LPS Increases 5-LO Expression on Monocytes via an Activation of Akt-Sp1/NF-κB Pathways.

PubMed

Lee, Seung Jin; Seo, Kyo Won; Kim, Chi Dae

2015-05-01

5-Lipoxygenase (5-LO) plays a pivotal role in the progression of atherosclerosis. Therefore, this study investigated the molecular mechanisms involved in 5-LO expression on monocytes induced by LPS. Stimulation of THP-1 monocytes with LPS (0~3 µg/ml) increased 5-LO promoter activity and 5-LO protein expression in a concentration-dependent manner. LPS-induced 5-LO expression was blocked by pharmacological inhibition of the Akt pathway, but not by inhibitors of MAPK pathways including the ERK, JNK, and p38 MAPK pathways. In line with these results, LPS increased the phosphorylation of Akt, suggesting a role for the Akt pathway in LPS-induced 5-LO expression. In a promoter activity assay conducted to identify transcription factors, both Sp1 and NF-κB were found to play central roles in 5-LO expression in LPS-treated monocytes. The LPS-enhanced activities of Sp1 and NF-κB were attenuated by an Akt inhibitor. Moreover, the LPS-enhanced phosphorylation of Akt was significantly attenuated in cells pretreated with an anti-TLR4 antibody. Taken together, 5-LO expression in LPS-stimulated monocytes is regulated at the transcriptional level via TLR4/Akt-mediated activations of Sp1 and NF-κB pathways in monocytes.

LoWMob: Intra-PAN Mobility Support Schemes for 6LoWPAN

PubMed Central

Bag, Gargi; Raza, Muhammad Taqi; Kim, Ki-Hyung; Yoo, Seung-Wha

2009-01-01

Mobility in 6LoWPAN (IPv6 over Low Power Personal Area Networks) is being utilized in realizing many applications where sensor nodes, while moving, sense and transmit the gathered data to a monitoring server. By employing IEEE802.15.4 as a baseline for the link layer technology, 6LoWPAN implies low data rate and low power consumption with periodic sleep and wakeups for sensor nodes, without requiring them to incorporate complex hardware. Also enabling sensor nodes with IPv6 ensures that the sensor data can be accessed anytime and anywhere from the world. Several existing mobility-related schemes like HMIPv6, MIPv6, HAWAII, and Cellular IP require active participation of mobile nodes in the mobility signaling, thus leading to the mobility-related changes in the protocol stack of mobile nodes. In this paper, we present LoWMob, which is a network-based mobility scheme for mobile 6LoWPAN nodes in which the mobility of 6LoWPAN nodes is handled at the network-side. LoWMob ensures multi-hop communication between gateways and mobile nodes with the help of the static nodes within a 6LoWPAN. In order to reduce the signaling overhead of static nodes for supporting mobile nodes, LoWMob proposes a mobility support packet format at the adaptation layer of 6LoWPAN. Also we present a distributed version of LoWMob, named as DLoWMob (or Distributed LoWMob), which employs Mobility Support Points (MSPs) to distribute the traffic concentration at the gateways and to optimize the multi-hop routing path between source and destination nodes in a 6LoWPAN. Moreover, we have also discussed the security considerations for our proposed mobility schemes. The performance of our proposed schemes is evaluated in terms of mobility signaling costs, end-to-end delay, and packet success ratio. PMID:22346730

LoWMob: Intra-PAN Mobility Support Schemes for 6LoWPAN.

PubMed

Bag, Gargi; Raza, Muhammad Taqi; Kim, Ki-Hyung; Yoo, Seung-Wha

2009-01-01

Mobility in 6LoWPAN (IPv6 over Low Power Personal Area Networks) is being utilized in realizing many applications where sensor nodes, while moving, sense and transmit the gathered data to a monitoring server. By employing IEEE802.15.4 as a baseline for the link layer technology, 6LoWPAN implies low data rate and low power consumption with periodic sleep and wakeups for sensor nodes, without requiring them to incorporate complex hardware. Also enabling sensor nodes with IPv6 ensures that the sensor data can be accessed anytime and anywhere from the world. Several existing mobility-related schemes like HMIPv6, MIPv6, HAWAII, and Cellular IP require active participation of mobile nodes in the mobility signaling, thus leading to the mobility-related changes in the protocol stack of mobile nodes. In this paper, we present LoWMob, which is a network-based mobility scheme for mobile 6LoWPAN nodes in which the mobility of 6LoWPAN nodes is handled at the network-side. LoWMob ensures multi-hop communication between gateways and mobile nodes with the help of the static nodes within a 6LoWPAN. In order to reduce the signaling overhead of static nodes for supporting mobile nodes, LoWMob proposes a mobility support packet format at the adaptation layer of 6LoWPAN. Also we present a distributed version of LoWMob, named as DLoWMob (or Distributed LoWMob), which employs Mobility Support Points (MSPs) to distribute the traffic concentration at the gateways and to optimize the multi-hop routing path between source and destination nodes in a 6LoWPAN. Moreover, we have also discussed the security considerations for our proposed mobility schemes. The performance of our proposed schemes is evaluated in terms of mobility signaling costs, end-to-end delay, and packet success ratio.

Study of vibrational modes in CuxAg1-xIn5S8 mixed crystals by infrared reflection measurements

NASA Astrophysics Data System (ADS)

Gasanly, N. M.

2018-04-01

Infrared reflection spectra of CuxAg1-xIn5S8 mixed crystals, grown by Bridgman method, were studied in the wide frequency range of 50-2000 cm-1. All four infrared-active modes were detected, which are in full agreement with the prediction of group-theoretical analysis. Real and imaginary parts of the dielectric function, refractive index and the energy losses function were evaluated from reflectivity measurements. The frequencies of TO and LO modes and oscillator strengths were also determined. The bands detected in IR spectra of studied crystals were assigned to various vibration types (valence and valence-deformation) on the basis of the symmetrized displacements of atoms obtained employing the Melvin projection operators. The linear dependencies of optical mode frequencies on the composition of CuxAg1-xIn5S8 mixed crystals were obtained. These dependencies display one-mode behavior.

Design of Dual-Mode Local Oscillators Using CMOS Technology for Motion Detection Sensors.

PubMed

Ha, Keum-Won; Lee, Jeong-Yun; Kim, Jeong-Geun; Baek, Donghyun

2018-04-01

Recently, studies have been actively carried out to implement motion detecting sensors by applying radar techniques. Doppler radar or frequency-modulated continuous wave (FMCW) radar are mainly used, but each type has drawbacks. In Doppler radar, no signal is detected when the movement is stopped. Also, FMCW radar cannot function when the detection object is near the sensor. Therefore, by implementing a single continuous wave (CW) radar for operating in dual-mode, the disadvantages in each mode can be compensated for. In this paper, a dual mode local oscillator (LO) is proposed that makes a CW radar operate as a Doppler or FMCW radar. To make the dual-mode LO, a method that controls the division ratio of the phase locked loop (PLL) is used. To support both radar mode easily, the proposed LO is implemented by adding a frequency sweep generator (FSG) block to a fractional-N PLL. The operation mode of the LO is determined by according to whether this block is operating or not. Since most radar sensors are used in conjunction with microcontroller units (MCUs), the proposed architecture is capable of dual-mode operation by changing only the input control code. In addition, all components such as VCO, LDO, and loop filter are integrated into the chip, so complexity and interface issues can be solved when implementing radar sensors. Thus, the proposed dual-mode LO is suitable as a radar sensor.

Design of Dual-Mode Local Oscillators Using CMOS Technology for Motion Detection Sensors

PubMed Central

Lee, Jeong-Yun; Kim, Jeong-Geun

2018-01-01

Recently, studies have been actively carried out to implement motion detecting sensors by applying radar techniques. Doppler radar or frequency-modulated continuous wave (FMCW) radar are mainly used, but each type has drawbacks. In Doppler radar, no signal is detected when the movement is stopped. Also, FMCW radar cannot function when the detection object is near the sensor. Therefore, by implementing a single continuous wave (CW) radar for operating in dual-mode, the disadvantages in each mode can be compensated for. In this paper, a dual mode local oscillator (LO) is proposed that makes a CW radar operate as a Doppler or FMCW radar. To make the dual-mode LO, a method that controls the division ratio of the phase locked loop (PLL) is used. To support both radar mode easily, the proposed LO is implemented by adding a frequency sweep generator (FSG) block to a fractional-N PLL. The operation mode of the LO is determined by according to whether this block is operating or not. Since most radar sensors are used in conjunction with microcontroller units (MCUs), the proposed architecture is capable of dual-mode operation by changing only the input control code. In addition, all components such as VCO, LDO, and loop filter are integrated into the chip, so complexity and interface issues can be solved when implementing radar sensors. Thus, the proposed dual-mode LO is suitable as a radar sensor. PMID:29614777

Study of a condition for the mode conversion from purely perpendicular electrostatic waves to electromagnetic waves

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kalaee, Mohammad Javad, E-mail: mjkalaee@ut.ac.ir; Katoh, Yuto, E-mail: yuto@stpp.gp.tohoku.ac.jp

One of the mechanisms for generating electromagnetic plasma waves (Z-mode and LO-mode) is mode conversion from electrostatic waves into electromagnetic waves in inhomogeneous plasma. Herein, we study a condition required for mode conversion of electrostatic waves propagating purely perpendicular to the ambient magnetic field, by numerically solving the full dispersion relation. An approximate model is derived describing the coupling between electrostatic waves (hot plasma Bernstein mode) and Z-mode waves at the upper hybrid frequency. The model is used to study conditions required for mode conversion from electrostatic waves (electrostatic electron cyclotron harmonic waves, including Bernstein mode) into electromagnetic plasma wavesmore » (LO-mode). It is shown that for mode conversion to occur in inhomogeneous plasma, the angle between the boundary surface and the magnetic field vector should be within a specific range. The range of the angle depends on the norm of the k vector of waves at the site of mode conversion in the inhomogeneous region. The present study reveals that inhomogeneity alone is not a sufficient condition for mode conversion from electrostatic waves to electromagnetic plasma waves and that the angle between the magnetic field and the density gradient plays an important role in the conversion process.« less

LoRa Scalability: A Simulation Model Based on Interference Measurements.

PubMed

Haxhibeqiri, Jetmir; Van den Abeele, Floris; Moerman, Ingrid; Hoebeke, Jeroen

2017-05-23

LoRa is a long-range, low power, low bit rate and single-hop wireless communication technology. It is intended to be used in Internet of Things (IoT) applications involving battery-powered devices with low throughput requirements. A LoRaWAN network consists of multiple end nodes that communicate with one or more gateways. These gateways act like a transparent bridge towards a common network server. The amount of end devices and their throughput requirements will have an impact on the performance of the LoRaWAN network. This study investigates the scalability in terms of the number of end devices per gateway of single-gateway LoRaWAN deployments. First, we determine the intra-technology interference behavior with two physical end nodes, by checking the impact of an interfering node on a transmitting node. Measurements show that even under concurrent transmission, one of the packets can be received under certain conditions. Based on these measurements, we create a simulation model for assessing the scalability of a single gateway LoRaWAN network. We show that when the number of nodes increases up to 1000 per gateway, the losses will be up to 32%. In such a case, pure Aloha will have around 90% losses. However, when the duty cycle of the application layer becomes lower than the allowed radio duty cycle of 1%, losses will be even lower. We also show network scalability simulation results for some IoT use cases based on real data.

Dispersion, mode-mixing and the electron-phonon interaction in nanostructures

NASA Astrophysics Data System (ADS)

Dyson, A.; Ridley, B. K.

2018-03-01

The electron-phonon interaction with polar optical modes in nanostructures is re-examined in the light of phonon dispersion relations and the role of the Fuchs-Kliewer (FK) mode. At an interface between adjacent polar materials the frequencies of the FK mode are drawn from the dielectric constants of the adjacent materials and are significantly smaller than the corresponding frequencies of the longitudinal optic (LO) modes at the zone centre. The requirement that all polar modes satisfy mechanical and electrical boundary conditions forces the modes to become hybrids. For a hybrid to have both FK and LO components the LO mode must have the FK frequency, which can only come about through the reduction associated with phonon dispersion relations. We illustrate the effect of phonon dispersion relations on the Fröhlich interaction by considering a simple linear-chain model of the zincblende lattice. Optical and acoustic modes become mixed towards short wavelengths in both optical and acoustic branches. A study of GaAs, InP and cubic GaN and AlN shows that the polarity of the optical branch and the acousticity of the acoustic branch are reduced by dispersion in equal measures, but the effect is relatively weak. Coupling coefficients quantifying the strengths of the interaction with electrons for optical and acoustic components of mixed modes in the optical branch show that, in most cases, the polar interaction dominates the acoustic interaction, and it is reduced from the long-wavelength result towards the zone boundary by only a few percent. The effect on the lower-frequency FK mode can be large.

Modeling the Energy Performance of LoRaWAN

PubMed Central

2017-01-01

LoRaWAN is a flagship Low-Power Wide Area Network (LPWAN) technology that has highly attracted much attention from the community in recent years. Many LoRaWAN end-devices, such as sensors or actuators, are expected not to be powered by the electricity grid; therefore, it is crucial to investigate the energy consumption of LoRaWAN. However, published works have only focused on this topic to a limited extent. In this paper, we present analytical models that allow the characterization of LoRaWAN end-device current consumption, lifetime and energy cost of data delivery. The models, which have been derived based on measurements on a currently prevalent LoRaWAN hardware platform, allow us to quantify the impact of relevant physical and Medium Access Control (MAC) layer LoRaWAN parameters and mechanisms, as well as Bit Error Rate (BER) and collisions, on energy performance. Among others, evaluation results show that an appropriately configured LoRaWAN end-device platform powered by a battery of 2400 mAh can achieve a 1-year lifetime while sending one message every 5 min, and an asymptotic theoretical lifetime of 6 years for infrequent communication. PMID:29035347

Modeling the Energy Performance of LoRaWAN.

PubMed

Casals, Lluís; Mir, Bernat; Vidal, Rafael; Gomez, Carles

2017-10-16

LoRaWAN is a flagship Low-Power Wide Area Network (LPWAN) technology that has highly attracted much attention from the community in recent years. Many LoRaWAN end-devices, such as sensors or actuators, are expected not to be powered by the electricity grid; therefore, it is crucial to investigate the energy consumption of LoRaWAN. However, published works have only focused on this topic to a limited extent. In this paper, we present analytical models that allow the characterization of LoRaWAN end-device current consumption, lifetime and energy cost of data delivery. The models, which have been derived based on measurements on a currently prevalent LoRaWAN hardware platform, allow us to quantify the impact of relevant physical and Medium Access Control (MAC) layer LoRaWAN parameters and mechanisms, as well as Bit Error Rate (BER) and collisions, on energy performance. Among others, evaluation results show that an appropriately configured LoRaWAN end-device platform powered by a battery of 2400 mAh can achieve a 1-year lifetime while sending one message every 5 min, and an asymptotic theoretical lifetime of 6 years for infrequent communication.

LoRa Scalability: A Simulation Model Based on Interference Measurements

PubMed Central

Haxhibeqiri, Jetmir; Van den Abeele, Floris; Moerman, Ingrid; Hoebeke, Jeroen

2017-01-01

LoRa is a long-range, low power, low bit rate and single-hop wireless communication technology. It is intended to be used in Internet of Things (IoT) applications involving battery-powered devices with low throughput requirements. A LoRaWAN network consists of multiple end nodes that communicate with one or more gateways. These gateways act like a transparent bridge towards a common network server. The amount of end devices and their throughput requirements will have an impact on the performance of the LoRaWAN network. This study investigates the scalability in terms of the number of end devices per gateway of single-gateway LoRaWAN deployments. First, we determine the intra-technology interference behavior with two physical end nodes, by checking the impact of an interfering node on a transmitting node. Measurements show that even under concurrent transmission, one of the packets can be received under certain conditions. Based on these measurements, we create a simulation model for assessing the scalability of a single gateway LoRaWAN network. We show that when the number of nodes increases up to 1000 per gateway, the losses will be up to 32%. In such a case, pure Aloha will have around 90% losses. However, when the duty cycle of the application layer becomes lower than the allowed radio duty cycle of 1%, losses will be even lower. We also show network scalability simulation results for some IoT use cases based on real data. PMID:28545239

GFEChutes Lo-Fi

NASA Technical Reports Server (NTRS)

Gist, Emily; Turner, Gary; Shelton, Robert; Vautier, Mana; Shaikh, Ashraf

2013-01-01

NASA needed to provide a software model of a parachute system for a manned re-entry vehicle. NASA has parachute codes, e.g., the Descent Simulation System (DSS), that date back to the Apollo Program. Since the space shuttle did not rely on parachutes as its primary descent control mechanism, DSS has not been maintained or incorporated into modern simulation architectures such as Osiris and Antares, which are used for new mission simulations. GFEChutes Lo-Fi is an object-oriented implementation of conventional parachute codes designed for use in modern simulation environments. The GFE (Government Furnished Equipment), low-fidelity (Lo-Fi) parachute model (GFEChutes Lo-Fi) is a software package capable of modeling the effects of multiple parachutes, deployed concurrently and/or sequentially, on a vehicle during the subsonic phase of reentry into planetary atmosphere. The term "low-fidelity" distinguishes models that represent the parachutes as simple forces acting on the vehicle, as opposed to independent aerodynamic bodies. GFEChutes Lo-Fi was created from these existing models to be clean, modular, certified as NASA Class C software, and portable, or "plug and play." The GFE Lo-Fi Chutes Model provides basic modeling capability of a sequential series of parachute activities. Actions include deploying the parachute, changing the reefing on the parachute, and cutting away the parachute. Multiple chutes can be deployed at any given time, but all chutes in that case are assumed to behave as individually isolated chutes; there is no modeling of any interactions between deployed chutes. Drag characteristics of a deployed chute are based on a coefficient of drag, the face area of the chute, and the local dynamic pressure only. The orientation of the chute is approximately modeled for purposes of obtaining torques on the vehicle, but the dynamic state of the chute as a separate entity is not integrated - the treatment is simply an approximation. The innovation in GFEChutes

Characterization of mode 1 and mixed-mode failure of adhesive bonds between composite adherends

NASA Technical Reports Server (NTRS)

Mall, S.; Johnson, W. S.

1985-01-01

A combined experimental and analytical investigation of an adhesively bonded composite joint was conducted to characterize both the static and fatigue beyond growth mechanism under mode 1 and mixed-mode 1 and 2 loadings. Two bonded systems were studied: graphite/epoxy adherends bonded with EC 3445 and FM-300 adhesives. For each bonded system, two specimen types were tested: a double-cantilever-beam specimen for mode 1 loading and a cracked-lapshear specimen for mixed-mode 1 and 2 loading. In all specimens tested, failure occurred in the form of debond growth. Debonding always occurred in a cohesive manner with EC 3445 adhesive. The FM-300 adhesive debonded in a cohesive manner under mixed-mode 1 and 2 loading, but in a cohesive, adhesive, or combined cohesive and adhesive manner under mode 1 loading. Total strain-energy release rate appeared to be the driving parameter for debond growth under static and fatigue loadings.

Hyper-Raman and Raman scattering from the polar modes of PbMg1/3Nb2/3O3.

PubMed

Hehlen, B; Amouri, A; Al-Zein, A; Khemakhem, H

2014-01-08

Microhyper-Raman spectroscopy of PbMg(1/3)Nb(2/3)O(3) (PMN) single crystal is performed at room temperature. The use of an optical microscope working in backscattering geometry significantly reduces the LO signal, highlighting thereby the weak contributions underneath. We clearly identify the highest frequency transverse optic mode (TO3) in addition to the previously observed soft TO-doublet at low frequency and TO2 at intermediate frequency. TO3 exhibits strong inhomogeneous broadening but perfectly fulfils the hyper-Raman cubic selection rules. The analysis shows that hyper-Raman spectroscopy is sensitive to all the vibrations of the average cubic Pm3¯m symmetry group of PMN, the three polar F1u- and the silent F2u-symmetry modes. All these vibrations can be identified in the Raman spectra alongside other vibrational bands likely arising from symmetry breaking in polar nanoregions.

Noise exposure alters cyclooxygenase 1 (COX-1) and 5-lipoxygenase (5-LO) expression in the guinea pig cochlea.

PubMed

Heinrich, Ulf-Rüdiger; Selivanova, Oxana; Schmidtmann, Irene; Feltens, Ralph; Brieger, Jürgen; Mann, Wolf J

2010-03-01

Changes in the metabolism of arachidonic acid (AA) might be part of a noise-induced compensatory mechanism with regional specificity. The released imbalance of prostaglandins and leukotrienes, both AA metabolites, might result in altered blood flow regulation in the inner ear and probably contributes to noise-induced hearing loss. The aim of this study was to gain further information about noise-dependent changes in AA metabolism in the mammalian cochlea. In this prospective animal study, 10 male guinea pigs were exposed to tone bursts for 1 h at 70 dB sound pressure level (SPL) (n = 5) or 90 dB SPL (n = 5). Five animals were used as controls. Alterations in cyclooxygenase 1 (COX-1) and 5-lipoxygenase (5-LO) expression were determined by quantitative immunohistochemical analysis in 11 cochlear regions. COX-1 expression was decreased after both 70 dB SPL and 90 dB SPL exposure in most cell types of the organ of Corti and increased in the nerve fibers of the osseous spiral lamina. 5-LO was lowered after 90 dB SPL exposure, preferentially in the third cochlear turn in the organ of Corti, in the first and second turn in spiral ganglion cells, and in all turns in the stria vascularis.

Higgs boson production at hadron colliders at N3LO in QCD

NASA Astrophysics Data System (ADS)

Mistlberger, Bernhard

2018-05-01

We present the Higgs boson production cross section at Hadron colliders in the gluon fusion production mode through N3LO in perturbative QCD. Specifically, we work in an effective theory where the top quark is assumed to be infinitely heavy and all other quarks are considered to be massless. Our result is the first exact formula for a partonic hadron collider cross section at N3LO in perturbative QCD. Furthermore, our result is an analytic computation of a hadron collider cross section involving elliptic integrals. We derive numerical predictions for the Higgs boson cross section at the LHC. Previously this result was approximated by an expansion of the cross section around the production threshold of the Higgs boson and we compare our findings. Finally, we study the impact of our new result on the state of the art prediction for the Higgs boson cross section at the LHC.

Ambient noise tomography of Lo'ihi

NASA Astrophysics Data System (ADS)

McClement, K.; Thurber, C. H.; Teel, A.; Caplan-Auerbach, J.

2012-12-01

Lo'ihi seamount, the youngest volcano in the Hawaiian-Emperor chain, lies approximately 30 km south of Hawai'i Island with its summit still approximately 1 km below sea level. Lo'ihi offers a unique opportunity to study the early formation of a hotspot volcano and can provide insight into the deep internal structure of the other volcanoes that make up the Hawaiian Islands. This study uses Ambient Noise Tomography (ANT) to create a 3D tomographic image of Lo'ihi's S-wave velocity structure from ocean bottom seismometer (OBS) data. ANT has been used in many subaerial studies but has seen very few applications to OBS data. This study uses continuous data recorded in 2010 to 2011 from 12 short-period OBS instruments deployed on and around Lo'ihi. With the farthest distance between stations being just over 30 km, the stations provide a fairly dense coverage mainly for the northern half of the volcano. Following the approach of Masterlark et al. [2010], we computed vertical-vertical and vertical-radial cross-correlations using 97 days of continuous data from the 12 stations to produce the ambient noise Green's functions. From these, dispersion curves were produced over a frequency range from .04 Hz to 0.65 Hz . After a quality control analysis, checkerboard tests were used to determine a suitable cell size for the 2D group velocity inversions. The final step is the inversion of the group velocity dispersion curves to create a 3D Vs model. The 3D Vs image produced through this method does not provide clear evidence of a shallow magma chamber; however, when compared to a previous P-wave velocity (Vp) model [Caplan-Auerbach, 2001], a high Vp/Vs ratio is evident especially at depths from 1 km to 5 km, indicating the presence of highly fractured rock.

77 FR 50185 - LoCorr Fund Management, LLC and LoCorr Investment Trust; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-20

... Fund Management, LLC and LoCorr Investment Trust; Notice of Application August 14, 2012. AGENCY.... Applicants: LoCorr Fund Management, LLC (``LFM'' or the ``Adviser'') and LoCorr Investment Trust (the ``Trust... Mary Kay Frech, Branch Chief, at (202) 551-6821 (Division of Investment Management, Office of...

Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure.

PubMed

He, Jing; Tsai, Louis M; Leong, Yew Ann; Hu, Xin; Ma, Cindy S; Chevalier, Nina; Sun, Xiaolin; Vandenberg, Kirsten; Rockman, Steve; Ding, Yan; Zhu, Lei; Wei, Wei; Wang, Changqi; Karnowski, Alexander; Belz, Gabrielle T; Ghali, Joanna R; Cook, Matthew C; Riminton, D Sean; Veillette, André; Schwartzberg, Pamela L; Mackay, Fabienne; Brink, Robert; Tangye, Stuart G; Vinuesa, Carola G; Mackay, Charles R; Li, Zhanguo; Yu, Di

2013-10-17

Follicular B helper T (Tfh) cells support high affinity and long-term antibody responses. Here we found that within circulating CXCR5⁺ CD4⁺ T cells in humans and mice, the CCR7(lo)PD-1(hi) subset has a partial Tfh effector phenotype, whereas CCR7(hi)PD-1(lo) cells have a resting phenotype. The circulating CCR7(lo)PD-1(hi) subset was indicative of active Tfh differentiation in lymphoid organs and correlated with clinical indices in autoimmune diseases. Thus the CCR7(lo)PD-1(hi) subset provides a biomarker to monitor protective antibody responses during infection or vaccination and pathogenic antibody responses in autoimmune diseases. Differentiation of both CCR7(hi)PD-1(lo) and CCR7(lo)PD-1(hi) subsets required ICOS and BCL6, but not SAP, suggesting that circulating CXCR5⁺ helper T cells are primarily generated before germinal centers. Upon antigen reencounter, CCR7(lo)PD-1(hi) CXCR5⁺ precursors rapidly differentiate into mature Tfh cells to promote antibody responses. Therefore, circulating CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells are generated during active Tfh differentiation and represent a new mechanism of immunological early memory. Copyright © 2013 Elsevier Inc. All rights reserved.

Extraction-controlled terahertz frequency quantum cascade lasers with a diagonal LO-phonon extraction and injection stage.

PubMed

Han, Y J; Li, L H; Grier, A; Chen, L; Valavanis, A; Zhu, J; Freeman, J R; Isac, N; Colombelli, R; Dean, P; Davies, A G; Linfield, E H

2016-12-12

We report an extraction-controlled terahertz (THz)-frequency quantum cascade laser design in which a diagonal LO-phonon scattering process is used to achieve efficient current injection into the upper laser level of each period and simultaneously extract electrons from the adjacent period. The effects of the diagonality of the radiative transition are investigated, and a design with a scaled oscillator strength of 0.45 is shown experimentally to provide the highest temperature performance. A 3.3 THz device processed into a double-metal waveguide configuration operated up to 123 K in pulsed mode, with a threshold current density of 1.3 kA/cm² at 10 K. The QCL structures are modeled using an extended density matrix approach, and the large threshold current is attributed to parasitic current paths associated with the upper laser levels. The simplicity of this design makes it an ideal platform to investigate the scattering injection process.

Y4lO of Rhizobium sp. Strain NGR234 Is a Symbiotic Determinant Required for Symbiosome Differentiation▿

PubMed Central

Yang, Feng-Juan; Cheng, Li-Li; Zhang, Ling; Dai, Wei-Jun; Liu, Zhe; Yao, Nan; Xie, Zhi-Ping; Staehelin, Christian

2009-01-01

Type 3 (T3) effector proteins, secreted by nitrogen-fixing rhizobia with a bacterial T3 secretion system, affect the nodulation of certain host legumes. The open reading frame y4lO of Rhizobium sp. strain NGR234 encodes a protein with sequence similarities to T3 effectors from pathogenic bacteria (the YopJ effector family). Transcription studies showed that the promoter activity of y4lO depended on the transcriptional activator TtsI. Recombinant Y4lO protein expressed in Escherichia coli did not acetylate two representative mitogen-activated protein kinase kinases (human MKK6 and MKK1 from Medicago truncatula), indicating that YopJ-like proteins differ with respect to their substrate specificities. The y4lO gene was mutated in NGR234 (strain NGRΩy4lO) and in NGRΩnopL, a mutant that does not produce the T3 effector NopL (strain NGRΩnopLΩy4lO). When used as inoculants, the symbiotic properties of the mutants differed. Tephrosia vogelii, Phaseolus vulgaris cv. Yudou No. 1, and Vigna unguiculata cv. Sui Qing Dou Jiao formed pink effective nodules with NGR234 and NGRΩnopLΩy4lO. Nodules induced by NGRΩy4lO were first pink but rapidly turned greenish (ineffective nodules), indicating premature senescence. An ultrastructural analysis of the nodules induced by NGRΩy4lO revealed abnormal formation of enlarged infection droplets in ineffective nodules, whereas symbiosomes harboring a single bacteroid were frequently observed in effective nodules induced by NGR234 or NGRΩnopLΩy4lO. It is concluded that Y4lO is a symbiotic determinant involved in the differentiation of symbiosomes. Y4lO mitigated senescence-inducing effects caused by the T3 effector NopL, suggesting synergistic effects for Y4lO and NopL in nitrogen-fixing nodules. PMID:19060155

Y4lO of Rhizobium sp. strain NGR234 is a symbiotic determinant required for symbiosome differentiation.

PubMed

Yang, Feng-Juan; Cheng, Li-Li; Zhang, Ling; Dai, Wei-Jun; Liu, Zhe; Yao, Nan; Xie, Zhi-Ping; Staehelin, Christian

2009-02-01

Type 3 (T3) effector proteins, secreted by nitrogen-fixing rhizobia with a bacterial T3 secretion system, affect the nodulation of certain host legumes. The open reading frame y4lO of Rhizobium sp. strain NGR234 encodes a protein with sequence similarities to T3 effectors from pathogenic bacteria (the YopJ effector family). Transcription studies showed that the promoter activity of y4lO depended on the transcriptional activator TtsI. Recombinant Y4lO protein expressed in Escherichia coli did not acetylate two representative mitogen-activated protein kinase kinases (human MKK6 and MKK1 from Medicago truncatula), indicating that YopJ-like proteins differ with respect to their substrate specificities. The y4lO gene was mutated in NGR234 (strain NGROmegay4lO) and in NGR Omega nopL, a mutant that does not produce the T3 effector NopL (strain NGR Omega nopLOmegay4lO). When used as inoculants, the symbiotic properties of the mutants differed. Tephrosia vogelii, Phaseolus vulgaris cv. Yudou No. 1, and Vigna unguiculata cv. Sui Qing Dou Jiao formed pink effective nodules with NGR234 and NGR Omega nopL Omega y4lO. Nodules induced by NGR Omega y4lO were first pink but rapidly turned greenish (ineffective nodules), indicating premature senescence. An ultrastructural analysis of the nodules induced by NGR Omega y4lO revealed abnormal formation of enlarged infection droplets in ineffective nodules, whereas symbiosomes harboring a single bacteroid were frequently observed in effective nodules induced by NGR234 or NGR Omega nopL Omega y4lO. It is concluded that Y4lO is a symbiotic determinant involved in the differentiation of symbiosomes. Y4lO mitigated senescence-inducing effects caused by the T3 effector NopL, suggesting synergistic effects for Y4lO and NopL in nitrogen-fixing nodules.

Four-Wave-Mixing Oscillations in a simplified Boltzmannian semiconductor model with LO-phonons

NASA Astrophysics Data System (ADS)

Tamborenea, P. I.; Bányai, L.; Haug, H.

1996-03-01

The recently discovered(L. Bányai, D. B. Tran Thoai, E. Reitsamer, H. Haug, D. Steinbach, M. U. Wehner, M. Wegener, T. Marschner and W. Stolz, Phys. Rev. Lett. 75), 2188 (1995). oscillations of the integrated four-wave-mixing signal in semiconductors due to electron-LO-phonon scattering are studied within a simplified Boltzmann-type model. Although several aspects of the experimental results require a description within the framework of non-Markovian quantum-kinetic theory, our simplified Boltzmannian model is well suited to analyze the origin of the observed novel oscillations of frequency (1+m_e/m_h) hbarω_LO. To this end, we developed a third-order, analytic solution of the semiconductor Bloch equations (SBE) with Boltzmann-type, LO-phonon collision terms. Results of this theory along with numerical solutions of the SBE will be presented.

Contributions of different modes of TRPV1 activation to TRPV1 antagonist-induced hyperthermia.

PubMed

Garami, Andras; Shimansky, Yury P; Pakai, Eszter; Oliveira, Daniela L; Gavva, Narender R; Romanovsky, Andrej A

2010-01-27

Transient receptor potential vanilloid-1 (TRPV1) antagonists are widely viewed as next-generation pain therapeutics. However, these compounds cause hyperthermia, a serious side effect. TRPV1 antagonists differentially block three modes of TRPV1 activation: by heat, protons, and chemical ligands (e.g., capsaicin). We asked what combination of potencies in these three modes of TRPV1 activation corresponds to the lowest potency of a TRPV1 antagonist to cause hyperthermia. We studied hyperthermic responses of rats, mice, and guinea pigs to eight TRPV1 antagonists with different pharmacological profiles and used mathematical modeling to find a relative contribution of the blockade of each activation mode to the development of hyperthermia. We found that the hyperthermic effect has the highest sensitivity to the extent of TRPV1 blockade in the proton mode (0.43 to 0.65) with no to moderate sensitivity in the capsaicin mode (-0.01 to 0.34) and no sensitivity in the heat mode (0.00 to 0.01). We conclude that hyperthermia-free TRPV1 antagonists do not block TRPV1 activation by protons, even if they are potent blockers of the heat mode, and that decreasing the potency to block the capsaicin mode may further decrease the potency to cause hyperthermia.

Contributions of different modes of TRPV1 activation to TRPV1 antagonist-induced hyperthermia

PubMed Central

Garami, Andras; Shimansky, Yury P.; Pakai, Eszter; Oliveira, Daniela L.; Gavva, Narender R.; Romanovsky, Andrej A.

2010-01-01

Transient receptor potential vanilloid-1 (TRPV1) antagonists are widely viewed as next-generation pain therapeutics. However, these compounds cause hyperthermia, a serious side effect. TRPV1 antagonists differentially block three modes of TRPV1 activation: by heat, protons, and chemical ligands (e.g., capsaicin). We asked what combination of potencies in these three modes of TRPV1 activation corresponds to the lowest potency of a TRPV1 antagonist to cause hyperthermia. We studied hyperthermic responses of rats, mice, and guinea pigs to eight TRPV1 antagonists with different pharmacological profiles and used mathematical modeling to find a relative contribution of the blockade of each activation mode to the development of hyperthermia. We have found that the hyperthermic effect has the highest sensitivity to the extent of TRPV1 blockade in the proton mode (0.43 to 0.65) with no to moderate sensitivity in the capsaicin mode (-0.01 to 0.34) and no sensitivity in the heat mode (0.00 to 0.01). We conclude that hyperthermia-free TRPV1 antagonists do not block TRPV1 activation by protons, even if they are potent blockers of the heat mode, and that decreasing the potency to block the capsaicin mode may further decrease the potency to cause hyperthermia. PMID:20107070

M = +1, ± 1 and ± 2 mode helicon wave excitation.

NASA Astrophysics Data System (ADS)

Kim, J.-H.; Yun, S.-M.; Chang, H.-Y.

1996-11-01

The characteristics of M=+1, ± 1 and ± 2 modes helicon wave excited using a solenoid antenna, Nagoya type III and quadrupole antenna respectively are first investigated. The solenoid antenna is constructed by winding a copper cable on a quartz discharge tube. Two dimensional cross-field measurements of ArII optical emission induced by hot electrons are made to investigate RF power deposition: Components of the wave magnetic field measured with a single-turn, coaxial magnetic probe were compared with the field patterns computed for M=+1, ± 1 and ± 2 modes. The M=+1 mode plasma produced by the solenoid antenna has a cylindrical high intensity plasma column, which center is empty. This cylindrical high intensity column results from the rotation of the cross-sectional electric field pattern (right hand circularly polarization). The radial plasma density profile has a peak at r=2.5cm with axisymmetry. It has been found that the radial profile of the plasma density is in good agreement with the computed power deposition profile. The radial profiles of the wave magnetic field are in good agreement with computations. The plasma excited by Nagoya type III antenna has two high intensity columns which results from the linear combination of M=+1 and -1 modes (i.e. plane polarization). The radial plasma density profile is in good agreement with emission intensity profile of ArII line (488nm). The plasma excited by quadrupole antenna has four high intensity columns which results from the linear combination of M=+2 and -2 modes (i.e. plane polarization). In the M=± 2 modes, the radial plasma density profile is also in good agreement with emission intensity profile of ArII line.

Raman Scattering Study of Lattice Vibrations in the Type-II Superlattice InAs /InAs1 -xSbx

NASA Astrophysics Data System (ADS)

Liu, Henan; Zhang, Yong; Steenbergen, Elizabeth H.; Liu, Shi; Lin, Zhiyuan; Zhang, Yong-Hang; Kim, Jeomoh; Ji, Mi-Hee; Detchprohm, Theeradetch; Dupuis, Russell D.; Kim, Jin K.; Hawkins, Samuel D.; Klem, John F.

2017-09-01

The InAs /InAs1 -xSbx superlattice system distinctly differs from two well-studied superlattice systems GaAs /AlAs and InAs /GaSb in terms of electronic band alignment, common elements at the interface, and phonon spectrum overlapping of the constituents. This fact leads to the unique electronic and vibrational properties of the InAs /InAs1 -xSbx system when compared to the other two systems. In this work, we report a polarized Raman study of the vibrational properties of the InAs /InAs1 -xSbx superlattices (SLs) as well as selected InAs1 -xSbx alloys, all grown on GaSb substrates by either MBE or metalorganic chemical vapor deposition (MOCVD) from both the growth surface and cleaved edge. In the SL, from the (001) backscattering geometry, an InAs-like longitudinal optical (LO) mode is observed as the primary feature, and its intensity is found to increase with increasing Sb composition. From the (110) cleaved-edge backscattering geometry, an InAs-like transverse optical (TO) mode is observed as the main feature in two cross-polarization configurations, but an additional InAs-like "forbidden" LO mode is observed in two parallel-polarization configurations. The InAs1 -xSbx alloys lattice matched to the substrate (xSb˜0.09 ) grown by MBE are also found to exhibit the forbidden LO mode, implying the existence of some unexpected [001] modulation. However, the strained samples (xSb˜0.35 ) grown by MOCVD are found to behave like a disordered alloy. The primary conclusions are (1) the InAs-like LO or TO mode can be either a confined or quasiconfined mode in the InAs layers of the SL or extended mode of the whole structure depending on the Sb composition. (2) InAs /InAs1 -xSbx and InAs /GaSb SLs exhibit significantly different behaviors in the cleaved-edge geometry but qualitatively similar in the (001) geometry. (3) The appearance of the forbidden LO-like mode is a universal signature for SLs and bulk systems resulting from the mixing of phonon modes due to structural

Characterizing the ``Higgs'' amplitude mode in a Spin-1 Bose Einstein Condensate

NASA Astrophysics Data System (ADS)

Hebbe Madhusudhana, Bharath; Boguslawski, Matthew; Anquez, Martin; Robbins, Bryce; Barrios, Maryrose; Hoang, Thai; Chapman, Michael

2016-05-01

Spontaneous symmetry breaking in a physical system is often characterized by massless Nambu-Goldstone modes and massive Anderson-Higgs modes. It occurs when a system crosses a quantum critical point (QCP) reaching a state does not share the symmetry of the underlying Hamiltonian. In a spin-1 Bose Einstein condensate, the transverse spin component can be considered as an order parameter. A quantum phase transition (QPT) of this system results in breaking of the symmetry group U(1) × SO(2) shared by the Hamiltonian. As a result, two massless coupled phonon-magnon modes are produced along with a single massive mode or a Higgs-like mode, in the form of amplitude excitations of the order parameter. Here we characterize the amplitude excitations experimentally by inducing coherent oscillation in the spin population. We further use the amplitude oscillations to measure the energy gap for different phases of the QPT. At the QCP, finite size effects lead to a non-zero gap, and our measurements are consistent with this prediction.

A Channelized 2nd IF/LO Downconverter for the E0S Microwave Limb Sounder

NASA Technical Reports Server (NTRS)

LaBelle, Remi C.

2003-01-01

The Earth Observing System (EOS) Microwave Limb Sounder (MLS) is scheduled for launch in 2004 on the EOS Aura spacecraft. The design, assembly and test of the flight 2nd Intermediate Frequency/ Local Oscillator (2nd IF/LO) subsystem for this instrument has been completed and is presented here. The 2nd IF/LO subsystem consists of 5 separate microwave assemblies, 1 for each of the 5 millimeter wave radiometer front ends, providing a total of 33 separate IF channels. Some key requirements of the subsystem are as follows: provide frequency multiplexing of overlapping or closely spaced 1st IF channels while maintaining low ripple in the passbands; generate 19 different 2nd LO frequencies, in the range of 4-20 GHz, with low phase noise and a placement resolution of 400 KHz; downconvert the 1st IF's to a common 2nd IF frequency centered at 900 MHz; minimize cost and schedule by using common designs for the 5 different assemblies wherever possible.

Mirror-mode structures at Comet 1P/Halley: A comparison between VEGA1 and Giotto Flyby

NASA Astrophysics Data System (ADS)

Volwerk, M.; Glassmeier, K.-H.; Schmid, D.; Delva, M.; Koenders, C.

2014-04-01

The pickup of freshly ionized particles emitted by the cometary nucleus creates a particle distribution in phase-space which is, amongst others, mirror-mode unstable. Many detailed studies have shown the presence of mirror-mode structures in the vicinity of comet 1P/Halley, using data from VEGA1/2 and Giotto. In the current presentation the almost similar flybys of VEGA1 and Giotto are compared with respect to the presence and occurrence rate of mirrormode structures. An automated search on the magnetic field data is performed, using minimum variance analysis, which has proved its usefulness in earlier mirror-mode studies at Earth, Venus and comets. It is found that there is an asymmetry between the two flybys: both missions show many events before closest approach and magnetic pile up region, however, after closest approach and magnetic pile up region the mirror-modes are strongly reduced at Giotto, whereas they increase in number for VEGA1. One source of influence could be the solar wind IMF, which is different: VEGA1 IMF ≈ (0, 0, 15) nT, Vsw ≈ 500 km/s and Giotto IMF ≈ (-3/3, -4, 5) nT (Bx rotating over the passage), Vsw ≈ 370 km/s. In this presentation we will discuss the occurrence rate, sizes and other characteristics of the mirror-mode structures.

Evolution of Starspots on LO Pegasi

NASA Astrophysics Data System (ADS)

Harmon, Robert; Bloodgood, Felise; Martin, Alec; Pellegrin, Kyle

2018-01-01

LO Pegasi is a young solar analog, a K main-sequence star that rotates with a period of 10.1538 hr. The rapid rotation yields a strong stellar dynamo associated with large starspots on the surface, which are regions where the magnetic field inhibits the convective transport of energy from below, so that the spots are cooler and thus darker than the surrounding photosphere. The star thus exhibits rotational modulation of its light curve as the starspots are carried into and out of view of Earth. CCD images of LO Peg were acquired at Perkins Observatory in Delaware, OH through standard B, V, R, and I photometric filters from 2017 June 1 to July 20. After subtracting dark frames and flat fielding the images, differential aperture photometry was performed to yield light curves through each of the four filters. The resulting light curves that were then analyzed via the Light-curve Inversion program created by one of us (Harmon) to produce surface maps. Our observations indicated that LO Pegasi’s light curve changed in both amplitude and shape between 2017 June and July, while its maximum brightness did not change. We present maps corresponding to these two distinct light curves, along with maps for data acquired from 2006-2016.

Raman Scattering Study of Lattice Vibrations in the Type-II Superlattice InAs / InAs 1 - x Sb x

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Henan; Zhang, Yong; Steenbergen, Elizabeth H.

The InAs/InAs 1-xSb x superlattice system distinctly differs from two well-studied superlattice systems GaAs / AlAs and InAs/GaSb in terms of electronic band alignment, common elements at the interface, and phonon spectrum overlapping of the constituents. This fact leads to the unique electronic and vibrational properties of the InAs/InAs 1-xSb x system when compared to the other two systems. Here, we report a polarized Raman study of the vibrational properties of the InAs/InAs 1-xSb x superlattices (SLs) as well as selected InAs 1-xSb x alloys, all grown on GaSb substrates by either MBE or metalorganic chemical vapor deposition (MOCVD) frommore » both the growth surface and cleaved edge. In the SL, from the (001) backscattering geometry, an InAs-like longitudinal optical (LO) mode is observed as the primary feature, and its intensity is found to increase with increasing Sb composition. From the (110) cleaved-edge backscattering geometry, an InAs-like transverse optical (TO) mode is observed as the main feature in two cross-polarization configurations, but an additional InAs-like “forbidden” LO mode is observed in two parallel-polarization configurations. The InAs 1-xSb x alloys lattice matched to the substrate (x Sb ~ 0.09) grown by MBE are also found to exhibit the forbidden LO mode, implying the existence of some unexpected [001] modulation. However, the strained samples (x Sb ~ 0.35) grown by MOCVD are found to behave like a disordered alloy. The primary conclusions are (1) the InAs-like LO or TO mode can be either a confined or quasiconfined mode in the InAs layers of the SL or extended mode of the whole structure depending on the Sb composition. (2) InAs/InAs 1-xSb x and InAs/GaSb SLs exhibit significantly different behaviors in the cleaved-edge geometry but qualitatively similar in the (001) geometry. (3) The appearance of the forbidden LO-like mode is a universal signature for SLs and bulk systems resulting from the mixing of phonon modes due to

The dating and interpretation of a Mode 1 site in the Luangwa Valley, Zambia.

PubMed

Barham, Lawrence; Phillips, William M; Maher, Barbara A; Karloukovski, Vassil; Duller, Geoff A T; Jain, Mayank; Wintle, Ann G

2011-05-01

Flake based assemblages (Mode 1) comprise the earliest stone technologies known, with well-dated Oldowan sites occurring in eastern Africa between ~2.6-1.7 Ma, and in less securely dated contexts in central, southern and northern Africa. Our understanding of the spread and local development of this technology outside East Africa remains hampered by the lack of reliable numerical dating techniques applicable to non-volcanic deposits. This study applied the still relatively new technique of cosmogenic nuclide burial dating ((10)Be/(26)Al) to calculate burial ages for fluvial gravels containing Mode 1 artefacts in the Luangwa Valley, Zambia. The Manzi River, a tributary of the Luangwa River, has exposed a 4.7 m deep section of fluvial sands with discontinuous but stratified gravel layers bearing Mode 1, possibly Oldowan, artefacts in the basal layers. An unconformity divides the Manzi section, separating Mode 1 deposits from overlying gravels containing Mode 3 (Middle Stone Age) artefacts. No diagnostic Mode 2 (Acheulean) artefacts were found. Cosmogenic nuclide burial dating was attempted for the basal gravels as well as exposure ages for the upper Mode 3 gravels, but was unsuccessful. The complex depositional history of the site prevented the calculation of reliable age models. A relative chronology for the full Manzi sequence was constructed, however, from the magnetostratigraphy of the deposit (N>R>N sequence). Isothermal thermoluminescence (ITL) dating of the upper Mode 3 layers also provided consistent results (~78 ka). A coarse but chronologically coherent sequence now exists for the Manzi section with the unconformity separating probable mid- or early Pleistocene deposits below from late Pleistocene deposits above. The results suggest Mode 1 technology in the Luangwa Valley may post-date the Oldowan in eastern and southern Africa. The dating programme has contributed to a clearer understanding of the geomorphological processes that have shaped the valley and

The dating and interpretation of a Mode 1 site in the Luangwa Valley, Zambia

USGS Publications Warehouse

Barham, L.; Phillips, W.M.; Maher, B.A.; Karloukovski, V.; Duller, G.A.T.; Jain, M.; Wintle, A.G.

2011-01-01

Flake based assemblages (Mode 1) comprise the earliest stone technologies known, with well-dated Oldowan sites occurring in eastern Africa between ??? 2.6-1.7 Ma, and in less securely dated contexts in central, southern and northern Africa. Our understanding of the spread and local development of this technology outside East Africa remains hampered by the lack of reliable numerical dating techniques applicable to non-volcanic deposits. This study applied the still relatively new technique of cosmogenic nuclide burial dating (10Be/26Al) to calculate burial ages for fluvial gravels containing Mode 1 artefacts in the Luangwa Valley, Zambia. The Manzi River, a tributary of the Luangwa River, has exposed a 4.7 m deep section of fluvial sands with discontinuous but stratified gravel layers bearing Mode 1, possibly Oldowan, artefacts in the basal layers. An unconformity divides the Manzi section, separating Mode 1 deposits from overlying gravels containing Mode 3 (Middle Stone Age) artefacts. No diagnostic Mode 2 (Acheulean) artefacts were found. Cosmogenic nuclide burial dating was attempted for the basal gravels as well as exposure ages for the upper Mode 3 gravels, but was unsuccessful. The complex depositional history of the site prevented the calculation of reliable age models. A relative chronology for the full Manzi sequence was constructed, however, from the magnetostratigraphy of the deposit (N>R>N sequence). Isothermal thermoluminescence (ITL) dating of the upper Mode 3 layers also provided consistent results (???78 ka). A coarse but chronologically coherent sequence now exists for the Manzi section with the unconformity separating probable mid- or early Pleistocene deposits below from late Pleistocene deposits above. The results suggest Mode 1 technology in the Luangwa Valley may post-date the Oldowan in eastern and southern Africa. The dating programme has contributed to a clearer understanding of the geomorphological processes that have shaped the valley and

Co-expression of COX-2 and 5-LO in primary glioblastoma is associated with poor prognosis.

PubMed

Wang, Xingfu; Chen, Yupeng; Zhang, Sheng; Zhang, Lifeng; Liu, Xueyong; Zhang, Li; Li, Xiaoling; Chen, Dayang

2015-11-01

Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) are important factors in tumorigenesis and malignant progression; however, studies of their roles in glioblastoma have produced conflicting results. To define the frequencies of COX-2 and 5-LO expression and their correlation with clinicopathological features and prognosis, tumor tissues from 76 cases of newly diagnosed primary ordinary glioblastoma were examined for COX-2 and 5-LO expression by immunohistochemistry. The expression levels of COX-2 and 5-LO and the relationships between the co-expression of COX-2/5-LO and patient age and gender, edema index (EI), Karnofsky Performance Scale and overall survival (OS) were analyzed. COX-2 and 5-LO were expressed in 73.7 % (56/76) and 92.1 % (70/76) of the samples, respectively. Among the clinicopathological characteristics, only age (>60 years) exhibited a significant association with the high expression of COX-2. No statistically significant correlations were found in the 5-LO cohort. A significant positive correlation was revealed between the COX-2 and 5-LO scores (r = 0.374; p = 0.001). The elevated co-expression of COX-2 and 5-LO was observed primarily in the patients over the age of 60 years. Patients with a high expression of COX-2 had a significantly shorter OS (p < 0.01), whereas the immunoexpression of 5-LO was not associated with the OS of patients with glioblastoma. Survival analysis indicated that simultaneous high levels of COX-2 and 5-LO expression were significantly correlated with poor OS and, conversely, that a low/low expression pattern of these two proteins was significantly associated with better OS (p < 0.05). Moreover, the Cox multivariable proportional hazard model showed that a high expression of COX-2, high co-expression of COX-2 and 5-LO, and a high Ki-67 index were significant predictors of shorter OS in primary glioblastoma, independent of age, gender, EI, 5-LO expression and p53 status. The hazard ratios for OS were 2.347 (95 % CI 1

Temperature- and pressure-dependent infrared spectroscopy of 1-butyl-3-methylimidazolium trifluoromethanesulfonate: A dipolar coupling theory analysis

NASA Astrophysics Data System (ADS)

Burba, Christopher M.; Chang, Hai-Chou

2018-03-01

Continued growth and development of ionic liquids requires a thorough understanding of how cation and anion molecular structure defines the liquid structure of the materials as well as the various properties that make them technologically useful. Infrared spectroscopy is frequently used to assess molecular-level interactions among the cations and anions of ionic liquids because the intramolecular vibrational modes of the ions are sensitive to the local potential energy environments in which they reside. Thus, different interaction modes among the ions may lead to different spectroscopic signatures in the vibrational spectra. Charge organization present in ionic liquids, such as 1-butyl-3-methylimidazolium trifluoromethanesulfonate ([C4mim]CF3SO3), is frequently modeled in terms of a quasicrystalline structure. Highly structured quasilattices enable the dynamic coupling of vibrationally-induced dipole moments to produce optical dispersion and transverse optical-longitudinal optical (TO-LO) splitting of vibrational modes of the ionic liquid. According to dipolar coupling theory, the degree of TO-LO splitting is predicted to have a linear dependence on the number density of the ionic liquid. Both temperature and pressure will affect the number density of the ionic liquid and, therefore, the amount of TO-LO splitting for this mode. Therefore, we test these relationships through temperature- and pressure-dependent FT-IR spectroscopic studies of [C4mim]CF3SO3, focusing on the totally symmetric Ssbnd O stretching mode for the anion, νs(SO3). Increased temperature decreases the amount of TO-LO splitting for νs(SO3), whereas elevated pressure is found to increase the amount of band splitting. In both cases, the experimental observations follow the general predictions of dipolar coupling theory, thereby supporting the quasilattice model for this ionic liquid.

EETs Attenuate Ox-LDL-Induced LTB4 Production and Activity by Inhibiting p38 MAPK Phosphorylation and 5-LO/BLT1 Receptor Expression in Rat Pulmonary Arterial Endothelial Cells.

PubMed

Jiang, Jun-xia; Zhang, Shui-juan; Xiong, Yao-kang; Jia, Yong-liang; Sun, Yan-hong; Lin, Xi-xi; Shen, Hui-juan; Xie, Qiang-min; Yan, Xiao-feng

2015-01-01

Cytochrome P-450 epoxygenase (EPOX)-derived epoxyeicosatrienoic acids (EETs), 5-lipoxygenase (5-LO), and leukotriene B4 (LTB4), the product of 5-LO, all play a pivotal role in the vascular inflammatory process. We have previously shown that EETs can alleviate oxidized low-density lipoprotein (ox-LDL)-induced endothelial inflammation in primary rat pulmonary artery endothelial cells (RPAECs). Here, we investigated whether ox-LDL can promote LTB4 production through the 5-LO pathway. We further explored how exogenous EETs influence ox-LDL-induced LTB4 production and activity. We found that treatment with ox-LDL increased the production of LTB4 and further led to the expression and release of both monocyte chemoattractant protein-1 (MCP-1/CCL2) and intercellular adhesion molecule-1 (ICAM-1). All of the above ox-LDL-induced changes were attenuated by the presence of 11,12-EET and 14,15-EET, as these molecules inhibited the 5-LO pathway. Furthermore, the LTB4 receptor 1 (BLT1 receptor) antagonist U75302 attenuated ox-LDL-induced ICAM-1 and MCP-1/CCL2 expression and production, whereas LY255283, a LTB4 receptor 2 (BLT2 receptor) antagonist, produced no such effects. Moreover, in RPAECs, we demonstrated that the increased expression of 5-LO and BLT1 following ox-LDL treatment resulted from the activation of nuclear factor-κB (NF-κB) via the p38 mitogen-activated protein kinase (MAPK) pathway. Our results indicated that EETs suppress ox-LDL-induced LTB4 production and subsequent inflammatory responses by downregulating the 5-LO/BLT1 receptor pathway, in which p38 MAPK phosphorylation activates NF-κB. These results suggest that the metabolism of arachidonic acid via the 5-LO and EPOX pathways may present a mutual constraint on the physiological regulation of vascular endothelial cells.

EETs Attenuate Ox-LDL-Induced LTB4 Production and Activity by Inhibiting p38 MAPK Phosphorylation and 5-LO/BLT1 Receptor Expression in Rat Pulmonary Arterial Endothelial Cells

PubMed Central

Xiong, Yao-kang; Jia, Yong-liang; Sun, Yan-hong; Lin, Xi-xi; Shen, Hui-juan; Xie, Qiang-min; Yan, Xiao-feng

2015-01-01

Cytochrome P-450 epoxygenase (EPOX)-derived epoxyeicosatrienoic acids (EETs), 5-lipoxygenase (5-LO), and leukotriene B4 (LTB4), the product of 5-LO, all play a pivotal role in the vascular inflammatory process. We have previously shown that EETs can alleviate oxidized low-density lipoprotein (ox-LDL)-induced endothelial inflammation in primary rat pulmonary artery endothelial cells (RPAECs). Here, we investigated whether ox-LDL can promote LTB4 production through the 5-LO pathway. We further explored how exogenous EETs influence ox-LDL-induced LTB4 production and activity. We found that treatment with ox-LDL increased the production of LTB4 and further led to the expression and release of both monocyte chemoattractant protein-1 (MCP-1/CCL2) and intercellular adhesion molecule-1 (ICAM-1). All of the above ox-LDL-induced changes were attenuated by the presence of 11,12-EET and 14,15-EET, as these molecules inhibited the 5-LO pathway. Furthermore, the LTB4 receptor 1 (BLT1 receptor) antagonist U75302 attenuated ox-LDL-induced ICAM-1 and MCP-1/CCL2 expression and production, whereas LY255283, a LTB4 receptor 2 (BLT2 receptor) antagonist, produced no such effects. Moreover, in RPAECs, we demonstrated that the increased expression of 5-LO and BLT1 following ox-LDL treatment resulted from the activation of nuclear factor-κB (NF-κB) via the p38 mitogen-activated protein kinase (MAPK) pathway. Our results indicated that EETs suppress ox-LDL-induced LTB4 production and subsequent inflammatory responses by downregulating the 5-LO/BLT1 receptor pathway, in which p38 MAPK phosphorylation activates NF-κB. These results suggest that the metabolism of arachidonic acid via the 5-LO and EPOX pathways may present a mutual constraint on the physiological regulation of vascular endothelial cells. PMID:26035589

Diagnosing the Neutral Interstellar Gas Flow at 1 AU with IBEX-Lo

NASA Astrophysics Data System (ADS)

Möbius, E.; Kucharek, H.; Clark, G.; O'Neill, M.; Petersen, L.; Bzowski, M.; Saul, L.; Wurz, P.; Fuselier, S. A.; Izmodenov, V. V.; McComas, D. J.; Müller, H. R.; Alexashov, D. B.

2009-08-01

Every year in fall and spring the Interstellar Boundary Explorer (IBEX) will observe directly the interstellar gas flow at 1 AU over periods of several months. The IBEX-Lo sensor employs a powerful triple time-of-flight mass spectrometer. It can distinguish and image the O and He flow distributions in the northern fall and spring, making use of sensor viewing perpendicular to the Sun-pointing spin axis. To effectively image the narrow flow distributions IBEX-Lo has a high angular resolution quadrant in its collimator. This quadrant is employed selectively for the interstellar gas flow viewing in the spring by electrostatically shutting off the remainder of the aperture. The operational scenarios, the expected data, and the necessary modeling to extract the interstellar parameters and the conditions in the heliospheric boundary are described. The combination of two key interstellar species will facilitate a direct comparison of the pristine interstellar flow, represented by He, which has not been altered in the heliospheric boundary region, with a flow that is processed in the outer heliosheath, represented by O. The O flow distribution consists of a depleted pristine component and decelerated and heated neutrals. Extracting the latter so-called secondary component of interstellar neutrals will provide quantitative constraints for several important parameters of the heliosheath interaction in current global heliospheric models. Finding the fraction and width of the secondary component yields an independent value for the global filtration factor of species, such as O and H. Thus far filtration can only be inferred, barring observations in the local interstellar cloud proper. The direction of the secondary component will provide independent information on the interstellar magnetic field strength and orientation, which has been inferred from SOHO SWAN Ly- α backscattering observations and the two Voyager crossings of the termination shock.

Waveguide modes of 1D photonic crystals in a transverse magnetic field

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sylgacheva, D. A., E-mail: sylgacheva.darjja@physics.msu.ru; Khokhlov, N. E.; Kalish, A. N.

2016-11-15

We analyze waveguide modes in 1D photonic crystals containing layers magnetized in the plane. It is shown that the magnetooptical nonreciprocity effect emerges in such structures during the propagation of waveguide modes along the layers and perpendicularly to the magnetization. This effect involves a change in the phase velocity of the mode upon reversal of the direction of magnetization. Comparison of the effects in a nonmagnetic photonic crystal with an additional magnetic layer and in a photonic crystal with magnetic layers shows that the magnitude of this effect is several times larger in the former case in spite of themore » fact that the electromagnetic field of the modes in the latter case is localized in magnetic regions more strongly. This is associated with asymmetry of the dielectric layers contacting with the magnetic layer in the former case. This effect is important for controlling waveguide structure modes with the help of an external magnetic field.« less

Quadrature mixture LO suppression via DSW DAC noise dither

DOEpatents

Dubbert, Dale F [Cedar Crest, NM; Dudley, Peter A [Albuquerque, NM

2007-08-21

A Quadrature Error Corrected Digital Waveform Synthesizer (QECDWS) employs frequency dependent phase error corrections to, in effect, pre-distort the phase characteristic of the chirp to compensate for the frequency dependent phase nonlinearity of the RF and microwave subsystem. In addition, the QECDWS can employ frequency dependent correction vectors to the quadrature amplitude and phase of the synthesized output. The quadrature corrections cancel the radars' quadrature upconverter (mixer) errors to null the unwanted spectral image. A result is the direct generation of an RF waveform, which has a theoretical chirp bandwidth equal to the QECDWS clock frequency (1 to 1.2 GHz) with the high Spurious Free Dynamic Range (SFDR) necessary for high dynamic range radar systems such as SAR. To correct for the problematic upconverter local oscillator (LO) leakage, precision DC offsets can be applied over the chirped pulse using a pseudo-random noise dither. The present dither technique can effectively produce a quadrature DC bias which has the precision required to adequately suppress the LO leakage. A calibration technique can be employed to calculate both the quadrature correction vectors and the LO-nulling DC offsets using the radar built-in test capability.

Resonant Raman scattering study of BexZn1-xO thin films grown on sapphire by molecular beam epitaxy

NASA Astrophysics Data System (ADS)

Wang, Yu-Chao; Su, Long-Xing; Zhao, Yu; Liu, Jian-Feng; Shen, Zheng-Chuan; Feng, Yu-Hua; Wu, Tian-Zhun; Tang, Zi-Kang

2017-07-01

Resonance Raman spectra of BexZn1-xO alloy materials were studied using 325 nm Laser. The research showed that the Raman spectra of BexZn1-xO alloys presents a dual-mode vibration. Compare BexZn1-xO alloy with ZnO single crystal, the A1 (LO) phonon vibration mode of BexZn1-xO alloy moved to the larger wave number direction. The position of A1 (LO) phonon vibration modes of Be0.08Zn0.92O and Be0.12Zn0.88O was 580 cm-1 and 582 cm-1, respectively. In addition, the temperature-dependent Raman spectroscopy was employed for Be0.12Zn0.88O, and the phonon mode frequency shift with temperature was studied in detail. Finally, the stability of the polar and nonpolar BexZn1-xO alloy materials was studied using resonance Raman spectroscopy. The results showed that the A1 (LO) phonon mode frequency of polar BexZn1-xO alloy remained in the same position, while the nonpolar BexZn1-xO alloys moved nearly 3.5 cm-1 to larger direction after being placed in the air for two years. The reason may be that the stability of the nonpolar BexZn1-xO alloy is relatively poor upon interaction with molecule such as H2O, O2 in the air.

Pele Erupting on Lo

NASA Technical Reports Server (NTRS)

2001-01-01

This image of Jupiter's moon, lo, was taken by the Chandra X-Ray Observatory (CXO). Shown here is the most extreme example of the effect of tidal forces as Lo is being pulled by massive Jupiter on one side and by the outer moons Europa, Callisto, and Ganymede on the other. The opposing tidal forces alternately squeeze and stretch its interior, causing the solid surface to rise and fall by about 100 meters. The enormous amount of heat and pressure generated by the resulting friction creates colossal volcanoes and fractures on the surface of this moon.

Tolerance of the frequency deviation of LO sources at a MIMO system

NASA Astrophysics Data System (ADS)

Xiao, Jiangnan; Li, Xingying; Zhang, Zirang; Xu, Yuming; Chen, Long; Yu, Jianjun

2015-11-01

We analyze and simulate the tolerance of frequency offset at a W-band optical-wireless transmission system. The transmission system adopts optical polarization division multiplexing (PDM), and multiple-input multiple-output (MIMO) reception. The transmission signal adopts optical quadrature phase shift keying (QPSK) modulation, and the generation of millimeter-wave is based on the optical heterodyning technique. After 20-km single-mode fiber-28 (SMF-28) transmission, tens of Gb/s millimeter-wave signal is delivered. At the receiver, two millimeter-wave signals are down-converted into electrical intermediate-frequency (IF) signals in the analog domain by mixing with two electrical local oscillators (LOs) with different frequencies. We investigate the different frequency LO effect on the 2×2 MIMO system performance for the first time, finding that the process during DSP of implementing frequency offset estimation (FOE) before cascaded multi-modulus-algorithm (CMMA) equalization can get rid of the inter-channel interference (ICI) and improve system bit-error-ratio (BER) performance in this type of transmission system.

Gas6 Promotes Inflammatory (CCR2hiCX3CR1lo) Monocyte Recruitment in Venous Thrombosis.

PubMed

Laurance, Sandrine; Bertin, François-René; Ebrahimian, Talin; Kassim, Yusra; Rys, Ryan N; Lehoux, Stéphanie; Lemarié, Catherine A; Blostein, Mark D

2017-07-01

Coagulation and inflammation are inter-related. Gas6 (growth arrest-specific 6) promotes venous thrombosis and participates to inflammation through endothelial-innate immune cell interactions. Innate immune cells can provide the initiating stimulus for venous thrombus development. We hypothesize that Gas6 promotes monocyte recruitment during venous thrombosis. Deep venous thrombosis was induced in wild-type and Gas6-deficient (-/-) mice using 5% FeCl 3 and flow reduction in the inferior vena cava. Total monocyte depletion was achieved by injection of clodronate before deep venous thrombosis. Inflammatory monocytes were depleted using an anti-C-C chemokine receptor type 2 (CCR2) antibody. Similarly, injection of an anti-chemokine ligand 2 (CCL2) antibody induced CCL2 depletion. Flow cytometry and immunofluorescence were used to characterize the monocytes recruited to the thrombus. In vivo, absence of Gas6 was associated with a reduction of monocyte recruitment in both deep venous thrombosis models. Global monocyte depletion by clodronate leads to smaller thrombi in wild-type mice. Compared with wild type, the thrombi from Gas6 -/- mice contain less inflammatory (CCR2 hi CX 3 CR1 lo ) monocytes, consistent with a Gas6-dependent recruitment of this monocyte subset. Correspondingly, selective depletion of CCR2 hi CX 3 CR1 lo monocytes reduced the formation of venous thrombi in wild-type mice demonstrating a predominant role of the inflammatory monocytes in thrombosis. In vitro, the expression of both CCR2 and CCL2 were Gas6 dependent in monocytes and endothelial cells, respectively, impacting monocyte migration. Moreover, Gas6-dependent CCL2 expression and monocyte migration were mediated via JNK (c-Jun N-terminal kinase). This study demonstrates that Gas6 specifically promotes the recruitment of inflammatory CCR2 hi CX 3 CR1 lo monocytes through the regulation of both CCR2 and CCL2 during deep venous thrombosis. © 2017 American Heart Association, Inc.

Human CD34(lo)CD133(lo) fetal liver cells support the expansion of human CD34(hi)CD133(hi) hematopoietic stem cells.

PubMed

Yong, Kylie Su Mei; Keng, Choong Tat; Tan, Shu Qi; Loh, Eva; Chang, Kenneth Te; Tan, Thiam Chye; Hong, Wanjin; Chen, Qingfeng

2016-09-01

We have recently discovered a unique CD34(lo)CD133(lo) cell population in the human fetal liver (FL) that gives rise to cells in the hepatic lineage. In this study, we further characterized the biological functions of FL CD34(lo)CD133(lo) cells. Our findings show that these CD34(lo)CD133(lo) cells express markers of both endodermal and mesodermal lineages and have the capability to differentiate into hepatocyte and mesenchymal lineage cells by ex vivo differentiation assays. Furthermore, we show that CD34(lo)CD133(lo) cells express growth factors that are important for human hematopoietic stem cell (HSC) expansion: stem cell factor (SCF), insulin-like growth factor 2 (IGF2), C-X-C motif chemokine 12 (CXCL12), and factors in the angiopoietin-like protein family. Co-culture of autologous FL HSCs and allogenic HSCs derived from cord blood with CD34(lo)CD133(lo) cells supports and expands both types of HSCs.These findings are not only essential for extending our understanding of the HSC niche during the development of embryonic and fetal hematopoiesis but will also potentially benefit adult stem cell transplantations in clinics because expanded HSCs demonstrate the same capacity as primary cells to reconstitute the human immune system and mediate long-term hematopoiesis in vivo. Together, CD34(lo)CD133(lo) cells not only serve as stem/progenitor cells for liver development but are also an essential component of the HSC niche in the human FL.

Enhancing LoRaWAN Security through a Lightweight and Authenticated Key Management Approach.

PubMed

Sanchez-Iborra, Ramon; Sánchez-Gómez, Jesús; Pérez, Salvador; Fernández, Pedro J; Santa, José; Hernández-Ramos, José L; Skarmeta, Antonio F

2018-06-05

Luckily, new communication technologies and protocols are nowadays designed considering security issues. A clear example of this can be found in the Internet of Things (IoT) field, a quite recent area where communication technologies such as ZigBee or IPv6 over Low power Wireless Personal Area Networks (6LoWPAN) already include security features to guarantee authentication, confidentiality and integrity. More recent technologies are Low-Power Wide-Area Networks (LP-WAN), which also consider security, but present initial approaches that can be further improved. An example of this can be found in Long Range (LoRa) and its layer-two supporter LoRa Wide Area Network (LoRaWAN), which include a security scheme based on pre-shared cryptographic material lacking flexibility when a key update is necessary. Because of this, in this work, we evaluate the security vulnerabilities of LoRaWAN in the area of key management and propose different alternative schemes. Concretely, the application of an approach based on the recently specified Ephemeral Diffie⁻Hellman Over COSE (EDHOC) is found as a convenient solution, given its flexibility in the update of session keys, its low computational cost and the limited message exchanges needed. A comparative conceptual analysis considering the overhead of different security schemes for LoRaWAN is carried out in order to evaluate their benefits in the challenging area of LP-WAN.

Elastic-Plastic Finite Element Analysis of Fatigue Crack Growth in Mode 1 and Mode 2 Conditions

NASA Technical Reports Server (NTRS)

Nakagaki, M.; Atluri, S. N.

1978-01-01

Presented is an alternate cost-efficient and accurate elastic-plastic finite element procedure to analyze fatigue crack closure and its effects under general spectrum loading. Both Modes 1 and 2 type cycling loadings are considered. Also presented are the results of an investigation, using the newly developed procedure, of various factors that cause crack growth acceleration or retardation and delay effects under high-to-low, low-to-high, single overload, and constant amplitude type cyclic loading in a Mode 1 situation. Further, the results of an investigation of a centercracked panel under external pure shear (Mode 2) cyclic loading, of constant amplitude, are reported.

Investigation of the n  =  1 resistive wall modes in the ITER high-mode confinement

NASA Astrophysics Data System (ADS)

Zheng, L. J.; Kotschenreuther, M. T.; Valanju, P.

2017-06-01

The n  =  1 resistive wall mode (RWM) stability of ITER high-mode confinement is investigated with bootstrap current included for equilibrium, together with the rotation and diamagnetic drift effects for stability. Here, n is the toroidal mode number. We use the CORSICA code for computing the free boundary equilibrium and AEGIS code for stability. We find that the inclusion of bootstrap current for equilibrium is critical. It can reduce the local magnetic shear in the pedestal, so that the infernal mode branches can develop. Consequently, the n  =  1 modes become unstable without a stabilizing wall at a considerably lower beta limit, driven by the steep pressure gradient in the pedestal. Typical values of the wall position stabilize the ideal mode, but give rise to the ‘pedestal’ resistive wall modes. We find that the rotation can contribute a stabilizing effect on RWMs and the diamagnetic drift effects can further improve the stability in the co-current rotation case. But, generally speaking, the rotation stabilization effects are not as effective as the case without including the bootstrap current effects on equilibrium. We also find that the diamagnetic drift effects are actually destabilizing when there is a counter-current rotation.

Structural and dynamical properties of Bridgman-grown CdSexTe1-x (0

NASA Astrophysics Data System (ADS)

Talwar, Devki N.; Feng, Zhe Chuan; Lee, Jyh-Fu; Becla, P.

2013-04-01

Measurements of the Raman scattering and extended x-ray-absorption fine-structure (EXAFS) spectroscopy are reported on a series of Bridgman-grown zinc-blende CdTe1-xSex (0.35 ≥ x > 0.05) ternary alloys to empathize their lattice dynamical and structural properties. Low-temperature Raman spectra have revealed the classic CdTe-like (TO1, LO1) and CdSe-like (TO2, LO2) pairs of optical phonons. The composition-dependent peak positions of the LO2 modes exhibited shifts towards the higher-energy side, while those of the LO1 phonon frequencies have unveiled the slight redshifts. Detailed analyses of EXAFS data by using the first-principles bond orbital model have enabled us to estimate both the lattice relaxations and nearest-neighbor radial force constants around the Se/Te atoms in the CdTe/CdSe matrix. These results are methodically integrated in the “average t-matrix” formalism within the Green's-function theory for defining the impurity perturbations to comprehend the composition-dependent optical phonons in CdTe1-xSex alloys. Based on our comprehensive calculations of impurity modes in the low-composition regime x→ 0, we have assigned the weak phonon feature observed near ˜175 cm-1 in the low-temperature infrared reflectivity spectroscopy study to a SeTe localized vibrational mode.

Mode division multiplexing using an orbital angular momentum mode sorter and MIMO-DSP over a graded-index few-mode optical fibre

PubMed Central

Huang, Hao; Milione, Giovanni; Lavery, Martin P. J.; Xie, Guodong; Ren, Yongxiong; Cao, Yinwen; Ahmed, Nisar; An Nguyen, Thien; Nolan, Daniel A.; Li, Ming-Jun; Tur, Moshe; Alfano, Robert R.; Willner, Alan E.

2015-01-01

Mode division multiplexing (MDM)– using a multimode optical fiber’s N spatial modes as data channels to transmit N independent data streams – has received interest as it can potentially increase optical fiber data transmission capacity N-times with respect to single mode optical fibers. Two challenges of MDM are (1) designing mode (de)multiplexers with high mode selectivity (2) designing mode (de)multiplexers without cascaded beam splitting’s 1/N insertion loss. One spatial mode basis that has received interest is that of orbital angular momentum (OAM) modes. In this paper, using a device referred to as an OAM mode sorter, we show that OAM modes can be (de)multiplexed over a multimode optical fiber with higher than −15 dB mode selectivity and without cascaded beam splitting’s 1/N insertion loss. As a proof of concept, the OAM modes of the LP11 mode group (OAM−1,0 and OAM+1,0), each carrying 20-Gbit/s polarization division multiplexed and quadrature phase shift keyed data streams, are transmitted 5km over a graded-index, few-mode optical fibre. Channel crosstalk is mitigated using 4 × 4 multiple-input-multiple-output digital-signal-processing with <1.5 dB power penalties at a bit-error-rate of 2 × 10−3. PMID:26450398

Mode division multiplexing using an orbital angular momentum mode sorter and MIMO-DSP over a graded-index few-mode optical fibre.

PubMed

Huang, Hao; Milione, Giovanni; Lavery, Martin P J; Xie, Guodong; Ren, Yongxiong; Cao, Yinwen; Ahmed, Nisar; An Nguyen, Thien; Nolan, Daniel A; Li, Ming-Jun; Tur, Moshe; Alfano, Robert R; Willner, Alan E

2015-10-09

Mode division multiplexing (MDM)- using a multimode optical fiber's N spatial modes as data channels to transmit N independent data streams - has received interest as it can potentially increase optical fiber data transmission capacity N-times with respect to single mode optical fibers. Two challenges of MDM are (1) designing mode (de)multiplexers with high mode selectivity (2) designing mode (de)multiplexers without cascaded beam splitting's 1/N insertion loss. One spatial mode basis that has received interest is that of orbital angular momentum (OAM) modes. In this paper, using a device referred to as an OAM mode sorter, we show that OAM modes can be (de)multiplexed over a multimode optical fiber with higher than -15 dB mode selectivity and without cascaded beam splitting's 1/N insertion loss. As a proof of concept, the OAM modes of the LP11 mode group (OAM-1,0 and OAM+1,0), each carrying 20-Gbit/s polarization division multiplexed and quadrature phase shift keyed data streams, are transmitted 5km over a graded-index, few-mode optical fibre. Channel crosstalk is mitigated using 4 × 4 multiple-input-multiple-output digital-signal-processing with <1.5 dB power penalties at a bit-error-rate of 2 × 10(-3).

Mode division multiplexing using an orbital angular momentum mode sorter and MIMO-DSP over a graded-index few-mode optical fibre

NASA Astrophysics Data System (ADS)

Huang, Hao; Milione, Giovanni; Lavery, Martin P. J.; Xie, Guodong; Ren, Yongxiong; Cao, Yinwen; Ahmed, Nisar; An Nguyen, Thien; Nolan, Daniel A.; Li, Ming-Jun; Tur, Moshe; Alfano, Robert R.; Willner, Alan E.

2015-10-01

Mode division multiplexing (MDM)- using a multimode optical fiber’s N spatial modes as data channels to transmit N independent data streams - has received interest as it can potentially increase optical fiber data transmission capacity N-times with respect to single mode optical fibers. Two challenges of MDM are (1) designing mode (de)multiplexers with high mode selectivity (2) designing mode (de)multiplexers without cascaded beam splitting’s 1/N insertion loss. One spatial mode basis that has received interest is that of orbital angular momentum (OAM) modes. In this paper, using a device referred to as an OAM mode sorter, we show that OAM modes can be (de)multiplexed over a multimode optical fiber with higher than -15 dB mode selectivity and without cascaded beam splitting’s 1/N insertion loss. As a proof of concept, the OAM modes of the LP11 mode group (OAM-1,0 and OAM+1,0), each carrying 20-Gbit/s polarization division multiplexed and quadrature phase shift keyed data streams, are transmitted 5km over a graded-index, few-mode optical fibre. Channel crosstalk is mitigated using 4 × 4 multiple-input-multiple-output digital-signal-processing with <1.5 dB power penalties at a bit-error-rate of 2 × 10-3.

Design and fabrication of a 1-DOF drive mode and 2-DOF sense mode micro-gyroscope using SU-8 based UV-LIGA process

NASA Astrophysics Data System (ADS)

Verma, Payal; Juneja, Sucheta; Savelyev, Dmitry A.; Khonina, Svetlana N.; Gopal, Ram

2016-04-01

This paper presents design and fabrication of a 1-DOF (degree-of-freedom) drive mode and 2-DOF sense mode micro-gyroscope. It is an inherently robust structure and offers a high sense frequency bandwidth. The proposed design utilizes resonance of the1-DOF drive mode oscillator and employs dynamic amplification concept in sense modes to increase the sensitivity while maintaining robustness. The 2-DOF in the sense direction renders the device immune to process imperfections and environmental effects. The design is simulated using FEA software (CoventorWare®). The device is designed considering process compatibility with SU-8 based UV-LIGA process, which is an economical fabrication technique. The complete fabrication process is presented along with SEM images of the fabricated device. The device has 9 µm thick Nickel as the key structural layer with an overall reduced key structure size of 2.2 mm by 2.1 mm.

Notch1 inhibition alters the CD44hi/CD24lo population and reduces the formation of brain metastases from breast cancer.

PubMed

McGowan, Patricia M; Simedrea, Carmen; Ribot, Emeline J; Foster, Paula J; Palmieri, Diane; Steeg, Patricia S; Allan, Alison L; Chambers, Ann F

2011-07-01

Brain metastasis from breast cancer is an increasingly important clinical problem. Here we assessed the role of CD44(hi)/CD24(lo) cells and pathways that regulate them, in an experimental model of brain metastasis. Notch signaling (mediated by γ-secretase) has been shown to contribute to maintenance of the cancer stem cell (CSC) phenotype. Cells sorted for a reduced stem-like phenotype had a reduced ability to form brain metastases compared with unsorted or CD44(hi)/CD24(lo) cells (P < 0.05; Kruskal-Wallis). To assess the effect of γ-secretase inhibition, cells were cultured with DAPT and the CD44/CD24 phenotypes quantified. 231-BR cells with a CD44(hi)/CD24(lo) phenotype was reduced by about 15% in cells treated with DAPT compared with DMSO-treated or untreated cells (P = 0.001, ANOVA). In vivo, mice treated with DAPT developed significantly fewer micro- and macrometastases compared with vehicle treated or untreated mice (P = 0.011, Kruskal-Wallis). Notch1 knockdown reduced the expression of CD44(hi)/CD24(lo) phenotype by about 20%. In vitro, Notch1 shRNA resulted in a reduction in cellular growth at 24, 48, and 72 hours time points (P = 0.033, P = 0.002, and P = 0.009, ANOVA) and about 60% reduction in Matrigel invasion was observed (P < 0.001, ANOVA). Cells transfected with shNotch1 formed significantly fewer macrometastases and micrometastases compared with scrambled shRNA or untransfected cells (P < 0.001; Kruskal-Wallis). These data suggest that the CSC phenotype contributes to the development of brain metastases from breast cancer, and this may arise in part from increased Notch activity. ©2011 AACR.

The Sublime Corpse in Gertrudis Gomez de Avellaneda's Women's Journal "Album Cubano de lo Bueno y lo Bello" (1860)

ERIC Educational Resources Information Center

LaGreca, Nancy

2009-01-01

This article examines Gertrudis Gomez de Avellaneda's choice to include articles depicting the advanced decay of cadavers, which are simultaneously horrible and awesome, in her women's periodical "Album Cubano de lo Bueno y lo Bello". Background on Avellaneda's biography, women's print culture, and theories of the sublime provide a frame for the…

Inhibition of 12/15-LO ameliorates CVB3-induced myocarditis by activating Nrf2.

PubMed

Ai, Feng; Zheng, Jiayong; Zhang, Yanwei; Fan, Taibing

2017-06-25

Cardiac 12/15-lipoxygenase (12/15-LO) was reported to be markedly up-regulated and involved in the development of heart failure. Nuclear factor E2-related factor 2 (Nrf2) plays anti-inflammatory and anti-oxidation roles in response to oxidative stress. However, the role of 12/15-LO in viral myocarditis (VMC) and its underlying molecular mechanism have not yet been elucidated. Here, we demonstrated that 12/15-LO was up-regulated and Nrf2 was down-regulated in coxsackievirus B3 (CVB3)-infected mice and cardiac myocytes. Baicalein, the specific inhibitor of 12/15-LO, was employed to investigate the role of 12/15-LO and its underlying mechanism in VMC. We found that baicalein treatment alleviated CVB3-induced VMC mouse models, as demonstrated by less inflammatory lesions in the heart tissues and less CK-MB level. Moreover, baicalein treatment attenuated CVB3-induced inflammatory cytokine production and oxidative stress. Mechanistic analysis suggested that baicalein treatment relieved CVB3-induced reduction of Nrf2 and heme oxygenase-1 (HO-1) expressions. Taken together, our study indicated that inhibition of 12/15-LO ameliorates VMC by activating Nrf2, providing a new therapeutic strategy for the therapy of VMC. Copyright © 2017 Elsevier B.V. All rights reserved.

A Network Access Control Framework for 6LoWPAN Networks

PubMed Central

Oliveira, Luís M. L.; Rodrigues, Joel J. P. C.; de Sousa, Amaro F.; Lloret, Jaime

2013-01-01

Low power over wireless personal area networks (LoWPAN), in particular wireless sensor networks, represent an emerging technology with high potential to be employed in critical situations like security surveillance, battlefields, smart-grids, and in e-health applications. The support of security services in LoWPAN is considered a challenge. First, this type of networks is usually deployed in unattended environments, making them vulnerable to security attacks. Second, the constraints inherent to LoWPAN, such as scarce resources and limited battery capacity, impose a careful planning on how and where the security services should be deployed. Besides protecting the network from some well-known threats, it is important that security mechanisms be able to withstand attacks that have not been identified before. One way of reaching this goal is to control, at the network access level, which nodes can be attached to the network and to enforce their security compliance. This paper presents a network access security framework that can be used to control the nodes that have access to the network, based on administrative approval, and to enforce security compliance to the authorized nodes. PMID:23334610

In vitro characterization of CD133lo cancer stem cells in Retinoblastoma Y79 cell line.

PubMed

Nair, Rohini M; Balla, Murali Ms; Khan, Imran; Kalathur, Ravi Kiran Reddy; Kondaiah, Paturu; Vemuganti, Geeta K

2017-11-21

Retinoblastoma (Rb), the most common childhood intraocular malignant tumor, is reported to have cancer stem cells (CSCs) similar to other tumors. Our previous investigation in primary tumors identified the small sized cells with low CD133 (Prominin-1) and high CD44 (Hyaluronic acid receptor) expression to be putative Rb CSCs using flow cytometry (FSC lo /SSC lo /CD133 lo /CD44 hi ). With this preliminary data, we have now utilized a comprehensive approach of in vitro characterization of Y79 Rb cell line following CSC enrichment using CD133 surface marker and subsequent validation to confirm the functional properties of CSCs. The cultured Rb Y79 cells were evaluated for surface markers by flow cytometry and CD133 sorted cells (CD133 lo /CD133 hi ) were compared for CSC characteristics by size/percentage, cell cycle assay, colony formation assay, differentiation, Matrigel transwell invasion assay, cytotoxicity assay, gene expression using microarray and validation by semi-quantitative PCR. Rb Y79 cell line shared the profile (CD133, CD90, CXCR4 and ABCB1) of primary tumors except for CD44 expression. The CD133 lo cells (16.1 ± 0.2%) were FSC lo /SSC lo , predominantly within the G0/G1 phase, formed larger and higher number of colonies with ability to differentiate to CD133 hi cells, exhibited increased invasive potential in a matrigel transwell assay (p < 0.05) and were resistant to Carboplatin treatment (p < 0.001) as compared to CD133 hi cells. The CD133 lo cells showed higher expression of several embryonic stem cell genes (HOXB2, HOXA9, SALL1, NANOG, OCT4, LEFTY), stem cells/progenitor genes (MSI2, BMI1, PROX1, ABCB1, ABCB5, ABCG2), and metastasis related gene- MACC1, when compared to the CD133 hi cells. This study validates the observation from our earlier primary tumor study that CSC properties in Rb Y79 cell line are endowed within the CD133 lo population, evident by their characteristics- i.e. small sized, dormant in nature, increased colony forming

Flux-driven algebraic damping of m = 1 diocotron mode

NASA Astrophysics Data System (ADS)

Chim, Chi Yung; O'Neil, Thomas M.

2016-07-01

Recent experiments with pure electron plasmas in a Malmberg-Penning trap have observed the algebraic damping of m = 1 diocotron modes. Transport due to small field asymmetries produces a low density halo of electrons moving radially outward from the plasma core, and the mode damping begins when the halo reaches the resonant radius r = Rw at the wall of the trap. The damping rate is proportional to the flux of halo particles through the resonant layer. The damping is related to, but distinct from, spatial Landau damping, in which a linear wave-particle resonance produces exponential damping. This paper explains with analytic theory the new algebraic damping due to particle transport by both mobility and diffusion. As electrons are swept around the "cat's eye" orbits of the resonant wave-particle interaction, they form a dipole (m = 1) density distribution. From this distribution, the electric field component perpendicular to the core displacement produces E × B-drift of the core back to the axis, that is, damps the m = 1 mode. The parallel component produces drift in the azimuthal direction, that is, causes a shift in the mode frequency.

Nonlinear mode decomposition: A noise-robust, adaptive decomposition method

NASA Astrophysics Data System (ADS)

Iatsenko, Dmytro; McClintock, Peter V. E.; Stefanovska, Aneta

2015-09-01

The signals emanating from complex systems are usually composed of a mixture of different oscillations which, for a reliable analysis, should be separated from each other and from the inevitable background of noise. Here we introduce an adaptive decomposition tool—nonlinear mode decomposition (NMD)—which decomposes a given signal into a set of physically meaningful oscillations for any wave form, simultaneously removing the noise. NMD is based on the powerful combination of time-frequency analysis techniques—which, together with the adaptive choice of their parameters, make it extremely noise robust—and surrogate data tests used to identify interdependent oscillations and to distinguish deterministic from random activity. We illustrate the application of NMD to both simulated and real signals and demonstrate its qualitative and quantitative superiority over other approaches, such as (ensemble) empirical mode decomposition, Karhunen-Loève expansion, and independent component analysis. We point out that NMD is likely to be applicable and useful in many different areas of research, such as geophysics, finance, and the life sciences. The necessary matlab codes for running NMD are freely available for download.

Symmetry-adapted tight-binding calculations of the totally symmetric A1 phonons of single-walled carbon nanotubes and their resonant Raman intensity

NASA Astrophysics Data System (ADS)

Popov, Valentin N.; Lambin, Philippe

2007-03-01

The atomistic calculations of the physical properties of perfect single-walled carbon nanotubes based on the use of the translational symmetry of the nanotubes face increasing computational difficulties for most of the presently synthesized nanotubes with up to a few thousand atoms in the unit cell. This difficulty can be circumvented by use of the helical symmetry of the nanotubes and a two-atom unit cell. We present the results of such symmetry-adapted tight-binding calculations of the totally symmetric A1 phonons (the RBM and the G-band modes) and their resonant Raman intensity for several hundred nanotubes. In particular, we show that (1) the frequencies and the resonant Raman intensity of the RBM and the G-band modes show diameter and chirality dependence and family patterns, (2) the strong electron- A1LO phonon interactions in metallic nanotubes lead to Kohn anomalies at the zone center, (3) the G-band consists of a subband due to A1LO phonons of semiconducting tubes centered at ∼1593 cm -1, a subband of A1TO phonons at ∼1570 cm -1, and a subband of A1LO phonons of metallic tubes at ∼1540 cm -1. The latter prediction confirms previous theoretical results but disagrees with the commonly adopted assignment of the G-band features.

A Simultaneous Discovery: The Case of Johannes Stark and Antonino Lo Surdo

NASA Astrophysics Data System (ADS)

Leone, Matteo; Paoletti, Alessandro; Robotti, Nadia

2004-09-01

In 1913 the German physicist Johannes Stark (1874 1957) and the Italian physicist Antonino Lo Surdo (1880 1949)discovered virtually simultaneously and independently that hydrogen spectral lines are split into components by an external electric field. Both of their discoveries ensued from studies on the same phenomenon, the Doppler effect in canal rays, but they arose in different theoretical contexts. Stark had been working within the context of the emerging quantum theory, following a research program aimed at studying the effect of an electric field on spectral lines. Lo Surdo had been working within the context of the classical theory, and his was an accidental discovery. Both discoveries, however, played important roles in the history of physics: Stark’s discovery contributed to the establishment of both the old and the new quantum theories; Lo Surdo’s discovery led Antonio Garbasso (1871 1933)to introduce research on the quantum theory into Italian physics. Ironically, soon after their discoveries, both Stark and Lo Surdo rejected developments in modern physics and allied themselves with the political and racial programs of Hitler and Mussolini.

Aggregation of LoD 1 building models as an optimization problem

NASA Astrophysics Data System (ADS)

Guercke, R.; Götzelmann, T.; Brenner, C.; Sester, M.

3D city models offered by digital map providers typically consist of several thousands or even millions of individual buildings. Those buildings are usually generated in an automated fashion from high resolution cadastral and remote sensing data and can be very detailed. However, not in every application such a high degree of detail is desirable. One way to remove complexity is to aggregate individual buildings, simplify the ground plan and assign an appropriate average building height. This task is computationally complex because it includes the combinatorial optimization problem of determining which subset of the original set of buildings should best be aggregated to meet the demands of an application. In this article, we introduce approaches to express different aspects of the aggregation of LoD 1 building models in the form of Mixed Integer Programming (MIP) problems. The advantage of this approach is that for linear (and some quadratic) MIP problems, sophisticated software exists to find exact solutions (global optima) with reasonable effort. We also propose two different heuristic approaches based on the region growing strategy and evaluate their potential for optimization by comparing their performance to a MIP-based approach.

Determination of Oversulphated Chondroitin Sulphate and Dermatan Sulphate in unfractionated heparin by (1)H-NMR - Collaborative study for quantification and analytical determination of LoD.

PubMed

McEwen, I; Mulloy, B; Hellwig, E; Kozerski, L; Beyer, T; Holzgrabe, U; Wanko, R; Spieser, J-M; Rodomonte, A

2008-12-01

Oversulphated Chondroitin Sulphate (OSCS) and Dermatan Sulphate (DS) in unfractionated heparins can be identified by nuclear magnetic resonance spectrometry (NMR). The limit of detection (LoD) of OSCS is 0.1% relative to the heparin content. This LoD is obtained at a signal-to-noise ratio (S/N) of 2000:1 of the heparin methyl signal. Quantification is best obtained by comparing peak heights of the OSCS and heparin methyl signals. Reproducibility of less than 10% relative standard deviation (RSD) has been obtained. The accuracy of quantification was good.

An inductorless active mixer using stacked nMOS/pMOS configuration and LO shaping technique

NASA Astrophysics Data System (ADS)

Guo, Benqing; Chen, Jun; Wang, Xuebing; Chen, Hongpeng

2018-04-01

In this paper, a CMOS active down-conversion mixer is presented for wideband applications. Specifically, a LO generation chain is suggested to convert AC LO signal to shaped trapezoid burst, which reduces the sinusoidal LO power level requirement by the mixer. The current-reuse technique by stacked nMOS/pMOS architecture is used to save the power consumption of the circuit. Moreover, this complementary configuration is also employed to compensate second-order nonlinearity of the circuit. Implemented in a 0.18-μm CMOS process, post-simulations show that, driven by only ‑10 dBm sinusoidal LO signal, the proposed inductorless mixer provides a maximal conversion gain of 15.7 dB and a noise figure (NF) of 9.1-12 dB across RF input frequency range 0.5-1.6 GHz. The IIP3 and IP1dB of 3.5 dBm and ‑4.8 dBm are obtained, respectively. The mixer core only consumes 3.6 mW from a 1.8-V supply.

Adhesive performance of a multi-mode adhesive system: 1-year in vitro study.

PubMed

Marchesi, Giulio; Frassetto, Andrea; Mazzoni, Annalisa; Apolonio, Fabianni; Diolosà, Marina; Cadenaro, Milena; Di Lenarda, Roberto; Pashley, David H; Tay, Franklin; Breschi, Lorenzo

2014-05-01

The aim of this study was to investigate the adhesive stability over time of a multi-mode one-step adhesive applied using different bonding techniques on human coronal dentine. The hypotheses tested were that microtensile bond strength (μTBS), interfacial nanoleakage expression and matrix metalloproteinases (MMPs) activation are not affected by the adhesive application mode (following the use of self-etch technique or with the etch-and-rinse technique on dry or wet dentine) or by ageing for 24h, 6 months and 1year in artificial saliva. Human molars were cut to expose middle/deep dentine and assigned to one of the following bonding systems (N=15): (1) Scotchbond Universal (3M ESPE) self-etch mode, (2) Scotchbond Universal etch-and-rinse technique on wet dentine, (3) Scotchbond Universal etch-and-rinse technique on dry dentine, and (4) Prime&Bond NT (Dentsply De Trey) etch-and-rinse technique on wet dentine (control). Specimens were processed for μTBS test in accordance with the non-trimming technique and stressed to failure after 24h, 6 months or 1 year. Additional specimens were processed and examined to assay interfacial nanoleakage and MMP expression. At baseline, no differences between groups were found. After 1 year of storage, Scotchbond Universal applied in the self-etch mode and Prime&Bond NT showed higher μTBS compared to the other groups. The lowest nanoleakage expression was found for Scotchbond Universal applied in the self-etch mode, both at baseline and after storage. MMPs activation was found after application of each tested adhesive. The results of this study support the use of the self-etch approach for bonding the tested multi-mode adhesive system to dentine due to improved stability over time. Improved bonding effectiveness of the tested universal adhesive system on dentine may be obtained if the adhesive is applied with the self-etch approach. Copyright © 2014 Elsevier Ltd. All rights reserved.

Characterisation of a LoVo subline resistant to a benzoyl mustard derivative of distamycin A (FCE 24517).

PubMed Central

Capolongo, L.; Melegaro, G.; Broggini, M.; Mongelli, N.; Grandi, M.

1993-01-01

Human colon adenocarcinoma cells (LoVo) resistant to the new antitumor agent FCE 24517 [benzoyl-mustard derivative of distamycin A] (LoVo/24517) are resistant to the selecting agent and related molecules as well as to vinblastine, with marginal or no resistance to other antitumour drugs. Treatment with verapamil, tamoxifen, nicergoline or cyclosporin A only partially restores the activity of FCE 24517 against LoVo/24517 cells. Such results suggest that resistance mechanisms possible specific for this class of compounds are operating. Images Figure 2 PMID:8105866

The Physical Constraints on a New LoBAL QSO at z = 4.82

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yi, Weimin; Bai, Jin-Ming; Green, Richard

Very few low-ionization broad absorption line (LoBAL) QSOs have been found at high redshifts, to date. One high-redshift LoBAL QSO, J0122+1216, was recently discovered by the Lijiang 2.4 m Telescope, with an initial redshift determination of 4.76. Aiming to investigate its physical properties, we carried out follow-up observations in the optical and near-IR spectroscopy. Near-IR spectra from UKIRT and P200 confirm that it is a LoBAL, with a new redshift determination of 4.82 ± 0.01 based on the Mg ii emission-line. The new Mg ii redshift determination reveals strong blueshifts and asymmetry of the high-ionization emission lines. We estimate amore » black hole mass of ∼2.3 × 10{sup 9} M {sub ⊙} and Eddington ratio of ∼1.0 according to the empirical Mg ii-based single-epoch relation and bolometric correction factor. It is possible that strong outflows are the result of an extreme quasar environment driven by the high Eddington ratio. A lower limit on the outflowing kinetic power (>0.9% L {sub Edd}) is derived from both emission and absorption lines, indicating that these outflows play a significant role in the feedback process that regulates the growth of its black hole, as well as host galaxy evolution.« less

15-LO/15-HETE mediated vascular adventitia fibrosis via p38 MAPK-dependent TGF-β.

PubMed

Zhang, Li; Li, Yumei; Chen, Minggang; Su, Xiaojie; Yi, Dan; Lu, Ping; Zhu, Daling

2014-02-01

15-Lipoxygenase/15-hydroxyeicosatetraenoic acid (15-LO/15-HETE) is known to modulate pulmonary vascular medial hypertrophy and intimal endothelial cells migration and angiogenesis after hypoxia. However, it is unclear whether 15-HETE affects the adventitia of the pulmonary arterial wall. We performed immunohistochemistry, adventitia fibrosis, pulmonary artery fibroblasts phenotype and extracellular matrix (ECM) deposition to determine the role of 15-HETE in hypoxia-induced pulmonary vascular adventitia remodeling. Our studies showed that O2 deprivation induced adventitia hypertrophy of pulmonary arteries with ECM accumulation in both humans with pulmonary arterial hypertension and hypoxic rats. Hypoxia induced 15-LO expression in adventitia. With the inhibitor, NDGA depressed the hypoxia induced ECM deposition and 15-LO production in hypoxic rats. Hypoxia up-regulated the expression of α-SMA, type-Ia collagen and fibronectin in cultured fibroblasts, which seemed to be due to the increased 15-LO/15-HETE. Exogenous 15-HETE mediated the ECM and phenotypic alterations of the fibroblasts as well. The 15-LO/15-HETE induced adventitia fibrosis and fibroblasts phenotypic alterations depended on signaling of the transforming growth factor-β1 (TGF-β1)/Smad2/3 pathway. P38 mitogen-activated protein kinase (p38 MAPKs) was likely to mediate 15-LO induced TGF-β1 and Smad2/3 activation after hypoxia. The results suggest that adventitia fibrosis is an important event in the hypoxia induced pulmonary arterial remodeling, which relies on 15-LO/15-HETE induced p38 MAPK-dependent TGF-β1/Smad2/3 intracellular signaling systems. © 2013 Wiley Periodicals, Inc.

Effect of API-1 and FR180204 on cell proliferation and apoptosis in human DLD-1 and LoVo colorectal cancer cells

PubMed Central

Saglam, Atiye Seda Yar; Alp, Ebru; Elmazoglu, Zubeyir; Menevse, Emine Sevda

2016-01-01

The activation of the phosphatidylinositol-3 kinase/v-akt murine thymoma viral oncogene homolog (Akt) and mitogen activated protein kinase kinase/extracellular signal-regulated kinase (ERK) pathways are implicated in the majority of cancers. Selective inhibition of Akt and ERK represents a potential approach for cancer therapy. Therefore, the present study aimed to investigate the apoptotic and anti-proliferative effects of the novel and selective Akt inhibitor 4-amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide (API-1) and selective ERK1/2 inhibitor FR180204 (FR) alone and in combination on colorectal cancer (CRC) cells (DLD-1 and LoVo). In addition, the effects of API-1 and FR on Akt and ERK signaling pathways were also investigated. The effects of the agents on DLD-1 and LoVo cells were evaluated in terms of cell viability, cytotoxicity, DNA synthesis rate, DNA fragmentation and caspase-3 activity levels. In addition, quantitative reverse transcription-polymerase chain reaction and western blot analysis were performed to examine relevant mRNA and protein levels. The present study observed that the combination of FR with API-1 resulted in significant apoptosis and cytotoxicity compared with any single agent alone in a time-dependent manner in these cells. Also, treatment with FR and API-1 in combination decreased the expression levels of B-cell lymphoma-2 (BCL2), Bcl-2-like1, cyclin D1 and cMYC, and increased the expression levels of BCL2-associated X protein and BCL2 antagonist/killer via phosphorylated Akt and phosphorylated ERK1/2 downregulation. The combination of Akt and ERK1/2 inhibitors resulted in enhanced apoptotic and anti-proliferative effects against CRC cells. The present study hypothesizes that the combination of FR and API-1 in CRC cells may contribute toward potential anti-carcinogenic effects. Additional analyses using other cancer cell lines and animal models are required to confirm these findings in vitro and in

Effect of API-1 and FR180204 on cell proliferation and apoptosis in human DLD-1 and LoVo colorectal cancer cells.

PubMed

Saglam, Atiye Seda Yar; Alp, Ebru; Elmazoglu, Zubeyir; Menevse, Emine Sevda

2016-10-01

The activation of the phosphatidylinositol-3 kinase/v-akt murine thymoma viral oncogene homolog (Akt) and mitogen activated protein kinase kinase/extracellular signal-regulated kinase (ERK) pathways are implicated in the majority of cancers. Selective inhibition of Akt and ERK represents a potential approach for cancer therapy. Therefore, the present study aimed to investigate the apoptotic and anti-proliferative effects of the novel and selective Akt inhibitor 4-amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide (API-1) and selective ERK1/2 inhibitor FR180204 (FR) alone and in combination on colorectal cancer (CRC) cells (DLD-1 and LoVo). In addition, the effects of API-1 and FR on Akt and ERK signaling pathways were also investigated. The effects of the agents on DLD-1 and LoVo cells were evaluated in terms of cell viability, cytotoxicity, DNA synthesis rate, DNA fragmentation and caspase-3 activity levels. In addition, quantitative reverse transcription-polymerase chain reaction and western blot analysis were performed to examine relevant mRNA and protein levels. The present study observed that the combination of FR with API-1 resulted in significant apoptosis and cytotoxicity compared with any single agent alone in a time-dependent manner in these cells. Also, treatment with FR and API-1 in combination decreased the expression levels of B-cell lymphoma-2 (BCL2), Bcl-2-like1, cyclin D1 and cMYC, and increased the expression levels of BCL2-associated X protein and BCL2 antagonist/killer via phosphorylated Akt and phosphorylated ERK1/2 downregulation. The combination of Akt and ERK1/2 inhibitors resulted in enhanced apoptotic and anti-proliferative effects against CRC cells. The present study hypothesizes that the combination of FR and API-1 in CRC cells may contribute toward potential anti-carcinogenic effects. Additional analyses using other cancer cell lines and animal models are required to confirm these findings in vitro and in

A 12.1-W SESAM mode-locked Yb:YAG thin disk laser

NASA Astrophysics Data System (ADS)

Yingnan, Peng; Zhaohua, Wang; Dehua, Li; Jiangfeng, Zhu; Zhiyi, Wei

2016-05-01

Pumped by a 940 nm fiber-coupled diode laser, a passively mode-locked Yb:YAG thin disk oscillator was demonstrated with a semiconductor saturable absorber mirror (SESAM). 12.1 W mode-locked pulses were obtained with pulse duration of 698 fs at the repetition rate of 57.43 MHz. Measurement showed that the beam quality was close to the diffraction limit. Project supported by the National Key Basic Research Program of China (Grant No. 2013CB922402), the National Major Instrument Program of China (Grant No. 2012YQ120047), and the National Natural Science Foundation of China (Grant No. 61210017).

Experimental results for a 1.5 MW, 110 GHz gyrotron oscillator with reduced mode competition

NASA Astrophysics Data System (ADS)

Choi, E. M.; Marchewka, C. D.; Mastovsky, I.; Sirigiri, J. R.; Shapiro, M. A.; Temkin, R. J.

2006-02-01

A new result from a 110GHz gyrotron at MIT is reported with an output power of 1.67MW and an efficiency of 42% when operated at 97kV and 41A for 3μs pulses in the TE22,6 mode. These results are a major improvement over results obtained with an earlier cavity design, which produced 1.43MW of power at 37% efficiency. These new results were obtained using a cavity with a reduced output taper angle and a lower ohmic loss when compared with the earlier cavity. The improved operation is shown experimentally to be the result of reduced mode competition from the nearby TE19,7 mode. The reduced mode competition agrees well with an analysis of the startup scenario based on starting current simulations. The present results should prove useful in planning long pulse and CW versions of the 110GHz gyrotron.

Impact of velocity space distribution on hybrid kinetic-magnetohydrodynamic simulation of the (1,1) mode

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Charlson C.

2008-07-15

Numeric studies of the impact of the velocity space distribution on the stabilization of (1,1) internal kink mode and excitation of the fishbone mode are performed with a hybrid kinetic-magnetohydrodynamic model. These simulations demonstrate an extension of the physics capabilities of NIMROD[C. R. Sovinec et al., J. Comput. Phys. 195, 355 (2004)], a three-dimensional extended magnetohydrodynamic (MHD) code, to include the kinetic effects of an energetic minority ion species. Kinetic effects are captured by a modification of the usual MHD momentum equation to include a pressure tensor calculated from the {delta}f particle-in-cell method [S. E. Parker and W. W. Lee,more » Phys. Fluids B 5, 77 (1993)]. The particles are advanced in the self-consistent NIMROD fields. We outline the implementation and present simulation results of energetic minority ion stabilization of the (1,1) internal kink mode and excitation of the fishbone mode. A benchmark of the linear growth rate and real frequency is shown to agree well with another code. The impact of the details of the velocity space distribution is examined; particularly extending the velocity space cutoff of the simulation particles. Modestly increasing the cutoff strongly impacts the (1,1) mode. Numeric experiments are performed to study the impact of passing versus trapped particles. Observations of these numeric experiments suggest that assumptions of energetic particle effects should be re-examined.« less

Characterization of Mode 1 and Mode 2 delamination growth and thresholds in graphite/peek composites

NASA Technical Reports Server (NTRS)

Martin, Roderick H.; Murri, Gretchen B.

1988-01-01

Composite materials often fail by delamination. The onset and growth of delamination in AS4/PEEK, a tough thermoplastic matrix composite, was characterized for mode 1 and mode 2 loadings, using the Double Cantilever Beam (DCB) and the End Notched Flexure (ENF) test specimens. Delamination growth per fatigue cycle, da/dN, was related to strain energy release rate, G, by means of a power law. However, the exponents of these power laws were too large for them to be adequately used as a life prediction tool. A small error in the estimated applied loads could lead to large errors in the delamination growth rates. Hence strain energy release rate thresholds, G sub th, below which no delamination would occur were also measured. Mode 1 and 2 threshold G values for no delamination growth were found by monitoring the number of cycles to delamination onset in the DCB and ENF specimens. The maximum applied G for which no delamination growth had occurred until at least 1,000,000 cycles was considered the threshold strain energy release rate. Comments are given on how testing effects, facial interference or delamination front damage, may invalidate the experimental determination of the constants in the expression.

Large amplitude m=1 diocotron mode measurements in the Electron Diffusion Gauge experiment

NASA Astrophysics Data System (ADS)

Jenkins, Thomas G.; Morrison, Kyle A.; Davidson, Ronald C.; Paul, Stephen F.

2002-01-01

Smaller-diameter pure electron plasmas are generated in the Electron Diffusion Gauge (EDG) using a thoriated tungsten filament wound into a spiral shape with an outer diameter which is 1/4 of the trap wall diameter. The m=1 diocotron mode is excited in the plasma by means of the resistive-wall instability, using a resistor-relay circuit which allows the mode to be induced at various initial amplitudes. The dynamics of this mode may be predicted using linear theory when the amplitude is small. However, it has been observed [e.g., Fine et al., Phys. Rev. Lett. 63, 2232 (1989)] [1] that at larger amplitudes the frequency of this mode (relative to the small-amplitude frequency) exhibits a quadratic dependence on the mode amplitude. In this paper, the frequency shift and nonlinear dynamics of the m=1 diocotron mode in the EDG device are investigated.

Flux-driven algebraic damping of m = 1 diocotron mode

NASA Astrophysics Data System (ADS)

Chim, Chi Yung; O'Neil, Thomas

2015-11-01

Recent experiments with pure electron plasmas in a Malmberg-Penning trap have observed the algebraic damping of m = 1 diocotron modes. Transport due to small field asymmetries produce a low density halo of electrons moving radially outward from the plasma core, and the mode damping begins when the halo reaches the resonant radius rres, where f = mfE × B (rres) . The damping rate is proportional to the flux of halo particles through the resonant layer. The damping is related to, but distinct from spatial Landau damping, in which a linear wave-particle resonance produces exponential damping. This poster explains with analytic theory and simulations the new algebraic damping due to both mobility and diffusive fluxes. As electrons are swept around the ``cat's eye'' orbits of resonant wave-particle interaction, they form a dipole (m = 1) density distribution, and the electric field from this distribution produces an E × B drift of the core back to the axis, i.e. damps the m = 1 mode. Supported by National Science Foundation Grant PHY-1414570.

Evidence for the frequency-shift of the OA A_1g mode in Hg-based superconductors

NASA Astrophysics Data System (ADS)

Yang, In-Sang; Lee, Hye-Gyong

1996-03-01

The Hg-based superconductors, HgBa_2Ca_n-1Cu_nO_2n+2+δ (n=1,2,3) have two strong Raman peaks at ~ 570 and 590 cm-1 in the high-frequency region. From the results of Raman measurements of Tl-doped Hg-1223 system, it is concluded that the peak at ~ 570 cm-1 does not arise from the vibration of the interstitial oxygen O_δ in the Hg/Tl-O plane, but from the frequency-shift of the A_1g-type vibration of the apical oxygen O_A. The peak at 570 cm-1 is from the O_As surrounded by the O_δs in the nearest neighbor, while the 590 cm-1 mode is from the O_As without the O_δs in the immediate neighbor. The intensity of the 570 cm-1 mode increases with the O_δ content, but the Raman frequencies of both modes do not change significantly. This suggests that the increase of the frequency of the OA A_1g mode under high pressure (I.-S. Yang et al., Phys. Rev. B 51, 644 (1995)) is independent from the O_δ content, in the Hg-based superconductors.

Vibrational mode frequencies of H2S and H2O adsorbed on Ge(0 0 1)-(2 × 1) surfaces

NASA Astrophysics Data System (ADS)

Hartnett, M.; Fahy, S.

2015-02-01

The equilibrium geometry and vibrational modes of H2S and H2O-terminated Ge(0 0 1)-(2 × 1) surfaces are calculated in a supercell approach using first-principles density functional theory in the local density (LDA), generalized gradient (GGA) approximations and van der Waals (vdW) interactions. Mode frequencies are found using the frozen phonon method. For the H2S-passivated surface, the calculated frequencies in LDA (GGA) are 2429 cm-1 (2490) for the Hsbnd S stretch mode, 712 cm-1 (706) for the Hsbnd S bond bending mode, 377 cm-1 (36) for the Gesbnd S stretch mode and 328 cm-1 (337) for Hsbnd S wag mode. Frequencies for the H2O passivated surface are 3590 cm-1 (3600) for the Hsbnd O stretch mode, 921 cm-1 (947) for the bending mode, 609 cm-1 (559) for the Gesbnd O stretch, 1995 cm-1 (1991) for the Gesbnd H stretch mode, 498 cm-1 (478) for the Gesbnd H bending mode and 342 cm-1 (336) for the Hsbnd O wag mode. The differences between the functionals including vdW terms and the LDA or GGA are less than the differences between LDA and GGA for the vibrational mode frequencies.

Mod 1 wind turbine generator failure modes and effects analysis

NASA Technical Reports Server (NTRS)

1979-01-01

A failure modes and effects analysis (FMEA) was directed primarily at identifying those critical failure modes that would be hazardous to life or would result in major damage to the system. Each subsystem was approached from the top down, and broken down to successive lower levels where it appeared that the criticality of the failure mode warranted more detail analysis. The results were reviewed by specialists from outside the Mod 1 program, and corrective action taken wherever recommended.

Contrast Invariant Interest Point Detection by Zero-Norm LoG Filter.

PubMed

Zhenwei Miao; Xudong Jiang; Kim-Hui Yap

2016-01-01

The Laplacian of Gaussian (LoG) filter is widely used in interest point detection. However, low-contrast image structures, though stable and significant, are often submerged by the high-contrast ones in the response image of the LoG filter, and hence are difficult to be detected. To solve this problem, we derive a generalized LoG filter, and propose a zero-norm LoG filter. The response of the zero-norm LoG filter is proportional to the weighted number of bright/dark pixels in a local region, which makes this filter be invariant to the image contrast. Based on the zero-norm LoG filter, we develop an interest point detector to extract local structures from images. Compared with the contrast dependent detectors, such as the popular scale invariant feature transform detector, the proposed detector is robust to illumination changes and abrupt variations of images. Experiments on benchmark databases demonstrate the superior performance of the proposed zero-norm LoG detector in terms of the repeatability and matching score of the detected points as well as the image recognition rate under different conditions.

77 FR 2715 - D'Lo Gas Storage, LLC; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-19

... Storage, LLC; Notice of Application Take notice that on December 29, 2011, D'Lo Gas Storage, LLC (D'Lo... natural gas storage project to be located in Simpson County, Mississippi. Additionally, D'Lo requests a...- discriminatory firm interruptible natural gas storage services and hub services, and a blanket certificate...

Multiphoton endoscopy based on a mode-filtered single-mode fiber

NASA Astrophysics Data System (ADS)

Moon, Sucbei; Liu, Gangjun; Chen, Zhongping

2011-03-01

We present a new low-nonlinearity fiber of mode-filtered large-core fiber for flexible beam delivery of intense pulsed light aiming at multi-photon endoscopy application. A multimode fiber of a large core diameter (20 μm) equips a mode filtering means in the middle of the fiber link to suppress the high-order modes selectively. A large effective core area of ~200 μm2 has been achieved at 0.8-μm and 1.0-μm bands. This is 8 times larger than the core area of a conventional SMF used for those spectral bands. Various advantages of our large-mode area fiber will be demonstrated and discussed in this report.

XYZ-like spectra from Laplace sum rule at N2LO in the chiral limit

NASA Astrophysics Data System (ADS)

Albuquerque, R.; Narison, S.; Fanomezana, F.; Rabemananjara, A.; Rabetiarivony, D.; Randriamanatrika, G.

2016-12-01

We present new compact integrated expressions of QCD spectral functions of heavy-light molecules and four-quark XY Z-like states at lowest order (LO) of perturbative (PT) QCD and up to d = 8 condensates of the Operator Product Expansion (OPE). Then, by including up to next-to-next leading order (N2LO) PT QCD corrections, which we have estimated by assuming the factorization of the four-quark spectral functions, we improve previous LO results from QCD spectral sum rules (QSSR), on the XY Z-like masses and decay constants which suffer from the ill-defined heavy quark mass. PT N3LO corrections are estimated using a geometric growth of the PT series and are included in the systematic errors. Our optimal results based on stability criteria are summarized in Tables 11-14 and compared, in Sec. 10, with experimental candidates and some LO QSSR results. We conclude that the masses of the XZ observed states are compatible with (almost) pure JPC = 1+±, 0++ molecule or/and four-quark states. The ones of the 1-±, 0-± molecule/four-quark states are about 1.5 GeV above the Yc,b mesons experimental candidates and hadronic thresholds. We also find that the couplings of these exotics to the associated interpolating currents are weaker than that of ordinary D,B mesons (fDD ≈ 10-3f D) and may behave numerically as 1/m¯b3/2 (respectively 1/m¯b) for the 1+, 0+ (respectively 1-, 0-) states which can stimulate further theoretical studies of these decay constants.

LoCoH: Non-parameteric kernel methods for constructing home ranges and utilization distributions

USGS Publications Warehouse

Getz, Wayne M.; Fortmann-Roe, Scott; Cross, Paul C.; Lyons, Andrew J.; Ryan, Sadie J.; Wilmers, Christopher C.

2007-01-01

Parametric kernel methods currently dominate the literature regarding the construction of animal home ranges (HRs) and utilization distributions (UDs). These methods frequently fail to capture the kinds of hard boundaries common to many natural systems. Recently a local convex hull (LoCoH) nonparametric kernel method, which generalizes the minimum convex polygon (MCP) method, was shown to be more appropriate than parametric kernel methods for constructing HRs and UDs, because of its ability to identify hard boundaries (e.g., rivers, cliff edges) and convergence to the true distribution as sample size increases. Here we extend the LoCoH in two ways: ‘‘fixed sphere-of-influence,’’ or r -LoCoH (kernels constructed from all points within a fixed radius r of each reference point), and an ‘‘adaptive sphere-of-influence,’’ or a -LoCoH (kernels constructed from all points within a radius a such that the distances of all points within the radius to the reference point sum to a value less than or equal to a ), and compare them to the original ‘‘fixed-number-of-points,’’ or k -LoCoH (all kernels constructed from k -1 nearest neighbors of root points). We also compare these nonparametric LoCoH to parametric kernel methods using manufactured data and data collected from GPS collars on African buffalo in the Kruger National Park, South Africa. Our results demonstrate that LoCoH methods are superior to parametric kernel methods in estimating areas used by animals, excluding unused areas (holes) and, generally, in constructing UDs and HRs arising from the movement of animals influenced by hard boundaries and irregular structures (e.g., rocky outcrops). We also demonstrate that a -LoCoH is generally superior to k - and r -LoCoH (with software for all three methods available at http://locoh.cnr.berkeley.edu).

Forwarding techniques for IP fragmented packets in a real 6LoWPAN network.

PubMed

Ludovici, Alessandro; Calveras, Anna; Casademont, Jordi

2011-01-01

Wireless Sensor Networks (WSNs) are attracting more and more interest since they offer a low-cost solution to the problem of providing a means to deploy large sensor networks in a number of application domains. We believe that a crucial aspect to facilitate WSN diffusion is to make them interoperable with external IP networks. This can be achieved by using the 6LoWPAN protocol stack. 6LoWPAN enables the transmission of IPv6 packets over WSNs based on the IEEE 802.15.4 standard. IPv6 packet size is considerably larger than that of IEEE 802.15.4 data frame. To overcome this problem, 6LoWPAN introduces an adaptation layer between the network and data link layers, allowing IPv6 packets to be adapted to the lower layer constraints. This adaptation layer provides fragmentation and header compression of IP packets. Furthermore, it also can be involved in routing decisions. Depending on which layer is responsible for routing decisions, 6LoWPAN divides routing in two categories: mesh under if the layer concerned is the adaptation layer and route over if it is the network layer. In this paper we analyze different routing solutions (route over, mesh under and enhanced route over) focusing on how they forward fragments. We evaluate their performance in terms of latency and energy consumption when transmitting IP fragmented packets. All the tests have been performed in a real 6LoWPAN implementation. After consideration of the main problems in forwarding of mesh frames in WSN, we propose and analyze a new alternative scheme based on mesh under, which we call controlled mesh under.

Forwarding Techniques for IP Fragmented Packets in a Real 6LoWPAN Network

PubMed Central

Ludovici, Alessandro; Calveras, Anna; Casademont, Jordi

2011-01-01

Wireless Sensor Networks (WSNs) are attracting more and more interest since they offer a low-cost solution to the problem of providing a means to deploy large sensor networks in a number of application domains. We believe that a crucial aspect to facilitate WSN diffusion is to make them interoperable with external IP networks. This can be achieved by using the 6LoWPAN protocol stack. 6LoWPAN enables the transmission of IPv6 packets over WSNs based on the IEEE 802.15.4 standard. IPv6 packet size is considerably larger than that of IEEE 802.15.4 data frame. To overcome this problem, 6LoWPAN introduces an adaptation layer between the network and data link layers, allowing IPv6 packets to be adapted to the lower layer constraints. This adaptation layer provides fragmentation and header compression of IP packets. Furthermore, it also can be involved in routing decisions. Depending on which layer is responsible for routing decisions, 6LoWPAN divides routing in two categories: mesh under if the layer concerned is the adaptation layer and route over if it is the network layer. In this paper we analyze different routing solutions (route over, mesh under and enhanced route over) focusing on how they forward fragments. We evaluate their performance in terms of latency and energy consumption when transmitting IP fragmented packets. All the tests have been performed in a real 6LoWPAN implementation. After consideration of the main problems in forwarding of mesh frames in WSN, we propose and analyze a new alternative scheme based on mesh under, which we call controlled mesh under. PMID:22346615

Two-mode PLC-based mode multi/demultiplexer for mode and wavelength division multiplexed transmission.

PubMed

Hanzawa, Nobutomo; Saitoh, Kuimasa; Sakamoto, Taiji; Matsui, Takashi; Tsujikawa, Kyozo; Koshiba, Masanori; Yamamoto, Fumihiko

2013-11-04

We proposed a PLC-based mode multi/demultiplexer (MUX/DEMUX) with an asymmetric parallel waveguide for mode division multiplexed (MDM) transmission. The mode MUX/DEMUX including a mode conversion function with an asymmetric parallel waveguide can be realized by matching the effective indices of the LP(01) and LP(11) modes of two waveguides. We report the design of a mode MUX/DEMUX that can support C-band WDM-MDM transmission. The fabricated mode MUX/DEMUX realized a low insertion loss of less than 1.3 dB and high a mode extinction ratio that exceeded 15 dB. We used the fabricated mode MUX/DEMUX to achieve a successful 2 mode x 4 wavelength x 10 Gbps transmission over a 9 km two-mode fiber with a penalty of less than 1 dB.

The origins of metamodality in visual object area LO: Bodily topographical biases and increased functional connectivity to S1

PubMed Central

Tal, Zohar; Geva, Ran; Amedi, Amir

2016-01-01

Recent evidence from blind participants suggests that visual areas are task-oriented and sensory modality input independent rather than sensory-specific to vision. Specifically, visual areas are thought to retain their functional selectivity when using non-visual inputs (touch or sound) even without having any visual experience. However, this theory is still controversial since it is not clear whether this also characterizes the sighted brain, and whether the reported results in the sighted reflect basic fundamental a-modal processes or are an epiphenomenon to a large extent. In the current study, we addressed these questions using a series of fMRI experiments aimed to explore visual cortex responses to passive touch on various body parts and the coupling between the parietal and visual cortices as manifested by functional connectivity. We show that passive touch robustly activated the object selective parts of the lateral–occipital (LO) cortex while deactivating almost all other occipital–retinotopic-areas. Furthermore, passive touch responses in the visual cortex were specific to hand and upper trunk stimulations. Psychophysiological interaction (PPI) analysis suggests that LO is functionally connected to the hand area in the primary somatosensory homunculus (S1), during hand and shoulder stimulations but not to any of the other body parts. We suggest that LO is a fundamental hub that serves as a node between visual-object selective areas and S1 hand representation, probably due to the critical evolutionary role of touch in object recognition and manipulation. These results might also point to a more general principle suggesting that recruitment or deactivation of the visual cortex by other sensory input depends on the ecological relevance of the information conveyed by this input to the task/computations carried out by each area or network. This is likely to rely on the unique and differential pattern of connectivity for each visual area with the rest of the

The CEA-/lo colorectal cancer cell population harbors cancer stem cells and metastatic cells.

PubMed

Yan, Chang; Hu, Yibing; Zhang, Bo; Mu, Lei; Huang, Kaiyu; Zhao, Hui; Ma, Chensen; Li, Xiaolan; Tao, Deding; Gong, Jianping; Qin, Jichao

2016-12-06

Serum carcinoembryonic antigen (CEA) is the most commonly used tumor marker in a variety of cancers including colorectal cancer (CRC) for tumor diagnosis and monitoring. Recent studies have shown that colonic crypt cells expressing little or no CEA may enrich for stem cells. Numerous studies have clearly shown that there exist CRC patients with normal serum CEA levels during tumor progression or even tumor relapse, although CEA itself is considered to promote metastasis and block cell differentiation. These seemingly contradictory observations prompted us to investigate, herein, the biological properties as well as tumorigenic and metastatic capacity of CRC cells that express high (CEA+) versus low CEA (CEA-/lo) levels of CEA. Our findings show that the abundance of CEA-/lo cells correlate with poor differentiation and poor prognosis, and moreover, CEA-/lo cells form more spheres in vitro, generate more tumors and exhibit a higher potential in developing liver and lung metastases than corresponding CEA+ cells. Applying RNAi-mediated approach, we found that IGF1R mediated tumorigenic and capacity of CEA-/lo cells but did not mediate those of CEA+ cells. Notably, our data demonstrated that CEA molecule was capable of protecting CEA-/lo cells from anoikis, implying that CEA+ cells, although themselves possessing less tumorigenic and metastatic capacity, may promote metastasis of CEA-/lo cells via secreting CEA molecule. Our observations suggest that, besides targeting CEA molecule, CEA-/lo cells may represent a critical source of tumor progression and metastasis, and should therefore be the target of future therapies.

"Good Vibrations": A workshop on oscillations and normal modes

NASA Astrophysics Data System (ADS)

Barbieri, Sara; Carpineti, Marina; Giliberti, Marco; Rigon, Enrico; Stellato, Marco; Tamborini, Marina

2016-05-01

We describe some theatrical strategies adopted in a two hour workshop in order to show some meaningful experiments and the underlying useful ideas to describe a secondary school path on oscillations, that develops from harmonic motion to normal modes of oscillations, and makes extensive use of video analysis, data logging, slow motions and applet simulations. Theatre is an extremely useful tool to stimulate motivation starting from positive emotions. That is the reason why the theatrical approach to the presentation of physical themes has been explored by the group "Lo spettacolo della Fisica" (http://spettacolo.fisica.unimi.it) of the Physics Department of University of Milano for the last ten years (Carpineti et al., JCOM, 10 (2011) 1; Nuovo Cimento B, 121 (2006) 901) and has been inserted also in the European FP7 Project TEMI (Teaching Enquiry with Mysteries Incorporated, see http://teachingmysteries.eu/en) which involves 13 different partners coming from 11 European countries, among which the Italian (Milan) group. According to the TEMI guidelines, this workshop has a written script based on emotionally engaging activities of presenting mysteries to be solved while participants have been involved in nice experiments following the developed path.

Effect of Propellant Flowrate and Purity on Carbon Deposition in LO2/Methane Gas Generators

NASA Technical Reports Server (NTRS)

Bossard, J. A.; Burkhardt, W. M.; Niiya, K. Y.; Braam, F.

1989-01-01

The generation and deposition of carbon was studied in the Carbon Deposition Program using subscale hardware with LO2/Liquid Natural Gas (LNG) and LO2/Methane propellants at low mixture ratios. The purpose of the testing was to evaluate the effect of methane purity and full scale injection density on carbon deposition. The LO2/LNG gas generator/preburner testing was performed at mixture ratios between 0.24 and 0.58 and chamber pressures from 5.8 to 9.4 MPa (840 to 1370 psia). A total of seven 200 second duration tests were performed. The LNG testing occurred at low injection densities, similar to the previous LO2/RP-1, LO2/propane, and LO2/methane testing performed on the carbon deposition program. The current LO2/methane test series occurred at an injection density factor of approximately 10 times higher than the previous testing. The high injection density LO2/methane testing was performed at mixture ratios between from 0.23 to 0.81 and chamber pressures from 6.4 to 15.2 MPa (925 to 2210 psia). A total of nine high injection density tests were performed. The testing performed demonstrated that low purity methane (LNG) did not produce any detectable change in carbon deposition when compared to pure methane. In addition, the C* performance and the combustion gas temperatures measured were similar to those obtained for pure methane. Similar results were obtained testing pure methane at higher propellant injection densities with coarse injector elements.

[Effects of different hypoxic training modes on activities of mitochondrial antioxidants and respiratory chain complex in skeletal muscle after exhaustive running in rat].

PubMed

Li, Jie; Zhang, Yao-Bin

2011-02-25

The present study was aimed to investigate the effect of hypoxic training on mitochondrial antioxidants and activities of respiratory chain complexes in mitochondria of skeletal muscle in rats. Forty healthy male Wistar rats were randomized to 5 groups (n=8): living low-training low (LoLo), living high-training high (HiHi), living high-training low (HiLo), living low-training high (LoHi), and living high-exercise high-training low (HiHiLo). All the animals were subjected to 5-week training in normoxic (atmospheric pressure=632 mmHg, altitude of about 1 500 m) or hypoxic environment (atmospheric pressure=493 mmHg, simulated altitude of about 3 500 m). Before exhaustive running, the animals stayed in normoxia for 3 d. Skeletal muscles were prepared immediately after exhaustive running. Muscle mitochondria were extracted by differential centrifugation. Spectrophotometric analysis was used to evaluate activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), malondialdehyde (MDA) level and respiratory chain complex (C) I-III activities in muscle homogenate and mitochondria. Results showed that SOD, GSH-Px, CAT activities and MDA level in skeletal muscle homogenate in HiHi and HiHiLo groups were significantly increased (P<0.05 or P<0.01) compared with those in LoLo group. Muscle mitochondrial MDA level in HiHi and HiHiLo groups was significantly lower (P<0.01), while activities of SOD, GSH-Px and CAT were remarkably higher (P<0.01) than those in LoLo group. Meanwhile, C I-III activities in HiHi and HiHiLo groups were increased significantly (P<0.01), and C II activity in HiLo group also was increased remarkably (P<0.01) compared with those in LoLo group. These results suggest that HiHiLo might be an ideal hypoxic training mode.

m=1 diocotron mode damping in the Electron Diffusion Gauge (EDG) experiment

NASA Astrophysics Data System (ADS)

Paul, Stephen F.; Morrison, Kyle A.; Davidson, Ronald C.; Jenkins, Thomas G.

2002-01-01

The evolution of the amplitude of the m=1 diocotron mode is used to measure the background neutral pressure in the Electron Diffusion Gauge (EDG), a Malmberg-Penning trap. Below 5×10-8 Torr, the dependence on pressure scales as P1/4, and is sensitive to pressure changes as small as ΔP=5×10-11 Torr. Previous studies on the EDG showed that the diocotron mode is more strongly damped at higher neutral pressures. Both the diocotron mode damping rate and the plasma expansion rate depend similarly on experimental parameters, i.e., conditions which favor expansion also favor suppression of the diocotron mode. The sensitivity of the mode evolution is examined as a function of the resistive growth driving conditions, which are controlled by the amount of wall resistance connected to the trap.

The Global Mode-1 S2 Internal Tide

NASA Astrophysics Data System (ADS)

Zhao, Zhongxiang

2017-11-01

The global mode-1 S2 internal tide is observed using sea surface height (SSH) measurements from four satellite altimeters: TOPEX/Poseidon, Jason-1, Jason-2, and Geosat Follow-On. Plane wave analysis is employed to extract three mode-1 S2 internal tidal waves in any given 250 km by 250 km window, which are temporally coherent over a 20 year period from 1992 to 2012. Depth-integrated energy and flux of the S2 internal tide are calculated from the SSH amplitude and a conversion function built from climatological hydrographic profiles in the World Ocean Atlas 2013. The results show that the S2 and M2 internal tides have similar spatial patterns. Both S2 and M2 internal tides originate at major topographic features and propagate over long distances. The S2 internal tidal beams are generally shorter, likely because the relatively weaker S2 internal tide is easily overwhelmed by nontidal noise. The northbound S2 and M2 internal tides from the Hawaiian Ridge are observed to travel over 3500 km across the Northeast Pacific. The globally integrated energy of the mode-1 S2 internal tide is 7.8 PJ (1 PJ = 1015 J), about 20% that of M2 (36.4 PJ). The histogram of S2 to M2 SSH ratios peaks at 0.4, consistent with the square root of their energy ratio. In terms of SSH, S2 is greater than M2 in ≈10% of the global ocean and ≥50% of M2 in about half of the global ocean.

A Study of LoRa: Long Range & Low Power Networks for the Internet of Things.

PubMed

Augustin, Aloÿs; Yi, Jiazi; Clausen, Thomas; Townsley, William Mark

2016-09-09

LoRa is a long-range, low-power, low-bitrate, wireless telecommunications system, promoted as an infrastructure solution for the Internet of Things: end-devices use LoRa across a single wireless hop to communicate to gateway(s), connected to the Internet and which act as transparent bridges and relay messages between these end-devices and a central network server. This paper provides an overview of LoRa and an in-depth analysis of its functional components. The physical and data link layer performance is evaluated by field tests and simulations. Based on the analysis and evaluations, some possible solutions for performance enhancements are proposed.

A Study of LoRa: Long Range & Low Power Networks for the Internet of Things

PubMed Central

Augustin, Aloÿs; Yi, Jiazi; Clausen, Thomas; Townsley, William Mark

2016-01-01

LoRa is a long-range, low-power, low-bitrate, wireless telecommunications system, promoted as an infrastructure solution for the Internet of Things: end-devices use LoRa across a single wireless hop to communicate to gateway(s), connected to the Internet and which act as transparent bridges and relay messages between these end-devices and a central network server. This paper provides an overview of LoRa and an in-depth analysis of its functional components. The physical and data link layer performance is evaluated by field tests and simulations. Based on the analysis and evaluations, some possible solutions for performance enhancements are proposed. PMID:27618064

Development of HiLo Microscope and its use in In-Vivo Applications

NASA Astrophysics Data System (ADS)

Patel, Shreyas J.

The functionality of achieving optical sectioning in biomedical research is invaluable as it allows for visualization of a biological sample at different depths while being free of background scattering. Most current microscopy techniques that offer optical sectioning, unfortunately, require complex instrumentation and thus are generally costly. HiLo microscopy, on the other hand, offers the same functionality and advantage at a relatively low cost. Hence, the work described in this thesis involves the design, build, and application of a HiLo microscope. More specifically, a standalone HiLo microscope was built in addition to implementing HiLo microscopy on a standard fluorescence microscope. In HiLo microscopy, optical sectioning is achieved by acquiring two different types of images per focal plane. One image is acquired under uniform illumination and the other is acquired under speckle illumination. These images are processed using an algorithm that extracts in-focus information and removes features and glare that occur as a result of background fluorescence. To show the benefits of the HiLo microscopy, several imaging experiments on various samples were performed under a HiLo microscope and compared against a traditional fluorescence microscope and a confocal microscope, which is considered the gold standard in optical imaging. In-vitro and ex-vivo imaging was performed on a set of pollen grains, and optically cleared mouse brain and heart slices. Each of these experiments showed great reduction in background scattering at different depths under HiLo microscopy. More importantly, HiLo imaging of optically cleared heart slice demonstrated emergence of different vasculature at different depths. Reduction of out-of-focus light increased the spatial resolution and allowed better visualization of capillary vessels. Furthermore, HiLo imaging was tested in an in-vivo model of a rodent dorsal window chamber model. When imaging the same sample under confocal microscope

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kerimova, T. G., E-mail: taira-kerimova@mail.ru; Abdullaev, N. A.; Mamedova, I. A.

The Raman spectra of CdGa{sub 2}S{sub 4x}Se{sub 4(1-x)} alloys (x = 0.1, 0.2, Horizontal-Ellipsis 0.9) are studied. Both the singlemode and double-mode behavior of optical phonons are observed in CdGa{sub 2}S{sub 4x}Se{sub 4(1-x)} alloys. The observed optical mode at 138 cm{sup -1} is independent of the composition. It seems likely that this mode is the 'breathing mode' and is caused by atomic motion in the anion sublattice relative to vacancies. It is shown that the high-frequency modes of symmetry B{sub 1}(LO, TO) and B{sub 2}(LO, TO) are caused by the in-phase motion of atoms in the anion sublattice along themore » tetragonal axis c relative to trivalent Ga atoms. The doubly degenerate symmetry modes E{sub 1}(LO, TO) and E{sub 2}(LO, TO) are caused by the in-phase motion of atoms in the anion sublattice relative to trivalent Ga atoms of the cation sublattice in the xy plane (dipole 2Ga-4C), where C is S, Se. The optical symmetry modes B{sub 3}(LO, TO) and B{sub 4}(LO, TO) are associated with the motion of atoms in the anion sublattice relative to Cd atoms along the tetragonal axis c. The doubly degenerate modes E{sub 3}(LO, TO) and E{sub 4}(LO, TO) are associated with the motion of atoms in the anion sublattice relative to Cd atoms (dipole Cd-4C). The low-frequency modes B{sub 5}(LO, TO) and E{sub 5}(LO, TO) are the analogs of acoustic phonons at the edge of the Brillouin zone of sphalerite.« less

Sedimentation survey of Lago Loíza, Trujillo Alto, Puerto Rico, July 2009

USGS Publications Warehouse

Soler-López, Luis R.; Licha-Soler, N.A.

2014-01-01

Lago Loíza is a reservoir formed at the confluence of Río Gurabo and Río Grande de Loíza in the municipality of Trujillo Alto in central Puerto Rico, about 10 kilometers (km) north of the town of Caguas, about 9 km northwest of Gurabo, and about 3 km south of Trujillo Alto (fig. 1). The Carraizo Dam is owned and operated by the Puerto Rico Aqueduct and Sewer Authority (PRASA), and was constructed in 1953 as a water-supply reservoir for the San Juan Metropolitan area. The dam is a concrete gravity structure that is located in a shallow valley and has a gently sloping left abutment and steep right abutment. Non-overflow sections flank the spillway section. Waterways include an intake structure for the pumping station and power plant, sluiceways, a trash sluice, and a spillway. The reservoir was built to provide a storage capacity of 26.8 million cubic meters (Mm3) of water at the maximum pool elevation of 41.14 meters (m) above mean sea level (msl) for the Sergio Cuevas Filtration Plant that serves the San Juan metropolitan area. The reservoir has a drainage area of 538 square kilometers (km2) and receives an annual mean rainfall that ranges from 1,600 to 5,000 millimeters per year (mm/yr). The principal streams that drain into Lago Loíza are the Río Grande de Loíza, Río Gurabo, and Río Cañas. Two other rivers, the Río Bairoa and Río Cagüitas, discharge into the Río Grande de Loíza just before it enters the reservoir. The combined mean annual runoff of the Río Grande de Loíza and the Río Gurabo for the 1960–2009 period of record is 323 Mm3. Flow from these streams constitutes about 89 percent of the total mean annual inflow of 364 Mm3 to the reservoir (U.S. Geological Survey, 2009). Detailed information about Lago Loíza reservoir structures, historical sediment accumulation, and a dredge conducted in 1999 are available in Soler-López and Gómez-Gómez (2005). During July 8–15, 2009, the U.S. Geological Survey (USGS) Caribbean Water Science

A Theoretical and Experimental Comparison of 3-3 and 3-1 Mode Piezoelectric Microelectromechanical Systems (MEMS)

PubMed Central

Kim, Donghwan; Hewa-Kasakarage, Nishshanka; Hall, Neal A.

2014-01-01

Two piezoelectric transducer modes applied in microelectromechanical systems are (i) the 3-1 mode with parallel electrodes perpendicular to a vertical polarization vector, and (ii) the 3-3 mode which uses interdigitated (IDT) electrodes to realize an in-plane polarization vector. This study compares the two configurations by deriving a Norton equivalent representation of each approach – including expressions for output charge and device capacitance. The model is verified using a microfabricated device comprised of multiple epitaxial silicon beams with sol-gel deposited lead zirconate titanate at the surface. The beams have identical dimensions and are attached to a common moving element at their tip. The only difference between beams is electrode configuration – enabling a direct comparison. Capacitance and charge measurements verify the presented theory with high accuracy. The Norton equivalent representation is general and enables comparison of any figure of merit, including electromechanical coupling coefficient and signal to noise ratio. With respect to coupling coefficient, the experimentally validated theory in this work suggests that 3-3 mode IDT-electrode configurations offer the potential for modest improvements compared against 3-1 mode devices (less than 2×), and the only geometrical parameter affecting this ratio is the fill factor of the IDT electrode. PMID:25309041

Rocket-Based Combined Cycle Flowpath Testing for Modes 1 and 4

NASA Technical Reports Server (NTRS)

Rice, Tharen

2002-01-01

Under sponsorship of the NASA Glenn Research Center (NASA GRC), the Johns Hopkins University Applied Physics Laboratory (JHU/APL) designed and built a five-inch diameter, Rocket-Based Combined Cycle (RBCC) engine to investigate mode 1 and mode 4 engine performance as well as Mach 4 inlet performance. This engine was designed so that engine area and length ratios were similar to the NASA GRC GTX engine is shown. Unlike the GTX semi-circular engine design, the APL engine is completely axisymmetric. For this design, a traditional rocket thruster was installed inside of the scramjet flowpath, along the engine centerline. A three part test series was conducted to determine Mode I and Mode 4 engine performance. In part one, testing of the rocket thruster alone was accomplished and its performance determined (average Isp efficiency = 90%). In part two, Mode 1 (air-augmented rocket) testing was conducted at a nominal chamber pressure-to-ambient pressure ratio of 100 with the engine inlet fully open. Results showed that there was neither a thrust increment nor decrement over rocket-only thrust during Mode 1 operation. In part three, Mode 4 testing was conducted with chamber pressure-to-ambient pressure ratios lower than desired (80 instead of 600) with the inlet fully closed. Results for this testing showed a performance decrease of 20% as compared to the rocket-only testing. It is felt that these results are directly related to the low pressure ratio tested and not the engine design. During this program, Mach 4 inlet testing was also conducted. For these tests, a moveable centerbody was tested to determine the maximum contraction ratio for the engine design. The experimental results agreed with CFD results conducted by NASA GRC, showing a maximum geometric contraction ratio of approximately 10.5. This report details the hardware design, test setup, experimental results and data analysis associated with the aforementioned tests.

Raman scattering studies of strain effects in (100) and (311)B GaAs1-xBix epitaxial layers

NASA Astrophysics Data System (ADS)

Steele, J. A.; Lewis, R. A.; Henini, M.; Lemine, O. M.; Alkaoud, A.

2013-11-01

We report room-temperature Raman studies of strained (100) and (311)B GaAs1-xBix epitaxial layers for x ≤ 0.039. The Raman spectra exhibit a two-mode behavior, as well as disorder-activated GaAs-like phonons. The experimental results show that the GaAs-like LO(Γ) mode experiences a strong composition-dependent redshift as a result of alloying. The peak frequency decreases linearly from the value for pure GaAs (˜293 cm-1) with the alloyed Bi fraction x and the introduced in-plane lattice strain ɛ∥, by ΔωLO=Δωalloy-Δωstrain. X-ray diffraction measurements are used to determine x and ɛ∥ allowing Δωalloy to be decoupled and is estimated to be -12(±4) cm-1/x for (100) GaAs1-xBix. ΔωLO is measured to be roughly double for samples grown on (311)B-oriented substrates to that of (100) GaAs. This large difference in redshift is accounted for by examining the Bi induced strain, effects from alloying, and defects formed during high-index (311)B crystal growth.

Optically sectioned in vivo imaging with speckle illumination HiLo microscopy

PubMed Central

Lim, Daryl; Ford, Tim N.; Chu, Kengyeh K.; Mertz, Jerome

2011-01-01

We present a simple wide-field imaging technique, called HiLo microscopy, that is capable of producing optically sectioned images in real time, comparable in quality to confocal laser scanning microscopy. The technique is based on the fusion of two raw images, one acquired with speckle illumination and another with standard uniform illumination. The fusion can be numerically adjusted, using a single parameter, to produce optically sectioned images of varying thicknesses with the same raw data. Direct comparison between our HiLo microscope and a commercial confocal laser scanning microscope is made on the basis of sectioning strength and imaging performance. Specifically, we show that HiLo and confocal 3-D imaging of a GFP-labeled mouse brain hippocampus are comparable in quality. Moreover, HiLo microscopy is capable of faster, near video rate imaging over larger fields of view than attainable with standard confocal microscopes. The goal of this paper is to advertise the simplicity, robustness, and versatility of HiLo microscopy, which we highlight with in vivo imaging of common model organisms including planaria, C. elegans, and zebrafish. PMID:21280920

Optically sectioned in vivo imaging with speckle illumination HiLo microscopy.

PubMed

Lim, Daryl; Ford, Tim N; Chu, Kengyeh K; Mertz, Jerome

2011-01-01

We present a simple wide-field imaging technique, called HiLo microscopy, that is capable of producing optically sectioned images in real time, comparable in quality to confocal laser scanning microscopy. The technique is based on the fusion of two raw images, one acquired with speckle illumination and another with standard uniform illumination. The fusion can be numerically adjusted, using a single parameter, to produce optically sectioned images of varying thicknesses with the same raw data. Direct comparison between our HiLo microscope and a commercial confocal laser scanning microscope is made on the basis of sectioning strength and imaging performance. Specifically, we show that HiLo and confocal 3-D imaging of a GFP-labeled mouse brain hippocampus are comparable in quality. Moreover, HiLo microscopy is capable of faster, near video rate imaging over larger fields of view than attainable with standard confocal microscopes. The goal of this paper is to advertise the simplicity, robustness, and versatility of HiLo microscopy, which we highlight with in vivo imaging of common model organisms including planaria, C. elegans, and zebrafish.

Optically sectioned in vivo imaging with speckle illumination HiLo microscopy

NASA Astrophysics Data System (ADS)

Lim, Daryl; Ford, Tim N.; Chu, Kengyeh K.; Mertz, Jerome

2011-01-01

We present a simple wide-field imaging technique, called HiLo microscopy, that is capable of producing optically sectioned images in real time, comparable in quality to confocal laser scanning microscopy. The technique is based on the fusion of two raw images, one acquired with speckle illumination and another with standard uniform illumination. The fusion can be numerically adjusted, using a single parameter, to produce optically sectioned images of varying thicknesses with the same raw data. Direct comparison between our HiLo microscope and a commercial confocal laser scanning microscope is made on the basis of sectioning strength and imaging performance. Specifically, we show that HiLo and confocal 3-D imaging of a GFP-labeled mouse brain hippocampus are comparable in quality. Moreover, HiLo microscopy is capable of faster, near video rate imaging over larger fields of view than attainable with standard confocal microscopes. The goal of this paper is to advertise the simplicity, robustness, and versatility of HiLo microscopy, which we highlight with in vivo imaging of common model organisms including planaria, C. elegans, and zebrafish.

High-contrast 3D image acquisition using HiLo microscopy with an electrically tunable lens

NASA Astrophysics Data System (ADS)

Philipp, Katrin; Smolarski, André; Fischer, Andreas; Koukourakis, Nektarios; Stürmer, Moritz; Wallrabe, Ulricke; Czarske, Jürgen

2016-04-01

We present a HiLo microscope with an electrically tunable lens for high-contrast three-dimensional image acquisition. HiLo microscopy combines wide field and speckled illumination images to create optically sectioned images. Additionally, the depth-of-field is not fixed, but can be adjusted between wide field and confocal-like axial resolution. We incorporate an electrically tunable lens in the HiLo microscope for axial scanning, to obtain three-dimensional data without the need of moving neither the sample nor the objective. The used adaptive lens consists of a transparent polydimethylsiloxane (PDMS) membrane into which an annular piezo bending actuator is embedded. A transparent fluid is filled between the membrane and the glass substrate. When actuated, the piezo generates a pressure in the lens which deflects the membrane and thus changes the refractive power. This technique enables a large tuning range of the refractive power between 1/f = (-24 . . . 25) 1/m. As the NA of the adaptive lens is only about 0.05, a fixed high-NA lens is included in the setup to provide high resolution. In this contribution, the scan properties and capabilities of the tunable lens in the HiLo microscope are analyzed. Eventually, exemplary measurements are presented and discussed.

Optically Sectioned Imaging of Microvasculature of In-Vivo and Ex-Vivo Thick Tissue Models with Speckle-illumination HiLo Microscopy and HiLo Image Processing Implementation in MATLAB Architecture

NASA Astrophysics Data System (ADS)

Suen, Ricky Wai

The work described in this thesis covers the conversion of HiLo image processing into MATLAB architecture and the use of speckle-illumination HiLo microscopy for use of ex-vivo and in-vivo imaging of thick tissue models. HiLo microscopy is a wide-field fluorescence imaging technique and has been demonstrated to produce optically sectioned images comparable to confocal in thin samples. The imaging technique was developed by Jerome Mertz and the Boston University Biomicroscopy Lab and has been implemented in our lab as a stand-alone optical setup and a modification to a conventional fluorescence microscope. Speckle-illumination HiLo microscopy combines two images taken under speckle-illumination and standard uniform-illumination to generate an optically sectioned image that reject out-of-focus fluorescence. The evaluated speckle contrast in the images is used as a weighting function where elements that move out-of-focus have a speckle contrast that decays to zero. The experiments shown here demonstrate the capability of our HiLo microscopes to produce optically-sectioned images of the microvasculature of ex-vivo and in-vivo thick tissue models. The HiLo microscope were used to image the microvasculature of ex-vivo mouse heart sections prepared for optical histology and the microvasculature of in-vivo rodent dorsal window chamber models. Studies in label-free surface profiling with HiLo microscopy is also presented.

Liquid Oxygen (LO2) propellant conditioning concept testing

NASA Technical Reports Server (NTRS)

Perry, Gretchen L. E.; Orth, Michael S.; Mehta, Gopal K.

1993-01-01

Marshall Space Flight Center (MSFC) and industry contractors have undertaken activities to develop a simplified liquid oxygen (LO2) propellant conditioning concept for future expendable launch vehicles. The objective of these activities is to reduce operations costs and timelines and to improve safety of these vehicles. The approach followed has been to identify novel concepts through system level studies and demonstrate the feasibility of these concepts through small-scale and full-scale testing. Testing will also provide data for design guidelines and validation of analytical models. Four different concepts are being investigated: no-bleed, low-bleed, use of a recirculation line, and helium (He) bubbling. This investigation is being done under a Joint Institutional Research and Development (JIRAD) program currently in effect between MSFC and General Dynamics Space Systems (GDSS). A full-scale test article, which is a facsimile of a propellant feed duct with an attached section to simulate heat input from a LO2 turbopump, will be tested at the Cold Flow Facility at MSFC's West Test Area. Liquid nitrogen (LN2), which has similar properties to LO2, will be used in place of LO2 for safety and budget reasons. Work to date includes design and fabrication of the test article, design of the test facility and initial fabrication, development of a test matrix and test procedures, initial predictions of test output, and heat leak calibration and heat exchanger tests on the test article. The tests for all propellant conditioning concepts will be conducted in the summer of 1993, with the final report completed by October, 1993.

4 × 20 Gbit/s mode division multiplexing over free space using vector modes and a q-plate mode (de)multiplexer

NASA Astrophysics Data System (ADS)

Milione, Giovanni; Lavery, Martin P. J.; Huang, Hao; Ren, Yongxiong; Xie, Guodong; Nguyen, Thien An; Karimi, Ebrahim; Marrucci, Lorenzo; Nolan, Daniel A.; Alfano, Robert R.; Willner, Alan E.

2015-05-01

Vector modes are spatial modes that have spatially inhomogeneous states of polarization, such as, radial and azimuthal polarization. They can produce smaller spot sizes and stronger longitudinal polarization components upon focusing. As a result, they are used for many applications, including optical trapping and nanoscale imaging. In this work, vector modes are used to increase the information capacity of free space optical communication via the method of optical communication referred to as mode division multiplexing. A mode (de)multiplexer for vector modes based on a liquid crystal technology referred to as a q-plate is introduced. As a proof of principle, using the mode (de)multiplexer four vector modes each carrying a 20 Gbit/s quadrature phase shift keying signal on a single wavelength channel (~1550nm), comprising an aggregate 80 Gbit/s, were transmitted ~1m over the lab table with <-16.4 dB (<2%) mode crosstalk. Bit error rates for all vector modes were measured at the forward error correction threshold with power penalties < 3.41dB.

Intramolecular energy transfer and mode-specific effects in unimolecular reactions of 1,2-difluoroethane

NASA Astrophysics Data System (ADS)

Raff, Lionel M.

1989-06-01

The unimolecular decomposition reactions of 1,2-difluoroethane upon mode-specific excitation to a total internal energy of 7.5 eV are investigated using classical trajectory methods and a previously formulated empirical potential-energy surface. The decomposition channels for 1,2-difluoroethane are, in order of importance, four-center HF elimination, C-C bond rupture, and hydrogen-atom dissociation. This order is found to be independent of the particular vibrational mode excited. Neither fluorine-atom nor F2 elimination reactions are ever observed even though these dissociation channels are energetically open. For four-center HF elimination, the average fraction of the total energy partitioned into internal HF motion varies between 0.115-0.181 depending upon the particular vibrational mode initially excited. The internal energy of the fluoroethylene product lies in the range 0.716-0.776. Comparison of the present results with those previously obtained for a random distribution of the initial 1,2-difluoroethane internal energy [J. Phys. Chem. 92, 5111 (1988)], shows that numerous mode-specific effects are present in these reactions in spite of the fact that intramolecular energy transfer rates for this system are 5.88-25.5 times faster than any of the unimolecular reaction rates. Mode-specific excitation always leads to a total decomposition rate significantly larger than that obtained for a random distribution of the internal energy. Excitation of different 1,2-difluoroethane vibrational modes is found to produce as much as a 51% change in the total decomposition rate. Mode-specific effects are also seen in the product energy partitioning. The rate coefficients for decomposition into the various channels are very sensitive to the particular mode excited. A comparison of the calculated mode-specific effects with the previously determined mode-to-mode energy transfer rate coefficients [J. Chem. Phys. 89, 5680 (1988)] shows that, to some extent, the presence of mode

Measuring the Outflow Properties of FeLoBAL Quasars

NASA Astrophysics Data System (ADS)

Dabbieri, Collin; Choi, Hyunseop; MacInnis, Francis; Leighly, Karen; Terndrup, Donald

2018-01-01

Roughly 20 percent of the quasar population shows broad absorption lines, which are indicators of an energetic wind. Within the broad absorption line class of quasars exist FeLoBAL quasars, which show strong absorption lines from the Fe II and Fe III transitions as well as other low-ionization lines. FeLoBALs are of particular interest because they are thought to possibly be a short-lived stage in a quasar's life where it expels its shroud of gas and dust. This means the winds we see from FeLoBALs are one manifestation of galactic feedback. This idea is supported by Farrah et al. (2012) who found an anti correlation between outflow strength and contribution from star formation to the total IR luminosity of the host galaxy when examining a sample of FeLoBAL quasars. We analyze the sample of 26 FeLoBALs from Farrah et al. (2012) in order to measure the properties of their outflows, including ionization, density, column density and covering fraction. The absorption and continuum profiles of these objects are modeled using SimBAL, a program which creates synthetic spectra using a grid of Cloudy models. A Monte-Carlo method is employed to determine posterior probabilities for the physical parameters of the outflow. From these probabilities we extract the distance of the outflow, the mass outflow rate and the kinetic luminosity. We demonstrate SimBAL is capable of modeling a wide range of spectral morphologies. From the 26 objects studied we observe interesting correlations between ionization parameter, distance and density. Analysis of our sample also suggests a dearth of objects with velocity widths greater than or equal to 300 km/s at distances greater than or equal to 100 parsecs.

High resolution spectroscopy of 1,2-difluoroethane in a molecular beam: A case study of vibrational mode-coupling

NASA Astrophysics Data System (ADS)

Mork, Steven W.; Miller, C. Cameron; Philips, Laura A.

1992-09-01

The high resolution infrared spectrum of 1,2-difluoroethane (DFE) in a molecular beam has been obtained over the 2978-2996 cm-1 spectral region. This region corresponds to the symmetric combination of asymmetric C-H stretches in DFE. Observed rotational fine structure indicates that this C-H stretch is undergoing vibrational mode coupling to a single dark mode. The dark mode is split by approximately 19 cm-1 due to tunneling between the two identical gauche conformers. The mechanism of the coupling is largely anharmonic with a minor component of B/C plane Coriolis coupling. Effects of centrifugal distortion along the molecular A-axis are also observed. Analysis of the fine structure identifies the dark state as being composed of C-C torsion, CCF bend, and CH2 rock. Coupling between the C-H stretches and the C-C torsion is of particular interest because DFE has been observed to undergo vibrationally induced isomerization from the gauche to trans conformer upon excitation of the C-H stretch.

Preliminary base heating environments for a generalized ALS LO2/LH2 launch vehicle, appendix 1 and 2

NASA Technical Reports Server (NTRS)

Bender, Robert L.; Reardon, John E.

1989-01-01

A secondary objective of contract NAS8-39141 is to provide base heating assessments, as required, to support Advanced Launch System (ALS) preliminary launch vehicle and propulsion system design studies. The ALS propulsion systems integration working group meeting (No. 3) recently completed in San Diego, California, focused attention on the need for base heating environment determination to provide preliminary requirements for LO2/LH2 propulsion systems currently being considered for ALS. We were requested to provide these environments for a range of possible propellant mixture and nozzle area ratios. Base heating environments can only be determined as a function of altitude when the engine operating conditions and vehicle base region geometry (engine arrangement) are known. If time dependent environments are needed to assess thermal loads, a trajectory must also be provided. These parameters are not fixed at this time since the ALS configurations and propulsion operating conditions are varied and continue to be studied by Phase B contractors. Therefore, for this study, a generalized LO2/LH2 system was selected along with a vehicle configuration consisting of a seven-engine booster and a three-engine core. MSFC provided guidance for the selection. We also selected a limited number of body points on the booster and core vehicles and engines for the environment estimates. Environments at these locations are representative of maximum heating conditions in the base region and are provided as a function of altitude only. Guidelines and assumptions for this assessment, methodology for determining the environments, and preliminary results are provided in this technical note. Refinements in the environments will be provided as the ALS design matures.

Laminarin-induced apoptosis in human colon cancer LoVo cells

PubMed Central

JI, CHEN-FENG; JI, YU-BIN

2014-01-01

A number of scientific studies have revealed that laminarin has antitumor effects. Therefore, the aim of the present study was to investigate the apoptosis of LoVo cells and the underlying mechanisms induced by laminarin. LoVo cells were treated with various concentrations of laminarin and fluorescence-inverted microscopy was used to observe the morphology of LoVo cells treated with laminarin. In addition, western blotting was performed to analyze the expression levels of death receptor (DR)4, DR5, TNF-related apoptosis-inducing ligand (TRAIL), Fas-associated protein with death domain (FADD), caspase-8, caspase-3, Bid and tBid. Flow cytometry was conducted to analyze the expressions of Bcl-2 and Bax, and spectrophotometry was performed to quantify the activity of caspases-8, -3, -6 and -7. Following the treatment of LoVo cells with laminarin for 24 h, the expression levels of DR4, DR5, TRAIL, FADD, Bid, tBid and Bax were observed to be upregulated, whereas the expression levels of pro-caspase-8, pro-caspase-3 and Bcl-2 were downregulated. In addition, the activities of casapse-8, -3, -6 and -7 were observed to increase, which was a significant difference when compared with those of the control group. Therefore, laminarin is considered to induce the apoptosis of LoVo cells, which may occur via a DR pathway, suggesting that laminarin may be a potent agent for cancer treatment. PMID:24765209

Laminarin-induced apoptosis in human colon cancer LoVo cells.

PubMed

Ji, Chen-Feng; Ji, Yu-Bin

2014-05-01

A number of scientific studies have revealed that laminarin has antitumor effects. Therefore, the aim of the present study was to investigate the apoptosis of LoVo cells and the underlying mechanisms induced by laminarin. LoVo cells were treated with various concentrations of laminarin and fluorescence-inverted microscopy was used to observe the morphology of LoVo cells treated with laminarin. In addition, western blotting was performed to analyze the expression levels of death receptor (DR)4, DR5, TNF-related apoptosis-inducing ligand (TRAIL), Fas-associated protein with death domain (FADD), caspase-8, caspase-3, Bid and tBid. Flow cytometry was conducted to analyze the expressions of Bcl-2 and Bax, and spectrophotometry was performed to quantify the activity of caspases-8, -3, -6 and -7. Following the treatment of LoVo cells with laminarin for 24 h, the expression levels of DR4, DR5, TRAIL, FADD, Bid, tBid and Bax were observed to be upregulated, whereas the expression levels of pro-caspase-8, pro-caspase-3 and Bcl-2 were downregulated. In addition, the activities of casapse-8, -3, -6 and -7 were observed to increase, which was a significant difference when compared with those of the control group. Therefore, laminarin is considered to induce the apoptosis of LoVo cells, which may occur via a DR pathway, suggesting that laminarin may be a potent agent for cancer treatment.

Analyzing speckle contrast for HiLo microscopy optimization.

PubMed

Mazzaferri, J; Kunik, D; Belisle, J M; Singh, K; Lefrançois, S; Costantino, S

2011-07-18

HiLo microscopy is a recently developed technique that provides both optical sectioning and fast imaging with a simple implementation and at a very low cost. The methodology combines widefield and speckled illumination images to obtain one optically sectioned image. Hence, the characteristics of such speckle illumination ultimately determine the quality of HiLo images and the overall performance of the method. In this work, we study how speckle contrast influence local variations of fluorescence intensity and brightness profiles of thick samples. We present this article as a guide to adjust the parameters of the system for optimizing the capabilities of this novel technology.

Analyzing speckle contrast for HiLo microscopy optimization

NASA Astrophysics Data System (ADS)

Mazzaferri, J.; Kunik, D.; Belisle, J. M.; Singh, K.; Lefrançois, S.; Costantino, S.

2011-07-01

HiLo microscopy is a recently developed technique that provides both optical sectioning and fast imaging with a simple implementation and at a very low cost. The methodology combines widefield and speckled illumination images to obtain one optically sectioned image. Hence, the characteristics of such speckle illumination ultimately determine the quality of HiLo images and the overall performance of the method. In this work, we study how speckle contrast influence local variations of fluorescence intensity and brightness profiles of thick samples. We present this article as a guide to adjust the parameters of the system for optimizing the capabilities of this novel technology.

Comparing mode-crosstalk and mode-dependent loss of laterally displaced orbital angular momentum and Hermite-Gaussian modes for free-space optical communication.

PubMed

Ndagano, Bienvenu; Mphuthi, Nokwazi; Milione, Giovanni; Forbes, Andrew

2017-10-15

There is interest in using orbital angular momentum (OAM) modes to increase the data speed of free-space optical communication. A prevalent challenge is the mitigation of mode-crosstalk and mode-dependent loss that is caused by the modes' lateral displacement at the data receiver. Here, the mode-crosstalk and mode-dependent loss of laterally displaced OAM modes (LG 0,+1 , LG 0,-1 ) are experimentally compared to that of a Hermite-Gaussian (HG) mode subset (HG 0,1 , HG 1,0 ). It is shown, for an aperture larger than the modes' waist sizes, some of the HG modes can experience less mode-crosstalk and mode-dependent loss when laterally displaced along a symmetry axis. It is also shown, over a normal distribution of lateral displacements whose standard deviation is 2× the modes' waist sizes, on average, the HG modes experience 66% less mode-crosstalk and 17% less mode-dependent loss.

G-LoSA for Prediction of Protein-Ligand Binding Sites and Structures.

PubMed

Lee, Hui Sun; Im, Wonpil

2017-01-01

Recent advances in high-throughput structure determination and computational protein structure prediction have significantly enriched the universe of protein structure. However, there is still a large gap between the number of available protein structures and that of proteins with annotated function in high accuracy. Computational structure-based protein function prediction has emerged to reduce this knowledge gap. The identification of a ligand binding site and its structure is critical to the determination of a protein's molecular function. We present a computational methodology for predicting small molecule ligand binding site and ligand structure using G-LoSA, our protein local structure alignment and similarity measurement tool. All the computational procedures described here can be easily implemented using G-LoSA Toolkit, a package of standalone software programs and preprocessed PDB structure libraries. G-LoSA and G-LoSA Toolkit are freely available to academic users at http://compbio.lehigh.edu/GLoSA . We also illustrate a case study to show the potential of our template-based approach harnessing G-LoSA for protein function prediction.

Performance Evaluation of Low Cost LoRa Modules in IoT Applications

NASA Astrophysics Data System (ADS)

Daud, Shuhaizar; Shi Yang, Teoh; Asmi Romli, Muhamad; Awang Ahmad, Zahari; Mahrom, Norfadila; Raof, Rafikha Aliana A.

2018-03-01

LoRa is a low power long range wireless communication platform that is designed as an efficient communication platform for small, low powered devices. This makes it very suitable for battery powered devices and IoT implementation. This paper evaluates some low cost LoRa modules available on the market and their suitability, energy efficiency and performance during operation. Two low cost LoRa transceiver from Semtech Industries, the SX1272 and SX1278 were tested for their power consumption and maximum transmission range. This study have evaluated the two LoRa solutions and found that the SX1278 have a better transmission range and uses lower energy compared to the SX1272 thus making it more suitable for embedded implementation as a data gateway.

Investigation of the stress distribution around a mode 1 crack with a novel strain gradient theory

NASA Astrophysics Data System (ADS)

Lederer, M.; Khatibi, G.

2017-01-01

Stress concentrations at the tip of a sharp crack have extensively been investigated in the past century. According to the calculations of Inglis, the stress ahead of a mode 1 crack shows the characteristics of a singularity. This solution is exact in the framework of linear elastic fracture mechanics (LEFM). From the viewpoint of multiscale modelling, however, it is evident that the stress at the tip of a stable crack cannot be infinite, because the strengths of atomic bonds are finite. In order to prevent the problem of this singularity, a new version of strain gradient elasticity is employed here. This theory is implemented in the commercial FEM code ABAQUS through user subroutine UEL. Convergence of the model is proved through consecutive mesh refinement. In consequence, the stresses ahead of a mode 1 crack become finite. Furthermore, the model predicts a size effect in the sense “smaller is stronger”.

Spatial-mode switchable ring fiber laser based on low mode-crosstalk all-fiber mode MUX/DEMUX

NASA Astrophysics Data System (ADS)

Ren, Fang; Yu, Jinyi; Wang, Jianping

2018-05-01

We report an all-fiber ring laser that emits linearly polarized (LP) modes based on the intracavity all-fiber mode multiplexer/demultiplexer (MUX/DEMUX). Multiple LP modes in ring fiber laser are generated by taking advantage of mode MUX/DEMUX. The all-fiber mode MUX/DEMUX are composed of cascaded mode-selective couplers (MSCs). The output lasing mode of the ring fiber laser can be switched among the three lowest-order LP modes by employing combination of a mode MUX and a simple N × 1 optical switch. The slope efficiencies, optical spectra and mode profiles are measured.

Experimental study of the effect of 2/1 classical tearing mode on (intermediate, small)-scale microturbulence in the core of an EAST L mode plasma

NASA Astrophysics Data System (ADS)

Sun, P. J.; Li, Y. D.; Ren, Y.; Zhang, X. D.; Wu, G. J.; Lyu, B.; Shi, T. H.; Xu, L. Q.; Wang, F. D.; Li, Q.; Zhang, J. Z.; Hu, L. Q.; Li, J. G.; the EAST Team

2018-02-01

In this paper, we report an experimental study of the effect of a m/n = -2/-1 (m, n being poloidal and toroidal mode number, separately) classical tearing mode on (intermediate, small)-scale microturbulence (see the definition in section 1) in the core of an EAST L mode plasma discharge. The microturbulence at different scales k ⊥ = 10, 18 and 26 cm-1 (i.e., {k}\\perp {ρ }i˜ 2, 3.6 and 5.2, respectively. Here, {ρ }i is the ion gyroradius and k ⊥ is the perpendicular wavenumber) were measured simultaneously by the EAST multi-channel tangential CO2 laser collective scattering diagnostics. Experimental results confirm that the decrease of microturbulent Doppler shift ({f}{{Doppler}}={k}t{v}t/2π ), inversely correlated to the increase of microturbulent mean frequency (defined in equation (1)), is due to the 2/1 tearing mode. Temporal evolution of frequency-integrated spectral power S tot of microturbulence, found to be correlated with the width of 2/1 magnetic island, suggests the modulation effect on microturbulence by the tearing mode beyond Doppler shift effect. Modulation effects on microturbulence by the tearing mode are further demonstrated by the correlation between microturbulent envelope and magnetic fluctuations.

1.9 μm square-wave passively Q-witched mode-locked fiber laser.

PubMed

Ma, Wanzhuo; Wang, Tianshu; Su, Qingchao; Wang, Furen; Zhang, Jing; Wang, Chengbo; Jiang, Huilin

2018-05-14

We propose and demonstrate the operation of Q-switched mode-locked square-wave pulses in a thulium-holmium co-doped fiber laser. By using a nonlinear amplifying loop mirror, continuous square-wave dissipative soliton resonance pulse is obtained with 4.4 MHz repetition rate. With the increasing pump power, square-wave pulse duration can be broadened from 1.7 ns to 3.2 ns. On such basis Q-switched mode-locked operation is achieved by properly setting the pump power and the polarization controllers. The internal mode-locked pulses in Q-switched envelope still keep square-wave type. The Q-switched repetition rate can be varied from 41.6 kHz to 74 kHz by increasing pump power. The corresponding average single-pulse energy increases from 2.67 nJ to 5.2 nJ. The average peak power is also improved from 0.6 W to 1.1 W when continuous square-wave operation is changed into Q-switched mode-locked operation. It indicates that Q-switched mode-locked operation is an effective method to increase the square-wave pulse energy and peak power.

LoTi Turns Up the Heat!

ERIC Educational Resources Information Center

Moersch, Christopher

2010-01-01

When LoTi was first introduced in 1994 as the Levels of Technology Implementation framework, the intent was to create a tool to help district leadership quantify how teachers were using technology in the classroom. After serving the past 15 years as a research framework, self-reporting technology integration survey, and school improvement model,…

LoC-SERS toward clinical application: quantification of antibiotics in human urine samples

NASA Astrophysics Data System (ADS)

Hidi, I. J.; Jahn, M.; Weber, K.; Pletz, M. W.; Bocklitz, T. W.; Cialla-May, D.; Popp, J.

2017-02-01

The determination of the concentration of xenobiotics in biological matrix followed by the change of the prescribing procedure plays a major role in the transition from general to personalized medicine. For this contribution, human urine samples collected from healthy volunteers and from patients having urinary tract infection were used as biological matrix to assess the potential and limitation of LoC-SERS to detected levofloxacin and nitroxoline. The determination of both antibiotics at clinically relevant concentrations, 1.38 mM +/- 0.68 mM for levofloxacin and 10-40 µM for nitroxoline, will be presented. For quantification purposes the standard addition method is combined with LoC-SERS.

Helicon modes in uniform plasmas. I. Low m modes

NASA Astrophysics Data System (ADS)

Urrutia, J. M.; Stenzel, R. L.

2015-09-01

Helicons are whistler modes with azimuthal wave numbers. They arise in bounded gaseous and solid state plasmas, but the present work shows that very similar modes also exist in unbounded uniform plasmas. The antenna properties determine the mode structure. A simple antenna is a magnetic loop with dipole moment aligned either along or across the ambient background magnetic field B0. For such configurations, the wave magnetic field has been measured in space and time in a large and uniform laboratory plasma. The observed wave topology for a dipole along B0 is similar to that of an m = 0 helicon mode. It consists of a sequence of alternating whistler vortices. For a dipole across B0, an m = 1 mode is excited which can be considered as a transverse vortex which rotates around B0. In m = 0 modes, the field lines are confined to each half-wavelength vortex while for m = 1 modes they pass through the entire wave train. A subset of m = 1 field lines forms two nested helices which rotate in space and time like corkscrews. Depending on the type of the antenna, both m = + 1 and m = -1 modes can be excited. Helicons in unbounded plasmas also propagate transverse to B0. The transverse and parallel wave numbers are about equal and form oblique phase fronts as in whistler Gendrin modes. By superimposing small amplitude fields of several loop antennas, various antenna combinations have been created. These include rotating field antennas, helical antennas, and directional antennas. The radiation efficiency is quantified by the radiation resistance. Since helicons exist in unbounded laboratory plasmas, they can also arise in space plasmas.

Resonant intersubband polariton-LO phonon scattering in an optically pumped polaritonic device

NASA Astrophysics Data System (ADS)

Manceau, J.-M.; Tran, N.-L.; Biasiol, G.; Laurent, T.; Sagnes, I.; Beaudoin, G.; De Liberato, S.; Carusotto, I.; Colombelli, R.

2018-05-01

We report experimental evidence of longitudinal optical (LO) phonon-intersubband polariton scattering processes under resonant injection of light. The scattering process is resonant with both the initial (upper polariton) and final (lower polariton) states and is induced by the interaction of confined electrons with longitudinal optical phonons. The system is optically pumped with a mid-IR laser tuned between 1094 cm-1 and 1134 cm-1 (λ = 9.14 μm and λ = 8.82 μm). The demonstration is provided for both GaAs/AlGaAs and InGaAs/AlInAs doped quantum well systems whose intersubband plasmon lies at a wavelength of ≈10 μm. In addition to elucidating the microscopic mechanism of the polariton-phonon scattering, it is found to differ substantially from the standard single particle electron-LO phonon scattering mechanism, and this work constitutes an important step towards the hopefully forthcoming demonstration of an intersubband polariton laser.

Volumetric HiLo microscopy employing an electrically tunable lens.

PubMed

Philipp, Katrin; Smolarski, André; Koukourakis, Nektarios; Fischer, Andreas; Stürmer, Moritz; Wallrabe, Ulrike; Czarske, Jürgen W

2016-06-27

Electrically tunable lenses exhibit strong potential for fast motion-free axial scanning in a variety of microscopes. However, they also lead to a degradation of the achievable resolution because of aberrations and misalignment between illumination and detection optics that are induced by the scan itself. Additionally, the typically nonlinear relation between actuation voltage and axial displacement leads to over- or under-sampled frame acquisition in most microscopic techniques because of their static depth-of-field. To overcome these limitations, we present an Adaptive-Lens-High-and-Low-frequency (AL-HiLo) microscope that enables volumetric measurements employing an electrically tunable lens. By using speckle-patterned illumination, we ensure stability against aberrations of the electrically tunable lens. Its depth-of-field can be adjusted a-posteriori and hence enables to create flexible scans, which compensates for irregular axial measurement positions. The adaptive HiLo microscope provides an axial scanning range of 1 mm with an axial resolution of about 4 μm and sub-micron lateral resolution over the full scanning range. Proof of concept measurements at home-built specimens as well as zebrafish embryos with reporter gene-driven fluorescence in the thyroid gland are shown.

TSS-1R Failure Mode Evaluation

NASA Technical Reports Server (NTRS)

Vaughn, Jason A.; McCollum, Matthew B.; Kamenetzky, Rachel R.

1997-01-01

Soon after the break of the tether during the Tethered Satellite System (TSS-1R) mission in February, 1996, a Tiger Team was assembled at the George C. Marshall Space Flight Center to determine the tether failure mode. One possible failure scenario was the Kevlar' strength member of the tether failed because of degradation due to electrical discharge or electrical arcing. During the next several weeks, extensive electrical discharge testing in low vacuum and plasma environments was conducted in an attempt to reproduce the electrical activity recorded by on-board science instruments during the mission. The results of these tests are presented in this paper.

Impact of foliage on LoRa 433MHz propagation in tropical environment

NASA Astrophysics Data System (ADS)

Ahmad, Khairol Amali; Salleh, Mohd Sharil; Segaran, Jivitraa Devi; Hashim, Fakroul Ridzuan

2018-02-01

LoRa is being considered as one of the promising system for Low-Power-Wide-Area-Network (LPWAN) to support the growth of Internet of Things (IoT) applications. Designed to operate in the industrial, scientific and medical (ISM) bands, LoRa had been tested and evaluated mainly in Europe and US in the 868 MHz and 915 MHz modulation bands. Using chirp spread spectrum technology, LoRa is expected to be robust against degredation. This paper provides some early results in the performance of LoRa signal propagation of 433 MHz modulation in tropical foliage environments.

The AhR is involved in the regulation of LoVo cell proliferation through cell cycle-associated proteins.

PubMed

Yin, Jiuheng; Sheng, Baifa; Han, Bin; Pu, Aimin; Yang, Kunqiu; Li, Ping; Wang, Qimeng; Xiao, Weidong; Yang, Hua

2016-05-01

Some ingredients in foods can activate the aryl hydrocarbon receptor (AhR) and arrest cell proliferation. In this study, we hypothesized that 6-formylindolo [3, 2-b] carbazole (FICZ) arrests the cell cycle in LoVo cells (a colon cancer line) through the AhR. The AhR agonist FICZ and the AhR antagonist CH223191 were used to treat LoVo cells. Real-time PCR and Western blot analyses were performed to detect the expression of the AhR, CYP1A1, CDK4, cyclinD1, cyclin E, CDK2, P27, and pRb. The distribution and activation of the AhR were detected with immunofluorescence. A 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay and flow cytometric analysis were performed to measure cell viability, cell cycle stage, and apoptosis. Our results show that FICZ inhibited LoVo cell proliferation by inducing G1 cell cycle arrest but had no effect on epithelial apoptosis. Further analysis found that FICZ downregulated cyclinD1 and upregulated p27 expression to arrest Rb phosphorylation. The downregulation of cyclinD1 and upregulation of p27 were abolished by co-treatment with CH223191. We conclude that the AhR, when activated by FICZ (an endogenous AhR ligand), can arrest the cell cycle and block LoVo cell proliferation. © 2016 International Federation for Cell Biology.

Liquid oxygen (LO2) propellant conditioning concept testing

NASA Technical Reports Server (NTRS)

Perry, Gretchen L. E.; Orth, Michael S.; Mehta, Gopal K.

1993-01-01

Testing of a simplified LO2 propellant conditioning concept for future expendable launch vehicles is discussed. Four different concepts are being investigated: no-bleed, low-bleed, use of a recirculation line, and He bubbling. A full-scale test article, which is a facsimile of a propellant feed duct with an attached section to simulate heat input from an LO2 turbopump, is to be tested at the Cold Flow Facility of the Marshall Space Flight Center West Test Area. Work to date includes: design and fabrication of the test article, design of the test facility and initial fabrication, development of a test matrix and test procedures, initial predictions of test output, and heat leak calibration and heat exchanger tests on the test articles.

35 GHz mode-locking of 1.3 μm quantum dot lasers

NASA Astrophysics Data System (ADS)

Kuntz, M.; Fiol, G.; Lämmlin, M.; Bimberg, D.; Thompson, M. G.; Tan, K. T.; Marinelli, C.; Penty, R. V.; White, I. H.; Ustinov, V. M.; Zhukov, A. E.; Shernyakov, Yu. M.; Kovsh, A. R.

2004-08-01

35GHz passive mode-locking of 1.3μm (InGa)As/GaAs quantum dot lasers is reported. Hybrid mode-locking was achieved at frequencies up to 20GHz. The minimum pulse width of the Fourier-limited pulses was 7ps with a peak power of 6mW. Low uncorrelated timing jitter below 1ps was found in cross correlation experiments. High-frequency operation of the lasers was eased by a ridge waveguide design that includes etching through the active layer.

Finite Larmor radius effects on the (m = 2, n = 1) cylindrical tearing mode

NASA Astrophysics Data System (ADS)

Chen, Y.; Chowdhury, J.; Parker, S. E.; Wan, W.

2015-04-01

New field solvers are developed in the gyrokinetic code GEM [Chen and Parker, J. Comput. Phys. 220, 839 (2007)] to simulate low-n modes. A novel discretization is developed for the ion polarization term in the gyrokinetic vorticity equation. An eigenmode analysis with finite Larmor radius effects is developed to study the linear resistive tearing mode. The mode growth rate is shown to scale with resistivity as γ ˜ η1/3, the same as the semi-collisional regime in previous kinetic treatments [Drake and Lee, Phys. Fluids 20, 1341 (1977)]. Tearing mode simulations with gyrokinetic ions are verified with the eigenmode calculation.

Functional comparison of the reverse mode of Na+/Ca2+ exchangers NCX1.1 and NCX1.5 expressed in CHO cells.

PubMed

Long, Yan; Wang, Wei-ping; Yuan, Hui; Ma, Shi-ping; Feng, Nan; Wang, Ling; Wang, Xiao-liang

2013-05-01

To investigate the reverse mode function of Na(+)/Ca(2+) exchangers NCX1.1 and NCX1.5 expressed in CHO cells as well as their modulations by PKC and PKA. CHO-K1 cells were transfected with pcDNA3.1 (+) plasmid carrying cDNA of rat cardiac NCX1.1 and brain NCX1.5. The expression of NCX1.1 and NCX1.5 was examined using Western blot analysis. The intracellular Ca(2+) level ([Ca(2+)]i) was measured using Ca(2+) imaging. Whole-cell NCX currents were recorded using patch-clamp technique. Reverse mode NCX activity was elicited by perfusion with Na(+)-free medium. Ca(2+) paradox was induced by Ca(2+)-free EBSS medium, followed by Ca(2+)-containing solution (1.8 or 3.8 mmol/L CaCl2). The protein levels of NCX1.1 and NCX1.5 expressed in CHO cells had no significant difference. The reverse modes of NCX1.1 and NCX1.5 in CHO cells exhibited a transient increase of [Ca(2+)]i, which was followed by a Ca(2+) level plateau at higher external Ca(2+) concentrations. In contrast, the wild type CHO cells showed a steady increase of [Ca(2+)]i at higher external Ca(2+) concentrations. The PKC activator PMA (0.3-10 μmol/L) and PKA activator 8-Br-cAMP (10-100 μmol/L) significantly enhanced the reverse mode activity of NCX1.1 and NCX1.5 in CHO cells. NCX1.1 was 2.4-fold more sensitive to PKC activation than NCX1.5, whereas the sensitivity of the two NCX isoforms to PKA activation had no difference. Both PKC- and PKA-enhanced NCX reverse mode activities in CHO cells were suppressed by NCX inhibitor KB-R7943 (30 μmol/L). Both NCX1.1 and NCX1.5 are functional in regulating and maintaining stable [Ca(2+)]i in CHO cells and differentially regulated by PKA and PKC. The two NCX isoforms might be useful drug targets for heart and brain protection.

Fast optically sectioned fluorescence HiLo endomicroscopy.

PubMed

Ford, Tim N; Lim, Daryl; Mertz, Jerome

2012-02-01

We describe a nonscanning, fiber bundle endomicroscope that performs optically sectioned fluorescence imaging with fast frame rates and real-time processing. Our sectioning technique is based on HiLo imaging, wherein two widefield images are acquired under uniform and structured illumination and numerically processed to reject out-of-focus background. This work is an improvement upon an earlier demonstration of widefield optical sectioning through a flexible fiber bundle. The improved device features lateral and axial resolutions of 2.6 and 17 μm, respectively, a net frame rate of 9.5 Hz obtained by real-time image processing with a graphics processing unit (GPU) and significantly reduced motion artifacts obtained by the use of a double-shutter camera. We demonstrate the performance of our system with optically sectioned images and videos of a fluorescently labeled chorioallantoic membrane (CAM) in the developing G. gallus embryo. HiLo endomicroscopy is a candidate technique for low-cost, high-speed clinical optical biopsies.

Fast optically sectioned fluorescence HiLo endomicroscopy

NASA Astrophysics Data System (ADS)

Ford, Tim N.; Lim, Daryl; Mertz, Jerome

2012-02-01

We describe a nonscanning, fiber bundle endomicroscope that performs optically sectioned fluorescence imaging with fast frame rates and real-time processing. Our sectioning technique is based on HiLo imaging, wherein two widefield images are acquired under uniform and structured illumination and numerically processed to reject out-of-focus background. This work is an improvement upon an earlier demonstration of widefield optical sectioning through a flexible fiber bundle. The improved device features lateral and axial resolutions of 2.6 and 17 μm, respectively, a net frame rate of 9.5 Hz obtained by real-time image processing with a graphics processing unit (GPU) and significantly reduced motion artifacts obtained by the use of a double-shutter camera. We demonstrate the performance of our system with optically sectioned images and videos of a fluorescently labeled chorioallantoic membrane (CAM) in the developing G. gallus embryo. HiLo endomicroscopy is a candidate technique for low-cost, high-speed clinical optical biopsies.

Fast optically sectioned fluorescence HiLo endomicroscopy

PubMed Central

Lim, Daryl; Mertz, Jerome

2012-01-01

Abstract. We describe a nonscanning, fiber bundle endomicroscope that performs optically sectioned fluorescence imaging with fast frame rates and real-time processing. Our sectioning technique is based on HiLo imaging, wherein two widefield images are acquired under uniform and structured illumination and numerically processed to reject out-of-focus background. This work is an improvement upon an earlier demonstration of widefield optical sectioning through a flexible fiber bundle. The improved device features lateral and axial resolutions of 2.6 and 17 μm, respectively, a net frame rate of 9.5 Hz obtained by real-time image processing with a graphics processing unit (GPU) and significantly reduced motion artifacts obtained by the use of a double-shutter camera. We demonstrate the performance of our system with optically sectioned images and videos of a fluorescently labeled chorioallantoic membrane (CAM) in the developing G. gallus embryo. HiLo endomicroscopy is a candidate technique for low-cost, high-speed clinical optical biopsies. PMID:22463023

Tamoxifen-loaded lecithin organogel (LO) for topical application: Development, optimization and characterization.

PubMed

Bhatia, Amit; Singh, Bhupinder; Raza, Kaisar; Wadhwa, Sheetu; Katare, Om Prakash

2013-02-28

Lecithin organogels (LOs) are semi-solid systems with immobilized organic liquid phase in 3-D network of self-assembled gelators. This paper attempts to study the various attributes of LOs, starting from selection of materials, optimization of influential components to LO specific characterization. After screening of various components (type of gelators, organic and aqueous phase) and construction of phase diagrams, a D-optimal mixture design was employed for the systematic optimization of the LO composition. The response surface plots were constructed for various response variables, viz. viscosity, gel strength, spreadability and consistency index. The optimized LO composition was searched employing overlay plots. Subsequent validation of the optimization study employing check-point formulations, located using grid search, indicated high degree of prognostic ability of the experimental design. The optimized formulation was characterized for morphology, drug content, rheology, spreadability, pH, phase transition temperatures, and physical and chemical stability. The outcomes of the study were interesting showing high dependence of LO attributes on the type and amount of phospholipid, Poloxamer™, auxillary gelators and organic solvent. The optimized LO was found to be quite stable, easily applicable and biocompatible. The findings of the study can be utilized for the development of LO systems of other drugs for the safer and effective topical delivery. Crown Copyright © 2013. Published by Elsevier B.V. All rights reserved.

Enhanced light scattering of the forbidden longitudinal optical phonon mode studied by micro-Raman spectroscopy on single InN nanowires.

PubMed

Schäfer-Nolte, E O; Stoica, T; Gotschke, T; Limbach, F A; Sutter, E; Sutter, P; Grützmacher, D; Calarco, R

2010-08-06

In the literature, there are controversies on the interpretation of the appearance in InN Raman spectra of a strong scattering peak in the energy region of the unscreened longitudinal optical (LO) phonons, although a shift caused by the phonon-plasmon interaction is expected for the high conductance observed in this material. Most measurements on light scattering are performed on ensembles of InN nanowires (NWs). However, it is important to investigate the behavior of individual nanowires and here we report on micro-Raman measurements on single nanowires. When changing the polarization direction of the incident light from parallel to perpendicular to the wire, the expected reduction of the Raman scattering was observed for transversal optical (TO) and E(2) phonon scattering modes, while a strong symmetry-forbidden LO mode was observed independently on the laser polarization direction. Single Mg- and Si-doped crystalline InN nanowires were also investigated. Magnesium doping results in a sharpening of the Raman peaks, while silicon doping leads to an asymmetric broadening of the LO peak. The results can be explained based on the influence of the high electron concentration with a strong contribution of the surface accumulation layer and the associated internal electric field.

Design and Development of Multi-Transceiver Lorafi Board consisting LoRa and ESP8266-Wifi Communication Module

NASA Astrophysics Data System (ADS)

Azmi, Noraini; Sudin, Sukhairi; Munirah Kamarudin, Latifah; Zakaria, Ammar; Visvanathan, Retnam; Chew Cheik, Goh; Mamduh Syed Zakaria, Syed Muhammad; Abdullah Alfarhan, Khudhur; Badlishah Ahmad, R.

2018-03-01

The advancement of Micro-Electro-Mechanical-Systems (MEMS), microcontroller technologies and the idea of Internet of Things (IoT) motivates the development of wireless modules (e.g. WiFi, Bluetooth, Zigbee, and LoRa) that are small and affordable. This paper aims to provide detailed information on the development of the LoRaFi board. The LoRaFi 1.0 is a multi-protocol communication board developed by Centre of Excellence for Advanced Sensor Technology (CEASTech). The board was developed for but not limited to monitor the indoor air quality. The board comprises two different wireless communication modules namely, Long-range technology (LoRa) and WiFi (using ESP8266). The board can be configured to communicate either using LoRa or WiFi or both. The board has been tested and the wireless communication operates successfully. Apart from LoRa, WiFi enables data to be forwarded to the cloud/server where the data can be stored for further data analysis. This helps provide users with real-time information on their smartphones or other applications. In the future, researchers will conduct tests to investigate the communication link quality. Newer version with reduced board size and additional wireless communication module will be developed in the future as to increase board flexibility and widen the range of applications that can use the board.

Intrinsic hybrid modes in a corrugated conical horn

NASA Astrophysics Data System (ADS)

Dendane, A.; Arnold, J. M.

1988-08-01

Computational requirements for the generation of intrinsic modes in a nonseparable waveguide geometry requiring a full vector field description with anistropic impedance boundaries were derived. Good agreement is shown between computed and measured radiation patterns in copolar and crosspolar configurations. This agreement establishes that the intrinsic mode correctly accounts for the local normal mode conversion which takes place along the horn in a conventional mode coupling scheme, at least for cone semiangles up to 15 deg. The advantage of the intrinsic mode formulation over the conventional mode-coupling theory is that, to construct a single intrinsic mode throughout the horn, only one local normal mode field is required at each cross section, whereas mode conversion from the HE11 mode would require all the HE1n modes to be known at each cross section. The intrinsic mode accounts also for fields which would appear as backward modes in coupled-mode theory. A complete coupled-mode theory solution requires the inversion of a large matrix at each cross section, whereas the intrinsic mode can be constructed explicitly using a simple Fourier-like integral; the perturbation solution of Dragone (1977) is difficult to make rigorous.

Widefield fluorescence sectioning with HiLo microscopy.

PubMed

Mertz, Jerome; Lim, Daryl; Chu, Kengyeh K; Bozinovic, Nenad; Ford, Timothy

2009-01-01

HiLo microscopy is a widefield fluorescence imaging technique that provides depth discrimination by combining two images, one with non-uniform illumination and one with uniform illumination. We discuss the theory of this technique and a variety of practical implementations in brain-tissue imaging and fluorescence endomicroscopy.

Processing mode during repetitive thinking in socially anxious individuals: evidence for a maladaptive experiential mode.

PubMed

Wong, Quincy J J; Moulds, Michelle L

2012-12-01

Evidence from the depression literature suggests that an analytical processing mode adopted during repetitive thinking leads to maladaptive outcomes relative to an experiential processing mode. To date, in socially anxious individuals, the impact of processing mode during repetitive thinking related to an actual social-evaluative situation has not been investigated. We thus tested whether an analytical processing mode would be maladaptive relative to an experiential processing mode during anticipatory processing and post-event rumination. High and low socially anxious participants were induced to engage in either an analytical or experiential processing mode during: (a) anticipatory processing before performing a speech (Experiment 1; N = 94), or (b) post-event rumination after performing a speech (Experiment 2; N = 74). Mood, cognition, and behavioural measures were employed to examine the effects of processing mode. For high socially anxious participants, the modes had a similar effect on self-reported anxiety during both anticipatory processing and post-event rumination. Unexpectedly, relative to the analytical mode, the experiential mode led to stronger high standard and conditional beliefs during anticipatory processing, and stronger unconditional beliefs during post-event rumination. These experiments are the first to investigate processing mode during anticipatory processing and post-event rumination. Hence, these results are novel and will need to be replicated. These findings suggest that an experiential processing mode is maladaptive relative to an analytical processing mode during repetitive thinking characteristic of socially anxious individuals. Copyright © 2012 Elsevier Ltd. All rights reserved.

Mapping the droplet transfer modes for an ER100S-1 GMAW electrode

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heald, P.R.; Madigan, R.B.; Siewert, T.A.

1994-02-01

Welds were made with a 1.2-mm-diameter AWS ER100S-1 electrode using Ar-2% O[sub 2] shielding gas to map the effects of contact-tube-to-work distance (13, 19 and 25 mm), current, voltage, and wire feed rate on metal transfer. The droplet transfer modes were identified for each map by both the sound of the arc and images from a laser back-lit high-speed video system. The modes were correlated to digital records of the voltage and current fluctuations. The maps contain detailed information on the spray transfer mode, including the boundaries of drop spray, streaming spray and rotating spray modes. The metal transfer modemore » boundaries shifted with an increase in contact-tube-to-work distance. Increasing the contact-tube-to-work distance from 13 to 19 mm resulted in a 15 mm/s increase in the wire feet rate for the globular-to-drop-spray transition.« less

A local framework for calculating coupled cluster singles and doubles excitation energies (LoFEx-CCSD)

DOE PAGES

Baudin, Pablo; Bykov, Dmytro; Liakh, Dmitry I.; ...

2017-02-22

Here, the recently developed Local Framework for calculating Excitation energies (LoFEx) is extended to the coupled cluster singles and doubles (CCSD) model. In the new scheme, a standard CCSD excitation energy calculation is carried out within a reduced excitation orbital space (XOS), which is composed of localised molecular orbitals and natural transition orbitals determined from time-dependent Hartree–Fock theory. The presented algorithm uses a series of reduced second-order approximate coupled cluster singles and doubles (CC2) calculations to optimise the XOS in a black-box manner. This ensures that the requested CCSD excitation energies have been determined to a predefined accuracy compared tomore » a conventional CCSD calculation. We present numerical LoFEx-CCSD results for a set of medium-sized organic molecules, which illustrate the black-box nature of the approach and the computational savings obtained for transitions that are local compared to the size of the molecule. In fact, for such local transitions, the LoFEx-CCSD scheme can be applied to molecular systems where a conventional CCSD implementation is intractable.« less

Higgs boson gluon-fusion production beyond threshold in N 3LO QCD

DOE PAGES

Anastasiou, Charalampos; Duhr, Claude; Dulat, Falko; ...

2015-03-18

In this study, we compute the gluon fusion Higgs boson cross-section at N 3LO through the second term in the threshold expansion. This calculation constitutes a major milestone towards the full N 3LO cross section. Our result has the best formal accuracy in the threshold expansion currently available, and includes contributions from collinear regions besides subleading corrections from soft and hard regions, as well as certain logarithmically enhanced contributions for general kinematics. We use our results to perform a critical appraisal of the validity of the threshold approximation at N 3LO in perturbative QCD.

Quadrupole decay strength of the M1 scissors mode

NASA Astrophysics Data System (ADS)

Beck, T.; Beller, J.; Derya, V.; Gayer, U.; Isaak, J.; Löher, B.; Mertes, L.; Pietralla, N.; Ries, P.; Romig, C.; Savran, D.; Scheck, M.; Tornow, W.; Weller, H. R.; Werner, V.; Zweidinger, M.

2015-10-01

The E2/M1 multipole mixing ratio δ1→2 of the 1sc +→21+ transition of Gd was determined using results from high-statistics photon scattering. This provides a possibility for a new approach on the search of Jsc + members of the rotational band built on the scissors mode. By application of Alaga's rule, which is justifiable as 156Gd is a well-deformed rotor with good K quantum number, a transition strength of B (E 2 ;2sc +→01+)=0.034 (13 ) W.u. is estimated.

Increased levels of CCR7(lo)PD-1(hi) CXCR5+ CD4+ T cells, and associated factors Bcl-6, CXCR5, IL-21 and IL-6 contribute to repeated implantation failure.

PubMed

Gong, Qiaoqiao; Zhu, Yuejie; Pang, Nannan; Ai, Haiquan; Gong, Xiaoyun; La, Xiaolin; Ding, Jianbing

2017-12-01

In vitro fertilization-embryo transfer (IVF-ET) can be used by infertile couples to assist with reproduction; however, failure of the embryo to implant into the endometrial lining results in failure of the IVF treatment. The present study investigated the expression of chemokine receptor 7 (CCR7)(lo) programmed death-1(PD-1)(hi) chemokine receptor type 5 (CXCR5) + cluster of differentiation 4 (CD4) + T cells and associated factors in patients with repeated implantation failure (RIF). A total of 30 females with RIF and 30 healthy females were enrolled in the current study. Flow cytometry was used to detect the proportion of CCR7(lo)PD-1(hi) CXCR5 + CD4 + T cells in the peripheral blood. Cytokine bead arrays were performed to detect the levels of interleukin (IL)-6, -4 and -2 in the serum. ELISAs were used to detect the level of IL-21 in the serum. Quantitative real time polymerase chain reaction analysis and immunohistochemistry were used to investigate the expression of B-cell lymphoma 6 (Bcl-6), chemokine receptor type 5 (CXCR5) and IL-21 in the endometrium. The results revealed that the percentage of CCR7(lo)PD-1(hi) CXCR5 + CD4 + T cells was increased in the RIF group compared with the control group during the mid luteal phase. The mRNA and protein levels of Bcl-6, IL-21 and CXCR5 in the endometrium and the concentrations of IL-21 and IL-6 in the serum were significantly increased in the RIF group; however, no significant difference was observed between the two groups in regards to the expression of IL-4 and IL-2. Furthermore, a significant positive correlation was identified between the percentage of CCR7(lo)PD-1(hi) CXCR5 + CD4 + T cells and IL-21 and IL-6 levels. The expression of IL-21 also had a positive correlation with Bcl-6 and CXCR5 expression in the RIF group. These results suggest that increased levels of CCR7(lo)PD-1(hi) CXCR5 + CD4 + T cells and associated factors contribute to RIF and could therefore be a potential therapeutic target.

Two modes of polyamine block regulating the cardiac inward rectifier K+ current IK1 as revealed by a study of the Kir2.1 channel expressed in a human cell line.

PubMed

Ishihara, Keiko; Ehara, Tsuguhisa

2004-04-01

The strong inward rectifier K(+) current, I(K1), shows significant outward current amplitude in the voltage range near the reversal potential and thereby causes rapid repolarization at the final phase of cardiac action potentials. However, the mechanism that generates the outward I(K1) is not well understood. We recorded currents from the inside-out patches of HEK 293T cells that express the strong inward rectifier K(+) channel Kir2.1 and studied the blockage of the currents caused by cytoplasmic polyamines, namely, spermine and spermidine. The outward current-voltage (I-V) relationships of Kir2.1, obtained with 5-10 microm spermine or 10-100 microm spermidine, were similar to the steady-state outward I-V relationship of I(K1), showing a peak at a level that is approximately 20 mV more positive than the reversal potential, with a negative slope at more positive voltages. The relationships exhibited a plateau or a double-hump shape with 1 microm spermine/spermidine or 0.1 microm spermine, respectively. In the chord conductance-voltage relationships, there were extra conductances in the positive voltage range, which could not be described by the Boltzmann relations fitting the major part of the relationships. The extra conductances, which generated most of the outward currents in the presence of 5-10 microm spermine or 10-100 microm spermidine, were quantitatively explained by a model that considered two populations of Kir2.1 channels, which were blocked by polyamines in either a high-affinity mode (Mode 1 channel) or a low-affinity mode (Mode 2 channel). Analysis of the inward tail currents following test pulses indicated that the relief from the spermine block of Kir2.1 consisted of an exponential component and a virtually instantaneous component. The fractions of the two components nearly agreed with the fractions of the blockages in Mode 1 and Mode 2 calculated by the model. The estimated proportion of Mode 1 channels to total channels was 0.9 with 0.1-10 microm

LoCuSS: Testing hydrostatic equilibrium in galaxy clusters

NASA Astrophysics Data System (ADS)

Smith, G. P.; Mazzotta, P.; Okabe, N.; Ziparo, F.; Mulroy, S. L.; Babul, A.; Finoguenov, A.; McCarthy, I. G.; Lieu, M.; Bahé, Y. M.; Bourdin, H.; Evrard, A. E.; Futamase, T.; Haines, C. P.; Jauzac, M.; Marrone, D. P.; Martino, R.; May, P. E.; Taylor, J. E.; Umetsu, K.

2016-02-01

We test the assumption of hydrostatic equilibrium in an X-ray luminosity selected sample of 50 galaxy clusters at 0.15 < z < 0.3 from the Local Cluster Substructure Survey (LoCuSS). Our weak-lensing measurements of M500 control systematic biases to sub-4 per cent, and our hydrostatic measurements of the same achieve excellent agreement between XMM-Newton and Chandra. The mean ratio of X-ray to lensing mass for these 50 clusters is β_X= 0.95± 0.05, and for the 44 clusters also detected by Planck, the mean ratio of Planck mass estimate to LoCuSS lensing mass is β_P= 0.95± 0.04. Based on a careful like-for-like analysis, we find that LoCuSS, the Canadian Cluster Comparison Project, and Weighing the Giants agree on β_P ≃ 0.9-0.95 at 0.15 < z < 0.3. This small level of hydrostatic bias disagrees at ˜5σ with the level required to reconcile Planck cosmology results from the cosmic microwave background and galaxy cluster counts.

A Current-Mode Common-Mode Feedback Circuit (CMFB) with Rail-to-Rail Operation

NASA Astrophysics Data System (ADS)

Suadet, Apirak; Kasemsuwan, Varakorn

2011-03-01

This paper presents a current-mode common-mode feedback (CMFB) circuit with rail-to-rail operation. The CMFB is a stand-alone circuit, which can be connected to any low voltage transconductor without changing or upsetting the existing circuit. The proposed CMFB employs current mirrors, operating as common-mode detector and current amplifier to enhance the loop gain of the CMFB. The circuit employs positive feedback to enhance the output impedance and gain. The circuit has been designed using a 0.18 μm CMOS technology under 1V supply and analyzed using HSPICE with BSIM3V3 device models. A pseudo-differential amplifier using two common sources and the proposed CMFB shows rail to rail output swing (± 0.7 V) with low common-mode gain (-36 dB) and power dissipation of 390 μW.

Hyperpolarized 13C pyruvate mouse brain metabolism with absorptive-mode EPSI at 1 T

NASA Astrophysics Data System (ADS)

Miloushev, Vesselin Z.; Di Gialleonardo, Valentina; Salamanca-Cardona, Lucia; Correa, Fabian; Granlund, Kristin L.; Keshari, Kayvan R.

2017-02-01

The expected signal in echo-planar spectroscopic imaging experiments was explicitly modeled jointly in spatial and spectral dimensions. Using this as a basis, absorptive-mode type detection can be achieved by appropriate choice of spectral delays and post-processing techniques. We discuss the effects of gradient imperfections and demonstrate the implementation of this sequence at low field (1.05 T), with application to hyperpolarized [1-13C] pyruvate imaging of the mouse brain. The sequence achieves sufficient signal-to-noise to monitor the conversion of hyperpolarized [1-13C] pyruvate to lactate in the mouse brain. Hyperpolarized pyruvate imaging of mouse brain metabolism using an absorptive-mode EPSI sequence can be applied to more sophisticated murine disease and treatment models. The simple modifications presented in this work, which permit absorptive-mode detection, are directly translatable to human clinical imaging and generate improved absorptive-mode spectra without the need for refocusing pulses.

Ultracompact 1×4 TM-polarized beam splitter based on photonic crystal surface mode.

PubMed

Jiang, Bin; Zhang, Yejin; Wang, Yufei; Liu, Anjin; Zheng, Wanhua

2012-05-01

We provide an improved surface-mode photonic crystal (PhC) T-junction waveguide, combine it with an improved PhC bandgap T-junction waveguide, and then provide an ultracompact 1×4 TM-polarized beam splitter. The energy is split equally into the four output waveguides. The maximal transmission ratio of each output waveguide branch equals 24.7%, and the corresponding total transmission ratio of the ultracompact 1×4 beam splitter equals 98.8%. The normalized frequency of maximal transmission ratio is 0.397(2πc/a), and the bandwidth of the ultracompact 1×4 TM-polarized beam splitter is 0.0106(2πc/a). To the best of our knowledge, this is the first time such a high-efficiency 1×4 beam splitter exploiting the nonradiative surface mode as a guided mode has been proposed. Although we only employed a 1×4 beam splitter, our design can easily be extended to other 1×n beam splitters.

Mode 1 stress intensity factors for round compact specimens

NASA Technical Reports Server (NTRS)

Gross, B.

1976-01-01

The mode 1 stress intensity factors were computed for round compact specimens by the boundary collocation method. Results are presented for ratios A sub T/R sub 0 in the range 0.3 to 0.8, where A sub t is the distance from the specimen center to the crack tip for a specimen of diameter 2R sub 0.

Lommel modes

NASA Astrophysics Data System (ADS)

Kovalev, Alexey A.; Kotlyar, Victor V.

2015-03-01

We study a non-paraxial family of nondiffracting laser beams whose complex amplitude is proportional to an n-th order Lommel function of two variables. These beams are referred to as Lommel modes. Explicit analytical relations for the angular spectrum of plane waves and orbital angular momentum of the Lommel beams have been derived. The even (n=2p) and odd (n=2p+1) Lommel modes are mutually orthogonal, as are the Lommel modes characterized by different projections of the wave vector on the optical axis. At a definite parameter, the Lommel modes change to conventional Bessel beams. Asymmetry of the Lommel modes depends on a complex parameter с, with its modulus in the polar notation defining the intensity pattern in the beam‧s cross-section and the argument defining the angle of rotation of the intensity pattern about the optical axis. If the parameter с is real or purely imaginary, the transverse intensity component of the Lommel modes is specularly symmetric about the Cartesian coordinate axes. Besides, with the modulus of the с parameter increasing from 0 to 1, the orbital angular momentum of the Lommel modes increases from a finite value proportional to the topological charge n to infinity. The orbital angular momentum of the Lommel modes undergoes continuous variations, in contrast to its discrete changes in the Bessel modes.

Dual-cavity mode converter for a fundamental mode output in an over-moded relativistic backward-wave oscillator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Jiawei; Huang, Wenhua; Science and Technology on High Power Microwave Laboratory, Northwest Institute of Nuclear Technology, Xi'an 710024

2015-03-16

A dual-cavity TM{sub 02}–TM{sub 01} mode converter is designed for a dual-mode operation over-moded relativistic backward-wave oscillator. With the converter, the fundamental mode output is achieved. Particle-in-cell simulation shows that the efficiency of beam-wave conversion was over 46% and a pureTM{sub 01} mode output was obtained. Effects of end reflection provided by the mode converter were studied. Adequate TM{sub 01} mode feedback provided by the converter enhances conversion efficiency. The distance between the mode converter and extraction cavity critically affect the generation of microwaves depending on the reflection phase of TM{sub 01} mode feedback.

Abnormal brain activation in neurofibromatosis type 1: a link between visual processing and the default mode network.

PubMed

Violante, Inês R; Ribeiro, Maria J; Cunha, Gil; Bernardino, Inês; Duarte, João V; Ramos, Fabiana; Saraiva, Jorge; Silva, Eduardo; Castelo-Branco, Miguel

2012-01-01

Neurofibromatosis type 1 (NF1) is one of the most common single gene disorders affecting the human nervous system with a high incidence of cognitive deficits, particularly visuospatial. Nevertheless, neurophysiological alterations in low-level visual processing that could be relevant to explain the cognitive phenotype are poorly understood. Here we used functional magnetic resonance imaging (fMRI) to study early cortical visual pathways in children and adults with NF1. We employed two distinct stimulus types differing in contrast and spatial and temporal frequencies to evoke relatively different activation of the magnocellular (M) and parvocellular (P) pathways. Hemodynamic responses were investigated in retinotopically-defined regions V1, V2 and V3 and then over the acquired cortical volume. Relative to matched control subjects, patients with NF1 showed deficient activation of the low-level visual cortex to both stimulus types. Importantly, this finding was observed for children and adults with NF1, indicating that low-level visual processing deficits do not ameliorate with age. Moreover, only during M-biased stimulation patients with NF1 failed to deactivate or even activated anterior and posterior midline regions of the default mode network. The observation that the magnocellular visual pathway is impaired in NF1 in early visual processing and is specifically associated with a deficient deactivation of the default mode network may provide a neural explanation for high-order cognitive deficits present in NF1, particularly visuospatial and attentional. A link between magnocellular and default mode network processing may generalize to neuropsychiatric disorders where such deficits have been separately identified.

Time-resolved infrared fluorescence from 2ν 1 and 2ν 8 modes of CF 2Cl 2 excited by a CO 2 laser

NASA Astrophysics Data System (ADS)

Vatsa, R. K.; Kumar, Awadhesh; Naik, P. D.; Rama Rao, K. V. S.; Mittal, J. P.

1993-04-01

Infrared fluorescence has been observed from the overtones and combination bands of ν 1 and ν 8 on pumping either of these modes of CF 2Cl 2 by a CO 2 laser. Excitation of the ν 8 mode gives fluorescence from 2ν 1/(ν 1 + ν 6) and 2ν 8 modes at 4.6 and 5.4 μm, respectively. The intensity of 4.6 μm fluorescence showed a quadratic dependence on the pressure of CF 2Cl 2. A decay rate constant of (2.76±0.55)×10 4 s -1 Torr -1 was obtained for this emission band and it has been assigned to intermode energy outflow from the ν 1 and ν 6 modes. The possible pathways of populating the ν 1 and ν 6 modes are discussed.

Resonant tunnelling diode oscillator as an alternative LO for SIS receiver applications

NASA Technical Reports Server (NTRS)

Blundell, R.; Papa, D. C.; Brown, E. R.; Parker, C. D.

1993-01-01

The resonant tunnelling diode (RTD) oscillator has been demonstrated for the first time as a local oscillator (LO) in a heterodyne receiver. Noise measurements made on a sensitive 200 GHz superconductor-insulator-superconductor receiver using both a multiplied Gunn diode and an RTD oscillator as the LO revealed no difference in receiver noise as a function of oscillator type.

Analyses and tests of the B-1 aircraft structural mode control system

NASA Technical Reports Server (NTRS)

Wykes, J. H.; Byar, T. R.; Macmiller, C. J.; Greek, D. C.

1980-01-01

Analyses and flight tests of the B-1 structural mode control system (SMCS) are presented. Improvements in the total dynamic response of a flexible aircraft and the benefits to ride qualities, handling qualities, crew efficiency, and reduced dynamic loads on the primary structures, were investigated. The effectiveness and the performance of the SMCS, which uses small aerodynamic surfaces at the vehicle nose to provide damping to the structural modes, were evaluated.

Two modes of polyamine block regulating the cardiac inward rectifier K+ current IK1 as revealed by a study of the Kir2.1 channel expressed in a human cell line

PubMed Central

Ishihara, Keiko; Ehara, Tsuguhisa

2004-01-01

The strong inward rectifier K+ current, IK1, shows significant outward current amplitude in the voltage range near the reversal potential and thereby causes rapid repolarization at the final phase of cardiac action potentials. However, the mechanism that generates the outward IK1 is not well understood. We recorded currents from the inside-out patches of HEK 293T cells that express the strong inward rectifier K+ channel Kir2.1 and studied the blockage of the currents caused by cytoplasmic polyamines, namely, spermine and spermidine. The outward current–voltage (I–V) relationships of Kir2.1, obtained with 5–10μm spermine or 10–100μm spermidine, were similar to the steady-state outward I–V relationship of IK1, showing a peak at a level that is ∼20mV more positive than the reversal potential, with a negative slope at more positive voltages. The relationships exhibited a plateau or a double-hump shape with 1μm spermine/spermidine or 0.1μm spermine, respectively. In the chord conductance–voltage relationships, there were extra conductances in the positive voltage range, which could not be described by the Boltzmann relations fitting the major part of the relationships. The extra conductances, which generated most of the outward currents in the presence of 5–10μm spermine or 10–100μm spermidine, were quantitatively explained by a model that considered two populations of Kir2.1 channels, which were blocked by polyamines in either a high-affinity mode (Mode 1 channel) or a low-affinity mode (Mode 2 channel). Analysis of the inward tail currents following test pulses indicated that the relief from the spermine block of Kir2.1 consisted of an exponential component and a virtually instantaneous component. The fractions of the two components nearly agreed with the fractions of the blockages in Mode 1 and Mode 2 calculated by the model. The estimated proportion of Mode 1 channels to total channels was 0.9 with 0.1–10μm spermine, 0.75 with 1–100�

Low-bending loss and single-mode operation in few-mode optical fiber

NASA Astrophysics Data System (ADS)

Yin, Ping; Wang, Hua; Chen, Ming-Yang; Wei, Jin; Cai, Zhi-Min; Li, Lu-Ming; Yang, Ji-Hai; Zhu, Yuan-Feng

2016-10-01

The technique of eliminating the higher-order modes in a few-mode optical fiber is proposed. The fiber is designed with a group of defect modes in the cladding. The higher-order modes in the fiber can be eliminated by bending the fiber to induce strong coupling between the defect modes and the higher-order modes. Numerical simulation shows the bending losses of the LP01 mode are lower than 1.5×10-4 dB/turn for the wavelength shorter than 1.625 μm. The proposed fiber can be bent multiple turns at small bending radius which are preferable for FTTH related applications.

Keystone Life Orientation (LO) Teachers: Implications for Educational, Social, and Cultural Contexts

ERIC Educational Resources Information Center

Pillay, Jace

2012-01-01

The aim of this study was to identify and describe skills, characteristics and support networks needed by keystone Life Orientation (LO) teachers in six Gauteng schools. In this study "keystone" refers to LO teachers who make a positive impact in their schools. A qualitative research design was used to collect data through interviews,…

High resolution spectroscopy of jet cooled phenyl radical: The ν1 and ν2 a1 symmetry C-H stretching modes

NASA Astrophysics Data System (ADS)

Chang, Chih-Hsuan; Nesbitt, David J.

2016-07-01

A series of CH stretch modes in phenyl radical (C6H5) has been investigated via high resolution infrared spectroscopy at sub-Doppler resolution (˜60 MHz) in a supersonic discharge slit jet expansion. Two fundamental vibrations of a1 symmetry, ν1 and ν2, are observed and rotationally analyzed for the first time, corresponding to in-phase and out-of-phase symmetric CH stretch excitation at the ortho/meta/para and ortho/para C atoms with respect to the radical center. The ν1 and ν2 band origins are determined to be 3073.968 50(8) cm-1 and 3062.264 80(7) cm-1, respectively, which both agree within 5 cm-1 with theoretical anharmonic scaling predictions based on density functional B3LYP/6-311g++(3df,3dp) calculations. Integrated band strengths for each of the CH stretch bands are analyzed, with the relative intensities agreeing remarkably well with theoretical predictions. Frequency comparison with previous low resolution Ar-matrix spectroscopy [A. V. Friderichsen et al., J. Am. Chem. Soc. 123, 1977 (2001)] reveals a nearly uniform Δν ≈ + 10-12 cm-1 blue shift between gas phase and Ar matrix values for ν1 and ν2. This differs substantially from the much smaller red shift (Δν ≈ - 1 cm-1) reported for the ν19 mode, and suggests a simple physical model in terms of vibrational mode symmetry and crowding due to the matrix environment. Finally, the infrared phenyl spectra are well described by a simple asymmetric rigid rotor Hamiltonian and show no evidence for spectral congestion due to intramolecular vibrational coupling, which bodes well for high resolution studies of other ring radicals and polycyclic aromatic hydrocarbons. In summary, the combination of slit jet discharge methods with high resolution infrared lasers enables spectroscopic investigation of even highly reactive combustion and interstellar radical intermediates under gas phase, jet-cooled (Trot ≈ 11 K) conditions.

Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meyers, Marvin J.; Pelc, Matthew; Kamtekar, Satwik

2010-08-11

The work described herein demonstrates the utility of structure-based drug design (SBDD) in shifting the binding mode of an HTS hit from a DFG-in to a DFG-out binding mode resulting in a class of novel potent CSF-1R kinase inhibitors suitable for lead development.

Suppression of an acoustic mode by an elastic mode of a liquid-filled spherical shell resonator.

PubMed

Lonzaga, Joel B; Raymond, Jason L; Mobley, Joel; Gaitan, D Felipe

2011-02-01

The purpose of this paper is to report on the suppression of an approximately radial (radially symmetric) acoustic mode by an elastic mode of a water-filled, spherical shell resonator. The resonator, which has a 1-in. wall thickness and a 9.5-in. outer diameter, was externally driven by a small transducer bolted to the external wall. Experiments showed that for the range of drive frequencies (19.7-20.6 kHz) and sound speeds in water (1520-1570 m/s) considered in this paper, a nonradial (radially nonsymmetric) mode was also excited, in addition to the radial mode. Furthermore, as the sound speed in the liquid was changed, the resonance frequency of the nonradial mode crossed with that of the radial one and the amplitude of the latter was greatly reduced near the crossing point. The crossing of the eigenfrequency curves of these two modes was also predicted theoretically. Further calculations demonstrated that while the radial mode is an acoustic one associated with the interior fluid, the nonradial mode is an elastic one associated with the shell. Thus, the suppression of the radial acoustic mode is apparently caused by the overlapping with the nonradial elastic mode near the crossing point.

Scanning thin-sheet laser imaging microscopy (sTSLIM) with structured illumination and HiLo background rejection.

PubMed Central

Schröter, Tobias J.; Johnson, Shane B.; John, Kerstin; Santi, Peter A.

2011-01-01

We report replacement of one side of a static illumination, dual sided, thin-sheet laser imaging microscope (TSLIM) with an intensity modulated laser scanner in order to implement structured illumination (SI) and HiLo image demodulation techniques for background rejection. The new system is equipped with one static and one scanned light-sheet and is called a scanning thin-sheet laser imaging microscope (sTSLIM). It is an optimized version of a light-sheet fluorescent microscope that is designed to image large specimens (<15 mm in diameter). In this paper we describe the hardware and software modifications to TSLIM that allow for static and uniform light-sheet illumination with SI and HiLo image demodulation. The static light-sheet has a thickness of 3.2 µm; whereas, the scanned side has a light-sheet thickness of 4.2 µm. The scanned side images specimens with subcellular resolution (<1 µm lateral and <4 µm axial resolution) with a size up to 15 mm. SI and HiLo produce superior contrast compared to both the uniform static and scanned light-sheets. HiLo contrast was greater than SI and is faster and more robust than SI because as it produces images in two-thirds of the time and exhibits fewer intensity streaking artifacts. PMID:22254177

Scaling Fiber Lasers to Large Mode Area: An Investigation of Passive Mode-Locking Using a Multi-Mode Fiber

PubMed Central

Ding, Edwin; Lefrancois, Simon; Kutz, Jose Nathan; Wise, Frank W.

2011-01-01

The mode-locking of dissipative soliton fiber lasers using large mode area fiber supporting multiple transverse modes is studied experimentally and theoretically. The averaged mode-locking dynamics in a multi-mode fiber are studied using a distributed model. The co-propagation of multiple transverse modes is governed by a system of coupled Ginzburg–Landau equations. Simulations show that stable and robust mode-locked pulses can be produced. However, the mode-locking can be destabilized by excessive higher-order mode content. Experiments using large core step-index fiber, photonic crystal fiber, and chirally-coupled core fiber show that mode-locking can be significantly disturbed in the presence of higher-order modes, resulting in lower maximum single-pulse energies. In practice, spatial mode content must be carefully controlled to achieve full pulse energy scaling. This paper demonstrates that mode-locking performance is very sensitive to the presence of multiple waveguide modes when compared to systems such as amplifiers and continuous-wave lasers. PMID:21731106

Scaling Fiber Lasers to Large Mode Area: An Investigation of Passive Mode-Locking Using a Multi-Mode Fiber.

PubMed

Ding, Edwin; Lefrancois, Simon; Kutz, Jose Nathan; Wise, Frank W

2011-01-01

The mode-locking of dissipative soliton fiber lasers using large mode area fiber supporting multiple transverse modes is studied experimentally and theoretically. The averaged mode-locking dynamics in a multi-mode fiber are studied using a distributed model. The co-propagation of multiple transverse modes is governed by a system of coupled Ginzburg-Landau equations. Simulations show that stable and robust mode-locked pulses can be produced. However, the mode-locking can be destabilized by excessive higher-order mode content. Experiments using large core step-index fiber, photonic crystal fiber, and chirally-coupled core fiber show that mode-locking can be significantly disturbed in the presence of higher-order modes, resulting in lower maximum single-pulse energies. In practice, spatial mode content must be carefully controlled to achieve full pulse energy scaling. This paper demonstrates that mode-locking performance is very sensitive to the presence of multiple waveguide modes when compared to systems such as amplifiers and continuous-wave lasers.

Self-force via m-mode regularization and 2+1D evolution: Foundations and a scalar-field implementation on Schwarzschild spacetime

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dolan, Sam R.; Barack, Leor

2011-01-15

To model the radiative evolution of extreme mass-ratio binary inspirals (a key target of the LISA mission), the community needs efficient methods for computation of the gravitational self-force (SF) on the Kerr spacetime. Here we further develop a practical 'm-mode regularization' scheme for SF calculations, and give the details of a first implementation. The key steps in the method are (i) removal of a singular part of the perturbation field with a suitable 'puncture' to leave a sufficiently regular residual within a finite worldtube surrounding the particle's worldline, (ii) decomposition in azimuthal (m) modes, (iii) numerical evolution of the mmore » modes in 2+1D with a finite-difference scheme, and (iv) reconstruction of the SF from the mode sum. The method relies on a judicious choice of puncture, based on the Detweiler-Whiting decomposition. We give a working definition for the ''order'' of the puncture, and show how it determines the convergence rate of the m-mode sum. The dissipative piece of the SF displays an exponentially convergent mode sum, while the m-mode sum for the conservative piece converges with a power law. In the latter case, the individual modal contributions fall off at large m as m{sup -n} for even n and as m{sup -n+1} for odd n, where n is the puncture order. We describe an m-mode implementation with a 4th-order puncture to compute the scalar-field SF along circular geodesics on Schwarzschild. In a forthcoming companion paper we extend the calculation to the Kerr spacetime.« less

An inductorless multi-mode RF front end for GNSS receiver in 55 nm CMOS

NASA Astrophysics Data System (ADS)

Yanbin, Luo; Chengyan, Ma; Yebing, Gan; Min, Qian; Tianchun, Ye

2015-10-01

An inductorless multi-mode RF front end for a global navigation satellite system (GNSS) receiver is presented. Unlike the traditional topology of a low noise amplifier (LNA), the inductorless current-mode noise-canceling LNA is applied in this design. The high-impedance-input radio frequency amplifier (RFA) further amplifies the GNSS signals and changes the single-end signal path into fully differential. The passive mixer down-converts the signals to the intermediate frequency (IF) band and conveys the signals to the analogue blocks. The local oscillator (LO) buffer divides the output frequency of the voltage controlled oscillator (VCO) and generates 25%-duty-cycle quadrature square waves to drive the mixer. Our measurement results display that the implemented RF front end achieves good overall performance while consuming only 6.7 mA from 1.2 V supply. The input return loss is better than -26 dB and the ultra low noise figure of 1.43 dB leads to high sensitivity of the GNSS receiver. The input 1 dB compression point is -43 dBm at the high gain of 48 dB. The designed circuit is fabricated in 55 nm CMOS technology and the die area, which is much smaller than traditional circuit, is around 220 × 280 μm2.

MuLoG, or How to Apply Gaussian Denoisers to Multi-Channel SAR Speckle Reduction?

PubMed

Deledalle, Charles-Alban; Denis, Loic; Tabti, Sonia; Tupin, Florence

2017-09-01

Speckle reduction is a longstanding topic in synthetic aperture radar (SAR) imaging. Since most current and planned SAR imaging satellites operate in polarimetric, interferometric, or tomographic modes, SAR images are multi-channel and speckle reduction techniques must jointly process all channels to recover polarimetric and interferometric information. The distinctive nature of SAR signal (complex-valued, corrupted by multiplicative fluctuations) calls for the development of specialized methods for speckle reduction. Image denoising is a very active topic in image processing with a wide variety of approaches and many denoising algorithms available, almost always designed for additive Gaussian noise suppression. This paper proposes a general scheme, called MuLoG (MUlti-channel LOgarithm with Gaussian denoising), to include such Gaussian denoisers within a multi-channel SAR speckle reduction technique. A new family of speckle reduction algorithms can thus be obtained, benefiting from the ongoing progress in Gaussian denoising, and offering several speckle reduction results often displaying method-specific artifacts that can be dismissed by comparison between results.

A double B1-mode 4-layer laminated piezoelectric linear motor.

PubMed

Li, Xiaotian; Chen, Zhijiang; Dong, Shuxiang

2012-12-01

We report a miniature piezoelectric ultrasonic linear motor that is made of four Pb(Zr,Ti)O(3) (PZT) piezoelectric ceramic layers for low-voltage work. The 4-layer piezoelectric laminate works in two orthogonal first-bending modes for producing elliptical oscillations, which are then used to drive a contacting slider into continuous linear motion. Experimental results show that the miniature linear motor (size: 4 × 4 × 12 mm, weight: 1.7 g) can generate a large driving force of 0.48 N and a linear motion speed of up to 160 mm/s, using a 40 V(pp)/mm voltage drive at its resonance frequency of 64.5 kHz. The maximum efficiency of the linear motor is 30%.

Performance Evaluation of LoRa Considering Scenario Conditions.

PubMed

Sanchez-Iborra, Ramon; Sanchez-Gomez, Jesus; Ballesta-Viñas, Juan; Cano, Maria-Dolores; Skarmeta, Antonio F

2018-03-03

New verticals within the Internet of Things (IoT) paradigm such as smart cities, smart farming, or goods monitoring, among many others, are demanding strong requirements to the Radio Access Network (RAN) in terms of coverage, end-node's power consumption, and scalability. The technologies employed so far to provide IoT scenarios with connectivity, e.g., wireless sensor network and cellular technologies, are not able to simultaneously cope with these three requirements. Thus, a novel solution known as Low Power - Wide Area Network (LP-WAN) has emerged as a promising alternative to provide with low-cost and low-power-consumption connectivity to end-nodes spread in a wide area. Concretely, the Long-Range Wide Area Network (LoRaWAN) technology is one of the LP-WAN platforms that is receiving greater attention from both the industry and the academia. For that reason, in this work, a comprehensive performance evaluation of LoRaWAN under different environmental conditions is presented. The results are obtained from three real scenarios, namely, urban, suburban, and rural, considering both dynamic and static conditions, hence a discussion about the most proper LoRaWAN physical-layer configuration for each scenario is provided. Besides, a theoretical coverage study is also conducted by the use of a radio planning tool considering topographic maps and a precise propagation model. From the attained results, it can be concluded that it is necessary to evaluate the propagation conditions of the deployment scenario prior to the system implantation in order to reach a compromise between the robustness of the network and the transmission data-rate.

Pressure-induced increase of exciton-LO-phonon coupling in a ZnCdSe/ZnSe quantum well

NASA Astrophysics Data System (ADS)

Guo, Z. Z.; Liang, X. X.; Ban, S. L.

2003-07-01

The possibility of pressure-induced increase of exciton-LO-phonon coupling in ZnCdSe/ZnSe quantum wells is studied. The ground state binding energies of the heavy hole excitons are calculated using a variational method with consideration of the electron-phonon interaction and the pressure dependence of the parameters. The results show that for quantum wells with intermediate well width, the exciton binding energy and the LO-phonon energy may coincide in the course of pressure increasing, resulting in the increase of exciton-LO-phonon coupling. It is also found that among the pressure-dependent parameters, the influence of the lattice constant is the most important one. The changes of both the effective masses and the dielectric constants have obvious effects on the exciton binding energy, but their influences are counterbalanced.

Differential Higgs production at N3LO beyond threshold

NASA Astrophysics Data System (ADS)

Dulat, Falko; Mistlberger, Bernhard; Pelloni, Andrea

2018-01-01

We present several key steps towards the computation of differential Higgs boson cross sections at N3LO in perturbative QCD. Specifically, we work in the framework of Higgs-differential cross sections that allows to compute precise predictions for realistic LHC observables. We demonstrate how to perform an expansion of the analytic N3LO coefficient functions around the production threshold of the Higgs boson. Our framework allows us to compute to arbitrarily high order in the threshold expansion and we explicitly obtain the first two expansion coefficients in analytic form. Furthermore, we assess the phenomenological viability of threshold expansions for differential distributions. We find that while a few terms in the threshold expansion are sufficient to approximate the exact rapidity distribution well, transverse momentum distributions require a signficantly higher number of terms in the expansion to be adequately described. We find that to improve state of the art predictions for the rapidity distribution beyond NNLO even more sub-leading terms in the threshold expansion than presented in this article are required. In addition, we report on an interesting obstacle for the computation of N3LO corrections with LHAPDF parton distribution functions and our solution. We provide files containing the analytic expressions for the partonic cross sections as supplementary material attached to this paper.

LoFEx - A local framework for calculating excitation energies: Illustrations using RI-CC2 linear response theory.

PubMed

Baudin, Pablo; Kristensen, Kasper

2016-06-14

We present a local framework for the calculation of coupled cluster excitation energies of large molecules (LoFEx). The method utilizes time-dependent Hartree-Fock information about the transitions of interest through the concept of natural transition orbitals (NTOs). The NTOs are used in combination with localized occupied and virtual Hartree-Fock orbitals to generate a reduced excitation orbital space (XOS) specific to each transition where a standard coupled cluster calculation is carried out. Each XOS is optimized to ensure that the excitation energies are determined to a predefined precision. We apply LoFEx in combination with the RI-CC2 model to calculate the lowest excitation energies of a set of medium-sized organic molecules. The results demonstrate the black-box nature of the LoFEx approach and show that significant computational savings can be gained without affecting the accuracy of CC2 excitation energies.

Mode control in a high-gain relativistic klystron amplifier

NASA Astrophysics Data System (ADS)

Li, Zheng-Hong; Zhang, Hong; Ju, Bing-Quan; Su, Chang; Wu, Yang

2010-05-01

Middle cavities between the input and output cavity can be used to decrease the required input RF power for the relativistic klystron amplifier. Meanwhile higher modes, which affect the working mode, are also easy to excite in a device with more middle cavities. In order for the positive feedback process for higher modes to be excited, a special measure is taken to increase the threshold current for such modes. Higher modes' excitation will be avoided when the threshold current is significantly larger than the beam current. So a high-gain S-band relativistic klystron amplifier is designed for the beam of current 5 kA and beam voltage 600 kV. Particle in cell simulations show that the gain is 1.6 × 105 with the input RF power of 6.8 kW, and that the output RF power reaches 1.1 GW.

Statistical analysis of m/ n = 2/1 locked and quasi-stationary modes with rotating precursors at DIII-D

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sweeney, Ryan Myles; Choi, W.; La Haye, R. J.

A database has been developed to study the evolution, the nonlinear effects on equilibria, and the disruptivity of locked and quasi-stationary modes with poloidal and toroidal mode numbers m = 2 and n = 1 at DIII-D. The analysis of 22500 discharges shows that more than 18% of disruptions are due to locked or quasi-stationary modes with rotating precursors (not including born locked modes). A parameter formulated by the plasma internal inductance l i divided by the safety factor at 95% of the poloidal flux, q 95, is found to exhibit predictive capability over whether a locked mode will cause a disruption or not, and does so up to hundreds of milliseconds before the disruption. Within 20 ms of the disruption, the shortest distance between the island separatrix and the unperturbed last closed flux surface, referred to as d edge, performs comparably tomore » $${{l}_{i}}/{{q}_{95}}$$ in its ability to discriminate disruptive locked modes. Out of all parameters considered, d edge also correlates best with the duration of the locked mode. Disruptivity following a m/n = 2/1 locked mode as a function of the normalized beta, $${{\\beta}_{\\text{N}}}$$ , is observed to peak at an intermediate value, and decrease for high values. The decrease is attributed to the correlation between $${{\\beta}_{\\text{N}}}$$ and q 95 in the DIII-D operational space. Within 50 ms of a locked mode disruption, average behavior includes exponential growth of the n = 1 perturbed field, which might be due to the 2/1 locked mode. Surprisingly, even assuming the aforementioned 2/1 growth, disruptivity following a locked mode shows little dependence on island width up to 20 ms before the disruption. Separately, greater deceleration of the rotating precursor is observed when the wall torque is large. At locking, modes are often observed to align at a particular phase, which is likely related to a residual error field. Timescales associated with the mode evolution are also studied and dictate the

Statistical analysis of m/ n = 2/1 locked and quasi-stationary modes with rotating precursors at DIII-D

DOE PAGES

Sweeney, Ryan Myles; Choi, W.; La Haye, R. J.; ...

2016-11-01

A database has been developed to study the evolution, the nonlinear effects on equilibria, and the disruptivity of locked and quasi-stationary modes with poloidal and toroidal mode numbers m = 2 and n = 1 at DIII-D. The analysis of 22500 discharges shows that more than 18% of disruptions are due to locked or quasi-stationary modes with rotating precursors (not including born locked modes). A parameter formulated by the plasma internal inductance l i divided by the safety factor at 95% of the poloidal flux, q 95, is found to exhibit predictive capability over whether a locked mode will cause a disruption or not, and does so up to hundreds of milliseconds before the disruption. Within 20 ms of the disruption, the shortest distance between the island separatrix and the unperturbed last closed flux surface, referred to as d edge, performs comparably tomore » $${{l}_{i}}/{{q}_{95}}$$ in its ability to discriminate disruptive locked modes. Out of all parameters considered, d edge also correlates best with the duration of the locked mode. Disruptivity following a m/n = 2/1 locked mode as a function of the normalized beta, $${{\\beta}_{\\text{N}}}$$ , is observed to peak at an intermediate value, and decrease for high values. The decrease is attributed to the correlation between $${{\\beta}_{\\text{N}}}$$ and q 95 in the DIII-D operational space. Within 50 ms of a locked mode disruption, average behavior includes exponential growth of the n = 1 perturbed field, which might be due to the 2/1 locked mode. Surprisingly, even assuming the aforementioned 2/1 growth, disruptivity following a locked mode shows little dependence on island width up to 20 ms before the disruption. Separately, greater deceleration of the rotating precursor is observed when the wall torque is large. At locking, modes are often observed to align at a particular phase, which is likely related to a residual error field. Timescales associated with the mode evolution are also studied and dictate the

Passive mode lockers for lasers generating at a wavelength of 1.06 micron

NASA Astrophysics Data System (ADS)

Mikhailov, V. P.; Demchuk, M. I.; Lugovskii, A. P.; Sosnovskii, G. M.; Iumashev, K. V.

1983-04-01

New polymethine dyes that can be used for the passive mode locking of lasers generating at 1.06 micron are investigated using YAG:Nd as the active element. The effect of introducing various substituents into the heterocyclic nuclei of the end groups of polymethine dyes is discussed. It is shown that substituents generally increase the energy of the ultrashort pulse while also increasing its length.

Collective modes of a two-dimensional spin-1/2 Fermi gas in a harmonic trap

NASA Astrophysics Data System (ADS)

Baur, Stefan K.; Vogt, Enrico; Köhl, Michael; Bruun, Georg M.

2013-04-01

We derive analytical expressions for the frequency and damping of the lowest collective modes of a two-dimensional Fermi gas using kinetic theory. For strong coupling, we furthermore show that pairing correlations overcompensate the effects of Pauli blocking on the collision rate for a large range of temperatures, resulting in a rate which is larger than that of a classical gas. Our results agree well with experimental data, and they recover the observed crossover from collisionless to hydrodynamic behavior with increasing coupling for the quadruple mode. Finally, we show that a trap anisotropy within the experimental bounds results in a damping of the breathing mode which is comparable to what is observed, even for a scale-invariant system.

Effect of Pressure Anisotropy on the m = 1 Small Wavelength Modes in Z-Pinches

NASA Astrophysics Data System (ADS)

Faghihi, M.

1987-05-01

A generalization of Freidberg's perpendicular MHD model is used to investigate the effect of pressure anisotropy on the small wavelength internal kink (m = 1) mode instability in a Z-Pinch. A normal mode analysis of perturbed motion of an incompressible, collisionless and cylindrical plasma is performed. The stability criterion is (rΣB2)' <= 0, where Σ = 1 - (P|| - P⊥)/B2. It cannot be fulfilled without violation of the fire hose stability condition Σ >= 0.

The LoTrach system: its role in the prevention of ventilator-associated pneumonia.

PubMed

Fletcher, Andrew J W; Ruffell, Alison J; Young, Peter J

2008-01-01

To discuss the development of the LoTrach system in light of current evidence around the prevention of ventilator-associated pneumonia (VAP) and its practical application in the intensive care setting. VAP causes substantial morbidity and mortality in ventilated patients in the Intensive Care Unit (ICU), increases length of stay in ICU and is extremely costly. Strategies are needed to reduce the risk of VAP. We examine the need for an endotracheal tube (ETT) specifically designed for the critically-ill patient, the development of the LoTrach system from conception to production, and the role of the various components of the system in preventing VAP. Early issues in implementing this revolutionary equipment into ICU are explored and three case studies highlight advantages of this system. The LoTrach system has been designed to facilitate the provision of a number of evidence-based interventions that have been shown to reduce VAP. Pulmonary aspiration is ubiquitous with conventional cuffs but prevented by the cuff of the LoTrach system when held at a constant and safe pressure against the tracheal wall with a cuff pressure controller. Other aspects incorporated in the ETT are aimed at clearing the secretions from the subglottic space, preventing tube occlusion and accidental extubation, and avoiding damage to the airway. In this way the LoTrach system employs a multifactorial approach to the prevention of VAP and the cost savings from LoTrach rather than a standard ETT will be considerable because of an average 3 day reduction in ICU length of stay related to this. It thus has the potential to be a very useful tool in the ICU setting in the prevention of VAP.

High Resolution Spectroscopy of 1,2-Difluoroethane in a Molecular Beam: A Case Study of Vibrational Mode-Coupling

DTIC Science & Technology

1992-05-29

Spectroscopy of 1,2- Difluoroethane in a Molecular Beam: A Case Study of Vibrational Mode-Coupling by Steven W. Mork, C. Cameron Miller, and Laura A...and sale; its distribution is unlimited. 92-14657 l9lll l l l , II a HIGH RESOLUTION SPECTROSCOPY OF 1,2- DIFLUOROETHANE IN A MOLECULAR BEAM: A CASE...14853-1301 Abstract The high resolution infrared spectrum of 1,2- difluoroethane (DFE) in a molecular beam has been obtained over the 2978-2996 cm-1

Effect of electrode biasing on m/n  =  2/1 tearing modes in J-TEXT experiments

NASA Astrophysics Data System (ADS)

Liu, Hai; Hu, Qiming; Chen, Zhipeng; Yu, Q.; Zhu, Lizhi; Cheng, Zhifeng; Zhuang, Ge; Chen, Zhongyong

2017-01-01

The effects of electrode biasing (EB) on the m/n  =  2/1 tearing mode have been experimentally studied in J-TEXT tokamak discharges, where m and n are the poloidal and toroidal mode numbers. It is found that for a negative bias voltage, the mode amplitude is reduced, and the mode frequency is increased accompanied by the increased toroidal plasma rotation speed in the counter-I p direction. For a positive bias voltage, the mode frequency is decreased together with the change of the rotation velocity towards the co-I p direction, and the mode amplitude is increased. Statistic results show that the variations in the toroidal rotation speed, the 2/1 mode frequency and its amplitude linearly depend on the bias voltage. The threshold voltages for complete suppression and locking of the mode are found. The experimental results suggest that applied electrode biasing is a possible method for the avoidance of mode locking and disruption.

High confinement mode and edge localized mode characteristics in a near-unity aspect ratio tokamak

DOE PAGES

Thome, Kathreen E.; Bongard, Michael W.; Barr, Jayson L.; ...

2016-04-27

Tokamak experiments at near-unity aspect ratio A ≲ 1.2 offer new insights into the self-organized H-mode plasma confinement regime. In contrast to conventional A ~ 3 plasmas, the L–H power threshold P LH is ~15× higher than scaling predictions, and it is insensitive to magnetic topology, consistent with modeling. Edge localized mode (ELM) instabilities shift to lower toroidal mode numbers as A decreases. Furthermore, these ultralow-A operations enable heretofore inaccessible J edge(R,t) measurements through an ELM that show a complex multimodal collapse and the ejection of a current-carrying filament.

6-Gingerol Inhibits Growth of Colon Cancer Cell LoVo via Induction of G2/M Arrest

PubMed Central

Lin, Ching-Bin; Lin, Chun-Che; Tsay, Gregory J.

2012-01-01

6-Gingerol, a natural component of ginger, has been widely reported to possess antiinflammatory and antitumorigenic activities. Despite its potential efficacy against cancer, the anti-tumor mechanisms of 6-gingerol are complicated and remain sketchy. In the present study, we aimed to investigate the anti-tumor effects of 6-gingerol on colon cancer cells. Our results revealed that 6-gingerol treatment significantly reduced the cell viability of human colon cancer cell, LoVo, in a dose-dependent manner. Further flow cytometric analysis showed that 6-gingerol induced significant G2/M phase arrest and had slight influence on sub-G1 phase in LoVo cells. Therefore, levels of cyclins, cyclin-dependent kinases (CDKs), and their regulatory proteins involved in S-G2/M transition were investigated. Our findings revealed that levels of cyclin A, cyclin B1, and CDK1 were diminished; in contrast, levels of the negative cell cycle regulators p27Kip1 and p21Cip1 were increased in response to 6-gingerol treatment. In addition, 6-gingerol treatment elevated intracellular reactive oxygen species (ROS) and phosphorylation level of p53. These findings indicate that exposure of 6-gingerol may induce intracellular ROS and upregulate p53, p27Kip1, and p21Cip1 levels leading to consequent decrease of CDK1, cyclin A, and cyclin B1 as result of cell cycle arrest in LoVo cells. It would be suggested that 6-gingerol should be beneficial to treatment of colon cancer. PMID:22719783

6-Gingerol Inhibits Growth of Colon Cancer Cell LoVo via Induction of G2/M Arrest.

PubMed

Lin, Ching-Bin; Lin, Chun-Che; Tsay, Gregory J

2012-01-01

6-Gingerol, a natural component of ginger, has been widely reported to possess antiinflammatory and antitumorigenic activities. Despite its potential efficacy against cancer, the anti-tumor mechanisms of 6-gingerol are complicated and remain sketchy. In the present study, we aimed to investigate the anti-tumor effects of 6-gingerol on colon cancer cells. Our results revealed that 6-gingerol treatment significantly reduced the cell viability of human colon cancer cell, LoVo, in a dose-dependent manner. Further flow cytometric analysis showed that 6-gingerol induced significant G2/M phase arrest and had slight influence on sub-G1 phase in LoVo cells. Therefore, levels of cyclins, cyclin-dependent kinases (CDKs), and their regulatory proteins involved in S-G2/M transition were investigated. Our findings revealed that levels of cyclin A, cyclin B1, and CDK1 were diminished; in contrast, levels of the negative cell cycle regulators p27(Kip1) and p21(Cip1) were increased in response to 6-gingerol treatment. In addition, 6-gingerol treatment elevated intracellular reactive oxygen species (ROS) and phosphorylation level of p53. These findings indicate that exposure of 6-gingerol may induce intracellular ROS and upregulate p53, p27(Kip1), and p21(Cip1) levels leading to consequent decrease of CDK1, cyclin A, and cyclin B1 as result of cell cycle arrest in LoVo cells. It would be suggested that 6-gingerol should be beneficial to treatment of colon cancer.

Near elimination of ventricular pacing in SafeR mode compared to DDD modes: a randomized study of 422 patients.

PubMed

Davy, Jean-Marc; Hoffmann, Ellen; Frey, Axel; Jocham, Kurt; Rossi, Stefano; Dupuis, Jean-Marc; Frabetti, Lorenzo; Ducloux, Pascale; Prades, Emmanuel; Jauvert, Gaël

2012-04-01

SafeR performance versus DDD/automatic mode conversion (DDD/AMC) and DDD with a 250-ms atrioventricular (AV) delay (DDD/LD) modes was assessed toward ventricular pacing (Vp) reduction. After a 1-month run-in phase, recipients of dual-chamber pacemakers without persistent AV block and persistent atrial fibrillation (AF) were randomly assigned to SafeR, DDD/AMC, or DDD/LD in a 1:1:1 design. The main endpoint was the percentage of Vp (%Vp) at 2 months and 1 year after randomization, ascertained from device memories. Secondary endpoints include %Vp at 1 year according to pacing indication and 1-year AF incidence based on automatic mode switch device stored episodes. Among 422 randomized patients (73.2±10.6 years, 50% men, sinus node dysfunction 47.4%, paroxysmal AV block 30.3%, bradycardia-tachycardia syndrome 21.8%), 141 were assigned to SafeR versus 146 to DDD/AMC and 135 to DDD/LD modes. Mean %Vp at 2 months was 3.4±12.6% in SafeR versus 33.6±34.7% and 14.0±26.0% in DDD/AMC and DDD/LD modes, respectively (P<0.0001 for both). At 1 year, mean %Vp in SafeR was 4.5±15.3% versus 37.9±34.4% and 16.7±28.0% in DDD/AMC and DDD/LD modes, respectively (P<0.0001 for both). The proportion of patients in whom Vp was completely eliminated was significantly higher in SafeR (69%) versus DDD/AMC (15%) and DDD/LD (45%) modes (P<0.0001 for both), regardless of pacing indication. The absolute risk of developing permanent AF or of remaining in AF for >30% of the time was 5.4% lower in SafeR than in the DDD pacing group (ns). In this selected patient population, SafeR markedly suppressed unnecessary Vp compared with DDD modes. ©2012, The Authors. Journal compilation ©2012 Wiley Periodicals, Inc.

Adiabatically tapered microstructured mode converter for selective excitation of the fundamental mode in a few mode fiber.

PubMed

Taher, Aymen Belhadj; Di Bin, Philippe; Bahloul, Faouzi; Tartaret-Josnière, Etienne; Jossent, Mathieu; Février, Sébastien; Attia, Rabah

2016-01-25

We propose a new technique to selectively excite the fundamental mode in a few mode fiber (FMF). This method of excitation is made from a single mode fiber (SMF) which is inserted facing the FMF into an air-silica microstructured cane before the assembly is adiabatically tapered. We study theoretically and numerically this method by calculating the effective indices of the propagated modes, their amplitudes along the taper and the adiabaticity criteria, showing the ability to achieve an excellent selective excitation of the fundamental mode in the FMF with negligible loss. We experimentally demonstrate that the proposed solution provides a successful mode conversion and allows an almost excellent fundamental mode excitation in the FMF (representing 99.8% of the total power).

Scanning thin-sheet laser imaging microscopy (sTSLIM) with structured illumination and HiLo background rejection.

PubMed

Schröter, Tobias J; Johnson, Shane B; John, Kerstin; Santi, Peter A

2012-01-01

We report replacement of one side of a static illumination, dual sided, thin-sheet laser imaging microscope (TSLIM) with an intensity modulated laser scanner in order to implement structured illumination (SI) and HiLo image demodulation techniques for background rejection. The new system is equipped with one static and one scanned light-sheet and is called a scanning thin-sheet laser imaging microscope (sTSLIM). It is an optimized version of a light-sheet fluorescent microscope that is designed to image large specimens (<15 mm in diameter). In this paper we describe the hardware and software modifications to TSLIM that allow for static and uniform light-sheet illumination with SI and HiLo image demodulation. The static light-sheet has a thickness of 3.2 µm; whereas, the scanned side has a light-sheet thickness of 4.2 µm. The scanned side images specimens with subcellular resolution (<1 µm lateral and <4 µm axial resolution) with a size up to 15 mm. SI and HiLo produce superior contrast compared to both the uniform static and scanned light-sheets. HiLo contrast was greater than SI and is faster and more robust than SI because as it produces images in two-thirds of the time and exhibits fewer intensity streaking artifacts. 2011 Optical Society of America

G‐LoSA: An efficient computational tool for local structure‐centric biological studies and drug design

PubMed Central

2016-01-01

Abstract Molecular recognition by protein mostly occurs in a local region on the protein surface. Thus, an efficient computational method for accurate characterization of protein local structural conservation is necessary to better understand biology and drug design. We present a novel local structure alignment tool, G‐LoSA. G‐LoSA aligns protein local structures in a sequence order independent way and provides a GA‐score, a chemical feature‐based and size‐independent structure similarity score. Our benchmark validation shows the robust performance of G‐LoSA to the local structures of diverse sizes and characteristics, demonstrating its universal applicability to local structure‐centric comparative biology studies. In particular, G‐LoSA is highly effective in detecting conserved local regions on the entire surface of a given protein. In addition, the applications of G‐LoSA to identifying template ligands and predicting ligand and protein binding sites illustrate its strong potential for computer‐aided drug design. We hope that G‐LoSA can be a useful computational method for exploring interesting biological problems through large‐scale comparison of protein local structures and facilitating drug discovery research and development. G‐LoSA is freely available to academic users at http://im.compbio.ku.edu/GLoSA/. PMID:26813336

G-LoSA: An efficient computational tool for local structure-centric biological studies and drug design.

PubMed

Lee, Hui Sun; Im, Wonpil

2016-04-01

Molecular recognition by protein mostly occurs in a local region on the protein surface. Thus, an efficient computational method for accurate characterization of protein local structural conservation is necessary to better understand biology and drug design. We present a novel local structure alignment tool, G-LoSA. G-LoSA aligns protein local structures in a sequence order independent way and provides a GA-score, a chemical feature-based and size-independent structure similarity score. Our benchmark validation shows the robust performance of G-LoSA to the local structures of diverse sizes and characteristics, demonstrating its universal applicability to local structure-centric comparative biology studies. In particular, G-LoSA is highly effective in detecting conserved local regions on the entire surface of a given protein. In addition, the applications of G-LoSA to identifying template ligands and predicting ligand and protein binding sites illustrate its strong potential for computer-aided drug design. We hope that G-LoSA can be a useful computational method for exploring interesting biological problems through large-scale comparison of protein local structures and facilitating drug discovery research and development. G-LoSA is freely available to academic users at http://im.compbio.ku.edu/GLoSA/. © 2016 The Protein Society.

A new description of Earth's wobble modes using Clairaut coordinates: 1. Theory

NASA Astrophysics Data System (ADS)

Rochester, M. G.; Crossley, D. J.; Zhang, Y. L.

2014-09-01

This paper presents a novel mathematical reformulation of the theory of the free wobble/nutation of an axisymmetric reference earth model in hydrostatic equilibrium, using the linear momentum description. The new features of this work consist in the use of (i) Clairaut coordinates (rather than spherical polars), (ii) standard spherical harmonics (rather than generalized spherical surface harmonics), (iii) linear operators (rather than J-square symbols) to represent the effects of rotational and ellipticity coupling between dependent variables of different harmonic degree and (iv) a set of dependent variables all of which are continuous across material boundaries. The resulting infinite system of coupled ordinary differential equations is given explicitly, for an elastic solid mantle and inner core, an inviscid outer core and no magnetic field. The formulation is done to second order in the Earth's ellipticity. To this order it is shown that for wobble modes (in which the lowest harmonic in the displacement field is degree 1 toroidal, with azimuthal order m = ±1), it is sufficient to truncate the chain of coupled displacement fields at the toroidal harmonic of degree 5 in the solid parts of the earth model. In the liquid core, however, the harmonic expansion of displacement can in principle continue to indefinitely high degree at this order of accuracy. The full equations are shown to yield correct results in three simple cases amenable to analytic solution: a general earth model in rigid rotation, the tiltover mode in a homogeneous solid earth model and the tiltover and Chandler periods for an incompressible homogeneous solid earth model. Numerical results, from programmes based on this formulation, are presented in part II of this paper.

High Confinement Mode and Edge Localized Mode Characteristics in a Near-Unity Aspect Ratio Tokamak.

PubMed

Thome, K E; Bongard, M W; Barr, J L; Bodner, G M; Burke, M G; Fonck, R J; Kriete, D M; Perry, J M; Schlossberg, D J

2016-04-29

Tokamak experiments at near-unity aspect ratio A≲1.2 offer new insights into the self-organized H-mode plasma confinement regime. In contrast to conventional A∼3 plasmas, the L-H power threshold P_{LH} is ∼15× higher than scaling predictions, and it is insensitive to magnetic topology, consistent with modeling. Edge localized mode (ELM) instabilities shift to lower toroidal mode numbers as A decreases. These ultralow-A operations enable heretofore inaccessible J_{edge}(R,t) measurements through an ELM that show a complex multimodal collapse and the ejection of a current-carrying filament.

Performance Evaluation of LoRa Considering Scenario Conditions

PubMed Central

Sanchez-Gomez, Jesus; Ballesta-Viñas, Juan

2018-01-01

New verticals within the Internet of Things (IoT) paradigm such as smart cities, smart farming, or goods monitoring, among many others, are demanding strong requirements to the Radio Access Network (RAN) in terms of coverage, end-node’s power consumption, and scalability. The technologies employed so far to provide IoT scenarios with connectivity, e.g., wireless sensor network and cellular technologies, are not able to simultaneously cope with these three requirements. Thus, a novel solution known as Low Power - Wide Area Network (LP-WAN) has emerged as a promising alternative to provide with low-cost and low-power-consumption connectivity to end-nodes spread in a wide area. Concretely, the Long-Range Wide Area Network (LoRaWAN) technology is one of the LP-WAN platforms that is receiving greater attention from both the industry and the academia. For that reason, in this work, a comprehensive performance evaluation of LoRaWAN under different environmental conditions is presented. The results are obtained from three real scenarios, namely, urban, suburban, and rural, considering both dynamic and static conditions, hence a discussion about the most proper LoRaWAN physical-layer configuration for each scenario is provided. Besides, a theoretical coverage study is also conducted by the use of a radio planning tool considering topographic maps and a precise propagation model. From the attained results, it can be concluded that it is necessary to evaluate the propagation conditions of the deployment scenario prior to the system implantation in order to reach a compromise between the robustness of the network and the transmission data-rate. PMID:29510524

Drag reduction by polymers in turbulent channel flows: Energy redistribution between invariant empirical modes.

PubMed

De Angelis, Elisabetta; Casciola, Carlo M; L'vov, Victor S; Piva, Renzo; Procaccia, Itamar

2003-05-01

We address the phenomenon of drag reduction by a dilute polymeric additive to turbulent flows, using direct numerical simulations (DNS) of the FENE-P model of viscoelastic flows. It had been amply demonstrated that these model equations reproduce the phenomenon, but the results of DNS were not analyzed so far with the goal of interpreting the phenomenon. In order to construct a useful framework for the understanding of drag reduction we initiate in this paper an investigation of the most important modes that are sustained in the viscoelastic and Newtonian turbulent flows, respectively. The modes are obtained empirically using the Karhunen-Loéve decomposition, allowing us to compare the most energetic modes in the viscoelastic and Newtonian flows. The main finding of the present study is that the spatial profile of the most energetic modes is hardly changed between the two flows. What changes is the energy associated with these modes, and their relative ordering in the decreasing order from the most energetic to the least. Modes that are highly excited in one flow can be strongly suppressed in the other, and vice versa. This dramatic energy redistribution is an important clue to the mechanism of drag reduction as is proposed in this paper. In particular, there is an enhancement of the energy containing modes in the viscoelastic flow compared to the Newtonian one; drag reduction is seen in the energy containing modes rather than the dissipative modes, as proposed in some previous theories.

Investigation on the oscillation modes in a thermoacoustic Stirling prime mover: mode stability and mode transition

NASA Astrophysics Data System (ADS)

Yu, Z. B.; Li, Q.; Chen, X.; Guo, F. Z.; Xie, X. J.; Wu, J. H.

2003-12-01

The purpose of this paper is to investigate the stability of oscillation modes in a thermoacoustic Stirling prime mover, which is a combination of looped tube and resonator. Two modes, with oscillation frequencies of 76 and 528 Hz, have been observed, stabilities of which are widely different. The stability of the high frequency mode (HFM) is affected by low frequency mode (LFM) strongly. Once the LFM is excited when the HFM is present, the HFM will be gradually slaved and suppressed by the LFM. The details of the transition from HFM to LFM have been described. The two stability curves of the two modes have been measured. Mean pressure Pm is an important control parameter influencing the mode stability in the tested system.

Modified n-level, n - 1-mode Tavis-Cummings model and algebraic Bethe ansatz

NASA Astrophysics Data System (ADS)

Skrypnyk, T.

2018-01-01

Using the quantum group technique we construct a one-parametric family of integrable modifications of the n-level, n-1 mode Tavis-Cummings Hamiltonian possessing an additional Stark-type term. We show that in the ‘quasiclassical’ limit the constructed Hamiltonian transforms into the integrable Hamiltonian of the quantum n-level, n-1 mode Tavis-Cummings model with the equal interaction strengths considered in Skrypnyk (2008 J. Phys. A: Math. Theor. 41 475202, 2009 J. Math. Phys. 50 103523). We diagonalize the constructed ‘modified’ Tavis-Cummings Hamiltonian and its second order integrals of motion using the nested Bethe ansatz.

The PSA−/lo prostate cancer cell population harbors self-renewing long-term tumor-propagating cells that resist castration

PubMed Central

Qin, Jichao; Liu, Xin; Laffin, Brian; Chen, Xin; Choy, Grace; Jeter, Collene; Calhoun-Davis, Tammy; Li, Hangwen; Palapattu, Ganesh S.; Pang, Shen; Lin, Kevin; Huang, Jiaoti; Ivanov, Ivan; Li, Wei; Suraneni, Mahipal V.; Tang, Dean G.

2012-01-01

SUMMARY Prostate cancer (PCa) is heterogeneous and contains both differentiated and undifferentiated tumor cells, but the relative functional contribution of these two cell populations remains unclear. Here we report distinct molecular, cellular, and tumor-propagating properties of PCa cells that express high (PSA+) and low (PSA−/lo) levels of the differentiation marker PSA. PSA−/lo PCa cells are quiescent and refractory to stresses including androgen deprivation, exhibit high clonogenic potential, and possess long-term tumor-propagating capacity. They preferentially express stem cell genes and can undergo asymmetric cell division generating PSA+ cells. Importantly, PSA−/lo PCa cells can initiate robust tumor development and resist androgen ablation in castrated hosts, and harbor highly tumorigenic castration-resistant PCa cells that can be prospectively enriched using ALDH+CD44+α2β1+ phenotype. In contrast, PSA+ PCa cells possess more limited tumor-propagating capacity, undergo symmetric division and are sensitive to castration. Together, our study suggests PSA−/lo cells may represent a critical source of castration-resistant PCa cells. PMID:22560078

A saw-less direct conversion long term evolution receiver with 25% duty-cycle LO in 130 nm CMOS technology

NASA Astrophysics Data System (ADS)

Siyuan, He; Changhong, Zhang; Liang, Tao; Weifeng, Zhang; Longyue, Zeng; Wei, Lü; Haijun, Wu

2013-03-01

A CMOS long-term evolution (LTE) direct convert receiver that eliminates the interstage SAW filter is presented. The receiver consists of a low noise variable gain transconductance amplifier (TCA), a quadrature passive current commutating mixer with a 25% duty-cycle LO, a trans-impedance amplifier (TIA), a 7th-order Chebyshev filter and programmable gain amplifiers (PGAs). A wide dynamic gain range is allocated in the RF and analog parts. A current commutating passive mixer with a 25% duty-cycle LO improves gain, noise, and linearity. An LPF based on a Tow-Thomas biquad suppresses out-of-band interference. Fabricated in a 0.13 μm CMOS process, the receiver chain achieves a 107 dB maximum voltage gain, 2.7 dB DSB NF (from PAD port), -11 dBm IIP3, and > +65 dBm IIP2 after calibration, 96 dB dynamic control range with 1 dB steps, less than 2% error vector magnitude (EVM) from 2.3 to 2.7 GHz. The total receiver (total I Q path) draws 89 mA from a 1.2-V LDO on chip supply.

Propagating annular modes

NASA Astrophysics Data System (ADS)

Sheshadri, A.; Plumb, R. A.

2017-12-01

The leading "annular mode", defined as the dominant EOF of surface pressure or of zonal mean zonal wind variability, appears as a dipolar structure straddling the mean midlatitude jet and thus seems to describe north-south wobbling of the jet latitude. However, extratropical zonal wind anomalies frequently tend to migrate poleward. This behavior can be described by the first two EOFs, the first (AM1) being the dipolar structure, and the second (AM2) having a tripolar structure centered on the mean jet. Taken in isolation, AM1 thus describes a north-south wobbling of the jet position, while AM2 describes a strengthening and narrowing of the jet. However, despite the fact that they are spatially orthogonal, and their corresponding time series temporally orthogonal, AM1 and AM2 are not independent, but show significant lag-correlations which reveal the propagation. The EOFs are not modes of the underlying dynamical system governing the zonal flow evolution. The true modes can be estimated using principal oscillation pattern (POP) analysis. In the troposphere, the leading POPs manifest themselves as a pair of complex conjugate structures with conjugate eigenvalues thus, in reality, constituting a single, complex, mode that describes propagating anomalies. Even though the principal components associated with the two leading EOFs decay at different rates, each decays faster than the true mode. These facts have implications for eddy feedback and the susceptibility of the mode to external perturbations. If one interprets the annular modes as the modes of the system, then simple theory predicts that the response to steady forcing will usually be dominated by AM1 (with the longest time scale). However, such arguments should really be applied to the true modes. Experiments with a simplified GCM show that climate response to perturbations do not necessarily have AM1 structures. Implications of these results for stratosphere-troposphere interactions are explored. The POP

LO2/LH2 propulsion for outer planet orbiter spacecraft

NASA Technical Reports Server (NTRS)

Garrison, P. W.; Sigurdson, K. B.

1983-01-01

Galileo class orbiter missions (750-1500 kg) to the outer planets require a large postinjection delta-V for improved propulsion performance. The present investigation shows that a pump-fed low thrust LO2/LH2 propulsion system can provide a significantly larger net on-orbit mass for a given delta-V than a state-of-the-art earth storable, N2O4/monomethylhydrazine pressure-fed propulsion system. A description is given of a conceptual design for a LO2/LH2 pump-fed propulsion system developed for a Galileo class mission to the outer planets. Attention is given to spacecraft configuration, details regarding the propulsion system, the thermal control of the cryogenic propellants, and aspects of mission performance.

Differential Higgs production at N 3LO beyond threshold

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dulat, Falko; Mistlberger, Bernhard; Pelloni, Andrea

We present several key steps towards the computation of differential Higgs boson cross sections at N 3LO in perturbative QCD. Specifically, we work in the framework of Higgs-differential cross sections that allows to compute precise predictions for realistic LHC observables. We demonstrate how to perform an expansion of the analytic N 3LO coefficient functions around the production threshold of the Higgs boson. Our framework allows us to compute to arbitrarily high order in the threshold expansion and we explicitly obtain the first two expansion coefficients in analytic form. Furthermore, we assess the phenomenological viability of threshold expansions for differential distributions.more » We find that while a few terms in the threshold expansion are sufficient to approximate the exact rapidity distribution well, transverse momentum distributions require a signficantly higher number of terms in the expansion to be adequately described. We find that to improve state of the art predictions for the rapidity distribution beyond NNLO even more sub-leading terms in the threshold expansion than presented in this article are required. In addition, we report on an interesting obstacle for the computation of N 3LO corrections with LHAPDF parton distribution functions and our solution. We provide files containing the analytic expressions for the partonic cross sections as supplementary material attached to this paper.« less

Differential Higgs production at N 3LO beyond threshold

DOE PAGES

Dulat, Falko; Mistlberger, Bernhard; Pelloni, Andrea

2018-01-29

We present several key steps towards the computation of differential Higgs boson cross sections at N 3LO in perturbative QCD. Specifically, we work in the framework of Higgs-differential cross sections that allows to compute precise predictions for realistic LHC observables. We demonstrate how to perform an expansion of the analytic N 3LO coefficient functions around the production threshold of the Higgs boson. Our framework allows us to compute to arbitrarily high order in the threshold expansion and we explicitly obtain the first two expansion coefficients in analytic form. Furthermore, we assess the phenomenological viability of threshold expansions for differential distributions.more » We find that while a few terms in the threshold expansion are sufficient to approximate the exact rapidity distribution well, transverse momentum distributions require a signficantly higher number of terms in the expansion to be adequately described. We find that to improve state of the art predictions for the rapidity distribution beyond NNLO even more sub-leading terms in the threshold expansion than presented in this article are required. In addition, we report on an interesting obstacle for the computation of N 3LO corrections with LHAPDF parton distribution functions and our solution. We provide files containing the analytic expressions for the partonic cross sections as supplementary material attached to this paper.« less

Three dimensional HiLo-based structured illumination for a digital scanned laser sheet microscopy (DSLM) in thick tissue imaging.

PubMed

Bhattacharya, Dipanjan; Singh, Vijay Raj; Zhi, Chen; So, Peter T C; Matsudaira, Paul; Barbastathis, George

2012-12-03

Laser sheet based microscopy has become widely accepted as an effective active illumination method for real time three-dimensional (3D) imaging of biological tissue samples. The light sheet geometry, where the camera is oriented perpendicular to the sheet itself, provides an effective method of eliminating some of the scattered light and minimizing the sample exposure to radiation. However, residual background noise still remains, limiting the contrast and visibility of potentially interesting features in the samples. In this article, we investigate additional structuring of the illumination for improved background rejection, and propose a new technique, "3D HiLo" where we combine two HiLo images processed from orthogonal directions to improve the condition of the 3D reconstruction. We present a comparative study of conventional structured illumination based demodulation methods, namely 3Phase and HiLo with a newly implemented 3D HiLo approach and demonstrate that the latter yields superior signal-to-background ratio in both lateral and axial dimensions, while simultaneously suppressing image processing artifacts.

a Study of Vibrational Mode Coupling in 2-FLUOROETHANOL and 1,2-DIFLUOROETHANE Using High-Resolution Infrared Spectroscopy.

NASA Astrophysics Data System (ADS)

Mork, Steven Wayne

High resolution infrared spectroscopy was used to examine intramolecular vibrational interactions in 2 -fluoroethanol (2FE) and 1,2-difluoroethane (DFE). A high resolution infrared spectrophotometer capable of better than 10 MHz spectral resolution was designed and constructed. The excitation source consists of three lasers: an argon-ion pumped dye laser which pumps a color -center laser. The infrared beam from the color-center laser is used to excite sample molecules which are rotationally and vibrationally cooled in a supersonic molecular beam. Rovibrational excitation of the sample molecules is detected by monitoring the kinetic energy of the molecular beam with a bolometer. The high resolution infrared spectrum of 2FE was collected and analyzed over the 2977-2990 cm^ {-1}^ectral region. This region contains the asymmetric CH stretch on the fluorinated carbon. The spectrum revealed extensive perturbations in the rotational fine structure. Analysis of these perturbations has provided a quantitative measure of selective vibrational mode coupling between the C-H stretch and its many neighboring dark vibrational modes. Interestingly, excitation of the C-H stretch is known to induce a photoisomerization reaction between 2FE's Gg^' and Tt conformers. Implications of the role of mode coupling in the reaction mechanism are also addressed. Similarly, the high resolution infrared spectrum of DFE was collected and analyzed over the 2978-2996 cm ^{-1}^ectral region. This region contains the symmetric combination of asymmetric C-H stretches in DFE. Perturbations in the rotational fine structure indicate vibrational mode coupling to a single dark vibrational state. The dark state is split by approximately 19 cm^{-1} due to tunneling between two identical gauche conformers. The coupling mechanism is largely anharmonic with a minor component of B/C-plane Coriolis coupling. Effects of centrifugal distortion along the molecular A-axis are also observed. The coupled vibrational

Energetic particle modes of q = 1 high-order harmonics in tokamak plasmas with monotonic weak magnetic shear

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ren, Zhen-Zhen; Wang, Feng; Fu, G. Y.

Linear and nonlinear simulations of high-order harmonics q=1 energetic particle modes excited by trapped energetic particles in tokamaks are carried out using kinetic/magnetohydrodynamic hybrid code M3D-K. It is found that with a flat safety factor profile in the core region, the linear growth rate of high-order harmonics (m=n>1) driven by energetic trapped particles can be higher than the m/n=1/1 component. The high m=n>1 modes become more unstable when the pressure of energetic particles becomes higher. Moreover, it is shown that there exist multiple resonant locations satisfying different resonant conditions in the phase space of energetic particles for the high-order harmonicsmore » modes, whereas there is only one precessional resonance for the m/n=1/1 harmonics. The fluid nonlinearity reduces the saturation level of the n=1 component, while it hardly affects those of the high n components, especially the modes with m=n=3,4. The frequency of these modes does not chirp significantly, which is different with the typical fishbone driven by trapped particles. Lastly, in addition, the flattening region of energetic particle distribution due to high-order harmonics excitation is wider than that due to m/n=1/1 component, although the m/n=1/1 component has a higher saturation amplitude.« less

Energetic particle modes of q = 1 high-order harmonics in tokamak plasmas with monotonic weak magnetic shear

DOE PAGES

Ren, Zhen-Zhen; Wang, Feng; Fu, G. Y.; ...

2017-04-24

Linear and nonlinear simulations of high-order harmonics q=1 energetic particle modes excited by trapped energetic particles in tokamaks are carried out using kinetic/magnetohydrodynamic hybrid code M3D-K. It is found that with a flat safety factor profile in the core region, the linear growth rate of high-order harmonics (m=n>1) driven by energetic trapped particles can be higher than the m/n=1/1 component. The high m=n>1 modes become more unstable when the pressure of energetic particles becomes higher. Moreover, it is shown that there exist multiple resonant locations satisfying different resonant conditions in the phase space of energetic particles for the high-order harmonicsmore » modes, whereas there is only one precessional resonance for the m/n=1/1 harmonics. The fluid nonlinearity reduces the saturation level of the n=1 component, while it hardly affects those of the high n components, especially the modes with m=n=3,4. The frequency of these modes does not chirp significantly, which is different with the typical fishbone driven by trapped particles. Lastly, in addition, the flattening region of energetic particle distribution due to high-order harmonics excitation is wider than that due to m/n=1/1 component, although the m/n=1/1 component has a higher saturation amplitude.« less

Single-mode SOA-based 1kHz-linewidth dual-wavelength random fiber laser.

PubMed

Xu, Yanping; Zhang, Liang; Chen, Liang; Bao, Xiaoyi

2017-07-10

Narrow-linewidth multi-wavelength fiber lasers are of significant interests for fiber-optic sensors, spectroscopy, optical communications, and microwave generation. A novel narrow-linewidth dual-wavelength random fiber laser with single-mode operation, based on the semiconductor optical amplifier (SOA) gain, is achieved in this work for the first time, to the best of our knowledge. A simplified theoretical model is established to characterize such kind of random fiber laser. The inhomogeneous gain in SOA mitigates the mode competition significantly and alleviates the laser instability, which are frequently encountered in multi-wavelength fiber lasers with Erbium-doped fiber gain. The enhanced random distributed feedback from a 5km non-uniform fiber provides coherent feedback, acting as mode selection element to ensure single-mode operation with narrow linewidth of ~1kHz. The laser noises are also comprehensively investigated and studied, showing the improvements of the proposed random fiber laser with suppressed intensity and frequency noises.

Estradiol agonists inhibit human LoVo colorectal-cancer cell proliferation and migration through p53.

PubMed

Hsu, Hsi-Hsien; Kuo, Wei-Wen; Ju, Da-Tong; Yeh, Yu-Lan; Tu, Chuan-Chou; Tsai, Ying-Lan; Shen, Chia-Yao; Chang, Sheng-Huang; Chung, Li-Chin; Huang, Chih-Yang

2014-11-28

To investigate the effects of 17β-estradiol via estrogen receptors (ER) or direct administration of ER agonists on human colorectal cancer. LoVo cells were established from the Bioresource Collection and Research Center and cultured in phenol red-free DMEM (Sigma, United States). To investigate the effects of E2 and/or ER selective agonists on cellular proliferation, LoVo colorectal cells were treated with E2 or ER-selective agonists for 24 h and 48 h and subjected to the MTT (Sigma) assay to find the concentration. And investigate the effects of E2 and/or ER selective agonists on cell used western immunoblotting to find out the diversification of signaling pathways. In order to observe motility and migration the wound healing assay and a transwell chamber (Neuro Probe) plate were tased. For a quantitative measure, we counted the number of migrating cells to the wound area post-wounding for 24 h. We further examined the cellular migration-regulating factors urokinase-type plasminogen activator (u-PA), tissue-type plasminogen activator (t-PA) and matrix metalloproteinase (MMP)-9 in human LoVo cells so gelatin zymography that we used and gelatinolytic activity was visualized by Coomassie blue staining. And these results are presented as means ± SE, and statistical comparisons were made using Student's t-test. The structure was first compared with E2 and ER agonists. We then treated the LoVo cells with E2 and ER agonists (10(-8) mol/L) for 24 h and 48 h and subsequently measured the cell viability using MTT assay. Our results showed that treatment with 17β-estradiol and/or ER agonists in human LoVo colorectal cancer cells activated p53 and then up-regulated p21 and p27 protein levels, subsequently inhibiting the downstream target gene, cyclin D1, which regulates cell proliferation. Taken together, our findings demonstrate the anti-tumorigenesis effects of 17β-estradiol and/or ER agonists and suggest that these compounds may prove to be a potential alternative

Improving high resolution retinal image quality using speckle illumination HiLo imaging

PubMed Central

Zhou, Xiaolin; Bedggood, Phillip; Metha, Andrew

2014-01-01

Retinal image quality from flood illumination adaptive optics (AO) ophthalmoscopes is adversely affected by out-of-focus light scatter due to the lack of confocality. This effect is more pronounced in small eyes, such as that of rodents, because the requisite high optical power confers a large dioptric thickness to the retina. A recently-developed structured illumination microscopy (SIM) technique called HiLo imaging has been shown to reduce the effect of out-of-focus light scatter in flood illumination microscopes and produce pseudo-confocal images with significantly improved image quality. In this work, we adopted the HiLo technique to a flood AO ophthalmoscope and performed AO imaging in both (physical) model and live rat eyes. The improvement in image quality from HiLo imaging is shown both qualitatively and quantitatively by using spatial spectral analysis. PMID:25136486

Improving high resolution retinal image quality using speckle illumination HiLo imaging.

PubMed

Zhou, Xiaolin; Bedggood, Phillip; Metha, Andrew

2014-08-01

Retinal image quality from flood illumination adaptive optics (AO) ophthalmoscopes is adversely affected by out-of-focus light scatter due to the lack of confocality. This effect is more pronounced in small eyes, such as that of rodents, because the requisite high optical power confers a large dioptric thickness to the retina. A recently-developed structured illumination microscopy (SIM) technique called HiLo imaging has been shown to reduce the effect of out-of-focus light scatter in flood illumination microscopes and produce pseudo-confocal images with significantly improved image quality. In this work, we adopted the HiLo technique to a flood AO ophthalmoscope and performed AO imaging in both (physical) model and live rat eyes. The improvement in image quality from HiLo imaging is shown both qualitatively and quantitatively by using spatial spectral analysis.

Femtosecond Mode-locked Fiber Laser at 1 μm Via Optical Microfiber Dispersion Management.

PubMed

Wang, Lizhen; Xu, Peizhen; Li, Yuhang; Han, Jize; Guo, Xin; Cui, Yudong; Liu, Xueming; Tong, Limin

2018-03-16

Mode-locked Yb-doped fiber lasers around 1 μm are attractive for high power applications and low noise pulse train generation. Mode-locked fiber lasers working in soliton and stretched-pulse regime outperform others in terms of the laser noise characteristics, mechanical stability and easy maintenance. However, conventional optical fibers always show a normal group velocity dispersion around 1 μm, leading to the inconvenience for necessary dispersion management. Here we show that optical microfibers having a large anomalous dispersion around 1 μm can be integrated into mode-locked Yb-doped fiber lasers with ultralow insertion loss down to -0.06 dB, enabling convenient dispersion management of the laser cavity. Besides, optical microfibers could also be adopted to spectrally broaden and to dechirp the ultrashort pulses outside the laser cavity, giving rise to a pulse duration of about 110 fs. We believe that this demonstration may facilitate all-fiber format high-performance ultrashort pulse generation at 1 μm and may find applications in precision measurements, large-scale facility synchronization and evanescent-field-based optical sensing.

Revealing interaction mode between HIV-1 protease and mannitol analog inhibitor.

PubMed

Yan, Guan-Wen; Chen, Yue; Li, Yixue; Chen, Hai-Feng

2012-06-01

HIV protease is a key enzyme to play a key role in the HIV-1 replication cycle and control the maturation from HIV viruses to an infectious virion. HIV-1 protease has become an important target for anti-HIV-1 drug development. Here, we used molecular dynamics simulation to study the binding mode between mannitol derivatives and HIV-1 protease. The results suggest that the most active compound (M35) has more stable hydrogen bonds and stable native contacts than the less active one (M17). These mannitol derivatives might have similar interaction mode with HIV-1 protease. Then, 3D-QSAR was used to construct quantitative structure-activity models. The cross-validated q(2) values are found as 0.728 and 0.611 for CoMFA and CoMSIA, respectively. And the non-cross-validated r(2) values are 0.973 and 0.950. Nine test set compounds validate the model. The results show that this model possesses better prediction ability than the previous work. This model can be used to design new chemical entities and make quantitative prediction of the bioactivities for HIV-1 protease inhibitors before resorting to in vitro and in vivo experiment. © 2012 John Wiley & Sons A/S.

A Surface Formulation for Characteristic Modes of Material Bodies

DTIC Science & Technology

1974-10-01

42 CHAPTER 3 4: CHARACTERISTIC MODES - A SURFACE FORMULATION 3.1 Theoretical Development The treatment of characteristic modes for perfectly...cgs* i + y mp ein•£ (A6 V; 1 TP At • CA6 I --- 4 1 o#i ajk(X MPcoeo* + umpsin# ) Iim n p-l1 Tp -Ax sin#i + Ay co* ] i (A-7) A4 APPWOIX II fill I vIal

Passive mode locking of a GaSb-based quantum well diode laser emitting at 2.1 μm

DOE Office of Scientific and Technical Information (OSTI.GOV)

Merghem, K.; Aubin, G.; Ramdane, A.

2015-09-14

We demonstrate passive mode locking of a GaSb-based diode laser emitting at 2.1 μm. The active region of the studied device consists in two 10-nm-thick GaInSbAs/GaAlSbAs quantum wells. Passive mode locking has been achieved in a two-section laser with one of the sections used as a saturable absorber. A microwave signal at 20.6 GHz, measured in the electrical circuit of the absorber, corresponds to the fundamental photon round-trip frequency in the laser resonator. The linewidth of this signal as low as ∼10 kHz has been observed at certain operating conditions, indicating low phase noise mode-locked operation.

Goldstone and Higgs modes of photons inside a cavity

NASA Astrophysics Data System (ADS)

Yi-Xiang, Yu; Ye, Jinwu; Liu, Wu-Ming

2013-12-01

Goldstone and Higgs modes have been detected in various condensed matter, cold atom and particle physics experiments. Here, we demonstrate that the two modes can also be observed in optical systems with only a few (artificial) atoms inside a cavity. We establish this connection by studying the U(1)/Z2 Dicke model where N qubits (atoms) coupled to a single photon mode. We determine the Goldstone and Higgs modes inside the super-radiant phase and their corresponding spectral weights by performing both 1/J = 2/N expansion and exact diagonalization (ED) study at a finite N. We find nearly perfect agreements between the results achieved by the two approaches when N gets down even to N = 2. The quantum finite size effects at a few qubits make the two modes quite robust against an effectively small counterrotating wave term. We present a few schemes to reduce the critical coupling strength, so the two modes can be observed in several current available experimental systems by just conventional optical measurements.

Long Wave Atmospheric Noise Model. Phase 1. Volume 2. Mode Parameters

DTIC Science & Technology

1989-04-10

r BY - TO GET TO GET 4 BY 4 - DIVIDE Agstrom 1. 000 000 X E -10 meotrs (ml atmosphere (rormal) . la 2.5 X E +Z ktio 1pascal ( kId ) bar 1.000 000 X E -2...I ’ I I! ’i"+ I .It . , I , 0. 0. I + : 1 0.2, 0.. 3r Re C No rE: High coonductivity pOrn mar*ed wtth 0 for TM modes, A for TE. Figure 56

Curcumin suppresses JNK pathway to attenuate BPA-induced insulin resistance in LO2 cells.

PubMed

Geng, Shanshan; Wang, Shijia; Zhu, Weiwei; Xie, Chunfeng; Li, Xiaoting; Wu, Jieshu; Zhu, Jianyun; Jiang, Ye; Yang, Xue; Li, Yuan; Chen, Yue; Wang, Xiaoqian; Meng, Yu; Zhong, Caiyun

2018-01-01

To examine whether curcumin has protective effect on insulin resistance induced by bisphenol A (BPA) in LO2 cells and whether this effect was mediated by inhibiting the inflammatory mitogen-activated protein kinases (MAPKs) and nuclear factor-κB (NF-κB) pathways. LO2 cells were stimulated with BPA in the presence or absence of curcumin for 5 days. Glucose consumption, activation of insulin signaling, MAPKs and NF-κB pathways, levels of inflammatory cytokines and MDA production were analyzed. Curcumin prevented BPA-induced reduction of glucose consumption and suppression of insulin signaling pathway, indicating curcumin alleviated BPA-triggered insulin resistance in LO2 cells. mRNA and proteins levels of TNF-α and IL-6, as well as MDA level in LO2 cells treated with BPA were decreased by curcumin. Furthermore, curcumin downregulated the activation of p38, JNK, and NF-κB pathways upon stimulation with BPA. Inhibition of JNK pathway, but not p38 nor NF-κB pathway, improved glucose consumption and insulin signaling in BPA-treated LO2 cells. Curcumin inhibits BPA-induced insulin resistance by suppressing JNK pathway. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Fast Calcium Imaging with Optical Sectioning via HiLo Microscopy.

PubMed

Lauterbach, Marcel A; Ronzitti, Emiliano; Sternberg, Jenna R; Wyart, Claire; Emiliani, Valentina

2015-01-01

Imaging intracellular calcium concentration via reporters that change their fluorescence properties upon binding of calcium, referred to as calcium imaging, has revolutionized our way to probe neuronal activity non-invasively. To reach neurons densely located deep in the tissue, optical sectioning at high rate of acquisition is necessary but difficult to achieve in a cost effective manner. Here we implement an accessible solution relying on HiLo microscopy to provide robust optical sectioning with a high frame rate in vivo. We show that large calcium signals can be recorded from dense neuronal populations at high acquisition rates. We quantify the optical sectioning capabilities and demonstrate the benefits of HiLo microscopy compared to wide-field microscopy for calcium imaging and 3D reconstruction. We apply HiLo microscopy to functional calcium imaging at 100 frames per second deep in biological tissues. This approach enables us to discriminate neuronal activity of motor neurons from different depths in the spinal cord of zebrafish embryos. We observe distinct time courses of calcium signals in somata and axons. We show that our method enables to remove large fluctuations of the background fluorescence. All together our setup can be implemented to provide efficient optical sectioning in vivo at low cost on a wide range of existing microscopes.

Fast Calcium Imaging with Optical Sectioning via HiLo Microscopy

PubMed Central

Sternberg, Jenna R.; Wyart, Claire; Emiliani, Valentina

2015-01-01

Imaging intracellular calcium concentration via reporters that change their fluorescence properties upon binding of calcium, referred to as calcium imaging, has revolutionized our way to probe neuronal activity non-invasively. To reach neurons densely located deep in the tissue, optical sectioning at high rate of acquisition is necessary but difficult to achieve in a cost effective manner. Here we implement an accessible solution relying on HiLo microscopy to provide robust optical sectioning with a high frame rate in vivo. We show that large calcium signals can be recorded from dense neuronal populations at high acquisition rates. We quantify the optical sectioning capabilities and demonstrate the benefits of HiLo microscopy compared to wide-field microscopy for calcium imaging and 3D reconstruction. We apply HiLo microscopy to functional calcium imaging at 100 frames per second deep in biological tissues. This approach enables us to discriminate neuronal activity of motor neurons from different depths in the spinal cord of zebrafish embryos. We observe distinct time courses of calcium signals in somata and axons. We show that our method enables to remove large fluctuations of the background fluorescence. All together our setup can be implemented to provide efficient optical sectioning in vivo at low cost on a wide range of existing microscopes. PMID:26625116

Perception of Western Musical Modes: A Chinese Study.

PubMed

Fang, Lele; Shang, Junchen; Chen, Nan

2017-01-01

The major mode conveys positive emotion, whereas the minor mode conveys negative emotion. However, previous studies have primarily focused on the emotions induced by Western music in Western participants. The influence of the musical mode (major or minor) on Chinese individuals' perception of Western music is unclear. In the present experiments, we investigated the effects of musical mode and harmonic complexity on psychological perception among Chinese participants. In Experiment 1, the participants ( N = 30) evaluated 24 musical excerpts in five dimensions (pleasure, arousal, dominance, emotional tension, and liking). In Experiment 2, the participants ( N = 40) evaluated 48 musical excerpts. Perceptions of the musical excerpts differed significantly according to mode, even if the stimuli were Western musical excerpts. The major-mode music induced greater pleasure and arousal and produced higher liking ratings than the minor-mode music, whereas the minor-mode music induced greater tension than the major-mode music. Mode did not influence the dominance rating. Perception of Western music was not influenced by harmonic complexity. Moreover, preference for musical mode was influenced by previous exposure to Western music. These results confirm the cross-cultural emotion induction effects of musical modes in Western music.

Mode coupling in hybrid square-rectangular lasers for single mode operation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ma, Xiu-Wen; Huang, Yong-Zhen, E-mail: yzhuang@semi.ac.cn; Yang, Yue-De

Mode coupling between a square microcavity and a Fabry-Pérot (FP) cavity is proposed and demonstrated for realizing single mode lasers. The modulations of the mode Q factor as simulation results are observed and single mode operation is obtained with a side mode suppression ratio of 46 dB and a single mode fiber coupling loss of 3.2 dB for an AlGaInAs/InP hybrid laser as a 300-μm-length and 1.5-μm-wide FP cavity connected to a vertex of a 10-μm-side square microcavity. Furthermore, tunable single mode operation is demonstrated with a continuous wavelength tuning range over 10 nm. The simple hybrid structure may shed light on practicalmore » applications of whispering-gallery mode microcavities in large-scale photonic integrated circuits and optical communication and interconnection.« less

Finite Larmor radius effects on the (m = 2, n = 1) cylindrical tearing mode

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Y.; Chowdhury, J.; Parker, S. E.

2015-04-15

New field solvers are developed in the gyrokinetic code GEM [Chen and Parker, J. Comput. Phys. 220, 839 (2007)] to simulate low-n modes. A novel discretization is developed for the ion polarization term in the gyrokinetic vorticity equation. An eigenmode analysis with finite Larmor radius effects is developed to study the linear resistive tearing mode. The mode growth rate is shown to scale with resistivity as γ ∼ η{sup 1∕3}, the same as the semi-collisional regime in previous kinetic treatments [Drake and Lee, Phys. Fluids 20, 1341 (1977)]. Tearing mode simulations with gyrokinetic ions are verified with the eigenmode calculation.

Femtosecond pulse inscription of a selective mode filter in large mode area fibers

NASA Astrophysics Data System (ADS)

Krämer, Ria G.; Voigtländer, Christian; Freier, Erik; Liem, Andreas; Thomas, Jens U.; Richter, Daniel; Schreiber, Thomas; Tünnermann, Andreas; Nolte, Stefan

2013-02-01

We present a selective mode filter inscribed with ultrashort pulses directly into a few mode large mode area (LMA) fiber. The mode filter consists of two refractive index modifications alongside the fiber core in the cladding. The refractive index modifications, which were of approximately the same order of magnitude as the refractive index difference between core and cladding have been inscribed by nonlinear absorption of femtosecond laser pulses (800 nm wavelength, 120 fs pulse duration). If light is guided in the core, it will interact with the inscribed modifications causing modes to be coupled out of the core. In order to characterize the mode filter, we used a femtosecond inscribed fiber Bragg grating (FBG), which acts as a wavelength and therefore mode selective element in the LMA fiber. Since each mode has different Bragg reflection wavelengths, an FBG in a multimode fiber will exhibit multiple Bragg reflection peaks. In our experiments, we first inscribed the FBG using the phase mask scanning technique. Then the mode filter was inscribed. The reflection spectrum of the FBG was measured in situ during the inscription process using a supercontinuum source. The reflectivities of the LP01 and LP11 modes show a dependency on the length of the mode filter. Two stages of the filter were obtained: one, in which the LP11 mode was reduced by 60% and one where the LP01 mode was reduced by 80%. The other mode respectively showed almost no losses. In conclusion, we could selectively filter either the fundamental or higher order modes.

List mode multichannel analyzer

DOEpatents

Archer, Daniel E [Livermore, CA; Luke, S John [Pleasanton, CA; Mauger, G Joseph [Livermore, CA; Riot, Vincent J [Berkeley, CA; Knapp, David A [Livermore, CA

2007-08-07

A digital list mode multichannel analyzer (MCA) built around a programmable FPGA device for onboard data analysis and on-the-fly modification of system detection/operating parameters, and capable of collecting and processing data in very small time bins (<1 millisecond) when used in histogramming mode, or in list mode as a list mode MCA.

Symbolic computation of the Hartree-Fock energy from a chiral EFT three-nucleon interaction at N 2LO

NASA Astrophysics Data System (ADS)

Gebremariam, B.; Bogner, S. K.; Duguet, T.

2010-06-01

We present the first of a two-part Mathematica notebook collection that implements a symbolic approach for the application of the density matrix expansion (DME) to the Hartree-Fock (HF) energy from a chiral effective field theory (EFT) three-nucleon interaction at N 2LO. The final output from the notebooks is a Skyrme-like energy density functional that provides a quasi-local approximation to the non-local HF energy. In this paper, we discuss the derivation of the HF energy and its simplification in terms of the scalar/vector-isoscalar/isovector parts of the one-body density matrix. Furthermore, a set of steps is described and illustrated on how to extend the approach to other three-nucleon interactions. Program summaryProgram title: SymbHFNNN Catalogue identifier: AEGC_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEGC_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 96 666 No. of bytes in distributed program, including test data, etc.: 378 083 Distribution format: tar.gz Programming language: Mathematica 7.1 Computer: Any computer running Mathematica 6.0 and later versions Operating system: Windows Xp, Linux/Unix RAM: 256 Mb Classification: 5, 17.16, 17.22 Nature of problem: The calculation of the HF energy from the chiral EFT three-nucleon interaction at N 2LO involves tremendous spin-isospin algebra. The problem is compounded by the need to eventually obtain a quasi-local approximation to the HF energy, which requires the HF energy to be expressed in terms of scalar/vector-isoscalar/isovector parts of the one-body density matrix. The Mathematica notebooks discussed in this paper solve the latter issue. Solution method: The HF energy from the chiral EFT three-nucleon interaction at N 2LO is cast into a form suitable for an automatic simplification of

Prediction of the binding mode of N2-phenylguanine derivative inhibitors to herpes simplex virus type 1 thymidine kinase

NASA Astrophysics Data System (ADS)

Gaudio, Anderson Coser; Takahata, Yuji; Richards, William Graham

1998-01-01

The probable binding mode of the herpes simplex virus thymidine kinase (HSV1 TK) N2-[substituted]-phenylguanine inhibitors is proposed. A computational experiment was designed to check some qualitative binding parameters and to calculate the interaction binding energies of alternative binding modes of N2-phenylguanines. The known binding modes of the HSV1 TK natural substrate deoxythymidine and one of its competitive inhibitors ganciclovir were used as templates. Both the qualitative and quantitative parts of the computational experiment indicated that the N2-phenylguanine derivatives bind to the HSV1 TK active site in the deoxythymidine-like binding mode. An experimental observation that N2-phenylguanosine derivatives are not phosphorylated during the interaction with the HSV1 TK gives support to the proposed binding mode.

Inter-comb synchronization by mode-to-mode locking

NASA Astrophysics Data System (ADS)

Chun, Byung Jae; Kim, Young-Jin; Kim, Seung-Woo

2016-08-01

Two combs of fiber femtosecond lasers are synchronized through the optical frequency reference created by injection-locking of a diode laser to a single comb mode. Maintaining a mHz-level narrow linewidth, the optical frequency reference permits two combs to be stabilized by mode-to-mode locking with a relative stability of 1.52  ×  10-16 at 10 s with a frequency slip of 2.46 mHz. This inter-comb synchronization can be utilized for applications such as dual-comb spectroscopy or ultra-short pulse synthesis without extra narrow-linewidth lasers.

Effective refractive index and first-order-mode cutoff conditions in InGaAsP/InP DH laser structures /lambda = 1.2-1.6 microns/

NASA Technical Reports Server (NTRS)

Botez, D.

1982-01-01

A highly accurate analytical expression for the effective refractive index in In GaAsP/InP DH lasers emitting in the 1.2-1.6 micron range is presented. This closed-form expression is used to derive simple wavelength-independent expressions for the first-order mode cutoff conditions of various lateral waveguides. The effective refractive index is a function of emission wavelength and active layer thickness, and the mode cutoff conditions are compared to experimental data from mode-stabilized 1.3 and 1.55 micron DH lasers.

Gyrokinetic simulation of ITG modes in a three-mode coupling model

NASA Astrophysics Data System (ADS)

Jenkins, Thomas G.; Lee, W. W.

2004-11-01

A three-mode coupling model of ITG modes with adiabatic electrons is studied both analytically and numerically in 2-dimensional slab geometry using the gyrokinetic formalism. It can be shown analytically that the (quasilinear) saturation amplitude of the waves in the system should be enhanced by the inclusion of the parallel velocity nonlinearity in the governing gyrokinetic equation. The effect of this (frequently neglected) nonlinearity on the steady-state transport properties of the plasma is studied numerically using standard gyrokinetic particle simulation techniques. The balance [1] between various steady-state transport properties of the model (particle and heat flux, entropy production, and collisional dissipation) is examined. Effects resulting from the inclusion of nonadiabatic electrons in the model are also considered numerically, making use of the gyrokinetic split-weight scheme [2] in the simulations. [1] W. W. Lee and W. M. Tang, Phys. Fluids 31, 612 (1988). [2] I. Manuilskiy and W. W. Lee, Phys. Plasmas 7, 1381 (2000).

A Hubble Space Telescope imaging study of four FeLoBAL quasar host galaxies

NASA Astrophysics Data System (ADS)

Lawther, D.; Vestergaard, M.; Fan, X.

2018-04-01

We study the host galaxies of four Iron Low-Ionization Broad Absorption-line Quasars (FeLoBALs), using Hubble Space Telescope imaging data, investigating the possibility that they represent a transition between an obscured active galactic nucleus (AGN) and an ordinary optical quasar. In this scenario, the FeLoBALs represent the early stage of merger-triggered accretion, in which case their host galaxies are expected to show signs of an ongoing or recent merger. Using PSF subtraction techniques, we decompose the images into host galaxy and AGN components at rest-frame ultraviolet and optical wavelengths. The ultraviolet is sensitive to young stars, while the optical probes stellar mass. In the ultraviolet we image at the BAL absorption trough wavelengths so as to decrease the contrast between the quasar and host galaxy emission. We securely detect an extended source for two of the four FeLoBALs in the rest-frame optical; a third host galaxy is marginally detected. In the rest-frame UV we detect no host emission; this constrains the level of unobscured star formation. Thus, the host galaxies have observed properties that are consistent with those of non-BAL quasars with the same nuclear luminosity, i.e. quiescent or moderately star-forming elliptical galaxies. However, we cannot exclude starbursting hosts that have the stellar UV emission obscured by modest amounts of dust reddening. Thus, our findings also allow the merger-induced young quasar scenario. For three objects, we identify possible close companion galaxies that may be gravitationally interacting with the quasar hosts.

1.34 µm picosecond self-mode-locked Nd:GdVO4 watt-level laser

NASA Astrophysics Data System (ADS)

Han, Ming; Peng, Jiying; Li, Zuohan; Cao, Qiuyuan; Yuan, Ruixia

2017-01-01

With a simple linear configuration, a diode-pumped, self-mode-locked Nd:GdVO4 laser at 1.34 µm is experimentally demonstrated for the first time. Based on the aberrationless theory of self-focusing and thermal lensing effect, through designing and optimizing the resonator, a pulse width as short as 9.1 ps is generated at a repetition rate of 2.0 GHz and the average output power is 2.51 W. The optical conversion efficiency and the slope efficiency for the stable mode-locked operation are approximately 16.7% and 19.2%, respectively.

A theory of growing crystalline nanorods - Mode I

NASA Astrophysics Data System (ADS)

Du, Feng; Huang, Hanchen

2018-08-01

Nanorods grow in two possible modes during physical vapor deposition (PVD). In mode I, monolayer surface steps dictate the diameter of nanorods. In mode II, multiple-layer surface steps dictate the diameter, which is the smallest possible under physical vapor deposition [5,10]. This paper reports closed-form theories of terrace lengths and nanorod diameter during the growth in mode I, as a function of deposition conditions. The accompanying lattice kinetic Monte Carlo simulations verify these theories. This study reveals that (1) quasi-steady growth exists for each set of nanorod growth conditions, and (2) the characteristic length scales, including terrace lengths and nanorod diameter at the quasi-steady state, depend on the deposition conditions - deposition rate F, substrate temperature T, and incidence angle θ - only as a function of l2D/tan θ, with l2 D = 2(v2 D/Fcosθ) 1/3 as a diffusion-limited length scale and v2D as the atomic diffusion jump rate over monolayer surface steps.

Lo Gnomone Clementino Astronomia Meridiana in Basilica

NASA Astrophysics Data System (ADS)

Sigismondi, Costantino

2014-05-01

Costruito per chiara volontà del papa 70 anni dopo il caso Galileo, lo Gnomone Clementino è un grande telescopio solare che non fa uso di lenti a 92 anni dall’invenzione del cannocchiale. Queste due caratteristiche basterebbero da sole a giustificare l’interesse verso questo strumento. L’astronomia meridiana è alla base dell’astrometria e dell’astrofisica moderna. Lo Gnomone Clementino sta oggi all’astronomia, come il veliero “Amerigo Vespucci” sta alla Marina Italiana. E’ possibile svolgere ogni genere di osservazione e studio su questo strumento, e dal 2002 vi tengo lezioni teorico-pratiche del corso di Storia dell’Astronomia e La Terra nel Sistema Solare della Sapienza, Università di Roma, Facoltà di Lettere e Filosofia. Questo testo aggiunge alcuni tasselli alla ricerca storica sulla meridiana, appoggiandosi, com’è naturale, sulle spalle di giganti che mi hanno preceduto in questi studi. In particolare la misura dell’azimut della meridiana, ed il suo inquadramento tra gli strumenti simili ed alcuni studi di astrometria sui dati del 1701-1703 di Bianchini, che sono apparsi fin’ora soltanto su riviste specializzate ed in Inglese vengono qui proposti in Italiano e semplificati, per valorizzare sempre più questa straordinaria opera d’arte e di scienza.

Detailed Analysis of the Binding Mode of Vanilloids to Transient Receptor Potential Vanilloid Type I (TRPV1) by a Mutational and Computational Study

PubMed Central

Mori, Yoshikazu; Ogawa, Kazuo; Warabi, Eiji; Yamamoto, Masahiro; Hirokawa, Takatsugu

2016-01-01

Transient receptor potential vanilloid type 1 (TRPV1) is a non-selective cation channel and a multimodal sensor protein. Since the precise structure of TRPV1 was obtained by electron cryo-microscopy, the binding mode of representative agonists such as capsaicin and resiniferatoxin (RTX) has been extensively characterized; however, detailed information on the binding mode of other vanilloids remains lacking. In this study, mutational analysis of human TRPV1 was performed, and four agonists (capsaicin, RTX, [6]-shogaol and [6]-gingerol) were used to identify amino acid residues involved in ligand binding and/or modulation of proton sensitivity. The detailed binding mode of each ligand was then simulated by computational analysis. As a result, three amino acids (L518, F591 and L670) were newly identified as being involved in ligand binding and/or modulation of proton sensitivity. In addition, in silico docking simulation and a subsequent mutational study suggested that [6]-gingerol might bind to and activate TRPV1 in a unique manner. These results provide novel insights into the binding mode of various vanilloids to the channel and will be helpful in developing a TRPV1 modulator. PMID:27606946

Investigating light curve modulation via kernel smoothing. II. New additional modes in single-mode OGLE classical Cepheids

NASA Astrophysics Data System (ADS)

Süveges, Maria; Anderson, Richard I.

2018-04-01

Detailed knowledge of the variability of classical Cepheids, in particular their modulations and mode composition, provides crucial insight into stellar structure and pulsation. However, tiny modulations of the dominant radial-mode pulsation were recently found to be very frequent, possibly ubiquitous in Cepheids, which makes secondary modes difficult to detect and analyse, since these modulations can easily mask the potentially weak secondary modes. The aim of this study is to re-investigate the secondary mode content in the sample of OGLE-III and -IV single-mode classical Cepheids using kernel regression with adaptive kernel width for pre-whitening, instead of using a constant-parameter model. This leads to a more precise removal of the modulated dominant pulsation, and enables a more complete survey of secondary modes with frequencies outside a narrow range around the primary. Our analysis reveals that significant secondary modes occur more frequently among first overtone Cepheids than previously thought. The mode composition appears significantly different in the Large and Small Magellanic Clouds, suggesting a possible dependence on chemical composition. In addition to the formerly identified non-radial mode at P2 ≈ 0.6…0.65P1 (0.62-mode), and a cluster of modes with near-primary frequency, we find two more candidate non-radial modes. One is a numerous group of secondary modes with P2 ≈ 1.25P1, which may represent the fundamental of the 0.62-mode, supposed to be the first harmonic of an l ∈ {7, 8, 9} non-radial mode. The other new mode is at P2 ≈ 1.46P1, possibly analogous to a similar, rare mode recently discovered among first overtone RR Lyrae stars.

Mode selection in square resonator microlasers for widely tunable single mode lasing.

PubMed

Tang, Ming-Ying; Sui, Shao-Shuai; Yang, Yue-De; Xiao, Jin-Long; Du, Yun; Huang, Yong-Zhen

2015-10-19

Mode selection in square resonator semiconductor microlasers is demonstrated by adjusting the width of the output waveguide coupled to the midpoint of one side. The simulation and experimental results reveal that widely tunable single mode lasing can be realized in square resonator microlasers. Through adjusting the width of the output waveguide, the mode interval of the high-Q modes can reach four times of the longitudinal mode interval. Therefore, mode hopping can be efficiently avoided and the lasing wavelength can be tuned continuously by tuning the injection current. For a 17.8-μm-side-length square microlaser with a 1.4-μm-width output waveguide, mode-hopping-free single-mode operation is achieved with a continuous tuning range of 9.2 nm. As a result, the control of the lasing mode is realized for the square microlasers.

Toxicity and mode of action of insecticidal Cry1A proteins from Bacillus thuringiensis in an insect cell line, CF-1.

PubMed

Portugal, Leivi; Gringorten, J Lawrence; Caputo, Guido F; Soberón, Mario; Muñoz-Garay, Carlos; Bravo, Alejandra

2014-03-01

Bacillus thuringiensis Cry toxins are insecticidal proteins used to control insect pests. The interaction of Cry toxins with the midgut of susceptible insects is a dynamic process involving activation of the toxin, binding to midgut receptors in the apical epithelium and conformational changes in the toxin molecule, leading to pore formation and cell lysis. An understanding of the molecular events underlying toxin mode of action is essential for the continued use of Cry toxins. In this work, we examined the mechanism of action of Cry1A toxins in the lepidopteran cell line CF-1, using native Cry1Ab and mutant forms of this protein that interfer with different steps in the mechanism of action, specifically, receptor binding, oligomerization or pore formation. These mutants lost activity against both Manduca sexta larvae and CF-1 cells. We also analyzed a mutation created in domain I of Cry1Ab, in which helix α-1 and part of helix α-2 were deleted (Cry1AbMod). Cry1AbMod is able to oligomerize in the absence of toxin receptors, and although it shows reduced activity against some susceptible insects, it kills insect pests that have developed resistance to native Cry1Ab. Cry1AbMod showed enhanced toxicity to CF-1, suggesting that oligomerization of native Cry1Ab may be a limiting step in its activity against CF-1 cells. The toxicity of Cry1Ac and Cry1AcMod were also analyzed. Our results suggest that some of the steps in the mode of action of Cry1A toxins are conserved in vivo in insect midgut cells and in vitro in an established cell line, CF-1. Copyright © 2013 Elsevier Inc. All rights reserved.

Relaxation of a hot-electron-two-mode-phonon system in highly excited CdS1-xSex crystals

NASA Astrophysics Data System (ADS)

Žukauskas, A.; Juršėnas, S.

1995-02-01

An investigation of the electron-hole-plasma effective-temperature relaxation in highly excited CdS1-xSex mixed crystals is presented. The slow (~100-ps) relaxation stage, attributed to the depopulation of the fragments (decay products) of the initially produced nonequilibrium LO phonons, is examined with variation of the alloy composition. The relevant relaxation time dependence on x exhibiting a remarkable drop at small CdSe mole fractions is analyzed in terms of a two-route energy relaxation model considering hot-carrier plasma and two generations of nonequilibrium phonons each originating from both pure constituents of the alloy. The disorder-enhanced cross relaxation between two sublattices of the alloy is inferred to account for the experimental results.

A human transcription factor in search mode.

PubMed

Hauser, Kevin; Essuman, Bernard; He, Yiqing; Coutsias, Evangelos; Garcia-Diaz, Miguel; Simmerling, Carlos

2016-01-08

Transcription factors (TF) can change shape to bind and recognize DNA, shifting the energy landscape from a weak binding, rapid search mode to a higher affinity recognition mode. However, the mechanism(s) driving this conformational change remains unresolved and in most cases high-resolution structures of the non-specific complexes are unavailable. Here, we investigate the conformational switch of the human mitochondrial transcription termination factor MTERF1, which has a modular, superhelical topology complementary to DNA. Our goal was to characterize the details of the non-specific search mode to complement the crystal structure of the specific binding complex, providing a basis for understanding the recognition mechanism. In the specific complex, MTERF1 binds a significantly distorted and unwound DNA structure, exhibiting a protein conformation incompatible with binding to B-form DNA. In contrast, our simulations of apo MTERF1 revealed significant flexibility, sampling structures with superhelical pitch and radius complementary to the major groove of B-DNA. Docking these structures to B-DNA followed by unrestrained MD simulations led to a stable complex in which MTERF1 was observed to undergo spontaneous diffusion on the DNA. Overall, the data support an MTERF1-DNA binding and recognition mechanism driven by intrinsic dynamics of the MTERF1 superhelical topology. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

Novel modes and adaptive block scanning order for intra prediction in AV1

NASA Astrophysics Data System (ADS)

Hadar, Ofer; Shleifer, Ariel; Mukherjee, Debargha; Joshi, Urvang; Mazar, Itai; Yuzvinsky, Michael; Tavor, Nitzan; Itzhak, Nati; Birman, Raz

2017-09-01

The demand for streaming video content is on the rise and growing exponentially. Networks bandwidth is very costly and therefore there is a constant effort to improve video compression rates and enable the sending of reduced data volumes while retaining quality of experience (QoE). One basic feature that utilizes the spatial correlation of pixels for video compression is Intra-Prediction, which determines the codec's compression efficiency. Intra prediction enables significant reduction of the Intra-Frame (I frame) size and, therefore, contributes to efficient exploitation of bandwidth. In this presentation, we propose new Intra-Prediction algorithms that improve the AV1 prediction model and provide better compression ratios. Two (2) types of methods are considered: )1( New scanning order method that maximizes spatial correlation in order to reduce prediction error; and )2( New Intra-Prediction modes implementation in AVI. Modern video coding standards, including AVI codec, utilize fixed scan orders in processing blocks during intra coding. The fixed scan orders typically result in residual blocks with high prediction error mainly in blocks with edges. This means that the fixed scan orders cannot fully exploit the content-adaptive spatial correlations between adjacent blocks, thus the bitrate after compression tends to be large. To reduce the bitrate induced by inaccurate intra prediction, the proposed approach adaptively chooses the scanning order of blocks according to criteria of firstly predicting blocks with maximum number of surrounding, already Inter-Predicted blocks. Using the modified scanning order method and the new modes has reduced the MSE by up to five (5) times when compared to conventional TM mode / Raster scan and up to two (2) times when compared to conventional CALIC mode / Raster scan, depending on the image characteristics (which determines the percentage of blocks predicted with Inter-Prediction, which in turn impacts the efficiency of the new

A streamlined failure mode and effects analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ford, Eric C., E-mail: eford@uw.edu; Smith, Koren; Terezakis, Stephanie

Purpose: Explore the feasibility and impact of a streamlined failure mode and effects analysis (FMEA) using a structured process that is designed to minimize staff effort. Methods: FMEA for the external beam process was conducted at an affiliate radiation oncology center that treats approximately 60 patients per day. A structured FMEA process was developed which included clearly defined roles and goals for each phase. A core group of seven people was identified and a facilitator was chosen to lead the effort. Failure modes were identified and scored according to the FMEA formalism. A risk priority number,RPN, was calculated and usedmore » to rank failure modes. Failure modes with RPN > 150 received safety improvement interventions. Staff effort was carefully tracked throughout the project. Results: Fifty-two failure modes were identified, 22 collected during meetings, and 30 from take-home worksheets. The four top-ranked failure modes were: delay in film check, missing pacemaker protocol/consent, critical structures not contoured, and pregnant patient simulated without the team's knowledge of the pregnancy. These four failure modes hadRPN > 150 and received safety interventions. The FMEA was completed in one month in four 1-h meetings. A total of 55 staff hours were required and, additionally, 20 h by the facilitator. Conclusions: Streamlined FMEA provides a means of accomplishing a relatively large-scale analysis with modest effort. One potential value of FMEA is that it potentially provides a means of measuring the impact of quality improvement efforts through a reduction in risk scores. Future study of this possibility is needed.« less

A streamlined failure mode and effects analysis.

PubMed

Ford, Eric C; Smith, Koren; Terezakis, Stephanie; Croog, Victoria; Gollamudi, Smitha; Gage, Irene; Keck, Jordie; DeWeese, Theodore; Sibley, Greg

2014-06-01

Explore the feasibility and impact of a streamlined failure mode and effects analysis (FMEA) using a structured process that is designed to minimize staff effort. FMEA for the external beam process was conducted at an affiliate radiation oncology center that treats approximately 60 patients per day. A structured FMEA process was developed which included clearly defined roles and goals for each phase. A core group of seven people was identified and a facilitator was chosen to lead the effort. Failure modes were identified and scored according to the FMEA formalism. A risk priority number,RPN, was calculated and used to rank failure modes. Failure modes with RPN > 150 received safety improvement interventions. Staff effort was carefully tracked throughout the project. Fifty-two failure modes were identified, 22 collected during meetings, and 30 from take-home worksheets. The four top-ranked failure modes were: delay in film check, missing pacemaker protocol/consent, critical structures not contoured, and pregnant patient simulated without the team's knowledge of the pregnancy. These four failure modes had RPN > 150 and received safety interventions. The FMEA was completed in one month in four 1-h meetings. A total of 55 staff hours were required and, additionally, 20 h by the facilitator. Streamlined FMEA provides a means of accomplishing a relatively large-scale analysis with modest effort. One potential value of FMEA is that it potentially provides a means of measuring the impact of quality improvement efforts through a reduction in risk scores. Future study of this possibility is needed.

Bernstein modes in a non-neutral plasma column

NASA Astrophysics Data System (ADS)

Walsh, Daniel; Dubin, Daniel H. E.

2018-05-01

This paper presents theory and numerical calculations of electrostatic Bernstein modes in an inhomogeneous cylindrical plasma column. These modes rely on finite Larmor radius effects to propagate radially across the column until they are reflected when their frequency matches the upper hybrid frequency. This reflection sets up an internal normal mode on the column and also mode-couples to the electrostatic surface cyclotron wave (which allows the normal mode to be excited and observed using external electrodes). Numerical results predicting the mode spectra, using a novel linear Vlasov code on a cylindrical grid, are presented and compared to an analytical Wentzel Kramers Brillouin (WKB) theory. A previous version of the theory [D. H. E. Dubin, Phys. Plasmas 20(4), 042120 (2013)] expanded the plasma response in powers of 1/B, approximating the local upper hybrid frequency, and consequently, its frequency predictions are spuriously shifted with respect to the numerical results presented here. A new version of the WKB theory avoids this approximation using the exact cold fluid plasma response and does a better job of reproducing the numerical frequency spectrum. The effect of multiple ion species on the mode spectrum is also considered, to make contact with experiments that observe cyclotron modes in a multi-species pure ion plasma [M. Affolter et al., Phys. Plasmas 22(5), 055701 (2015)].

CXCR6 marks a novel subset of T-bet(lo)Eomes(hi) natural killer cells residing in human liver.

PubMed

Stegmann, Kerstin A; Robertson, Francis; Hansi, Navjyot; Gill, Upkar; Pallant, Celeste; Christophides, Theodoros; Pallett, Laura J; Peppa, Dimitra; Dunn, Claire; Fusai, Giuseppe; Male, Victoria; Davidson, Brian R; Kennedy, Patrick; Maini, Mala K

2016-05-23

Natural killer cells (NK) are highly enriched in the human liver, where they can regulate immunity and immunopathology. We probed them for a liver-resident subset, distinct from conventional bone-marrow-derived NK. CXCR6+ NK were strikingly enriched in healthy and diseased liver compared to blood (p < 0.0001). Human hepatic CXCR6+ NK had an immature phenotype (predominantly CD56(bright)CD16-CD57-), and expressed the tissue-residency marker CD69. CXCR6+ NK produced fewer cytotoxic mediators and pro-inflammatory cytokines than the non-liver-specific CXCR6- fraction. Instead CXCR6+ NK could upregulate TRAIL, a key death ligand in hepatitis pathogenesis. CXCR6 demarcated liver NK into two transcriptionally distinct populations: T-bet(hi)Eomes(lo)(CXCR6-) and T-bet(lo)Eomes(hi)(CXCR6+); the latter was virtually absent in the periphery. The small circulating CXCR6+ subset was predominantly T-bet(hi)Eomes(lo), suggesting its lineage was closer to CXCR6- peripheral than CXCR6+ liver NK. These data reveal a large subset of human liver-resident T-bet(lo)Eomes(hi) NK, distinguished by their surface expression of CXCR6, adapted for hepatic tolerance and inducible anti-viral immunity.

A Novel Damping Mechanism for Diocotron Modes

NASA Astrophysics Data System (ADS)

Chim, Chi Yung; O'Neil, Thomas M.

2014-10-01

Recent experiments with pure electron plasmas in a Malmberg-Penning trap have observed the algebraic damping of m = 1 and m = 2 diocotron modes. Transport due to small field asymmetries produces a low density halo of electrons moving radially outward from the plasma core, and the mode damping begins when the halo reaches the resonant radius, where f = mfE × B (r) . The damping rate is proportional to the flux of halo particles through the resonant layer. The damping is related to, but distinct from spatial Landau damping, in which a linear wave-particle resonance produces exponential damping. This poster explains with analytic theory and simulations the new algebraic damping due to both mobility and diffusive fluxes. The damping is due to transfer of canonical angular momentum from the mode to halo particles, as they are swept around the ``cat's eye'' orbits of resonant wave-particle interaction. Another picture is that the electrons in the resonant layer form a dipole (m = 1) or quadrupole (m = 2) density distribution, and the electric field for this distribution produces E × B drifts that symmetrizes the core and damps the mode. Supported by NSF/DOE Partnership Grants PHY-0903877 and DE-SC0002451.

Extraordinary optical transmission inside a waveguide: spatial mode dependence.

PubMed

Reichel, Kimberly S; Lu, Peter Y; Backus, Sterling; Mendis, Rajind; Mittleman, Daniel M

2016-12-12

We study the influence of the input spatial mode on the extraordinary optical transmission (EOT) effect. By placing a metal screen with a 1D array of subwavelength holes inside a terahertz (THz) parallel-plate waveguide (PPWG), we can directly compare the transmission spectra with different input waveguide modes. We observe that the transmitted spectrum depends strongly on the input mode. A conventional description of EOT based on the excitation of surface plasmons is not predictive in all cases. Instead, we utilize a formalism based on impedance matching, which accurately predicts the spectral resonances for both TEM and non-TEM input modes.

Accurate mode characterization of two-mode optical fibers by in-fiber acousto-optics.

PubMed

Alcusa-Sáez, E; Díez, A; Andrés, M V

2016-03-07

Acousto-optic interaction in optical fibers is exploited for the accurate and broadband characterization of two-mode optical fibers. Coupling between LP 01 and LP 1m modes is produced in a broadband wavelength range. Difference in effective indices, group indices, and chromatic dispersions between the guided modes, are obtained from experimental measurements. Additionally, we show that the technique is suitable to investigate the fine modes structure of LP modes, and some other intriguing features related with modes' cut-off.

Spectroscopic mode identification of γ Doradus stars: frequencies, modes, rotation and wave leakage

NASA Astrophysics Data System (ADS)

Pollard, Karen R.; Brunsden, E.; Davie, M.; Greenwood, A.; Cottrell, P. L.

The gravity modes present in γ Doradus stars probe the deep stellar interiors and are thus of particular interest in asteroseismology. The MUSICIAN programme at the University of Canterbury has been successfully identifying frequencies and pulsation modes in many γ Doradus stars using hundreds of precise, high resolution spectroscopic observations obtained with the 1.0 m telescope and HERCULES spectrograph at the Mt John Observatory in New Zealand. In this paper we present a summary of our spectroscopic frequency and mode identifications. Of particular interest from our spectroscopic analyses are: the prevalence of (l, m) = 1, 1 modes in many γ Dor stars; the importance of stellar rotation in the interpretation of the frequency and mode identification; and finally, possible evidence of wave leakage in one of these stars.

Goldstone-like phonon modes in a (111)-strained perovskite

NASA Astrophysics Data System (ADS)

Marthinsen, A.; Griffin, S. M.; Moreau, M.; Grande, T.; Tybell, T.; Selbach, S. M.

2018-01-01

Goldstone modes are massless particles resulting from spontaneous symmetry breaking. Although such modes are found in elementary particle physics as well as in condensed-matter systems like superfluid helium, superconductors, and magnons, structural Goldstone modes are rare. Epitaxial strain in thin films can induce structures and properties not accessible in bulk and has been intensively studied for (001)-oriented perovskite oxides. Here we predict Goldstone-like phonon modes in (111)-strained SrMn O3 by first-principles calculations. Under compressive strain the coupling between two in-plane rotational instabilities gives rise to a Mexican hat-shaped energy surface characteristic of a Goldstone mode. Conversely, large tensile strain induces in-plane polar instabilities with no directional preference, giving rise to a continuous polar ground state. Such phonon modes with U (1) symmetry could emulate structural condensed-matter Higgs modes. The mass of this Higgs boson, given by the shape of the Mexican hat energy surface, can be tuned by strain through proper choice of substrate.

Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation.

PubMed

Hsu, Hsi-Hsien; Chen, Ming-Cheng; Day, Cecilia Hsuan; Lin, Yueh-Min; Li, Shin-Yi; Tu, Chuan-Chou; Padma, Viswanadha Vijaya; Shih, Hui-Nung; Kuo, Wei-Wen; Huang, Chih-Yang

2017-02-21

To identify potential anti-cancer constituents in natural extracts that inhibit cancer cell growth and migration. Our experiments used high dose thymoquinone (TQ) as an inhibitor to arrest LoVo (a human colon adenocarcinoma cell line) cancer cell growth, which was detected by cell proliferation assay and immunoblotting assay. Low dose TQ did not significantly reduce LoVo cancer cell growth. Cyclooxygenase 2 (COX-2) is an enzyme that is involved in the conversion of arachidonic acid into prostaglandin E2 (PGE2) in humans. PGE2 can promote COX-2 protein expression and tumor cell proliferation and was used as a control. Our results showed that 20 μmol/L TQ significantly reduced human LoVo colon cancer cell proliferation. TQ treatment reduced the levels of p-PI3K, p-Akt, p-GSK3β, and β-catenin and thereby inhibited the downstream COX-2 expression. Results also showed that the reduction in COX-2 expression resulted in a reduction in PGE2 levels and the suppression of EP2 and EP4 activation. Further analysis showed that TG treatment inhibited the nuclear translocation of β-catenin in LoVo cancer cells. The levels of the cofactors LEF-1 and TCF-4 were also decreased in the nucleus following TQ treatment in a dose-dependent manner. Treatment with low dose TQ inhibited the COX-2 expression at the transcriptional level and the regulation of COX-2 expression efficiently reduced LoVo cell migration. The results were further verified in vivo by confirming the effects of TQ and/or PGE2 using tumor xenografts in nude mice. TQ inhibits LoVo cancer cell growth and migration, and this result highlights the therapeutic advantage of using TQ in combination therapy against colorectal cancer.

Modeling resistive wall modes and disruptive instabilities with M3D-C1

NASA Astrophysics Data System (ADS)

Ferraro, Nm; Jardin, Sc; Pfefferle, D.

2016-10-01

Disruptive instabilities pose a significant challenge to the tokamak approach to magnetic fusion energy, and must be reliably avoided in a successful reactor. These instabilities generally involve rapid, global changes to the magnetic field, and electromagnetic interaction with surrounding conducting structures. Here we apply the extended-MHD code M3D-C1 to calculate the stability and evolution of disruptive modes, including their interaction with external conducting structures. The M3D-C1 model includes the effects of resistivity, equilibrium rotation, and resistive walls of arbitrary thickness, each of which may play important roles in the stability and evolution of disruptive modes. The strong stabilizing effect of rotation on resistive wall modes is explored and compared with analytic theory. The nonlinear evolution of vertical displacement events is also considered, including the evolution of non-axisymmetric instabilities that may arise during the current-quench phase of the disruption. It is found that the non-axisymmetric stability of the plasma during a VDE depends strongly on the thermal history of the plasma. This work is supported by US DOE Grant DE-AC02-09CH11466 and the SciDAC Center for Extended MHD Modeling.

On the mechanism of transverse-mode beatings in a Fabry - Perot laser

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kumar, N; Ledenev, V I

2010-06-23

The mechanism of emergence of fundamental-mode and first-mode beatings in the case of a step-wise increase in the pump rate is studied under the stationary single-mode lasing conditions. Investigation is based on the numerical solution of nonstationary wave equations in a resonator in the quasi-optic approximation and on the equation for a relaxation-type medium as well as on the use of the first two Hermite - Gaussian polynomials {psi}{sub 0,1}(x) to obtain the distribution projections I{sub 0,1}(t), g{sub 0,1}(t) of the radiation intensity and gain, respectively. It is shown that the transverse-mode beatings emerge at early stages of two-mode lasing,more » the appearance of radiation intensity oscillations in the active medium preceding the development of the gain oscillations. The time of the passage of two-mode lasing to the stationary regime is determined. The phase shift {pi}/2 between the oscillations I{sub 1}(t) and g{sub 1}(t) is found for the established beating regime and the modulation depth {Delta}I averaged over the output aperture of the radiation intensity in the established two-mode regime is shown to be proportional to the pump rate excess k over the single-mode lasing threshold. A scheme for controlling the mode composition of laser radiation is proposed, which is based on the rules for determining I{sub 0,1}(t) by the sensor signals. The efficiency of the scheme is studied. The scheme employs two field intensity sensors mounted inside the resonator behind the output aperture. (resonators. modes)« less

Chemical composition of matrix-embedded ternary II-VI nanocrystals derived from first- and second-order Raman spectra

NASA Astrophysics Data System (ADS)

Azhniuk, Yu. M.; Hutych, Yu. I.; Lopushansky, V. V.; Prymak, M. V.; Gomonnai, A. V.; Zahn, D. R. T.

2016-12-01

A one- and multiphonon Raman scattering study is performed for an extensive set of CdS1-xSex, Cd1-yZnyS, Cd1-yZnySe, and CdSe1-xTex nanocrystals to investigate the applicability of first- and second-order Raman spectra for the determination of the matrix-embedded ternary nanocrystal composition. For one-mode ternary systems both the LO and 2LO phonon frequencies in the Raman spectra are shown to be a good measure of the nanocrystal composition. For two-mode systems, the approaches based on the difference of the LO phonon frequencies (first-order Raman spectra) or double LO overtone and combination tone frequencies (second-order Raman spectra) as well as on the LO phonon band intensity ratios are analysed. The weak electron-phonon coupling in the II-VI nanocrystals and the polaron constant values for the nanocrystal sublattices are discussed.

BabeLO--An Extensible Converter of Programming Exercises Formats

ERIC Educational Resources Information Center

Queiros, R.; Leal, J. P.

2013-01-01

In the last two decades, there was a proliferation of programming exercise formats that hinders interoperability in automatic assessment. In the lack of a widely accepted standard, a pragmatic solution is to convert content among the existing formats. BabeLO is a programming exercise converter providing services to a network of heterogeneous…

Establishing an Appropriate Level of Detail (LoD) for a Building Information Model (BIM) - West Block, Parliament Hill, Ottawa, Canada

NASA Astrophysics Data System (ADS)

Fai, S.; Rafeiro, J.

2014-05-01

In 2011, Public Works and Government Services Canada (PWGSC) embarked on a comprehensive rehabilitation of the historically significant West Block of Canada's Parliament Hill. With over 17 thousand square meters of floor space, the West Block is one of the largest projects of its kind in the world. As part of the rehabilitation, PWGSC is working with the Carleton Immersive Media Studio (CIMS) to develop a building information model (BIM) that can serve as maintenance and life-cycle management tool once construction is completed. The scale and complexity of the model have presented many challenges. One of these challenges is determining appropriate levels of detail (LoD). While still a matter of debate in the development of international BIM standards, LoD is further complicated in the context of heritage buildings because we must reconcile the LoD of the BIM with that used in the documentation process (terrestrial laser scan and photogrammetric survey data). In this paper, we will discuss our work to date on establishing appropriate LoD within the West Block BIM that will best serve the end use. To facilitate this, we have developed a single parametric model for gothic pointed arches that can be used for over seventy-five unique window types present in the West Block. Using the AEC (CAN) BIM as a reference, we have developed a workflow to test each of these window types at three distinct levels of detail. We have found that the parametric Gothic arch significantly reduces the amount of time necessary to develop scenarios to test appropriate LoD.

Inhibiting the TE1-mode diffraction losses in terahertz parallel-plate waveguides using concave plates.

PubMed

Mbonye, Marx; Mendis, Rajind; Mittleman, Daniel M

2012-12-03

We present numerical and experimental results on inhibiting diffraction losses associated with the lowest order transverse electric (TE1) mode of a terahertz (THz) parallel-plate waveguide (PPWG) via the use of slightly concave plates. We find that there is an optimal radius of curvature that inhibits the diffraction for a given waveguide operating at a given frequency. We also find that introducing this curvature does not introduce any additional group-velocity dispersion. These results support the possibility of realizing long range transport of THz radiation using the TE1 mode of the PPWG.

Constraining the Accretion Mode in LINER 1.9s

NASA Astrophysics Data System (ADS)

Sabra, Bassem; Der Sahaguian, Elias; Badr, Elie

2016-01-01

The accretion mode and the dominant power source in low-ionization nuclear emission-line regions (LINERs), a class of active galactic nuclei (AGN), are still elusive. We focus on a sample of 22 LINER 1.9s (Ho et al. 1997), a subclass of LINERs that show broad Halpha lines, a signature of blackhole-powered accretion, to test the hypothesis that the ionizing continuum emitted by a radiatively inefficient accretion flow (RIAF) could lead to the LINER ultraviolet (UV) emission-line ratios. Optical line-ratio diagrams are a weak diagnostic tool in distinguishing between possible power sources (Sabra et al. 2003). We search the Mikulski Archive for Space Telescopes (MAST) for UV spectra of the objects in the above sample and also perform photoionization simulations using CLOUDY (Ferland et al. 2013). Unfortunately, only one object (NGC 1052; Gabel et al. 2000) of the 22 LINER 1.9s has UV spectra that cover many emission lines; the rest of the objects either do not have any UV spectra, the spectral coverage is in-adequate, or the spectra have very low signal-to-noise ratios. Our photoionization simulations set up two identical grids of clouds with a range of densities and ionization parameters. We illuminate one grid with radiation emitted by a thin accretion disk (AD) and we illuminate the other grid with radiation from a RIAF. We overplot the UV emission-line ratio predictions for AD and RIAF illumination, together with the available line ratios for NGC 1052. Initial results show that UV lines could be used as diagnostics for the accretion mode in AGN. More UV spectral coverage of LINER 1.9s is needed in order to more fully utilize the diagnostic powers of UV emission line ratios.

A Solar Model with g-Modes

NASA Technical Reports Server (NTRS)

Wolff, Charles L.; Niemann, Hasso (Technical Monitor)

2002-01-01

Good evidence is assembled showing that the Suit's core arid surface vary on time scales from a month to a decade arid that a number of scales are similar. The most plausible source for numerous long time scales and periodicities is long-lived global oscillations. This suggests g-modes (oscillations restored mainly by buoyancy) because they particularly affect the core and base of the convective envelope, which then indirectly modulates the surface. Also, standing g-modes have rotational properties that match many observed periodicities. But the standard solar model (SSM) has a static core and excites few if any g-modes. making new interior structures worth exploring. The model outlined here assumes two well mixed shells near 0.18 and 0.68 R, (13 = solar radius) where sound speed data shows sharp deviations from the SSM. Mixing is sustained by flows driven by the oscillations. The shells form a cavity that excludes g-modes from their main damping region below 0.1 R, assisting their net excitation and increasing their oscillation periods by at least a factor of two and probably much more. In terms of the solar luminosity L, the modes transport up through the cavity a power approx. 0.004 L as a lower limit and 0.11 L as all upper limit. The modes dissipate energy in the outer shell and cool the inner shell, asymmetrically in each case, and this stimulates occasional convective events whose response time is typically 0.8 years longer near the inner shell. Such events cool the core and reduce neutrino flux while heating the envelope and increasing solar activity. This gives a physical basis for a well mixed Sun with low neutrino flux and basis for the observed anticorrelation and lag of neutrino behind surface activity.

Mode- and plasma rotation in a resistive shell reversed-field pinch

NASA Astrophysics Data System (ADS)

Malmberg, J.-A.; Brzozowski, J.; Brunsell, P. R.; Cecconello, M.; Drake, J. R.

2004-02-01

Mode rotation studies in a resistive shell reversed-field pinch, EXTRAP T2R [P. R. Brunsell et al., Plasma Phys. Control. Fusion 43, 1 (2001)] are presented. The phase relations and nonlinear coupling of the resonant modes are characterized and compared with that expected from modeling based on the hypothesis that mode dynamics can be described by a quasi stationary force balance including electromagnetic and viscous forces. Both m=0 and m=1 resonant modes are studied. The m=1 modes have rotation velocities corresponding to the plasma flow velocity (20-60 km/s) in the core region. The rotation velocity decreases towards the end of the discharge, although the plasma flow velocity does not decrease. A rotating phase locked m=1 structure is observed with a velocity of about 60 km/s. The m=0 modes accelerate throughout the discharges and reach velocities as high as 150-250 km/s. The observed m=0 phase locking is consistent with theory for certain conditions, but there are several conditions when the dynamics are not described. This is not unexpected because the assumption of quasi stationarity for the mode spectra is not fulfilled for many conditions. Localized m=0 perturbations are formed in correlation with highly transient discrete dynamo events. These perturbations form at the location of the m=1 phase locked structure, but rotate with a different velocity as they spread out in the toroidal direction.

Linearly polarized vector modes: enabling MIMO-free mode-division multiplexing.

PubMed

Wang, Lixian; Nejad, Reza Mirzaei; Corsi, Alessandro; Lin, Jiachuan; Messaddeq, Younès; Rusch, Leslie; LaRochelle, Sophie

2017-05-15

We experimentally investigate mode-division multiplexing in an elliptical ring core fiber (ERCF) that supports linearly polarized vector modes (LPV). Characterization show that the ERCF exhibits good polarization maintaining properties over eight LPV modes with effective index difference larger than 1 × 10 -4 . The ERCF further displays stable mode power and polarization extinction ratio when subjected to external perturbations. Crosstalk between the LPV modes, after propagating through 0.9 km ERCF, is below -14 dB. By using six LPV modes as independent data channels, we achieved the transmission of 32 Gbaud QPSK over 0.9 km ERCF without any multiple-input-multiple-output (MIMO) or polarization-division multiplexing (PDM) signal processing.

Validation of Mode-S Meteorological Routine Air Report aircraft observations

NASA Astrophysics Data System (ADS)

Strajnar, B.

2012-12-01

The success of mesoscale data assimilation depends on the availability of three-dimensional observations with high spatial and temporal resolution. This paper describes an example of such observations, available through Mode-S air traffic control system composed of ground radar and transponders on board the aircraft. The meteorological information is provided by interrogation of a dedicated meteorological data register, called Meteorological Routine Air Report (MRAR). MRAR provides direct measurements of temperature and wind, but is only returned by a small fraction of aircraft. The quality of Mode-S MRAR data, collected at the Ljubljana Airport, Slovenia, is assessed by its comparison with AMDAR and high-resolution radiosonde data sets, which enable high- and low-level validation, respectively. The need for temporal smoothing of raw Mode-S MRAR data is also studied. The standard deviation of differences between smoothed Mode-S MRAR and AMDAR is 0.35°C for temperature, 0.8 m/s for wind speed and below 10 degrees for wind direction. The differences with respect to radiosondes are larger, with standard deviations of approximately 1.7°C, 3 m/s and 25 degrees for temperature, wind speed and wind direction, respectively. It is concluded that both wind and temperature observations from Mode-S MRAR are accurate and therefore potentially very useful for data assimilation in numerical weather prediction models.

Pavement crack detection combining non-negative feature with fast LoG in complex scene

NASA Astrophysics Data System (ADS)

Wang, Wanli; Zhang, Xiuhua; Hong, Hanyu

2015-12-01

Pavement crack detection is affected by much interference in the realistic situation, such as the shadow, road sign, oil stain, salt and pepper noise etc. Due to these unfavorable factors, the exist crack detection methods are difficult to distinguish the crack from background correctly. How to extract crack information effectively is the key problem to the road crack detection system. To solve this problem, a novel method for pavement crack detection based on combining non-negative feature with fast LoG is proposed. The two key novelties and benefits of this new approach are that 1) using image pixel gray value compensation to acquisit uniform image, and 2) combining non-negative feature with fast LoG to extract crack information. The image preprocessing results demonstrate that the method is indeed able to homogenize the crack image with more accurately compared to existing methods. A large number of experimental results demonstrate the proposed approach can detect the crack regions more correctly compared with traditional methods.

Phase locking of a 1.5 Terahertz quantum cascade laser and use as a local oscillator in a heterodyne HEB receiver.

PubMed

Rabanus, D; Graf, U U; Philipp, M; Ricken, O; Stutzki, J; Vowinkel, B; Wiedner, M C; Walther, C; Fischer, M; Faist, J

2009-02-02

We demonstrate for the first time the closure of an electronic phase lock loop for a continuous-wave quantum cascade laser (QCL) at 1.5 THz. The QCL is operated in a closed cycle cryo cooler. We achieved a frequency stability of better than 100 Hz, limited by the resolution bandwidth of the spectrum analyser. The PLL electronics make use of the intermediate frequency (IF) obtained from a hot electron bolometer (HEB) which is downconverted to a PLL IF of 125 MHz. The coarse selection of the longitudinal mode and the fine tuning is achieved via the bias voltage of the QCL. Within a QCL cavity mode, the free-running QCL shows frequency fluctuations of about 5 MHz, which the PLL circuit is able to control via the Stark-shift of the QCL gain material. Temperature dependent tuning is shown to be nonlinear, and of the order of -16 MHz/K. Additionally we have used the QCL as local oscillator (LO) to pump an HEB and perform, again for the first time at 1.5 THz, a heterodyne experiment, and obtain a receiver noise temperature of 1741 K.

Orbital angular momentum mode groups multiplexing transmission over 2.6-km conventional multi-mode fiber.

PubMed

Zhu, Long; Wang, Andong; Chen, Shi; Liu, Jun; Mo, Qi; Du, Cheng; Wang, Jian

2017-10-16

Twisted light carrying orbital angular momentum (OAM) is a special kind of structured light that has a helical phase front, a phase singularity, and a doughnut intensity profile. Beyond widespread developments in manipulation, microscopy, metrology, astronomy, nonlinear and quantum optics, OAM-carrying twisted light has seen emerging application of optical communications in free space and specially designed fibers. Instead of specialty fibers, here we show the direct use of a conventional graded-index multi-mode fiber (MMF) for OAM communications. By exploiting fiber-compatible mode exciting and filtering elements, we excite the first four OAM mode groups in an MMF. We demonstrate 2.6-km MMF transmission using four data-carrying OAM mode groups (OAM 0,1 , OAM +1,1 /OAM -1,1 , OAM +2,1 , OAM +3,1 ). Moreover, we demonstrate two data-carrying OAM mode groups multiplexing transmission over the 2.6-km MMF with low-level crosstalk free of multiple-input multiple-output digital signal processing (MIMO-DSP). The demonstrations may open up new perspectives to fiber-based OAM communication/non-communication applications using already existing conventional fibers.

A new class of g-modes in neutron stars

NASA Technical Reports Server (NTRS)

Reisenegger, Andreas; Goldreich, Peter

1992-01-01

Because a neutron star is born hot, its internal composition is close to chemical equilibrium. In the fluid core, this implies that the ratio of the number densities of charged particles (protons and electrons) to neutrons is an increasing function of the mass density. This composition gradient stably stratifies the matter giving rise to a Brunt-Vaisala frequency N of about 500/s. Consequently, a neutron star core provides a cavity that supports gravity modes (g-modes). These g-modes are distinct from those previously identified with the thermal stratification of the surface layers and the chemical stratification of the crust. We compute the lowest-order, quadrupolar, g-modes for cold, Newtonian, neutron star models with M/solar M = 0.581 and M/solar M = 1.405, and show that the crustal and core g-modes have similar periods. We also discuss damping mechanisms and estimate damping rates for the core g-modes. Particular attention is paid to damping due to the emission of gravitational radiation.

Higgs boson gluon–fusion production at threshold in N 3LO QCD

DOE PAGES

Anastasiou, Charalampos; Duhr, Claude; Dulat, Falko; ...

2014-09-02

We present the cross-section for the threshold production of the Higgs boson at hadron-colliders at next-to-next-to-next-to-leading order (N 3LO) in perturbative QCD. Furthermore, we present an analytic expression for the partonic cross-section at threshold and the impact of these corrections on the numerical estimates for the hadronic cross-section at the LHC. With this result we achieve a major milestone towards a complete evaluation of the cross-section at N 3LO which will reduce the theoretical uncertainty in the determination of the strengths of the Higgs boson interactions.

Rice crop growth monitoring using ENVISAT-1/ASAR AP mode

NASA Astrophysics Data System (ADS)

Konishi, Tomohisa; Suga, Yuzo; Omatu, Shigeru; Takeuchi, Shoji; Asonuma, Kazuyoshi

2007-10-01

Hiroshima Institute of Technology (HIT) is operating the direct down-links of microwave and optical earth observation satellite data in Japan. This study focuses on the validation for rice crop monitoring using microwave remotely sensed image data acquired by ENIVISAT-1 referring to ground truth data such as height of rice crop, vegetation cover rate and leaf area index in the test sites of Hiroshima district, the western part of Japan. ENVISAT-1/ASAR data has the capabilities for the monitoring of the rice crop growing cycle by using alternating cross polarization mode images. However, ASAR data is influenced by several parameters such as land cover structure, direction and alignment of rice crop fields in the test sites. In this study, the validation was carried out to be combined with microwave image data and ground truth data regarding rice crop fields to investigate the above parameters. Multi-temporal, multi-direction (descending and ascending) and multi-angle ASAR alternating cross polarization mode images were used to investigate during the rice crop growing cycle. On the other hand, LANDSAT-7/ETM+ data were used to detect land cover structure, direction and alignment of rice crop fields corresponding to the backscatter of ASAR. Finally, the extraction of rice planted area was attempted by using multi-temporal ASAR AP mode data such as VV/VH and HH/HV. As the result of this study, it is clear that the estimated rice planted area coincides with the existing statistical data for area of the rice crop field. In addition, HH/HV is more effective than VV/VH in the rice planted area extraction.

Mode Conversion Behavior of Guided Wave in a Pipe Inspection System Based on a Long Waveguide.

PubMed

Sun, Feiran; Sun, Zhenguo; Chen, Qiang; Murayama, Riichi; Nishino, Hideo

2016-10-19

To make clear the mode conversion behavior of S0-mode lamb wave and SH0-plate wave converting to the longitudinal mode guided wave and torsional mode guided wave in a pipe, respectively, the experiments were performed based on a previous built pipe inspection system. The pipe was wound with an L-shaped plate or a T-shaped plate as the waveguide, and the S0-wave and SH0-wave were excited separately in the waveguide. To carry out the objective, a meander-line coil electromagnetic acoustic transducer (EMAT) for S0-wave and a periodic permanent magnet (PPM) EMAT for SH0-wave were developed and optimized. Then, several comparison experiments were conducted to compare the efficiency of mode conversion. Experimental results showed that the T(0,1) mode, L(0,1) mode, and L(0,2) mode guided waves can be successfully detected when converted from the S0-wave or SH0-wave with different shaped waveguides. It can also be inferred that the S0-wave has a better ability to convert to the T(0,1) mode, while the SH0-wave is easier to convert to the L(0,1) mode and L(0,2) mode, and the L-shaped waveguide has a better efficiency than T-shaped waveguide.

[Effects of HiLo for two weeks on erythrocyte immune adhesion and leukocyte count of swimmers].

PubMed

Zhao, Yong-Cai; Gao, Bing-Hong; Wu, Ge-Lin; Zhang, Jiu-Li

2012-07-01

To investigate the effects of living high-training low (HiLo) on innate immunity in blood of elite swimmers. Six female swimmers undertook HiLo for two weeks, erythrocyte adhesion function and counts of leukocyte were tested in different time of training period. Red blood cell C3b receptor ring rate (RBC-C3bRR) decreased and red blood cell immune complex matter ring rate (RBC-ICR) increased significantly (P < 0.05), the two markers returned to base line 1 week after training. Counts of leukocyte and granulocyte decreased significantly (P < 0.05), and they recovered 1 week after training; Counts of lymphocyte and monocyte decreased without significance during training and did not recovered after training. Immunity of erythrocyte and granulocyte decreased quickly, but lymphocyte and monocyte recovered slowly, swimmers were adaptive to the training.

Boson mode, Medium Range Structure and Intermediate Phase (IP) in (Na2O)x(B2O3)1-x glasses

NASA Astrophysics Data System (ADS)

Vignarooban, K.; Boolchand, P.; Micoulaut, M.; Malki, M.

2012-02-01

Raman scattering of titled glasses are examined using a T64000 Dispersive system. Scattering strengths of the Boson mode (40 cm-1, 70 cm-1) and the Boroxyl ring (BR) mode (808 cm-1) are found to decrease with increasing x at the same rate in the 0 < x < 20% soda range. Apparently, the 2D character of BRs embedded in a 3D network gives rise to the Boson mode.ootnotetextM. Flores-Ruiz and G. Naumis, PRB, 2011. 83: p. 184204 The triad of modes (705, 740, 770 cm-1) near the 808 cm-1 mode are found to display a maximum in scattering strength near x = 37% (705 cm-1), 33% (740 cm-1) and 25% (770 cm-1), suggesting that these are also ring modes of Na-tripentaborate (STPB), Na-diborate (SDB) and Na-triborate (STB) super-structures. Variations in Raman scattering strengths also suggest that STB percolate near x = 20%, the stress transition, while the STPB and SDTB percolate near x = 40%, the rigidity transition. These transitions were inferred from m-DSC experiments that show an intermediate phase in the 20% < x < 40% range in dry and homogeneous glasses.

A new method to real-normalize measured complex modes

NASA Technical Reports Server (NTRS)

Wei, Max L.; Allemang, Randall J.; Zhang, Qiang; Brown, David L.

1987-01-01

A time domain subspace iteration technique is presented to compute a set of normal modes from the measured complex modes. By using the proposed method, a large number of physical coordinates are reduced to a smaller number of model or principal coordinates. Subspace free decay time responses are computed using properly scaled complex modal vectors. Companion matrix for the general case of nonproportional damping is then derived in the selected vector subspace. Subspace normal modes are obtained through eigenvalue solution of the (M sub N) sup -1 (K sub N) matrix and transformed back to the physical coordinates to get a set of normal modes. A numerical example is presented to demonstrate the outlined theory.

Comparison of the lowest-order transverse-electric (TE1) and transverse-magnetic (TEM) modes of the parallel-plate waveguide for terahertz pulse applications.

PubMed

Mendis, Rajind; Mittleman, Daniel M

2009-08-17

We present a comprehensive experimental study comparing the propagation characteristics of the virtually unknown TE(1) mode to the well-known TEM mode of the parallel-plate waveguide (PPWG), for THz pulse applications. We demonstrate that it is possible to overcome the undesirable effects caused by the TE(1) mode's inherent low-frequency cutoff, making it a viable THz wave-guiding option, and that for certain applications, the TE(1) mode may even be more desirable than the TEM mode. This study presents a whole new dimension to the THz technological capabilities offered by the PPWG, via the possible use of the TE(1) mode. (c) 2009 Optical Society of America

Axisymmetric inertial modes in a spherical shell at low Ekman numbers

NASA Astrophysics Data System (ADS)

Rieutord, M.; Valdettaro, L.

2018-06-01

We investigate the asymptotic properties of axisymmetric inertial modes propagating in a spherical shell when viscosity tends to zero. We identify three kinds of eigenmodes whose eigenvalues follow very different laws as the Ekman number $E$ becomes very small. First are modes associated with attractors of characteristics that are made of thin shear layers closely following the periodic orbit traced by the characteristic attractor. Second are modes made of shear layers that connect the critical latitude singularities of the two hemispheres of the inner boundary of the spherical shell. Third are quasi-regular modes associated with the frequency of neutral periodic orbits of characteristics. We thoroughly analyse a subset of attractor modes for which numerical solutions point to an asymptotic law governing the eigenvalues. We show that three length scales proportional to $E^{1/6}$, $E^{1/4}$ and $E^{1/3}$ control the shape of the shear layers that are associated with these modes. These scales point out the key role of the small parameter $E^{1/12}$ in these oscillatory flows. With a simplified model of the viscous Poincar\\'e equation, we can give an approximate analytical formula that reproduces the velocity field in such shear layers. Finally, we also present an analysis of the quasi-regular modes whose frequencies are close to $\\sin(\\pi/4)$ and explain why a fluid inside a spherical shell cannot respond to any periodic forcing at this frequency when viscosity vanishes.

CC2 oscillator strengths within the local framework for calculating excitation energies (LoFEx).

PubMed

Baudin, Pablo; Kjærgaard, Thomas; Kristensen, Kasper

2017-04-14

In a recent work [P. Baudin and K. Kristensen, J. Chem. Phys. 144, 224106 (2016)], we introduced a local framework for calculating excitation energies (LoFEx), based on second-order approximated coupled cluster (CC2) linear-response theory. LoFEx is a black-box method in which a reduced excitation orbital space (XOS) is optimized to provide coupled cluster (CC) excitation energies at a reduced computational cost. In this article, we present an extension of the LoFEx algorithm to the calculation of CC2 oscillator strengths. Two different strategies are suggested, in which the size of the XOS is determined based on the excitation energy or the oscillator strength of the targeted transitions. The two strategies are applied to a set of medium-sized organic molecules in order to assess both the accuracy and the computational cost of the methods. The results show that CC2 excitation energies and oscillator strengths can be calculated at a reduced computational cost, provided that the targeted transitions are local compared to the size of the molecule. To illustrate the potential of LoFEx for large molecules, both strategies have been successfully applied to the lowest transition of the bivalirudin molecule (4255 basis functions) and compared with time-dependent density functional theory.

Normal Modes of a Lagrangian System Constrained in a Potential Well.

DTIC Science & Technology

1983-12-01

A’ -137 948 NORMAL MODES OF A LFHbRANGIAN SYSTEM CONSTRAINED INvi P0TENTIAL WELL(U WISCONSNN UNIV-MADISON MATHEMATICS RESEARCH CENTER V EN DEC F1...Carolina 27709 DT FLE OP Y UNIVERSITY OF WISCONSIN-MADISON MATHEMATICS RESEARCH CENTER NORMAL MODES OF A LAGRANGIAN SYSTEM CONSTRAINED IN A POTENTIAL WELL...respect to the norm lYE [f i + 2 yi )dtl/ 0 Since H I(S’ 1 n’) C CO(S, fle ), then the set A 1 0 is an open set in H1 (lf’) The periodic solution of

Numerical Investigation of LO2 and LCH4 Storage Tanks on the Lunar Surface

NASA Technical Reports Server (NTRS)

Moder, Jeff; Barsi, Stephen; Kassemi, Mohammad

2008-01-01

Currently NASA is developing technologies to enable human exploration of the lunar surface for duration of up to 210 days. While trade studies are still underway, a cryogenic ascent stage using liquid oxygen (LO2) and liquid methane (LCH4) is being considered for the Altair lunar lander. For a representative Altair cryogenic ascent stage, we present a detailed storage analysis of the LO2 and LCH4 propellant tanks on the lunar surface for durations of up to 210 days. Both the LO2 and LCH4 propellant tanks are assumed to be pressurized with gaseous helium at launch. A two-phase lumped-vapor computational fluid dynamics model has been developed to account for the presence of a noncondensable gas in the ullage. The CFD model is used to simulate the initial pressure response of the propellant tanks while they are subjected to representative heat leak rates on the lunar surface. Once a near stationary state is achieved within the liquid phase, multizone model is used to extrapolate the solution farther in time. For fixed propellant mass and tank size, the long-term pressure response for different helium mass fractions in both the LO2 and LCH4 tanks is examined.

The inhibition of 5-Lipoxygenase (5-LO) products leukotriene B4 (LTB4) and cysteinyl leukotrienes (cysLTs) modulates the inflammatory response and improves cutaneous wound healing.

PubMed

Guimarães, Francielle Rodrigues; Sales-Campos, Helioswilton; Nardini, Viviani; da Costa, Thiago Alvares; Fonseca, Monique Thaís Costa; Júnior, Virmondes Rodrigues; Sorgi, Carlos Artério; da Silva, João Santana; Chica, Javier Emílio Lazo; Faccioli, Lúcia Helena; de Barros Cardoso, Cristina Ribeiro

2018-05-01

To analyze the participation of the enzyme 5-lipoxygenase (5-LO) in skin repair, WT wounds were compared to those in 5-LO deficient mice (5-LO -/- ), which presented faster closure and reduced inflammatory infiltrate in the skin, together with increased CD4 regulatory T cells markers in the draining lymph nodes. The 5-LO -/- wounds also had diminished TNF-α, CCL11, CCL7, CCL2, CXCL9, CCR1 and CXCR2 mRNA expression in the lesions, besides differential extracellular matrix remodeling. Furthermore, when cysteinyl leukotriene (cysLT) and leukotriene (LTB 4 ) receptors were antagonized in WT mice, there was a remarkable reduction in TNF-α expression and faster skin healing, similarly to the findings in 5-LO -/- animals. Finally, our results suggested that 5-LO products, in special cysLT and LTB 4 , underline skin inflammation that follows skin injury and their neutralization may be an important strategy to improve cutaneous healing. Copyright © 2017 Elsevier Inc. All rights reserved.

ToF-SIMS Depth Profiling Of Insulating Samples, Interlaced Mode Or Non-interlaced Mode?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Zhaoying; Jin, Ke; Zhang, Yanwen

2014-11-01

Dual beam depth profiling strategy has been widely adopted in ToF-SIMS depth profiling, in which two basic operation modes, interlaced mode and non-interlaced mode, are commonly used. Generally, interlaced mode is recommended for conductive or semi-conductive samples, whereas non-interlaced mode is recommended for insulating samples, where charge compensation can be an issue. Recent publications, however, show that the interlaced mode can be used effectively for glass depth profiling, despite the fact that glass is an insulator. In this study, we provide a simple guide for choosing between interlaced mode and non-interlaced mode for insulator depth profiling. Two representative cases aremore » presented: (1) depth profiling of a leached glass sample, and (2) depth profiling of a single crystal MgO sample. In brief, the interlaced mode should be attempted first, because (1) it may provide reasonable-quality data, and (2) it is time-saving for most cases, and (3) it introduces low H/C/O background. If data quality is the top priority and measurement time is flexible, non-interlaced mode is recommended because interlaced mode may suffer from low signal intensity and poor mass resolution. A big challenge is tracking trace H/C/O in a highly insulating sample (e.g., MgO), because non-interlaced mode may introduce strong H/C/O background but interlaced mode may suffer from low signal intensity. Meanwhile, a C or Au coating is found to be very effective to improve the signal intensity. Surprisingly, the best analyzing location is not on the C or Au coating, but at the edge (outside) of the coating.« less

Single-Shot Optical Sectioning Using Two-Color Probes in HiLo Fluorescence Microscopy

PubMed Central

Muro, Eleonora; Vermeulen, Pierre; Ioannou, Andriani; Skourides, Paris; Dubertret, Benoit; Fragola, Alexandra; Loriette, Vincent

2011-01-01

We describe a wide-field fluorescence microscope setup which combines HiLo microscopy technique with the use of a two-color fluorescent probe. It allows one-shot fluorescence optical sectioning of thick biological moving sample which is illuminated simultaneously with a flat and a structured pattern at two different wavelengths. Both homogenous and structured fluorescence images are spectrally separated at detection and combined similarly with the HiLo microscopy technique. We present optically sectioned full-field images of Xenopus laevis embryos acquired at 25 images/s frame rate. PMID:21641327

Few-Mode Whispering-Gallery-Mode Resonators

NASA Technical Reports Server (NTRS)

Savchenkov, Anatoliy; Strekalov, Dmitry; Matsko, Andrey; Iltchenko, Vladimir; Maleki, Lute

2006-01-01

Whispering-gallery-mode (WGM) optical resonators of a type now under development are designed to support few well-defined waveguide modes. In the simplest case, a resonator of this type would support one equatorial family of WGMs; in a more complex case, such a resonator would be made to support two, three, or some other specified finite number of modes. Such a resonator can be made of almost any transparent material commonly used in optics. The nature of the supported modes does not depend on which material is used, and the geometrical dispersion of this resonator is much smaller than that of a typical prior WGM resonator. Moreover, in principle, many such resonators could be fabricated as integral parts of a single chip. Basically, a resonator of this type consists of a rod, made of a suitable transparent material, from which protrudes a thin circumferential belt of the same material. The belt is integral with the rest of the rod (see figure) and acts as a circumferential waveguide. If the depth (d) and width (w) of the belt are made appropriately small, then the belt acts as though it were the core of a single-mode optical fiber: the belt and its adjacent supporting rod material support a single, circumferentially propagating mode or family of modes. It has been shown theoretically that the fiber-optic-like behavior of the belton- rod resonator structure can be summarized, in part, by the difference, Dn, between (1) an effective index of refraction of an imaginary fiber core and (2) the index of refraction (n) of the transparent rod/belt material. It has also been shown theoretically that for a given required value of Dn, the required depth of the belt can be estimated as d R Dn, where R is the radius of the rod. It must be emphasized that this estimated depth is independent of n and, hence, is independent of the choice of rod material. As in the cases of prior WGM resonators, input/output optical coupling involves utilization of evanescent fields. In the

Bayesian estimation of Karhunen–Loève expansions; A random subspace approach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chowdhary, Kenny; Najm, Habib N.

One of the most widely-used statistical procedures for dimensionality reduction of high dimensional random fields is Principal Component Analysis (PCA), which is based on the Karhunen-Lo eve expansion (KLE) of a stochastic process with finite variance. The KLE is analogous to a Fourier series expansion for a random process, where the goal is to find an orthogonal transformation for the data such that the projection of the data onto this orthogonal subspace is optimal in the L 2 sense, i.e, which minimizes the mean square error. In practice, this orthogonal transformation is determined by performing an SVD (Singular Value Decomposition)more » on the sample covariance matrix or on the data matrix itself. Sampling error is typically ignored when quantifying the principal components, or, equivalently, basis functions of the KLE. Furthermore, it is exacerbated when the sample size is much smaller than the dimension of the random field. In this paper, we introduce a Bayesian KLE procedure, allowing one to obtain a probabilistic model on the principal components, which can account for inaccuracies due to limited sample size. The probabilistic model is built via Bayesian inference, from which the posterior becomes the matrix Bingham density over the space of orthonormal matrices. We use a modified Gibbs sampling procedure to sample on this space and then build a probabilistic Karhunen-Lo eve expansions over random subspaces to obtain a set of low-dimensional surrogates of the stochastic process. We illustrate this probabilistic procedure with a finite dimensional stochastic process inspired by Brownian motion.« less

Bayesian estimation of Karhunen–Loève expansions; A random subspace approach

DOE PAGES

Chowdhary, Kenny; Najm, Habib N.

2016-04-13

One of the most widely-used statistical procedures for dimensionality reduction of high dimensional random fields is Principal Component Analysis (PCA), which is based on the Karhunen-Lo eve expansion (KLE) of a stochastic process with finite variance. The KLE is analogous to a Fourier series expansion for a random process, where the goal is to find an orthogonal transformation for the data such that the projection of the data onto this orthogonal subspace is optimal in the L 2 sense, i.e, which minimizes the mean square error. In practice, this orthogonal transformation is determined by performing an SVD (Singular Value Decomposition)more » on the sample covariance matrix or on the data matrix itself. Sampling error is typically ignored when quantifying the principal components, or, equivalently, basis functions of the KLE. Furthermore, it is exacerbated when the sample size is much smaller than the dimension of the random field. In this paper, we introduce a Bayesian KLE procedure, allowing one to obtain a probabilistic model on the principal components, which can account for inaccuracies due to limited sample size. The probabilistic model is built via Bayesian inference, from which the posterior becomes the matrix Bingham density over the space of orthonormal matrices. We use a modified Gibbs sampling procedure to sample on this space and then build a probabilistic Karhunen-Lo eve expansions over random subspaces to obtain a set of low-dimensional surrogates of the stochastic process. We illustrate this probabilistic procedure with a finite dimensional stochastic process inspired by Brownian motion.« less

Passively mode-locked diode-pumped Tm3+:YLF laser emitting at 1.91 µm using a GaAs-based SESAM

NASA Astrophysics Data System (ADS)

Tyazhev, A.; Soulard, R.; Godin, T.; Paris, M.; Brasse, G.; Doualan, J.-L.; Braud, A.; Moncorgé, R.; Laroche, M.; Camy, P.; Hideur, A.

2018-04-01

We report on a diode-pumped Tm:YLF laser passively mode-locked with an InGaAs saturable absorber. The laser emits a train of 31 ps pulses at a wavelength of 1.91 µm with a repetition rate of 94 MHz and a maximum average power of 95 mW. A sustained and robust mode-locking with a signal-to-noise ratio of ~70 dB is obtained even at high relative air humidity, making this system attractive for applications requiring ultra-short pulses in the spectral window just below 2 µm.

Linking structure and vibrational mode coupling using high-resolution infrared spectroscopy: A comparison of gauche and trans 1-chloro-2-fluoroethane

NASA Astrophysics Data System (ADS)

Miller, C. Cameron; Stone, Stephen C.; Philips, Laura A.

1995-01-01

The high-resolution infrared spectrum of 1-chloro-2-fluoroethane in a molecular beam was collected over the 2975-2994 cm-1 spectral region. The spectral region of 2975-2981 cm-1 contains a symmetric C-H stretching vibrational band of the gauche conformer containing the 35Cl isotope. The spectral region of 2985-2994 cm-1 contains three vibrational bands of the trans conformer. Two of the three bands are assigned as an antisymmetric C-H stretch of each of the two different chlorine isotopes. The third band is assigned as a symmetric C-H stretch of the 35Cl isotope. The gauche conformer of 1-chloro-2-fluoroethane showed doublet patterns similar to those previously observed in 1,2-difluoroethane. The model for 1,2-difluoroethane is further refined in the present work. These refinements suggest that the coupling dark state in 1,2-difluoroethane is composed of 1 quantum C-H bend, 1 quantum C-C stretch, and 12 quanta of torsion. For 1-chloro-2-fluoroethane the dark state could not be identified due to a small data set. The trans conformer of 1-chloro-2-fluoroethane showed no evidence of mode coupling in the three vibrational bands. Including 2-fluoroethanol in this series of molecules, the extent of vibrational mode coupling did not correlate with the density of states available for coupling. Therefore, density of states alone is insufficient to explain the observed trend. A correlation was observed between the degree of intramolecular interaction and vibrational mode coupling.

Extension of Pressure Measurement to 6× 10-11 Torr Using the Dynamics of the m=1 Diocotron Mode*

NASA Astrophysics Data System (ADS)

Paul, Stephen F.; Morrison, Kyle; Davidson, Ronald C.; Jenkins, Thomas

2001-10-01

Damping of the m=1 diocotron mode is used to measure neutral pressure in the Electron Diffusion Gauge (EDG). The drag exerted on the rotating plasma by collisions with neutrals is expected to excite the mode. However, previous studies in the EDG showed that the diocotron mode is more strongly damped at higher neutral pressures. The damping scaled as P-1/2 in the range from 5× 10-10 to 2× 10-7 Torr. This range has been extended from 6× 10-11 to 5× 10-7 Torr. Above 10-7 Torr, the damping increases linearly with P. Below 5× 10-9 Torr, the scaling is less sensitive, ≈ P-1/4, exhibiting a smooth transition. Sensitivity to pressure increments of less than ΔP = 1× 10-10 Torr are observed. Mode damping is correlated with the rate of expansion of the plasma, which occurs simultaneously. At high pressure, collisions with neutrals dominate the expansion, resulting in a similarly sensitive dependence on pressure. At low pressure, device asymmetries dominate the plasma expansion. Whereas plasma expansion is virtually insensitive to pressures below 5× 10-8 Torr, diocotron mode measurements have shown sensitivity over two orders of magnitude lower in pressure. Both diocotron mode damping and plasma expansion also depend similarly on electron density and magnetic field. Conditions that favor expansion (low field, high collisionality) also favor mode damping. *Research supported by the Office of Naval Research

Hydrogeology and analysis of ground-water withdrawal in the Mendenhall-D'Lo area, Simpson County, Mississippi

USGS Publications Warehouse

Strom, E.W.; Oakley, W.T.

1995-01-01

The cities of Mendenhall and D'Lo, located in Simpson County, rely on ground water for their public supply and industrial needs. Most of the ground water comes from an aquifer of Miocene age. A study began in 1991 to describe the hydrogeology, analyze effects of ground-water withdrawal by making a drawdown map, and estimate the effects increased ground-water withdrawal might have on water levels in the Miocene age aquifer in the Mendenhall-D'Lo area. The most significant withdrawals of ground water in the study area are from 10 wells screened in the lower sand of the Catahoula Formation of Miocene age. Analysis of the effect of withdrawals from the 10 wells was made using the Theis non- equilibrium equation and applying the principle of superposition. Analysis of 1994 conditions was based on the pumpage history and aquifer properties deter- mined for each well. The drawdown surface resulting from the analysis indicates three general cones of depression. One cone is in the northwestern D'Lo area, one in the south-central Mendenhall area, and one about 1-1/2 miles east of Mendenhall. Calculated drawdown ranges from 21 to 47 feet. Potential drawdown-surface maps were made for 10 years and 20 years beyond 1994 using a constant pumpage. The map made for 10 years beyond 1994 indicates an average total increase in drawdown of about 5.3 feet. The map made for 20 years beyond 1994 indicates an average total increase in drawdown of about 7.3 feet.

Balmer Absorption Lines in FeLoBALs

NASA Astrophysics Data System (ADS)

Aoki, K.; Iwata, I.; Ohta, K.; Tamura, N.; Ando, M.; Akiyama, M.; Kiuchi, G.; Nakanishi, K.

2007-10-01

We discovered non-stellar Balmer absorption lines in two many-narrow-trough FeLoBALs (mntBALs) by the near-infrared spectroscopy with Subaru/CISCO. Presence of the non-stellar Balmer absorption lines is known to date only in the Seyfert galaxy NGC 4151; thus our discovery is the first cases for quasars. Since all known active galactic nuclei with Balmer absorption lines share similar characteristics, it is suggested that there is a population of BAL quasars which have unique structures at their nuclei or unique evolutionary phase.

The LO Model and the Traditional French Organisational Culture: A Paradigmatic Contradiction Leading to a Limited Implementation

ERIC Educational Resources Information Center

Belet, Daniel

2010-01-01

This article deals with the issue of the very weak implementation of the LO model in France, although it appears as an appealing new management paradigm that can allow companies to better face a fast changing environment. The author argues that there is a strong philosophical contradiction between this innovative management model and the still…

Finite-Length Diocotron Modes in a Non-neutral Plasma Column

NASA Astrophysics Data System (ADS)

Walsh, Daniel; Dubin, Daniel

2017-10-01

Diocotron modes are 2D distortions of a non-neutral plasma column that propagate azimuthally via E × B drifts. While the infinite-length theory of diocotron modes is well-understood for arbitrary azimuthal mode number l, the finite-length mode frequency is less developed (with some exceptions), and is naturally of relevance to experiments. In this poster, we present an approach to address finite length effects, such as temperature dependence of the mode frequency. We use a bounce-averaged solution to the Vlasov Equation, in which the Vlasov Equation is solved using action-angle variables of the unperturbed Hamiltonian. We write the distribution function as a Fourier series in the bounce-angle variable ψ, keeping only the bounce-averaged term. We demonstrate a numerical solution to this equation for a realistic plasma with a finite Debye Length, compare to the existing l = 1 theory, and discuss possible extensions of the existing theory to l ≠ 1 . Supported by NSF/DOE Partnership Grants PHY1414570 and DESC0002451.

Temperature dependence of the LO phonon sidebands in free exciton emission of GaN