8 CFR 204.310 - Filing requirements for Form I-800A.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Filing requirements for Form I-800A. 204.310 Section 204.310 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS... evidence that the other spouse, if he or she lives in the United States, is either a non-citizen United...

8 CFR 204.5 - Petitions for employment-based immigrants.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Petitions for employment-based immigrants. 204.5 Section 204.5 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS.... A petition to classify an alien under section 203(b)(1), 203(b)(2), or 203(b)(3) of the Act must be...

30 CFR 204.203 - What is the other relief option?

Code of Federal Regulations, 2010 CFR

2010-07-01

... MANAGEMENT ALTERNATIVES FOR MARGINAL PROPERTIES Accounting and Auditing Relief § 204.203 What is the other relief option? (a) Under this relief option, you may request any type of accounting and auditing relief...

50 CFR 222.203 - Modification, amendment, suspension, and revocation of certificates.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS GENERAL ENDANGERED AND THREATENED MARINE SPECIES Certificates of Exemption for Pre-Act Endangered Species Parts § 222.203...

50 CFR 222.203 - Modification, amendment, suspension, and revocation of certificates.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS GENERAL ENDANGERED AND THREATENED MARINE SPECIES Certificates of Exemption for Pre-Act Endangered Species Parts § 222.203...

50 CFR 222.203 - Modification, amendment, suspension, and revocation of certificates.

Code of Federal Regulations, 2013 CFR

2013-10-01

..., NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS GENERAL ENDANGERED AND THREATENED MARINE SPECIES Certificates of Exemption for Pre-Act Endangered Species Parts § 222.203...

50 CFR 222.203 - Modification, amendment, suspension, and revocation of certificates.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS GENERAL ENDANGERED AND THREATENED MARINE SPECIES Certificates of Exemption for Pre-Act Endangered Species Parts § 222.203...

50 CFR 222.203 - Modification, amendment, suspension, and revocation of certificates.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS GENERAL ENDANGERED AND THREATENED MARINE SPECIES Certificates of Exemption for Pre-Act Endangered Species Parts § 222.203...

50 CFR 222.204 - Administration of certificates.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Certificates of Exemption for Pre-Act Endangered Species Parts § 222.204 Administration of certificates. (a... warehouse facility used by the certificate holder solely for storage of pre-Act endangered species parts, if... documents and any endangered species parts. (f) The records pertaining to pre-Act endangered species parts...

50 CFR 222.204 - Administration of certificates.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Certificates of Exemption for Pre-Act Endangered Species Parts § 222.204 Administration of certificates. (a... warehouse facility used by the certificate holder solely for storage of pre-Act endangered species parts, if... documents and any endangered species parts. (f) The records pertaining to pre-Act endangered species parts...

50 CFR 222.204 - Administration of certificates.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Certificates of Exemption for Pre-Act Endangered Species Parts § 222.204 Administration of certificates. (a... warehouse facility used by the certificate holder solely for storage of pre-Act endangered species parts, if... documents and any endangered species parts. (f) The records pertaining to pre-Act endangered species parts...

50 CFR 222.204 - Administration of certificates.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Certificates of Exemption for Pre-Act Endangered Species Parts § 222.204 Administration of certificates. (a... warehouse facility used by the certificate holder solely for storage of pre-Act endangered species parts, if... documents and any endangered species parts. (f) The records pertaining to pre-Act endangered species parts...

50 CFR 222.204 - Administration of certificates.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Certificates of Exemption for Pre-Act Endangered Species Parts § 222.204 Administration of certificates. (a... warehouse facility used by the certificate holder solely for storage of pre-Act endangered species parts, if... documents and any endangered species parts. (f) The records pertaining to pre-Act endangered species parts...

Hanford Tanks 241-C-203 and 241-C-204: Residual Waste Contaminant Release Model and Supporting Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deutsch, William J.; Krupka, Kenneth M.; Lindberg, Michael J.

This report describes the development of release models for key contaminants that are present in residual sludge remaining after closure of Hanford Tanks 241-C-203 (C-203) and 241-C-204 (C-204). The release models were developed from data generated by laboratory characterization and testing of samples from these two tanks. Key results from this work are (1) future releases from the tanks of the primary contaminants of concern (99Tc and 238U) can be represented by relatively simple solubility relationships between infiltrating water and solid phases containing the contaminants; and (2) high percentages of technetium-99 in the sludges (20 wt% in C-203 and 75more » wt% in C-204) are not readily water leachable, and, in fact, are very recalcitrant. This is similar to results found in related studies of sludges from Tank AY-102. These release models are being developed to support the tank closure risk assessments performed by CH2M HILL Hanford Group, Inc., for the U.S. Department of Energy.« less

48 CFR 1.106 - OMB approval under the Paperwork Reduction Act.

Code of Federal Regulations, 2010 CFR

2010-10-01

...-0134 52.223-5 9000-0147 52.223-6(b)(5) 9000-0101 52.223-9 9000-0134 52.223-13 9000-0139 52.223-14 9000... 9000-0027 49 9000-0028 50 9000-0029 51.1 9000-0031 51.2 9000-0032 52.203-2 9000-0018 52.203-7 9000-0091 52.204-3 9000-0097 52.204-6 9000-0145 52.204-7 9000-0159 52.207-3 9000-0114 52.211-8 9000-0043 52.211...

22 CFR 20.4 - Retirement benefits.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Retirement benefits. 20.4 Section 20.4 Foreign Relations DEPARTMENT OF STATE PERSONNEL BENEFITS FOR CERTAIN FORMER SPOUSES § 20.4 Retirement benefits. (a) Type of benefits. (1) A former spouse who meets the qualification requirements of § 20.3 is entitled to...

22 CFR 20.4 - Retirement benefits.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Retirement benefits. 20.4 Section 20.4 Foreign Relations DEPARTMENT OF STATE PERSONNEL BENEFITS FOR CERTAIN FORMER SPOUSES § 20.4 Retirement benefits. (a) Type of benefits. (1) A former spouse who meets the qualification requirements of § 20.3 is entitled to...

22 CFR 20.4 - Retirement benefits.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Retirement benefits. 20.4 Section 20.4 Foreign Relations DEPARTMENT OF STATE PERSONNEL BENEFITS FOR CERTAIN FORMER SPOUSES § 20.4 Retirement benefits. (a) Type of benefits. (1) A former spouse who meets the qualification requirements of § 20.3 is entitled to...

22 CFR 20.4 - Retirement benefits.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Retirement benefits. 20.4 Section 20.4 Foreign Relations DEPARTMENT OF STATE PERSONNEL BENEFITS FOR CERTAIN FORMER SPOUSES § 20.4 Retirement benefits. (a) Type of benefits. (1) A former spouse who meets the qualification requirements of § 20.3 is entitled to...

22 CFR 20.4 - Retirement benefits.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Retirement benefits. 20.4 Section 20.4 Foreign Relations DEPARTMENT OF STATE PERSONNEL BENEFITS FOR CERTAIN FORMER SPOUSES § 20.4 Retirement benefits. (a) Type of benefits. (1) A former spouse who meets the qualification requirements of § 20.3 is entitled to...

Student Flow Simulation for the Consolidated Navy Electronic Warfare School.

DTIC Science & Technology

1982-07-01

WLR-1 201 202 203 204 205 USN 6YO AN/SLQ-32 206 207 208 209 210 USN 6YO AN/SLQ-17 211 212 213 214 215 JSN 6YO AN/WLR-8 216 217 218 219 220 uSN 4YO AN...WLR-I 221 222 2?3 224 225 JSN 4YO AN/SLQ-32 226 227 228 229 230 UrN 4YO AN/SLQ-17 231 232 233 234 235 USN 4YO AN/WLR-8 236 237 238 2 9 240 JSN 3X6 AN...USN 6YO 1 ASSIGN node ASS3 (after CDP 3C) USN 4YO 2 GOON node N3 USN 3X6 3 GOON node N3 USN Late Conv. 4 GOON node N3 Fit. Returnee 6 Introduced in the

48 CFR 2903.204 - Treatment of violations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Treatment of violations. 2903.204 Section 2903.204 Federal Acquisition Regulations System DEPARTMENT OF LABOR GENERAL IMPROPER....204 Treatment of violations. Any suspected violations of FAR subpart 3.2 and the clause at FAR 52.203...

48 CFR 13.006 - Inapplicable provisions and clauses.

Code of Federal Regulations, 2011 CFR

2011-10-01

... threshold: (a) 52.203-5, Covenant Against Contingent Fees. (b) 52.203-6, Restrictions on Subcontractor Sales to the Government. (c) 52.203-7, Anti-Kickback Procedures. (d) 52.215-2, Audits and Records... the American Recovery and Reinvestment Act of 2009 (Pub. L. 111-5). (e) 52.222-4, Contract Work Hours...

48 CFR 13.006 - Inapplicable provisions and clauses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... threshold: (a) 52.203-5, Covenant Against Contingent Fees. (b) 52.203-6, Restrictions on Subcontractor Sales to the Government. (c) 52.203-7, Anti-Kickback Procedures. (d) 52.215-2, Audits and Records... the American Recovery and Reinvestment Act of 2009 (Pub. L. 111-5). (e) 52.222-4, Contract Work Hours...

48 CFR 13.006 - Inapplicable provisions and clauses.

Code of Federal Regulations, 2013 CFR

2013-10-01

... threshold: (a) 52.203-5, Covenant Against Contingent Fees. (b) 52.203-6, Restrictions on Subcontractor Sales to the Government. (c) 52.203-7, Anti-Kickback Procedures. (d) 52.215-2, Audits and Records... the American Recovery and Reinvestment Act of 2009 (Pub. L. 111-5). (e) 52.222-4, Contract Work Hours...

48 CFR 13.006 - Inapplicable provisions and clauses.

Code of Federal Regulations, 2014 CFR

2014-10-01

... threshold: (a) 52.203-5, Covenant Against Contingent Fees. (b) 52.203-6, Restrictions on Subcontractor Sales to the Government. (c) 52.203-7, Anti-Kickback Procedures. (d) 52.215-2, Audits and Records... the American Recovery and Reinvestment Act of 2009 (Pub. L. 111-5). (e) 52.222-4, Contract Work Hours...

48 CFR 13.006 - Inapplicable provisions and clauses.

Code of Federal Regulations, 2012 CFR

2012-10-01

... threshold: (a) 52.203-5, Covenant Against Contingent Fees. (b) 52.203-6, Restrictions on Subcontractor Sales to the Government. (c) 52.203-7, Anti-Kickback Procedures. (d) 52.215-2, Audits and Records... the American Recovery and Reinvestment Act of 2009 (Pub. L. 111-5). (e) 52.222-4, Contract Work Hours...

Ft. Benning, Georgia. Revised Uniform Summary of Surface Weather Observations. Parts A-F.

DTIC Science & Technology

1987-09-01

92.4 GE 27001 1 . 2 93.4 94.6 4 4. 94 . .1 95.1 95.1 45. 1 95.1 95.1 95.1 95.1 95.1 95.1 GE 1801 91.6 94.2 96.1 95.4 j.4 ,.7 95.7 95.7 95.7 95.7 95.7...300 310 3651 0 ISO .191 .192 .204 .147 .110 .088 .073 .078 .103 .119 .151 .182 .153 1,01 oJsI 310 282 3P18 31 310 300 310 110 300 310 300 310 3650 ME~l

Los Angeles County Poor Farm, Patient Wards 201, 202, 203, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Los Angeles County Poor Farm, Patient Wards 201, 202, 203, 204, 205, 206, 207, 208 & 209 - Type A Plan, 7601 Imperial Highway; bounded by Esperanza Street, Hawthorn Avenue, Laurel Street, and Descanso Street, Downey, Los Angeles County, CA

77 FR 76936 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-31

...; List of Subjects in 48 CFR Parts 201, 203, 204, 215, 219, 245, and 252 Government procurement. Manuel... clause 52.203-13, Contractor Code of Business Ethics and Conduct, is the DoD Office of Inspector General...

5 CFR 9901.203 - Waivers.

Code of Federal Regulations, 2011 CFR

2011-01-01

... (NSPS) Classification General § 9901.203 Waivers. (a) When a specified category of employees is covered by a classification system established under this subpart, the provisions of 5 U.S.C. chapter 51 are..., §§ 9901.106, and 9901.222(d) (with respect to OPM's authority to act on requests for classification...

5 CFR 9901.203 - Waivers.

Code of Federal Regulations, 2010 CFR

2010-01-01

... (NSPS) Classification General § 9901.203 Waivers. (a) When a specified category of employees is covered by a classification system established under this subpart, the provisions of 5 U.S.C. chapter 51 are..., §§ 9901.106, and 9901.222(d) (with respect to OPM's authority to act on requests for classification...

Interior building details of Building C, Room C203 to Room ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Interior building details of Building C, Room C-203 to Room C-204: historical partition track with folding doors, east painted wall; easterly view - San Quentin State Prison, Building 22, Point San Quentin, San Quentin, Marin County, CA

40 CFR 61.203 - Radon monitoring and compliance procedures.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 8 2010-07-01 2010-07-01 false Radon monitoring and compliance... for Radon Emissions From Phosphogypsum Stacks § 61.203 Radon monitoring and compliance procedures. (a..., each owner or operator of an inactive phosphogypsum stack shall test the stack for radon-222 flux in...

40 CFR 61.203 - Radon monitoring and compliance procedures.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 8 2011-07-01 2011-07-01 false Radon monitoring and compliance... for Radon Emissions From Phosphogypsum Stacks § 61.203 Radon monitoring and compliance procedures. (a..., each owner or operator of an inactive phosphogypsum stack shall test the stack for radon-222 flux in...

24 CFR 203.204 - Requirements and limitations of a plan.

Code of Federal Regulations, 2013 CFR

2013-04-01

... claims covered under § 203.205. Warranties set forth in a Plan must comply with section 2301(a)(1)-(13... homeowner complaints covered by a Plan, including those regarding construction deficiencies and structural defects claims, will be settled in the amount of their actual cost to correct or for the original sales...

24 CFR 203.204 - Requirements and limitations of a plan.

Code of Federal Regulations, 2014 CFR

2014-04-01

... claims covered under § 203.205. Warranties set forth in a Plan must comply with section 2301(a)(1)-(13... homeowner complaints covered by a Plan, including those regarding construction deficiencies and structural defects claims, will be settled in the amount of their actual cost to correct or for the original sales...

24 CFR 203.204 - Requirements and limitations of a plan.

Code of Federal Regulations, 2010 CFR

2010-04-01

... claims covered under § 203.205. Warranties set forth in a Plan must comply with section 2301(a)(1)-(13... homeowner complaints covered by a Plan, including those regarding construction deficiencies and structural defects claims, will be settled in the amount of their actual cost to correct or for the original sales...

24 CFR 203.204 - Requirements and limitations of a plan.

Code of Federal Regulations, 2011 CFR

2011-04-01

... claims covered under § 203.205. Warranties set forth in a Plan must comply with section 2301(a)(1)-(13... homeowner complaints covered by a Plan, including those regarding construction deficiencies and structural defects claims, will be settled in the amount of their actual cost to correct or for the original sales...

24 CFR 203.204 - Requirements and limitations of a plan.

Code of Federal Regulations, 2012 CFR

2012-04-01

... claims covered under § 203.205. Warranties set forth in a Plan must comply with section 2301(a)(1)-(13... homeowner complaints covered by a Plan, including those regarding construction deficiencies and structural defects claims, will be settled in the amount of their actual cost to correct or for the original sales...

17 CFR 275.222-2 - Definition of “client” for purposes of the national de minimis standard.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 1940 § 275.222-2 Definition of “client” for purposes of the national de minimis standard. For purposes... definition of “client” provided by section 275.203(b)(3)-1 without giving regard to paragraph (b)(6) of that...

17 CFR 275.204-1 - Amendments to application for registration.

Code of Federal Regulations, 2010 CFR

2010-04-01

... you have received a continuing hardship exemption under § 275.203-3. (2) If you have received a... (CONTINUED) RULES AND REGULATIONS, INVESTMENT ADVISERS ACT OF 1940 § 275.204-1 Amendments to application for... a complete Part 1A of Form ADV on paper with the SEC by mailing it to FINRA. (c) Special rule for...

UMAP Modules-Units 203-211, 215-216, 231-232.

ERIC Educational Resources Information Center

Schoenfeld, Alan H.; And Others

One module is presented in units 203, 204, and 205, as a guide for students, and presents a general strategy for solving integrals effectively. With this material is a solutions manual to exercises. This document set also includes a unit featuring applications of calculus to geography: 206-Mercator's World Map and the Calculus. Unit 207-Management…

Structural basis for a hand-like site in the calcium sensor CatchER with fast kinetics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Ying; Reddish, Florence; Tang, Shen

2013-12-01

High-resolution crystal structures of the designed calcium sensor CatchER revealed snapshots of calcium and gadolinium ions binding within the designed site in agreement with its fast kinetics. Calcium ions, which are important signaling molecules, can be detected in the endoplasmic reticulum by an engineered mutant of green fluorescent protein (GFP) designated CatchER with a fast off-rate. High resolution (1.78–1.20 Å) crystal structures were analyzed for CatchER in the apo form and in complexes with calcium or gadolinium to probe the binding site for metal ions. While CatchER exhibits a 1:1 binding stoichiometry in solution, two positions were observed for eachmore » of the metal ions bound within the hand-like site formed by the carboxylate side chains of the mutated residues S147E, S202D, Q204E, F223E and T225E that may be responsible for its fast kinetic properties. Comparison of the structures of CatchER, wild-type GFP and enhanced GFP confirmed that different conformations of Thr203 and Glu222 are associated with the two forms of Tyr66 of the chromophore which are responsible for the absorbance wavelengths of the different proteins. Calcium binding to CatchER may shift the equilibrium for conformational population of the Glu222 side chain and lead to further changes in its optical properties.« less

76 FR 30337 - Combined Notice of Filings No. 1

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-25

...: Texas Eastern Transmission, LP submits tariff filing per 154.203: Hot Spring Lateral Recourse Rates... 154.203: Hot Spring Lateral Agreements--CP10-471 Compliance to be effective 6/1/2011. Filed Date: 05...: Ozark Gas Transmission, L.L.C. submits tariff filing per 154.204: KGen Hot Spring Agreements to be...

76 FR 9868 - Office of Hazardous Materials Safety; Notice of Application for Special Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-22

... 15213-N Centronic LLC, 49 CFR 172.101 Column 9 To authorize the Houston, TX. and 173.310. transportation...., 172.101, Column (9B), transportation in Twin Falls, ID. Sec. 172.204(c)(3), commerce of Acetylene, Sec....101 To authorize the Outdoor column (8C), 173.241, transportation in Adventures, LLC, 173.242, 175.310...

77 FR 55105 - Aging Airplane Program: Widespread Fatigue Damage; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-07

... final rule published November 15, 2010. The final rule required design approval holders of certain... compliance dates of Sec. Sec. 26.21, 121.1115, and 129.115 for Airbus A310 and A300-600 series airplanes... A300 B4-203 30 34,000 FC A300-600 Series 60 30,000 FC/67,500 FH A310-200 Series 60 40,000 FC/60,000 FH...

8 CFR 204.12 - How can second-preference immigrant physicians be granted a national interest waiver based on...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false How can second-preference immigrant... REGULATIONS IMMIGRANT PETITIONS Immigrant Visa Petitions § 204.12 How can second-preference immigrant... osteopathy) for whom an immigrant visa petition has been filed pursuant to section 203(b)(2) of the Act shall...

FASINEX (Frontal Air-Sea Interaction Experiment), January-June 1986. Summaries for FASINEX Mooring Cruises. Phase One: R/V KNORR 119. Phase Three: R/V KNORR Cruise 123.

DTIC Science & Technology

1986-10-01

639 644 549 664 669 664 669 0-~ JI 700 (KNOR 119)- 143 14s Xolr Goo-4* a.58 258 21 XB UME 570 57 w05859 9 0 - . I , , I , - I - , , , I , I . I...12 Jan 25041.65 69056.77 202 0830 12 Jan 25039.43 69°56.85 Ii 203 0845 12 Jan 25037.23 69056.89 204 0900 12 Jan 25034.99 69057.03 205 0915 12 Jan...0845 22 Jun 29004.48 70006.92 203 0900 22 Jun 29012.17 7007.31 204 0915 22 Jun 29015.33 70007.80 205 0945 22 Jun 29020.39 70008.21 206 1000 22 Jun

44 CFR 2.2 - OMB control numbers assigned to information collections.

Code of Federal Regulations, 2012 CFR

2012-10-01

... to information collections. 2.2 Section 2.2 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL OMB CONTROL NUMBERS § 2.2 OMB control numbers....202(f)(2), 206.203(c), 206.203(d)(i), 206.204(f) 1660-0017 206 subpart K 1660-0082, 1660-0083 206...

44 CFR 2.2 - OMB control numbers assigned to information collections.

Code of Federal Regulations, 2010 CFR

2010-10-01

... to information collections. 2.2 Section 2.2 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL OMB CONTROL NUMBERS § 2.2 OMB control numbers....202(f)(2), 206.203(c), 206.203(d)(i), 206.204(f) 1660-0017 206 subpart K 1660-0082, 1660-0083 206...

44 CFR 2.2 - OMB control numbers assigned to information collections.

Code of Federal Regulations, 2014 CFR

2014-10-01

... to information collections. 2.2 Section 2.2 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL OMB CONTROL NUMBERS § 2.2 OMB control numbers....202(f)(2), 206.203(c), 206.203(d)(i), 206.204(f) 1660-0017 206 subpart K 1660-0082, 1660-0083 206...

44 CFR 2.2 - OMB control numbers assigned to information collections.

Code of Federal Regulations, 2011 CFR

2011-10-01

... to information collections. 2.2 Section 2.2 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL OMB CONTROL NUMBERS § 2.2 OMB control numbers....202(f)(2), 206.203(c), 206.203(d)(i), 206.204(f) 1660-0017 206 subpart K 1660-0082, 1660-0083 206...

44 CFR 2.2 - OMB control numbers assigned to information collections.

Code of Federal Regulations, 2013 CFR

2013-10-01

... to information collections. 2.2 Section 2.2 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL OMB CONTROL NUMBERS § 2.2 OMB control numbers....202(f)(2), 206.203(c), 206.203(d)(i), 206.204(f) 1660-0017 206 subpart K 1660-0082, 1660-0083 206...

46 CFR 310.5 - Personnel.

Code of Federal Regulations, 2014 CFR

2014-10-01

... training cruise the Training Ship shall have assigned one or more radio officers holding a valid license... Office of Management and Budget under control number 2133-0010) (Sec. 204(b), Merchant Marine Act, 1936...

46 CFR 310.5 - Personnel.

Code of Federal Regulations, 2012 CFR

2012-10-01

... training cruise the Training Ship shall have assigned one or more radio officers holding a valid license... Office of Management and Budget under control number 2133-0010) (Sec. 204(b), Merchant Marine Act, 1936...

46 CFR 310.5 - Personnel.

Code of Federal Regulations, 2013 CFR

2013-10-01

... training cruise the Training Ship shall have assigned one or more radio officers holding a valid license... Office of Management and Budget under control number 2133-0010) (Sec. 204(b), Merchant Marine Act, 1936...

46 CFR 310.5 - Personnel.

Code of Federal Regulations, 2011 CFR

2011-10-01

... training cruise the Training Ship shall have assigned one or more radio officers holding a valid license... Office of Management and Budget under control number 2133-0010) (Sec. 204(b), Merchant Marine Act, 1936...

Residual waste from Hanford tanks 241-C-203 and 241-C-204. 2. Contaminant release model.

PubMed

Cantrell, Kirk J; Krupka, Kenneth M; Deutsch, William J; Lindberg, Michael J

2006-06-15

Release of U and 99Tc from residual sludge in Hanford waste tanks 241-C-203 and 241-C-204 atthe U.S. Department of Energy's (DOE) Hanford Site in southeastern Washington state was quantified by water-leaching, selective extractions, empirical solubility measurements, and thermodynamic modeling. A contaminant release model was developed based on these experimental results and solid-phase characterization results presented elsewhere. Uranium release was determined to be controlled by two phases and occurred in three stages. In the first stage, U release is controlled by the solubility of tejkaite, which is suppressed by high concentrations of sodium released from the dissolution of NaNO3 in the residual sludges. Equilibrium solubility calculations indicate the U released during this stage will have a maximum concentration of 0.021 M. When all the NaNO3 has dissolved from the sludge, the solubility of the remaining cejkaite will increase to 0.28 M. After cejkaite has completely dissolved, the majority of the remaining U is in the form of poorly crystalline Na2U2O7 [or clarkeite Na[(UO2)O(OH)](H20)0-1]. In contact with Hanford groundwater this phase is not stable, and becquerelite becomes the U solubility controlling phase, with a calculated equilibrium concentration of 1.2 x 10(-4) M. For Tc, a significant fraction of its concentration in the residual sludge was determined to be relatively insoluble (20 wt % for C-203 and 80 wt % for C-204). Because of the low concentrations of Tc in these sludge materials, the characterization studies did not identify any discrete Tc solids phases. Release of the soluble fraction of Tc was found to occur concomitantly with NO3-. It was postulated that a NaNO3-NaTcO4 solid solution could be responsible for this behavior. The Tc release concentrations for the soluble fraction were estimated to be 2.4 x 10-6 M for C-203 and 2.7 x 10(-5) M for C-204. Selective extraction results indicated that the recalcitrant fraction of Tc was associated with Fe oxides. Release of the recalcitrant fraction of Tc was assumed to be controlled by dissolution of Fe oxide in the form of ferrihydrite. Based on this assumption and measured values for the ratio of recalcitrant Tc to total Fe in each bulk sludge, the release concentration of the recalcitrant fraction of Tc was calculated to be 3.9 x 10(-12) M for C-203 and 10.0 x 10(-12) M for C-204.

75 FR 11428 - Airworthiness Directives; Airbus Model A300 B2-1C, B2-203, B2K-3C, B4-103, B4-203, B4-2C...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-11

...-0789; Directorate Identifier 2008-NM-185-AD; Amendment 39-16228; AD 2010-06-04] RIN 2120-AA64..., A310-54-2018 and A300-54-6015. * * * This AD requires the implementation of this * * * inspection... that table were derived from the note in the Configuration 01 table in paragraph 1.E.(2) of Airbus...

Wargaming; A Selected Bibliography

DTIC Science & Technology

1994-04-01

Memorandum CRM 86-20. Alexandria, February 1986. 12pp. (V250 P472 1986) Center for Naval Analyses. War-gaming and Its Uses, by Peter P. Perla and Raymond T...Battle. London: Arms and Armour Press, 1988. 142pp. (U310. M44 1988) Mobley, Arthur Scott, Jr. Beyond the Black Box: An Assessment of Strategic War Gaming...William W. Banks et al. San Diego: Naval Health Research Center, 1989. 283pp. DTIC, AD-A222 541. (U310 .P65 1989) Quanrie, Bruce. Armoured Wargaming: A

46 CFR 310.60 - Training on subsidized vessels.

Code of Federal Regulations, 2013 CFR

2013-10-01

... passenger quarters) and shall mess with the licensed officers. The steamship company employers shall also... in first-class passenger quarters) and shall mess with the licensed officers. (Secs. 204(b) and 1301...

46 CFR 310.60 - Training on subsidized vessels.

Code of Federal Regulations, 2012 CFR

2012-10-01

... passenger quarters) and shall mess with the licensed officers. The steamship company employers shall also... in first-class passenger quarters) and shall mess with the licensed officers. (Secs. 204(b) and 1301...

46 CFR 310.60 - Training on subsidized vessels.

Code of Federal Regulations, 2014 CFR

2014-10-01

... passenger quarters) and shall mess with the licensed officers. The steamship company employers shall also... in first-class passenger quarters) and shall mess with the licensed officers. (Secs. 204(b) and 1301...

Hydrographic Measurements in the Strait of Gibraltar, June 1986

DTIC Science & Technology

1987-04-01

59.2 051 201 170 19 Jun 1358 57 36-04.5 5-50.0 052 202 170 19 Jun 1427 168 36-02.2 5-50.5 053 203 170 19 Jun 1501 198 35-59.9 5-50.9 054 204 170 19...04.4 061 202 170 19 Jun 2154 128 36-02.2 062 203 170 19 Jun 2223 207 36-00.5 063 204 170 19 Jun 2306 426 35-57.7 064 205 171 20 Jun 0010 277 35...Jun 0605 6i>9 35-55.1 5-38.8 192 802 176 25 Jun 0640 669 35-55.0 5-38.8 193 802 176 25 Jun 0736 636 35-55.0 5-38.9 194 802 176 25 Jun 0800 640 35

75 FR 34258 - Federal Acquisition Regulation; FAR Case 2009-012, American Recovery and Reinvestment Act (the...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-16

... clause at FAR 52.203-15(b) to apply only to subcontracts that are funded in whole or in part with the... implemented by FAR 52.203-15 and included in contracts for commercial items by FAR 52.212-5(b)(3), it is not... be indicated as a ``check-off'' clause as has been noted for FAR 52.212-5(b)(4), and FAR 52.204-11...

30 CFR 250.1900 - Must I have a SEMS program?

Code of Federal Regulations, 2013 CFR

2013-07-01

... Environmental Management Program for Offshore Operations and Facilities (API RP 75) (as incorporated by... conflicts between the requirements of this subpart and API RP 75; COS-2-01, COS-2-03, or COS-2-04; or ISO...

30 CFR 250.1900 - Must I have a SEMS program?

Code of Federal Regulations, 2014 CFR

2014-07-01

... Environmental Management Program for Offshore Operations and Facilities (API RP 75) (as incorporated by... conflicts between the requirements of this subpart and API RP 75; COS-2-01, COS-2-03, or COS-2-04; or ISO...

78 FR 7261 - Airworthiness Directives; Airbus Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-01

... Airworthiness Directives; Airbus Airplanes AGENCY: Federal Aviation Administration (FAA), Department of... Airbus Model A310-203 airplanes. This AD was prompted by a report of an analysis that demonstrated a...-116, Transport Airplane Directorate, FAA, 1601 Lind Avenue SW., Renton, WA 98057-3356; telephone (425...

Satellites measure recent rates of groundwater depletion in California's Central Valley

NASA Astrophysics Data System (ADS)

Famiglietti, J. S.; Lo, M.; Ho, S. L.; Bethune, J.; Anderson, K. J.; Syed, T. H.; Swenson, S. C.; de Linage, C. R.; Rodell, M.

2011-02-01

In highly-productive agricultural areas such as California's Central Valley, where groundwater often supplies the bulk of the water required for irrigation, quantifying rates of groundwater depletion remains a challenge owing to a lack of monitoring infrastructure and the absence of water use reporting requirements. Here we use 78 months (October, 2003-March, 2010) of data from the Gravity Recovery and Climate Experiment satellite mission to estimate water storage changes in California's Sacramento and San Joaquin River Basins. We find that the basins are losing water at a rate of 31.0 ± 2.7 mm yr-1 equivalent water height, equal to a volume of 30.9 km3 for the study period, or nearly the capacity of Lake Mead, the largest reservoir in the United States. We use additional observations and hydrological model information to determine that the majority of these losses are due to groundwater depletion in the Central Valley. Our results show that the Central Valley lost 20.4 ± 3.9 mm yr-1 of groundwater during the 78-month period, or 20.3 km3 in volume. Continued groundwater depletion at this rate may well be unsustainable, with potentially dire consequences for the economic and food security of the United States.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pang, Xiaoyun; Xu, Feng, E-mail: xuf@xtal.tsinghua.edu.cn; Bell, Stephen G.

The cytochrome P450 enzyme CYP203A1 from Rhodopseudomonas palustris binds a wide range of highly substituted aromatic compounds and may play an important role in the astonishing metabolic diversity of this organism. Crystals of CYP203A1 that diffract to 2.0 Å resolution have been obtained. Cytochrome P450 enzymes constitute a large family of haemoproteins that catalyze the monooxygenation of a great variety of endogenous and exogenous organic compounds. Cytochrome P450 203A1 (CYP203A1, RPA1009) from the metabolically versatile organism Rhodopseudomonas palustris binds a broad range of substrates, in particular substituted aromatic compounds. Crystals of CYP203A1 suitable for X-ray crystallography have been obtained andmore » diffraction data were collected in-house to 2.0 Å resolution from a single crystal. The crystals belong to space group P222, with unit-cell parameters a = 40.1, b = 95.1, c = 99.0 Å, α = β = γ = 90°. There is one protein molecule per asymmetric unit.« less

45 CFR 160.203 - General rule and exceptions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... law, as applicable, provides for the reporting of disease or injury, child abuse, birth, or death, or... § 160.204 that the provision of State law: (1) Is necessary: (i) To prevent fraud and abuse related to...

45 CFR 160.203 - General rule and exceptions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... law, as applicable, provides for the reporting of disease or injury, child abuse, birth, or death, or... § 160.204 that the provision of State law: (1) Is necessary: (i) To prevent fraud and abuse related to...

45 CFR 160.203 - General rule and exceptions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... law, as applicable, provides for the reporting of disease or injury, child abuse, birth, or death, or... § 160.204 that the provision of State law: (1) Is necessary: (i) To prevent fraud and abuse related to...

45 CFR 160.203 - General rule and exceptions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... law, as applicable, provides for the reporting of disease or injury, child abuse, birth, or death, or... § 160.204 that the provision of State law: (1) Is necessary: (i) To prevent fraud and abuse related to...

45 CFR 160.203 - General rule and exceptions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... law, as applicable, provides for the reporting of disease or injury, child abuse, birth, or death, or... § 160.204 that the provision of State law: (1) Is necessary: (i) To prevent fraud and abuse related to...

48 CFR 1837.203-70 - Providing contractors access to sensitive information.

Code of Federal Regulations, 2014 CFR

2014-10-01

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPECIAL CATEGORIES OF CONTRACTING SERVICE CONTRACTING... contract, as a compliance document. (e) If the service provider will be operating an information technology... 1852.204-76, Security Requirements for Unclassified Information Technology Resources, which requires...

48 CFR 1837.203-70 - Providing contractors access to sensitive information.

Code of Federal Regulations, 2012 CFR

2012-10-01

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPECIAL CATEGORIES OF CONTRACTING SERVICE CONTRACTING... contract, as a compliance document. (e) If the service provider will be operating an information technology... 1852.204-76, Security Requirements for Unclassified Information Technology Resources, which requires...

48 CFR 1837.203-70 - Providing contractors access to sensitive information.

Code of Federal Regulations, 2013 CFR

2013-10-01

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPECIAL CATEGORIES OF CONTRACTING SERVICE CONTRACTING... contract, as a compliance document. (e) If the service provider will be operating an information technology... 1852.204-76, Security Requirements for Unclassified Information Technology Resources, which requires...

Genetics Home Reference: cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

MedlinePlus

... and leukoencephalopathy: phenotypic and mutational spectrum. J Neurol Sci. 2002 Nov 15;203-204:77-80. Review. ... The pathogenesis of CADASIL: an update. J Neurol Sci. 2004 Nov 15;226(1-2):35-9. ...

Long-term safety and efficacy of dalfampridine for walking impairment in patients with multiple sclerosis: Results of open-label extensions of two Phase 3 clinical trials

PubMed Central

Goodman, Andrew D; Bethoux, Francois; Brown, Theodore R; Schapiro, Randall T; Cohen, Ron; Marinucci, Lawrence N; Henney, Herbert R

2015-01-01

Background: In Phase 3 double-blind trials (MS-F203 and MS-F204), dalfampridine extended release tablets 10 mg twice daily (dalfampridine-ER; prolonged-release fampridine in Europe; fampridine modified or sustained release elsewhere) improved walking speed relative to placebo in patients with multiple sclerosis (MS). Objectives: Evaluation of long-term safety and efficacy of dalfampridine-ER in open-label extensions (MS-F203EXT, MS-F204EXT). Methods: Patients received dalfampridine-ER 10 mg twice daily; and had Timed 25-Foot Walk (T25FW) assessments at 2, 14 and 26 weeks, and then every 6 months. Subjects were categorized as dalfampridine-ER responders or non-responders, based on their treatment response in the double-blind parent trials that assessed T25FW. Results: We had 269 patients enter MS-F203EXT and 154 patients complete it; for a maximum exposure of 5 years. We had 214 patients enter MS-F204EXT and 146 complete it; for a maximum exposure of 3.3 years. No new safety signals emerged and dalfampridine-ER tolerability was consistent with the double-blind phase. Improvements in walking speed were lost after dalfampridine-ER was discontinued in the parent trial, but returned by the 2-week assessment after re-initiation of the drug. Throughout the extensions, mean improvement in walking speed declined, but remained improved, among the double-blind responders as compared with non-responders. Conclusions: The dalfamipridine-ER safety profile was consistent with the parent trials. Although walking speed decreased over time, dalfampridine-ER responders continued to show improved walking speed, which was sustained compared with non-responders. PMID:25583832

Lipid characteristics of a seep clam, Mesolinga soliditesta: Comparison with those of two coastal clams, Meretrix lamarckii and Ruditapes philippinarum

NASA Astrophysics Data System (ADS)

Saito, Hiroaki; Murata, Masakazu; Hashimoto, Jun

2014-12-01

The lipids and fatty acids of two coastal clams, Meretrix lamarckii and Ruditapes philippinarum, collected at 5 and 1 m of depth, and a seep clam, Mesolinga soliditesta, collected at 331 m of depth, were examined to assess their lipid physiology and trophic relationship with their diets. The major fatty acids of lipids in Mer. lamarckii and R. philippinarum were 14:0, 16:0, 18:0, 16:1n-7, 18:1n-9, 18:1n-7, 20:4n-6, 20:5n-3, and 22:6n-3, while those of Mes. soliditesta were 16:0, 18:0, 16:1n-7, 18:1n-7, 20:1n-7, 20:1n-13, 20:2n-7, 15 (Δ5,13-20:2), and 22:2n-7,15 (Δ7,15-22:2). The major polyunsaturated fatty acids (PUFAs) in the Mer. lamarckii and R. philippinarum lipids consisted of various n-3 and n-6 long-chain (LC) PUFAs, such as 20:4n-6, 22:4n-6, 20:5n-3, 22:5n-3, and 22:6n-3, while those in Mes. soliditesta muscle and viscera included various n-4 family PUFAs (18:3n-7, 18:4n-4, 20:2n-7, and 20:3n-7) with limited kinds of n-3 and n-6 PUFAs (20:4n-6 and 20:5n-3). These findings indicate that, like other common shallow-water clams, Mer. lamarckii and R. philippinarum ingest phytoplanktonic n-3 and n-6 LC-PUFAs, whereas Mes. soliditesta utilizes limited kinds of n-3 and n-6 LC-PUFAs. In contrast to the other two bivalves species, Mes. soliditesta yielded various n-4 and n-7 (n-4/n-7) PUFAs, which were assimilated from the chemosynthetic symbionts. The high diversity of PUFAs contained in the Mes. soliditesta lipids (n-3, n-4 family, and n-6 PUFAs) suggests that this species mixotrophically utilized both photosynthetic products and vent chemosynthetic nutrition derived from geothermal energy.

77 FR 47922 - BNSF Railway Company-Trackage Rights Exemption-Northern Lines Railway, Inc.

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-10

... includes: (a) Track 204 between 33rd Avenue North and Rice Junction, Minn.; and (b) Track 203 between milepost 0.0, at Rice Junction, and milepost 5.71, just west of the Highway I-94 overpass (the Lines). \\1...

Cross sections of proton-induced nuclear reactions on bismuth and lead up to 100 MeV

NASA Astrophysics Data System (ADS)

Mokhtari Oranj, L.; Jung, N. S.; Bakhtiari, M.; Lee, A.; Lee, H. S.

2017-04-01

Production cross sections of 209Bi(p , x n )207,206,205,204,203Po, 209Bi(p , pxn) 207,206,205,204,203,202Bi, and natPb(p , x n ) 206,205,204,203,202,201Bi reactions were measured to fill the gap in the excitation functions up to 100 MeV as well as to figure out the effects of different nuclear properties on proton-induced reactions including heavy nuclei. The targets were arranged in two different stacks consisting of Bi, Pb, Al, Au foils and Pb plates. The proton beam intensity was determined by the activation analysis method using 27Al(p ,3 p n )24Na, 197Au(p ,p n )196Au, and 197Au(p , p 3 n )194Au monitor reactions in parallel as well as the Gafchromic film dosimetry method. The activities of produced radionuclei in the foils were measured by the HPGe spectroscopy system. Over 40 new cross sections were measured in the investigated energy range. A satisfactory agreement was observed between the present experimental data and the previously published data. Excitation functions of mentioned reactions were calculated by using the theoretical model based on the latest version of the TALYS code and compared to the new data as well as with other data in the literature. Additionally, the effects of various combinations of the nuclear input parameters of different level density models, optical model potentials, and γ-ray strength functions were considered. It was concluded that if certain level density models are used, the calculated cross sections could be comparable to the measured data. Furthermore, the effects of optical model potential and γ-ray strength functions were considerably lower than that of nuclear level densities.

23 CFR 660.101 - Purpose.

Code of Federal Regulations, 2011 CFR

2011-04-01

..., 203, and 204, the program, developed in cooperation with State and local agencies, provides safe and... HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS SPECIAL PROGRAMS... Highway (FH) Program which enhances local, regional, and national benefits of FHs funded under the public...

23 CFR 660.101 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., 203, and 204, the program, developed in cooperation with State and local agencies, provides safe and... HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS SPECIAL PROGRAMS... Highway (FH) Program which enhances local, regional, and national benefits of FHs funded under the public...

48 CFR 4.203 - Taxpayer identification information.

Code of Federal Regulations, 2010 CFR

2010-10-01

... furnished a Taxpayer Identification Number (TIN) when completing the solicitation provision at 52.204-3... the contract sent to the payment office. (b) If the TIN or type of organization is derived from a... last page of the contract or order forwarded to the payment office to state the contractor's TIN and...

48 CFR 4.203 - Taxpayer identification information.

Code of Federal Regulations, 2011 CFR

2011-10-01

... furnished a Taxpayer Identification Number (TIN) when completing the solicitation provision at 52.204-3... the contract sent to the payment office. (b) If the TIN or type of organization is derived from a... last page of the contract or order forwarded to the payment office to state the contractor's TIN and...

48 CFR 4.203 - Taxpayer identification information.

Code of Federal Regulations, 2013 CFR

2013-10-01

... furnished a Taxpayer Identification Number (TIN) when completing the solicitation provision at 52.204-3... the contract sent to the payment office. (b) If the TIN or type of organization is derived from a... last page of the contract or order forwarded to the payment office to state the contractor's TIN and...

48 CFR 4.203 - Taxpayer identification information.

Code of Federal Regulations, 2014 CFR

2014-10-01

... furnished a Taxpayer Identification Number (TIN) when completing the solicitation provision at 52.204-3... the contract sent to the payment office. (b) If the TIN or type of organization is derived from a... last page of the contract or order forwarded to the payment office to state the contractor's TIN and...

48 CFR 4.203 - Taxpayer identification information.

Code of Federal Regulations, 2012 CFR

2012-10-01

... furnished a Taxpayer Identification Number (TIN) when completing the solicitation provision at 52.204-3... the contract sent to the payment office. (b) If the TIN or type of organization is derived from a... last page of the contract or order forwarded to the payment office to state the contractor's TIN and...

Comparing Genomes in Terms of Protein Structure: Surveys of a Finite Parts List

DTIC Science & Technology

1998-01-01

539-547. 39. Fraser, C M, et al. (1997) Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi [see comments]. Nature 390, 580-586. 40...Methanobacterium thermoautotrophicum [202] BS Bacillus subtilis [203] AB Archaeoglobus fulgidus [204] BB Borrelia burgdorferi [39] AA Aquifex aeolicus

40 CFR Appendix A to Part 97 - Final Section 126 Rule: EGU Allocations, 2004-2007

Code of Federal Regulations, 2012 CFR

2012-07-01

... VA POSSUM POINT 3804 4 528 VA POSSUM POINT 3804 5 322 VA POTOMAC RIVER 3788 1 203 VA POTOMAC RIVER 3788 2 139 VA POTOMAC RIVER 3788 3 232 VA POTOMAC RIVER 3788 4 223 VA POTOMAC RIVER 3788 5 222 VA SEI...

40 CFR Appendix A to Part 97 - Final Section 126 Rule: EGU Allocations, 2004-2007

Code of Federal Regulations, 2013 CFR

2013-07-01

... VA POSSUM POINT 3804 4 528 VA POSSUM POINT 3804 5 322 VA POTOMAC RIVER 3788 1 203 VA POTOMAC RIVER 3788 2 139 VA POTOMAC RIVER 3788 3 232 VA POTOMAC RIVER 3788 4 223 VA POTOMAC RIVER 3788 5 222 VA SEI...

40 CFR Appendix A to Part 97 - Final Section 126 Rule: EGU Allocations, 2004-2007

Code of Federal Regulations, 2014 CFR

2014-07-01

... VA POSSUM POINT 3804 4 528 VA POSSUM POINT 3804 5 322 VA POTOMAC RIVER 3788 1 203 VA POTOMAC RIVER 3788 2 139 VA POTOMAC RIVER 3788 3 232 VA POTOMAC RIVER 3788 4 223 VA POTOMAC RIVER 3788 5 222 VA SEI...

An Analysis of Human Causal Factors in Unmanned Aerial Vehicle (UAV) Accidents

DTIC Science & Technology

2014-12-01

202 • Drugs/over-the-counter medication/supplements (not prescribed) PP 203 • Nutrition/ diet PP 204 • Inadequate rest (self-imposed) PP 205...2008). A survey of unmanned aircraft systems regulation: Status and future perspectives. Paper presented at 16th Mediterranean Conference on Control

48 CFR 39.204 - Exceptions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... requirements in 39.203 do not apply to EIT that— (a) Is purchased in accordance with Subpart 13.2 (micro-purchases) prior to April 1, 2005. However, for micro-purchases, contracting officers and other individuals... writing the basis for an undue burden decision and provide the documentation to the contracting officer...

Pubertal development in children diagnosed with diabetes mellitus type 1 before puberty.

PubMed

Pereira, K C X; Pugliese, B S; Guimarães, M M; Gama, M P

2015-02-01

To investigate an association between pubertal development and timing of menarche with glycemic control, disease duration, and body mass index (BMI) in patients diagnosed with diabetes mellitus type 1 (DM1) before puberty. Retrospective study. The study was performed at the diabetes outpatient clinic of Instituto de Puericultura e Pediatria Martagão Gesteira--IPPMG of the Federal University of Rio de Janeiro--UFRJ. A total of 131 children, 61 girls and 70 boys, diagnosed with DM1 before puberty participated in the study. The study investigated how age at puberty onset relates to mean glycated hemoglobin (HbA1c) before puberty, BMI percentile, and disease duration; how puberty duration relates to mean HbA1c before and during puberty and to disease duration; and how timing of menarche relates to mean HbA1c before puberty, BMI percentile, and disease duration. Age at puberty onset was positively correlated with mean HbA1c before puberty (r = 0.204, R(2) = 0.042; P = .019) and disease duration (r = 0.451, R(2) = 0.203; P < .0001), and negatively correlated with BMI percentile (r = -0.289, R(2) = 0.084; P = .001). Timing of menarche was negatively correlated with BMI percentile (r = -0.556, R(2) = 0.310; P < .001). Children with longer disease duration began puberty later than those diagnosed more recently. Girls in higher BMI percentiles reached menarche sooner.

42 CFR 457.208 - Judicial review.

Code of Federal Regulations, 2010 CFR

2010-10-01

... dissatisfied with the Administrator's final determination on approvability of plan material (§ 457.203) or compliance with Federal requirements (§ 457.204) has a right to judicial review. (b) Petition for review. (1) The State must file a petition for review with the U.S. Court of Appeals for the circuit in which the...

78 FR 40043 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-03

....470-4; 216.203-4-70; 225.1101; 225.1103; 225.7605; 229.402-70; and 247.574. List of Subjects in 48 CFR... 52.204-7'' in its place. 225.1103 [Amended] 0 7. Amend paragraph (3) of section 225.1103 by removing...

21 CFR 172.833 - Sucrose acetate isobutyrate (SAIB).

Code of Federal Regulations, 2010 CFR

2010-04-01

.../federal_register/code_of_federal_regulations/ibr_locations.html. (5) Triacetin: Not to exceed 0.10 percent..., Addendum 4, Food and Agriculture Organization of the United Nations (FAO), Food and Nutrition Paper 5, Revision 2” (1991), pp. 203 and 204, which is incorporated by reference, in accordance with 5 U.S.C. 552(a...

77 FR 66975 - Black Bear SO, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-08

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-203-000] Black Bear SO, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Black Bear SO...

5 CFR 843.211 - Determining when children prevent payment of the unexpended balance.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Determining when children prevent payment of the unexpended balance. 843.211 Section 843.211 Administrative Personnel OFFICE OF PERSONNEL... unexpended balance. Someone entitled to an annuity for purposes of §§ 843.203 and 843.204 includes a child...

5 CFR 843.211 - Determining when children prevent payment of the unexpended balance.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false Determining when children prevent payment of the unexpended balance. 843.211 Section 843.211 Administrative Personnel OFFICE OF PERSONNEL... unexpended balance. Someone entitled to an annuity for purposes of §§ 843.203 and 843.204 includes a child...

7 CFR 760.210 - Honeybee payment calculations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... provided in § 760.203(g), based on 60 percent of the producer's actual cost for honeybee feed that was: (1... producer's actual replacement cost for a honeybee colony that was damaged or destroyed due to an eligible... feed for an eligible honeybee colony, as provided in § 760.204(g); (b) An eligible honeybee producer...

Depth profile of production yields of natPb(p, xn) 206,205,204,203,202,201Bi nuclear reactions

NASA Astrophysics Data System (ADS)

Mokhtari Oranj, Leila; Jung, Nam-Suk; Kim, Dong-Hyun; Lee, Arim; Bae, Oryun; Lee, Hee-Seock

2016-11-01

Experimental and simulation studies on the depth profiles of production yields of natPb(p, xn) 206,205,204,203,202,201Bi nuclear reactions were carried out. Irradiation experiments were performed at the high-intensity proton linac facility (KOMAC) in Korea. The targets, irradiated by 100-MeV protons, were arranged in a stack consisting of natural Pb, Al, Au foils and Pb plates. The proton beam intensity was determined by activation analysis method using 27Al(p, 3p1n)24Na, 197Au(p, p1n)196Au, and 197Au(p, p3n)194Au monitor reactions and also by Gafchromic film dosimetry method. The yields of produced radio-nuclei in the natPb activation foils and monitor foils were measured by HPGe spectroscopy system. Monte Carlo simulations were performed by FLUKA, PHITS/DCHAIN-SP, and MCNPX/FISPACT codes and the calculated data were compared with the experimental results. A satisfactory agreement was observed between the present experimental data and the simulations.

Thin film buried anode battery

DOEpatents

Lee, Se-Hee [Lakewood, CO; Tracy, C Edwin [Golden, CO; Liu, Ping [Denver, CO

2009-12-15

A reverse configuration, lithium thin film battery (300) having a buried lithium anode layer (305) and process for making the same. The present invention is formed from a precursor composite structure (200) made by depositing electrolyte layer (204) onto substrate (201), followed by sequential depositions of cathode layer (203) and current collector (202) on the electrolyte layer. The precursor is subjected to an activation step, wherein a buried lithium anode layer (305) is formed via electroplating a lithium anode layer at the interface of substrate (201) and electrolyte film (204). The electroplating is accomplished by applying a current between anode current collector (201) and cathode current collector (202).

(222)Rn activity in groundwater of the St. Lawrence Lowlands, Quebec, eastern Canada: relation with local geology and health hazard.

PubMed

Pinti, Daniele L; Retailleau, Sophie; Barnetche, Diogo; Moreira, Floriane; Moritz, Anja M; Larocque, Marie; Gélinas, Yves; Lefebvre, René; Hélie, Jean-François; Valadez, Arisai

2014-10-01

One hundred ninety-eight groundwater wells were sampled to measure the (222)Rn activity in the region between Montreal and Quebec City, eastern Canada. The aim of this study was to relate the spatial distribution of (222)Rn activity to the geology and the hydrogeology of the study area and to estimate the potential health risks associated with (222)Rn in the most populated area of the Province of Quebec. Most of the groundwater samples show low (222)Rn activities with a median value of 8.6 Bq/L. Ninety percent of samples show (222)Rn activity lower than 100 Bq/L, the exposure limit in groundwater recommended by the World Health Organization. A few higher (222)Rn activities (up to 310 Bq/L) have been measured in wells from the Appalachian Mountains and from the magmatic intrusion of Mont-Saint-Hilaire, known for its high level of indoor radon. The spatial distribution of (222)Rn activity seems to be related mainly to lithology differences between U-richer metasediments of the Appalachian Mountains and magmatic intrusions and the carbonaceous silty shales of the St. Lawrence Platform. Radon is slightly enriched in sodium-chlorine waters that evolved at contact with clay-rich formations. (226)Ra, the parent element of (222)Rn could be easily adsorbed on clays, creating a favorable environment for the production and release of (222)Rn into groundwater. The contribution of groundwater radon to indoor radon or by ingestion is minimal except for specific areas near Mont-Saint-Hilaire or in the Appalachian Mountains where this contribution could reach 45% of the total radioactive annual dose. Copyright © 2014 Elsevier Ltd. All rights reserved.

50 CFR 222.310 - Permit authority for designated agents and employees of specified Federal and state agencies.

Code of Federal Regulations, 2010 CFR

2010-10-01

... stranded endangered sea turtles, and to salvage, collect data from, and dispose of, dead carcasses of... member of any endangered species of sea turtle is found stranded or dead in the marine environment, any... taking is necessary to aid a stranded sea turtle, or dispose of or salvage a dead sea turtle, or collect...

50 CFR 222.310 - Permit authority for designated agents and employees of specified Federal and state agencies.

Code of Federal Regulations, 2011 CFR

2011-10-01

... stranded endangered sea turtles, and to salvage, collect data from, and dispose of, dead carcasses of... member of any endangered species of sea turtle is found stranded or dead in the marine environment, any... taking is necessary to aid a stranded sea turtle, or dispose of or salvage a dead sea turtle, or collect...

The Fatty Acid Profile Analysis of Cyperus laxus Used for Phytoremediation of Soils from Aged Oil Spill-Impacted Sites Revealed That This Is a C18:3 Plant Species.

PubMed

Rivera Casado, Noemí Araceli; Montes Horcasitas, María del Carmen; Rodríguez Vázquez, Refugio; Esparza García, Fernando José; Pérez Vargas, Josefina; Ariza Castolo, Armando; Ferrera-Cerrato, Ronald; Gómez Guzmán, Octavio; Calva Calva, Graciano

2015-01-01

The effect of recalcitrant hydrocarbons on the fatty acid profile from leaf, basal corm, and roots of Cyperus laxus plants cultivated in greenhouse phytoremediation systems of soils from aged oil spill-impacted sites containing from 16 to 340 g/Kg total hydrocarbons (THC) was assessed to investigate if this is a C18:3 species and if the hydrocarbon removal during the phytoremediation process has a relationship with the fatty acid profile of this plant. The fatty acid profile was specific to each vegetative organ and was strongly affected by the hydrocarbons level in the impacted sites. Leaf extracts of plants from uncontaminated soil produced palmitic acid (C16), octadecanoic acid (C18:0), unsaturated oleic acids (C18:1-C18:3), and unsaturated eichosanoic (C20:2-C20:3) acids with a noticeable absence of the unsaturated hexadecatrienoic acid (C16:3); this finding demonstrates, for the first time, that C. laxus is a C18:3 plant. In plants from the phytoremediation systems, the total fatty acid contents in the leaf and the corm were negatively affected by the hydrocarbons presence; however, the effect was positive in root. Interestingly, under contaminated conditions, unusual fatty acids such as odd numbered carbons (C15, C17, C21, and C23) and uncommon unsaturated chains (C20:3n6 and C20:4) were produced together with a remarkable quantity of C22:2 and C24:0 chains in the corm and the leaf. These results demonstrate that weathered hydrocarbons may drastically affect the lipidic composition of C. laxus at the fatty acid level, suggesting that this species adjusts the cover lipid composition in its vegetative organs, mainly in roots, in response to the weathered hydrocarbon presence and uptake during the phytoremediation process.

The Fatty Acid Profile Analysis of Cyperus laxus Used for Phytoremediation of Soils from Aged Oil Spill-Impacted Sites Revealed That This Is a C18:3 Plant Species

PubMed Central

Montes Horcasitas, María del Carmen; Rodríguez Vázquez, Refugio; Esparza García, Fernando José; Pérez Vargas, Josefina; Ariza Castolo, Armando; Ferrera-Cerrato, Ronald; Gómez Guzmán, Octavio

2015-01-01

The effect of recalcitrant hydrocarbons on the fatty acid profile from leaf, basal corm, and roots of Cyperus laxus plants cultivated in greenhouse phytoremediation systems of soils from aged oil spill-impacted sites containing from 16 to 340 g/Kg total hydrocarbons (THC) was assessed to investigate if this is a C18:3 species and if the hydrocarbon removal during the phytoremediation process has a relationship with the fatty acid profile of this plant. The fatty acid profile was specific to each vegetative organ and was strongly affected by the hydrocarbons level in the impacted sites. Leaf extracts of plants from uncontaminated soil produced palmitic acid (C16), octadecanoic acid (C18:0), unsaturated oleic acids (C18:1-C18:3), and unsaturated eichosanoic (C20:2-C20:3) acids with a noticeable absence of the unsaturated hexadecatrienoic acid (C16:3); this finding demonstrates, for the first time, that C. laxus is a C18:3 plant. In plants from the phytoremediation systems, the total fatty acid contents in the leaf and the corm were negatively affected by the hydrocarbons presence; however, the effect was positive in root. Interestingly, under contaminated conditions, unusual fatty acids such as odd numbered carbons (C15, C17, C21, and C23) and uncommon unsaturated chains (C20:3n6 and C20:4) were produced together with a remarkable quantity of C22:2 and C24:0 chains in the corm and the leaf. These results demonstrate that weathered hydrocarbons may drastically affect the lipidic composition of C. laxus at the fatty acid level, suggesting that this species adjusts the cover lipid composition in its vegetative organs, mainly in roots, in response to the weathered hydrocarbon presence and uptake during the phytoremediation process. PMID:26473488

21 CFR 172.833 - Sucrose acetate isobutyrate (SAIB).

Code of Federal Regulations, 2014 CFR

2014-04-01

... Section 172.833 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Nations (FAO), Food and Nutrition Paper 5, Revision 2” (1991), pp. 203 and 204, which is incorporated by... Food Additive Safety (HFS-200), Center for Food Safety and Applied Nutrition, Food and Drug...

Municipal and Industrial Needs (MAIN II). St. Paul District Revision.

DTIC Science & Technology

1984-01-01

1.000 23096. 23096. 2306. 204 MARIGOLD 30. 1.000 1.000 10813. 10813. 21626.* 205 TOLONA PIZZA 26. 1.000 1.000 2050. 2050. 2050. 206 HOLSUM BAKERS 95...BEEF 382. 1.000 1.000 39034. 39034. 163943. 203 LAND 𔃺 LAKES 127. 1.000 1.000 293. 2 32. 29332. 2064 MARIGOLD 38. 1.000 1.000 13696. 13696. 27393. 205...204 MARIGOLD 46. 1.000 1.600 16580. 16580. )Vb0. 205 TOLONA PIZZA 40. 1.000 1.000 3153. 3153. 3153. 206 HOLSUM BAKERS 147. 1.000 1.000 17436. 17436

2005 Service Academies: Sexual Assault Survey: Administration, Datasets and Codebook

DTIC Science & Technology

2005-10-01

sex w/you-Uned 326 SB026SK* [26sk] Situation w/ greatest eff -Skip 204 SB027* 27. [27---] In which semester did this occur 205 SB027U* [27...Tab recode SB038CR: Commis Officer COC 669 SB038CU* [38c] Retal by officer in chain o c-Uned 370 SB038D* 38d. [38d] Retal by other academy...sex w/you 203 SB026SK [26sk] Situation w/ greatest eff -Skip 204 SB027 27. [27---] In which semester did this occur 205 SB028 28. [28---] Where

29 CFR 2530.200b-6 - Maritime industry.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 9 2010-07-01 2010-07-01 false Maritime industry. 2530.200b-6 Section 2530.200b-6 Labor... Provisions § 2530.200b-6 Maritime industry. (a) General. Sections 202(a)(3)(D), 203(b)(2)(D) and 204(b)(3)(E... provisions applicable to the maritime industry. In general, those provisions permit statutory standards...

29 CFR 2530.200b-6 - Maritime industry.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 9 2014-07-01 2014-07-01 false Maritime industry. 2530.200b-6 Section 2530.200b-6 Labor... Provisions § 2530.200b-6 Maritime industry. (a) General. Sections 202(a)(3)(D), 203(b)(2)(D) and 204(b)(3)(E... provisions applicable to the maritime industry. In general, those provisions permit statutory standards...

29 CFR 2530.200b-6 - Maritime industry.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 9 2011-07-01 2011-07-01 false Maritime industry. 2530.200b-6 Section 2530.200b-6 Labor... Provisions § 2530.200b-6 Maritime industry. (a) General. Sections 202(a)(3)(D), 203(b)(2)(D) and 204(b)(3)(E... provisions applicable to the maritime industry. In general, those provisions permit statutory standards...

29 CFR 2530.200b-6 - Maritime industry.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 9 2013-07-01 2013-07-01 false Maritime industry. 2530.200b-6 Section 2530.200b-6 Labor... Provisions § 2530.200b-6 Maritime industry. (a) General. Sections 202(a)(3)(D), 203(b)(2)(D) and 204(b)(3)(E... provisions applicable to the maritime industry. In general, those provisions permit statutory standards...

29 CFR 2530.200b-6 - Maritime industry.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 9 2012-07-01 2012-07-01 false Maritime industry. 2530.200b-6 Section 2530.200b-6 Labor... Provisions § 2530.200b-6 Maritime industry. (a) General. Sections 202(a)(3)(D), 203(b)(2)(D) and 204(b)(3)(E... provisions applicable to the maritime industry. In general, those provisions permit statutory standards...

Residual waste from Hanford tanks 241-C-203 and 241-C-204. 1. Solids characterization.

PubMed

Krupka, Kenneth M; Schaef, Herbert T; Arey, Bruce W; Heald, Steve M; Deutsch, William I; Lindberg, Michael J; Cantrell, Kirk J

2006-06-15

Bulk X-ray diffraction (XRD), synchrotron X-ray microdiffraction (microXRD), and scanning electron microscopy/ energy-dispersive X-ray spectroscopy (SEM/EDS) were used to characterize solids in residual sludge from single-shell underground waste tanks C-203 and C-204 at the U.S. Department of Energy's Hanford Site in southeastern Washington state. Cejkaite [Na4(UO2)(CO3)3] was the dominant crystalline phase in the C-203 and C-204 sludges. This is one of the few occurrences of cejkaite reported in the literature and may be the first documented occurrence of this phase in radioactive wastes from DOE sites. Characterization of residual solids from water leach and selective extraction tests indicates that cejkaite has a high solubility and a rapid rate of dissolution in water at ambient temperature and that these sludges may also contain poorly crystalline Na2U207 [or clarkeite Na[(UO2)O(OH)](H2O)0-1] as well as nitratine (soda niter, NaNO3), goethite [alpha-FeO(OH)], and maghemite (gamma-Fe2O3). Results of the SEM/EDS analyses indicate that the C-204 sludge also contains a solid that lacks crystalline form and is composed of Na, Al, P, O, and possibly C. Other identified solids include Fe oxides that often also contain Cr and Ni and occur as individual particles, coatings on particles, and botryoidal aggregates; a porous-looking material (or an aggregate of submicrometer particles) that typically contain Al, Cr, Fe, Na, Ni, Si, U, P, O, and C; Si oxide (probably quartz); and Na-Al silicate(s). The latter two solids probably represent minerals from the Hanford sediment, which were introduced into the tank during prior sampling campaigns or other tank operation activities. The surfaces of some Fe-oxide particles in residual solids from the water leach and selective extraction tests appear to have preferential dissolution cavities. If these Fe oxides contain contaminants of concern, then the release of these contaminants into infiltrating water would be limited by the dissolution rates of these Fe oxides, which in general have lowto very low solubilities and slow dissolution rates at near neutral to basic pH values under oxic conditions.

48 CFR 570.601 - FAR provisions and clauses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Records—Negotiation. 52.219-8Utilization of Small Business Concerns. 52.223-6Drug-Free Workplace. 52.233... participation of small disadvantaged business concerns in accordance with FAR 19.12 52.219-24Small Disadvantaged... exceeds $2,500 52.204-3Taxpayer Identification.52.219-1Small Business Program Representations. 52.222...

43 CFR 1821.10 - Where are BLM offices located?

Code of Federal Regulations, 2014 CFR

2014-10-01

..., 222 West 7th Avenue, #13, Anchorage, Alaska 99513-7599—Alaska. Arizona State Office, One North Central... Boulevard, Reno, Nevada 89502-7147, P.O. Box 12000, Reno, Nevada 89520-0006—Nevada. New Mexico State Office, 310 Dinosaur Trail, Santa Fe, NM 87508, P.O. Box 27115, Santa Fe, New Mexico 87502-0115—Kansas, New...

43 CFR 1821.10 - Where are BLM offices located?

Code of Federal Regulations, 2013 CFR

2013-10-01

..., 222 West 7th Avenue, #13, Anchorage, Alaska 99513-7599—Alaska. Arizona State Office, One North Central... Boulevard, Reno, Nevada 89502-7147, P.O. Box 12000, Reno, Nevada 89520-0006—Nevada. New Mexico State Office, 310 Dinosaur Trail, Santa Fe, NM 87508, P.O. Box 27115, Santa Fe, New Mexico 87502-0115—Kansas, New...

50 CFR 222.310 - Permit authority for designated agents and employees of specified Federal and state agencies.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., to aid stranded endangered sea turtles, and to salvage, collect data from, and dispose of, dead.... (b) If any member of any endangered species of sea turtle is found stranded or dead in the marine... such taking is necessary to aid a stranded sea turtle, or dispose of or salvage a dead sea turtle, or...

50 CFR 222.310 - Permit authority for designated agents and employees of specified Federal and state agencies.

Code of Federal Regulations, 2013 CFR

2013-10-01

..., to aid stranded endangered sea turtles, and to salvage, collect data from, and dispose of, dead.... (b) If any member of any endangered species of sea turtle is found stranded or dead in the marine... such taking is necessary to aid a stranded sea turtle, or dispose of or salvage a dead sea turtle, or...

50 CFR 222.310 - Permit authority for designated agents and employees of specified Federal and state agencies.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., to aid stranded endangered sea turtles, and to salvage, collect data from, and dispose of, dead.... (b) If any member of any endangered species of sea turtle is found stranded or dead in the marine... such taking is necessary to aid a stranded sea turtle, or dispose of or salvage a dead sea turtle, or...

40 CFR 204.54 - Test procedures.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., left, front, and back sides and top of the test unit. The microphone position to the right, left, front... calculated by the following method: L=10 log (1/5[Antilog L1/10+Antilog L 2/10+Antilog L 3/10+ Antilog L 4/10+ Antilog L 5/10]) Where: L=The average A-weighted sound level (in decibels) L 1=The A-weighted sound level...

40 CFR 204.54 - Test procedures.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., left, front, and back sides and top of the test unit. The microphone position to the right, left, front... calculated by the following method: L=10 log (1/5[Antilog L1/10+Antilog L 2/10+Antilog L 3/10+ Antilog L 4/10+ Antilog L 5/10]) Where: L=The average A-weighted sound level (in decibels) L 1=The A-weighted sound level...

Buried anode lithium thin film battery and process for forming the same

DOEpatents

Lee, Se-Hee; Tracy, C. Edwin; Liu, Ping

2004-10-19

A reverse configuration, lithium thin film battery (300) having a buried lithium anode layer (305) and process for making the same. The present invention is formed from a precursor composite structure (200) made by depositing electrolyte layer (204) onto substrate (201), followed by sequential depositions of cathode layer (203) and current collector (202) on the electrolyte layer. The precursor is subjected to an activation step, wherein a buried lithium anode layer (305) is formed via electroplating a lithium anode layer at the interface of substrate (201) and electrolyte film (204). The electroplating is accomplished by applying a current between anode current collector (201) and cathode current collector (202).

Allergenic Ingredients in Personal Hygiene Wet Wipes.

PubMed

Aschenbeck, Kelly A; Warshaw, Erin M

Wet wipes are a significant allergen source for anogenital allergic contact dermatitis. The aim of the study was to calculate the frequency of potentially allergenic ingredients in personal hygiene wet wipes. Ingredient lists from brand name and generic personal hygiene wet wipes from 4 large retailers were compiled. In the 54 personal hygiene wet wipes evaluated, a total of 132 ingredients were identified (average of 11.9 ingredients per wipe). The most common ingredients were Aloe barbadensis (77.8%), citric acid (77.8%), fragrance (72.2%), sorbic acid derivatives (63.0%), tocopherol derivatives (63.0%), glycerin (59.3%), phenoxyethanol (55.6%), disodium cocoamphodiacetate (53.7%), disodium ethylenediaminetetraacetic acid (EDTA) (42.6%), propylene glycol (42.6%), iodopropynyl butylcarbamate (40.7%), chamomile extracts (38.9%), sodium benzoate (35.2%), bronopol (22.2%), sodium citrate (22.2%), lanolin derivatives (20.4%), parabens (20.4%), polyethylene glycol derivatives (18.5%), disodium phosphate (16.7%), dimethylol dimethyl hydantoin (DMDM) (14.8%), and cocamidopropyl propylene glycol (PG)-dimonium chloride phosphate (11.1%). Of note, methylisothiazolinone (5.6%) was uncommon; methylchloroisothiazolinone was not identified in the personal hygiene wet wipes examined. There are many potential allergens in personal hygiene wet wipes, especially fragrance and preservatives.

Project Sedan, On-Site Radiological Safety Report

DTIC Science & Technology

1962-10-23

construction site between U2a & 95 U3a Complete construction area average 100 7/12/62 1530 Outside Bunker 2-300 50 7/12/62 1532 Inside Bunker 2-330 4 39...Analysis of Weather and Surface Radiation Data SC 202F Long Range Blast Propagation REECO 203F On-Site Rad-Safe AEC/ USBM 204F Structural Survey of

34 CFR 668.203 - Determining cohort default rates for institutions that have undergone a change in status.

Code of Federal Regulations, 2010 CFR

2010-07-01

... applicable to the other institution under §§ 668.204 and 668.208. (b) Acquisition or merger of institutions... participated independently in the Title IV, HEA programs immediately before the acquisition or merger— (1) For the cohort default rates published before the date of the acquisition or merger, your cohort default...

47 CFR 73.825 - Protection to reception of TV channel 6.

Code of Federal Regulations, 2013 CFR

2013-10-01

... stations authorized on TV Channel 6. FM channel number LPFM to TVchannel 6 (km) 201 98 202 97 203 95 204 94... RADIO BROADCAST SERVICES Low Power FM Broadcast Stations (LPFM) § 73.825 Protection to reception of TV channel 6. (a) LPFM stations will be authorized on Channels 201 through 220 only if the pertinent minimum...

47 CFR 73.825 - Protection to reception of TV channel 6.

Code of Federal Regulations, 2014 CFR

2014-10-01

... stations authorized on TV Channel 6. FM channel number LPFM to TVchannel 6 (km) 201 98 202 97 203 95 204 94... RADIO BROADCAST SERVICES Low Power FM Broadcast Stations (LPFM) § 73.825 Protection to reception of TV channel 6. (a) LPFM stations will be authorized on Channels 201 through 220 only if the pertinent minimum...

49 CFR 1.49 - Delegations to Federal Railroad Administrator.

Code of Federal Regulations, 2010 CFR

2010-10-01

... functions vested in the Secretary by sections 201(i)(3); 202(b)(7); 203, except authority to issue subpoenas... vested in the Secretary by sections 204(c); except authority to issue subpoenas; 402; 403; 502; 503; 504... amended, section 5 of the Department of Transportation Act (49 U.S.C. 1654), except authority to issue...

49 CFR 1.49 - Delegations to Federal Railroad Administrator.

Code of Federal Regulations, 2011 CFR

2011-10-01

... functions vested in the Secretary by sections 201(i)(3); 202(b)(7); 203, except authority to issue subpoenas... vested in the Secretary by sections 204(c); except authority to issue subpoenas; 402; 403; 502; 503; 504... amended, section 5 of the Department of Transportation Act (49 U.S.C. 1654), except authority to issue...

Transitions From Violence to Politics: Conditions for the Politicization of Violent Non-State Actors

DTIC Science & Technology

2015-12-01

jets hit PKK targets.” 203 Ibid. 204 Robin Emmott and Ayla Jean Yackley, “Turkey Erdogan says Kurdish PYD fighting Islamic State is Terror Group...December 25, 2013. http://www.bbc.com/news/world-middle- east-25515932. Emmott, Robin, and Ayla Jean Yackley. “Turkey Erdogan Says Kurdish PYD

20 CFR 429.204 - Are there any restrictions on what is allowable?

Code of Federal Regulations, 2010 CFR

2010-04-01

... disaster, theft from quarters (as limited by § 429.203(c)(1)), or under other reasonable circumstances in which it would be in the Government's best interest to make payment. In cases involving theft from quarters, the evidence must conclusively show that your quarters were locked at the time of the theft...

Environmental Law Deskbook

DTIC Science & Technology

1991-10-01

Agency FFA Federal Facilities Agreement FFCA Federal Facilities Compliance Agreement FGD Flue Gas Desulfurization FIFRA Federal Insecticide, Fungicide...carrying out response. If none, state why. EXAMPLE: Gas barriers used to control and contain vapor emissions. Runoff contained by excavating ditch...NPDES PERMITS 20-2 2006 WATER QUALITY STANDARDS 20-2 2007 POLLUTION CONTROL TECHNOLOGY 20-3 2008 TECHNOLOGY VARIANCE AND MODIFICATIONS 20-4 2009

Liability of Defense Contractors for Hazardous Waste Cleanup Costs

DTIC Science & Technology

1989-04-01

Comp. Gen. 85, 87 (1955); Johns - Manville Corp. v. United States, 12 Cl.Ct. 1, 22 (1987) (holding that ADA barred officials of the Federal Government from...building, converting, or repairing ships for the Government during World War II). 203. See, e.g., Johns - Manville Corp., 12 Cl.Ct. at 25. 204. Id. 205. Id

Neutron Capture Cross Sections of the s-Process Branching Points 147Pm, 171Tm, and 204Tl

NASA Astrophysics Data System (ADS)

Guerrero, Carlos; Domingo-Pardo, Cesar; Lerendegui-Marco, Jorge; Casanovas, Adria; Cortes-Giraldo, Miguel A.; Dressler, Rugard; Halfon, Shlomi; Heinitz, Stephan; Kivel, Niko; Köster, Ulli; Paul, Michael; Quesada-Molina, Jose Manuel; Schumann, Dorothea; Tarifeño-Saldivia, Ariel; Tessler, Moshe; Weissman, Leo

The neutron capture cross section of several key unstable isotopes acting as branching points in the s-process are crucial for stellar nucleosynthesis studies, but they are very challenging to measure due to the difficult production of sufficient sample material, the high activity of the resulting samples, and the actual (n, γ) measurement, for which high neutron fluxes and effective background rejection capabilities are required. As part of a new program to measure some of these important branching points, radioactive targets of 147Pm, 171Tm, and 204Tl have been produced by irradiation of stable isotopes (146Nd, 170Er, and 203Tl) at the Institut Laue-Langevin (ILL) high flux reactor. After breeding in the reactor and a certain cooling period, the resulting mixed 204Tl/203Tl sample was used directly while 147Pm and 171Tm were radiochemically separated in non-carrier-added quality at the Paul Scherrer Institut (PSI), then prepared as targets. A set of theses samples has been used for time-of-flight measurements at the CERN n_TOF facility using the 19 and 185 m beam lines, during 2014 and 2015. The capture cascades were detected with a set of four C6D6 scintillators, allowing to observe the associated neutron capture resonances. The results presented in this work are the first ever determination of the resonance capture cross sections of 147Pm, 171Tm, and 204Tl. Activation experiments on the same 147Pm and 171Tm targets with a high-intensity quasi-Maxwellian flux of neutrons have been performed using the SARAF accelerator and the Liquid-Lithium Target (LiLiT) in order to extract the corresponding Maxwellian Average Cross Section (MACS). The experimental setups are here described together with the first, preliminary results of the n_TOF measurement.

Integrated Advanced Microwave Sounding Unit-A (AMSU-A): Monthly Report for August

NASA Technical Reports Server (NTRS)

Nieto, A.

2000-01-01

Included in this report are Combined Program Delivery Schedules and Reports; a report from the Product Team Leaders on the status of all major program elements; Contract Data Requirements List (CDRL) 503, the Weight and Power Budgets; CDRL 204, reporting on the activities of Performance Assurance; CDRL 203, the Configuration Management Status Report; and the Documentation/Data Management Status Report.

Influence of Chronic Eicosanoid Biosynthesis Inhibition on Life History of the Greater Waxmoth, Galaleria Mellonella and Its Ectoparasitoid, Bracon hebetor

USDA-ARS?s Scientific Manuscript database

Eicosanoids are oxygenated metabolites of three C20 polyunsaturated fatty acids, mainly arachidonic acid (AA; 20:4n-6), but also 20:3n-6 and 20:5n-3. Aside from their importance in biomedicine, eicosanoids act in invertebrate biology. Prostaglandins (PGs) influence salt and water transport physiol...

Cellulosic-Derived Biofuels Program in Kentucky - Part 2

DTIC Science & Technology

2014-04-30

and lignin, are complex raw materials. Selection of robust strains of algae that are able to convert C6 (glucose) and C5 carbohydrates from...13 Task B2.03 Development of Metalloporphyrin-Ionic Liquid Complexes for Degradation of Biomass . 14 Task B2.04 –Biomass Conversion Process Scale...Up ............................................................................. 15 Task B3: Carbohydrate to Oil Conversion Process Development

Radiation Dose Deposition in the Active Marrow of Reference Man.

DTIC Science & Technology

1977-10-31

204 16 1.546E-10 .252 1,427E-10 .261 1,292E1o .273 17 1.530F-10 .237 10580E.10 9304 1.ooIEinl o272 18 9.490E11l .308 19494E-10 9249 1.3ASE-10 .268 19...IO ,269 2,399E-10 .198 29337E-10 .19217 8,124F-11 .288 1,310E-10 .?28 19331E-10 .244 18 9.013E-11 .292 2.403E-o0 . 204 2.002E-1O .199 q 7.s69E-i1 .Sl1...2.88SE-t0 viol 3,37bf-10 .155 16 1.379E-10 .227 ?.586E-i0 .179 2.030E-t0 . 204 17 2.23SEin10 .226 1.8O1E-10 .237 2,044E-10 .195 18 1.429E-I0 .?268 2367E-10

Dynamic Personal Identity and the Dynamic Identity Grid: How Theory and Concept Can Transform Information into Knowledge and Secure the American Homeland

DTIC Science & Technology

2008-09-01

Research Methods: Qualitative and Quantitative Approaches (Boston: Pearson, 2006), 1-592. 48 This project demanded the use of a primarily...enforcement practices. 200 Neuman, Social Research Methods: Qualitative and Quantitative Approaches, 152...www.socialresearchmethods.net/kb/strucres.php (accessed July 12, 2008). 203 Neuman, Social Research Methods: Qualitative and Quantitative Approaches, 149. 204 Paul

Analysis of Company Grade Officer Positions in Air Force Base Civil Engineering and Specific Recommendations for Improvement.

DTIC Science & Technology

1981-09-01

5.69 1.65 5.08 1.88 .22 2.77 .0028 98 316 54 4.52 1.68 4.01 1.95 .23 2.22 . 0132 99 317 53 5.02 1.38 4.91 1.62 .19 .58 .2810 100 318 54 4.59 1.34 4.48...RESIDUAL 272.201 127 2.143 TOTAL 424.847 176 2.414 VARIABLE 204 : Section One, Question 4 SUM OF MEAN SIGNIF SOURCE OF VARIATION SQUARES DF SQUARE F OF F...CURPOS 5.334 6 .889 .881 .511 RANK YRSRV .110 4 .028 .027 .999 RANK DEGREE 4.033 6 .672 .666 .677 CURPOS YRSRV 1.852 9 .206 . 204 .993 CURPOS DEGREE 5.028 6

Identification of a Δ5-like fatty acyl desaturase from the cephalopod Octopus vulgaris (Cuvier 1797) involved in the biosynthesis of essential fatty acids.

PubMed

Monroig, Oscar; Navarro, Juan C; Dick, James R; Alemany, Frederic; Tocher, Douglas R

2012-08-01

Long-chain polyunsaturated fatty acids (LC-PUFA) have been identified as essential compounds for common octopus (Octopus vulgaris), but precise dietary requirements have not been determined due, in part, to the inherent difficulties of performing feeding trials on paralarvae. Our objective is to establish the essential fatty acid (EFA) requirements for paralarval stages of the common octopus through characterisation of the enzymes of endogenous LC-PUFA biosynthetic pathways. In this study, we isolated a cDNA with high homology to fatty acyl desaturases (Fad). Functional characterisation in recombinant yeast showed that the octopus Fad exhibited Δ5-desaturation activity towards saturated and polyunsaturated fatty acyl substrates. Thus, it efficiently converted the yeast's endogenous 16:0 and 18:0 to 16:1n-11 and 18:1n-13, respectively, and desaturated exogenously added PUFA substrates 20:4n-3 and 20:3n-6 to 20:5n-3 (EPA) and 20:4n-6 (ARA), respectively. Although the Δ5 Fad enables common octopus to produce EPA and ARA, the low availability of its adequate substrates 20:4n-3 and 20:3n-6, either in the diet or by limited endogenous synthesis from C(18) PUFA, might indicate that EPA and ARA are indeed EFA for this species. Interestingly, the octopus Δ5 Fad can also participate in the biosynthesis of non-methylene-interrupted FA, PUFA that are generally uncommon in vertebrates but have been found previously in marine invertebrates, including molluscs, and now also confirmed to be present in specific tissues of common octopus.

77 FR 23803 - Office of Hazardous Materials Safety; Actions on Special Permit Applications

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-20

... MODIFICATION SPECIAL PERMIT GRANTED 8826-M Phoenix Air 49 CFR 172.101; To modify the Group, Inc. 172.204(c)(3...-M......... Conference of 49 CFR To modify the Radiation 172.203(d); special permit add Control Part............ Conference of 49 CFR Part To modify the Radiation 172, Subparts, special permit add Control C, D, E, F, G, 49...

Identifying sources of Pb pollution in urban soils by means of MC-ICP-MS and TOF-SIMS.

PubMed

Rodríguez-Seijo, Andrés; Arenas-Lago, Daniel; Andrade, María Luisa; Vega, Flora A

2015-05-01

Lead pollution was evaluated in 17 urban soils from parks and gardens in the city of Vigo (NW Spain). The Pb isotope ratios ((207)Pb/(206)Pb, (208)Pb/(204)Pb, (206)Pb/(204)Pb and (208)Pb/(206)Pb) were determined after being measured by MC-ICP-MS. The association of the isotopes ((204)Pb, (206)Pb, (207)Pb and (208)Pb) with the different components of the soil was studied using TOF-SIMS. The isotopic ranges obtained for the samples were between 1.116 and 1.203 ((206)Pb/(207)Pb), 2.044-2.143 ((208)Pb/(206)Pb), 37.206-38.608 ((208)Pb/(204)Pb), 15.5482-15.6569 ((207)Pb/(204)Pb) and 17.357-18.826 ((206)Pb/(204)Pb). The application of the three-end-member model indicates that the Pb derived from petrol is the main source of Pb in the soils (43.51% on average), followed by natural or geogenic Pb (39.12%) and industrial emissions (17.37%). The emissions derived from coal combustion do not appear to influence the content of Pb in the soil. TOF-SIMS images show that the Pb mainly interacts with organic matter. This technique contributes to the understanding of the association of anthropogenic Pb with the components of the soil, as well as the particle size of these associations, thus allowing the possible sources of Pb to be identified.

The Caribbean Basin: A Climatological Study

DTIC Science & Technology

1989-12-01

40 to200 km). A ridge in the center of theislanrises toI 1,017 feet (310 meters), but most of the island is mangrove swamp. The Isle of Pines (or Isle...The highest port of Plymouth . The southern range rises to 3,000 feet (914 point is 669 feet (204 meters). meters) in the Soufriere Hills. LES SAINTES...and de Margarita aft. from west to est: Islas de Ayes, Islas Ins barren . r; -ing from sea level to 617 feet (188 metes). Roques. La Orchila, Isla Is

Assessment of the efficacy and safety of eslicarbazepine acetate in acute mania and prevention of recurrence: experience from multicentre, double-blind, randomised phase II clinical studies in patients with bipolar disorder I.

PubMed

Grunze, Heinz; Kotlik, Eduardo; Costa, Raquel; Nunes, Teresa; Falcão, Amílcar; Almeida, Luis; Soares-da-Silva, Patrício

2015-03-15

Eslicarbazepine acetate (ESL) is an anticonvulsant approved as an adjunctive therapy in adults with partial-onset seizures. To evaluate the efficacy, safety and tolerability of ESL in the treatment of acute mania and prevention of recurrence in bipolar disorder I. Two 3-week multicentre, double-blind, randomised, placebo-controlled studies in acute mania (study BIA-2093-203: dose titrated by response, ESL 600-1800mg or 800-2400mg, once-daily; study BIA-2093-204: fixed doses of 600, 1200 and 1800mg, once-daily) were followed by a recurrence prevention study consisting of a 2-week open-label period (900mg, once-daily) continued by a double-blind, parallel-group, fixed dose (300, 900 and 1800mg, once-daily) period for a minimum of 6 months. The primary endpoint was changed from baseline until the end of the 3-week treatment period in Young Mania Rating Scale (YMRS) in studies BIA-2093-203 and BIA-2093-204, and the proportion of patients showing no worsening according to the Clinical Global Impressions - Bipolar Version (CGI-BP) over Part II in study BIA-2093-205. In study BIA-2093-203 (n=160, ITT), neither dose group was statistically different from placebo in the primary endpoint, though the ESL 800-2400mg showed a greater reduction in YMRS score (p=0.0523). CGI-BP score changes for mania and overall bipolar illness indicate a significant improvement in patient symptomatology for the ESL 800-2400mg group (from preceding and worst phase) and for ESL 600-1800mg group (from worst phase only) when compared to placebo. Study BIA-2093-204 (n=38) results were inconclusive due to premature termination caused by recruitment difficulties. In study BIA-2093-205 (n=85, ITT), at least 50% of patients showed no worsening in all treatment groups (p=0.250). ESL adverse events were mostly of mild and moderate intensities and consistent with previously reported observations for ESL. ESL treatment was not significantly different from placebo in manic patients in the primary outcome, but secondary outcomes may be suggestive of efficacy. The recurrence prevention study provides preliminary support for efficacy of ESL in patients recovered from an acute manic episode. Copyright © 2014 Elsevier B.V. All rights reserved.

Evaluation of Safety Programs with Respect to the Causes of General Aviation Accidents. Volume I. Technical Report,

DTIC Science & Technology

1980-05-01

65 Physical Impairment 66 Spatial disorientation. 67 Psychological condition. 71 Misused or failed to use flaps. 74 Left aircraft unattended, engine...ARTS III - (Software) (1975) 203 Weather Radar Display System (ASR - 57) 204 ATARS - Automated Terminal Area Radar Service (1974) 205 Instrument Landing...Generated Trauma, Pathological and Psychological Dysfunction accident causes. Collectively, the distribution of safety programs throughout the fault

Learning Preference Models for Autonomous Mobile Robots in Complex Domains

DTIC Science & Technology

2010-12-01

van Niekerk, E. Jensen, P. Alessandrini, G. Bradski, B. Davies, S. Ettinger, A. Kaehler, A. Nefian, and P. Mahoney , “Stanley: The robot that won the...Learning, vol. 24, pp. 123–140, 1996. 137 [277] L. Murphy and P. Newman , “Planning most-likely paths from overhead imagery,” in Inter- national Conference...B. [150] Nashman, M. [64] Nehmzow, U. [265, 266] Neto, H. [265] Newman , P. [277] Ng, A. Y. [199, 203, 222, 223, 241–243, 254] Nguyen, T. [115] Niekum

Combinatorial Problems of Applied Discrete Mathematics.

DTIC Science & Technology

1979-12-01

204 .I (30) 3. Steiner, Combinatorische Aufgabe, Z. Reine Angew. Math. 45 (1853) 18 1—182. (31) IC. Takeuchi, A table of difference sets generating...Assoc. Fr. Ay. Sd . 1 (1900) 122— 123; 2 (1901) 170—203. • (33) R.M. Wilson, Cyclotomy and difference fam ilies in elementary Abelian groups , 3. Number...the differe nt cliques containing either A or B. Let us first introduce the following notations. If A is a vertex in G, then 1(A) denotes the set of

A Double Decarboxylation in Superfolder Green Fluorescent Protein Leads to High Contrast Photoactivation.

PubMed

Slocum, Joshua D; Webb, Lauren J

2017-07-06

A photoactivatable variant of superfolder green fluorescent protein (GFP) was created by replacing the threonine at position 203 with aspartic acid. Photoactivation by exposure of this mutant to UV light resulted in conversion of the fluorophore from the neutral to the negatively charged form, accompanied by a ∼95-fold increase in fluorescence under 488 nm excitation. Mass spectrometry before and after exposure to UV light revealed a change in mass of 88 Da, attributed to the double decarboxylation of Glu 222 and Asp 203. Kinetics studies and nonlinear power-dependence of the initial rate of photoconversion indicated that the double decarboxylation occurred via a multiphoton absorption process at 254 nm. In addition to providing a photoactivatable GFP with robust folding properties, a detailed mechanistic understanding of this double decarboxylation in GFP will lead to a better understanding of charge transfer in fluorescent proteins.

Computer Control and Activation of Six-Degree-of-Freedom Simulator

DTIC Science & Technology

1983-01-01

Evaluation of Matrices 54 Calculation of Linear Coefficients 54 Off-Line Calculations for Aircraft 59 Off-Line Calculations for Combat Vehicle 61 Table...468 in. 59 Physical concept tail-boom control system 203 Vlll 60 Tail-boom control system block diagram 204 61 Block diagram for position...configuration. Now, since Z must be diagonal, it follows that the principal elements of Z are given by 13 where and a) = ^11 ^12’ 2 2 ^21 ^22 ’ 61

Major Rehabilitation Effort, Mississippi River, Locks and Dams 2-22: Illinois Waterway from LA Grange to Lockport Locks and Dams: Iowa, Illinois, Missouri, Minnesota and Wisconsin.

DTIC Science & Technology

1989-03-01

provided helper boats are a viable, but expensive, alternative Bow boats or bow thrusters are not likely to be put into wide service on the UMRS Improved... thrusters are even smaller, lower-horsepower units, which provide the same basic function as bowboats, but cannot be independently operated and require...other mammals depend on these areas. Marsh vegetation produce and sustain higher numbers of wildlife than any other land category. 3.10 and and - Sand

20. Streetscape, South Coronado Boulevard, looking southwest Righttoleft, AZ198(Margaret B. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

20. Streetscape, South Coronado Boulevard, looking southwest Right-to-left, AZ-198(Margaret B. Hill House), AZ-199 (Henry H. Hill House), AZ-200 (Henry H. Hill Rental House), AZ-201 (Otto Rosenthal House), AZ-202 (J. M. Stevens House), AZ-203 (L J. Dunagan House), AZ204 (C. W. Beck House), and AZ-205 (F. D. Connor House) face the street - Clifton Townsite, Confluence of Chase Creek & San Francisco River, Clifton, Greenlee County, AZ

Leadex Data Report. Part 2. Rawinsonde and Ice Station Data

DTIC Science & Technology

1992-12-01

Jke Camp (24 Apr 92) Ic Camp (2 Mar 92) ISO I" *".8BEAUFORT Figure 1. Leadex Locator Chart with Location of Ice Camp at Beginning and Ending of Leadex...267 23.7 0 36 15 7388 360.0 262 27.0 F 43 15 8882 285 1 257 20.4 D Ś 20 9549 256.9 240 21.0 D 50 35 10469 222.8 250 15.2 0 54 45 11352 194.5 230

PREDICTION OF VO2PEAK USING OMNI RATINGS OF PERCEIVED EXERTION FROM A SUBMAXIMAL CYCLE EXERCISE TEST

PubMed Central

Mays, Ryan J.; Goss, Fredric L.; Nagle-Stilley, Elizabeth F.; Gallagher, Michael; Schafer, Mark A.; Kim, Kevin H.; Robertson, Robert J.

2015-01-01

Summary The primary aim of this study was to develop statistical models to predict peak oxygen consumption (VO2peak) using OMNI Ratings of Perceived Exertion measured during submaximal cycle ergometry. Men (mean ± standard error: 20.90 ± 0.42 yrs) and women (21.59 ± 0.49 yrs) participants (n = 81) completed a load-incremented maximal cycle ergometer exercise test. Simultaneous multiple linear regression was used to develop separate VO2peak statistical models using submaximal ratings of perceived exertion for the overall body, legs, and chest/breathing as predictor variables. VO2peak (L·min−1) predicted for men and women from ratings of perceived exertion for the overall body (3.02 ± 0.06; 2.03 ± 0.04), legs (3.02 ± 0.06; 2.04 ± 0.04) and chest/breathing (3.02 ± 0.05; 2.03 ± 0.03) were similar with measured VO2peak (3.02 ± 0.10; 2.03 ± 0.06, ps > .05). Statistical models based on submaximal OMNI Ratings of Perceived Exertion provide an easily administered and accurate method to predict VO2peak. PMID:25068750

Surface-Finish Measurement with Interference Microscopes,

DTIC Science & Technology

1977-02-01

Microscope 17 Multiple-Beam Interference Microscope .. 25 Fringes of Equal Chromatic Order 27 Nomarski Polarization-Contrast Technique 33...characteristics of each instrument: the double and multiple-beam interferometer, the FECO fringe interferometer, and the Nomarski polarization contrast...328X Beam Reichert 8X 0.15 2.22 87 33X Nomarski 16X 0.25 1.33 52 55X 203X Technique 32X 0.40 0.83 33 87X 395X 45 X 0.65 0.51 20 142X 567 X 80X

Project Sedan Event, July 6, 1962

DTIC Science & Technology

1962-12-12

Queen City Summit over Highway 25 14 1532 358 68 300 32 miles NW of Queen City Summit over Highway 25 14 1534 357 69 300 36 miles NW of Queen City...Blast Propagation REECO 203F On-Site Rad-Safe AEC/ USBM 204F Structural Survey of Private Mining Opera- tions FAA 205F Airspace Closure SC 211F Close-In...Weather Bureau, Las Vegas, Nevada USBM U. S. Bureau of Mines, Washington, D. C. FAA Federal Aviation Agency, Salt Lake City, Utah REECO Reynolds

Psychometrics of the neonatal oral motor assessment scale.

PubMed

Zarem, Cori; Kidokoro, Hiroyuki; Neil, Jeffrey; Wallendorf, Michael; Inder, Terrie; Pineda, Roberta

2013-12-01

To establish the psychometrics of the Neonatal Oral Motor Assessment Scale (NOMAS). In this prospective cohort study of 75 preterm infants (39 females, 36 males) born at or before 30 weeks gestation (mean gestational age 26.56 wks, SD 1.90, range 23-30 wks; mean birthweight 967.33 g, SD 288.54, range 480-2240), oral feeding was videotaped before discharge from the neonatal intensive care unit (NICU). The NOMAS was used to classify feeding as normal, disorganized, or dysfunctional. Neurobehavior was assessed at term equivalent, and infants underwent magnetic resonance imaging. Children returned for developmental testing at 2 years corrected age. Associations between NOMAS scores and (1) neurobehavior; (2) cerebral injury and metrics; and (3) developmental outcome were investigated using χ(2) -analyses, t-tests, and linear regression. For reliability, six certified NOMAS evaluators rated five randomly selected NOMAS recordings and re-scored them 2 weeks later in a second randomized order. Reliability was calculated with Cohen's kappa statistics. Dysfunctional NOMAS scores were associated with lower Dubowitz scores [t=-2.14; mean difference -2.32 (95% confidence interval [CI] -0.157 to -4.49); p=0.036], higher stress on the NICU Network Neurobehavioral Scale (t=2.61; mean difference 0.073 [95% CI 0.017-0.129]; p=0.0110), and decreased transcerebellar diameter (t=-2.22; mean difference -2.04 [CI=-3.89 to -0.203]; p=0.03). No significant associations were found between NOMAS scores and 2-year outcome. Some concurrent validity was established with associations between NOMAS scores and measures of infant behavior and cerebral structure. The NOMAS did not show predictive validity in this study of preterm infants at high risk of developmental delay. Reliability was variable and suboptimal. © 2013 Mac Keith Press.

Psychometrics of the neonatal oral motor assessment scale

PubMed Central

Zarem, Cori S; Kidokoro, Hiroyuki; Neil, Jeffrey; Wallendorf, Michael; Inder, Terrie; Pineda, Roberta

2013-01-01

AIM To establish the psychometrics of the Neonatal Oral Motor Assessment Scale (NOMAS). METHOD In this prospective cohort study of 75 preterm infants (39 females,36 males) born at 30 weeks' or less gestation (mean gestational age 26.56wk, SD 1.90, range 23–30wk; mean birthweight 967.33g, SD 288.54, range 480–2240), oral feeding was videotaped before discharge from the neonatal intensive care unit (NICU) discharge. The NOMAS was used to classify feeding as normal, disorganized, or dysfunctional. Neurobehavior was assessed at term equivalent, and infants underwent magnetic resonance imaging. Children returned for developmental testing at 2 years corrected age. Associations between NOMAS scores and (1) neurobehavior, (2) cerebral injury and metrics, and (3) developmental outcome were investigated using χ2-analyses, t-tests, and linear regression. For reliability, six certified NOMAS evaluators rated five randomly selected NOMAS recordings and re-scored them in a second randomized order. Reliability was calculated with Cohen’s kappa coefficient. RESULTS Dysfunctional NOMAS scores were associated with lower Dubowitz scores [t=–2.14; mean difference –2.32 (95% confidence interval [CI] –0.157 to –4.49); p=0.036], higher stress on the NICU Network Neurobehavioral Scale (t=2.61; mean difference 0.073 [95% CI 0.017 to 0.129]; p=0.0110, and decreased transcerebellar diameter (t=–2.22; mean difference –2.04 [CI=–3.89 to –0.203]; p=0.03). No significant associations were found between NOMAS scores and 2 year outcome. INTERPRETATION Some concurrent validity was established with associations between NOMAS scores and measures of infant behavior and cerebral structure. The NOMAS did not show predictive validity in this study of preterm infants at high risk of developmental delay. Reliability was variable and suboptimal. PMID:23869958

2017 Global Explosive Ordnance Disposal (EOD) Symposium and Exhibition. Held in North Bethesda, MD on 8-9 August 2017.

DTIC Science & Technology

2017-08-09

Commander, Israeli National Police Bomb Squad, Senior CIED Analyst & Author, Mobius Reports 9:00 AM - 6:30 PM Exhibit Hall Open Salons A-E 9:30 AM...Operation Inherent Resolve • COL Frank Davis, USA, Commander, 71st EOD Group 9:00 AM - 9:45 AM Belgium Bombing of 22 March 2016 Briefing • Commander...SYNEXXUS 201 United States Bomb Technician Association 202 55th Ordnance Company (EOD) 203 RE2 Robotics 204 W.S. Darley & Company 207 Roboteam Inc. 210

Ultrafast and low barrier motions in the photoreactions of the green fluorescent protein.

PubMed

van Thor, Jasper J; Georgiev, Georgi Y; Towrie, Michael; Sage, J Timothy

2005-09-30

Green fluorescent protein (GFP) fluoresces efficiently under blue excitation despite major electrostatic rearrangements resulting from photoionization of the chromophore and neutralization of Glu-222. A competing phototransformation process, which ionizes the chromophore and decarboxylates Glu-222, mimics the electrostatic and structural changes in the fluorescence photocycle. Structural and spectroscopic analysis of the cryogenically stabilized photoproduct at 100 K and a structurally annealed intermediate of the phototransformed protein at 170 K reveals distinct structural relaxations involving protein, chromophore, solvent, and photogenerated CO2. Strong structural changes of the 100 K photoproduct after decarboxylation appear exclusively within 15 angstroms of the chromophore and include the electrostatically driven perturbations of Gln-69, Cys-70, and water molecules in an H-bonding network connecting the chromophore. X-ray crystallography to 1.85 angstroms resolution and static and picosecond time-resolved IR spectroscopy identify structural mechanisms common to phototransformation and to the fluorescence photocycle. In particular, the appearance of a 1697 cm(-1) (+) difference band in both photocycle and phototransformation intermediates is a spectroscopic signature for the structural perturbation of Gln-69. This is taken as evidence for an electrostatically driven dynamic response that is common to both photoreaction pathways. The interactions between the chromophore and the perturbed residues and solvent are decreased or removed in the T203H single and T203H/Q69L double mutants, resulting in a strong reduction of the fluorescence quantum yield. This suggests that the electrostatic response to the transient formation of a buried charge in the wild type is important for the bright fluorescence.

Estimation of supersonic fighter jet airfoil data and low speed aerodynamic analysis of airfoil section at the Mach number 0.15

NASA Astrophysics Data System (ADS)

Sogukpinar, Haci

2018-02-01

In this paper, some of the NACA 64A series airfoils data are estimated and aerodynamic properties are calculated to facilitate great understandings effect of relative thickness on the aerodynamic performance of the airfoil by using COMSOL software. 64A201-64A204 airfoils data are not available in literature therefore 64A210 data are used as reference data to estimate 64A201, 64A202, 64A203, 64A204 airfoil configurations. Numerical calculations are then conducted with the angle of attack from -12° to +16° by using k-w turbulence model based on the finite-volume approach. The lift and drag coefficient are one of the most important parameters in studying the airplane performance. Therefore lift, drag and pressure coefficient around selected airfoil are calculated and compared at the Reynolds numbers of 6 × 106 and also stalling characteristics of airfoil section are investigated and presented numerically.

Logistics Handbook for Strategic Mobility Planning

DTIC Science & Technology

1992-09-01

242 181 79 184 MASSACHUSETTS Fort Devens 69 88 204 212 213 261 297 389 549 Hanscom AFB 55 66 214 222 223 271 304 399 556 S Weymouth NAS 43 63 219 227...1015 962 Pax River NAS 366 389 516 701 590 724 1054 11009 964 MASSACHUSETTS Fort Devens 786 809 938 1123 1012 1158 1476 1432 1379 HanscomAFB 796 819 948...1715 Castle AFB 2212 2213 2180 2130 1901 1880 1843 1793 1751 Fort Baker 2329 2330 2297 2258 2004 1983 1946 1896 1854 Fort H. Liggett 2265 2266 2219

AmeriFlux US-Me5 Metolius-first young aged pine

DOE Data Explorer

Law, Bev [Oregon State University

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site US-Me5 Metolius-first young aged pine. Site Description - Previously old-growth ponderosa pine, clearcut in 1978 and allowed to regenerate naturally. Law et al (2001) Global Change Biology 7, 755-777; Law et al (2001) Agricultural and Forest Meteorology 110, 27-43; Anthoni et al (2002) Agricultural and Forest Meteorology 111, 203-222; Irvine & Law (2002) Global Change biology 8,1183-1194, Irivne et al (2004) Tree Physiology 24,753-763.

Deficiency of long-chain polyunsaturated fatty acids in phenylketonuria: a cross-sectional study.

PubMed

Drzymała-Czyż, Sławomira; Kałużny, Łukasz; Krzyżanowska-Jankowska, Patrycja; Walkowiak, Dariusz; Mozrzymas, Renata; Walkowiak, Jarosław

2018-01-01

The etiology of altered blood fatty acid (FA) profile in phenylketonuria (PKU) is understood only partially. We aimed to determine whether FAs deficiency is dependent on the diet or metabolic disturbances. The study comprised 40 PKU patients (20 female, 20 male; aged 11 to 35 years; 12 children and 28 adults) and 40 healthy subjects (HS; 20 female, 20 male, aged 18 to 33 years). We assessed the profile of FAs (gas chromatography/mass spectrometry) and analyzed the 72-hour dietary recalls. The amount of C14:0, C16:0 and C16:1n-7, C18:1n-9 did not differ between the analyzed groups. The percentage of C18:0 was higher, while C20:3n-9, C18:2n-6, C20:2n-6, C20:4n-6, C22:4n-6, C22:5n-6 and C22:6n-3 was lower in PKU than in HS. However, C18:3n-6, C18:3n-3 and n-6/n-3 ratio were higher in PKU patients. The C20:4n-6/C20:3n-6 ratio (reaction catalyzed by Δ5-desaturase), the C22:5n-6/C22:4n-6 and the C22:6n-3/C22:5n-3 ratio (both reactions catalyzed by Δ6 desaturase) were significantly lower in PKU patients. Therefore, the deficiency of long-chain polyunsaturated fatty acids in PKU patients may result not only from inadequate supply but also from metabolic disturbances.

Prediction of Backscatter and Emissivity of Snow at Millimeter Wavelengths.

DTIC Science & Technology

1980-01-01

LIST OF FIGURES Figure Title Page C-I General Area Map 204 C-2 Location of Alpena National Weather 205 Service Station C-3 Photographs of Site E 206 C-4...February 5, 6, 7, 1979 were ob- tained from National Weather Service, Alpena Station and included in Tables C-9 through C-12. Figure C-2 shows the...relative position * 1 of the sites and the Alpena National Weather Service Station. 203 I 0 1 s LAKE HURON ROGERS CITY 20 0 5 10 MILES 0 C HEBOYGAN NORTH

A rapid novel derivatization of amphetamine and methamphetamine using 2,2,2-trichloroethyl chloroformate for gas chromatography electron ionization and chemical ionization mass spectrometric analysis.

PubMed

Dasgupta, A; Spies, J

1998-05-01

Amphetamine and methamphetamine are commonly abused central nervous system stimulants. We describe a rapid new derivatization of amphetamine and methamphetamine using 2,2,2-trichloroethyl chloroformate for gas chromatography-mass spectrometric analysis. Amphetamine and methamphetamine, along with N-propyl amphetamine (internal standard), were extracted from urine using 1-chlorobutane. The derivatization with 2,2,2-trichloroethyl chloroformate can be achieved at room temperature in 10 minutes. The electron ionization mass spectrum of amphetamine 2,2,2-trichloroethyl carbamate showed two weak molecular ions at m/z 309 and 311, but showed diagnostic strong peaks at m/z 218, 220, and 222. In contrast, chemical ionization of the mass spectrum of amphetamine 2,2,2-trichloroethyl carbamate showed strong (M + 1) ions at m/z 310 and 312 and other strong diagnostic peaks at m/z 274 and 276. The major advantages of this derivative are the presence of a diagnostic cluster of peaks due to the isotopic effect of three chlorine atoms (isotopes 35 and 37) in the derivatized molecule and the relative ease of its preparation. We also observed strong molecular ions for derivatized methamphetamine in the chemical ionization mass spectrum, but the molecular ions were very weak in the electron ionization mass spectrum. We used the scan mode of mass spectrometry in all analyses. When using a urine standard containing 1,000 ng/mL of amphetamine (a 7.4-micromol/L concentration) and methamphetamine (a 6.7-micromol/L concentration), the within-run precisions were 4.8% for amphetamine and 3.6% for methamphetamine. The corresponding between-run precisions were 5.3% for amphetamine and 6.7% for methamphetamine. The assay was linear for amphetamine and methamphetamine concentrations of 250 to 5,000 ng/mL (amphetamine, 1.9-37.0 micromol/L; methamphetamine, 1.7-33.6 micromol/L). The detection limit was 100 ng/mL (amphetamine, 0.74 micromol/L; methamphetamine, 0.67 micromol/L) using the scan mode of electron ionization mass spectrometry. We observed good a correlation between the concentrations of amphetamine and methamphetamine in five urine specimens positive for amphetamines using the more conventional pentafluoropropionyl derivative and our new derivative using 2,2,2-trichloroethyl chloroformate.

40 CFR 466.33 - New source performance standards.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 6.13 0.79 Oil and grease 97.24 12.60 97.24 12.60 TSS 145.86 18.91 116.69 15.12 pH (1) (1) (1) (1... 0.03 0.18 0.20 Nickel 1.10 0.14 0.74 0.10 Zinc 2.03 0.27 0.84 0.11 Aluminum 6.03 0.78 2.47 0.32 Iron 2.45 0.32 1.26 0.16 Oil and grease 19.92 2.58 19.92 2.58 TSS 29.88 3.87 23.90 3.10 pH (1) (1) (1) (1...

40 CFR 466.33 - New source performance standards.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 6.13 0.79 Oil and grease 97.24 12.60 97.24 12.60 TSS 145.86 18.91 116.69 15.12 pH (1) (1) (1) (1... 0.03 0.18 0.20 Nickel 1.10 0.14 0.74 0.10 Zinc 2.03 0.27 0.84 0.11 Aluminum 6.03 0.78 2.47 0.32 Iron 2.45 0.32 1.26 0.16 Oil and grease 19.92 2.58 19.92 2.58 TSS 29.88 3.87 23.90 3.10 pH (1) (1) (1) (1...

40 CFR 466.33 - New source performance standards.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 6.13 0.79 Oil and grease 97.24 12.60 97.24 12.60 TSS 145.86 18.91 116.69 15.12 pH (1) (1) (1) (1... 0.03 0.18 0.20 Nickel 1.10 0.14 0.74 0.10 Zinc 2.03 0.27 0.84 0.11 Aluminum 6.03 0.78 2.47 0.32 Iron 2.45 0.32 1.26 0.16 Oil and grease 19.92 2.58 19.92 2.58 TSS 29.88 3.87 23.90 3.10 pH (1) (1) (1) (1...

Frequency of and risk factors for symptomatic bone fractures in patients with systemic lupus erythematosus.

PubMed

Ekblom-Kullberg, S; Kautiainen, H; Alha, P; Leirisalo-Repo, M; Julkunen, H

2013-01-01

To study risk factors for symptomatic bone fractures in patients with systemic lupus erythematosus (SLE) and to compare the frequency of fractures between SLE patients and population controls. The study included 222 SLE patients [mean age 47.0 years, disease duration 13.1 years, 204 (92%) women] and 720 population controls living in the metropolitan area of Helsinki. The history of symptomatic bone fractures in SLE patients and controls was recorded by interview, and demographic and clinical data of SLE patients were obtained by interview, clinical examination, and chart review. A history of at least one symptomatic bone fracture was recorded in 93 (42%) of all 222 patients with SLE. The risk of any fracture in 204 women with SLE compared to controls was 1.8 [95% confidence interval (CI) 1.3-2.4] and fractures in the ankle, hip, and vertebral column were more common than in female controls, with odds ratios (ORs) of 2.0 (95% CI 1.1-3.7), 5.1 (95% CI 1.2-21.5), and 4.0 (95% CI 1.8-8.6), respectively. In 18 men with SLE, compared to male controls, no difference in the frequency of fractures was observed (OR 0.7, 95% CI 0.3-2.0). Risk factors for bone fractures in women with SLE were age (p = 0.008), comorbidity (p = 0.050), and the duration of corticosteroid use (p = 0.025). Symptomatic bone fractures, especially in the ankle, hip, and vertebral column, are common in women with SLE. Special attention should be paid to preventing fractures in elderly female patients with comorbidities and a long duration of corticosteroid use.

Comparison of rhizosphere properties as affected by different Bt- and non-Bt-cotton (Gossypium hirsutum L.) genotypes and fertilization.

PubMed

Ahamd, Maqshoof; Abbasi, Waleed Mumtaz; Jamil, Moazzam; Iqbal, Muhammad; Hussain, Azhar; Akhtar, Muhammad Fakhar-U-Zaman; Nazli, Farheen

2017-06-01

Incorporation of genetically modified crops in the cropping system raises the need for studying the effect of these crops on the soil ecosystem. The current study aimed to compare the effect of Bacillus thuringiensis (Bt)- and non-Bt-cotton (Gossypium hirsutum L.) genotypes on rhizosphere properties under fertilized and unfertilized soil conditions. One non-Bt-cotton (IUB 75) and four Bt-cotton varieties (IUB-222, MM-58, IUB-13, FH-142) were sown in a Randomized Complete Block Design (RCBD) in a factorial fashion with three replications under unfertilized (T1) and fertilized (T2 at NPK 310-170-110 kg ha -1 ) soil conditions. The culturable soil bacterial population was recorded at flowering, boll opening, and harvesting stages, while other rhizosphere biological and chemical properties were recorded at harvesting. Results revealed that Bt-cotton genotypes IUB-222 and FH-142 showed significantly higher rhizosphere total nitrogen, NH 4 + -N, available phosphorus, and available potassium. Total organic carbon and microbial biomass carbon was also maximum in the rhizosphere of IUB-222 under fertilized conditions. Similarly, bacterial population (CFU g -1 ) at flowering stage and at harvesting was significantly higher in the rhizosphere of IUB-222 as compared to non-Bt- (IUB-75) and other Bt-cotton genotypes under same growth conditions. It showed that Bt genotypes can help in maintaining soil macronutrients (total nitrogen, available phosphorus, and available potassium) under proper nutrient management. Moreover, Bt-cotton genotypes seem to strengthen certain biological properties of the soil, thus increasing the growth and yield capability, maintaining available nutrients in the soil as compared to non-Bt cotton, while no harmful effects of Bt cotton on soil properties was detected.

A Systems Analysis View of the Vietnam War: 1965-1972. Volume 8. Casualties and Losses

DTIC Science & Technology

1975-02-18

e~d th2 offer of GVN cl,411!ai and militarry carzerb positions cm-paxrable to those held blr defectors in enem ~y orgaIizutioas. G VTI officlials...15 2 03212 . . sa11314 1381 2018 1561 -203h. 15714 .11435 119W .1279 * NOV* 28 41 50’ 53 `117 86 123 -86- 1014’ UmC 655 586 122 9r. m 217k 926 1262...1021. n05 .3%1..414 .66 78 85.1’ e6-.136* 194- -136. 250 * ’ usm 606, 51.531136 908 2018 861 1171 1028 21429 twota .16 14114. 22. 0 3.10

EPA, DHA, and Lipoic Acid Differentially Modulate the n-3 Fatty Acid Biosynthetic Pathway in Atlantic Salmon Hepatocytes.

PubMed

Bou, Marta; Østbye, Tone-Kari; Berge, Gerd M; Ruyter, Bente

2017-03-01

The aim of the present study was to investigate how EPA, DHA, and lipoic acid (LA) influence the different metabolic steps in the n-3 fatty acid (FA) biosynthetic pathway in hepatocytes from Atlantic salmon fed four dietary levels (0, 0.5, 1.0 and 2.0%) of EPA, DHA or a 1:1 mixture of these FA. The hepatocytes were incubated with [1- 14 C] 18:3n-3 in the presence or absence of LA (0.2 mM). Increased endogenous levels of EPA and/or DHA and LA exposure both led to similar responses in cells with reduced desaturation and elongation of [1- 14 C] 18:3n-3 to 18:4n-3, 20:4n-3, and EPA, in agreement with reduced expression of the Δ6 desaturase gene involved in the first step of conversion. DHA production, on the other hand, was maintained even in groups with high endogenous levels of DHA, possibly due to a more complex regulation of this last step in the n-3 metabolic pathway. Inhibition of the Δ6 desaturase pathway led to increased direct elongation to 20:3n-3 by both DHA and LA. Possibly the route by 20:3n-3 and then Δ8 desaturation to 20:4n-3, bypassing the first Δ6 desaturase step, can partly explain the maintained or even increased levels of DHA production. LA increased DHA production in the phospholipid fraction of hepatocytes isolated from fish fed 0 and 0.5% EPA and/or DHA, indicating that LA has the potential to further increase the production of this health-beneficial FA in fish fed diets with low levels of EPA and/or DHA.

Integrated Advanced Microwave Sounding Unit-A (AMSU-A)

NASA Technical Reports Server (NTRS)

Hauerwaas, R.

1998-01-01

This is the 69th Monthly Report for the Advanced Microwave Sounding Unit-A (EOS/AMSU-A), Contract NAS5-32314, and covers the period from 01 September through 30 September 1998. Included in this report are Combined Program Delivery Schedules and Reports (Section 2); a report from the Product Team Leaders on the status of all major program elements (Section 3); Contract Data Requirements List (CDRL) 503, the Weight and Power Budgets (Section 5); CDRL 204, reporting on the activities of Performance Assurance (Section 6); CDRL 203, the Configuration Management Status Report (Section 7); and the Document/Data Management Status Report (Section 8).

Shedding light on the mercury mass discrepancy by weighing Hg 52+ ions in a Penning trap

NASA Astrophysics Data System (ADS)

Fritioff, T.; Bluhme, H.; Schuch, R.; Bergström, I.; Björkhage, M.

2003-07-01

In their nuclear tables Audi and Wapstra have pointed out a serious mass discrepancy between their extrapolated values for the mercury isotopes and those from a direct measurement by the Manitoba group. The values deviate by as much as 85 ppb from each other with claimed uncertainties of about 16 and 7 ppb, respectively. In order to decide which values are correct the masses of the 198Hg and 204Hg isotopes have been measured in the Stockholm Penning trap mass spectrometer SMILETRAP using 52+ ions. This charge state corresponds to a filled Ni electron configuration for which the electron binding energy can be accurately calculated. The mass values obtained are 197.966 768 44(43) u for 198Hg and 203.973 494 10(39) u for 204Hg. These values agree with those measured by the Manitoba group, with a 3 times lower uncertainty. This measurement was made possible through the implementation of a cooling technique of the highly charged mercury ions during charge breeding in the electron beam ion source used for producing the Hg 52+ ions.

Effects of Cavities at the Nicotinamide Binding Site of Liver Alcohol Dehydrogenase on Structure, Dynamics and Catalysis

PubMed Central

2015-01-01

A role for protein dynamics in enzymatic catalysis of hydrogen transfer has received substantial scientific support, but the connections between protein structure and catalysis remain to be established. Valine residues 203 and 207 are at the binding site for the nicotinamide ring of the coenzyme in liver alcohol dehydrogenase and have been suggested to facilitate catalysis with “protein-promoting vibrations” (PPV). We find that the V207A substitution has small effects on steady-state kinetic constants and the rate of hydrogen transfer; the introduced cavity is empty and is tolerated with minimal effects on structure (determined at 1.2 Å for the complex with NAD+ and 2,3,4,5,6-pentafluorobenzyl alcohol). Thus, no evidence is found to support a role for Val-207 in the dynamics of catalysis. The protein structures and ligand geometries (including donor–acceptor distances) in the V203A enzyme complexed with NAD+ and 2,3,4,5,6-pentafluorobenzyl alcohol or 2,2,2-trifluoroethanol (determined at 1.1 Å) are very similar to those for the wild-type enzyme, except that the introduced cavity accommodates a new water molecule that contacts the nicotinamide ring. The structures of the V203A enzyme complexes suggest, in contrast to previous studies, that the diminished tunneling and decreased rate of hydride transfer (16-fold, relative to that of the wild-type enzyme) are not due to differences in ground-state ligand geometries. The V203A substitution may alter the PPV and the reorganization energy for hydrogen transfer, but the protein scaffold and equilibrium thermal motions within the Michaelis complex may be more significant for enzyme catalysis. PMID:24437493

Association of educational status with cardiovascular disease: Teheran Lipid and Glucose Study.

PubMed

Hajsheikholeslami, Farhad; Hatami, Masumeh; Hadaegh, Farzad; Ghanbarian, Arash; Azizi, Fereidoun

2011-06-01

The aim of this study was to evaluate the associations between educational level and cardiovascular disease (CVD) in an older Iranian population. To estimate the odds ratio (OR) of educational level in a cross-sectional study, logistic regression analysis was used on 1,788 men and 2,204 women (222 men and 204 women positive based on their CVD status) aged ≥ 45 years. In men, educational levels of college degree and literacy level below diploma were inversely associated with CVD in the multivariate model [0.52 (0.28-0.94), 0.61 (0.40-0.92), respectively], but diploma level did not show any significant association with CVD, neither in the crude model nor in the multivariate model. In women, increase in educational level was inversely associated with risk of CVD in the crude model, but in the multivariate adjusted model, literacy level below diploma decreased risk of CVD by 39%, compared with illiteracy. Our findings support those of developed countries that, along with other CVD risk factors, educational status has an inverse association with CVD among a representative Iranian population of older men and women.

Crystal Structure of Green Fluorescent Protein Clover and Design of Clover-Based Redox Sensors.

PubMed

Campbell, Benjamin C; Petsko, Gregory A; Liu, Ce Feng

2018-02-06

We have determined the crystal structure of Clover, one of the brightest fluorescent proteins, and found that its T203H/S65G mutations relative to wild-type GFP lock the critical E222 side chain in a fixed configuration that mimics the major conformer of that in EGFP. The resulting equilibrium shift to the predominantly deprotonated chromophore increases the extinction coefficient (EC), opposes photoactivation, and is responsible for the bathochromic shift. Clover's brightness can further be attributed to a π-π stacking interaction between H203 and the chromophore. Consistent with these observations, the Clover G65S mutant reversed the equilibrium shift, dramatically decreased the EC, and made Clover photoactivatable under conditions that activated photoactivatable GFP. Using the Clover structure, we rationally engineered a non-photoactivatable redox sensor, roClover1, and determined its structure as well as that of its parental template, roClover0.1. These high-resolution structures provide deeper insights into structure-function relationships in GFPs and may aid the development of excitation-improved ratiometric biosensors. Copyright © 2017 Elsevier Ltd. All rights reserved.

Mid-infrared spectral characteristics of lipid molecular structures in Brassica carinata seeds: relationship to oil content, fatty acid and glucosinolate profiles, polyphenols, and condensed tannins.

PubMed

Xin, Hangshu; Khan, Nazir A; Falk, Kevin C; Yu, Peiqiang

2014-08-13

The objectives of this study were to quantify lipid-related inherent molecular structures using a Fourier transform infrared spectroscopy (FT-IR) technique and determine their relationship to oil content, fatty acid and glucosinolate profile, total polyphenols, and condensed tannins in seeds from newly developed yellow-seeded and brown-seeded Brassica carinata lines. Canola seeds were used as a reference. The lipid-related molecular spectral band intensities were strongly correlated to the contents of oil, fatty acids, glucosinolates, and polyphenols. The regression equations gave relatively high predictive power for the estimation of oil (R² = 0.99); all measured fatty acids (R² > 0.80), except C14:0, C20:3n-3, C22:2n-9, and C22:2n-6; 3-butenyl, 2-OH-3-butenyl, 4-OH-3-CH3-indolyl, and total glucosinolates (R² > 0.686); and total polyphenols (R² = 0.935). However, further study is required to obtain predictive equations based on large numbers of samples from diverse sources to illustrate the general applicability of these regression equations.

MMP-3 gene polymorphisms are associated with increased risk of osteoarthritis in Chinese men.

PubMed

Guo, Wen; Xu, Pengcheng; Jin, Tianbo; Wang, Jihong; Fan, Dongsheng; Hao, Zengtao; Ji, Yuntao; Jing, Shangfei; Han, Chaoqian; Du, Jieli; Jiang, Dong; Wen, Shuzheng; Wang, Jianzhong

2017-10-03

Osteoarthritis (OA) is the most common late-onset degenerative joint disease., It is characterized by progressive degradation of articular cartilage. We investigated the association between OA occurrence and single nucleotide polymorphisms (SNPs) in the matrix metalloproteinase-3 ( MMP-3 ) gene involved in the breakdown of extra-cellular matrix proteins. The study included 100 male OA patients and 197 healthy men from the north area of China. Eight MMP-3 SNPs were genotyped. Odds ratios (ORs) with 95% confidence intervals (95%CIs) and multivariate logistic regression analysis were used to assess the association. Multivariate logistic regression analysis was used to identify SNPs that correlated with OA susceptibility. We found that rs639752 (dominant, OR = 2.03, 95% CI: 1.03-4.01, P = 0.038; over-dominant, OR = 2.00, 95% CI: 1.03-3.88, P = 0.037); rs520540 (dominant, OR = 2.03, 95% CI: 1.03-4.01, P = 0.038; over-dominant, OR = 2.00, 95% CI: 1.03-3.88, P = 0.037); rs602128 (dominant, OR = 2.03, 95% CI: 1.03-4.01, P = 0.038; over-dominant, OR = 2.01, 95% CI: 1.03-3.89, P = 0.037); and rs679620 (dominant, OR = 2.03, 95% CI: 1.03-4.01, P = 0.038; over-dominant, OR = 2.04, 95% CI: 1.05-3.96, P = 0.033) were associated with the increased risk of OA. Our results suggest that these SNPs may contribute to OA development, and could serve as molecular markers of OA susceptibility.

Ultraviolet spectra of quenched carbonaceous composite derivatives: Comparison to the '217 nanometer' interstellar absorption feature

NASA Technical Reports Server (NTRS)

Sakata, Akira; Wada, Setsuko; Tokunaga, Alan T.; Narisawa, Takatoshi; Nakagawa, Hidehiro; Ono, Hiroshi

1994-01-01

QCCs (quenched carbonaceous composite) are amorphus carbonaceous material formed from a hydrocarbon plasma. We present the UV-visible spectra of 'filmy QCC; (obtained outside of the beam ejected from the hydrocarbon plasma) and 'dark QCC' (obtained very near to the beam) for comparison to the stellar extinction curve. When filmy QCC is heated to 500-700 C (thermally altered), the wavelength of the absorption maximum increases form 204 nm to 220-222 nm. The dark QCC has an absorption maximum at 217-222 nm. In addition, the thermally altered filmy QCC has a slope change at about 500 nm which resmbles that in the interstellar extinction curve. The resemblance of the extinction curve of the QCCs to that of the interstellar medium suggests that QCC derivatives may be representative of the type of interstellar material that produces the 217 nm interstellar medium feature. The peak extinction of the dark QCC is higher than the average interstellar extinction curve while that of the thermally altered filmy QCC is lower, so that a mixture of dark and thermally altered filmy QCC can match the peak extinction observed in the interstellar medium. It is shown from electron micrographs that most of the thermally altered flimy QCC is in the form of small grainy structure less than 4 nm in diameter. This shows that the structure unit causing the 217-222 nm feature in QCC is very small.

Exosomal microRNA profiling to identify hypoxia-related biomarkers in prostate cancer

PubMed Central

Panigrahi, Gati K.; Ramteke, Anand; Birks, Diane; Abouzeid Ali, Hamdy E.; Venkataraman, Sujatha; Agarwal, Chapla; Vibhakar, Rajeev; Miller, Lance D.; Agarwal, Rajesh; Abd Elmageed, Zakaria Y.; Deep, Gagan

2018-01-01

Hypoxia and expression of hypoxia-related biomarkers are associated with disease progression and treatment failure in prostate cancer (PCa). We have reported that exosomes (nanovesicles of 30-150 nm in diameter) secreted by human PCa cells under hypoxia promote invasiveness and stemness in naïve PCa cells. Here, we identified the unique microRNAs (miRNAs) loaded in exosomes secreted by PCa cells under hypoxia. Using TaqMan® array microRNA cards, we analyzed the miRNA profile in exosomes secreted by human PCa LNCaP cells under hypoxic (ExoHypoxic) and normoxic (ExoNormoxic) conditions. We identified 292 miRNAs loaded in both ExoHypoxic and ExoNormoxic. The top 11 miRNAs with significantly higher level in ExoHypoxic compared to ExoNormoxic were miR-517a, miR-204, miR-885, miR-143, miR-335, miR-127, miR-542, miR-433, miR-451, miR-92a and miR-181a; and top nine miRNA with significantly lower expression level in ExoHypoxic compared to ExoNormoxic were miR-521, miR-27a, miR-324, miR-579, miR-502, miR-222, miR-135b, miR-146a and miR-491. Importantly, the two differentially expressed miRNAs miR-885 (increased expression) and miR-521 (decreased expression) showed similar expression pattern in exosomes isolated from the serum of PCa patients compared to healthy individuals. Additionally, miR-204 and miR-222 displayed correlated expression patterns in prostate tumors (Pearson R = 0.66, p < 0.0001) by The Cancer Genome Atlas (TCGA) prostate adenocarcinoma (PRAD) genomic dataset analysis. Overall, the present study identified unique miRNAs with differential expression in exosomes secreted from hypoxic PCa cells and suggests their potential usefulness as a biomarker of hypoxia in PCa patients. PMID:29568403

Circular dichroism and UV resonance Raman study of the impact of alcohols on the Gibbs free energy landscape of an α-helical peptide†

PubMed Central

Xiong, Kan; Asher, Sanford A

2010-01-01

We used CD and UV resonance Raman spectroscopy to study the impact of alcohols on the conformational equilibria and relative Gibbs free energy landscapes along the Ramanchandran Ψ-coordinate of a mainly poly-ala peptide, AP of sequence AAAAA(AAARA)3A. 2,2,2-trifluroethanol (TFE) most stabilizes the α-helical-like conformations, followed by ethanol, methanol and pure water. The π-bulge conformation is stabilized more than the α-helix, while the 310-helix is destabilized due to the alcohol increased hydrophobicity. Turns are also stabilized by alcohols. We also found that while TFE induces more α-helices, it favors multiple, shorter helix segments. PMID:20225890

Contraception and condom use among Bolivian female sex workers: relationship-specific associations between disease prevention and family planning behaviors.

PubMed

Yam, Eileen A; Tinajeros, Freddy; Revollo, Rita; Richmond, Kara; Kerrigan, Deanna L; Garcia, Sandra G

2013-01-01

We examined data from a clinic-based survey of 1,222 Bolivian female sex workers (FSWs) to assess whether use of nonbarrier modern contraception is associated with less consistent condom use with clients and noncommercial partners. Women who were using nonbarrier modern contraception were less likely than nonusers to consistently use condoms with noncommercial partners (AOR 0.393, 95% CI 0.203-0.759, p = .005). With clients, this inverse association did not hold. Public health professionals must consider both disease prevention and pregnancy prevention needs in this vulnerable population, and messages should be tailored to encourage dual method use with all partners.

Large multi-centre pilot randomized controlled trial testing a low-cost, tailored, self-help smoking cessation text message intervention for pregnant smokers (MiQuit).

PubMed

Naughton, Felix; Cooper, Sue; Foster, Katharine; Emery, Joanne; Leonardi-Bee, Jo; Sutton, Stephen; Jones, Matthew; Ussher, Michael; Whitemore, Rachel; Leighton, Matthew; Montgomery, Alan; Parrott, Steve; Coleman, Tim

2017-07-01

To estimate the effectiveness of pregnancy smoking cessation support delivered by short message service (SMS) text message and key parameters needed to plan a definitive trial. Multi-centre, parallel-group, single-blinded, individual randomized controlled trial. Sixteen antenatal clinics in England. Four hundred and seven participants were randomized to the intervention (n = 203) or usual care (n = 204). Eligible women were < 25 weeks gestation, smoked at least one daily cigarette (> 5 pre-pregnancy), were able to receive and understand English SMS texts and were not already using text-based cessation support. All participants received a smoking cessation leaflet; intervention participants also received a 12-week programme of individually tailored, automated, interactive, self-help smoking cessation text messages (MiQuit). Seven smoking outcomes, including validated continuous abstinence from 4 weeks post-randomization until 36 weeks gestation, design parameters for a future trial and cost-per-quitter. Using the validated, continuous abstinence outcome, 5.4% (11 of 203) of MiQuit participants were abstinent versus 2.0% (four of 204) of usual care participants [odds ratio (OR) = 2.7, 95% confidence interval (CI) = 0.93-9.35]. The Bayes factor for this outcome was 2.23. Completeness of follow-up at 36 weeks gestation was similar in both groups; provision of self-report smoking data was 64% (MiQuit) and 65% (usual care) and abstinence validation rates were 56% (MiQuit) and 61% (usual care). The incremental cost-per-quitter was £133.53 (95% CI = -£395.78 to 843.62). There was some evidence, although not conclusive, that a text-messaging programme may increase cessation rates in pregnant smokers when provided alongside routine NHS cessation care. © 2017 The Authors. Addiction published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.

The Pb Isotope Pedigree of Western Samoan Volcanics: New Insights From High-Precision Analysis by NEPTUNE ICP/MS

NASA Astrophysics Data System (ADS)

Hart, S. R.; Workman, R. K.; Coetzee, M.; Blusztajn, J. S.; Ball, L.; Johnson, K. T.

2002-12-01

The Samoan hotspot has produced a chain of volcanism stretching from the island of Savai'i in the west to the presently active "leading-edge" volcano, Vailulu'u, in the east. An alignment of seamounts and submarine banks extending west of Savai'i is believed to be the earliest expression of the hotspot (Johnson, 1986). In 2001, we sampled the oldest shield exposures on Savai'i and western Upolu; these, and samples from the western banks Lalla Rookh, Combe and Alexa, have been analyzed for Pb isotopes using a new high precision Pb technique developed on the NEPTUNE ICP/Multi-Collector at W.H.O.I. Pb samples were doped with the NBS 997 thallium standard, with Pb/Tl ratios between 4 and 10; mass discrimination was adjusted to 205Tl/203Tl=2.387075 using an exponential fractionation law. Each run consisted of 35 cycles (16 s each) at an uptake rate of 0.13 μl/min (~12 minutes per run). The abundance sensitivity of the NEPTUNE is 2 ppm downmass and 1 ppm upmass; tailing at mass 204 from Tl is therefore ~30 ppm for 204Pb in a Pb/Tl = 4 solution. This can be adequately accounted for by careful selection of off-peak baseline positions. Beyond this effect, there is no dependence of Pb isotope ratios on Pb/Tl, over the range from 4-10. The correction on 204Pb for 204Hg was also minimal (20-30 ppm) and quite stable. Thirty runs of the NBS 981 standard (200 ppb solution, 12 different days over a period of 5 months) produced results very similar to the best TIMS data, with excellent external reproducibility: 206Pb/204Pb=19.9309(90), 207Pb/204Pb=15.4843(98), 208Pb/204Pb=36.6756(112) (in parenthesis, +/- 2σ in ppm). Similar external reproducibility was achieved for the Samoan basalt samples (duplicate runs on different days on solution splits from a single chemistry: +/- 2σ ppm = 101, 89 and 117, respectively). Over this time period, the variability of Tl mass bias was very small (+/- 130 ppm standard deviation). The only significant pitfall we have encountered is a memory effect that we believe is related to re-sputtering of prior Pb's (particularly the unradiogenic 981's) from the cones. Our results from the Savai'i and Upolu shields form well-defined linear arrays, separate but parallel in 208/204-206/204 and intersecting in 207/204-206/204; the Savai'i array in the latter plot is unusual in that it has a negative slope. The Upolu shield data is distinct from the Upolu post-erosional field; however, the Savai'i shield is only marginally resolvable from the Savai'i post-erosional field. The Pb data from Lalla Rookh and Combe banks are firmly ensconced in the general field of Samoan Pb's; the data from Alexa Bank, while outside the Samoan field, is aligned with it and arguably "Samoan". This new data extend the evidence of Samoan hotspot activity back in time by at least 600 km, and possibly 1400 km (9-20 m.y. at 7cm/year plate velocity).

Age-related changes of n-3 and n-6 polyunsaturated fatty acids in the anterior cingulate cortex of individuals with major depressive disorder.

PubMed

Conklin, Sarah M; Runyan, Caroline A; Leonard, Sherry; Reddy, Ravinder D; Muldoon, Matthew F; Yao, Jeffrey K

2010-01-01

Accumulating evidence finds a relative deficiency of peripheral membrane fatty acids in persons with affective disorders such as unipolar and bipolar depression. Here we sought to investigate whether postmortem brain fatty acids within the anterior cingulate cortex (BA-24) varied according to the presence of major depression at the time of death. Using capillary gas chromatography we measured fatty acids in a depressed group (n=12), and in a control group without lifetime history of psychiatric diagnosis (n=14). Compared to the control group, the depressed group showed significantly lower concentrations of numerous saturated and polyunsaturated fatty acids including both the n-3 and n-6 fatty acids. Additionally, significant correlations between age at death and precursor (or metabolites) in the n-3 fatty acid pathway were demonstrated in the depressed group but not in control subjects. In the n-6 fatty acid family, the ratio of 20:3(n-6)/18:2(n-6) was higher in patients than in control groups, whereas the ratio of 20:4(n-6)/20:3(n-6) was relatively decreased in patients. Lastly, a significant negative correlation between age and the ratio of 20:4(n-6) to 22:6(n-3) was found in patients, but not in controls. Taken together, decreases in 22:6(n-3) may be caused, at least in part, by the diminished formation of 20:5(n-3), which is derived from 20:4(n-3) through a Delta5 desaturase reaction. The present findings from postmortem brain tissue raise the possibility that an increased ratio of 20:4(n-6) to 22:6(n-3) may provide us with a biomarker for depression. Future research should further investigate these relationships. Published by Elsevier Ltd.

Effect of prophylactic oral calcium supplementation on postpartum mineral status and markers of energy balance of multiparous Jersey cows.

PubMed

Valldecabres, A; Pires, J A A; Silva-Del-Río, N

2018-05-01

The effects of prophylactic oral Ca supplementation on blood mineral status and markers of energy balance were evaluated on 205 multiparous Jersey cows at a commercial dairy. Postpartum, cows were systematically assigned to control (n = 105) or oral Ca supplementation (CaOS; 50 to 60 g of Ca as boluses; n = 100) at 0 and 1 d in milk (DIM). Blood samples for analysis of serum minerals (Ca, P, Mg, K, Na, Fe, Zn, and Cu) were collected before and 1 h after treatment at 0 and 1 DIM, and at 2 DIM. Urine pH was measured immediately before and 1 h after treatment administration (n = 96). A subset of 74 cows was evaluated for plasma glucose and fatty acid concentrations at 0, 1, and 2 DIM. Cows were classified according to their initial calcemic status (Ca status) as normocalcemic (NC; serum Ca >2.12 mmol/L) or subclinically hypocalcemic (SCH; serum Ca ≤2.12 mmol/L). Average serum Ca concentration was higher in CaOS than control cows (2.12 vs. 2.06 mmol/L); this treatment effect was higher for SCH [CaOS (2.03 mmol/L); control (1.89 mmol/L)] than NC cows [CaOS (2.22 mmol/L); control (2.22 mmol/L)]. The incidence of subclinical hypocalcemia was lower for CaOS than control cows (53 vs. 65%); however, at 2 DIM the prevalence of subclinical hypocalcemia tended to be higher for CaOS cows, mostly because it was higher for CaOS-NC than control-NC cows (70 vs. 25%). Urine pH was lower for CaOS than control cows (6.10 vs. 7.04). Lower serum Mg concentration was detected for CaOS-SCH (1.06 mmol/L) than for control-SCH (1.10 mmol/L) cows. Cows in the CaOS group had higher serum K (4.68 vs. 4.53 mmol/L), lower plasma glucose (2.97 vs. 3.10 mmol/L), and at 2 DIM higher plasma fatty acid concentrations (0.43 vs. 0.35 mmol/L) than control cows. Our results showed that postpartum serum Ca concentration increases with oral Ca supplementation, but calcemic status influenced treatment response. Future studies should evaluate the long-term implications on production and reproduction of oral Ca supplementation in Jersey cows. The Authors. Published by FASS Inc. and Elsevier Inc. on behalf of the American Dairy Science Association®. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

Crystal structural characterization reveals novel oligomeric interactions of human voltage-dependent anion channel 1.

PubMed

Hosaka, Toshiaki; Okazaki, Masateru; Kimura-Someya, Tomomi; Ishizuka-Katsura, Yoshiko; Ito, Kaori; Yokoyama, Shigeyuki; Dodo, Kosuke; Sodeoka, Mikiko; Shirouzu, Mikako

2017-09-01

Voltage-dependent anion channel 1 (VDAC1), which is located in the outer mitochondrial membrane, plays important roles in various cellular processes. For example, oligomerization of VDAC1 is involved in the release of cytochrome c to the cytoplasm, leading to apoptosis. However, it is unknown how VDAC1 oligomerization occurs in the membrane. In the present study, we determined high-resolution crystal structures of oligomeric human VDAC1 (hVDAC1) prepared by using an Escherichia coli cell-free protein synthesis system, which avoided the need for denaturation and refolding of the protein. Broad-range screening using a bicelle crystallization method produced crystals in space groups C222 and P22 1 2 1 , which diffracted to a resolution of 3.10 and 3.15 Å, respectively. Each crystal contained two hVDAC1 protomers in the asymmetric unit. Dimer within the asymmetrical unit of the crystal in space group C222 were oriented parallel, whereas those of the crystal in space group P22 1 2 1 were oriented anti-parallel. From a model of the crystal in space group C222, which we constructed by using crystal symmetry operators, a heptameric structure with eight patterns of interaction between protomers, including hydrophobic interactions with β-strands, hydrophilic interactions with loop regions, and protein-lipid interactions, was observed. It is possible that by having multiple patterns of interaction, VDAC1 can form homo- or hetero-oligomers not only with other VDAC1 protomers but also with other proteins such as VDAC2, VDAC3 and apoptosis-regulating proteins in the Bcl-2 family. © 2017 The Protein Society.

Outcomes for Gestational Carriers Versus Traditional Surrogates in the United States.

PubMed

Fuchs, Erika L; Berenson, Abbey B

2018-05-01

Little is known about the obstetric and procedural outcomes of traditional surrogates and gestational carriers. Participants included 222 women living in the United States who completed a brief online survey between November 2015 and February 2016. Differences between gestational carriers (n = 204) and traditional surrogates (n = 18) in demographic characteristics, pregnancy outcomes, and procedural outcomes were examined using chi-squared tests, Fisher's exact tests, and t-tests. Out of 248 eligible respondents, 222 surveys were complete, for a response rate of 89.5%. Overall, obstetric outcomes were similar among gestational carriers and traditional surrogates. Traditional surrogates were more likely than gestational carriers to have a Center for Epidemiologic Studies Depression Scale Revised score of 16 or higher (37.5% vs. 4.0%). Gestational carriers reported higher mean compensation ($27,162.80 vs. $17,070.07) and were more likely to travel over 400 miles (46.0% vs. 0.0%) than traditional surrogates. Procedural differences, but not differences in obstetric outcomes, emerged between gestational carriers and traditional surrogates. To ensure that both traditional surrogates and gestational carriers receive optimal medical care, it may be necessary to extend practice guidelines to ensure that traditional surrogates are offered the same level of care offered to gestational carriers.

Lithium salt doped conjugated polymers as electron transporting materials for highly efficient blue polymer light-emitting diodes

NASA Astrophysics Data System (ADS)

Huang, Fei; Shih, Ping-I.; Liu, Michelle S.; Shu, Ching-Fong; Jen, Alex K.-Y.

2008-12-01

Highly efficient blue polymer light-emitting diodes (PLEDs) are fabricated using a conjugated polymer, poly[9,9-bis(2-(2-(2-diethanol-amino-ethoxy) ethoxy) ethyl) fluorene-alt-4, 4'-phenylether] as an electron transporting layer (ETL). It was found that the performance of these blue-emitting devices could be greatly improved if the ETL was doped with LiF or Li2CO3 salts. A bis[(4,6-di-fluorophenyl)-pyridinato-N, C2] (picolinate) Ir(III) (FIrpic) complex based blue phosphorescent PLED exhibited a maximum luminance efficiency of 20.3 cd/A with a luminance of 1600 cd/m2 at the current density of 7.9 mA/cm2 and drive voltage of 8.0 V.

Emotional abuse of girls in Swaziland: prevalence, perpetrators, risk and protective factors and health outcomes

PubMed Central

Meinck, Franziska; Fry, Deborah; Ginindza, Choice; Wazny, Kerri; Elizalde, Aldo; Spreckelsen, Thees F; Maternowska, M Catherine; Dunne, Michael P

2017-01-01

Background Research on emotional child abuse in sub–Saharan Africa is scarce. Few studies thus far have examined prevalence, risk and protective factors for emotional child abuse or the associations between emotional abuse and girls’ health. Methods A nationally representative two–stage, cluster–sampled, household survey of females aged 13–24 years (n = 1244) on childhood abuse victimisation was conducted. Participants completed interviewer–assisted questionnaires. Associations between emotional abuse and putative risk, and protective factors and health outcomes were analyzed using separate logistic regression models accounting for sampling design. Marginal effects of cumulative risk factors for emotional abuse victimisation were examined. Results Lifetime prevalence of emotional abuse was 28.5% with 58.3% of these girls reporting many abusive incidents. The most common perpetrators were female (27.8%) and male (16.7%) relatives and, more rarely, biological parents. Risk factors associated with emotional abuse were frequent caregiver changes (odds ratio (OR) 1.42, 95% confidence interval (CI) 1.03–1.970, poverty (OR 1.51, 95% CI 1.12–2.03), and physical abuse (OR 1.98, 95% CI 1.45–2.71) and sexual abuse (OR 2.22, 95% CI 1.57–3.10) victimisation. Being close to one’s mother was a protective factor (OR 0.88, 95% CI 0.80–0.97). Risk for emotional abuse increased from 13% with no risk factors present to 58.4% –with all four risk factors present. Health outcomes associated with emotional child abuse were suicidal ideation (OR 1.85, 95% CI 1.30–2.63) and feeling depressed (OR 1.89, 95% CI 1.31–2.71). Conclusions Girls in Swaziland experience high levels of emotional abuse victimisation. Emotional abuse is associated with economic disadvantage, family factors, other types of abuse victimisation and poor mental health. Therefore, a holistic approach to prevention is needed, incorporating poverty reduction and programmes to improve parent–child relationships, reduce the use of harsh criticism, and change parenting social norms. PMID:28607670

Earth Observing System (EOS)/Advanced Microwave Sounding Unit-A (AMSU-A)

NASA Technical Reports Server (NTRS)

Mullooly, William

1995-01-01

This is the thirty-first monthly report for the Earth Observing System (EOS)/Advanced Microwave Sounding Unit- A (AMSU-A), Contract NAS5-32314, and covers the period from 1 July 1995 through 31 July 1995. This period is the nineteenth month of the Implementation Phase which provides for the design, fabrication, assembly, and test of the first EOS/AMSU-A, the Protoflight Model. Included in this report is the Master Program Schedule (Section 2), a report from the Product Team Leaders on the status of all major program elements (Section 3), Drawing status (Section 4), Weight and Power Budgets (CDRL) 503 (Section 5), Performance Assurance (CDRL 204) (Section 6), Configuration Management Status Report (CDRL 203) (Section 7), Documentation/Data Management Status Report (Section 8), and Contract Status (Section 9).

Highly efficient green phosphorescent organic light emitting diodes with improved efficiency roll-off

NASA Astrophysics Data System (ADS)

Thangaraju, K.; Lee, Jonghee; Lee, Jeong-Ik; Chu, Hye Yong; Kim, Yun-Hi; Kwon, Soon-Ki

2015-06-01

A 10-nm thick 4,4',4″-tris(carbazole-9-yl)tri-phenylamine (TcTa) interlayer effectively confines triplet excitons within the emissive layer (EML) of phosphorescent organic light emitting diodes (PHOLEDs) based on green-emitting Ir(ppy)3 dopant and improves the charge balance in the EML of the device, resulting the higher device efficiencies of 61.7 cd/A, 19.7 %, and 43.2 lm/W with the maximum luminance of 75,310 cd/m2 and highly improved efficiency roll-off (22.2% at 20 mA/cm2) when compared to those (61.1 cd/A, 19.6 %, and 47.2 lm/W with a maximum luminance of 38,350 cd/m2) of the standard device with efficiency roll-off of 62.3 % at 20 mA/cm2.

Isotope-ratio measurements of lead in NIST standard reference materials by multiple-collector inductively coupled plasma mass spectrometry.

PubMed

Platzner, I; Ehrlich, S; Halicz, L

2001-07-01

The capability of a second-generation Nu Instruments multiple collector inductively coupled plasma mass spectrometer (MC-ICP-MS) has been evaluated for precise and accurate isotope-ratio determinations of lead. Essentially the mass spectrometer is a double-focusing instrument of Nier-Johnson analyzer geometry equipped with a newly designed variable-dispersion ion optical device, enabling the measured ion beams to be focused into a fixed array of Faraday collectors and an ion-counting assembly. NIST SRM Pb 981, 982, and 983 isotopic standards were used. Addition of thallium to the lead standards and subsequent simultaneous measurement of the thallium and lead isotopes enabled correction for mass discrimination, by use of the exponential correction law and 205Tl/203Tl = 2.3875. Six measurements of SRM Pb-982 furnished the results 206Pb/204Pb = 36.7326(68), 207Pb/204Pb = 17.1543(30), 208Pb/204Pb = 36.7249(69), 207Pb/206Pb = 0.46700(1), and 208Pb/206Pb = 0.99979(2); the NIST-certified values were 36.738(37), 17.159(25), 36.744(50), 0.46707(20), and 1.00016(36), respectively. Direct isotope lead analysis in silicates can be performed without any chemical separation. NIST SRM 610 glass was dissolved and introduced into the MC-ICP-MS by means of a micro concentric nebulizer. The ratios observed were in excellent agreement with previously reported data obtained by TIMS and laser ablation MC-ICP-MS, despite the high Ca/Pb concentration ratio (200/1) and the presence of many other elements at levels comparable with that of lead. Approximately 0.2 microg lead are sufficient for isotope analysis with ratio uncertainties between 240 and 530 ppm.

De novo arachidonic acid synthesis in Perkinsus marinus, a protozoan parasite of the eastern oyster Crassostrea virginica.

PubMed

Chu, Fu-Lin E; Lund, Eric; Soudant, Philippe; Harvey, Ellen

2002-02-01

The capability of synthesizing fatty acids de novo in the meront stage of the oyster protozoan parasite, Perkinsus marinus, was investigated employing stable-isotope-labeled precursors (1,2 13C-acetate and palmitic-d(31) acid). Fatty acid methyl esters derived from 1,2 13C-acetate and palmitic-d(31) acid were analyzed using gas chromatography/mass spectrometry and gas chromatography/flame ionization detection. Results revealed that in vitro cultured P. marinus meronts utilized 13C-acetate to synthesize a range of saturated and unsaturated fatty acids. The saturated fatty acids 14:0, 16:0, 18:0, 20:0, 22:0, 24:0 and the unsaturated fatty acids, 18:1(n-9), 18:2(n-6), 20:1(n-9), 20:2(n-6), 20:2(n-9), 20:3(n-6), 20:4(n-6) were found to contain 13C, after 7, 14, and 21 days incubation with the precursor. This indicates that meronts can synthesize fatty acid de novo using acetate as a substrate. Meronts efficiently elongated 16:0-d(31) to 18:0, 20:0, 22:0, 24:0, but desaturation activity was limited, after 7 and 14 days cultivation. Only a small quantity of 18:1-d(29) was detected. This suggests that meronts cannot directly convert exogenous palmitic acid or its products of elongation to unsaturated counterparts. The ability to synthesize 20:4(n-6) from acetate is particularly interesting. No parasitic protozoan has been reported to be capable of synthesizing long chain essential fatty acids, such as 20:4(n-6) de novo. Future study will be directed to determine whether the observed in vitro activities indeed reflect the in vivo activities, when meronts are associated with the host.

Organizational Justice and the Shortage of Nurses in Medical & Educational Hospitals, in Urmia-2014

PubMed Central

Fathabad, Heidar Sharifi; Yazdanpanah, Abbas; Hessam, Somayeh; Chimeh, Elham Ehsani; Aghlmand, Siamak

2016-01-01

Objective: One of the most important reasons of turnover is perceptions of organizational justice. The purpose of this study was to investigate the effect of perceived organizational justice and its components on turnover intentions of nurses in hospitals of Urmia University of Medical Sciences. Methods: This cross-sectional study was among nurses. 310 samples were estimated according to Morgan Table. Two valid and reliable questionnaires of turnover and organizational justice were used. Data analysis was performed using the software SPSS20. Using the Kolmogorov-Smirnov test, the normality and relationship between variables with Pearson and Spearman correlation test were analyzed. Results: Most people were married and aged between 26 and 35 years, BA and were hired with contraction. The mean score of organizational justice variable was 2.59. The highest average was the interactional justice variable (2.81) and then Procedural fairness variable (2.75) and distributive justices (2.03) were, respectively. The mean range of turnover variable was 3.10. The results showed weak and negative relationship between various dimensions of organizational justice and turnover in nurses. Conclusion: Organizational justice and turnover had inverse relationship with each other. Therefore how much organizational justice in the organization is more; employees tend to stay more. Finally, suggestions for improvement of justice proposed. PMID:26383199

Organizational Justice and the Shortage of Nurses in Medical & Educational Hospitals, in Urmia-2014.

PubMed

Fathabad, Heidar Sharifi; Yazdanpanah, Abbas; Hessam, Somayeh; Chimeh, Elham Ehsani; Aghlmand, Siamak

2015-06-12

One of the most important reasons of turnover is perceptions of organizational justice. The purpose of this study was to investigate the effect of perceived organizational justice and its components on turnover intentions of nurses in hospitals of Urmia University of Medical Sciences. This cross-sectional study was among nurses. 310 samples were estimated according to Morgan Table. Two valid and reliable questionnaires of turnover and organizational justice were used. Data analysis was performed using the software SPSS20. Using the Kolmogorov-Smirnov test, the normality and relationship between variables with Pearson and Spearman correlation test were analyzed. Most people were married and aged between 26 and 35 years, BA and were hired with contraction. The mean score of organizational justice variable was 2.59. The highest average was the interactional justice variable (2.81) and then Procedural fairness variable (2.75) and distributive justices (2.03) were, respectively. The mean range of turnover variable was 3.10. The results showed weak and negative relationship between various dimensions of organizational justice and turnover in nurses. Organizational justice and turnover had inverse relationship with each other. Therefore how much organizational justice in the organization is more; employees tend to stay more. Finally, suggestions for improvement of justice proposed.

[Study on the prevalence of loss to follow-up and risk factors among human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients in Baoshan city, Yunnan province].

PubMed

Huang, Dongsheng; Zheng, Weibin; Yang, Jiafang; Li, Yanping; Hu, Anyan; Xu, Zhengcui

2014-08-01

To determine the prevalence of loss to follow-up (PLF) and risk factors among human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients from 1989 to 2012 in Baoshan city, Yunnan province. The epidemic and follow-up databases of HIV/AIDS patients by the end of 2012 were downloaded from "the history card downloading site" of HIV/AIDS database in China Information System for Disease Control and Prevention and obtained the related data of patients from 1989 to 2012 who had local residence in Baoshan city. These data included demographic characteristics (genders, age at the time of HIV testing positive, and occupation, marital status, and education levels, et al), transmission routes, and disease staging, antiretroviral therapy (ART), and sources of samples, the first CD4(+)T cell counts, and status of follow-up, et al. Descriptive epidemiological study was used to describe the general characteristics of loss to follow-up. Multivariable Cox regression was used for determining risk factors associated with loss to follow-up. A total of 3 295 eligible HIV/AIDS patients from 1989 to 2012 were included. The accumulative study person-year was 11 416.59 years, 222 HIV/AIDS patients were lost to follow-up, and the PLF was 0.019 4/ person years (py). The highest PLF was 0.052 8/py in 2008, the lowest was 0.006 2/py in 2012. The lost patients included 56.76% (126/222) males and 43.24% (96/222) females, the PLFs were 0.020 4/py, 0.018 3/py, respectively. Baoshan city, other cities in Yunnan province, and other provinces, foreign nationality as the family register reached 53.60% (119/222) , 28.83% (64/222) , and 5.86% (13/222) , 11.71% (26/222) , respectively, and their PLFs were 0.012 5/py, 0.046 3/py, and 0.053 6/py, 0.095 6/py, respectively. Receiving ART and not receiving ART occupied 6.76% (15/222) , 93.24% (207/222) , respectively, and the PLFs were 0.001 9/py, 0.0588/py. AIDS and HIV staging standed at 8.11% (18/222) , 91.89% (204/222) , respectively, and the PLFs were 0.003 3, 0.034 5/py. The first CD4(+)T cell counts < 200, 200-350, and > 350 cells /ml accounted for 4.95% (11/222) , 73.87% (164/222) , 21.17% (47/222) , respectively, and the PLFs were 0.004 8/py, 0.024 0/py, 0.020 3/py. The results of multivariable Cox regression showed the risks of loss to follow-up (RLFs) of family register as other cities in Yunnan province (HR = 3.11, 95%CI:2.28-4.25) , other provinces (HR = 2.55, 95%CI:1.42-4.56) , and foreign nationality (HR = 2.12, 95%CI:1.35-3.33) higher than that of Baoshan city, respectively. The RLFs of not receiving ART (HR = 20.83, 95%CI:11.74-36.96) and HIV staging (HR = 3.61, 95%CI:1.82-7.16) were higher than those of receiving ART and AIDS staging, respectively, moreover, the RFLs of the first CD4(+)T cell counts between 200-350 cells/ml (HR = 0.35, 95%CI:0.15-0.82) and the first CD4(+)T cell counts > 350 cells/ml (HR = 0.29, 95%CI:0.12-0.72) were less than that of first CD4(+)T cell counts < 200 cells /ml, respectively. The RLF of transmission route as injecting drug (HR = 0.60, 95%CI:0.41-0.88) was less than that of heterosexual contact. Overall, the prevalence of loss to follow-up among HIV/AIDS patients shows a downward trend, moreover, patients of outsiders, heterosexual contact, HIV staging, baseline CD4(+)T cell counts < 200 cells/ml are at higher risk of loss to follow-up.

U.S. Navy Hindcast Spectral Ocean Wave Model Climatic Atlas: North Atlantic Ocean

DTIC Science & Technology

1983-10-01

203 204 205 206 207 208 LES 209 212 215 218 221 224 227 230 233 236 239 242 245 248 251 254 257 260 263 266 269 272 275 278 281 284 287 290 293 296...34 10 - 34 22 1 f I I I - 20 LL .1 2 1 2 3 13 1 2 2 S 3 L 112 1 -12 2 - - 2 2 3 1 291 2 1 2 1 1 2 2 2 so 1 281 22 - - - L _ 22 2213 1 -Is I a...70 311 70 3428 so 281 20 1 .80 2 1 - 2 28 so - - - 20 1 1 281 -402 . . .. 3 is22 22 30 22 so goso *0 22 22 3 22Isso Is to 3 1 - I - - - - 17 -. L I I

Homofermentative production of optically pure L-lactic acid from xylose by genetically engineered Escherichia coli B.

PubMed

Zhao, Jinfang; Xu, Liyuan; Wang, Yongze; Zhao, Xiao; Wang, Jinhua; Garza, Erin; Manow, Ryan; Zhou, Shengde

2013-06-07

Polylactic acid (PLA), a biodegradable polymer, has the potential to replace (at least partially) traditional petroleum-based plastics, minimizing "white pollution". However, cost-effective production of optically pure L-lactic acid is needed to achieve the full potential of PLA. Currently, starch-based glucose is used for L-lactic acid fermentation by lactic acid bacteria. Due to its competition with food resources, an alternative non-food substrate such as cellulosic biomass is needed for L-lactic acid fermentation. Nevertheless, the substrate (sugar stream) derived from cellulosic biomass contains significant amounts of xylose, which is unfermentable by most lactic acid bacteria. However, the microorganisms that do ferment xylose usually carry out heterolactic acid fermentation. As a result, an alternative strain should be developed for homofermentative production of optically pure L-lactic acid using cellulosic biomass. In this study, an ethanologenic Escherichia coli strain, SZ470 (ΔfrdBC ΔldhA ΔackA ΔpflB ΔpdhR ::pflBp6-acEF-lpd ΔmgsA), was reengineered for homofermentative production of L-lactic acid from xylose (1.2 mole xylose = > 2 mole L-lactic acid), by deleting the alcohol dehydrogenase gene (adhE) and integrating the L-lactate dehydrogenase gene (ldhL) of Pediococcus acidilactici. The resulting strain, WL203, was metabolically evolved further through serial transfers in screw-cap tubes containing xylose, resulting in the strain WL204 with improved anaerobic cell growth. When tested in 70 g L-1 xylose fermentation (complex medium), WL204 produced 62 g L-1 L-lactic acid, with a maximum production rate of 1.631 g L-1 h-1 and a yield of 97% based on xylose metabolized. HPLC analysis using a chiral column showed that an L-lactic acid optical purity of 99.5% was achieved by WL204. These results demonstrated that WL204 has the potential for homofermentative production of L-lactic acid using cellulosic biomass derived substrates, which contain a significant amount of xylose.

Emanation of radon from household granite.

PubMed

Kitto, Michael E; Haines, Douglas K; Arauzo, Hernando Diaz

2009-04-01

Emanation of radon (222Rn) from granite used for countertops and mantels was measured with continuous and integrating radon monitors. Each of the 24 granite samples emitted a measurable amount of radon. Of the two analytical methods that utilized electret-based detectors, one measured the flux of radon from the granite surfaces, and the other one measured radon levels in a glass jar containing granite cores. Additional methods that were applied utilized alpha-scintillation cells and a continuous radon monitor. Measured radon flux from the granites ranged from 2 to 310 mBq m-2 s-1, with most granites emitting <20 mBq m-2 s-1. Emanation of radon from granites encapsulated in airtight containers produced equilibrium concentrations ranging from <0.01 to 11 Bq kg-1 when alpha-scintillation cells were used, and from <0.01 to 4.0 Bq kg-1 when the continuous radon monitor was used.

A rare eicosanoid precursor analogue, sciadonic acid (5Z,11Z,14Z-20:3), detected in vivo in hormone positive breast cancer tissue.

PubMed

Park, H G; Zhang, J Y; Foster, C; Sudilovsky, D; Schwed, D A; Mecenas, J; Devapatla, S; Lawrence, P; Kothapalli, K S D; Brenna, J T

2018-07-01

Numerous genetic alterations of HSA 11q13 are found frequently in several cancer types, including breast cancer (BC). The 11q13 locus harbors FADS2 encoding Δ6 desaturation which is not functional in several cancer cell lines, including hormone positive MCF7 BC cells. In vitro, the non-functional FADS2 activity unmasks 18:2n-6 elongation to 20:2n-6 and Δ5 desaturation by FADS1 to yield 5Z,11Z,14Z-20:3 (sciadonic acid) rather than 5Z,8Z,11Z,14Z-20:4 (arachidonic acid). In this pilot study we aimed to determine whether 5,11,14-20:3 appears in vivo in hormone positive human BC tissue. Fatty acids were profiled in surgically removed human breast tumor and adjacent normal tissue (n = 9). Sciadonic acid was detected in three of nine breast tumor samples and was below detect limits in normal breast tissue. The internal Δ8 double bond of arachidonic acid is required for normal eicosanoid synthesis but is missing in sciadonic acid. This pilot study demonstrates for the first time in vivo sciadonic acid in hormone positive BC tissue, warranting a larger survey study to further evaluate its appearance and the functional implications. Copyright © 2018. Published by Elsevier Ltd.

Is erythropoietin gene a modifier factor in amyotrophic lateral sclerosis?

PubMed

Ghezzi, Serena; Del Bo, Roberto; Scarlato, Marina; Nardini, Martina; Carlesi, Cecilia; Prelle, Alessandro; Corti, Stefania; Mancuso, Michelangelo; Briani, Chiara; Siciliano, Gabriele; Murri, Luigi; Bresolin, Nereo; Comi, Giacomo Pietro

2009-05-01

To investigate the role of erythropoietin (EPO) as genetic determinant in the susceptibility to sporadic amyotrophic lateral sclerosis (SALS). We sequenced a 259-bp region spanning the 3'hypoxia-responsive element of the EPO gene in 222 Italian SALS patients and 204 healthy subjects, matched for age and ethnic origin. No potentially causative variation was detected in SALS subjects; in addition, two polymorphic variants (namely C3434T and G3544T) showed the same genotype and haplotype frequencies in patients and controls. Conversely, a weak but significant association between G3544T and age of disease onset was observed (p=0.04). Overall, our data argue against the hypothesis of EPO as a genetic risk factor for motor neuron dysfunction, at least in Italian population. However, further studies on larger cohort of patients are needed to confirm the evidence of EPO gene as modifier factor.

Determinants of case fatality rates of meningococcal disease during outbreaks in Makkah, Saudi Arabia, 1987-97.

PubMed Central

El Bushra, H. E.; Hassan, N. M.; Al-Hamdan, N. A.; Al-Jeffri, M. H.; Turkistani, A. M.; Al-Jumaily, A.; Ali, M. A.; Rahama, A. M.

2000-01-01

We studied case-fatality rates (CFRs) among cases of meningococcal disease (MCD) admitted to Makkah (Saudi Arabia) hospitals during the period 1988-97. Of 483 cases, 431 (89.2%) were due to strains of serogroup A, 31 (6.4%) to serogroup W135, 16 (3.3%) to serogroup C, and 5 (10%) to serogroup B. Eighty-one patients died (case fatality rate (CFR)) 16.8%, 95% CI 13.5%, 20.4%). The CFR in infections due to serogroup A strains was 14.8%, and for other serogroups it was 32.7% (95% CI 20.3%, 47.1%). The CFR of MCD due to N. meningitidis serogroup A increased steadily with age (P<0.05). Seeking first medical help at a foreign Hajj medical mission and being treated in a non-specialized hospital were associated with a higher case fatality rate. PMID:11218206

AmeriFlux US-Me4 Metolius-old aged ponderosa pine

DOE Data Explorer

Law, Bev [Oregon State University

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site US-Me4 Metolius-old aged ponderosa pine. Site Description - The site is located on land designated as a Research Natural Area (RNA). The site is very open, with even-aged stands of old-growth trees, young trees and mixed aged stands. The eddy-flux tower footprint was classified as ~ 48% mixed aged, ~27% pure old growth and ~25% young aged stands. The data in this workbook describes the mixed aged component. A separate workbook describes the pure old growth component. Law et al (2001) Global Change Biology 7, 755-777; Law et al (2001) Agricultural and Forest Meteorology 110, 27-43; Anthoni et al (2002) Agricultural and Forest Meteorology 111, 203-222; Irvine & Law (2002) Global Change biology 8,1183-1194, Irivne et al (2004) Tree Physiology 24,753-763.

Genomic Characterization and Transcriptional Studies of the Starch-Utilizing Strain Bifidobacterium adolescentis 22L

PubMed Central

Duranti, Sabrina; Turroni, Francesca; Lugli, Gabriele Andrea; Milani, Christian; Viappiani, Alice; Mangifesta, Marta; Gioiosa, Laura; Palanza, Paola; van Sinderen, Douwe

2014-01-01

Bifidobacteria are members of the gut microbiota, but the genetic basis for their adaptation to the human gut is poorly understood. The analysis of the 2,203,222-bp genome of Bifidobacterium adolescentis 22L revealed a nutrient acquisition strategy that targets diet/plant-derived glycans, in particular starch and starch-like carbohydrates. Starch-like carbohydrates were shown to support the growth of B. adolescentis 22L. Transcriptome profiling of 22L cultures grown under in vitro conditions or during colonization of the murine gut by RNA sequencing and quantitative real-time PCR assays revealed the expression of a set of chromosomal loci responsible for starch metabolism as well as for pilus production. Such extracellular structures include so-called sortase-dependent and type IVb pili, which may be involved in gut colonization of 22L through adhesion to extracellular matrix proteins. PMID:25063659

Effect of temperature and pH on polygalacturonase production by pectinolytic bacteria Bacillus licheniformis strain GD2a in submerged medium from Raja Nangka (Musa paradisiaca var. formatypica) banana peel waste

NASA Astrophysics Data System (ADS)

Widowati, E.; Utami, R.; Mahadjoeno, E.; Saputro, G. P.

2017-04-01

The aim of this research were to determine the effect of temperature (45°C, 55°C, 65°C) and pH (5.0; 6.0; 7.0) on the increase of total cell count and polygalacturonase enzyme activity produced from raja nangka banana (Musa paradisiaca var. formatypica) peel waste by pectinolytic bacterial Bacillus licheniformis strain GD2a. This research applied two sample repetition and one analysis repetition. The result showed temperature and pH affect total cell count. The total cell count on 45°C and pH 7 recorded the highest number at 9.469 log cell/ml. Temperature and pH also affected pectin concentration at the end of fermentation. The lowest pectin concentration recorded at 45°C and pH 7 was 0.425 %. The highest enzyme activity recorded at 65°C and pH 7 was 0.204 U/ml. The highest enzyme protein concentration was recorded at 65°C and resulted as 0.310 mg/ml on pH 6. The highest specific activity was 19.527 U/mg at 65°C and pH 7. By this result, could be concluded that optimum condition process on polygalacturonase production was at 65°C and pH 7 because it gave highest enzyme activity result (0,204 U/ml).

Search for extinct natural radioactivity of Pb205 via thallium-isotope anomalies in chondrites and lunar soil.

NASA Technical Reports Server (NTRS)

Huey, J. M.; Kohman, T. P.

1972-01-01

Thallium and Pb204 contents were determined by stable-isotope-dilution analysis in 16 chondrites, one achondrite, and Apollo 11 and 12 lunar fines. Meteoritic thallium contents vary over a large range, 0.02 to 100 ppb, corresponding to the fact that thallium is a highly fractionated volatile element. Lunar thallium contents are less than 5 ppb. The Tl205/Tl203 ratio was determined in most of the samples, with precision ranging from 0.03% to several percent depending mainly on the amount of thallium present. No variations from the terrestrial ratio were observed. The chondritic isochron slope for Pb205 (13.8-m.y. half-life) is less than or equal to 0.00009 (99% confidence level), corresponding to an interval of at least 60 m.y. and possibly exceeding 120 m.y. between the termination of s-process nucleosynthesis and the lead-thallium fractionations.

Relationship between platelet phospholipid FA and mean platelet volume in healthy men.

PubMed

Li, Duo; Turner, Alan; Sinclair, Andrew J

2002-09-01

Increased mean platelet volume (MPV) has been suggested as an independent risk factor for acute myocardial infarction and the increased reactivity of large platelets. The aim of this study was to investigate the correlation between platelet phospholipid (PL) PUFA composition and MPV in 139 free-living healthy men ages 20-55 yr (vegans, n = 18; ovolacto vegetarians, n = 43; moderate meat-eaters, n = 60; and high meateaters, n = 18). Each subject completed a semiquantitative Food Frequency Questionnaire and gave a blood sample. Platelet PL FA composition and MPV were determined by standard methods. MPV was significantly greater in the vegans than in the ovolacto vegetarian, moderate, or high meat-eater groups (P < 0.01). Both vegan and ovolacto vegetarian groups had significantly higher platelet PL 18:2n-6 and 22:4n-6, and lower 20:5n-3 and 22:6n-3 compared with the moderate and high meat-eater groups. The vegans demonstrated a significant reduction in 20:4n-6 and 22:5n-3 compared with the ovolacto vegetarian, high meat-eater, and moderate meat-eater groups. Bivariate analysis results showed that MPV was significantly positively correlated with platelet PL 18:2n-6 (P = 0.048) and negatively correlated with 20:3n-6 (P = 0.02), 20:5n-3 (P = 0.005), and 22:5n-3 (P< 0.0001), respectively. In a multiple linear regression analysis, after controlling for potential confounding factors such as dietary group, age, exercise, body mass index, and dietary polyunsaturated and saturated fat, cholesterol, carbohydrate, and fiber intake, the MPV was still strongly negatively correlated with platelet PL 20:3n-6 (P = 0.003) and 22:5n-3 (P = 0.001). The present data suggest that 22:5n-3 and 20:3n-6 may play a role in the structural function of the platelet membrane.

Air and radon pathways screenings methodologies for the next revision of the E-area PA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dyer, J. A.

The strategic plan for the next E-Area Low-Level Waste Facility Performance Assessment includes recommended changes to the screening criteria used to reduce the number of radioisotopes that are to be considered in the air and radon pathways incorporated into the GoldSim® atmospheric release model (ARM). For the air pathway, a revised screening methodology was developed based on refinement of previous E-Area PA screening approaches and consideration of the strategic plan recommendations. The revised methodology has three sequential screening steps for each radioisotope: (1) volatility test using the Periodic Table of the Elements, (2) stability test based on half-life, and (3)more » stability test based on volatility as measured by the Henry’s Law constant for the assumed dominant gaseous species or vapor pressure in the case of tritiated water. Of the 1252 radioisotopes listed in the International Commission on Radiological Protection Publication 107, only the 10 that satisfied all three steps of the revised screening methodology will be included in the ARM. They are: Ar-37, Ar-39, Ar-42, C-14, H-3, Hg-194, Hg-203, Kr-81, Kr-85, and Xe-127. For the radon pathway, a revised screening methodology was developed that also has three sequential steps: (1) identify all decay chains that terminate at Rn-222, (2) screen out parents that decay through U-238 because of its 4.5-billion-year primordial half-life, and (3) eliminate remaining parents whose half-life is shorter than one day. Of the 86 possible decay chains leading to Rn-222, six decay chains consist of 15 unique radioisotopes that will be incorporated into the ARM. The 15 radioisotopes are: U-238, Th-234, Pa-234m, Pu-238, U-234, Th-230, Ra-226, Cf-246, Cm-242, Am-242m, Am-242, Np-238, Np-234, Pa-230, and Rn-222.« less

An environmental scan of quality indicators in critical care.

PubMed

Valiani, Sabira; Rigal, Romain; Stelfox, Henry T; Muscedere, John; Martin, Claudio M; Dodek, Peter; Lamontagne, François; Fowler, Robert; Gheshmy, Afshan; Cook, Deborah J; Forster, Alan J; Hébert, Paul C

2017-06-21

We performed a directed environmental scan to identify and categorize quality indicators unique to critical care that are reported by key stakeholder organizations. We convened a panel of experts ( n = 9) to identify key organizations that are focused on quality improvement or critical care, and reviewed their online publications and website content for quality indicators. We identified quality indicators specific to the care of critically ill adult patients and then categorized them according to the Donabedian and the Institute of Medicine frameworks. We also noted the organizations' rationale for selecting these indicators and their reported evidence base. From 28 targeted organizations, we identified 222 quality indicators, 127 of which were unique. Of the 127 indicators, 63 (32.5%) were safety indicators and 61 (31.4%) were effectiveness indicators. The rationale for selecting quality indicators was supported by consensus for 58 (26.1%) of the 222 indicators and by published research evidence for 45 (20.3%); for 119 indicators (53.6%), the rationale was not reported or the reader was referred to other organizations' reports. Of the 127 unique quality indicators, 27 (21.2%) were accompanied by a formal grading of evidence, whereas for 52 (40.9%), no reference to evidence was provided. There are many quality indicators related to critical care that are available in the public domain. However, owing to a paucity of rationale for selection, supporting evidence and results of implementation, it is not clear which indicators should be adopted for use. Copyright 2017, Joule Inc. or its licensors.

An environmental scan of quality indicators in critical care

PubMed Central

Valiani, Sabira; Rigal, Romain; Stelfox, Henry T.; Muscedere, John; Martin, Claudio M.; Dodek, Peter; Lamontagne, François; Fowler, Robert; Gheshmy, Afshan; Cook, Deborah J.; Forster, Alan J.; Hébert, Paul C.

2017-01-01

Background: We performed a directed environmental scan to identify and categorize quality indicators unique to critical care that are reported by key stakeholder organizations. Methods: We convened a panel of experts (n = 9) to identify key organizations that are focused on quality improvement or critical care, and reviewed their online publications and website content for quality indicators. We identified quality indicators specific to the care of critically ill adult patients and then categorized them according to the Donabedian and the Institute of Medicine frameworks. We also noted the organizations' rationale for selecting these indicators and their reported evidence base. Results: From 28 targeted organizations, we identified 222 quality indicators, 127 of which were unique. Of the 127 indicators, 63 (32.5%) were safety indicators and 61 (31.4%) were effectiveness indicators. The rationale for selecting quality indicators was supported by consensus for 58 (26.1%) of the 222 indicators and by published research evidence for 45 (20.3%); for 119 indicators (53.6%), the rationale was not reported or the reader was referred to other organizations' reports. Of the 127 unique quality indicators, 27 (21.2%) were accompanied by a formal grading of evidence, whereas for 52 (40.9%), no reference to evidence was provided. Interpretation: There are many quality indicators related to critical care that are available in the public domain. However, owing to a paucity of rationale for selection, supporting evidence and results of implementation, it is not clear which indicators should be adopted for use. PMID:28637683

Word Criticality Analysis MOS: Common Task. Skill Levels 1 & 2.

DTIC Science & Technology

1981-09-01

115#1,o-119,1I . + IP pt N 1 (1’- 29, 1 U-149,1 0- 61,1 J-255,2 0.256,6 0-254PS 0-25l1,3 0-252#3 0-251,1 0-249P 1 . ’J-204, 1 U.201l 0-195, I 0-19.%9 0...E P’ATE 62064, 1650 PAGE 4 C: 3 SxIll 0. Ip Q-19,2 0-s. 0-2813,3 0-237,1 0-24),, 0..251p1 0-250,2 0-249of 0-241,10.252,Z 0-232.1 0-220,1 0-291,2 0...203,1 Vo 1 0 𔃻 I I , Ip MnS WORED LIST BY PAGE DATE 82064 1650 PAGE 60 2 5 A CREE ME IIS 0-319,1 71 3 &LUIIE 01. 3, & 5 Afjyflkp 0.18Is U,2 (177#2 I

Young Single Soldiers and Relationships. Appendix with Crosstabulations

DTIC Science & Technology

1994-03-01

Extremely Bad 21.4 20.4 20.0 12.9 Quite Bad 11.5 10.3 9.5 9.5 Slightly Bad 8.0 8.7 6.7 8.3 Not Good or Bad 24.1 21.7 27.0 21.5 Slightly Good 9.3 10.3 10.2...Slightly Bad 8.2 8.9 5.8 8.2 Not Good or Bad 23.3 21.8 28.0 21.1 Slightly Good 9.2 9.7 9.9 11.2 Quite Good 16.6 19.1 16.6 22.2 Extremely Good 8.4 10.3 9.8...14.4 Female Extremely Bad 9.9 21.5 14.6 10.6 Quite Bad 5.7 12.6 12.3 9.3 Slightly Bad 5.5 7.3 11.8 8.9 Not Good or Bad 33.9 20.9 21.4 23.2 Slightly Good

Whey protein ingestion in elderly persons results in greater muscle protein accrual than ingestion of its constituent essential amino acid content.

PubMed

Katsanos, Christos S; Chinkes, David L; Paddon-Jones, Douglas; Zhang, Xiao-jun; Aarsland, Asle; Wolfe, Robert R

2008-10-01

It is recognized that both whey protein (WY) and essential amino acids (EAA) are stimuli for muscle protein anabolism. The aim of the present study was to determine if the effects of WY ingestion on muscle protein accrual in elderly persons are due solely to its constituent EAA content. Fifteen elderly persons were randomly assigned to ingest a bolus of either 15 g of WY, 6.72 g of EAA, or 7.57 g of nonessential amino acids (NEAA). We used the leg arteriovenous model to measure the leg phenylalanine balance, which is an index of muscle protein accrual. Phenylalanine balance (nmol x min(-1) kg lean leg mass(-1)) during the 3.5 hours after the bolus ingestion improved in the WY (-216 +/- 14 vs -105 +/- 19; P < .05) but not in the EAA (-203 +/- 21 vs -172 +/- 38; P > .05) or NEAA groups (-203 +/- 19 vs -204 +/- 21; P > .05). The insulin response (uIU x mL(-1) 210 min(-1)) during the same period was lower in both the NEAA (48 +/- 40) and EAA (213 +/- 127) when compared to the WY (1073 +/- 229; P < .05). In conclusion, WY ingestion improves skeletal muscle protein accrual through mechanisms that are beyond those attributed to its EAA content. This finding may have practical implications for the formulation of nutritional supplements to enhance muscle anabolism in older individuals.

[Intestinal helminthiasis diagnosed in Dakar, Senegal].

PubMed

Ndiaye, D; Ndiaye, M; Gueye, P A L; Badiane, A; Fall, I D; Ndiaye, Y D; Faye, B; Ndiaye, J L; Tine, R; Ndir, O

2013-01-01

The goal of this study was to determine the prevalence of digestive helminthiasis among patients referred to the laboratory of Parasitology and mycology at Le Dantec Hospital in Dakar for examination of stool samples from 2004 to 2009. Of 1 526 direct stool examinations (Ritchie and Baerman techniques) analyzed at the laboratory of Parasitology and Mycology of Le Dantec Hospital from 2004 to 2009, 310 were positive for intestinal helminthiasis, for a prevalence of 20.3%. The main species found were: Ascaris lumbricoides, Trichuris trichiura, Strongyloides stercoralis, Tænia saginata and Tænia solium. Most patients had a single parasite (90.1%, versus 9% with two and 0.9% with three). Men are infected more often than women, accounting respectively for 58% and 42% of the infections, for a sex ratio of 1.38. Children aged 10 to 15 years had the highest prevalence of infection: 34.5%. The results show that digestive helminthiasis is endemic in Dakar, where it is necessary to implement campaigns of deworming, health education and environmental improvement.

Constructing the Suicide Risk Index (SRI): does it work in predicting suicidal behavior in young adults mediated by proximal factors?

PubMed

O'Connor, Maebh; Dooley, Barbara; Fitzgerald, Amanda

2015-01-01

Suicide is a key concern among young adults. The aim of the study was to (1) construct a suicide risk index (SRI) based on demographic, situational, and behavioral factors known to be linked to suicidal behavior and (2) investigate whether the association between the SRI and suicidal behavior was mediated by proximal processes (personal factors, coping strategies, and emotional states). Participants consisted of 7,558 individuals aged 17-25 years (M = 20.35, SD = 1.91). Nearly 22% (n = 1,542) reported self-harm and 7% (n = 499) had attempted suicide. Mediation analysis revealed both a direct effect (ß = .299, 95% CI = [.281, .317], p < .001), and a mediated effect (ß = .204, 95% CI = [.186, .222], p < .001), between the risk index and suicidal behavior. The strongest mediators were levels of self-esteem, depression, and avoidant coping. Interventions to increase self-esteem, reduce depression, and encourage adaptive coping strategies may prevent suicidal behavior in young people.

Ultrafast electronic and vibrational dynamics of stabilized A state mutants of the green fluorescent protein (GFP): Snipping the proton wire

NASA Astrophysics Data System (ADS)

Stoner-Ma, Deborah; Jaye, Andrew A.; Ronayne, Kate L.; Nappa, Jérôme; Tonge, Peter J.; Meech, Stephen R.

2008-06-01

Two blue absorbing and emitting mutants (S65G/T203V/E222Q and S65T at pH 5.5) of the green fluorescent protein (GFP) have been investigated through ultrafast time resolved infra-red (TRIR) and fluorescence spectroscopy. In these mutants, in which the excited state proton transfer reaction observed in wild-type GFP has been blocked, the photophysics are dominated by the neutral A state. It was found that the A∗ excited state lifetime is short, indicating that it is relatively less stabilised in the protein matrix than the anionic form. However, the lifetime of the A state can be increased through modifications to the protein structure. The TRIR spectra show that a large shifts in protein vibrational modes on excitation of the A state occurs in both these GFP mutants. This is ascribed to a change in H-bonding interactions between the protein matrix and the excited state.

A characterization of horizontal visibility graphs and combinatorics on words

NASA Astrophysics Data System (ADS)

Gutin, Gregory; Mansour, Toufik; Severini, Simone

2011-06-01

A Horizontal Visibility Graph (HVG) is defined in association with an ordered set of non-negative reals. HVGs realize a methodology in the analysis of time series, their degree distribution being a good discriminator between randomness and chaos Luque et al. [B. Luque, L. Lacasa, F. Ballesteros, J. Luque, Horizontal visibility graphs: exact results for random time series, Phys. Rev. E 80 (2009), 046103]. We prove that a graph is an HVG if and only if it is outerplanar and has a Hamilton path. Therefore, an HVG is a noncrossing graph, as defined in algebraic combinatorics Flajolet and Noy [P. Flajolet, M. Noy, Analytic combinatorics of noncrossing configurations, Discrete Math., 204 (1999) 203-229]. Our characterization of HVGs implies a linear time recognition algorithm. Treating ordered sets as words, we characterize subfamilies of HVGs highlighting various connections with combinatorial statistics and introducing the notion of a visible pair. With this technique, we determine asymptotically the average number of edges of HVGs.

Obstructive sleep apnea: strategies for minimizing liability and enhancing patient safety.

PubMed

Svider, Peter F; Pashkova, Anna A; Folbe, Adam J; Eloy, Jean Daniel; Setzen, Michael; Baredes, Soly; Eloy, Jean Anderson

2013-12-01

To characterize malpractice litigation regarding obstructive sleep apnea (OSA) and educate physicians on frequently cited factors. Analysis of the Westlaw legal database. Jury verdict and settlement reports were examined for outcome, awards, patient demographic factors, defendant specialty, and alleged causes of malpractice. Out of 54 identified cases, 33 (61.1%) cases were resolved in favor of defendants, 12 (22.2%) via settlement, and 9 (16.7%) through jury award. Median settlement and jury awards did not significantly differ ($750,000 vs $550,000, P > .50). Age and gender did not affect outcome. Otolaryngologists and anesthesiologists were the most frequently named defendants. Forty-seven cases (87.1%) stemmed from OSA patients who underwent procedures with resultant perioperative adverse events. Common alleged factors included death (48.1%), permanent deficits (42.6%), intraoperative complications (35.2%), requiring additional surgery (25.9%), anoxic brain injury (24.1%), inadequate informed consent (24.1%), inappropriate medication administration (22.2%), and inadequate monitoring (20.4%). Litigation related to OSA is frequently associated with perioperative complications more than nonoperative issues such as a failure to diagnose this disorder. Nonetheless, OSA is considerably underdiagnosed, and special attention should be paid to at-risk patients, including close monitoring of their clinical status and the medications they receive. For patients with diagnosed or suspected OSA with planned operative intervention, whether for OSA or an unrelated issue, a comprehensive informed consent process detailing the factors outlined in this analysis is an effective strategy to increase communication and improve the physician-patient relationship, minimize liability, and ultimately improve patient safety.

Prostate Cancer Cells in Different Androgen Receptor Status Employ Different Leucine Transporters.

PubMed

Otsuki, Hideo; Kimura, Toru; Yamaga, Takashi; Kosaka, Takeo; Suehiro, Jun-Ichi; Sakurai, Hiroyuki

2017-02-01

Leucine stimulates cancer cell proliferation through the mTOR pathway, therefore, inhibiting leucine transporters may be a novel therapeutic target for cancer. L-type amino acid transporter (LAT) 1, a Na + -independent amino acid transporter, is highly expressed in many tumor cells. However, leucine transporter(s) in different stages of prostate cancer, particularly in the stages of castration resistance with androgen receptor (AR) expression, is unclear. LNCaP and DU145 and PC-3 cell lines were used as a model of androgen dependent, and metastatic prostate cancer. A new "LN-cr" cell line was established after culturing LNCaP cells for 6 months under androgen-free conditions, which is considered a model of castration resistant prostate cancer (CRPC) with androgen AR expression. The expression of leucine transporters was investigated with quantitative PCR and immunofluorescence. Uptake of 14 C Leucine was examined in the presence or absence of BCH (a pan-LAT inhibitor), JPH203 (an LAT1-specific inhibitor), or Na + . Cell growth was assessed with MTT assay. siRNA studies were performed to evaluate the indispensability of y + LAT2 on leucine uptake and cell viability in LN-cr. Cell viability showed a 90% decrease in the absence of leucine in all four cell lines. LNCaP cells principally expressed LAT3, and their leucine uptake was more than 90% Na + -independent. BCH, but not JPH203, inhibited leucine uptake, and cell proliferation (IC 50BCH :15 mM). DU145 and PC-3 cells predominantly expressed LAT1. Leucine uptake and cell growth were suppressed by BCH or JPH203 in a dose-dependent manner (IC 50BCH : ∼20 mM, IC 50JPH203 : ∼5 µM). In LN-cr cells, Na + -dependent uptake of leucine was 3.8 pmol/mgprotein/min, while, Na + -independent uptake was only 0.52 (P < 0.05). Leucine uptake of LN-cr was largely (∼85%) Na + -dependent. y + LAT2 expression was confirmed in LN-cr. Knockdown of y + LAT2 lead to significant leucine uptake inhibition (40%) and cell growth inhibition (20%). New CRPC cell line with increased expression of y + LAT2 as a leucine transporter was established in vitro. Anti-leucine transporter therapy could be an important option against prostate cancer. Prostate 77:222-233, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Resident training in a teaching hospital: How do attendings teach in the real operative environment?

PubMed

Glarner, Carly E; Law, Katherine E; Zelenski, Amy B; McDonald, Robert J; Greenberg, Jacob A; Foley, Eugene F; Wiegmann, Douglas A; Greenberg, Caprice C

2017-07-01

The study aim was to explore the nature of intraoperative education and its interaction with the environment where surgical education occurs. Video and audio recording captured teaching interactions between colorectal surgeons and general surgery residents during laparoscopic segmental colectomies. Cases and collected data were analyzed for teaching behaviors and workflow disruptions. Flow disruptions (FDs) are considered deviations from natural case progression. Across 10 cases (20.4 operative hours), attendings spent 11.2 hours (54.7%) teaching, using directing (M = 250.1), and confirming (M = 236.1) most. FDs occurred 410 times, accounting for 4.4 hours of case time (21.57%). Teaching occurred with FD events for 2.4 hours (22.2%), whereas 77.8% of teaching happened outside FD occurrence. Teaching methods shifted from active to passive during FD events to compensate for patient safety. Understanding how FDs impact operative learning will inform faculty development in managing interruptions and improve its integration into resident education. Copyright © 2016. Published by Elsevier Inc.

U-Pb isotope systematics and age of uranium mineralization, Midnite mine, Washington.

USGS Publications Warehouse

Ludwig, K. R.; Nash, J.T.; Naeser, C.W.

1981-01-01

Uranium ores at the Midnite mine, near Spokane, Washington, occur in phyllites and calcsilicates of the Proterozoic Togo Formation, near the margins of an anomalously uraniferous, porphyritic quartz monzonite of Late Cretaceous age. The present geometry of the ore zones is tabular, with the thickest zones above depressions in the pluton-country rock contact. Analyses of high-grade ores from the mine define a 207 Pb/ 204 Pb- 235 U/ 204 Pb isochron indicating an age of mineralization of 51.0 + or - 0.5 m.y. This age coincides with a time of regional volcanic activity (Sanpoil Volcanics), shallow intrusive activity, erosion, and faulting. U-Th-Pb isotopic ages of zircons from the porphyritic quartz monzonite in the mine indicate an age of about 75 m.y., hence the present orebodies were formed about 24 m.y. after its intrusion. The 51-m.y. time of mineralization probably represents a period of mobilization and redeposition of uranium by supergene ground waters, perhaps aided by mild heating and ground preparation and preserved by a capping of newly accumulated, impermeable volcanic rocks. It seems most likely that the initial concentration of uranium occurred about 75 m.y. ago, probably from relatively mild hydrothermal fluids in the contact-metamorphic aureole of the U-rich porphyritic quartz monzonite.Pitchblende, coffinitc, pyrite, marcasite, and hisingerite are the most common minerals in the uranium-bearing veinlets, with minor sphalerite and chalcopyrite. Coffinitc with associated marcasite is paragenetically later than pitchblende, though textural and isotopic evidence suggests no large difference in the times of pitchblende and colfinite formation.The U-Pb isotope systematics of total ores and of pitchblende-coffinite and pyrite-marcasite separates show that whereas open system behavior for U and Pb is essentially negligible for large (200-500 g) ore samples, Pb migration has occurred on a scale of 1 to 10 mm (out of pitchblende and coffinite and into pyrite and marcasite). Also, long-term continuous leakage of radioactive daughters of 238 U (probably 222 Rn) has occurred on scales of from approximately 100 mu m approximately 10 cm. The isotopic composition of unsupported radiogenic Pb in pyrite-marcasite seems to depend on the mineralogical microenvironment of the grains, so that the radiogenic Pb in pyrite-marcasite intimately intermixed with pitchblende-coffinite tends to be deficient in 206 Pb, and the radiogenic Pb in pyrite-marcasite in gangue tends to have excess 206 Pb. These systematics probably reflect differences between the average distances of Pb and 222 Rn diffusion since the formation of the ores.

Consanguinity Among Parents of Iranian Deaf Children.

PubMed

Ajallouyan, Mohammad; Radfar, Shokofeh; Nouhi, Sima; Tavallaie, Seid Abbas; Amirsalari, Susan; Yousefi, Jaleh; Hasanali Fard, Mahdieh

2016-11-01

It seems that there is a relationship between consanguinity and profound hearing loss but there is little data about the association of consanguinity and hearing loss in Iran. The aim of this study is to demonstrate the causes of profound bilateral sensorineural hearing loss among Iranian samples who are candidates for cochlear implantation. This study was retrospective, analytical, and designed to collect information about profound hearing impaired cases referred to the Baqiyatallah Cochlear implantation center using enumeration. A total of 310 children with profound hearing impairments participated in this study. They were aged from 6 months to 4 years old. The study was done between January 2007 and April 2009. Chi-square tests were used to show whether there was any statistical difference between the incidence of marital consanguinity of their parents and the normal population. Sixty-five percent of those 310 children had parents who had married with their relatives. Of the 203 (65%) parents that had consanguineous marriages, 132 were first cousins, which includes the children of two brothers (37 [11.8%] patrilateral parallel cousins), the children of two sisters (38 [12.2%] multi-lateral parallel cousins), or the children of a brother and a sister (57 [18.3%] cross cousins). Fifty-four (17.4%) of the parents were second cousins and 17 (5.2%) were beyond second cousins. Also, hearing loss etiology was obvious in 237 (76.3%) of the patients with profound hearing loss but was unknown in 73 (23.7%). Hereditary was identified as the most common cause in 33% of the cases. Our data demonstrated a 65% occurrence of consanguineous marriage among the parents of deaf children, which is statistically different from the percentage of consanguineous marriage among Iranian population (38%). This indicates an obvious relationship between severe hearing loss and consanguineous marriage.

Exploring the interaction among EPHX1, GSTP1, SERPINE2, and TGFB1 contributing to the quantitative traits of chronic obstructive pulmonary disease in Chinese Han population.

PubMed

An, Li; Lin, Yingxiang; Yang, Ting; Hua, Lin

2016-05-18

Currently, the majority of genetic association studies on chronic obstructive pulmonary disease (COPD) risk focused on identifying the individual effects of single nucleotide polymorphisms (SNPs) as well as their interaction effects on the disease. However, conventional genetic studies often use binary disease status as the primary phenotype, but for COPD, many quantitative traits have the potential correlation with the disease status and closely reflect pathological changes. Here, we genotyped 44 SNPs from four genes (EPHX1, GSTP1, SERPINE2, and TGFB1) in 310 patients and 203 controls which belonged to the Chinese Han population to test the two-way and three-way genetic interactions with COPD-related quantitative traits using recently developed generalized multifactor dimensionality reduction (GMDR) and quantitative multifactor dimensionality reduction (QMDR) algorithms. Based on the 310 patients and the whole samples of 513 subjects, the best gene-gene interactions models were detected for four lung-function-related quantitative traits. For the forced expiratory volume in 1 s (FEV1), the best interaction was seen from EPHX1, SERPINE2, and GSTP1. For FEV1%pre, the forced vital capacity (FVC), and FEV1/FVC, the best interactions were seen from SERPINE2 and TGFB1. The results of this study provide further evidence for the genotype combinations at risk of developing COPD in Chinese Han population and improve the understanding on the genetic etiology of COPD and COPD-related quantitative traits.

Fluorcanasite, K3Na3Ca5Si12O30(F,OH)4 · H2O, a new mineral species from the Khibiny alkaline pluton, Kola Peninsula, Russia, and new data on canasite

NASA Astrophysics Data System (ADS)

Khomyakov, A. P.; Nechelyustov, G. N.; Krivokoneva, G. K.; Rastsvetaeva, R. K.; Rozenberg, K. A.; Rozhdestvenskaya, I. V.

2009-12-01

Fluorcanasite is described, a new mineral species found in dumps of the Kirovsk apatite mine, Mt. Kukisvumchorr, Khibiny alkaline pluton, Kola Peninsula, Russia. The new mineral is associated with microcline, nepheline, aegirine, scherbakovite, lamprophyllite, pectolite, mosandrite, villiaumite, rasvumite, and molybdenite. It occurs as prismatic crystals up to 0.2-0.3 × 1-2 mm in size extending along [010]. Fluorcanasite is purple, transparent, with white streak and vitreous luster. The fracture is hackly along the extension and stepped in other directions. The mineral is brittle. The cleavage is eminent parallel to {100} and {201} and perfect parallel to {001}. D(meas) = 2.68(2) g/cm3 (volumetric method); D(calc) = 2.69 g/cm3. Fluorcanasite is biaxial, negative, n α = 1.538(1), n β = 1.546(1), n γ = 1.549(1), 2 V(meas) = 60(2)°, 2 V(calc) = 63°. Dispersion r > v. The new mineral is pleochroic according to the scheme N β > N γ > N α; N β is purple, N γ is lilac, and N α is amber-yellow. Orientation is as follows: b = N β, a∧ N γ = 3°, c∧ N α = 19°. Fluorcanasite is not luminescent in UV light and slowly decomposes in acid. The new mineral is monoclinic, space group Cm, a = 18.846(4), b = 7.242(1), c = 12.650(2) Å, β = 111.84(2)°, V = 1602.6(4) Å3, Z = 2. The strongest reflections [ d, Å( I)] in the X-ray powder pattern of a grainoriented sample are 2.915(100), 4.204(40), 5.872(36), 4.712(36), 2.358(32), 3.012(24), 2.310(24), 3.082(24) and the same reflections in a randomly oriented sample are 3.082(100), 2.915(85), 4.712(46), 4.204(41), 3.340(35), 5.872(33), 2.658(30). The chemical composition, determined with an electron microprobe, is as follows, wt %: 7.19 Na2O, 10.91 K2O, 19.55 CaO, 0.27 FeO, 2.08 MnO, 55.84 SiO2, 4.10 F, 2.22 H2O (determined on the basis of structural data), 1.73-O = F2; the total is 100.43. The empirical formula, calculated on the basis of Si = 12, is K2.99Na3.00(Ca4.50Mn0.38·Fe{0.05/2+})Σ4.93Si12O29.93(F2.79OH1.21)Σ4 · 0.98H2O. The idealized formula is K3Na3Ca5Si12O30(F,OH)4 · H2O, F > OH or K3Na3Ca5(Si12O30)F4 · H2O. The IR spectrum of the mineral, description of its crystal structure, and comparison with its close analogues, canasite and frankamenite, are given in the paper. New optical parameters and crystal data are presented for the type specimen of canasite from the Materialnaya adit, Mt. Yukspor, Khibiny. Type material is deposited at the Fersman Mineralogical Museum, Russian Academy of Sciences, Moscow.

Use of radiolabeled substrates to determine the desaturase and elongase activities involved in eicosapentaenoic acid and docosahexaenoic acid biosynthesis in the marine microalga Pavlova lutheri.

PubMed

Guihéneuf, Freddy; Ulmann, Lionel; Mimouni, Virginie; Tremblin, Gérard

2013-06-01

The marine flagellate Pavlova lutheri is a microalga known to be rich in long-chain polyunsaturated fatty acids (LC-PUFAs) and able to produce large amounts of n-3 fatty acids, such as eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3). As no previous study had attempted to measure the metabolic step of fatty acid synthesis in this alga, we used radiolabeled precursors to explore the various desaturation and elongation steps involved in LC-PUFA biosynthesis pathways. The incorporation of (14)C-labeled palmitic ([1-(14)C] 16:0) and dihomo-γ-linolenic ([1-(14)C] 20:3n-6) acids as ammonium salts within the cells was monitored during incubation periods lasting 3, 10 or 24h. Total lipids and each of the fatty acids were also monitored during these incubation periods. A decrease in the availability and/or accessibility of the radiolabeled substrates was observed over the incubation time. This decrease with incubation time observed using [1-(14)C] 16:0 and [1-(14)C] 20:3n-6 as substrates was used to monitor the conversion of (14)C-labeled arachidonic acid ([1-(14)C] 20:4n-6) into longer and more unsaturated fatty acids, such as 20:5n-3 and 22:6n-3, over shorter incubation times (1 and 3h). A metabolic relationship between the n-6 and n-3 fatty acid series was demonstrated in P. lutheri by measuring the Δ17-desaturation activity involved in the conversion of eicosatetraenoic acid to 20:5n-3. Our findings suggest that the biosynthesis pathway leading to n-3 LC-PUFA involves fatty acids of the n-6 family, which act as precursors in the biosynthesis of 20:5n-3 and 22:6n-3. This preliminary work provides a method for studying microalgal LC-PUFA biosynthesis pathways and desaturase and elongase activities in vivo using externally-radiolabeled fatty acid precursors as substrates. The use of the [1-(14)C] 20:4n-6 substrate also highlighted the relationships between the n-6 and the n-3 fatty acid series (e.g. Δ17-desaturation), and the final elongation and desaturation steps required for n-3 LC-PUFA formation in P. lutheri. Copyright © 2013 Elsevier Ltd. All rights reserved.

Cooperative spin freezing and the pinning assisted thermoremanent magnetization in Ni{sub 2.04}Mn{sub 1.36}Sn{sub 0.6} alloy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pramanick, S.; Chattopadhyay, S.; Giri, S.

2014-08-28

Detailed investigation on the ground-state magnetic properties of Ni{sub 2.04}Mn{sub 1.36}Sn{sub 0.6} alloy is reported. The sample undergoes martensitic type structural transformation from a cubic austenite phase to an orthorhombic martensite phase on cooling around T{sub M} = 220 K. It orders ferromagnetically just above room temperature with T{sub C} = 310 K. The phases above and below T{sub M} are predominantly ferromagnetic, although incipient antiferromagnetic correlations have been mooted between the Mn atoms sitting at two different crystallographic sites. The zero-field-cooled magnetic state shows a step like anomaly around T{sub B} = 100 K, and the sample is found to show clear signature of spin glass like behaviourmore » below this point. It is also associated with considerable exchange bias effect below T{sub B}, where horizontal shift of isothermal magnetization loop is observed in the field-cooled state. Apart from exchange bias, there exists large thermoremanent magnetization. Interestingly, the thermoremanent magnetization obtained by cooling the sample from above and just below the first order martensitic transition failed to show any sizable change, which rules out any major role of field induced arrest across the first order transition. The observed thermoremanent magnetization is presumably due to the effect of pinning of uncompensated spins in this magnetically inhomogeneous system with random ferromagnetic as well as antiferromagnetic bonds on field cooling through the onset point (T{sub B}) of the spin-glass like state.« less

Major Histocompatibility Complex, demographic, and environmental predictors of antibody presence in a free-ranging mammal.

PubMed

Ruiz-López, María José; Monello, Ryan J; Schuttler, Stephanie G; Lance, Stacey L; Gompper, Matthew E; Eggert, Lori S

2014-12-01

Major Histocompatibility Complex (MHC) variability plays a key role in pathogen resistance, but its relative importance compared to environmental and demographic factors that also influence resistance is unknown. We analyzed the MHC II DRB exon 2 for 165 raccoons (Procyon lotor) in Missouri (USA). For each animal we also determined the presence of immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies to two highly virulent pathogens, canine distemper virus (CDV) and parvovirus. We investigated the role of MHC polymorphism and other demographic and environmental factors previously associated with predicting seroconversion. In addition, using an experimental approach, we studied the relative importance of resource availability and contact rates. We found important associations between IgG antibody presence and several MHC alleles and supertypes but not between IgM antibody presence and MHC. No effect of individual MHC diversity was found. For CDV, supertype S8, one allele within S8 (Prlo-DRB(∗)222), and a second allele (Prlo-DRB(∗)204) were positively associated with being IgG+, while supertype S4 and one allele within the supertype (Prlo-DRB(∗)210) were negatively associated with being IgG+. Age, year, and increased food availability were also positively associated with being IgG+, but allele Prlo-DRB(∗)222 was a stronger predictor. For parvovirus, only one MHC allele was negatively associated with being IgG+ and age and site were stronger predictors of seroconversion. Our results show that negative-frequency dependent selection is likely acting on the raccoon MHC and that while the role of MHC in relation to other factors depends on the pathogen of interest, it may be one of the most important factors predicting successful immune response. Copyright © 2014 Elsevier B.V. All rights reserved.

The Real Practice of Antibiotic Prophylaxis for Prostate Biopsy in Korea Where the Prevalence of Quinolone-Resistant Escherichia coli Is High

PubMed Central

Kim, Dae Hyun; Bae, Sang Rak; Choi, Woo Suk; Paick, Sung Hyun; Kim, Hyeong Gon; Loh, Yong Soo

2014-01-01

Purpose Transrectal ultrasonography-guided prostate biopsy (TRUS-Bx) is an essential procedure for diagnosing prostate cancer. The American Urological Association (AUA) Guideline recommends fluoroquinolone alone for 1 day during TRUS-Bx. However, this recommendation may not be appropriate in regions where the prevalence of quinolone-resistant Escherichia coli is high. We investigated the real practice of antibiotic prophylaxis for TRUS-Bx in Korea. Materials and Methods A total of 77 hospitals performing TRUS-Bx were identified and an e-mail was sent to the Urology Department of those hospitals. The questions in the e-mail included the choice of antibiotics before and after the procedure and the duration of antibiotic therapy after TRUS-Bx. Results A total of 54 hospitals (70.0%) responded to the e-mail. Before TRUS-Bx, all hospitals administered intravenous antibiotic prophylaxis. The percentage of hospitals that used quinolone, cephalosporin, and aminoglycoside alone was 48.1%, 20.4%, and 9.3%, respectively. The percentage of hospitals that used two or more antibiotics was 22.2%. After biopsy, all 54 hospitals prescribed oral antibiotics. The percentage of hospitals that prescribed quinolone alone, cephalosporin alone, or a combination of two or more antibiotics was 77.8%, 20.4%, and 1.8%, respectively. The duration of antibiotic use was more than 3 days in most hospitals (79.6%). Only four hospitals (7.4%) followed the AUA recommendation of a 1-day regimen. Conclusions The AUA recommendation was not followed by most hospitals in Korea. This clinical behavior might reflect the high quinolone resistance rate in Korea, and further studies on the most efficient prophylactic antibiotics after TRUS-Bx in Korea are warranted. PMID:25237461

The real practice of antibiotic prophylaxis for prostate biopsy in Korea where the prevalence of quinolone-resistant Escherichia coli is high.

PubMed

Kim, Dae Hyun; Bae, Sang Rak; Choi, Woo Suk; Park, Hyoung Keun; Paick, Sung Hyun; Kim, Hyeong Gon; Loh, Yong Soo

2014-09-01

Transrectal ultrasonography-guided prostate biopsy (TRUS-Bx) is an essential procedure for diagnosing prostate cancer. The American Urological Association (AUA) Guideline recommends fluoroquinolone alone for 1 day during TRUS-Bx. However, this recommendation may not be appropriate in regions where the prevalence of quinolone-resistant Escherichia coli is high. We investigated the real practice of antibiotic prophylaxis for TRUS-Bx in Korea. A total of 77 hospitals performing TRUS-Bx were identified and an e-mail was sent to the Urology Department of those hospitals. The questions in the e-mail included the choice of antibiotics before and after the procedure and the duration of antibiotic therapy after TRUS-Bx. A total of 54 hospitals (70.0%) responded to the e-mail. Before TRUS-Bx, all hospitals administered intravenous antibiotic prophylaxis. The percentage of hospitals that used quinolone, cephalosporin, and aminoglycoside alone was 48.1%, 20.4%, and 9.3%, respectively. The percentage of hospitals that used two or more antibiotics was 22.2%. After biopsy, all 54 hospitals prescribed oral antibiotics. The percentage of hospitals that prescribed quinolone alone, cephalosporin alone, or a combination of two or more antibiotics was 77.8%, 20.4%, and 1.8%, respectively. The duration of antibiotic use was more than 3 days in most hospitals (79.6%). Only four hospitals (7.4%) followed the AUA recommendation of a 1-day regimen. The AUA recommendation was not followed by most hospitals in Korea. This clinical behavior might reflect the high quinolone resistance rate in Korea, and further studies on the most efficient prophylactic antibiotics after TRUS-Bx in Korea are warranted.

Purification and biochemical characterization of a highly thermostable bacteriocin isolated from Brevibacillus brevis strain GM100.

PubMed

Ghadbane, Mouloud; Harzallah, Daoud; Laribi, Atef Ibn; Jaouadi, Bassem; Belhadj, Hani

2013-01-01

A bacteriocin-producing (11,000 AU mL(-1)) strain was isolated from the rhizosphere of healthy Algerian plants Ononis angustissima Lam., and identified as Brevibacillus brevis strain GM100. The bacteriocin, called Bac-GM100, was purified to homogeneity from the culture supernatant, and, based on MALDI-TOF/MS analysis, was a monomer protein with a molecular mass of 4375.66 Da. The 21 N-terminal residues of Bac-GM100 displayed 65% homology with thurincin H from Bacillus thuringiensis. Bac-GM100 was extremely heat-stable (20 min at 120 °C), and was stable within a pH range of 3-10. It proved sensitive to various proteases, which demonstrated its protein nature. It was also found to display a bactericidal mode of action against gram-negative (Salmonella enteric ATCC 43972, Pseudomonas aeruginosa ATCC 49189, and Agrobacterium tumefaciens C58) and gram-positive (Enterococcus faecalis ENSAIA 631 and Staphylococcus aureus ATCC 6538) bacteria, and a fungistatic mode of action against the pathogenic fungus Candida tropicalis R2 CIP 203.

Profiling of esterified fatty acids as biomarkers in the blood of dengue fever patients using a microliter-scale extraction followed by gas chromatography and mass spectrometry.

PubMed

Khedr, Alaa; Hegazy, Maha; Kamal, Ahmed; Shehata, Mostafa A

2015-01-01

An improved gas chromatography with mass spectrometry procedure was developed to highlight the esterified fatty acids in 100 μL blood of dengue fever patients in the early febrile phase versus healthy volunteers. 24 adult patients and 24 healthy volunteers were included in this study. The recoveries of targeted esterified fatty acids content were in the range of 92.10-101.00% using methanol/dichloromethane (2:1, v/v) as the extraction solvent. An efficient chromatographic separation of targeted 17 esterified fatty acid methyl esters was obtained. The limits of detection and quantification were within the range of 16-131 and 53-430 ng/mL, respectively. The relative standard deviation of intraday and interday precision values ranged from 0.4 to 5.0%. The statistical data treatment showed a significant decrease of the content of four saturated fatty acids, C14:0, C15:0, C16:0, and C18:0 (P value < 0.05), and also showed a decrease of the content of eight unsaturated fatty acids, C16:1, C18:3n6, C18:2n6, C18:1n9, C20:3n3, C20:4n6, C20:2, and C22:6n3 (P value < 0.05) in dengue fever patients. Moreover, the amount of three omega-6 fatty acids including C18:3n6, C18:2n6, and C20:4n6 was dramatically decreased in the blood of dengue fever patients to a limit of 50 ± 10%. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Randomised controlled trials define shape of dose-response for Pollinex Quattro Birch allergoid immunotherapy.

PubMed

Worm, Margitta; Higenbottam, Tim; Pfaar, Oliver; Mösges, Ralph; Aberer, Werner; Gunawardena, Kulasiri; Wessiepe, Dorothea; Lee, Denise; Kramer, Matthias F; Skinner, Murray; Lees, Bev; Zielen, Stefan

2018-05-19

The Birch Allergoid, Tyrosine Adsorbate, Monophosphoryl Lipid A (POLLINEX ® Quattro Plus 1.0 ml Birch 100%) is an effective, well-tolerated short course subcutaneous immunotherapy. We performed two phase II studies to determine its optimal cumulative dose. The studies were conducted in Germany, Austria and Poland (EudraCT numbers: 2012-004336-28 PQBirch203 and 2015-000984-15 PQBirch204) using a wide range of cumulative doses. In both studies, subjects were administered 6 therapy injections weekly outside the pollen season. Conjunctival Provocation Tests were performed at screening, baseline and 3-4 weeks after completing treatment, to quantify the reduction of Total Symptom Scores (as the primary endpoint) with each cumulative dose. Multiple Comparison Procedure and Modelling analysis was used to test for the dose-response, shape of the curve, and estimation of the median effective dose (ED 50 ), a measure of potency. Statistically significant dose-responses (p<0.01 & 0.001) were seen respectively. The highest cumulative dose in PQBirch204 (27300 standardised units [SU]) approached a plateau. Potency of the PQ Birch was demonstrated by an ED 50 2723 SU, just over half the current dose. Prevalence of treatment-emergent adverse events was similar for active doses, most being short-lived and mild. Compliance was over 85% in all groups. Increasing the cumulative dose of PQ Birch 5.5-fold from 5100 to 27300 SU achieved an absolute point difference from placebo of 1.91, a relative difference 32.3% and an increase of efficacy of 50%, without compromising safety. The cumulative dose-response was confirmed to be curvilinear in shape. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Serum Phospholipid Fatty Acid Composition in Cystic Fibrosis Patients with and without Liver Cirrhosis.

PubMed

Drzymała-Czyż, Sławomira; Szczepanik, Mariusz; Krzyżanowska, Patrycja; Duś-Żuchowska, Monika; Pogorzelski, Andrzej; Sapiejka, Ewa; Juszczak, Paweł; Lisowska, Aleksandra; Koletzko, Berthold; Walkowiak, Jarosław

2017-01-01

Cystic fibrosis (CF) liver disease is the third most frequent cause of death in CF patients. Although it alters fatty acid (FA) metabolism, data concerning the profile of FA in CF patients with liver cirrhosis is lacking. This study aimed to assess the FA composition of serum phospholipids in CF patients with and without liver cirrhosis. The study comprised 25 CF patients with liver cirrhosis and 25 without it. We assessed Z-scores for body height and weight, lung function, exocrine pancreatic sufficiency and colonization with Pseudomonas aeruginosa. FAs' profile of serum glycerophospholipids was quantified by gas chromatography mass spectrometry. In CF patients with liver cirrhosis, the levels of C16:0 were higher and the amounts of C20:2n-6, C20:3n-6, C20:4n-6, and all the n-3 polyunsaturated FAs (PUFAs) (C18:3n-3, C20:5n-3, C22:5n-3, C22:6n-3) were lower than those in CF subjects without liver cirrhosis. The n-6/n-3, C20:4n-6/C18:2n-6, total n-6/C18:2n-6, C20:5n-3/C18:3n-3 and total n-3/C18:3n-3 ratios did not differ between the 2 groups. Liver cirrhosis may associate with profound abnormalities in the composition of serum glycerophospholipids FAs in CF patients. None of the analyzed clinical factors could explain the greater prevalence of low levels of PUFAs in this CF subgroup. © 2017 S. Karger AG, Basel.

The fifth transmembrane domain of angiotensin II Type 1 receptor participates in the formation of the ligand-binding pocket and undergoes a counterclockwise rotation upon receptor activation.

PubMed

Domazet, Ivana; Martin, Stéphane S; Holleran, Brian J; Morin, Marie-Eve; Lacasse, Patrick; Lavigne, Pierre; Escher, Emanuel; Leduc, Richard; Guillemette, Gaétan

2009-11-13

The octapeptide hormone angiotensin II exerts a wide variety of cardiovascular effects through the activation of the angiotensin II Type 1 (AT(1)) receptor, which belongs to the G protein-coupled receptor superfamily. Like other G protein- coupled receptors, the AT(1) receptor possesses seven transmembrane domains that provide structural support for the formation of the ligand-binding pocket. The role of the fifth transmembrane domain (TMD5) was investigated using the substituted cysteine accessibility method. All of the residues within Thr-190 to Leu-217 region were mutated one at a time to cysteine, and after expression in COS-7 cells, the mutant receptors were treated with the sulfhydryl-specific alkylating agent methanethiosulfonate-ethylammonium (MTSEA). MTSEA reacts selectively with water-accessible, free sulfhydryl groups of endogenous or introduced point mutation cysteines. If a cysteine is found in the binding pocket, the covalent modification will affect the binding kinetics of the ligand. MTSEA substantially decreased the binding affinity of L197C-AT(1), N200C-AT(1), I201C-AT(1), G203C-AT(1), and F204C-AT(1) mutant receptors, which suggests that these residues orient themselves within the water-accessible binding pocket of the AT(1) receptor. Interestingly, this pattern of acquired MTSEA sensitivity was altered for TMD5 reporter cysteines engineered in a constitutively active N111G-AT(1) receptor background. Indeed, mutant I201C-N111G-AT(1) became more sensitive to MTSEA, whereas mutant G203C-N111G-AT(1) lost some sensitivity. Our results suggest that constitutive activation of AT(1) receptor causes an apparent counterclockwise rotation of TMD5 as viewed from the extracellular side.

76 FR 36387 - Airworthiness Directives; Airbus Model A300 Series Airplanes; Model A310 Series Airplanes; and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-22

... Original August 12, 2010. A300-29-6064 Original August 12, 2010. A310-29-2099, including Appendix 01... (for Model A300- Original....... August 12, 2010. 600 airplanes). A310-29-2099 (for Model A310 Original..., 2010. A310-29-2099 Original........ August 12, 2010. A310-29-2100 Original........ August 12, 2010...

Plasma and erythrocyte phospholipid fatty acid profile in professional basketball and football players.

PubMed

Tepsic, Jasna; Vucic, Vesna; Arsic, Aleksandra; Blazencic-Mladenovic, Vera; Mazic, Sanja; Glibetic, Marija

2009-10-01

The effect of intensive long-term physical activity on phospholipid fatty acid (FA) composition has not been studied thoroughly. We determined plasma and erythrocyte phospholipid FA status of professional basketball and football players. Our results showed differences in plasma FA profile not only between sportsmen and sedentary subjects, but also between two groups of sportsmen. Plasma FA profile in basketball players showed significantly higher proportion of n-6 FA (20:3, 20:4, and 22:4) and total polyunsaturated FA (PUFA) than controls, while football players had higher palmitoleic acid (16:1) than basketball players and controls. Total PUFA and 22:4 were also higher in basketball than in football players. Erythrocyte FA profile showed no differences between football players and controls. However, basketball players had higher proportion of 18:0 than controls, higher saturated FA and lower 18:2 than two other groups, and higher 22:4 than football players. These findings suggest that long-term intensive exercise and type of sport influence FA profile.

Air Force Procedure for Predicting Aircraft Noise Around Airbases: Airbase Operations Program (BASEOPS) Description

DTIC Science & Technology

1990-01-01

B720B/JT3D-3 JCOM 2 JT3D 9 51 52 53 54 55 0 0 12 DC850 DC-8-50/JT3D-3 JCOM 2 JT3D 10 56 57 58 59 60 61 0 13 DC860 DC-8- 60 /JT30-7 JCOM 2 JT3D 11 62 63 64...B707-320B/JT30-7QN JCOM 3 JT3DQ 8 38 39 40 41 42 43 44 17 DCBQN DC-8- 60 /JT30-70N JCOM 3 JT3DQ 10 62 63 64 65 66 67 68 18 CONCRD CONCORDE/OLY593 JCOM...8 0LY593 14 83 83 83 83 84 84 0 19 DC1010 DC-10-10/CF6- 60 JCOM 11 CF660 15 85 86 87 88 89 90 0 20 DC1030 DC-10-30/CF6-50C2 JCOM 11 CF660 58 203 204

Assessment of essential fatty acid and omega3-fatty acid status by measurement of erythrocyte 20:3omega9 (Mead acid), 22:5omega6/20:4omega6 and 22:5omega6/22:6omega3.

PubMed

Fokkema, M R; Smit, E N; Martini, I A; Woltil, H A; Boersma, E R; Muskiet, F A J

2002-11-01

Early suspicion of essential fatty acid deficiency (EFAD) or omega3-deficiency may rather focus on polyunsaturated fatty acid (PUFA) or long-chain PUFA (LCP) analyses than clinical symptoms. We determined cut-off values for biochemical EFAD, omega3-and omega3/22:6omega3 [docosahexaenoic acid (DHA)]-deficiency by measurement of erythrocyte 20:3omega9 (Mead acid), 22:5omega6/20:4omega6 and 22:5omega6/22:6omega3, respectively. Cut-off values, based on 97.5 percentiles, derived from an apparently healthy omnivorous group (six Dominica breast-fed newborns, 32 breast-fed and 27 formula+LCP-fed Dutch low-birth-weight infants, 31 Jerusalem infants, 33 Dutch 3.5-year-old infants, 69 omnivorous Dutch adults and seven Dominica mothers) and an apparently healthy group with low dietary LCP intake (81 formula-fed Dutch low-birth-weight infants, 12 Dutch vegans). Cut-off values were evaluated by their application in an EFAD suspected group of 108, mostly malnourished, Pakistani children, three pediatric patients with chronic fat-malabsorption (abetal-ipoproteinemia, congenital jejunal and biliary atresia) and one patient with a peroxisomal beta-oxidation disorder. Erythrocyte 20:3omega9, 22:5omega6/20:4omega6 and 22:5omega6/22:6omega3 proved age-dependent up to 0.2 years. Cut-off values for ages above 0.2 years were: 0.46mol% 20:3omega9 for EFAD, 0.068mol/mol 22:5omega6/20:4omega6 for omega3-deficiency, 0.22mol/mol 22:5omega6/22:6omega3 for omega3/DHA-marginality and 0.48mol/mol 22:5omega6/22:6omega3 for omega3/DHA-deficiency. Use of RBC 20:3omega9 and 22:5omega6/20:4omega6 cut-off values identified 20.4% of the Pakistani subjects as EFAD+omega3-deficient, 12.9% as EFAD+omega3-sufficient, 38.9% as EFA-sufficient+omega3-deficient and 27.8% as EFA-sufficient+omega3-sufficient. The patient with the peroxisomal disorder was classified as EFA-sufficient, omega3-sufficient (based on RBC 22:5omega6/20:4omega6) and omega3/DHA-deficient (based on RBC 22:5omega6/22:6omega3). The three other pediatric patients were classified as EFAD, omega3-deficient and omega3/DHA-deficient. Use of the combination of the present cut-off values for EFA, omega3 and omega3/DHA status assessment, as based on 97.5 percentiles, may serve for PUFA supplement intervention until better concepts have emerged.

Rapid resolution liquid chromatography coupled with quadrupole time-of-flight mass spectrometry-based metabolomics approach to study the effects of jieduquyuziyin prescription on systemic lupus erythematosus.

PubMed

Ding, Xinghong; Hu, Jinbo; Wen, Chengping; Ding, Zhishan; Yao, Li; Fan, Yongsheng

2014-01-01

Jieduquyuziyin prescription (JP), a traditional Chinese medicine (TCM) prescription, has been widely used for the clinical treatment of systemic lupus erythematosus (SLE). However, the complex chemical constituents of JP and the multifactorial pathogenesis of SLE make research on the therapeutic mechanism of JP in SLE challenging. In this paper, a serum metabolomics approach based on rapid resolution liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (RRLC-Q-TOF/MS) was employed to acquire the metabolic characteristics of serum samples obtained from mice in the SLE model group, JP-treated group, prednisone acetate (PA)-treated group and control group. The orthogonal partial least squares (OPLS) was applied to recognize metabolic patterns, and an obvious separation of groups was obtained. Thirteen metabolites, namely, phosphatidylethanolamine (PE 20:3), hepoxilin B3, lyso- phosphatidylethanolamine (lyso-PE 22:6), 12S-hydroxypentaenoic acid (12S-HEPE), traumatic acid, serotonin, platelet-activating factor (PAF), phosphatidylcholine (PC 20:5),eicosapentaenoic acid (EPA), 12(S)-hydroxyei- cosatetraenoic acid (12S-HETE), 14-hydroxy docosahexaenoic acid (14-HDOHE), lyso-phosphatidylcholine (lyso-PC 20:4), and indole acetaldehyde, were identified and characterized as differential metabolites involved in the pathogenesis of SLE. After treatment with JP, the relative content of 12(S)-HETE, PAF, 12(S)-HEPE, EPA, PE (20:3), Lyso-PE(22:6), and 14-HDOHE were effectively regulated, which suggested that the therapeutic effects of JP on SLE may involve regulating disturbances to the metabolism of unsaturated fatty acid, tryptophan and phospholipid. This research also demonstrated that metabolomics is a powerful tool for researching complex disease mechanisms and evaluating the mechanism of action of TCM.

Treatment of linear mandibular fractures using a single 2.0-mm AO locking reconstruction plate: is a second plate necessary?

PubMed

Scolozzi, Paolo; Martinez, Alvaro; Jaques, Bertrand

2009-12-01

To prospectively evaluate the use of a single Arbeitsgemeinschaft für Osteosynthesefragen (AO) 2.0-mm locking reconstruction plate for linear noncomminuted mandibular fractures without the use of a second plate. We analyzed the clinical and radiologic data of 45 patients with 74 fractures (21 single fractures, 22 double fractures, and 2 triple fractures). Fracture locations were the symphysis (n = 35, 47.3%), body (n = 15, 20.3%), and angle (n = 24, 32.4%). We recorded the mechanism of injury, time between admission to the hospital and surgery, gender and age, temporary maxillomandibular fixation and its duration, and the surgical approach. Postsurgical complications that were recorded as minor did not require surgical intervention, whereas major complications required further surgical intervention. All patients had satisfactory fracture reduction and a successful treatment outcome without major complications. Ten patients (22.2%) developed minor complications. The present study has demonstrated that treating linear noncomminuted mandibular fractures with a single AO 2.0-mm locking reconstruction plates is associated with no major complications and sound bone healing in all patients.

Association of BRAFV600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers

PubMed Central

Aragon Han, Patricia; Kim, Hyun-seok; Cho, Soonweng; Fazeli, Roghayeh; Najafian, Alireza; Khawaja, Hunain; McAlexander, Melissa; Dy, Benzon; Sorensen, Meredith; Aronova, Anna; Sebo, Thomas J.; Giordano, Thomas J.; Fahey, Thomas J.; Thompson, Geoffrey B.; Gauger, Paul G.; Somervell, Helina; Bishop, Justin A.; Eshleman, James R.; Schneider, Eric B.; Witwer, Kenneth W.; Umbricht, Christopher B.

2016-01-01

Background: Studies have demonstrated an association of the BRAFV600E mutation and microRNA (miR) expression with aggressive clinicopathologic features in papillary thyroid cancer (PTC). Analysis of BRAFV600E mutations with miR expression data may improve perioperative decision making for patients with PTC, specifically in identifying patients harboring central lymph node metastases (CLNM). Methods: Between January 2012 and June 2013, 237 consecutive patients underwent total thyroidectomy and prophylactic central lymph node dissection (CLND) at four endocrine surgery centers. All tumors were tested for the presence of the BRAFV600E mutation and miR-21, miR-146b-3p, miR-146b-5p, miR-204, miR-221, miR-222, and miR-375 expression. Bivariate and multivariable analyses were performed to examine associations between molecular markers and aggressive clinicopathologic features of PTC. Results: Multivariable logistic regression analysis of all clinicopathologic features found miR-146b-3p and miR-146b-5p to be independent predictors of CLNM, while the presence of BRAFV600E almost reached significance. Multivariable logistic regression analysis limited to only predictors available preoperatively (molecular markers, age, sex, and tumor size) found miR-146b-3p, miR-146b-5p, miR-222, and BRAFV600E mutation to predict CLNM independently. While BRAFV600E was found to be associated with CLNM (48% mutated in node-positive cases vs. 28% mutated in node-negative cases), its positive and negative predictive values (48% and 72%, respectively) limit its clinical utility as a stand-alone marker. In the subgroup analysis focusing on only classical variant of PTC cases (CVPTC), undergoing prophylactic lymph node dissection, multivariable logistic regression analysis found only miR-146b-5p and miR-222 to be independent predictors of CLNM, while BRAFV600E was not significantly associated with CLNM. Conclusion: In the patients undergoing prophylactic CLNDs, miR-146b-3p, miR-146b-5p, and miR-222 were found to be predictive of CLNM preoperatively. However, there was significant overlap in expression of these miRs in the two outcome groups. The BRAFV600E mutation, while being a marker of CLNM when considering only preoperative variables among all histological subtypes, is likely not a useful stand-alone marker clinically because the difference between node-positive and node-negative cases was small. Furthermore, it lost significance when examining only CVPTC. Overall, our results speak to the concept and interpretation of statistical significance versus actual applicability of molecular markers, raising questions about their clinical usefulness as individual prognostic markers. PMID:26950846

Fatty acid utilization by young Wistar rats fed a cafeteria diet.

PubMed

Esteve, M; Rafecas, I; Fernández-López, J A; Remesar, X; Alemany, M

1992-12-02

The content and accretion of fatty acids in 30, 45 and 60-day old Wistar rats fed either reference chow or a cafeteria diet has been studied, together with their actual fatty acid intake during that period. Diet had a small overall effect on the pattern of deposition of fatty acids, but the deposition of fat was much higher in cafeteria rats. The fat-rich cafeteria diet allowed the direct incorporation of most fatty acids into lipid storage, whilst chow-feeding activated lipogenesis and the deposition of a shorter chain and more saturated type of fatty acids. During the second month of the rat's life, the elongation pathway as well as delta 9-desaturase became functional, thus helping to shape the pattern of fatty acids actually accrued. The 60-day rats showed a relative impairment in the operation of delta 5-desaturase, since their lipids had a higher C20:4/C20:3 ratio than those of the diet ingested. Cafeteria-diet feeding minimized this effect since the large supply of dietary polyunsaturated fatty acids made the operation of the elongation-desaturase pathways practically unnecessary.

22 CFR 229.310 - Recruitment.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Recruitment. 229.310 Section 229.310 Foreign... and Recruitment Prohibited § 229.310 Recruitment. (a) Nondiscriminatory recruitment. A recipient to which §§ 229.300 through 229.310 apply shall not discriminate on the basis of sex in the recruitment and...

45 CFR 2555.310 - Recruitment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Recruitment. 2555.310 Section 2555.310 Public... Discrimination on the Basis of Sex in Admission and Recruitment Prohibited § 2555.310 Recruitment. (a) Nondiscriminatory recruitment. A recipient to which §§ 2555.300 through 2555.310 apply shall not discriminate on the...

32 CFR 196.310 - Recruitment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Recruitment. 196.310 Section 196.310 National... Discrimination on the Basis of Sex in Admission and Recruitment Prohibited § 196.310 Recruitment. (a) Nondiscriminatory recruitment. A recipient to which §§ 196.300 through 196.310 apply shall not discriminate on the...

10 CFR 5.310 - Recruitment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Recruitment. 5.310 Section 5.310 Energy NUCLEAR REGULATORY... FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Admission and Recruitment Prohibited § 5.310 Recruitment. (a) Nondiscriminatory recruitment. A recipient to which §§ 5.300 through 5.310 apply shall not...

49 CFR 25.310 - Recruitment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Recruitment. 25.310 Section 25.310 Transportation... Recruitment Prohibited § 25.310 Recruitment. (a) Nondiscriminatory recruitment. A recipient to which §§ 25.300 through 25.310 apply shall not discriminate on the basis of sex in the recruitment and admission of...

10 CFR 1042.310 - Recruitment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Recruitment. 1042.310 Section 1042.310 Energy DEPARTMENT... Recruitment Prohibited § 1042.310 Recruitment. (a) Nondiscriminatory recruitment. A recipient to which §§ 1042.300 through 1042.310 apply shall not discriminate on the basis of sex in the recruitment and admission...

45 CFR 618.310 - Recruitment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false Recruitment. 618.310 Section 618.310 Public... Discrimination on the Basis of Sex in Admission and Recruitment Prohibited § 618.310 Recruitment. (a) Nondiscriminatory recruitment. A recipient to which §§ 618.300 through 618.310 apply shall not discriminate on the...

29 CFR 36.310 - Recruitment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true Recruitment. 36.310 Section 36.310 Labor Office of the... FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Admission and Recruitment Prohibited § 36.310 Recruitment. (a) Nondiscriminatory recruitment. A recipient to which §§ 36.300 through 36.310...

31 CFR 28.310 - Recruitment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Recruitment. 28.310 Section 28.310... Basis of Sex in Admission and Recruitment Prohibited § 28.310 Recruitment. (a) Nondiscriminatory recruitment. A recipient to which §§ 28.300 through 28.310 apply shall not discriminate on the basis of sex in...

24 CFR 3.310 - Recruitment.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Recruitment. 3.310 Section 3.310... Discrimination on the Basis of Sex in Admission and Recruitment Prohibited § 3.310 Recruitment. (a) Nondiscriminatory recruitment. A recipient to which §§ 3.300 through 3.310 apply shall not discriminate on the basis...

24 CFR 257.102 - Cross-reference.

Code of Federal Regulations, 2010 CFR

2010-04-01

...; 203.14 Builder's warranty; 203.16 Certificate and contract regarding use of dwelling for transient or hotel purposes; 203.17(d) Maturity; 203.18 Maximum mortgage amounts; 203.18a Solar-energy system; 203...

24 CFR 257.102 - Cross-reference.

Code of Federal Regulations, 2013 CFR

2013-04-01

...; 203.14 Builder's warranty; 203.16 Certificate and contract regarding use of dwelling for transient or hotel purposes; 203.17(d) Maturity; 203.18 Maximum mortgage amounts; 203.18a Solar-energy system; 203...

24 CFR 257.102 - Cross-reference.

Code of Federal Regulations, 2012 CFR

2012-04-01

...; 203.14 Builder's warranty; 203.16 Certificate and contract regarding use of dwelling for transient or hotel purposes; 203.17(d) Maturity; 203.18 Maximum mortgage amounts; 203.18a Solar-energy system; 203...

24 CFR 257.102 - Cross-reference.

Code of Federal Regulations, 2014 CFR

2014-04-01

...; 203.14 Builder's warranty; 203.16 Certificate and contract regarding use of dwelling for transient or hotel purposes; 203.17(d) Maturity; 203.18 Maximum mortgage amounts; 203.18a Solar-energy system; 203...

24 CFR 257.102 - Cross-reference.

Code of Federal Regulations, 2011 CFR

2011-04-01

...; 203.14 Builder's warranty; 203.16 Certificate and contract regarding use of dwelling for transient or hotel purposes; 203.17(d) Maturity; 203.18 Maximum mortgage amounts; 203.18a Solar-energy system; 203...

24 CFR 235.1202 - Cross-reference.

Code of Federal Regulations, 2010 CFR

2010-04-01

... transient or hotel purposes. 203.17Mortgage provisions. 203.18Maximum mortgage amount. 203.18aSolar energy systems. 203.18bIncreased mortgage amount. 203.19Mortgagor's minimum investment. 203.20Agreed interest...

24 CFR 235.1202 - Cross-reference.

Code of Federal Regulations, 2011 CFR

2011-04-01

... transient or hotel purposes. 203.17Mortgage provisions. 203.18Maximum mortgage amount. 203.18aSolar energy systems. 203.18bIncreased mortgage amount. 203.19Mortgagor's minimum investment. 203.20Agreed interest...

24 CFR 235.1202 - Cross-reference.

Code of Federal Regulations, 2012 CFR

2012-04-01

... transient or hotel purposes. 203.17Mortgage provisions. 203.18Maximum mortgage amount. 203.18aSolar energy systems. 203.18bIncreased mortgage amount. 203.19Mortgagor's minimum investment. 203.20Agreed interest...

24 CFR 235.1202 - Cross-reference.

Code of Federal Regulations, 2013 CFR

2013-04-01

... transient or hotel purposes. 203.17Mortgage provisions. 203.18Maximum mortgage amount. 203.18aSolar energy systems. 203.18bIncreased mortgage amount. 203.19Mortgagor's minimum investment. 203.20Agreed interest...

24 CFR 235.1202 - Cross-reference.

Code of Federal Regulations, 2014 CFR

2014-04-01

... transient or hotel purposes. 203.17Mortgage provisions. 203.18Maximum mortgage amount. 203.18aSolar energy systems. 203.18bIncreased mortgage amount. 203.19Mortgagor's minimum investment. 203.20Agreed interest...

78 FR 80379 - Federal Acquisition Regulation; Trade Agreements Thresholds

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-31

... 79,507 79,507 10,335,931 Oman FTA 204,000 204,000 10,335,931 Panama FTA 204,000 204,000 7,864,000...,335,931 --Mexico 79,507 79,507 10,335,931 Oman FTA 204,000 204,000 10,335,931 Panama FTA 204,000 204...

Low Simulated Radiation Limit for Runaway Greenhouse Climates

NASA Technical Reports Server (NTRS)

Goldblatt, Colin; Robinson, Tyler D.; Zahnle, Kevin J.; Crisp, David

2013-01-01

Terrestrial planet atmospheres must be in long-term radiation balance, with solar radiation absorbed matched by thermal radiation emitted. For hot moist atmospheres, however, there is an upper limit on the thermal emission which is decoupled from the surface temperature. If net absorbed solar radiation exceeds this limit the planet will heat uncontrollably, the so-called \\runaway greenhouse". Here we show that a runaway greenhouse induced steam atmosphere may be a stable state for a planet with the same amount of incident solar radiation as Earth has today, contrary to previous results. We have calculated the clear-sky radiation limits at line-by-line spectral resolution for the first time. The thermal radiation limit is lower than previously reported (282 W/sq m rather than 310W/sq m) and much more solar radiation would be absorbed (294W/sq m rather than 222W/sq m). Avoiding a runaway greenhouse under the present solar constant requires that the atmosphere is subsaturated with water, and that cloud albedo forcing exceeds cloud greenhouse forcing. Greenhouse warming could in theory trigger a runaway greenhouse but palaeoclimate comparisons suggest that foreseeable increases in greenhouse gases will be insufficient to do this.

9 CFR 203.8-203.9 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false [Reserved] 203.8-203.9 Section 203.8-203.9 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS ADMINISTRATION (PACKERS AND... ACT §§ 203.8-203.9 [Reserved] ...

6 CFR 17.310 - Recruitment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Recruitment. 17.310 Section 17.310 Domestic... in Admission and Recruitment Prohibited § 17.310 Recruitment. (a) Nondiscriminatory recruitment. A... recruitment and admission of students. A recipient may be required to undertake additional recruitment efforts...

14 CFR 1253.310 - Recruitment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Recruitment. 1253.310 Section 1253.310... in Admission and Recruitment Prohibited § 1253.310 Recruitment. (a) Nondiscriminatory recruitment. A... recruitment and admission of students. A recipient may be required to undertake additional recruitment efforts...

Prevalence of Toxoplasma gondii antibodies among veterinary college staff and students, Iowa State University.

PubMed Central

1976-01-01

Serum samples obtained from two groups within the College of Veterinary Medicine, Iowa State University, were examined for Toxoplasma gondii antibodies. Serum samples from 65 (26.0%) of the 250 persons examined yielded a titer of 1:16 or greater by the indirect fluorescent antibody test. A prevalence of 33.3% was obtained for 108 Veterinary Medical Research Institute (VMRI) personnel. Fof 142 veterinary students, the reactive rate was 20.4%. There was a marked difference of results within the student group--the reactive rate of 31.0% of 58 members of the class of 1975 was significantly higher (p less than 0.05) than the 13.1% for 84 members of the class of 1976. Studies on multiple serum samples were carried out on 55 VMRI personnel; 17 showed a change in serologic reactivity but only 5 had titers of 1:64 or greater. No definitive relationships could be determined between the epidemiologic characteristics examined and the presence of T. gondii antibodies. Characteristics examined included age, sex, primary residency, food habits (eating of rare beef and smoked pork products), and extent of animal contact. Images p526-a PMID:825918

Active immunization with the peptide epitope vaccine Aβ3-10-KLH induces a Th2-polarized anti-Aβ antibody response and decreases amyloid plaques in APP/PS1 transgenic mice.

PubMed

Ding, Li; Meng, Yuan; Zhang, Hui-Yi; Yin, Wen-Chao; Yan, Yi; Cao, Yun-Peng

2016-11-10

Active amyloid-β (Aβ) immunotherapy is effective in preventing Aβ deposition, facilitating plaque clearance, and improving cognitive functions in mouse models of Alzheimer's disease (AD). Developing a safe and effective AD vaccine requires a delicate balance between inducing adequate humoral immune responses and avoiding T cell-mediated autoimmune responses. In this study, we designed 2 peptide epitope vaccines, Aβ3-10-KLH and 5Aβ3-10, prepared respectively by coupling Aβ3-10 to the immunogenic carrier protein keyhole limpet hemocyanin (KLH) or by joining 5 Aβ3-10 epitopes linearly in tandem. Young APP/PS1 mice were immunized subcutaneously with Aβ3-10-KLH or 5Aβ3-10 mixed with Freund's adjuvant, and the immunopotencies of these Aβ3-10 peptide vaccines were tested. Aβ3-10-KLH elicited a robust Th2-polarized anti-Aβ antibody response and inhibited Aβ deposition in APP/PS1 mice. However, 5Aβ3-10 did not induce an effective humoral immune response. These results indicated that Aβ3-10-KLH may be a safe and efficient vaccine for AD and that conjugating the antigen to a carrier protein may be more effective than linking multiple peptide antigens in tandem in applications for antibody production and vaccine preparation. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Surgical treatment for male prolactinoma

PubMed Central

Song, Yi-Jun; Chen, Mei-Ting; Lian, Wei; Xing, Bing; Yao, Yong; Feng, Ming; Wang, Ren-Zhi

2017-01-01

Abstract A total of 184 cases of surgically treated male prolactinoma were analyzed retrospectively to summarize the outcome of this surgical intervention. We analyzed the general characteristics, clinical manifestations, hormone levels, imaging features, preoperative treatments, surgical outcomes, pathology results, and follow-up records for all included patients. The most common clinical manifestations included sexual dysfunction (47.4%), headache (55.9%), and visual disturbance (46.7%). Serum prolactin levels ranged from 150 to 204,952 ng/mL. Tumor size varied from 6 to 70 mm. Pituitary adenomas grew in a parasellar pattern with visual deficits occurring 40.7% of the time. After surgical therapy, 88.6% of patients achieved symptom relief, and 98.4% experienced an immediate postoperative decline in prolactin level. Fifty-seven patients (31.0%) achieved initial remission, and 26 patients (45.6%) experienced recurrence. Hence, our results suggest that in male prolactinoma characterized by a large pituitary diameter and high serum prolactin level, tumor size predicts the degree of gross resection. The prognostic predictors included preoperative tumor growth pattern and Ki-67 index. Citation: Yi-jun S, Mei-ting C, Wei L, Bing X, Yong Y, Ming F, Ren-zhi W. (2016) Surgical treatment for male prolactinoma: a retrospective study of 184 cases PMID:28079813

12 CFR 222.80-222.81 - [Reserved

Code of Federal Regulations, 2011 CFR

2011-01-01

... 12 Banks and Banking 3 2011-01-01 2011-01-01 false [Reserved] 222.80-222.81 Section 222.80-222.81 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM FAIR CREDIT REPORTING (REGULATION V) Duties of Users of Consumer Reports Regarding Identity Theft § 222...

12 CFR 222.80-222.81 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 3 2010-01-01 2010-01-01 false [Reserved] 222.80-222.81 Section 222.80-222.81 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM FAIR CREDIT REPORTING (REGULATION V) Duties of Users of Consumer Reports Regarding Identity Theft § 222...

15 CFR 8a.310 - Recruitment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Recruitment. 8a.310 Section 8a.310... in Admission and Recruitment Prohibited § 8a.310 Recruitment. (a) Nondiscriminatory recruitment. A... recruitment and admission of students. A recipient may be required to undertake additional recruitment efforts...

Consanguinity Among Parents of Iranian Deaf Children

PubMed Central

Ajallouyan, Mohammad; Radfar, Shokofeh; Nouhi, Sima; Tavallaie, Seid Abbas; Amirsalari, Susan; Yousefi, Jaleh; Hasanali Fard, Mahdieh

2016-01-01

Background It seems that there is a relationship between consanguinity and profound hearing loss but there is little data about the association of consanguinity and hearing loss in Iran. Objectives The aim of this study is to demonstrate the causes of profound bilateral sensorineural hearing loss among Iranian samples who are candidates for cochlear implantation. Methods This study was retrospective, analytical, and designed to collect information about profound hearing impaired cases referred to the Baqiyatallah Cochlear implantation center using enumeration. A total of 310 children with profound hearing impairments participated in this study. They were aged from 6 months to 4 years old. The study was done between January 2007 and April 2009. Chi-square tests were used to show whether there was any statistical difference between the incidence of marital consanguinity of their parents and the normal population. Results Sixty-five percent of those 310 children had parents who had married with their relatives. Of the 203 (65%) parents that had consanguineous marriages, 132 were first cousins, which includes the children of two brothers (37 [11.8%] patrilateral parallel cousins), the children of two sisters (38 [12.2%] multi-lateral parallel cousins), or the children of a brother and a sister (57 [18.3%] cross cousins). Fifty-four (17.4%) of the parents were second cousins and 17 (5.2%) were beyond second cousins. Also, hearing loss etiology was obvious in 237 (76.3%) of the patients with profound hearing loss but was unknown in 73 (23.7%). Hereditary was identified as the most common cause in 33% of the cases. Conclusions Our data demonstrated a 65% occurrence of consanguineous marriage among the parents of deaf children, which is statistically different from the percentage of consanguineous marriage among Iranian population (38%). This indicates an obvious relationship between severe hearing loss and consanguineous marriage. PMID:28191326

Relationships between 222Rn dissolved in ground water supplies and indoor 222Rn concentrations in some Colorado front range houses

USGS Publications Warehouse

Folger, P.F.; Nyberg, P.; Wanty, R.B.; Poeter, E.

1994-01-01

Indoor 222Rn concentrations were measured in 37 houses with alpha track detectors placed in water-use rooms near water sources (bathrooms, laundry rooms, and kitchens) and in non-water-use living rooms, dining rooms, and bedrooms away from water sources. Results show that relative contributions of 222Rn to indoor air from water use are insignificant when soil-gas concentrations are high but become increasingly important as the ratio of 222Rn-in-water:222Rn-in-soil gas increases. High soil-gas 222Rn concentrations may mask 222Rn contributions from water even when waterborne 222Rn concentrations are as high as 750 kBq m-3. Ground water in Precambrian Pikes Peak granite averages 340 kBq m-3222Rn, vs. 170 kBq m-3 in Precambrian migmatite, but average 222Rn concentrations in soil gas are also lower in migmatite. Because the ratio of 222Rn-in- water:222Rn-in-soil gas may be consistently higher for houses in migmatite than in Pikes Peak granite, indoor air in houses built on migmatite may have a greater relative contribution from water use even though average 222Rn concentrations in the water are lower. Continuous monitoring of 222Rn concentrations in air on 15-min intervals also indicates that additions to indoor concentrations from water use are significant and measurable only when soil-gas concentrations are low and concentrations in water are high. When soil-gas concentrations were mitigated to less than 150 Bq m-3 in one house, water contributes 20-40% of the annual indoor 222Rn concentration in the laundry room (222Rn concentration in water of 670 kBq m-3). Conversely, when the mitigation system is inactive, diurnal fluctuations and other variations in the soil-gas 222Rn contribution swamp the variability due to water use in the house. Measurable variations in indoor concentrations from water use were not detected in one house despite a low soil-gas contribution of approximately 150 Bq m-3 because waterborne 222Rn concentrations also are low (80 kBq m-3). This result suggests that 222Rn concentrations in water near the recommended EPA limit in drinking water of 11 kBq m-3 may not contribute measurable amounts of 222Rn to indoor air in most houses.

32 CFR Appendix D to Part 310 - Provisions of the Privacy Act From Which a General or Specific Exemption May Be Claimed

Code of Federal Regulations, 2010 CFR

2010-07-01

... General or Specific Exemption May Be Claimed D Appendix D to Part 310 National Defense Department of.... 310, App. D Appendix D to Part 310—Provisions of the Privacy Act From Which a General or Specific Exemption May Be Claimed (See paragraph (d) of § 310.26 ) Exemptions (j)(2) (k) (1-7) Section of the Privacy...

40 CFR 52.730 - Compliance schedules.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Pollution Control Regulations Rule 203(d)(4), 203(d)(6)(B)(ii)(bb), 203(g)(1)(B), 203(g)(2), 203(g)(3), 203... operator of any stationary source subject to Illinois Air Pollution Control Regulation Rule 203(d)(4) shall... or operator of any stationary source subject to Illinois Air Pollution Control Regulation Rule 203(d...

40 CFR 52.730 - Compliance schedules.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Pollution Control Regulations Rule 203(d)(4), 203(d)(6)(B)(ii)(bb), 203(g)(1)(B), 203(g)(2), 203(g)(3), 203... operator of any stationary source subject to Illinois Air Pollution Control Regulation Rule 203(d)(4) shall... or operator of any stationary source subject to Illinois Air Pollution Control Regulation Rule 203(d...

40 CFR 52.730 - Compliance schedules.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Pollution Control Regulations Rule 203(d)(4), 203(d)(6)(B)(ii)(bb), 203(g)(1)(B), 203(g)(2), 203(g)(3), 203... operator of any stationary source subject to Illinois Air Pollution Control Regulation Rule 203(d)(4) shall... or operator of any stationary source subject to Illinois Air Pollution Control Regulation Rule 203(d...

38 CFR 21.310 - Rate of pursuit of a rehabilitation program.

Code of Federal Regulations, 2011 CFR

2011-07-01

... rehabilitation program. 21.310 Section 21.310 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) VOCATIONAL REHABILITATION AND EDUCATION Vocational Rehabilitation and Employment Under 38 U.S.C. Chapter 31 Rate of Pursuit § 21.310 Rate of pursuit of a rehabilitation program. (a...

32 CFR 310.12 - Government contractors.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false Government contractors. 310.12 Section 310.12... PROGRAM DOD PRIVACY PROGRAM Systems of Records § 310.12 Government contractors. (a) Applicability to government contractors. (1) When a DoD Component contract requires the operation or maintenance of a system...

32 CFR 310.12 - Government contractors.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 2 2013-07-01 2013-07-01 false Government contractors. 310.12 Section 310.12... PROGRAM DOD PRIVACY PROGRAM Systems of Records § 310.12 Government contractors. (a) Applicability to government contractors. (1) When a DoD Component contract requires the operation or maintenance of a system...

32 CFR 310.12 - Government contractors.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 2 2011-07-01 2011-07-01 false Government contractors. 310.12 Section 310.12... PROGRAM DOD PRIVACY PROGRAM Systems of Records § 310.12 Government contractors. (a) Applicability to government contractors. (1) When a DoD Component contract requires the operation or maintenance of a system...

32 CFR 310.12 - Government contractors.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 2 2012-07-01 2012-07-01 false Government contractors. 310.12 Section 310.12... PROGRAM DOD PRIVACY PROGRAM Systems of Records § 310.12 Government contractors. (a) Applicability to government contractors. (1) When a DoD Component contract requires the operation or maintenance of a system...

20 CFR 405.310 - How to request a hearing before an administrative law judge.

Code of Federal Regulations, 2010 CFR

2010-04-01

... administrative law judge. 405.310 Section 405.310 Employees' Benefits SOCIAL SECURITY ADMINISTRATION ADMINISTRATIVE REVIEW PROCESS FOR ADJUDICATING INITIAL DISABILITY CLAIMS Administrative Law Judge Hearing § 405.310 How to request a hearing before an administrative law judge. (a) Written request. You must request...

32 CFR 310.12 - Government contractors.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Government contractors. 310.12 Section 310.12... PROGRAM DOD PRIVACY PROGRAM Systems of Records § 310.12 Government contractors. (a) Applicability to government contractors. (1) When a DoD Component contract requires the operation or maintenance of a system...

19 CFR 351.310 - Hearings.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 3 2010-04-01 2010-04-01 false Hearings. 351.310 Section 351.310 Customs Duties... Argument § 351.310 Hearings. (a) Introduction. This section sets forth the procedures for requesting a hearing, indicates that the Secretary may consolidate hearings, and explains when the Secretary may hold...

46 CFR 310.56 - Physical requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 8 2012-10-01 2012-10-01 false Physical requirements. 310.56 Section 310.56 Shipping... Training of Midshipmen at the United States Merchant Marine Academy § 310.56 Physical requirements. (a) Physical standards. (1) A candidate shall meet the physical requirements prescribed by the Department of...

46 CFR 310.56 - Physical requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 8 2014-10-01 2014-10-01 false Physical requirements. 310.56 Section 310.56 Shipping... Training of Midshipmen at the United States Merchant Marine Academy § 310.56 Physical requirements. (a) Physical standards. (1) A candidate shall meet the physical requirements prescribed by the Department of...

46 CFR 310.56 - Physical requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 8 2011-10-01 2011-10-01 false Physical requirements. 310.56 Section 310.56 Shipping... Training of Midshipmen at the United States Merchant Marine Academy § 310.56 Physical requirements. (a) Physical standards. (1) A candidate shall meet the physical requirements prescribed by the Department of...

46 CFR 310.56 - Physical requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 8 2013-10-01 2013-10-01 false Physical requirements. 310.56 Section 310.56 Shipping... Training of Midshipmen at the United States Merchant Marine Academy § 310.56 Physical requirements. (a) Physical standards. (1) A candidate shall meet the physical requirements prescribed by the Department of...

18 CFR 385.204 - Applications (Rule 204).

Code of Federal Regulations, 2010 CFR

2010-04-01

....204 Applications (Rule 204). Any person seeking a license, permit, certification, or similar authorization or permission, must file an application to obtain that authorization or permission. ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Applications (Rule 204...

21 CFR 1305.12 - Procedure for executing DEA Forms 222.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Procedure for executing DEA Forms 222. 1305.12... I AND II CONTROLLED SUBSTANCES DEA Form 222 § 1305.12 Procedure for executing DEA Forms 222. (a) A purchaser must prepare and execute a DEA Form 222 simultaneously in triplicate by means of interleaved...

21 CFR 1305.12 - Procedure for executing DEA Forms 222.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 9 2011-04-01 2011-04-01 false Procedure for executing DEA Forms 222. 1305.12... I AND II CONTROLLED SUBSTANCES DEA Form 222 § 1305.12 Procedure for executing DEA Forms 222. (a) A purchaser must prepare and execute a DEA Form 222 simultaneously in triplicate by means of interleaved...

24 CFR 203.439a - Mortgages on property in Allegany Reservation of Seneca Nation of Indians authorized by section...

Code of Federal Regulations, 2011 CFR

2011-04-01

... Reservation of Seneca Nation of Indians authorized by section 203(q) of the National Housing Act. 203.439a... Indians authorized by section 203(q) of the National Housing Act. (a) Applicability. This section shall apply to mortgages authorized by section 203(q) of the National Housing Act (§ 203.43j of this part...

24 CFR 203.439a - Mortgages on property in Allegany Reservation of Seneca Nation of Indians authorized by section...

Code of Federal Regulations, 2012 CFR

2012-04-01

... Reservation of Seneca Nation of Indians authorized by section 203(q) of the National Housing Act. 203.439a... Indians authorized by section 203(q) of the National Housing Act. (a) Applicability. This section shall apply to mortgages authorized by section 203(q) of the National Housing Act (§ 203.43j of this part...

24 CFR 203.439a - Mortgages on property in Allegany Reservation of Seneca Nation of Indians authorized by section...

Code of Federal Regulations, 2014 CFR

2014-04-01

... Reservation of Seneca Nation of Indians authorized by section 203(q) of the National Housing Act. 203.439a... Indians authorized by section 203(q) of the National Housing Act. (a) Applicability. This section shall apply to mortgages authorized by section 203(q) of the National Housing Act (§ 203.43j of this part...

24 CFR 203.439a - Mortgages on property in Allegany Reservation of Seneca Nation of Indians authorized by section...

Code of Federal Regulations, 2010 CFR

2010-04-01

... Reservation of Seneca Nation of Indians authorized by section 203(q) of the National Housing Act. 203.439a... Indians authorized by section 203(q) of the National Housing Act. (a) Applicability. This section shall apply to mortgages authorized by section 203(q) of the National Housing Act (§ 203.43j of this part...

24 CFR 203.439a - Mortgages on property in Allegany Reservation of Seneca Nation of Indians authorized by section...

Code of Federal Regulations, 2013 CFR

2013-04-01

... Reservation of Seneca Nation of Indians authorized by section 203(q) of the National Housing Act. 203.439a... Indians authorized by section 203(q) of the National Housing Act. (a) Applicability. This section shall apply to mortgages authorized by section 203(q) of the National Housing Act (§ 203.43j of this part...

48 CFR 252.222-7002 - Compliance with local labor laws (overseas).

Code of Federal Regulations, 2010 CFR

2010-10-01

... labor laws (overseas). 252.222-7002 Section 252.222-7002 Federal Acquisition Regulations System DEFENSE... CLAUSES Text of Provisions And Clauses 252.222-7002 Compliance with local labor laws (overseas). As prescribed in 222.7201(a), use the following clause: Compliance with Local Labor Laws (Overseas) (JUN 1997...

24 CFR 203.203 - Issuance and nature of insured 10-year protection plans.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Issuance and nature of insured 10-year protection plans. 203.203 Section 203.203 Housing and Urban Development Regulations Relating to... Underwriting Procedures Insured Ten-Year Protection Plans (plan) § 203.203 Issuance and nature of insured 10...

24 CFR 203.203 - Issuance and nature of insured 10-year protection plans.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Issuance and nature of insured 10-year protection plans. 203.203 Section 203.203 Housing and Urban Development Regulations Relating to... Underwriting Procedures Insured Ten-Year Protection Plans (plan) § 203.203 Issuance and nature of insured 10...

24 CFR 203.203 - Issuance and nature of insured 10-year protection plans.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Issuance and nature of insured 10-year protection plans. 203.203 Section 203.203 Housing and Urban Development Regulations Relating to... Underwriting Procedures Insured Ten-Year Protection Plans (plan) § 203.203 Issuance and nature of insured 10...

24 CFR 203.203 - Issuance and nature of insured 10-year protection plans.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Issuance and nature of insured 10-year protection plans. 203.203 Section 203.203 Housing and Urban Development Regulations Relating to... Underwriting Procedures Insured Ten-Year Protection Plans (plan) § 203.203 Issuance and nature of insured 10...

24 CFR 203.203 - Issuance and nature of insured 10-year protection plans.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Issuance and nature of insured 10-year protection plans. 203.203 Section 203.203 Housing and Urban Development Regulations Relating to... Underwriting Procedures Insured Ten-Year Protection Plans (plan) § 203.203 Issuance and nature of insured 10...

45 CFR 2541.310 - Real property.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Real property. 2541.310 Section 2541.310 Public... Changes, Property and Subawards § 2541.310 Real property. (a) Title. Subject to the obligations and conditions set forth in this section, title to real property acquired under a grant or subgrant will vest...

45 CFR 2541.310 - Real property.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 4 2013-10-01 2013-10-01 false Real property. 2541.310 Section 2541.310 Public... Changes, Property and Subawards § 2541.310 Real property. (a) Title. Subject to the obligations and conditions set forth in this section, title to real property acquired under a grant or subgrant will vest...

45 CFR 2541.310 - Real property.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 4 2014-10-01 2014-10-01 false Real property. 2541.310 Section 2541.310 Public... Changes, Property and Subawards § 2541.310 Real property. (a) Title. Subject to the obligations and conditions set forth in this section, title to real property acquired under a grant or subgrant will vest...

45 CFR 2541.310 - Real property.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 4 2012-10-01 2012-10-01 false Real property. 2541.310 Section 2541.310 Public... Changes, Property and Subawards § 2541.310 Real property. (a) Title. Subject to the obligations and conditions set forth in this section, title to real property acquired under a grant or subgrant will vest...

45 CFR 2541.310 - Real property.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 4 2011-10-01 2011-10-01 false Real property. 2541.310 Section 2541.310 Public... Changes, Property and Subawards § 2541.310 Real property. (a) Title. Subject to the obligations and conditions set forth in this section, title to real property acquired under a grant or subgrant will vest...

10 CFR 35.310 - Safety instruction.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 1 2011-01-01 2011-01-01 false Safety instruction. 35.310 Section 35.310 Energy NUCLEAR... Required § 35.310 Safety instruction. In addition to the requirements of § 19.12 of this chapter, (a) A licensee shall provide radiation safety instruction, initially and at least annually, to personnel caring...

45 CFR 164.310 - Physical safeguards.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 1 2011-10-01 2011-10-01 false Physical safeguards. 164.310 Section 164.310... Information § 164.310 Physical safeguards. A covered entity must, in accordance with § 164.306: (a)(1) Standard: Facility access controls. Implement policies and procedures to limit physical access to its...

45 CFR 164.310 - Physical safeguards.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 1 2012-10-01 2012-10-01 false Physical safeguards. 164.310 Section 164.310... Information § 164.310 Physical safeguards. A covered entity must, in accordance with § 164.306: (a)(1) Standard: Facility access controls. Implement policies and procedures to limit physical access to its...

45 CFR 164.310 - Physical safeguards.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Physical safeguards. 164.310 Section 164.310... Information § 164.310 Physical safeguards. A covered entity must, in accordance with § 164.306: (a)(1) Standard: Facility access controls. Implement policies and procedures to limit physical access to its...

10 CFR 35.310 - Safety instruction.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Safety instruction. 35.310 Section 35.310 Energy NUCLEAR... Required § 35.310 Safety instruction. In addition to the requirements of § 19.12 of this chapter, (a) A licensee shall provide radiation safety instruction, initially and at least annually, to personnel caring...

30 CFR 77.310 - Control panels.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Control panels. 77.310 Section 77.310 Mineral....310 Control panels. (a) All thermal dryer system control panels constructed after June 30, 1971 shall... manner as to minimize vibration. (b) A schematic diagram containing legends which show the location of...

30 CFR 77.310 - Control panels.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Control panels. 77.310 Section 77.310 Mineral....310 Control panels. (a) All thermal dryer system control panels constructed after June 30, 1971 shall... manner as to minimize vibration. (b) A schematic diagram containing legends which show the location of...

36 CFR 1211.310 - Recruitment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Recruitment. 1211.310 Section... Discrimination on the Basis of Sex in Admission and Recruitment Prohibited § 1211.310 Recruitment. (a) Nondiscriminatory recruitment. A recipient to which §§ 1211.300 through 1211.310 apply shall not discriminate on the...

13 CFR 113.310 - Recruitment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Recruitment. 113.310 Section 113... Discrimination on the Basis of Sex in Admission and Recruitment Prohibited § 113.310 Recruitment. (a) Nondiscriminatory recruitment. A recipient to which §§ 113.300 through 113.310 apply shall not discriminate on the...

18 CFR 1317.310 - Recruitment.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Recruitment. 1317.310... Discrimination on the Basis of Sex in Admission and Recruitment Prohibited § 1317.310 Recruitment. (a) Nondiscriminatory recruitment. A recipient to which §§ 1317.300 through 1317.310 apply shall not discriminate on the...

38 CFR 23.310 - Recruitment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Recruitment. 23.310... Discrimination on the Basis of Sex in Admission and Recruitment Prohibited § 23.310 Recruitment. (a) Nondiscriminatory recruitment. A recipient to which §§ 23.300 through 23.310 apply shall not discriminate on the...

24 CFR 4001.102 - Cross-reference.

Code of Federal Regulations, 2014 CFR

2014-04-01

... contract regarding use of dwelling for transient or hotel purposes; 203.17(d) Maturity; 203.18 Maximum mortgage amounts; 203.18a Solar-energy system; 203.18b Increased mortgage amount; 203.18c One-time or up...

24 CFR 4001.102 - Cross-reference.

Code of Federal Regulations, 2013 CFR

2013-04-01

... contract regarding use of dwelling for transient or hotel purposes; 203.17(d) Maturity; 203.18 Maximum mortgage amounts; 203.18a Solar-energy system; 203.18b Increased mortgage amount; 203.18c One-time or up...

24 CFR 4001.102 - Cross-reference.

Code of Federal Regulations, 2011 CFR

2011-04-01

... contract regarding use of dwelling for transient or hotel purposes; 203.17(d) Maturity; 203.18 Maximum mortgage amounts; 203.18a Solar-energy system; 203.18b Increased mortgage amount; 203.18c One-time or up...

24 CFR 4001.102 - Cross-reference.

Code of Federal Regulations, 2010 CFR

2010-04-01

... contract regarding use of dwelling for transient or hotel purposes; 203.17(d) Maturity; 203.18 Maximum mortgage amounts; 203.18a Solar-energy system; 203.18b Increased mortgage amount; 203.18c One-time or up...

24 CFR 4001.102 - Cross-reference.

Code of Federal Regulations, 2012 CFR

2012-04-01

... contract regarding use of dwelling for transient or hotel purposes; 203.17(d) Maturity; 203.18 Maximum mortgage amounts; 203.18a Solar-energy system; 203.18b Increased mortgage amount; 203.18c One-time or up...

COH-203, a novel microtubule inhibitor, exhibits potent anti-tumor activity via p53-dependent senescence in hepatocellular carcinoma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Qi, Huan; Zuo, Dai-Ying; Bai, Zhao-Shi

Highlights: • COH-203 exhibits anti-hepatoma effects in vitro and in vivo with low toxicity. • COH-203 inhibits tubulin polymerization. • COH-203 induces mitotic arrest followed by mitotic slippage in BEL-7402 cells. • COH-203 induces p53-dependent senescence in BEL-7402 cells. - Abstract: 5-(3-Hydroxy-4-methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-3H-1, 2-dithiol-3-one (COH-203) is a novel synthesized analogue of combretastatin A-4 that can be classified as a microtubule inhibitor. In this study, we evaluated the anti-hepatoma effect of COH-203 in vitro and in vivo and explored the underlying molecular mechanisms. COH-203 was shown to be more effective in inhibiting the proliferation of liver cancer cells compared with normal livermore » cells. COH-203 also displayed potent anti-tumor activity in a hepatocellular carcinoma xenograft model without significant toxicity. Mechanistic studies demonstrated that treatment with COH-203 induced mitotic arrest by inhibiting tubulin polymerization in BEL-7402 liver cancer cells. Long-term COH-203 treatment in BEL-7402 cells led to mitotic slippage followed by senescence via the p14{sup Arf}–p53–p21 and p16{sup INK4α}–Rb pathways. Furthermore, suppression of p53 via pifithrin-α (p53 inhibitor) and p53-siRNA attenuated COH-203-induced senescence in BEL-7402 cells, suggesting that COH-203 induced senescence p53-dependently. In conclusion, we report for the first time that COH-203, one compound in the combretastatin family, promotes anti-proliferative activity through the induction of p-53 dependent senescence. Our findings will provide a molecular rationale for the development of COH-203 as a promising anti-tumor agent.« less

46 CFR 310.66 - Foreign students.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false Foreign students. 310.66 Section 310.66 Shipping... Training of Midshipmen at the United States Merchant Marine Academy § 310.66 Foreign students. (a..., country clearances, travel papers, transportation to the Academy, obtaining the necessary designation by...

32 CFR 310.7 - Information requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false Information requirements. 310.7 Section 310.7 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY... § 310.6(d)(7) are assigned Report Control Symbol DD-DA&M(A)1379. ...

32 CFR 310.7 - Information requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Information requirements. 310.7 Section 310.7 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY... § 310.6(d)(7) are assigned Report Control Symbol DD-DA&M(A)1379. ...

32 CFR 310.7 - Information requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 2 2011-07-01 2011-07-01 false Information requirements. 310.7 Section 310.7 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY... § 310.6(d)(7) are assigned Report Control Symbol DD-DA&M(A)1379. ...

32 CFR 310.7 - Information requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 2 2012-07-01 2012-07-01 false Information requirements. 310.7 Section 310.7 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY... § 310.6(d)(7) are assigned Report Control Symbol DD-DA&M(A)1379. ...

32 CFR 310.7 - Information requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 2 2013-07-01 2013-07-01 false Information requirements. 310.7 Section 310.7 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY... § 310.6(d)(7) are assigned Report Control Symbol DD-DA&M(A)1379. ...

46 CFR 310.56 - Physical requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... facility designated by the Service Academies Central Medical Review Board. The required physical... 46 Shipping 8 2010-10-01 2010-10-01 false Physical requirements. 310.56 Section 310.56 Shipping... Training of Midshipmen at the United States Merchant Marine Academy § 310.56 Physical requirements. (a...

46 CFR 130.310 - Radar.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 4 2011-10-01 2011-10-01 false Radar. 130.310 Section 130.310 Shipping COAST GUARD... EQUIPMENT AND SYSTEMS Navigational Equipment § 130.310 Radar. Each vessel of 100 or more gross tons must be fitted with a general marine radar in the pilothouse. ...

46 CFR 130.310 - Radar.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Radar. 130.310 Section 130.310 Shipping COAST GUARD... EQUIPMENT AND SYSTEMS Navigational Equipment § 130.310 Radar. Each vessel of 100 or more gross tons must be fitted with a general marine radar in the pilothouse. ...

46 CFR 130.310 - Radar.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 4 2013-10-01 2013-10-01 false Radar. 130.310 Section 130.310 Shipping COAST GUARD... EQUIPMENT AND SYSTEMS Navigational Equipment § 130.310 Radar. Each vessel of 100 or more gross tons must be fitted with a general marine radar in the pilothouse. ...

46 CFR 130.310 - Radar.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 4 2014-10-01 2014-10-01 false Radar. 130.310 Section 130.310 Shipping COAST GUARD... EQUIPMENT AND SYSTEMS Navigational Equipment § 130.310 Radar. Each vessel of 100 or more gross tons must be fitted with a general marine radar in the pilothouse. ...

46 CFR 130.310 - Radar.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 4 2012-10-01 2012-10-01 false Radar. 130.310 Section 130.310 Shipping COAST GUARD... EQUIPMENT AND SYSTEMS Navigational Equipment § 130.310 Radar. Each vessel of 100 or more gross tons must be fitted with a general marine radar in the pilothouse. ...

30 CFR 203.78 - Do I keep relief approved by MMS under §§ 203.60-203.77 for my lease, unit or project if prices...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Do I keep relief approved by MMS under §§ 203.60-203.77 for my lease, unit or project if prices rise significantly? 203.78 Section 203.78 Mineral....77 for my lease, unit or project if prices rise significantly? If prices rise above a base price...

76 FR 421 - Airworthiness Directives; Airbus Model A310 Series Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-05

... accordance with the Accomplishment Instructions of Airbus Service Bulletin A310-27-2099, dated February 17, 2006; or Airbus Mandatory Service Bulletin A310-27-2099, Revision 01, dated March 21, 2008. Repeat the..., use only Airbus Mandatory Service Bulletin A310-27- 2099, Revision 01, dated March 21, 2008. Note 1...

46 CFR 197.310 - Air compressor system.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Air compressor system. 197.310 Section 197.310 Shipping... GENERAL PROVISIONS Commercial Diving Operations Equipment § 197.310 Air compressor system. A compressor used to supply breathing air to a diver must have— (a) A volume tank that is— (1) Built and stamped in...

46 CFR 197.310 - Air compressor system.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Air compressor system. 197.310 Section 197.310 Shipping... GENERAL PROVISIONS Commercial Diving Operations Equipment § 197.310 Air compressor system. A compressor used to supply breathing air to a diver must have— (a) A volume tank that is— (1) Built and stamped in...

46 CFR 197.310 - Air compressor system.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Air compressor system. 197.310 Section 197.310 Shipping... GENERAL PROVISIONS Commercial Diving Operations Equipment § 197.310 Air compressor system. A compressor used to supply breathing air to a diver must have— (a) A volume tank that is— (1) Built and stamped in...

46 CFR 197.310 - Air compressor system.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Air compressor system. 197.310 Section 197.310 Shipping... GENERAL PROVISIONS Commercial Diving Operations Equipment § 197.310 Air compressor system. A compressor used to supply breathing air to a diver must have— (a) A volume tank that is— (1) Built and stamped in...

MicroRNA 203 Modulates Glioma Cell Migration via Robo1/ERK/MMP-9 Signaling

PubMed Central

Dontula, Ranadheer; Dinasarapu, Ashok; Chetty, Chandramu; Pannuru, Padmavathi; Herbert, Engelhard; Ozer, Howard

2013-01-01

Glioblastoma (GBM) is the most common and malignant primary adult brain cancer. Allelic deletion on chromosome 14q plays an important role in the pathogenesis of GBM, and this site was thought to harbor multiple tumor suppressor genes associated with GBM, a region that also encodes microRNA-203 (miR-203). In this study, we sought to identify the role of miR-203 as a tumor suppressor in the pathogenesis of GBM. We analyzed the miR-203 expression data of GBM patients in 10 normal and 495 tumor tissue samples derived from The Cancer Genome Atlas data set. Quantitative real-time PCR and in situ hybridization in 10 high-grade GBM and 10 low-grade anaplastic astrocytoma tumor samples showed decreased levels of miR-203 expression in anaplastic astrocytoma and GBM tissues and cell lines. Exogenous expression of miR-203 using a plasmid expressing miR-203 precursor (pmiR-203) suppressed glioma cell proliferation, migration, and invasion. We determined that one relevant target of miR-203 was Robo1, given that miR-203 expression decreased mRNA and protein levels as determined by RT-PCR and Western blot analysis. Moreover, cotransfection experiments using a luciferase-based transcription reporter assay have shown direct regulation of Robo1 by miR-203. We also show that Robo1 mediates miR-203 mediated antimigratory functions as up-regulation of Robo1 abrogates miR-203 mediated antimigratory effects. We also show that miR-203 expression suppressed ERK phosphorylation and MMP-9 expression in glioma cells. Furthermore, we demonstrate that miR-203 inhibits migration of the glioma cells by disrupting the Robo1/ERK/MMP-9 signaling axis. Taken together, these studies demonstrate that up-regulation of Robo1 in response to the decrease in miR-203 in glioma cells is responsible for glioma tumor cell migration and invasion. PMID:24167656

40 CFR 1065.703 - Distillate diesel fuel.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 1 Cetane Number 40-50 40-50 40-50 ASTM D613-05. Distillation range: Initial boiling point °C 171-204 171-204 171-204 ASTM D86-07a. 10 pct. point 204-238 204-238 204-238 50 pct. point 243-282 243-282 243...-37 ASTM D4052-96e01. Total sulfur, ultra low sulfur mg/kg 7-15 See 40 CFR 80.580. Total sulfur, low...

21 CFR 1305.19 - Cancellation and voiding of DEA Forms 222.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 9 2011-04-01 2011-04-01 false Cancellation and voiding of DEA Forms 222. 1305.19... I AND II CONTROLLED SUBSTANCES DEA Form 222 § 1305.19 Cancellation and voiding of DEA Forms 222. (a) A purchaser may cancel part or all of an order on a DEA Form 222 by notifying the supplier in...

21 CFR 1305.14 - Procedure for endorsing DEA Forms 222.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 9 2011-04-01 2011-04-01 false Procedure for endorsing DEA Forms 222. 1305.14... I AND II CONTROLLED SUBSTANCES DEA Form 222 § 1305.14 Procedure for endorsing DEA Forms 222. (a) A DEA Form 222, made out to any supplier who cannot fill all or a part of the order within the time...

21 CFR 1305.19 - Cancellation and voiding of DEA Forms 222.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Cancellation and voiding of DEA Forms 222. 1305.19... I AND II CONTROLLED SUBSTANCES DEA Form 222 § 1305.19 Cancellation and voiding of DEA Forms 222. (a) A purchaser may cancel part or all of an order on a DEA Form 222 by notifying the supplier in...

Radon survey and soil gamma doses in primary schools of Batman, Turkey.

PubMed

Damla, Nevzat; Aldemir, Kamuran

2014-06-01

A survey was conducted to evaluate levels of indoor radon and gamma doses in 42 primary schools located in Batman, southeastern Anatolia, Turkey. Indoor radon measurements were carried out using CR-39 solid-state nuclear track detector-based radon dosimeters. The overall mean annual (222)Rn activity in the surveyed area was found to be 49 Bq m(-3) (equivalent to an annual effective dose of 0.25 mSv). However, in one of the districts (Besiri) the maximum radon value turned out to be 307 Bq m(-3). The estimated annual effective doses are less than the recommended action level (3-10 mSv). It is found that the radon concentration decreases with increasing floor number. The concentrations of natural and artificial radioisotopes were determined using gamma-ray spectroscopy for soil samples collected in close vicinity of the studied schools. The mean gamma activity concentrations in the soil samples were 31, 25, 329 and 12 Bq kg(-1) for (226)Ra, (232)Th, (40)K and (137)Cs, respectively. The radiological parameters such as the absorbed dose rate in air and the annual effective dose equivalent were calculated. These radiological parameters were evaluated and compared with the internationally recommended values.

42 CFR 488.310 - Extended survey.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 5 2014-10-01 2014-10-01 false Extended survey. 488.310 Section 488.310 Public...) STANDARDS AND CERTIFICATION SURVEY, CERTIFICATION, AND ENFORCEMENT PROCEDURES Survey and Certification of Long-Term Care Facilities § 488.310 Extended survey. (a) Purpose of survey. The purpose of an extended...

42 CFR 488.310 - Extended survey.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Extended survey. 488.310 Section 488.310 Public...) STANDARDS AND CERTIFICATION SURVEY, CERTIFICATION, AND ENFORCEMENT PROCEDURES Survey and Certification of Long-Term Care Facilities § 488.310 Extended survey. (a) Purpose of survey. The purpose of an extended...

42 CFR 488.310 - Extended survey.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 5 2013-10-01 2013-10-01 false Extended survey. 488.310 Section 488.310 Public...) STANDARDS AND CERTIFICATION SURVEY, CERTIFICATION, AND ENFORCEMENT PROCEDURES Survey and Certification of Long-Term Care Facilities § 488.310 Extended survey. (a) Purpose of survey. The purpose of an extended...

42 CFR 488.310 - Extended survey.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 5 2012-10-01 2012-10-01 false Extended survey. 488.310 Section 488.310 Public...) STANDARDS AND CERTIFICATION SURVEY, CERTIFICATION, AND ENFORCEMENT PROCEDURES Survey and Certification of Long-Term Care Facilities § 488.310 Extended survey. (a) Purpose of survey. The purpose of an extended...

42 CFR 488.310 - Extended survey.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Extended survey. 488.310 Section 488.310 Public...) STANDARDS AND CERTIFICATION SURVEY, CERTIFICATION, AND ENFORCEMENT PROCEDURES Survey and Certification of Long-Term Care Facilities § 488.310 Extended survey. (a) Purpose of survey. The purpose of an extended...

12 CFR 3.10 - Minimum capital requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Minimum capital requirements. 3.10 Section 3.10 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY CAPITAL ADEQUACY STANDARDS Capital Ratio Requirements and Buffers § 3.10 Minimum capital requirements. (a) Minimum capital...

31 CFR 585.310 - Entity.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Entity. 585.310 Section 585.310 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS... Definitions § 585.310 Entity. The term entity includes a corporation, partnership, association, or other...

32 CFR 310.25 - Disclosure accounting.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 2 2013-07-01 2013-07-01 false Disclosure accounting. 310.25 Section 310.25... PROGRAM DOD PRIVACY PROGRAM Disclosure of Personal Information to Other Agencies and Third Parties § 310.25 Disclosure accounting. (a) Disclosure accountings. (1) Keep an accurate record of all disclosures...

32 CFR 310.25 - Disclosure accounting.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false Disclosure accounting. 310.25 Section 310.25... PROGRAM DOD PRIVACY PROGRAM Disclosure of Personal Information to Other Agencies and Third Parties § 310.25 Disclosure accounting. (a) Disclosure accountings. (1) Keep an accurate record of all disclosures...

32 CFR 310.25 - Disclosure accounting.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 2 2012-07-01 2012-07-01 false Disclosure accounting. 310.25 Section 310.25... PROGRAM DOD PRIVACY PROGRAM Disclosure of Personal Information to Other Agencies and Third Parties § 310.25 Disclosure accounting. (a) Disclosure accountings. (1) Keep an accurate record of all disclosures...

32 CFR 310.25 - Disclosure accounting.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 2 2011-07-01 2011-07-01 false Disclosure accounting. 310.25 Section 310.25... PROGRAM DOD PRIVACY PROGRAM Disclosure of Personal Information to Other Agencies and Third Parties § 310.25 Disclosure accounting. (a) Disclosure accountings. (1) Keep an accurate record of all disclosures...

The influence of chronic conditions and the environment on pubertal development. An example from medieval England.

PubMed

Lewis, M E; Shapland, F; Watts, R

2016-03-01

Adolescence is a unique period in human development encompassing sexual maturation (puberty) and the physical and psychological transition into adulthood. It is a crucial time for healthy development and any adverse environmental conditions, poor nutrition, or chronic infection can alter the timing of these physical changes; delaying menarche in girls or the age of peak height velocity in boys. This study explores the impact of chronic illness on the tempo of puberty in 607 adolescent skeletons from medieval England (AD 900-1550). A total of 135 (22.2%) adolescents showed some delay in their pubertal development, and this lag increased with age. Of those with a chronic condition, 40.0% (n=24/60) showed delay compared to only 20.3% (n=111/547) of the non-pathology group. This difference was statistically significant. A binary logistic regression model demonstrated a significant association between increasing delay in pubertal stage attainment with age in the pathology group. This is the first time that chronic conditions have been directly associated with a delay in maturation in the osteological record, using a new method to assess stages of puberty in skeletal remains. Copyright © 2015 Elsevier Inc. All rights reserved.

17 CFR 204.34 - Employee response.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Employee response. 204.34... DEBT COLLECTION Salary Offset § 204.34 Employee response. (a) Introduction. An employee must respond to... ways discussed in § 204.34, Employee response, and § 204.35, Petition for pre-offset hearing. Where...

Statistical analysis of the radon-222 potential of rocks in Virginia, U.S.A.

USGS Publications Warehouse

Brown, C. Erwin; Mose, D.G.; Mushrush, G.W.; Chrosniak, C.E.

1992-01-01

More than 3,200 indoor radon-222 (222Rn) measurements were made seasonally in an area of about 1,000 square kilometers of the Coastal Plain and Piedmont physiographic provinces in Virginia, U.S.A. Results of these measurements indicate that some geological units are associated, on the average, with twice as much indoor222Rn as other geological units, and that indoor222Rn varies seasonally. The Kruskal-Wallis test was used to test whether indoor222Rn concentrations for data gathered over the winter and summer seasons differ significantly by rock unit. The tests concluded that indoor222Rn concentrations for different rock units were not equal at the 5-percent significance level. The rocks associated with the highest median indoor222Rn concentration are specific rocks in the Mesozoic Culpeper basin, including shale and siltstone units with Jurassic diabase intrusives, and mica schists in the Piedmont physiographic province. The pre-Triassic Peters Creek Schist has the highest ranking in terms of indoor222Rn concentration. The rocks associated with the lowest indoor222Rn concentrations include coastal plain sediments, the Occoquan Granite, Falls Church Tonalite, Piney Branch Mafic and Ultramafic complex, and unnamed mafic and ultramafic inclusions, respectively. The rocks have been ranked according to observed222Rn concentration by transforming the average rank of indoor222Rn concentrations to z scores. ?? 1992 Springer-Verlag New York Inc.

Lower Wingate Test Power Outcomes From "All-Out" Pretest Pedaling Cadence Compared With Moderate Cadence.

PubMed

Lunn, William R; Zenoni, Maria A; Crandall, Ian H; Dress, Ashley E; Berglund, Michelle L

2015-08-01

The aim of the present study was to determine the effect of different pretest pedaling cadences on power outcomes obtained during the Wingate Anaerobic Test (WAnT). Vigorously exercising adult men (n = 14, 24.9 ± 1.2 years) and women (n = 14, 20.4 ± 0.6 years) participated in a randomized crossover study during which they performed the 30-second WAnT on a mechanically braked cycle ergometer (0.075 kg·kg(-1) body weight) under 2 conditions. Participants pedaled maximally with an unloaded flywheel during 5 seconds before resistance was applied and the test began (FAST). In another trial, participants maintained a moderate cadence (80 revolutions per minute [rpm]) during 5 seconds before the test began (MOD). All other components of the WAnT were identical. Peak power (PP), mean power (MP), minimum power (MinP), fatigue index (%FAT), and maximum cadence during test were recorded. Comparisons were made using a 2 × 2 factorial repeated-measures analysis of variance. Regardless of gender, the FAST condition resulted in 22.2% lower PP (612.6 ± 33.0 W vs. 788.3 ± 43.5 W), 13.3% lower MP (448.4 ± 22.2 W vs. 517.2 ± 26.4 W), 11.7% lower MinP (280.9 ± 14.8 W vs. 318.3 ± 17.2 W), and 9.0% lower %FAT (53.5 ± 1.3% vs. 58.8 ± 1.5%) than MOD condition (p < 0.01; mean ± SD). Similar outcomes were observed within gender. The authors conclude that practitioners of the WAnT should instruct participants to maintain a moderate pedal cadence (∼80 rpm) during 5 seconds before the test commences to avoid bias from software sampling and peripheral fatigue. Standardizing the pretest pedal cadence will be important to exercise testing professionals who compare data with norms or generate norms for specific populations.

Tuberculosis transmission in the Indigenous peoples of the Canadian prairies

PubMed Central

Patel, Smit; Paulsen, Catherine; Heffernan, Courtney; Saunders, Duncan; Sharma, Meenu; King, Malcolm; Hoeppner, Vernon; Orr, Pamela; Kunimoto, Dennis; Menzies, Dick; Christianson, Sara; Wolfe, Joyce; Boffa, Jody; McMullin, Kathleen; Lopez-Hille, Carmen; Senthilselvan, Ambikaipakan

2017-01-01

Setting The prairie provinces of Canada. Objective To characterize tuberculosis (TB) transmission among the Indigenous and non-Indigenous Canadian-born peoples of the prairie provinces of Canada. Design A prospective epidemiologic study of consecutively diagnosed adult (age ≥ 14 years) Canadian-born culture-positive pulmonary TB cases on the prairies, hereafter termed “potential transmitters,” and the transmission events generated by them. “Transmission events” included new positive tuberculin skin tests (TSTs), TST conversions, and secondary cases among contacts. Results In the years 2007 and 2008, 222 potential transmitters were diagnosed on the prairies. Of these, the vast majority (198; 89.2%) were Indigenous peoples who resided in either an Indigenous community (135; 68.2%) or a major metropolitan area (44; 22.2%). Over the 4.5-year period between July 1st, 2006 and December 31st 2010, 1085 transmission events occurred in connection with these potential transmitters. Most of these transmission events were attributable to potential transmitters who identified as Indigenous (94.5%). With a few notable exceptions most transmitters and their infected contacts resided in the same community type. In multivariate models positive smear status and a higher number of close contacts were associated with increased transmission; adjusted odds ratios (ORs) and 95% confidence intervals (CIs), 4.30 [1.88, 9.84] and 2.88 [1.31, 6.34], respectively. Among infected contacts, being Indigenous was associated with disease progression; OR and 95% CI, 3.59 [1.27, 10.14] and 6.89 [2.04, 23.25] depending upon Indigenous group, while being an infected casual contact was less likely than being a close contact to be associated with disease progression, 0.66 [0.44, 1.00]. Conclusion In the prairie provinces of Canada and among Canadian-born persons, Indigenous peoples account for the vast majority of cases with the potential to transmit as well as the vast majority of infected contacts. Active case finding and preventative therapy measures need to focus on high-incidence Indigenous communities. PMID:29136652

Tuberculosis transmission in the Indigenous peoples of the Canadian prairies.

PubMed

Patel, Smit; Paulsen, Catherine; Heffernan, Courtney; Saunders, Duncan; Sharma, Meenu; King, Malcolm; Hoeppner, Vernon; Orr, Pamela; Kunimoto, Dennis; Menzies, Dick; Christianson, Sara; Wolfe, Joyce; Boffa, Jody; McMullin, Kathleen; Lopez-Hille, Carmen; Senthilselvan, Ambikaipakan; Long, Richard

2017-01-01

The prairie provinces of Canada. To characterize tuberculosis (TB) transmission among the Indigenous and non-Indigenous Canadian-born peoples of the prairie provinces of Canada. A prospective epidemiologic study of consecutively diagnosed adult (age ≥ 14 years) Canadian-born culture-positive pulmonary TB cases on the prairies, hereafter termed "potential transmitters," and the transmission events generated by them. "Transmission events" included new positive tuberculin skin tests (TSTs), TST conversions, and secondary cases among contacts. In the years 2007 and 2008, 222 potential transmitters were diagnosed on the prairies. Of these, the vast majority (198; 89.2%) were Indigenous peoples who resided in either an Indigenous community (135; 68.2%) or a major metropolitan area (44; 22.2%). Over the 4.5-year period between July 1st, 2006 and December 31st 2010, 1085 transmission events occurred in connection with these potential transmitters. Most of these transmission events were attributable to potential transmitters who identified as Indigenous (94.5%). With a few notable exceptions most transmitters and their infected contacts resided in the same community type. In multivariate models positive smear status and a higher number of close contacts were associated with increased transmission; adjusted odds ratios (ORs) and 95% confidence intervals (CIs), 4.30 [1.88, 9.84] and 2.88 [1.31, 6.34], respectively. Among infected contacts, being Indigenous was associated with disease progression; OR and 95% CI, 3.59 [1.27, 10.14] and 6.89 [2.04, 23.25] depending upon Indigenous group, while being an infected casual contact was less likely than being a close contact to be associated with disease progression, 0.66 [0.44, 1.00]. In the prairie provinces of Canada and among Canadian-born persons, Indigenous peoples account for the vast majority of cases with the potential to transmit as well as the vast majority of infected contacts. Active case finding and preventative therapy measures need to focus on high-incidence Indigenous communities.

75 FR 57880 - Airworthiness Directives; Airbus Model A310 Series Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-23

... docket. Relevant Service Information Airbus has issued Mandatory Service Bulletin A310-27-2099, Revision... Service Bulletin A310-27-2099, dated February 17, 2006; or Airbus Mandatory Service Bulletin A310-27-2099...- 2099, Revision 01, dated March 21, 2008. Note 1: For the purposes of this AD, a detailed inspection is...

20 CFR 416.310 - What makes an application a claim for benefits.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false What makes an application a claim for benefits. 416.310 Section 416.310 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Filing of Applications Applications § 416.310 What makes an...

20 CFR 416.310 - What makes an application a claim for benefits.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false What makes an application a claim for benefits. 416.310 Section 416.310 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Filing of Applications Applications § 416.310 What makes an...

20 CFR 416.310 - What makes an application a claim for benefits.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false What makes an application a claim for benefits. 416.310 Section 416.310 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Filing of Applications Applications § 416.310 What makes an...

20 CFR 416.310 - What makes an application a claim for benefits.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false What makes an application a claim for benefits. 416.310 Section 416.310 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Filing of Applications Applications § 416.310 What makes an...

20 CFR 416.310 - What makes an application a claim for benefits.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false What makes an application a claim for benefits. 416.310 Section 416.310 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Filing of Applications Applications § 416.310 What makes an...

49 CFR 195.310 - Records.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 3 2010-10-01 2010-10-01 false Records. 195.310 Section 195.310 Transportation... PIPELINE Pressure Testing § 195.310 Records. (a) A record must be made of each pressure test required by this subpart, and the record of the latest test must be retained as long as the facility tested is in...

49 CFR 195.310 - Records.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 3 2013-10-01 2013-10-01 false Records. 195.310 Section 195.310 Transportation... PIPELINE Pressure Testing § 195.310 Records. (a) A record must be made of each pressure test required by this subpart, and the record of the latest test must be retained as long as the facility tested is in...

49 CFR 195.310 - Records.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 3 2012-10-01 2012-10-01 false Records. 195.310 Section 195.310 Transportation... PIPELINE Pressure Testing § 195.310 Records. (a) A record must be made of each pressure test required by this subpart, and the record of the latest test must be retained as long as the facility tested is in...

12 CFR 1102.310 - Service of process.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Service of process. 1102.310 Section 1102.310... Office, Procedures, Public Information § 1102.310 Service of process. (a) Service. Any subpoena or other... 20006. Where the ASC is named as a party, service of process shall be made pursuant to the Federal Rules...

21 CFR 1305.14 - Procedure for endorsing DEA Forms 222.

Code of Federal Regulations, 2010 CFR

2010-04-01

... on the reverse sides of Copies 1 and 2 of the DEA Form 222) the name and address of the second... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Procedure for endorsing DEA Forms 222. 1305.14... I AND II CONTROLLED SUBSTANCES DEA Form 222 § 1305.14 Procedure for endorsing DEA Forms 222. (a) A...

21 CFR 1305.16 - Lost and stolen DEA Forms 222.

Code of Federal Regulations, 2010 CFR

2010-04-01

... names and addresses of the purchasers. (d) If an entire book of DEA Forms 222 is lost or stolen, and the... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Lost and stolen DEA Forms 222. 1305.16 Section... II CONTROLLED SUBSTANCES DEA Form 222 § 1305.16 Lost and stolen DEA Forms 222. (a) If a purchaser...

21 CFR 1305.15 - Unaccepted and defective DEA Forms 222.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 9 2011-04-01 2011-04-01 false Unaccepted and defective DEA Forms 222. 1305.15... I AND II CONTROLLED SUBSTANCES DEA Form 222 § 1305.15 Unaccepted and defective DEA Forms 222. (a) A DEA Form 222 must not be filled if either of the following apply: (1) The order is not complete...

21 CFR 1305.16 - Lost and stolen DEA Forms 222.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 9 2011-04-01 2011-04-01 false Lost and stolen DEA Forms 222. 1305.16 Section... II CONTROLLED SUBSTANCES DEA Form 222 § 1305.16 Lost and stolen DEA Forms 222. (a) If a purchaser ascertains that an unfilled DEA Form 222 has been lost, he or she must execute another in triplicate and...

21 CFR 1305.15 - Unaccepted and defective DEA Forms 222.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Unaccepted and defective DEA Forms 222. 1305.15... I AND II CONTROLLED SUBSTANCES DEA Form 222 § 1305.15 Unaccepted and defective DEA Forms 222. (a) A DEA Form 222 must not be filled if either of the following apply: (1) The order is not complete...

44 CFR 204.27-204.40 - [Reserved

Code of Federal Regulations, 2014 CFR

2014-10-01

... 44 Emergency Management and Assistance 1 2014-10-01 2014-10-01 false [Reserved] 204.27-204.40 Section 204.27-204.40 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FIRE MANAGEMENT ASSISTANCE GRANT PROGRAM Declaration Process...

44 CFR 204.27-204.40 - [Reserved

Code of Federal Regulations, 2012 CFR

2012-10-01

... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true [Reserved] 204.27-204.40 Section 204.27-204.40 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FIRE MANAGEMENT ASSISTANCE GRANT PROGRAM Declaration Process...

44 CFR 204.27-204.40 - [Reserved

Code of Federal Regulations, 2013 CFR

2013-10-01

... 44 Emergency Management and Assistance 1 2013-10-01 2013-10-01 false [Reserved] 204.27-204.40 Section 204.27-204.40 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FIRE MANAGEMENT ASSISTANCE GRANT PROGRAM Declaration Process...

44 CFR 204.27-204.40 - [Reserved

Code of Federal Regulations, 2011 CFR

2011-10-01

... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false [Reserved] 204.27-204.40 Section 204.27-204.40 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FIRE MANAGEMENT ASSISTANCE GRANT PROGRAM Declaration Process...

44 CFR 204.27-204.40 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false [Reserved] 204.27-204.40 Section 204.27-204.40 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FIRE MANAGEMENT ASSISTANCE GRANT PROGRAM Declaration Process...

12 CFR 310.3 - Procedures for requests pertaining to individual records in a system of records.

Code of Federal Regulations, 2010 CFR

2010-01-01

... individual records in a system of records. 310.3 Section 310.3 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE PRIVACY ACT REGULATIONS § 310.3 Procedures for requests pertaining to individual records in a system of records. (a) Any present or former employee of the Corporation...

12 CFR 310.3 - Procedures for requests pertaining to individual records in a system of records.

Code of Federal Regulations, 2011 CFR

2011-01-01

... individual records in a system of records. 310.3 Section 310.3 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE PRIVACY ACT REGULATIONS § 310.3 Procedures for requests pertaining to individual records in a system of records. (a) Any present or former employee of the Corporation...

12 CFR 310.3 - Procedures for requests pertaining to individual records in a system of records.

Code of Federal Regulations, 2014 CFR

2014-01-01

... individual records in a system of records. 310.3 Section 310.3 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE PRIVACY ACT REGULATIONS § 310.3 Procedures for requests pertaining to individual records in a system of records. (a) Any present or former employee of the Corporation...

12 CFR 310.3 - Procedures for requests pertaining to individual records in a system of records.

Code of Federal Regulations, 2013 CFR

2013-01-01

... individual records in a system of records. 310.3 Section 310.3 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE PRIVACY ACT REGULATIONS § 310.3 Procedures for requests pertaining to individual records in a system of records. (a) Any present or former employee of the Corporation...

12 CFR 310.3 - Procedures for requests pertaining to individual records in a system of records.

Code of Federal Regulations, 2012 CFR

2012-01-01

... individual records in a system of records. 310.3 Section 310.3 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE PRIVACY ACT REGULATIONS § 310.3 Procedures for requests pertaining to individual records in a system of records. (a) Any present or former employee of the Corporation...

7 CFR 1940.310 - Categorical exclusions from National Environmental Policy Act (NEPA) reviews.

Code of Federal Regulations, 2012 CFR

2012-01-01

... prime forestlands or rangelands, (4) A listed species or critical habitat for an endangered species, (5... Policy Act (NEPA) reviews. 1940.310 Section 1940.310 Agriculture Regulations of the Department of... Environmental Program § 1940.310 Categorical exclusions from National Environmental Policy Act (NEPA) reviews...

46 CFR 310.65 - Graduation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 8 2014-10-01 2014-10-01 false Graduation. 310.65 Section 310.65 Shipping MARITIME... Midshipmen at the United States Merchant Marine Academy § 310.65 Graduation. (a) Classes enrolled prior to... agreement to serve in one of the following categories immediately after graduation: (i) Sail on his or her...

46 CFR 310.65 - Graduation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 8 2013-10-01 2013-10-01 false Graduation. 310.65 Section 310.65 Shipping MARITIME... Midshipmen at the United States Merchant Marine Academy § 310.65 Graduation. (a) Classes enrolled prior to... agreement to serve in one of the following categories immediately after graduation: (i) Sail on his or her...

46 CFR 310.65 - Graduation.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 8 2012-10-01 2012-10-01 false Graduation. 310.65 Section 310.65 Shipping MARITIME... Midshipmen at the United States Merchant Marine Academy § 310.65 Graduation. (a) Classes enrolled prior to... agreement to serve in one of the following categories immediately after graduation: (i) Sail on his or her...

32 CFR 310.20 - Reproduction fees.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 2 2011-07-01 2011-07-01 false Reproduction fees. 310.20 Section 310.20... PROGRAM DOD PRIVACY PROGRAM Access by Individuals § 310.20 Reproduction fees. (a) Assessing fees. (1) Charge the individual only the direct cost of reproduction. (2) Do not charge reproduction fees if...

32 CFR 310.20 - Reproduction fees.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Reproduction fees. 310.20 Section 310.20... PROGRAM DOD PRIVACY PROGRAM Access by Individuals § 310.20 Reproduction fees. (a) Assessing fees. (1) Charge the individual only the direct cost of reproduction. (2) Do not charge reproduction fees if...

33 CFR 334.310 - Chesapeake Bay, Lynnhaven Roads; navy amphibious training area.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Chesapeake Bay, Lynnhaven Roads; navy amphibious training area. 334.310 Section 334.310 Navigation and Navigable Waters CORPS OF....310 Chesapeake Bay, Lynnhaven Roads; navy amphibious training area. (a) The restricted area. Beginning...

46 CFR 183.310 - Power sources.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Power sources. 183.310 Section 183.310 Shipping COAST...) ELECTRICAL INSTALLATION Power Sources and Distribution Systems § 183.310 Power sources. (a)(1) Each vessel that relies on electricity to power the following loads must be arranged so that the loads can be...

46 CFR 120.310 - Power sources.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Power sources. 120.310 Section 120.310 Shipping COAST... PASSENGERS OR WITH OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS ELECTRICAL INSTALLATION Power Sources and Distribution Systems § 120.310 Power sources. (a)(1) Each vessel that relies on electricity to...

46 CFR 183.310 - Power sources.

Code of Federal Regulations, 2013 CFR

2013-10-01

...) ELECTRICAL INSTALLATION Power Sources and Distribution Systems § 183.310 Power sources. (a)(1) Each vessel that relies on electricity to power the following loads must be arranged so that the loads can be... 46 Shipping 7 2013-10-01 2013-10-01 false Power sources. 183.310 Section 183.310 Shipping COAST...

46 CFR 183.310 - Power sources.

Code of Federal Regulations, 2012 CFR

2012-10-01

...) ELECTRICAL INSTALLATION Power Sources and Distribution Systems § 183.310 Power sources. (a)(1) Each vessel that relies on electricity to power the following loads must be arranged so that the loads can be... 46 Shipping 7 2012-10-01 2012-10-01 false Power sources. 183.310 Section 183.310 Shipping COAST...

46 CFR 183.310 - Power sources.

Code of Federal Regulations, 2014 CFR

2014-10-01

...) ELECTRICAL INSTALLATION Power Sources and Distribution Systems § 183.310 Power sources. (a)(1) Each vessel that relies on electricity to power the following loads must be arranged so that the loads can be... 46 Shipping 7 2014-10-01 2014-10-01 false Power sources. 183.310 Section 183.310 Shipping COAST...

46 CFR 183.310 - Power sources.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) ELECTRICAL INSTALLATION Power Sources and Distribution Systems § 183.310 Power sources. (a)(1) Each vessel that relies on electricity to power the following loads must be arranged so that the loads can be... 46 Shipping 7 2011-10-01 2011-10-01 false Power sources. 183.310 Section 183.310 Shipping COAST...

46 CFR 120.310 - Power sources.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 4 2011-10-01 2011-10-01 false Power sources. 120.310 Section 120.310 Shipping COAST... PASSENGERS OR WITH OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS ELECTRICAL INSTALLATION Power Sources and Distribution Systems § 120.310 Power sources. (a)(1) Each vessel that relies on electricity to...

40 CFR 310.24 - What happens if I provide incorrect or false information?

Code of Federal Regulations, 2010 CFR

2010-07-01

... false information? 310.24 Section 310.24 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... § 310.24 What happens if I provide incorrect or false information? (a) You must not knowingly or recklessly make any statement or provide any information in your reimbursement application that is false...

42 CFR 457.310 - Targeted low-income child.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 4 2013-10-01 2013-10-01 false Targeted low-income child. 457.310 Section 457.310... (CONTINUED) STATE CHILDREN'S HEALTH INSURANCE PROGRAMS (SCHIPs) ALLOTMENTS AND GRANTS TO STATES State Plan Requirements: Eligibility, Screening, Applications, and Enrollment § 457.310 Targeted low-income child. (a...

42 CFR 457.310 - Targeted low-income child.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 4 2012-10-01 2012-10-01 false Targeted low-income child. 457.310 Section 457.310... (CONTINUED) STATE CHILDREN'S HEALTH INSURANCE PROGRAMS (SCHIPs) ALLOTMENTS AND GRANTS TO STATES State Plan Requirements: Eligibility, Screening, Applications, and Enrollment § 457.310 Targeted low-income child. (a...

42 CFR 457.310 - Targeted low-income child.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 4 2011-10-01 2011-10-01 false Targeted low-income child. 457.310 Section 457.310... (CONTINUED) STATE CHILDREN'S HEALTH INSURANCE PROGRAMS (SCHIPs) ALLOTMENTS AND GRANTS TO STATES State Plan Requirements: Eligibility, Screening, Applications, and Enrollment § 457.310 Targeted low-income child. (a...

42 CFR 457.310 - Targeted low-income child.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 4 2014-10-01 2014-10-01 false Targeted low-income child. 457.310 Section 457.310... (CONTINUED) STATE CHILDREN'S HEALTH INSURANCE PROGRAMS (SCHIPs) ALLOTMENTS AND GRANTS TO STATES State Plan Requirements: Eligibility, Screening, Applications, and Enrollment § 457.310 Targeted low-income child. (a...

42 CFR 457.310 - Targeted low-income child.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 4 2010-10-01 2010-10-01 false Targeted low-income child. 457.310 Section 457.310... (CONTINUED) STATE CHILDREN'S HEALTH INSURANCE PROGRAMS (SCHIPs) ALLOTMENTS AND GRANTS TO STATES State Plan Requirements: Eligibility, Screening, Applications, and Enrollment § 457.310 Targeted low-income child. (a...

45 CFR 164.310 - Physical safeguards.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 1 2013-10-01 2013-10-01 false Physical safeguards. 164.310 Section 164.310... Information § 164.310 Physical safeguards. A covered entity or business associate must, in accordance with... physical access to its electronic information systems and the facility or facilities in which they are...

45 CFR 164.310 - Physical safeguards.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 1 2014-10-01 2014-10-01 false Physical safeguards. 164.310 Section 164.310... Information § 164.310 Physical safeguards. A covered entity or business associate must, in accordance with... physical access to its electronic information systems and the facility or facilities in which they are...

30 CFR 77.310 - Control panels.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Control panels. 77.310 Section 77.310 Mineral....310 Control panels. (a) All thermal dryer system control panels constructed after June 30, 1971 shall... each thermocouple, pressure tap, or other control or gaging instrument in the drying system shall be...

30 CFR 77.310 - Control panels.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Control panels. 77.310 Section 77.310 Mineral....310 Control panels. (a) All thermal dryer system control panels constructed after June 30, 1971 shall... each thermocouple, pressure tap, or other control or gaging instrument in the drying system shall be...

30 CFR 77.310 - Control panels.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Control panels. 77.310 Section 77.310 Mineral....310 Control panels. (a) All thermal dryer system control panels constructed after June 30, 1971 shall... each thermocouple, pressure tap, or other control or gaging instrument in the drying system shall be...

22 CFR 3.10 - Enforcement.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Enforcement. 3.10 Section 3.10 Foreign Relations DEPARTMENT OF STATE GENERAL GIFTS AND DECORATIONS FROM FOREIGN GOVERNMENTS § 3.10 Enforcement. (a) Each employing agency is responsible under the Act for reporting to the Attorney General cases in which...

32 CFR 310.36 - OMB training guidelines.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false OMB training guidelines. 310.36 Section 310.36... PROGRAM DOD PRIVACY PROGRAM Training Requirements § 310.36 OMB training guidelines. The OMB guidelines (OMB Privacy Guidelines, 40 FR 28948 (July 9, 1975) require all agencies additionally to: (a) Instruct...

42 CFR 425.310 - Marketing requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 3 2014-10-01 2014-10-01 false Marketing requirements. 425.310 Section 425.310... Protections § 425.310 Marketing requirements. (a) File and use. Marketing materials and activities, as defined...) The ACO certifies compliance with all the marketing requirements under this section; and (2) CMS does...

42 CFR 425.310 - Marketing requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 3 2013-10-01 2013-10-01 false Marketing requirements. 425.310 Section 425.310... Protections § 425.310 Marketing requirements. (a) File and use. Marketing materials and activities, as defined...) The ACO certifies compliance with all the marketing requirements under this section; and (2) CMS does...

42 CFR 425.310 - Marketing requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 3 2012-10-01 2012-10-01 false Marketing requirements. 425.310 Section 425.310... Protections § 425.310 Marketing requirements. (a) File and use. Marketing materials and activities, as defined...) The ACO certifies compliance with all the marketing requirements under this section; and (2) CMS does...

32 CFR 310.46 - Civil actions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false Civil actions. 310.46 Section 310.46 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM DOD PRIVACY PROGRAM Privacy Act Violations § 310.46 Civil actions. An individual may file a civil suit...

32 CFR 310.46 - Civil actions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 2 2012-07-01 2012-07-01 false Civil actions. 310.46 Section 310.46 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM DOD PRIVACY PROGRAM Privacy Act Violations § 310.46 Civil actions. An individual may file a civil suit...

32 CFR 310.46 - Civil actions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 2 2013-07-01 2013-07-01 false Civil actions. 310.46 Section 310.46 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM DOD PRIVACY PROGRAM Privacy Act Violations § 310.46 Civil actions. An individual may file a civil suit...

32 CFR 310.46 - Civil actions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Civil actions. 310.46 Section 310.46 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM DOD PRIVACY PROGRAM Privacy Act Violations § 310.46 Civil actions. An individual may file a civil suit...

32 CFR 310.46 - Civil actions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 2 2011-07-01 2011-07-01 false Civil actions. 310.46 Section 310.46 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM DOD PRIVACY PROGRAM Privacy Act Violations § 310.46 Civil actions. An individual may file a civil suit...

46 CFR 310.3 - Schools and courses.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 8 2011-10-01 2011-10-01 false Schools and courses. 310.3 Section 310.3 Shipping... Minimum Standards for State, Territorial or Regional Maritime Academies and Colleges § 310.3 Schools and courses. (a) Schools with Federal aid. The following schools are presently operating with Federal aid...

Bioinspired Cocatalysts Decorated WO3 Nanotube Toward Unparalleled Hydrogen Sulfide Chemiresistor.

PubMed

Kim, Dong-Ha; Jang, Ji-Soo; Koo, Won-Tae; Choi, Seon-Jin; Cho, Hee-Jin; Kim, Min-Hyeok; Kim, Sang-Joon; Kim, Il-Doo

2018-06-22

Herein, we incorporated dual biotemplates, i.e., cellulose nanocrystals (CNC) and apoferritin, into electrospinning solution to achieve three distinct benefits, i.e., (i) facile synthesis of a WO 3 nanotube by utilizing the self-agglomerating nature of CNC in the core of as-spun nanofibers, (ii) effective sensitization by partial phase transition from WO 3 to Na 2 W 4 O 13 induced by interaction between sodium-doped CNC and WO 3 during calcination, and (iii) uniform functionalization with monodispersive apoferritin-derived Pt catalytic nanoparticles (2.22 ± 0.42 nm). Interestingly, the sensitization effect of Na 2 W 4 O 13 on WO 3 resulted in highly selective H 2 S sensing characteristics against seven different interfering molecules. Furthermore, synergistic effects with a bioinspired Pt catalyst induced a remarkably enhanced H 2 S response ( R air / R gas = 203.5), unparalleled selectivity ( R air / R gas < 1.3 for the interfering molecules), and rapid response (<10 s)/recovery (<30 s) time at 1 ppm of H 2 S under 95% relative humidity level. This work paves the way for a new class of cosensitization routes to overcome critical shortcomings of SMO-based chemical sensors, thus providing a potential platform for diagnosis of halitosis.

21 CFR 1305.11 - Procedure for obtaining DEA Forms 222.

Code of Federal Regulations, 2010 CFR

2010-04-01

... the name, address, and registration number of the registrant and the number of books of DEA Forms 222... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Procedure for obtaining DEA Forms 222. 1305.11... I AND II CONTROLLED SUBSTANCES DEA Form 222 § 1305.11 Procedure for obtaining DEA Forms 222. (a) DEA...

21 CFR 1305.17 - Preservation of DEA Forms 222.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 9 2011-04-01 2011-04-01 false Preservation of DEA Forms 222. 1305.17 Section... II CONTROLLED SUBSTANCES DEA Form 222 § 1305.17 Preservation of DEA Forms 222. (a) The purchaser must retain Copy 3 of each executed DEA Form 222 and all copies of unaccepted or defective forms with each...

21 CFR 1305.17 - Preservation of DEA Forms 222.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Preservation of DEA Forms 222. 1305.17 Section... II CONTROLLED SUBSTANCES DEA Form 222 § 1305.17 Preservation of DEA Forms 222. (a) The purchaser must retain Copy 3 of each executed DEA Form 222 and all copies of unaccepted or defective forms with each...

46 CFR 177.310 - Satisfactory service as a design basis.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Satisfactory service as a design basis. 177.310 Section 177.310 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) CONSTRUCTION AND ARRANGEMENT Hull Structure § 177.310 Satisfactory service as a design basis. When scantlings for the hull,...

46 CFR 177.310 - Satisfactory service as a design basis.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Satisfactory service as a design basis. 177.310 Section 177.310 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) CONSTRUCTION AND ARRANGEMENT Hull Structure § 177.310 Satisfactory service as a design basis. When scantlings for the hull,...

46 CFR 177.310 - Satisfactory service as a design basis.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Satisfactory service as a design basis. 177.310 Section 177.310 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) CONSTRUCTION AND ARRANGEMENT Hull Structure § 177.310 Satisfactory service as a design basis. When scantlings for the hull,...

46 CFR 128.310 - Fuel.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Fuel. 128.310 Section 128.310 Shipping COAST GUARD... Main and Auxiliary Machinery § 128.310 Fuel. (a) Except as provided by paragraph (b) of this section..., must be driven by a fuel having a flashpoint of not lower than 43 °C (110 °F) as determined by ASTM D...

46 CFR 128.310 - Fuel.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 4 2014-10-01 2014-10-01 false Fuel. 128.310 Section 128.310 Shipping COAST GUARD... Main and Auxiliary Machinery § 128.310 Fuel. (a) OSVs of less than 6,000 GT ITC (500 GRT if GT ITC is... main propulsion or for auxiliaries, must be driven by a fuel having a flashpoint of not lower than 43...

46 CFR 128.310 - Fuel.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 4 2013-10-01 2013-10-01 false Fuel. 128.310 Section 128.310 Shipping COAST GUARD... Main and Auxiliary Machinery § 128.310 Fuel. (a) Except as provided by paragraph (b) of this section..., must be driven by a fuel having a flashpoint of not lower than 43 °C (110 °F) as determined by ASTM D...

46 CFR 128.310 - Fuel.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 4 2012-10-01 2012-10-01 false Fuel. 128.310 Section 128.310 Shipping COAST GUARD... Main and Auxiliary Machinery § 128.310 Fuel. (a) Except as provided by paragraph (b) of this section..., must be driven by a fuel having a flashpoint of not lower than 43 °C (110 °F) as determined by ASTM D...

46 CFR 128.310 - Fuel.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 4 2011-10-01 2011-10-01 false Fuel. 128.310 Section 128.310 Shipping COAST GUARD... Main and Auxiliary Machinery § 128.310 Fuel. (a) Except as provided by paragraph (b) of this section..., must be driven by a fuel having a flashpoint of not lower than 43 °C (110 °F) as determined by ASTM D...

Use of Tricaine Methanesulfonate (MS222) for Euthanasia of Reptiles

PubMed Central

Conroy, CJ; Papenfuss, T; Parker, J; Hahn, NE

2009-01-01

Tricaine methanesulfonate (MS222) injected into the intracoelomic cavity of reptiles was evaluated as a chemical euthanasia method. Three western fence lizards, 2 desert iguanas, 4 garter snakes, and 6 geckos were euthanized by intracoelomic injection of 250 to 500 mg/kg of 0.7% to 1% sodium-bicarbonate–buffered MS222 solution followed by intracoelomic injection of 0.1 to 1.0 ml unbuffered 50% (v/v) MS222 solution. A simple 2-stage protocol for euthanasia of reptiles by using MS222 is outlined. In addition, the conditions for safe use of MS222 are discussed. MS222 offers an alternative to sodium pentobarbital for euthanasia of reptiles. PMID:19245747

48 CFR 243.204-70-5 - Exceptions.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70-5 Exceptions. (a) The limitations in 243.204-70-2, 243.204-70-3, and 243.204-70-4 do not apply to unpriced change orders... change orders for ship construction and ship repair. (c) The head of the agency may waive the limitations...

48 CFR 243.204-70-5 - Exceptions.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70-5 Exceptions. (a) The limitations in 243.204-70-2, 243.204-70-3, and 243.204-70-4 do not apply to unpriced change orders... change orders for ship construction and ship repair. (c) The head of the agency may waive the limitations...

miR-204 inhibits angiogenesis and promotes sensitivity to cetuximab in head and neck squamous cell carcinoma cells by blocking JAK2-STAT3 signaling.

PubMed

Wu, Qingwei; Zhao, Yingying; Wang, Peihua

2018-03-01

This study aims to investigate the roles of miR-204 in tumor angiogenesis of head and neck squamous cell carcinoma (HNSCC). Here, we found that miR-204 level was reduced in HNSCC tissues relative to that in normal adjacent tissues. Overexpression of miR-204 promoted tumor angiogenesis in HNSCC cells. Mechanistically, JAK2 was identified as a direct target of miR-204, and miR-204 overexpression blocked JAK2/STAT3 pathway. Moreover, overexpression of JAK2 attenuated the inhibition of miR-204 on tumor angiogenesis of HNSCC. Furthermore, overexpression of miR-204 enhanced sensitivity of cetuximab in HNSCC cells, this effect was attenuated by JAK2 overexpression too. Importantly, JAK2 expression was negatively correlated with miR-204 level in HNSCC tissues. Therefore, miR-204 acts as a tumor suppressor by blocking JAK2/STAT3 pathway in HNSCC cells. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

Effect of miRNA-203 on cervical cancer cells and its underlying mechanism.

PubMed

Yin, X Z; Zhao, D M; Zhang, G X; Liu, L

2016-09-23

miRNA-203 is involved in the development and progression of various types of cancer. However, its role in cervical cancer remains unclear. The aim of this study was to investigate the effect of miRNA-203 on the proliferation and migration of HeLa cervical cancer cells, as well as survivin expression in these cells. A miRNA-203 primer probe was designed according to a sequence obtained from NCBI. The expression of miRNA-203 in cervical epithelial cells and cervical cancer cells was detected by quantitative reverse transcriptase-polymerase chain reaction. The miRNA-203 expression pattern was compared between these two cell lines. The cervical cancer cells were transfected with miRNA-203 mimic or inhibitor to determine their effects on proliferation and migration. The expression of the miRNA-203 target protein (survivin) was analyzed by western blot. Cervical cancer cells showed reduced miRNA-203 expression compared to cervical epithelial cells. Transfection of miRNA-203 mimic upregulated the expression of miRNA-203, suppressed cell proliferation and migration, and downregulated survivin expression (P < 0.05). However, downregulation of miRNA-203 expression did not affect proliferation, migration, and survivin expression in cervical cancer cells (P > 0.05). In conclusion, upregulation of miRNA-203 in cervical cancer cells inhibits the proliferative and migratory capacities of these cells by downregulating the expression of survivin.

miR-204-5p suppresses cell proliferation by inhibiting IGFBP5 in papillary thyroid carcinoma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Lianyong; Wang, Jingnan; Li, Xiangqi

2015-02-20

microRNAs (miRNAs) are frequently dysregulated in human malignancies. It was recently shown that miR-204-5p is downregulated in papillary thyroid carcinoma (PTC); however, the functional significance of this observation is not known. This study investigated the role of miR-204-5p in PTC. Overexpressing miR-204-5p suppressed PTC cell proliferation and induced cell cycle arrest and apoptosis. The results of a luciferase reporter assay showed that miR-204-5p can directly bind to the 3′ untranslated region (UTR) of insulin-like growth factor-binding protein 5 (IGFBP5) mRNA, and IGFBP5 overexpression partially reversed the growth-inhibitory effects of miR-204-5p. These results indicate that miR-204-5p acts as a tumor suppressormore » in PTC by regulating IGFBP5 expression and that miR-204-5p can potentially serve as an antitumorigenic agent in the treatment of PTC. - Highlights: • miR-204-5p expression is downregulated in PTC tissues and cell lines. • miR-204-5p suppresses proliferation and promotes apoptosis in PTC cells. • miR-204-5p suppresses IGFBP5 expression by direct binding to the 3′-UTR. • IGFBP5 overexpression reverses the effects of miR-204-5p.« less

Assessment of the quality of medication information for patients in Spain.

PubMed

Mira, José Joaquín; Lorenzo, Susana; Pérez-Jover, Virtudes; Navarro, Isabel; Martín de Rosales, Ana María; Lara, Catalina

2013-01-01

To analyze the extent to which Spanish leaflets and drug information on the Net met quality criteria. A descriptive study was conducted comparing readability (REA) and comprehensibility (COM) criteria of a random sample of 77 marketed products of the 12 active ingredients most frequently sold in 2010 in Spain. Leaflets were approved by the Spanish Agency for Medication (AEMPS). Flesch index, DISCERN, ELF, MIDAS and CIRF scales were used to evaluate quality criteria. COM assessment yielded between 63 and 77% of the maximum possible scores on the scales. None of the websites or leaflets met all the quality criteria of the DISCERN, CIRF or MIDAS scales. Four (3%) leaflets met all the 22 quality criteria of ELF. The leaflets showed shortcomings regarding: medication benefits (17 required substantial improvements, 31.5%), correct forms of storage (13, 24.1%), contraindications (12, 22.2%), side effects (11, 20.4%) and precautions to be taken (9, 16.7%). The quality of the information approved by the AEMPS is superior to that which can be found by surfing the Net. More specific information on precautions, complications and how to avoid common patient errors would allow patients the best chance to contribute to their own clinical safety.

15 CFR 270.310 - Evidence collected by investigation participants who are not NIST employees.

Code of Federal Regulations, 2012 CFR

2012-01-01

... participants who are not NIST employees. 270.310 Section 270.310 Commerce and Foreign Trade Regulations... Collection of Evidence § 270.310 Evidence collected by investigation participants who are not NIST employees... is not a NIST employee shall: (a) As soon as practicable, transfer the original evidence to NIST, and...

15 CFR 270.310 - Evidence collected by investigation participants who are not NIST employees.

Code of Federal Regulations, 2011 CFR

2011-01-01

... participants who are not NIST employees. 270.310 Section 270.310 Commerce and Foreign Trade Regulations... Collection of Evidence § 270.310 Evidence collected by investigation participants who are not NIST employees... is not a NIST employee shall: (a) As soon as practicable, transfer the original evidence to NIST, and...

15 CFR 270.310 - Evidence collected by investigation participants who are not NIST employees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... participants who are not NIST employees. 270.310 Section 270.310 Commerce and Foreign Trade Regulations... Collection of Evidence § 270.310 Evidence collected by investigation participants who are not NIST employees... is not a NIST employee shall: (a) As soon as practicable, transfer the original evidence to NIST, and...

15 CFR 270.310 - Evidence collected by investigation participants who are not NIST employees.

Code of Federal Regulations, 2014 CFR

2014-01-01

... participants who are not NIST employees. 270.310 Section 270.310 Commerce and Foreign Trade Regulations... Collection of Evidence § 270.310 Evidence collected by investigation participants who are not NIST employees... is not a NIST employee shall: (a) As soon as practicable, transfer the original evidence to NIST, and...

15 CFR 270.310 - Evidence collected by investigation participants who are not NIST employees.

Code of Federal Regulations, 2013 CFR

2013-01-01

... participants who are not NIST employees. 270.310 Section 270.310 Commerce and Foreign Trade Regulations... Collection of Evidence § 270.310 Evidence collected by investigation participants who are not NIST employees... is not a NIST employee shall: (a) As soon as practicable, transfer the original evidence to NIST, and...

22 CFR 208.310 - What must I do if a Federal agency excludes a person with whom I am already doing business in a...

Code of Federal Regulations, 2011 CFR

2011-04-01

... person with whom I am already doing business in a covered transaction? 208.310 Section 208.310 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Responsibilities of Participants Regarding Transactions Doing Business with Other Persons § 208.310 What must I do...

22 CFR 208.310 - What must I do if a Federal agency excludes a person with whom I am already doing business in a...

Code of Federal Regulations, 2010 CFR

2010-04-01

... person with whom I am already doing business in a covered transaction? 208.310 Section 208.310 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Responsibilities of Participants Regarding Transactions Doing Business with Other Persons § 208.310 What must I do...

27 CFR 19.310 - Wash water.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Wash water. 19.310 Section 19.310 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF... Byproducts § 19.310 Wash water. Water used in washing chemicals to remove spirits may be run into a wash tank...

7 CFR 1437.310 - Sea grass and sea oats.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 10 2012-01-01 2012-01-01 false Sea grass and sea oats. 1437.310 Section 1437.310 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT... Determining Coverage Using Value § 1437.310 Sea grass and sea oats. (a) Sea grass and sea oats are value loss...

7 CFR 1437.310 - Sea grass and sea oats.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 10 2013-01-01 2013-01-01 false Sea grass and sea oats. 1437.310 Section 1437.310 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT... Determining Coverage Using Value § 1437.310 Sea grass and sea oats. (a) Sea grass and sea oats are value loss...

7 CFR 1437.310 - Sea grass and sea oats.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 10 2014-01-01 2014-01-01 false Sea grass and sea oats. 1437.310 Section 1437.310 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT... Determining Coverage Using Value § 1437.310 Sea grass and sea oats. (a) Sea grass and sea oats are value loss...

13 CFR 120.310 - What assistance is available for the disabled?

Code of Federal Regulations, 2011 CFR

2011-01-01

... the disabled? 120.310 Section 120.310 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Special Purpose Loans Disabled Assistance Loan Program (dal) § 120.310 What assistance is available for the disabled? Section 7(a)(10) of the Act authorizes SBA to guarantee or make direct loans to...

13 CFR 120.310 - What assistance is available for the disabled?

Code of Federal Regulations, 2014 CFR

2014-01-01

... the disabled? 120.310 Section 120.310 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Special Purpose Loans Disabled Assistance Loan Program (dal) § 120.310 What assistance is available for the disabled? Section 7(a)(10) of the Act authorizes SBA to guarantee or make direct loans to...

13 CFR 120.310 - What assistance is available for the disabled?

Code of Federal Regulations, 2012 CFR

2012-01-01

... the disabled? 120.310 Section 120.310 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Special Purpose Loans Disabled Assistance Loan Program (dal) § 120.310 What assistance is available for the disabled? Section 7(a)(10) of the Act authorizes SBA to guarantee or make direct loans to...

13 CFR 120.310 - What assistance is available for the disabled?

Code of Federal Regulations, 2010 CFR

2010-01-01

... the disabled? 120.310 Section 120.310 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Special Purpose Loans Disabled Assistance Loan Program (dal) § 120.310 What assistance is available for the disabled? Section 7(a)(10) of the Act authorizes SBA to guarantee or make direct loans to...

13 CFR 120.310 - What assistance is available for the disabled?

Code of Federal Regulations, 2013 CFR

2013-01-01

... the disabled? 120.310 Section 120.310 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Special Purpose Loans Disabled Assistance Loan Program (dal) § 120.310 What assistance is available for the disabled? Section 7(a)(10) of the Act authorizes SBA to guarantee or make direct loans to...

46 CFR 129.310 - Power sources.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Power sources. 129.310 Section 129.310 Shipping COAST... Power Sources and Distribution Systems § 129.310 Power sources. (a)(1) Each vessel that relies on electricity to power the following loads must be arranged so that the loads can be energized from at least two...

46 CFR 129.310 - Power sources.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Power Sources and Distribution Systems § 129.310 Power sources. (a)(1) Each vessel that relies on electricity to power the following loads must be arranged so that the loads can be energized from at least two... 46 Shipping 4 2011-10-01 2011-10-01 false Power sources. 129.310 Section 129.310 Shipping COAST...

46 CFR 129.310 - Power sources.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Power Sources and Distribution Systems § 129.310 Power sources. (a)(1) Each vessel that relies on electricity to power the following loads must be arranged so that the loads can be energized from at least two... 46 Shipping 4 2014-10-01 2014-10-01 false Power sources. 129.310 Section 129.310 Shipping COAST...

46 CFR 129.310 - Power sources.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Power Sources and Distribution Systems § 129.310 Power sources. (a)(1) Each vessel that relies on electricity to power the following loads must be arranged so that the loads can be energized from at least two... 46 Shipping 4 2012-10-01 2012-10-01 false Power sources. 129.310 Section 129.310 Shipping COAST...

46 CFR 129.310 - Power sources.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Power Sources and Distribution Systems § 129.310 Power sources. (a)(1) Each vessel that relies on electricity to power the following loads must be arranged so that the loads can be energized from at least two... 46 Shipping 4 2013-10-01 2013-10-01 false Power sources. 129.310 Section 129.310 Shipping COAST...