to survive and/or reproduce without the help of the restricting mutualist. We show that (i) restriction can be favoured when it makes the resources of the restricting individual more valuable to their partner, and thus allows them to receive more favourable terms of trade; (ii) restriction maintains cooperation in conditions where cooperative behaviour would otherwise collapse; and (iii) restriction can lead to either an increase or decrease in a restricted individual's fitness. We discuss the applicability of this scenario to mutualisms such as those between plants and mycorrhizal fungi. These results identify a novel conflict in mutualisms as well as several public goods dilemmas, but also demonstrate how conflict can help maintain cooperation. PMID:26813888

  14. Spectral Classification Using Restricted Boltzmann Machine

    NASA Astrophysics Data System (ADS)

    Fuqiang, Chen; Yan, Wu; Yude, Bu; Guodong, Zhao

    2014-01-01

    In this study, a novel machine learning algorithm, restricted Boltzmann machine, is introduced. The algorithm is applied for the spectral classification in astronomy. Restricted Boltzmann machine is a bipartite generative graphical model with two separate layers (one visible layer and one hidden layer), which can extract higher level features to represent the original data. Despite generative, restricted Boltzmann machine can be used for classification when modified with a free energy and a soft-max function. Before spectral classification, the original data are binarised according to some rule. Then, we resort to the binary restricted Boltzmann machine to classify cataclysmic variables and non-cataclysmic variables (one half of all the given data for training and the other half for testing). The experiment result shows state-of-the-art accuracy of 100%, which indicates the efficiency of the binary restricted Boltzmann machine algorithm.

  15. Near BPS skyrmions and restricted harmonic maps

    NASA Astrophysics Data System (ADS)

    Speight, J. M.

    2015-06-01

    Motivated by a class of near BPS Skyrme models introduced by Adam, Sánchez-Guillén and Wereszczyński, the following variant of the harmonic map problem is introduced: a map φ :(M, g) →(N, h) between Riemannian manifolds is restricted harmonic if it locally extremizes E2 on its SDiff(M) orbit, where SDiff(M) denotes the group of volume preserving diffeomorphisms of (M, g), and E2 denotes the Dirichlet energy. It is conjectured that near BPS skyrmions tend to restricted harmonic maps in the BPS limit. It is shown that φ is restricted harmonic if and only if φ∗ h has exact divergence, and a linear stability theory of restricted harmonic maps is developed, from which it follows that all weakly conformal maps are stable restricted harmonic. Examples of restricted harmonic maps in every degree class R3 → SU(2) and R2 →S2 are constructed. It is shown that the axially symmetric BPS skyrmions on which all previous analytic studies of near BPS Skyrme models have been based, are not restricted harmonic, casting doubt on the phenomenological predictions of such studies. The problem of minimizing E2 for φ :Rk → N over all linear volume preserving diffeomorphisms is solved explicitly, and a deformed axially symmetric family of Skyrme fields constructed which are candidates for approximate near BPS skyrmions at low baryon number. The notion of restricted harmonicity is generalized to restricted F-criticality where F is any functional on maps (M, g) →(N, h) which is, in a precise sense, geometrically natural. The case where F is a linear combination of E2 and E4, the usual Skyrme term, is studied in detail, and it is shown that inverse stereographic projection R3 →S3 ≡ SU(2) is stable restricted F-critical for every such F.

  16. Caloric restriction, caloric restriction mimetics, and healthy aging in Okinawa: controversies and clinical implications.

    PubMed

    Willcox, Bradley J; Willcox, Donald C

    2014-01-01

    To examine the role of two nutritional factors implicated in the healthy aging of the Okinawans: caloric restriction; and traditional foods with potential caloric restriction-mimetic properties. Caloric restriction is a research priority for the US National Institute on Aging. However, little is known regarding health effects in humans. Some caloric restriction-related outcomes, such as cause-specific mortality and lifespan, are not practical for human clinical trials. Therefore, epidemiological data on older Okinawans, who experienced a caloric restriction-like diet for close to half their lives, are of special interest. The nutritional data support mild caloric restriction (10-15%) and high consumption of foods that may mimic the biological effects of caloric restriction, including sweet potatoes, marine-based carotenoid-rich foods, and turmeric. Phenotypic evidence is consistent with caloric restriction (including short stature, low body weight, and lean BMI), less age-related chronic disease (including cardiovascular diseases, cancer, and dementia), and longer lifespan (mean and maximum). Both caloric restriction and traditional Okinawan functional foods with caloric restriction-mimetic properties likely had roles in the extended healthspan and lifespan of the Okinawans. More research is needed on health consequences of caloric restriction and foods with caloric restriction-mimetic properties to identify possible nutritional interventions for healthy aging.

  17. Urban water restrictions: Attitudes and avoidance

    NASA Astrophysics Data System (ADS)

    Cooper, Bethany; Burton, Michael; Crase, Lin

    2011-12-01

    In most urban cities across Australia, water restrictions remain the dominant policy mechanism to restrict urban water consumption. The extensive adoption of water restrictions as a means to limit demand, over several years, means that Australian urban water prices have consistently not reflected the opportunity cost of water. Given the generally strong political support for water restrictions and the likelihood that they will persist for some time, there is value in understanding households' attitudes in this context. More specifically, identifying the welfare gains associated with avoiding urban water restrictions entirely would be a nontrivial contribution to our knowledge and offer insights into the benefits of alternative policy responses. This paper describes the results from a contingent valuation study that investigates consumers' willingness to pay to avoid urban water restrictions. Importantly, the research also investigates the influence of cognitive and exogenous dimensions on the utility gain associated with avoiding water restrictions. The results provide insights into the impact of the current policy mechanism on economic welfare.

  18. Dietary restrictions, bone density, and bone quality.

    PubMed

    Huang, Tsang-hai; Ables, Gene P

    2016-01-01

    Caloric restriction (CR), protein restriction (PR), and specific amino acid restriction (e.g., methionine restriction (MR)) are different dietary interventions that have been confirmed with regard to their comprehensive benefits to metabolism and health. Based on bone densitometric measurements, weight loss induced by dietary restriction is known to be accompanied by reduced areal bone mineral density, bone mass, and/or bone size, and it is considered harmful to bone health. However, because of technological advancements in bone densitometric instruments (e.g., high-resolution X-ray tomography), dietary restrictions have been found to cause a reduction in bone mass/size rather than volumetric bone mineral density. Furthermore, when considering bone quality, bone health consists of diverse indices that cannot be fully represented by densitometric measurements alone. Indeed, there is evidence that moderate dietary restrictions do not impair intrinsic bone material properties, despite the reduction in whole-bone strength because of a smaller bone size. In the present review, we integrate research evidence from traditional densitometric measurements, metabolic status assays (e.g., energy metabolism, oxidative stresses, and inflammatory responses), and biomaterial analyses to provide revised conclusions regarding the effects of CR, PR, and MR on the skeleton.

  19. Caloric restriction, SIRT1 and longevity

    PubMed Central

    Cantó, Carles; Auwerx, Johan

    2013-01-01

    More than 70 years after its initial report, caloric restriction stands strong as the most consistent non-pharmacological intervention increasing lifespan and protecting against metabolic disease. Among the different mechanisms by which caloric restriction may act, Sir2/SIRT1 (Silent information regulator 2/Silent information regulator T1) has gained major attention due to its ability to integrate the sensing of the metabolic status with adaptative transcriptional outputs. This review focuses on gathered evidence suggesting that Sir2/SIRT1 is a key mediator of the beneficial effects of caloric restriction and addresses the main questions that still need to be answered to consolidate this hypothesis. PMID:19713122

  20. 9 CFR 78.5 - General restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Interstate Movement of Cattle Because of Brucellosis § 78.5 General restrictions. Cattle may not be moved interstate except in compliance with this subpart and with 9 CFR part 86. Cattle moved interstate under...

  1. 36 CFR § 331.18 - Restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... REGULATIONS GOVERNING THE PROTECTION, USE AND MANAGEMENT OF THE FALLS OF THE OHIO NATIONAL WILDLIFE CONSERVATION AREA, KENTUCKY AND INDIANA § 331.18 Restrictions. The District Engineer may establish and post a...

  2. 32 CFR 770.38 - Entry restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... in Puerto Rico § 770.38 Entry restrictions. Except for duly authorized military personnel and... duties, entry upon any U.S. Navy installation or property in Puerto Rico at anytime, by any person for...

  3. 32 CFR 770.38 - Entry restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... in Puerto Rico § 770.38 Entry restrictions. Except for duly authorized military personnel and... duties, entry upon any U.S. Navy installation or property in Puerto Rico at anytime, by any person for...

  4. Land Disposal Restrictions for Hazardous Waste

    EPA Pesticide Factsheets

    The land disposal restrictions prohibits the land disposal of untreated hazardous wastes. EPA has specified either concentration levels or methods of treatment for hazardous constituents to meet before land disposal.

  5. 9 CFR 92.3 - Movement restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... the European Commission (EC) establishes a quarantine for a disease in the European Union in a region... exist and the EC imposes prohibitions or other restrictions on the movement of animals or...

  6. 9 CFR 92.3 - Movement restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... the European Commission (EC) establishes a quarantine for a disease in the European Union in a region... exist and the EC imposes prohibitions or other restrictions on the movement of animals or...

  7. 9 CFR 92.3 - Movement restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... the European Commission (EC) establishes a quarantine for a disease in the European Union in a region... exist and the EC imposes prohibitions or other restrictions on the movement of animals or...

  8. 32 CFR 770.50 - Entry restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... LIMITING PUBLIC ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Puget Sound Naval Shipyard, Bremerton, Washington § 770.50 Entry restrictions. Except for military personnel and civilian employees...

  9. 32 CFR 770.50 - Entry restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... LIMITING PUBLIC ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Puget Sound Naval Shipyard, Bremerton, Washington § 770.50 Entry restrictions. Except for military personnel and civilian employees...

  10. 32 CFR 770.50 - Entry restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... LIMITING PUBLIC ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Puget Sound Naval Shipyard, Bremerton, Washington § 770.50 Entry restrictions. Except for military personnel and civilian employees...

  11. 32 CFR 770.50 - Entry restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... LIMITING PUBLIC ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Puget Sound Naval Shipyard, Bremerton, Washington § 770.50 Entry restrictions. Except for military personnel and civilian employees...

  12. 32 CFR 770.50 - Entry restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... LIMITING PUBLIC ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Puget Sound Naval Shipyard, Bremerton, Washington § 770.50 Entry restrictions. Except for military personnel and civilian employees...

  13. 19 CFR 12.17 - Importation restricted.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... TREASURY SPECIAL CLASSES OF MERCHANDISE Viruses, Serums, and Toxins for Treatment of Domestic Animals § 12.17 Importation restricted. The importation into the United States of viruses, serums, toxins, and...

  14. 19 CFR 12.17 - Importation restricted.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... TREASURY SPECIAL CLASSES OF MERCHANDISE Viruses, Serums, and Toxins for Treatment of Domestic Animals § 12.17 Importation restricted. The importation into the United States of viruses, serums, toxins, and...

  15. 19 CFR 12.17 - Importation restricted.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... TREASURY SPECIAL CLASSES OF MERCHANDISE Viruses, Serums, and Toxins for Treatment of Domestic Animals § 12.17 Importation restricted. The importation into the United States of viruses, serums, toxins, and...

  16. Restriction/modification polypeptides, polynucleotides, and methods

    DOEpatents

    Westpheling, Janet; Chung, DaeHwan; Huddleston, Jennifer; Farkas, Joel A

    2015-02-24

    The present invention relates to the discovery of a novel restriction/modification system in Caldicellulosiruptor bescii. The discovered restriction enzyme is a HaeIII-like restriction enzyme that possesses a thermophilic activity profile. The restriction/modification system also includes a methyltransferase, M.CbeI, that methylates at least one cytosine residue in the CbeI recognition sequence to m.sup.4C. Thus, the invention provides, in various aspects, isolated CbeI or M.CbeI polypeptides, or biologically active fragments thereof; isolated polynucleotides that encode the CbeI or M.CbeI polypeptides or biologically active fragments thereof, including expression vectors that include such polynucleotide sequences; methods of digesting DNA using a CbeI polypeptide; methods of treating a DNA molecule using a M.CbeI polypeptide; and methods of transforming a Caldicellulosiruptor cell.

  17. 46 CFR 47.630 - Restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    .... cargo vertical center of gravity tables in the U.S. Coast Guard approved stability letter, and (2) The... Service; Stability Limited Deck Cargo Barges § 47.630 Restrictions. (a) The mark (T) applies only to Great...

  18. Abortions in Texas Dropped Dramatically After Restrictions

    MedlinePlus

    ... page: https://medlineplus.gov/news/fullstory_163136.html Abortions in Texas Dropped Dramatically After Restrictions Greater travel ... later declared unconstitutional -- that increased travel distances to abortion clinics in the state seems to have led ...

  19. Dietary restriction causing iodine-deficient goitre.

    PubMed

    Cheetham, Tim; Plumb, Emma; Callaghan, James; Jackson, Michael; Michaelis, Louise

    2015-08-01

    Iodine-deficient goitre was common in some parts of the UK prior to the introduction of salt iodisation. Many contemporary salt preparations do not contain much iodine, and there are renewed concerns about the iodine status of the population. We present a boy with severe allergy who developed goitre and significant thyroid dysfunction in association with an iodine-deficient 'food-restricted' diet. The case highlights the importance of a comprehensive nutritional assessment in all children on multiple food restrictions.

  20. The design of artificial retroviral restriction factors

    SciTech Connect

    Yap, Melvyn W.; Mortuza, Gulnahar B.; Taylor, Ian A.; Stoye, Jonathan P.

    2007-09-01

    In addition to the ability to bind the retroviral capsid protein, the retroviral restriction factors Fv1, Trim5{alpha} and Trim5-CypA share the common property of containing sequences that promote self-association. Otherwise Fv1 and Trim5{alpha} appear unrelated. Mutational analyses showed that restriction was invariably lost when changes designed to disrupt the sequences responsible for multimerization were introduced. A novel restriction protein could be obtained by substituting sequences from the self-associating domain of Fv1 for the Trim5 sequences in Trim5-CypA. Similarly, a fusion protein containing cyclophilin A joined to arfaptin2, a protein known to form extended dimers, was also shown to restrict HIV-1. Hence, multimerization of a capsid-binding domain could be the common minimum design feature for capsid-dependent retroviral restriction factors. However, not all domains that promote multimerization can substitute for the N-terminal domains of Fv1 and Trim5{alpha}. Moreover, only CypA can provide a capsid-binding site with different N-terminal domains. It is suggested that the spatial relationship between the multiple target binding sites may be important for restriction.

  1. RESTRICTED INTERESTS AND TEACHER PRESENTATION OF ITEMS

    PubMed Central

    Stocco, Corey S; Thompson, Rachel H; Rodriguez, Nicole M

    2011-01-01

    Restricted and repetitive behavior (RRB) is more pervasive, prevalent, frequent, and severe in individuals with autism spectrum disorders (ASDs) than in their typical peers. One subtype of RRB is restricted interests in items or activities, which is evident in the manner in which individuals engage with items (e.g., repetitious wheel spinning), the types of items or activities they select (e.g., preoccupation with a phone book), or the range of items or activities they select (i.e., narrow range of items). We sought to describe the relation between restricted interests and teacher presentation of items. Overall, we observed 5 teachers interacting with 2 pairs of students diagnosed with an ASD. Each pair included 1 student with restricted interests. During these observations, teachers were free to present any items from an array of 4 stimuli selected by experimenters. We recorded student responses to teacher presentation of items and analyzed the data to determine the relation between teacher presentation of items and the consequences for presentation provided by the students. Teacher presentation of items corresponded with differential responses provided by students with ASD, and those with restricted preferences experienced a narrower array of items. PMID:21941381

  2. Placental Nutrient Transport and Intrauterine Growth Restriction

    PubMed Central

    Gaccioli, Francesca; Lager, Susanne

    2016-01-01

    Intrauterine growth restriction refers to the inability of the fetus to reach its genetically determined potential size. Fetal growth restriction affects approximately 5–15% of all pregnancies in the United States and Europe. In developing countries the occurrence varies widely between 10 and 55%, impacting about 30 million newborns per year. Besides having high perinatal mortality rates these infants are at greater risk for severe adverse outcomes, such as hypoxic ischemic encephalopathy and cerebral palsy. Moreover, reduced fetal growth has lifelong health consequences, including higher risks of developing metabolic and cardiovascular diseases in adulthood. Numerous reports indicate placental insufficiency as one of the underlying causes leading to altered fetal growth and impaired placental capacity of delivering nutrients to the fetus has been shown to contribute to the etiology of intrauterine growth restriction. Indeed, reduced expression and/or activity of placental nutrient transporters have been demonstrated in several conditions associated with an increased risk of delivering a small or growth restricted infant. This review focuses on human pregnancies and summarizes the changes in placental amino acid, fatty acid, and glucose transport reported in conditions associated with intrauterine growth restriction, such as maternal undernutrition, pre-eclampsia, young maternal age, high altitude and infection. PMID:26909042

  3. Type II restriction endonucleases: structure and mechanism.

    PubMed

    Pingoud, A; Fuxreiter, M; Pingoud, V; Wende, W

    2005-03-01

    Type II restriction endonucleases are components of restriction modification systems that protect bacteria and archaea against invading foreign DNA. Most are homodimeric or tetrameric enzymes that cleave DNA at defined sites of 4-8 bp in length and require Mg2+ ions for catalysis. They differ in the details of the recognition process and the mode of cleavage, indicators that these enzymes are more diverse than originally thought. Still, most of them have a similar structural core and seem to share a common mechanism of DNA cleavage, suggesting that they evolved from a common ancestor. Only a few restriction endonucleases discovered thus far do not belong to the PD...D/ExK family of enzymes, but rather have active sites typical of other endonuclease families. The present review deals with new developments in the field of Type II restriction endonucleases. One of the more interesting aspects is the increasing awareness of the diversity of Type II restriction enzymes. Nevertheless, structural studies summarized herein deal with the more common subtypes. A major emphasis of this review will be on target site location and the mechanism of catalysis, two problems currently being addressed in the literature.

  4. Cellular Restriction Factors of Feline Immunodeficiency Virus

    PubMed Central

    Zielonka, Jörg; Münk, Carsten

    2011-01-01

    Lentiviruses are known for their narrow cell- and species-tropisms, which are determined by cellular proteins whose absence or presence either support viral replication (dependency factors, cofactors) or inhibit viral replication (restriction factors). Similar to Human immunodeficiency virus type 1 (HIV-1), the cat lentivirus Feline immunodeficiency virus (FIV) is sensitive to recently discovered cellular restriction factors from non-host species that are able to stop viruses from replicating. Of particular importance are the cellular proteins APOBEC3, TRIM5α and tetherin/BST-2. In general, lentiviruses counteract or escape their species’ own variant of the restriction factor, but are targeted by the orthologous proteins of distantly related species. Most of the knowledge regarding lentiviral restriction factors has been obtained in the HIV-1 system; however, much less is known about their effects on other lentiviruses. We describe here the molecular mechanisms that explain how FIV maintains its replication in feline cells, but is largely prevented from cross-species infections by cellular restriction factors. PMID:22069525

  5. Miles In Trail (MIT) Restrictions: A Perspective

    NASA Technical Reports Server (NTRS)

    Kopardekar, Parimal; Green, Steven; Roherty, Tom; Aston, John

    2003-01-01

    Miles-in-trail restrictions are issued to meet the airport and/or airspace capacity. The purpose of this paper is to review the currently practiced miles-in-trail operations for traffic flow management at a typical en route Air Traffic Control Center. The paper describes roles and considerations of both traffic management coordinators and the controllers in planning, coordination, execution, and monitoring of miles-in-trail restrictions. The paper addresses the type of decisions that traffic management coordinators must make and the different information required to plan and monitor miles-in-trail restrictions. The implications of miles-in-trail restrictions on controller workload are also addressed. Using the Cleveland center as an example, the paper also identified some challenging traffic situations that required miles-in-trail restrictions on a regular basis. The paper is expected to benefit the research and development community as it provides the current challenges in traffic flow management and strengths and weakness of miles-in-trail operations.

  6. Newer antidiabetic drugs and calorie restriction mimicry.

    PubMed

    Kalra, Sanjay; Jacob, Jubbin Jagan; Gupta, Yashdeep

    2016-01-01

    De-acceleration of aging and delayed development of age-related morbidity accompanies the restriction of calories (without malnutrition) in laboratory mice, nematodes, yeast, fish, and dogs. Recent results from long-term longitudinal studies conducted on primates have suggested longevity benefits of a 30% restriction of calories in rhesus monkeys as well. Among calorie restricted rhesus monkeys one of the mechanisms for the improvement in lifespan was the reduction in the development of glucose intolerance and cardiovascular disease. Although there are no comparable human studies, it is likely that metabolic and longevity benefits will accompany a reduction in calories in humans as well. However, considering the difficulties in getting healthy adults to limit food intake science has focused on understanding the biochemical processes that accompany calorie restriction (CR) to formulate drugs that would mimic the effects of CR without the need to actually restrict calories. Drugs in this emerging therapeutic field are called CR mimetics. Some of the currently used anti-diabetic agents may have some CR mimetic like effects. This review focuses on the CR mimetic properties of the currently available anti-diabetic agents.

  7. The EcoR V restriction endonuclease.

    PubMed

    Luke, P A; McCallum, S A; Halford, S E

    1987-01-01

    Type II restriction endonucleases have attracted attention for two main reasons: firstly, their many applications in the dissection of DNA and in the construction of novel DNA molecules; secondly, as systems for studying the interactions of proteins with specific DNA sequences. With respect to the latter, the EcoR I restriction endonuclease has been examined in greater depth than any other type II enzyme [1-3]. However, the EcoR I enzyme has a major disadvantage as a system for studying DNA-protein interactions: the protein has a remarkably low solubility. The solutions in which EcoR I shows maximal activity, and also affinity for its recognition site, are saturated at less than 0.5 microM of this protein [4]. Consequently, many techniques that have been developed to study protein-ligand interactions but which require high concentrations of the protein in solution, such as NMR spectroscopy, cannot be used on EcoR I. But this drawback does not apply to all type II restriction enzymes. A different enzyme, the EcoR V restriction endonuclease [5-7], has special advantages as a system for studying DNA-protein interactions. In particular, this is the only type II restriction enzyme (apart from EcoR I [3]) for which crystals of the protein have been reported [7].

  8. Restricted interests and teacher presentation of items.

    PubMed

    Stocco, Corey S; Thompson, Rachel H; Rodriguez, Nicole M

    2011-01-01

    Restricted and repetitive behavior (RRB) is more pervasive, prevalent, frequent, and severe in individuals with autism spectrum disorders (ASDs) than in their typical peers. One subtype of RRB is restricted interests in items or activities, which is evident in the manner in which individuals engage with items (e.g., repetitious wheel spinning), the types of items or activities they select (e.g., preoccupation with a phone book), or the range of items or activities they select (i.e., narrow range of items). We sought to describe the relation between restricted interests and teacher presentation of items. Overall, we observed 5 teachers interacting with 2 pairs of students diagnosed with an ASD. Each pair included 1 student with restricted interests. During these observations, teachers were free to present any items from an array of 4 stimuli selected by experimenters. We recorded student responses to teacher presentation of items and analyzed the data to determine the relation between teacher presentation of items and the consequences for presentation provided by the students. Teacher presentation of items corresponded with differential responses provided by students with ASD, and those with restricted preferences experienced a narrower array of items.

  9. Counteraction of the multifunctional restriction factor tetherin

    PubMed Central

    Sauter, Daniel

    2014-01-01

    The interferon-inducible restriction factor tetherin (also known as CD317, BST-2 or HM1.24) has emerged as a key component of the antiviral immune response. Initially, tetherin was shown to restrict replication of various enveloped viruses by inhibiting the release of budding virions from infected cells. More recently, it has become clear that tetherin also acts as a pattern recognition receptor inducing NF-κB-dependent proinflammatory gene expression in virus infected cells. Whereas the ability to restrict virion release is highly conserved among mammalian tetherin orthologs and thus probably an ancient function of this protein, innate sensing seems to be an evolutionarily recent activity. The potent and broad antiviral activity of tetherin is reflected by the fact that many viruses evolved means to counteract this restriction factor. A continuous arms race with viruses has apparently driven the evolution of different isoforms of tetherin with different functional properties. Interestingly, tetherin has also been implicated in cellular processes that are unrelated to immunity, such as the organization of the apical actin network and membrane microdomains or stabilization of the Golgi apparatus. In this review, I summarize our current knowledge of the different functions of tetherin and describe the molecular strategies that viruses have evolved to antagonize or evade this multifunctional host restriction factor. PMID:24782851

  10. Fasting or caloric restriction for Healthy Aging

    PubMed Central

    Anton, Stephen; Leeuwenburgh, Christiaan

    2014-01-01

    Aging is associated with a host of biological changes that contribute to a progressive decline in cognitive and physical function, ultimately leading to a loss of independence, and increased risk of mortality. To date, prolonged caloric restriction (i.e., a reduction in caloric intake without malnutrition) is the only non-genetic intervention that has consistently been found to extend both mean and maximal life span across a variety of species. Most individuals have difficulty sustaining prolonged caloric restriction, which has led to a search for alternative approaches that can produce similar to benefits as caloric restriction. A growing body of evidence indicates that fasting periods and intermittent fasting regimens in particular can trigger similar biological pathways as caloric restriction. For this reason, there is increasing scientific interest in further exploring the biological and metabolic effects of intermittent fasting periods, as well as whether long-term compliance may be improved by this type of dietary approach. This special will highlight the latest scientific findings related to the effects of both caloric restriction and intermittent fasting across various species including yeast, fruit flies, worms, rodents, primates, and humans. A specific emphasis is placed on translational research with findings from basic bench to bedside reviewed and practical clinical implications discussed. PMID:23639403

  11. Ruminant models of prenatal growth restriction.

    PubMed

    Anthony, R V; Scheaffer, A N; Wright, C D; Regnault, T R H

    2003-01-01

    Intrauterine growth restriction (IUGR) is a significant health issue that not only affects infant mortality and morbidity, but may also predispose individuals to coronary heart disease, diabetes, hypertension and stroke as adults. The majority of IUGR pregnancies in humans are characterized by asymmetric fetal growth, resulting from inadequate nutrient transfer to the fetus. Furthermore, most of these pregnancies involve functional placental insufficiency, and may also show altered umbilical velocimetry. As the severity of IUGR increases, the fetus becomes increasingly hypoxic, hypoglycaemic and acidotic. In addition, placental transfer or utilization of some amino acids is known to be altered in IUGR pregnancies. Although a great deal has been learned from clinical studies of human IUGR, appropriate animal models are required to define completely the mechanisms involved in the development of IUGR. The pregnant sheep is a long-standing model for placental-fetal interactions, and fetal growth restriction can be induced in pregnant sheep by maternal nutrient restriction, maternal nutrient excess, administration of glucocorticoid, utero-placental embolization, carunclectomy and maternal hyperthermia. Although all of these sheep models are capable of inducing fetal growth restriction, the degree of restriction is variable. This review compares these sheep models of IUGR with the characteristics of human IUGR.

  12. Optimizing Restriction Site Placement for Synthetic Genomes

    NASA Astrophysics Data System (ADS)

    Montes, Pablo; Memelli, Heraldo; Ward, Charles; Kim, Joondong; Mitchell, Joseph S. B.; Skiena, Steven

    Restriction enzymes are the workhorses of molecular biology. We introduce a new problem that arises in the course of our project to design virus variants to serve as potential vaccines: we wish to modify virus-length genomes to introduce large numbers of unique restriction enzyme recognition sites while preserving wild-type function by substitution of synonymous codons. We show that the resulting problem is NP-Complete, give an exponential-time algorithm, and propose effective heuristics, which we show give excellent results for five sample viral genomes. Our resulting modified genomes have several times more unique restriction sites and reduce the maximum gap between adjacent sites by three to nine-fold.

  13. Do Ramadan fasting restrictions alter eating behaviours?

    PubMed

    Erol, Atila; Baylan, Gonul; Yazici, Fadime

    2008-07-01

    During Ramadan month, Muslims should refrain from drinking, eating and smoking from dawn to sunset. Ramadan fasting can be considered as a kind of dietary restriction. Eating restriction is a risk factor for later development of eating disorders. The purpose of this study is to evaluate whether Ramadan fasting changes the eating behaviours of young people, especially girls who are known as the most vulnerable group for eating disorders. Our sample consisted of 79 healthy volunteers from a high school (63 females; mean age = 16.29; 16 males; mean age = 16.31) who fasted during the Ramadan month. No statistically significant differences were found between the scores of EAT (Eating Attitude Test) and BITE (Bulimic Investigatory Test, Edinburgh) which were administered within the weeks before and after Ramadan. According to our results Ramadan fasting restrictions do not seem to change the eating behaviours of young girls and boys.

  14. Caloric restriction mimetics: towards a molecular definition.

    PubMed

    Madeo, Frank; Pietrocola, Federico; Eisenberg, Tobias; Kroemer, Guido

    2014-10-01

    Caloric restriction, be it constant or intermittent, is reputed to have health-promoting and lifespan-extending effects. Caloric restriction mimetics (CRMs) are compounds that mimic the biochemical and functional effects of caloric restriction. In this Opinion article, we propose a unifying definition of CRMs as compounds that stimulate autophagy by favouring the deacetylation of cellular proteins. This deacetylation process can be achieved by three classes of compounds that deplete acetyl coenzyme A (AcCoA; the sole donor of acetyl groups), that inhibit acetyl transferases (a group of enzymes that acetylate lysine residues in an array of proteins) or that stimulate the activity of deacetylases and hence reverse the action of acetyl transferases. A unifying definition of CRMs will be important for the continued development of this class of therapeutic agents.

  15. The compartmental restriction of cerebellar interneurons

    PubMed Central

    Consalez, G. Giacomo; Hawkes, Richard

    2013-01-01

    The Purkinje cells (PC's) of the cerebellar cortex are subdivided into multiple different molecular phenotypes that form an elaborate array of parasagittal stripes. This array serves as a scaffold around which afferent topography is organized. The ways in which cerebellar interneurons may be restricted by this scaffolding are less well-understood. This review begins with a brief survey of cerebellar topography. Next, it reviews the development of stripes in the cerebellum with a particular emphasis on the embryological origins of cerebellar interneurons. These data serve as a foundation to discuss the hypothesis that cerebellar compartment boundaries also restrict cerebellar interneurons, both excitatory [granule cells, unipolar brush cells (UBCs)] and inhibitory (e.g., Golgi cells, basket cells). Finally, it is proposed that the same PC scaffold that restricts afferent terminal fields to stripes may also act to organize cerebellar interneurons. PMID:23346049

  16. IFITM Proteins Restrict Viral Membrane Hemifusion

    PubMed Central

    Golfetto, Ottavia; Bungart, Brittani; Li, Minghua; Ding, Shilei; He, Yuxian; Liang, Chen; Lee, James C.; Gratton, Enrico; Cohen, Fredric S.; Liu, Shan-Lu

    2013-01-01

    The interferon-inducible transmembrane (IFITM) protein family represents a new class of cellular restriction factors that block early stages of viral replication; the underlying mechanism is currently not known. Here we provide evidence that IFITM proteins restrict membrane fusion induced by representatives of all three classes of viral membrane fusion proteins. IFITM1 profoundly suppressed syncytia formation and cell-cell fusion induced by almost all viral fusion proteins examined; IFITM2 and IFITM3 also strongly inhibited their fusion, with efficiency somewhat dependent on cell types. Furthermore, treatment of cells with IFN also markedly inhibited viral membrane fusion and entry. By using the Jaagsiekte sheep retrovirus envelope and influenza A virus hemagglutinin as models for study, we showed that IFITM-mediated restriction on membrane fusion is not at the steps of receptor- and/or low pH-mediated triggering; instead, the creation of hemifusion was essentially blocked by IFITMs. Chlorpromazine (CPZ), a chemical known to promote the transition from hemifusion to full fusion, was unable to rescue the IFITM-mediated restriction on fusion. In contrast, oleic acid (OA), a lipid analog that generates negative spontaneous curvature and thereby promotes hemifusion, virtually overcame the restriction. To explore the possible effect of IFITM proteins on membrane molecular order and fluidity, we performed fluorescence labeling with Laurdan, in conjunction with two-photon laser scanning and fluorescence-lifetime imaging microscopy (FLIM). We observed that the generalized polarizations (GPs) and fluorescence lifetimes of cell membranes expressing IFITM proteins were greatly enhanced, indicating higher molecularly ordered and less fluidized membranes. Collectively, our data demonstrated that IFITM proteins suppress viral membrane fusion before the creation of hemifusion, and suggested that they may do so by reducing membrane fluidity and conferring a positive spontaneous

  17. Is fluid restriction needed in heart failure?

    PubMed

    Castro-Gutiérrez, Victoria; Rada, Gabriel

    2017-01-09

    Fluid restriction is usually recommended in chronic heart failure. However, the evidence base to support this is not that clear. Searching in Epistemonikos database, which is maintained by screening multiple databases, we identified five systematic reviews evaluating 11 studies addressing the question of this article, including seven randomized trials. We extracted data, combined the evidence using meta-analysis and generated a summary of findings table following the GRADE approach. We concluded fluid restriction probably decreases hospital readmission in chronic heart failure and might decrease mortality, but the certainty of the evidence for the latter is low.

  18. Differentiating constrictive pericarditis from restrictive cardiomyopathy.

    PubMed

    Yazdani, Kambiz; Maraj, Suraj; Amanullah, Aman M

    2005-01-01

    Constrictive pericarditis and restrictive cardiomyopathy are 2 forms of diastolic dysfunction with similar presentation but different treatment options. Whereas constrictive pericarditis has the potential of being cured with pericardiectomy, restrictive cardiomyopathy is usually incurable. It is therefore crucial to differentiate between the 2 disorders. In the last few years, new diagnostic techniques have become available to differentiate these causes of diastolic dysfunction from each other. This review provides a complete, in-depth comparison of the 2 disorders with regard to their symptoms and clinical features, etiology, pathophysiology, hemodynamics, echocardiographic presentation, and finally the different available management options.

  19. Superconductivity in Supersymmetric Theory in Restricted Chromodynamics

    NASA Astrophysics Data System (ADS)

    Rajput, B. S.; Kumar, Sandeep

    2011-02-01

    The study of superconductivity, dual superconductivity and color superconductivity has been undertaken through the breaking of super symmetric gauge theory in restricted chromo dynamics (RCD) which automatically incorporates the condensation of monopoles and dyons leading to confining and superconducting phases. Dyonic supermultiplets in N=1 super symmetry have been obtained quantum mechanically in RCD and it has been shown that dyon appears in RCD theory only through restricted part of the generalized potential and it is only this part of this potential which is responsible for quark confinement and the resulting superconductivity through the mechanism of dyonic condensation.

  20. Counting planar diagrams with various restrictions

    NASA Astrophysics Data System (ADS)

    't Hooft, Gerard

    1999-01-01

    Explicit expressions are considered for the generating functions concerning the number of planar diagrams with given numbers of 3- and 4-point vertices. It is observed that planar renormalization theory requires diagrams with restrictions, in the sense that one wishes to omit 'tadpole' insertions and 'seagull' insertions; at a later stage also self-energy insertions are to be removed, and finally also the dressed 3-point insertions and the dressed 4-point insertions. Diagrams with such restrictions can all be counted exactly. This results in various critical lines in the λ- g plane, where λ and g are effective zero-dimensional coupling constants. These lines can be localized exactly.

  1. Update on Human Calorie Restriction Research123

    PubMed Central

    Roberts, Susan B.; Speakman, John

    2013-01-01

    The United States population is aging rapidly, and understanding the potential impact and feasibility of lifestyle interventions on the aging process is of central importance for addressing future population health and health care costs. This symposium addressed the question of whether caloric restriction may be a feasible strategy to improve human health by reductions in rates of primary and secondary aging in humans, viewed from the perspective of existing data in animal models, and by using emerging data from the human Comprehensive Assessment of Long-Term Reduction in Energy Intake trial, which is a randomized trial of human caloric restriction in free-living men and women. PMID:24038258

  2. 10 CFR 1045.16 - Criteria for evaluation of restricted data and formerly restricted data information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Criteria for evaluation of restricted data and formerly restricted data information. 1045.16 Section 1045.16 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NUCLEAR..., produce nuclear weapons materials, or make other military use of nuclear energy; (4) Whether...

  3. 10 CFR 1045.16 - Criteria for evaluation of restricted data and formerly restricted data information.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Criteria for evaluation of restricted data and formerly restricted data information. 1045.16 Section 1045.16 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NUCLEAR..., produce nuclear weapons materials, or make other military use of nuclear energy; (4) Whether...

  4. 10 CFR 1045.16 - Criteria for evaluation of restricted data and formerly restricted data information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Criteria for evaluation of restricted data and formerly restricted data information. 1045.16 Section 1045.16 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NUCLEAR..., produce nuclear weapons materials, or make other military use of nuclear energy; (4) Whether...

  5. 10 CFR 1045.16 - Criteria for evaluation of restricted data and formerly restricted data information.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Criteria for evaluation of restricted data and formerly restricted data information. 1045.16 Section 1045.16 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NUCLEAR..., produce nuclear weapons materials, or make other military use of nuclear energy; (4) Whether...

  6. 10 CFR 1045.16 - Criteria for evaluation of restricted data and formerly restricted data information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Criteria for evaluation of restricted data and formerly restricted data information. 1045.16 Section 1045.16 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NUCLEAR..., produce nuclear weapons materials, or make other military use of nuclear energy; (4) Whether...

  7. 36 CFR 1260.28 - Who is responsible for declassifying Restricted Data, Formerly Restricted Data, and...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false Who is responsible for declassifying Restricted Data, Formerly Restricted Data, and Transclassified Foreign Nuclear Information? 1260.28 Section 1260.28 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION DECLASSIFICATION DECLASSIFICATION OF NATIONA...

  8. 46 CFR 184.202 - Restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Cooking and Heating § 184.202 Restrictions. (a) The use of gasoline for cooking, heating, or lighting is prohibited on all vessels. (b) Fireplaces or other space heating equipment with open flames are prohibited from being used on all vessels. (c) Vessels permitted...

  9. 46 CFR 184.202 - Restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Cooking and Heating § 184.202 Restrictions. (a) The use of gasoline for cooking, heating, or lighting is prohibited on all vessels. (b) Fireplaces or other space heating equipment with open flames are prohibited from being used on all vessels. (c) Vessels permitted...

  10. 46 CFR 184.202 - Restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Cooking and Heating § 184.202 Restrictions. (a) The use of gasoline for cooking, heating, or lighting is prohibited on all vessels. (b) Fireplaces or other space heating equipment with open flames are prohibited from being used on all vessels. (c) Vessels permitted...

  11. 46 CFR 184.202 - Restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Cooking and Heating § 184.202 Restrictions. (a) The use of gasoline for cooking, heating, or lighting is prohibited on all vessels. (b) Fireplaces or other space heating equipment with open flames are prohibited from being used on all vessels. (c) Vessels permitted...

  12. 46 CFR 184.202 - Restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Cooking and Heating § 184.202 Restrictions. (a) The use of gasoline for cooking, heating, or lighting is prohibited on all vessels. (b) Fireplaces or other space heating equipment with open flames are prohibited from being used on all vessels. (c) Vessels permitted...

  13. 46 CFR 121.202 - Restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... SYSTEMS AND EQUIPMENT Cooking and Heating § 121.202 Restrictions. (a) The use of gasoline for cooking, heating, or lighting is prohibited on all vessels. (b) Fireplaces or other space heating equipment with... § 121.240. The use of these fuels for cooking, heating, and lighting on ferry vessels is prohibited...

  14. 46 CFR 121.202 - Restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SYSTEMS AND EQUIPMENT Cooking and Heating § 121.202 Restrictions. (a) The use of gasoline for cooking, heating, or lighting is prohibited on all vessels. (b) Fireplaces or other space heating equipment with... § 121.240. The use of these fuels for cooking, heating, and lighting on ferry vessels is prohibited...

  15. 45 CFR 3.42 - Restricted activities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Restricted activities. 3.42 Section 3.42 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CONDUCT OF PERSONS AND TRAFFIC ON... contrary to security regulations or Department of Health and Human Services policies, or where...

  16. 47 CFR 64.1200 - Delivery restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 3 2011-10-01 2011-10-01 false Delivery restrictions. 64.1200 Section 64.1200... time the call is made; or (v) Is made by or on behalf of a tax-exempt nonprofit organization. (3) Use a... requirements under paragraph (a)(3)(v) of this section is unlawful; (C) The notice sets forth the requirements...

  17. 47 CFR 64.1200 - Delivery restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 3 2014-10-01 2014-10-01 false Delivery restrictions. 64.1200 Section 64.1200... “business associate,” as those terms are defined in the HIPAA Privacy Rule, 45 CFR 160.103. (3) Initiate any... organizations are not covered by this paragraph (a)(7). (8) Use any technology to dial any telephone number for...

  18. 47 CFR 64.1200 - Delivery restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 3 2012-10-01 2012-10-01 false Delivery restrictions. 64.1200 Section 64.1200... “business associate,” as those terms are defined in the HIPAA Privacy Rule, 45 CFR 160.103. (3) Initiate any... organizations are not covered by this paragraph (a)(7). (8) Use any technology to dial any telephone number for...

  19. 47 CFR 64.1200 - Delivery restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 3 2013-10-01 2013-10-01 false Delivery restrictions. 64.1200 Section 64.1200... “business associate,” as those terms are defined in the HIPAA Privacy Rule, 45 CFR 160.103. (3) Initiate any... organizations are not covered by this paragraph (a)(7). (8) Use any technology to dial any telephone number for...

  20. 50 CFR 665.206 - Gear restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... restrictions. (a) Bottom trawls and bottom set gillnets. Fishing for Hawaii bottomfish and seamount groundfish... established to be fishing for Hawaii bottomfish or seamount groundfish MUS in the management subareas is... substances for the purpose of harvesting Hawaii bottomfish and seamount groundfish MUS is prohibited. ...

  1. 9 CFR 81.3 - General restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., ELK, AND MOOSE § 81.3 General restrictions. No farmed or captive deer, elk, or moose may be moved... Program. The captive deer, elk, or moose is: (1) Enrolled in the CWD Herd Certification Program and the... associated with CWD. (b) Animals captured for interstate movement and release. If the captive deer, elk, or...

  2. 9 CFR 81.3 - General restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., ELK, AND MOOSE § 81.3 General restrictions. No farmed or captive deer, elk, or moose may be moved... Program. The captive deer, elk, or moose is: (1) Enrolled in the CWD Herd Certification Program and: (i...) The farmed or captive deer, elk, or moose is accompanied by a certificate issued in accordance with...

  3. 9 CFR 81.3 - General restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., ELK, AND MOOSE § 81.3 General restrictions. No farmed or captive deer, elk, or moose may be moved... Program. The captive deer, elk, or moose is: (1) Enrolled in the CWD Herd Certification Program and the... associated with CWD. (b) Animals captured for interstate movement and release. If the captive deer, elk, or...

  4. 9 CFR 81.3 - General restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., ELK, AND MOOSE § 81.3 General restrictions. No farmed or captive deer, elk, or moose may be moved... Program. The captive deer, elk, or moose is: (1) Enrolled in the CWD Herd Certification Program and: (i...) The farmed or captive deer, elk, or moose is accompanied by a certificate issued in accordance with...

  5. 9 CFR 81.3 - General restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., ELK, AND MOOSE § 81.3 General restrictions. No farmed or captive deer, elk, or moose may be moved... Program. The captive deer, elk, or moose is: (1) Enrolled in the CWD Herd Certification Program and: (i...) The farmed or captive deer, elk, or moose is accompanied by a certificate issued in accordance with...

  6. 45 CFR 400.44 - Restriction.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT, ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES REFUGEE RESETTLEMENT PROGRAM Immigration Status and Identification of Refugees Documentation of Refugee Status § 400.44 Restriction. An applicant for asylum is...

  7. 45 CFR 400.44 - Restriction.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT, ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES REFUGEE RESETTLEMENT PROGRAM Immigration Status and Identification of Refugees Documentation of Refugee Status § 400.44 Restriction. An applicant for asylum is...

  8. 45 CFR 400.44 - Restriction.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT, ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES REFUGEE RESETTLEMENT PROGRAM Immigration Status and Identification of Refugees Documentation of Refugee Status § 400.44 Restriction. An applicant for asylum is...

  9. 45 CFR 400.44 - Restriction.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT, ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES REFUGEE RESETTLEMENT PROGRAM Immigration Status and Identification of Refugees Documentation of Refugee Status § 400.44 Restriction. An applicant for asylum is...

  10. Neyman's Restricted Chi-Square Tests.

    ERIC Educational Resources Information Center

    Timm, Neil H.

    Pearson's unrestricted chi-square procedure is reviewed, and an historical presentation of Neyman's restricted chi-square test is introduced with a discussion of its theory and applicability to education. An example of the Neyman procedure is discussed in detail to familiarize researchers with this useful technique for analyzing contingency…

  11. 32 CFR 552.55 - Restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Restrictions. 552.55 Section 552.55 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY MILITARY RESERVATIONS AND NATIONAL CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Solicitation on Military Reservations §...

  12. 50 CFR 665.265 - Size restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Size restrictions. The height of a live coral specimen shall be determined by a straight line measurement taken from its base to its most distal extremity. The stem diameter of a living coral specimen... cm) from the top surface of the living holdfast. (a) Live pink coral harvested from any precious...

  13. 50 CFR 665.665 - Size restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Fisheries § 665.665 Size restrictions. The height of a live coral specimen shall be determined by a straight line measurement taken from its base to its most distal extremity. The stem diameter of a living coral... (2.54 cm) from the top surface of the living holdfast. (a) Live pink coral harvested from any...

  14. 50 CFR 665.165 - Size restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... § 665.165 Size restrictions. The height of a live coral specimen shall be determined by a straight line measurement taken from its base to its most distal extremity. The stem diameter of a living coral specimen... cm) from the top surface of the living holdfast. (a) Live pink coral harvested from any precious...

  15. 36 CFR 13.1176 - Speed restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Speed restrictions. 13.1176 Section 13.1176 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Glacier Bay National Park and Preserve...

  16. 36 CFR 13.1182 - Noise restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Noise restrictions. 13.1182 Section 13.1182 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Glacier Bay National Park and Preserve...

  17. 36 CFR 13.1182 - Noise restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Noise restrictions. 13.1182 Section 13.1182 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Glacier Bay National Park and Preserve...

  18. 36 CFR 13.1182 - Noise restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Noise restrictions. 13.1182 Section 13.1182 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Glacier Bay National Park and Preserve...

  19. 36 CFR 13.1182 - Noise restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Noise restrictions. 13.1182 Section 13.1182 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Glacier Bay National Park and Preserve...

  20. 36 CFR 13.1176 - Speed restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Speed restrictions. 13.1176 Section 13.1176 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Glacier Bay National Park and Preserve...

  1. 36 CFR 13.1176 - Speed restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Speed restrictions. 13.1176 Section 13.1176 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Glacier Bay National Park and Preserve...

  2. 36 CFR 13.1182 - Noise restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Noise restrictions. 13.1182 Section 13.1182 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Glacier Bay National Park and Preserve...

  3. 36 CFR 13.1176 - Speed restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Speed restrictions. 13.1176 Section 13.1176 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Glacier Bay National Park and Preserve...

  4. 36 CFR 13.1176 - Speed restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Speed restrictions. 13.1176 Section 13.1176 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Glacier Bay National Park and Preserve...

  5. 40 CFR 258.28 - Liquids restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... MUNICIPAL SOLID WASTE LANDFILLS Operating Criteria § 258.28 Liquids restrictions. (a) Bulk or... (Paint Filter Liquids Test), included in “Test Methods for Evaluating Solid Waste, Physical/Chemical.../code_of_federal_regulations/ibr_locations.html. (2) Gas condensate means the liquid generated as a...

  6. 40 CFR 258.28 - Liquids restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... MUNICIPAL SOLID WASTE LANDFILLS Operating Criteria § 258.28 Liquids restrictions. (a) Bulk or... (Paint Filter Liquids Test), included in “Test Methods for Evaluating Solid Waste, Physical/Chemical.../code_of_federal_regulations/ibr_locations.html. (2) Gas condensate means the liquid generated as a...

  7. 40 CFR 258.28 - Liquids restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... MUNICIPAL SOLID WASTE LANDFILLS Operating Criteria § 258.28 Liquids restrictions. (a) Bulk or... (Paint Filter Liquids Test), included in “Test Methods for Evaluating Solid Waste, Physical/Chemical.../code_of_federal_regulations/ibr_locations.html. (2) Gas condensate means the liquid generated as a...

  8. 40 CFR 258.28 - Liquids restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... MUNICIPAL SOLID WASTE LANDFILLS Operating Criteria § 258.28 Liquids restrictions. (a) Bulk or... (Paint Filter Liquids Test), included in “Test Methods for Evaluating Solid Waste, Physical/Chemical.../code_of_federal_regulations/ibr_locations.html. (2) Gas condensate means the liquid generated as a...

  9. 36 CFR 331.18 - Restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false Restrictions. 331.18 Section 331.18 Parks, Forests, and Public Property CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY REGULATIONS GOVERNING THE PROTECTION, USE AND MANAGEMENT OF THE FALLS OF THE OHIO NATIONAL WILDLIFE CONSERVATION AREA...

  10. 36 CFR 331.18 - Restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false Restrictions. 331.18 Section 331.18 Parks, Forests, and Public Property CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY REGULATIONS GOVERNING THE PROTECTION, USE AND MANAGEMENT OF THE FALLS OF THE OHIO NATIONAL WILDLIFE CONSERVATION AREA...

  11. 36 CFR 331.18 - Restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false Restrictions. 331.18 Section 331.18 Parks, Forests, and Public Property CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY REGULATIONS GOVERNING THE PROTECTION, USE AND MANAGEMENT OF THE FALLS OF THE OHIO NATIONAL WILDLIFE CONSERVATION AREA...

  12. 36 CFR 327.12 - Restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... REGULATIONS GOVERNING PUBLIC USE OF WATER RESOURCE DEVELOPMENT PROJECTS ADMINISTERED BY THE CHIEF OF ENGINEERS... by the District Commander. (f) Unless authorized by the District Commander, smoking is prohibited in Visitor Centers, enclosed park buildings and in areas posted to restrict smoking....

  13. 36 CFR 327.12 - Restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... annoy or endanger persons at any time or exceed state or local laws governing noise levels from... by the District Commander. (f) Unless authorized by the District Commander, smoking is prohibited in Visitor Centers, enclosed park buildings and in areas posted to restrict smoking....

  14. 45 CFR 400.44 - Restriction.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT, ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES REFUGEE RESETTLEMENT PROGRAM Immigration Status and Identification of Refugees Documentation of Refugee Status § 400.44 Restriction. An applicant for asylum is...

  15. REBASE--restriction enzymes and methylases.

    PubMed Central

    Roberts, R J; Macelis, D

    1994-01-01

    REBASE is a comprehensive database of information about restriction enzymes and their associated methylases, including their recognition and cleavage sites and their commercial availability. Information from REBASE is available via monthly electronic mailings as well as via WAIS and anonymous ftp. Specialized files are available that can be used directly by many software packages. PMID:7937073

  16. 42 CFR 2.13 - Confidentiality restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONFIDENTIALITY OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS General Provisions § 2.13 Confidentiality restrictions... place where only alcohol or drug abuse diagnosis, treatment, or referral is provided may be acknowledged... facility if the facility is not publicy identified as only an alcohol or drug abuse diagnosis, treatment or...

  17. 18 CFR 35.39 - Affiliate restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Sales of Electric Energy, Capacity and Ancillary Services at Market-Based Rates § 35.39 Affiliate... the Seller's market-based rate tariff. (b) Restriction on affiliate sales of electric energy or... electric energy or capacity may be made between a franchised public utility with captive customers and...

  18. 18 CFR 35.39 - Affiliate restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Sales of Electric Energy, Capacity and Ancillary Services at Market-Based Rates § 35.39 Affiliate... the Seller's market-based rate tariff. (b) Restriction on affiliate sales of electric energy or... electric energy or capacity may be made between a franchised public utility with captive customers and...

  19. 18 CFR 35.39 - Affiliate restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Sales of Electric Energy, Capacity and Ancillary Services at Market-Based Rates § 35.39 Affiliate... the Seller's market-based rate tariff. (b) Restriction on affiliate sales of electric energy or... electric energy or capacity may be made between a franchised public utility with captive customers and...

  20. 50 CFR 660.511 - Catch restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... § 660.511 Catch restrictions. (a) All CPS harvested shoreward of the outer boundary of the EEZ (0-200... trip limit for harvesting vessels fishing in the CPS Limited Entry Zone for CPS other than live bait without a limited entry permit is 5 mt tons of all CPS finfish combined. (c)The trip limit for...

  1. 50 CFR 660.511 - Catch restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... § 660.511 Catch restrictions. (a) All CPS harvested shoreward of the outer boundary of the EEZ (0-200... trip limit for harvesting vessels fishing in the CPS Limited Entry Zone for CPS other than live bait without a limited entry permit is 5 mt tons of all CPS finfish combined. (c)The trip limit for...

  2. 7 CFR 2500.106 - Funding restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Funding restrictions. 2500.106 Section 2500.106 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF ADVOCACY AND OUTREACH... Outreach and Assistance For Socially Disadvantaged Farmers and Ranchers Program § 2500.106 Funding...

  3. 7 CFR 2500.106 - Funding restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Funding restrictions. 2500.106 Section 2500.106 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF ADVOCACY AND OUTREACH... Outreach and Assistance For Socially Disadvantaged Farmers and Ranchers Program § 2500.106 Funding...

  4. 7 CFR 2500.106 - Funding restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Funding restrictions. 2500.106 Section 2500.106 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF ADVOCACY AND OUTREACH... Outreach and Assistance For Socially Disadvantaged Farmers and Ranchers Program § 2500.106 Funding...

  5. 30 CFR 56.4400 - Use restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Fire Prevention and Control Flammable and Combustible Liquids and Gases § 56.4400 Use restrictions. (a) Flammable liquids...

  6. 30 CFR 56.4400 - Use restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Fire Prevention and Control Flammable and Combustible Liquids and Gases § 56.4400 Use restrictions. (a) Flammable liquids...

  7. 30 CFR 57.4400 - Use restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Fire Prevention and Control Flammable and Combustible Liquids and Gases § 57.4400 Use restrictions. (a) Flammable liquids...

  8. 30 CFR 56.4400 - Use restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Fire Prevention and Control Flammable and Combustible Liquids and Gases § 56.4400 Use restrictions. (a) Flammable liquids...

  9. 30 CFR 57.4400 - Use restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Fire Prevention and Control Flammable and Combustible Liquids and Gases § 57.4400 Use restrictions. (a) Flammable liquids...

  10. 30 CFR 56.4400 - Use restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Fire Prevention and Control Flammable and Combustible Liquids and Gases § 56.4400 Use restrictions. (a) Flammable liquids...

  11. 30 CFR 57.4400 - Use restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Fire Prevention and Control Flammable and Combustible Liquids and Gases § 57.4400 Use restrictions. (a) Flammable liquids...

  12. 30 CFR 57.4400 - Use restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Fire Prevention and Control Flammable and Combustible Liquids and Gases § 57.4400 Use restrictions. (a) Flammable liquids...

  13. 30 CFR 57.4400 - Use restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Fire Prevention and Control Flammable and Combustible Liquids and Gases § 57.4400 Use restrictions. (a) Flammable liquids...

  14. 30 CFR 56.4400 - Use restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Fire Prevention and Control Flammable and Combustible Liquids and Gases § 56.4400 Use restrictions. (a) Flammable liquids...

  15. 40 CFR 1033.740 - Credit restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... credits generated under this part. (b) General cycle restriction. Locomotives subject to both switch cycle standards and line-haul cycle standards (such as Tier 2 locomotives) may generate both switch and line-haul... that is certified to a switch cycle NOX FEL below the applicable switch cycle standard and a...

  16. 9 CFR 166.2 - General restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AGRICULTURE SWINE HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.2 General restrictions. (a) No person shall feed or permit the feeding of garbage to swine unless the garbage is treated to... to the feeding or the permitting of the feeding to swine of garbage only because the garbage consists...

  17. 9 CFR 166.2 - General restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AGRICULTURE SWINE HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.2 General restrictions. (a) No person shall feed or permit the feeding of garbage to swine unless the garbage is treated to... to the feeding or the permitting of the feeding to swine of garbage only because the garbage consists...

  18. 9 CFR 166.2 - General restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AGRICULTURE SWINE HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.2 General restrictions. (a) No person shall feed or permit the feeding of garbage to swine unless the garbage is treated to... to the feeding or the permitting of the feeding to swine of garbage only because the garbage consists...

  19. 9 CFR 166.2 - General restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AGRICULTURE SWINE HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.2 General restrictions. (a) No person shall feed or permit the feeding of garbage to swine unless the garbage is treated to... to the feeding or the permitting of the feeding to swine of garbage only because the garbage consists...

  20. 50 CFR 665.99 - Area restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Area restrictions. 665.99 Section 665.99 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC American Samoa Fisheries § 665.99 Area...

  1. 50 CFR 660.511 - Catch restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Catch restrictions. 660.511 Section 660.511 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES OFF WEST COAST STATES Coastal Pelagics Fisheries...

  2. 50 CFR 660.511 - Catch restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Catch restrictions. 660.511 Section 660.511 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES OFF WEST COAST STATES Coastal Pelagics Fisheries...

  3. 50 CFR 648.142 - Time restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Black Sea Bass Fishery § 648.142 Time restrictions. Link to an amendment published at 76 FR 60636, Sept... subject to the possession limit specified in § 648.145(a), may possess black sea bass from May 22 through....142 Black sea bass specifications. (a) Commercial quota, recreational landing limit, research...

  4. 32 CFR 770.18 - Entry restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... LIMITING PUBLIC ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Submarine Base, Bangor, Silverdale, Washington § 770.18 Entry restrictions. Except for military personnel and civilian employees of the United States in the performance of their official duties, entry upon Naval Submarine Base,...

  5. 32 CFR 770.18 - Entry restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... LIMITING PUBLIC ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Submarine Base, Bangor, Silverdale, Washington § 770.18 Entry restrictions. Except for military personnel and civilian employees of the United States in the performance of their official duties, entry upon Naval Submarine Base,...

  6. 32 CFR 770.18 - Entry restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... LIMITING PUBLIC ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Submarine Base, Bangor, Silverdale, Washington § 770.18 Entry restrictions. Except for military personnel and civilian employees of the United States in the performance of their official duties, entry upon Naval Submarine Base,...

  7. 32 CFR 770.18 - Entry restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... LIMITING PUBLIC ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Submarine Base, Bangor, Silverdale, Washington § 770.18 Entry restrictions. Except for military personnel and civilian employees of the United States in the performance of their official duties, entry upon Naval Submarine Base,...

  8. 32 CFR 770.18 - Entry restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... LIMITING PUBLIC ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Submarine Base, Bangor, Silverdale, Washington § 770.18 Entry restrictions. Except for military personnel and civilian employees of the United States in the performance of their official duties, entry upon Naval Submarine Base,...

  9. 46 CFR 108.193 - Restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Restrictions. 108.193 Section 108.193 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT... solid, close-fitted doors or hatches. (b) No access, vent, or sounding tube from a fuel or oil tank...

  10. 46 CFR 108.193 - Restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Restrictions. 108.193 Section 108.193 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT... solid, close-fitted doors or hatches. (b) No access, vent, or sounding tube from a fuel or oil tank...

  11. 46 CFR 108.193 - Restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Restrictions. 108.193 Section 108.193 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT... solid, close-fitted doors or hatches. (b) No access, vent, or sounding tube from a fuel or oil tank...

  12. 46 CFR 121.202 - Restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SYSTEMS AND EQUIPMENT Cooking and Heating § 121.202 Restrictions. (a) The use of gasoline for cooking... gases as cooking fuels by 46 Code of Federal Regulations (CFR) part 147 must meet the requirements of § 121.240. The use of these fuels for cooking, heating, and lighting on ferry vessels is prohibited by...

  13. 46 CFR 121.202 - Restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... SYSTEMS AND EQUIPMENT Cooking and Heating § 121.202 Restrictions. (a) The use of gasoline for cooking... gases as cooking fuels by 46 Code of Federal Regulations (CFR) part 147 must meet the requirements of § 121.240. The use of these fuels for cooking, heating, and lighting on ferry vessels is prohibited by...

  14. 46 CFR 121.202 - Restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... SYSTEMS AND EQUIPMENT Cooking and Heating § 121.202 Restrictions. (a) The use of gasoline for cooking... gases as cooking fuels by 46 Code of Federal Regulations (CFR) part 147 must meet the requirements of § 121.240. The use of these fuels for cooking, heating, and lighting on ferry vessels is prohibited by...

  15. ISOLATED AND RESTRICTED ENVIRONMENTS. PART II.

    DTIC Science & Technology

    The report summarizes research on factors contributing to the satisfaction of men stationed in isolated or restricted settings. It also presents...supplementary material directly related to these studies. Data was collected in four military installations as well as in several isolated and semi-isolated civilian settings.

  16. 50 CFR 16.3 - General restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... INJURIOUS WILDLIFE Introduction § 16.3 General restrictions. Any importation or transportation of live... into or the transportation of live wildlife or eggs thereof between the continental United States, the... birds (see also §§ 16.32 and 16.33 for other exemptions)....

  17. 50 CFR 16.3 - General restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... INJURIOUS WILDLIFE Introduction § 16.3 General restrictions. Any importation or transportation of live... and welfare of human beings, to the interest of forestry, agriculture, and horticulture, and to the... into or the transportation of live wildlife or eggs thereof between the continental United States,...

  18. Design implications of extremely restricted patterning

    NASA Astrophysics Data System (ADS)

    Vaidyanathan, Kaushik; Liu, Renzhi; Liebmann, Lars; Lai, Kafai; Strojwas, Andzrej J.; Pileggi, Larry

    2014-07-01

    Escalating manufacturing cost and complexity is challenging the premise of affordable scaling. With lithography accounting for a large fraction of wafer costs, researchers are actively exploring several cost-effective alternative lithographic techniques, such as directed self-assembly, self-aligned multiple patterning, etc. However, most of the alternative lithographic techniques are restrictive, and it is important to understand the impact of such pattering restrictions on system-on-chip (SoC) design. To this end, we artificially restricted all layers in a 14 nm process to be pure gratings and observed that the pure gratings approach results in an inefficient SoC design with several process integration concerns. To come up with a technology definition that is mindful of designer requirements, it is essential to undertake a holistic design technology co-optimization (DTCO) considering several SoC design elements, such as standard cell logic, static random access memory bitcells, analog blocks, and physical synthesis. Our DTCO on the IBM 14 nm process with additional 10- and 7-nm node-like pattern restrictions leads us to converge on a set of critical pattern constructs that are required for an efficient and affordable SoC design.

  19. 50 CFR 648.105 - Possession restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... fish boxes having a liquid capacity of 18.2 gal (70 L), or a volume of not more than 4,320 in 3 (2.5 ft... Summer Flounder Fisheries § 648.105 Possession restrictions. (a) Unless otherwise specified pursuant to... that person is the owner or operator of a fishing vessel issued a summer flounder moratorium permit, or...

  20. 50 CFR 654.22 - Gear restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... restrictions. (a) Trap construction requirements. No person fishing for stone crab may transport on the water or fish with any trap which does not meet the following requirements: (1) Each trap must be... by 61 by 61 cm) or 8.0 ft3 (0.23 m3). (3) The throats (entrances) to all wood and plastic traps must...

  1. 9 CFR 83.2 - General restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false General restrictions. 83.2 Section 83.2 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS VIRAL HEMORRHAGIC SEPTICEMIA...

  2. 9 CFR 83.2 - General restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false General restrictions. 83.2 Section 83.2 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS VIRAL HEMORRHAGIC SEPTICEMIA...

  3. 9 CFR 83.2 - General restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false General restrictions. 83.2 Section 83.2 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS VIRAL HEMORRHAGIC SEPTICEMIA...

  4. 9 CFR 83.2 - General restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false General restrictions. 83.2 Section 83.2 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS VIRAL HEMORRHAGIC SEPTICEMIA...

  5. 9 CFR 83.2 - General restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false General restrictions. 83.2 Section 83.2 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS VIRAL HEMORRHAGIC SEPTICEMIA...

  6. 7 CFR 3430.1005 - Funding restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ADMINISTRATIVE PROVISIONS Sun Grant Program § 3430.1005 Funding restrictions. (a) Facility costs. Funds made available under the Sun Grant Program shall not be used for the construction of a new building or facility... NIFA to each of the five Centers and the Subcenter under § 3430.1004 for the Sun Grant Program may be...

  7. 7 CFR 3430.1005 - Funding restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ADMINISTRATIVE PROVISIONS Sun Grant Program § 3430.1005 Funding restrictions. (a) Facility costs. Funds made available under the Sun Grant Program shall not be used for the construction of a new building or facility... NIFA to each of the five Centers and the Subcenter under § 3430.1004 for the Sun Grant Program may be...

  8. 7 CFR 3430.1005 - Funding restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ADMINISTRATIVE PROVISIONS Sun Grant Program § 3430.1005 Funding restrictions. (a) Facility costs. Funds made available under the Sun Grant Program shall not be used for the construction of a new building or facility... NIFA to each of the five Centers and the Subcenter under § 3430.1004 for the Sun Grant Program may be...

  9. 7 CFR 3430.1005 - Funding restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... ADMINISTRATIVE PROVISIONS Sun Grant Program § 3430.1005 Funding restrictions. (a) Facility costs. Funds made available under the Sun Grant Program shall not be used for the construction of a new building or facility... NIFA to each of the five Centers and the Subcenter under § 3430.1004 for the Sun Grant Program may be...

  10. Caloric restriction, metabolic rate, and entropy.

    PubMed

    Demetrius, Lloyd

    2004-09-01

    Caloric restriction increases life span in many types of animals. This article proposes a mechanism for this effect based on the hypothesis that metabolic stability, the capacity of an organism to maintain steady state values of redox couples, is a prime determinant of longevity. We integrate the stability-longevity hypothesis with a molecular model of metabolic activity (quantum metabolism), and an entropic theory of evolutionary change (directionality theory), to propose a proximate mechanism and an evolutionary rationale for aging. The mechanistic features of the new theory of aging are invoked to predict that caloric restriction extends life span by increasing metabolic stability. The evolutionary model is exploited to predict that the large increases in life span under caloric restriction observed in rats, a species with early sexual maturity, narrow reproductive span and large litter size, and hence low entropy, will not hold for primates. We affirm that in the case of humans, a species with late sexual maturity, broad reproductive span and small litter size, and hence high entropy, the response of life span to caloric restriction will be negligible.

  11. Restricting profile function of hedgehog skyrmion

    NASA Astrophysics Data System (ADS)

    Yamashita, Jun; Hirayama, Minoru

    2006-11-01

    The profile function for the hedgehog skyrmion is investigated. After discussing how the form of the profile function is restricted by the field equation, the static energy is numerically calculated. It is found that the profile functions considered here sometimes give the static energy smaller than previous ones.

  12. 14 CFR § 1203.411 - Restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Restrictions. § 1203.411 Section § 1203.411 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY PROGRAM... consent of the originating agency. For purposes of this section, the Department of Defense shall be...

  13. 14 CFR 1203.411 - Restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Restrictions. 1203.411 Section 1203.411 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY PROGRAM Guides for... originating agency. For purposes of this section, the Department of Defense shall be considered one agency. (b...

  14. 14 CFR 1203.411 - Restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Restrictions. 1203.411 Section 1203.411 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY PROGRAM Guides for... originating agency. For purposes of this section, the Department of Defense shall be considered one agency. (b...

  15. 47 CFR 97.121 - Restricted operation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES AMATEUR RADIO SERVICE Station Operation Standards § 97.121 Restricted operation. (a) If the operation of an amateur... characteristics, are used to receive such transmissions, and this fact is made known to the amateur station...

  16. 47 CFR 97.121 - Restricted operation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES AMATEUR RADIO SERVICE Station Operation Standards § 97.121 Restricted operation. (a) If the operation of an amateur... characteristics, are used to receive such transmissions, and this fact is made known to the amateur station...

  17. 47 CFR 97.121 - Restricted operation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES AMATEUR RADIO SERVICE Station Operation Standards § 97.121 Restricted operation. (a) If the operation of an amateur... characteristics, are used to receive such transmissions, and this fact is made known to the amateur station...

  18. 47 CFR 97.121 - Restricted operation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES AMATEUR RADIO SERVICE Station Operation Standards § 97.121 Restricted operation. (a) If the operation of an amateur... characteristics, are used to receive such transmissions, and this fact is made known to the amateur station...

  19. 47 CFR 97.121 - Restricted operation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES AMATEUR RADIO SERVICE Station Operation Standards § 97.121 Restricted operation. (a) If the operation of an amateur... characteristics, are used to receive such transmissions, and this fact is made known to the amateur station...

  20. 9 CFR 166.2 - General restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... any infectious or communicable disease of animals and unless the facility is so constructed that swine... AGRICULTURE SWINE HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.2 General restrictions. (a) No person shall feed or permit the feeding of garbage to swine unless the garbage is treated to...

  1. 50 CFR 665.399 - Area restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Area restrictions. 665.399 Section 665.399 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Mariana Archipelago Fisheries § 665.399...

  2. 50 CFR 665.399 - Area restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Area restrictions. 665.399 Section 665.399 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Mariana Archipelago Fisheries...

  3. 50 CFR 665.465 - Size restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Size restrictions. 665.465 Section 665.465 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Mariana Archipelago Fisheries...

  4. 50 CFR 665.399 - Area restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Area restrictions. 665.399 Section 665.399 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Mariana Archipelago Fisheries...

  5. 50 CFR 665.399 - Area restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Area restrictions. 665.399 Section 665.399 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Mariana Archipelago Fisheries...

  6. 50 CFR 665.465 - Size restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Size restrictions. 665.465 Section 665.465 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Mariana Archipelago Fisheries § 665.465...

  7. 50 CFR 665.399 - Area restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Area restrictions. 665.399 Section 665.399 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Mariana Archipelago Fisheries...

  8. 36 CFR 327.12 - Restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false Restrictions. 327.12 Section 327.12 Parks, Forests, and Public Property CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY RULES AND REGULATIONS GOVERNING PUBLIC USE OF WATER RESOURCE DEVELOPMENT PROJECTS ADMINISTERED BY THE CHIEF OF ENGINEERS...

  9. 14 CFR 1203.411 - Restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Restrictions. 1203.411 Section 1203.411 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY PROGRAM Guides for... President through the National Security Council, classified information originating in one agency may not...

  10. 50 CFR 654.22 - Gear restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... restrictions. (a) Trap construction requirements. No person fishing for stone crab may transport on the water or fish with any trap which does not meet the following requirements: (1) Each trap must be... by 61 by 61 cm) or 8.0 ft3 (0.23 m3). (3) The throats (entrances) to all wood and plastic traps...

  11. Restricting Riesz-Morrey-Hardy potentials

    NASA Astrophysics Data System (ADS)

    Liu, L.; Xiao, J.

    2017-06-01

    To strengthen the weak restriction principle discovered in both [2, Theorem 5.1] for λ = κ and [32, Lemma 2.1] for λ < κ, this paper shows that the Riesz operator Iα of order α maps the Morrey-Hardy space LH p , κ to the Morrey-Radon space Lμq,λ continuously if and only if

  12. Mechanisms of Salmonella Typhi Host Restriction.

    PubMed

    Spanò, Stefania

    2016-01-01

    Salmonella enterica serovar Typhi (S. Typhi) is the cause of typhoid fever, a life-threatening bacterial infection that is very common in the developing world. Recent spread of antimicrobial resistant isolates of S. Typhi makes typhoid fever, a global public health risk. Despite being a common disease, still very little is known about the molecular mechanisms underlying typhoid fever and S. Typhi pathogenesis. In contrast to other Salmonellae, S. Typhi can only infect humans. The molecular bases of this human restriction are mostly unknown. Recent studies identified a novel pathway that contributes to S. Typhi human restriction and is required for killing S. Typhi in macrophages of nonsusceptible species. The small Rab GTPase Rab32 and its guanine nucleotide exchange factor BLOC-3 are the critical components of this pathway. These proteins were already well known as important regulators of intracellular membrane transport. In particular, they are central for the transport of enzymes that synthetize melanin in pigment cells. The recent findings that Rab32 and BLOC-3 are required for S. Typhi host restriction point out to a novel mechanism restricting the growth of bacterial pathogen, dependent on the transport of still unknown molecule(s) to the S. Typhi vacuole. The identification of this novel antimicrobial pathway constitutes a critical starting point to study molecular mechanisms killing bacterial pathogens and possibly identify novel antimicrobial molecules.

  13. 9 CFR 80.2 - General restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false General restrictions. 80.2 Section 80.2 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS JOHNE'S DISEASE IN DOMESTIC...

  14. Nutrigenetics and nutrigenomics of caloric restriction.

    PubMed

    Abete, Itziar; Navas-Carretero, Santiago; Marti, Amelia; Martinez, J Alfredo

    2012-01-01

    Obesity is a complex disease resulting from a chronic and long-term positive energy balance in which both genetic and environmental factors are involved. Weight-reduction methods are mainly focused on dietary changes and increased physical activity. However, responses to nutritional intervention programs show a wide range of interindividual variation, which is importantly influenced by genetic determinants. In this sense, subjects carrying several obesity-related single-nucleotide polymorphisms (SNPs) show differences in the response to calorie-restriction programs. Furthermore, there is evidence indicating that dietary components not only fuel the body but also participate in the modulation of gene expression. Thus, the expression pattern and nutritional regulation of several obesity-related genes have been studied, as well as those that are differentially expressed by caloric restriction. The responses to caloric restriction linked to the presence of SNPs in obesity-related genes are reviewed in this chapter. Also, the influence of energy restriction on gene expression pattern in different tissues is addressed. Copyright © 2012 Elsevier Inc. All rights reserved.

  15. 36 CFR 331.18 - Restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Restrictions. 331.18 Section 331.18 Parks, Forests, and Public Property CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY REGULATIONS GOVERNING THE PROTECTION, USE AND MANAGEMENT OF THE FALLS OF THE OHIO NATIONAL WILDLIFE CONSERVATION AREA...

  16. 40 CFR 1033.740 - Credit restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... credits generated under this part. (b) General cycle restriction. Locomotives subject to both switch cycle standards and line-haul cycle standards (such as Tier 2 locomotives) may generate both switch and line-haul... that is certified to a switch cycle NOX FEL below the applicable switch cycle standard and a...

  17. 36 CFR 327.12 - Restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Restrictions. 327.12 Section 327.12 Parks, Forests, and Public Property CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY RULES AND... may be requested to leave the project. (d) The operation or use of any sound producing or...

  18. 32 CFR 701.44 - Restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 5 2012-07-01 2012-07-01 false Restrictions. 701.44 Section 701.44 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY REGULATIONS AND... costs of the computer central processing unit, input-output devices, and memory capacity equal $24.00...

  19. Restricted Liberty, Parental Choice and Homeschooling

    ERIC Educational Resources Information Center

    Merry, Michael S.; Karsten, Sjoerd

    2010-01-01

    In this paper the authors carefully study the problem of liberty as it applies to school choice, and whether there ought to be restricted liberty in the case of homeschooling. They examine three prominent concerns that might be brought against homeschooling, viz., that it aggravates social inequality, worsens societal conflict and works against…

  20. 45 CFR 3.42 - Restricted activities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Restricted activities. 3.42 Section 3.42 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CONDUCT OF PERSONS AND TRAFFIC ON... contrary to security regulations or Department of Health and Human Services policies, or where...

  1. 45 CFR 3.42 - Restricted activities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Restricted activities. 3.42 Section 3.42 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CONDUCT OF PERSONS AND TRAFFIC ON... contrary to security regulations or Department of Health and Human Services policies, or where...

  2. 45 CFR 3.42 - Restricted activities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Restricted activities. 3.42 Section 3.42 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CONDUCT OF PERSONS AND TRAFFIC ON... contrary to security regulations or Department of Health and Human Services policies, or where...

  3. 45 CFR 3.42 - Restricted activities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Restricted activities. 3.42 Section 3.42 Public Welfare Department of Health and Human Services GENERAL ADMINISTRATION CONDUCT OF PERSONS AND TRAFFIC ON... contrary to security regulations or Department of Health and Human Services policies, or where...

  4. 50 CFR 665.665 - Size restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... § 665.665 Size restrictions. The height of a live coral specimen shall be determined by a straight line measurement taken from its base to its most distal extremity. The stem diameter of a living coral specimen... cm) from the top surface of the living holdfast. (a) Live pink coral harvested from any precious...

  5. 50 CFR 665.265 - Size restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... restrictions. The height of a live coral specimen shall be determined by a straight line measurement taken from its base to its most distal extremity. The stem diameter of a living coral specimen shall be... top surface of the living holdfast. (a) Live pink coral harvested from any precious coral permit area...

  6. 50 CFR 665.165 - Size restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... restrictions. The height of a live coral specimen shall be determined by a straight line measurement taken from its base to its most distal extremity. The stem diameter of a living coral specimen shall be... top surface of the living holdfast. (a) Live pink coral harvested from any precious coral permit area...

  7. Using Restricted Factor Analysis in Test Construction.

    ERIC Educational Resources Information Center

    Oort, Frans J.

    The use of restrictive factor analysis (RFA) is illustrated with data from the field of educational research. An attitude scale measuring the degree to which students feel they are accepted by their classmates is constructed in accordance with the Theory of Violators. The main idea of the Theory of Violators is that most problems associated with…

  8. 12 CFR 1808.623 - Lobbying restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 10 2014-01-01 2014-01-01 false Lobbying restrictions. 1808.623 Section 1808.623 Banks and Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS BOND GUARANTEE PROGRAM Terms and Conditions of Guarantee § 1808...

  9. 9 CFR 92.3 - Movement restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... of Regions Other Than for BSE § 92.3 Movement restrictions. Whenever the European Commission (EC) establishes a quarantine for a disease in the European Union in a region the Animal and Plant Health... the European Union, such animals and animal products are prohibited importation into the United States....

  10. 50 CFR 660.511 - Catch restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Catch restrictions. 660.511 Section 660.511 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES OFF WEST COAST STATES Coastal Pelagics...

  11. 12 CFR 1228.2 - Restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... SECURITY INTERESTS IN, MORTGAGES ON PROPERTIES ENCUMBERED BY CERTAIN PRIVATE TRANSFER FEE COVENANTS AND RELATED SECURITIES § 1228.2 Restrictions. The regulated entities shall not purchase, invest or otherwise deal in any mortgages on properties encumbered by private transfer fee covenants, securities backed by...

  12. 12 CFR 1805.808 - Lobbying restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Lobbying restrictions. 1805.808 Section 1805.808 Banks and Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS PROGRAM Terms and Conditions of Assistance § 1805.808...

  13. 42 CFR 2.13 - Confidentiality restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... only if the patient's written consent is obtained in accordance with subpart C of these regulations or... CONFIDENTIALITY OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS General Provisions § 2.13 Confidentiality restrictions. (a) General. The patient records to which these regulations apply may be disclosed or used only...

  14. 42 CFR 2.13 - Confidentiality restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... only if the patient's written consent is obtained in accordance with subpart C of these regulations or... CONFIDENTIALITY OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS General Provisions § 2.13 Confidentiality restrictions. (a) General. The patient records to which these regulations apply may be disclosed or used only...

  15. 42 CFR 2.13 - Confidentiality restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... only if the patient's written consent is obtained in accordance with subpart C of these regulations or... CONFIDENTIALITY OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS General Provisions § 2.13 Confidentiality restrictions. (a) General. The patient records to which these regulations apply may be disclosed or used only...

  16. 7 CFR 982.50 - Restricted obligation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... merchantable hazelnuts, under paragraph (a)(1) of this section, the equivalent quantity, by weight as... handling a quantity, by weight, of certified merchantable hazelnuts determined by dividing the quantity... restricted percentage; (2) has withheld from handling an equivalent quantity of creditable ungraded inshell...

  17. 7 CFR 982.50 - Restricted obligation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... merchantable hazelnuts, under paragraph (a)(1) of this section, the equivalent quantity, by weight as... handling a quantity, by weight, of certified merchantable hazelnuts determined by dividing the quantity... restricted percentage; (2) has withheld from handling an equivalent quantity of creditable ungraded inshell...

  18. 7 CFR 982.50 - Restricted obligation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... merchantable hazelnuts, under paragraph (a)(1) of this section, the equivalent quantity, by weight as... handling a quantity, by weight, of certified merchantable hazelnuts determined by dividing the quantity... restricted percentage; (2) has withheld from handling an equivalent quantity of creditable ungraded inshell...

  19. 45 CFR 9.5 - Restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Restrictions. 9.5 Section 9.5 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION USE OF HHS RESEARCH FACILITIES BY ACADEMIC... damage to the non-Government user's experiments or equipment. The agreement must also contain a...

  20. 45 CFR 9.5 - Restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Restrictions. 9.5 Section 9.5 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION USE OF HHS RESEARCH FACILITIES BY ACADEMIC... damage to the non-Government user's experiments or equipment. The agreement must also contain a...