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Sample records for 90y bremsstrahlung spect

  1. Development and evaluation of an improved quantitative 90Y bremsstrahlung SPECT method

    PubMed Central

    Rong, Xing; Du, Yong; Ljungberg, Michael; Rault, Erwann; Vandenberghe, Stefaan; Frey, Eric C.

    2012-01-01

    Purpose: Yttrium-90 (90Y) is one of the most commonly used radionuclides in targeted radionuclide therapy (TRT). Since it decays with essentially no gamma photon emissions, surrogate radionuclides (e.g., 111In) or imaging agents (e.g., 99mTc MAA) are typically used for treatment planning. It would, however, be useful to image 90Y directly in order to confirm that the distributions measured with these other radionuclides or agents are the same as for the 90Y labeled agents. As a result, there has been a great deal of interest in quantitative imaging of 90Y bremsstrahlung photons using single photon emission computed tomography (SPECT) imaging. The continuous and broad energy distribution of bremsstrahlung photons, however, imposes substantial challenges on accurate quantification of the activity distribution. The aim of this work was to develop and evaluate an improved quantitative 90Y bremsstrahlung SPECT reconstruction method appropriate for these imaging applications. Methods: Accurate modeling of image degrading factors such as object attenuation and scatter and the collimator-detector response is essential to obtain quantitatively accurate images. All of the image degrading factors are energy dependent. Thus, the authors separated the modeling of the bremsstrahlung photons into multiple categories and energy ranges. To improve the accuracy, the authors used a bremsstrahlung energy spectrum previously estimated from experimental measurements and incorporated a model of the distance between 90Y decay location and bremsstrahlung emission location into the SIMIND code used to generate the response functions and kernels used in the model. This improved Monte Carlo bremsstrahlung simulation was validated by comparison to experimentally measured projection data of a 90Y line source. The authors validated the accuracy of the forward projection model for photons in the various categories and energy ranges using the validated Monte Carlo (MC) simulation method. The

  2. MO-G-17A-06: Kernel Based Dosimetry for 90Y Microsphere Liver Therapy Using 90Y Bremsstrahlung SPECT/CT

    SciTech Connect

    Mikell, J; Siman, W; Kappadath, S; Mahvash, A; Mourtada, F

    2014-06-15

    Purpose: 90Y microsphere therapy in liver presents a situation where beta transport is dominant and the tissue is relatively homogenous. We compare voxel-based absorbed doses from a 90Y kernel to Monte Carlo (MC) using quantitative 90Y bremsstrahlung SPECT/CT as source distribution. Methods: Liver, normal liver, and tumors were delineated by an interventional radiologist using contrast-enhanced CT registered with 90Y SPECT/CT scans for 14 therapies. Right lung was segmented via region growing. The kernel was generated with 1.04 g/cc soft tissue for 4.8 mm voxel matching the SPECT. MC simulation materials included air, lung, soft tissue, and bone with varying densities. We report percent difference between kernel and MC (%Δ(K,MC)) for mean absorbed dose, D70, and V20Gy in total liver, normal liver, tumors, and right lung. We also report %Δ(K,MC) for heterogeneity metrics: coefficient of variation (COV) and D10/D90. The impact of spatial resolution (0, 10, 20 mm FWHM) and lung shunt fraction (LSF) (1,5,10,20%) on the accuracy of MC and kernel doses near the liver-lung interface was modeled in 1D. We report the distance from the interface where errors become <10% of unblurred MC as d10(side of interface, dose calculation, FWHM blurring, LSF). Results: The %Δ(K,MC) for mean, D70, and V20Gy in tumor and liver was <7% while right lung differences varied from 60–90%. The %Δ(K,MC) for COV was <4.8% for tumor and liver and <54% for the right lung. The %Δ(K,MC) for D10/D90 was <5% for 22/23 tumors. d10(liver,MC,10,1–20) awere <9mm and d10(liver,MC,20,1–20) awere <15mm; both agreed within 3mm to the kernel. d10(lung,MC,10,20), d10(lung,MC,10,1), d10(lung,MC,20,20), and d10(lung,MC,20,1) awere 6, 25, 15, and 34mm, respectively. Kernel calculations on blurred distributions in lung had errors > 10%. Conclusions: Liver and tumor voxel doses with 90Y kernel and MC agree within 7%. Large differences exist between the two methods in right lung. Research reported in this

  3. Optimization of energy window for {sup 90}Y bremsstrahlung SPECT imaging for detection tasks using the ideal observer with model-mismatch

    SciTech Connect

    Rong Xing; Ghaly, Michael; Frey, Eric C.

    2013-06-15

    Purpose: In yttrium-90 ({sup 90}Y) microsphere brachytherapy (radioembolization) of unresectable liver cancer, posttherapy {sup 90}Y bremsstrahlung single photon emission computed tomography (SPECT) has been used to document the distribution of microspheres in the patient and to help predict potential side effects. The energy window used during projection acquisition can have a significant effect on image quality. Thus, using an optimal energy window is desirable. However, there has been great variability in the choice of energy window due to the continuous and broad energy distribution of {sup 90}Y bremsstrahlung photons. The area under the receiver operating characteristic curve (AUC) for the ideal observer (IO) is a widely used figure of merit (FOM) for optimizing the imaging system for detection tasks. The IO implicitly assumes a perfect model of the image formation process. However, for {sup 90}Y bremsstrahlung SPECT there can be substantial model-mismatch (i.e., difference between the actual image formation process and the model of it assumed in reconstruction), and the amount of the model-mismatch depends on the energy window. It is thus important to account for the degradation of the observer performance due to model-mismatch in the optimization of the energy window. The purpose of this paper is to optimize the energy window for {sup 90}Y bremsstrahlung SPECT for a detection task while taking into account the effects of the model-mismatch. Methods: An observer, termed the ideal observer with model-mismatch (IO-MM), has been proposed previously to account for the effects of the model-mismatch on IO performance. In this work, the AUC for the IO-MM was used as the FOM for the optimization. To provide a clinically realistic object model and imaging simulation, the authors used a background-known-statistically and signal-known-statistically task. The background was modeled as multiple compartments in the liver with activity parameters independently following a

  4. Monte Carlo simulation of PET and SPECT imaging of {sup 90}Y

    SciTech Connect

    Takahashi, Akihiko Sasaki, Masayuki; Himuro, Kazuhiko; Yamashita, Yasuo; Komiya, Isao; Baba, Shingo

    2015-04-15

    Purpose: Yittrium-90 ({sup 90}Y) is traditionally thought of as a pure beta emitter, and is used in targeted radionuclide therapy, with imaging performed using bremsstrahlung single-photon emission computed tomography (SPECT). However, because {sup 90}Y also emits positrons through internal pair production with a very small branching ratio, positron emission tomography (PET) imaging is also available. Because of the insufficient image quality of {sup 90}Y bremsstrahlung SPECT, PET imaging has been suggested as an alternative. In this paper, the authors present the Monte Carlo-based simulation–reconstruction framework for {sup 90}Y to comprehensively analyze the PET and SPECT imaging techniques and to quantitatively consider the disadvantages associated with them. Methods: Our PET and SPECT simulation modules were developed using Monte Carlo simulation of Electrons and Photons (MCEP), developed by Dr. S. Uehara. PET code (MCEP-PET) generates a sinogram, and reconstructs the tomography image using a time-of-flight ordered subset expectation maximization (TOF-OSEM) algorithm with attenuation compensation. To evaluate MCEP-PET, simulated results of {sup 18}F PET imaging were compared with the experimental results. The results confirmed that MCEP-PET can simulate the experimental results very well. The SPECT code (MCEP-SPECT) models the collimator and NaI detector system, and generates the projection images and projection data. To save the computational time, the authors adopt the prerecorded {sup 90}Y bremsstrahlung photon data calculated by MCEP. The projection data are also reconstructed using the OSEM algorithm. The authors simulated PET and SPECT images of a water phantom containing six hot spheres filled with different concentrations of {sup 90}Y without background activity. The amount of activity was 163 MBq, with an acquisition time of 40 min. Results: The simulated {sup 90}Y-PET image accurately simulated the experimental results. PET image is visually

  5. Evaluation of quantitative planar 90Y bremsstrahlung whole-body imaging

    NASA Astrophysics Data System (ADS)

    Minarik, D.; Ljungberg, M.; Segars, P.; Sjögreen Gleisner, K.

    2009-10-01

    With high-dose administration of 90Y labeled antibodies, it is possible to image 90Y without an admixture of 111In. We have earlier shown that it is possible to perform quantitative 90Y bremsstrahlung SPECT for dosimetry purposes with reasonable accuracy. However, whole-body (WB) activity quantification with the conjugate view method is not as time consuming as SPECT and has been the method of choice for dosimetry. We have investigated the possibility of using a conjugate view method where scatter-, backscatter- and septal-penetration compensations are performed by inverse filtering and attenuation correction is performed with a WB x-ray image, for total-body and organ activity quantification of 90Y. The method was evaluated using both Monte Carlo simulated scintillation camera images using realistic source distributions, and by an experimental phantom study. The method was evaluated in terms of image quality and accuracy of the activity quantification. The experimental phantom study was performed using the RSD torso phantom with 90Y activity uniformly distributed in the liver insert. A GE Discovery VH/Hawkeye system was used to acquire the image. The simulation study was performed for a realistic activity distribution in the NCAT anthropomorphic phantom where 90Y bremsstrahlung images were generated using the SIMIND MC program. Two different phantom configurations and two activity distributions were simulated. To mimic the RSD phantom experiment one simulation study was also made with 90Y activity located only in the liver. The SIMIND program was configured to resemble a GE Discovery VH/Hawkeye system. An x-ray projector program was used to generate whole-body x-ray images from the NCAT phantom for attenuation correction in the conjugate view method. Organ activities were calculated from ROIs that exactly covered the organs. Corrections for background activity, overlapping activity and source extension in the depth direction were applied on the ROI data. The total

  6. Collimator and energy window optimization for ⁹⁰Y bremsstrahlung SPECT imaging: A SIMIND Monte Carlo study.

    PubMed

    Roshan, Hoda Rezaei; Mahmoudian, Babak; Gharepapagh, Esmaeil; Azarm, Ahmadreza; Islamian, Jalil Pirayesh

    2016-02-01

    Treatment efficacy of radioembolization using Yttrium-90 ((90)Y) microspheres is assessed by the (90)Y bremsstrahlung single photon emission computed tomography (SPECT) imaging following radioembolization. The radioisotopic image has the potential of providing reliable activity map of (90)Y microspheres distribution. One of the main reasons of the poor image quality in (90)Y bremsstrahlung SPECT imaging is the continuous and broad energy spectrum of the related bremsstrahlung photons. Furthermore, collimator geometry plays an impressive role in the spatial resolution, sensitivity and image contrast. Due to the relatively poor quality of the (90)Y bremsstrahlung SPECT images, we intend to optimize the medium-energy (ME) parallel-hole collimator and energy window. The Siemens e.cam gamma camera equipped with a ME collimator and a voxelized phantom was simulated by the SImulating Medical Imaging Nuclear Detectors (SIMIND) program. We used the SIMIND Monte Carlo program to generate the (90)Y bremsstrahlung SPECT projection of the digital Jaszczak phantom. The phantom consist of the six hot spheres ranging from 9.5 to 31.8mm in diameter, which are used to evaluate the image contrast. In order to assess the effect of the energy window on the image contrast, three energy windows ranging from 60 to 160 KeV, 160 to 400 KeV, and 60 to 400 KeV were set on a (90)Y bremsstrahlung spectrum. As well, the effect of the hole diameter of a ME collimator on the image contrast and bremsstrahlung spectrum were investigated. For the fixed collimator and septa thickness values (3.28 cm and 1.14 mm, respectively), a hole diameter range (2.35-3.3mm) was chosen based on the appropriate balance between the spatial resolution and sensitivity. The optimal energy window for (90)Y bremsstrahlung SPECT imaging was extended energy window from 60 to 400 KeV. Besides, The optimal value of the hole diameter of ME collimator was obtained 3.3mm. Geometry of the ME parallel-hole collimator and energy

  7. Attenuation of bremsstrahlung from 90Sr-90Y, 147Pm and 204Tl in thick target compounds

    NASA Astrophysics Data System (ADS)

    Manjunatha, H. C.

    2014-11-01

    The external bremsstrahlung (EB) produced by beta particles such as from 90Sr-90Y, 147Pm and 204Tl in PbCl2, PbF2, Pb(NO3)2 and CdO were measured using NaI(Tl) crystal. The beta stopper technique is employed to measure the integral intensities above 100 keV energy in different absorber thicknesses. Attenuation of the external bremsstrahlung, excited by 90Sr-90Y, 147Pm and 204Tl beta-emitters in the same compounds has also been studied. The measured attenuation parameter is not constant with absorber thickness and it increases with increasing Zmod of the absorber. Whereas, the mass attenuation coefficient of gamma rays of equivalent energy is independent of the absorber thickness. This confirms that the attenuation of EB in an absorber does not conform to a single exponential law, unlike the absorption of monoenergetic gamma rays. Rather it may be a combination of a large number of exponential terms.

  8. Production of glass microspheres comprising 90Y and (177)Lu for treating of hepatic tumors with SPECT imaging capabilities.

    PubMed

    Poorbaygi, Hosein; Reza Aghamiri, Seyed Mahmoud; Sheibani, Shahab; Kamali-Asl, Alireza; Mohagheghpoor, Elham

    2011-10-01

    Our objective was to determine if glass microspheres impregnated with two radionuclides, (90)Y as source of therapeutic beta emissions and (177)Lu as source of diagnostic gamma emissions can be useful for SPECT imaging during or after application of the (90)Y microspheres for treating of hepatic tumors. The glass-based microspheres labeled with (89)Y and lutetium (YAS (Lu)) or (89)Y and ytterbium (YAS (Yb)) were prepared by the sol-gel process where sol droplets directly were formed to gel microspheres. Results of the neutron activation indicate that such a combination of glass, microspheres allow bio-distribution studies by SPECT imaging with high resolution. PMID:21723135

  9. Yttrium-90-labeled microsphere tracking during liver selective internal radiotherapy by bremsstrahlung pinhole SPECT: feasibility study and evaluation in an abdominal phantom

    PubMed Central

    2011-01-01

    contrast. This fills the gap between the performance of90Y-PET and bremsstrahlung pinhole SPECT which is a more affordable technique and could even be used during the catheterization procedure in order to optimize the90Y activity to inject. PMID:22214246

  10. PET/CT and Bremsstrahlung Imaging After 90Y DOTANOC Therapy for Rectal Net With Liver Metastases.

    PubMed

    Abdülrezzak, Ümmühan; Kula, Mustafa; Tutuş, Ahmet; Buyukkaya, Fikret; Karaca, Halit

    2015-10-01

    Peptide receptor radionuclide therapy with Lu or Y is promising with successful results in somatostatin receptor-positive tumors. In all radiation therapies, knowledge of the radiation dose received by the target, and other organs in the body is essential to evaluate the risks and benefits of any procedure. We report a case of liver metastases from a rectal neuroendocrine tumor, which was treated with Y DOTANOC. Posttreatment whole-body planar images were acquired through Bremsstrahlung radiations of Y on a γ-camera, and thoracolumbar PET/CT images were acquired on PET. PMID:26204211

  11. Monte Carlo characterization of biocompatible beta-emitting 90Y glass seed incorporated with the radionuclide 153Sm as a SPECT marker for brachytherapy applications.

    PubMed

    Hadadi, Asghar; Sadeghi, Mahdi; Sardari, Dariush; Khanchi, Alireza; Shirazi, Alireza

    2013-01-01

    A glass seed consisting of the β--emitting radionuclide 90Y incorporated with radionuclide 153Sm as SPECT marker is proposed for potential application in brachytherapy in order to reduce the undesirable dose to healthy adjacent organs. The aim of this work is to determine the dosimetric characteristics, as suggested in the AAPM TG-60/TG-149 reports, for this seed using Monte Carlo simulation. Monte Carlo codes MCNP5, EGSnrc, and FLUKA were used to calculate the absorbed dose distribution around the seed. Dosimetric parameters, such as reference absorbed dose rate, radial dose function, and one-dimensional (1D) and two-dimensional (2D) anisotropy functions, were obtained. The computational results from these three codes are in agreement within 5.4% difference on average. The absorbed dose rate at the reference point was estimated to be 5.01 cGy h-1 μCi-1 and self absorption of YAS glass seed amounted to 30.51%. The results showed that, with thermal neutron bombardment of 5 hours in a typical flux, sufficient activity for applications in brachytherapy may be achieved. With a 5 mCi initial activity, the total dose of a YAS glass seed was estimated to be 1.38 Gy at 1.0 cm from the seed center. Comparing with gamma emitting seeds, the 90Y seed could reduce undesirable doses to adjacent organs, because of the rapid dose falloff of beta ray. Because of the high R90 value of 5.5 mm, fewer number of 90Y seeds will be required for an interstitial brachytherapy treatment using permanent implant, in comparison with other beta-emitting seeds. The results would be helpful in the development of the radioactive implants using 90Y glass seeds for the brachytherapy treatment. PMID:24036862

  12. Posttherapy radiation safety considerations in radiomicrosphere treatment with 90Y-microspheres.

    PubMed

    Gulec, Seza A; Siegel, Jeffry A

    2007-12-01

    Radiomicrosphere treatment involves the intrahepatic arterial administration of (90)Y-resin or (90)Y-glass microspheres. The microspheres are biocompatible, but not biodegradable, and little to no (90)Y leaches from the microspheres. Without any bioelimination, the beta-dose delivery is generally confined to the liver. Although U.S. Nuclear Regulatory Commission requirements permit patients treated with these microspheres to be released without the need for dose determination or patient instructions, there are important radiation safety issues that need scientific clarification. We carefully evaluated the radiation exposure mechanisms, including the bremsstrahlung radiation doses to others, for a variety of lifestyle behaviors. Dose estimates were also made for several practical and theoretic situations involving the patient's gonads, an embryo or fetus, and a nursing infant. For the infant, we evaluated the potential beta-dose that might be introduced via breast milk ingestion. The bremsstrahlung component of the decay scheme of the pure beta-emitter (90)Y has traditionally been ignored in internal and external dose calculations. Because the production of in vivo bremsstrahlung with the high-energy pure beta-particle-emitting radionuclides used for therapeutic purposes is sufficient to permit external detection and imaging, we believe that the contribution of such radiation should be considered with regard to patient release; we therefore chose to evaluate this potential external radiation hazard. In all cases, the estimated doses were very small, indicating that no patient restrictions are required for radiation safety purposes after the release of a patient who has been treated with (90)Y-microspheres. PMID:18006608

  13. [Studies of biologic activation associated with molecular receptor increase and tumor response in ChL6/L6 protocol patients; Studies in phantoms; Quantitative SPECT; Preclinical studies; and Clinical studies]. DOE annual report, 1994--95

    SciTech Connect

    DeNardo, S.J.

    1995-12-31

    The authors describe results which have not yet been published from their associated studies listed in the title. For the first, they discuss Lym-1 single chain genetically engineered molecules, analysis of molecular genetic coded messages to enhance tumor response, and human dosimetry and therapeutic human use radiopharmaceuticals. Studies in phantoms includes a discussion of planar image quantitation, counts coincidence correction, organ studies, tumor studies, and {sup 90}Y quantitation with Bremsstrahlung imaging. The study on SPECT discusses attenuation correction and scatter correction. Preclinical studies investigated uptake of {sup 90}Y-BrE-3 in mice using autoradiography. Clinical studies discuss image quantitation verses counts from biopsy samples, S factors for radiation dose calculation, {sup 67}Cu imaging studies for lymphoma cancer, and {sup 111}In MoAb imaging studies for breast cancer to predict {sup 90}Y MoAb therapy.

  14. 3D dosimetry estimation for selective internal radiation therapy (SIRT) using SPECT/CT images: a phantom study

    NASA Astrophysics Data System (ADS)

    Debebe, Senait A.; Franquiz, Juan; McGoron, Anthony J.

    2015-03-01

    Selective Internal Radiation Therapy (SIRT) is a common way to treat liver cancer that cannot be treated surgically. SIRT involves administration of Yttrium - 90 (90Y) microspheres via the hepatic artery after a diagnostic procedure using 99mTechnetium (Tc)-macroaggregated albumin (MAA) to detect extrahepatic shunting to the lung or the gastrointestinal tract. Accurate quantification of radionuclide administered to patients and radiation dose absorbed by different organs is of importance in SIRT. Accurate dosimetry for SIRT allows optimization of dose delivery to the target tumor and may allow for the ability to assess the efficacy of the treatment. In this study, we proposed a method that can efficiently estimate radiation absorbed dose from 90Y bremsstrahlung SPECT/CT images of liver and the surrounding organs. Bremsstrahlung radiation from 90Y was simulated using the Compton window of 99mTc (78keV at 57%). 99mTc images acquired at the photopeak energy window were used as a standard to examine the accuracy of dosimetry prediction by the simulated bremsstrahlung images. A Liqui-Phil abdominal phantom with liver, stomach and two tumor inserts was imaged using a Philips SPECT/CT scanner. The Dose Point Kernel convolution method was used to find the radiation absorbed dose at a voxel level for a three dimensional dose distribution. This method will allow for a complete estimate of the distribution of radiation absorbed dose by tumors, liver, stomach and other surrounding organs at the voxel level. The method provides a quantitative predictive method for SIRT treatment outcome and administered dose response for patients who undergo the treatment.

  15. The role of SPECT/CT in radioembolization of liver tumours.

    PubMed

    Ahmadzadehfar, Hojjat; Duan, Heying; Haug, Alexander R; Walrand, Stephan; Hoffmann, Martha

    2014-05-01

    Radioembolization (RE) with (90)Y microspheres is a promising catheter-based therapeutic option for patients with unresectable primary and metastatic liver tumours. Its rationale arises from the dual blood supply of liver tissue through the hepatic artery and the portal vein. Metastatic hepatic tumours measuring >3 mm derive 80 - 100 % of their blood supply from the arterial rather than the portal hepatic circulation. Typically, an angiographic evaluation combined with (99m)Tc-macroaggregated albumin ((99m)Tc-MAA) scan precedes therapy to map the tumour feeding vessels as well as to avoid the inadvertent deposition of microspheres in organs other than the liver. Prior to administration of (99m)Tc-MAA, prophylactic coil embolization of the gastroduodenal artery is recommended to avoid extrahepatic deposition of the microspheres. SPECT/CT allows direct correlation of anatomic and functional information in patients with unresectable liver disease. SPECT/CT is recommended to assess intrahepatic distribution as well as extrahepatic gastrointestinal uptake in these patients. Pretherapeutic SPECT/CT is an important component of treatment planning including catheter positioning and dose finding. A post-therapy bremsstrahlung (BS) scan should follow RE to verify the distribution of the administered tracer. BS SPECT/CT imaging enables better localization and definition of intrahepatic and possible extrahepatic sphere distribution and to a certain degree allows posttreatment dosimetry. In this paper we address the usefulness and significance of SPECT/CT in therapy planning and therapy monitoring of RE. PMID:24442600

  16. PET optimization for improved assessment and accurate quantification of {sup 90}Y-microsphere biodistribution after radioembolization

    SciTech Connect

    Martí-Climent, Josep M. Prieto, Elena; Elosúa, César; Rodríguez-Fraile, Macarena; Domínguez-Prado, Inés; Vigil, Carmen; García-Velloso, María J.; Arbizu, Javier; Peñuelas, Iván; Richter, José A.

    2014-09-15

    Purpose: {sup 90}Y-microspheres are widely used for the radioembolization of metastatic liver cancer or hepatocellular carcinoma and there is a growing interest for imaging {sup 90}Y-microspheres with PET. The aim of this study is to evaluate the performance of a current generation PET/CT scanner for {sup 90}Y imaging and to optimize the PET protocol to improve the assessment and the quantification of {sup 90}Y-microsphere biodistribution after radioembolization. Methods: Data were acquired on a Biograph mCT-TrueV scanner with time of flight (TOF) and point spread function (PSF) modeling. Spatial resolution was measured with a{sup 90}Y point source. Sensitivity was evaluated using the NEMA 70 cm line source filled with {sup 90}Y. To evaluate the count rate performance, {sup 90}Y vials with activity ranging from 3.64 to 0.035 GBq were measured in the center of the field of view (CFOV). The energy spectrum was evaluated. Image quality with different reconstructions was studied using the Jaszczak phantom containing six hollow spheres (diameters: 31.3, 28.1, 21.8, 16.1, 13.3, and 10.5 mm), filled with a 207 kBq/ml {sup 90}Y concentration and a 5:1 sphere-to-background ratio. Acquisition time was adjusted to simulate the quality of a realistic clinical PET acquisition of a patient treated with SIR-Spheres{sup ®}. The developed methodology was applied to ten patients after SIR-Spheres{sup ®} treatment acquiring a 10 min per bed PET. Results: The energy spectrum showed the{sup 90}Y bremsstrahlung radiation. The {sup 90}Y transverse resolution, with filtered backprojection reconstruction, was 4.5 mm in the CFOV and degraded to 5.0 mm at 10 cm off-axis. {sup 90}Y absolute sensitivity was 0.40 kcps/MBq in the center of the field of view. Tendency of true and random rates as a function of the {sup 90}Y activity could be accurately described using linear and quadratic models, respectively. Phantom studies demonstrated that, due to low count statistics in {sup 90}Y PET

  17. 90Y-labeled monoclonal antibodies for cancer therapy.

    PubMed

    Washburn, L C; Hwa Sun, T T; Crook, J E; Byrd, B L; Carlton, J E; Hung, Y W; Steplewski, Z S

    1986-01-01

    Monoclonal antibody 17-1A, which has specificity for colorectal carcinoma, was labeled with 90Y (10-20% radiolabeling yield). Tissue distribution studies in tumor-bearing nude mice were carried out. 90Y-labeled 17-1A showed good uptake in the SW 948 colon carcinoma cell line. However, 90Y-labeled A5C3, a monoclonal antihepatitis virus antibody studied as a control, showed similar uptake in this tumor. Neither antibody was taken up well by a WM-9 melanoma. It is believed that the loss of specificity observed is due to the low specific activity of the 90Y-labeled monoclonal antibody preparations used. This hypothesis is supported by radioimmunoassay data. PMID:3793501

  18. 90Y labeled phosphorodiamidate morpholino oligomer for pretargeting radiotherapy.

    PubMed

    Liu, Guozheng; Dou, Shuping; Liu, Yuxia; Wang, Yuzhen; Rusckowski, Mary; Hnatowich, Donald J

    2011-12-21

    While (188)Re has been used successfully in mice for tumor radiotherapy by MORF/cMORF pretargeting, previous radiolabeling of the amine-derivatized cMORF with (90)Y, a longer physical half-life nuclide, was not very successful. After developing a method involving a prepurification heating step during conjugation that increases labeling efficiency and label stability, the biodistribution of (90)Y-DOTA-Bn-SCN-cMORF ((90)Y-DOTA-cMORF) was measured in normal mice and in MORF-CC49 pretargeted mice that bear LS174T tumors. Absorbed radiation doses were then estimated and compared to those estimated for (188)Re. The pharmacokinetics of the (90)Y-DOTA-cMORF in normal mice and in the pretargeted nude mice was similar to that observed previously with (99m)Tc- and (188)Re-MAG(3)-cMORFs. While the (90)Y-DOTA-cMORF cleared rapidly from normal tissues, tumor clearance was very slow and tumor radioactivity accumulation was constant for at least 7 days such that the tumor/blood (T/B) ratio increased linearly from 6 to 25 over this period. Therefore, by extrapolation, normal tissue toxicities following administration of therapeutic doses of (90)Y may be comparable to that observed for (188)Re in which the T/B increased from 5 to 20. In conclusion, radiolabeling of DOTA-cMORF with (90)Y was improved by introducing a prepurification heating step during conjugation. The (90)Y-DOTA-cMORF provided a similar T/B ratio and biodistribution to that of (188)Re-MAG(3)-cMORF and was retained well in the tumor pretargeted with MORF-CC49. Because of the longer physical half-life, the T/NT absorbed radiation dose ratios were improved in most organs and especially in blood. PMID:21985267

  19. A 90Y labeled phosphorodiamidate morpholino oligomer for pretargeting radiotherapy

    PubMed Central

    Liu, Guozheng; Dou, Shuping; Liu, Yuxia; Wang, Yuzhen; Rusckowski, Mary; Hnatowich, Donald J

    2011-01-01

    While 188Re has been used successfully in mice for tumor radiotherapy by MORF/cMORF pretargeting, previous radiolabeling of the 18 mer amine-derivatized cMORF with 90Y, a longer physical half life nuclide, was not very successful. After developing a method involving a pre-purification heating step during conjugation that increases labeling efficiency and label stability, the biodistribution of 90Y-DOTA-Bn-SCN-cMORF was measured in normal mice and in MORF-CC49 pretargeted mice that bear LS174T tumors. Absorbed radiation doses were then estimated and compared to those estimated for 188Re. The pharmacokinetics of the 90Y-DOTA-cMORF in normal mice and in the pretargeted nude mice was similar to that observed previously with 99mTc- and 188Re-MAG3-cMORFs. While the 90Y-DOTA-cMORF cleared rapidly from normal tissues, tumor clearance was very slow and tumor radioactivity accumulation was constant for at least 7 days such that the tumor/blood (T/B) ratio increased linearly from 6 to 25 over this period. Therefore by extrapolation, normal tissue toxicities following administration of therapeutic doses of 90Y may be comparable to that observed for 188Re in which the T/B increased from 5 to 20. In conclusion, radiolabeling of DOTA-cMORF with 90Y was improved by introducing a prepurification heating step during conjugation. The 90Y-DOTA-cMORF provided a similar T/B ratio and biodistribution to that of 188Re-MAG3-cMORF and retained well in the tumor pretargeted with MORF-CC49. Because of the longer physical half life, the T/NT absorbed radiation dose ratios were improved in most organs and especially in blood. PMID:21985267

  20. PET/CT-Based Dosimetry in 90Y-Microsphere Selective Internal Radiation Therapy: Single Cohort Comparison With Pretreatment Planning on 99mTc-MAA Imaging and Correlation With Treatment Efficacy

    PubMed Central

    Song, Yoo Sung; Paeng, Jin Chul; Kim, Hyo-Cheol; Chung, Jin Wook; Cheon, Gi Jeong; Chung, June-Key; Lee, Dong Soo; Kang, Keon Wook

    2015-01-01

    Abstract 90Y PET/CT can be acquired after 90Y-microsphere selective radiation internal therapy (SIRT) to describe radioactivity distribution. We performed dosimetry using 90Y-microsphere PET/CT data to evaluate treatment efficacy and appropriateness of activity planning from 99mTc-MAA scan and SPECT/CT. Twenty-three patients with liver malignancy were included in the study. 99mTc-MAA was injected during planning angiography and whole body 99mTc-MAA scan and liver SPECT/CT were acquired. After SIRT using 90Y-resin microsphere, 90Y-microsphere PET/CT was acquired. A partition model (PM) using 4 compartments (tumor, intarget normal liver, out-target normal liver, and lung) was adopted, and absorbed dose to each compartment was calculated based on measurements from 99mTc-MAA SPECT/CT and 90Y-microsphere PET/CT, respectively, to be compared with each other. Progression-free survival (PFS) was evaluated in terms of tumor absorbed doses calculated by 99mTc-MAA SPECT/CT and 90Y-microsphere PET/CT results. Lung shunt fraction was overestimated on 99mTc-MAA scan compared with 90Y-microsphere PET/CT (0.060 ± 0.037 vs. 0.018 ± 0.026, P < 0.01). Tumor absorbed dose exhibited a close correlation between the results from 99mTc-MAA SPECT/CT and 90Y-microsphere PET/CT (r = 0.64, P < 0.01), although the result from 99mTc-MAA SPECT/CT was significantly lower than that from 90Y-microsphere PET/CT (135.4 ± 64.2 Gy vs. 185.0 ± 87.8 Gy, P < 0.01). Absorbed dose to in-target normal liver was overestimated on 99mTc-MAA SPECT/CT compared with PET/CT (62.6 ± 38.2 Gy vs. 45.2 ± 32.0 Gy, P = 0.02). Absorbed dose to out-target normal liver did not differ between 99mTc-MAA SPECT/CT and 90Y-microsphere PET/CT (P = 0.49). Patients with tumor absorbed dose >200 Gy on 90Y-microsphere PET/CT had longer PFS than those with tumor absorbed dose ≤200 Gy (286 ± 56 days vs. 92 ± 20 days, P = 0.046). Tumor absorbed dose calculated by 99m

  1. Selecting patients for treatment with 90Y ibritumomab tiuxetan (Zevalin).

    PubMed

    Gregory, Stephanie A

    2003-12-01

    Yttrium 90 ibritumomab tiuxetan (Zevalin; Biogen Idec Inc, Cambridge, MA) was the first radioimmunotherapeutic agent approved by the US Food and Drug Administration. It is indicated for treating patients with relapsed or refractory low-grade, follicular, or transformed B-cell non-Hodgkin's lymphoma, including patients with rituximab-refractory follicular non-Hodgkin's lymphoma. Proper patient selection is essential for optimizing the efficacy and safety of treatment with (90)Y ibritumomab tiuxetan. It may be advisable to use (90)Y ibritumomab tiuxetan relatively early in a patient's course of treatment because overall and complete response rates, and the estimated median duration of response, are higher among patients who have had fewer median prior antineoplastic regimens than among those who have had a greater median number of such regimens. Furthermore, the myeloablative effect of multiple courses of chemotherapy can preclude the later use of (90)Y ibritumomab tiuxetan. In contrast, other therapies, including chemotherapy and rituximab, can be used safely and successfully after (90)Y ibritumomab tiuxetan without concerns about increased hematologic toxicity from the previous radioimmunotherapy. The main adverse event associated with (90)Y ibritumomab tiuxetan therapy is hematologic toxicity and, as a result, only patients with adequate bone marrow reserves and less than 25% lymphoma marrow involvement should currently be considered for clinical therapy. PMID:14710399

  2. 90 Y-ibritumomab tiuxetan: a nearly forgotten opportunity

    PubMed Central

    Mondello, Patrizia; Cuzzocrea, Salvatore; Navarra, Michele; Mian, Michael

    2016-01-01

    Y-ibritumomab tiuxetan (90Y-IT) combines the benefits of a monoclonal antibody with the efficacy of radiation in the treatment of B-cell non-Hodgkin lymphoma (NHL), a remarkably radiosensitive hematologic malignancy. 90Y-IT activity has been well established in the indolent setting, being approved in front-line treatment of follicular lymphoma (FL) patients as well as salvage therapy. However, no advantage in OS was observed with respect to standard treatment. Promising data are available also for aggressive B-cell lymphoma. In particular, the addition of RIT to short-course first line chemotherapy enables reduction of chemotherapy while maintaining cure rates in elderly, untreated diffuse large B-cell lymphoma (DLBCL) patients. Furthermore, 90Y-IT improves response rate and outcomes of relapsed/refractory DLBCL patients, eligible and ineligible for autologous stem cell transplantation (ASCT). Clinical results have shown a role of 90Y-IT even in mantle cell lymphoma (MCL). RIT might improve responses and treat minimal residual disease when used as consolidation after first-line chemotherapy in MCL. Moreover, 90Y-IT has demonstrated its efficacy in combination with high-dose chemotherapies as conditioning regimen for ASCT, with evidence suggesting the ability to overcome chemotherapy resistance. Herein, we review the available evidence for this approved drug and examine the recently published and ongoing trials for potential novel indication in aggressive B-cell NHL. PMID:26657116

  3. 90 Y-ibritumomab tiuxetan: a nearly forgotten opportunityr.

    PubMed

    Mondello, Patrizia; Cuzzocrea, Salvatore; Navarra, Michele; Mian, Michael

    2016-02-16

    Y-ibritumomab tiuxetan (90Y-IT) combines the benefits of a monoclonal antibody with the efficacy of radiation in the treatment of B-cell non-Hodgkin lymphoma (NHL), a remarkably radiosensitive hematologic malignancy. 90Y-IT activity has been well established in the indolent setting, being approved in front-line treatment of follicular lymphoma (FL) patients as well as salvage therapy. However, no advantage in OS was observed with respect to standard treatment. Promising data are available also for aggressive B-cell lymphoma. In particular, the addition of RIT to short-course first line chemotherapy enables reduction of chemotherapy while maintaining cure rates in elderly, untreated diffuse large B-cell lymphoma (DLBCL) patients. Furthermore, 90Y-IT improves response rate and outcomes of relapsed/refractory DLBCL patients, eligible and ineligible for autologous stem cell transplantation (ASCT). Clinical results have shown a role of 90Y-IT even in mantle cell lymphoma (MCL). RIT might improve responses and treat minimal residual disease when used as consolidation after first-line chemotherapy in MCL. Moreover, 90Y-IT has demonstrated its efficacy in combination with high-dose chemotherapies as conditioning regimen for ASCT, with evidence suggesting the ability to overcome chemotherapy resistance. Herein, we review the available evidence for this approved drug and examine the recently published and ongoing trials for potential novel indication in aggressive B-cell NHL. PMID:26657116

  4. Monte Carlo dosimetry of a new 90Y brachytherapy source

    PubMed Central

    Junxiang, Wu; Shihu, You; Jing, Huang; Fengxiang, Long; Chengkai, Wang; Zhangwen, Wu; Qing, Hou

    2015-01-01

    Purpose In this study, we attempted to obtain full dosimetric data for a new 90Y brachytherapy source developed by the College of Chemistry (Sichuan University) for use in high-dose-rate after-loading systems. Material and methods The dosimetric data for this new source were used as required by the dose calculation formalisms proposed by the AAPM Task Group 60 and Task Group 149. The active core length of the new 90Y source was increased to 4.7 mm compared to the value of 2.5 mm for the old 90Sr/90Y source. The Monte Carlo simulation toolkit Geant4 was used to calculate these parameters. The source was located in a 30-cm-radius theoretical sphere water phantom. Results The dosimetric data included the reference absorbed dose rate, the radial dose function in the range of 1.0 to 8.0 mm in the longitudinal axis, and the anisotropy function with a θ in the range of 0° to 90° at 5° intervals and an r in the range of 1.0 to 8.0 mm in 0.2-mm intervals. The reference absorbed dose rate for the new 90Y source was determined to be equal to 1.6608 ± 0.0008 cGy s–1 mCi–1, compared to the values of 0.9063 ± 0.0005 cGy s–1 mCi–1 that were calculated for the old 90Sr/90Y source. A polynomial function was also obtained for the radial dose function by curve fitting. Conclusions Dosimetric data are provided for the new 90Y brachytherapy source. These data are meant to be used commercially in after-loading system. PMID:26622247

  5. Preparation & in vitro evaluation of 90Y-DOTA-rituximab

    PubMed Central

    Kameswaran, Mythili; Pandey, Usha; Dash, Ashutosh; Samuel, Grace; Venkatesh, Meera

    2016-01-01

    Background & objectives: Radioimmunotherapy is extensively being used for the treatment of non-Hodgkin's lymphoma (NHL). Use of rituximab, a chimeric anti-CD20 antibody directed against the CD20 antigen in combination with suitable beta emitters is expected to result in good treatment response by its cross-fire and bystander effects. The present work involves the conjugation of p-isothiocyanatobenzyl DOTA (p-SCN-Bn-DOTA) to rituximab, its radiolabelling with 90Y and in vitro and in vivo evaluation to determine its potential as a radioimmunotherapeutic agent. Methods: Rituximab was conjugated with p-SCN-Bn-DOTA at 1:1 antibody: DOTA molar ratio. The number of DOTA molecules linked to one molecule of rituximab was determined by radioassay and spectroscopic assay. Radiolabelling of rituximab with 90Y was carried out and its in vitro stability was evaluated. In vitro cell binding studies were carried out in Raji cells expressing CD20 antigen. Biodistribution studies were carried out in normal Swiss mice. Results: Using both radioassay and spectroscopic method, it was determined that about five molecules of DOTA were linked to rituximab. Radiolabelling of the rituximab conjugate with 90Y and subsequent purification on PD-10 column gave a product with radiochemical purity (RCP) > 98 per cent which was retained at > 90 per cent up to 72 h when stored at 37°C. In vitro cell binding experiments of 90Y-DOTA-rituximab with Raji cells exhibited specific binding of 20.7 ± 0.1 per cent with 90Y-DOTA-rituximab which reduced to 15.5 ± 0.2 per cent when incubated with cold rituximab. The equilibrium constant Kd for 90Y-DOTA-Rituximab was determined to be 3.38 nM. Radiolabelled antibody showed clearance via hepatobiliary and renal routes and activity in tibia was found to be quite low indicating in vivo stability of 90Y-DOTA-rituximab. Interpretation & conclusions: p-SCN-Bn-DOTA was conjugated with rituximab and radiolabelling with 90Y was carried out. In vitro studies carried

  6. Prediction of tumor response to experimental radioimmunotherapy with {sup 90}Y in nude mice

    SciTech Connect

    Dillehay, L.E.; Mayer, R.; Zhang, Y.G.

    1995-09-30

    The purpose of this investigation was to identify those factors that predict variability in tumor response to {sup 90}Y-radioimmunotherapy based on measurement of incorporated activity and physical dimensions of individual tumors and to apply the concept of effective dose to radioimmunotherapy. Human colon carcinoma xenografts growing in nude mice were treated with anti-CEA antibodies labeled with {sup 90}Y directly or through a bispecific antibody/labeled hapten system. Tumor response was measured as the delay in growth to eight times the treatment volume. Noninvasive activity (based on bremsstrahlung radiation) and dimension measurements were made in these animals at several times after label injection. The following parameters were compared for their ability to predict individual tumor response: (a) injected activity, (b) injected activity times a factor based on average uptake as a function of volume, (c) in vivo activity per volume measured in each animal at a single time, (d) the integral over time of in vivo activity per volume in each animal, and (e) the minimum dose for each animal in a uniformly active ellipsoid whose total activity and dimensions varied over time the same as the tumor. After correcting for differences in injected activity, two parameters account for much of the variability in tumor response. One of these is the general trend of larger tumors to take up less activity per volume. Additional variability can be accounted for by the in vivo activity per volume measurements. The minimum dose as introduced here is likely to be useful in estimating the biologically effective dose delivered by each treatment. 27 refs., 5 figs., 1 tab.

  7. A computational tool for patient specific dosimetry and radiobiological modeling of selective internal radiation therapy with (90)Y microspheres.

    PubMed

    Kalantzis, Georgios; Leventouri, Theodora; Apte, Aditiya; Shang, Charles

    2015-11-01

    In recent years we have witnessed tremendous progress in selective internal radiation therapy. In clinical practice, quite often, radionuclide therapy is planned using simple models based on standard activity values or activity administered per unit body weight or surface area in spite of the admission that radiation-dose methods provide more accurate dosimetric results. To address that issue, the authors developed a Matlab-based computational software, named Patient Specific Yttrium-90 Dosimetry Toolkit (PSYDT). PSYDT was designed for patient specific voxel-based dosimetric calculations and radiobiological modeling of selective internal radiation therapy with (90)Y microspheres. The developed toolkit is composed of three dimensional dose calculations for both bremsstrahlung and beta emissions. Subsequently, radiobiological modeling is performed on a per-voxel basis and cumulative dose volume histograms (DVHs) are generated. In this report we describe the functionality and visualization features of PSYDT. PMID:26296058

  8. 90Y-Edotreotide for Metastatic Carcinoid Refractory to Octreotide

    PubMed Central

    Bushnell, David L.; O'Dorisio, Thomas M.; O'Dorisio, M. Sue; Menda, Yusuf; Hicks, Rodney J.; Van Cutsem, Eric; Baulieu, Jean-Louis; Borson-Chazot, Francoise; Anthony, Lowell; Benson, Al B.; Oberg, Kjell; Grossman, Ashley B.; Connolly, Mary; Bouterfa, Hakim; Li, Yong; Kacena, Katherine A.; LaFrance, Norman; Pauwels, Stanislas A.

    2010-01-01

    Purpose Metastatic carcinoid is an incurable malignancy whose symptoms, such as diarrhea and flushing, can be debilitating and occasionally life-threatening. Although symptom relief is available with octreotide, the disease eventually becomes refractory to octreotide, leaving no proven treatment options. The goal of this study was to evaluate the clinical effect of using 90Y-edotreotide to treat symptomatic patients with carcinoid tumors. Patients and Methods Patients enrolled had metastatic carcinoid, at least one sign/symptom refractory to octreotide, and at least one measurable lesion. Study treatment consisted of three cycles of 4.4 GBq (120 mCi) 90Y-edotreotide each, once every 6 weeks. Results Ninety patients were enrolled in the study. Using Southwest Oncology Group tumor response criteria, 67 (74.%) of 90 patients (95% CI, 65.4% to 83.4%) were objectively stable or responded. A statistically significant linear trend toward improvement was demonstrated across all 12 symptoms assessed. Median progression-free survival was significantly greater (P = .03) for the 38 patients who had durable diarrhea improvement than the 18 patients who did not (18.2 v 7.9 months, respectively). Adverse events (AEs) were reported in 96.7% (87 of 90) of patients. These AEs consisted primarily of reversible GI events (76 of 90), which could be caused in part by concomitant administration of amino acid solution given to reduce radiation exposure to the kidneys. There was one case each of grade 3 oliguria and grade 4 renal failure, each lasting 6 days. Conclusion 90Y-edotreotide treatment improved symptoms associated with malignant carcinoid among subjects with no treatment alternatives. Treatment was well-tolerated and had an acceptable expected AE profile. PMID:20194865

  9. Resin {sup 90}Y microsphere activity measurements for liver brachytherapy

    SciTech Connect

    Dezarn, William A.; Kennedy, Andrew S.

    2007-06-15

    The measurement of the radioactivity administered to the patient is one of the major components of {sup 90}Y microsphere liver brachytherapy. The activity of {sup 90}Y microspheres in a glass delivery vial was measured in a dose calibrator. The calibration value to use for {sup 90}Y in the dose calibrator was verified using an activity calibration standard provided by the microsphere manufacturer. This method allowed for the determination of a consistent, reproducible local activity standard. Additional measurements were made to determine some of the factors that could affect activity measurement. The axial response of the dose calibrator was determined by the ratio of activity measurements at the bottom and center of the dose calibrator. The axial response was 0.964 for a glass shipping vial, 1.001 for a glass V-vial, and 0.988 for a polycarbonate V-vial. Comparisons between activity measurements in the dose calibrator and those using a radiation survey meter were found to agree within 10%. It was determined that the dose calibrator method was superior to the survey meter method because the former allowed better defined measurement geometry and traceability of the activity standard back to the manufacturer. Part of the preparation of resin {sup 90}Y microspheres for patient delivery is to draw out a predetermined activity from a shipping vial and place it into a V-vial for delivery to the patient. If the drawn activity was placed in a glass V-vial, the activity measured in the dose calibrator with a glass V-vial was 4% higher than the drawn activity from the shipping vial standard. If the drawn activity was placed in a polycarbonate V-vial, the activity measured in the dose calibrator with a polycarbonate V-vial activity was 20% higher than the drawn activity from the shipping vial standard. Careful characterization of the local activity measurement standard is recommended instead of simply accepting the calibration value of the dose calibrator manufacturer.

  10. Three dosimetry models of lipoma arborescens treated by {sup 90}Y synovectomy

    SciTech Connect

    O’Doherty, Jim; Clauss, Ralf; Scuffham, James; Khan, Aman; Petitguillaume, Alice; Desbrée, Aurélie

    2014-05-15

    Purpose: Lipoma arborescens (LA) is a benign intra-articular lipomatous proliferation of the synovial membrane. This extremely rare condition has previously been treated by intra-articular{sup 90}Y radiosynoviorthesis but dosimetry literature on this form of radionuclide therapy is nonexistent. The authors detail methodology for successful treatment of LA and provide for the first time estimates of radiation dosimetry. The authors also analyze the biodistribution of the radiopharmaceutical over the course of the patient's treatment through sequential imaging. Methods: A patient with bilateral LA underwent intracavity injection of{sup 90}Y citrate colloid to the right and left knee joint spaces (181 and 198 MBq, respectively). SPECT/CT datasets were acquired over 9 days to quantify the biodistribution and kinetics of the radiopharmaceutical. Radiation dosimetry was performed using the MIRD schema (through OLINDA software), a custom voxel-based method, and a direct Monte Carlo calculation (OEDIPE). Results: Follow-up MRI showed marked reduction in LA size in both knees. Mean absorbed doses to the LA were 21.2 ± 0.8 and 42.9 ± 2.3 Gy using OLINDA, 8.1 ± 0.3 and 16.7 ± 0.5 Gy using voxel based methodology, and 8.2 ± 0.3 and 15.7 ± 0.5 Gy for OEDIPE in the right and left LA, respectively. Distribution of the radiopharmaceutical within the joint space alters over the imaging period, with less than 1% of the remaining activity having moved posteriorly in the knee cavity. No uptake was detected outside of the joint space after assessment with whole-body scintigraphy. Conclusions: An activity of approximately 185 MBq successfully relieved clinical symptoms of LA. There was good correlation between direct Monte Carlo and voxel based techniques, but OLINDA was shown to overestimate the absorbed dose to the tumor. Accurate dosimetry may help select an activity more tailored to the specific size and location of the LA.

  11. Inverse problem for Bremsstrahlung radiation

    SciTech Connect

    Voss, K.E.; Fisch, N.J.

    1991-10-01

    For certain predominantly one-dimensional distribution functions, an analytic inversion has been found which yields the velocity distribution of superthermal electrons given their Bremsstrahlung radiation. 5 refs.

  12. Hanford isotope project strategic business analysis yttrium-90 (Y-90)

    SciTech Connect

    1995-10-01

    The purpose of this analysis is to address the short-term direction for the Hanford yttrium-90 (Y-90) project. Hanford is the sole DOE producer of Y-90, and is the largest repository for its source in this country. The production of Y-90 is part of the DOE Isotope Production and Distribution (IP and D) mission. The Y-90 is ``milked`` from strontium-90 (Sr-90), a byproduct of the previous Hanford missions. The use of Sr-90 to produce Y-90 could help reduce the amount of waste material processed and the related costs incurred by the clean-up mission, while providing medical and economic benefits. The cost of producing Y-90 is being subsidized by DOE-IP and D due to its use for research, and resultant low production level. It is possible that the sales of Y-90 could produce full cost recovery within two to three years, at two curies per week. Preliminary projections place the demand at between 20,000 and 50,000 curies per year within the next ten years, assuming FDA approval of one or more of the current therapies now in clinical trials. This level of production would incentivize private firms to commercialize the operation, and allow the government to recover some of its sunk costs. There are a number of potential barriers to the success of the Y-90 project, outside the control of the Hanford Site. The key issues include: efficacy, Food and Drug Administration (FDA) approval and medical community acceptance. There are at least three other sources for Y-90 available to the US users, but they appear to have limited resources to produce the isotope. Several companies have communicated interest in entering into agreements with Hanford for the processing and distribution of Y-90, including some of the major pharmaceutical firms in this country.

  13. Survival after somatostatin based radiopeptide therapy with 90Y-DOTATOC vs. 90Y-DOTATOC plus 177Lu-DOTATOC in metastasized gastrinoma

    PubMed Central

    Dumont, Rebecca A; Seiler, Daniela; Marincek, Nicolas; Brunner, Philippe; Radojewski, Piotr; Rochlitz, Christoph; Müller-Brand, Jan; Maecke, Helmut R; Briel, Matthias; Walter, Martin A

    2015-01-01

    We aimed to explore the effects of 90Y-DOTATOC and 90Y-DOTATOC plus 177Lu-DOTATOC on survival of patients with metastasized gastrinoma. Patients with progressive metastasized gastrinoma were treated with repeated cycles of 90Y-DOTATOC or with cycles alternating between 90Y-DOTATOC and 177Lu-DOTATOC until tumor progression or permanent toxicity. Multivariable Cox regression analyses were used to study predictors of survival. A total of 36 patients were enrolled; 30 patients received 90Y-DOTATOC (median activity per patient 11.8GBq; range: 6.1-62.2GBq) and 6 patients received 90Y-DOTATOC plus 177Lu-DOTATOC (median activity per patient: 14.8GBq; range: 7.4-14.8GBq). Response was found in 26 patients (72.2%), including morphological (n=12, 33.3%), biochemical (n=14, 38.9%) and/or clinical response (n=6, 16.2%). A total of 21 patients (58.3%) experienced hematotoxicity grade 1/2, while 1 patient (2.8%) experienced hematotoxicity grade 3; no grade 4 hematotoxicity occurred. Furthermore, 2 patients (5.6%) developed grade 4 renal toxicity; no grade 5 renal toxicity occurred. Responders had a significantly longer median survival from time of enrollment than non-responders (45.1 months, range: 37.1-53.1 months vs. 12.6 months, range: 11.0-14.2, hazard ratio: 0.12 (0.027-0.52), p=0.005). Additionally, there was a trend towards longer median survival with 90Y-DOTATOC plus 177Lu-DOTATOC as compared to 90Y-DOTATOC alone (60.2 months, range: 19.8-100.6 months vs. 27.0 months, range: 4.0-50.0, hazard ratio: 0.21 (0.01-3.98), p=0.16). Response to 90Y-DOTATOC and 90Y-DOTATOC plus 177Lu-DOTATOC therapy is associated with a longer survival in patients with metastasized gastrinoma. Both treatment regimens are promising tools for management of progressive gastrinoma. PMID:25625026

  14. Kidney Dosimetry in 177Lu and 90Y Peptide Receptor Radionuclide Therapy: Influence of Image Timing, Time-Activity Integration Method, and Risk Factors

    PubMed Central

    Guerriero, F.; Ferrari, M. E.; Botta, F.; Fioroni, F.; Grassi, E.; Versari, A.; Sarnelli, A.; Pacilio, M.; Amato, E.; Strigari, L.; Bodei, L.; Paganelli, G.; Iori, M.; Pedroli, G.; Cremonesi, M.

    2013-01-01

    Kidney dosimetry in 177Lu and 90Y PRRT requires 3 to 6 whole-body/SPECT scans to extrapolate the peptide kinetics, and it is considered time and resource consuming. We investigated the most adequate timing for imaging and time-activity interpolating curve, as well as the performance of a simplified dosimetry, by means of just 1-2 scans. Finally the influence of risk factors and of the peptide (DOTATOC versus DOTATATE) is considered. 28 patients treated at first cycle with 177Lu DOTATATE and 30 with 177Lu DOTATOC underwent SPECT scans at 2 and 6 hours, 1, 2, and 3 days after the radiopharmaceutical injection. Dose was calculated with our simplified method, as well as the ones most used in the clinic, that is, trapezoids, monoexponential, and biexponential functions. The same was done skipping the 6 h and the 3 d points. We found that data should be collected until 100 h for 177Lu therapy and 70 h for 90Y therapy, otherwise the dose calculation is strongly influenced by the curve interpolating the data and should be carefully chosen. Risk factors (hypertension, diabetes) cause a rather statistically significant 20% increase in dose (t-test, P < 0.10), with DOTATATE affecting an increase of 25% compared to DOTATOC (t-test, P < 0.05). PMID:23865075

  15. Bremsstrahlung Measurements at PBFA Z

    NASA Astrophysics Data System (ADS)

    Rochau, G. A.; Derzon, M. S.; Fehl, D.; Mock, R.; Ruiz, C.; Sweeney, M. A.; Struve, K.; Lazier, S.; Cooper, G.

    1997-11-01

    The PBFA Z accelerator at Sandia National Laboratories demonstrates z-pinch implosions capable of producing 1.8 MJ of soft x-rays. Associated with the power flow on PBFA Z is a bremsstrahlung background produced by electrons with endpoint energies greater than 2 MeV. In this presentation we present time-integrated images of the bremsstrahlung source, the measured bremsstrahlung spectrum both on-axis and side-on with respect to the target, and the bremsstrahlung background intensity as a function of azimuthal angle over the target. Measurements indicate that this background may be isotropic making it less of a concern when fielding diagnostics than previously considered. Additionally, electron losses, which have critical effects on power flow, are estimated with the Screamer circuit code and compared to the losses as determined by unfolding the measured bremsstrahlung field. Disagreements between these estimates are presented and discussed.

  16. 90Sr content in 90Y-labeled SIR-spheres and Zevalin.

    PubMed

    Metyko, John; Erwin, William; Poston, John; Jimenez, Sandra

    2014-11-01

    Three different 90Y internally administered radionuclide therapies are currently used in both standard-of-care and clinical trial procedures atMD Anderson Cancer Center. TheraSphere and SIR-Spheres therapies utilize 90Y-labeled microspheres, while Zevalin is an 90Y-labeled radioimmunotherapeutic agent. Several publications have indicated radionuclidic impurities resulting from 90Y production methods. The 90Y in SIR-Spheres and Zevalin are produced from a 90Sr/90Y generator, which leaves measurable quantities of 90Sr in the final product. TheraSphere 90Y is produced in a nuclear reactor which results in a large number of impurities, most notably 88Y and 91Y. Product information sheets reference these impurities with specific limits given. These limits represent a tiny fraction of the total product activity, and in the case of TheraSphere and SIR-Spheres gamma-emitting impurities, this has been verified in the literature. An analysis of 90Sr impurities in SIR-Spheres and Zevalin is presented in this paper. Impurity quantities were found to be within the vendors’ documented limits. PMID:25272027

  17. Peptide receptor radionuclide therapy with 90Y-DOTATATE/90Y-DOTATOC in patients with progressive metastatic neuroendocrine tumours: assessment of response, survival and toxicity

    PubMed Central

    Vinjamuri, S; Gilbert, T M; Banks, M; McKane, G; Maltby, P; Poston, G; Weissman, H; Palmer, D H; Vora, J; Pritchard, D M; Cuthbertson, D J

    2013-01-01

    Background: Peptide receptor radionuclide therapy (PRRT) is an established treatment for patients with metastatic neuroendocrine tumours (NETs), although which factors are associated with an improved overall survival (OS) remains unclear. The primary aim of this study is to determine to what extent a radiological response to 90Y-DOTATOC/90Y-DOTATATE PRRT is associated with an improved OS. The association of biochemical and clinical response to OS were assessed as secondary outcome measures. Methods: A retrospective analysis was conducted on 57 patients: radiological response was classified using RECIST criteria, biochemical response was classified using WHO criteria and clinical response was assessed subjectively. Responses were recorded as positive response (PR), stable disease (SD) or progressive disease (PD), and survival analysed. Results: Radiological response was achieved in 71.5% (24.5% PR, 47% SD) and was associated with a greater OS (51 and 56 months, respectively), compared with PD (18 months). A biochemical or clinical response post PRRT were not associated with a statistically significant improvement in OS. However, when combined with radiological response a survival benefit was observed according to the number of outcomes (radiological, biochemical, clinical), in which a response was observed. Mild haematological toxicity was common, renal toxicity was rare. Conclusion: In patients with progressive metastatic NETs receiving 90Y-DOTATOC/90Y-DOTATATE PRRT, a radiological response with either a PR or a SD post therapy confers a significant OS benefit. PMID:23492685

  18. Radioembolization and the Dynamic Role of 90Y PET/CT

    PubMed Central

    Pasciak, Alexander S.; Bourgeois, Austin C.; McKinney, J. Mark; Chang, Ted T.; Osborne, Dustin R.; Acuff, Shelley N.; Bradley, Yong C.

    2014-01-01

    Before the advent of tomographic imaging, it was postulated that decay of 90 Y to the 0+ excited state of 90Zr may result in emission of a positron–electron pair. While the branching ratio for pair-production is small (~32 × 10−6), PET has been successfully used to image 90 Y in numerous recent patients and phantom studies. 90 Y PET imaging has been performed on a variety of PET/CT systems, with and without time-of-flight (TOF) and/or resolution recovery capabilities as well as on both bismuth-germanate and lutetium yttrium orthosilicate (LYSO)-based scanners. On all systems, resolution and contrast superior to bremsstrahlung SPECT has been reported. The intrinsic radioactivity present in LYSO-based PET scanners is a potential limitation associated with accurate quantification of 90 Y. However, intrinsic radioactivity has been shown to have a negligible effect at the high activity concentrations common in 90 Y radioembolization. Accurate quantification is possible on a variety of PET scanner models, with or without TOF, although TOF improves accuracy at lower activity concentrations. Quantitative 90 Y PET images can be transformed into 3-dimensional (3D) maps of absorbed dose based on the premise that the 90 Y activity distribution does not change after infusion. This transformation has been accomplished in several ways, although the most common is with the use of 3D dose-point-kernel convolution. From a clinical standpoint, 90 Y PET provides a superior post-infusion evaluation of treatment technical success owing to its improved resolution. Absorbed dose maps generated from quantitative PET data can be used to predict treatment efficacy and manage patient follow-up. For patients who receive multiple treatments, this information can also be used to provide patient-specific treatment-planning for successive therapies, potentially improving response. The broad utilization of 90 Y PET has the potential to provide a wealth of dose

  19. Evaluation of carrier added and no carrier added 90Y-EDTMP as bone seeking therapeutic radiopharmaceutical.

    PubMed

    Khalid, Muhammad; Bokhari, Tanveer Hussain; Ahmad, Mushtaq; Bhatti, Haq Nawaz; Iqbal, Munawar; Ghaffar, Abdul; Qadir, Muhammad Imran

    2014-07-01

    The optimum conditions to label ethylenediaminetetramethylene phosphonate (EDTMP) compound with (90)y as a potential candidate for bone metastases therapy were investigated. Yttrium-90 is a pure β-emitter and can be obtained by (89)y (n,γ) (90)y nuclear reaction in a reactor or from an in-house generator system ((90)sr(90)y). The preparation of (90)Y-EDTMPis described using (90)y, which was obtained from neutron irradiation of y2o3 as well as from a laboratory scale organic resin-based (90)sr--(90)y generator. Because of the radiolabeling yield of 90Y-EDTMP on ligand/metal molar ratio, incubation time and ph was evaluated. Under optimum parameters, the radiolabeling yields of (90)Y-EDTMP were <95% for no-carrier-added as well as carrier-added (90)y. The biodistribution of no-carrier-added and carrier-added (90)Y-EDTMP complexes in rats was identical. The results indicate that (90)y (carrier-added)-edtmp is also an effective bone pain palliation agent because of its rapid blood clearance, greater uptake in bones and little absorption in soft tissues. PMID:25015445

  20. Administered activity and outcomes of glass versus resin 90Y microsphere radioembolization in patients with colorectal liver metastases

    PubMed Central

    Nasr, Elie C.; Kunam, Vamsi K.; Bullen, Jennifer A.; Purysko, Andrei S.

    2016-01-01

    Background Given the differences in size, specific activity, and dosing methods for glass yttrium-90 microspheres (90Y-glass) and resin 90Y microspheres (90Y-resin), these therapies may expose the liver to different amounts of radiation, thereby affecting their efficacy and tolerability. We aimed to compare the prescribed activity of 90Y-glass and 90Y-resin for real-world patients undergoing selective internal radiation therapy (SIRT) for liver-dominant metastatic colorectal cancer (mCRC) and to assess efficacy and safety outcomes in these patients. Methods We examined the records of 28 consecutive patients with unresectable colorectal liver metastases treated with SIRT between June 2008 and May 2011 at our institution. Using baseline CT and MR images, we calculated a projected activity as if we had used the other product and compared it to the actual prescribed activity of 90Y-glass and 90Y-resin for each SIRT treatment per manufacturer guidelines. Progression and adverse events were evaluated at follow up visits. Survival was analyzed by the Kaplan-Meier method. Results For 90Y-glass treatments with a mean prescribed 90Y activity of 1.77 GBq, the mean projected 90Y-resin activity was 0.84 GBq. For 90Y-resin treatments with a mean prescribed 90Y activity of 1.05 GBq, the mean projected 90Y-glass activity was 2.48 GBq. The median survival was 9.3 months versus 18.2 months for 90Y-glass and 90Y-resin, respectively (P=0.292). During the second year after SIRT, the hazard ratio of death for patients treated with 90Y-glass versus 90Y-resin was 4.0 (95% CI: 1.3, 12.3; P=0.017). No significant difference in progression, adverse events or liver toxicity was observed. Conclusions Using manufacturer recommended guidelines, 90Y-resin delivers significantly less activity than 90Y-glass to patients with liver-dominant mCRC undergoing SIRT with no significant difference in adverse events and a trend toward improved survival. PMID:27563442

  1. Adaptive SPECT

    PubMed Central

    Barrett, Harrison H.; Furenlid, Lars R.; Freed, Melanie; Hesterman, Jacob Y.; Kupinski, Matthew A.; Clarkson, Eric; Whitaker, Meredith K.

    2008-01-01

    Adaptive imaging systems alter their data-acquisition configuration or protocol in response to the image information received. An adaptive pinhole single-photon emission computed tomography (SPECT) system might acquire an initial scout image to obtain preliminary information about the radiotracer distribution and then adjust the configuration or sizes of the pinholes, the magnifications, or the projection angles in order to improve performance. This paper briefly describes two small-animal SPECT systems that allow this flexibility and then presents a framework for evaluating adaptive systems in general, and adaptive SPECT systems in particular. The evaluation is in terms of the performance of linear observers on detection or estimation tasks. Expressions are derived for the ideal linear (Hotelling) observer and the ideal linear (Wiener) estimator with adaptive imaging. Detailed expressions for the performance figures of merit are given, and possible adaptation rules are discussed. PMID:18541485

  2. Use of 90Y-ibritumomab tiuxetan in non-Hodgkin's lymphoma.

    PubMed

    Marcus, Robert

    2005-02-01

    The increase in the incidence of non-Hodgkin's lymphoma (NHL) that has occurred over recent decades is expected to continue. Therapeutic options for patients with NHL have improved over the past 20 years, but almost all patients with low-grade lymphoma and approximately 50% of patients with high-grade lymphoma eventually die of their disease, regardless of the regimen used. Thus, there is a continuing need for novel therapeutic options. One such strategy is targeted radioimmunotherapy, which is an attractive approach because lymphoma cells are inherently sensitive to radiation. 90 Y-ibritumomab tiuxetan (Zevalin; Biogen Idec Inc, San Diego, CA, and Schering AG, Berlin, Germany) was the first radioimmunotherapy agent to be approved by the US Food and Drug Administration for the treatment of patients with relapsed, low-grade B-cell NHL. 90Y-ibritumomab tiuxetan comprises the murine IgG1 anti-CD20 antibody ibritumomab, covalently linked to the beta-emitter 90 Y by a chelator tiuxetan. A prospective trial comparing 90Y-ibritumomab tiuxetan with single-agent rituximab showed an overall response rate (ORR) to 90Y-ibritumomab tiuxetan of 80% (34% complete response [CR]/unconfirmed CR [CRu]) compared with 56% (20% CR/CRu) with rituximab (P = .002). Of patients achieving a CR/CRu, 32% were still in remission at 3 to 4 years of follow-up. Similar efficacy (83% ORR, 43% CR/CRu) has been reported with 90 Y-ibritumomab tiuxetan in patients with relapsed or refractory low-grade NHL with mild thrombocytopenia (platelet counts 100,000 to 149,000/mm3 ), and in patients with rituximab-refractory NHL (ORR 74% [CR 15%] compared with an ORR 32% to last rituximab treatment). Safety data compiled from patients entered into five studies have confirmed initial observations that the toxicities encountered with 90Y-ibritumomab tiuxetan therapy are mainly hematologic and transient. As part of a consolidated clinical approach to the ongoing development of 90Y-ibritumomab tiuxetan, studies are

  3. Inverse Bremsstrahlung in Shocked Astrophysical Plasmas

    NASA Technical Reports Server (NTRS)

    Baring, Matthew G.; Jones, Frank C.; Ellison, Donald C.

    2000-01-01

    There has recently been interest in the role of inverse bremsstrahlung, the emission of photons by fast suprathermal ions in collisions with ambient electrons possessing relatively low velocities, in tenuous plasmas in various astrophysical contexts. This follows a long hiatus in the application of suprathermal ion bremsstrahlung to astrophysical models since the early 1970s. The potential importance of inverse bremsstrahlung relative to normal bremsstrahlung, i.e. where ions are at rest, hinges upon the underlying velocity distributions of the interacting species. In this paper, we identify the conditions under which the inverse bremsstrahlung emissivity is significant relative to that for normal bremsstrahlung in shocked astrophysical plasmas. We determine that, since both observational and theoretical evidence favors electron temperatures almost comparable to, and certainly not very deficient relative to proton temperatures in shocked plasmas, these environments generally render inverse bremsstrahlung at best a minor contributor to the overall emission. Hence inverse bremsstrahlung can be safely neglected in most models invoking shock acceleration in discrete sources such as supernova remnants. However, on scales approximately > 100 pc distant from these sources, Coulomb collisional losses can deplete the cosmic ray electrons, rendering inverse bremsstrahlung, and perhaps bremsstrahlung from knock-on electrons, possibly detectable.

  4. [sup 90]Y-labeled antibody uptake by human tumor xenografts and the effect of systemic administration of EDTA

    SciTech Connect

    Rowlinson-Busza, G.; Snook, D.; Epenetos, A.A. )

    1994-03-30

    A human tumor xenograft model was used to compare the tumor and normal tissue uptake of a tumor-associated monoclonal antibody radiolabeled with [sup 125]I or [sup 90]Y. Nude mice bearing SC xenografts of the human colon adenocarcinoma, HT29, were injected with a mixture of [sup 125]I- and [sup 90]Y-DTPA-labeled AUA1 monoclonal antibody, which recognizes an antigen expressed on the surface of the tumor cells. In addition, the effect of systemic ethylenediaminetetraacetic acid (EDTA) administration on [sup 90]Y-labeled antibody clearance, tumor uptake of antibody and bone accumulation of [sup 90]Y was studied in a nude mouse model of intraperitoneal cancer. Both the absolute amount (%id[center dot]g[sup -1]) and the tumor:normal tissue ratios were superior for the [sup 90]Y-labeled antibody, compared with the iodinated antibody, with the notable exception of bone. These results suggest that [sup 90]Y is a preferable isotope to iodine for radioimmunotherapy of solid masses, but that myelotoxicity due to bone uptake of released [sup 90]Y will limit the radiation dose which can be given when DTPA is used to chelate the [sup 90]Y. The [sup 90]Y-labeled antibody showed similar serum stability in vitro in the presence or absence of EDTA after incubation for up to 48 h. In vivo, urine excretion of [sup 90]Y was significantly enhanced in mice receiving daily injections of 20 mg EDTA for 3 days, commencing 2 h after intraperitoneal antibody administration, compared with control mice. There was no significant difference in the tumor uptake of [sup 90]Y-labeled antibody in EDTA-treated and control mice at any time-point up to 9 days postinjection. However, the bone levels of [sup 90]Y were significantly reduced in EDTA-treated mice at all times from 1 to 9 days. Based on these results, it should be possible to increase the amount of [sup 90]Y-labeled antibody administered, by chelating the released [sup 90]Y with systemic EDTA to facilitate its excretion. 50 refs., 5 figs.

  5. Attenuation of external Bremsstrahlung in metallic absorbers

    SciTech Connect

    Dhaliwal, A.S.; Powar, M.S.; Singh, M. )

    1990-12-01

    In this paper attenuation of bremsstrahlung from {sup 147}Pm and {sup 170}Tm beta emitters has been studied in aluminum, copper, tin, and lead metallic absorbers. Bremsstrahlung spectra and mass attenuation coefficients for monoenergetic gamma rays are used to calculate theoretical attenuation curves. Magnetic deflection and beta stopping techniques are used to measure the integral bremsstrahlung intensities above 30 keV in different target thicknesses. Comparison of measured and calculated attenuation curves shows a good agreement for various absorbers, thus providing a test of this technique, which may be useful in understanding bremsstrahlung intensity buildup and in the design of optimum shielding for bremsstrahlung sources. It is found that the absorption of bremsstrahlung in metallic absorbers does not obey an exponential law and that absorbers act as energy filters.

  6. Comparison of (90)Y activity measurements in nuclear medicine in Germany.

    PubMed

    Kossert, Karsten; Bokeloh, Karen; Ehlers, Marion; Nähle, Ole; Scheibe, Olaf; Schwarz, Uwe; Thieme, Klaus

    2016-03-01

    In 2014, PTB and the company Eckert & Ziegler organized a national comparison exercise to determine the activity of a (90)Y solution. One aim of the comparison was to assess the measurement capability of hospitals and medical practices in Germany. P6-type vials were filled with aliquots of a radioactive (90)Y solution and then sent to 19 participants who were asked to measure the activity in the ampoules as well as in their own standard geometry using syringes. Most of the submitted results have a deviation of less than ±10% from the PTB reference activity when measured in the P6-type vials. The spread is somewhat larger when measured in a syringe geometry. The comparison revealed that some participants have difficulties in applying decay corrections and only a few participants were capable of estimating realistic measurement uncertainties. PMID:26597654

  7. Disproof of solar influence on the decay rates of 90Sr/90 Y

    NASA Astrophysics Data System (ADS)

    Kossert, Karsten; Nähle, Ole J.

    2015-09-01

    A custom-built liquid scintillation counter was used for long-term measurements of 90Sr/90 Y sources. The detector system is equipped with an automated sample changer and three photomultiplier tubes, which makes the application of the triple-to-double coincidence ratio (TDCR) method possible. After decay correction, the measured decay rates were found to be stable and no annual oscillation could be observed. Thus, the findings of this work are in strong contradiction to those of Parkhomov (2011) who reported on annual oscillations when measuring 90Sr/90 Y with a Geiger-Müller counter. Sturrock et al. (2012) carried out a more detailed analysis of the experimental data from Parkhomov and claimed to have found correlations between the decay rates and processes inside the Sun. These findings are questionable, since they are based on inappropriate experimental data as is demonstrated in this work. A frequency analysis of our activity data does not show any significant periodicity.

  8. A Comparison of Techniques for 90Y PET/CT Image-Based Dosimetry Following Radioembolization with Resin Microspheres

    PubMed Central

    Pasciak, Alexander S.; Bourgeois, Austin C.; Bradley, Yong C.

    2014-01-01

    90Y PET/CT following radioembolization has recently been established as a viable diagnostic tool, capable of producing images that are both quantitative and have superior image quality than alternative 90Y imaging modalities. Because radioembolization is assumed to be a permanent implant, it is possible to convert quantitative 90Y PET image sets into data representative of spatial committed absorbed-dose. Multiple authors have performed this transformation using dose-point kernel (DPK) convolution to account for the transport of the high-energy 90Y β-particles. This article explores a technique called the Local Deposition Method (LDM), an alternative to DPK convolution for 90Y image-based dosimetry. The LDM assumes that the kinetic energy from each 90Y β-particle is deposited locally, within the voxel where the decay occurred. Using the combined analysis of phantoms scanned using 90Y PET/CT and ideal mathematical phantoms, an accuracy comparison of DPK convolution and the LDM has been performed. Based on the presented analysis, DPK convolution provides no detectible accuracy benefit over the LDM for 90Y PET-based dosimetry. For PET systems with 90Y resolution poorer than 3.25 mm at full-width and half-max using a small voxel size, the LDM may produce a dosimetric solution that is more accurate than DPK convolution under ideal conditions; however, image noise can obscure some of the perceived benefit. As voxel size increases and resolution decreases, differences between the LDM and DPK convolution are reduced. The LDM method of post-radioembolization dosimetry has the advantage of not requiring additional post-processing. The provided conversion factors can be used to determine committed absorbed-dose using conventional PET image analysis tools. The LDM is a recommended option for routine post-radioembolization 90Y dosimetry based on PET/CT imaging. PMID:24904832

  9. (90) Y/(177) Lu-labelled Cetuximab immunoconjugates: radiochemistry optimization to clinical dose formulation.

    PubMed

    Chakravarty, Rubel; Chakraborty, Sudipta; Sarma, Haladhar Dev; Nair, K V Vimalnath; Rajeswari, Ardhi; Dash, Ashutosh

    2016-07-01

    Radiolabelled monoclonal antibodies (mAbs) are increasingly being utilized in cancer theranostics, which is a significant move toward tailored treatment for individual patients. Cetuximab is a recombinant, human-mouse chimeric IgG1 mAb that binds to the epidermal growth factor receptor with high affinity. We have optimized a protocol for formulation of clinically relevant doses (~2.22 GBq) of (90) Y-labelled Cetuximab and (177) Lu-labelled Cetuximab by conjugation of the mAb with a suitable bifunctional chelator, N-[(R)-2-amino-3-(paraisothiocyanato-phenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N″,N″-pentaacetic acid (CHX-A″-DTPA). The radioimmunoconjugates demonstrated reasonably high specific activity (1.26 ± 0.27 GBq/mg for (90) Y-CHX-A″-DTPA-Cetuximab and 1.14 ± 0.15 GBq/mg for (177) Lu-CHX-A″-DTPA-Cetuximab), high radiochemical purity (>95%) and appreciable in vitro stability under physiological conditions. Preliminary biodistribution studies with both (90) Y-CHX-A″-DTPA-Cetuximab and (177) Lu-CHX-A″-DTPA-Cetuximab in Swiss mice bearing fibrosarcoma tumours demonstrated significant tumour uptake at 24-h post-injection (p.i.) (~16%ID/g) with good tumour-to-background contrast. The results of the biodistribution studies were further corroborated by ex vivo Cerenkov luminescence imaging after administration of (90) Y-CHX-A″-DTPA-Cetuximab in tumour-bearing mice. The tumour uptake at 24 h p.i. was significantly reduced with excess unlabelled Cetuximab, suggesting that the uptake was receptor mediated. The results of this study hold promise, and this strategy should be further explored for clinical translation. PMID:27264196

  10. Multimodality imaging following 90Y radioembolization: a comprehensive review and pictorial essay.

    PubMed

    Atassi, Bassel; Bangash, Affaan K; Bahrani, Ammar; Pizzi, Giuseppi; Lewandowski, Robert J; Ryu, Robert K; Sato, Kent T; Gates, Vanessa L; Mulcahy, Mary F; Kulik, Laura; Miller, Frank; Yaghmai, Vahid; Murthy, Ravi; Larson, Andrew; Omary, Reed A; Salem, Riad

    2008-01-01

    Radioembolization with yttrium 90 (90Y) microspheres represents an emerging transarterial therapy for the treatment of liver malignancies that continues to generate interest in the medical community. The classic indication of treatment response is a reduction in tumor size; however, parenchymal changes (eg, necrosis, lack of enhancement, specific findings at positron emission tomography and functional magnetic resonance imaging) and other benign findings (pleural effusions, perivascular edema, contralateral hypertrophy, ring enhancement, perihepatic fluid, fibrosis) may occur following treatment, requiring proper image interpretation. With classic imaging findings and surrogates (time to progression, duration of response, disease-free interval), response rates range from 20% to 80% in patients treated for hepatocellular carcinoma or metastatic disease to the liver. Complications of 90Y radioembolization include cholecystitis, abscess, and bilomas and should be recognized early in the imaging follow-up of these patients. Radiologists who are involved in the posttreatment assessment of patients undergoing 90Y radioembolization should be familiar with the imaging findings and potential imaging pitfalls associated with this therapy. PMID:18203932

  11. Bremsstrahlung in {alpha} Decay Reexamined

    SciTech Connect

    Boie, H.; Scheit, H.; Jentschura, U. D.; Koeck, F.; Lauer, M.; Schwalm, D.; Milstein, A. I.; Terekhov, I. S.

    2007-07-13

    A high-statistics measurement of bremsstrahlung emitted in the {alpha} decay of {sup 210}Po has been performed, which allows us to follow the photon spectra up to energies of {approx}500 keV. The measured differential emission probability is in good agreement with our theoretical results obtained within the quasiclassical approximation as well as with the exact quantum mechanical calculation. It is shown that, due to the small effective electric dipole charge of the radiating system, a significant interference between the electric dipole and quadrupole contributions occurs, which is altering substantially the angular correlation between the {alpha} particle and the emitted photon.

  12. Reducing renal uptake of 90Y- and 177Lu-labeled alpha-melanocyte stimulating hormone peptide analogues

    SciTech Connect

    Miao, Yubin; Fisher, Darrell R.; Quinn, Thomas P.

    2006-06-15

    The purpose of this study was to improve the tumor-to-kidney uptake ratios of 90Y- and 177Lu-[1,2,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-Re-Cys,D-Phe,Arg]alpha-melanocyte stimulating hormone (DOTA-RE(Arg)CCMSH), through coupling a negatively charged glutamic acid (Glu) to the peptide sequence. A new peptide of DOTA-Re(Glu,Arg)CCMSH was designed, synthesized and labeled with 90Y and 177Lu. Pharmacokinetics of 90Y- and 177Lu-DOTA-RE(Glu,Arg)CCNSH were determined in B16/F1 murine melanoma-bearing C57 mice. Both exhibited significantly less renal uptake than 90Y- and 177Lu-DOTA-Re(Arg)CCMSH at 30 min and at 2, 3, and 24 h after dose administration. The renal uptake values of 90Y- and 177Lu-DOTA-Re(Glu,Arg)CCMSH were 28.16% and 28.81% of those of 90Y- and 177Lu-DOTA-RE(Arg)CCMSH, respectively, at 4 hr post-injection. We also showed higher tumor-to-kidney uptake ratios 2.28 and 1.69 times that of 90Y- and 177Lu-DOTA-Re(Arg)CCMSH, respectively, at 4 h post-injection. The90Y- and 177Lu-DOTA-Re(Glu,Arg)CCMSH activity accumulation was low in normal organs except for kidneys. Coupling a negatively charged amino acid (Glu) to the CCMSH peptide sequence dramatically reduced the renal uptake values and increased the tumor-to-kidney uptake ratios of 90Y- and 177Lu-DOTA-Re(Glu,Arg)CCMSH, facilitating their potential applications as radiopharmaceuticals for targeted radionuclide therapy of melanoma.

  13. Treatment of Advanced Pancreatic Carcinoma with 90Y-Clivatuzumab Tetraxetan: A Phase I Single-Dose Escalation Trial

    PubMed Central

    Gulec, Seza A.; Cohen, Steven J.; Pennington, Kenneth L.; Zuckier, Lionel S.; Hauke, Ralph J.; Horne, Heather; Wegener, William A.; Teoh, Nick; Gold, David V.; Sharkey, Robert M.; Goldenberg, David M.

    2014-01-01

    Purpose Humanized antibody hPAM4 specifically binds a mucin glycoprotein expressed in pancreatic adenocarcinomas. This phase I study evaluated a single dose of 90Y-clivatuzumab tetraxetan (90Y-labeled hPAM4) in patients with advanced pancreatic cancer. Experimental Design Twenty-one patients (4 stage III; 17 stage IV) received 111In-hPAM4 for imaging and serum sampling before 90Y-hPAM4. Study procedures evaluated adverse events, safety laboratories, computed tomography (CT) scans, biomarkers, pharmacokinetics, radiation dosimetry, and immunogenicity (HAHA). Results 111In-hPAM4 showed normal biodistribution with radiation dose estimates to red marrow and solid organs acceptable for radioimmunotherapy and with tumor targeting in 12 patients. One patient withdrew before 90Y-hPAM4; otherwise, 20 patients received 90Y doses of 15 (n = 7), 20 (n = 9), and 25 mCi/m2 (n = 4). Treatment was well tolerated; the only significant drug-related toxicities were (NCI CTC v.3) grade 3 to 4 neutropenia and thrombocytopenia increasing with 90Y dose. There were no bleeding events or serious infections, and most cytopenias recovered to grade 1 within 12 weeks. Three patients at 25 mCi/m2 encountered dose-limiting toxicity with grade 4 cytopenias more than 7 days, establishing 20 mCi/m2 as the maximal tolerated 90Y dose. Two patients developed HAHA of uncertain clinical significance. Most patients progressed rapidly and with CA19-9 levels increasing within 1 month of therapy, but 7 remained progression-free by CT for 1.5 to 5.6 months, including 3 achieving transient partial responses (32%–52% tumor diameter shrinkage). Conclusion 90Y-Clivatuzumab tetraxetan was well tolerated with manageable hematologic toxicity at the maximal tolerated 90Y dose, and is a potential new therapeutic for advanced pancreatic cancer. PMID:21527562

  14. A Sr-90/Y-90 field calibrator for performance testing of beta-gamma survey instruments

    SciTech Connect

    Olsher, R.H.; Haynie, J.S.

    1988-01-01

    ANSI and regulatory agency guidelines prescribe periodic performance tests for radiation protection instrumentation. Reference readings should be obtained for one point on each scale or decade normally used. A small and lightweight calibrator has been developed that facilitates field testing of beta-gamma survey instruments. The calibrator uses a 45 microcurie Sr-90/Y-90 beta source with a filter wheel to generate variable dose rates in the range from 4 to 400 mrad/hr. Thus, several ranges may be checked by dialing in appropriate filters. The design, use, and typical applications of the calibrator are described.

  15. Treatment of cystic craniopharyngioma with 90Y-Colloid. Four clinical cases.

    PubMed

    Sabaté-Llobera, A; Rojas-Camacho, J G; Mora Salvadó, J; Acebes Martín, J J; Rodríguez-Gasén, A; Ramal Leiva, D; Martín-Comín, J

    2013-01-01

    Craniopharyngioma is a histologically benign and frequently cystic intracranial tumor. It may present aggressive behavior due to compression from nearby structures. Its therapeutic management is complicated because although surgery is the usual treatment of choice, it is not exempt of high morbidity and mortality and frequent tumor recurrence. In craniopharyngiomas with a significant cystic component,internal irradiation with radioactive isotopes is a therapeutic alternative to conventional treatments. We present the cases of four patients with cystic craniopharyngiomas who were treated with intracystic administration of 90Y-colloid, and their evolution after the treatment. PMID:23291161

  16. Bremsstrahlung emission from quark stars

    SciTech Connect

    Caron, Jean-Francois; Zhitnitsky, Ariel R.

    2009-12-15

    We calculate numerically the emissivity and surface flux of electron-electron bremsstrahlung radiation from the surface of a bare quark star. The restricted electronic phase space due to the presence of an effective photon mass results in a strong suppression. The emissivity and surface flux are found to be substantially smaller than those found in previous work, to the point where electron-positron pair production would remain the dominant mechanism at all temperatures in the relativistic regime. As a consequence, e{sup +}e{sup -} pair production remains a dominant process even at low surface temperatures T{approx}10{sup 9} K as originally suggested by Usov [V. V. Usov, Phys. Rev. Lett. 80, 230 (1998).].

  17. Cerenkov luminescence imaging of αv β6 integrin expressing tumors using (90) Y-labeled peptides.

    PubMed

    Satpati, Drishty; Hausner, Sven H; Bauer, Nadine; Sutcliffe, Julie L

    2014-07-01

    Cerenkov luminescence imaging (CLI) is an emerging preclinical molecular imaging modality that tracks the radiation emitted in the visible spectrum by fast moving charged decay products of radionuclides. The aim of this study was in vitro and in vivo evaluation of the two radiotracers, (90) Y-DOTA-PEG28 -A20FMDV2 ((90) Y-1) and (90) Y-DOTA-Ahx-A20FMDV2 ((90) Y-2) (>99% radiochemical purity, 3.7 GBq/µmol specific activity) for noninvasive assessment of tumors expressing the integrin αv β6 and their future use in tumor targeted radiotherapy. Cell binding and internalization in αv β6 -positive cells was (90) Y-1: 10.1 ± 0.8%, 50.3 ± 2.1%; (90) Y-2: 22.4 ± 1.7%, 44.7 ± 1.5% with <5% binding to αv β6 -negative control cells. Biodistribution studies showed maximum αv β6 -positive tumor uptake of the radiotracers at 1-h post injection (p.i.) ((90) Y-1: 0.64 ± 0.15% ID/g; (90) Y-2: 0.34 ± 0.11% ID/g) with high renal uptake (>25% ID/g at 24 h). Because of the lower tumor uptake and high radioactivity accumulation in kidneys (that could not be reduced by pre-administration of either lysine or furosemide), the luminescence signal from the αv β6 -positive tumor was not clearly detectable in CLI images. The studies suggest that CLI is useful for indicating major organ uptake for both radiotracers; however, it reaches its limitation when there is low signal-to-noise ratio. PMID:25042833

  18. Production of large quantities of 90Y by ion-exchange chromatography using an organic resin and a chelating agent.

    PubMed

    Castillo, Abmel Xiques; Pérez-Malo, Marylaine; Isaac-Olivé, Keila; Mukhallalati, Heyam; González, Edgar Casanova; Berdeguez, Mirta Torres; Díaz, Néstor Cornejo

    2010-11-01

    The performance of a system composed of an organic cation exchanger (Dowex 50Wx8) and a chelating agent (EDTA) previously described for the successful production of (90)Y via a (90)Sr/(90)Y generator is assessed under dynamic conditions. In an attempt to overcome the established limitation of ion-exchange resins for the separation of subcurie quantities of activity, (90)Y is repeatedly isolated from an 11.8-GBq (320 mCi) (90)Sr cow using a three-column tandem arrangement. The high recovery and radionuclidic purity obtained for (90)Y and the parameters of the separation (time, eluant concentration, pH and flow rate range) strongly suggest that Ci quantities of (90)Y can be handled satisfactorily by the ion-exchange method. No replacement or treatment of the cow, low waste generation and (90)Sr losses less than 0.1% after each run were observed during the present study which, in combination with the low cost of this resin, may result in an attractive alternate method for the production of large quantities of (90)Y. PMID:21055624

  19. Efficacy and safety of 90Y ibritumomab tiuxetan (Zevalin) radioimmunotherapy for non-Hodgkin's lymphoma.

    PubMed

    Witzig, Thomas E

    2003-12-01

    Radioimmunotherapy, an emerging treatment option for certain patients with non-Hodgkin's lymphoma (NHL), enables the targeting of cytotoxic radiation to tumor cells with minimal irradiation of normal cells. Yttrium 90 ibritumomab tiuxetan (Zevalin; Biogen Idec Inc, Cambridge, MA) was approved in February 2002 for the treatment of patients with relapsed or refractory low-grade, follicular, or transformed B-cell NHL, including patients with rituximab-refractory NHL. Yttrium 90 ibritumomab tiuxetan is an effective treatment with a consistent overall response rate of 73% to 83%. It has a good safety profile and is generally well tolerated in the indicated population. The results of clinical trials show that (90)Y ibritumomab tiuxetan can be used effectively and safely in many patients with NHL, including those with mild thrombocytopenia and those with disease that is refractory to rituximab, without the adverse events associated with conventional chemotherapy and external beam radiation therapy. The use of (90)Y ibritumomab tiuxetan does not preclude subsequent therapy with other conventional treatment options. PMID:14710398

  20. [Determination of 90 Sr in milk by solvent extraction of 90Y (author's transl)].

    PubMed

    Mitsuhashi, T; Sakanoue, M

    1977-10-01

    In order to replace the conventional method using violent fuming nitric acid, a new method for the determination of 90 Sr in milk has been developed by using the solvent extraction with bis (2-ethylhexyl) phosphoric acid (HDEHP). The daughter nuclide 90Y in a radiochemical equilibrium with its parent 90Sr was extracted with 2:1 HDEHP-toluene from the acid solution (1M HCL) of milk ash sample prepared by dry-ashing. After stripping with 8M HCL, 90Y, together with stable yttrium added as carrier, was precipated as oxalate to prepare beta-counting source. The radiochemical purity was confirmed by decay curve. The decontamination of strontium was checked by applying non-dispersive fluorescence X-ray analysis using 133Ba as irradiating source. Bone samples of cow were also analyzed by the same method and the results were compared with those obtained by other methods. The duplicate crosschecking analyses of finely ground bone samples were carried out to examine the effectiveness of this method. This simple new method was found to be very effective for the routine analysis of 90Sr in these samples. PMID:579456

  1. Bremsstrahlung dileptons in ultrarelativistic heavy ion collisions

    SciTech Connect

    Jalilian-Marian, J.; Koch, V.

    1998-12-01

    We consider production of dilepton pairs through coherent electromagnetic radiation during nuclear collisions. We show that the number of pairs produced through bremsstrahlung is about two orders of magnitude smaller than the yield measured by the CERES Collaboration. Therefore, coherent bremsstrahlung can be ruled out as an explanation for the observed enhancement of low mass dileptons in CERES and HELIOS data. {copyright} {ital 1998} {ital The American Physical Society}

  2. Comparative efficacy of 177Lu and 90Y for Anti-CD20 Pretargeted Radioimmunotherapy in Murine Lymphoma Xenograft Models

    DOE PAGESBeta

    Frost, Sofia H. L.; Frayo, Shani L.; Miller, Brian W.; Orozco, Johnnie J.; Booth, Garrett C.; Hylarides, Mark D.; Lin, Yukang; Green, Damian J.; Gopal, Ajay K.; Pagel, John M.; et al

    2015-03-18

    Purpose Pretargeted radioimmunotherapy (PRIT) is a multi-step method of selectively delivering high doses of radiotherapy to tumor cells while minimizing exposure to surrounding tissues. Yttrium-90 (90Y) and lutetium-177 (177Lu) are two of the most promising beta-particle emitting radionuclides used for radioimmunotherapy, which despite having similar chemistries differ distinctly in terms of radiophysical features. These differences may have important consequences for the absorbed dose to tumors and normal organs. Whereas 90Y has been successfully applied in a number of preclinical and clinical radioimmunotherapy settings, there have been few published pretargeting studies with 177Lu. We therefore compared the therapeutic potential of targetingmore » either 90Y or 177Lu to human B-cell lymphoma xenografts in mice. Methods Parallel experiments evaluating the biodistribution, imaging, dosimetry, therapeutic efficacy, and toxicity were performed in female athymic nude mice bearing either Ramos (Burkitt lymphoma) or Granta (mantle cell lymphoma) xenografts, utilizing an anti-CD20 antibodystreptavidin conjugate (1F5-SA) and an 90Y- or 177Lu-labeled 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-biotin second step reagent. Results The two radionuclides displayed comparable biodistributions in tumors and normal organs; however, the absorbed radiation dose delivered to tumor was more than twice as high for 90Y (1.3 Gy/MBq) as for 177Lu (0.6 Gy/MBq). More importantly, therapy with 90Y-DOTAbiotin was dramatically more effective than with 177Lu-DOTA-biotin, with 100% of Ramos xenograft-bearing mice cured with 37 MBq 90Y, whereas 0% were cured using identical amounts of 177Lu-DOTA-biotin. Similar results were observed in mice bearing Granta xenografts, with 80% of the mice cured with 90Y-PRIT and 0% cured with 177Lu-PRIT. Toxicities were comparable with both isotopes. Conclusion 90Y was therapeutically superior to 177Lu for streptavidin-biotin PRIT

  3. External Beam Radiotherapy Followed by {sup 90}Y Ibritumomab Tiuxetan in Relapsed or Refractory Bulky Follicular Lymphoma

    SciTech Connect

    Burdick, Michael J.; Neumann, Donald; Pohlman, Brad; Reddy, Chandana A.; Tendulkar, Rahul D.; Macklis, Roger

    2011-03-15

    Purpose: We combined external beam radiotherapy (EBRT) with yttrium-90 ibritumomab tiuxetan ({sup 90}Y-IT) in an attempt to improve therapeutic response in patients with relapsed or refractory bulky follicular lymphoma (RRBFL). Methods and Materials: Between February 2006 and September 2007, 11 patients with RRBFL were treated with EBRT followed by {sup 90}Y-IT. Bulky disease (BD) was defined as >5 cm. EBRT was delivered to BD as 2,400 cGy in eight fractions using computed tomography (CT)-based planning. BD was contoured as the gross tumor volume. A planning margin of 1 to 2 cm was added depending on anatomical location. After recovery of complete blood counts (CBC), {sup 90}Y-IT was administered at a dose of 0.3 or 0.4 mCi/kg depending on platelet counts. Hematologic toxicity was monitored through weekly CBC. Response was measured by positron emission tomography/CT or CT 3-4 months after {sup 90}Y-IT. Results: Only 2 patients required prolonged breaks between EBRT and {sup 90}Y-IT. The median time after {sup 90}Y-IT for platelets to recover to >100,000/ml was 55 days (range, 41-128 days). Platelet counts for 1 patient, who had received 4 previous chemotherapy regimens, never reached 100,000/ml. The complete and overall responses to combined therapy as measured 3-4 months after {sup 90}Y-IT were 64%. No patients relapsed within the EBRT field. With a median follow-up of 36.1 months, 6 patients have relapsed, 2 of whom have died. Median progression-free survival was 17.5 months. Conclusions: In contrast to prior failure analysis data for RRBFL patients treated with {sup 90}Y-IT alone, a brief course of EBRT prevented relapse in sites of BD. EBRT used to pretreat bulky sites may improve clinical outcomes and potentially extend survival when combined with {sup 90}Y-IT.

  4. Comparative Efficacy of 177Lu and 90Y for Anti-CD20 Pretargeted Radioimmunotherapy in Murine Lymphoma Xenograft Models

    PubMed Central

    Frost, Sofia H. L.; Frayo, Shani L.; Miller, Brian W.; Orozco, Johnnie J.; Booth, Garrett C.; Hylarides, Mark D.; Lin, Yukang; Green, Damian J.; Gopal, Ajay K.; Pagel, John M.; Bäck, Tom A.; Fisher, Darrell R.; Press, Oliver W.

    2015-01-01

    Purpose Pretargeted radioimmunotherapy (PRIT) is a multi-step method of selectively delivering high doses of radiotherapy to tumor cells while minimizing exposure to surrounding tissues. Yttrium-90 (90Y) and lutetium-177 (177Lu) are two of the most promising beta-particle emitting radionuclides used for radioimmunotherapy, which despite having similar chemistries differ distinctly in terms of radiophysical features. These differences may have important consequences for the absorbed dose to tumors and normal organs. Whereas 90Y has been successfully applied in a number of preclinical and clinical radioimmunotherapy settings, there have been few published pretargeting studies with 177Lu. We therefore compared the therapeutic potential of targeting either 90Y or 177Lu to human B-cell lymphoma xenografts in mice. Methods Parallel experiments evaluating the biodistribution, imaging, dosimetry, therapeutic efficacy, and toxicity were performed in female athymic nude mice bearing either Ramos (Burkitt lymphoma) or Granta (mantle cell lymphoma) xenografts, utilizing an anti-CD20 antibody-streptavidin conjugate (1F5-SA) and an 90Y- or 177Lu-labeled 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-biotin second step reagent. Results The two radionuclides displayed comparable biodistributions in tumors and normal organs; however, the absorbed radiation dose delivered to tumor was more than twice as high for 90Y (1.3 Gy/MBq) as for 177Lu (0.6 Gy/MBq). More importantly, therapy with 90Y-DOTA-biotin was dramatically more effective than with 177Lu-DOTA-biotin, with 100% of Ramos xenograft-bearing mice cured with 37 MBq 90Y, whereas 0% were cured using identical amounts of 177Lu-DOTA-biotin. Similar results were observed in mice bearing Granta xenografts, with 80% of the mice cured with 90Y-PRIT and 0% cured with 177Lu-PRIT. Toxicities were comparable with both isotopes. Conclusion 90Y was therapeutically superior to 177Lu for streptavidin-biotin PRIT approaches in

  5. Comparative Efficacy of 177Lu and 90Y for Anti-CD20 Pretargeted Radioimmunotherapy in Murine Lymphoma Xenograft Models

    SciTech Connect

    Frost, Sophia; Frayo, Shani; Miller, Brian W.; Orozco, Johnnie J.; Booth, Garrett C.; Hylarides, Mark; Lin, Yukang; Green, Damian J.; Gopal, Ajay K.; Pagel, John M.; Back, Tom; Fisher, Darrell R.; Press, Oliver W.

    2015-03-01

    Pretargeted radioimmunotherapy (PRIT) is a multi-step method of selectively delivering high doses of radiotherapy to tumor cells while minimizing exposure to surrounding tissues. Yttrium-90 (90Y) and lutetium-177 (177Lu) are two of the most promising beta-particle emitting radionuclides used for radioimmunotherapy, which despite having similar chemistries differ distinctly in terms of radiophysical features. These differences may have important consequences for the absorbed dose to tumors and normal organs. Whereas 90Y has been successfully applied in a number of preclinical and clinical radioimmunotherapy settings, there have been few published pretargeting studies with 177Lu. We therefore compared the therapeutic potential of targeting either 90Y or 177Lu to human B-cell lymphoma xenografts in mice.

  6. Recent advances in SPECT

    SciTech Connect

    Tsui, Benjamin M. W.

    1998-08-28

    Single photon emission computed tomography (SPECT) is a medical imaging modality that combines conventional nuclear medicine imaging technique and methods of computed tomography (CT). From images that represent the biodistribution of the injected radiopharmaceutical in the patient, SPECT provides functional information that is unique. The first SPECT system was developed in the sixties. However, early progress of SPECT was hampered by the lack of adequate image reconstruction methods. The development of x-ray CT and image reconstruction methods in the seventies spurred a renewed interest in SPECT. In 1981, the first commercial SPECT system based on a single rotating camera was available for clinical use. Today, most modern SPECT systems consist of multiple cameras that rotate around the patients. They have better spatial resolution and higher detection efficiency as compared to the earlier single camera systems. Recently, a new generation of dual camera systems allowing for coincidence imaging of positron emitting radiopharmaceuticals has emerged in the commercial market. Additionally, new quantitative image reconstruction methods are under development. They compensate for image degrading factors including attenuation, collimator-detector blurring and scatter. Also, they result in SPECT images with improved image quality and more accurately represent the three-dimensional radioactivity distribution in the patient. Such advances in radiopharmaceuticals, instrumentation, image reconstruction, compensation methods, and clinical applications have fueled a steady growth of SPECT as an important diagnostic tool in patient management.

  7. Anomalous fluorescence line intensity in megavoltage bremsstrahlung

    NASA Astrophysics Data System (ADS)

    Pereira, Nino; Litz, Marc; Merkel, George; Schumer, Joseph; Seely, John; Carroll, Jeff

    2009-11-01

    A Cauchois transmission crystal spectrometer intended for laser plasma diagnostics has measured an anomalous ratio between the fluorescence lines in megavoltage bremsstrahlung. When observed in reflection, Kα1 fluorescence is twice as strong as the Kβ line, as is usual. However, in forward-directed bremsstrahlung from a 2 MV end point linear accelerator with a tungsten converter, the Kα1 and Kβ fluorescence are approximately equal. The anomalous fluorescence line ratio, unity, reflects the large amount of fluorescence generated on the side of the converter where the electrons enter, and the differential attenuation of the fluorescence photons as they pass through the converter to opposite side. Understanding of fluorescence in megavoltage bremsstrahlung is relevant to the explanation of anomalous line ratios in spectra produced by high-energy electrons generated by intense femtosecond laser irradiation.

  8. Bremsstrahlung from relativistic heavy ions in matter

    SciTech Connect

    Soerensen, Allan H.

    2010-02-15

    The emission of electromagnetic radiation by relativistic bare heavy ions penetrating ordinary matter is investigated. Our main aim is to determine the bremsstrahlung which we define as the radiation emitted when the projectile does not break up. It pertains to collisions without nuclear contact ('ultraperipheral collisions'). Requirement of coherent action of the nucleons in order to keep the penetrating projectile intact limits bremsstrahlung to relatively soft photons. The spectrum shows a resonance structure with peak position near 2{gamma} times the position of the giant dipole resonance, that is, near 25{gamma} MeV for a lead ion ({gamma}{identical_to}E/Mc{sup 2} is the Lorentz factor of the projectile of energy E and mass M). The maximum exceeds the bremsstrahlung from a hypothetical structureless, pointlike particle of the same charge and mass as the incoming nucleus, but rapid depletion follows on the high-energy side of the peak. As a result of its relative softness, bremsstrahlung never dominates the energy-loss process for heavy ions. As to the emission of electromagnetic radiation in collisions with nuclear break-up, it appears modest when pertaining to incoherent action of the projectile nucleons in noncontact collisions. In collisions with nuclear contact, though, substantial radiation is emitted. It overshoots the bremsstrahlung. However, despite the violence of contact events, the associated photon emission only exceeds the radiation from a hypothetical structureless pointlike nucleus [emitted energy per unit photon-energy interval essentially constant up to ({gamma}-1)Mc{sup 2}] at relatively low photon energies (for lead roughly below 0.2{gamma} GeV, a limit which is about an order of magnitude above the position of the bremsstrahlung peak). Results are presented for bare lead ions penetrating a solid lead target at energies of 158 GeV/n ({gamma}=170) and beyond.

  9. Post-mortem considerations of Yttrium-90 90Y microsphere therapy procedures.

    PubMed

    Nelson, Kevin; Vause, Paul E; Koropova, Polina

    2008-11-01

    Yttrium-90 (Y) microspheres, either in the form of resin beads or glass, are currently used to treat unresectable hepatocellular cancer. It has been discovered that long-lived contaminants, principally Eu and Eu, can be found in the waste generated by this procedure. Recently, at our medical facility, an elevated count rate was discovered on a deceased patient scheduled to have an autopsy and who had undergone Y microsphere therapy nearly 5 months previously. Regulatory issues arose when the family of the patient requested that the body of the deceased be cremated. In this particular instance the exposure rate from the body was below regulatory concern; however, the potential contamination and exposure from these long-lived contaminants cannot be ignored for individuals working in the autopsy room, funeral home embalming area, and crematorium. Information provided to potential patients in pamphlet form from the manufacturer failed to identify the existence of long-lived contaminants and possible difficulties associated with cremation. To ensure potential Y microsphere patients and family members are aware of the possible existence of long-lived contaminants, a patient consent and notification form has been developed. The proper disposal of residual material associated with these procedures, i.e., long-lived radioactive contaminants in explanted organs, pose additional difficulties. Further education of medical staff and funeral home directors with crematoriums is necessary. Close cooperation with the regulatory authority was instrumental in resolving this situation. PMID:18849708

  10. (90)Y microspheres prepared by sol-gel method, promising medical material for radioembolization of liver malignancies.

    PubMed

    Łada, Wiesława; Iller, Edward; Wawszczak, Danuta; Konior, Marcin; Dziel, Tomasz

    2016-10-01

    A new technology for the production of radiopharmaceutical (90)Y microspheres in the form of spherical yttrium oxide grains obtained by sol-gel method has been described. The authors present and discuss the results of investigations performed in the development of new production technology of yttrium microspheres and determination of their physic-chemical properties. The final product has the structure of spherical yttrium oxide grains with a diameter 25-100μm, is stable and free from contaminants. Irradiation of 20mg samples of grains with diameter of 20-50μm in the thermal neutron flux of 1.7×10(14)cm(-2)s(-1) at the core of MARIA research nuclear reactor allowed to obtain microspheres labelled with the (90)Y isotope on the way of the nuclear reaction (89)Y(n, ɤ)(90)Y. Specific activity of irradiated microspheres has been determined by application of absolute triple to double coincidence ratio method (TDCR) and has been evaluated at 190MBq/mg Y. (90)Y microspheres prepared by the proposed technique can be regarded as a promising medical material for radioembolization of liver malignancies. PMID:27287162

  11. Dosimetric comparison of {sup 90}Y, {sup 32}P, and {sup 186}Re radiocolloids in craniopharyngioma treatments

    SciTech Connect

    Sadeghi, Mahdi; Karimi, Elham; Hosseini, S. Hamed

    2009-11-15

    Purpose: In the radionuclide treatment of some forms of brain tumors such as craniopharyngiomas, the selection of the appropriate radionuclide for therapy is a key element in treatment planning. The aim was to study the influence by considering the beta-emitter radionuclide dose rate in an intracranial cyst. Methods: Dosimetry was performed using the MCNP4C radiation transport code. Analytical dosimetry was additionally performed using the Loevinger and the Berger formulas in the MATLAB software. Each result was compared under identical conditions. The advantages and disadvantages of using {sup 90}Y versus {sup 32}P and {sup 186}Re were investigated. Results: The dose rate at the inner surface of the cyst wall was estimated to be 400 mGy/h for a 1 MBq/ml concentration of {sup 90}Y. Under identical conditions of treatment, the corresponding dose rates were 300 mGy/h for {sup 32}P and 160 mGy/h for {sup 186}Re. For a well-defined cyst radius and identical wall thickness, higher dose rates resulted for {sup 90}Y. Conclusions: To achieve the same radiological burden, the required amount of physical activity of injectable solution is lower for {sup 32}P. This is found to be a consequence of both the radionuclide physical half-life and the pattern of energy deposition from the emitted radiation. According to the half-life and dose-rate results, {sup 90}Y would be a good substitute for {sup 32}P.

  12. 90Y-Labeled Anti-ROBO1 Monoclonal Antibody Exhibits Antitumor Activity against Small Cell Lung Cancer Xenografts

    PubMed Central

    Fujiwara, Kentaro; Koyama, Keitaro; Suga, Kosuke; Ikemura, Masako; Saito, Yasutaka; Hino, Akihiro; Iwanari, Hiroko; Kusano-Arai, Osamu; Mitsui, Kenichi; Kasahara, Hiroyuki; Fukayama, Masashi; Kodama, Tatsuhiko; Hamakubo, Takao; Momose, Toshimitsu

    2015-01-01

    Introduction ROBO1 is a membrane protein that contributes to tumor metastasis and angiogenesis. We previously reported that 90Y-labeled anti-ROBO1 monoclonal antibody (90Y-anti-ROBO1 IgG) showed an antitumor effect against ROBO1-positive tumors. In this study, we performed a biodistribution study and radioimmunotherapy (RIT) against ROBO1-positive small cell lung cancer (SCLC) models. Methods For the biodistribution study, 111In-labeled anti-ROBO1 monoclonal antibody (111In-anti-ROBO1 IgG) was injected into ROBO1-positive SCLC xenograft mice via the tail vein. To evaluate antitumor effects, an RIT study was performed, and SCLC xenograft mice were treated with 90Y-anti-ROBO1 IgG. Tumor volume and body weight were periodically measured throughout the experiments. The tumors and organs of mice were then collected, and a pathological analysis was carried out. Results As a result of the biodistribution study, we observed tumor uptake of 111In-anti-ROBO1 IgG. The liver, kidney, spleen, and lung showed comparably high accumulation of 111In-labeled anti-ROBO1. In the RIT study, 90Y-anti-ROBO1 IgG significantly reduced tumor volume compared with baseline. Pathological analyses of tumors revealed coagulation necrosis and fatal degeneration of tumor cells, significant reduction in the number of Ki-67-positive cells, and an increase in the number of apoptotic cells. A transient reduction of hematopoietic cells was observed in the spleen, sternum, and femur. Conclusions These results suggest that RIT with 90Y-anti-ROBO1 IgG is a promising treatment for ROBO1-positive SCLC. PMID:26017283

  13. Radiative corrections to high energy lepton bremsstrahlung on heavy nuclei

    NASA Astrophysics Data System (ADS)

    Arbuzov, Andrej B.

    2008-01-01

    One-loop radiative corrections to the leptonic tensor in high energy bremsstrahlung on heavy nuclei are calculated. Virtual and real photon radiation is taken into account. Double bremsstrahlung is simulated by means of Monte Carlo. Numerical results are presented for the case of muon bremsstrahlung in conditions of the COMPASS experiment at CERN.

  14. Goniometer Control System for Coherent Bremsstrahlung Production

    SciTech Connect

    Acosta, Victor M

    2002-08-15

    A system for the generation of a high-intensity, quasi-monochromatic photon beam is discussed. The theory behind coherent bremsstrahlung photon beam production is analyzed and developed. The mechanics of a goniometer control system are presented. The software developed for remote control of the goniometer is also discussed. Finally, the results from various performance measurements are included.

  15. Bremsstrahlung gamma rays from light dark matter

    SciTech Connect

    Cirelli, Marco; Zaharijas, Gabrijela E-mail: serpico@lapth.cnrs.fr

    2013-11-01

    We discuss the often-neglected role of bremsstrahlung processes on the interstellar gas in computing indirect signatures of Dark Matter (DM) annihilation in the Galaxy, particularly for light DM candidates in the phenomenologically interesting O(10) GeV mass range. Especially from directions close to the Galactic Plane, the γ-ray spectrum is altered via two effects: directly, by the photons emitted in the bremsstrahlung process by energetic electrons which are among the DM annihilation byproducts; indirectly, by the modification of the same electron spectrum, due to the additional energy loss process in the diffusion-loss equation (e.g. the resulting inverse Compton emission is altered). We quantify the importance of the bremsstrahlung emission in the GeV energy range, showing that it is sometimes the dominant component of the γ-ray spectrum. We also find that, in regions in which bremsstrahlung dominates energy losses, the related γ-ray emission is only moderately sensitive to possible large variations in the gas density. Still, we stress that, for computing precise spectra in the (sub-)GeV range, it is important to obtain a reliable description of the Galaxy gas distribution as well as to compute self-consistently the γ-ray emission and the solution to the diffusion-loss equation. For example, these are crucial issues to quantify and interpret meaningfully γ-ray map 'residuals' in the inner Galaxy.

  16. Post-radioembolization yttrium-90 PET/CT - part 1: diagnostic reporting

    PubMed Central

    2013-01-01

    Background Yttrium-90 (90Y) positron emission tomography with integrated computed tomography (PET/CT) represents a technological leap from 90Y bremsstrahlung single-photon emission computed tomography with integrated computed tomography (SPECT/CT) by coincidence imaging of low abundance internal pair production. Encouraged by favorable early experiences, we implemented post-radioembolization 90Y PET/CT as an adjunct to 90Y bremsstrahlung SPECT/CT in diagnostic reporting. Methods This is a retrospective review of all paired 90Y PET/CT and 90Y bremsstrahlung SPECT/CT scans over a 1-year period. We compared image resolution, ability to confirm technical success, detection of non-target activity, and providing conclusive information about 90Y activity within targeted tumor vascular thrombosis. 90Y resin microspheres were used. 90Y PET/CT was performed on a conventional time-of-flight lutetium-yttrium-oxyorthosilicate scanner with minor modifications to acquisition and reconstruction parameters. Specific findings on 90Y PET/CT were corroborated by 90Y bremsstrahlung SPECT/CT, 99mTc macroaggregated albumin SPECT/CT, follow-up diagnostic imaging or review of clinical records. Results Diagnostic reporting recommendations were developed from our collective experience across 44 paired scans. Emphasis on the continuity of care improved overall diagnostic accuracy and reporting confidence of the operator. With proper technique, the presence of background noise did not pose a problem for diagnostic reporting. A counter-intuitive but effective technique of detecting non-target activity is proposed, based on the pattern of activity and its relation to underlying anatomy, instead of its visual intensity. In a sub-analysis of 23 patients with a median follow-up of 5.4 months, 90Y PET/CT consistently outperformed 90Y bremsstrahlung SPECT/CT in all aspects of qualitative analysis, including assessment for non-target activity and tumor vascular thrombosis. Parts of viscera closely

  17. Personalized predictive lung dosimetry by technetium-99m macroaggregated albumin SPECT/CT for yttrium-90 radioembolization

    PubMed Central

    2014-01-01

    Background For yttrium-90 (90Y) radioembolization, the common practice of assuming a standard 1,000-g lung mass for predictive dosimetry is fundamentally incongruent with the modern philosophy of personalized medicine. We recently developed a technique of personalized predictive lung dosimetry using technetium-99m (99mTc) macroaggregated albumin (MAA) single photon emission computed tomography with integrated CT (SPECT/CT) of the lung as part of our routine dosimetric protocol for 90Y radioembolization. Its rationales are the technical superiority of SPECT/CT over planar scintigraphy, ease and convenience of lung auto-segmentation CT densitovolumetry, and dosimetric advantage of patient-specific lung parenchyma masses. Methods This is a retrospective study of our pulmonary clinical outcomes and comparison of lung dosimetric accuracy and precision by 99mTc MAA SPECT/CT versus conventional planar methodology. 90Y resin microspheres (SIR-Spheres) were used for radioembolization. Diagnostic CT densitovolumetry was used as a reference for lung parenchyma mass. Pulmonary outcomes were based on follow-up diagnostic CT chest or X-ray. Results Thirty patients were analyzed. The mean lung parenchyma mass of our Southeast Asian cohort was 822 ± 103 g standard deviation (95% confidence interval 785 to 859 g). Patient-specific lung parenchyma mass estimation by CT densitovolumetry on 99mTc MAA SPECT/CT is accurate (bias −21.7 g) and moderately precise (95% limits of agreement −194.6 to +151.2 g). Lung mean radiation absorbed doses calculated by 99mTc MAA SPECT/CT and planar methodology are both accurate (bias <0.5 Gy), but 99mTc MAA SPECT/CT offers better precision over planar methodology (95% limits of agreement −1.76 to +2.40 Gy versus −3.48 to +3.31 Gy, respectively). None developed radiomicrosphere pneumonitis when treated up to a lung mean radiation absorbed dose of 18 Gy at a median follow-up of 4.4 months. Conclusions Personalized predictive lung

  18. A review of 3D image-based dosimetry, technical considerations and emerging perspectives in 90Y microsphere therapy

    PubMed Central

    O’ Doherty, Jim

    2016-01-01

    Yttrium-90 radioembolization (90Y-RE) is a well-established therapy for the treatment of hepatocellular carcinoma (HCC) and also of metastatic liver deposits from other malignancies. Nuclear Medicine and Cath Lab diagnostic imaging takes a pivotal role in the success of the treatment, and in order to fully exploit the efficacy of the technique and provide reliable quantitative dosimetry that are related to clinical endpoints in the era of personalized medicine, technical challenges in imaging need to be overcome. In this paper, the extensive literature of current 90Y-RE techniques and challenges facing it in terms of quantification and dosimetry are reviewed, with a focus on the current generation of 3D dosimetry techniques. Finally, new emerging techniques are reviewed which seek to overcome these challenges, such as high-resolution imaging, novel surgical procedures and the use of other radiopharmaceuticals for therapy and pre-therapeutic planning. PMID:27182449

  19. Hepatectomy After Yttrium-90 (Y90) Radioembolization-Induced Liver Fibrosis.

    PubMed

    Maker, Ajay V; August, Carey; Maker, Vijay K; Weisenberg, Elliot

    2016-04-01

    An obese 55-year-old woman with nonalcoholic fatty liver disease presented 7 years after resection of a T3N1 ileal carcinoid tumor with an elevated chromogranin A, multifocal metastatic disease to the liver, and carcinoid syndrome. She underwent right hepatic artery yttrium-90 (Y90) radioembolization, followed a month later by selective Y90 treatment to segment IV. She then presented to our clinic 10 months later, remaining symptomatic with flushing, diarrhea, anxiety, myalgia, pain, and persistent night sweats despite Sandostatin administration. At least 11 tumors were identified in the right lobe of the liver and three in segment IV on liver-specific imaging. These lesions were stable over a year with no new lesions. At exploration, there was marked hypertrophy of the left lateral segment due to the yttrium-90 treatment of segments IV-VIII, corresponding with preoperative volumetrics predicting a functional liver remnant (FLR) of 40% after extended right hepatectomy. The right lobe and segment IV were fibrotic, hard, and visibly damaged. The gland had a thick, fibrotic capsule, and the parenchyma was dense, inflexible, and difficult to dissect, consistent with the previously reported morbidity of these operations. Extended right hepatectomy was performed. Final pathology demonstrated 15 foci of metastatic well-differentiated neuroendocrine carcinoma that were negative for necrosis, as was expected given her continued symptoms despite radioembolization. Numerous amorphous spheres, frequently in clusters, were present in segments IV-VIII in vessels and approximating tumors consistent with prior Y90 radioembolization. The patient had an uneventful post-operative recovery and remains symptom free on follow-up. Treatment options for metastatic tumors to the liver have increased in recent years and currently include radioembolization in selected patients. Surgical cytoreduction and complete metastasectomy continue to offer improvement in symptoms, quality of life, and

  20. Safety of {sup 90}Y Radioembolization in Patients Who Have Undergone Previous External Beam Radiation Therapy

    SciTech Connect

    Lam, Marnix G.E.H.; Abdelmaksoud, Mohamed H.K.; Chang, Daniel T.; Eclov, Neville C.; Chung, Melody P.; Koong, Albert C.; Louie, John D.; Sze, Daniel Y.

    2013-10-01

    Purpose: Previous external beam radiation therapy (EBRT) is theoretically contraindicated for yttrium-90 ({sup 90}Y) radioembolization (RE) because the liver has a lifetime tolerance to radiation before becoming vulnerable to radiation-induced liver disease. We analyzed the safety of RE as salvage treatment in patients who had previously undergone EBRT. Methods and Materials: Between June 2004 and December 2010, a total of 31 patients who had previously undergone EBRT were treated with RE. Three-dimensional treatment planning with dose–volume histogram (DVH) analysis of the liver was used to calculate the EBRT liver dose. Liver-related toxicities including RE-induced liver disease (REILD) were reviewed and classified according to Common Terminology Criteria for Adverse Events version 4.02. Results: The mean EBRT and RE liver doses were 4.40 Gy (range, 0-23.13 Gy) and 57.9 Gy (range, 27.0-125.9 Gy), respectively. Patients who experienced hepatotoxicity (≥grade2; n=12) had higher EBRT mean liver doses (7.96 ± 8.55 Gy vs 1.62 ± 3.39 Gy; P=.037), the only independent predictor in multivariate analysis. DVH analysis showed that the fraction of liver exposed to ≥30 Gy (V30) was the strongest predictor of hepatotoxicity (10.14% ± 12.75% vs 0.84% ± 3.24%; P=.006). All patients with V30 >13% experienced hepatotoxicity. Fatal REILD (n=2) occurred at the 2 highest EBRT mean liver doses (20.9 Gy and 23.1 Gy) but also at the highest cumulative liver doses (91.8 Gy and 149 Gy). Conclusions: Prior exposure of the liver to EBRT may lead to increased liver toxicity after RE treatment, depending on fractional liver exposure and dose level. The V30 was the strongest predictor of toxicity. RE appears to be safe for the treatment of hepatic malignancies only in patients who have had limited hepatic exposure to prior EBRT.

  1. Development of anthropomorphic hand phantoms for personal dosimetry in 90Y-Zevalin preparation and patient delivering.

    PubMed

    Ciolini, R; d'Errico, F; Traino, A C; Paternostro, E; Laganà, A; Romei, C; Pazzagli, F; Del Gratta, A

    2014-01-01

    Anthropomorphic tissue-equivalent hand phantoms were achieved to measure the extremity dose involved in Zevalin (90)Y-labelling and patient delivering procedure for radioimmunotherapy treatment of non-Hodgkin lymphoma. The extremity doses to hands and wrists of operators were measured by using thermoluminescent detectors mounted on the developed phantoms. Measurements of chest- and lens-equivalent doses performed on a Rando phantom are also reported. PMID:23960242

  2. Inhibitory effects of 90Sr/90Y β-irradiation on alkali burn-induced corneal neovascularization in rats

    PubMed Central

    LIN, YUANQIANG; MA, QINGJIE; LIN, SHAN; ZHOU, HONGYAN; WEN, QIANG; GAO, SHI; CHENG, GUANGHUI

    2016-01-01

    The aim of the present study was to investigate the inhibitory effects of 90Sr-90Y β-irradiation in a rat model of alkali burn-induced corneal neovascularization (CNV). Alkali burn-induced CNV was induced in the right eyes of 30 female Wistar rats, which were randomly divided into the following three groups (n=10/group): i) The alkali burn control group, which received a balanced salt solution treatment; ii) group 1, which received treatment with angiogenesis inhibitors; and iii) group 2, which received 90Sr-90Y β-irradiation treatment. A further 10 female Wistar rats comprised a blank control group and received only balanced salt solution. Digital photographs of the corneas were acquired and the area of NV was calculated. In addition, the expression levels of matrix metalloproteinase (MMP)-9, vascular endothelial growth factor (VEGF), VEGF receptor (VEGFR)-1 and VEGFR-2 in alkali-burned rat corneas were determined using western blot analysis. The results suggested that the number of new vessels and the area of CNV were significantly decreased in groups 1 and 2, as compared with the alkali burn group at each time point (P<0.05). In addition, the number of inflammatory cells and the degree of edema were decreased in groups 1 and 2, as compared with the alkali burn group, with group 2 exhibiting the most marked reduction. Western blot analysis demonstrated that the expression levels of MMP-9, VEGF, VEGFR-1 and VEGFR-2 were significantly decreased in groups 1 and 2, as compared with the alkali burn control group, with group 2 exhibiting the most significant reduction (P<0.05). The results of the present study suggested that 90Sr-90Y β-irradiation and angiogenesis inhibitor treatments were able to inhibit alkali burn-induced CNV, although 90Sr-90Y β-irradiation may be more effective. PMID:26893623

  3. Pathologic response and microdosimetry of {sup 90}Y microspheres in man: Review of four explanted whole livers

    SciTech Connect

    Kennedy, Andrew S. . E-mail: akennedy@wakerad.com; Nutting, Charles; Coldwell, Douglas; Gaiser, James; Drachenberg, Cinthia

    2004-12-01

    Introduction: Radioactive microsphere {sup 90}Y therapy is increasingly used for primary and metastatic solid tumors in the liver. We present an analysis of 4 explanted livers previously treated with {sup 90}Y microsphere agents (glass or resin). One tumor nodule was analyzed with submillimeter three-dimensional microdosimetry. Methods and materials: Four patients received hepatic artery delivery of {sup 90}Y microspheres for unresectable hepatocellular and colon cancers. Whole livers were explanted as part of lifesaving cadaveric transplant in 2 patients with hepatoma. These patients had received glass microspheres as a procedural bridge to transplant. Autopsy was performed on 2 patients with colon cancer who died of progressive metastatic disease and who had been treated with resin microspheres. Complete pathologic review was performed on each whole liver, including estimation of the response of the tumor to therapy, distribution of microspheres in the tumor and normal liver tissues, and normal-tissue radiation response. A biopsy taken from the edge of a tumor nodule was sectioned serially for three-dimensional radiation dosimetry analyses. Three-dimensional microsphere coordinates within the biopsy specimen were used to calculate dosage using a three-dimensional dose kernel. Isodose coverage of tumor and normal liver areas and total dose delivered were determined. Results: Preferential and heterogeneous deposition of microspheres was noted at the edge of tumor nodules compared with the center portion of the tumor or normal liver parenchyma. Both glass and resin microspheres delivered high cumulative doses to the tumor, which varied from 100 Gy to more than 3000 Gy. No veno-occlusive disease or widespread radiation hepatitis was seen. Conclusion: Microsphere ({sup 90}Y) therapy delivers high numbers of spheres with resulting high total doses of radiation, preferentially in the periphery of tumors. Normal liver parenchyma showed little radiation effect away from

  4. Magnetically directed poly(lactic acid) [sup 90]Y-microspheres: Novel agents for targeted intracavitary radiotherapy

    SciTech Connect

    Haefeli, U.O.; Sweeney, S.M.; Beresford, B.A.; Sim, E.H.; Macklis, R.M. . Joint Center for Radiation Therapy)

    1994-08-01

    High energy [beta]-emitting radioisotopes like Yttrium-90 have a radiotoxic range of about one centimeter. For cancer treatment they must be brought near the tumor cells and kept there for as long as they are radioactive. The authors developed as carriers for the ionic form of [sup 90]Y a matrix-type polymeric drug delivery system, poly(lactic acid) (PLA) microspheres. This radiopharmaceutical could be selectively delivered to the target site after incorporating 10% Fe[sub 3]O[sub 4] which made the magnetic microspheres (MMS) responsive to an external magnetic field. Furthermore, MMS are biodegradable and slowly hydrolyze into physiologic lactic acid after the radioactivity is completely decayed. Previously prepared 10--40 [mu]m MMS were radiochemically loaded to high specific activity with [sup 90]Y at a pH of 5.7. Stability studies showed that approximately 95% of added [sup 90]Y is retained within the PLA matrix after 28 days (> 10 half-lives) at 37 C in serum, and electron microscopy showed that the microspheres retained their characteristic morphologic appearance for the same time period. Cytotoxicity studies with SK-N-SH neuroblastoma cells growing in monolayer showed that the radiocytotoxicity of the microspheres could be directed magnetically to either kill or spare specific cell populations, thus making them of great interest for targeted intracavitary tumor therapy. The authors are currently optimizing this system for use in the treatment of neoplastic meningitis.

  5. Megavoltage bremsstrahlung end point voltage diagnostic.

    PubMed

    Feroli, T; Litz, M S; Merkel, G; Smith, T; Pereira, N R; Carroll, J J

    2009-03-01

    In a material, a beam of x rays is accompanied by various kinds of secondary radiation, including Compton electrons from collisions between the x rays and the material's electrons. For megavoltage bremsstrahlung in air, many of these Compton electrons are forward-directed and fast enough to be deflected outside the beam's edge by a magnetic field perpendicular to the beam. At the beam's edge, the dose from the deflected Compton electrons has a pattern that depends on the radiation's end point energy. Dose patterns measured with radiochromic film on a nominally 1 and 2 MV linear accelerator agree reasonably well with the corresponding Monte Carlo computations. With further development, the dose pattern produced outside the beam by such a sweeper magnet could become a noninvasive way to monitor megavoltage bremsstrahlung, when the end point energies are difficult to determine with other methods. PMID:19334938

  6. Megavoltage bremsstrahlung end point voltage diagnostic

    SciTech Connect

    Feroli, T.; Litz, M. S.; Merkel, G.; Smith, T.; Pereira, N. R.; Carroll, J. J.

    2009-03-15

    In a material, a beam of x rays is accompanied by various kinds of secondary radiation, including Compton electrons from collisions between the x rays and the material's electrons. For megavoltage bremsstrahlung in air, many of these Compton electrons are forward-directed and fast enough to be deflected outside the beam's edge by a magnetic field perpendicular to the beam. At the beam's edge, the dose from the deflected Compton electrons has a pattern that depends on the radiation's end point energy. Dose patterns measured with radiochromic film on a nominally 1 and 2 MV linear accelerator agree reasonably well with the corresponding Monte Carlo computations. With further development, the dose pattern produced outside the beam by such a sweeper magnet could become a noninvasive way to monitor megavoltage bremsstrahlung, when the end point energies are difficult to determine with other methods.

  7. Fractionated Radioimmunotherapy With 90Y-Clivatuzumab Tetraxetan and Low-Dose Gemcitabine Is Active in Advanced Pancreatic Cancer

    PubMed Central

    Ocean, Allyson J.; Pennington, Kenneth L.; Guarino, Michael J.; Sheikh, Arif; Bekaii-Saab, Tanios; Serafini, Aldo N.; Lee, Daniel; Sung, Max W.; Gulec, Seza A.; Goldsmith, Stanley J.; Manzone, Timothy; Holt, Michael; O’Neil, Bert H.; Hall, Nathan; Montero, Alberto J.; Kauh, John; Gold, David V.; Horne, Heather; Wegener, William A.; Goldenberg, David M.

    2014-01-01

    BACKGROUND It has been demonstrated that the humanized clivatuzumab tetraxetan (hPAM4) antibody targets pancreatic ductal carcinoma selectively. After a trial of radioimmunotherapy that determined the maximum tolerated dose of single-dose yttrium-90-labeled hPAM4 (90Y-hPAM4) and produced objective responses in patients with advanced pancreatic ductal carcinoma, the authors studied fractionated radioimmunotherapy combined with low-dose gemcitabine in this disease. METHODS Thirty-eight previously untreated patients (33 patients with stage IV disease and 5 patients with stage III disease) received gemcitabine 200 mg/m2 weekly for 4 weeks with 90Y-hPAM4 given weekly in Weeks 2, 3, and 4 (cycle 1), and the same cycle was repeated in 13 patients (cycles 2–4). In the first part of the study, 19 patients received escalating weekly 90Y doses of 6.5 mCi/m2, 9.0 mCi/m2, 12.0 mCi/m2, and 15.0 mCi/m2. In the second portion, 19 additional patients received weekly doses of 9.0 mCi/m2 or 12.0 mCi/m2. RESULTS Grade 3/4 thrombocytopenia or neutropenia (according to version 3.0 of the National Cancer Institute’s Common Terminology Criteria for Adverse Events) developed in 28 of 38 patients after cycle 1 and in all retreated patients; no grade >3 nonhematologic toxicities occurred. Fractionated dosing of cycle 1 allowed almost twice the radiation dose compared with single-dose radioimmunotherapy. The maximum tolerated dose of 90Y-hPAM4 was 12.0 mCi/m2 weekly for 3 weeks for cycle 1, with ≤9.0 mCi/m2 weekly for 3 weeks for subsequent cycles, and that dose will be used in future trials. Six patients (16%) had partial responses according to computed tomography-based Response Evaluation Criteria in Solid Tumors, and 16 patients (42%) had stabilization as their best response (58% disease control). The median overall survival was 7.7 months for all 38 patients, including 11.8 months for those who received repeated cycles (46% [6 of 13 patients] ≥1 year), with improved efficacy at

  8. Exclusive diffractive photon bremsstrahlung at the LHC

    NASA Astrophysics Data System (ADS)

    Lebiedowicz, Piotr; Szczurek, Antoni

    2013-06-01

    We calculate differential distributions for the pp→ppγ reaction at the LHC energy s=14TeV. We consider diffractive classical bremsstrahlung mechanisms including effects of the non-point-like nature of protons. In addition, we take into account (vector meson)-pomeron, photon-pion, and photon-pomeron exchange processes for the first time in the literature. Predictions for the total cross section and several observables related to these processes, e.g., differential distributions in pseudorapidities and transverse momenta of photons or protons are shown and discussed. The integrated diffractive bremsstrahlung cross section (Eγ>100GeV) is only of the order of μb. We try to identify regions of the phase space where one of the mechanisms dominates. The classical bremsstrahlung dominates at large forward/backward photon pseudorapidities, close to the pseudorapidities of scattered protons. In contrast, the photon-pomeron (pomeron-photon) mechanism dominates at midrapidities but the related cross section is rather small. In comparison the virtual-omega-rescattering mechanism contributes at smaller angles of photons (larger photon rapidities). Photons in the forward/backward region can be measured by the Zero Degree Calorimeters installed in experiments at the LHC while the midrapidity photons are difficult to measure (small cross section, small photon transverse momenta). Protons could be measured by the ALFA detector (ATLAS) or TOTEM detector at CMS. The exclusivity could be checked with the help of main central detectors.

  9. Anti-CD45 Radioimmunotherapy with 90Y but Not 177Lu Is Effective Treatment in a Syngeneic Murine Leukemia Model

    PubMed Central

    Orozco, Johnnie J.; Balkin, Ethan R.; Gooley, Ted A.; Kenoyer, Aimee; Hamlin, Donald K.; Wilbur, D. Scott; Fisher, Darrell R.; Hylarides, Mark D.; Shadman, Mazyar; Green, Damian J.; Gopal, Ajay K.; Press, Oliver W.; Pagel, John M.

    2014-01-01

    Radioimmunotherapy (RIT) for treatment of hematologic malignancies has primarily employed monoclonal antibodies (Ab) labeled with 131I or 90Y which have limitations, and alternative radionuclides are needed to facilitate wider adoption of RIT. We therefore compared the relative therapeutic efficacy and toxicity of anti-CD45 RIT employing 90Y and 177Lu in a syngeneic, disseminated murine myeloid leukemia (B6SJLF1/J) model. Biodistribution studies showed that both 90Y- and 177Lu-anti-murine CD45 Ab conjugates (DOTA-30F11) targeted hematologic tissues, as at 24 hours 48.8±21.2 and 156±14.6% injected dose per gram of tissue (% ID/g) of 90Y-DOTA-30F11 and 54.2±9.5 and 199±11.7% ID/g of 177Lu-DOTA-30F11 accumulated in bone marrow (BM) and spleen, respectively. However, 90Y-DOTA-30F11 RIT demonstrated a dose-dependent survival benefit: 60% of mice treated with 300 µCi 90Y-DOTA-30F11 lived over 180 days after therapy, and mice treated with 100 µCi 90Y-DOTA-30F11 had a median survival 66 days. 90Y-anti-CD45 RIT was associated with transient, mild myelotoxicity without hepatic or renal toxicity. Conversely, 177Lu- anti-CD45 RIT yielded no long-term survivors. Thus, 90Y was more effective than 177Lu for anti-CD45 RIT of AML in this murine leukemia model. PMID:25460570

  10. Treatment of lung tumor colonies with 90Y targeted to blood vessels: comparison with the alpha-particle emitter 213Bi.

    PubMed

    Kennel, S J; Stabin, M; Yoriyaz, H; Brechbiel, M; Mirzadeh, S

    1999-01-01

    An in vivo lung tumor model system for radioimmunotherapy of lung metastases was used to test the relative effectiveness of the vascular- targeted beta-particle emitter 90Y, and alpha-particle emitter, 213Bi. Yttrium-90 was shown to be stably bound by CHXa" DTPA-MAb 201B conjugates and delivered efficiently to lung tumor blood vessels. Dosimetry calculations indicated that the lung received 16.2 Gy/MBq from treatment with 90Y MAb 201B, which was a sevenfold greater absorbed dose than any other organ examined. Therapy was optimal for 90Y with 3 MBq injected. Bismuth-213 MAb 201B also delivered a similar absorbed dose (15Gy/MBq) to the lung. Yttrium-90 was found to be slightly more effective against larger tumors than 213Bi, consistent with the larger range of 2 MeV beta particles from 90Y than the 8 MeV alpha particles from 213Bi. Treatment of EMT-6 tumors growing in immunodeficient SCID mice with 90Y or 213Bi MAb 201 resulted in significant destruction of tumor colonies; however, 90Y MAb 201B was toxic for the SCID mice, inflicting acute lung damage. In another tumor model, IC-12 rat tracheal carcinoma growing in SCID mouse lungs, 90Y therapy was more effective than 213Bi at destroying lung tumors. However, 90Y MAb 201B toxicity for the lung limited any therapeutic effect. We conclude that, although vascular-targeted 90Y MAb can be an effective therapeutic agent, particularly for larger tumors, in this model system, acute damage to the lung may limit its application. PMID:10096515

  11. Hepatic Toxicity After Radioembolization of the Liver Using {sup 90}Y-Microspheres: Sequential Lobar Versus Whole Liver Approach

    SciTech Connect

    Seidensticker, Ricarda; Seidensticker, Max; Damm, Robert; Mohnike, Konrad; Schuette, Kerstin; Malfertheiner, Peter; Buskirk, Mark Van; Pech, Maciej; Amthauer, Holger; Ricke, Jens

    2012-10-15

    Purpose: {sup 90}Y-radioembolization (RE) is a promising technique for delivering high doses of radiation to liver tumors but may result in compromise of liver function. To gain further perspective, we evaluated the toxicity rates of sequential lobar versus 'whole liver' {sup 90}Y-radioembolization. Methods: Thirty-four patients with liver malignancy in noncirrhotic livers were included; {sup 90}Y-radioembolization was performed as either whole liver or sequential lobar treatment in 17 patients each. Standard clinical and liver specific laboratory parameters as well as MR imaging before treatment and at follow-up (6 and 12 weeks) after radioembolization were evaluated for toxicity using the Common Terminology Criteria for Adverse Events (CTCAE). Volumetry of the liver, tumor, and spleen and measurement of portal vein diameter also were performed. Results: Three months after whole liver RE, 14 liver-related grade 3/4 events were recorded versus 2 events after sequential lobar treatment (P < 0.05). Three patients treated with whole liver RE suffered from radioembolization-induced liver disease (REILD). Pathological increases in bilirubin at 3 months were observed for the whole liver group only (52.3 vs. 18.7 {mu}mol/l, P = 0.012). Total liver volume did not change significantly in either group, but shrinkage of the initially treated hepatic lobe with compensatory hypertrophy of the subsequently treated lobe was observed in the sequential lobar group (P < 0.05). Portal vein diameter increased significantly in whole liver-treated patients only (+17% vs. +6.6%, P = 0.043). Conclusions: Noncirrhotic patients undergoing sequential lobar radioembolization had less hepatic toxicity compared to whole liver embolization. The sequential approach should be the preferred strategy.

  12. Organ doses from hepatic radioembolization with 90Y, 153Sm, 166Ho and 177Lu: A Monte Carlo simulation study using Geant4

    NASA Astrophysics Data System (ADS)

    Hashikin, N. A. A.; Yeong, C. H.; Guatelli, S.; Abdullah, B. J. J.; Ng, K. H.; Malaroda, A.; Rosenfeld, A. B.; Perkins, A. C.

    2016-03-01

    90Y-radioembolization is a palliative treatment for liver cancer. 90Y decays via beta emission, making imaging difficult due to absence of gamma radiation. Since post-procedure imaging is crucial, several theranostic radionuclides have been explored as alternatives. However, exposures to gamma radiation throughout the treatment caused concern for the organs near the liver. Geant4 Monte Carlo simulation using MIRD Pamphlet 5 reference phantom was carried out. A spherical tumour with 4.3cm radius was modelled within the liver. 1.82GBq of 90Y sources were isotropically distributed within the tumour, with no extrahepatic shunting. The simulation was repeated with 153Sm, 166Ho and 177Lu. The estimated tumour doses for all radionuclides were 262.9Gy. Tumour dose equivalent to 1.82GBq 90Y can be achieved with 8.32, 5.83, and 4.44GBq for 153Sm, 166Ho and 177Lu, respectively. Normal liver doses by the other radionuclides were lower than 90Y, hence beneficial for normal tissue sparing. The organ doses from 153Sm and 177Lu were relatively higher due to higher gamma energy, but were still well below 1Gy. 166Ho, 177Lu and 153Sm offer useful gamma emission for post-procedure imaging. They show potential as 90Y substitutes, delivering comparable tumour doses, lower normal liver doses and other organs doses far below the tolerance limit.

  13. Phase II study of (90)Y Ibritumomab tiuxetan (Zevalin) in patients with previously untreated marginal zone lymphoma.

    PubMed

    Lossos, Izidore S; Fabregas, Jesus C; Koru-Sengul, Tulay; Miao, Feng; Goodman, Deborah; Serafini, Aldo N; Hosein, Peter J; Stefanovic, Alexandra; Rosenblatt, Joseph D; Hoffman, James E

    2015-06-01

    The best upfront therapy for patients with non-gastric extranodal marginal zone lymphomas (MZLs) is not defined. We assessed the safety and efficacy of radioimmunotherapy with (90)yttrium ((90)Y) ibritumomab tiuxetan as upfront therapy in MZL (NCT00453102). A total of 16 patients were enrolled, 81% with advanced-stage disease and 44% with bulky disease. The overall response rate (ORR) at 12 weeks post-therapy was 87.5% (90% confidence interval [CI]: 65.6-97.7%), including a complete response in eight (50%), complete response unconfirmed in one (6%) and partial response in five (31%) patients. With a median follow-up of 65.6 months (range 4.0-96.5), the median progression-free survival (PFS) was 47.6 months (range 4.0-93.3) and median overall survival (OS) was not reached. The 5-year PFS was 40% (90% CI: 19.9-59.5%) and 5-year OS was 71.8% (90% CI: 46.8-86.5%). Overall, (90)Y ibritumomab tiuxetan was well tolerated and led to long-term responses and PFS rates. PMID:25315074

  14. A new approach for dose calculation in targeted radionuclide therapy (TRT) based on collapsed cone superposition: validation with (90)Y.

    PubMed

    Sanchez-Garcia, Manuel; Gardin, Isabelle; Lebtahi, Rachida; Dieudonné, Arnaud

    2014-09-01

    To speed-up the absorbed dose (AD) computation while accounting for tissue heterogeneities, a Collapsed Cone (CC) superposition algorithm was developed and validated for (90)Y. The superposition was implemented with an Energy Deposition Kernel scaled with the radiological distance, along with CC acceleration. The validation relative to Monte Carlo simulations was performed on 6 phantoms involving soft tissue, lung and bone, a radioembolisation treatment and a simulated bone metastasis treatment. As a figure of merit, the relative AD difference (ΔAD) in low gradient regions (LGR), distance to agreement (DTA) in high gradient regions and the γ(1%,1 mm) criterion were used for the phantoms. Mean organ doses and γ(3%,3 mm) were used for the patient data. For the semi-infinite sources, ΔAD in LGR was below 1%. DTA was below 0.6 mm. All profiles verified the γ(1%,1 mm) criterion. For both clinical cases, mean doses differed by less than 1% for the considered organs and all profiles verified the γ(3%,3 mm). The calculation time was below 4 min on a single processor for CC superposition and 40 h on a 40 nodes cluster for MCNP (10(8) histories). Our results show that the CC superposition is a very promising alternative to MC for (90)Y dosimetry, while significantly reducing computation time. PMID:25097006

  15. A new approach for dose calculation in targeted radionuclide therapy (TRT) based on collapsed cone superposition: validation with 90Y

    NASA Astrophysics Data System (ADS)

    Sanchez-Garcia, Manuel; Gardin, Isabelle; Lebtahi, Rachida; Dieudonné, Arnaud

    2014-09-01

    To speed-up the absorbed dose (AD) computation while accounting for tissue heterogeneities, a Collapsed Cone (CC) superposition algorithm was developed and validated for 90Y. The superposition was implemented with an Energy Deposition Kernel scaled with the radiological distance, along with CC acceleration. The validation relative to Monte Carlo simulations was performed on 6 phantoms involving soft tissue, lung and bone, a radioembolisation treatment and a simulated bone metastasis treatment. As a figure of merit, the relative AD difference (ΔAD) in low gradient regions (LGR), distance to agreement (DTA) in high gradient regions and the γ(1%,1 mm) criterion were used for the phantoms. Mean organ doses and γ(3%,3 mm) were used for the patient data. For the semi-infinite sources, ΔAD in LGR was below 1%. DTA was below 0.6 mm. All profiles verified the γ(1%,1 mm) criterion. For both clinical cases, mean doses differed by less than 1% for the considered organs and all profiles verified the γ(3%,3 mm). The calculation time was below 4 min on a single processor for CC superposition and 40 h on a 40 nodes cluster for MCNP (108 histories). Our results show that the CC superposition is a very promising alternative to MC for 90Y dosimetry, while significantly reducing computation time.

  16. Dosimetry of a (90)Y-hydroxide liquid brachytherapy treatment approach to canine osteosarcoma using PET/CT.

    PubMed

    Zhou, Jien Jie; Gonzalez, Arnulfo; Lenox, Mark W; Fossum, Theresa W; Frank, R Keith; Simon, Jaime; Stearns, Stan; Ruoff, Catherine M; Wendt, Richard E; Akabani, Gamal

    2015-03-01

    A new treatment strategy based on direct injections of (90)Y-hydroxide into the tumor bed in dogs with osteosarcoma was studied. Direct injections of the radiopharmaceutical into the tumor bed were made according to a pretreatment plan established using (18)F-FDG images. Using a special drill, cannulas were inserted going through tissue, tumor and bone. Using these cannulas, direct injections of the radiopharmaceutical were made. The in vivo biodistribution of (90)Y-hydroxide and the anatomical tumor bed were imaged using a time-of-flight (TOF) PET/CT scanner. The material properties of the tissues were estimated from corresponding CT numbers using an electron-density calibration. Radiation absorbed dose estimates were calculated using Monte Carlo methods where the biodistribution of the pharmaceutical from PET images was sampled using a collapsing 3-D rejection technique. Dose distributions in the tumor bed and surrounding tissues were calculated, showing significant heterogeneity with multiple hot spots at injection sites. Dose volume histograms showed that approximately 33.9% of bone and tumor and 70.2% of bone marrow and trabecular bone received an absorbed dose over 200Gy; approximately 3.2% of bone and tumor and 31.0% of bone marrow and trabecular bone received a total dose of over 1000Gy. PMID:25638490

  17. Bremsstrahlung converter debris shields: test and analysis

    SciTech Connect

    Reedy, E.D. Jr.; Perry, F.C.

    1983-10-01

    Electron beam accelerators are commonly used to create bremsstrahlung x-rays for effects testing. Typically, the incident electron beam strikes a sandwich of three materials: (1) a conversion foil, (2) an electron scavenger, and (3) a debris shield. Several laboratories, including Sandia National Laboratories, are developing bremsstrahlung x-ray sources with much larger test areas (approx. 200 to 500 cm/sup 2/) than ever used before. Accordingly, the debris shield will be much larger than before and subject to loads which could cause shield failure. To prepare for this eventuality, a series of tests were run on the Naval Surface Weapons Center's Casino electron beam accelerator (approx. 1 MeV electrons, 100 ns FWHM pulse, 45 kJ beam energy). The primary goal of these tests was to measure the stress pulse which loads a debris shield. These measurements were made with carbon gages mounted on the back of the converter sandwich. At an electron beam fluence of about 1 kJ/cm/sup 2/, the measured peak compressive stress was typically in the 1 to 2 kbar range. Measured peak compressive stress scaled in a roughly linear manner with fluence level as the fluence level was increased to 10 kJ/cm/sup 2/. The duration of the compressive pulse was on the order of microseconds. In addition to the stress wave measurements, a limited number of tests were made to investigate the type of damage generated in several potential shield materials.

  18. Weibel instability due to inverse bremsstrahlung absorption

    SciTech Connect

    Bendib, A.; Bendib, K.,; Bendib, A.; Bendib, K.; Sid, A.,; Bendib, K.,

    1997-06-01

    A new Weibel source due to the inverse bremsstrahlung absorption is presented. It has been shown that in homogeneous plasmas, this mechanism may drive strong collisionless Weibel modes with growth rates of order of {gamma}{approximately}10{sup 11}s{sup {minus}1} and negligible group velocities. In the laser-produced plasmas, for short laser wavelengths ({lambda}{sub L}{lt}1{mu}m) and high laser fluxes (I{gt}10{sup 14}W/cm{sup 2}), this Weibel source is most efficient as the ones due to the heat flux and the plasma expansion. The useful scaling law of the convective e-foldings, with respect to the laser and the plasma parameters, is also derived. {copyright} {ital 1997} {ital The American Physical Society}

  19. Bremsstrahlung target optimization for reflex triodes

    SciTech Connect

    Swanekamp, S. B.; Weber, B. V.; Stephanakis, S. J.; Mosher, D.; Commisso, R. J.

    2008-08-15

    The anode (tantalum) foil thickness in a reflex triode was varied from 2.5 to 250 {mu}m to maximize the dose from bremsstrahlung produced by a 1 MV, 1 MA, 100 ns electron beam. Experiments and computer simulations show that the dose is maximized for a foil thickness of about 25 {mu}m, 1/18th of the electron range computed from the continuous slowing down approximation. For foils thicker than optimum, self-absorption in the foil attenuates 10-100 keV photons, reducing the dose. For foils thinner than optimum, the dose decreases as a result of electron migration to large radius. A simple formula that predicts the optimum thickness as a function of the beam current and voltage is derived that should be applicable to a large range of experimental parameters.

  20. Large-scale purification of 90Sr from nuclear waste materials for production of 90Y, a therapeutic medical radioisotope.

    PubMed

    Wester, Dennis W; Steele, Richard T; Rinehart, Donald E; DesChane, Jaquetta R; Carson, Katharine J; Rapko, Brian M; Tenforde, Thomas S

    2003-07-01

    A major limitation on the supply of the short-lived medical isotope 90Y (t1/2 = 64 h) is the available quantity of highly purified 90Sr generator material. A radiochemical production campaign was therefore undertaken to purify 1,500 Ci of 90Sr that had been isolated from fission waste materials. A series of alkaline precipitation steps removed all detectable traces of 137Cs, alpha emitters, and uranium and transuranic elements. Technical obstacles such as the buildup of gas pressure generated upon mixing large quantities of acid with solid 90Sr carbonate were overcome through safety features incorporated into the custom-built equipment used for 90Sr purification. Methods are described for analyzing the chemical and radiochemical purity of the final product and for accurately determining by gravimetry the quantities of 90Sr immobilized on stainless steel filters for future use. PMID:12878120

  1. Radioimmunotherapy of breast cancer metastases with alpha-particle emitter 225Ac: comparing efficacy with 213Bi and 90Y.

    PubMed

    Song, Hong; Hobbs, Robert F; Vajravelu, Ravy; Huso, David L; Esaias, Caroline; Apostolidis, Christos; Morgenstern, Alfred; Sgouros, George

    2009-12-01

    alpha-Particles are suitable to treat cancer micrometastases because of their short range and very high linear energy transfer. alpha-Particle emitter (213)Bi-based radioimmunotherapy has shown efficacy in a variety of metastatic animal cancer models, such as breast, ovarian, and prostate cancers. Its clinical implementation, however, is challenging due to the limited supply of (225)Ac, high technical requirement to prepare radioimmunoconjugate with very short half-life (T(1/2) = 45.6 min) on site, and prohibitive cost. In this study, we investigated the efficacy of the alpha-particle emitter (225)Ac, parent of (213)Bi, in a mouse model of breast cancer metastases. A single administration of (225)Ac (400 nCi)-labeled anti-rat HER-2/neu monoclonal antibody (7.16.4) completely eradicated breast cancer lung micrometastases in approximately 67% of HER-2/neu transgenic mice and led to long-term survival of these mice for up to 1 year. Treatment with (225)Ac-7.16.4 is significantly more effective than (213)Bi-7.16.4 (120 microCi; median survival, 61 days; P = 0.001) and (90)Y-7.16.4 (120 microCi; median survival, 50 days; P < 0.001) as well as untreated control (median survival, 41 days; P < 0.0001). Dosimetric analysis showed that (225)Ac-treated metastases received a total dose of 9.6 Gy, significantly higher than 2.0 Gy from (213)Bi and 2.4 Gy from (90)Y. Biodistribution studies revealed that (225)Ac daughters, (221)Fr and (213)Bi, accumulated in kidneys and probably contributed to the long-term renal toxicity observed in surviving mice. These data suggest (225)Ac-labeled anti-HER-2/neu monoclonal antibody could significantly prolong survival in HER-2/neu-positive metastatic breast cancer patients. PMID:19920193

  2. Separation of carrier-free {sup 90}Y from high level waste by extraction chromatographic technique using 2-ethylhexyl-2-ethylhexyl phosphonic acid (KSM-17)

    SciTech Connect

    Achuthan, P.V.; Dhami, P.S.; Kannan, R.; Gopalakrishnan, V.; Ramanujam, A.

    2000-01-01

    An extraction chromatographic technique has been developed for the separation of carrier-free {sup 90}Y from the {sup 90}Sr present in the high level waste (HLW) of the Purex process. When a Purex HLW solution in 2--3 M HNO{sub 3} is passed through a CMPO-Chromosorb-102 (CAC) column, all the trivalent, tetravalent, and hexavalent ions are sorbed. The effluent from this experiment, after adjusting the pH to 2 with NaOH, was passed through a 2-ethylhexyl-2-ethylhexyl phosphonic acid (KSM-17)-Chromosorb-102 (KSMC) extraction chromatographic column where only {sup 90}Y was sorbed. All the other ions ({sup 90}Sr, {sup 137}Cs, {sup 125}Sb, {sup 106}Ru, {sup 106}Rh, etc.) were washed off with dilute HNO{sub 3} (pH 2), and carrier-free {sup 90}Y was eluted with 0.5 M HNO{sub 3}. This technique can yield {sup 90}Y in mCi levels in pure form for medical applications. The {sup 90}Sr can be used repeatedly after allowing for {sup 90}Y buildup.

  3. Polarization transfer of bremsstrahlung arising from spin-polarized electrons.

    PubMed

    Märtin, R; Weber, G; Barday, R; Fritzsche, Y; Spillmann, U; Chen, W; DuBois, R D; Enders, J; Hegewald, M; Hess, S; Surzhykov, A; Thorn, D B; Trotsenko, S; Wagner, M; Winters, D F A; Yerokhin, V A; Stöhlker, Th

    2012-06-29

    We report on a study of the polarization transfer between transversely polarized incident electrons and the emitted x rays for electron-atom bremsstrahlung. By means of Compton polarimetry we performed for the first time an energy-differential measurement of the complete properties of bremsstrahlung emission related to linear polarization, i.e., the degree of linear polarization as well as the orientation of the polarization axis. For the high-energy end of the bremsstrahlung continuum the experimental results for both observables show a high sensitivity on the initial electron spin polarization and prove that the polarization orientation is virtually independent of the photon energy. PMID:23004992

  4. Relativistic Electron-Electron Bremsstrahlung in Fusion Plasma

    NASA Astrophysics Data System (ADS)

    Chen, Wen-Jia; Kawai, Norio; Kawamura, Takaichi; Maegauchi, Tetsuo; Narumi, Hajime

    1982-05-01

    Transition matrices and differential cross sections for electron-electron bremsstrahlung in relativistic energy region are calculated by the lowest-order perturbation theory of quantum electrodynamics. The bremsstrahlung spectra and emission rates are evaluated for relativistic Maxwellian plasma. The results are discussed in comparison with those obtained by non-relativistic and extreme-relativistic approximations and it is noted that the relativistic effect becomes appreciable above the order of 10 keV for the electron temperature.

  5. Molecular SPECT Imaging: An Overview

    PubMed Central

    Khalil, Magdy M.; Tremoleda, Jordi L.; Bayomy, Tamer B.; Gsell, Willy

    2011-01-01

    Molecular imaging has witnessed a tremendous change over the last decade. Growing interest and emphasis are placed on this specialized technology represented by developing new scanners, pharmaceutical drugs, diagnostic agents, new therapeutic regimens, and ultimately, significant improvement of patient health care. Single photon emission computed tomography (SPECT) and positron emission tomography (PET) have their signature on paving the way to molecular diagnostics and personalized medicine. The former will be the topic of the current paper where the authors address the current position of the molecular SPECT imaging among other imaging techniques, describing strengths and weaknesses, differences between SPECT and PET, and focusing on different SPECT designs and detection systems. Radiopharmaceutical compounds of clinical as well-preclinical interest have also been reviewed. Moreover, the last section covers several application, of μSPECT imaging in many areas of disease detection and diagnosis. PMID:21603240

  6. Analytic approximate radiation effects due to Bremsstrahlung

    SciTech Connect

    Ben-Zvi I.

    2012-02-01

    The purpose of this note is to provide analytic approximate expressions that can provide quick estimates of the various effects of the Bremsstrahlung radiation produced relatively low energy electrons, such as the dumping of the beam into the beam stop at the ERL or field emission in superconducting cavities. The purpose of this work is not to replace a dependable calculation or, better yet, a measurement under real conditions, but to provide a quick but approximate estimate for guidance purposes only. These effects include dose to personnel, ozone generation in the air volume exposed to the radiation, hydrogen generation in the beam dump water cooling system and radiation damage to near-by magnets. These expressions can be used for other purposes, but one should note that the electron beam energy range is limited. In these calculations the good range is from about 0.5 MeV to 10 MeV. To help in the application of this note, calculations are presented as a worked out example for the beam dump of the R&D Energy Recovery Linac.

  7. Radionuclide Therapy of Unresectable Tumors with AvidinOX and (90)Y-biotinDOTA: Tongue Cancer Paradigm.

    PubMed

    Albertoni, Claudio; Leoni, Barbara; Rosi, Antonio; D'Alessio, Valeria; Carollo, Valeria; Spagnoli, Luigi Giusto; van Echteld, Cees; De Santis, Rita

    2015-09-01

    Local treatment of unresectable tumors is challenging, particularly with radioactivity. Current practice relies on external beam irradiation or on a variety of medical devices for brachytherapy. Both approaches proved useful in controlling tumor growth, but are characterized by poor compliance of the patient, significant side-effects, high costs, and technological complexity, which hamper widespread use. The authors recently described a novel form of radionuclide therapy based on the oxidized form of avidin that, chemically reacting with tissue proteins, can secure radioactive biotin within the injected tissue, either when precomplexed or when taken from the blood stream after intravenous administration. AvidinOX-pretargeted (177)Lu-biotinDOTA ((177)Lu-ST2210) is currently under clinical investigation for the treatment of liver oligometastases from colorectal cancer (clinicaltrials.gov/NCT02053324). In the present work, the authors show that injected AvidinOX can link tissues of various natures such as prostate, kidney, breast, or brain and can react by contact with scraped tissues such as skin or urinary bladder. AvidinOX injected into human OSC19 tongue cancer masses orthotopically transplanted in nude mice takes up intravenously administered (90)Y-ST2210, which exerts significant antitumor activity, while preserving the integrity and functionality of the tongue. Present data confirm that AvidinOX-based radionuclide therapy is an innovative and promising approach for the local treatment of inoperable tumors. PMID:26167947

  8. Radionuclide Therapy of Unresectable Tumors with AvidinOX and 90Y-biotinDOTA: Tongue Cancer Paradigm

    PubMed Central

    Albertoni, Claudio; Leoni, Barbara; Rosi, Antonio; D'Alessio, Valeria; Carollo, Valeria; Spagnoli, Luigi Giusto; van Echteld, Cees

    2015-01-01

    Abstract Local treatment of unresectable tumors is challenging, particularly with radioactivity. Current practice relies on external beam irradiation or on a variety of medical devices for brachytherapy. Both approaches proved useful in controlling tumor growth, but are characterized by poor compliance of the patient, significant side-effects, high costs, and technological complexity, which hamper widespread use. The authors recently described a novel form of radionuclide therapy based on the oxidized form of avidin that, chemically reacting with tissue proteins, can secure radioactive biotin within the injected tissue, either when precomplexed or when taken from the blood stream after intravenous administration. AvidinOX-pretargeted 177Lu-biotinDOTA (177Lu-ST2210) is currently under clinical investigation for the treatment of liver oligometastases from colorectal cancer (clinicaltrials.gov/NCT02053324). In the present work, the authors show that injected AvidinOX can link tissues of various natures such as prostate, kidney, breast, or brain and can react by contact with scraped tissues such as skin or urinary bladder. AvidinOX injected into human OSC19 tongue cancer masses orthotopically transplanted in nude mice takes up intravenously administered 90Y-ST2210, which exerts significant antitumor activity, while preserving the integrity and functionality of the tongue. Present data confirm that AvidinOX-based radionuclide therapy is an innovative and promising approach for the local treatment of inoperable tumors. PMID:26167947

  9. Current status and future perspectives for yttrium-90 ((90)Y)-ibritumomab tiuxetan in stem cell transplantation for non-Hodgkin's lymphoma.

    PubMed

    Gisselbrecht, C; Bethge, W; Duarte, R F; Gianni, A M; Glass, B; Haioun, C; Martinelli, G; Nagler, A; Pettengell, R; Sureda, A; Tilly, H; Wilson, K

    2007-12-01

    Haematopoietic SCT is currently considered a therapeutic option mainly in relapsed or refractory non-Hodgkin's lymphoma (NHL) owing to high post-transplantation relapse rates and significant toxicity of conventional myeloablative conditioning for allogeneic SCT. Radiolabelled immunotherapy combines the benefits of monoclonal antibody targeting with therapeutic doses of radiation, and is a promising advance in the treatment of malignant lymphomas. It is now under investigation as a component of conditioning prior to SCT, with the aim of improving outcomes following SCT without increasing the toxicity of high-dose chemotherapy pre-transplant conditioning. An expert panel met at a European workshop in November 2006 to review the latest data on radiolabelled immunotherapy in the transplant setting, and its potential future directions, with a focus on (90)Y-ibritumomab tiuxetan. They reviewed data on the combination of standard/high/escalating dose (90)Y-ibritumomab tiuxetan with high-dose chemotherapy, and high/escalating dose (90)Y-ibritumomab tiuxetan as the sole myeloablative agent, prior to autologous SCT, and also (90)Y-ibritumomab tiuxetan as a component of reduced intensity conditioning prior to allogeneic SCT. The preliminary data are highly promising in terms of conditioning tolerability and patient outcomes following transplant; further phase II studies are now needed to consolidate these data and to investigate specific patient populations and NHL subtypes. PMID:17922042

  10. Sum rules for the polarization correlations in photoionization and bremsstrahlung

    NASA Astrophysics Data System (ADS)

    Pratt, R. H.; Müller, R. A.; Surzhykov, A.

    2016-05-01

    The polarization correlations in doubly differential cross sections are investigated for photoionization and ordinary bremsstrahlung. These correlations describe the polarization transfer between incident light and ejected photoelectrons as well as between an incoming electron beam and bremsstrahlung light, respectively. They are characterized by a set of seven real parameters Ci j. We show that the squares of these parameters are connected by simple "sum rules." These sum rules can be applied for both one-electron systems and also for atoms, if the latter are described within the independent particle approximation. In particular, they are exact in their simplest form (i) for the photoionization of K -, LI ,I I-, and MI ,I I-atomic shells, as well as (ii) for bremsstrahlung in which the electron is scattered into s1 /2 or p1 /2 states, as in the tip (bremsstrahlung) region. Detailed calculations are performed to verify the derived identities and to discuss their possible applications for the analysis of modern photoionization and bremsstrahlung experiments. In particular, we argue that the sum rules may help to determine the entire set of (significant) polarization correlations in the case when not all Ci j are available for experimental observation.

  11. Determination of the K absorption edge energy of Ho in element and its compounds using the bremsstrahlung technique

    NASA Astrophysics Data System (ADS)

    Niranjana, K. M.; Badiger, N. M.

    2013-05-01

    The K shell binding energies of Ho in element and in compounds Ho2O3 and HoF3 have been measured for the first time by adopting a novel method. The method involves a weak beta source, an external bremsstrahlung (EB) converter, element and compound targets and a high-resolution HPGe detector coupled to a 16K multichannel analyser. A spectrum of continuous EB photons, produced by the interaction of beta particles from a 90Sr-90Y radioactive source with an iron foil, is allowed to pass through the element and compound targets of Ho. The spectrum of transmitted EB photons is measured with a high-resolution HPGe detector spectrometer. The transmitted spectrum shows a sudden drop in intensity at K shell binding energy of the target. Such a sudden drop, which is essentially due to the onset of the K shell photoelectric effect, has been used to determine the K shell binding energy of Ho in element. The K shell binding energies of Ho in Ho2O3 and HoF3 compounds have also been determined using the same technique. From these data, the chemical shift in the K shell binding energy has been measured. It is found to be positive for Ho2O3 and negative for HoF3, indicating the dependence of the chemical shift on the crystal structure.

  12. Radiopharmaceuticals for SPECT cancer detection

    NASA Astrophysics Data System (ADS)

    Chernov, V. I.; Medvedeva, A. A.; Zelchan, R. V.; Sinilkin, I. G.; Stasyuk, E. S.; Larionova, L. A.; Slonimskaya, E. M.; Choynzonov, E. L.

    2016-08-01

    The purpose of the study was to assess the efficacy of single photon emission computed tomography (SPECT) with 199Tl and 99mTc-MIBI in the detection of breast, laryngeal and hypopharyngeal cancers. A total of 220 patients were included into the study: 120 patients with breast lesions (100 patients with breast cancer and 20 patients with benign breast tumors) and 100 patients with laryngeal/hypopharyngeal diseases (80 patients with laryngeal/hypopharyngeal cancer and 20 patients with benign laryngeal/hypopharyngeal lesions). No abnormal 199Tl uptake was seen in all patients with benign breast and laryngeal lesions, indicating a 100% specificity of 199Tl SPECT. In the breast cancer patients, the increased 199Tl uptake in the breast was visualized in 94.8% patients, 99mTc-MIBI—in 93.4% patients. The increased 199Tl uptake in axillary lymph nodes was detected in 60% patients, and 99mTc-MIBI—in 93.1% patients. In patients with laryngeal/hypopharyngeal cancer, the sensitivity of SPECT with 199Tl and 99mTc-MIBI was 95%. The 199Tl SPECT sensitivity in identification of regional lymph node metastases in the patients with laryngeal/hypopharyngeal cancer was 75% and the 99mTc-MIBI SPECT sensitivity was 17%. The data obtained showed that SPECT with 199Tl and 99mTc-MIBI can be used as one of the additional imaging methods in detection of tumors.

  13. Radiopharmaceuticals for SPECT Cancer Detection

    NASA Astrophysics Data System (ADS)

    Chernov, V. I.; Medvedeva, A. A.; Zelchan, R. V.; Sinilkin, I. G.; Stasyuk, E. S.; Larionova, L. A.; Slonimskaya, E. M.; Choynzonov, E. L.

    2016-06-01

    The purpose of the study was to assess the efficacy of single photon emission computed tomography (SPECT) with 199Tl and 99mTc-MIBI in the detection of breast, laryngeal and hypopharyngeal cancers. Materials and Methods: a total of 220 patients were included into the study. Of them, there were 120 patients with breast lesions (100 patients with breast cancer and 20 patients with benign breast tumors) and '00 patients with laryngeal/hypopharyngeal diseases (80 patients with laryngeal/hypopharyngeal cancer and 20 patients with benign laryngeal/hypopharyngeal lesions). Results: no abnormal 199Tl uptake was seen in all patients with benign breast and laryngeal lesions, indicating a 100% specificity of 199Tl SPECT. In breast cancer patients, increased 199Tl uptake in the breast was visualized in 94.8% patients, 99mTc-MIBI in 93.4% patients. Increased 199Tl uptake in axillary lymph nodes was detected in 60% patients and 99mTc-MIBI in 93.1% patients. In patients with laryngeal/hypopharyngeal cancer, sensitivity of SPECT with 199Tl and 99mTc-MIBI were 95%. The 199Tl SPECT sensitivity in identification of regional lymph node metastases in patients with laryngeal/hypopharyngeal cancer was 75% and the 99mTc-MIBI SPECT sensitivity was 17%. Conclusion: the data obtained show that SPECT with 199Tl and 99mTc-MIBI can be used as one of the additional imaging methods in detection of tumors.

  14. [PET and SPECT in epilepsy].

    PubMed

    Setoain, X; Carreño, M; Pavía, J; Martí-Fuster, B; Campos, F; Lomeña, F

    2014-01-01

    Epilepsy is one of the most frequent chronic neurological disorders, affecting 1-2% of the population. Patients with complex partial drug resistant episodes may benefit from a surgical treatment consisting in the excision of the epileptogenic area. Localization of the epileptogenic area was classically performed with video-EEG and magnetic resonance (MR). Recently, functional neuroimaging studies of Nuclear Medicine, positron emission tomography (PET) and single photon emission tomography (SPECT) have demonstrated their utility in the localization of the epileptogenic area prior to surgery. Ictal SPECT with brain perfusion tracers show an increase in blood flow in the initial ictal focus, while PET with (18)FDG demonstrates a decrease of glucose metabolism in the interictal functional deficit zone. In this review, the basic principles and methodological characteristics of the SPECT and PET in epilepsy are described. The ictal SPECT injection mechanism, different patterns of perfusion based on the time of ictal, postictal or interictal injection are detailed and the different diagnostic sensitivities of each one of these SPECT are reviewed. Different methods of analysis of the images with substraction and fusion systems with the MR are described. Similarly, the injection methodology, quantification and evaluation of the images of the PET in epilepsy are described. Finally, the main clinical indications of SPECT and PET in temporal and extratemporal epilepsy are detailed. PMID:24565567

  15. Polarization Bremsstrahlung radiation on a nanosphere in a dielectric

    NASA Astrophysics Data System (ADS)

    Astapenko, V. A.

    2011-11-01

    Within the limits of a new approach based on the Mie scattering theory, polarization bremsstrahlung radiation (PBR), arising during electron scattering on a metallic nanosphere with radius from 10 to 100 nm placed in a dielectric medium is theoretically investigated. The spectral range close to the plasmon resonance is considered, where the contribution of the polarized channel to bremsstrahlung radiation dominates. Spectral, velocity, and angular PBR characteristics are calculated. The sensitivity of the PBR spectrum to the dielectric permittivity of the medium surrounding the nanosphere is demonstrated.

  16. 90Y-daclizumab, an anti-CD25 monoclonal antibody, provided responses in 50% of patients with relapsed Hodgkin’s lymphoma

    PubMed Central

    Janik, John E.; Morris, John C.; O’Mahony, Deirdre; Pittaluga, Stefania; Jaffe, Elaine S.; Redon, Christophe E.; Bonner, William M.; Brechbiel, Martin W.; Paik, Chang H.; Whatley, Millie; Chen, Clara; Lee, Jae-Ho; Fleisher, Thomas A.; Brown, Maggie; White, Jeffrey D.; Stewart, Donn M.; Fioravanti, Suzanne; Lee, Cathryn C.; Goldman, Carolyn K.; Bryant, Bonita R.; Junghans, Richard P.; Carrasquillo, Jorge A.; Worthy, Tat’Yana; Corcoran, Erin; Conlon, Kevin C.; Waldmann, Thomas A.

    2015-01-01

    Despite significant advances in the treatment of Hodgkin’s lymphoma (HL), a significant proportion of patients will not respond or will subsequently relapse. We identified CD25, the IL-2 receptor alpha subunit, as a favorable target for systemic radioimmunotherapy of HL. The scientific basis for the clinical trial was that, although most normal cells with exception of Treg cells do not express CD25, it is expressed by a minority of Reed–Sternberg cells and by most polyclonal T cells rosetting around Reed–Sternberg cells. Forty-six patients with refractory and relapsed HL were evaluated with up to seven i.v. infusions of the radiolabeled anti-CD25 antibody 90Y-daclizumab. 90Y provides strong β emissions that kill tumor cells at a distance by a crossfire effect. In 46 evaluable HL patients treated with 90Y-daclizumab there were 14 complete responses and nine partial responses; 14 patients had stable disease, and nine progressed. Responses were observed both in patients whose Reed–Sternberg cells expressed CD25 and in those whose neoplastic cells were CD25− provided that associated rosetting T cells expressed CD25. As assessed using phosphorylated H2AX (γ-H2AX) as a bioindicator of the effects of radiation exposure, predominantly nonmalignant cells in the tumor microenvironment manifested DNA damage, as reflected by increased expression of γ-H2AX. Toxicities were transient bone-marrow suppression and myelodysplastic syndrome in six patients who had not been evaluated with bone-marrow karyotype analyses before therapy. In conclusion, repeated 90Y-daclizumab infusions directed predominantly toward nonmalignant T cells rosetting around Reed–Sternberg cells provided meaningful therapy for select HL patients. PMID:26438866

  17. Chemotherapy tolerance after radioimmunotherapy with 90Y-CC49 monoclonal antibody in patients with advanced non-small cell lung cancer: clinical effects and hematologic toxicity.

    PubMed

    Robert, Francisco; Busby, Elizabeth M; LoBuglio, Albert F

    2003-06-01

    The purpose of this retrospective analysis was to evaluate the hematologic toxicity and clinical outcome of salvage chemotherapy following (90)Y-CC49 radioimmunotherapy (RIT) in patients with non-small cell lung cancer (NSCLC). Sixteen patients from a total of 37 who were enrolled in a phase I trial of (90)Y-CC49 monoclonal therapy were treated with post-RIT salvage chemotherapy at our institution. Five patients had received chest radiation therapy prior to RIT, and seven patients had prior chemotherapy. The majority of these patients were treated with doses of (90)Y of >/= 14 mCi/m(2) (8-20 mCi/m(2)), and four of them received concurrent 96-hour taxol infusion. The maximum tolerated dose of this study was exceeded at 17 mCi/m(2), and grade 4 thrombocytopenia/neutropenia were the dose-limiting toxicities. Twelve patients received one chemotherapy regimen as salvage therapy, and four patients had more than one regimen. Four patients (25%) experienced reversible grade 4 neutropenia, but no grade 4 thrombocytopenia was observed. Five patients had stable disease. The median survival from start of salvage therapy was 5.5 months. Our data suggest that therapy with RIT did not significantly affect survival of these patients. Taking into consideration the potential clinical relevance of integration of RIT with other treatment modalities, it is important to expand this clinical experience in order to support combined modality strategies. PMID:12954119

  18. Directionality of bremsstrahlung from relativistic electrons in solar flares

    NASA Technical Reports Server (NTRS)

    Dermer, C. D.; Ramaty, R.

    1985-01-01

    Angular and energy spectra of bremsstrahlung have been calculated from anisotropic electron distributions in solar flares. Results have been compared to observations of gamma-ray limb-brightening and to data on the variation of the gamma-ray spectrum with flare position on the sun.

  19. Large efficiency improvements in BEAMnrc using directional bremsstrahlung splitting

    SciTech Connect

    Kawrakow, I.; Rogers, D.W.O.; Walters, B.R.B.

    2004-10-01

    The introduction into the BEAMnrc code of a new variance reduction technique, called directional bremsstrahlung splitting (DBS), is described. DBS uses a combination of interaction splitting for bremsstrahlung, annihilation, Compton scattering, pair production and photoabsorption, and Russian Roulette to achieve a much better efficiency of photon beam treatment head simulations compared to the splitting techniques already available in BEAMnrc (selective bremsstrahlung splitting, SBS, and uniform bremsstrahlung splitting, UBS). In a simulated 6 MV photon beam (10x10 cm{sup 2} field) photon fluence efficiency in the beam using DBS is over 8 times higher than with optimized SBS and over 20 times higher than with UBS, with a similar improvement in electron fluence efficiency in the beam. Total dose efficiency in a central-axis depth-dose curve improves by a factor of 6.4 over SBS at all depths in the phantom. The performance of DBS depends on the details of the accelerator being simulated. At higher energies, the relative improvement in efficiency due to DBS decreases somewhat, but is still a factor of 3.5 improvement over SBS for total dose efficiency using DBS in a simulated 18 MV photon beam. Increasing the field size of the simulated 6 MV beam to 40x40 cm{sup 2} (broad beam) causes the relative efficiency improvement of DBS to decrease by a factor of {approx_equal}1.7 but is still up to 7 times more efficient than with SBS.

  20. Exact Bremsstrahlung Function in N=2 Superconformal Field Theories.

    PubMed

    Fiol, Bartomeu; Gerchkovitz, Efrat; Komargodski, Zohar

    2016-02-26

    We propose an exact formula for the energy radiated by an accelerating quark in N=2 superconformal theories in four dimensions. This formula reproduces the known bremsstrahlung function for N=4 theories and provides a prediction for all the perturbative and instanton corrections in N=2 theories. We perform a perturbative check of our proposal up to three loops. PMID:26967407

  1. Progress in BazookaSPECT

    PubMed Central

    Miller, Brian W.; Barber, H. Bradford; Furenlid, Lars R.; Moore, Stephen K.; Barrett, Harrison H.

    2010-01-01

    Recent progress on a high-resolution, photon-counting gamma-ray and x-ray imager called BazookaSPECT is presented. BazookaSPECT is an example of a new class of scintillation detectors based on integrating detectors such as CCD(charge-coupled device) or CMOS(complementary metal-oxide semiconductor) sensors. BazookaSPECT is unique in that it makes use of a scintillator in close proximity to a microchannel plate-based image intensifier for up-front optical amplification of scintillation light. We discuss progress made in bringing about compact BazookaSPECT modules and in real-time processing of event data using graphics processing units (GPUs). These advances are being implemented in the design of a high-resolution rodent brain imager called FastSPECT III. A key benefit of up-front optical gain is that any CCD/CMOS sensor can now be utilized for photon counting. We discuss the benefits and feasibility of using CMOS sensors as photon-counting detectors for digital radiography, with application in mammography and computed tomography (CT). We present as an appendix a formal method for comparing various photon-counting integrating detectors using objective statistical criteria. PMID:21297897

  2. SPECT imaging with resolution recovery

    SciTech Connect

    Bronnikov, A. V.

    2011-07-01

    Single-photon emission computed tomography (SPECT) is a method of choice for imaging spatial distributions of radioisotopes. Many applications of this method are found in nuclear industry, medicine, and biomedical research. We study mathematical modeling of a micro-SPECT system by using a point-spread function (PSF) and implement an OSEM-based iterative algorithm for image reconstruction with resolution recovery. Unlike other known implementations of the OSEM algorithm, we apply en efficient computation scheme based on a useful approximation of the PSF, which ensures relatively fast computations. The proposed approach can be applied with the data acquired with any type of collimators, including parallel-beam fan-beam, cone-beam and pinhole collimators. Experimental results obtained with a micro SPECT system demonstrate high efficiency of resolution recovery. (authors)

  3. A SPECT camera for combined MRI and SPECT for small animals

    NASA Astrophysics Data System (ADS)

    Meier, D.; Wagenaar, D. J.; Chen, S.; Xu, J.; Yu, J.; Tsui, B. M. W.

    2011-10-01

    We describe an MR-compatible SPECT camera for small animals. The SPECT camera system can be inserted into the bore of a state-of-the-art MRI system and allows researchers to acquire tomographic images from a mouse in-vivo with the MRI and the SPECT acquiring simultaneously. The SPECT system provides functional information, while MRI provides anatomical information. Until today it was impossible to operate conventional SPECT inside the MRI because of mutual interference. The new SPECT technology is based on semiconductor radiation sensors (CZT, ASICs), and it fits into conventional high field MRI systems with a minimum 12-cm bore size. The SPECT camera has an MR-compatible multi-pinhole collimator for mice with a Ø25-mm field-of-view. For the work reported here we assembled a prototype SPECT camera system and acquired SPECT and MRI data from radioactive sources and resolution phantoms using the camera outside and inside the MRI.

  4. A SPECT Camera for Combined MRI and SPECT for Small Animals.

    PubMed

    Meier, D; Wagenaar, D J; Chen, S; Xu, J; Yu, J; Tsui, B M W

    2011-10-01

    We describe an MR-compatible SPECT camera for small animals. The SPECT camera system can be inserted into the bore of a state-of-the-art MRI system and allows researchers to acquire tomographic images from a mouse in-vivo with the MRI and the SPECT acquiring simultaneously. The SPECT system provides functional information, while MRI provides anatomical information. Until today it was impossible to operate conventional SPECT inside the MRI because of mutual interference. The new SPECT technology is based on semiconductor radiation sensors (CZT, ASICs), and it fits into conventional high field MRI systems with a minimum 12-cm bore size. The SPECT camera has an MR-compatible multi-pinhole collimator for mice with a ø25-mm field-of-view. For the work reported here we assembled a prototype SPECT camera system and acquired SPECT and MRI data from radioactive sources and resolution phantoms using the camera outside and inside the MRI. PMID:21966076

  5. A SPECT Camera for Combined MRI and SPECT for Small Animals

    PubMed Central

    Meier, D.; Wagenaar, D. J.; Chen, S.; Xu, J.; Yu, J.; Tsui, B. M. W.

    2010-01-01

    We describe an MR-compatible SPECT camera for small animals. The SPECT camera system can be inserted into the bore of a state-of-the-art MRI system and allows researchers to acquire tomographic images from a mouse in-vivo with the MRI and the SPECT acquiring simultaneously. The SPECT system provides functional information, while MRI provides anatomical information. Until today it was impossible to operate conventional SPECT inside the MRI because of mutual interference. The new SPECT technology is based on semiconductor radiation sensors (CZT, ASICs), and it fits into conventional high field MRI systems with a minimum 12-cm bore size. The SPECT camera has an MR-compatible multi-pinhole collimator for mice with a ø25-mm field-of-view. For the work reported here we assembled a prototype SPECT camera system and acquired SPECT and MRI data from radioactive sources and resolution phantoms using the camera outside and inside the MRI. PMID:21966076

  6. Time evolution of bremsstrahlung and ion production of an electron cyclotron resonance ion source

    SciTech Connect

    Tarvainen, Ollie; Ropponen, Tommi; Jones, Peter; Peura, Pauli

    2008-01-01

    Bremsstrahlung radiation measurement is one of the most commonly used plasma diagnostics methods. Most of the bremsstrahlung measurements with electron cyclotron resonance (ECR) ion sources have been performed in continuous operation mode yielding information only on the steady state bremsstrahlung emission. This article describes the results of bremsstrahlung and ion current measurement with the JYFL 14 GHz ECRIS operated in pulsed mode. The experiments reveal information about the bremsstrahlung radiation in plasma conditions before reaching the equilibrium. The time scale of bremsstrahlung production is compared to ion production time scale for different charge states. The bremsstrahlung data is presented with 2 millisecond time intervals as a function of neutral gas pressure and microwave power. Data from hundreds of microwave pulses is combined in order to have a sufficient amount of events at each time step. The relevant plasma physics phenomena during both, the leading and the trailing edge of the RF pulse, are discussed.

  7. Direct satellite observations on bremsstrahlung radiation as a technique to investigate its role in meteorological processes

    NASA Technical Reports Server (NTRS)

    Johnson, R. G.; Imhof, W. L.

    1975-01-01

    It was suggested that bremsstrahlung radiation associated with strong auroras (in turn associated with geomagnetic disturbances) may cause increased ionization near the 300-millibar level, which, in turn, leads to the formation of cirrus clouds. These clouds could modify the outgoing black body radiation rates and influence weather patterns. The first satellite observations on bremsstrahlung radiation produced in the atmosphere by precipitating energetic electrons are discussed. This type of observation affords the possibility of directly monitoring the bremsstrahlung energy input to the lower atmosphere over large segments of earth and at frequent intervals. Detailed measurements on the spatial and energy distributions of the bremsstrahlung radiation are feasible with present techniques, and satellite data on widespread bremsstrahlung events are presented and discussed. From comparison of the ion production rates from cosmic rays with those calculated from bremsstrahlung from precipitating energetic electrons, it is concluded that bremsstrahlung radiation is a negligible contributor to the ionization near the 300-millibar level.

  8. Evaluation of Beta-Absorbed Fractions in a Mouse Model for 90Y, 188Re, 166Ho, 149Pm, 64Cu, and 177Lu Radionuclides

    SciTech Connect

    Miller, William H.; Hartmann-Siantar, Christine; Fisher, Darrell R.; Descalle, Marie-Anne; Daly, Tom; Lehmann, Joerg; Lewis, Michael R.; Hoffman, Timothy J.; Smith, Jeff; Situ, Peter D.; Volkert, Wynn A.

    2005-08-01

    Several short-lived, high-energy beta emitters are being proposed as the radionuclide components for molecular-targeted potential cancer therapeutic agents. The laboratory mice used to determine the efficacy of these new agents have organs that are relatively small compared to the ranges of these high-energy particles. The dosimetry model developed by Hui et al. was extended to provide realistic beta-dose estimates for organs in mice that received therapeutic radiopharmaceuticals containing 90Y, 188Re, 166Ho, 149Pm, 64Cu, and 177 Lu. Major organs in this model included the liver, spleen, kidneys, lungs, heart, stomach, small and large bowel, thyroid, pancreas, bone, marrow, carcass, and a 0.025-g tumor. The study as reported in this paper verifies their results for 90Y and extends them by using their organ geometry factors combined with newly calculated organ self-absorbed fractions from PEREGRINE and MCNP. PEREGRINE and MCNP agree to within 8% for the worst-case organ with average differences (averaged over all organs) decreasing from 5% for 90Y to 1% for 177Lu. When used with typical biodistribution data, the three different models predict doses that are in agreement to within 5% for the worst-case organ. The beta-absorbed fractions and cross-organ-deposited energy provided in this paper can be used by researchers to predict mouse-organ doses and should contribute to an improved understanding of the relationship between dose and radiation toxicity in mouse models where use of these isotopes is favorable.

  9. Carcinoid crisis induced by receptor radionuclide therapy with 90Y-DOTATOC in a case of liver metastases from bronchial neuroendocrine tumor (atypical carcinoid).

    PubMed

    Davì, M V; Bodei, L; Francia, G; Bartolomei, M; Oliani, C; Scilanga, L; Reghellin, D; Falconi, M; Paganelli, G; Lo Cascio, V; Ferdeghini, M

    2006-06-01

    SS receptors are overexpressed in many tumors, mainly of neuroendocrine origin, thus enabling the treatment with SS analogs. The clinical experience of receptor radionuclide therapy with the new analog [90Y-DOTA0-Tyr3 ]-octreotide [90Y-DOTATOC] has been developed over the last decade and is gaining a pivotal role in the therapeutic workout of these tumors. It is well known that some procedures performed in diagnostic and therapeutic management of endocrine tumors, such as agobiopsy and hepatic chemoembolization, can be associated with the occurrence of symptoms related to the release of vasoactive amines and/or hormonal peptides from tumor cell lysis. This is the first report of a severe carcinoid crisis developed after receptor radionuclide therapy with 90Y-DOTATOC administered in a patient affected by liver metastases from bronchial neuroendocrine tumor (atypical carcinoid). Despite protection with H1 receptor antagonists, octreotide and corticosteroids, few days after the therapy the patient complained of persistent flushing of the face and upper trunk, severe labial and periocular oedema, diarrhoea and loss of appetite. These symptoms increased and required new hospitalisation. The patient received iv infusion of octreotide associated with H1 and H2 receptor antagonists and corticosteroid therapy, which induced symptom remission within few days. The case here reported confirms that radionuclide therapy is highly effective in determining early rupture of metastatic tissue and also suggests that pre-medication should be implemented before the radiopeptide administration associated with a close monitoring of the patient in the following days. PMID:16840837

  10. Growth hormone-secreting macroadenoma of the pituitary gland successfully treated with the radiolabeled somatostatin analog (90)Y-DOTATATE: case report.

    PubMed

    Waligórska-Stachura, Joanna; Gut, Paweł; Sawicka-Gutaj, Nadia; Liebert, Włodzimierz; Gryczyńska, Maria; Baszko-Błaszyk, Daria; Blanco-Gangoo, Al Ricardo; Ruchała, Marek

    2016-08-01

    Pituitary tumors causing acromegaly are usually macroadenomas at the time of diagnosis, and they can grow aggressively, infiltrating surrounding tissues. Difficulty in achieving complete tumor removal at surgery can lead toward a strong tendency for recurrence, making it necessary to consider a means of treatment other than those currently used such as somatostatin analogs (SSAs), growth hormone (GH) receptor antagonist, surgical removal, and radiotherapy. The purpose of this paper is to describe a patient diagnosed with an aggressive, giant GH-secreting tumor refractory to medical therapy but ultimately treated with the radiolabeled somatostatin analog (90)Y-DOTATATE. A 26-year-old male with an invasive macroadenoma of the pituitary gland (5.6 × 2.5 × 3.6 cm) and biochemically confirmed acromegaly underwent 2 partial tumor resections: the first used the transsphenoidal approach and the second used the transcranial method. The patient received SSAs pre- and postoperatively. Because of the progression in pituitary tumor size, he underwent classic irradiation of the tumor (50 Gy). One and a half years later, the patient presented with clinically and biochemically active disease, and the tumor size was still 52 mm in diameter (height). Two neurosurgeons disqualified him from further surgical procedures. After confirming the presence of somatostatin receptors in the pituitary tumor by using (68)Ga-DOTATATE PET/CT, we treated the patient 4 times with an SSA bound with (90)Y-DOTATATE. After this treatment, the patient attained partial biochemical remission and a reduction in the tumor mass for the first time. Treatment with an SSA bound with (90)Y-DOTATATE may be a promising option for some aggressive GH-secreting pituitary adenomas when other methods have failed. PMID:26636388

  11. Evaluation of beta-absorbed fractions in a mouse model for 90Y, 188Re, 166Ho, 149Pm, 64Cu, and 177Lu radionuclides.

    PubMed

    Miller, William H; Hartmann-Siantar, Christine; Fisher, Darrell; Descalle, Marie-Anne; Daly, Tom; Lehmann, Joerg; Lewis, Michael R; Hoffman, Timothy; Smith, Jeff; Situ, Peter D; Volkert, Wynn A

    2005-08-01

    Several short-lived, high-energy beta emitters are being proposed as the radionuclide components for molecular- targeted potential cancer therapeutic agents. The laboratory mice used to determine the efficacy of these new agents have organs that are relatively small compared to the ranges of these high-energy particles. The dosimetry model developed by Hui et al. was extended to provide realistic beta-dose estimates for organs in mice that received therapeutic radiopharmaceuticals containing (90)Y, (188)Re, (166)Ho, (149)Pm, (64)Cu, and (177)Lu. Major organs in this model included the liver, spleen, kidneys, lungs, heart, stomach, small and large bowel, thyroid, pancreas, bone, marrow, carcass, and a 0.025-g tumor. The study as reported in this paper verifies their results for (90)Y and extends them by using their organ geometry factors combined with newly calculated organ self-absorbed fractions from PEREGRINE and MCNP. PEREGRINE and MCNP agree to within 8% for the worst-case organ with average differences (averaged over all organs) decreasing from 5% for (90)Y to 1% for (177)Lu. When used with typical biodistribution data, the three different models predict doses that are in agreement to within 5% for the worst-case organ. The beta-absorbed fractions and cross-organ-deposited energy provided in this paper can be used by researchers to predict mouse-organ doses and should contribute to an improved understanding of the relationship between dose and radiation toxicity in mouse models where use of these isotopes is favorable. PMID:16114992

  12. Pyclen Tri-n-butylphosphonate Ester as Potential Chelator for Targeted Radiotherapy: From Yttrium(III) Complexation to (90)Y Radiolabeling.

    PubMed

    Le Fur, Mariane; Beyler, Maryline; Lepareur, Nicolas; Fougère, Olivier; Platas-Iglesias, Carlos; Rousseaux, Olivier; Tripier, Raphaël

    2016-08-15

    The Y(3+) complex of PCTMB, the tri-n-butyl phosphonate ester of pyclen (3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene), was synthesized as well as its Ho(3+) and Lu(3+) analogues. X-ray diffraction analyses revealed isomorphous dimeric M2(PCTMB)2·9H2O (M = Y, Ho, Lu) structures that crystallize in the centrosymmetric P1̅ triclinic space group. (1)H NMR and UV studies in aqueous solutions indicated that Y(3+) complexation is fast, being quantitative in 167 min at pH 3.8 and in 13 min at pH 5.5 (25 °C, acetate buffer, I = 0.150 M, [Y(3+)] = [PCTMB] = 0.2 mM). (1)H NMR DOSY and photon correlation spectroscopy experiments evidenced the formation of aggregates in chloroform with a bimodal distribution that changes slightly with concentration (11-24 and 240-258 nm). The behavior of the acid-assisted dissociation of the complex of Y(3+) with PCTMB was studied under pseudo-first-order conditions, and the half-life of the [Y(PCTMB)] complex in 0.5 M HCl at 25 °C was found to be 37 min, a value that decreases to 2.6 min in 5 M HCl. The Y(3+) complex of PCTMB is thermodynamically very stable, with a stability constant of log KY-PCTMB = 19.49 and pY = 16.7 measured by potentiometry. (90)Y complexation studies revealed fast radiolabeling kinetics; optimal radiolabeling conditions were obtained for (90)Y in acetate medium, PCTMB at 10(-4) to 10(-2) M in acetate buffer pH = 4.75, 15 min at 45-60 °C. In vitro stability studies in human serum showed that [(90)Y(PCTMB)] is quite stable, with about 90% of the activity still in the form of the radiotracer at 24 h and 80% from 48 h to 72 h. A comparison with other ligands such as PCTA, DOTA, and DTPA already used for in vivo application shows that [(90)Y(PCTMB)] is an interesting lipophilic and neutral analogue of these reference chelates for therapeutic applications in aqueous and nonaqueous media. PMID:27486673

  13. A 90Y-labelled anti-ROBO1 monoclonal antibody exhibits antitumour activity against hepatocellular carcinoma xenografts during ROBO1-targeted radioimmunotherapy

    PubMed Central

    2014-01-01

    Background ROBO1 is a membrane protein that functions in axon guidance. ROBO1 contributes to tumour metastasis and angiogenesis and may have potential as a target protein of immunotherapy because ROBO1 is specifically expressed at high levels in hepatocellular carcinoma. In this study, we examined biodistribution and radioimmunotherapy (RIT) using a radioisotope-labelled anti-ROBO1 monoclonal antibody (MAb) against hepatocellular carcinoma models. Methods ROBO1-positive HepG2 human hepatocellular carcinoma xenograft nude mice were used in this study. We conjugated anti-ROBO1 MAb with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), and the conjugates were labelled with 111In and 90Y. To study biodistribution, the 111In-DOTA-anti-ROBO1 MAb was injected into HepG2 xenograft mice via the tail vein. To evaluate any antitumour effect, a RIT study was performed, and the 90Y-DOTA-anti-ROBO1 MAb was injected via the tail vein. Tumour volume, mouse weight, and blood cell count were periodically measured throughout the experiments. The tumours and organs of mice were collected, and a histopathological analysis was carried out. Results The tumour uptake of 111In-anti-ROBO1 MAb in HepG2 xenograft mice was 15.0% ± 0.69% injected dose per gram at 48 h after injection. Immunotherapy with cold-anti-ROBO1 MAb (70 μg) did not cause a significant antitumour effect. RIT with 6.7 MBq of 90Y-anti-ROBO1 MAb caused significant tumour growth suppression. Transient body weight loss and bone-marrow suppression were observed. Histopathological analyses of tumours revealed the fatal degeneration of tumour cells, significant reduction of the Ki-67 index, and an increase of the apoptosis index. Normal organs showed no significant injury, but a transient reduction of hematopoietic cells was observed in the spleen and in the sternal bone marrow. Conclusions These results suggest that RIT with 90Y-anti-ROBO1 MAb is a promising treatment for ROBO1-positive hepatocellular

  14. Simulation of the Focal Spot of the Accelerator Bremsstrahlung Radiation

    NASA Astrophysics Data System (ADS)

    Sorokin, V.; Bespalov, V.

    2016-06-01

    Testing of thick-walled objects by bremsstrahlung radiation (BR) is primarily performed via high-energy quanta. The testing parameters are specified by the focal spot size of the high-energy bremsstrahlung radiation. In determining the focal spot size, the high- energy BR portion cannot be experimentally separated from the low-energy BR to use high- energy quanta only. The patterns of BR focal spot formation have been investigated via statistical modeling of the radiation transfer in the target material. The distributions of BR quanta emitted by the target for different energies and emission angles under normal distribution of the accelerated electrons bombarding the target have been obtained, and the ratio of the distribution parameters has been determined.

  15. Neutrino-pair bremsstrahlung in a neutron star crust

    NASA Astrophysics Data System (ADS)

    Ofengeim, D. D.; Kaminker, A. D.; Yakovlev, D. G.

    2014-11-01

    Based on the formalism by Kaminker et al. (Astron. Astrophys., 343 (1999) 1009) we derive an analytic approximation for neutrino-pair bremsstrahlung emissivity due to scattering of electrons by atomic nuclei in a neutron star crust of any realistic composition. The emissivity is expressed through the generalized Coulomb logarithm which we fit by introducing an effective potential of electron-nucleus scattering. In addition, we study the conditions at which the neutrino bremsstrahlung in the crust is affected by strong magnetic fields. The results can be applied for modelling of many phenomena in neutron stars, such as thermal relaxation in young isolated neutron stars and in accreting neutron stars with overheated crust in soft X-ray transients.

  16. K shell parameters of some lanthanide elements using bremsstrahlung

    NASA Astrophysics Data System (ADS)

    Niranjana, K. M.; Badiger, N. M.

    2015-02-01

    The spectrum of external bremsstrahlung (EB) transmitted through Tb and Ho is measured using a HPGe detector spectrometer. A sudden drop in transmitted intensity at K shell binding energy has been used to determine the K shell photoelectric parameters. The unwanted characteristic K x-ray photons generated just below the K edge has been avoided by carrying out a separate experiment in the same geometry. The measured values of K shell parameters have been compared with FFAST values.

  17. Proposal for the New Bremsstrahlung Facility at the JINR

    SciTech Connect

    Belloni, F.; Kamanin, D. V.; Kuznetsova, E. A.; Rogov, A. D.

    2007-05-22

    The possibility to build up the channel at the electron accelerators of the JINR for performing the delicate experiments with bremsstrahlung is considered. The proposed facility is mostly aimed at study of photo-fission itself and on the neutron-rich isotopes far from stability produced in photo-fission. This paper is aimed at the modeling of the facility with the widely used transport codes.

  18. Filtering in SPECT Image Reconstruction

    PubMed Central

    Lyra, Maria; Ploussi, Agapi

    2011-01-01

    Single photon emission computed tomography (SPECT) imaging is widely implemented in nuclear medicine as its clinical role in the diagnosis and management of several diseases is, many times, very helpful (e.g., myocardium perfusion imaging). The quality of SPECT images are degraded by several factors such as noise because of the limited number of counts, attenuation, or scatter of photons. Image filtering is necessary to compensate these effects and, therefore, to improve image quality. The goal of filtering in tomographic images is to suppress statistical noise and simultaneously to preserve spatial resolution and contrast. The aim of this work is to describe the most widely used filters in SPECT applications and how these affect the image quality. The choice of the filter type, the cut-off frequency and the order is a major problem in clinical routine. In many clinical cases, information for specific parameters is not provided, and findings cannot be extrapolated to other similar SPECT imaging applications. A literature review for the determination of the mostly used filters in cardiac, brain, bone, liver, kidneys, and thyroid applications is also presented. As resulting from the overview, no filter is perfect, and the selection of the proper filters, most of the times, is done empirically. The standardization of image-processing results may limit the filter types for each SPECT examination to certain few filters and some of their parameters. Standardization, also, helps in reducing image processing time, as the filters and their parameters must be standardised before being put to clinical use. Commercial reconstruction software selections lead to comparable results interdepartmentally. The manufacturers normally supply default filters/parameters, but these may not be relevant in various clinical situations. After proper standardisation, it is possible to use many suitable filters or one optimal filter. PMID:21760768

  19. Loopy constraints on leptophilic dark matter and internal bremsstrahlung

    SciTech Connect

    Kopp, Joachim; Michaels, Lisa; Smirnov, Juri E-mail: lisa.michaels@mpi-hd.mpg.de

    2014-04-01

    A sharp and spatially extended peak in an astrophysical gamma ray spectrum would provide very strong evidence for the existence of dark matter (DM), given that there are no known astrophysical processes that could mimic such a signal. From the particle physics perspective, perhaps the simplest explanation for a gamma ray peak is internal bremsstrahlung in DM annihilation through a charged t-channel mediator η close in mass to the DM particle χ. Since DM annihilation to quarks is already tightly constrained in this scenario, we focus here on the leptophilic case. We compute the electromagnetic anapole and dipole moments that DM acquires at 1-loop, and we find an interesting enhancement of these moments if the DM particle and the mediator are close in mass. We constrain the DM anapole and dipole moments using direct detection data, and then translate these limits into bounds on the DM annihilation cross section. Our bounds are highly competitive with those from astrophysical gamma ray searches. In the second part of the paper, we derive complementary constraints on internal bremsstrahlung in DM annihilation using LEP mono-photon data, measurements of the anomalous magnetic moments of the electron and the muon, and searches for lepton flavor violation. We also comment on the impact of the internal bremsstrahlung scenario on the hyperfine splitting of true muonium.

  20. Scintillating fiber array for tagging post-bremsstrahlung electrons

    NASA Astrophysics Data System (ADS)

    Cole, Philip; Alef, Stefan; Reitz, Björn-Eric; Schmieden, Hartmut; Hannappel, Jürgen; Jude, Thomas; Sandri, Paolo Levi; BGO-OD Collaboration

    2016-03-01

    We seek to extract the kinematic fingerprints of baryon resonances by making use of a high-quality beam of linearly polarized photons at the BGO-OD experiment at ELSA (Bonn, German). We constructed a unique device for precisely determining the degree of polarization in the coherent bremsstrahlung peak. Deflection of post-bremsstrahlung electrons in the magnetic field of the photon tagger provides precise information on the energy and polarization of the bremsstrahlung photons. And thereby will constrain the overall kinematics of the final-state particles in all decay channels of the photoproduced baryon resonances. We designed, prototyped, built, calibrated, and have been operating a three-layered, multi-stranded, scintillating-fiber detector for ensuring the quality of the linearly polarization of the photon beam. The overlapping 2.00-mm scintillating fibers form an array giving ARGUS over 500 channels. The very befitting name harkens to the mythological all-seeing creature Argus Panoptes, the multi-eyed giant. Our work was supported through a Fulbright Scholarship Award and by the Deutsche Forschungsgemeinschaft through the Collaborative Research Center (Sonderforschungsbereich SFB/TR-16) of the universities in Bonn, Giessen and Bochum, Germany. NSF-PHY-1307340.

  1. Treatment Parameters and Outcome in 680 Treatments of Internal Radiation With Resin {sup 90}Y-Microspheres for Unresectable Hepatic Tumors

    SciTech Connect

    Kennedy, Andrew S. McNeillie, Patrick M.S.; Dezarn, William A.; Nutting, Charles; Sangro, Bruno; Wertman, Dan; Garafalo, Michael; Liu, David; Coldwell, Douglas; Savin, Michael; Jakobs, Tobias; Rose, Steven; Warner, Richard; Carter, Dennis; Sapareto, Stephen; Nag, Subir; Gulec, Seza; Calkins, Allison; Gates, Vanessa L.; Salem, Riad

    2009-08-01

    Purpose: Radioembolization (RE) using {sup 90}Y-microspheres is an effective and safe treatment for patients with unresectable liver malignancies. Radiation-induced liver disease (RILD) is rare after RE; however, greater understanding of radiation-related factors leading to serious liver toxicity is needed. Methods and Materials: Retrospective review of radiation parameters was performed. All data pertaining to demographics, tumor, radiation, and outcomes were analyzed for significance and dependencies to develop a predictive model for RILD. Toxicity was scored using the National Cancer Institute Common Toxicity Criteria Adverse Events Version 3.0 scale. Results: A total of 515 patients (287 men; 228 women) from 14 US and 2 EU centers underwent 680 separate RE treatments with resin {sup 90}Y-microspheres in 2003-2006. Multifactorial analyses identified factors related to toxicity, including activity (GBq) Selective Internal Radiation Therapy delivered (p < 0.0001), prescribed (GBq) activity (p < 0.0001), percentage of empiric activity (GBq) delivered (p < 0.0001), number of prior liver treatments (p < 0.0008), and medical center (p < 0.0001). The RILD was diagnosed in 28 of 680 treatments (4%), with 21 of 28 cases (75%) from one center, which used the empiric method. Conclusions: There was an association between the empiric method, percentage of calculated activity delivered to the patient, and the most severe toxicity, RILD. A predictive model for RILD is not yet possible given the large variance in these data.

  2. (Depth-dose curves of the beta reference fields (147)Pm, (85)Kr and (90)Sr/(90)Y produced by the beta secondary standard BSS2.

    PubMed

    Brunzendorf, Jens

    2012-08-01

    The most common reference fields in beta dosimetry are the ISO 6980 series 1 radiation fields produced by the beta secondary standard BSS2 and its predecessor BSS. These reference fields require sealed beta radiation sources ((147)Pm, (85)Kr or (90)Sr/(90)Y) in combination with a source-specific beam-flattening filter, and are defined only at a given distance from the source. Every radiation sources shipped with the BSS2 is sold with a calibration certificate of the Physikalisch-Technische Bundesanstalt. The calibration workflow also comprises regular depth-dose measurements. This work publishes complete depth-dose curves of the series 1 sources (147)Pm, (85)Kr and (90)Sr/(90)Y in ICRU tissue up to a depth of 11 mm,when all electrons are stopped. For this purpose, the individual depth-dose curves of all BSS2 sources calibrated so far have been determined, i.e. the complete datasets of all BSS2 beta sources have been re-evaluated. It includes 191 depth-dose curves of 116 different sources comprising more than 2200 data points in total. Appropriate analytical representations of the nuclide-specific depth-dose curves are provided for the first time. PMID:22267274

  3. Biomedical Imaging: SPECT and PET

    SciTech Connect

    Lecomte, Roger

    2007-11-26

    Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET) are non-invasive nuclear imaging techniques relying on the use of tomographic reconstruction methods to provide 3D representations of the distribution of radiolabeled molecules in vivo. Differences in the underlying physical principles determine the achievable spatial resolution, sensitivity, specificity and observation time span of these two imaging modalities. Their specific characteristics are described and the current technology developments and design tradeoffs are reviewed.

  4. The selection and performance of diamond radiators used in coherent bremsstrahlung experiments

    NASA Astrophysics Data System (ADS)

    Kellie, J. D.; Clive, P. J. M.; Yang, G. L.; Beck, R.; Evans, B. C.; Gordon, C.; Hall, C.; Harris, J. W.; Jones, R. T.; Laundy, D.; Livingston, K.; MacGregor, I. J. D.; McGeorge, J. C.; Melone, J.; Schmidt, A.; Slaven, P. A.; Vrcelj, R. M.; Watts, D.

    2005-06-01

    The bremsstrahlung emitted as a result of scattering electrons in thin diamond crystals provides a useful source of high energy photons for use in photonuclear experiments, since the coherent bremsstrahlung produced is linearly polarized. Techniques for selecting the most favorable diamonds have been investigated. These are optical polaroid analysis, X-ray topography and rocking curve measurements. The diamonds are characterized with a view to determining their performance as radiators, and bremsstrahlung spectra from a diamond radiator used at the Mainz MAMI-B facility are presented. The changes caused by high energy electrons to the crystal properties of the diamond and to the resulting coherent bremsstrahlung spectra are discussed.

  5. Organ volume estimation using SPECT

    SciTech Connect

    Zaidi, H.

    1996-06-01

    Knowledge of in vivo thyroid volume has both diagnostic and therapeutic importance and could lead to a more precise quantification of absolute activity contained in the thyroid gland. In order to improve single-photon emission computed tomography (SPECT) quantitation, attenuation correction was performed according to Chang`s algorithm. The dual window method was used for scatter subtraction. The author used a Monte Carlo simulation of the SPECT system to accurately determine the scatter multiplier factor k. Volume estimation using SPECT was performed by summing up the volume elements (voxels) lying within the contour of the object, determined by a fixed threshold and the gray level histogram (GLH) method. Thyroid phantom and patient studies were performed and the influence of (1) fixed thresholding, (2) automatic thresholding, (3) attenuation, (4) scatter, and (5) reconstruction filter were investigated. This study shows that accurate volume estimation of the thyroid gland is feasible when accurate corrections are performed. The relative error is within 7% for the GLH method combined with attenuation and scatter corrections.

  6. Internal bremsstrahlung signatures in light of direct dark matter searches

    SciTech Connect

    Garny, Mathias; Ibarra, Alejandro; Pato, Miguel; Vogl, Stefan E-mail: ibarra@tum.de E-mail: stefan.vogl@tum.de

    2013-12-01

    Although proposed long ago, the search for internal bremsstrahlung signatures has only recently been made possible by the excellent energy resolution of ground-based and satellite-borne gamma-ray instruments. Here, we investigate thoroughly the current status of internal bremsstrahlung searches in light of the results of direct dark matter searches and in the framework of a minimal mass-degenerate scenario consisting of a Majorana dark matter particle that couples to a fermion and a scalar via a Yukawa coupling. The upper limits on the annihilation cross section set by Fermi-LAT and H.E.S.S. extend uninterrupted from tens of GeV up to tens of TeV and are rather insensitive to the mass degeneracy in the particle physics model. In contrast, direct searches are best in the moderate to low mass splitting regime, where XENON100 limits overshadow Fermi-LAT and H.E.S.S. up to TeV masses if dark matter couples to one of the light quarks. In our minimal scenario we examine carefully the prospects for GAMMA-400, CTA and XENON1T, all planned to come online in the near future, and find that: (a) CTA and XENON1T are fully complementary, with CTA most sensitive to multi-TeV masses and mass splittings around 10%, and XENON1T probing best small mass splittings up to TeV masses; and (b) current constraints from XENON100 already preclude the observation of any spectral feature with GAMMA-400 in spite of its impressive energy resolution, unless dark matter does not couple predominantly to light quarks. Finally, we point out that, unlike for direct searches, the possibility of detecting thermal relics in upcoming internal bremsstrahlung searches requires, depending on the concrete scenario, boost factors larger than 5–10.

  7. Study of 1s internal bremsstrahlung spectrum from 57Co

    NASA Astrophysics Data System (ADS)

    Raghavendra, M. K.; Azeez, Syed; Ramaswamy, C. R.; Umesh, T. K.; Gowda, Ramakrishna

    2002-07-01

    The internal bremsstrahlung contribution from the electron capture of 57Co has been measured in coincidence with K-X-ray of the residual atom. The end-point energy (EPE) is extracted from the data using the linearised Jauch plot. The transition energy obtained using the (EPE) is 842.7 keV, which is close to the value given by Audi and Wapstra. The measured intensity and shape factor from 300 to 600 keV are found to be in good agreement with the Glauber and Martin theory.

  8. Transplanckian Gravitational Bremsstrahlung in Post-Linear Formalism

    NASA Astrophysics Data System (ADS)

    Gal'tsov, Dmitry; Spirin, Pavel

    2015-01-01

    We report on calculation of classical ultrarelativistic gravitational bremsstrahlung in particle collisions in the ADD model with d toroidal extra dimensions using post-linear approximation. The radiation efficiency γ ≡ Erad/Einitial obtained can be expressed in terms of the Schwarzschild radius rS corresponding to the collision energy √ s, the impact parameter b and the center-of-mass Lorentz factor γcm as follows: ɛ = C_d ( {r_S /b} )^{3d + 3} × γ _{cm}^ν with some d-dependent power ν. This is larger than previously known estimates and is interpreted as indication on string radiative damping of transplanckian collisions.

  9. 90Y-ibritumomab tiuxetan radiotherapy as first-line therapy for early stage low-grade B-cell lymphomas, including bulky disease.

    PubMed

    Samaniego, Felipe; Berkova, Zuzana; Romaguera, Jorge E; Fowler, Nathan; Fanale, Michelle A; Pro, Barbara; Shah, Jatin J; McLaughlin, Peter; Sehgal, Lalit; Selvaraj, Vijairam; Braun, Frank K; Mathur, Rohit; Feng, Lei; Neelapu, Sattva S; Kwak, Larry W

    2014-10-01

    (90) Y-ibritumomab-tiuxetan ((90) YIT) was used as a first-line therapy for patients with early-stage follicular lymphoma (FL) or marginal zone B-cell lymphoma (MZL). Thirty-one patients were treated, with an overall 3-month response rate of 100% (68% complete response, 29% unconfirmed complete response and 3% partial response). At a median follow-up of 56 months, ten patients (32%) had disease relapse or progression. The progression-free rates at 3 and 5 years were lower in males, patients with FL, stage II disease and non-bulky disease, although they did not reach statistical significance. Grade 3-4 neutropenia, thrombocytopenia and anaemia were 61%, 35%, and 3%, respectively. (90) YIT was well tolerated, including in those patients over 60 years old, and achieved high response rates in patients with early-stage low-grade B-cell lymphomas. Bulky disease did not adversely affect tumour response. PMID:25040450

  10. A novel method for the preparation of large-area 90Sr/90Y sources for the calibration of hand contamination monitors.

    PubMed

    Kumar, Manoj; Gandhi, Shyamala S; Chakravarty, Rubel; Nuwad, J; Udhayakumar, J; Dash, Ashutosh

    2013-09-01

    This paper describes a method for the preparation of large-area (90)Sr/(90)Y polymer film sources for the calibration of hand contamination monitors. The process consists of solvent extraction of predictable quantity of (90)Sr into an organic solvent containing di-tert-butyl-cyclohexano-18-crown-6 (DCH18C6), formation of a polymeric solution of poly(methyl methacrylate) (PMMA), pouring the (90)Sr-embedded polymer solution over a surface of a defined area followed by evaporation to create a thin film and peeling-off of the radioactive PMMA film. Quality control tests of the radioactive films were carried out to ensure nonleachability, uniform distribution of activity and stability. Sources having 5kBq±428Bq were prepared using this method and routinely used for calibration of contamination monitors. PMID:23714116

  11. Efficacy of low-dose 90Sr-90Y therapy combined with topical application of 0.5% timolol maleate solution for the treatment of superficial infantile hemangiomas

    PubMed Central

    ZHU, HONG-JIAN; LIU, QINGHONG; DENG, XIAO-LI; GUAN, YAN-XING

    2015-01-01

    The aim of the present study was to investigate the clinical efficacy and safety of low-dose 90Sr-90Y therapy combined with the topical application of 0.5% timolol maleate solution for the treatment of superficial infantile hemangiomas (IHs). A total of 72 infants with hemangiomas were allocated at random into the observation group (17 cases aged ≤3 months, 20 cases aged >3 months) or the control group (15 cases aged ≤3 months, 20 cases aged >3 months). The observation group was treated with low-dose 90Sr-90Y combined with timolol, while the control group received an identical dose of 90Sr-90Y with physiological saline. Data were collected for statistical analysis, and treatment efficacy was compared between the two groups. In the observation group, 100% (37/37) of subjects exhibited an ‘excellent’ response to the treatment, while 94.1% (16/17) of patients aged ≤3 months and 85.0% (17/20) aged >3 months were classed as being cured. In the control group, the treatment was classed as ‘effective’ in 100% (35/35) of the subjects, while the excellent response rate was 86.7% (13/15) among the infants aged ≤3 months and 75.0% (15/20) among the infants aged >3 months. The ‘cure’ rates in the control group were 66.7% (10/15) and 60.0% (12/20) for the ≤3-month- and >3-month-old subjects, respectively. The excellent response and cure rates were notably higher in the observation group than those in the control group. Comparison between the two groups revealed a χ2 value of 13.90 (P<0.01) for excellent responses in subjects aged ≤3 months, while for patients aged >3 months the χ2 value was 28.57 (P<0.01). Analysis of the cure responses gave similar results [≤3 months, χ2=23.22 (P<0.01); >3 months, χ2=15.67 (P<0.01)]. At 3–4 months after the first course of treatment, the cure rate was 33.3% (11/33) in the observation group, which was significantly higher than the rate of 18.32% (4/22) in the control group (χ2=5.92, P<0.05). No serious adverse

  12. Long-term efficacy of (90)Y ibritumomab tiuxetan therapy in follicular non-Hodgkin lymphoma and health-related quality of life.

    PubMed

    Andrade-Campos, Marcio Miguel; Montes-Limón, Anel E; Soro-Alcubierre, Gloria; Grasa, José María; Lopez-Gómez, Luis; Baringo, Teresa; Giraldo, Pilar

    2014-12-01

    The aim of this study was to analyze the outcomes of 37 follicular lymphoma (FL) patients treated with (90)ytrium ibritumomab tiuxetan (90Y-IT), outside of clinical trial, according to protocol ISCRTN36210045, after ≥5 years follow-up to February 2014. Health-related quality of life (HRQoL) was evaluated with the SF-36, Spanish version, and compared with the general population of Spain. Patients had a mean age of 61.9 (range, 30-85) years and included 18 males. FLIPI, low: 25 (67.6 %), intermedium 9 (24.3 %), and low 3 (8.1 %). Previous therapy schedules >2: 48.6 % The median follow-up was 66 months, mean Time to Relapse (TTR) 71.3 months (58.8-83.8) median not reached. Thirty-four patients achieved complete response (91.8 %), and three no response. Mean overall survival: 82.3 months (71.6-92.9). Four patients presented with concomitant tumors (colon, breast, prostate, lung) after radioimmunotherapy, and three developed second primary neoplasms (esophagus, renal, and myelodysplastic syndrome in a relapsed patient who received fludarabine). Four of 10 deaths were related to lymphoma progression. Hematological toxicities were mild and easily managed. No patients required hospitalization. Negative scores were obtained in the physical and emotional roles items; however, the perception of general health and vitality were better than in the general population, with the best outcomes in non-relapsed patients. Radioimmunotherapy with 90Y-IT was safe and effective as long-term therapy in patients with FL. Early use of radioimmunotherapy could offer good, sustained responses with low toxicity over the long term and acceptable HRQoL. PMID:24985089

  13. In vivo Localization of 90Y- and 177Lu-Radioimmunoconjugates Using Cerenkov Luminescence Imaging in a Disseminated Murine Leukemia Model

    PubMed Central

    Balkin, Ethan R.; Kenoyer, Aimee; Orozco, Johnnie J.; Hernandez, Alexandra; Shadman, Mazyar; Fisher, Darrell R.; Green, Damian J.; Hylarides, Mark D.; Press, Oliver W.; Wilbur, D. Scott; Pagel, John M.

    2014-01-01

    Cerenkov radiation generated by positron-emitting radionuclides can be exploited for a molecular imaging technique known as Cerenkov Luminescence Imaging (CLI). Data have been limited, however, on the use of medium-to-high energy β-emitting radionuclides of interest for cancer imaging and treatment. We assessed the use of CLI as an adjunct to determine localization of radioimmunoconjugates to hematolymphoid tissues. Radiolabeled 177Lu- or 90Y-anti-CD45 antibody (Ab; DOTA-30F11) was administered by tail vein injection to athymic mice bearing disseminated murine myeloid leukemia with CLI images acquired at times afterward. Gamma counting of individual organs showed preferential uptake in CD45+ tissues with significant retention of radiolabeled Ab in sites of leukemia (spleen and bone marrow). This result was confirmed in CLI images with 1.35 × 105 ± 2.2 × 104 p/sec/cm2/sr and 3.45 × 103 ± 7.0 × 102 p/sec/cm2/sr for 90Y-DOTA-30F11 and 177Lu-DOTA-30F11, respectively, compared to undetectable signal for both radionuclides using the non-binding control Ab. Results showed that CLI allows for in vivo visualization of localized β-emissions. Pixel intensity variability resulted from differences in absorbed doses of the associated energies of the β-emitting radionuclide. Overall, our findings offer a preclinical proof of concept for the use of CLI techniques in tandem with currently available clinical diagnostic tools. PMID:25261237

  14. SPECT/CT and pulmonary embolism.

    PubMed

    Mortensen, Jann; Gutte, Henrik

    2014-05-01

    Acute pulmonary embolism (PE) is diagnosed either by ventilation/perfusion (V/P) scintigraphy or pulmonary CT angiography (CTPA). In recent years both techniques have improved. Many nuclear medicine centres have adopted the single photon emission CT (SPECT) technique as opposed to the planar technique for diagnosing PE. SPECT has been shown to have fewer indeterminate results and a higher diagnostic value. The latest improvement is the combination of a low-dose CT scan with a V/P SPECT scan in a hybrid tomograph. In a study comparing CTPA, planar scintigraphy and SPECT alone, SPECT/CT had the best diagnostic accuracy for PE. In addition, recent developments in the CTPA technique have made it possible to image the pulmonary arteries of the lungs in one breath-hold. This development is based on the change from a single-detector to multidetector CT technology with an increase in volume coverage per rotation and faster rotation. Furthermore, the dual energy CT technique is a promising modality that can provide functional imaging in combination with anatomical information. Newer high-end CT scanners and SPECT systems are able to visualize smaller subsegmental emboli. However, consensus is lacking regarding the clinical impact and treatment. In the present review, SPECT and SPECT in combination with low-dose CT, CTPA and dual energy CT are discussed in the context of diagnosing PE. PMID:24213621

  15. Bremsstrahlung of fast electrons in long air gaps

    SciTech Connect

    Oreshkin, E. V.; Barengolts, S. A.; Chaikovsky, S. A.; Oginov, A. V.; Shpakov, K. V.; Bogachenkov, V. A.

    2012-01-15

    The results of an experiment on discharges in long atmospheric pressure air gaps at a pulsed voltage of amplitude up to 800 kV and risetime 150-200 ns have been analyzed. In the experiment, a radiation pulse of photon energy >5 keV and duration 10-20 ns was observed. In analyzing the experimental data it was supposed that a streamer is a plasma protrusion whose surface is equipotential to the cathode surface. It has been shown that the x-ray pulse results from the switch of electrons into the mode of ''runaway'' from the head of anode-directed streamers. For the electrons injected in the electrode gap from the streamer head, conditions for their switching into the mode of continuous acceleration are realized due to the enhanced electric field at the head. The predicted maximum of the spectrum of the bremsstrahlung generated by the runaway electron beam is around 15 keV. The presence of a maximum in the bremsstrahlung spectrum is due to that the photons emitted by electrons are absorbed by atoms of the gas in which the discharge operate.

  16. Temperature diagnostics of ECR plasma by measurement of electron bremsstrahlung

    SciTech Connect

    Kasthurirangan, S.; Agnihotri, A. N.; Desai, C. A.; Tribedi, L. C.

    2012-07-15

    The x-ray bremsstrahlung spectrum emitted by the electron population in a 14.5 GHz ECR plasma source has been measured using a NaI(Tl) detector, and hence the electron temperature of the higher energy electron population in the plasma has been determined. The x-ray spectra for Ne and Ar gases have been systematically studied as a function of inlet gas pressure from 7 Multiplication-Sign 10{sup -7} mbar to 7 Multiplication-Sign 10{sup -5} mbar and for input microwave power {approx}1 W to {approx}300 W. At the highest input power and optimum pressure conditions, the end point bremsstrahlung energies are seen to reach {approx}700 keV. The estimated electron temperatures (T{sub e}) were found to be in the range 20 keV-80 keV. The T{sub e} is found to be peaking at a pressure of 1 Multiplication-Sign 10{sup -5} mbar for both gases. The T{sub e} is seen to increase with increasing input power in the intermediate power region, i.e., between 100 and 200 W, but shows different behaviour for different gases in the low and high power regions. Both gases show very weak dependence of electron temperature on inlet gas pressure, but the trends in each gas are different.

  17. Scalar dark matter models with significant internal bremsstrahlung

    SciTech Connect

    Giacchino, Federica; Tytgat, Michel H.G.; Lopez-Honorez, Laura E-mail: llopezho@vub.ac.be

    2013-10-01

    There has been interest recently on particle physics models that may give rise to sharp gamma ray spectral features from dark matter annihilation. Because dark matter is supposed to be electrically neutral, it is challenging to build weakly interacting massive particle models that may accommodate both a large cross section into gamma rays at, say, the Galactic center, and the right dark matter abundance. In this work, we consider the gamma ray signatures of a class of scalar dark matter models that interact with Standard Model dominantly through heavy vector-like fermions (the vector-like portal). We focus on a real scalar singlet S annihilating into lepton-antilepton pairs. Because this two-body final-state annihilation channel is d-wave suppressed in the chiral limit, σ{sub ff-bar}v∝v{sup 4}, we show that virtual internal bremsstrahlung emission of a gamma ray gives a large correction, both today and at the time of freeze-out. For the sake of comparison, we confront this scenario to the familiar case of a Majorana singlet annihilating into light lepton-antilepton pairs, and show that the virtual internal bremsstrahlung signal may be enhanced by a factor of (up to) two orders of magnitude. We discuss the scope and possible generalizations of the model.

  18. Molecular bremsstrahlung radiation at GHz frequencies in air

    NASA Astrophysics Data System (ADS)

    Al Samarai, Imen; Bérat, Corinne; Deligny, Olivier; Letessier-Selvon, Antoine; Montanet, François; Settimo, Mariangela; Stassi, Patrick

    2016-03-01

    A detection technique for ultra-high-energy cosmic rays, complementary to the fluorescence technique, would be the use of the molecular bremsstrahlung radiation emitted by low-energy ionization electrons left after the passage of the showers in the atmosphere. In this article, a detailed estimate of the spectral intensity of photons at ground level originating from this radiation is presented. The spectral intensity expected from the passage of the high-energy electrons of the cascade is also estimated. The absorption of the photons in the plasma of electrons and neutral molecules is shown to be negligible. The obtained spectral intensity is shown to be 2 ×1 0-21 W cm-2 GHz-1 at 10 km from the shower core for a vertical shower induced by a proton of 1 017.5 eV . In addition, a recent measurement of bremsstrahlung radiation in air at gigahertz frequencies from a beam of electrons produced at 95 keV by an electron gun is also discussed and reasonably reproduced by the model.

  19. Elastic photonuclear cross sections for bremsstrahlung from relativistic ions

    NASA Astrophysics Data System (ADS)

    Mikkelsen, Rune E.; Sørensen, Allan H.; Uggerhøj, Ulrik I.

    2016-04-01

    In this paper, we provide a procedure to calculate the bremsstrahlung spectrum for virtually any relativistic bare ion with charge 6e or beyond, Z ⩾ 6 , in ultraperipheral collisions with target nuclei. We apply the Weizsäcker-Williams method of virtual quanta to model the effect of the distribution of nuclear constituents on the interaction of the ion with the radiation target. This leads to a bremsstrahlung spectrum peaking at 2 γ times the energy of the giant dipole resonance (γ is the projectile energy in units of its rest energy). A central ingredient in the calculation is the cross section for elastic scattering of photons on the ion. This is only available in the literature for a few selected nuclei and, usually, only in a rather restricted parameter range. Hence we develop a procedure applicable for all Z ⩾ 6 to estimate the elastic scattering. The elastic cross section is obtained at low to moderate photon energies, somewhat beyond the giant dipole resonance, by means of the optical theorem, a dispersion relation, and data on the total absorption cross section. The cross section is continued at higher energies by invoking depletion due to loss of coherence in the scattering. Our procedure is intended for any ion where absorption data is available and for moderate to high energies, γ ≳ 10 .

  20. Parametric X-ray Radiation and Diffraction Bremsstrahlung from Moderately Relativistic Electrons in Pyrolytic Graphite Crystal

    SciTech Connect

    Vagner, A. R.; Potylitsyn, A. P.; Kuznecov, S. I.; Uglov, S. R.; Zabaev, V. N.; Razin, S. V.

    2007-11-26

    Spectral maxima of parametric X-ray radiation (PXR) and diffraction bremsstrahlung (DBS) from moderately relativistic electrons and bremsstrahlung interacting with crystal have been observed. The maxima position of PXR and DBS depends on the crystal orientation angle and corresponds to theoretical calculations.

  1. The AdaptiSPECT Imaging Aperture

    PubMed Central

    Chaix, Cécile; Moore, Jared W.; Van Holen, Roel; Barrett, Harrison H.; Furenlid, Lars R.

    2015-01-01

    In this paper, we present the imaging aperture of an adaptive SPECT imaging system being developed at the Center for Gamma Ray Imaging (AdaptiSPECT). AdaptiSPECT is designed to automatically change its configuration in response to preliminary data, in order to improve image quality for a particular task. In a traditional pinhole SPECT imaging system, the characteristics (magnification, resolution, field of view) are set by the geometry of the system, and any modification can be accomplished only by manually changing the collimator and the distance of the detector to the center of the field of view. Optimization of the imaging system for a specific task on a specific individual is therefore difficult. In an adaptive SPECT imaging system, on the other hand, the configuration can be conveniently changed under computer control. A key component of an adaptive SPECT system is its aperture. In this paper, we present the design, specifications, and fabrication of the adaptive pinhole aperture that will be used for AdaptiSPECT, as well as the controls that enable autonomous adaptation. PMID:27019577

  2. SPECT functional brain imaging. Technical considerations.

    PubMed

    Devous, M D

    1995-07-01

    The technical aspects of functional brain single-photon emission computed tomography (SPECT) imaging, referring primarily to the most common SPECT brain function measure--regional cerebral blood flow--are reviewed. SPECT images of regional cerebral blood flow are influenced by a number of factors unrelated to pathology, including tomographic quality, radiopharmaceuticals, environmental conditions at the time of radiotracer administration, characteristics of the subject (e.g., age, sex), image presentation, and image processing techniques. Modern SPECT scans yield excellent image quality, and instrumentation continues to improve. The armamentarium of regional cerebral blood flow and receptor radiopharmaceuticals is rapidly expanding. Standards regarding the environment for patient imaging and image presentation are emerging. However, there is still much to learn about the circumstances for performances and evaluation of SPECT functional brain imaging. Challenge tests, primarily established in cerebrovascular disease (i.e., the acetazolamide test), offer great promise in defining the extent and nature of disease, as well as predicting therapeutic responses. Clearly, SPECT brain imaging is a powerful clinical and research tool. However, SPECT will only achieve its full potential in the management of patients with cerebral pathology through close cooperation among members of the nuclear medicine, neurology, psychiatry, neurosurgery, and internal medicine specialties. PMID:7626833

  3. Integration of AdaptiSPECT, a small-animal adaptive SPECT imaging system

    PubMed Central

    Chaix, Cécile; Kovalsky, Stephen; Kosmider, Matthew; Barrett, Harrison H.; Furenlid, Lars R.

    2015-01-01

    AdaptiSPECT is a pre-clinical adaptive SPECT imaging system under final development at the Center for Gamma-ray Imaging. The system incorporates multiple adaptive features: an adaptive aperture, 16 detectors mounted on translational stages, and the ability to switch between a non-multiplexed and a multiplexed imaging configuration. In this paper, we review the design of AdaptiSPECT and its adaptive features. We then describe the on-going integration of the imaging system. PMID:26347197

  4. SPECT Imaging: Basics and New Trends

    NASA Astrophysics Data System (ADS)

    Hutton, Brian F.

    Single Photon Emission Computed Tomography (SPECT) is widely used as a means of imaging the distribution of administered radiotracers that have single-photon emission. The most widely used SPECT systems are based on the Anger gamma camera, usually involving dual detectors that rotate around the patient. Several factors affect the quality of SPECT images (e.g., resolution and noise) and the ability to perform absolute quantification (e.g., attenuation, scatter, motion, and resolution). There is a trend to introduce dual-modality systems and organ-specific systems, both developments that enhance diagnostic capability.

  5. 3D inpatient dose reconstruction from the PET-CT imaging of {sup 90}Y microspheres for metastatic cancer to the liver: Feasibility study

    SciTech Connect

    Fourkal, E.; Veltchev, I.; Lin, M.; Meyer, J.; Koren, S.; Doss, M.; Yu, J. Q.

    2013-08-15

    Purpose: The introduction of radioembolization with microspheres represents a significant step forward in the treatment of patients with metastatic disease to the liver. This technique uses semiempirical formulae based on body surface area or liver and target volumes to calculate the required total activity for a given patient. However, this treatment modality lacks extremely important information, which is the three-dimensional (3D) dose delivered by microspheres to different organs after their administration. The absence of this information dramatically limits the clinical efficacy of this modality, specifically the predictive power of the treatment. Therefore, the aim of this study is to develop a 3D dose calculation technique that is based on the PET imaging of the infused microspheres.Methods: The Fluka Monte Carlo code was used to calculate the voxel dose kernel for {sup 90}Y source with voxel size equal to that of the PET scan. The measured PET activity distribution was converted to total activity distribution for the subsequent convolution with the voxel dose kernel to obtain the 3D dose distribution. In addition, dose-volume histograms were generated to analyze the dose to the tumor and critical structures.Results: The 3D inpatient dose distribution can be reconstructed from the PET data of a patient scanned after the infusion of microspheres. A total of seven patients have been analyzed so far using the proposed reconstruction method. Four patients underwent treatment with SIR-Spheres for liver metastases from colorectal cancer and three patients were treated with Therasphere for hepatocellular cancer. A total of 14 target tumors were contoured on post-treatment PET-CT scans for dosimetric evaluation. Mean prescription activity was 1.7 GBq (range: 0.58–3.8 GBq). The resulting mean maximum measured dose to targets was 167 Gy (range: 71–311 Gy). Mean minimum dose to 70% of target (D70) was 68 Gy (range: 25–155 Gy). Mean minimum dose to 90% of target

  6. Laser radiography forming bremsstrahlung radiation to image an object

    DOEpatents

    Perry, Michael D.; Sefcik, Joseph A.

    2004-01-13

    A method of imaging an object by generating laser pulses with a short-pulse, high-power laser. When the laser pulse strikes a conductive target, bremsstrahlung radiation is generated such that hard ballistic high-energy electrons are formed to penetrate an object. A detector on the opposite side of the object detects these electrons. Since laser pulses are used to form the hard x-rays, multiple pulses can be used to image an object in motion, such as an exploding or compressing object, by using time gated detectors. Furthermore, the laser pulses can be directed down different tubes using mirrors and filters so that each laser pulse will image a different portion of the object.

  7. Vacuum Cherenkov radiation and bremsstrahlung from disformal couplings

    NASA Astrophysics Data System (ADS)

    van de Bruck, Carsten; Burrage, Clare; Morrice, Jack

    2016-08-01

    The simplest way to modify gravity is to extend the gravitational sector to include an additional scalar degree of freedom. The most general metric that can be built in such a theory includes disformal terms, so that standard model fields move on a metric which is the sum of the space time metric and a tensor constructed from first derivatives of the scalar. In such a theory gravitational waves and photons can propagate at different speeds, and these can in turn be different from the maximum speed limit for matter particles. In this work we show that disformal couplings can cause charged particles to emit Cherenkov radiation and bremsstrahlung apparently in vacuum, depending on the background evolution of the scalar field. We discuss the implications of this for observations of cosmic rays, and the constraints that arise for models of dark energy with disformal couplings.

  8. Positron-Annihilation Lifetime Spectroscopy using Electron Bremsstrahlung

    NASA Astrophysics Data System (ADS)

    Wagner, A.; Anwand, W.; Butterling, M.; Cowan, T. E.; Fiedler, F.; Fritz, F.; Kempe, M.; Krause-Rehberg, R.

    2015-06-01

    A new type of an intense source of positrons for materials research has been set up at the superconducting electron linear. The source employs hard X-rays from electron- bremsstrahlung production generating energetic electron-positron pairs inside the sample under investigation. CW-operation allows performing experiments with significantly reduced pile-up artefacts in the detectors compared to pulsed mode operation in conventional accelerators. The high-resolution timing of the accelerator with bunch lengths below 10 ps full width at half maximum (FWHM) allows positron annihilation lifetime spectroscopy (PALS) measurements with high time resolution. A single-component annihilation lifetime of Kaptonhas been measured as (381.3 ± 0.3) ps. Employing segmented detectors for the detection of both annihilation photons allows for the first time to perform a 4D tomographic reconstruction of the annihilation sites including the annihilation lifetime.

  9. Neutrino-pair bremsstrahlung from nucleon-nucleon scattering

    SciTech Connect

    Li, Yi; Liou, M. K.; Schreiber, W. M.; Gibson, B. F.

    2015-07-22

    Background: Neutrino-pair bremsstrahlung processes from nucleon-nucleon scattering ΝΝνν¯ (nnvv¯, ppvv¯, and npvv¯) have recently attracted attention in studies of neutrino emission in neutron stars, because of the implications for the neutron star cooling. The calculated ΝΝνν¯ emissivities within the neutron star environment are relatively insensitive to the two-nucleon dynamical model used in the calculations, but differ significantly from those obtained using an OPE model. Purpose: To investigate the free ΝΝνν¯ cross sections using a realistic nucleon-nucleon scattering amplitude, comparing the relative sizes of the cross sections for the three processes nnvv¯, ppvv¯, and npvv¯.

  10. The double copy: Bremsstrahlung and accelerating black holes

    NASA Astrophysics Data System (ADS)

    Luna, Andrés; Monteiro, Ricardo; Nicholso, Isobel; O'Connell, Donal; White, Chris D.

    2016-06-01

    Advances in our understanding of perturbation theory suggest the existence of a correspondence between classical general relativity and Yang-Mills theory. A concrete example of this correspondence, which is known as the double copy, was recently intro-duced for the case of stationary Kerr-Schild spacetimes. Building on this foundation, we examine the simple time-dependent case of an accelerating, radiating point source. The gravitational solution, which generalises the Schwarzschild solution, includes a non-trivial stress-energy tensor. This stress-energy tensor corresponds to a gauge theoretic current in the double copy. We interpret both of these sources as representing the radiative part of the field. Furthermore, in the simple example of Bremsstrahlung, we determine a scattering amplitude describing the radiation, maintaining the double copy throughout. Our results provide the strongest evidence yet that the classical double copy is directly related to the BCJ double copy for scattering amplitudes.

  11. Spectra and rates of bremsstrahlung neutrino emission in stars

    NASA Astrophysics Data System (ADS)

    Guo, Gang; Qian, Yong-Zhong

    2016-08-01

    We calculate the energy-differential rate for neutrino emission from electron-nucleus bremsstrahlung in stellar interiors taking into account the effects of electron screening and ionic correlations. We compare the energy-differential and the net rates, as well as the average ν¯e and ν¯x(x =μ ,τ ) energies, for this process with those for e± pair annihilation, plasmon decay, and photoneutrino emission over a wide range of temperature and density. We also compare our updated energy loss rates for the above thermal neutrino emission processes with the fitting formulas widely used in stellar evolution models and determine the temperature and density domain in which each process dominates. We discuss the implications of our results for detection of ν¯e from massive stars during their presupernova evolution and find that pair annihilation makes the predominant contribution to the signal from the thermal emission processes.

  12. Hydrodynamic Measurements of Bremsstrahlung Converter with X-ray Backlighting

    NASA Astrophysics Data System (ADS)

    Goldin, Fletcher; Caporaso, George; Chambers, Frank; Falabella, Steve; Guethlein, Gary; Ho, Darwin; McCarrick, James; Richardson, Roger; Sampayan, Steve; Trimble, Dave; Weir, John

    2002-11-01

    Performance of bremsstrahlung converters is under study using the 6 MeV, 2 kA, 50 ns electron beam produced by LLNL's Experimental Test Accelerator II. Critical for use in multi-pulse machines (e.g., DARHT-2) is the rate of target material expansion after e-beam heating (from the earlier pulses). Target designs are currently being developed using hydrodynamic calculations, but to verify our models, we directly measure density vs. time. A secondary X-ray source, with a pulse width (25 ns) short compared to target expansion timescale (1-10 ms) probes the target, and the fraction of X-rays transmitted implies an integrated material density at that time. Marching through various relative delay times in a sequence of shots then maps the rate of density decrease. Experimental technique will be discussed, and results will be compared to numerical simulation. Work performed for USDOE by UC/LLNL under contract W-7405-ENG-48.

  13. Quasiclassical description of bremsstrahlung accompanying {alpha} decay including quadrupole radiation

    SciTech Connect

    Jentschura, U. D.; Milstein, A. I.; Terekhov, I. S.; Boie, H.; Scheit, H.; Schwalm, D.

    2008-01-15

    We present a quasiclassical theory of {alpha} decay accompanied by bremsstrahlung with a special emphasis on the case of {sup 210}Po, with the aim of finding a unified description that incorporates both the radiation during the tunneling through the Coulomb wall and the finite energy E{sub {gamma}} of the radiated photon up to E{sub {gamma}}{approx}Q{sub {alpha}}/{radical}({eta}), where Q{sub {alpha}} is the {alpha}-decay Q-value and {eta} is the Sommerfeld parameter. The corrections with respect to previous quasiclassical investigations are found to be substantial, and excellent agreement with a full quantum mechanical treatment is achieved. Furthermore, we find that a dipole-quadrupole interference significantly changes the {alpha}-{gamma} angular correlation. We obtain good agreement between our theoretical predictions and experimental results.

  14. Laser-assisted bremsstrahlung for circular and linear polarization

    SciTech Connect

    Schnez, Stephan; Loetstedt, Erik; Jentschura, Ulrich D.; Keitel, Christoph H.

    2007-05-15

    We numerically evaluate the cross sections for spontaneous bremsstrahlung emission in a laser field for both circular and linear laser polarization, in a regime where the classical ponderomotive energies for the considered laser intensities are considerably larger than the rest mass of the electron. A fully relativistic quantum-electrodynamic approach using the Volkov solutions of an electron in an external field and Dirac-Volkov propagators for the intermediate electrons is applied. We compare circular to linear polarization and point out several interesting features of the laser-dressed cross sections. Regularizations in both electron and photon propagators are required. Specifically, imaginary mass and energy shifts of the electron must be implemented near resonances which correspond to Doppler-shifted harmonics of the laser frequency. We also introduce a screening to the Coulomb potential in order to avoid long-range Coulomb infinities at zero momentum transfer.

  15. Energy Calibration of the JLab Bremsstrahlung Tagging System

    SciTech Connect

    Stepan Stepanyan; S. Boyarinov; H. Egiyan; D. Dale; L. Guo; M. Gabrielyan; L. Gan; Ashot Gasparian; Bernhard Mecking; A. Teymurazyan; I. Nakagawa; Oleksandr Glamazdin; Michael Wood

    2007-03-01

    In this report, we present the energy calibration of the Hall B bremsstrahlung tagging system at the Thomas Jefferson National Accelerator Facility. The calibration was performed using a magnetic pair spectrometer. The tagged photon energy spectrum was measured in coincidence with e{sup +}e{sup -} pairs as a function of the pair spectrometer magnetic field. Taking advantage of the internal linearity of the pair spectrometer, the energy of the tagging system was calibrated at the level of {+-} 0.1% E{sub {gamma}}. The absolute energy scale was determined using the e{sup +}e{sup -} rate measurements close to the end-point of the photon spectrum. The energy variations across the full tagging range were found to be <3 MeV.

  16. Quantitative SPECT/CT: SPECT joins PET as a quantitative imaging modality.

    PubMed

    Bailey, Dale L; Willowson, Kathy P

    2014-05-01

    The introduction of combined modality single photon emission computed tomography (SPECT)/CT cameras has revived interest in quantitative SPECT. Schemes to mitigate the deleterious effects of photon attenuation and scattering in SPECT imaging have been developed over the last 30 years but have been held back by lack of ready access to data concerning the density of the body and photon transport, which we see as key to producing quantitative data. With X-ray CT data now routinely available, validations of techniques to produce quantitative SPECT reconstructions have been undertaken. While still suffering from inferior spatial resolution and sensitivity compared to positron emission tomography (PET) imaging, SPECT scans nevertheless can be produced that are as quantitative as PET scans. Routine corrections are applied for photon attenuation and scattering, resolution recovery, instrumental dead time, radioactive decay and cross-calibration to produce SPECT images in units of kBq.ml(-1). Though clinical applications of quantitative SPECT imaging are lacking due to the previous non-availability of accurately calibrated SPECT reconstructions, these are beginning to emerge as the community and industry focus on producing SPECT/CT systems that are intrinsically quantitative. PMID:24037503

  17. SPECT Myocardial Blood Flow Quantitation Concludes Equivocal Myocardial Perfusion SPECT Studies to Increase Diagnostic Benefits.

    PubMed

    Chen, Lung-Ching; Lin, Chih-Yuan; Chen, Ing-Jou; Ku, Chi-Tai; Chen, Yen-Kung; Hsu, Bailing

    2016-01-01

    Recently, myocardial blood flow quantitation with dynamic SPECT/CT has been reported to enhance the detection of coronary artery disease in human. This advance has created important clinical applications to coronary artery disease diagnosis and management for areas where myocardial perfusion PET tracers are not available. We present 2 clinical cases that undergone a combined test of 1-day rest/dipyridamole-stress dynamic SPECT and ECG-gated myocardial perfusion SPECT scans using an integrated imaging protocol and demonstrate that flow parameters are capable to conclude equivocal myocardial perfusion SPECT studies, therefore increasing diagnostic benefits to add value in making clinical decisions. PMID:26053731

  18. Inverse bremsstrahlung heating rate for dense plasmas in laser fields

    NASA Astrophysics Data System (ADS)

    Dey, R.; Roy, A. C.

    2013-07-01

    We report a theoretical analysis of inverse bremsstrahlung heating rate in the eikonal approximation. The present analysis is performed for a dense plasma using the screened electron-ion interaction potential for the ion charge state Zi = 1 and for both the weak and strong plasma screening cases. We have also compared the eikonal results with the first Born approximation (FBA) [M. Moll et al., New J. Phys. 14, 065010 (2012)] calculation. We find that the magnitudes of inverse bremsstrahlung heating rate within the eikonal approximation (EA) are larger than the FBA values in the weak screening case (κ = 0.03 a.u.) in a wide range of field strength for three different initial electron momenta (2, 3, and 4 a.u.). But for strong screening case (κ = 0.3 a.u.), the heating rates predicted by the two approximations do not differ much after reaching their maximum values. Furthermore, the individual contribution of photoemission and photoabsorption processes to heating rate is analysed for both the weak and strong screening cases. We find that the single photoemission and photoabsorption rates are the same throughout the field strength while the multiphoton absorption process dominates over the multiphoton emission process beyond the field strength ≈ 4×108 V/cm. The present study of the dependence of heating rate on the screening parameter ranging from 0.01 to 20 shows that whereas the heating rate predicted by the EA is greater than the FBA up to the screening parameter κ = 0.3 a.u., the two approximation methods yield results which are nearly identical beyond the above value.

  19. The influence of Bremsstrahlung induced photoionization for the streamer motion in various gas mixtures

    NASA Astrophysics Data System (ADS)

    Koehn, Christoph; Chanrion, Olivier; Neubert, Torsten

    2016-04-01

    Streamers, the beginning stages of electric discharges, evolve differently depending on their polarity and on the ambient gas composition. One of the well-known supporting mechanisms is "UVphotoionization" where, in air, excited nitrogen emits a UV photon subsequently ionizing oxygen. In pure nitrogen, however, this mechanism is suppressed because of the lack of oxygen; hence this mechanism strongly depends on the ambient gas medium. In this paper we introduce Bremsstrahlung induced photoionization: In the ambient electric field,electrons gain energy and produce Bremsstrahlung photons through the collision with the ambient gas molecules; similarly to "UV-photoionization", the Bremsstrahlung photons ionize the gas molecules and, as such, create electron populations detached from the initial electron patch. For the study of this process we implemented the electron-nucleus Bremsstrahlung process as well as the photoionization by individual photons into an already existing 2.5 D Monte Carlo particle code for the simulation of streamers. We initiated plasma patches of electrons and ions with varying initial electron energies and peak densities in different ambient fields in air and pure nitrogen. We will compare the temporal evolution of the electron densities as well as of the electric field with and without modelling Bremsstrahlung. In air we will test the influence of Bremsstrahlung induced photoionization against "UV-photoionization". We will show that the influence of Bremsstrahlung is negligible in air, but plays a significant role in pure nitrogen at standard temperature and pressure.

  20. Further measurements of bremsstrahlung from the insertion device beamlines of the Advanced Photon Source.

    SciTech Connect

    Job, P. K.

    1998-09-16

    Bremsstrahlung is produced in the Advanced Photon Source (APS) storage ring when the positron beam interacts with the storage-ring components or with the residual gas molecules in the storage-ring vacuum. The interaction of the positrons with the gas molecules occurs continually during storage ring operation. Bremsstrahlung is important at the insertion device straight sections because the contribution from each interaction adds up to produce a narrow mono-directional beam that travel down the beamlines. At the APS, with long storage ring beam straight paths (15.38 meters), gas bremsstrahlung in the insertion device beamlines can be significant. The preliminary results of the bremsstrahlung measurements in the insertion device beamlines of the APS was presented at SATIF3. This paper presents the results of further measurements at the two insertion device (ID) beamlines with higher statistics in the data collection. The beam current and the vacuum normalized bremsstrahlung power is fairly constant in a beamline for a given storage ring fill pattern, but may vary from beamline to beamline. The average bremsstrahlung power is measured as 118 {+-} 9 GeV/s/nT/mA at beamline 11 ID and as 36 {+-} 2 GeV/s/nT/mA at beamline 6 ID. These results, along with the results from the four previous independent bremsstrahlung measurements, enabled us to conclude upon the various reasons causing this variation.

  1. SPECT assay of radiolabeled monoclonal antibodies

    SciTech Connect

    Jaszczak, R.J.

    1992-02-01

    The long-term goal of this research project is to develop methods to improve the utility of single photon emission computed tomography (SPECI) to quantify the biodistribution of monoclonal antibodies (MoAbs) labeled with clinically relevant radionuclides ({sup 123}I, {sup 131}I, and {sup 111}In) and with another radionuclide,{sup 211}At, recently used in therapy. We describe here our progress in developing quantitative SPECT methodology for {sup 111}In and {sup 123}I. We have focused our recent research thrusts on the following aspects of SPECT: (1) The development of improved SPECT hardware, such as improved acquisition geometries. (2) The development of better reconstruction methods that provide accurate compensation for the physical factors that affect SPECT quantification. (3) The application of carefully designed simulations and experiments to validate our hardware and software approaches.

  2. Awake animal SPECT: Overview and initial results

    SciTech Connect

    Weisenberger, A G; Majewski, S; McKisson, J; Popov, V; Proffitt, J; Stolin, A; Baba, J S; Goddard, J S; Lee, S J; Smith, M F; Tsui, B; Pomper, M

    2009-02-01

    A SPECT / X-ray CT system configured at Johns Hopkins University to image the biodistribution of radiopharmaceuticals in unrestrained, un-anesthetized mice has been constructed and tested on awake mice. The system was built by Thomas Jefferson National Accelerator Facility and Oak Ridge National Laboratory. SPECT imaging is accomplished using two gamma cameras, 10 cm × 20 cm in size based on a 2 × 4 array of Hamamatsu H8500 flat panel position sensitive photomultiplier tubes. A real-time optical tracking system utilizing three infrared cameras provides time stamped pose data of an awake mouse head during a SPECT scan. The six degrees of freedom (three translational and three rotational) pose data are used for motion correction during 3-D tomographic list-mode iterative image reconstruction. SPECT reconstruction of awake, unrestrained mice with motion compensation for head movement has been accomplished.

  3. Single Photon Emission Computed Tomography (SPECT)

    MedlinePlus

    ... High Blood Pressure Tools & Resources Stroke More Single Photon Emission Computed Tomography (SPECT) Updated:Sep 11,2015 ... Persantine) or dobutamine. The tests may take between 2 and 2 1/2 hours. What happens after ...

  4. Monte Carlo Calculation of Radioimmunotherapy with 90Y-, 177Lu-, 131I-, 124I-, and 188Re-Nanoobjects: Choice of the Best Radionuclide for Solid Tumour Treatment by Using TCP and NTCP Concepts

    PubMed Central

    Lucas, S.; Feron, O.; Gallez, B.; Masereel, B.; Michiels, C.; Vander Borght, T.

    2015-01-01

    Radioimmunotherapy has shown that the use of monoclonal antibodies combined with a radioisotope like 131I or 90Y still remains ineffective for solid and radioresistant tumour treatment. Previous simulations have revealed that an increase in the number of 90Y labelled to each antibody or nanoobject could be a solution to improve treatment output. It now seems important to assess the treatment output and toxicity when radionuclides such as 90Y, 177Lu, 131I, 124I, and 188Re are used. Tumour control probability (TCP) and normal tissue complication probability (NTCP) curves versus the number of radionuclides per nanoobject were computed with MCNPX to evaluate treatment efficacy for solid tumours and to predict the incidence of surrounding side effects. Analyses were carried out for two solid tumour sizes of 0.5 and 1.0 cm radius and for nanoobject (i.e., a radiolabelled antibody) distributed uniformly or nonuniformly throughout a solid tumour (e.g., Non-small-cell-lung cancer (NSCLC)). 90Y and 188Re are the best candidates for solid tumour treatment when only one radionuclide is coupled to one carrier. Furthermore, regardless of the radionuclide properties, high values of TCP can be reached without toxicity if the number of radionuclides per nanoobject increases. PMID:26136812

  5. Photodissociation of p-process nuclei studied by bremsstrahlung-induced activation

    NASA Astrophysics Data System (ADS)

    Erhard, M.; Junghans, A. R.; Beyer, R.; Grosse, E.; Klug, J.; Kosev, K.; Nair, C.; Nankov, N.; Rusev, G.; Schilling, K. D.; Schwengner, R.; Wagner, A.

    2006-03-01

    A research program has been started to study experimentally the near-threshold photodissociation of nuclides in the chain of cosmic heavy-element production with bremsstrahlung from the ELBE accelerator. An important prerequisite for such studies is the good knowledge of the bremsstrahlung distribution which was determined by measuring the photodissociation of the deuteron and by comparison with model calculations. First data were obtained for the astrophysically important target nucleus 92Mo by observing the radioactive decay of the nuclides produced by bremsstrahlung irradiation at end-point energies between 11.8MeV and 14.0MeV. The results are compared to recent statistical model calculations.

  6. A Bremsstrahlung Spectrometer using k-edge and Differential Filters with Image plate dosimeters

    SciTech Connect

    Chen, C; Mackinnon, A; Beg, F; Chen, H; Key, M; King, J A; Link, A; MacPhee, A; Patel, P; Porkolab, M; Stephens, R; VanWoerkom, L; Akli, K; Freeman, R

    2008-05-02

    A Bremsstrahlung spectrometer using k-edge and differential filtering has been used with Image Plate dosimeters to measure the x-ray fluence from short-pulse laser/target interactions. An electron spectrometer in front of the Bremsstrahlung spectrometer deflects electrons from the x-ray line of sight and simultaneously measures the electron spectrum. The response functions were modeled with the Monte Carlo code Integrated Tiger Series 3.0 and the dosimeters calibrated with radioactive sources. Electron distributions with slope temperatures in the MeV range are inferred from the Bremsstrahlung spectra.

  7. A Bremsstrahlung spectrometer using k-edge and differential filters with image plate dosimeters

    SciTech Connect

    Chen, C. D.; Porkolab, M.; King, J. A.; Beg, F. N.; Key, M. H.; Chen, H.; Mackinnon, A. J.; MacPhee, A. G.; Patel, P. K.; Akli, K. U.; Stephens, R. B.; Freeman, R. R.; Link, A.; Van Woerkom, L. D.

    2008-10-15

    A Bremsstrahlung spectrometer using k-edge and differential filtering has been used with image plate dosimeters to measure the x-ray fluence from short-pulse laser/target interactions. An electron spectrometer in front of the Bremsstrahlung spectrometer deflects electrons from the x-ray line of sight and simultaneously measures the electron spectrum. The response functions were modeled with the Monte Carlo code INTEGRATED TIGER SERIES 3.0 and the dosimeters calibrated with radioactive sources. An electron distribution with a slope temperature of 1.3 MeV is inferred from the Bremsstrahlung spectra.

  8. Cerebral SPECT imaging: Impact on clinical management

    SciTech Connect

    Bloom, M.; Jacobs, S.; Pozniakof, T.

    1994-05-01

    Although cerebral SPECT has been reported to be of value in a variety of neurologic disorders, there is limited data available on the value of SPECT relative to clinical management decisions. The purpose of this study was to determine the effect of cerebral SPECT imaging on patient management. A total of 94 consecutive patients referred for clinical evaluation with brain SPECT were included in this study. Patients were assigned to one of nine groups depending on the clinical indication for the study. These groups included transient ischemia (16), stroke (20), dementia (18), seizures (5), hemorrhage (13), head trauma (6), arteriovenous malformations (6), encephalopathy (6) and a miscellaneous (4) group. All patients were injected with 99mTc HMPAO in doses ranging from 15 mCi to 22 mCi (555 MBq to 814 MBq) and scanned on a triple headed SPECT gamma camera. Two weeks after completion of the study, a standardized interview was conducted between the nuclear and referring physicians to determine if the SPECT findings contributed to an alteration in patient management. Overall, patient management was significantly altered in 47% of the cases referred. The greatest impact on patient management occurred in the group evaluated for transient ischemia, where a total of 13/16 (81%) of patients had their clinical management altered as a result of the cerebral SPECT findings. Clinical management was altered in 61% of patients referred for evaluation of dementia, 67% of patients evaluated for arteriovenous malformations, and 50% of patients with head trauma. In the remainder of the patients, alteration in clinical management ranged from 17% to 50% of patients. This study demonstrates the clinical utility of cerebral SPECT imaging since in a significant number of cases clinical management was altered as a result of the examination. Long term follow up will be necessary to determine patient outcome.

  9. Brain SPECT quantitation in clinical diagnosis

    SciTech Connect

    Hellman, R.S.

    1991-12-31

    Methods to quantitate SPECT data for clinical diagnosis should be chosen so that they take advantage of the lessons learned from PET data. This is particularly important because current SPECT high-resolution brain imaging systems now produce images that are similar in resolution to those generated by the last generation PET equipment (9 mm FWHM). These high-resolution SPECT systems make quantitation of SPECT more problematic than earlier. Methodology validated on low-resolution SPECT systems may no longer be valid for data obtained with the newer SPECT systems. For example, in patients with dementia, the ratio of parietal to cerebellar activity often was studied. However, with new instruments, the cerebellum appears very different: discrete regions are more apparent. The large cerebellar regions usually used with older instrumentation are of an inappropriate size for the new equipment. The normal range for any method of quantitation determined using older equipment probably changes for data obtained with new equipment. It is not surprising that Kim et al. in their simulations demonstrated that because of the finite resolution of imaging systems, the ability to measure pure function is limited, with {open_quotes}anatomy{close_quotes} and {open_quotes}function{close_quotes} coupled in a {open_quotes}complex nonlinear way{close_quotes}. 11 refs.

  10. SPECT assay of radiolabeled monoclonal antibodies

    SciTech Connect

    Jaszczak, R.J.

    1992-02-01

    The accurate determination of the biodistribution of radiolabeled monoclonal antibodies (MoAbs) is important for calculation of dosimetry and evaluation of pharmacokinetic variables such as antibody dose and route of administration. The hypothesis of this application is that the biodistribution of radiolabeled monoclonal antibodies (MoAbs) can be quantitatively determined using single photon emission computed tomography (SPECT). The major thrusts during the third year include the continued development and evaluation of improved 3D SPECT acquisition and reconstruction approaches to improve quantitative imaging of radiolabeled monoclonal antibodies (MoAbs), and the implementation and evaluation of algorithms to register serial SPECT image data sets, or to register 3D SPECT images with 3D image data sets acquired from positron emission tomography (PEI) and magnetic resonance images (MRI). The research has involved the investigation of statistical models and iterative reconstruction algorithms that accurately account for the physical characteristics of the SPECT acquisition system. It is our belief that SPECT quantification can be improved by accurately modeling the physical processes such as attenuation, scatter, geometric collimator response, and other factors that affect the measured projection data.

  11. Anti-CD22 90Y-epratuzumab tetraxetan combined with anti-CD20 veltuzumab: a phase I study in patients with relapsed/refractory, aggressive non-Hodgkin lymphoma.

    PubMed

    Witzig, Thomas E; Tomblyn, Michael B; Misleh, Jamal G; Kio, Ebenezer A; Sharkey, Robert M; Wegener, William A; Goldenberg, David M

    2014-11-01

    A lingering criticism of radioimmunotherapy in non-Hodgkin lymphoma is the use of cold anti-CD20 antibody along with the radiolabeled anti-CD20 antibody. We instead combined radioimmunotherapy with immunotherapy targeting different B-cell antigens. We evaluated the anti-CD22 (90)Y-epratuzumab tetraxetan with the anti-CD20 veltuzumab in patients with aggressive lymphoma in whom at least one prior standard treatment had failed, but who had not undergone stem cell transplantation. Eighteen patients (median age 73 years, median of 3 prior treatments) received 200 mg/m(2) veltuzumab once-weekly for 4 weeks, with (90)Y-epratuzumab tetraxetan at planned doses in weeks 3 and 4, and (111)In-epratuzumab tetraxetan in week 2 for imaging and dosimetry. Veltuzumab effectively lowered levels of B cells in the blood prior to the radioimmunotherapy doses. No significant immunogenicity or change in pharmacokinetics of either agent occurred in combination. (111)In imaging showed tumor targeting with acceptable radiation dosimetry to normal organs. For (90)Y-epratuzumab tetraxetan, transient myelosuppression was dose-limiting with 6 mCi/m(2) (222 MBq/m(2)) × 2 being the maximal tolerated dose. Of 17 assessable patients, nine (53%) had objective responses according to the 2007 revised treatment response criteria, including three (18%) complete responses (2 relapsing after 11 and 13 months, 1 continuing to be clinically disease-free at 19 months), and six (35%) partial responses (1 relapsing after 14 months, 5 at 3 - 7 months). Responses occurred in patients with different lymphoma histologies, treated at different (90)Y dose levels, and with a predicted risk of poor outcome, most importantly including five of the six patients treated with the maximal tolerated dose (2 of whom achieved durable complete responses). In conclusion, the combination of (90)Y-epratuzumab tetraxetan and veltuzumab was well-tolerated with encouraging therapeutic activity in this difficult-to-treat population

  12. Small-animal SPECT and SPECT/CT: important tools for preclinical investigation.

    PubMed

    Franc, Benjamin L; Acton, Paul D; Mari, Carina; Hasegawa, Bruce H

    2008-10-01

    The need to study dynamic biologic processes in intact small-animal models of disease has stimulated the development of high-resolution nuclear imaging methods. These methods are capable of clarifying molecular interactions important in the onset and progression of disease, assessing the biologic relevance of drug candidates and potential imaging agents, and monitoring therapeutic effectiveness of pharmaceuticals serially within a single-model system. Single-photon-emitting radionuclides have many advantages in these applications, and SPECT can provide 3-dimensional spatial distributions of gamma- (and x-) ray-emitting radionuclide imaging agents or therapeutics. Furthermore, combining SPECT with CT in a SPECT/CT system can assist in defining the anatomic context of biochemical processes and improve the quantitative accuracy of the SPECT data. Over the past decade, dedicated small-animal SPECT and SPECT/CT systems have been developed in academia and industry. Although significant progress in this arena has been realized through system development and biologic application, further innovation continues to address challenges in camera sensitivity, spatial resolution, and image reconstruction and quantification. The innumerable applications of small-animal SPECT and SPECT/CT in drug development, cardiology, neurology, and oncology are stimulating further investment in education, research, and development of these dedicated small-animal imaging modalities. PMID:18794275

  13. Studies of polarization bremsstrahlung and ordinary bremsstrahlung from 89Sr beta particles in metallic targets in the photon energy region of 1-100 keV

    NASA Astrophysics Data System (ADS)

    Singh, Amrit; Dhaliwal, A. S.

    2015-06-01

    Studies of polarization bremsstrahlung (PB) and ordinary bremsstrahlung (OB) produced by the 89Sr beta emitter in Al, Ti, Sn and Pb targets were undertaken at photon energies of 1-100 keV. The experimental results are compared with the Elwert corrected (non-relativistic) Bethe-Heitler (EBH) theory and the modified Elwert factor (relativistic) Bethe-Heitler (Fmod BH) theory for OB and with the Avdonina and Pratt (Fmod BH + PB) theory for total bremsstrahlung (BS). These results are in agreement with the Fmod BH + PB theory up to 13 keV, 16 keV, 22 keV and 28 keV energies for Al, Ti, Sn and Pb targets, respectively; Fmod BH theory is more accurate at higher energies.

  14. Effects of internal bremsstrahlung of tritium β-decay and surface roughness in the BIXS method

    NASA Astrophysics Data System (ADS)

    Mao, L.; An, Z.; Liang, J. H.; Long, X. G.; Peng, S. M.; Zhang, W. G.

    2011-01-01

    We have studied the effects of the internal bremsstrahlung of tritium β-decay, sample surface roughness and tritium content as well on the tritium β-decay induced X-ray spectroscopy (BIXS) for tritium measurements based on Monte Carlo simulations. The Knipp-Uhlenbeck-Bloch theoretical model was adopted for the internal bremsstrahlung. It is found that the contributions of internal bremsstrahlung of tritium β-decays are approximately 30%, 10%, 4% and 2% of the corresponding external bremsstrahlung for C, Ti, Mo and W materials, respectively, and the sample surface roughness may cause an error of several percent in the BIXS method if the surface roughness of a sample is in a reasonable range. Moreover, the effect of tritium content should be taken into account when a sample contains a large amount of tritium, otherwise, the tritium contents measured by the BIXS method will be underestimated, for example, by up to ˜15% for Ti metal.

  15. Applicability study on existing dosimetry systems to high-power Bremsstrahlung irradiation

    NASA Astrophysics Data System (ADS)

    Mehta, Kishor; Kojima, Takuji; Sunaga, Hiromi

    2003-12-01

    Applicability of the existing dosimetry systems to high-power Bremsstrahlung irradiation was investigated through a dose intercomparison study, where several dosimeters were irradiated in the dose range 4-12 kGy in identical polyethylene phantoms in a Bremsstrahlung beam obtained from a 5-MeV electron accelerator. Included in the study were alanine dosimeters molded by three different binders, three types of liquid dosimeters—ceric-cerous, dichromate and ethanol-chlorobenzen (ECB), and glutamine powder. The dosimeter responses for Bremsstrahlung radiation were analyzed at the issuing laboratories, and the dose values determined using calibration based on cobalt-60 gamma-ray irradiation. Dose values for all the three dose levels for all dosimetry systems were in good agreement—better than 3%. The results of the study demonstrate that these existing dosimetry systems have a potential for application to high-power Bremsstrahlung irradiation.

  16. EXPERIMENTAL SET UP TO MEASURE COHERENT BREMSSTRAHLUNG AND BEAM PROFILES IN RHIC.

    SciTech Connect

    TRBOJEVIC,D.; GASNER,D.; MACKAY,W.; MCINTYRE,G.; PEGGS,S.; TEPIKIAN,S.; SERBO,V.; KOTKIN,G.

    2002-06-03

    A proposal for an experiment to detect and measure with an array infrared detector either the infrared radiation from the beam-beam coherent bremsstrahlung or from the synchrotron light from the edge effect of large DX RHIC magnet is described. Predictions for the 100 GeV/nucleon gold and 250 GeV proton signals from both bremsstrahlung and synchtrotron radiation magnet edge effect are shown.

  17. Screening Effects on Nonrelativistic Bremsstrahlung in the Scattering of Electrons by Neutral Atoms

    NASA Technical Reports Server (NTRS)

    Jung, Young-Dae; Lee, Kun-Sang

    1995-01-01

    Atomic screening effects on nonrelativistic electron-atom bremsstrahlung radiation are investigated using a simple analytic solution of the Thomas-Fermi model for many-electron atoms. The Born approximation is assumed for the initial and final states of the projectile electron. The results show that the screening effect is important in the soft radiation region and is decreasing with increasing radiation. These results help provide correct information about the behavior of bound electrons in the target atom in bremsstrahlung processes.

  18. Optimizing the beam-beam alignment in an electron lens using bremsstrahlung

    SciTech Connect

    Montag, C.; Fischer, W.; Gassner, D.; Thieberger, P.; Haug, E.

    2010-05-23

    Installation of electron lenses for the purpose of head-on beam-beam compensation is foreseen at RHIC. To optimize the relative alignment of the electron lens beam with the circulating proton (or ion) beam, photon detectors will be installed to measure the bremsstrahlung generated by momentum transfer from protons to electrons. We present the detector layout and simulations of the bremsstrahlung signal as function of beam offset and crossing angle.

  19. Influence of cations on the complexation yield of DOTATATE with yttrium and lutetium: a perspective study for enhancing the 90Y and 177Lu labeling conditions.

    PubMed

    Asti, Mattia; Tegoni, Matteo; Farioli, Daniela; Iori, Michele; Guidotti, Claudio; Cutler, Cathy S; Mayer, Pat; Versari, Annibale; Salvo, Diana

    2012-05-01

    The DOTA macrocyclic ligand can form stable complexes with many cations besides yttrium and lutetium. For this reason, the presence of competing cationic metals in yttrium-90 and lutetium-177 chloride solutions can dramatically influence the radiolabeling yield. The aim of this study was to evaluate the coordination yield of yttrium- and lutetium-DOTATATE complexes when the reaction is performed in the presence of varying amounts of competing cationic impurities. In the first set of experiments, the preparation of the samples was performed by using natural yttrium and lutetium (20.4 nmol). The molar ratio between DOTATATE and these metals was 1 to 1. Metal competitors (Pb(2+), Zn(2+), Cu(2+), Fe(3+), Al(3+), Ni(2+), Co(2+), Cr(3+)) were added separately to obtain samples with varying molar ratio with respect to yttrium or lutetium (0.1, 0.5, 1, 2 and 10). The final solutions were analyzed through ultra high-performance liquid chromatography with an UV detector. In the second set of experiments, an amount of (90)Y or (177)Lu chloride (6 MBq corresponding to 3.3 and 45 pmol, respectively) was added to the samples, and a radio-thin layer chromatography analysis was carried out. The coordination of Y(3+) and Lu(3+) was dramatically influenced by low levels of Zn(2+), Cu(2+) and Co(2+). Pb(2+) and Ni(2+) were also shown to be strong competitors at higher concentrations. Fe(3+) was expected to be a strong competitor, but the effect on the incorporation was only partly dependent on its concentration. Al(3+) and Cr(3+) did not compete with Y(3+) and Lu(3+) in the formation of DOTATATE complexes. PMID:22172388

  20. Pediatric solid tumors: Evaluation by gallium-67 SPECT studies

    SciTech Connect

    Rossleigh, M.A.; Murray, I.P.; Mackey, D.W.; Bargwanna, K.A.; Nayanar, V.V. )

    1990-02-01

    A retrospective review of 37 children with a variety of solid tumors who underwent 60 {sup 67}Ga single-photon emission computed tomographic (SPECT) studies was performed. These studies were correlated with clinical and radiological findings and, where possible, histopathologic confirmation. In all studies, SPECT gave better definition and better anatomic localization of disease sites than obtained with planar views. SPECT detected more lesions in the head and neck (planar 16, SPECT 19), chest (planar 39, SPECT 45), and abdomen (planar 22, SPECT 24). In six of 20 patients scanned following chemotherapy, SPECT was useful in demonstrating that tracer accumulation in a normally located and shaped thymus indicated uptake resulting from thymic regeneration rather than tumor recurrence. It is concluded that {sup 67}Ga SPECT studies are very useful in the pediatric population, where perhaps because of their small size, interpretation of standard planar views may be difficult.

  1. A guide to SPECT equipment for brain imaging

    SciTech Connect

    Hoffer, P.B.; Zubal, G.

    1991-12-31

    Single photon emission computed tomography (SPECT) was started by Kuhl and Edwards about 30 years ago. Their original instrument consisted of four focused Nal probes mounted on a moving gantry. During the 1980s, clinical SPECT imaging was most frequently performed using single-headed Anger-type cameras which were modified for rotational as well as static imaging. Such instruments are still available and may be useful in settings where there are few patients and SPECT is used only occasionally. More frequently, however, dedicated SPECT devices are purchased which optimize equipment potential while being user-friendly. Modern SPECT instrumentation incorporates improvements in the detector, computers, mathematical formulations, electronics and display systems. A comprehensive discussion of all aspects of SPECT is beyond the scope of this article. The authors, however, discuss general concepts of SPECT, the current state-of-the-art in clinical SPECT instrumentation, and areas of common misunderstanding. 9 refs.

  2. Calibration of bremsstrahlung prefogged Kodak RAR 2492 film

    SciTech Connect

    Gorzen, D.F.; Armentrout, C.; Burek, A.; Bird, R.; Geddes, J.; Gerber, G. ); Rockett, P.D. )

    1990-10-01

    High-energy background radiation from PBFA II at Sandia National Laboratory introduces uncertainty regarding the effect of background fogging on the sensitivity of the x-ray film at soft x-ray energies. We have performed a calibration to determine how the sensitivity of the Kodak RAR 2492 film is affected by high-energy background radiation. To simulate the background radiation the film was fogged to various densities using a 10 keV bremsstrahlung spectrum. The film was then exposed to soft x-ray emission lines of Al {ital K}{alpha} and Ti {ital K}{alpha} selected by Bragg reflection from an electron bombardment source. The intensity of the x-ray flux was continuously monitored with a Si(Li) detector to eliminate error due to drift of the x-ray source's intensity. A microdensitometer with matched objectives was used to find the specular density of the exposed film. The results of the calibration are presented in the form of {ital D} vs log {ital l} for the various densities of the bremmstrahlung prefog exposures.

  3. Polarization of thermal bremsstrahlung emission due to electron pressure anisotropy

    NASA Astrophysics Data System (ADS)

    Komarov, S. V.; Khabibullin, I. I.; Churazov, E. M.; Schekochihin, A. A.

    2016-09-01

    Astrophysical plasmas are typically magnetized, with the Larmor radii of the charged particles many orders of magnitude smaller than their collisional mean free paths. The fundamental properties of such plasmas, e.g. conduction and viscosity, may depend on the instabilities driven by the anisotropy of the particle distribution functions and operating at scales comparable to the Larmor scales. We discuss a possibility that the pressure anisotropy of thermal electrons could produce polarization of thermal bremsstrahlung emission. In particular, we consider coherent large-scale motions in galaxy clusters to estimate the level of anisotropy driven by stretching of the magnetic-field lines by plasma flow and by heat fluxes associated with thermal gradients. Our estimate of the degree of polarization is ˜0.1 per cent at energies ≳kT. While this value is too low for the forthcoming generation of X-ray polarimeters, it is potentially an important proxy for the processes taking place at extremely small scales, which are impossible to resolve spatially. The absence of the effect at the predicted level may set a lower limit on the electron collisionality in the ICM. At the same time, the small value of the effect implies that it does not preclude the use of clusters as (unpolarized) calibration sources for X-ray polarimeters at this level of accuracy.

  4. SPECT imaging in a case of primary respiratory tract amyloidosis.

    PubMed

    Nishihara, M; Oda, J; Kamura, T; Kimura, M; Odano, I; Sakai, K

    1993-08-01

    SPECT findings in a very rare case of primary amyloidosis localized in the laryngotracheobronchial area are reported. SPECT using Tc-99m PYP revealed widespread uptake in the larynx and the entire tracheobronchial tree up to the subsegmental divisions; the areas corresponded to diffuse thickening and calcification of the walls on CT. SPECT using Ga-67 citrate also showed marked uptake in the same area, consistent with the findings shown by SPECT using Tc-99m PYP. PMID:8403700

  5. Influence of the electron-exchange and quantum shielding on the bremsstrahlung spectrum in degenerate quantum plasmas

    SciTech Connect

    Jung, Young-Dae

    2013-10-15

    The influence of the electron-exchange and quantum shielding on the bremsstrahlung spectrum is investigated in degenerate quantum plasmas. The impact-parameter analysis with the Shukla-Eliasson potential is applied to obtain the electron-ion bremsstrahlung radiation cross section as a function of the impact parameter, photon energy, projectile energy, electron-exchange parameter, Fermi energy, and plasmon energy. The result shows that the electron-exchange effect strongly enhances the bremsstrahlung radiation spectrum in degenerate quantum plasmas. It is also shown that the influence of the electron-exchange broadens the photon emission range in the electron-ion bremsstrahlung process. It is found that the electron-exchange effect focuses the bremsstrahlung photon energy in the soft photon domain. In addition, it is found that the bremsstrahlung radiation cross section increases with an increase of the Fermi energy and, however, decreases with increasing plasmon energy.

  6. Investigation of a {sup 90}Sr/{sup 90}Y source for intra-ocular treatment of wet age-related macular degeneration

    SciTech Connect

    Holmes, Shannon M.; Micka, John A.; DeWerd, Larry A.

    2009-10-15

    Purpose: The purpose of this study is to perform an extensive investigation of an approximately 2.5 mm long {sup 90}Sr/{sup 90}Y source designed for treating wet age-related macular degeneration. Methods: As part of this investigation, a NIST-traceable absorbed dose to water calibration technique was established, and a source deployment verification test was developed. The influence of treatment cannula construction tolerance on the measurements as well as the dose delivered to the patient was investigated using the Monte Carlo code MCNP5. Variation between production cannulae was quantified experimentally using a well-type ionization chamber, and additional measurements along with Monte Carlo calculations of the collimating insert used for source deployment verification were performed to validate the model. Results: Maximum variation in the integrated target dose was seen when the source was shifted laterally within the treatment cannula. For the well chamber measurements, the observed standard deviation in ionization current for a single source placed in different reference cannulae was {+-}0.3%, with a maximum observed range of less than {+-}0.5%. Clinical cannulae in the collimating insert showed an average of 17.8%{+-}0.4% of the reference signal when sources were fully deployed compared to 18.5% predicted by Monte Carlo calculations. This discrepancy has been attributed primarily to construction of the collimator since the collimation gap was observed to be approximately 0.025-0.075 mm smaller than specified. Construction tolerance of the well chamber insert as well as position tolerance of the cannula tip were both investigated, and their influence on the predicted signal was quantified. Additional measurements along with Monte Carlo based calculations of the collimating insert with polyethylene spacers added to the setup were performed to validate the Monte Carlo model. The shimmed Monte Carlo and measured data agree to within 1%, which is a magnitude

  7. Multicenter evaluation of the safety and efficacy of radioembolization in patients with unresectable colorectal liver metastases selected as candidates for 90Y resin microspheres

    PubMed Central

    Ball, David; Cohen, Steven J.; Cohn, Michael; Coldwell, Douglas M.; Drooz, Alain; Ehrenwald, Eduardo; Kanani, Samir; Rose, Steven C.; Nutting, Charles W.; Moeslein, Fred M.; Savin, Michael A.; Schirm, Sabine; Putnam, Samuel G.; Sharma, Navesh K.; Wang, Eric A.

    2015-01-01

    Background Metastatic colorectal cancer liver metastases Outcomes after RadioEmbolization (MORE) was an investigator-initiated case-control study to assess the experience of 11 US centers who treated liver-dominant metastases from colorectal cancer (mCRC) using radioembolization [selective internal radiation therapy (SIRT)] with yttrium-90-(90Y)-labeled resin microspheres. Methods Data from 606 consecutive patients who received radioembolization between July 2002 and December 2011 were collected by an independent research organization. Adverse events (AEs) and survival were compared across lines of treatment using Fisher’s exact test and Kaplan-Meier estimates, respectively. Results Patients received a median of 2 (range, 0-6) lines of prior chemotherapy; 35.1% had limited extrahepatic metastases. Median tumor-to-liver ratio and -activity administered at first procedure were 15% and 1.17 GBq, respectively. Hospital stay was <24 hours in 97.8% cases. Common grade ≥3 AEs over 184 days follow-up were: abdominal pain (6.1%), fatigue (5.5%), hyperbilirubinemia (5.4%), ascites (3.6%) and gastrointestinal ulceration (1.7%). There was no statistical difference in AEs across treatment lines (P>0.05). Median survivals [95% confidence interval (CI)] following radioembolization as a 2nd-line, 3rd-line, or 4th-plus line were 13.0 (range, 10.5-14.6), 9.0 (range, 7.8-11.0), and 8.1 (range, 6.4-9.3) months, respectively; and significantly prolonged in patients with ECOG 0 vs. ≥1 (P=0.009). Statistically significant independent variables for survival at radioembolization were: disease stage [extrahepatic metastases, extent of liver involvement (tumor-to-treated-liver ratio)], liver function (uncontrolled ascites, albumin, alkaline phosphatase, aspartate transaminase), leukocytes, and prior chemotherapy. Conclusions Radioembolization appears to have a favorable risk/benefit profile, even among mCRC patients who had received ≥3 prior lines of chemotherapy. PMID:25830033

  8. Rodent brain imaging with SPECT/CT

    SciTech Connect

    Seo, Youngho; Gao, D.-W.; Hasegawa, Bruce H.; Dae, Michael W.; Franc, Benjamin L.

    2007-04-15

    We evaluated methods of imaging rat models of stroke in vivo using a single photon emission computed tomography (SPECT) system dedicated to small animal imaging (X-SPECT{sup TM}, Gamma Medica-Ideas, Northridge, CA). An animal model of ischemic stroke was developed for in vivo SPECT/CT imaging using the middle cerebral artery occlusion (MCAO) technique. The presence of cerebral ischemia was verified in ex vivo studies using triphenyltetrazolium chloride (TTC) staining. In vivo radionuclide imaging of cerebral blood flow was performed in rats following MCAO using dynamic planar imaging of {sup 99m}Tc-exametazime with parallel hole collimation. This was followed immediately by in vivo radionuclide imaging of cerebral blood flow with {sup 99m}Tc-exametazime in the same animals using 1-mm pinhole SPECT. Correlated computed tomography imaging was performed to localize radiopharmaceutical uptake. The animals were allowed to recover and ex vivo autoradiography was performed with separate administration of {sup 99m}Tc-exametazime. Time activity curve of {sup 99m}Tc-exametazime showed that the radiopharmaceutical uptake could be maintained for over 9 min. The activity would be expected to be relatively stable for a much longer period, although the data were only obtained for 9 min. TTC staining revealed sizable infarcts by visual observation of inexistence of TTC stain in infracted tissues of MCAO rat brains. In vivo SPECT imaging showed cerebral blood flow deficit in the MCAO model, and the in vivo imaging result was confirmed with ex vivo autoradiography. We have demonstrated a capability of imaging regions of cerebral blood flow deficit in MCAO rat brains in vivo using a pinhole SPECT dedicated to small animal imaging.

  9. Tumour control probability derived from dose distribution in homogeneous and heterogeneous models: assuming similar pharmacokinetics, 125Sn-177Lu is superior to 90Y-177Lu in peptide receptor radiotherapy

    NASA Astrophysics Data System (ADS)

    Walrand, Stephan; Hanin, François-Xavier; Pauwels, Stanislas; Jamar, François

    2012-07-01

    Clinical trials on 177Lu-90Y therapy used empirical activity ratios. Radionuclides (RN) with larger beta maximal range could favourably replace 90Y. Our aim is to provide RN dose-deposition kernels and to compare the tumour control probability (TCP) of RN combinations. Dose kernels were derived by integration of the mono-energetic beta-ray dose distributions (computed using Monte Carlo) weighted by their respective beta spectrum. Nine homogeneous spherical tumours (1-25 mm in diameter) and four spherical tumours including a lattice of cold, but alive, spheres (1, 3, 5, 7 mm in diameter) were modelled. The TCP for 93Y, 90Y and 125Sn in combination with 177Lu in variable proportions (that kept constant the renal cortex biological effective dose) were derived by 3D dose kernel convolution. For a mean tumour-absorbed dose of 180 Gy, 2 mm homogeneous tumours and tumours including 3 mm diameter cold alive spheres were both well controlled (TCP > 0.9) using a 75-25% combination of 177Lu and 90Y activity. However, 125Sn-177Lu achieved a significantly better result by controlling 1 mm-homogeneous tumour simultaneously with tumours including 5 mm diameter cold alive spheres. Clinical trials using RN combinations should use RN proportions tuned to the patient dosimetry. 125Sn production and its coupling to somatostatin analogue appear feasible. Assuming similar pharmacokinetics 125Sn is the best RN for combination with 177Lu in peptide receptor radiotherapy justifying pharmacokinetics studies in rodent of 125Sn-labelled somatostatin analogues.

  10. Gas bremsstrahlung studies for medium energy electron storage rings using FLUKA Monte Carlo code

    NASA Astrophysics Data System (ADS)

    Sahani, Prasanta Kumar; Haridas, G.; Sinha, Anil K.; Hannurkar, P. R.

    2016-02-01

    Gas bremsstrahlung is generated due to the interaction of the stored electron beam with residual gas molecules of the vacuum chamber in a storage ring. As the opening angle of the bremsstrahlung is very small, the scoring area used in Monte Carlo simulation plays a dominant role in evaluating the absorbed dose. In the present work gas bremsstrahlung angular distribution and absorbed dose for the energies ranging from 1 to 5 GeV electron storage rings are studied using the Monte Carlo code, FLUKA. From the study, an empirical formula for gas bremsstrahlung dose estimation was deduced. The results were compared with the data obtained from reported experimental values. The results obtained from simulations are found to be in very good agreement with the reported experimental data. The results obtained are applied in estimating the gas bremsstrahlung dose for 2.5 GeV synchrotron radiation source, Indus-2 at Raja Ramanna Centre for Advanced Technology, India. The paper discusses the details of the simulation and the results obtained.

  11. Z-dependence of thick-target bremsstrahlung produced by monoenergetic low-energy electrons

    NASA Astrophysics Data System (ADS)

    Czarnecki, S.; Short, A.; Williams, S.

    2016-07-01

    The dependence of thick-target bremsstrahlung emitted by low-energy beams of monoenergetic electrons on the atomic number of the target material has been investigated experimentally for incident electron energies of 4.25 keV and 5.00 keV using thick aluminum, copper, silver, tungsten, and gold targets. Experimental data suggest that the intensity of the thick-target bremsstrahlung emitted is more strongly dependent on the atomic number of the target material for photons with energies that are approximately equal to the energy of the incident electrons than at lower energies, and also that the dependence of thick-target bremsstrahlung on the atomic number of the target material is stronger for incident electrons of higher energies than for incident electrons of lower energies. The results of the experiments are compared to the results of simulations performed using the PENELOPE program (which is commonly used in medical physics) and to thin-target bremsstrahlung theory, as well. Comparisons suggest that the experimental dependence of thick-target bremsstrahlung on the atomic number of the target material may be slightly stronger than the results of the PENELOPE code suggest.

  12. Anti-CD22 90Y-epratuzumab tetraxetan combined with anti-CD20 veltuzumab: a phase I study in patients with relapsed/refractory, aggressive non-Hodgkin lymphoma

    PubMed Central

    Witzig, Thomas E.; Tomblyn, Michael B.; Misleh, Jamal G.; Kio, Ebenezer A.; Sharkey, Robert M.; Wegener, William A.; Goldenberg, David M.

    2014-01-01

    A lingering criticism of radioimmunotherapy in non-Hodgkin lymphoma is the use of cold anti-CD20 antibody along with the radiolabeled anti-CD20 antibody. We instead combined radioimmunotherapy with immunotherapy targeting different B-cell antigens. We evaluated the anti-CD22 90Y-epratuzumab tetraxetan with the anti-CD20 veltuzumab in patients with aggressive lymphoma in whom at least one prior standard treatment had failed, but who had not undergone stem cell transplantation. Eighteen patients (median age 73 years, median of 3 prior treatments) received 200 mg/m2 veltuzumab once-weekly for 4 weeks, with 90Y-epratuzumab tetraxetan at planned doses in weeks 3 and 4, and 111In-epratuzumab tetraxetan in week 2 for imaging and dosimetry. Veltuzumab effectively lowered levels of B cells in the blood prior to the radioimmunotherapy doses. No significant immunogenicity or change in pharmacokinetics of either agent occurred in combination. 111In imaging showed tumor targeting with acceptable radiation dosimetry to normal organs. For 90Y-epratuzumab tetraxetan, transient myelosuppression was dose-limiting with 6 mCi/m2 (222 MBq/m2) × 2 being the maximal tolerated dose. Of 17 assessable patients, nine (53%) had objective responses according to the 2007 revised treatment response criteria, including three (18%) complete responses (2 relapsing after 11 and 13 months, 1 continuing to be clinically disease-free at 19 months), and six (35%) partial responses (1 relapsing after 14 months, 5 at 3 – 7 months). Responses occurred in patients with different lymphoma histologies, treated at different 90Y dose levels, and with a predicted risk of poor outcome, most importantly including five of the six patients treated with the maximal tolerated dose (2 of whom achieved durable complete responses). In conclusion, the combination of 90Y-epratuzumab tetraxetan and veltuzumab was well-tolerated with encouraging therapeutic activity in this difficult-to-treat population. PMID:25150258

  13. Performance evaluation of D-SPECT: a novel SPECT system for nuclear cardiology

    NASA Astrophysics Data System (ADS)

    Erlandsson, Kjell; Kacperski, Krzysztof; van Gramberg, Dean; Hutton, Brian F.

    2009-05-01

    D-SPECT (Spectrum Dynamics, Israel) is a novel SPECT system for cardiac perfusion studies. Based on CZT detectors, region-centric scanning, high-sensitivity collimators and resolution recovery, it offers potential advantages over conventional systems. A series of measurements were made on a β-version D-SPECT system in order to evaluate its performance in terms of energy resolution, scatter fraction, sensitivity, count rate capability and resolution. Corresponding measurements were also done on a conventional SPECT system (CS) for comparison. The energy resolution of the D-SPECT system at 140 keV was 5.5% (CS: 9.25%), the scatter fraction 30% (CS: 34%), the planar sensitivity 398 s-1 MBq-1 per head (99mTc, 10 cm) (CS: 72 s-1 MBq-1), and the tomographic sensitivity in the heart region was in the range 647-1107 s-1 MBq-1 (CS: 141 s-1 MBq-1). The count rate increased linearly with increasing activity up to 1.44 M s-1. The intrinsic resolution was equal to the pixel size, 2.46 mm (CS: 3.8 mm). The average reconstructed resolution using the standard clinical filter was 12.5 mm (CS: 13.7 mm). The D-SPECT has superior sensitivity to that of a conventional system with similar spatial resolution. It also has excellent energy resolution and count rate characteristics, which should prove useful in dynamic and dual radionuclide studies.

  14. Anomalous inverse bremsstrahlung heating of laser-driven plasmas

    NASA Astrophysics Data System (ADS)

    Kundu, Mrityunjay

    2016-05-01

    Absorption of laser light in plasma via electron-ion collision (inverse bremsstrahlung) is known to decrease with the laser intensity as I 0 -3/2 or with the electron temperature as T e -3/2 where Coulomb logarithm ln Λ = 0.5ln(1 + k 2 min/k 2 max) in the expression of electron-ion collision frequency v ei is assumed to be independent of ponderomotive velocity v 0 = E0/ω which is unjustified. Here k -1 min = v th/max(ω, ω p), and k -1 max = Z/v 2 th are maximum and minimum cut-off distances of the colliding electron from the ion, v th = √T e is its thermal velocity, ω, ω p are laser and plasma frequency. Earlier with a total velocity v = (v 2 0 + v 2 th)1/2 dependent ln Λ(v) it was reported that v ei and corresponding fractional laser absorption (α) initially increases with increasing intensity, reaches a maximum value, and then fall according to the conventional I 0 -3/2 scaling. This anomalous increase in v ei and α may be objected due to an artifact introduced in ln Λ(v) through k-1 min ∝ v. Here we show similar anomalous increase of v ei and α versus I 0 (in the low temperature and under-dense density regime) with quantum and classical kinetic models of v ei without using ln Λ, but a proper choice of the total velocity dependent inverse cut-off length kmax -1 ∝ v 2 (in classical case) or kmax ∝ v (in quantum case). For a given I 0 < 5 × 1014Wcm-2, v ei versus T e also exhibits so far unnoticed identical anomalous increase as v ei versus Io, even if the conventional k max ∝ v2 th, or k max ∝ v th is chosen. However, for higher T e > 15 eV, anomalous growth of vei and a disappear. The total velocity dependent k max in kinetic models, as proposed here, may explain anomalous increase of a with I 0 measured in some earlier laser-plasma experiments. This work may be important to understand collisional absorption in the under-dense pre-plasma region due to low intensity pre-pulses and amplified spontaneous emission (ASE) pedestal in the

  15. Vector bremsstrahlung by ultrarelativistic collisions in higher dimensions

    NASA Astrophysics Data System (ADS)

    Constantinou, Yiannis; Spirin, Pavel

    2014-01-01

    A classical computation of vector bremsstrahlung in ultrarelativistic gravitational-force collisions of massive point particles is presented in an arbitrary number d of extra dimensions. Our method adapts the post-linear formalism of General Relativity to the multidimensional case. The total emitted energy, as well as its angular and frequency distribution and characteristic values, are discussed in detail. For an electromagnetic mediation propagated in the bulk, the emitted energy E em of scattering with impact parameter b has magnitude E em ~ e 4 e '2γ d+2 /( m 2 b 3 d+3), with dominant frequency ω em ~ γ2 /b. For the gravitational force the charge emits via vector field, propagated in the bulk, energy E rad ~ [ G D m ' e]2γ d+2 /b 3 d+3 for d ≥ 2, with dominant frequency ω ~ γ2 /b; and energy E rad ~ [ G 5 m ' e 5]2 γ3 ln γ /b 6 for d = 1, with most of the energy coming from a wide frequency region ω ∈ [(γ /b) , (γ2 /b)]. For the UED model with extra space volume V = (2 πR) d the emitted energy is E UED ~ ( b d /V)2 E rad. Finally, for the ADD model, including four dimensions, the electromagnetic field living on 3-brane, loses on emission the energy E ADD ~ [ G D m ' e]2 γ3 /( V b 2 d+3), with characteristic frequency ω ADD ~ γ /b. The contribution of the low frequency part of the radiation (soft photons) to the total radiated energy is shown to be negligible for all values of d. The domain of validity of the classical result is discussed. The result is analyzed from the viewpoint of the de Witt-Brehme-Hobbs equation (and corresponding equations in higher dimensions). The different frequency domains and their competition mentioned above, may be explained as coming from different terms in this equation. Thus the whole emission process may be naturally split in two sub-processes with drastically different spectral and temporal characteristics.

  16. Freehand SPECT in low uptake situations

    NASA Astrophysics Data System (ADS)

    Lasser, Tobias; Ziegler, Sibylle I.; Navab, Nassir

    2011-03-01

    3D functional imaging in the operating room can be extremely useful for some procedures like SLN mapping or SLN biopsies. Freehand SPECT is an example of such an imaging modality, combining manually scanned, hand-held 1D gamma detectors with spatial positioning systems in order to reconstruct localized 3D SPECT images, for example in the breast or neck region. Standard series expansion methods are applied together with custom physical models of the acquisition process and custom filtering procedures to perform 3D tomographic reconstruction from sparse, limited-angle and irregularly sampled data. A Freehand SPECT system can easily be assembled on a mobile cart suitable for use in the operating room. This work addresses in particular the problem of objects with low uptake (like sentinel lymph nodes), where reconstruction tends to be difficult due to low signal to noise ratio. In a neck-like phantom study, we show that four simulated nodes of 250 microliter volume with 0.06% respectively 0.03% uptake of a virtual 70MBq injection of Tc99m (the typical activity for SLN procedures at our hospital) in a background of water can be reconstructed successfully using careful filtering procedures in the reconstruction pipeline. Ten independent Freehand SPECT scans of the phantom were performed by several different operators, with an average scan duration of 5.1 minutes. The resulting reconstructions show an average spatial accuracy within voxel dimensions (2.5mm) compared to CT and exhibit correct relative quantification.

  17. Body Deformation Correction for SPECT Imaging

    PubMed Central

    Gu, Songxiang; McNamara, Joseph E.; Mitra, Joyeeta; Gifford, Howard C.; Johnson, Karen; Gennert, Michael A.; King, Michael A.

    2010-01-01

    Patient motion degrades the quality of SPECT studies. Body bend and twist are types of patient deformation, which may occur during SPECT imaging, and which has been generally ignored in SPECT motion correction strategies. To correct for these types of motion, we propose a deformation model and its inclusion within an iterative reconstruction algorithm. Two experiments were conducted to investigate the applicability of our model. In the first experiment, the return of the postmotion-compensation locations of markers on the body-surface of a volunteer to approximate their original coordinates is used to examine our method of estimating the parameters of our model and the parameters’ use in undoing deformation. The second experiment employed simulated projections of the MCAT phantom formed using an analytical projector which includes attenuation and distance-dependent resolution to investigate applications of our model in reconstruction. We demonstrate in the simulation studies that twist and bend can significantly degrade SPECT image quality visually. Our correction strategy is shown to be able to greatly diminish the degradation seen in the slices, provided the parameters are estimated accurately. We view this work as a first step towards being able to estimate and correct patient deformation based on information obtained from marker tracking data. PMID:20336188

  18. LPM Interference and Cherenkov-like Gluon Bremsstrahlung in DenseMatter

    SciTech Connect

    Majumder, Abhijit; Wang, Xin-Nian

    2005-07-26

    Gluon bremsstrahlung induced by multiple parton scattering in a finite dense medium has a unique angular distribution with respect to the initial parton direction. A dead-cone structure with an opening angle; theta2{sub 0}; approx 2(1-z)/(zLE) for gluons with fractional energy z arises from the Landau-Pomeran chuck-Migdal (LPM) interference. In a medium where the gluon's dielectric constant is; epsilon>1, the LPM interference pattern is shown to become Cherenkov-like with an increased opening angle determined by the dielectric constant$/cos2/theta{sub c}=z+(1-z)//epsilon$. For a large dielectric constant/epsilon; gg 1+2/z2LE, the corresponding total radiative parton energy loss is about twice that from normal gluon bremsstrahlung. Implications of this Cherenkov-like gluon bremsstrahlung to the jet correlation pattern in high-energy heavy-ion collisions is discussed.

  19. Lectures from the workshop on nucleon-nucleon bremsstrahlung, January 25--26, 1990

    SciTech Connect

    Gibson, B.F.; Schillaci, M.E.; Wender, S.A.

    1990-07-01

    The Nucleon-Nucleon Bremsstrahlung Workshop was convened at LAMPF on 25--26 January 1990 in order to review the theoretical and experimental aspects of that reaction with focus on a possible new initiative to measure neutron-proton bremsstrahlung using the intermediate-energy, white-spectrum neutron source at the LAMPF/WNR facility. Over the course of this intense day-and-a-half workshop, experts in the field established the historical perspective for both theory and experiment, presented result of recent calculations, and examined new approaches to the difficult neutron-proton bremsstrahlung experiment. Theoretical and experimental working groups generated recommendations for action and actually converged upon a plan for an experimental program, not just a single measurement.

  20. Dose Measurements of Bremsstrahlung-Produced Neutrons at the Advanced Photon Source

    SciTech Connect

    Job, P.K.; Pisharody, M.; Semones, E.

    1998-08-01

    Bremsstrahlung is generated in the storage rings of the synchrotron radiation facilities by the radiative interaction of the circulating particle beam with both the residual gas molecules and storage ring components. These bremsstrahlung photons, having an energy range of zero to the maximum energy of the particle beam, interact with beamline components like beam stops and collimators generating photoneutrons of varying energies. There are three main processes by which photoneutrons may be produced by the high energy bremsstrahlung photons: giant nuclear dipole resonance and decay (10 MeV < E{sub {gamma}} < 30 MeV), quasi-deuteron production and decay (50 MeV < E{sub {gamma}} < 300 MeV), and intranuclear cascade and evaporation (E{sub {gamma}} > 140 MeV). The giant resonance neutrons are emitted almost isotropically and have an average energy of about 2 MeV. High energy neutrons (E > 10 MeV) emitted from the quasi-deuteron decay and intranuclear cascade are peaked in the forward direction. At the Advanced Photon Source (APS), where bremsstrahlung energy can be as high as 7 GeV, production of photoneutrons in varying yields is possible from all of the above three processes. The bremsstrahlung produced along a typical 15.38-m straight path of the insertion device (ID) beamline of the APS has been measured and analyzed in previous studies. High-Z materials constituting the beamline components, such as collimators and beam stops, can produce photoneutrons upon interaction with these bremsstrahlung photons. The 1/E nature of the bremsstrahlung spectrum and the fact that the photoneutron production cross section is comparatively larger in the energy region 10 MeV < E{sub {gamma}} < 30 MeV, results in the giant resonance interaction being the dominant mechanism that generates photoneutrons at the APS. Such neutron flux in the vicinities of the first optics enclosures (FOEs) of ID beamlines is important, from the point of view of radiation protection of the personnel. Only

  1. Monte Carlo scatter correction for SPECT

    NASA Astrophysics Data System (ADS)

    Liu, Zemei

    The goal of this dissertation is to present a quantitatively accurate and computationally fast scatter correction method that is robust and easily accessible for routine applications in SPECT imaging. A Monte Carlo based scatter estimation method is investigated and developed further. The Monte Carlo simulation program SIMIND (Simulating Medical Imaging Nuclear Detectors), was specifically developed to simulate clinical SPECT systems. The SIMIND scatter estimation (SSE) method was developed further using a multithreading technique to distribute the scatter estimation task across multiple threads running concurrently on multi-core CPU's to accelerate the scatter estimation process. An analytical collimator that ensures less noise was used during SSE. The research includes the addition to SIMIND of charge transport modeling in cadmium zinc telluride (CZT) detectors. Phenomena associated with radiation-induced charge transport including charge trapping, charge diffusion, charge sharing between neighboring detector pixels, as well as uncertainties in the detection process are addressed. Experimental measurements and simulation studies were designed for scintillation crystal based SPECT and CZT based SPECT systems to verify and evaluate the expanded SSE method. Jaszczak Deluxe and Anthropomorphic Torso Phantoms (Data Spectrum Corporation, Hillsborough, NC, USA) were used for experimental measurements and digital versions of the same phantoms employed during simulations to mimic experimental acquisitions. This study design enabled easy comparison of experimental and simulated data. The results have consistently shown that the SSE method performed similarly or better than the triple energy window (TEW) and effective scatter source estimation (ESSE) methods for experiments on all the clinical SPECT systems. The SSE method is proven to be a viable method for scatter estimation for routine clinical use.

  2. Evaluation of bremsstrahlung contribution to photon transport in coupled photon-electron problems

    NASA Astrophysics Data System (ADS)

    Fernández, Jorge E.; Scot, Viviana; Di Giulio, Eugenio; Salvat, Francesc

    2015-11-01

    The most accurate description of the radiation field in x-ray spectrometry requires the modeling of coupled photon-electron transport. Compton scattering and the photoelectric effect actually produce electrons as secondary particles which contribute to the photon field through conversion mechanisms like bremsstrahlung (which produces a continuous photon energy spectrum) and inner-shell impact ionization (ISII) (which gives characteristic lines). The solution of the coupled problem is time consuming because the electrons interact continuously and therefore, the number of electron collisions to be considered is always very high. This complex problem is frequently simplified by neglecting the contributions of the secondary electrons. Recent works (Fernández et al., 2013; Fernández et al., 2014) have shown the possibility to include a separately computed coupled photon-electron contribution like ISII in a photon calculation for improving such a crude approximation while preserving the speed of the pure photon transport model. By means of a similar approach and the Monte Carlo code PENELOPE (coupled photon-electron Monte Carlo), the bremsstrahlung contribution is characterized in this work. The angular distribution of the photons due to bremsstrahlung can be safely considered as isotropic, with the point of emission located at the same place of the photon collision. A new photon kernel describing the bremsstrahlung contribution is introduced: it can be included in photon transport codes (deterministic or Monte Carlo) with a minimal effort. A data library to describe the energy dependence of the bremsstrahlung emission has been generated for all elements Z=1-92 in the energy range 1-150 keV. The bremsstrahlung energy distribution for an arbitrary energy is obtained by interpolating in the database. A comparison between a PENELOPE direct simulation and the interpolated distribution using the data base shows an almost perfect agreement. The use of the data base increases

  3. Measurement of gas bremsstrahlung from the insertion device beamlines of the advanced photon source

    SciTech Connect

    Pisharody, M.; Job, P.K.; Magill, S.

    1997-03-01

    High energy electron storage rings generate energetic bremsstrahlung photons through radiative interaction of the electrons (or positrons) with the residual gas molecules inside the storage ring. The resulting radiation exits at an average emittance angle of (m{sub 0}c{sub 2}/E) radian with respect to the electron beam path, where m{sub 0}c{sup 2} is the rest mass of E the electron and E its kinetic energy. Thus, at straight sections of the storage rings, moving electrons will produce a narrow and intense monodirectional photon beam. At synchrotron radiation facilities, where beamlines are channeled out of the storage ring, a continuous gas bremsstrahlung spectrum, with a maximum energy of the electron beam, will be present. There are a number of compelling reasons that a measurement of the bremsstrahlung characteristics be conducted at the Advanced Photon Source (APS) storage ring. Although the number of residual gas molecules present in the storage ring at typical nTorr vacuum is low, because of the long straight paths of the electrons in the storage ring at APS, significant production of bremsstrahlung will be produced. This may pose a radiation hazard. It is then imperative that personnel be shielded from dose rates due to this radiation. There are not many measurements available for gas bremsstrahlung, especially for higher electron beam energies. The quantitative estimates of gas bremsstrahlung from storage rings as evaluated by Monte Carlo codes also have several uncertainties. They are in general calculated for air at atmospheric pressure, the results of which are then extrapolated to typical storage ring vacuum values (of the order of 10{sup -9} Torr). Realistically, the actual pressure profile can vary inside the narrow vacuum chamber. Also, the actual chemical composition of the residual gas inside the storage ring is generally different from that of air.

  4. Bremsstrahlung radiation from slow electrons in a Coulomb field: Classical limit and quantum correction

    SciTech Connect

    Manakov, N. L. Krylovetsky, A. A.; Marmo, S. I.

    2015-11-15

    Compact analytic expressions have been derived by a direct expansion in ħ → 0 for the nonrelativistic amplitude of Coulomb bremsstrahlung radiation (BR), the differential (in frequency and angles of the scattered electron) BR cross section, and the triply differential BR cross section that takes into account the bremsstrahlung photon direction and polarization and the scattered electron direction. They contain the classical limit and a quantum correction of the order of ħ at an arbitrary BR frequency ω. An explicit expression has been found for the quantum correction of the order of ħ to the classical BR spectrum.

  5. Thermal and Nonthermal Electron-ion Bremsstrahlung Spectrum from High-Temperature Plasmas

    NASA Technical Reports Server (NTRS)

    Jung, Young-Dae

    1994-01-01

    Electron-ion bremsstrahlung radiation from high-temperature plasmas is investigated. The first- and second-order Coulomb corrections in the nonrelativistic bremsstrahlung radiation power are obtained by the Elwert-Sommerfeld factor. In this paper, two cases of the electron distributions, the thermal and nonthermal power-law distributions, are considered. The inclusion of Coulomb corrections is necessary in deducing correctly the electron distribution function from radiation data. These results provide the correct information of electron distributions in high-temperature plasmas, such as in inertial confinement fusion plasmas and in the astrophysical hot thermal and nonthermal x-ray sources.

  6. External Bremsstrahlung of 147Pm in PbCl 2 and CdO

    NASA Astrophysics Data System (ADS)

    Manjunatha, H. C.; Suresh, K. C.; Rudraswamy, B.

    2010-07-01

    External Bremsstrahlung spectra produced in thick target compounds like lead chloride (PbCl 2) and cadmium oxide (CdO) by β particles of 147Pm (225 keV) were measured using 3.8 cm×3.8 cm NaI(Tl) crystal. The spectra were unfolded using Liden-Starfelt procedure. The unfolded spectra were compared with Tseng-Pratt theory. The measured spectra show fairly good agreement at low energy end of spectrum and some deviation (less than 10%) at higher energy end of spectrum with the theory. The estimation of Bremsstrahlung dose from the measured/theoretical spectrum is also discussed.

  7. Estimation of photoneutron yield from beryllium target irradiated by variable energy microtron-based bremsstrahlung radiation

    NASA Astrophysics Data System (ADS)

    Eshwarappa, K. M.; Ganesh; Siddappa, K.; Kashyap, Yogesh; Sinha, Amar; Sarkar, P. S.; Godwal, B. K.

    2005-03-01

    The possibility of setting up microtron-based photoneutron source by utilizing bremsstrahlung radiation interaction with beryllium targets is critically examined. The bremsstrahlung yield for tantalum (Ta) target is obtained by EGS4 simulation. The neutron yield is estimated theoretically by MCNP simulation. The yield was measured experimentally by neutron irradiation of calibrated SSNTD CR-39 films. The total neutron yield is found to be of the order 10 10 n/s for 250 Hz PRR and 10 9 n/s for 50 Hz PRR. A detailed comparison shows good agreement between theoretical and experimentally measured yields.

  8. Quantum diffraction and shielding effects on the low-energy electron-ion bremsstrahlung in two-component semiclassical plasmas

    SciTech Connect

    Lee, Myoung-Jae; Jung, Young-Dae

    2015-10-15

    The quantum diffraction and shielding effects on the low-energy bremsstrahlung process are investigated in two-component semiclassical plasmas. The impact-parameter analysis with the micropotential taking into account the quantum diffraction and shielding effects is employed to obtain the electron-ion bremsstrahlung radiation cross section as a function of the de Broglie wavelength, density parameter, impact parameter, photon energy, and projectile energy. The result shows that the influence of quantum diffraction and shielding strongly suppresses the bremsstrahlung radiation spectrum in semiclassical plasmas. It is found that the quantum diffraction and shielding effects have broaden the photon emission domain. It is also found that the photon emission domain is almost independent of the radiation photon energy. In addition, it is found that the influence of quantum diffraction and shielding on the bremsstrahlung spectrum decreases with an increase of the projectile energy. The density effect on the electron-ion bremsstrahlung cross section is also discussed.

  9. The role of SPECT/CT in skeletal malignancies.

    PubMed

    Ghosh, Partha

    2014-04-01

    Bone scintigraphy is widely used for the detection of skeletal metastases, particularly in prostate and breast cancer. Although planar imaging is widely used, single-photon emission computed tomography (SPECT) imaging has demonstrated higher sensitivity. SPECT/CT imaging with the integration of CT and SPECT gantries has enhanced bone scintigraphy by providing accurate lesion localization and characterization of equivocal and solitary bone lesions. The key impact has been enhanced diagnostic confidence in the differentiation of benign from malignant skeletal lesions made possible by accurate localization of lesions to facet joints, vertebral bodies, or pedicles due to the exact coregistration of CT and SPECT as well as consideration of sclerosis or lysis within the lesion seen on CT. Several studies comparing planar, SPECT, and SPECT/CT in equivocal lesions have demonstrated a substantial improvement in specificity with SPECT/CT. This review highlights the key studies demonstrating the value of SPECT/CT in the evaluation of skeletal malignancies and shows clinical examples illustrating the impact of SPECT/CT in improved localization and characterization of skeletal lesions. PMID:24715449

  10. I-123 Iofetamine SPECT scan in children with neurological disorders

    SciTech Connect

    Flamini, J.R.; Konkol, R.J.; Wells, R.G.; Sty, J.R. )

    1990-10-01

    I-123 Iofetamine (IMP) single photon emission computed tomography (SPECT) imaging of the brain in 42 patients (ages 14 days to 23 years) was compared with other localizing studies in children with neurological diseases. All had an EEG and at least one imaging study of the brain (computed tomography (CT) or magnetic resonance imaging (MRI), or both). Seventy-eight percent of the patients had an EEG within 24-72 hours of the IMP-SPECT scan. Thirty-five (83%) had a history of seizures, and the remainder had other neurological conditions without a history of seizures. In most cases, a normal EEG reading with normal CT or MRI result predicted a normal SPECT study. When the EEG was abnormal the majority of the IMP-SPECT scans were abnormal and localized the abnormality to the same region. A comparison with CT and MRI showed that structural abnormalities involving the cortex were usually well demonstrated with IMP-SPECT imaging. Structural lesions confined to the white matter were generally not detectable with IMP-SPECT. In a few cases, SPECT scans revealed abnormalities in deep brain areas not identified by EEG. IMP-SPECT imaging is a valuable technique for the detection and localization of abnormal cerebral metabolic activity in children with seizure disorders. A correlation with CT or MRI is essential for proper interpretation of abnormalities detected with IMP SPECT imaging.

  11. Modeling of the electron distribution based on bremsstrahlung emission during lower hybrid current drive on PLT

    SciTech Connect

    Stevens, J.E.; von Goeler, S.; Bernabei, S.; Bitter, M.; Chu, T.K.; Efthimion, P.; Fisch, N.; Hooke, W.; Hosea, J.; Jobes, F.

    1985-03-01

    Lower hybrid current drive requires the generation of a high energy electron tail anisotropic in velocity. Measurements of bremsstrahlung emission produced by this tail are compared with the calculated emission from reasonable model distributions. The physical basis and the sensitivity of this modeling process are described and the plasma properties of current driven discharges which can be derived from the model are discussed.

  12. Measurement of Z/sub eff/ profiles from bremsstrahlung emission in the near infrared

    SciTech Connect

    Roehr, H.; Steuer, K.H.; the ASDEX Team

    1988-08-01

    Local measurements of plasma radiation in the near infrared using the detection system of the ASDEX Thomson scattering device are reported. Comparison with hydrogen bremsstrahlung yields Z/sub eff/ profiles. Good agreement with values from other diagnostics is obtained. Z/sub eff/ behavior in a variety of ASDEX discharges is discussed.

  13. Pion-proton bremsstrahlung calculation and the experimental'' magnetic moment of. Delta. sup ++ (1232)

    SciTech Connect

    Lin, D.; Liou, M.K. ); Ding, Z.M. Department of Physics, Normandale Community College, Bloomington, Minnesota )

    1991-11-01

    A bremsstrahlung amplitude in the special two-energy-two-angle (TETAS) approximation, which is relativistic, gauge invariant, and consistent with the soft-photon theorem, is derived for the pion-proton bremsstrahlung ({pi}{sup +}{ital p}{gamma}) process near the {Delta}{sup ++}(1232) resonance. In order to take into account bremsstrahlung emission from an internal {Delta}{sup ++} line with both charge and the anomalous magnetic moment {lambda}{sub {Delta}}, we have applied a radiation decomposition identity to modify Low's standard prescription for constructing a soft-photon amplitude. This modified procedure is very general; it can be used to derive the TETAS amplitude for any bremsstrahlung process with resonance. The derived TETAS amplitude is applied to calculate all {pi}{sup +}{ital p}{gamma} cross sections which can be compared with the experimental data. Treating {lambda}{sub {Delta}} as a free parameter in these calculations, we extract the experimental'' magnetic moment of the {Delta}{sup ++}, {mu}{sub {Delta}}, from recent data. The extracted values of {mu}{sub {Delta}} are (3.7--4.2){ital e}/(2{ital m}{sub {ital p}}) from the University of California, Los Angeles data and (4.6--4.9){ital e}/(2{ital m}{sub {ital p}}) from the Paul Scherrer Institute data. Here, {ital m}{sub {ital p}} is the proton mass.

  14. The Gluckstern-Hull formula for electron-nucleus bremsstrahlung. Technical report

    SciTech Connect

    Brandt, H.E.

    1980-05-01

    The Gluckstern-Hull formula for the electron-nucleus bremsstrahlung cross section, containing the emitted photon angular dependence with the recoil electron angular dependence integrated out, is shown to be correct. This formula is required to calculate continuum x-ray spectra radiated from anisotropic relativistic beam-plasma systems.

  15. Hybrid SPECT/CT imaging in neurology.

    PubMed

    Ciarmiello, Andrea; Giovannini, Elisabetta; Meniconi, Martina; Cuccurullo, Vincenzo; Gaeta, Maria Chiara

    2014-01-01

    In recent years, the SPECT/CT hybrid modality has led to a rapid development of imaging techniques in nuclear medicine, opening new perspectives for imaging staff and patients as well. However, while, the clinical role of positron emission tomography-computed tomography (PET-CT) is well consolidated, the diffusion and the consequent value of single-photon emission tomography-computed tomography (SPECT-CT) has yet to be weighed, Hence, there is a need for a careful analysis, comparing the "potential" benefits of the hybrid modality with the "established" ones of the standalone machine. The aim of this article is to analyze the impact of this hybrid tool on the diagnosis of diseases of the central nervous system, comparing strengths and weaknesses of both modalities through the use of SWOT analysis. PMID:25143053

  16. SPECT/CT in pediatric patient management.

    PubMed

    Nadel, Helen R

    2014-05-01

    Hybrid SPECT/CT imaging is becoming the standard of care in pediatric imaging. Indications are mainly for oncologic imaging including mIBG scintigraphy for neuroblastoma and I-123 post surgical imaging of children with thyroid carcinoma, bone scintigraphy for back pain, children referred from sports medicine and neurodevelopmentally delayed children presenting with pain symptoms. The studies provide improved diagnostic accuracy, and oncologic imaging that includes optimized CT as part of the SPECT/CT study may decrease the number of studies and sedation procedures an individual child may need. The studies, however, must be tailored on an individual basis as the addition of the CT study can increase exposure to the child and should only be performed after appropriate justification and with adherence to optimized low dose pediatric protocols. PMID:24554052

  17. Accelerated GPU based SPECT Monte Carlo simulations.

    PubMed

    Garcia, Marie-Paule; Bert, Julien; Benoit, Didier; Bardiès, Manuel; Visvikis, Dimitris

    2016-06-01

    Monte Carlo (MC) modelling is widely used in the field of single photon emission computed tomography (SPECT) as it is a reliable technique to simulate very high quality scans. This technique provides very accurate modelling of the radiation transport and particle interactions in a heterogeneous medium. Various MC codes exist for nuclear medicine imaging simulations. Recently, new strategies exploiting the computing capabilities of graphical processing units (GPU) have been proposed. This work aims at evaluating the accuracy of such GPU implementation strategies in comparison to standard MC codes in the context of SPECT imaging. GATE was considered the reference MC toolkit and used to evaluate the performance of newly developed GPU Geant4-based Monte Carlo simulation (GGEMS) modules for SPECT imaging. Radioisotopes with different photon energies were used with these various CPU and GPU Geant4-based MC codes in order to assess the best strategy for each configuration. Three different isotopes were considered: (99m) Tc, (111)In and (131)I, using a low energy high resolution (LEHR) collimator, a medium energy general purpose (MEGP) collimator and a high energy general purpose (HEGP) collimator respectively. Point source, uniform source, cylindrical phantom and anthropomorphic phantom acquisitions were simulated using a model of the GE infinia II 3/8" gamma camera. Both simulation platforms yielded a similar system sensitivity and image statistical quality for the various combinations. The overall acceleration factor between GATE and GGEMS platform derived from the same cylindrical phantom acquisition was between 18 and 27 for the different radioisotopes. Besides, a full MC simulation using an anthropomorphic phantom showed the full potential of the GGEMS platform, with a resulting acceleration factor up to 71. The good agreement with reference codes and the acceleration factors obtained support the use of GPU implementation strategies for improving computational

  18. Accelerated GPU based SPECT Monte Carlo simulations

    NASA Astrophysics Data System (ADS)

    Garcia, Marie-Paule; Bert, Julien; Benoit, Didier; Bardiès, Manuel; Visvikis, Dimitris

    2016-06-01

    Monte Carlo (MC) modelling is widely used in the field of single photon emission computed tomography (SPECT) as it is a reliable technique to simulate very high quality scans. This technique provides very accurate modelling of the radiation transport and particle interactions in a heterogeneous medium. Various MC codes exist for nuclear medicine imaging simulations. Recently, new strategies exploiting the computing capabilities of graphical processing units (GPU) have been proposed. This work aims at evaluating the accuracy of such GPU implementation strategies in comparison to standard MC codes in the context of SPECT imaging. GATE was considered the reference MC toolkit and used to evaluate the performance of newly developed GPU Geant4-based Monte Carlo simulation (GGEMS) modules for SPECT imaging. Radioisotopes with different photon energies were used with these various CPU and GPU Geant4-based MC codes in order to assess the best strategy for each configuration. Three different isotopes were considered: 99m Tc, 111In and 131I, using a low energy high resolution (LEHR) collimator, a medium energy general purpose (MEGP) collimator and a high energy general purpose (HEGP) collimator respectively. Point source, uniform source, cylindrical phantom and anthropomorphic phantom acquisitions were simulated using a model of the GE infinia II 3/8" gamma camera. Both simulation platforms yielded a similar system sensitivity and image statistical quality for the various combinations. The overall acceleration factor between GATE and GGEMS platform derived from the same cylindrical phantom acquisition was between 18 and 27 for the different radioisotopes. Besides, a full MC simulation using an anthropomorphic phantom showed the full potential of the GGEMS platform, with a resulting acceleration factor up to 71. The good agreement with reference codes and the acceleration factors obtained support the use of GPU implementation strategies for improving computational efficiency

  19. High-power, photofission-inducing bremsstrahlung source for intense pulsed active detection of fissile material

    NASA Astrophysics Data System (ADS)

    Zier, J. C.; Mosher, D.; Allen, R. J.; Commisso, R. J.; Cooperstein, G.; Hinshelwood, D. D.; Jackson, S. L.; Murphy, D. P.; Ottinger, P. F.; Richardson, A. S.; Schumer, J. W.; Swanekamp, S. B.; Weber, B. V.

    2014-06-01

    Intense pulsed active detection (IPAD) is a promising technique for detecting fissile material to prevent the proliferation of special nuclear materials. With IPAD, fissions are induced in a brief, intense radiation burst and the resulting gamma ray or neutron signals are acquired during a short period of elevated signal-to-noise ratio. The 8 MV, 200 kA Mercury pulsed-power generator at the Naval Research Laboratory coupled to a high-power vacuum diode produces an intense 30 ns bremsstrahlung beam to study this approach. The work presented here reports on Mercury experiments designed to maximize the photofission yield in a depleted-uranium (DU) object in the bremsstrahlung far field by varying the anode-cathode (AK) diode gap spacing and by adding an inner-diameter-reducing insert in the outer conductor wall. An extensive suite of diagnostics was fielded to measure the bremsstrahlung beam and DU fission yield as functions of diode geometry. Delayed fission neutrons from the DU proved to be a valuable diagnostic for measuring bremsstrahlung photons above 5 MeV. The measurements are in broad agreement with particle-in-cell and Monte Carlo simulations of electron dynamics and radiation transport. These show that with increasing AK gap, electron losses to the insert and outer conductor wall increase and that the electron angles impacting the bremsstrahlung converter approach normal incidence. The diode conditions for maximum fission yield occur when the gap is large enough to produce electron angles close to normal, yet small enough to limit electron losses.

  20. Cubical S values for use with SPECT, PET, and autoradiographic imaging data in performing small-scale dosimetry

    SciTech Connect

    Costes, S.V.; Bouchet, L.G.; Bolch, W.E.

    1996-06-01

    A traditional assumption made in nuclear medicine dosimetry methodologies such as the MIRD schema is that the activity in the source organ is uniformly distributed. Localization techniques such as quantitative SPEC and PET imaging allow one to dispense with this assumption and look at realistic nonuniform activity distributions in selected organs or organ regions. Therapy applications further emphasize the need for direct treatment of nonuniformities. Many researchers have relied upon elaborate computational techniques such as dose kernels to assess dose distributions in these regions. In this work, a simplified approach is proposed which allows direct use of the MIRD schema in conjunction with imaging data to rapidly assess organ dose distributions with minimal computational effort. The EGS4 radiation transportcode has been used with a cubical array of tissue voxel elements for a centrally located source cube of {sup 32}P, {sup 131}I, {sup 89}Sr, {sup 90}Y, and {sup 99m}Tc. Three sets of voxel dimensions are considered: 6 mm for SPECT images, 3 mm for PET images, and 50 {mu}m for autoradiography. Radionuclide S values are subsequently tabulated as a single function of the source-to-target voxel separation distance. Isodose contours are shown for (1) a mouse renal cell carcinoma with {sup 131}I-labeled antibody, (2) a human colon adenocarcinoma with {sup 131}I-labeled antibody, and (3) various tumors directly injected With {sup 32}P.

  1. Reconstruction of dynamic gated cardiac SPECT

    SciTech Connect

    Jin Mingwu; Yang Yongyi; King, Michael A.

    2006-11-15

    In this paper we propose an image reconstruction procedure which aims to unify gated single photon emission computed tomography (SPECT) and dynamic SPECT into a single method. We divide the cardiac cycle into a number of gate intervals as in gated SPECT, but treat the tracer distribution for each gate as a time-varying signal. By using both dynamic and motion-compensated temporal regularization, our reconstruction procedure will produce an image sequence that shows both cardiac motion and time-varying tracer distribution simultaneously. To demonstrate the proposed reconstruction method, we simulated gated cardiac perfusion imaging using the gated mathematical cardiac-torso (gMCAT) phantom with Tc99m-Teboroxime as the imaging agent. Our results show that the proposed method can produce more accurate reconstruction of gated dynamic images than independent reconstruction of individual gate frames with spatial smoothness alone. In particular, our results show that the former could improve the contrast to noise ratio of a simulated perfusion defect by as much as 100% when compared to the latter.

  2. SPECT detectors: the Anger Camera and beyond

    PubMed Central

    Peterson, Todd E.; Furenlid, Lars R.

    2011-01-01

    The development of radiation detectors capable of delivering spatial information about gamma-ray interactions was one of the key enabling technologies for nuclear medicine imaging and, eventually, single-photon emission computed tomography (SPECT). The continuous NaI(Tl) scintillator crystal coupled to an array of photomultiplier tubes, almost universally referred to as the Anger Camera after its inventor, has long been the dominant SPECT detector system. Nevertheless, many alternative materials and configurations have been investigated over the years. Technological advances as well as the emerging importance of specialized applications, such as cardiac and preclinical imaging, have spurred innovation such that alternatives to the Anger Camera are now part of commercial imaging systems. Increased computing power has made it practical to apply advanced signal processing and estimation schemes to make better use of the information contained in the detector signals. In this review we discuss the key performance properties of SPECT detectors and survey developments in both scintillator and semiconductor detectors and their readouts with an eye toward some of the practical issues at least in part responsible for the continuing prevalence of the Anger Camera in the clinic. PMID:21828904

  3. SPECT detectors: the Anger Camera and beyond.

    PubMed

    Peterson, Todd E; Furenlid, Lars R

    2011-09-01

    The development of radiation detectors capable of delivering spatial information about gamma-ray interactions was one of the key enabling technologies for nuclear medicine imaging and, eventually, single-photon emission computed tomography (SPECT). The continuous sodium iodide scintillator crystal coupled to an array of photomultiplier tubes, almost universally referred to as the Anger Camera after its inventor, has long been the dominant SPECT detector system. Nevertheless, many alternative materials and configurations have been investigated over the years. Technological advances as well as the emerging importance of specialized applications, such as cardiac and preclinical imaging, have spurred innovation such that alternatives to the Anger Camera are now part of commercial imaging systems. Increased computing power has made it practical to apply advanced signal processing and estimation schemes to make better use of the information contained in the detector signals. In this review we discuss the key performance properties of SPECT detectors and survey developments in both scintillator and semiconductor detectors and their readouts with an eye toward some of the practical issues at least in part responsible for the continuing prevalence of the Anger Camera in the clinic. PMID:21828904

  4. SPECT detectors: the Anger Camera and beyond

    NASA Astrophysics Data System (ADS)

    Peterson, Todd E.; Furenlid, Lars R.

    2011-09-01

    The development of radiation detectors capable of delivering spatial information about gamma-ray interactions was one of the key enabling technologies for nuclear medicine imaging and, eventually, single-photon emission computed tomography (SPECT). The continuous sodium iodide scintillator crystal coupled to an array of photomultiplier tubes, almost universally referred to as the Anger Camera after its inventor, has long been the dominant SPECT detector system. Nevertheless, many alternative materials and configurations have been investigated over the years. Technological advances as well as the emerging importance of specialized applications, such as cardiac and preclinical imaging, have spurred innovation such that alternatives to the Anger Camera are now part of commercial imaging systems. Increased computing power has made it practical to apply advanced signal processing and estimation schemes to make better use of the information contained in the detector signals. In this review we discuss the key performance properties of SPECT detectors and survey developments in both scintillator and semiconductor detectors and their readouts with an eye toward some of the practical issues at least in part responsible for the continuing prevalence of the Anger Camera in the clinic.

  5. Methodology for ventilation/perfusion SPECT.

    PubMed

    Bajc, Marika; Neilly, Brian; Miniati, Massimo; Mortensen, Jan; Jonson, Björn

    2010-11-01

    Ventilation/perfusion single-photon emission computed tomography (V/Q SPECT) is the scintigraphic technique of choice for the diagnosis of pulmonary embolism and many other disorders that affect lung function. Data from recent ventilation studies show that the theoretic advantages of Technegas over radiolabeled liquid aerosols are not restricted to the presence of obstructive lung disease. Radiolabeled macroaggregated human albumin is the imaging agent of choice for perfusion scintigraphy. An optimal combination of nuclide activities and acquisition times for ventilation and perfusion, collimators, and imaging matrix yields an adequate V/Q SPECT study in approximately 20 minutes of imaging time. The recommended protocol based on the patient remaining in an unchanged position during the initial ventilation study and the perfusion study allows presentation of matching ventilation and perfusion slices in all projections as well as in rotating volume images based upon maximum intensity projections. Probabilistic interpretation of V/Q SPECT should be replaced by a holistic interpretation strategy on the basis of all relevant information about the patient and all ventilation/perfusion patterns. PE is diagnosed when there is more than one subsegment showing a V/Q mismatch representing an anatomic lung unit. Apart from pulmonary embolism, other pathologies should be identified and reported, for example, obstructive disease, heart failure, and pneumonia. Pitfalls exist both with respect to imaging technique and scan interpretation. PMID:20920632

  6. FDG cardiac SPECT versus PET: Relation to SPECT radionuclide angiography and thallium scintigraphy

    SciTech Connect

    Srinivasan, G.; Kitsiou, A.N.; Bacharach, S.L.

    1996-05-01

    To determine whether fluorodeoxyglucose (FDG) imaging with SPECT, using high-energy collimation, provides comparable viability information to FDG-PET, 16 pts with chronic CAD undergoing FDG-PET studies were reimaged with SPECT immediately after the PET acquisition was completed. All pts had stress (S)-redistribution (RD)-reinjection (RI) thallium (TL) studies and a subset of 12 pts had SPECT radionuclide angiography (RNA). The LV was divided into 4 long-axis tomograms encompassing the entire LV and the myocardial activity of 11 sectors per tomogram was assessed quantitatively. The mean counts per pixel of corresponding FDG-SPECT, FDG-PET, RD and RI-TL images were normalized to that sector having peak activity on TL-S and compared on the basis of severity of reduction in FDG and TL activity as follows: normal (NI = >85% of peak), mild-moderate (50-86%) and severe (<50%). FDG-SPECT provided concordant viability information with FDG-PET (NI/mild-mod vs severe) in 581 of 615 (94%) sectors and with TL S-RD-RI(NI/reversible/mild-mod vs severe irreversible) in 555 or 615 (90%) sectors. To facilitate comparison of FDG and TK uptake with regional contraction, these sectors were grouped into 5 regions (anterior, septal, apex, inferior and lateral). These data suggest that most normal/HK regions are viable both by FDG and TL. Among a total of 33 sHK and AK/DK regions, in which viability is a clinical concern, 17 (52%) were viable by TL, 22 (67%) by FDG-SPECT and 24 (73%) by FDG-PET (p=NS). These data suggest that most normal/HK regions are viable both by FDG and TL. Among a total of 33 sHK and AK/DK regions, in which viability is a clinical concern, 17 (52%) were viable by TL, 22 (67%) by FDG-SPECT and 24 (73%) by FDG-PET (p=NS). These data affirm the good overall correlation between FDG uptake and TL for differentiating viable from nonviable myocardium in asynergic regions regardless of the technology applied, PET or SPECT.

  7. SPECT data acquisition and image reconstruction in a stationary small animal SPECT/MRI system

    NASA Astrophysics Data System (ADS)

    Xu, Jingyan; Chen, Si; Yu, Jianhua; Meier, Dirk; Wagenaar, Douglas J.; Patt, Bradley E.; Tsui, Benjamin M. W.

    2010-04-01

    The goal of the study was to investigate data acquisition strategies and image reconstruction methods for a stationary SPECT insert that can operate inside an MRI scanner with a 12 cm bore diameter for simultaneous SPECT/MRI imaging of small animals. The SPECT insert consists of 3 octagonal rings of 8 MR-compatible CZT detectors per ring surrounding a multi-pinhole (MPH) collimator sleeve. Each pinhole is constructed to project the field-of-view (FOV) to one CZT detector. All 24 pinholes are focused to a cylindrical FOV of 25 mm in diameter and 34 mm in length. The data acquisition strategies we evaluated were optional collimator rotations to improve tomographic sampling; and the image reconstruction methods were iterative ML-EM with and without compensation for the geometric response function (GRF) of the MPH collimator. For this purpose, we developed an analytic simulator that calculates the system matrix with the GRF models of the MPH collimator. The simulator was used to generate projection data of a digital rod phantom with pinhole aperture sizes of 1 mm and 2 mm and with different collimator rotation patterns. Iterative ML-EM reconstruction with and without GRF compensation were used to reconstruct the projection data from the central ring of 8 detectors only, and from all 24 detectors. Our results indicated that without GRF compensation and at the default design of 24 projection views, the reconstructed images had significant artifacts. Accurate GRF compensation substantially improved the reconstructed image resolution and reduced image artifacts. With accurate GRF compensation, useful reconstructed images can be obtained using 24 projection views only. This last finding potentially enables dynamic SPECT (and/or MRI) studies in small animals, one of many possible application areas of the SPECT/MRI system. Further research efforts are warranted including experimentally measuring the system matrix for improved geometrical accuracy, incorporating the co

  8. Bremsstrahlung and photoneutron production in a steel shield for 15-22-MeV clinical electron beams.

    PubMed

    Fujita, Yukio; Myojoyama, Atsushi; Saitoh, Hidetoshi

    2015-02-01

    The physical data regarding bremsstrahlung and neutrons produced in a steel shield by high-energy electron beams from a medical linear accelerator were investigated. These data are required to allow the accurate prediction of shielding performance for high-energy electron beams and in the design of radiotherapy facilities. A Monte Carlo code was used to develop Monte Carlo beam models for clinical electron beams and to directly simulate bremsstrahlung and secondary neutron production in a steel shield. The effective dose and dose equivalent of bremsstrahlung X rays and secondary neutrons outside a vault were determined using a realistic radiation source. The accuracy of Monte Carlo simulations was validated experimentally by comparing the measured and calculated physical quantities. In validating the Monte Carlo simulation, the measured and calculated values showed reasonable agreement, indicating that bremsstrahlung and photoneutron production and transport were simulated accurately. The bremsstrahlung X-ray dose was the main component of the total dose outside a vault. The secondary neutron dose was 1-20 % of the bremsstrahlung X-ray dose, but the neutron dose was also at a non-negligible level. The calculated neutron dose outside the vault differed from the McGinley's reported data. These results indicate that McGinley's method overestimates the neutron dose beyond the steel shield. The physical data used here will be useful in the accurate estimation of bremsstrahlung X-ray and neutron doses for high-energy electron beams. PMID:24821930

  9. The use of Yttrium-90 Ibritumomab Tiuxetan (90Y-IT) as a consolidation therapy in high-risk patients with diffuse large B-cell lymphoma ineligible for autologous stem-cell transplantation

    PubMed Central

    Kisiel, Elżbieta; Sawczuk-Chabin, Joanna; Centkowski, Piotr; Knopińska-Posłuszny, Wanda; Khan, Omeir

    2015-01-01

    Aim of the study To evaluate the efficacy and safety of Yttrium-90 Ibritumomab Tiuxetan (90Y-IT) as a consolidation therapy in the management of DLBCL. Material and methods Patients with primary refractory or high-risk DLBCL (n = 18), ineligible for autologous stem-cell transplantation, were included in a retrospective study performed at three centers by the Polish Lymphoma Research Group (PLRG). All patients (mean age 61, range 35–82) either didn't achieve a complete response or didn't complete the scheduled therapy due to its complications. Response rates (CR, PR, SD, PD) according to Cheson criteria, overall survival (OS), progression-free survival (PFS) and adverse effects of radioimmunotherapy were analyzed. Results Consolidation radioimmunotherapy increased the CR rate from 38% (n = 7) to 82% (n = 15). One patient remained in PR, one patient remained in SD, while one patient remained in PD. During a median follow-up of five years, 11 patients (62%) were alive with no recurrence, 4 patients (22%) were alive with relapse while 3 patients (16%) died. There was no statistically significant difference in PFS between those in CR and those in PR before 90Y-IT. Conclusions Radioimmunotherapy is an effective consolidation therapy for high risk/refractory DLBCL patients and worthy of further investigation in prospective trials. PMID:26199570

  10. Mechanism and energetics for complexation of {sup 90}Y with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), a model for cancer radioimmunotherapy

    SciTech Connect

    Jang, Y.H.; Blanco, M.; Dasgupta, S.; Keire, D.A.; Shively, J.E.; Goddard, W.A. III

    1999-07-07

    A promising cancer therapy involves the use of the macrocyclic polyaminoacetate DOTA (1,4,6,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) attached to a tumor-targeting antibody complexed with the {beta} emitter {sup 90}Y{sup 3+}. However, incorporation of the {sup 90}Y into the DOTA conjugate is too slow. To identify the origins of this problem, ab initio quantum chemistry methods (B3LYP/:ACVP* and HF/LACVP*) were used to predict structures and energetics. The authors find that the initial complex YH{sub 2}(DOTA){sup +} is 4-coodinate (the four equivalent carboxylate oxygens), which transforms to YH(DOTA) (5-coordinate with one ring N and four carboxylate oxygens), and finally to Y(DOTA){sup {minus}}, which is 8-coordinate (four oxygens and four nitrogens). The rate-determining step is the conversion of YH(DOTA) to Y(DOTA){sup {minus}}, which was calculated to have an activation free energy (aqueous phase) of 8.4 kcal/mol, in agreement with experimental results (8.1--9.3 kcal/mol) for various metals to DOTA [Kumar, K.; Tweedle, M.F. Inorg. Chem. 1993, 32, 4193--4199; Wu, S.L.; Horrocks, W.D., Jr., Inorg. Chem. 1995, 34, 3724--2732]. On the basis of this mechanism the authors propose a modified chelate, DO3AlPr, which has calculated at a much faster rate of incorporation.

  11. Design and assessment of cardiac SPECT systems

    NASA Astrophysics Data System (ADS)

    Lee, Chih-Jie

    Single-photon emission computed tomography (SPECT) is a modality widely used to detect myocardial ischemia and myocardial infarction. Objectively assessing and comparing different SPECT systems is important so that the best detectability of cardiac defects can be achieved. Whitaker, Clarkson, and Barrett's study on the scanning linear observer (SLO) shows that the SLO can be used to estimate the location and size of signals. One major advantage of the SLO is that it can be used with projection data rather than reconstruction data. Thus, this observer model assesses overall hardware performance independent by any reconstruction algorithm. In addition, we will show that the run time of image-quality studies is significantly reduced. Several systems derived from the GE CZT-based dedicated cardiac SPECT camera Discovery 530c design, which is officially named the Alcyone Technology: Discovery NM 530c, were assessed using the performance of the SLO for the task of detecting cardiac defects and estimating the properties of the defects. Clinically, hearts can be virtually segmented into three coronary artery territories: left anterior descending artery (LAD), left circumflex artery (LCX), and right coronary artery (RCA). One of the most important functions of a cardiac SPECT system is to produce images from which a radiologist can correctly predict in which territory the defect exists. A good estimation of the defect extent from the images is also very helpful for determining the seriousness of the myocardial ischemia. In this dissertation, both locations and extent of defects were estimated by the SLO, and system performance was assessed using localization receiver operating characteristic (LROC) / estimation receiver operating characteristic (EROC) curves. Area under LROC curve (AULC) / area under EROC curve (AUEC) and true positive fraction (TPF) at specific false positive fraction (FPF) can be treated as the gures of merit (FOMs). As the results will show, a

  12. Quantitative Monte Carlo-based holmium-166 SPECT reconstruction

    SciTech Connect

    Elschot, Mattijs; Smits, Maarten L. J.; Nijsen, Johannes F. W.; Lam, Marnix G. E. H.; Zonnenberg, Bernard A.; Bosch, Maurice A. A. J. van den; Jong, Hugo W. A. M. de; Viergever, Max A.

    2013-11-15

    Purpose: Quantitative imaging of the radionuclide distribution is of increasing interest for microsphere radioembolization (RE) of liver malignancies, to aid treatment planning and dosimetry. For this purpose, holmium-166 ({sup 166}Ho) microspheres have been developed, which can be visualized with a gamma camera. The objective of this work is to develop and evaluate a new reconstruction method for quantitative {sup 166}Ho SPECT, including Monte Carlo-based modeling of photon contributions from the full energy spectrum.Methods: A fast Monte Carlo (MC) simulator was developed for simulation of {sup 166}Ho projection images and incorporated in a statistical reconstruction algorithm (SPECT-fMC). Photon scatter and attenuation for all photons sampled from the full {sup 166}Ho energy spectrum were modeled during reconstruction by Monte Carlo simulations. The energy- and distance-dependent collimator-detector response was modeled using precalculated convolution kernels. Phantom experiments were performed to quantitatively evaluate image contrast, image noise, count errors, and activity recovery coefficients (ARCs) of SPECT-fMC in comparison with those of an energy window-based method for correction of down-scattered high-energy photons (SPECT-DSW) and a previously presented hybrid method that combines MC simulation of photopeak scatter with energy window-based estimation of down-scattered high-energy contributions (SPECT-ppMC+DSW). Additionally, the impact of SPECT-fMC on whole-body recovered activities (A{sup est}) and estimated radiation absorbed doses was evaluated using clinical SPECT data of six {sup 166}Ho RE patients.Results: At the same noise level, SPECT-fMC images showed substantially higher contrast than SPECT-DSW and SPECT-ppMC+DSW in spheres ≥17 mm in diameter. The count error was reduced from 29% (SPECT-DSW) and 25% (SPECT-ppMC+DSW) to 12% (SPECT-fMC). ARCs in five spherical volumes of 1.96–106.21 ml were improved from 32%–63% (SPECT-DSW) and 50%–80

  13. A small-animal imaging system capable of multipinhole circular/helical SPECT and parallel-hole SPECT

    PubMed Central

    Qian, Jianguo; Bradley, Eric L.; Majewski, Stan; Popov, Vladimir; Saha, Margaret S.; Smith, Mark F.; Weisenberger, Andrew G.; Welsh, Robert E.

    2008-01-01

    We have designed and built a small animal single photon emission computed tomography (SPECT) imaging system equipped with parallel-hole and multipinhole collimators and capable of circular or helical SPECT. Copper-beryllium parallel-hole collimators suitable for imaging the ~35 keV photons from the decay of 125I have been built and installed to achieve useful spatial resolution over a range of object-detector distances and to reduce imaging time on our dual-detector array. To address the resolution limitations in the parallel-hole SPECT and the sensitivity and limited field of view of single-pinhole SPECT, we have incorporated multipinhole circular and helical SPECT in addition to expanding the parallel-hole SPECT capabilities. The pinhole SPECT system is based on a 110 mm diameter circular detector equipped with a pixellated NaI(Tl) scintillator array (1×1×5 mm3/pixel). The helical trajectory is accomplished by two stepping motors controlling the rotation of the detector-support gantry and displacement of the animal bed along the axis of rotation of the gantry. Results obtained in SPECT studies of various phantoms show an enlarged field of view, very good resolution and improved sensitivity using multipinhole circular or helical SPECT. Collimators with one, three and five 1 mm diameter pinholes have been implemented and compared in these tests. Our objective is to develop a system on which one may readily select a suitable mode of either parallel-hole SPECT or pinhole circular or helical SPECT for a variety of small animal imaging applications. PMID:19701447

  14. A small-animal imaging system capable of multipinhole circular/helical SPECT and parallel-hole SPECT

    NASA Astrophysics Data System (ADS)

    Qian, Jianguo; Bradley, Eric L.; Majewski, Stan; Popov, Vladimir; Saha, Margaret S.; Smith, Mark F.; Weisenberger, Andrew G.; Welsh, Robert E.

    2008-08-01

    We have designed and built a small-animal single-photon emission computed tomography (SPECT) imaging system equipped with parallel-hole and multipinhole collimators and capable of circular or helical SPECT. Copper-beryllium parallel-hole collimators suitable for imaging the ˜35 keV photons from the decay of 125I have been built and installed to achieve useful spatial resolution over a range of object-detector distances and to reduce imaging time on our dual-detector array. To address the resolution limitations in the parallel-hole SPECT and the sensitivity and limited field of view of single-pinhole SPECT, we have incorporated multipinhole circular and helical SPECT in addition to expanding the parallel-hole SPECT capabilities. The pinhole SPECT system is based on a 110 mm diameter circular detector equipped with a pixellated NaI(Tl) scintillator array (1×1×5 mm 3/pixel). The helical trajectory is accomplished by two stepping motors controlling the rotation of the detector-support gantry and displacement of the animal bed along the axis of rotation of the gantry. Results obtained in SPECT studies of various phantoms show an enlarged field of view, very good resolution and improved sensitivity using multipinhole circular or helical SPECT. Collimators with one, three and five, 1-mm-diameter pinholes have been implemented and compared in these tests. Our objective is to develop a system on which one may readily select a suitable mode of either parallel-hole SPECT or pinhole circular or helical SPECT for a variety of small animal imaging applications.

  15. Interobserver variation in diagnosis of dementia by brain perfusion SPECT.

    PubMed

    Honda, Norinari; Machida, Kikuo; Hosono, Makoto; Matsumoto, Tohru; Matsuda, Hiroshi; Oshima, Motoo; Koizumi, Kiyoshi; Kosuda, Shigeru; Momose, Toshimitsu; Mori, Yutaka; Hashimoto, Jun; Shimizu, Yuji

    2002-01-01

    Brain perfusion SPECT (BP-SPECT) has characteristic patterns of abnormality, enabling the differential diagnosis of dementia. The purpose of this study was to measure interobserver variations in the diagnosis of dementia using BP-SPECT. BP-SPECT images of 57 cases, 19 of Alzheimer's disease (AD), eight of multi-infarct dementia (MID), three of Pick's disease, five of other dementias, and 22 normal controls, were interpreted by ten nuclear medicine physicians with varying levels of experience. Brain MR images of the cases were then interpreted apart from SPECT. The physicians independently rated all of the diagnoses listed beforehand according to a five-point scale, with clinical information provided. Receiver-operating characteristic (ROC) curves and the area under the ROC curve (Az) were calculated. Az varied from 0.48 to 0.87. Mean Az's were significantly larger (p<0.05) in the diagnosis by SPECT than in that by MRI (0.715 and 0.629 for dementia vs. normal, 0.670 and 0.560 for AD or MID vs. normal, 0.610 and 0.416 for AD vs. normal, and 0.672 and 0.412 for AD vs. MID, respectively). Considerable interobserver variation was present in BP-SPECT interpretation. BP-SPECT may be more effective for the evaluation of dementia than MRI when the same nuclear medicine physicians interpret both images. PMID:12553341

  16. Patient doses from hybrid SPECT-CT procedures.

    PubMed

    Avramova-Cholakova, S; Dimcheva, M; Petrova, E; Garcheva, M; Dimitrova, M; Palashev, Y; Vassileva, J

    2015-07-01

    The aim of this work is to estimate patient doses from hybrid single-photon emission computed tomography (SPECT) and computed tomography (CT) procedures. The study involved all four SPECT-CT systems in Bulgaria. Effective dose was estimated for about 100 patients per system. Ten types of examinations were considered, representing all diagnostic procedures performed in the SPECT-CT systems. Effective doses from the SPECT component were calculated applying the ICRP 53 and ICRP 80 conversion coefficients. Computed tomography dose index and dose length product were retrospectively obtained from the archives of the systems, and effective doses from the CT component were calculated with CT-Expo software. Parallel estimation of CT component contribution with the National Radiological Protection Board (NRPB) conversion coefficients was performed where applicable. Large variations were found in the current practice of SPECT-CT imaging. Optimisation actions and diagnostic reference levels were proposed. PMID:25862537

  17. Single photon emission computed tomography (SPECT) in epilepsy

    SciTech Connect

    Leroy, R.F.

    1991-12-31

    Epilepsy is a common neurologic disorder which has just begun to be studied with single photon emission computerized tomography (SPECT). Epilepsy usually is studied with electroencephalographic (EEG) techniques that demonstrate the physiologic changes that occur during seizures, and with neuroimaging techniques that show the brain structures where seizures originate. Neither method alone has been adequate to describe the pathophysiology of the patient with epilepsy. EEG techniques lack anatomic sensitivity, and there are no structural abnormalities shown by neuroimaging which are specific for epilepsy. Functional imaging (FI) has developed as a physiologic tool with anatomic sensitivity, and SPECT has been promoted as a FI technique because of its potentially wide availability. However, SPECT is early in its development and its clinical utility for epilepsy still has to be demonstrated. To understand this role of SPECT, consideration must be given to the pathophysiology of epilepsy, brain physiology, types of seizure, epileptic syndromes, and the SPECT technique itself. 44 refs., 2 tabs.

  18. System Integration of FastSPECT III, a Dedicated SPECT Rodent-Brain Imager Based on BazookaSPECT Detector Technology

    PubMed Central

    Miller, Brian W.; Furenlid, Lars R.; Moore, Stephen K.; Barber, H. Bradford; Nagarkar, Vivek V.; Barrett, Harrison H.

    2010-01-01

    FastSPECT III is a stationary, single-photon emission computed tomography (SPECT) imager designed specifically for imaging and studying neurological pathologies in rodent brain, including Alzheimer’s and Parkinsons’s disease. Twenty independent BazookaSPECT [1] gamma-ray detectors acquire projections of a spherical field of view with pinholes selected for desired resolution and sensitivity. Each BazookaSPECT detector comprises a columnar CsI(Tl) scintillator, image-intensifier, optical lens, and fast-frame-rate CCD camera. Data stream back to processing computers via firewire interfaces, and heavy use of graphics processing units (GPUs) ensures that each frame of data is processed in real time to extract the images of individual gamma-ray events. Details of the system design, imaging aperture fabrication methods, and preliminary projection images are presented. PMID:21218137

  19. An Investigation of Bremsstrahlung Reflection in a Dense Plasma Focus (DPF) Propulsion Device

    SciTech Connect

    Thomas, Robert; Miley, G. H.; Mead, Franklin

    2006-01-20

    The dense plasma focus device is one of the few fusion systems that is capable of burning advanced fuels such as D - 3He and p - 11B. An study has been performed and shown that three main requirements must be satisfied to reach breakeven for DPF fusion: a high Ti/Te ration ({approx} 20), an order of magnitude higher pinch lifetime, and the reflection and absorption if at least 50% Bremsstrahlung radiation. The latter issue is the focus of this report, and a literature search has been performed on laser-driven fusion radiation cavities, multilayer reflectors, and their application to Bremsstrahlung radiation reflection is presented. Additionally, the results found are compared to those assumed in the earlier DPF study bring p-11B.

  20. Electron accelerator-based production of molybdenum-99: Bremsstrahlung and photoneutron generation from molybdenum vs. tungsten

    NASA Astrophysics Data System (ADS)

    Tsechanski, A.; Bielajew, A. F.; Archambault, J. P.; Mainegra-Hing, E.

    2016-01-01

    A new "one-stage" approach for production of 99Mo and other radioisotopes by means of an electron linear accelerator is described. It is based on using a molybdenum target both as a bremsstrahlung converter and as a radioisotope producing target for the production of 99Mo via the photoneutron reaction 100Mo(γ,n)99Mo. Bremsstrahlung characteristics, such as bremsstrahlung efficiency, angular distribution, and energy deposition for molybdenum targets were obtained by means of the EGSnrc Monte Carlo simulation code system. As a result of our simulations, it is concluded that a 60 MeV electron beam incident on a thick Mo target will have greater bremsstrahlung efficiency than the same thickness (in units of r0) W target, for target thickness z > 1.84r0, where r0 is the electron range. A 50 MeV electron beam incident on a Mo target will result in greater bremsstrahlung efficiency than the same thickness W target (in units of r0) for target thickness case: z ⩾ 2.0r0. It is shown for the one-stage approach with thicknesses of (1.84-2.0)r0, that the 99Mo-production bremsstrahlung efficiency of a molybdenum target is greater by ∼100% at 30 MeV and by ∼70% at 60 MeV compared to the values for tungsten of the same thickness (in units of the appropriate r0) in the traditional two-stage approach (W converter and separate 99Mo producing target). This advantage of the one-stage approach arises from the fact that the bremsstrahlung produced is attenuated only once from attenuation in the molybdenum converter/target. In the traditional, two-stage approach, the bremsstrahlung generated in the W-converter/target is attenuated both in the converter in the 99Mo-producing molybdenum target. The photoneutron production yield of molybdenum and tantalum (as a substitute for tungsten) target was calculated by means of the MCNP5 transport code. On the basis of these data, the specific activity for the one-stage approach of three enriched 100Mo-targets of a 2 cm diameter and

  1. Bayesian analysis of the effective charge from spectroscopic bremsstrahlung measurement in fusion plasmas

    NASA Astrophysics Data System (ADS)

    Krychowiak, M.; König, R.; Klinger, T.; Fischer, R.

    2004-11-01

    At the stellarator Wendelstein 7-AS (W7-AS) a spectrally resolving two channel system for the measurement of line-of-sight averaged Zeff values has been tested in preparation for its planned installation as a multichannel Zeff-profile measurement system on the stellarator Wendelstein 7-X (W7-X) which is presently under construction. The measurement is performed using the bremsstrahlung intensity in the wavelength region of ultraviolet to near infrared. The spectrally resolved measurement allows to eliminate signal contamination by line radiation. For statistical data analysis a procedure based on Bayesian probability theory has been developed. With this method it is possible to estimate the bremsstrahlung background in the measured signal and its error without the necessity to fit the spectral lines. For evaluation of the random error in Zeff the signal noise has been investigated. Furthermore, the linearity and behavior of the charge-coupled device detector at saturation has been analyzed.

  2. Determination of the temperature of bremsstrahlung photon generated by ultraintense laser using various thickness attenuators

    SciTech Connect

    Hasegawa, Shuichi; Takashima, Ryuta; Todoriki, Masaru; Kikkawa, Satoshi; Soda, Keita; Takano, Kei; Oishi, Yuji; Nayuki, Takuya; Fujii, Takashi; Nemoto, Koshichi

    2011-03-15

    We evaluate the simplified method using the Lambert-Beer law to measure the temperature of bremsstrahlung photon generated by an ultraintense laser. Analytical values are compared to the results of the Monte Carlo calculation of GEANT4 and they agreed very well on the condition of the appropriate distance between the attenuator and the detector. We performed the experiment to measure the temperature of bremsstrahlung x-ray emitted from a metal target irradiated by a Ti:sapphire laser with 76 mJ, 72 fs, 2.2 x 10{sup 18} W/cm{sup 2}. For a Cu target of 30 {mu}m thick, the photon temperature was reasonably determined to be 0.18 MeV, which is in good agreement with previous studies.

  3. Characteristics of a contract electron beam and bremsstrahlung (X-ray) irradiation facility of Radia industry

    NASA Astrophysics Data System (ADS)

    Takehisa, Masaaki; Saito, Toshio; Takahashi, Thoru; Sato, Yoshishige; Sato, Toshio

    1993-07-01

    A contract electron beam(EB) and bremsstrahlung(X-ray) facility with use of NHV 5 MeV, 30 mA Cock-Croft Walton machine is operational for EB since April 1991, and X-ray commercial irradiation was started in 1992 summer. The facility is consisted of the EB machine, bremsstrahlung target, chain and roller conveyor, and automatic turnover machine for dual sided irradiation. The operation of the system is fully controlled by LAN of personal computers for client's order, EB characteristics, beam current control proportional to the conveyor speed, turnover of product in processing mid point, and output of processing record to clients. The control and recording systems avoid human errors. This paper mainly discusses X-ray processing.

  4. An instrument for the investigation of actinides with spin resolved photoelectron spectroscopy and bremsstrahlung isochromat spectroscopy

    SciTech Connect

    Yu, S.-W.; Tobin, J. G.; Chung, B. W.

    2011-01-01

    A new system for spin resolved photoelectron spectroscopy and bremsstrahlung isochromat spectroscopy has been built and commissioned at Lawrence Livermore National Laboratory for the investigation of the electronic structure of the actinides.Actinide materials are very toxic and radioactive and therefore cannot be brought to most general user facilities for spectroscopic studies. The technical details of the new system and preliminary data obtained therein will be presented and discussed.

  5. Inner bremsstrahlung as a source of X-rays in the steady-state universe.

    NASA Technical Reports Server (NTRS)

    Petrosian, V.; Ramaty, R.

    1972-01-01

    Consideration of the compatibility of matter creation in steady-state cosmology with certain X-ray observations. It is shown that, because of inner bremsstrahlung from neutron decay, the steady-state universe with neutron creation in diffuse regions is inconsistent with X-ray observations around 100 keV, unless the particle density of the universe is less than 0.1 per cu m.

  6. Non-Abelian bremsstrahlung and azimuthal asymmetries in high energy p+A reactions

    NASA Astrophysics Data System (ADS)

    Gyulassy, M.; Levai, P.; Vitev, I.; Biró, T. S.

    2014-09-01

    We apply the GLV reaction operator solution to the Vitev-Gunion-Bertsch (VGB) boundary conditions to compute to all orders in nuclear opacity the non-Abelian gluon bremsstrahlung of event-by-event fluctuating beam jets in nuclear collisions. We evaluate analytically azimuthal Fourier moments of single gluon, vnM{1}, and even numbered 2ℓ gluon distribution, vnM{2ℓ}, inclusive distributions in high-energy p +A reactions as a function of harmonic n, target recoil cluster number, M, and gluon number, 2ℓ, at the RHIC and LHC. Multiple resolved clusters of recoiling target beam jets together with the projectile beam jet form color scintillation antenna (CSA) arrays that lead to characteristic boost-noninvariant trapezoidal rapidity distributions in asymmetric B+A nuclear collisions. The scaling of the intrinsically azimuthally anisotropic and long range in η nature of the non-Abelian bremsstrahlung leads to vn moments that are similar to results from hydrodynamic models, but due entirely to non-Abelian wave interference phenomena sourced by the fluctuating CSA. Our analytic nonflow solutions are similar to recent numerical saturation model predictions but differ by predicting a simple power-law hierarchy of both even and odd vn without invoking kT factorization. A test of the CSA mechanism is the predicted nearly linear η rapidity dependence of the vn(kT,η). Non-Abelian beam jet bremsstrahlung may, thus, provide a simple analytic solution to the beam energy scan puzzle of the near √s independence of vn(pT) moments observed down to 10 AGeV, where large-x valence-quark beam jets dominate inelastic dynamics. Recoil bremsstrahlung from multiple independent CSA clusters could also provide a partial explanation for the unexpected similarity of vn in p(D)+A and noncentral A+A at the same dN/dη multiplicity as observed at the RHIC and LHC.

  7. Measurements of bremsstrahlung produced by energetic electron bombardment of thick targets - II

    SciTech Connect

    Bauer, R.W.; Becker, J.A.; Farley, W.E.

    1987-07-01

    Samples of C (carbon), Al (aluminum), Fe (iron), and U (uranium), 1 inch thick, together with composite samples C/Al, and C/Al,U, have been bombrded by electrons of energy E/sub e/ = 40, 60, and 84 MeV. A status report of measurements of the thick-target bremsstrahlung for angles of 83.5, 96 and 107 degrees is presented.

  8. High level tritiated water monitoring by Bremsstrahlung counting using a silicon drift detector

    SciTech Connect

    Niemes, S.; Sturm, M.; Michling, R.; Bornschein, B.

    2015-03-15

    The β-ray induced X-ray spectrometry (BIXS) is a promising technique to monitor the tritium concentration in a fuel cycle of a fusion reactor. For in-situ measurements of high level tritiated water by Bremsstrahlung counting, the characteristics of a low-noise silicon drift detector (SDD) have been examined at the Tritium Laboratory Karlsruhe (TLK). In static measurements with constant sample volume and tritium concentration, the Bremsstrahlung spectra of tritiated water samples in a concentration range of 0.02 to 15 MBq/ml have been obtained. The volume has been kept constant at 5 cm{sup 3}. The observed spectra are well above the noise threshold. In addition to X-rays induced by β-rays, the spectra feature X-ray fluorescence peaks of the surrounding materials. No indications of memory effects have been observed. A linear relation between the X-ray intensity and the tritium concentration was obtained and the lower detection limit of the setup has been determined to 1 MBq ml{sup -1}, assessed by the Curie criterion. In addition, the spectra obtained experimentally could be reproduced with high agreement by Monte-Carlo simulations using the GEANT4-tool-kit. It was found that the present detection system is applicable to non-invasive measurements of high-level tritiated water and the SDD is a convenient tool to detect the low energy Bremsstrahlung X-rays. (authors)

  9. Impact of gas bremsstrahlung on synchrotron radiation beamline shielding at the Advanced Photon Source

    SciTech Connect

    Ipe, N.E.; Fasso, A.

    1994-01-01

    The Advanced Photon Source (APS) currently under construction at Argonne National Laboratory will be one of the world`s brightest synchrotron radiation facilities. The storage ring, capable of storing currents up to 300 mA at 7.0 GeV and 200 mA at 7.5 GeV, will produce very intense and energetic synchrotron radiation (E{sub c} = 24 keV for bending magnets and E{sub c} = 37.4 keV for wigglers, where E{sub c} is the critical energy). The synchrotron radiation (SR) beam lines consisting of experimental enclosures and transport lines will have to be shielded against synchrotron radiation and gas bremsstrahlung scattered from beam line components. For insertion devices placed in the straight sections (length = 15 m), the gas bremsstrahlung produced by the interaction of the primary stored beam with residual gas molecules or ions in the storage ring vacuum chamber dominates the SR beam line shielding. The impact of gas bremsstrahlung on the SR beam line shielding is discussed in this paper.

  10. On a discrete symmetry of the Bremsstrahlung function in {N} = 4 SYM

    NASA Astrophysics Data System (ADS)

    Beccaria, Matteo; Macorini, Guido

    2013-07-01

    We consider the quark anti-quark potential on the three sphere in planar {N} = 4 SYM and the associated vacuum potential in the near BPS limit with L units of R-charge. The associated Bremsstrahlung function B L has been recently computed analytically by means of the Thermodynamical Bethe Ansatz. We discuss it at strong coupling by computing it at large but finite L. We provide strong support to a special symmetry of the Bremsstrahlung function under the formal discrete {{{Z}}_2} symmetry L → -1 - L. In this context, it is the counterpart of the reciprocity invariance discovered in the past in the spectrum of various gauge invariant composite operators. The {{{Z}}_2} symmetry has remarkable consequences in the scaling limit where L is taken to be large with fixed ratio to the 't Hooft coupling. This limit organizes in inverse powers of the coupling and resembles the semiclassical expansion of the dual string theory which is indeed known to capture the leading classical term. We show that the various higher-order contributions to the Bremsstrahlung function obey several constraints and, in particular, the next-to-leading term, formally associated with the string one-loop correction, is completely determined by the classical contribution. The large L limit at strong coupling is also discussed.

  11. Angular distribution of scattered electrons associated with collimated bremsstrahlung and the tagging technique

    NASA Astrophysics Data System (ADS)

    Maximon, L. C.; Ahrens, J.; Dugger, M.

    2009-05-01

    We investigate the angular correlation between a bremsstrahlung photon and its corresponding post-bremsstrahlung electron within the context of a magnetic tagging spectrometer with the aim of improving the instrument's efficiency. Our results are given in terms of angular distributions of the post-bremsstrahlung electron associated with photons that pass through a circular collimator centered in the forward direction. We start from the fully differential Bethe-Heitler (first Born approximation) cross-section, including the Molière screening correction, which is then integrated over the photon azimuthal angle and over the photon polar angle defined by the collimator. These integrations are performed analytically, making no high energy or small angle approximations. To obtain numerical values from the results of these integrations a multiprecision program is used to avoid severe problems of cancellations, especially at high energies (above 1 GeV). Making use of the angular correlation between the electron and the photon, we show that it is possible to increase the usable photon flux if we avoid the detection of electrons with large angles that have no photon partner passing the collimator. This can be accomplished by limiting the size of the electron detectors in the plane perpendicular to the bend plane.

  12. Optimal design of anger camera for bremsstrahlung imaging: monte carlo evaluation.

    PubMed

    Walrand, Stephan; Hesse, Michel; Wojcik, Randy; Lhommel, Renaud; Jamar, François

    2014-01-01

    A conventional Anger camera is not adapted to bremsstrahlung imaging and, as a result, even using a reduced energy acquisition window, geometric x-rays represent <15% of the recorded events. This increases noise, limits the contrast, and reduces the quantification accuracy. Monte Carlo (MC) simulations of energy spectra showed that a camera based on a 30-mm-thick BGO crystal and equipped with a high energy pinhole collimator is well-adapted to bremsstrahlung imaging. The total scatter contamination is reduced by a factor 10 versus a conventional NaI camera equipped with a high energy parallel hole collimator enabling acquisition using an extended energy window ranging from 50 to 350 keV. By using the recorded event energy in the reconstruction method, shorter acquisition time and reduced orbit range will be usable allowing the design of a simplified mobile gantry. This is more convenient for use in a busy catheterization room. After injecting a safe activity, a fast single photon emission computed tomography could be performed without moving the catheter tip in order to assess the liver dosimetry and estimate the additional safe activity that could still be injected. Further long running time MC simulations of realistic acquisitions will allow assessing the quantification capability of such system. Simultaneously, a dedicated bremsstrahlung prototype camera reusing PMT-BGO blocks coming from a retired PET system is currently under design for further evaluation. PMID:24982849

  13. Optimal Design of Anger Camera for Bremsstrahlung Imaging: Monte Carlo Evaluation

    PubMed Central

    Walrand, Stephan; Hesse, Michel; Wojcik, Randy; Lhommel, Renaud; Jamar, François

    2014-01-01

    A conventional Anger camera is not adapted to bremsstrahlung imaging and, as a result, even using a reduced energy acquisition window, geometric x-rays represent <15% of the recorded events. This increases noise, limits the contrast, and reduces the quantification accuracy. Monte Carlo (MC) simulations of energy spectra showed that a camera based on a 30-mm-thick BGO crystal and equipped with a high energy pinhole collimator is well-adapted to bremsstrahlung imaging. The total scatter contamination is reduced by a factor 10 versus a conventional NaI camera equipped with a high energy parallel hole collimator enabling acquisition using an extended energy window ranging from 50 to 350 keV. By using the recorded event energy in the reconstruction method, shorter acquisition time and reduced orbit range will be usable allowing the design of a simplified mobile gantry. This is more convenient for use in a busy catheterization room. After injecting a safe activity, a fast single photon emission computed tomography could be performed without moving the catheter tip in order to assess the liver dosimetry and estimate the additional safe activity that could still be injected. Further long running time MC simulations of realistic acquisitions will allow assessing the quantification capability of such system. Simultaneously, a dedicated bremsstrahlung prototype camera reusing PMT–BGO blocks coming from a retired PET system is currently under design for further evaluation. PMID:24982849

  14. Efficiency improvements of x-ray simulations in EGSnrc user-codes using bremsstrahlung cross-section enhancement (BCSE)

    SciTech Connect

    Ali, E. S. M.; Rogers, D. W. O.

    2007-06-15

    This paper presents the implementation of the bremsstrahlung cross-section enhancement (BCSE) variance-reduction technique into the EGSnrc/BEAMnrc system. BCSE makes the simulation of x-ray production from bremsstrahlung targets more efficient; it does so by artificially making the rare event of bremsstrahlung emission more abundant, which increases the number of statistically-independent photons that contribute to reducing the variance of the quantity of interest without increasing the CPU time appreciably. BCSE does not perturb the charged-particle transport in EGSnrc and it is made compatible with all other variance-reduction techniques already used in EGSnrc and BEAMnrc, including range rejection, uniform bremsstrahlung splitting, and directional bremsstrahlung splitting. When optimally combining BCSE with splitting to simulate typical situations of interest in medical physics research and in clinical practice, efficiencies can be up to five orders of magnitude larger than those obtained with analog simulations, and up to a full order of magnitude larger than those obtained with optimized splitting alone (which is the state-of-the-art of the EGSnrc/BEAMnrc system before this study was carried out). This study recommends that BCSE be combined with the existing splitting techniques for all EGSnrc/BEAMnrc simulations that involve bremsstrahlung targets, both in the kilovoltage and megavoltage range. Optimum cross-section enhancement factors for typical situations in diagnostic x-ray imaging and in radiotherapy are recommended, along with an easy algorithm for simulation optimization.

  15. Investigation of Coulombic bremsstrahlung spectra of metallic targets for the photon energy region of 1-100keV.

    PubMed

    Singh, Amrit; Dhaliwal, A S

    2016-09-01

    In the present paper, the formation of bremsstrahlung spectra by ordinary bremsstrahlung (OB) and polarization bremsstrahlung (PB) in metallic targets by (35)S beta particles has been investigated in the photon energy region of 1-100keV. From the experimental measurements and the theoretical results obtained from Elwert corrected (non-relativistic) Bethe Heitler (EBH) theory, modified Elwert factor (relativistic) (FmodBH) theories for OB and Avdonina and Pratt (FmodBH+PB) theory for total bremsstrahlung (BS) having the contribution of PB into OB, it has been found that the contribution of PB into BS in a target is limited to a low energy region only and also varies with the atomic number of target material. The FmodBH+PB theory is in agreement with the experimental results in low energy regions of the target, whereas at high energy region FmodBH is found to give better agreement. Further, the present experimental results indicate that the screening effects in the Coulombic bremsstrahlung process cannot be neglected in the high energy region, and the multiple scattering and secondary electron emissions effects in thick target are required to be taken into account in describing the bremsstrahlung process. PMID:27400163

  16. Proceedings of clinical SPECT (single photon emission computed tomography) symposium

    SciTech Connect

    Not Available

    1986-09-01

    It has been five years since the last in-depth American College of Nuclear Physicians/Society of Nuclear Medicine Symposium on the subject of single photon emission computed tomography (SPECT) was held. Because this subject was nominated as the single most desired topic we have selected SPECT imaging as the basis for this year's program. The objectives of this symposium are to survey the progress of SPECT clinical applications that have taken place over the last five years and to provide practical and timely guidelines to users of SPECT so that this exciting imaging modality can be fully integrated into the evaluation of pathologic processes. The first half was devoted to a consideration of technical factors important in SPECT acquisition and the second half was devoted to those organ systems about which sufficient clinical SPECT imaging data are available. With respect to the technical aspect of the program we have selected the key areas which demand awareness and attention in order to make SPECT operational in clinical practice. These include selection of equipment, details of uniformity correction, utilization of phantoms for equipment acceptance and quality assurance, the major aspect of algorithms, an understanding of filtered back projection and appropriate choice of filters and an awareness of the most commonly generated artifacts and how to recognize them. With respect to the acquisition and interpretation of organ images, the faculty will present information on the major aspects of hepatic, brain, cardiac, skeletal, and immunologic imaging techniques. Individual papers are processed separately for the data base. (TEM)

  17. SPECT/CT Fusion in the Diagnosis of Hyperparathyroidism

    PubMed Central

    Monzen, Yoshio; Tamura, Akihisa; Okazaki, Hajime; Kurose, Taichi; Kobayashi, Masayuki; Kuraoka, Masatsugu

    2015-01-01

    Objective(s): In this study, we aimed to analyze the relationship between the diagnostic ability of fused single photon emission computed tomography/ computed tomography (SPECT/CT) images in localization of parathyroid lesions and the size of adenomas or hyperplastic glands. Methods: Five patients with primary hyperparathyroidism (PHPT) and 4 patients with secondary hyperparathyroidism (SHPT) were imaged 15 and 120 minutes after the intravenous injection of technetium99m-methoxyisobutylisonitrile (99mTc-MIBI). All patients underwent surgery and 5 parathyroid adenomas and 10 hyperplastic glands were detected. Pathologic findings were correlated with imaging results. Results: The SPECT/CT fusion images were able to detect all parathyroid adenomas even with the greatest axial diameter of 0.6 cm. Planar scintigraphy and SPECT imaging could not detect parathyroid adenomas with an axial diameter of 1.0 to 1.2 cm. Four out of 10 (40%) hyperplastic parathyroid glands were diagnosed, using planar and SPECT imaging and 5 out of 10 (50%) hyperplastic parathyroid glands were localized, using SPECT/CT fusion images. Conclusion: SPECT/CT fusion imaging is a more useful tool for localization of parathyroid lesions, particularly parathyroid adenomas, in comparison with planar and or SPECT imaging.

  18. Detection models for freehand SPECT reconstruction

    NASA Astrophysics Data System (ADS)

    Hartl, Alexander; Shakir, Dzhoshkun I.; Lasser, Tobias; Ziegler, Sibylle I.; Navab, Nassir

    2015-02-01

    Nuclear imaging modalities are commonly used tools in today’s diagnostics and therapy planning. However for interventional use they suffer from drawbacks which limit their application. Freehand SPECT was developed to provide 3D functional imaging during interventions. It combines a nuclear detector with an optical tracking system to obtain its position and orientation in space and synchronizes this with the detector readings. This information can be used to compute a 3D tomographic reconstruction of an activity distribution of a nuclear tracer. As there is no fixed geometry, the system matrix has to be computed on the fly. This is done with models of the detection process for completely arbitrary freehand acquisitions. The accuracy of the reconstructions is highly dependent on the used models of the detection process. Different models of the detection process were developed and evaluated in this work, in particular two analytical models as well as lookup tables generated from either real measurements or Monte Carlo simulations. We showed that it is possible to perform acceptable reconstructions with a simple but efficient analytical model. The use of lookup tables to generate the system matrix in Freehand SPECT is a fast solution with good accuracy.

  19. Advances in SPECT and PET Hardware.

    PubMed

    Slomka, Piotr J; Pan, Tinsu; Berman, Daniel S; Germano, Guido

    2015-01-01

    There have been significant recent advances in single photon emission computed tomography (SPECT) and positron emission tomography (PET) hardware. Novel collimator designs, such as multi-pinhole and locally focusing collimators arranged in geometries that are optimized for cardiac imaging have been implemented to reduce imaging time and radiation dose. These new collimators have been coupled with solid state photon detectors to further improve image quality and reduce scanner size. The new SPECT scanners demonstrate up to a 7-fold increase in photon sensitivity and up to 2 times improvement in image resolution. Although PET scanners are used primarily for oncological imaging, cardiac imaging can benefit from the improved PET sensitivity of 3D systems without inter-plane septa and implementation of the time-of-flight reconstruction. Additionally, resolution recovery techniques are now implemented by all major PET vendors. These new methods improve image contrast, image resolution, and reduce image noise. Simultaneous PET/magnetic resonance (MR) hybrid systems have been developed. Solid state detectors with avalanche photodiodes or digital silicon photomultipliers have also been utilized in PET. These new detectors allow improved image resolution, higher count rate, as well as a reduced sensitivity to electromagnetic MR fields. PMID:25721706

  20. Detection models for freehand SPECT reconstruction.

    PubMed

    Hartl, Alexander; Shakir, Dzhoshkun I; Lasser, Tobias; Ziegler, Sibylle I; Navab, Nassir

    2015-02-01

    Nuclear imaging modalities are commonly used tools in today's diagnostics and therapy planning. However for interventional use they suffer from drawbacks which limit their application. Freehand SPECT was developed to provide 3D functional imaging during interventions. It combines a nuclear detector with an optical tracking system to obtain its position and orientation in space and synchronizes this with the detector readings. This information can be used to compute a 3D tomographic reconstruction of an activity distribution of a nuclear tracer. As there is no fixed geometry, the system matrix has to be computed on the fly. This is done with models of the detection process for completely arbitrary freehand acquisitions. The accuracy of the reconstructions is highly dependent on the used models of the detection process. Different models of the detection process were developed and evaluated in this work, in particular two analytical models as well as lookup tables generated from either real measurements or Monte Carlo simulations. We showed that it is possible to perform acceptable reconstructions with a simple but efficient analytical model. The use of lookup tables to generate the system matrix in Freehand SPECT is a fast solution with good accuracy. PMID:25585618

  1. Bone SPECT/CT of Femoral Head Subchondral Insufficiency Fracture.

    PubMed

    Motomura, Goro; Yamamoto, Takuaki; Karasuyama, Kazuyuki; Iwamoto, Yukihide

    2015-09-01

    Subchondral insufficiency fracture of the femoral head may be confused with osteonecrosis, mainly because of radiological overlap. SPECT/CT with Tc-99 m hydroxymethylene diphosphonate images in 7 patients with subchondral insufficiency fracture were retrospectively reviewed and compared with those from 11 patients with symptomatic early osteonecrosis. In all of the hips with subchondral insufficiency fracture, SPECT/CT showed increased uptake at the subchondral lesions of the femoral head. On the other hand, in all of the hips with osteonecrosis, absence of uptake was confirmed at the subchondral lesions. SPECT/CT may assist in differentiating subchondral insufficiency fracture from osteonecrosis. PMID:26164176

  2. Fabrication of the pinhole aperture for AdaptiSPECT

    PubMed Central

    Kovalsky, Stephen; Kupinski, Matthew A.; Barrett, Harrison H.; Furenlid, Lars R.

    2015-01-01

    AdaptiSPECT is a pre-clinical pinhole SPECT imaging system under final construction at the Center for Gamma-Ray Imaging. The system is designed to be able to autonomously change its imaging configuration. The system comprises 16 detectors mounted on translational stages to move radially away and towards the center of the field-of-view. The system also possesses an adaptive pinhole aperture with multiple collimator diameters and pinhole sizes, as well as the possibility to switch between multiplexed and non-multiplexed imaging configurations. In this paper, we describe the fabrication of the AdaptiSPECT pinhole aperture and its controllers. PMID:26146443

  3. Design and development of MR-compatible SPECT systems for simultaneous SPECT-MR imaging of small animals

    NASA Astrophysics Data System (ADS)

    Tsui, Benjamin M. W.; Hugg, James W.; Xu, Jingyan; Chen, Si; Meier, Dirk; Edelstein, William; El-Sharkawy, Abdel; Wagenaar, Douglas J.; Patt, Bradley E.

    2011-03-01

    We describe a continuing design and development of MR-compatible SPECT systems for simultaneous SPECT-MR imaging of small animals. A first generation prototype SPECT system was designed and constructed to fit inside a MRI system with a gradient bore inner diameter of 12 cm. It consists of 3 angularly offset rings of 8 detectors (1"x1", 16x16 pixels MR-compatible solid-state CZT). A matching 24-pinhole collimator sleeve, made of a tungsten-compound, provides projections from a common FOV of ~25 mm. A birdcage RF coil for MRI data acquisition surrounds the collimator. The SPECT system was tested inside a clinical 3T MRI system. Minimal interference was observed on the simultaneously acquired SPECT and MR images. We developed a sparse-view image reconstruction method based on accurate modeling of the point response function (PRF) of each of the 24 pinholes to provide artifact-free SPECT images. The stationary SPECT system provides relatively low resolution of 3-5 mm but high geometric efficiency of 0.5- 1.2% for fast dynamic acquisition, demonstrated in a SPECT renal kinetics study using Tc-99m DTPA. Based on these results, a second generation prototype MR-compatible SPECT system with an outer diameter of 20 cm that fits inside a mid-sized preclinical MRI system is being developed. It consists of 5 rings of 19 CZT detectors. The larger ring diameter allows the use of optimized multi-pinhole collimator designs, such as high system resolution up to ~1 mm, high geometric efficiency, or lower system resolution without collimator rotation. The anticipated performance of the new system is supported by simulation data.

  4. FastSPECT II: A Second-Generation High-Resolution Dynamic SPECT Imager

    PubMed Central

    Furenlid, Lars R.; Wilson, Donald W.; Chen, Yi-chun; Kim, Hyunki; Pietraski, Philip J.; Crawford, Michael J.; Barrett, Harrison H.

    2010-01-01

    FastSPECT II is a recently commissioned 16-camera small-animal SPECT imager built with modular scintillation cameras and list-mode data-acquisition electronics. The instrument is housed in a lead-shielded enclosure and has exchangeable aperture assemblies and adjustable camera positions for selection of magnification, pinhole size, and field of view. The calibration of individual cameras and measurement of an overall system imaging matrix (1 mm3 voxels) are supported via a five-axis motion-control system. Details of the system integration and results of characterization and performance measurements are presented along with first tomographic images. The dynamic imaging capabilities of the instrument are explored and discussed. PMID:20877439

  5. Cardiac dedicated ultrafast SPECT cameras: new designs and clinical implications.

    PubMed

    Garcia, Ernest V; Faber, Tracy L; Esteves, Fabio P

    2011-02-01

    Myocardial perfusion imaging (MPI) using nuclear cardiology techniques has been widely applied in clinical practice because of its well-documented value in the diagnosis and prognosis of coronary artery disease. Industry has developed innovative designs for dedicated cardiac SPECT cameras that constrain the entire detector area to imaging just the heart. New software that recovers image resolution and limits image noise has also been implemented. These SPECT innovations are resulting in shortened study times or reduced radiation doses to patients, promoting easier scheduling, higher patient satisfaction, and, importantly, higher image quality. This article describes these cardiocentric SPECT software and hardware innovations, which provide a strong foundation for the continued success of myocardial perfusion SPECT. PMID:21233190

  6. Performance evaluation of advanced industrial SPECT system with diverging collimator.

    PubMed

    Park, Jang Guen; Jung, Sung-Hee; Kim, Jong Bum; Moon, Jinho; Yeom, Yeon Soo; Kim, Chan Hyeong

    2014-12-01

    An advanced industrial SPECT system with 12-fold-array diverging collimator was developed for flow visualization in industrial reactors and was discussed in the previous study. The present paper describes performance evaluation of the SPECT system under both static- and dynamic- flow conditions. Under static conditions, the movement of radiotracer inside the test reactor was compared with that of color tracer (blue ink) captured with a high-speed camera. The comparison of the reconstructed images obtained with the radiotracer and the SPECT system showed fairly good agreement with video-frames of the color tracer obtained with the camera. Based on the results of the performance evaluation, it is concluded that the SPECT system is suitable for investigation and visualization of flows in industrial flow reactors. PMID:25169132

  7. Portal vein aneurysm demonstrated by blood pool SPECT.

    PubMed

    Fukui, H; Kashiwagi, T; Kimura, K; Goto, M; Takei, Y; Kasahara, A; Kawano, S; Fusamoto, H; Kozuka, T; Kamada, T

    1992-11-01

    Portal vein aneurysms are rare and are occasionally suggested by ultrasound and usually confirmed by invasive angiography. Such a case was diagnosed by scintigraphic studies, most importantly blood pool SPECT, which clearly separates it from hepatic cysts. PMID:1424375

  8. Cervical SPECT Camera for Parathyroid Imaging

    SciTech Connect

    None, None

    2012-08-31

    Primary hyperparathyroidism characterized by one or more enlarged parathyroid glands has become one of the most common endocrine diseases in the world affecting about 1 per 1000 in the United States. Standard treatment is highly invasive exploratory neck surgery called Parathyroidectomy. The surgery has a notable mortality rate because of the close proximity to vital structures. The move to minimally invasive parathyroidectomy is hampered by the lack of high resolution pre-surgical imaging techniques that can accurately localize the parathyroid with respect to surrounding structures. We propose to develop a dedicated ultra-high resolution (~ 1 mm) and high sensitivity (10x conventional camera) cervical scintigraphic imaging device. It will be based on a multiple pinhole-camera SPECT system comprising a novel solid state CZT detector that offers the required performance. The overall system will be configured to fit around the neck and comfortably image a patient.

  9. Iterative restoration of SPECT projection images

    SciTech Connect

    Glick, S.J.; Xia, W.

    1997-04-01

    Photon attenuation and the limited nonstationary spatial resolution of the detector can reduce both qualitative and quantitative image quality in single photon emission computed tomography (SPECT). In this paper, a reconstruction approach is described which can compensate for both of these degradations. The approach involves processing the project data with Bellini`s method for attenuation compensation followed by an iterative deconvolution technique which uses the frequency distance principle (FDP) to model the distance-dependent camera blur. Modeling of the camera blur with the FDP allows an efficient implementation using fast Fourier transformation (FFT) methods. After processing of the project data, reconstruction is performed using filtered backprojections. Simulation studies using two different brain phantoms show that this approach gives reconstructions with a favorable bias versus noise tradeoff, provides no visually undesirable noise artifacts, and requires a low computational load.

  10. Time evolution of endpoint energy of Bremsstrahlung spectra and ion production from an electron cyclotron resonance ion source

    SciTech Connect

    Tarvainen, Ollie; Ropponen, Tommi; Jones, Peter; Kalvas, Taneli

    2008-01-01

    Electron cyclotron resonance ion sources (ECRIS) are used to produce high charge state heavy ion beams for the use of nuclear and materials science, for instance. The most powerful ECR ion sources today are superconducting. One of the problems with superconducting ECR ion sources is the use of high radio frequency (RF) power which results in bremsstrahlung radiation adding an extra heat load to the cryostat. In order to understand the electron heating process and timescales in the ECR plasma, time evolution measurement of ECR bremsstrahlung was carried out. In the measurements JYFL 14 GHz ECRIS was operated in a pulsed mode and bremsstrahlung data from several hundred RF pulses was recorded. Time evolution of ion production was also studied and compared to one of the electron heating theories. To analyze the measurement data at C++ program was developed. Endpoint energies of the bremsstrahlung spectra as a function of axial magnetic field strength, pressure and RF power are presented and ion production timescales obtained from the measurements are compared to bremsstrahlung emission timescales and one of the stochastic heating theories.

  11. The Impact of Hot Electrons on X-ray Spectra: e-e Bremsstrahlung and κ Distributions

    NASA Astrophysics Data System (ADS)

    Smith, Randall K.; Cui, Xiaohong; Foster, Adam; Yuasa, Takayuki

    2016-06-01

    Shocks, turbulence, and winds all influence the electron velocity distribution in hot plasmas, exciting lower-energy electrons and generating a high-energy (typically power-law) tail. Sufficiently energetic electrons will emit via an electron-electron (e-e) bremsstrahlung, a process not previously included in the AtomDB. We have added this process and calculate the impact e-e bremsstrahlung has on the spectra from the post-shock regions of an accreting magnetic cataclysmic variable (CV). We find the contribution of e-e bremsstrahlung to the total spectra exceeds 10% at ~100 keV, with the total emissivity in the post-shock accretion stream differing by more than 10% at energies above 60 keV. More generally a Maxwellian with a power law tail, typically termed a κ distribution, can have significant effects on the line and continuum X-rays emitted. In addition to the e-e bremsstrahlung term, there will be effects due to the impact of the electrons on the charge state distribution and the collisional excitation rates. We use the ``Maxwellian decomposition'' approach as described in Hahn & Savin (2015) to generate the rate coefficients for a κ distributions based on the recently-released AtomDB v3.0 atomic database. These values are compared to exact calculations done for selected recombination and bremsstrahlung rates, and are also compared to results from the CHIANTI KAPPA package.

  12. Comparison of Techniques to Reduce Bremsstrahlung Background Radiation from Monoenergetic Photon Beams

    SciTech Connect

    Johnson, M; McNabb, D

    2006-06-29

    An important applied technology is a tunable mono-energetic photon source [1]. These sources are made of relativistic electron accelerators coupled to low-energy lasers, which produce high-energy, mono-energetic-rays. One challenge associated with systems such as this is a continuum of bremsstrahlung background created when an electron beam passes through an aperture of some sort and the electron bunch or its halo impinges on the aperture pictured in figure 1. For instance, in the current T-REX [1] design for the interaction point between the laser- and electron-beam, the electron-beam passes through the center of a mirror used to reflect the laser. There is a potential with this design that bremsstrahlung radiation may be produced at the edges of the mirror openings and contaminate the mono-energetic photon beam. Certain applications [2] may be sensitive to this contamination. To reduce the bremsstrahlung contaminate a collimator (thickness {approx}24in. (calculated from XCOM database [3]) to attenuate by a factor of 10{sup -3} the 112MeV photons expected in the T-REX demonstration [1]) is situated between the aperture and target. To maximize the brightness of the photon-beam, the collimator opening must be no less than the size of the photon-beam spot size expected to be about 1mm. This fixes the collimator opening. a priori the aperture size must be greater than the collimator opening and is a function distance between the aperture and collimator. In this paper we focus on two approaches to estimate the aperture size, given a collimator and a target whose sizes and distances from the aperture are given. In the next section we will discuss these approaches.

  13. Bremsstrahlung production of low mass dielectrons in relativistic heavy ion collisions

    SciTech Connect

    Pal, D.; Srivastava, D.K.

    1996-09-01

    The distribution of low mass dielectrons likely to be produced in relativistic heavy ion collisions due to bremsstrahlung processes in quark matter and hadronic matter is obtained. Effort is made to minimize uncertainty and restore Lorentz covariance as compared with past calculations performed in a similar vein. It is found that the excess of dielectrons in S+Au collisions at 200{ital A}GeV measured by the CERES Collaboration at the CERN Super Proton Synchrotron may have an important contribution from these processes at very low masses. {copyright}{ital 1996 The American Physical Society.}

  14. Photon emission asymmetry in the elementary process of bremsstrahlung from transversely polarized electrons

    SciTech Connect

    Mergl, E.; Prinz, H.; Schroeter, C.D.; Nakel, W. )

    1992-08-10

    By using an electron-phonon coincidence method the photon emission asymmetry in the elementary process of bremsstrahlung from transversely polarized electrons was measured for fixed directions of the outgoing electrons and coplanar geometry. For an electron beam of 300 keV incident on a gold target, emission asymmetries up to 35% were found. Even in the case of no deflection of the decelerated outgoing electrons a nonzero photon emission asymmetry was observed. The measurements are a proper test for theories going beyond the first Born approximation.

  15. Pion-proton bremsstrahlung calculation and the ``experimental'' magnetic moment of Δ++(1232)

    NASA Astrophysics Data System (ADS)

    Lin, Dahang; Liou, M. K.; Ding, Z. M.

    1991-11-01

    A bremsstrahlung amplitude in the special two-energy-two-angle (TETAS) approximation, which is relativistic, gauge invariant, and consistent with the soft-photon theorem, is derived for the pion-proton bremsstrahlung (π+pγ) process near the Δ++(1232) resonance. In order to take into account bremsstrahlung emission from an internal Δ++ line with both charge and the anomalous magnetic moment λΔ, we have applied a radiation decomposition identity to modify Low's standard prescription for constructing a soft-photon amplitude. This modified procedure is very general; it can be used to derive the TETAS amplitude for any bremsstrahlung process with resonance. The derived TETAS amplitude is applied to calculate all π+pγ cross sections which can be compared with the experimental data. Treating λΔ as a free parameter in these calculations, we extract the ``experimental'' magnetic moment of the Δ++, μΔ, from recent data. The extracted values of μΔ are (3.7-4.2)e/(2mp) from the University of California, Los Angeles data and (4.6-4.9)e/(2mp) from the Paul Scherrer Institute data. Here, mp is the proton mass. These values are smaller than the value 5.58e/(2mp), the ``bare'' magnetic moment predicted by the SU(6) model or the quark model, but they are close to the value 4.25e/(2mp) predicted by the modified SU(6) model of Beg and Pais and to the value (4.41-4.89)e/(2mp) predicted by the corrected bag-model of Brown, Rho, and Vento. Using the extracted μΔ as an input for calculating π+pγ cross sections, we show that the overall agreement between the theoretical predictions calculated with the extracted μΔ and the experimental measurements is excellent. This agreement demonstrates that the TETAS amplitude can be used to describe almost all the available π+pγ data. Finally, we also treat λΔ as a complex quantity, λΔ=λR+iλI, in order to estimate the contribution from the imaginary part λI. The best fit to the data gives λI~=0, independent of the choice

  16. Emerging Hawking-Like Radiation from Gravitational Bremsstrahlung Beyond the Planck Scale.

    PubMed

    Ciafaloni, Marcello; Colferai, Dimitri; Veneziano, Gabriele

    2015-10-23

    We argue that, as a consequence of the graviton's spin-2, its bremsstrahlung in trans-Planckian-energy (E≫M(P)) gravitational scattering at small deflection angle can be nicely expressed in terms of helicity-transformation phases and their transfer within the scattering process. The resulting spectrum exhibits deeply sub-Planckian characteristic energies of order M(P)(2)/E≪M(P) (reminiscent of Hawking radiation), a suppressed fragmentation region, and a reduced rapidity plateau, in broad agreement with recent classical estimates. PMID:26551096

  17. Emerging Hawking-Like Radiation from Gravitational Bremsstrahlung Beyond the Planck Scale

    NASA Astrophysics Data System (ADS)

    Ciafaloni, Marcello; Colferai, Dimitri; Veneziano, Gabriele

    2015-10-01

    We argue that, as a consequence of the graviton's spin-2, its bremsstrahlung in trans-Planckian-energy (E ≫MP ) gravitational scattering at small deflection angle can be nicely expressed in terms of helicity-transformation phases and their transfer within the scattering process. The resulting spectrum exhibits deeply sub-Planckian characteristic energies of order MP2/E ≪MP (reminiscent of Hawking radiation), a suppressed fragmentation region, and a reduced rapidity plateau, in broad agreement with recent classical estimates.

  18. Constructive interference in the spectrum of bremsstrahlung on two amorphous targets

    NASA Astrophysics Data System (ADS)

    Bondarenco, M. V.; Shul'ga, N. F.

    2014-12-01

    We investigate the interference pattern in the spectrum of nondipole bremsstrahlung on two amorphous foils. It contains a suppression at lowest photon energies, an enhancement in the neighboring region, and subsequent evanescent oscillations. The net effect of suppressions and enhancements proves to be zero. The location and the origin of the spectral features is explained. Predictions of the rigorous Molière averaging are compared with those of the Gaussian averaging with Coulomb contributions to the rms multiple scattering angle. Comparison with experimental data and with previous theoretical predictions is included.

  19. Angular distribution of the bremsstrahlung emission during lower-hybrid current drive on PLT

    SciTech Connect

    von Goeler, S.; Stevens, J.; Bernabei, S.; Bitter, M.; Chu, T.K.; Efthimion, P.; Fisch, N.; Hooke, W.; Hill, K.; Hosea, J.

    1985-06-01

    The bremsstrahlung emission from the PLT tokamak during lower-hybrid current drive has been measured as a function of angle between the magnetic field and the emission direction. The emission is peaked strongly in the forward direction, indicating a strong anisotropy of the electron-velocity distribution. The data demonstrate the existence of a nearly flat tail of the velocity distribution, which extends out to approximately 500 keV and which is interpreted as the plateau created by Landau damping of the lower-hybrid waves.

  20. Measurement of the correlation between electron spin and photon linear polarization in atomic-field bremsstrahlung.

    PubMed

    Tashenov, S; Bäck, T; Barday, R; Cederwall, B; Enders, J; Khaplanov, A; Poltoratska, Yu; Schässburger, K-U; Surzhykov, A

    2011-10-21

    Atomic-field bremsstrahlung has been studied with a longitudinally polarized electron beam. The correlation between the initial orientation of the electron spin and the angle of photon polarization has been measured at the photon high energy tip region. In the time reversal this corresponds to a so-far unobserved phenomenon of production of longitudinally polarized electrons by photoionization of unpolarized atoms with linearly polarized photons. The results confirm the fully relativistic calculations for radiative recombination and suggest a new method for electron beam polarimetry. PMID:22107514

  1. Effect of electron collisions on transport coefficients induced by the inverse bremsstrahlung absorption in plasmas

    SciTech Connect

    Bendib, A.; Tahraoui, A.; Bendib, K.; Mohammed El Hadj, K.; Hueller, S.

    2005-03-01

    The transport coefficients of fully ionized plasmas under the influence of a high-frequency electric field are derived solving numerically the electron Fokker-Planck equation using a perturbation method, parametrized as a function of the electron mean-free-path {lambda}{sub ei} compared to the spatial scales L. The isotropic and anisotropic contributions of the inverse bremsstrahlung heating are considered. Electron-electron collision terms are kept in the analysis, which allows us to consider with sufficient accuracy to describe plasmas with arbitrary atomic number Z. Practical numerical fits of the transport coefficients are proposed as functions of Z and the collisionality parameter {lambda}{sub ei}/L.

  2. Coincidence measurement of the fully differential cross section for atomic-field bremsstrahlung

    NASA Technical Reports Server (NTRS)

    Faulk, J. D.; Quarles, C. A.

    1974-01-01

    A coincidence measurement was made of the absolute cross section for electron-atomic-field bremsstrahlung, differential in photon energy, photon-emission angle, and electron scattering angle. The incident electron energy was 140 keV and the scattering materials were thin films of aluminum and gold. The data are compared to the theoretical calculations of Elwert and Haug and of Bethe and Heitler. Both theories give generally satisfactory agreement for aluminum. The Elwert-Haug theory is somewhat more accurate for gold.

  3. Ready for prime time? Dual tracer PET and SPECT imaging

    PubMed Central

    Fakhri, Georges El

    2012-01-01

    Dual isotope single photon emission computed tomography (SPECT) and dual tracer positron emission tomography (PET) imaging have great potential in clinical and molecular applications in the pediatric as well as the adult populations in many areas of brain, cardiac, and oncologic imaging as it allows the exploration of different physiological and molecular functions (e.g., perfusion, neurotransmission, metabolism, apoptosis, angiogenesis) under the same physiological and physical conditions. This is crucial when the physiological functions studied depend on each other (e.g., perfusion and metabolism) hence requiring simultaneous assessment under identical conditions, and can reduce greatly the quantitation errors associated with physical factors that can change between acquisitions (e.g., human subject or animal motion, change in the attenuation map as a function of time) as is detailed in this editorial. The clinical potential of simultaneous dual isotope SPECT, dual tracer PET and dual SPECT/PET imaging are explored and summarized. In this issue of AJNMMI (http://www.ajnmmi.us), Chapman et al. explore the feasibility of simultaneous and sequential SPECT/PET imaging and conclude that down-scatter and crosstalk from 511 keV photons preclude obtaining useful SPECT information in the presence of PET radiotracers. They report on an alternative strategy that consists of performing sequential SPECT and PET studies in hybrid microPET/SPECT/CT scanners, now widely available for molecular imaging. They validate their approach in a phantom consisting of a 96-well plate with variable 99mTc and 18F concentrations and illustrate the utility of such approaches in two sequential SPECT-PET/CT studies that include 99mTc-MAA/18F-NaF and 99mTc-Pentetate/18F-NaF. These approaches will need to be proven reproducible, accurate and robust to variations in the experimental conditions before they can be accepted by the molecular imaging community and be implemented in routine molecular

  4. Neutron-proton bremsstrahlung as a possible probe of high-momentum component in nucleon momentum distribution

    NASA Astrophysics Data System (ADS)

    Xue, Hui; Xu, Chang; Yong, Gao-Chan; Ren, Zhongzhou

    2016-04-01

    Neutron-proton bremsstrahlung in intermediate energy nucleus-nucleus collisions is proposed as a possible probe to study the high-momentum component in nucleon momentum distribution of finite nucleus. Based on the Boltzmann-Uehling-Uhlenbeck (BUU) transport model, the effects of high-momentum component on the production of bremsstrahlung photons in the reaction of 12C+12 C collisions at different incident beam energies are studied. It is found that the high-momentum component increases the high-energy bremsstrahlung photon production remarkably. Furthermore, the ratio of photon production at different incident beam energies is suggested as a potential observable to probe the high-momentum component in nucleon momentum distribution of finite nucleus.

  5. Short-course R-CHOP followed by 90Y-Ibritumomab tiuxetan in previously untreated high-risk elderly diffuse large B-cell lymphoma patients: 7-year long-term results

    PubMed Central

    Stefoni, V; Casadei, B; Bottelli, C; Gaidano, G; Ciochetto, C; Cabras, M G; Ansuinelli, M; Argnani, L; Broccoli, A; Gandolfi, L; Pellegrini, C; Zinzani, P L

    2016-01-01

    An update at 7 years was conceived for our multicenter phase II study in which 55 elderly high-risk untreated diffuse large B-cell lymphoma patients were treated with 90Y-ibritumomab tiuxetan after a short course of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R-CHOP) as long-term follow-up analyses of this combined therapeutic modality are lacking. The overall response rate to the entire regimen was 80%, including 73% (40/55) of complete response (CR) rate and 7% (4/55) of partial response rate. At the time of writing, 24/55 (43.6%) patients experienced a progression disease and 20 of 40 (50%) patients who obtained a CR are still alive in continuous CR. With a median follow-up of 7 years, the disease-free survival was 43.3% and the progression-free survival was 36.1%. The overall survival at 7.9 years was 38.9% (27 deaths mainly because of lymphoma). Two patients developed secondary hematological malignancies, an acute myeloid leukemia and a myelodysplastic syndrome, at 4 and 3 years from radioimmunotherapy, respectively. Our data confirm the feasibility, efficacy and safety of four cycles of R-CHOP followed by radioimmunotherapy consolidation even in the long term: this combination allows dispensing less chemotherapy in a frail group of patients without invalidating response quality and duration. PMID:27176801

  6. Comparison of two different types of LiF:Mg,Cu,P thermoluminescent dosimeters for detection of beta rays (beta-TLDs) from 90Sr/90Y, 85Kr and 147Pm sources.

    PubMed

    Grassi, Elisa; Sghedoni, Roberto; Piccagli, Vando; Fioroni, Federica; Borasi, Giovanni; Iori, Mauro

    2011-05-01

    Targeted radionuclide therapies in nuclear medicine departments increasingly depend on using unsealed beta radiation sources in the labeling of peptides and antibodies. Monitoring doses received by the fingers and hands during these procedures is best accomplished with TLD dosimeters that can be located at the fingertips. The present study examines the response of two TLD dosimeters (MCP-Ns and GR200A) to 90Sr/90Y, 85Kr, and 147Pm. The dosimeters were supplied by two different services, and all irradiations were performed at the PTB Institute in Germany. Each dosimetry service evaluated the dosimeters without knowledge that they had been purposefully irradiated. The accuracy and precision of the dosimeters were evaluated as a function of delivered dose, energy of beta particles and angular incidence. The results are compared to performance measures recommended by the IEC. Both dosimeter types displayed significant energy dependence. Angular dependence was moderate. Accuracy and precision as a function of dose (linearity) differed between the two systems, with the MCP-Ns being noticeably better than the GR200A. The superior precision makes the MCP-Ns much more useful for extremity dose measurements. The differences between these two dosimeter systems reinforce the need to evaluate a dosimeter carefully before using it in the daily work routine. PMID:21451322

  7. Short-course R-CHOP followed by (90)Y-Ibritumomab tiuxetan in previously untreated high-risk elderly diffuse large B-cell lymphoma patients: 7-year long-term results.

    PubMed

    Stefoni, V; Casadei, B; Bottelli, C; Gaidano, G; Ciochetto, C; Cabras, M G; Ansuinelli, M; Argnani, L; Broccoli, A; Gandolfi, L; Pellegrini, C; Zinzani, P L

    2016-01-01

    An update at 7 years was conceived for our multicenter phase II study in which 55 elderly high-risk untreated diffuse large B-cell lymphoma patients were treated with (90)Y-ibritumomab tiuxetan after a short course of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R-CHOP) as long-term follow-up analyses of this combined therapeutic modality are lacking. The overall response rate to the entire regimen was 80%, including 73% (40/55) of complete response (CR) rate and 7% (4/55) of partial response rate. At the time of writing, 24/55 (43.6%) patients experienced a progression disease and 20 of 40 (50%) patients who obtained a CR are still alive in continuous CR. With a median follow-up of 7 years, the disease-free survival was 43.3% and the progression-free survival was 36.1%. The overall survival at 7.9 years was 38.9% (27 deaths mainly because of lymphoma). Two patients developed secondary hematological malignancies, an acute myeloid leukemia and a myelodysplastic syndrome, at 4 and 3 years from radioimmunotherapy, respectively. Our data confirm the feasibility, efficacy and safety of four cycles of R-CHOP followed by radioimmunotherapy consolidation even in the long term: this combination allows dispensing less chemotherapy in a frail group of patients without invalidating response quality and duration. PMID:27176801

  8. Comparison of transmission acquisition approaches for SPECT nonuniform attenuation compensation

    SciTech Connect

    Gilland, D.R.; Jaszczak, R.J.; Turkington, T.G.; Coleman, R.E.

    1998-06-01

    This study compared two approaches for acquiring transmission computed tomography (TCT) data for SPECT nonuniform attenuation compensation. One approach, which has been implemented in commercial SPECT systems, acquires the TCT and SPECT data simultaneously using a scanning transmission line source, dual head SPECT system and parallel beam collimation (PB-sim). The other approach acquires the TCT and SPECT data sequentially using long focus, off-set fan beam collimation with a non-scanning line source and a triple head system (FB-seq). The two systems were compared based on: (a) the noise level of the TCT projection data, (b) the spatial resolution of the TCT projection data, and (c) the quality of reconstructed TCT and SPECT images of a thorax phantom. For the thorax phantom data a fast TCT scan (2 min.) was used and total scan time (TCT and SPECT) was the same for the two systems. The results from the TCT noise measurements showed that for the source activities used here (400 mCi for PB-sim, 56 mCi for FB-seq), PB-sim had higher in the heart and liver regions. The measured TCT spatial resolution for the two systems was comparable in the axial direction but was superior with FB-seq in the transaxial direction. The resolution difference was apparent in the reconstructed TCT images. These results suggest that the FB-seq system offers a viable approach for TCT acquisition and one that compares favorably with current commercial approaches based on TCT noise, resolution and reconstructed image quality.

  9. Simultaneous investigation of parent electrons and bremsstrahlung X rays by rocket-borne detectors

    NASA Technical Reports Server (NTRS)

    Vij, K. K.; Venkatesan, D.; Sheldon, W. R.; Kern, J. W.; Benbrook, J. R.; Whalen, B. A.

    1975-01-01

    Simultaneous measurements of the energy spectrum of precipitating electrons and the resulting bremsstrahlung X-ray spectrum were carried out during an auroral event on March 3, 1971, at the Churchill Research Range, Manitoba, Canada. The electron data were obtained with detectors on a Black Brant VB sounding rocket (275-km apogee), while the X-ray flux was measured by an instrument package that was boosted to 60 km on an Arcas rocket. The X-ray package was deployed on a parachute at apogee to provide a slow descent through the atmosphere. Thick-target bremsstrahlung theory is used to calculate the X-ray flux produced by the incident electrons, and a Monte Carlo method is used to predict the X-ray spectrum at various altitudes appropriate for comparison with the measured X-ray data. Satisfactory agreement between theory and experiment is obtained, and the value of the constant in the thick target theory has been estimated to be about 0.00002.

  10. Characterizing Hot Electron Generation and Transport via Bremsstrahlung Emission on the High Intensity OMEGA EP Laser

    NASA Astrophysics Data System (ADS)

    Peebles, J.; McGuffey, C.; Krauland, C.; Sorokovikova, A.; Qiao, B.; Krasheninnikov, S.; Beg, F. N.; Wei, M. S.; Stephens, R. B.; Chen, C. D.; Westover, B.; McLean, H. S.

    2014-10-01

    The investigation of high intensity laser generated fast electron beams is important for a number of High Energy Density Science applications, which include proton sources and fast ignition among others. A series of experimental campaigns performed using the kilojoule, 10-ps OMEGA EP laser closely examined the impact of a preformed plasma on laser plasma interaction and electron generation. Here we present the analysis of the measured bremsstrahlung x-ray radiation and the inferred results on fast electron characteristics. Simulations, performed with the Monte-Carlo code package ITS 3.0, generate the x-ray response of the target to an injected electron beam with a given temperature, energy and divergence angle. The simulated x-rays are then compared to those collected by the bremsstrahlung spectrometers, which allows us to characterize fast electrons created in the experiment. Preliminary results show a decrease in hot electron temperature with an increase in pre-pulse, which is further corroborated by magnetic electron and Cu-K α spectrometers. This work performed under the auspices of the US DOE under contracts DE-FOA-0000583 (FES, NNSA), DE-NA0002026 (NLUF) and DE-FC02-04ER54789 (FSC).

  11. Photoactivation of the p-nucleus 92Mo with bremsstrahlung at ELBE

    NASA Astrophysics Data System (ADS)

    Erhard, M.; Grosse, E.; Junghans, A. R.; Klug, J.; Nair, C.; Rusev, G.; Schilling, K. D.; Schwengner, R.; Wagner, A.

    2010-01-01

    In nuclear network calculations especially the p-nucleus 92Mo is frequently underproduced. Since experimental data of the photodisintegration of 92Mo so far do not exist, it was necessary to measure the reaction yields with the photoactivation method using the brems-strahlung facility ELBE at FZ Dresden-Rossendorf. Also the reaction 100Mo(γ,n) could be tested while irradiating Mo samples of natural composition. The photon fluence was measured with nuclear resonance fluorescence (NRF) of strong and well-known transitions in 11B. As a normalization standard the photoactivation reaction 197Au(γ,n) was used. For the 65 s half-life of 91mMo a fast pneumatic delivery was used. The photoactivation yields of the (γ,p) and (γ,n) reactions are compared to yield integrals of the bremsstrahlung spectral shape folded with the cross sections derived from Hauser-Feshbach nuclear model calculations using the TALYS program and cross sections from earlier experiments.

  12. Characterization of intense laser-produced fast electrons using hard x-rays via bremsstrahlung

    NASA Astrophysics Data System (ADS)

    Sawada, H.; Sentoku, Y.; Bass, A.; Griffin, B.; Pandit, R.; Beg, F.; Chen, H.; McLean, H.; Link, A. J.; Patel, P. K.; Ping, Y.

    2015-11-01

    Energy distribution of high-power, short-pulse laser produced fast electrons was experimentally and numerically studied using high-energy bremsstrahlung x-rays. The hard x-ray photons and escaping electrons from various metal foils, irradiated by the 50 TW Leopard laser at Nevada Terawatt Facility, were recorded with a differential filter stack spectrometer that is sensitive to photons produced by mainly 0.5-2 MeV electrons and an electron spectrometer measuring >2 MeV electrons. The experimental bremsstrahlung and the slope of the measured escaped electrons were compared with an analytic calculation using an input electron spectrum estimated with the ponderomotive scaling. The result shows that the electron spectrum entering a Cu foil could be continuous single slope with the slope temperature of ˜1.5 MeV in the detector range. The experiment and analytic calculation were then compared with a 2D particle-in-cell code, PICLS, including a newly developed radiation transport module. The simulation shows that a two-temperature electron distribution is generated at the laser interaction region, but only the hot component of the fast electrons flow into the target during the interaction because the low energy electron component is trapped by self-generated magnetic field in the preformed plasma. A significant amount of the photons less than 100 keV observed in the experiment could be attributed to the low energy electrons entering the foil a few picoseconds later after the gating field disappears.

  13. Analyzing power in pion-proton bremsstrahlung, and the. Delta. sup ++ (1232) magnetic moment

    SciTech Connect

    Bosshard, A.; Amsler, C.; Doebeli, M.; Doser, M.; Schaad, M.; Riedlberger, J.; Truoel, P. ); Bistirlich, J.A.; Crowe, K.M.; Ljungfelt, S.; Meyer, C.A. ); van den Brandt, B.; Konter, J.A.; Mango, S.; Renker, D. ); Loude, J.F.; Perroud, J.P. ); Haddock, R.P. ); Sober, D.I. )

    1991-10-01

    We report on a first measurement of the polarized-target asymmetry of the pion-proton bremsstrahlung cross section ({pi}{sup +}{ital p}{r arrow}{pi}{sup {minus}}{ital p}{gamma}). As in previous cross section measurements the pion energy (298 MeV) and the detector geometry for this experiment was chosen to optimize the sensitivity to the radiation from the magnetic dipole moment of the {Delta}{sup ++}(1232) resonance {mu}{sub {Delta}}. Comparison to a recent isobar model for pion-nucleon bremsstrahlung yields {mu}{sub {Delta}}=(1.62{plus minus}0.18){mu}{sub {ital p}}, where {mu}{sub {ital p}} is the proton magnetic moment. Since the asymmetry depends less than the cross section on the choice of the other input parameters for the model, their uncertainties affect this analysis by less than the experimental error. However the theory fails to represent both the cross section and the asymmetry data at the highest photon energies. Hence further improvements in the calculations are needed before the model dependence of the magnetic moment analysis can be fully assessed. The present result agrees with bag-model corrections to the SU(6) prediction {mu}{sub {Delta}}=2{mu}{sub {ital p}}. As a by-product, the analyzing power for elastic {pi}{sup +}{ital p} scattering at 415 MeV/{ital c} was also measured. This second result is in good agreement with phase shift calculations.

  14. Analysis of Fast Electron Energy Distribution by Measuring Hard X-ray Bremsstrahlung

    NASA Astrophysics Data System (ADS)

    Daykin, Tyler; Sawada, Hiroshi; Sentoku, Yasuhiko; Bass, Anthony; Griffin, Brandon; Pandit, Rishi; Beg, Farhat; Chen, Hui; McLean, Harry; Link, Anthony; Patel, Prav; Ping, Yuan

    2015-11-01

    Characterization of intense, short-pulse laser-produced fast electrons is important for fundamental understanding and applications. We carried out an experiment to characterize the fast electron energy distribution by measuring angular-dependent high-energy bremsstrahlung x-rays. A 100 μm thick metal foil (Al, Cu, and Ag) mounted on a plastic backing was irradiated by the 0.35 ps, 15 J Leopard Laser at the Nevada Terawatt Facility. The bremsstrahlung x-rays and the escaping electrons from the target were recorded using differential filter stack spectrometers at 22° and 45° off laser axis and a magnet-based electron spectrometer along the laser axis. The electron spectrum inferred from two different diagnostics had single slope temperature of ~ 1.5 MeV for the Cu foil. The results were compared to an analytic calculation and a 2-D Particle-in-cell code, PICLS. The analysis of the electron energy distribution and angular distribution will be presented. This work was supported by the UNR Office of the Provost and by DOE/OFES under Contract No. DE-SC0008827. This collaborative work was partially supported under the auspices of the US Department of Energy by Lawrence Livermore National Laboratory under Con.

  15. Initial studies of Bremsstrahlung energy deposition in small-bore superconducting undulator structures in linac environments

    SciTech Connect

    Cremer, T.; Tatchyn, R.

    1995-12-31

    One of the more promising technologies for developing minimal-length insertion devices for linac-driven, single-pass Free Electron Lasers (FELs) operating in the x-ray range is based on the use of superconducting (SC) materials. In recent FEL simulations, for example, a bifilar helical SC device with a 2 cm period and 1.8 T field was found to require a 30 m saturation length for operation at 1.5{Angstrom} on a 15 GeV linac, more than 40% shorter than an alternative hybrid/permanent magnet (hybrid/PM) undulator. AT the same time, however, SC technology is known to present characteristic difficulties for insertion device design, both in engineering detail and in operation. Perhaps the most critical problem, as observed, e.g., by Madey and co-workers in their initial FEL experiments, was the frequent quenching induced by scattered electrons upstream of their (bifilar) device. Postulating that this quenching was precipitated by directly-scattered or bremsstrahlung-induced particle energy deposited into the SC material or into material contiguous with it, the importance of numerical and experimental characterizations of this phenomenon for linac-based, user-facility SC undulator design becomes evident. In this paper we discuss selected prior experimental results and report on initial EGS4 code studies of scattered and bremsstrahlung induced particle energy deposition into SC structures with geometries comparable to a small-bore bifilar helical undulator.

  16. W/Z bremsstrahlung as the dominant annihilation channel for dark matter

    SciTech Connect

    Bell, Nicole F.; Jacques, Thomas D.; Dent, James B.; Weiler, Thomas J.

    2011-01-01

    Dark matter annihilation to leptons, {chi}{chi}{yields}ll, is necessarily accompanied by electroweak radiative corrections, in which a W or Z boson is radiated from a final-state particle. Given that the W and Z gauge bosons decay dominantly via hadronic channels, it is thus impossible to produce final-state leptons without accompanying protons, antiprotons, and gamma rays. Significantly, while many dark matter models feature a helicity-suppressed annihilation rate to fermions, radiating a massive gauge boson from a final-state fermion removes this helicity suppression, such that the branching ratios Br(l{nu}W), Br(l{sup +}l{sup -}Z), and Br({nu}{nu}Z) dominate over Br(ll). W/Z bremsstrahlung thus allows indirect detection of many weakly interacting massive particle models that would otherwise be helicity suppressed, or v{sup 2} suppressed. Antiprotons and even antideuterons become consequential final-state particles. This is an important result for future dark matter searches. We discuss the implications of W/Z bremsstrahlung for 'leptonic' dark matter models which aim to fit recent cosmic ray positron and antiproton data.

  17. Spin-orbit interaction in bremsstrahlung and its effect on the electron motion in a strong Coulomb field

    NASA Astrophysics Data System (ADS)

    Kovtun, Oleksiy; Tioukine, Valeri; Surzhykov, Andrey; Yerokhin, Vladimir A.; Cederwall, Bo; Tashenov, Stanislav

    2015-12-01

    Linear polarization of bremsstrahlung x rays produced in collisions of longitudinally polarized 2.1-MeV electrons with gold atoms was studied using the Compton scattering technique. We observed that the angle of x-ray polarization is strongly correlated with the incoming electron polarization. This correlation reveals the dominance of the spin-orbit interaction in bremsstrahlung and indicates a striking effect of the electron spin on the electron motion in a strong Coulomb field. The results confirm the validity of the theoretical predictions in a computationally challenging energy regime.

  18. Diagnosis of orbital cavernous hemangioma with Tc-99m RBC SPECT.

    PubMed

    Ki, W W; Shin, J W; Won, K S; Ryu, J S; Yang, S O; Lee, H K; Kim, Y J

    1997-08-01

    The authors report two cases of orbital cavernous hemangioma diagnosed by Tc-99m RBC SPECT. Tc-99m RBC SPECT showed a typical scintigraphic pattern commonly seen in hepatic hemangioma in which there is intense focally increased uptake on delayed SPECT images. Tc-99m RBC SPECT in orbital cavernous hemangioma may be as useful a diagnostic modality as in hepatic hemangioma. PMID:9262901

  19. Multimodality tomographic scintimammography with PET, PECI, and SPECT: initial evaluation

    NASA Astrophysics Data System (ADS)

    Krol, Andrzej; Feiglin, David H.; Thomas, Frank D.; Hellwig, Bradford J.; Gagne, George M.

    2002-04-01

    We compared tomographic scintimammography performed using single photon emission computed tomography (SPECT), positron emission coincidence imaging (PECI) and positron emission tomography (PET). A female thorax phantom was used. Activities of the myocardium, thorax and breasts were adjusted to emulate the count rate observed with patients. Hollow plastic spheres, imitating hot lesions (1.5-20ml), filled with radioactive saline were inserted in the center of each breast. Specific activities of internal organs were adjusted to emulate the count rate observed with patients. SPECT data were acquired with Tc-99m using gamma cameras with NaI(Tl) detectors. A modified FBP (CODE) reconstruction algorithm was used to render SPECT tomographic images. PECI (Siemens E.CAM with NaI(Tl)) and PET (GE Advance with BGO) data were acquired using F-18 FDG. Vendor supplied reconstruction algorithms were used. The reconstructed hot lesions contrast and resolution were investigated. Image quality obtained can be ranked as follows: (1) PET(BGO), (2) PECI(NaI), (3) SPECT(NaI) In conclusion, assuming comparable uptake values of Tc-99m-sestamibi and F-18 FDG, PET seems to be a superior methodology in visualization of breast lesion as compared to SPECT and PECI. All these tomographic methods appear to be promising adjunct to x-ray mammography in difficult to interpret cases.

  20. Performance Evaluation of a Bedside Cardiac SPECT System

    SciTech Connect

    M.T. Studenski, D.R. Gilland, J.G. Parker, B. Hammond, S. Majewski, A.G. Weisenberger, V. Popov

    2009-06-01

    This paper reports on the initial performance evaluation of a bedside cardiac PET/SPECT system. The system was designed to move within a hospital to image critically-ill patients, for example, those in intensive care unit (ICU) or emergency room settings, who cannot easily be transported to a conventional SPECT or PET facility. The system uses two compact (25 cm times 25 cm) detectors with pixilated NaI crystals and position sensitive PMTs. The performance is evaluated for both 140 keV (Tc-99m) and 511 keV (F-18) emitters with the system operating in single photon counting (SPECT) mode. The imaging performance metrics for both 140 keV and 511 keV included intrinsic energy resolution, spatial resolution (intrinsic, system, and reconstructed SPECT), detection sensitivity, count rate capability, and uniformity. Results demonstrated an intrinsic energy resolution of 31% at 140 keV and 23% at 511 keV, a planar intrinsic spatial resolution of 5.6 mm full width half-maximum (FWHM) at 140 keV and 6.3 mm FWHM at 511 keV, and a sensitivity of 4.15 countsmiddotmuCi-1 ldr s-1 at 140 keV and 0.67 counts ldr muCi-1 ldr s-1 at 511 keV. To further the study, a SPECT acquisition using a dynamic cardiac phantom was performed, and the resulting reconstructed images are presented.

  1. Recent developments and future prospects of SPECT myocardial perfusion imaging.

    PubMed

    Zaman, Maseeh Uz; Hashmi, Ibrahim; Fatima, Nosheen

    2010-10-01

    Myocardial perfusion SPECT imaging is the most commonly performed functional imaging for assessment of coronary artery disease. High diagnostic accuracy and incremental prognostic value are the major benefits while suboptimal spatial resolution and significant radiation exposure are the main limitations. Its ability to detect hemodynamic significance of lesions seen on multidetector CT angiogram (MDCTA) has paved the path for a successful marriage between anatomical and functional imaging modalities in the form of hybrid SPECT/MDCTA system. In recent years, there have been enormous efforts by industry and academia to develop new SPECT imaging systems with better sensitivity, resolution, compact design and new reconstruction algorithms with ability to improve image quality and resolution. Furthermore, expected arrival of Tc-99m-labeled deoxyglucose in next few years would further strengthen the role of SPECT in imaging hibernating myocardium. In view of these developments, it seems that SPECT would enjoy its pivotal role in spite of major threat to be replaced by fluorine-18-labeled positron emission tomography perfusion and glucose metabolism imaging agents. PMID:20652774

  2. Parallel-hole collimator concept for stationary SPECT imaging

    NASA Astrophysics Data System (ADS)

    Pato, Lara R. V.; Vandenberghe, Stefaan; Zedda, Tiziana; Van Holen, Roel

    2015-11-01

    Parallel-hole SPECT collimators have traditionally been manufactured by stacking sheets of lead foil or by casting. These techniques significantly restrict our options in terms of collimator geometry. However, recent developments in metal additive manufacturing are making novel collimator designs possible, giving rise to new opportunities in SPECT imaging. In this paper we propose an innovative type of collimator for stationary SPECT, using parallel-holes whose collimation direction depends on their axial position. Its main advantage compared to current stationary SPECT systems (which are based on pinholes) is that, using only axial bed translations, we can achieve complete angular sampling of an increased portion of the transaxial area of the collimator bore. This allows the system to be much more compact than current stationary SPECT systems that image objects of the same size. We describe three possible designs, for full-body, brain and small-animal imaging, respectively, and test their feasibility using simulations. The system modeling method is validated against realistic Monte Carlo simulations, and then used in the evaluation of the systems’ performances and reconstructions. The simulations show that the system is able to reconstruct objects occupying the predicted field of view (75% of the transaxial area of the bore) without sampling artifacts. In particular, we perform reconstructions from noisy projection data obtained for an activity and scanning time similar to standard protocols for the three applications, and the resulting images indicate the possibility of using the proposed systems in practice.

  3. Parallel-hole collimator concept for stationary SPECT imaging.

    PubMed

    Pato, Lara R V; Vandenberghe, Stefaan; Zedda, Tiziana; Van Holen, Roel

    2015-11-21

    Parallel-hole SPECT collimators have traditionally been manufactured by stacking sheets of lead foil or by casting. These techniques significantly restrict our options in terms of collimator geometry. However, recent developments in metal additive manufacturing are making novel collimator designs possible, giving rise to new opportunities in SPECT imaging. In this paper we propose an innovative type of collimator for stationary SPECT, using parallel-holes whose collimation direction depends on their axial position. Its main advantage compared to current stationary SPECT systems (which are based on pinholes) is that, using only axial bed translations, we can achieve complete angular sampling of an increased portion of the transaxial area of the collimator bore. This allows the system to be much more compact than current stationary SPECT systems that image objects of the same size. We describe three possible designs, for full-body, brain and small-animal imaging, respectively, and test their feasibility using simulations. The system modeling method is validated against realistic Monte Carlo simulations, and then used in the evaluation of the systems' performances and reconstructions. The simulations show that the system is able to reconstruct objects occupying the predicted field of view ([Formula: see text] of the transaxial area of the bore) without sampling artifacts. In particular, we perform reconstructions from noisy projection data obtained for an activity and scanning time similar to standard protocols for the three applications, and the resulting images indicate the possibility of using the proposed systems in practice. PMID:26528908

  4. A 3D image analysis tool for SPECT imaging

    NASA Astrophysics Data System (ADS)

    Kontos, Despina; Wang, Qiang; Megalooikonomou, Vasileios; Maurer, Alan H.; Knight, Linda C.; Kantor, Steve; Fisher, Robert S.; Simonian, Hrair P.; Parkman, Henry P.

    2005-04-01

    We have developed semi-automated and fully-automated tools for the analysis of 3D single-photon emission computed tomography (SPECT) images. The focus is on the efficient boundary delineation of complex 3D structures that enables accurate measurement of their structural and physiologic properties. We employ intensity based thresholding algorithms for interactive and semi-automated analysis. We also explore fuzzy-connectedness concepts for fully automating the segmentation process. We apply the proposed tools to SPECT image data capturing variation of gastric accommodation and emptying. These image analysis tools were developed within the framework of a noninvasive scintigraphic test to measure simultaneously both gastric emptying and gastric volume after ingestion of a solid or a liquid meal. The clinical focus of the particular analysis was to probe associations between gastric accommodation/emptying and functional dyspepsia. Employing the proposed tools, we outline effectively the complex three dimensional gastric boundaries shown in the 3D SPECT images. We also perform accurate volume calculations in order to quantitatively assess the gastric mass variation. This analysis was performed both with the semi-automated and fully-automated tools. The results were validated against manual segmentation performed by a human expert. We believe that the development of an automated segmentation tool for SPECT imaging of the gastric volume variability will allow for other new applications of SPECT imaging where there is a need to evaluate complex organ function or tumor masses.

  5. A SPECT imager with synthetic collimation

    PubMed Central

    Havelin, Ronan J.; Miller, Brian W.; Barrett, Harrison H.; Furenlid, Lars R.; Murphy, J M; Foley, Mark J.

    2015-01-01

    This work outlines the development of a multi-pinhole SPECT system designed to produce a synthetic-collimator image of a small field of view. The focused multi-pinhole collimator was constructed using rapid-prototyping and casting techniques. The collimator projects the field of view through forty-six pinholes when the detector is adjacent to the collimator. The detector is then moved further from the collimator to increase the magnification of the system. The amount of pinhole-projection overlap increases with the system magnification. There is no rotation in the system; a single tomographic angle is used in each system configuration. The maximum-likelihood expectation-maximization (MLEM) algorithm is implemented on graphics processing units to reconstruct the object in the field of view. Iterative reconstruction algorithms, such as MLEM, require an accurate model of the system response. For each system magnification, a sparsely-sampled system response is measured by translating a point source through a grid encompassing the field of view. The pinhole projections are individually identified and associated with their respective apertures. A 2D elliptical Gaussian model is applied to the pinhole projections on the detector. These coefficients are associated with the object-space location of the point source, and a finely-sampled system matrix is interpolated. Simulations with a hot-rod phantom demonstrate the efficacy of combining low-resolution non-multiplexed data with high-resolution multiplexed data to produce high-resolution reconstructions. PMID:26346410

  6. Secondary bremsstrahlung and the energy-conservation aspects of kerma in photon-irradiated media

    NASA Astrophysics Data System (ADS)

    Kumar, Sudhir; Nahum, Alan E.

    2016-02-01

    Kerma, collision kerma and absorbed dose in media irradiated by megavoltage photons are analysed with respect to energy conservation. The user-code DOSRZnrc was employed to compute absorbed dose D, kerma K and a special form of kerma, K ncpt, obtained by setting the charged-particle transport energy cut-off very high, thereby preventing the generation of ‘secondary bremsstrahlung’ along the charged-particle paths. The user-code FLURZnrc was employed to compute photon fluence, differential in energy, from which collision kerma, K col and K were derived. The ratios K/D, K ncpt/D and K col/D have thereby been determined over a very large volumes of water, aluminium and copper irradiated by broad, parallel beams of 0.1 to 25 MeV monoenergetic photons, and 6, 10 and 15 MV ‘clinical’ radiotherapy qualities. Concerning depth-dependence, the ‘area under the kerma, K, curve’ exceeded that under the dose curve, demonstrating that kerma does not conserve energy when computed over a large volume. This is due to the ‘double counting’ of the energy of the secondary bremsstrahlung photons, this energy being (implicitly) included in the kerma ‘liberated’ in the irradiated medium, at the same time as this secondary bremsstrahlung is included in the photon fluence which gives rise to kerma elsewhere in the medium. For 25 MeV photons this ‘violation’ amounts to 8.6%, 14.2% and 25.5% in large volumes of water, aluminium and copper respectively but only 0.6% for a ‘clinical’ 6 MV beam in water. By contrast, K col/D and K ncpt/D, also computed over very large phantoms of the same three media, for the same beam qualities, are equal to unity within (very low) statistical uncertainties, demonstrating that collision kerma and the special type of kerma, K ncpt, do conserve energy over a large volume. A comparison of photon fluence spectra for the 25 MeV beam at a depth of  ≈51 g cm-2 for both very high and very low charged-particle transport cut

  7. Quantitative Assessment of Myocardial Blood Flow with SPECT.

    PubMed

    Petretta, Mario; Storto, Giovanni; Pellegrino, Teresa; Bonaduce, Domenico; Cuocolo, Alberto

    2015-01-01

    The quantitative assessment of myocardial blood flow (MBF) and coronary flow reserve (CFR) may be useful for the functional evaluation of coronary artery disease, allowing judgment of its severity, tracking of disease progression, and evaluation of the anti-ischemic efficacy of therapeutic strategies. Quantitative estimates of myocardial perfusion and CFR can be derived from single-photon emission computed tomography (SPECT) myocardial perfusion images by use of equipment, tracers, and techniques that are available in most nuclear cardiology laboratories. However, this method underestimates CFR, particularly at high flow rates. The recent introduction of cardiac-dedicated gamma cameras with solid-state detectors provides very fast perfusion imaging with improved resolution, allowing fast acquisition of serial dynamic images during the first pass of a flow agent. This new technology holds great promise for MBF and CFR quantification with dynamic SPECT. Future studies will clarify the effectiveness of dynamic SPECT flow imaging. PMID:25560327

  8. Modeling dynamic PET-SPECT studies in the wavelet domain.

    PubMed

    Turkheimer, F E; Banati, R B; Visvikis, D; Aston, J A; Gunn, R N; Cunningham, V J

    2000-05-01

    This work develops a theoretical framework and corresponding algorithms for the modeling of dynamic PET-SPECT studies both in time and space. The problem of estimating the spatial dimension is solved by applying the wavelet transform to each scan of the dynamic sequence and then performing the kinetic modeling and statistical analysis in the wavelet domain. On reconstruction through the inverse wavelet transform, one obtains parametric images that are consistent estimates of the spatial patterns of the kinetic parameter of interest. The theoretical setup allows the use of linear techniques currently used in PET-SPECT for kinetic analysis. The method is applied to artificial and real data sets. The application to dynamic PET-SPECT studies was performed both for validation purposes, when the spatial patterns are known, and for illustration of the advantages offered by the technique in case of tracers with an unknown pattern of distribution. PMID:10826539

  9. Brain SPECT thallium using cadmium zinc telluride: a first experience.

    PubMed

    Farid, Karim; Queneau, Mathieu; Guernou, Mohamed; Lussato, David; Petras, Slavomir; Songy, Bernard

    2011-11-01

    A 70-year-old man underwent a thallium-201 brain SPECT in the work-up and characterization of a frontotemporal mass. SPECT images were performed on cadmium zinc telluride system during only 5 minutes and after the injection of only 2 mCi. Images demonstrated high thallium uptake in frontotemporal areas considered as a potential malignant tumor. Surgical removal confirmed the diagnosis of malignant glioblastoma. The thallium SPECT fast acquisition imaging on cadmium zinc telluride systems is feasible with reduced injected dose. This method allows a significantly decrease of patient radiation exposure without compromising the image quality. This initial experience needs to be confirmed and optimized in larger clinical studies. PMID:21975418

  10. The role of DAT-SPECT in movement disorders.

    PubMed

    Kägi, G; Bhatia, K P; Tolosa, E

    2010-01-01

    Dopamine transporter (DAT) imaging is a sensitive method to detect presynaptic dopamine neuronal dysfunction, which is a hallmark of neurodegenerative parkinsonism. DAT imaging can therefore assist the differentiation between conditions with and without presynaptic dopaminergic deficit. Diagnosis of Parkinson disease or tremor disorders can be achieved with high degrees of accuracy in cases with full expression of classical clinical features; however, diagnosis can be difficult, since there is a substantial clinical overlap especially in monosymptomatic tremor (dystonic tremor, essential tremor, Parkinson tremor). The use of DAT-SPECT can prove or excludes with high sensitivity nigrostriatal dysfunction in those cases and facilitates early and accurate diagnosis. Furthermore, a normal DAT-SPECT is helpful in supporting a diagnosis of drug-induced-, psychogenic- and vascular parkinsonism by excluding underlying true nigrostriatal dysfunction. This review addresses the value of DAT-SPECT and its impact on diagnostic accuracy in movement disorders presenting with tremor and/or parkinsonism. PMID:20019219

  11. Evaluation of S-values and dose distributions for {sup 90}Y, {sup 131}I, {sup 166}Ho, and {sup 188}Re in seven lobes of the rat liver

    SciTech Connect

    Xie Tianwu; Liu Qian; Zaidi, Habib

    2012-03-15

    Purpose: Rats have been widely used in radionuclide therapy research for the treatment of hepatocellular carcinoma (HCC). This has created the need to assess rat liver absorbed radiation dose. In most dose estimation studies, the rat liver is considered as a homogeneous integrated target organ with a tissue composition assumed to be similar to that of human liver tissue. However, the rat liver is composed of several lobes having different anatomical and chemical characteristics. To assess the overall impact on rat liver dose calculation, the authors use a new voxel-based rat model with identified suborgan regions of the liver. Methods: The liver in the original cryosectional color images was manually segmented into seven individual lobes and subsequently integrated into a voxel-based computational rat model. Photon and electron particle transport was simulated using the MCNPX Monte Carlo code to calculate absorbed fractions and S-values for {sup 90}Y, {sup 131}I, {sup 166}Ho, and {sup 188}Re for the seven liver lobes. The effect of chemical composition on organ-specific absorbed dose was investigated by changing the chemical composition of the voxel filling liver material. Radionuclide-specific absorbed doses at the voxel level were further assessed for a small spherical hepatic tumor. Results: The self-absorbed dose for different liver lobes varied depending on their respective masses. A maximum difference of 3.5% was observed for the liver self-absorbed fraction between rat and human tissues for photon energies below 100 keV. {sup 166}Ho and {sup 188}Re produce a uniformly distributed high dose in the tumor and relatively low absorbed dose for surrounding tissues. Conclusions: The authors evaluated rat liver radiation doses from various radionuclides used in HCC treatments using a realistic computational rat model. This work contributes to a better understanding of all aspects influencing radiation transport in organ-specific radiation dose evaluation for

  12. Relative Biologic Effects of Low-Dose-Rate {alpha}-Emitting {sup 227}Th-Rituximab and {beta}-Emitting {sup 90}Y-Tiuexetan-Ibritumomab Versus External Beam X-Radiation

    SciTech Connect

    Dahle, Jostein Bruland, Oyvind S.; Larsen, Roy H.

    2008-09-01

    Purpose: To determine the relative biologic effects (RBE) of {alpha}-particle radiation from {sup 227}Th-rituximab and of {beta}-radiation from {sup 90}Y-tiuexetan-ibritumomab (Zevalin) compared with external beam X-radiation in the Raji lymphoma xenograft model. Methods and Materials: Radioimmunoconjugates were administered intravenously in nude mice with Raji lymphoma xenografts at different levels of activity. Absorbed dose to tumor was estimated by separate biodistribution experiments for {sup 227}Th-rituximab and Zevalin. Tumor growth was measured two to three times per week after injection or X-radiation. Treatment-induced increase in growth delay to reach tumor volumes of 500 and 1,000 mm{sup 3}, respectively, was used as an end point. Results: The absorbed radiation dose-rate in tumor was slightly more than 0.1 Gy/d for the first week following injection of {sup 227}Th-rituximab, and thereafter gradually decreased to 0.03 Gy/d at 21 days after injection. For treatment with Zevalin the maximum dose-rate in tumor was achieved already 6 h after injection (0.2 Gy/d), and thereafter decreased to 0.01 Gy/d after 7 days. The relative biologic effect was between 2.5 and 7.2 for {sup 227}Th-rituximab and between 1 and 1.3 for Zevalin. Conclusions: Both at low doses and low-dose-rates, the {sup 227}Th-rituximab treatment was more effective per absorbed radiation dose unit than the two other treatments. The considerable effect at low doses suggests that the best way to administer low-dose-rates, {alpha}-emitting radioimmunoconjugates is via multiple injections.

  13. Z{sub eff} profile diagnostics using visible bremsstrahlung continuum for nonaxisymmetric plasmas with finite {beta} in large helical device

    SciTech Connect

    Zhou, H. Y.; Dong, C. F.; Morita, S.; Goto, M.

    2010-03-15

    An astigmatism-corrected Czerny-Turner-type visible spectrometer coupled with a charge-coupled device has been installed in large helical device (LHD) to measure visible bremsstrahlung continuum. A full vertical profile has been observed from the elliptical plasmas at horizontally elongated plasma cross section through a 44 fiber parallel array with vertical observation length of {approx}1 m. Line emissions can be easily eliminated by use of the visible spectrometer instead of an interference filter. A nonmonotonic bremsstrahlung emission profile, which is originated in the thick ergodic layer surrounding the main plasma, has been observed for normal discharges in all the magnetic configurations of LHD. After analyzing the detailed structure, the lower half of the vertical bremsstrahlung emission profile is found to be free of the strong edge bremsstrahlung emission in inwardly shifted magnetic configurations (R{sub ax{<=}}3.60 m). The nonmonotonic bremsstrahlung emission disappeared in extremely high-density discharges (n{sub e{>=}}10{sup 14} cm{sup -3}) because of the reduction of the plasma outside boundary. When the local emissivity is calculated using Abel inversion, the solution is very sensitive to the distortion of the magnetic surface structure. The influence of the magnetic surface distortion based on the finite {beta} effect is examined as error estimation in addition to unclear edge plasma boundary due to the presence of the ergodic layer. The result indicates that the determination of the normalized minor radius for each observation chord gives a larger influence on the Abel inversion rather than the determination of the chord length. When the observed chord-integrated bremsstrahlung intensity profile is flat, the resultant uncertainty seen in the bremsstrahlung emissivity profile becomes large, in particular, at the plasma center. The Z{sub eff} profile calculated with consideration of density and temperature profiles is verified in neutral

  14. Real-time SPECT and 2D ultrasound image registration.

    PubMed

    Bucki, Marek; Chassat, Fabrice; Galdames, Francisco; Asahi, Takeshi; Pizarro, Daniel; Lobo, Gabriel

    2007-01-01

    In this paper we present a technique for fully automatic, real-time 3D SPECT (Single Photon Emitting Computed Tomography) and 2D ultrasound image registration. We use this technique in the context of kidney lesion diagnosis. Our registration algorithm allows a physician to perform an ultrasound exam after a SPECT image has been acquired and see in real time the registration of both modalities. An automatic segmentation algorithm has been implemented in order to display in 3D the positions of the acquired US images with respect to the organs. PMID:18044572

  15. Determination of left ventricular mass through SPECT imaging

    NASA Astrophysics Data System (ADS)

    Zárate-Morales, A.; Rodríguez-Villafuerte, M.; Martínez-Rodríguez, F.; Arévila-Ceballos, N.

    1998-08-01

    An edge detection algorithm has been applied to estimate left ventricular (LV) mass from single photon emission computed tomography (SPECT) thallium-201 images. The algorithm was validated using SPECT images of a phantom. The algorithm was applied to 20 patient studies from the Hospital de Cardiologia, Centro Médico Nacional Siglo XXI. Left ventricular masses derived from the stress and redistribution studies were highly correlated (r=0.96). The average LV masses obtained were 162±37 g and 169±34 g in the redistribution and stress studies, respectively.

  16. Determination of left ventricular mass through SPECT imaging

    SciTech Connect

    Zarate-Morales, A.; Rodriguez-Villafuerte, M.; Martinez-Rodriguez, F.; Arevila-Ceballos, N.

    1998-08-28

    An edge detection algorithm has been applied to estimate left ventricular (LV) mass from single photon emission computed tomography (SPECT) thallium-201 images. The algorithm was validated using SPECT images of a phantom. The algorithm was applied to 20 patient studies from the Hospital de Cardiologia, Centro Medico Nacional Siglo XXI. Left ventricular masses derived from the stress and redistribution studies were highly correlated (r=0.96). The average LV masses obtained were 162{+-}37 g and 169{+-}34 g in the redistribution and stress studies, respectively.

  17. Bremsstrahlung-induced fission and spallation of the pre-actinide nucleus 181Ta

    NASA Astrophysics Data System (ADS)

    Deppman, A.; Karapetyan, G. S.; Guimarães, V.; Gonzales, C.; Balabekyan, A. R.; Demekhina, N. A.

    2015-02-01

    A study of photofission on 181Ta induced by bremsstrahlung with endpoint energies of 50 and 3500 MeV has been performed. The fission yields have been measured by using the induced-activity method in an off-line analysis. The total photofission yields for the tantalum target at 50 and 3500 MeV are found to be 5.4 ±1.1 μ b / equivalent quanta per second (eq.q) and 0.77 ±0.11 mb/eq.q, respectively, and the corresponding deduced fissilities are (0.23 ±0.05 )×10-3 and (2.9 ±0.5 )×10-3 . Mass- and charge-yield distributions were derived from the data. The results were compared with the simulated results from the crisp code for multimodal fission by the assuming symmetrical fission mode.

  18. Efficient far-infrared thermal bremsstrahlung radiation from a heterojunction bipolar transistor

    SciTech Connect

    Chung, Pei-Kang; Yen, Shun-Tung

    2015-08-28

    We investigate the far-infrared thermal radiation properties of a heterojunction bipolar transistor. The device conveniently provides a high electric field for electrons to heat the lattice and the electron gas in a background with ions embedded. Because of very high effective temperature of the electron gas in the collector, the electron-ion bremsstrahlung makes efficient the thermal radiation in the far-infrared region. The transistor can yield a radiation power of 0.1 mW with the spectral region between 2 and 75 THz and a power conversion efficiency of 6 × 10{sup −4}. Such output contains a power of 20 μW in the low-frequency part (2–20 THz) of the spectrum.

  19. Application of visible bremsstrahlung to Z(eff) measurement on the Experimental Advanced Superconducting Tokamak.

    PubMed

    Chen, Yingjie; Wu, Zhenwei; Gao, Wei; Ti, Ang; Zhang, Ling; Jie, Yinxian; Zhang, Jizong; Huang, Juan; Xu, Zong; Zhao, Junyu

    2015-02-01

    The multi-channel visible bremsstrahlung measurement system has been developed on Experimental Advanced Superconducting Tokamak (EAST). In addition to providing effective ion charge Zeff as a routine diagnostic, this diagnostic can also be used to estimate other parameters. With the assumption that Zeff can be seen as constant across the radius and does not change significantly during steady state discharges, central electron temperature, averaged electron density, electron density profile, and plasma current density profile have been obtained based on the scaling of Zeff with electron density and the relations between Zeff and these parameters. The estimated results are in good coincidence with measured values, providing an effective and convenient method to estimate other plasma parameters. PMID:25725844

  20. Relativistic theory for the elementary process of bremsstrahlung induced by heavy spin-zero nuclei

    NASA Astrophysics Data System (ADS)

    Jakubassa-Amundsen, D. H.

    2016-05-01

    Doubly and triply differential cross sections for the bremsstrahlung emission by high-energy spin-polarized electrons in the field of heavy bare nuclei are calculated within a fully relativistic partial-wave approach at collision energies between 1 and 30 MeV. Investigating 208Pb as a test case, it is shown that if the photons are emitted at backward angles, nuclear size effects may play an important role even below 10 MeV. Comparison is made with experimental data on the circular polarization correlations between incoming electron and emitted photon at a collision energy of 3.5 MeV. It is demonstrated that, independent of energy, the plane-wave Born approximation severely underestimates the cross section for heavy targets. Moreover, it gives at most a qualitative prescription of the polarization correlations, except possibly in the forward hemisphere.

  1. The effect of the {Delta} excitation on proton-proton bremsstrahlung

    SciTech Connect

    Lee, T.S.H.; Jong, F. de; Nakayama, K.

    1995-08-01

    The proton-proton bremsstrahlung is investigated with a coupled-channel model with {pi} and {Delta} degrees of freedom. The model is consistent with the NN scattering up to 1 GeV and the {gamma}N{Delta} vertex determined in the study of pion photoproduction on the nucleon. We find that the {Delta} excitation can significantly improve the agreement with the pp {yields} pp{gamma} data at E{sub L} = 280 MeV. The N{Delta} rescattering plays an important role in determining the angular distribution and analyzing powers. Predictions at E{sub L} = 550 and 800 MeV were made for the forthcoming experimental tests at COSY of Juelich. A paper describing our results was submitted for publication.

  2. Application of visible bremsstrahlung to Z{sub eff} measurement on the Experimental Advanced Superconducting Tokamak

    SciTech Connect

    Chen, Yingjie; Wu, Zhenwei; Gao, Wei; Ti, Ang; Zhang, Ling; Jie, Yinxian; Zhang, Jizong; Huang, Juan; Xu, Zong; Zhao, Junyu

    2015-02-15

    The multi-channel visible bremsstrahlung measurement system has been developed on Experimental Advanced Superconducting Tokamak (EAST). In addition to providing effective ion charge Z{sub eff} as a routine diagnostic, this diagnostic can also be used to estimate other parameters. With the assumption that Z{sub eff} can be seen as constant across the radius and does not change significantly during steady state discharges, central electron temperature, averaged electron density, electron density profile, and plasma current density profile have been obtained based on the scaling of Z{sub eff} with electron density and the relations between Z{sub eff} and these parameters. The estimated results are in good coincidence with measured values, providing an effective and convenient method to estimate other plasma parameters.

  3. Polarization bremsstrahlung of a hydrogen-like ion in a single crystal

    SciTech Connect

    Astapenko, V. A.

    2009-01-15

    Polarization bremsstrahlung (PB) that arises when a fast hydrogen-like ion is scattered in a single crystal is investigated theoretically. Four types of the process are analyzed that are caused by virtual excitation of electrons of the target and of the incident particle (IP), as well as by a coherent and incoherent interaction between the IP and the single crystal. The spectral, angular, and velocity (of the IP) characteristics of PB are calculated with regard to the spectral function of a photodetector. Optimal observation conditions and regions in which different types of PB are dominant are determined, and the dependence of these regions on the charge of the IP nucleus and of the target atoms is revealed.

  4. Thick-target bremsstrahlung interpretation of short time-scale solar hard X-ray features

    NASA Technical Reports Server (NTRS)

    Emslie, A. G.

    1983-01-01

    Steady-state analyses of bremsstrahlung hard X-ray production in solar flares are appropriate only if the lifetime of the high energy electrons in the X-ray source is much shorter than the duration of the observed X-ray burst. For a thick-target nonthermal model, this implies that a full time-dependent analysis is required when the duration of the burst is comparable to the collisional lifetime of the injected electrons, in turn set by the lengths and densities of the flaring region. In this paper we present the results of such a time-dependent analysis, and we point out that the intrinsic temporal signature of the thick-target production mechanism, caused by the finite travel time of the electrons through the target, may indeed rule out such a mechanism for extremely short duration hard X-ray events.

  5. Inverse Bremsstrahlung in Astrophysical Plasmas: The Absorption Coefficients and Gaunt Factors

    NASA Astrophysics Data System (ADS)

    Mihajlov, A. A.; Srećković, V. A.; Sakan, N. M.

    2015-12-01

    The electron-ion inverse Bremsstrahlung is considered here as a factor of the influence on the opacity of the different stellar atmospheres and other astrophysical plasmas. It is shown that this process can be successfully described in the frames of cut-off Coulomb potential model within the regions of the electron densities and temperatures. The relevant quantum mechanical method of the calculation of the corresponding spectral coefficient processes is described and discussed. The results obtained for the plasmas with the electron densities from 1014 c m -3 to 2ṡ1019 c m -3 and temperatures from 5ṡ103 K to 3ṡ104 K in the wavelength region 100 nm< λ<3000 nm are presented. Also, these results can be of interest for different laboratory plasmas.

  6. Bremsstrahlung and Line Spectroscopy of Warm Dense Aluminum Plasma Generated by EUV Free Electron Laser

    SciTech Connect

    Zastrau, U; Fortmann, C; Faustlin, R; Bornath, T; Cao, L F; Doppner, T; Dusterer, S; Forster, E; Glenzer, S H; Gregori, G; Holl, A; Laarmann, T; Lee, H; Meiwes-Broer, K; Przystawik, A; Radcliffe, P; Redmer, R; Reinholz, H; Ropke, G; Tiggesbaumker, J; Thiele, R; Truong, N X; Uschmann, I; Toleikis, S; Tschentscher, T; Wierling, A

    2008-03-07

    We report on the novel creation of a solid density aluminum plasma using free electron laser radiation at 13.5 nm wavelength. Ultrashort pulses of 30 fs duration and 47 {micro}J pulse energy were focused on a spot of 25 {micro}m diameter, yielding an intensity of 3 x 10{sup 14} W/cm{sup 2} on the bulk Al-target. The radiation emitted from the plasma was measured using a high resolution, high throughput EUV spectrometer. The analysis of both bremsstrahlung and line spectra results in an estimated electron temperature of (30 {+-} 10) eV, which is in very good agreement with radiation hydrodynamics simulations of the laser-target-interaction. This demonstrates the feasibility of exciting plasmas at warm dense matter conditions using EUV free electron lasers and their accurate characterization by EUV spectroscopy.

  7. Potential enhancement of warm x-ray dose from a reflexing bremsstrahlung diode

    SciTech Connect

    Sanford, T.W.L.; Halbleib, J.A.; Cooperstein, G.; Weber, B.V.

    1995-07-01

    The potential for generating intense bursts of war x rays (20 to 60 keV) using electron reflexing diodes on pulsed-power accelerators is evaluated with the TIGER Monte Carlo code, showing that hundreds of kilojoules of warm x rays can be generated under idealized conditions. The calculation are compared with data from Gamble-II experiments and applied to two suggest Jupiter (60-MA, 5-MV, 100-ns) diode configurations. If the simultaneous irradiation from the high-energy tail of the bremsstrahlung which accompanies the warm x rays is a concern, then the reflexing technique is shown to be limited to the irradiation of targets thinner than {approximately} 400 {mu}m for low-Z targets like aluminum and thinner than {approximately} 5 {mu}m for high-Z targets like gold.

  8. Potential enhancement of warm X-ray dose from a reflexing bremsstrahlung diode

    SciTech Connect

    Sanford, T.W.L.; Halbleib, J.A.; Cooperstein, G.

    1995-08-01

    The potential for generating intense bursts of warm x rays (20 to 60 keV) using electron reflexing diodes on pulsed-power accelerators is evaluated with the TIGER Monte Carlo code, showing that hundreds of kilojoules of warm x rays can be generated under idealized conditions, for a Jupiter (60-MA, 5-MV, 100-ns) class accelerator. The calculations are compared with data from Gamble-II experiments and applied to two suggested Jupiter diode configurations. If the simultaneous irradiation from the high-energy tail of the bremsstrahlung, which accompanies the warm x rays, is a concern then the reflexing technique is shown to be limited to the irradiation of targets thinner than {approximately}400 {mu}m for low-Z targets like aluminum and thinner than {approximately}5 {mu}m for high-Z targets like gold.

  9. Directivity of Bremsstrahlung radiation from relativistic beams and the Gamma-Rays from solar flares

    NASA Technical Reports Server (NTRS)

    Petrosian, V.

    1985-01-01

    It has been observed that flares with greater than 10 Mev gamma-ray emission are concentrated around the solar limb with a dispersion of 10 to 20 degrees. It is shown that the bremsstrahlung by relativistic electrons is responsible for such gamma-rays and that the expected relativistic beaming cannot explain this dispersion. It is argued that this dispersion is predominately a reflection of the pitch angle distribution of the electrons. Then it is shown that this requires a small variation of the magnetic field from the point where the electrons are injected to the photosphere and a nearly isotropic (in the downward direction) pitch angle distribution at the injection. The influence of other effects on the observed distribution is also discussed.

  10. Threshold and spin factors in the yield of bremsstrahlung-induced reactions

    SciTech Connect

    Karamian, S. A.

    2013-12-15

    Relative yields of photon-induced reactions are systematized in a function of the threshold parameter for moderately heavy targets at the bremsstrahlung end-point energy lower than 30 MeV. Regular dependence is established for the group of (γ, n), (γ, p), and (γ, d) reactions, while the yields of (γ, 2n) and (γ,α) reactions deviate from the regularity. Physical conclusions are discussed and possible application of this systematic for data processing is proposed. In particular, the constituent threshold and spin factors in the isomer-to-ground-state ratio could be isolated separately. For spin dependence of the yields, a new regularization parameter is introduced and previously hidden peculiarities are concluded.

  11. Bremsstrahlung production at 50 MeV in different target materials and configurations.

    PubMed

    Sätherberg, A; Andreo, P; Karlsson, M

    1996-04-01

    A combination of Monte Carlo, convolution, and experimental techniques have been used to investigate bremsstrahlung production at 50 MeV in full-range targets to produce narrow elementary photon beams for scanning. Calculations using the ITS 3.0 Monte Carlo system for various target designs, including particle transport through the treatment head of an MM5O racetrack microtron and a water phantom, have been compared to experimental dose profiles from narrow photon beams at 10-cm depth in water. A reduction in the ITS 3.0 default substep size has been found necessary even for incomplete agreement, in consistency with the findings of Faddegon and Rogers [Nucl. Instrum. Meth. A 327, 556-565 (1993)] for a different experimental setup and energy using the previous version of ITS. Results show that the calculated shape of the tail of dose distributions from narrow photon beams agrees well with measurements, but CYLTRAN/ITS 3.0 fails to reproduce the central part of the distribution. The discrepancy at small angles, reported previously for EGS4 and ITS 2.1 simulations, possess a limitation to Monte Carlo simulations of narrow photon beams used in scanned systems of clinical accelerators. Radial dose profiles have been calculated by convolution of the energy fluence at the exit of the target with one polyenergetic Monte Carlo calculated dose kernel and also a database consisting of ten different dose kernels corresponding to different monoenergetic photon pencil beams for comparison. The agreement with the much slower fully detailed Monte Carlo calculations was better when using the database kernels than the polyenergetic kernel. Results for the mean energy, mean polar angle, and energy fluence at different depths within various targets have been obtained. These are discussed in the context of the design characteristics of bremsstrahlung targets with emphasis on their utilization for scanning photon beam techniques. PMID:9157260

  12. Validation of the GEANT4 simulation of bremsstrahlung from thick targets below 3 MeV

    NASA Astrophysics Data System (ADS)

    Pandola, L.; Andenna, C.; Caccia, B.

    2015-05-01

    The bremsstrahlung spectra produced by electrons impinging on thick targets are simulated using the GEANT4 Monte Carlo toolkit. Simulations are validated against experimental data available in literature for a range of energy between 0.5 and 2.8 MeV for Al and Fe targets and for a value of energy of 70 keV for Al, Ag, W and Pb targets. The energy spectra for the different configurations of emission angles, energies and targets are considered. Simulations are performed by using the three alternative sets of electromagnetic models that are available in GEANT4 to describe bremsstrahlung. At higher energies (0.5-2.8 MeV) of the impinging electrons on Al and Fe targets, GEANT4 is able to reproduce the spectral shapes and the integral photon emission in the forward direction. The agreement is within 10-30%, depending on energy, emission angle and target material. The physics model based on the Penelope Monte Carlo code is in slightly better agreement with the measured data than the other two. However, all models over-estimate the photon emission in the backward hemisphere. For the lower energy study (70 keV), which includes higher-Z targets, all models systematically under-estimate the total photon yield, providing agreement between 10% and 50%. The results of this work are of potential interest for medical physics applications, where knowledge of the energy spectra and angular distributions of photons is needed for accurate dose calculations with Monte Carlo and other fluence-based methods.

  13. Fermi LAT search for internal bremsstrahlung signatures from dark matter annihilation

    SciTech Connect

    Bringmann, Torsten; Huang, Xiaoyuan; Ibarra, Alejandro; Vogl, Stefan; Weniger, Christoph E-mail: x_huang@bao.ac.cn E-mail: stefan.vogl@tum.de

    2012-07-01

    A commonly encountered obstacle in indirect searches for galactic dark matter is how to disentangle possible signals from astrophysical backgrounds. Given that such signals are most likely subdominant, the search for pronounced spectral features plays a key role for indirect detection experiments; monochromatic gamma-ray lines or similar features related to internal bremsstrahlung, in particular, provide smoking gun signatures. We perform a dedicated search for the latter in the data taken by the Fermi gamma-ray space telescope during its first 43 months. To this end, we use a new adaptive procedure to select optimal target regions that takes into account both standard and contracted dark matter profiles. The behaviour of our statistical method is tested by a subsampling analysis of the full sky data and found to reproduce the theoretical expectations very well. The limits on the dark matter annihilation cross-section that we derive are stronger than what can be obtained from the observation of dwarf galaxies and, at least for the model considered here, collider searches. While these limits are still not quite strong enough to probe annihilation rates expected for thermally produced dark matter, future prospects to do so are very good. In fact, we already find a weak indication, with a significance of 3.1σ (4.3σ) when (not) taking into account the look-elsewhere effect, for an internal bremsstrahlung-like signal that would correspond to a dark matter mass of ∼150 GeV; the same signal is also well fitted by a gamma-ray line at around 130 GeV. Although this would be a fascinating possibility, we caution that a much more dedicated analysis and additional data will be necessary to rule out or confirm this option.

  14. Fermi LAT search for internal bremsstrahlung signatures from dark matter annihilation

    NASA Astrophysics Data System (ADS)

    Bringmann, Torsten; Huang, Xiaoyuan; Ibarra, Alejandro; Vogl, Stefan; Weniger, Christoph

    2012-07-01

    A commonly encountered obstacle in indirect searches for galactic dark matter is how to disentangle possible signals from astrophysical backgrounds. Given that such signals are most likely subdominant, the search for pronounced spectral features plays a key role for indirect detection experiments; monochromatic gamma-ray lines or similar features related to internal bremsstrahlung, in particular, provide smoking gun signatures. We perform a dedicated search for the latter in the data taken by the Fermi gamma-ray space telescope during its first 43 months. To this end, we use a new adaptive procedure to select optimal target regions that takes into account both standard and contracted dark matter profiles. The behaviour of our statistical method is tested by a subsampling analysis of the full sky data and found to reproduce the theoretical expectations very well. The limits on the dark matter annihilation cross-section that we derive are stronger than what can be obtained from the observation of dwarf galaxies and, at least for the model considered here, collider searches. While these limits are still not quite strong enough to probe annihilation rates expected for thermally produced dark matter, future prospects to do so are very good. In fact, we already find a weak indication, with a significance of 3.1σ (4.3σ) when (not) taking into account the look-elsewhere effect, for an internal bremsstrahlung-like signal that would correspond to a dark matter mass of ~150 GeV; the same signal is also well fitted by a gamma-ray line at around 130 GeV. Although this would be a fascinating possibility, we caution that a much more dedicated analysis and additional data will be necessary to rule out or confirm this option.

  15. Inverse bremsstrahlung cross section estimated within evolving plasmas using effective ion potentials

    NASA Astrophysics Data System (ADS)

    Wang, F.; Weckert, E.; Ziaja, B.

    2009-06-01

    We estimate the total cross sections for field-stimulated photoemissions and photoabsorptions by quasi-free electrons within a non-equilibrium plasma evolving from the strong coupling to the weak coupling regime. Such a transition may occur within laser-created plasmas, when the initially created plasma is cold but the heating of the plasma by the laser field is efficient. In particular, such a transition may occur within plasmas created by intense vacuum ultraviolet (VUV) radiation from a free-electron laser (FEL) as indicated by the results of the first experiments performed by Wabnitz at the FLASH facility at DESY. In order to estimate the inverse bremsstrahlung cross sections, we use point-like and effective atomic potentials. For ions modelled as point-like charges, the total cross sections are strongly affected by the changing plasma environment. The maximal change of the cross sections may be of the order of 75 at the change of the plasma parameters: inverse Debye length, κ, in the range κ = 0 - 3 Å-1 and the electron density, ρe, in the range ρe = 0.01 - 1 Å-3. These ranges correspond to the physical conditions within the plasmas created during the first cluster experiments performed at the FLASH facility at DESY. In contrast, for the effective atomic potentials the total cross sections for photoemission and photoabsorption change only by a factor of seven at most in the same plasma parameter range. Our results show that the inverse bremsstrahlung cross section estimated with the effective atomic potentials is not affected much by the plasma environment. This observation validates the estimations of the enhanced heating effect obtained by Walters, Santra and Greene. This is important as this effect may be responsible for the high-energy absorption within clusters irradiated with VUV radiation.

  16. Modeling Relativistic Electron Precipitation Bremsstrahlung X-Ray Intensities at 10-100 km Manned Vehicle Altitudes

    NASA Technical Reports Server (NTRS)

    Krause, L. Habsh; Gilchrist, B. E.; Nishikawa, Ken-Ichi

    2013-01-01

    Relativisitic electron precipitation (REP) events occur when beams or bunches of relativistic electrons of magnetospheric origin enter the Earth's atmosphere, typically at auroral latitudes. REP events are associated with a variety of space weather effects, including production of transitional and bremsstrahlung radiation, catalytic depletion of stratospheric ozone, and scintillation of transionospheric radio waves. This study examines the intensities of x-rays produced at airliner, manned balloon, and space reuseable launch vehicles (sRLVs). The monoenergetic beam is modeled in cylindrical symetry using the paraxial ray equation. Bremsstrahlung photon production is calculated using the traditional Sauter-Elwert cross-section, providing x-ray emission spectra differential in energy and angle. Attenuation is computed for a plane-stratified standard atmosphere, and the loss processes include photoionization, Rayleigh and Compton scattering, electron-positron pair production, and photonuclear interaction. Peak altitudes of electron energy deposition and bremsstrahlung x-ray production were calculated for beams of energies from 1 MeV through 100 MeV. The altitude peak of bremsstrahlung deposition was consistently and significantly lower that that of the electron deposition due to the longer mean free paths of x-rays compared to electrons within the atmosphere. For example, for a nadir-directed monoenergetic 5 MeV beam, the peak deposition altitude was calculated to be 42 km, but the resulting bremsstrahlung deposition peaked at 25 km. This has implications for crew and passenger safety, especially with the growth of the space tourism industry. A survey of results covering the 1-100 MeV spectrum for the three altitude ranges of interest will be presented.

  17. Bremsstrahlung in Mo and Pt targets produced by {sup 90}Sr beta particles in the photon energy region of 1-100 keV

    SciTech Connect

    Singh, Amrit; Dhaliwal, A. S.

    2015-08-28

    Bremsstrahlung spectra in thick targets of Mo and Pt, produced by beta emitter {sup 90}Sr (end point energy = 546 keV) have been studied in the photon energy range of 1-100 keV. The experimentally measured bremsstrahlung spectra measured with Si(Li) detector were compared with the theoretical spectral distributions calculated from Elwert corrected (non relativistic) Bethe-Heitler [EBH] theory, modified Elwert factor (relativistic) Bethe-Heitler (F{sub mod}BH) theory for ordinary bremsstrahlung (OB) and the modified Elwert factor (relativistic) Bethe-Heitler (F{sub mod}BH+PB) theory, which includes the polarization bremsstrahlung (PB) into total bremsstrahlung (BS). The present results indicate the correctness of F{sub mod}BH+PB theory in the low energy region, where the contributions of PB into BS are dominant, which is described in terms of stripped atom (SA) approximation. But at the middle and higher energy region of the bremsstrahlung spectrum, where the contribution of PB is negligible, the F{sub mod}BH theory is more close to the experimental results. Hence, it is clear that the production of PB in the low energy region, due to the dynamic response of the target atom suppresses the production of bremsstrahlung at higher energy ends.

  18. Bremsstrahlung in Mo and Pt targets produced by 90Sr beta particles in the photon energy region of 1-100 keV

    NASA Astrophysics Data System (ADS)

    Singh, Amrit; Dhaliwal, A. S.

    2015-08-01

    Bremsstrahlung spectra in thick targets of Mo and Pt, produced by beta emitter 90Sr (end point energy = 546 keV) have been studied in the photon energy range of 1-100 keV. The experimentally measured bremsstrahlung spectra measured with Si(Li) detector were compared with the theoretical spectral distributions calculated from Elwert corrected (non relativistic) Bethe-Heitler [EBH] theory, modified Elwert factor (relativistic) Bethe-Heitler (FmodBH) theory for ordinary bremsstrahlung (OB) and the modified Elwert factor (relativistic) Bethe-Heitler (FmodBH+PB) theory, which includes the polarization bremsstrahlung (PB) into total bremsstrahlung (BS). The present results indicate the correctness of FmodBH+PB theory in the low energy region, where the contributions of PB into BS are dominant, which is described in terms of stripped atom (SA) approximation. But at the middle and higher energy region of the bremsstrahlung spectrum, where the contribution of PB is negligible, the FmodBH theory is more close to the experimental results. Hence, it is clear that the production of PB in the low energy region, due to the dynamic response of the target atom suppresses the production of bremsstrahlung at higher energy ends.

  19. Differences in 3D dose distributions due to calculation method of voxel S-values and the influence of image blurring in SPECT

    NASA Astrophysics Data System (ADS)

    Pacilio, Massimiliano; Amato, Ernesto; Lanconelli, Nico; Basile, Chiara; Torres, Leonel Alberto; Botta, Francesca; Ferrari, Mahila; Cornejo Diaz, Nestor; Coca Perez, Marco; Fernández, María; Lassmann, Michael; Vergara Gil, Alex; Cremonesi, Marta

    2015-03-01

    This study compares 3D dose distributions obtained with voxel S values (VSVs) for soft tissue, calculated by several methods at their current state-of-the-art, varying the degree of image blurring. The methods were: 1) convolution of Dose Point Kernel (DPK) for water, using a scaling factor method; 2) an analytical model (AM), fitting the deposited energy as a function of the source-target distance; 3) a rescaling method (RSM) based on a set of high-resolution VSVs for each isotope; 4) local energy deposition (LED). VSVs calculated by direct Monte Carlo simulations were assumed as reference. Dose distributions were calculated considering spheroidal clusters with various sizes (251, 1237 and 4139 voxels of 3 mm size), uniformly filled with 131I, 177Lu, 188Re or 90Y. The activity distributions were blurred with Gaussian filters of various widths (6, 8 and 12 mm). Moreover, 3D-dosimetry was performed for 10 treatments with 90Y derivatives. Cumulative Dose Volume Histograms (cDVHs) were compared, studying the differences in D95%, D50% or Dmax (ΔD95%, ΔD50% and ΔDmax) and dose profiles. For unblurred spheroidal clusters, ΔD95%, ΔD50% and ΔDmax were mostly within some percents, slightly higher for 177Lu with DPK (8%) and RSM (12%) and considerably higher for LED (ΔD95% up to 59%). Increasing the blurring, differences decreased and also LED yielded very similar results, but D95% and D50% underestimations between 30-60% and 15-50%, respectively (with respect to 3D-dosimetry with unblurred distributions), were evidenced. Also for clinical images (affected by blurring as well), cDVHs differences for most methods were within few percents, except for slightly higher differences with LED, and almost systematic for dose profiles with DPK (-1.2%), AM (-3.0%) and RSM (4.5%), whereas showed an oscillating trend with LED. The major concern for 3D-dosimetry on clinical SPECT images is more strongly represented by image blurring than by differences among the VSVs

  20. Small hepatocellular carcinomas in chronic liver disease: Detection with SPECT

    SciTech Connect

    Kudo, M.; Hirasa, M.; Takakuwa, H.; Ibuki, Y.; Fujimi, K.; Miyamura, M.; Tomita, S.; Komori, H.; Todo, A.; Kitaura, Y.

    1986-06-01

    Single-photon emission computed tomography (SPECT) performed using a rotating gamma camera was compared with ..cap alpha../sub 1/-fetoprotein (AFP) assay, conventional liver scintigraphy, ultrasound (US) imaging, computed tomography (CT), and selective celiac angiography in 40 patients with a total of 50 small hepatocellular carcinomas (HCCs;<5 cm). The detection rates of US and CT were determined on an initial screening study and on a second, more precisely focused study. The detection rate of small HCCs by the various modalities was as follows: AFP, 13%; liver scintigraphy, 36%; SPECT, 72%; initial screening US, 80%; second, more precise US studies, 94%; initial screening CT, 64%; second, more precise CT study, 82%; angiography, 88%. Although SPECT was inferior to the initial screening US examination in detecting HCCs less than 2 cm in size, its sensitivity was identical to that of the initial screening US study for detecting HCCs of 2-5 cm. The combination of SPECT and US was an excellent method for the early detection of HCCs, yielding a detection rate of 94%.

  1. Molecular Imaging of Conscious, Unrestrained Mice with AwakeSPECT

    PubMed Central

    Baba, Justin S.; Endres, Christopher J.; Foss, Catherine A.; Nimmagadda, Sridhar; Jung, Hyeyun; Goddard, James S.; Lee, Seungjoon; McKisson, John; Smith, Mark F.; Stolin, Alexander V.; Weisenberger, Andrew G.; Pomper, Martin G.

    2014-01-01

    We have developed a SPECT imaging system, AwakeSPECT, to enable molecular brain imaging of untrained mice that are conscious, unanesthetized, and unrestrained. We accomplished this with head tracking and motion correction techniques. Methods: The capability of the system for motion-corrected imaging was demonstrated with a 99mTc-pertechnetate phantom, 99mTcmethylene diphosphonate bone imaging, and measurement of the binding potential of the dopamine transporter radioligand 123I-ioflupane in mouse brain in the awake and anesthetized (isoflurane) states. Stress induced by imaging in the awake state was assessed through measurement of plasma corticosterone levels. Results: AwakeSPECT provided high-resolution bone images reminiscent of those obtained from CT. The binding potential of 123I-ioflupane in the awake state was on the order of 50% of that obtained with the animal under anesthesia, consistent with previous studies in nonhuman primates. Levels of stress induced were on the order of those seen in other behavioral tasks and imaging studies of awake animals. Conclusion: These results demonstrate the feasibility of SPECT molecular brain imaging of mice in the conscious, unrestrained state and demonstrate the effects of isoflurane anesthesia on radiotracer uptake. PMID:23536223

  2. Nonlinear dual reconstruction of SPECT activity and attenuation images.

    PubMed

    Liu, Huafeng; Guo, Min; Hu, Zhenghui; Shi, Pengcheng; Hu, Hongjie

    2014-01-01

    In single photon emission computed tomography (SPECT), accurate attenuation maps are needed to perform essential attenuation compensation for high quality radioactivity estimation. Formulating the SPECT activity and attenuation reconstruction tasks as coupled signal estimation and system parameter identification problems, where the activity distribution and the attenuation parameter are treated as random variables with known prior statistics, we present a nonlinear dual reconstruction scheme based on the unscented Kalman filtering (UKF) principles. In this effort, the dynamic changes of the organ radioactivity distribution are described through state space evolution equations, while the photon-counting SPECT projection data are measured through the observation equations. Activity distribution is then estimated with sub-optimal fixed attenuation parameters, followed by attenuation map reconstruction given these activity estimates. Such coupled estimation processes are iteratively repeated as necessary until convergence. The results obtained from Monte Carlo simulated data, physical phantom, and real SPECT scans demonstrate the improved performance of the proposed method both from visual inspection of the images and a quantitative evaluation, compared to the widely used EM-ML algorithms. The dual estimation framework has the potential to be useful for estimating the attenuation map from emission data only and thus benefit the radioactivity reconstruction. PMID:25225796

  3. Thallium-201 accumulation in cerebral candidiasis: Unexpected finding on SPECT

    SciTech Connect

    Tonami, N.; Matsuda, H.; Ooba, H.; Yokoyama, K.; Hisada, K.; Ikeda, K.; Yamashita, J. )

    1990-06-01

    The authors present an unexpected finding of Tl-201 uptake in the intracerebral lesions due to candidiasis. SPECT demonstrated the extent of the lesions and a high target-to-background ratio. The regions where abnormal Tl-201 accumulation was seen were nearly consistent with CT scans of those enhanced by a contrast agent. After treatment, most of the abnormal Tl-201 accumulation disappeared.

  4. Hemimegalencephaly: Clinical, EEG, neuroimaging, and IMP-SPECT correlation

    SciTech Connect

    Konkol, R.J.; Maister, B.H.; Wells, R.G.; Sty, J.R. )

    1990-11-01

    Iofetamine-single photon emission computed tomography (IMP-SPECT) was performed on 2 girls (5 1/2 and 6 years of age) with histories of intractable seizures, developmental delay, and unilateral hemiparesis secondary to hemimegalencephaly. Electroencephalography (EEG) revealed frequent focal discharges in 1 patient, while a nearly continuous burst suppression pattern over the malformed hemisphere was recorded in the other. IMP-SPECT demonstrated a good correlation with neuroimaging studies. In spite of the different EEG patterns, which had been proposed to predict contrasting clinical outcomes, both IMP-SPECT scans disclosed a similar decrease in tracer uptake in the malformed hemisphere. These results are consistent with the pattern of decreased tracer uptake found in other interictal studies of focal seizures without cerebral malformations. In view of recent recommendations for hemispherectomy in these patients, we suggest that the IMP-SPECT scan be used to compliment EEG as a method to define the extent of abnormality which may be more relevant to long-term prognosis than EEG alone.

  5. Simplifying the Measurement of Gastric Accommodation using SPECT

    PubMed Central

    Vijayvargiya, Priya; Camilleri, Michael; Shin, Andrea; Breen, Mary; Burton, Duane

    2013-01-01

    Background Noninvasive single photon emission computed tomography (SPECT) has been validated as a test for postprandial gastric volume accommodation, with volumes measured twice over 30 minutes and averaged. The purpose of this study is to simplify the SPECT measurement of gastric accommodation. Methods The primary aim of this study was to compare 2 postprandial gastric volume measurements with data collected retrospectively from 443 patients and healthy volunteers who had undergone SPECT in the last decade. The differences in the two gastric volumes were compared in the entire group and each subgroup, and the correlation between the 2 measurements and their differences across a wide range of gastric volumes were plotted. Key Results There was a median difference of <2% (p=0.041) between postprandial scan 1 (757 mL) and scan 2 (743 mL), with significant correlation (rs = 0.859, p<0.01) and excellent agreement (S.D. 60 mL) between the 2 scans across the entire range of observed postprandial gastric volumes. Conclusions & Inferences A single postprandial scan can detect gastric accommodation with the same accuracy as averaging 2 postprandial scans. These data support simplifying SPECT measurement of postprandial gastric volume with a scan in the first 15 minutes after a meal. PMID:23413813

  6. The role of SPECT in the evaluation of skeletal trauma.

    PubMed

    Murray, I P

    1993-02-01

    Single photon emission computed tomography (SPECT) has, in the last decade, established a critical role in routine diagnosis. Skeletal scintigraphy exemplifies the impact in improving detection of lesions by delineation of their site and size. The advantage of minimizing the superimposed radioactivity from overlying and underlying structures is typified by the readiness with which avascular necrosis of the femoral head can be identified by removal of the surrounding hyperaemia which masks the classical photopaenia. However, the ability to achieve an accurate image at a plane at a prescribed depth is most characteristically shown by the study of a vertebra, a bone of irregular contour and subject to a variety of pathological disorders at different sites within it. The various focal abnormalities resulting from these can be localized exactly, readily distinguishing, for example, those in the body from those in the natural arch. In particular, the alterations resulting from trauma, such as pars interarticularis stress fracture, are readily seen. Consequently SPECT has an indispensable role in the investigation and management of low back pain. However, the ability of SPECT to delineate abnormal accumulation has provided a new approach to the evaluation of knee pain, especially when acute such as that resulting from athletic injury, since the identification of the presence or absence of focal abnormalities can be critical to patient management. The frequency of these various disorders in which SPECT is so useful explains why the procedure has become such a routine high-volume examination is so many departments. PMID:8461235

  7. Nonlinear Dual Reconstruction of SPECT Activity and Attenuation Images

    PubMed Central

    Liu, Huafeng; Guo, Min; Hu, Zhenghui; Shi, Pengcheng; Hu, Hongjie

    2014-01-01

    In single photon emission computed tomography (SPECT), accurate attenuation maps are needed to perform essential attenuation compensation for high quality radioactivity estimation. Formulating the SPECT activity and attenuation reconstruction tasks as coupled signal estimation and system parameter identification problems, where the activity distribution and the attenuation parameter are treated as random variables with known prior statistics, we present a nonlinear dual reconstruction scheme based on the unscented Kalman filtering (UKF) principles. In this effort, the dynamic changes of the organ radioactivity distribution are described through state space evolution equations, while the photon-counting SPECT projection data are measured through the observation equations. Activity distribution is then estimated with sub-optimal fixed attenuation parameters, followed by attenuation map reconstruction given these activity estimates. Such coupled estimation processes are iteratively repeated as necessary until convergence. The results obtained from Monte Carlo simulated data, physical phantom, and real SPECT scans demonstrate the improved performance of the proposed method both from visual inspection of the images and a quantitative evaluation, compared to the widely used EM-ML algorithms. The dual estimation framework has the potential to be useful for estimating the attenuation map from emission data only and thus benefit the radioactivity reconstruction. PMID:25225796

  8. V/Q SPECT: utility for investigation of pulmonary physiology.

    PubMed

    King, Gregory G; Harris, Benjamin; Mahadev, Sriram

    2010-11-01

    Single-photon emission computed tomography (SPECT) is being increasingly used as a tool in respiratory research, in particular ventilation SPECT. Much of the basic understanding of pulmonary physiology has been derived from inhaled radioactive inert gases because, as the lung behaves in an asymmetric manner, the nature of regional differences in ventilation is ideally studied with the use of imaging. It is well known to clinicians that ventilation is patchy in patients who have airways disease. However, the relevance to the disease mechanisms itself only started to be studied with the use of 3-dimensional imaging and with advances in quantitative image analysis. The measurements of both ventilation distribution and nonventilation (airway closure) have become very topical in the study of asthma, and accurate quantification of those parameters is of relevance to disease mechanisms. In chronic obstructive pulmonary disease, the drive is towards better characterization of disease groups ("phenotypes") and, again, description of ventilation patterns may prove to be useful. This is a review, therefore, on pulmonary SPECT imaging in respiratory research which includes a focus on methodology in relation to respiratory physiology. There has been relatively little published in this area but there is great potential for advances in the understanding of airways disease to be gained from SPECT imaging. PMID:20920636

  9. Geometric characterization of multi-axis multi-pinhole SPECT

    SciTech Connect

    DiFilippo, Frank P.

    2008-01-15

    A geometric model and calibration process are developed for single photon emission computed tomography (SPECT) imaging with multiple pinholes and multiple mechanical axes. Unlike the typical situation where pinhole collimators are mounted directly to rotating gamma ray detectors, this geometric model allows for independent rotation of the detectors and pinholes, for the case where the pinhole collimator is physically detached from the detectors. This geometric model is applied to a prototype small animal SPECT device with a total of 22 pinholes and which uses dual clinical SPECT detectors. All free parameters in the model are estimated from a calibration scan of point sources and without the need for a precision point source phantom. For a full calibration of this device, a scan of four point sources with 360 deg. rotation is suitable for estimating all 95 free parameters of the geometric model. After a full calibration, a rapid calibration scan of two point sources with 180 deg. rotation is suitable for estimating the subset of 22 parameters associated with repositioning the collimation device relative to the detectors. The high accuracy of the calibration process is validated experimentally. Residual differences between predicted and measured coordinates are normally distributed with 0.8 mm full width at half maximum and are estimated to contribute 0.12 mm root mean square to the reconstructed spatial resolution. Since this error is small compared to other contributions arising from the pinhole diameter and the detector, the accuracy of the calibration is sufficient for high resolution small animal SPECT imaging.

  10. [Radionuclide cisternography: SPECT- and 3D-technique].

    PubMed

    Henkes, H; Huber, G; Hierholzer, J; Cordes, M; Kujat, C; Piepgras, U

    1991-10-01

    Radionuclide cisternography is indicated in the clinical work-up for hydrocephalus, when searching for CSF leaks, and when testing whether or not intracranial cystic lesions are communicating with the adjacent subarachnoid space. This paper demonstrates the feasibility and diagnostic value of SPECT and subsequent 3D surface rendering in addition to conventional rectilinear CSF imaging in eight patients. Planar images allowed the evaluation of CSF circulation and the detection of CSF fistula. They were advantageous in examinations 48 h after application of 111In-DTPA. SPECT scans, generated 4-24 h after tracer application, were superior in the delineation of basal cisterns, especially in early scans; this was helpful in patients with pooling due to CSF fistula and in cystic lesions near the skull base. A major drawback was the limited image quality of delayed scans, when the SPECT data were degraded by a low count rate. 3D surface rendering was easily feasible from SPECT data and yielded high quality images. The presentation of the spatial distribution of nuclide-contaminated CSF proved especially helpful in the area of the basal cisterns. PMID:1956980

  11. Molecular Imaging of Conscious, Unrestrained Mice with AwakeSPECT

    SciTech Connect

    Baba, Justin S.; Endres, Christopher J.; Foss, Catherine A.; Nimmagadda, Sridhar; Jung, Hyeyun; Goddard, James S.; Lee, Seung Joon; McKisson, John; Smith, Mark F.; Stolin, Alexander V.; Weisenberger, Andrew G.; Pomper, Martin G.

    2013-06-01

    We have developed a SPECT imaging system, AwakeSPECT, to enable molecular brain imaging of untrained mice that are conscious, unanesthetized, and unrestrained. We accomplished this with head tracking and motion correction techniques. Methods: The capability of the system for motion-corrected imaging was demonstrated with a ^99mTc-pertechnetate phantom, ^99mTc-methylene diphosphonate bone imaging, and measurement of the binding potential of the dopamine transporter radioligand ^123I-ioflupane in mouse brain in the awake and anesthetized (isoflurane) states. Stress induced by imaging in the awake state was assessed through measurement of plasma corticosterone levels. Results: AwakeSPECT provided high-resolution bone images reminiscent of those obtained from CT. The binding potential of ^123I-ioflupane in the awake state was on the order of 50% of that obtained with the animal under anesthesia, consistent with previous studies in nonhuman primates. Levels of stress induced were on the order of those seen in other behavioral tasks and imaging studies of awake animals. Conclusion: These results demonstrate the feasibility of SPECT molecular brain imaging of mice in the conscious, unrestrained state and demonstrate the effects of isoflurane anesthesia on radiotracer uptake.

  12. Molecular Imaging of Conscious, Unrestrained Mice with AwakeSPECT

    SciTech Connect

    Baba, Justin S; Endres, Christopher; Foss, Catherine; Nimmagadda, Sridhar; Jung, Hyeyun; Goddard Jr, James Samuel; Lee, Seung Joon; McKisson, John; Smith, Mark F.; Stolin, Alexander; Weisenberger, Andrew G.; Pomper, Martin

    2013-01-01

    We have developed a SPECT imaging system, AwakeSPECT, to enable molecular brain imaging of untrained mice that are conscious, unanesthetized, and unrestrained. We accomplished this with head tracking and motion correction techniques. Methods: The capability of the system for motion-corrected imaging was demonstrated with a 99mTc-pertechnetate phantom, 99mTcmethylene diphosphonate bone imaging, and measurement of the binding potential of the dopamine transporter radioligand 123I-ioflupane in mouse brain in the awake and anesthetized (isoflurane) states. Stress induced by imaging in the awake state was assessed through measurement of plasma corticosterone levels. Results: AwakeSPECT provided high-resolution bone images reminiscent of those obtained from CT. The binding potential of 123I-ioflupane in the awake state was on the order of 50% of that obtained with the animal under anesthesia, consistent with previous studies in nonhuman primates. Levels of stress induced were on the order of those seen in other behavioral tasks and imaging studies of awake animals. Conclusion: These results demonstrate the feasibility of SPECT molecular brain imaging of mice in the conscious, unrestrained state and demonstrate the effects of isoflurane anesthesia on radiotracer uptake.

  13. A COMPUTER MODEL OF LUNG MORPHOLOGY TO ANALYZE SPECT IMAGES

    EPA Science Inventory

    Measurement of the three-dimensional (3-D) spatial distribution of aerosol deposition can be performed using Single Photon Emission Computed Tomography (SPECT). The advantage of using 3-D techniques over planar gamma imaging is that deposition patterns can be related to real lun...

  14. Collimator design for a multipinhole brain SPECT insert for MRI

    SciTech Connect

    Van Audenhaege, Karen; Van Holen, Roel; Vanhove, Christian; Vandenberghe, Stefaan

    2015-11-15

    Purpose: Brain single photon emission computed tomography (SPECT) imaging is an important clinical tool, with unique tracers for studying neurological diseases. Nowadays, most commercial SPECT systems are combined with x-ray computed tomography (CT) in so-called SPECT/CT systems to obtain an anatomical background for the functional information. However, while CT images have a high spatial resolution, they have a low soft-tissue contrast, which is an important disadvantage for brain imaging. Magnetic resonance imaging (MRI), on the other hand, has a very high soft-tissue contrast and does not involve extra ionizing radiation. Therefore, the authors designed a brain SPECT insert that can operate inside a clinical MRI. Methods: The authors designed and simulated a compact stationary multipinhole SPECT insert based on digital silicon photomultiplier detector modules, which have shown to be MR-compatible and have an excellent intrinsic resolution (0.5 mm) when combined with a monolithic 2 mm thick LYSO crystal. First, the authors optimized the different parameters of the SPECT system to maximize sensitivity for a given target resolution of 7.2 mm in the center of the field-of-view, given the spatial constraints of the MR system. Second, the authors performed noiseless simulations of two multipinhole configurations to evaluate sampling and reconstructed resolution. Finally, the authors performed Monte Carlo simulations and compared the SPECT insert with a clinical system with ultrahigh-resolution (UHR) fan beam collimators, based on contrast-to-noise ratio and a visual comparison of a Hoffman phantom with a 9 mm cold lesion. Results: The optimization resulted in a stationary multipinhole system with a collimator radius of 150.2 mm and a detector radius of 172.67 mm, which corresponds to four rings of 34 diSPM detector modules. This allows the authors to include eight rings of 24 pinholes, which results in a system volume sensitivity of 395 cps/MBq. Noiseless simulations

  15. Partial volume correction in SPECT reconstruction with OSEM

    NASA Astrophysics Data System (ADS)

    Erlandsson, Kjell; Thomas, Ben; Dickson, John; Hutton, Brian F.

    2011-08-01

    SPECT images suffer from poor spatial resolution, which leads to partial volume effects due to cross-talk between different anatomical regions. By utilising high-resolution structural images (CT or MRI) it is possible to compensate for these effects. Traditional partial volume correction (PVC) methods suffer from various limitations, such as correcting a single region only, returning only regional mean values, or assuming a stationary point spread function (PSF). We recently presented a novel method in which PVC was combined with the reconstruction process in order to take into account the distance dependent PSF in SPECT, which was based on filtered backprojection (FBP) reconstruction. We now present a new method based on the iterative OSEM algorithm, which has advantageous noise properties compared to FBP. We have applied this method to a series of 10 brain SPECT studies performed on healthy volunteers using the DATSCAN tracer. T1-weighted MRI images were co-registered to the SPECT data and segmented into 33 anatomical regions. The SPECT data were reconstructed using OSEM, and PVC was applied in the projection domain at each iteration. The correction factors were calculated by forward projection of a piece-wise constant image, generated from the segmented MRI. Images were also reconstructed using FBP and standard OSEM with and without resolution recovery (RR) for comparison. The images were evaluated in terms of striatal contrast and regional variability (CoV). The mean striatal contrast obtained with OSEM, OSEM-RR and OSEM-PVC relative to FBP were 1.04, 1.42 and 1.53, respectively, and the mean striatal CoV values are 1.05, 1.53, 1.07. Both OSEM-RR and OSEM-PVC results in images with significantly higher contrast as compared to FBP or OSEM, but OSEM-PVC avoids the increased regional variability of OSEM-RR due to improved structural definition.

  16. Benchmarking of Monte Carlo simulation of bremsstrahlung from thick targets at radiotherapy energies

    SciTech Connect

    Faddegon, Bruce A.; Asai, Makoto; Perl, Joseph; Ross, Carl; Sempau, Josep; Tinslay, Jane; Salvat, Francesc

    2008-10-15

    Several Monte Carlo systems were benchmarked against published measurements of bremsstrahlung yield from thick targets for 10-30 MV beams. The quantity measured was photon fluence at 1 m per unit energy per incident electron (spectra), and total photon fluence, integrated over energy, per incident electron (photon yield). Results were reported at 10-30 MV on the beam axis for Al and Pb targets and at 15 MV at angles out to 90 degree sign for Be, Al, and Pb targets. Beam energy was revised with improved accuracy of 0.5% using an improved energy calibration of the accelerator. Recently released versions of the Monte Carlo systems EGSNRC, GEANT4, and PENELOPE were benchmarked against the published measurements using the revised beam energies. Monte Carlo simulation was capable of calculation of photon yield in the experimental geometry to 5% out to 30 degree sign , 10% at wider angles, and photon spectra to 10% at intermediate photon energies, 15% at lower energies. Accuracy of measured photon yield from 0 to 30 degree sign was 5%, 1 s.d., increasing to 7% for the larger angles. EGSNRC and PENELOPE results were within 2 s.d. of the measured photon yield at all beam energies and angles, GEANT4 within 3 s.d. Photon yield at nonzero angles for angles covering conventional field sizes used in radiotherapy (out to 10 degree sign ), measured with an accuracy of 3%, was calculated within 1 s.d. of measurement for EGSNRC, 2 s.d. for PENELOPE and GEANT4. Calculated spectra closely matched measurement at photon energies over 5 MeV. Photon spectra near 5 MeV were underestimated by as much as 10% by all three codes. The photon spectra below 2-3 MeV for the Be and Al targets and small angles were overestimated by up to 15% when using EGSNRC and PENELOPE, 20% with GEANT4. EGSNRC results with the NIST option for the bremsstrahlung cross section were preferred over the alternative cross section available in EGSNRC and over EGS4. GEANT4 results calculated with the ''low energy

  17. Pulsed Bremsstrahlung Interrogation with Photoneutron - Gamma-Ray Spectrometry for Nondestructive Evaluation

    NASA Astrophysics Data System (ADS)

    Jones, James Litton

    A novel photoneutron-based nondestructive evaluation (NDE) technique which does not require a radioactive neutron source is presented. Some unique features of this technique include: 1) pulsed interrogation neutron production within, or very near, an inspected object, 2) spectrum tailoring of the source neutrons, and 3) compatibility with many existing high-energy, commercial x-ray inspection devices. Basic concept feasibility was first established by numerical methods. The pulsed photoneutron inspection technique performs nondestructive elemental analysis using gamma-ray spectrometry. Highly penetrating bremsstrahlung photons are produced by a pulsed electron accelerator capable of producing up to 16-MeV electrons. The photoneutrons are generated by the bremsstrahlung photons interacting with an inspected object and near-by beryllium metal. The interactions of the neutrons within an inspected item result in the emission of elemental characteristic gamma-rays. Spectrometry is performed by analyzing the gamma -rays acquired between accelerator pulses. A unique fast detection and acquisition system, using two 5.08 x 5.08 -cm organic scintillators, acquires gamma-ray emissions within 100 ns of each accelerator pulse. The fast system is capable of processing individual gamma-ray signals at count rates up to 40 MHz between accelerator pulses with a repetition rate up to 1 kHz. The system incorporates a unique x-ray flash recovery method which allows individual gamma-ray detection as soon as 75 ns after the start of each x-ray flash occurring within the detector. Conventional detection and data acquisition systems are used to acquire gamma-ray spectra for the time period between 1000 ns and the next accelerator pulse. Operational tests using a 30-ps pulse width, electron accelerator demonstrated the x-ray flash recovery methodology, gamma-ray detection, and data acquisition. Although, gamma -ray spectrometry performance was limited by x-ray flash -induced gain shifts in

  18. Fragment Characteristics from Photofission of 234U and 238U Induced by 6.0 - 9.0 Mev Bremsstrahlung

    NASA Astrophysics Data System (ADS)

    Göök, A.; Barday, R.; Chernykh, M.; Eckardt, C.; Enders, J.; Neumann-Cosel, P. Von; Poltoratska, Y.; Wagner, M.; Richter, A.; Oberstedt, S.; Hambsch, F.-J.; Oberstedt, A.

    2011-10-01

    As a preparatory experiment for a search for parity violation in photofission, fission of 238U and 234U induced by 6 - 9 MeV bremsstrahlung has been investigated at the superconducting Darmstadt electron linear accelerator S-DALINAC. Using a twin Frisch grid ionization chamber fission fragment energy and mass distributions have been determined by means of the double kinetic energy technique. The experiment was performed in order to test the ionization chamber's performance in a bremsstrahlung environment. Results on the fission fragment characteristics from the 238U(γ,f) reaction are found to be in good agreement with literature values. In addition results on fission fragment mass and energy distributions from the 234U(γ,f) reaction are presented for the first time in this energy region.

  19. Qualitative comparison of bremsstrahlung X-rays and 800 MeV protons for tomography of urania fuel pellets

    SciTech Connect

    Morris, Christopher L.; Bourke, Mark A.; Byler, Darrin D.; Chen, Ching-Fong; Hogan, Gary E.; Hunter, James F.; Kwiatkowski, Kris K.; Mariam, Fesseha G.; McClellan, Kenneth J.; Merrill, Frank E.; Morley, Deborah J.; Saunders, Alexander

    2013-02-11

    We present an assessment of x-rays and proton tomography as tools for studying the time dependence of the development of damage in fuel rods. Also, we show data taken with existing facilities at Los Alamos National Laboratory that support this assessment. Data on surrogate fuel rods has been taken using the 800 MeV proton radiography (pRad) facility at the Los Alamos Neutron Science Center (LANSCE), and with a 450 keV bremsstrahlung X-ray tomography facility. The proton radiography pRad facility at LANSCE can provide good position resolution (<70 μm has been demonstrate, 20 μm seems feasible with minor changes) for tomography on activated fuel rods. Bremsstrahlung x-rays may be able to provide better than 100 μm resolution but further development of sources, collimation and detectors is necessary for x-rays to deal with the background radiation for tomography of activated fuel rods.

  20. Comparisons of Exact Results for the Virtual Correction to Bremsstrahlung in Electron-Positron Annihilation at High Energies

    NASA Astrophysics Data System (ADS)

    Yost, S. A.; Glosser, C.; Jadach, S.; Ward, B. F. L.

    2004-10-01

    We have compared the virtual corrections to single hard bremsstrahlung as calculated by S. Jadach, M. Melles, B.F.L. Ward and S.A. Yost to several other expressions. The most recent of these comparisons is to the leptonic tensor calculated by J.H. Kuhn and G. Rodrigo for radiative return. Agreement is found to within 10-5 or better as a fraction of the Born cross section for most of the range of photon energies.

  1. Modeling Relativistic Electron Precipitation Bremsstrahlung X-Ray Intensities at 10-100 km Manned Vehicle Altitudes

    NASA Astrophysics Data System (ADS)

    Habash Krause, L.; Gilchrist, B. E.; Nishikawa, K.; Williams, A.

    2013-12-01

    Relativistic electron precipitation (REP) events occur when beams or bunches of relativistic electrons of magnetospheric origin enter the Earth's atmosphere, typically at auroral latitudes. REP events are associated with a variety of space weather effects, including production of transitional and bremsstrahlung radiation, catalytic depletion of stratospheric ozone, and scintillation of transionospheric radio waves. This study examines the intensities of x-rays produced at airliner, manned balloon, and suborbital Reusable Launch Vehicle (sRLV) altitudes. The monoenergetic beam is modeled in cylindrical symmetry using the paraxial ray equation. Bremsstrahlung photon production is calculated using the traditional Sauter-Elwert cross-section, providing x-ray emission spectra differential in energy and angle. Attenuation is computed for a plane-stratified standard atmosphere, and the loss processes include photoionization, Rayleigh and Compton scattering, electron-positron pair production, and photonuclear interaction. Peak altitudes of electron energy deposition and bremsstrahlung x-ray production were calculated for beams of energies from 1 MeV through 100 MeV. The altitude peak of bremsstrahlung deposition was consistently and significantly lower that that of the electron deposition due to the longer mean free paths of x-rays compared to electrons within the atmosphere. For example, for a nadir-directed monoenergetic 5 MeV beam, the peak deposition altitude was calculated to be 42 km, but the resulting bremmstrahlung deposition peaked at 25 km. This has implications for crew and passenger safety, especially with the growth of the space tourism industry that relies on sRLVs with a nominal apogee of 100 km. A survey of results covering the 1-100 MeV spectrum for the three altitude ranges of interest will be presented.

  2. SU-E-E-08: Applications of the Quantization of Coupled Circuits in Radiation Physics (design of Klystron, Bremsstrahlung, Synchrotron)

    SciTech Connect

    Ulmer, W

    2015-06-15

    Purpose: During the past decade the quantization of coupled/forced electromagnetic circuits with or without Ohm’s resistance has gained the subject of some fundamental studies, since even problems of quantum electrodynamics can be solved in an elegant manner, e.g. the creation of quantized electromagnetic fields. In this communication, we shall use these principles to describe optimization procedures in the design of klystrons, synchrotron irradiation and high energy bremsstrahlung. Methods: The base is the Hamiltonian of an electromagnetic circuit and the extension to coupled circuits, which allow the study of symmetries and perturbed symmetries in a very apparent way (SU2, SU3, SU4). The introduction resistance and forced oscillators for the emission and absorption in such coupled systems provides characteristic resonance conditions, and atomic orbitals can be described by that. The extension to virtual orbitals leads to creation of bremsstrahlung, if the incident electron (velocity v nearly c) is described by a current, which is associated with its inductivitance and the virtual orbital to the charge distribution (capacitance). Coupled systems with forced oscillators can be used to amplify drastically the resonance frequencies to describe klystrons and synchrotron radiation. Results: The cross-section formula for bremsstrahlung given by the propagator method of Feynman can readily be derived. The design of klystrons and synchrotrons inclusive the radiation outcome can be described and optimized by the determination of the mutual magnetic couplings between the oscillators induced by the currents. Conclusions: The presented methods of quantization of circuits inclusive resistance provide rather a straightforward way to understand complex technical processes such as creation of bremsstrahlung or creation of radiation by klystrons and synchrotrons. They can either be used for optimization procedures and, last but not least, for pedagogical purposes with regard to

  3. A TLD-based ten channel system for the spectrometry of bremsstrahlung generated by laser-matter interaction

    NASA Astrophysics Data System (ADS)

    Horst, Felix; Fehrenbacher, Georg; Radon, Torsten; Kozlova, Ekaterina; Rosmej, Olga; Czarnecki, Damian; Schrenk, Oliver; Breckow, Joachim; Zink, Klemens

    2015-05-01

    This work presents a thermoluminescence dosimetry based method for the measurement of bremsstrahlung spectra in the energy range from 30 keV to 100 MeV, resolved in ten different energy intervals and for the photon ambient dosimetry in ultrashort pulsed radiation fields as e.g. generated during operation of the PHELIX laser at the GSI Helmholtzzentrum für Schwerionenforschung. The method is a routine-oriented development by application of a multi-filter technique. The data analysis takes around 1 h. The spectral information is obtained by the unfolding of the response of ten thermoluminescence dosimeters with absorbers of different materials and thicknesses arranged as a stack each with a different response function to photon radiation. These response functions were simulated by the use of the Monte Carlo code FLUKA. An algorithm was developed to unfold bremsstrahlung spectra from the readings of the ten dosimeters. The method has been validated by measurements at a clinical electron linear accelerator (6 MV and 18 MV bremsstrahlung). First measurements at the PHELIX laser system were carried out in December 2013 and January 2014. Spectra with photon energies up to 10 MeV and mean energies up to 420 keV were observed at laser-intensities around 1019 W /cm2 on a titanium foil target. The measurement results imply that the steel walls of the target chamber might be an additional bright x-ray source.

  4. [ital Z][sub eff] profiles measured by visible and soft x-ray bremsstrahlung arrays in TFTR (abstract)

    SciTech Connect

    Park, H.; Adler, H.; Hill, K.W. )

    1995-01-01

    The [ital Z][sub eff] profiles from the tangential array of visible bremsstrahlung (VB) emission (5235 A) have shown several interesting features in TFTR. The observed [ital Z][sub eff] profile was flat during the ohmic phase and hollow during the neutral-beam heating phase. In order to crosscheck the measured [ital Z][sub eff] profiles from the VB array, a poloidal array which measures bremsstrahlung emission in the soft x-ray region has been analyzed. The analysis of array measurements in the two different spectral regions was performed on the same geometry determined from the Abel inversion of the electron density (interferometry). The two independent measurements of [ital Z][sub eff] profiles have been consistent with each other for most of the discharges in TFTR. However, in a discharge where the two measurements are inconsistent, the [ital Z][sub eff] profile deduced from the VB array indicates some degree of problems. In this paper, the detailed analysis of the bremsstrahlung array (both poloidal and tangential) measurements is presented. Particularly, the effects of geometry in the inversion process, such as a poloidal elongation of flux surfaces, are investigated.

  5. A Figure of Merit Comparison between Bremsstrahlung and Monoenergetic X-Ray Sources for Angiography.

    PubMed

    Boone, J M; Seibert, J A

    1994-01-01

    A figure of merit (FOM) has been developed which embodies parameters related to image quality in the numerator and radiation integral dose to the patient in the denominator. In this manner, maximizing image quality and minimizing radiation dose amounts to maximizing the FOM. Furthermore, the FOM is designed to be independent of x-ray exposure (number of photons used), and this eliminates one important parameter in an optimization scenario. Monoenergetic x-ray beams (0% bandwidth) are compared with conventional Bremsstrahlung x-ray sources from a tungsten target, for angiographic imaging systems using 144 mg/cm2 Csl image intensifiers as the detector. Thus the results are applicable to both digital subtraction angiography (DSA) and digital fluoroscopic procedures involving iodine-based contrast (e.g., roadmapping). The results demonstrate improvement factors (the ratio of the best FOM of the monoenergetic beam over the best FOM of the polyenergetic beam) ranging from 2.3 to 1.4. The improvement factors averaged over four iodine contrast thicknesses (50, 100, 500, and 1000 mg/cm2) were 1.61 (σ = 0.159) for the 10 cm thick patient, 1.68 (σ= 0.172) for the 20 cm thick patient, and 1.82 (σ= 0.186) for the 30 cm thick patient. The conclusions are that monoenergetic x-ray beams are capable of delivering the same image quality at about half the radiation dose to the patient compared to conventional X-ray tubes. PMID:21307470

  6. The bremsstrahlung tagged photon beam in Hall B at the Jefferson Laboratory

    SciTech Connect

    Daniel I. Sober; Hall Crannell; Alberto Longhi; Scott Matthews; James T. O'Brien; Barry L. Berman; William Briscoe; Philip L. Cole; James Connelly; W.R. Dodge; Luc Y. Murphy; S.A. Phillips; Michael Dugger; David Lawrence; Barry G. Ritchie; Elton Smith; J.M. Lambert; Eric P.M. Anciant; Gerad Audit; Thierry Auger; Claude Marchand; Michael Klusman; James Napolitano; M.A. Khandaker; Carlos Salgado; Adam Sarty

    2000-02-01

    We describe the design and commissioning of the photon tagging beamline installed in experimental Hall B at the Thomas Jefferson National Accelerator Facility (Jlab). This system can tag photon energies over a range from 20% to 95% of the incident electron energy, and is capable of operation with beam energies up to 6.1 GeV. A single dipole magnet is combined with a hodoscope containing two planar arrays of plastic scintillators to detect energy-degraded electrons from a thin bremsstrahlung radiator. The first layer of 384 partially overlapping small scintillators provides photon energy resolution, while the second layer of 61 larger scintillators provides the timing resolution necessary to form a coincidence with the corresponding nuclear interaction triggered by the tagged photon. The definitions of overlap channels in the first counter plane and of geometric correlation between the two planes are determined using digitized time information from the individual counters. Auxiliary beamline devices are briefly described, and performance results to date under real operating conditions are presented. The entire photon-tagging system has met or exceeded its design goals.

  7. Hydramite II screening tests of potential bremsstrahlung converter debris shield materials

    SciTech Connect

    Reedy, E.D. Jr.; Hedemann, M.A.; Stark, M.A.

    1986-03-01

    Results of a brief test series aimed at screening a number of potential bremsstrahlung converter debris shield materials are reported. These tests were run on Sandia National Laboratories' Hydramite II accelerator using a diode configuration which produces a pinched electron beam. The materials tested include: (1) laminated Kevlar 49/polyester and E-glass/polyester composites, (2) a low density laminated Kevlar 49 composite, and (3) two types of through-the-thickness reinforced Kevlar 49 composites. As expected, tests using laminated Kevlar 49/polyester shields showed that shield permanent set (i.e., permanent deflection) increased with increasing tantalum conversion foil thickness and decreased with increasing shield thickness. The through-the-thickness reinforced composites developed localized, but severe, back surface damage. The laminated composites displayed little back surface damage, although extensive internal matrix cracking and ply delaminations were generated. Roughly the same degree of permanent set was produced in shields made from the low density Kevlar 49 composite and the Kevlar 49/polyester. The E-glass reinforced shields exhibited relatively low levels of permanent set.

  8. Investigation of low frequency molecular Bremsstrahlung radiation from laser induced breakdown of air

    NASA Astrophysics Data System (ADS)

    Paturi, Prem Kiran; Lakshminarayanan, Vinoth Kumar; Elle, Manikanta; Chelikani, Leela; Acrhem Team

    2015-05-01

    Low frequency electromagnetic radiation (30-1000 MHz), due to molecular Bremsstrahlung, from ns and ps laser induced breakdown (LIB) of atmospheric air is studied. In the plasma formed by the LIB of atmospheric air, interaction of charged particles with neutral clusters of atoms and molecules result in the emission of low frequency radiation. With increasing laser intensity, the plasma frequency (ωP) comes closer to the laser frequency (ωL) , leading to higher degree of ionization. This is observed to reduce the electron-neutral interactions decreasing the low frequency emissions. Thus the emissions from ps LIB are 2-3 orders smaller than those from ns LIB. While traversing from the loose to tight focusing conditions, the emissions from ns LIB and ps LIB were observed to be increasing and decreasing, respectively. This confirms the role of the number of seed electrons and their interaction with neutrals on the low frequency emissions. The emissions were observed to be spectral selective, dependent on the polarization state of the input laser pulses and the detecting antenna. The work is supported by Defence Research and Developement Organization, India through Grants-in-Aid Program.

  9. Bremsstrahlung and gamma ray lines in 3 scenarios of dark matter annihilation

    SciTech Connect

    Giacchino, Federica; Tytgat, Michel H.G.; Lopez-Honorez, Laura E-mail: llopezho@vub.ac.be

    2014-08-01

    Gamma ray spectral features are of interest for indirect searches of dark matter (DM). Following Barger et al. we consider 3 simple scenarios of DM that annihilates into Standard Model (SM) fermion pairs. Scenario 1 is a Majorana DM candidate coupled to a charged scalar, scenario 2 is a Majorana DM coupled to a charged gauge boson and scenario 3 is a real scalar DM coupled a charged vector-like fermion. As shown by Barger et al., these 3 scenarios share precisely the same internal Bremsstrahlung spectral signature into gamma rays. Their phenomenology is however distinct. In particular for annihilation into light SM fermions, in the chiral limit, the 2-body annihilation cross section is p-wave suppressed for the Majorana candidates while it is d-wave suppressed for the real scalar. In the present work we study the annihilation into 2 gammas, showing that these three scenarios have distinct, and so potentially distinguishable, spectral signatures into gamma rays. In the case of the real scalar candidate we provide a new calculation of the amplitude for annihilation into 2 gammas.

  10. Conjugate observation of electron microburst groups by Bremsstrahlung X-ray and riometer techniques

    SciTech Connect

    Siren, J.C.; Rosenberg, T.J.; Detrick, D.; Lanzerotti, L.J.

    1980-12-01

    The first evidence is reported of simultaneous conjugate electron microburst group precipitation. Groups of bremsstrahlung X ray microbursts (E>25 keV) were observed during a substorm recovery phase by a balloon-borne scintillation counter over Roberval, Quebec, Canada. The microburst groups were accompanied one-to-one by time-delayed and broadened pulses of ionospheric absorption measured by a high sensitivity 30-MHz riometer at Siple Station, Antarctica (Lapprox. =4.1). For the interval of highest correlation, the absolute lag between the two data sets was 4 +- 1 s, to the limit of the relative timing accuracy. Approximately 2 s of the observed lag had been introduces by a low-pass filter in the riometer data acquistion unit. The remainder (2 s) was due to the ionospheric recombination process, which evidently had a response time (tauapprox.5 s) during this event much shorter than that ordinarily associated with the D region of the ionosphere. Model calculations of the ionspheric response to time-varying precipitation, derived from the profile of the measurement X ray flux, provide a consistent picture of simultaneous microburst group precipitation at conjugate points, absolute absorption and the electron spectrum derived from X rays, the degree of variation in absorption and X ray fluxes, and the characteristic ionospheric time constant at the altitude of maximum energy deposition.

  11. Brain SPECT Imaging in Complex Psychiatric Cases: An Evidence-Based, Underutilized Tool

    PubMed Central

    Amen, Daniel G; Trujillo, Manuel; Newberg, Andrew; Willeumier, Kristen; Tarzwell, Robert; Wu, Joseph C; Chaitin, Barry

    2011-01-01

    Over the past 20 years brain Single Photon Emission Computed Tomography (SPECT) imaging has developed a substantial, evidence-based foundation and is now recommended by professional societies for numerous indications relevant to psychiatric practice. Unfortunately, SPECT in clinical practice is utilized by only a handful of clinicians. This article presents a rationale for a more widespread use of SPECT in clinical practice for complex cases, and includes seven clinical applications where it may help optimize patient care. PMID:21863144

  12. 99mTc-MDP SPECT/CT for assessment of condylar hyperplasia.

    PubMed

    Derlin, Thorsten; Busch, Jasmin D; Habermann, Christian R

    2013-01-01

    We report a case of condylar hyperplasia diagnosed with 99mTc-MDP SPECT/CT. A 21-year-old woman with facial asymmetry was referred for assessment of condylar growth activity. SPECT/CT confirmed condylar hyperactivity, and simultaneous low-dose CT contributed to the diagnosis of hemimandibular hyperplasia. SPECT/CT may become a valuable tool for the diagnosis and comprehensive assessment of condylar hyperplasia, providing both functional and morphological information. PMID:23242067

  13. Design and simulation of a high-resolution stationary SPECT system for small animals

    NASA Astrophysics Data System (ADS)

    Beekman, Freek J.; Vastenhouw, Brendan

    2004-10-01

    Exciting new SPECT systems can be created by combining pinhole imaging with compact high-resolution gamma cameras. These new systems are able to solve the problem of the limited sensitivity-resolution trade-off that hampers contemporary small animal SPECT. The design presented here (U-SPECT-III) uses a set of detectors placed in a polygonal configuration and a cylindrical collimator that contains 135 pinholes arranged in nine rings. Each ring contains 15 gold pinhole apertures that focus on the centre of the cylinder. A non-overlapping projection is acquired via each pinhole. Consequently, when a mouse brain is placed in the central field-of-view, each voxel in the cerebrum can be observed via 130 to 135 different pinholes simultaneously. A method for high-resolution scintillation detection is described that eliminates the depth-of-interaction problem encountered with pinhole cameras, and is expected to provide intrinsic detector resolutions better than 150 µm. By means of simulations U-SPECT-III is compared to a simulated dual pinhole SPECT (DP-SPECT) system with a pixelated array consisting of 2.0 × 2.0 mm NaI crystals. Analytic calculations indicate that the proposed U-SPECT-III system yields an almost four times higher linear and about sixty times higher volumetric system resolution than DP-SPECT, when the systems are compared at matching system sensitivity. In addition, it should be possible to achieve a 15 up to 30 times higher sensitivity with U-SPECT-III when the systems are compared at equal resolution. Simulated images of a digital mouse-brain phantom show much more detail with U-SPECT-III than with DP-SPECT. In a resolution phantom, 0.3 mm diameter cold rods are clearly visible with U-SPECT-III, whereas with DP-SPECT the smallest visible rods are about 0.6-0.8 mm. Furthermore, with U-SPECT-III, the image deformations outside the central plane of reconstruction that hamper conventional pinhole SPECT are strongly suppressed. Simulation results indicate

  14. Prone breast tumor imaging using vertical axis-of-rotation (VAOR) SPECT systems: An initial study

    SciTech Connect

    Wang, Huili; Scarfone, C.; Greer, K.L.; Coleman, R.E.

    1996-12-31

    We propose the use of a single photon emission computed tomography (SPECT) system equipped with multiple cameras revolving around a vertical axis-of-rotation (VAOR) to image tumors in a prone-dependent breast. This innovative breast imaging approach has the advantages of a small attenuation volume between breast lesions and gamma detector as well as a minimal radius-of-rotation compared to conventional (horizontal axis-of-rotation) breast SPECT. Small attenuation volume results in improved detected counts and minimal radius-of-rotation leads to increased collimator resolution. Because of no VAOR SPECT system currently available, we conducted our experiments on a conventional SPECT system using an isolated breast phantom to investigate the proposed VAOR breast SPECT. Our experimental setup simulated a VAOR SPECT study with a prone-dependent breast in the camera`s field-of-view. The results of our experiment indicate that VAOR breast SPECT with Trionix LESR parallel hole collimator is capable of detecting a breast lesion with a diameter of 10 mm and a lesion-to-background concentration ratio of 6 to 1. The results also demonstrate that VAOR breast SPECT provides improved lesion visualization over planar scintimammography and conventional breast SPECT.

  15. EANM procedural guidelines for radionuclide myocardial perfusion imaging with SPECT and SPECT/CT: 2015 revision.

    PubMed

    Verberne, Hein J; Acampa, Wanda; Anagnostopoulos, Constantinos; Ballinger, Jim; Bengel, Frank; De Bondt, Pieter; Buechel, Ronny R; Cuocolo, Alberto; van Eck-Smit, Berthe L F; Flotats, Albert; Hacker, Marcus; Hindorf, Cecilia; Kaufmann, Philip A; Lindner, Oliver; Ljungberg, Michael; Lonsdale, Markus; Manrique, Alain; Minarik, David; Scholte, Arthur J H A; Slart, Riemer H J A; Trägårdh, Elin; de Wit, Tim C; Hesse, Birger

    2015-11-01

    Since the publication of the European Association of Nuclear Medicine (EANM) procedural guidelines for radionuclide myocardial perfusion imaging (MPI) in 2005, many small and some larger steps of progress have been made, improving MPI procedures. In this paper, the major changes from the updated 2015 procedural guidelines are highlighted, focusing on the important changes related to new instrumentation with improved image information and the possibility to reduce radiation exposure, which is further discussed in relation to the recent developments of new International Commission on Radiological Protection (ICRP) models. Introduction of the selective coronary vasodilator regadenoson and the use of coronary CT-contrast agents for hybrid imaging with SPECT/CT angiography are other important areas for nuclear cardiology that were not included in the previous guidelines. A large number of minor changes have been described in more detail in the fully revised version available at the EANM home page: http://eanm.org/publications/guidelines/2015_07_EANM_FINAL_myocardial_perfusion_guideline.pdf . PMID:26290421

  16. First Robotic SPECT for Minimally Invasive Sentinel Lymph Node Mapping.

    PubMed

    Fuerst, Bernhard; Sprung, Julian; Pinto, Francisco; Frisch, Benjamin; Wendler, Thomas; Simon, Hervé; Mengus, Laurent; van den Berg, Nynke S; van der Poel, Henk G; van Leeuwen, Fijs W B; Navab, Nassir

    2016-03-01

    In this paper we present the usage of a drop-in gamma probe for intra-operative Single-Photon Emission Computed Tomography (SPECT) imaging in the scope of minimally invasive robot-assisted interventions. The probe is designed to be inserted and reside inside the abdominal cavity during the intervention. It is grasped during the procedure using a robotic laparoscopic gripper enabling full six degrees of freedom handling by the surgeon. We demonstrate the first deployment of the tracked probe for intra-operative in-patient robotic SPECT enabling augmented-reality image guidance. The hybrid mechanical- and image-based in-patient probe tracking is shown to have an accuracy of 0.2 mm. The overall system performance is evaluated and tested with a phantom for gynecological sentinel lymph node interventions and compared to ground-truth data yielding a mean reconstruction accuracy of 0.67 mm. PMID:26561283

  17. Dual-radiolabeled nanoparticle SPECT probes for bioimaging

    NASA Astrophysics Data System (ADS)

    Black, Kvar C. L.; Akers, Walter J.; Sudlow, Gail; Xu, Baogang; Laforest, Richard; Achilefu, Samuel

    2014-12-01

    A gold nanoparticle was radiolabeled with 125I and 111In and functionalized with an MMP9-cleavable peptide to form a multispectral SPECT imaging contrast agent. Peptide cleavage from the nanoprobe by MMP9 was observed in vitro, and distinct pharmacokinetic properties of the contrast agent were observed between tumors with high or low MMP9 expression.A gold nanoparticle was radiolabeled with 125I and 111In and functionalized with an MMP9-cleavable peptide to form a multispectral SPECT imaging contrast agent. Peptide cleavage from the nanoprobe by MMP9 was observed in vitro, and distinct pharmacokinetic properties of the contrast agent were observed between tumors with high or low MMP9 expression. Electronic supplementary information (ESI) available. See DOI: 10.1039/c4nr05269b

  18. A novel SPECT camera for molecular imaging of the prostate

    NASA Astrophysics Data System (ADS)

    Cebula, Alan; Gilland, David; Su, Li-Ming; Wagenaar, Douglas; Bahadori, Amir

    2011-10-01

    The objective of this work is to develop an improved SPECT camera for dedicated prostate imaging. Complementing the recent advancements in agents for molecular prostate imaging, this device has the potential to assist in distinguishing benign from aggressive cancers, to improve site-specific localization of cancer, to improve accuracy of needle-guided prostate biopsy of cancer sites, and to aid in focal therapy procedures such as cryotherapy and radiation. Theoretical calculations show that the spatial resolution/detection sensitivity of the proposed SPECT camera can rival or exceed 3D PET and further signal-to-noise advantage is attained with the better energy resolution of the CZT modules. Based on photon transport simulation studies, the system has a reconstructed spatial resolution of 4.8 mm with a sensitivity of 0.0001. Reconstruction of a simulated prostate distribution demonstrates the focal imaging capability of the system.

  19. SPECT study of regional cerebral blood flow in Alzheimer disease

    SciTech Connect

    Bonte, F.J.; Ross, E.D.; Chehabi, H.H.; Devous, M.D. Sr.

    1986-07-01

    A common cause of dementia in late midlife and old age is Alzheimer disease (AD), which affects more than one in 20 individuals over the age of 65. Past studies of regional cerebral blood flow (rCBF) in patients with AD here suggested blood flow abnormalities, but findings have differed. We have studied 37 patients diagnosed as having AD with inhalation and washout of /sup 133/Xe and single-photon emission computed tomography (SPECT), obtaining evidence of abnormal rCBF patterns in 19. Flow reductions were most common in the temporoparietal regions and were occasionally found in the frontal areas. Investigators using positron-emission tomography (PET) have identified similar findings with respect to rCBF and regional oxygen, glucose, and protein metabolism. The SPECT determination of rCBF, which gives information similar to that provided by PET, may assume importance in the diagnosis of AD and in the differential diagnosis of the dementias.

  20. Infective endocarditis detection through SPECT/CT images digital processing

    NASA Astrophysics Data System (ADS)

    Moreno, Albino; Valdés, Raquel; Jiménez, Luis; Vallejo, Enrique; Hernández, Salvador; Soto, Gabriel

    2014-03-01

    Infective endocarditis (IE) is a difficult-to-diagnose pathology, since its manifestation in patients is highly variable. In this work, it was proposed a semiautomatic algorithm based on SPECT images digital processing for the detection of IE using a CT images volume as a spatial reference. The heart/lung rate was calculated using the SPECT images information. There were no statistically significant differences between the heart/lung rates values of a group of patients diagnosed with IE (2.62+/-0.47) and a group of healthy or control subjects (2.84+/-0.68). However, it is necessary to increase the study sample of both the individuals diagnosed with IE and the control group subjects, as well as to improve the images quality.

  1. Recent advances in cardiac SPECT instrumentation and system design.

    PubMed

    Smith, Mark F

    2013-08-01

    Recent advances in clinical cardiac SPECT instrumentation are reviewed from a systems perspective. New hardware technologies include pixelated scintillator and semiconductor detector elements; photodetectors such as position-sensitive photomultiplier tubes (PSPMT), avalanche photodiodes (APD) and silicon photomultipliers (SiPM); and novel cardiac collimation methods. There are new approaches for positioning detectors and controlling their motion during cardiac imaging. Software technology advances include iterative image reconstruction with modeling of Poisson statistics and depth-dependent collimator response. These new technologies enable faster acquisitions, the lowering of administered activity and radiation dose, and improved image resolution. Higher sensitivity collimators are a significant factor enabling faster acquisitions. Several clinical systems incorporating new technologies are discussed and different system designs can achieve similar performance. With detector elements such as APDs, SiPMs and semiconductors that are insensitive to magnetic fields, the potential for cardiac SPECT imagers that are MRI compatible opens up new frontiers in clinical cardiac research and patient care. PMID:23832650

  2. Bone Scintigraphy SPECT/CT Evaluation of Mandibular Condylar Hyperplasia.

    PubMed

    Yang, Zhiyun; Reed, Tameron; Longino, Becky H

    2016-03-01

    Mandibular condylar hyperplasia (CH) is a complex developmental deformity resulting in asymmetries of the hyperplastic condyle. Bone scan SPECT is a sensitive and accurate method of detecting the growth activity of this disorder. This method can be used to quantitate the radionuclide uptake differences between the left and right condyles. Uptake differences of 10% or more between the left and right condyles, with increased uptake ipsilateral to the CH, are considered to be evidence of active growing CH. Quantitative assessment of CH is important to select an appropriate treatment course. Degenerative arthropathies of the temporomandibular joints may result in altered uptake, but this is mostly associated with the side contralateral to the CH. The CT portion of SPECT/CT is useful to assess the condylar dimensions and underlying bony changes. PMID:26111714

  3. Accuracy of quantitative reconstructions in SPECT/CT imaging

    NASA Astrophysics Data System (ADS)

    Shcherbinin, S.; Celler, A.; Belhocine, T.; van der Werf, R.; Driedger, A.

    2008-09-01

    The goal of this study was to determine the quantitative accuracy of our OSEM-APDI reconstruction method based on SPECT/CT imaging for Tc-99m, In-111, I-123, and I-131 isotopes. Phantom studies were performed on a SPECT/low-dose multislice CT system (Infinia-Hawkeye-4 slice, GE Healthcare) using clinical acquisition protocols. Two radioactive sources were centrally and peripherally placed inside an anthropometric Thorax phantom filled with non-radioactive water. Corrections for attenuation, scatter, collimator blurring and collimator septal penetration were applied and their contribution to the overall accuracy of the reconstruction was evaluated. Reconstruction with the most comprehensive set of corrections resulted in activity estimation with error levels of 3-5% for all the isotopes.

  4. Dual-headed SPECT for awake animal brain imaging

    SciTech Connect

    Lee, Seung Joon; Weisenberger, A G; McKisson, J; Goddard Jr, James Samuel; Baba, Justin S; Smith, M F

    2011-01-01

    Abstract- Motion-corrected awake animal imaging is needed for normal-state investigations of models of neurological disease and brain activity. The awake animal brain SPECT/CT system, AwakeSPECT at Johns Hopkins University has in the past used a single gamma camera for imaging. Enhancements have been made by adding a pinhole collimator to the second gamma camera at the opposite side which has been previously equipped parallel hole collimator. Geometry calibration was performed using a custom built quality control phantom containing three Co-57 point sources and applied to the tomographic reconstruction code. Hot-rod phantom scans with Tc-99m were performed to test sensitivity and resolution improvements. The reconstruction results show significant resolution and sensitivity improvements.

  5. Dual-headed SPECT for awake animal brain imaging

    SciTech Connect

    S. Lee, B. Kross, D. Weisenberger, J. McKisson, J.S. Goddard, J.S. Baba, M.S. Smith

    2012-02-01

    Motion-corrected awake animal imaging is needed for normal-state investigations of models of neurological disease and brain activity. The awake animal brain SPECT/CT system, AwakeSPECT at Johns Hopkins University has in the past used a single gamma camera for imaging. Enhancements have been made by adding a pinhole collimator to the second gamma camera at the opposite side which has been previously equipped parallel hole collimator. Geometry calibration was performed using a custom built quality control phantom containing three Co-57 point sources and applied to the tomographic reconstruction code. Hot-rod phantom scans with Tc-99m were performed to test sensitivity and resolution improvements. The reconstruction results show significant resolution and sensitivity improvements.

  6. Os trigonum syndrome on bone SPECT/CT.

    PubMed

    Huang, Jianmin; Servaes, Sabah; Zhuang, Hongming

    2014-08-01

    A 16-year-old female athlete presented with increased pain in the distal left lower extremity. A possible stress fracture or shin splint of the left tibia was first considered. A 3-phase bone scintigraphy showed a very small focus of increased activity in the posterior left foot. A diagnosis of os trigonum syndrome was made after SPECT/CT images pinpointed the activity at the left os trigonum. PMID:24686218

  7. Fast SPECT simulation including object shape dependent scatter.

    PubMed

    Beekman, F J; Viergever, M A

    1995-01-01

    A fast simulator of SPECT projection data taking into account attenuation, distance dependent detector response, and scatter has been developed, based on an analytical point spread function model. The parameters of the scatter response are obtained from a single line source measurement with a triangular phantom. The simulator is able to include effects of object curvature on the scatter response to a high accuracy. The simulator has been evaluated for homogeneous media by measurements of (99m)Tc point sources placed at different locations in a water-filled cylinder at energy windows of 15% and 20%. The asymmetrical shapes of measured projections of point sources are In excellent agreement with simulations for both energy windows. Scatter-to-primary ratio (SPR) calculations of point sources at different positions in a cylindrical phantom differ not more than a few percent from measurements. The simulator uses just a few megabytes of memory for storing the tables representing the forward model; furthermore, simulation of 60 SPECT projections from a three-dimensional digital brain phantom with 6-mm cubic voxels takes only ten minutes on a standard workstation. Therefore, the simulator could serve as a projector in iterative true 3-D SPECT reconstruction. PMID:18215831

  8. Fast SPECT simulation including object shape dependent scatter

    SciTech Connect

    Beekman, F.J.; Viergever, M.A.

    1995-06-01

    A fast simulator of SPECT projection data taking into account attenuation, distance dependent detector response, and scatter has been developed, based on an analytical point spread function model. The parameters of the scatter response are obtained from a single line source measurement with a triangular phantom. The simulator is able to include effects of object curvature on the scatter responses to a high accuracy. The simulator has been evaluated for homogeneous media by measurements of {sup 99m}Tc point sources placed at different locations in a water-filled cylinder at energy windows of 15% and 20%. The asymmetrical shapes of measured projections of point sources are in excellent agreement with simulations for both energy windows. Scatter-to-primary ratio (SPR) calculations of point sources at different positions in a cylindrical phantom differ not more than a few percent from measurements. The simulator uses just a few megabytes of memory for storing the tables representing the forward model; furthermore, simulation of 60 SPECT projections from a three-dimensional digital brain phantom with 6-mm cubic voxels takes only ten minutes on a standard workstation. Therefore, the simulator could serve as a projector in iterative true 3-D SPECT reconstruction.

  9. Dynamic heart-in-thorax phantom for functional SPECT

    SciTech Connect

    Celler, A.; Lyster, D.; Farncombe, T.

    1996-12-31

    We have designed and built a dynamic heart-in-thorax phantom to be used as a primary tool during the experimental verification of the performance of the quantitative dynamic functional imaging method we are developing for standard rotating single photon emission computed tomography (SPECT) cameras. The phantom consists of two independent parts (i) a dynamic heart model with the possibility of mounting {open_quotes}defects{close_quotes} inside it and (ii) a non-uniform thorax model with lungs and spinal cord, and uses the fact that the washout of a tracer by dilution is governed by a linear first order equation, the same type of equation as is used to model time-activity distribution in myocardial viability studies. Tests of the dynamic performance of the phantom in planar scanning mode have confirmed the validity of these assumptions. Also the preliminary results obtained in SPECT mode show that the values of characteristic times could be experimentally determined and that these values agreed well with the values preset on the phantom. We consider that the phantom is ready for extensive use in studies into development of the dynamic SPECT method.

  10. SPECT-PET in Epilepsy and Clinical Approach in Evaluation.

    PubMed

    Ergün, Eser Lay; Saygi, Serap; Yalnizoglu, Dilek; Oguz, Kader Karli; Erbas, Belkis

    2016-07-01

    In epilepsy, a detailed history, blood chemistry, routine electroencephalography, and brain MRI are important for the diagnosis of seizure type or epilepsy syndrome for the decision of appropriate drug treatment. Although antiepileptic drugs are mostly successful for controlling epileptic seizures, 20%-30% patients are resistant to medical treatment and continue to have seizures. In this intractable patient group, surgical resection is the primarily preferred treatment option. This particular group of patients should be referred to the epilepsy center for detailed investigation and further treatment. When the results of electroencephalography, MRI, and clinical status are discordant or there is no structural lesion on MRI, ictal-periictal SPECT, and interictal PET play key roles for lateralization or localization of epileptic region and guidance for the subsequent subdural electrode placement in intractable epilepsy. SPECT and PET show the functional status of the brain. SPECT and PET play important roles in the evaluation of epilepsy sydromes in childhood by showing abnormal brain regions. Most of the experience has been gained with (18)FDG-PET, in this respect. (11)C-flumazenil-PET usually deliniates the seizure focus more smaller than (18)FDG-PET and is sensitive in identifying medial temporal sclerosis. (11)C-alpha-methyl-l-tryptophan is helpful in the differentiation of epileptogenic and nonepileptogenic regions in children especially in tuberous sclerosis and multifocal cortical dysplasia for the evaluation of surgery. Finally, when there is concordance among these detailed investigations, resective surgery or palliative procedures can be discussed individually. PMID:27237440

  11. Compact CT/SPECT Small-Animal Imaging System

    PubMed Central

    Kastis, George A.; Furenlid, Lars R.; Wilson, Donald W.; Peterson, Todd E.; Barber, H. Bradford; Barrett, Harrison H.

    2015-01-01

    We have developed a dual-modality CT/SPECT imaging system for small-animal imaging applications. The X-ray system comprises a commercially available micro-focus X-ray tube and a CCD-based X-ray camera. X-ray transmission measurements are performed based on cone-beam geometry. Individual projections are acquired by rotating the animal about a vertical axis in front of the CCD detector. A high-resolution CT image is obtained after reconstruction using an ordered subsets-expectation maximization (OS-EM) reconstruction algorithm. The SPECT system utilizes a compact semiconductor camera module previously developed in our group. The module is mounted perpendicular to the X-ray tube/CCD combination. It consists of a 64×64 pixellated CdZnTe detector and a parallel-hole tungsten collimator. The field of view is 1 square inch. Planar projections for SPECT reconstruction are obtained by rotating the animal in front of the detector. Gamma-ray and X-ray images are presented of phantoms and mice. Procedures for merging the anatomical and functional images are discussed. PMID:26538684

  12. SPECT-CT system for small animal imaging

    SciTech Connect

    Andrew Weisenberger; Randolph Wojcik; E.L. Bradley; Paul Brewer; Stanislaw Majewski; Jianguo Qian; Amoreena Ranck; Arunava Saha; Mark Smith; Robert Welsh

    2003-02-01

    The Detector Group at the Thomas Jefferson National Accelerator Facility (Jefferson Lab) and the Biology, Physics, and Applied Sciences Departments at the College of William and Mary are collaborating on the development of a miniature dual modality SPECT-CT system for mouse imaging. The detector heads of the SPECT sub-system are designed to be capable of imaging the gamma- and X-ray emissions (28-35 keV) of the radioactive isotope iodine-125 (I-125). Two different sets of I-125 imaging detectors are configured on a gantry that has an open-barrel type design. One set of detector heads is based on the 1-in square Hamamatsu R5900-M64 position sensitive photomultiplier tube coupled to crystal scintillator arrays. The other detector heads configured on the gantry are two 5-in diameter Hamamatsu R3292-based compact gamma cameras. The X-ray radiographic projections are obtained using a LIXI Inc. model LF-85-503-OS X-ray imaging system that has an active area of 5.5 cm in diameter. The open-barrel shaped gantry facilitates the positioning of various mini gamma-ray imaging detectors and the X-ray system. The data acquisition and gantry control is interfaced through a Macintosh G3 workstation. Preliminary SPECT reconstruction results using the R5900 based detector are presented.

  13. SPECT-CT System for Small Animal Imaging

    SciTech Connect

    A.G. Weisenberger; R. Wojcik; E.L. Bradley; P. Brewer; S. Majewski; J. Qian; A. Ranck; M.S. Saha; K. Smith; M.F. Smith; R.E. Welsh

    2001-11-01

    The Detector Group at the Thomas Jefferson National Accelerator Facility (Jefferson Lab) and the Biology, Physics and Applied Sciences Departments at the College of William and Mary are collaborating on the development of a miniature dual modality SPECT-CT system for mouse imaging. The detector heads of the SPECT sub-system are capable of imaging the gamma- and x-ray emissions (28-35 keV) of the radioactive isotope iodine-125 (I-125). Two different sets of I-125 imaging detectors are configured on a gantry which has an open-barrel type design. One set of detector heads is based on the 1 inch square Hamamatsu R5900-M64 position sensitive photomultiplier tube coupled to crystal scintillator arrays. The other detector heads configured on the gantry are two 5-inch diameter Hamamatsu R3292-based compact gamma cameras. The x-ray radiographic projections will be obtained using a LIXI Inc. model LF-85-503-OS x-ray imaging system that has an active area of 5.5 cm in diameter. The open-barrel shaped gantry facilitates the positioning of various mini gamma-ray imaging detectors and the x-ray system. The data acquisition and gantry control is interfaced through a Macintosh G3 workstation. SPECT reconstruction results using the R5900 based detector are presented.

  14. Physiological imaging with PET and SPECT in Dementia

    SciTech Connect

    Jagust, W.J. . Dept. of Neurology Lawrence Berkeley Lab., CA )

    1989-10-01

    Dementia is a medical problem of increasingly obvious importance. The most common cause of dementia, Alzheimer's disease (AD) accounts for at least 50% of all cases of dementia, with multi-infarct dementia the next most common cause of the syndrome. While the accuracy of diagnosis of AD may range from 80 to 90%, there is currently no laboratory test to confirm the diagnosis. Functional imaging techniques such as positron emission tomography (PET) and single photon emission computed tomography (SPECT) offer diagnostic advantages since brain function is unequivocally disturbed in all dementing illnesses. Both PET and SPECT have been utilized in the study of dementia. While both techniques rely on principles of emission tomography to produce three dimensional maps of injected radiotracers, the differences between positron and single photon emission have important consequences for the practical applications of the two procedures. This briefly reviews the technical differences between PET and SPECT, and discusses how both techniques have been used in our laboratory to elucidate the pathophysiology of dementia. 32 refs., 2 figs.

  15. Determination of Endpoint Energy and Bremsstrahlung Spectra for High-Energy Radiation-Therapy Beams

    NASA Astrophysics Data System (ADS)

    Landry, Danny Joe

    Few attempts have been made to experimentally determine thick-target bremsstrahlung spectra of megavoltage therapy beams. For spectral studies using the Compton scattering technique, sodium iodine (NaI) detectors with relatively poor energy resolution have been used. Other experimental techniques for determining spectra are generally not suited for a clinical environment with the inherent time and space constraints. To gather more spectral information than previously obtained in the region near the endpoint energy, the use of a high-resolution intrinsic-germanium (Ge) detector was proposed. A response function matrix was determined from experimentally obtained pulse height distributions on the multichannel analyzer. The distributions were for nine various monoenergetic sources between 280 adn 1525 keV. The response function was used to convert the measured pulse height distributions to photon flux spectra using an iterative approximation technique with a computer. Photon flux spectra from the Sagittaire Linear Accelerator were obtained at average-electron endpoint energies of 15, 20, and 25 MeV. Two spectra were measured at the 25 MeV setting; one spectrum was measured along the central axis and one spectrum at 4(DEGREES) off axis. Photon spectra were also obtained for a Van de Graaff generator at the nominal endpoint energies of 2.2, 2.35, and 2.5 MeV. The results for both the linac and the Van de Graaff generator were compared with theoretical spectra and previously measured spectra where available. Also, photon spectra from a Theratron-80 (('60)Co) unit were determined for three field sizes and for a 10 x 10 cm. field with a lucite tray or a 45(DEGREES) wedge in the beam. The resulting spectra were compared to previously measured ('60)Co spectra.

  16. Spatially resolved hard X-ray polarization in solar flares: effects of Compton scattering and bremsstrahlung

    NASA Astrophysics Data System (ADS)

    Jeffrey, N. L. S.; Kontar, E. P.

    2011-12-01

    Aims: We study the polarization of hard X-ray (HXR) sources in the solar atmosphere, including Compton backscattering of photons in the photosphere (the albedo effect) and the spatial distribution of polarization across the source. Methods: HXR photon polarization and spectra produced via electron-ion bremsstrahlung emission are calculated from various electron distributions typical for solar flares. Compton scattering and photoelectric absorption are then modelled using Monte Carlo simulations of photon transport in the photosphere to study the observed (primary and albedo) sources. Polarization maps across HXR sources (primary and albedo components) for each of the modelled electron distributions are calculated at various source locations from the solar centre to the limb. Results: We show that Compton scattering produces a distinct polarization variation across the albedo patch at peak albedo energies of 20-50 keV for all anisotropies modelled. The results show that there are distinct spatial polarization changes in both the radial and perpendicular to radial directions across the extent of the HXR source at a given disk location. In the radial direction, the polarization magnitude and direction at specific positions along the HXR source will either increase or decrease with increased photon distribution directivity towards the photosphere. We also show how high electron cutoff energies influence the direction of polarization at above ~100 keV. Conclusions: Spatially resolved HXR polarization measurements can provide important information about the directivity and energetics of the electron distribution. Our results indicate the preferred angular resolution of polarization measurements required to distinguish between the scattered and primary components. We also show how spatially resolved polarization measurements could be used to probe the emission pattern of an HXR source, using both the magnitude and the direction of the polarization.

  17. Inverse bremsstrahlung heating rate in xenon clusters in the eikonal approximation

    NASA Astrophysics Data System (ADS)

    Dey, R.; Roy, A. C.

    2013-03-01

    We report inverse bremsstrahlung (IB) heating rates in the eikonal approximation (EA). The present analysis is performed using the plasma-screened Rogers and Debye potentials for Xe clusters with two different charge states (6 and 10). We compare the eikonal results with the first Born approximation (FBA) and classical-simulation (CL-sim) (Moll et al., Phys. Plasmas 19, 033303 (2012)) calculations for clusters in infrared light. Calculations have been performed for the field strength of 2.6 × 108 V/cm. We find that compared to the FBA and CL-sim methods, the IB heating rate in the EA is less sensitive to the choice of the two potentials considered here. The present EA calculation shows that the influence of the inner structure of atomic ion on the heating rate is more prominent for the smaller ion charge (Xe6+). In the case of low laser field approximation based on the elastic transport cross sections, it is seen that in contrast to the FBA and classical methods, the heating rate predicted by the EA does not deviate much all over the range of mean kinetic energy of electrons (20-500 eV) considered here for both the charge states of xenon (Xe6+ and Xe10+). Furthermore, for the Rogers potential, EA is found to be in closer agreement with the classical method than the FBA. We also compare the results of the IB heating rate using the present and low-field approximation approaches to the above three methods and observe that the magnitudes of the IB heating rate calculated in the low field approximation are, in general, higher than the corresponding values predicted by the present approach for both the electron-ion potentials.

  18. Direction-dependent localization errors in SPECT images

    SciTech Connect

    Roper, Justin; Bowsher, James; Yin Fangfang

    2010-09-15

    Purpose: Single photon emission computed tomography (SPECT) is being investigated for imaging inside radiation therapy treatment rooms to localize biological targets. Here, computer simulations were used to analyze locational and directional dependencies in localization errors and to assess the effects of spatial resolution modeling and observer normalization on localization performance. Methods: SPECT images of the XCAT phantom, containing 12 hot tumors, were reconstructed with detector response function compensation (DRC) and without DRC (nDRC). Numerical observers were forced to select the most suspicious tumor location, using normalized cross correlation (NXC) or un-normalized cross correlation (XC), from 3 cm diameter search volumes that each contained only one tumor. For each tumor site, localization was optimized as a function of the iteration number and postreconstruction smoothing. Localization error, the distance between true and estimated tumor positions, was calculated across the ensembles of 80 images. Direction-dependent localization bias and precision were estimated from the image ensemble. Results: For the six superficial tumors in close proximity to the detector trajectory, mean localization errors were <2 mm and were lowest or comparable using DRC-NXC, though differences from DRC-XC and nDRC-NXC were not statistically significant. DRC-NXC did provide statistically significantly better localization than nDRC-XC for five of these six tumors. At the other six sites where attenuation was more severe and the distance was generally greater between the tumor and detector, DRC typically did not show better localization than nDRC. Observer normalization improved the localization substantially for a tumor near the hotter heart. Localization errors were anisotropic and dependent on tumor location relative to the detector trajectory. Conclusions: This computer-simulation study compared localization performance for normalized and un-normalized numerical

  19. A parallel Monte Carlo code for planar and SPECT imaging: implementation, verification and applications in 131I SPECT

    PubMed Central

    Dewaraja, Yuni K.; Ljungberg, Michael; Majumdar, Amitava; Bose, Abhijit; Koral, Kenneth F.

    2009-01-01

    This paper reports the implementation of the SIMIND Monte Carlo code on an IBM SP2 distributed memory parallel computer. Basic aspects of running Monte Carlo particle transport calculations on parallel architectures are described. Our parallelization is based on equally partitioning photons among the processors and uses the Message Passing Interface (MPI) library for interprocessor communication and the Scalable Parallel Random Number Generator (SPRNG) to generate uncorrelated random number streams. These parallelization techniques are also applicable to other distributed memory architectures. A linear increase in computing speed with the number of processors is demonstrated for up to 32 processors. This speed-up is especially significant in Single Photon Emission Computed Tomography (SPECT) simulations involving higher energy photon emitters, where explicit modeling of the phantom and collimator is required. For 131I, the accuracy of the parallel code is demonstrated by comparing simulated and experimental SPECT images from a heart/thorax phantom. Clinically realistic SPECT simulations using the voxel-man phantom are carried out to assess scatter and attenuation correction. PMID:11809318

  20. First-line treatment with rituximab-hyperCVAD alternating with rituximab-methotrexate-cytarabine and followed by consolidation with 90Y-ibritumomab-tiuxetan in patients with mantle cell lymphoma. Results of a multicenter, phase 2 pilot trial from the GELTAMO group

    PubMed Central

    Arranz, Reyes; García-Noblejas, Ana; Grande, Carlos; Cannata-Ortiz, Jimena; Sánchez, José J.; García-Marco, José-Antonio; Aláez, Concepción; Pérez-Calvo, Javier; Martínez-Sánchez, Pilar; Sánchez-González, Blanca; Canales, Miguel-Angel; Conde, Eulogio; Martín, Alejandro; Arranz, Eva; Terol, María-José; Salar, Antonio; Caballero, Dolores

    2013-01-01

    The prognosis for fit patients with mantle cell lymphoma has improved with intensive strategies. Currently, the role of maintenance/consolidation approaches is being tested as relapses continue to appear. In this trial we evaluated the feasibility, safety and efficacy of rituximab-hyperCVAD alternating with rituximab-methotrexate-cytarabine followed by consolidation with 90Y-ibritumomab tiuxetan. Patients received six cycles followed by a single dose of 90Y-ibritumomab tiuxetan. Thirty patients were enrolled; their median age was 59 years. Twenty-four patients finished the induction treatment, 23 achieved complete remission (77%, 95% confidence interval 60–93) and one patient had progressive disease (3%). Eighteen patients (60%), all in complete remission, received consolidation therapy. In the intent-to-treat population, failure-free, progression-free and overall survival rates at 4 years were 40% (95% confidence interval 20.4–59.6), 52% (95% confidence interval 32.4–71.6) and 81% (95% confidence interval 67.28–94.72), respectively. For patients who received consolidation, failure-free and overall survival rates were 55% (95% confidence interval 31.48–78.52) and 87% (95% confidence interval 70–100), respectively. Hematologic toxicity was significant during induction and responsible for one death (3.3%). After consolidation, grade 3–4 neutropenia and thrombocytopenia were observed in 72% and 83% of patients, with a median duration of 5 and 12 weeks, respectively. Six (20%) patients died, three due to secondary malignancies (myelodysplastic syndrome and bladder and rectum carcinomas). In conclusion, in our experience, rituximab-hyperCVAD alternated with rituximab-methotrexate-cytarabine and followed by consolidation with 90Y-ibritumomab tiuxetan was efficacious although less feasible than expected. The unacceptable toxicity observed, especially secondary malignancies, advise against the use of this strategy. Trial registration: clinical.gov identifier

  1. Distinction between hemangioma of the liver and hepatocellular carcinoma: value of labeled RBC-SPECT scanning

    SciTech Connect

    Kudo, M.; Ikekubo, K.; Yamamoto, K.; Ibuki, Y.; Hino, M.; Tomita, S.; Komori, H.; Orino, A.; Todo, A.

    1989-05-01

    The role of adding single-photon emission CT (SPECT) to /sup 99m/Tc-labeled RBC imaging of the liver was evaluated by specifically focusing on the differentiation between hepatic hemangioma and hepatocellular carcinoma. Planar RBC imaging followed by blood-pool SPECT scanning was performed in 77 patients with a total of 108 hemangiomas and in 29 patients with a total of 46 hepatocellular carcinomas. All lesions were smaller than 5 cm in diameter. Thirty-six (33%) of 108 hemangiomas were detected by planar delayed RBC imaging, whereas 63 (58%) were detected by the delayed RBC-SPECT scan. The smallest hemangioma shown by delayed RBC-SPECT scanning was 1.4 cm in diameter, compared with 1.7 cm by planar RBC scanning. When confined to nodules larger than 1.4 cm in diameter, 42% of hemangiomas (36/85) were detected by planar delayed RBC imaging, whereas 74% (63/85) were detected by delayed RBC-SPECT. Increase in sensitivity was noted in nodules 2.1-4.0 cm in diameter. No hepatocellular carcinomas were shown by delayed RBC planar or SPECT scans. We concluded that with the addition of SPECT, the sensitivity of delayed RBC scans in the detection of small hemangiomas is considerably improved. Delayed RBC-SPECT scanning can be used to distinguish hemangioma from hepatocellular carcinoma.

  2. Evaluation of the Effect of Attenuation Correction by External CT in a Semiconductor SPECT.

    PubMed

    Uchibe, Taku; Miyai, Masahiro; Yata, Nobuhiro; Haramoto, Masuo; Yamamoto, Yasushi; Nakamura, Megumi; Kitagaki, Hajime; Takahashi, Yasuyuki

    2016-07-01

    The discovery of NM530c with a cadmium-zinc-telluride detector (CdZnTe-SPECT) is superior to the conventional Anger-type SPECT with a sodium-iodide detector (NaI-SPECT) in terms of sensitivity and spatial resolution. However, in the clinical example, even in CdZnTe-SPECT, a count decrease in myocardium due to the attenuation of the gamma ray is an issue. This study was conducted to evaluate the effect of computed tomography attenuation correction (CTAC) in CdZnTe-SPECT with the help of external CT. We evaluated the revision effect of uniformity, influence by the difference in attenuation distance, contrast ratio, an uptake rate using the heart phantom. As a result of the phantom studies, a good revision effect was obtained. In the clinical study, there was a statistical significant difference between the contrast ratio before and after CTAC in the inferior wall. In addition, the contrast ratio before and after CTAC in CdZnTe-SPECT image was equal to those of NaI-SPECT image. It was suggested that CTAC using external CT in CdZnTe-SPECT was clinically useful for inferior wall. PMID:27440705

  3. SPECT assay of radiolabeled monoclonal antibodies. Final performance report, March 1992--November 1995

    SciTech Connect

    Jaszczak, R.J.

    1995-12-01

    Research is described in the following areas: development and evaluation quantitatively of reconstruction algorithms with improved compensations for attenuation, scatter, and geometric collimator response; evaluation of single photon emission computed tomography (SPECT) quantification of iodine 123 and astatine 211; and the development and evaluation of SPECT pinhole imaging for low and medium energy photons.

  4. SPECT-OPT multimodal imaging enables accurate evaluation of radiotracers for β-cell mass assessments

    PubMed Central

    Eter, Wael A.; Parween, Saba; Joosten, Lieke; Frielink, Cathelijne; Eriksson, Maria; Brom, Maarten; Ahlgren, Ulf; Gotthardt, Martin

    2016-01-01

    Single Photon Emission Computed Tomography (SPECT) has become a promising experimental approach to monitor changes in β-cell mass (BCM) during diabetes progression. SPECT imaging of pancreatic islets is most commonly cross-validated by stereological analysis of histological pancreatic sections after insulin staining. Typically, stereological methods do not accurately determine the total β-cell volume, which is inconvenient when correlating total pancreatic tracer uptake with BCM. Alternative methods are therefore warranted to cross-validate β-cell imaging using radiotracers. In this study, we introduce multimodal SPECT - optical projection tomography (OPT) imaging as an accurate approach to cross-validate radionuclide-based imaging of β-cells. Uptake of a promising radiotracer for β-cell imaging by SPECT, 111In-exendin-3, was measured by ex vivo-SPECT and cross evaluated by 3D quantitative OPT imaging as well as with histology within healthy and alloxan-treated Brown Norway rat pancreata. SPECT signal was in excellent linear correlation with OPT data as compared to histology. While histological determination of islet spatial distribution was challenging, SPECT and OPT revealed similar distribution patterns of 111In-exendin-3 and insulin positive β-cell volumes between different pancreatic lobes, both visually and quantitatively. We propose ex vivo SPECT-OPT multimodal imaging as a highly accurate strategy for validating the performance of β-cell radiotracers. PMID:27080529

  5. SPECT-OPT multimodal imaging enables accurate evaluation of radiotracers for β-cell mass assessments.

    PubMed

    Eter, Wael A; Parween, Saba; Joosten, Lieke; Frielink, Cathelijne; Eriksson, Maria; Brom, Maarten; Ahlgren, Ulf; Gotthardt, Martin

    2016-01-01

    Single Photon Emission Computed Tomography (SPECT) has become a promising experimental approach to monitor changes in β-cell mass (BCM) during diabetes progression. SPECT imaging of pancreatic islets is most commonly cross-validated by stereological analysis of histological pancreatic sections after insulin staining. Typically, stereological methods do not accurately determine the total β-cell volume, which is inconvenient when correlating total pancreatic tracer uptake with BCM. Alternative methods are therefore warranted to cross-validate β-cell imaging using radiotracers. In this study, we introduce multimodal SPECT - optical projection tomography (OPT) imaging as an accurate approach to cross-validate radionuclide-based imaging of β-cells. Uptake of a promising radiotracer for β-cell imaging by SPECT, (111)In-exendin-3, was measured by ex vivo-SPECT and cross evaluated by 3D quantitative OPT imaging as well as with histology within healthy and alloxan-treated Brown Norway rat pancreata. SPECT signal was in excellent linear correlation with OPT data as compared to histology. While histological determination of islet spatial distribution was challenging, SPECT and OPT revealed similar distribution patterns of (111)In-exendin-3 and insulin positive β-cell volumes between different pancreatic lobes, both visually and quantitatively. We propose ex vivo SPECT-OPT multimodal imaging as a highly accurate strategy for validating the performance of β-cell radiotracers. PMID:27080529

  6. Evaluation of quantitative accuracy in CZT-based pre-clinical SPECT for various isotopes

    NASA Astrophysics Data System (ADS)

    Park, S.-J.; Yu, A. R.; Kim, Y.-s.; Kang, W.-S.; Jin, S. S.; Kim, J.-S.; Son, T. J.; Kim, H.-J.

    2015-05-01

    In vivo pre-clinical single-photon emission computed tomography (SPECT) is a valuable tool for functional small animal imaging, but several physical factors, such as scatter radiation, limit the quantitative accuracy of conventional scintillation crystal-based SPECT. Semiconductor detectors such as CZT overcome these deficiencies through superior energy resolution. To our knowledge, little scientific information exists regarding the accuracy of quantitative analysis in CZT-based pre-clinical SPECT systems for different isotopes. The aim of this study was to assess the quantitative accuracy of CZT-based pre-clinical SPECT for four isotopes: 201Tl, 99mTc, 123I, and 111In. The quantitative accuracy of the CZT-based Triumph X-SPECT (Gamma-Medica Ideas, Northridge, CA, U.S.A.) was compared with that of a conventional SPECT using GATE simulation. Quantitative errors due to the attenuation and scatter effects were evaluated for all four isotopes with energy windows of 5%, 10%, and 20%. A spherical source containing the isotope was placed at the center of the air-or-water-filled mouse-sized cylinder phantom. The CZT-based pre-clinical SPECT was more accurate than the conventional SPECT. For example, in the conventional SPECT with an energy window of 10%, scatter effects degraded quantitative accuracy by up to 11.52%, 5.10%, 2.88%, and 1.84% for 201Tl, 99mTc, 123I, and 111In, respectively. However, with the CZT-based pre-clinical SPECT, the degradations were only 9.67%, 5.45%, 2.36%, and 1.24% for 201Tl, 99mTc, 123I, and 111In, respectively. As the energy window was increased, the quantitative errors increased in both SPECT systems. Additionally, the isotopes with lower energy of photon emissions had greater quantitative error. Our results demonstrated that the CZT-based pre-clinical SPECT had lower overall quantitative errors due to reduced scatter and high detection efficiency. Furthermore, the results of this systematic assessment quantifying the accuracy of these SPECT

  7. Automatic estimation of detector radial position for contoured SPECT acquisition using CT images on a SPECT/CT system.

    PubMed

    Liu, Ruijie Rachel; Erwin, William D

    2006-08-01

    An algorithm was developed to estimate noncircular orbit (NCO) single-photon emission computed tomography (SPECT) detector radius on a SPECT/CT imaging system using the CT images, for incorporation into collimator resolution modeling for iterative SPECT reconstruction. Simulated male abdominal (arms up), male head and neck (arms down) and female chest (arms down) anthropomorphic phantom, and ten patient, medium-energy SPECT/CT scans were acquired on a hybrid imaging system. The algorithm simulated inward SPECT detector radial motion and object contour detection at each projection angle, employing the calculated average CT image and a fixed Hounsfield unit (HU) threshold. Calculated radii were compared to the observed true radii, and optimal CT threshold values, corresponding to patient bed and clothing surfaces, were found to be between -970 and -950 HU. The algorithm was constrained by the 45 cm CT field-of-view (FOV), which limited the detected radii to < or = 22.5 cm and led to occasional radius underestimation in the case of object truncation by CT. Two methods incorporating the algorithm were implemented: physical model (PM) and best fit (BF). The PM method computed an offset that produced maximum overlap of calculated and true radii for the phantom scans, and applied that offset as a calculated-to-true radius transformation. For the BF method, the calculated-to-true radius transformation was based upon a linear regression between calculated and true radii. For the PM method, a fixed offset of +2.75 cm provided maximum calculated-to-true radius overlap for the phantom study, which accounted for the camera system's object contour detect sensor surface-to-detector face distance. For the BF method, a linear regression of true versus calculated radius from a reference patient scan was used as a calculated-to-true radius transform. Both methods were applied to ten patient scans. For -970 and -950 HU thresholds, the combined overall average root-mean-square (rms

  8. Automatic estimation of detector radial position for contoured SPECT acquisition using CT images on a SPECT/CT system

    SciTech Connect

    Liu Ruijie Rachel; Erwin, William D.

    2006-08-15

    An algorithm was developed to estimate noncircular orbit (NCO) single-photon emission computed tomography (SPECT) detector radius on a SPECT/CT imaging system using the CT images, for incorporation into collimator resolution modeling for iterative SPECT reconstruction. Simulated male abdominal (arms up), male head and neck (arms down) and female chest (arms down) anthropomorphic phantom, and ten patient, medium-energy SPECT/CT scans were acquired on a hybrid imaging system. The algorithm simulated inward SPECT detector radial motion and object contour detection at each projection angle, employing the calculated average CT image and a fixed Hounsfield unit (HU) threshold. Calculated radii were compared to the observed true radii, and optimal CT threshold values, corresponding to patient bed and clothing surfaces, were found to be between -970 and -950 HU. The algorithm was constrained by the 45 cm CT field-of-view (FOV), which limited the detected radii to {<=}22.5 cm and led to occasional radius underestimation in the case of object truncation by CT. Two methods incorporating the algorithm were implemented: physical model (PM) and best fit (BF). The PM method computed an offset that produced maximum overlap of calculated and true radii for the phantom scans, and applied that offset as a calculated-to-true radius transformation. For the BF method, the calculated-to-true radius transformation was based upon a linear regression between calculated and true radii. For the PM method, a fixed offset of +2.75 cm provided maximum calculated-to-true radius overlap for the phantom study, which accounted for the camera system's object contour detect sensor surface-to-detector face distance. For the BF method, a linear regression of true versus calculated radius from a reference patient scan was used as a calculated-to-true radius transform. Both methods were applied to ten patient scans. For -970 and -950 HU thresholds, the combined overall average root-mean-square (rms) error

  9. 3D scintigraphic imaging and navigation in radioguided surgery: freehand SPECT technology and its clinical applications.

    PubMed

    Bluemel, Christina; Matthies, Philipp; Herrmann, Ken; Povoski, Stephen P

    2016-01-01

    Freehand SPECT (fhSPECT) is a technology platform for providing 3-dimensional (3D) navigation for radioguided surgical procedures, such as sentinel lymph node (SLN) biopsy (SLNB). In addition to the information provided by conventional handheld gamma detection probes, fhSPECT allows for direct visualization of the distribution of radioactivity in any given region of interest, allowing for improved navigation to radioactive target lesions and providing accurate lesion depth measurements. Herein, we will review the currently available clinical data on the use of fhSPECT: (i) for SLNB of various malignancies, including difficult-to-detect SLNs, and (ii) for radioguided localization of solid tumors. Moreover, the combination of fhSPECT with other technologies (e.g., small field-of-view gamma cameras, and diagnostic ultrasound) is discussed. These technical advances have the potential to greatly expand the clinical application of radioguided surgery in the future. PMID:26878667

  10. Inverse Bremsstrahlung Stabilization of Noise in the Generation of Ultra-short Intense Pulses by Backward Raman Amplification

    SciTech Connect

    Richard L. Berger; Daniel S. Clark Andrei Solodov; Ernest J. Valeo; Nathaniel J. Fisch

    2003-11-06

    Inverse bremsstrahlung absorption of the pump laser beam in a backward Raman amplifier over the round-trip light transit time through the sub-critical density plasma can more than double the electron temperature of the plasma and produce time-varying axial temperature gradients. The resulting increased Landau damping of the plasma wave and detuning of the resonance can act to stabilize the pump against unwanted amplification of Langmuir noise without disrupting nonlinear amplification of the femtosecond seed pulse. Because the heating rate increases with the charge state Z, only low-Z plasmas (hydrogen, helium, or helium-hydrogen mixtures) will maintain a low enough temperature for efficient operation.

  11. The Virtual Correction to Bremsstrahlung in Results High-Energy e+e- Annihilation:. Comparison of Exact Results

    NASA Astrophysics Data System (ADS)

    Yost, S. A.; Glosser, C.; Jadach, S.; Ward, B. F. L.

    2005-04-01

    We have compared the virtual corrections to single hard bremsstrahlung as calculated by S. Jadach, M. Melles, B.F.L. Ward and S.A. Yost to several other expressions. The most recent of these comparisons is to the leptonic tensor calculated by J.H. Kühn and G. Rodrigo for radiative return. Agreement is found to within 10-5 or better, as a fraction of the Born cross section, for most of the range of photon energies. The massless limits have been shown to agree analytically to NLL order.

  12. Comparison of measured and theoretical inverse bremsstrahlung and photoionization absorption of infrared radiation in a H-He plasma.

    NASA Technical Reports Server (NTRS)

    Billman, K. W.; Stallcop, J. R.; Rowley, P. D.; Presley, L. L.

    1972-01-01

    The absorption coefficients of 1.15- and 3.39-micrometer radiation for a homogeneous H-He plasma have been measured in a temperature and electron density range where the major absorption mechanisms are electron-ion inverse bremsstrahlung and neutral-atom photoionization. Measurements were made behind both the incident and reflected shock waves in a driven tube by recording the laser intensity transmitted along the tube diameter as a function of time. The measured values compare well with those obtained from theoretical calculations for a gas in thermodynamic equilibrium.

  13. Experimental and calculated radionuclide production by photonuclear reactions using Bremsstrahlung photons produced by 150 MeV electrons

    SciTech Connect

    Wunstorf, R.; Bugg, W.M.; Parks, C.C.; Gabriel, T.A.; Lewis, T.A.; Dickens, J.K.

    1994-12-31

    We have developed an experimental apparatus to study radionuclide production by photonuclear reactions. A nearly neutron-free bremsstrahlung beam was created by incident electron interactions with a tantalum radiator. We studied photonuclear reactions in different samples, including the elements Be, Na, Si, Cl, and Ge. Decay gamma rays from radionuclides having half lives > 2 min were analysed. Using the PICA code, we calculated the yield of radionuclides for silicon. We have observed and assigned a new gamma ray transition, of E({gamma}) = 1153 keV, to the decay of 6.6 min 29-Al.

  14. Experimental and calculated radionuclide production by photonuclear reactions using bremsstrahlung photons produced by 150 MeV electrons

    SciTech Connect

    Wunstorf, R.; Bugg, W.M.; Parks, C.C.; Gabriel, T.A.; Lewis, T.A.; Dickens, J.K.

    1995-02-01

    The authors have developed an experimental apparatus to study radionuclide production by photonuclear reactions. A nearly neutron free bremsstrahlung beam was created by incident electron interactions with a tantalum radiator. They studied photonuclear reactions in different samples, including the elements Be, Na, Si, Cl, and Ge. Decay gamma rays from radionuclides having half lives > 2 min were analysed. Using the PICA code, the authors calculated the yield of radionuclides for silicon. They have observed and assigned a new gamma ray transition, of E(y) = 1153 keV, to the decay of 6.6 min 29-Al.

  15. An improved physics-based approach for unfolding megavoltage bremsstrahlung spectra using transmission analysis

    SciTech Connect

    Ali, E. S. M.; Rogers, D. W. O.

    2012-03-15

    Purpose: To develop a physics-based approach to improve the accuracy and robustness of the ill-conditioned problem of unfolding megavoltage bremsstrahlung spectra from transmission data. Methods: Spectra are specified using a rigorously-benchmarked functional form. Since ion chambers are the typical detector used in transmission measurements, the energy response of a Farmer chamber is calculated using the EGSnrc Monte Carlo code, and the effect of approximating the energy response on the accuracy of the unfolded spectra is studied. A proposal is introduced to enhance spectral sensitivity by combining transmission data measured with multiple detectors of different energy response and by combining data from multiple attenuating materials. Monte Carlo methods are developed to correct for nonideal exponential attenuation (e.g., scatter effects and secondary attenuation). The performance of the proposed methods is evaluated for a diverse set of validated clinical spectra (3.5-25 MV) using analytical transmission data with simulated experimental noise. Results: The approximations commonly used in previous studies for the ion-chamber energy response lead to significant errors in the unfolded spectra. Of the configurations studied, the one with best spectral sensitivity is to measure four full transmission curves using separate low-Z and high-Z attenuators in conjunction with two detectors of different energy response (the authors propose a Farmer-type ion chamber, once with a low-Z, and once with a high-Z buildup cap material), then to feed the data simultaneously to the unfolding algorithm. Deviations from ideal exponential attenuation are as much as 1.5% for the smallest transmission signals, and the proposed methods properly correct for those deviations. The transmission data with enhanced spectral sensitivity, combined with the accurate and flexible spectral functional form, lead to robust unfolding without requiring a priori knowledge of the spectrum. Compared with

  16. Test of Compton camera components for prompt gamma imaging at the ELBE bremsstrahlung beam

    NASA Astrophysics Data System (ADS)

    Hueso-González, F.; Golnik, C.; Berthel, M.; Dreyer, A.; Enghardt, W.; Fiedler, F.; Heidel, K.; Kormoll, T.; Rohling, H.; Schöne, S.; Schwengner, R.; Wagner, A.; Pausch, G.

    2014-05-01

    In the context of ion beam therapy, particle range verification is a major challenge for the quality assurance of the treatment. One approach is the measurement of the prompt gamma rays resulting from the tissue irradiation. A Compton camera based on several position sensitive gamma ray detectors, together with an imaging algorithm, is expected to reconstruct the prompt gamma ray emission density map, which is correlated with the dose distribution. At OncoRay and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), a Compton camera setup is being developed consisting of two scatter planes: two CdZnTe (CZT) cross strip detectors, and an absorber consisting of one Lu2SiO5 (LSO) block detector. The data acquisition is based on VME electronics and handled by software developed on the ROOT framework. The setup has been tested at the linear electron accelerator ELBE at HZDR, which is used in this experiment to produce bunched bremsstrahlung photons with up to 12.5 MeV energy and a repetition rate of 13 MHz. Their spectrum has similarities with the shape expected from prompt gamma rays in the clinical environment, and the flux is also bunched with the accelerator frequency. The charge sharing effect of the CZT detector is studied qualitatively for different energy ranges. The LSO detector pixel discrimination resolution is analyzed and it shows a trend to improve for high energy depositions. The time correlation between the pulsed prompt photons and the measured detector signals, to be used for background suppression, exhibits a time resolution of 3 ns FWHM for the CZT detector and of 2 ns for the LSO detector. A time walk correction and pixel-wise calibration is applied for the LSO detector, whose resolution improves up to 630 ps. In conclusion, the detector setup is suitable for time-resolved background suppression in pulsed clinical particle accelerators. Ongoing tasks are the quantitative comparison with simulations and the test of imaging algorithms. Experiments at proton

  17. Design and performance of a multi-pinhole collimation device for small animal imaging with clinical SPECT and SPECT CT scanners

    NASA Astrophysics Data System (ADS)

    Di Filippo, Frank P.

    2008-08-01

    A multi-pinhole collimation device is developed that uses the gamma camera detectors of a clinical SPECT or SPECT-CT scanner to produce high-resolution SPECT images. The device consists of a rotating cylindrical collimator having 22 tungsten pinholes with 0.9 mm diameter apertures and an animal bed inside the collimator that moves linearly to provide helical or ordered-subsets axial sampling. CT images also may be acquired on a SPECT-CT scanner for purposes of image co-registration and SPECT attenuation correction. The device is placed on the patient table of the scanner without attaching to the detectors or scanner gantry. The system geometry is calibrated in-place from point source data and is then used during image reconstruction. The SPECT imaging performance of the device is evaluated with test phantom scans. Spatial resolution from reconstructed point source images is measured to be 0.6 mm full width at half maximum or better. Micro-Derenzo phantom images demonstrate the ability to resolve 0.7 mm diameter rod patterns. The axial slabs of a Micro-Defrise phantom are visualized well. Collimator efficiency exceeds 0.05% at the center of the field of view, and images of a uniform phantom show acceptable uniformity and minimal artifact. The overall simplicity and relatively good imaging performance of the device make it an interesting low-cost alternative to dedicated small animal scanners.

  18. A multipinhole small animal SPECT system with submillimeter spatial resolution

    SciTech Connect

    Funk, Tobias; Despres, Philippe; Barber, William C.; Shah, Kanai S.; Hasegawa, Bruce H.

    2006-05-15

    Single photon emission computed tomography (SPECT) is an important technology for molecular imaging studies of small animals. In this arena, there is an increasing demand for high performance imaging systems that offer improved spatial resolution and detection efficiency. We have designed a multipinhole small animal imaging system based on position sensitive avalanche photodiode (PSAPD) detectors with the goal of submillimeter spatial resolution and high detection efficiency, which will allow us to minimize the radiation dose to the animal and to shorten the time needed for the imaging study. Our design will use 8x24 mm{sup 2} PSAPD detector modules coupled to thallium-doped cesium iodide [CsI(Tl)] scintillators, which can achieve an intrinsic spatial resolution of 0.5 mm at 140 keV. These detectors will be arranged in rings of 24 modules each; the animal is positioned in the center of the 9 stationary detector rings which capture projection data from the animal with a cylindrical tungsten multipinhole collimator. The animal is supported on a bed which can be rocked about the central axis to increase angular sampling of the object. In contrast to conventional SPECT pinhole systems, in our design each pinhole views only a portion of the object. However, the ensemble of projection data from all of the multipinhole detectors provide angular sampling that is sufficient to reconstruct tomographic data from the object. The performance of this multipinhole PSAPD imaging system was simulated using a ray tracing program that models the appropriate point spread functions and then was compared against the performance of a dual-headed pinhole SPECT system. The detection efficiency of both systems was simulated and projection data of a hot rod phantom were generated and reconstructed to assess spatial resolution. Appropriate Poisson noise was added to the data to simulate an acquisition time of 15 min and an activity of 18.5 MBq distributed in the phantom. Both sets of data

  19. Multipinhole collimator with 20 apertures for a brain SPECT application

    SciTech Connect

    Lee, Tzu-Cheng; Ellin, Justin R.; Shrestha, Uttam; Seo, Youngho; Huang, Qiu; Gullberg, Grant T.

    2014-11-01

    Purpose: Several new technologies for single photon emission computed tomography (SPECT) instrumentation with parallel-hole collimation have been proposed to improve detector sensitivity and signal collection efficiency. Benefits from improved signal efficiency include shorter acquisition times and lower dose requirements. In this paper, the authors show a possibility of over an order of magnitude enhancement in photon detection efficiency (from 7.6 × 10{sup −5} to 1.6 × 10{sup −3}) for dopamine transporter (DaT) imaging of the striatum over the conventional SPECT parallel-hole collimators by use of custom-designed 20 multipinhole (20-MPH) collimators with apertures of 0.75 cm diameter. Methods: Quantifying specific binding ratio (SBR) of {sup 123}I-ioflupane or {sup 123}I-iometopane’s signal at the striatal region is a common brain imaging method to confirm the diagnosis of the Parkinson’s disease. The authors performed imaging of a striatal phantom filled with aqueous solution of I-123 and compared camera recovery ratios of SBR acquired between low-energy high-resolution (LEHR) parallel-hole collimators and 20-MPH collimators. Results: With only two-thirds of total acquisition time (20 min against 30 min), a comparable camera recovery ratio of SBR was achieved using 20-MPH collimators in comparison to that from the LEHR collimator study. Conclusions: Their systematic analyses showed that the 20-MPH collimator could be a promising alternative for the DaT SPECT imaging for brain over the traditional LEHR collimator, which could give both shorter scan time and improved diagnostic accuracy.

  20. Impact of reconstruction parameters on quantitative I-131 SPECT.

    PubMed

    van Gils, C A J; Beijst, C; van Rooij, R; de Jong, H W A M

    2016-07-21

    Radioiodine therapy using I-131 is widely used for treatment of thyroid disease or neuroendocrine tumors. Monitoring treatment by accurate dosimetry requires quantitative imaging. The high energy photons however render quantitative SPECT reconstruction challenging, potentially requiring accurate correction for scatter and collimator effects. The goal of this work is to assess the effectiveness of various correction methods on these effects using phantom studies. A SPECT/CT acquisition of the NEMA IEC body phantom was performed. Images were reconstructed using the following parameters: (1) without scatter correction, (2) with triple energy window (TEW) scatter correction and (3) with Monte Carlo-based scatter correction. For modelling the collimator-detector response (CDR), both (a) geometric Gaussian CDRs as well as (b) Monte Carlo simulated CDRs were compared. Quantitative accuracy, contrast to noise ratios and recovery coefficients were calculated, as well as the background variability and the residual count error in the lung insert. The Monte Carlo scatter corrected reconstruction method was shown to be intrinsically quantitative, requiring no experimentally acquired calibration factor. It resulted in a more accurate quantification of the background compartment activity density compared with TEW or no scatter correction. The quantification error relative to a dose calibrator derived measurement was found to be  <1%,-26% and 33%, respectively. The adverse effects of partial volume were significantly smaller with the Monte Carlo simulated CDR correction compared with geometric Gaussian or no CDR modelling. Scatter correction showed a small effect on quantification of small volumes. When using a weighting factor, TEW correction was comparable to Monte Carlo reconstruction in all measured parameters, although this approach is clinically impractical since this factor may be patient dependent. Monte Carlo based scatter correction including accurately simulated CDR

  1. Impact of reconstruction parameters on quantitative I-131 SPECT

    NASA Astrophysics Data System (ADS)

    van Gils, C. A. J.; Beijst, C.; van Rooij, R.; de Jong, H. W. A. M.

    2016-07-01

    Radioiodine therapy using I-131 is widely used for treatment of thyroid disease or neuroendocrine tumors. Monitoring treatment by accurate dosimetry requires quantitative imaging. The high energy photons however render quantitative SPECT reconstruction challenging, potentially requiring accurate correction for scatter and collimator effects. The goal of this work is to assess the effectiveness of various correction methods on these effects using phantom studies. A SPECT/CT acquisition of the NEMA IEC body phantom was performed. Images were reconstructed using the following parameters: (1) without scatter correction, (2) with triple energy window (TEW) scatter correction and (3) with Monte Carlo-based scatter correction. For modelling the collimator-detector response (CDR), both (a) geometric Gaussian CDRs as well as (b) Monte Carlo simulated CDRs were compared. Quantitative accuracy, contrast to noise ratios and recovery coefficients were calculated, as well as the background variability and the residual count error in the lung insert. The Monte Carlo scatter corrected reconstruction method was shown to be intrinsically quantitative, requiring no experimentally acquired calibration factor. It resulted in a more accurate quantification of the background compartment activity density compared with TEW or no scatter correction. The quantification error relative to a dose calibrator derived measurement was found to be  <1%,‑26% and 33%, respectively. The adverse effects of partial volume were significantly smaller with the Monte Carlo simulated CDR correction compared with geometric Gaussian or no CDR modelling. Scatter correction showed a small effect on quantification of small volumes. When using a weighting factor, TEW correction was comparable to Monte Carlo reconstruction in all measured parameters, although this approach is clinically impractical since this factor may be patient dependent. Monte Carlo based scatter correction including accurately simulated

  2. Study of silver K{alpha} and bremsstrahlung radiation from short-pulse laser-matter interactions with applications for x-ray radiography

    SciTech Connect

    Westover, B.; Beg, F. N.; MacPhee, A.; Chen, C.; Hey, D.; Maddox, B.; Park, H.-S.; Remington, B.; Ma, T.

    2010-08-15

    Measurements of K{alpha} radiation yield and x-ray bremsstrahlung emission from thin-foil silver targets are presented. The targets were irradiated by a short pulse laser with intensities from 5x10{sup 16} to 10{sup 18} W/cm{sup 2} at 40 ps. Single hit charge-coupled device detectors, differential filter-stack detectors, and a crystal spectrometer were used to investigate the angular distribution of the K{alpha} and bremsstrahlung x-rays. This study is the first to use a broadband detector to estimate the absolute numbers of K{alpha} photons and to determine K{alpha} to bremsstrahlung ratios. The relevance of this work in the context of x-ray diffraction and x-ray radiography is discussed.

  3. High Sensitivity SPECT for Small Animals and Plants

    SciTech Connect

    Mitchell, Gregory S.

    2015-02-28

    Imaging systems using single gamma-ray emitting radioisotopes typically implement collimators in order to form the images. However, a tradeoff in sensitivity is inherent in the use of collimators, and modern preclinical single-photon emission computed tomography (SPECT) systems detect a very small fraction of emitted gamma-rays (<0.3%). We have built a collimator-less system, which can reach sensitivity of 40% for 99mTc imaging, while still producing images of sufficient spatial resolution for certain applications in thin objects such as mice, small plants, and well plates used for in vitro experiments.

  4. Dose calculations using MARS for Bremsstrahlung beam stops and collimators in APS beamline stations.

    SciTech Connect

    Dooling, J.; Accelerator Systems Division

    2010-11-01

    The Monte Carlo radiation transport code MARS is used to model the generation of gas bremsstrahlung (GB) radiation from 7-GeV electrons which scatter from residual gas atoms in undulator straight sections within the Advanced Photon Source (APS) storage ring. Additionally, MARS is employed to model the interactions of the GB radiation with components along the x-ray beamlines and then determine the expected radiation dose-rates that result. In this manner, MARS can be used to assess the adequacy of existing shielding or the specifications for new shielding when required. The GB radiation generated in the 'thin-target' of an ID straight section will consist only of photons in a 1/E-distribution up to the full energy of the stored electron beam. Using this analytical model, the predicted GB power for a typical APS 15.38-m insertion device (ID) straight section is 4.59 x 10{sup -7} W/nTorr/mA, assuming a background gas composed of air (Z{sub eff} = 7.31) at room temperature (293K). The total GB power provides a useful benchmark for comparisons between analytical and numerical approaches. We find good agreement between MARS and analytical estimates for total GB power. The extended straight section 'target' creates a radial profile of GB, which is highly peaked centered on the electron beam. The GB distribution reflects the size of the electron beam that creates the radiation. Optimizing the performance of MARS in terms of CPU time per incident trajectory requires the use of a relatively short, high-density gas target (air); in this report, the target density is {rho}L = 2.89 x 10{sup -2} g/cm{sup 2} over a length of 24 cm. MARS results are compared with the contact dose levels reported in TB-20, which used EGS4 for radiation transport simulations. Maximum dose-rates in 1 cc of tissue phantom form the initial basis for comparison. MARS and EGS4 results are approximately the same for maximum 1-cc dose-rates and attenuation in the photon-dominated regions; for thicker

  5. Qualitative comparison of bremsstrahlung X-rays and 800 MeV protons for tomography of urania fuel pellets

    DOE PAGESBeta

    Morris, Christopher L.; Bourke, Mark A.; Byler, Darrin D.; Chen, Ching-Fong; Hogan, Gary E.; Hunter, James F.; Kwiatkowski, Kris K.; Mariam, Fesseha G.; McClellan, Kenneth J.; Merrill, Frank E.; et al

    2013-02-11

    We present an assessment of x-rays and proton tomography as tools for studying the time dependence of the development of damage in fuel rods. Also, we show data taken with existing facilities at Los Alamos National Laboratory that support this assessment. Data on surrogate fuel rods has been taken using the 800 MeV proton radiography (pRad) facility at the Los Alamos Neutron Science Center (LANSCE), and with a 450 keV bremsstrahlung X-ray tomography facility. The proton radiography pRad facility at LANSCE can provide good position resolution (<70 μm has been demonstrate, 20 μm seems feasible with minor changes) for tomographymore » on activated fuel rods. Bremsstrahlung x-rays may be able to provide better than 100 μm resolution but further development of sources, collimation and detectors is necessary for x-rays to deal with the background radiation for tomography of activated fuel rods.« less

  6. Coherent bremsstrahlung and channeling radiation from electrons of one to three MeV in silicon and gold

    SciTech Connect

    Watson, James Edwin

    1981-01-01

    The observation of sharp peaks in the x-ray spectrum from 1 to 3 MeV electrons striking thin single crystals of silicon and gold is reported. These peaks were observed in the range 1 to 25 keV. The peaks are of two different origins, both direct results of the periodic nature of the target crystals. The first kind of radiation is caused by the interference of incoming and scattered electron wave functions. Because of the periodicity of the target material there is a coherence effect for certain bremsstrahlung wave vectors. This coherent bremsstrahlung, though well known at very high electron energies, has never been adequately studied at electron energies below several hundred MeV. Detailed agreement between theoretical prediction and observation in silicon is shown. The second kind of radiation is caused by electrons channeled along major crystal axes. The electrons enter certain quantized orbits as they channel and may emit photons as a consequence of transitions between the various orbits. Observations of channeling radiation for various crystal axes in silicon are presented. Both phenomena were observed in gold, the first such observation for any metallic target.

  7. Qualitative comparison of bremsstrahlung X-rays and 800 MeV protons for tomography of urania fuel pellets.

    PubMed

    Morris, C L; Bourke, M; Byler, D D; Chen, C F; Hogan, G; Hunter, J F; Kwiatkowski, K; Mariam, F G; McClellan, K J; Merrill, F; Morley, D J; Saunders, A

    2013-02-01

    We present an assessment of x-rays and proton tomography as tools for studying the time dependence of the development of damage in fuel rods. We also show data taken with existing facilities at Los Alamos National Laboratory that support this assessment. Data on surrogate fuel rods have been taken using the 800 MeV proton radiography (pRad) facility at the Los Alamos Neutron Science Center (LANSCE), and with a 450 keV bremsstrahlung X-ray tomography facility. The proton radiography pRad facility at LANSCE can provide good position resolution (<70 μm has been demonstrate, 20 μm seems feasible with minor changes) for tomography on activated fuel rods. Bremsstrahlung x-rays may be able to provide better than 100 μm resolution but further development of sources, collimation, and detectors is necessary for x-rays to deal with the background radiation for tomography of activated fuel rods. PMID:23464222

  8. Thick target bremsstrahlung spectra for 1.00-, 1.25-, and 1.40-Mev electrons

    USGS Publications Warehouse

    Miller, W.; Motz, J.W.; Cialella, C.

    1954-01-01

    The spectrum of radiation produced by 1.0-, 1.25-, and 1.40-Mev electrons incident on a thick tungsten target was measured at 0A????and 90A????with the incident beam by a method involving the magnetic analysis of Compton electrons. The effects of electron scattering and energy loss in the target preclude any simple interpretation of this data to yield a differential bremsstrahlung cross section. However, an estimate of the spectra to be expected at 0A????and 90A????was obtained by combining the Sauter expression for the bremsstrahlung cross section with the available information on electron scatter and energy loss in the target and backscatter from the target. The reliability of the estimate is limited because the Sauter formula was calculated by using the Born approximation, the electron scattering calculations are applicable to an infinite medium only, and the backscatter was estimated empirically from Bothe's experimental data which were obtained with lower energy electrons (370 kev). Furthermore electron energy straggling was neglected. Nevertheless, the predicted spectral shapes at 0A????and 90A????and the relative intensities at these two angles are in qualitative agreement with the measured values. The absolute magnitudes of the measured intensities at both angles are about a factor of two greater than the predicted values. ?? 1954 The American Physical Society.

  9. The polarization and directivity of solar-flare hard X-ray bremsstrahlung from a thermal source

    NASA Technical Reports Server (NTRS)

    Emslie, A. G.; Brown, J. C.

    1980-01-01

    The polarization and directivity of hard X-ray bremsstrahlung from a thermal source consisting of a region in which a thermal flux drives a pair of steel collisionless conduction fronts were evaluated. The conduction fronts are symmetrically driven from a central region, heated by the flare energy dissipation process. By comparing results with similar calculations based on a nonthermal thick-target electron beam model of the source, it was aimed to determine the degree to which the observed polarization and directivity of solar flare hard X-rays favor either model. Results which exhibit significant polarization and directivity of the hard X-ray radiation emitted by the source are produced by using Maxwellian electron-phase-space distribution functions modified to take into account a directional heat flux and a steady direct current in the X-ray source, and a fully relativistic treatment of the bremsstrahlung emission process. The results are consistent with solar hard X-ray anisotropy and polarization observations to date, although these observations are too crude to be conclusive.

  10. Bremsstrahlung and K(alpha) fluorescence measurements for inferring conversion efficiencies into fast ignition relevant hot electrons

    SciTech Connect

    Chen, C D; Patel, P K; Hey, D S; Mackinnon, A J; Key, M H; Akli, K U; Bartal, T; Beg, F N; Chawla, S; Chen, H; Freeman, R R; Higginson, D P; Link, A; Ma, T Y; MacPhee, A G; Stephens, R B; Van Woerkom, L D; Westover, B; Porkolab, M

    2009-07-24

    The Bremsstrahlung and K-shell emission from 1 mm x 1 mm x 1 mm planar targets irradiated by a short-pulse 3 x 10{sup 18}-8 x 10{sup 19} W/cm{sup 2} laser were measured. The Bremsstrahlung was measured using a filter stack spectrometer with spectral discrimination up to 500 keV. K-shell emission was measured using a single photon counting charge coupled device (CCD). From Monte Carlo modeling of the target emission, conversion efficiencies into 1-3 MeV electrons of 3-12%, representing 20-40% total conversion efficiencies were inferred for intensities up to 8 x 10{sup 19} W/cm{sup 2}. Comparisons to scaling laws using synthetic energy spectra generated from the intensity distribution of the focal spot imply slope temperatures less than the ponderomotive potential of the laser. Resistive transport effects may result in potentials of a few hundred kV in the first few tens of microns in the target. This would lead to higher total conversion efficiencies than inferred from Monte Carlo modeling but lower conversion efficiencies into 1-3 MeV electrons.

  11. Contribution of polarization bremsstrahlung to the total continuum radiation spectra of Xe and Kr using 25 keV electrons

    NASA Astrophysics Data System (ADS)

    Portillo, Salvador; Quarles, C. A.

    1999-10-01

    Recent theoretical calculations of polarization bremsstrahlung (PB)footnote A.V. Korol, J.Phys. B 30, 1997, L115-L121 suggest that this process leads to an increase in the total continuum radiation spectrum specifically more so at energies below the absorption edges of the target atom. Earlier work by the authors on thin film targetsfootnote Quarles, App. of Acc. in Phys. and Tech., 1998, 174-177 suggested that it was not possible to ascertain the PB contribution due to screening arising from multiple atom interactions. Present work aims to eliminate this interaction by focusing on gas targets. We have also attempted to minimize the background from elastically scattered electrons as well as devise a better model for the absorption due to the Kapton window and to the detector itself. We present data and the analysis of a possible PB contribution to the total bremsstrahlung spectrum for 25 keV electrons on Xe and Kr. Present analysis shows that the addition of PB leads to an improved fit for the Xe but not for the Kr.

  12. Isotopic distributions and elemental yields for the photofission of /sup 235,238/U with 12--30-MeV bremsstrahlung

    SciTech Connect

    De Frenne, D.; Thierens, H.; Proot, B.; Jacobs, E.; De Gelder, P.; De Clercq, A.

    1984-05-01

    Combining independent yields directly measured or calculated from the charge distribution, the Kr, Rb, Sr, Sn, Sb, Te, Xe, Cs, and Ba isotopic distributions were investigated for the 12--30-MeV bremsstrahlung-induced photofission of /sup 235/U. At the same bremsstrahlung endpoint energies the Rb, Sn, Sb, Te, I, and Xe isotopic distributions were studied for the photofission of /sup 238/U. For both fissioning systems the tin distributions were significantly broader than all other distributions. From the elemental yields the proton odd-even effects were calculated as a function of Z. They turned out to be almost zero.

  13. Product yields of sup 235 U, sup 238 U, sup 237 Np, and sup 239 Pu by photofission reactions with 20-, 30-, and 60-MeV Bremsstrahlung

    SciTech Connect

    Kase, T.; Yamadera, A.; Nakamura, T. ); Shibata, S. ); Fujiwara, I. )

    1992-08-01

    This paper reports that as a basic study of photonuclear transmutation of actinides in high-level radioactive wastes using electron-produced bremsstrahlung, the absolute yields of cumulative mass distributions and the transmutation rate of {sup 235}U, {sup 238}U, {sup 237}Np, and {sup 239}Pu by photofission reactions induced by 20-, 30-, and 60-MeV bremsstrahlung were measured. The results of mass yield distributions and transmutation yields agree well with other experimental results and those calculated using photofission cross sections, respectively. The transmutation efficiency per electron increases about one order of magnitude with electron energy from 20 to 60 MeV.

  14. Onboard functional and molecular imaging: A design investigation for robotic multipinhole SPECT

    SciTech Connect

    Bowsher, James Giles, William; Yin, Fang-Fang; Yan, Susu; Roper, Justin

    2014-01-15

    Purpose: Onboard imaging—currently performed primarily by x-ray transmission modalities—is essential in modern radiation therapy. As radiation therapy moves toward personalized medicine, molecular imaging, which views individual gene expression, may also be important onboard. Nuclear medicine methods, such as single photon emission computed tomography (SPECT), are premier modalities for molecular imaging. The purpose of this study is to investigate a robotic multipinhole approach to onboard SPECT. Methods: Computer-aided design (CAD) studies were performed to assess the feasibility of maneuvering a robotic SPECT system about a patient in position for radiation therapy. In order to obtain fast, high-quality SPECT images, a 49-pinhole SPECT camera was designed which provides high sensitivity to photons emitted from an imaging region of interest. This multipinhole system was investigated by computer-simulation studies. Seventeen hot spots 10 and 7 mm in diameter were placed in the breast region of a supine female phantom. Hot spot activity concentration was six times that of background. For the 49-pinhole camera and a reference, more conventional, broad field-of-view (FOV) SPECT system, projection data were computer simulated for 4-min scans and SPECT images were reconstructed. Hot-spot localization was evaluated using a nonprewhitening forced-choice numerical observer. Results: The CAD simulation studies found that robots could maneuver SPECT cameras about patients in position for radiation therapy. In the imaging studies, most hot spots were apparent in the 49-pinhole images. Average localization errors for 10-mm- and 7-mm-diameter hot spots were 0.4 and 1.7 mm, respectively, for the 49-pinhole system, and 3.1 and 5.7 mm, respectively, for the reference broad-FOV system. Conclusions: A robot could maneuver a multipinhole SPECT system about a patient in position for radiation therapy. The system could provide onboard functional and molecular imaging with 4-min

  15. Onboard functional and molecular imaging: A design investigation for robotic multipinhole SPECT

    PubMed Central

    Bowsher, James; Yan, Susu; Roper, Justin; Giles, William; Yin, Fang-Fang

    2014-01-01

    Purpose: Onboard imaging—currently performed primarily by x-ray transmission modalities—is essential in modern radiation therapy. As radiation therapy moves toward personalized medicine, molecular imaging, which views individual gene expression, may also be important onboard. Nuclear medicine methods, such as single photon emission computed tomography (SPECT), are premier modalities for molecular imaging. The purpose of this study is to investigate a robotic multipinhole approach to onboard SPECT. Methods: Computer-aided design (CAD) studies were performed to assess the feasibility of maneuvering a robotic SPECT system about a patient in position for radiation therapy. In order to obtain fast, high-quality SPECT images, a 49-pinhole SPECT camera was designed which provides high sensitivity to photons emitted from an imaging region of interest. This multipinhole system was investigated by computer-simulation studies. Seventeen hot spots 10 and 7 mm in diameter were placed in the breast region of a supine female phantom. Hot spot activity concentration was six times that of background. For the 49-pinhole camera and a reference, more conventional, broad field-of-view (FOV) SPECT system, projection data were computer simulated for 4-min scans and SPECT images were reconstructed. Hot-spot localization was evaluated using a nonprewhitening forced-choice numerical observer. Results: The CAD simulation studies found that robots could maneuver SPECT cameras about patients in position for radiation therapy. In the imaging studies, most hot spots were apparent in the 49-pinhole images. Average localization errors for 10-mm- and 7-mm-diameter hot spots were 0.4 and 1.7 mm, respectively, for the 49-pinhole system, and 3.1 and 5.7 mm, respectively, for the reference broad-FOV system. Conclusions: A robot could maneuver a multipinhole SPECT system about a patient in position for radiation therapy. The system could provide onboard functional and molecular imaging with 4-min

  16. Detection of Sentinel Lymph Nodes in Gynecologic Tumours by Planar Scintigraphy and SPECT/CT

    PubMed Central

    Kraft, Otakar; Havel, Martin

    2012-01-01

    Objective: Assess the role of planar lymphoscintigraphy and fusion imaging of SPECT/CT in sentinel lymph node (SLN) detection in patients with gynecologic tumours. Material and Methods: Planar scintigraphy and hybrid modality SPECT/CT were performed in 64 consecutive women with gynecologic tumours (mean age 53.6 with range 30-77 years): 36 pts with cervical cancer (Group A), 21 pts with endometrial cancer (Group B), 7 pts with vulvar carcinoma (Group C). Planar and SPECT/CT images were interpreted separately by two nuclear medicine physicians. Efficacy of these two techniques to image SLN were compared. Results: Planar scintigraphy did not image SLN in 7 patients (10.9%), SPECT/CT was negative in 4 patients (6.3%). In 35 (54.7%) patients the number of SLNs captured on SPECT/CT was higher than on planar imaging. Differences in detection of SLN between planar and SPECT/CT imaging in the group of all 64 patients are statistically significant (p<0.05). Three foci of uptake (1.7% from totally visible 177 foci on planar images) in 2 patients interpreted on planar images as hot LNs were found to be false positive non-nodal sites of uptake when further assessed on SPECT/CT. SPECT/CT showed the exact anatomical location of all visualised sentinel nodes. Conclusion: In some patients with gynecologic cancers SPECT/CT improves detection of sentinel lymph nodes. It can image nodes not visible on planar scintigrams, exclude false positive uptake and exactly localise pelvic and paraaortal SLNs. It improves anatomic localization of SLNs. Conflict of interest:None declared. PMID:23486989

  17. Comparison of 4D-microSPECT and microCT for murine cardiac function

    PubMed Central

    Befera, Nicholas T.; Badea, Cristian T.; Johnson, G. Allan

    2014-01-01

    Purpose The objective of this study was to compare a new generation of four-dimensional (4D) microSPECT with microCT for quantitative in vivo assessment of murine cardiac function. Procedures 4D isotropic cardiac images were acquired from normal C57BL/6 mice with either microSPECT at 350-micron resolution (n=6) or microCT at 88-micron resolution (n=6). One additional mouse with myocardial infarction (MI) was scanned with both modalities. Prior to imaging, mice were injected with either 99mTc -tetrofosmin for microSPECT, or a liposomal blood pool contrast agent for microCT. Segmentation of the left ventricle (LV) was performed using Vitrea (Vital Images) software, to derive global and regional function. Results Measures of global LV function between microSPECT and microCT groups were comparable (e.g. ejection fraction=71±6%-microSPECT and 68±4%-microCT). Regional functional indices (wall motion, wall thickening, regional ejection fraction) were also similar for the two modalities. In the mouse with MI, microSPECT identified a large perfusion defect that was not evident with microCT. Conclusions Despite lower spatial resolution, microSPECT was comparable to microCT in the quantitative evaluation of cardiac function. MicroSPECT offers an advantage over microCT in the ability to evaluate myocardial perfusion radiotracer distribution and function simultaneously. MicroSPECT should be considered as an alternative to microCT and MR for preclinical cardiac imaging in the mouse. PMID:24037175

  18. Simultaneous CT and SPECT tomography using CZT detectors

    DOEpatents

    Paulus, Michael J.; Sari-Sarraf, Hamed; Simpson, Michael L.; Britton, Jr., Charles L.

    2002-01-01

    A method for simultaneous transmission x-ray computed tomography (CT) and single photon emission tomography (SPECT) comprises the steps of: injecting a subject with a tracer compound tagged with a .gamma.-ray emitting nuclide; directing an x-ray source toward the subject; rotating the x-ray source around the subject; emitting x-rays during the rotating step; rotating a cadmium zinc telluride (CZT) two-sided detector on an opposite side of the subject from the source; simultaneously detecting the position and energy of each pulsed x-ray and each emitted .gamma.-ray captured by the CZT detector; recording data for each position and each energy of each the captured x-ray and .gamma.-ray; and, creating CT and SPECT images from the recorded data. The transmitted energy levels of the x-rays lower are biased lower than energy levels of the .gamma.-rays. The x-ray source is operated in a continuous mode. The method can be implemented at ambient temperatures.

  19. SPECT in Alzheimer`s disease and the dementias

    SciTech Connect

    Bonte, F.J.

    1991-12-31

    Among 90 patients with a clinical diagnosis of Alzheimer`s disease (AD), two subgroups were identified for special study, including 42 patients who had a history of dementia in one or more first-degree relatives, and 14 who had a diagnosis of early AD. Of the 42 patients with a family history of dementia, 34 out of the 35 patients whose final clinical diagnosis was possible or probable AD had positive SPECT rCBF studies. Studies in the 14 patients thought to have very early AD were positive in 11 cases. This finding suggests that altered cortical physiology, and hence, rCBF, occurs quite early in the course of AD, perhaps before the onset of symptoms. It is possible that Xenon 133 rCBF studies might be used to detect the presence of subclinical AD in a population of individuals at risk to this disorder. Despite the drawbacks of a radionuclide with poor photon energy, Xenon 133, with its low cost and round-the-clock availability, deserves further study. Although the physical characteristics of Xenon 127 might make it preferable as a SPECT tracer, it is still not regularly available, and some instrument systems are not designed to handle its higher photon energies.

  20. Applications of SPECT imaging of dopaminergic neurotransmission in neuropsychiatric disorders.

    PubMed

    Kugaya, A; Fujita, M; Innis, R B

    2000-02-01

    Single photon emission computed tomography (SPECT) tracers selective for pre- and post-synaptic targets have allowed measurements of several aspects of dopaminergic (DA) neurotransmission. In this article, we will first review our DA transporter imaging in Parkinson's disease. We have developed the in vivo dopamine transporter (DAT) imaging with [123I]beta-CIT ((1R)-2beta-Carbomethoxy-3beta-(4-iodophenyl)tropane). This method showed that patients with Parkinson's disease have markedly reduced DAT levels in striatum, which correlated with disease severity and disease progression. Second, we applied DA imaging techniques in patients with schizophrenia. Using amphetamine as a releaser of DA, we observed the enhanced DA release, which was measured by imaging D2 receptors with [123I]IBZM (iodobenzamide), in schizophrenics. Further we developed the measurement of basal synaptic DA levels by AMPT (alpha-methyl-paratyrosine)-induced unmasking of D2 receptors. Finally, we expanded our techniques to the measurement of extrastriatal DA receptors using [123I]epidepride. The findings suggest that SPECT is a useful technique to measure DA transmission in human brain and may further our understanding of the pathophysiology of neuropsychiatric disorders. PMID:10770574

  1. Development of PET and SPECT Probes for Glutamate Receptors

    PubMed Central

    Nakayama, Morio

    2015-01-01

    l-Glutamate and its receptors (GluRs) play a key role in excitatory neurotransmission within the mammalian central nervous system (CNS). Impaired regulation of GluRs has also been implicated in various neurological disorders. GluRs are classified into two major groups: ionotropic GluRs (iGluRs), which are ligand-gated ion channels, and metabotropic GluRs (mGluRs), which are coupled to heterotrimeric guanosine nucleotide binding proteins (G-proteins). Positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging of GluRs could provide a novel view of CNS function and of a range of brain disorders, potentially leading to the development of new drug therapies. Although no satisfactory imaging agents have yet been developed for iGluRs, several PET ligands for mGluRs have been successfully employed in clinical studies. This paper reviews current progress towards the development of PET and SPECT probes for GluRs. PMID:25874256

  2. Intrinsic Feature Pose Measurement for Awake Animal SPECT Imaging

    SciTech Connect

    Goddard Jr, James Samuel; Baba, Justin S; Lee, Seung Joon; Weisenberger, A G; Stolin, A; McKisson, J; Smith, M F

    2009-01-01

    New developments have been made in optical motion tracking for awake animal imaging that measures 3D position and orientation (pose) for a single photon emission computed tomography (SPECT) imaging system. Ongoing SPECT imaging research has been directed towards head motion measurement for brain studies in awake, unrestrained mice. In contrast to previous results using external markers, this work extracts and tracks intrinsic features from multiple camera images and computes relative pose from the tracked features over time. Motion tracking thus far has been limited to measuring extrinsic features such as retro-reflective markers applied to the mouse s head. While this approach has been proven to be accurate, the additional animal handling required to attach the markers is undesirable. A significant improvement in the procedure is achieved by measuring the pose of the head without extrinsic markers using only the external surface appearance. This approach is currently being developed with initial results presented here. The intrinsic features measurement extracts discrete, sparse natural features from 2D images such as eyes, nose, mouth and other visible structures. Stereo correspondence between features for a camera pair is determined for calculation of 3D positions. These features are also tracked over time to provide continuity for surface model fitting. Experimental results from live images are presented.

  3. SPECT reconstruction using DCT-induced tight framelet regularization

    NASA Astrophysics Data System (ADS)

    Zhang, Jiahan; Li, Si; Xu, Yuesheng; Schmidtlein, C. R.; Lipson, Edward D.; Feiglin, David H.; Krol, Andrzej

    2015-03-01

    Wavelet transforms have been successfully applied in many fields of image processing. Yet, to our knowledge, they have never been directly incorporated to the objective function in Emission Computed Tomography (ECT) image reconstruction. Our aim has been to investigate if the ℓ1-norm of non-decimated discrete cosine transform (DCT) coefficients of the estimated radiotracer distribution could be effectively used as the regularization term for the penalized-likelihood (PL) reconstruction, where a regularizer is used to enforce the image smoothness in the reconstruction. In this study, the ℓ1-norm of 2D DCT wavelet decomposition was used as a regularization term. The Preconditioned Alternating Projection Algorithm (PAPA), which we proposed in earlier work to solve penalized likelihood (PL) reconstruction with non-differentiable regularizers, was used to solve this optimization problem. The DCT wavelet decompositions were performed on the transaxial reconstructed images. We reconstructed Monte Carlo simulated SPECT data obtained for a numerical phantom with Gaussian blobs as hot lesions and with a warm random lumpy background. Reconstructed images using the proposed method exhibited better noise suppression and improved lesion conspicuity, compared with images reconstructed using expectation maximization (EM) algorithm with Gaussian post filter (GPF). Also, the mean square error (MSE) was smaller, compared with EM-GPF. A critical and challenging aspect of this method was selection of optimal parameters. In summary, our numerical experiments demonstrated that the ℓ1-norm of discrete cosine transform (DCT) wavelet frame transform DCT regularizer shows promise for SPECT image reconstruction using PAPA method.

  4. New SPECT and PET Radiopharmaceuticals for Imaging Cardiovascular Disease

    PubMed Central

    Sogbein, Oyebola O.; Pelletier-Galarneau, Matthieu; Schindler, Thomas H.; Wei, Lihui; Wells, R. Glenn; Ruddy, Terrence D.

    2014-01-01

    Nuclear cardiology has experienced exponential growth within the past four decades with converging capacity to diagnose and influence management of a variety of cardiovascular diseases. Single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) with technetium-99m radiotracers or thallium-201 has dominated the field; however new hardware and software designs that optimize image quality with reduced radiation exposure are fuelling a resurgence of interest at the preclinical and clinical levels to expand beyond MPI. Other imaging modalities including positron emission tomography (PET) and magnetic resonance imaging (MRI) continue to emerge as powerful players with an expanded capacity to diagnose a variety of cardiac conditions. At the forefront of this resurgence is the development of novel target vectors based on an enhanced understanding of the underlying pathophysiological process in the subcellular domain. Molecular imaging with novel radiopharmaceuticals engineered to target a specific subcellular process has the capacity to improve diagnostic accuracy and deliver enhanced prognostic information to alter management. This paper, while not comprehensive, will review the recent advancements in radiotracer development for SPECT and PET MPI, autonomic dysfunction, apoptosis, atherosclerotic plaques, metabolism, and viability. The relevant radiochemistry and preclinical and clinical development in addition to molecular imaging with emerging modalities such as cardiac MRI and PET-MR will be discussed. PMID:24901002

  5. Quantitative SPECT reconstruction using CT-derived corrections

    NASA Astrophysics Data System (ADS)

    Willowson, Kathy; Bailey, Dale L.; Baldock, Clive

    2008-06-01

    A method for achieving quantitative single-photon emission computed tomography (SPECT) based upon corrections derived from x-ray computed tomography (CT) data is presented. A CT-derived attenuation map is used to perform transmission-dependent scatter correction (TDSC) in conjunction with non-uniform attenuation correction. The original CT data are also utilized to correct for partial volume effects in small volumes of interest. The accuracy of the quantitative technique has been evaluated with phantom experiments and clinical lung ventilation/perfusion SPECT/CT studies. A comparison of calculated values with the known total activities and concentrations in a mixed-material cylindrical phantom, and in liver and cardiac inserts within an anthropomorphic torso phantom, produced accurate results. The total activity in corrected ventilation-subtracted perfusion images was compared to the calibrated injected dose of [99mTc]-MAA (macro-aggregated albumin). The average difference over 12 studies between the known and calculated activities was found to be -1%, with a range of ±7%.

  6. Radiotracers for PET and SPECT studies of neurotransmitter systems

    SciTech Connect

    Fowler, J.S.

    1991-01-01

    The study of neurotransmitter systems is one of the major thrusts in emission tomography today. The current generation of Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) radiotracers examines neurotransmitter properties from a number of different perspectives including their pre and post synaptic sites and the activity of the enzymes which regulate their concentration. Although the dopamine system has been the most extensively investigated, other neurotransmitter systems including the acetylcholine muscarine, serotonin, benzodiazepine, opiate, NMDA and others are also under intensive development. Enzymes involved in the synthesis and regulation of neurotransmitter concentration, for example monoamine oxidase and amino acid decarboxylase has also been probed in vivo. Medical applications range from the study of normal function and the characterization of neurotransmitter activity in neurological and psychiatric diseases and in heart disease and cancer to the study of the binding of therapeutic drugs and substances of abuse. This chapter will provide an overview of the current generation of radiotracers for PET and SPECT studies of neurotransmitter systems including radiotracer design, synthesis localization mechanisms and applications in emission tomography. 60 refs., 1 tab.

  7. Adaptive SPECT imaging with crossed-slit apertures

    PubMed Central

    Durko, Heather L.; Furenlid, Lars R.

    2015-01-01

    Preclinical single-photon emission computed tomography (SPECT) is an essential tool for studying the progression, response to treatment, and physiological changes in small animal models of human disease. The wide range of imaging applications is often limited by the static design of many preclinical SPECT systems. We have developed a prototype imaging system that replaces the standard static pinhole aperture with two sets of movable, keel-edged copper-tungsten blades configured as crossed (skewed) slits. These apertures can be positioned independently between the object and detector, producing a continuum of imaging configurations in which the axial and transaxial magnifications are not constrained to be equal. We incorporated a megapixel silicon double-sided strip detector to permit ultrahigh-resolution imaging. We describe the configuration of the adjustable slit aperture imaging system and discuss its application toward adaptive imaging, and reconstruction techniques using an accurate imaging forward model, a novel geometric calibration technique, and a GPU-based ultra-high-resolution reconstruction code. PMID:26190884

  8. Sequential sup 123 I-IMP-SPECT in acute infantile hemiplegia

    SciTech Connect

    Shirasaka, Y.; Ito, M.; Okuno, T.; Fujii, T.; Mikawa, H. )

    1989-09-01

    Sequential {sup 123}I-N-isopropyl-p-iodoamphetamine (IMP) single-photon emission computed tomography (SPECT) was performed in 2 patients with acute infantile hemiplegia. In both patients, low uptake of IMP was detected in the targeted abnormal hemisphere. The {sup 123}I-IMP-SPECT findings indicative of a pathologic condition persisted even when the clinical findings and electroencephalographic abnormalities improved. Because of its sensitivity, noninvasiveness, and accurate reflection of the cerebral blood flow distribution, {sup 123}I-IMP-SPECT is useful in the examination of acute infantile hemiplegia and in the evaluation of prognosis.

  9. Unusual Adrenal and Brain Metastases From Follicular Thyroid Carcinoma Revealed by 131I SPECT/CT.

    PubMed

    Zhao, Zhen; Shen, Guo-hua; Liu, Bin; Kuang, An-ren

    2016-01-01

    The adrenal metastasis from differentiated thyroid carcinoma is uncommon. Metastatic involvement of both adrenal and brain in the same patient from differentiated thyroid carcinoma is rare. Here, we described an unusual case with iodine-avid lung, bone, adrenal, liver, and brain metastases from follicular thyroid carcinoma confirmed by 131I SPECT/CT. The utilization of SPECT/CT in thyroid cancer patients can detect the presence of metastases and also exclude potential false-positive lesions. Our case demonstrates that SPECT/CT is helpful in localizing and confirming metastatic lesions from differentiated thyroid carcinoma in rare and unusual sites. PMID:26018699

  10. Parathyroid scintigraphy in patients with primary hyperparathyroidism: 99mTc sestamibi SPECT and SPECT/CT.

    PubMed

    Eslamy, Hedieh K; Ziessman, Harvey A

    2008-01-01

    The clinical diagnosis of primary hyperparathyroidism is based largely on serum laboratory test results, as patients often are asymptomatic. Surgery, often with bilateral exploration of the neck, has been considered the definitive treatment for symptomatic disease. However, given that approximately 90% of cases are due to a single parathyroid adenoma, a better treatment may be the selective surgical excision of the hyperfunctioning parathyroid gland after its preoperative identification and localization at radiologic imaging. Scintigraphy and ultrasonography are the imaging modalities most often used for preoperative localization. Various scintigraphic protocols may be used in the clinical setting: Single-phase dual-isotope subtraction imaging, dual-phase single-isotope imaging, or a combination of the two may be used to obtain planar or tomographic views. Single photon emission computed tomography (SPECT) with the use of technetium-99m ((99m)Tc) sestamibi as the radiotracer, especially when combined with x-ray-based computed tomography (CT), is particularly helpful for preoperative localization: The three-dimensional functional information from SPECT is fused with the anatomic information obtained from CT. In addition, knowledge of the anatomy and embryologic development of the parathyroid glands and the pathophysiology of primary hyperparathyroidism aid in the identification and localization of hyperfunctioning glands. PMID:18794320

  11. Reconstruction of a 6-MeV bremsstrahlung spectrum by multi-layer absorption based on LiF:Mg, Cu, P

    NASA Astrophysics Data System (ADS)

    Huang, Jian-Wei; Wang, Nai-Yan

    2014-10-01

    In this paper, TLD (LiF: Mg, Cu, P) is used as detector. A multi-layer absorption (MLA) model is designed. Combined with Monte-Carlo processes, a bremsstrahlung X-ray spectrum is reconstructed by an iterative method; the reconstructed results agree with the results of simulations by the MCNP process essentially, especially in middle energy region.

  12. Impulsive solar X-ray bursts. 3: Polarization and directivity of bremsstrahlung radiation from a beam of electrons directed toward the photosphere

    NASA Technical Reports Server (NTRS)

    Langer, S. H.; Petrosian, V.

    1976-01-01

    The spectrum, directivity and state of polarization is presented of the bremsstrahlung radiation expected from a beam of high energy electrons spiraling along radial magnetic field lines toward the photosphere. The results are used for calculation of the characteristics of the reflected plus direct flux.

  13. Model for bremsstrahlung emission accompanying interactions between protons and nuclei from low energies up to intermediate energies: Role of magnetic emission

    NASA Astrophysics Data System (ADS)

    Maydanyuk, Sergei P.

    2012-07-01

    A model of the bremsstrahlung emission which accompanies proton decay and collisions of protons off nuclei in the low- to intermediate-energy region has been developed. This model includes spin formalism, a potential approach for describing the interaction between protons and nuclei, and an emission that includes a component of the magnetic emission (defined on the basis of the Pauli equation). For the problem of bremsstrahlung during proton decay the role of magnetic emission is studied by using such a model. For the 146Tm nucleus the following has been studied: (1) How much does the magnetic emission change the full bremsstrahlung spectrum? (2) At which angle is the magnetic emission the most intensive relative to the electric emission? (3) Is there some spatial region where the magnetic emission increases strongly relative to the electric emission? (4) How intensive is the magnetic emission in the tunneling region? (5) Which is the maximal probability? Which value does it equal to at the zero-energy limit of the emitted photons? It is demonstrated that the model is able to describe well enough experimental data of bremsstrahlung emission which accompanies collisions of protons off 9C, 64Cu, and 107Ag nuclei at an incident energy of Tlab=72 MeV (at a photon energy up to 60 MeV) and off 9Be, 12C, and 208Pb nuclei at an incident energy of Tlab=140 MeV (at a photon energy up to 120 MeV).

  14. Fragment mass and kinetic energy distributions for the photofission of sup 234 U with 12-, 15-, and 20-MeV bremsstrahlung

    SciTech Connect

    Verboven, M.; Jacobs, E.; Piessens, M.; Pomme, S.; De Frenne, D.; De Clercq, A. )

    1990-07-01

    Energy correlation measurements were performed for the photofission of {sup 234}U with bremsstrahlung with endpoint energy 12, 15, and 20 MeV. Overall fragment provisional and postneutron masses, and postneutron and preneutron kinetic energies, are deduced. The behavior of the fragment mass and total kinetic energy with changing {sup 234}U compound nucleus excitation energy is studied.

  15. Systematization of the yields of products of photonuclear reactions on enriched-tin targets at the bremsstrahlung-photon endpoint energy of 4.5 GeV

    SciTech Connect

    Balabekyan, A. R.

    2008-11-15

    Yields of photonuclear-reaction products formed in targets from separated tin isotopes under the effect of beams of bremsstrahlung photons whose endpoint energy is 4.5 GeV were investigated. The systematization performed on this basis revealed an isoscaling character of the behavior of the production yields for various regions of reaction-product masses.

  16. SPECT imaging evaluation in movement disorders: far beyond visual assessment.

    PubMed

    Badiavas, Kosmas; Molyvda, Elisavet; Iakovou, Ioannis; Tsolaki, Magdalini; Psarrakos, Kyriakos; Karatzas, Nikolaos

    2011-04-01

    Single photon emission computed tomography (SPECT) imaging with (123)I-FP-CIT is of great value in differentiating patients suffering from Parkinson's disease (PD) from those suffering from essential tremor (ET). Moreover, SPECT with (123)I-IBZM can differentiate PD from Parkinson's "plus" syndromes. Diagnosis is still mainly based on experienced observers' visual assessment of the resulting images while many quantitative methods have been developed in order to assist diagnosis since the early days of neuroimaging. The aim of this work is to attempt to categorize, briefly present and comment on a number of semi-quantification methods used in nuclear medicine neuroimaging. Various arithmetic indices have been introduced with region of interest (ROI) manual drawing methods giving their place to automated procedures, while advancing computer technology has allowed automated image registration, fusion and segmentation to bring quantification closer to the final diagnosis based on the whole of the patient's examinations results, clinical condition and response to therapy. The search for absolute quantification has passed through neuroreceptor quantification models, which are invasive methods that involve tracer kinetic modelling and arterial blood sampling, a practice that is not commonly used in a clinical environment. On the other hand, semi-quantification methods relying on computers and dedicated software try to elicit numerical information out of SPECT images. The application of semi-quantification methods aims at separating the different patient categories solving the main problem of finding the uptake in the structures of interest. The semi-quantification methods which were studied fall roughly into three categories, which are described as classic methods, advanced automated methods and pixel-based statistical analysis methods. All these methods can be further divided into various subcategories. The plethora of the existing semi-quantitative methods reinforces

  17. Two-dimensional filtering of SPECT images using the Metz and Wiener filters

    SciTech Connect

    King, M.A.; Schwinger, R.B.; Doherty, P.W.; Penney, B.C.

    1984-11-01

    Two-dimensional filtering, both before and after reconstruction, has been applied to the processing of single photon emission computerized tomographic (SPECT) images. The filters investigated were the count-dependent Metz filter and Wiener filter, both of which automatically adapt to the image being processed. Using a SPECT phantom, with images reconstructed with these filters rather than the ramp, the authors observed a statistically signficant increase in the image contrast for solid Plexiglas spheres, and significant decrease in the percent fractional standard deviation of counts in a region of uniform activity. The adaptability of these filters is demonstrated by a comparison of SPECT acquisition of the phantom at two different count levels. An example of the application to clinical studies is presented. Two-dimensional digital image restoration with these techniques can produce a significant increase in SPECT image quality, with a small cost in processing time when these techniques are implemented on an array processor.

  18. SPECT assay of radiolabeled monoclonal antibodies. Comprehensive progress report, September 1989--February 1992

    SciTech Connect

    Jaszczak, R.J.

    1992-02-01

    The long-term goal of this research project is to develop methods to improve the utility of single photon emission computed tomography (SPECI) to quantify the biodistribution of monoclonal antibodies (MoAbs) labeled with clinically relevant radionuclides ({sup 123}I, {sup 131}I, and {sup 111}In) and with another radionuclide,{sup 211}At, recently used in therapy. We describe here our progress in developing quantitative SPECT methodology for {sup 111}In and {sup 123}I. We have focused our recent research thrusts on the following aspects of SPECT: (1) The development of improved SPECT hardware, such as improved acquisition geometries. (2) The development of better reconstruction methods that provide accurate compensation for the physical factors that affect SPECT quantification. (3) The application of carefully designed simulations and experiments to validate our hardware and software approaches.

  19. Clinical application of SPECT in adrenal imaging with iodine-131 6 beta-iodomethyl-19-norcholesterol

    SciTech Connect

    Ishimura, J.; Kawanaka, M.; Fukuchi, M.

    1989-04-01

    Forty-one patients with or without adrenocortical disorders were studied to evaluate the clinical usefulness of SPECT in adrenal imaging with I-131 Adosterol. In the SPECT images from this study, all glands with either normally functioning or hyperfunctioning adrenal cortices could be detected, while those glands with hypofunctioning adrenal cortices could not be detected. Particularly in transaxial and sagittal slices, the adrenal gland was identified posteriorly and was clearly distinguished from the gallbladder. In preliminary results using SPECT by a standard method, uptake in 68 detectable glands ranged from 1.7% to 4.9% in four glands with Cushing's syndrome, from 1.1% to 1.3% in seven glands with primary aldosteronism, and were distributed below 1.0% in the remaining glands with normally functioning adrenal cortices. These data show that it is possible to evaluate the adrenocortical functioning status simply by analyzing the SPECT images of the adrenal.

  20. Choroidal Metastasis of Papillary Thyroid Carcinoma Demonstrated on SPECT-CT.

    PubMed

    Torun, Nese; Reyhan, Mehmet; Yapar, Ali Fuat; Karatas, Muge

    2016-05-01

    We report a 68-year-old woman with papillary thyroid carcinoma metastasizing to choroid. The choroid metastasis was diagnosed with SPECT-CT and then was treated with high-dose radioactive iodine therapy. PMID:26825205

  1. Fragment properties from fission of actinide nuclei induced by 6-10 MeV bremsstrahlungI

    NASA Astrophysics Data System (ADS)

    Gook, A.; Eckardt, C.; Enders, J.; Freudenberger, M.; von Neumann-Cosel, P.; Oberstedt, A.; Oberstedt, S.; Richter, A.

    Experiments to investigate the photon-induced fission of actinide nuclei at excitation energies in the vicinity of the fission barrier are carried out at the superconducting Darmstadt linear electron accelerator S-DALINAC. A twin-Frisch-grid ionization chamber is used to deduce mass, total kinetic energy, and angular distributions of the fission fragments. First experiments on 238U and 234U have shown that the experimental setup provides excellent conditions for investigating low-energy bremsstrahlung induced fission. Further experiments on 234U and 232Th are currently in progress. In this contribution results from the first experiment on fission fragment mass and total kinetic energy distributions from 234,238U are presented along with preliminary data from an on-going investigation of angular distributions from 234U(γ, f)

  2. Measurements and effects of backstreaming ions produced at bremsstrahlung converter target in Dragon-I linear induction accelerator

    SciTech Connect

    Yu Haijun; Zhu Jun; Chen Nan; Xie Yutong; Jiang Xiaoguo; Jian Cheng

    2010-04-15

    Positive ions released from x-ray converter target impacted by electron beam of millimeter spot size can be trapped and accelerated in the incident beam's potential well. As the ions move upstream, the beam will be pinched first and then defocused at the target. Four Faraday cups are used to collect backstreaming ions produced at the bremsstrahlung converter target in Dragon-I linear induction accelerator (LIA). Experimental and theoretical results show that the backstreaming positive ions density and velocity are about 10{sup 21}/m{sup 3} and 2-3 mm/{mu}s, respectively. The theoretical and experimental results of electron beam envelope with ions and without ions are also presented. The discussions show that the backstreaming positive ions will not affect the electron beam focusing and envelope radius in Dragon-I LIA.

  3. Measurements and effects of backstreaming ions produced at bremsstrahlung converter target in Dragon-I linear induction accelerator

    NASA Astrophysics Data System (ADS)

    Yu, Haijun; Zhu, Jun; Chen, Nan; Xie, Yutong; Jiang, Xiaoguo; Jian, Cheng

    2010-04-01

    Positive ions released from x-ray converter target impacted by electron beam of millimeter spot size can be trapped and accelerated in the incident beam's potential well. As the ions move upstream, the beam will be pinched first and then defocused at the target. Four Faraday cups are used to collect backstreaming ions produced at the bremsstrahlung converter target in Dragon-I linear induction accelerator (LIA). Experimental and theoretical results show that the backstreaming positive ions density and velocity are about 1021/m3 and 2-3 mm/μs, respectively. The theoretical and experimental results of electron beam envelope with ions and without ions are also presented. The discussions show that the backstreaming positive ions will not affect the electron beam focusing and envelope radius in Dragon-I LIA.

  4. Measurements and effects of backstreaming ions produced at bremsstrahlung converter target in Dragon-I linear induction accelerator.

    PubMed

    Yu, Haijun; Zhu, Jun; Chen, Nan; Xie, Yutong; Jiang, Xiaoguo; Jian, Cheng

    2010-04-01

    Positive ions released from x-ray converter target impacted by electron beam of millimeter spot size can be trapped and accelerated in the incident beam's potential well. As the ions move upstream, the beam will be pinched first and then defocused at the target. Four Faraday cups are used to collect backstreaming ions produced at the bremsstrahlung converter target in Dragon-I linear induction accelerator (LIA). Experimental and theoretical results show that the backstreaming positive ions density and velocity are about 10(21)/m(3) and 2-3 mm/micros, respectively. The theoretical and experimental results of electron beam envelope with ions and without ions are also presented. The discussions show that the backstreaming positive ions will not affect the electron beam focusing and envelope radius in Dragon-I LIA. PMID:20441331

  5. QCD corrections to the Drell-Yan process for the Large Hadron Collider (LHC): Vertex functions and gluon bremsstrahlung

    SciTech Connect

    Zykunov, V. A.

    2010-07-15

    With an eye to future experiments at the Large Hadron Collider (LHC), O(aa{sub s}) QCD corrections to the Drell-Yan process are calculated for vertex functions and gluon bremsstrahlung. Use is made of fully differential cross sections, so that the result obtained in the present study can readily be applied in analyzing experimental data (in correcting data from future experiments at LHC). It is shown both analytically and numerically that the results are independent of unphysical parameters, including the parameter separating the regions of soft and hard gluons and the quark mass. A numerical analysis of radiative effects was performed by means of the FORTRAN code READY with allowance for the experimental cuts used at the Compact Muon Solenoid (CMS) detector

  6. An effective potential for electron-nucleus scattering in neutrino-pair bremsstrahlung in neutron star crust

    NASA Astrophysics Data System (ADS)

    Ofengeim, D. D.; Kaminker, A. D.; Yakovlev, D. G.

    2015-12-01

    We derive an analytic approximation for the emissivity of neutrino-pair bremsstrahlung (NPB) due to scattering of electrons by atomic nuclei in a neutron star (NS) crust of any realistic composition. The emissivity is expressed through generalized Coulomb logarithm by introducing an effective potential of electron-nucleus scattering. In addition, we study the conditions at which NPB in the crust is affected by strong magnetic fields and outline the main effects of the fields on neutrino emission in NSs. The results can be used for modelling of many phenomena in NSs, such as cooling of young isolated NSs, thermal relaxation of accreting NSs with overheated crust in soft X-ray transients and evolution of magnetars.

  7. Transport of electrons and associated bremsstrahlung through a composite aluminum-lead shield, with applications to spacecraft shielding

    SciTech Connect

    Barnea, G.; Seltzer, S.M.; Berger, M.J.

    1986-07-01

    Monte Carlo calculations have been made of the stopping of electrons and the penetration of secondary bremsstrahlung through layered aluminum-lead spacecraft walls. The results are presented in terms of the resultant radiation dose to objects inside. Dose values for monoenergetic incident electrons are given as a function of the aluminum/lead thickness ratio. These data, integrated over a few typical Earth-orbit electron spectra, demonstate the substantial reduction in radiation dose that can be achieved by replacing a portion of an aluminum shield with an inner layer of lead. The main results were obtained by applying a complex-geometry code to spherical-shell configurations. It was found that these results could be reasonably well approximated by an alternative and more economical approach, involving the use of slab-geometry transport results.

  8. Higher-order corrections to electron-nucleus bremsstrahlung cross sections above a few MeV

    NASA Astrophysics Data System (ADS)

    Mangiarotti, A.; Martins, M. N.

    2016-08-01

    Despite the fact that the first calculations of nuclear bremsstrahlung cross sections were performed for relativistic electrons more than 80 years ago by Sauter, Bethe and Heitler, and Racah, a fully satisfactory solution to this problem is still missing up to the present day. Numerical approaches are impractical for electrons with energies above a few MeV because they require a prohibitively large number of partial waves. Analytic formulae need to describe simultaneously and accurately the interaction with the Coulomb field of the nucleus and the screening effect of the atomic electrons. In the present paper, a state-of-the-art analytic calculation will be discussed. In particular, higher-order corrections to the interaction with the Coulomb field of the nucleus, a subject seldom tackled in the past, are included and compared extensively with published data. The emerged difficulties will be highlighted, but unfortunately they can be overcome only with future large coordinated theoretical and experimental efforts.

  9. A comparison of experiment, CEPXS/ONETRAN, TIGERP, and TIGER net electron emission coefficients for various bremsstrahlung spectra

    SciTech Connect

    Ballard, W.P.; Lorence, L.J. Jr.; Snowden, D.P.; Van Lint, V.A.J.; Beale, E.S.

    1987-12-01

    This work compares a carefully designed experiment to measure photoemission with the predictions of three different codes (CEPXS/ONETRAN, TIGERP, and TIGER) for the complex bremsstrahlung spectra typical of very intense pulsed power x-ray generators. The Monte Carlo codes TIGER and TIGERP can calculate the net photon-induced electron emission but accurate results may require that statistical error be minimized. CEPXS/ONETRAN is a new deterministic coupled electron/photon transport code that is faster than Monte Carlo and is not subject to statistical error. The comparison of net yields is a sensitive test of the relative accuracy and efficiency of these various codes. The authors find that all of the codes substantially agree with the experiments for the forward net yields. However, for reverse net yields from high-Z materials, the codes overpredict relative to measurements.

  10. Simulation of generation of bremsstrahlung gamma quanta upon irradiation of thin metal films by ultra-intense femtosecond laser pulses

    SciTech Connect

    Andreev, Stepan N; Rukhadze, Anri A; Garanin, Sergey G; Yakutov, B P; Tarakanov, V P

    2010-06-23

    We report the results of simulations of generation of bremsstrahlung gamma quanta upon irradiation of a thin-film metal target by ultra-intense femtosecond laser pulses. It is shown by the example of a thin gold target that the mean electron energy is twenty five times higher than the mean energy of gamma quanta generated by them. A simple approximating formula is proposed, which establishes a one-to-one relation between these quantities. The angular distributions of electrons and gamma quanta are studied. It is shown that only the angular distribution of high-energy gamma quanta repeats the angular distribution of the electrons leaving the target. (interaction of laser radiation with matter. laser plasma)

  11. [Study on the dose distribution of 8-MeV bremsstrahlung in mantle field techniques (author's transl)].

    PubMed

    Nemec, H W; Walther, E

    1979-08-01

    The dose distribution within the patient was studied with 8-MeV bremsstrahlung from a linear accelerator during mantle field irradiation using molded shielding blocks. Doses and dose distributions in the different layers of a modified Alderson phantom were measured by means of film dosimetry and related to the dose in the central ray beam at the middle of the body. Dose distribution within unshielded regions perpendicular to the central ray beam generally being relatively homogeneous, the highest relative doses, amounting to ca. 115%, are found in the region of the mandibular angle and in the supraclavicular region; the dose to superficial lymph nodes at the supraclavicular region reaches 100% of the dose in the central ray beam. As a cause for these important doses near the surface of the body are discussed the extension of mantle fields as well as the increased exit dose of the opposed field and the oblique incidence of radiation. PMID:473255

  12. Production of isotopes and isomers with irradiation of Z = 47–50 targets by 23-MeV bremsstrahlung

    SciTech Connect

    Karamian, S. A.; Carroll, J. J.; Aksenov, N. V.; Albin, Yu. A.; Belov, A. G.; Bozhikov, G. A.; Dmitriev, S. N.; Starodub, G. Ya.

    2015-09-15

    The irradiations of Ag to Sn targets by bremsstrahlung generated with 23-MeV electron beams are performed at the MT-25 microtron. Gamma spectra of the induced activities have been measured and the yields of all detected radionuclides and isomers are carefully measured and analyzed. A regular dependence of yields versus changed reaction threshold is confirmed. Many isomers are detected and the suppression of the production probability is observed with growing product spin. Special peculiarities for the isomer-to-ground state ratios were deduced for the {sup 106m}Ag, {sup 108m}Ag, {sup 113m}In, {sup 115m}In, and {sup 123m}Sn isomers. The production of such nuclides as {sup 108m}Ag, {sup 115m}In, {sup 117g}In, and {sup 113m}Cd is of interest for applications, especially when economic methods are available.

  13. U-SPECT-BioFluo: an integrated radionuclide, bioluminescence, and fluorescence imaging platform

    PubMed Central

    2014-01-01

    Background In vivo bioluminescence, fluorescence, and single-photon emission computed tomography (SPECT) imaging provide complementary information about biological processes. However, to date these signatures are evaluated separately on individual preclinical systems. In this paper, we introduce a fully integrated bioluminescence-fluorescence-SPECT platform. Next to an optimization in logistics and image fusion, this integration can help improve understanding of the optical imaging (OI) results. Methods An OI module was developed for a preclinical SPECT system (U-SPECT, MILabs, Utrecht, the Netherlands). The applicability of the module for bioluminescence and fluorescence imaging was evaluated in both a phantom and in an in vivo setting using mice implanted with a 4 T1-luc + tumor. A combination of a fluorescent dye and radioactive moiety was used to directly relate the optical images of the module to the SPECT findings. Bioluminescence imaging (BLI) was compared to the localization of the fluorescence signal in the tumors. Results Both the phantom and in vivo mouse studies showed that superficial fluorescence signals could be imaged accurately. The SPECT and bioluminescence images could be used to place the fluorescence findings in perspective, e.g. by showing tracer accumulation in non-target organs such as the liver and kidneys (SPECT) and giving a semi-quantitative read-out for tumor spread (bioluminescence). Conclusions We developed a fully integrated multimodal platform that provides complementary registered imaging of bioluminescent, fluorescent, and SPECT signatures in a single scanning session with a single dose of anesthesia. In our view, integration of these modalities helps to improve data interpretation of optical findings in relation to radionuclide images. PMID:25386389

  14. Cardiac sarcoidosis demonstrated by Tl-201 and Ga-67 SPECT imaging

    SciTech Connect

    Taki, J.; Nakajima, K.; Bunko, H.; Ohguchi, M.; Tonami, N.; Hisada, K. )

    1990-09-01

    Ga-67 and Tl-201 SPECT was performed to evaluate cardiac sarcoidosis in a 15-year-old boy. Tl-201 SPECT imaging showed decreased uptake in the inferior to lateral wall and Ga-67 accumulation in the area of decreased Tl-201 uptake. These findings suggested cardiac sarcoidosis, and cardiac biopsy confirmed this diagnosis. After corticosteroid therapy, myocardial uptake of Ga-67 disappeared and myocardial TI-201 uptake became more homogeneous.

  15. Hotspot quantification of myocardial focal tracer uptake from molecular targeted SPECT/CT images: experimental validation

    NASA Astrophysics Data System (ADS)

    Liu, Yi-Hwa; Sahul, Zakir; Weyman, Christopher A.; Ryder, William J.; Dione, Donald P.; Dobrucki, Lawrence W.; Mekkaoui, Choukri; Brennan, Matthew P.; Hu, Xiaoyue; Hawley, Christi; Sinusas, Albert J.

    2008-03-01

    We have developed a new single photon emission computerized tomography (SPECT) hotspot quantification method incorporating extra cardiac activity correction and hotspot normal limit estimation. The method was validated for estimation accuracy of myocardial tracer focal uptake in a chronic canine model of myocardial infarction (MI). Dogs (n = 4) at 2 weeks post MI were injected with Tl-201 and a Tc-99m-labeled hotspot tracer targeted at matrix metalloproteinases (MMPs). An external point source filled with Tc-99m was used for a reference of absolute radioactivity. Dual-isotope (Tc-99m/Tl-201) SPECT images were acquired simultaneously followed by an X-ray CT acquisition. Dogs were sacrificed after imaging for myocardial gamma well counting. Images were reconstructed with CT-based attenuation correction (AC) and without AC (NAC) and were quantified using our quantification method. Normal limits for myocardial hotspot uptake were estimated based on 3 different schemes: maximum entropy, meansquared-error minimization (MSEM) and global minimization. Absolute myocardial hotspot uptake was quantified from SPECT images using the normal limits and compared with well-counted radioactivity on a segment-by-segment basis (n = 12 segments/dog). Radioactivity was expressed as % injected dose (%ID). There was an excellent correlation (r = 0.78-0.92) between the estimated activity (%ID) derived using the SPECT quantitative approach and well-counting, independent of AC. However, SPECT quantification without AC resulted in the significant underestimation of radioactivity. Quantification using SPECT with AC and the MSEM normal limit yielded the best results compared with well-counting. In conclusion, focal myocardial "hotspot" uptake of a targeted radiotracer can be accurately quantified in vivo using a method that incorporates SPECT imaging with AC, an external reference, background scatter compensation, and a suitable normal limit. This hybrid SPECT/CT approach allows for the serial

  16. A direct measurement of skull attenuation for quantitative SPECT

    SciTech Connect

    Turkington, T.G.; Gilland, D.R.; Jaszczak, R.J.; Greer, K.L.; Coleman, R.E. . Dept. of Radiology); Smith, M.F. . Dept. of Biomedical Engineering)

    1993-08-01

    The attenuation of 140 keV photons was measured in three empty skulls by placing a [sup 99m]Tc line source inside each one and acquiring projection data. These projections were compared to projections of the line source alone to determine the transmission through each point in the skull surrounding the line source. The effective skull thickness was calculated for each point using an assumed dense bone attenuation coefficient. The relative attenuation for this thickness of bone was compared to that of an equivalent amount of soft tissue to evaluate the increased attenuation of photons in brain SPECT relative to a uniform soft tissue approximation. For the skull regions surrounding most of the brain, the effective bone thickness varied considerably, but was generally less than 6 mm, resulting in a relative attenuation increases of less than 6%.

  17. [Verbal auditory agnosia: SPECT study of the brain].

    PubMed

    Carmona, C; Casado, I; Fernández-Rojas, J; Garín, J; Rayo, J I

    1995-01-01

    Verbal auditory agnosia are rare in clinical practice. Clinically, it characterized by impairment of comprehension and repetition of speech but reading, writing, and spontaneous speech are preserved. So it is distinguished from generalized auditory agnosia by the preserved ability to recognize non verbal sounds. We present the clinical picture of a forty-years-old, right handed woman who developed verbal auditory agnosic after an bilateral temporal ischemic infarcts due to atrial fibrillation by dilated cardiomyopathie. Neurophysiological studies by pure tone threshold audiometry: brainstem auditory evoked potentials and cortical auditory evoked potentials showed sparing of peripheral hearing and intact auditory pathway in brainstem but impaired cortical responses. Cranial CT-SCAN revealed two large hypodenses area involving both cortico-subcortical temporal lobes. Cerebral SPECT using 99mTc-HMPAO as radiotracer showed hypoperfusion just posterior in both frontal lobes nect to Roland's fissure and at level of bitemporal lobes just anterior to Sylvian's fissure. PMID:8556589

  18. PET/SPECT imaging agents for neurodegenerative diseases

    PubMed Central

    Zhu, Lin; Ploessl, Karl; Kung, Hank F.

    2014-01-01

    Single photon emission computed tomography (SPECT) or positron emission computed tomography (PET) imaging agents for neurodegenerative disease have a significant impact on clinical diagnosis and patient care. The examples of Parkinson’s Disease (PD) and Alzheimer’s Disease (AD) imaging agents described in this paper provide a general view on how imaging agents, ie radioactive drugs, are selected, chemically prepared and applied in humans. Imaging the living human brain can provide unique information on the pathology and progression of neurodegenerative diseases, such as AD and PD. The imaging method will also facilitate preclinical and clinical trials of new drugs offering specific information related to drug binding sites in the brain. In the future, chemists will continue to play important roles in identifying specific targets, synthesizing target-specific probes for screening and ultimately testing them by in vitro and in vivo assays. PMID:24676152

  19. Attenuation compensation in mesh-domain OSEM SPECT reconstruction

    NASA Astrophysics Data System (ADS)

    Vogelsang, Levon; Lu, Yao; Yu, Bo; Krol, Andrzej; Xu, Yuesheng; Hu, Xiaofei; Feiglin, David; Lipson, Edward

    2009-02-01

    A new method for attenuation compensation (AC) in mesh-domain SPECT OSEM reconstruction using strip-area approximation (SAAC) is introduced and compared to single-ray AC (SRAC). SAAC uses the polygonal area of the intersection of a mesh element (ME) and a tube-of-response (TOR) for defining an effective length of photon transit and an effective attenuation coefficient. This approach to AC is compared to SRAC, which defines the effective length of photon transit as the intersection of a single ray and a ME and the effective attenuation coefficient as the mean along the ray path. Comparative quantitative and qualitative analysis demonstrated that SAAC outperformed SRAC in terms of reconstruction image accuracy and quality.

  20. Hypertrophic pulmonary osteoarthropathy demonstrated on SPECT/CT.

    PubMed

    Russo, Robert R; Lee, Allen; Mansberg, Robert; Emmett, Louise

    2009-09-01

    A 51-year-old man with a known history of hepatic cirrhosis and a right lung mass presented with hemoptysis and widespread bone pain. Sputum cytology demonstrated atypical cells. A CT scan of the chest demonstrated a 3-cm spiculating mass in the right lower lobe, in addition to nodules in both upper lobes and lymphadenopathy within the mediastinum and both hila. Skeletal scintigraphy was performed to assess for metastatic bone disease, and demonstrated increased tracer uptake along the cortex of the distal femurs bilaterally. There was also low-grade cortical uptake in the mid femur and tibia bilaterally on planar imaging. SPECT/CT was able to improve the specificity of the planar scintigraphic findings, by confirming tracer uptake was localized to the periosteum as expected for hypertrophic pulmonary osteoarthropathy, thereby excluding the presence of skeletal metastases. PMID:19692832