Science.gov

Sample records for aashto lrfd specifications

  1. 23 CFR 625.4 - Standards, policies, and standard specifications.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    .... (b) Bridges and structures. (1) Standard Specifications for Highway Bridges, Fifteenth Edition, AASHTO 1992. (2) Interim Specifications—Bridges, AASHTO 1993. (3) Interim Specifications—Bridges, AASHTO 1994. (4) Interim Specifications—Bridges, AASHTO 1995. (5) AASHTO LRFD Bridge Design...

  2. Re-Evaluation of the AASHTO-Flexible Pavement Design Equation with Neural Network Modeling

    PubMed Central

    Tiğdemir, Mesut

    2014-01-01

    Here we establish that equivalent single-axle loads values can be estimated using artificial neural networks without the complex design equality of American Association of State Highway and Transportation Officials (AASHTO). More importantly, we find that the neural network model gives the coefficients to be able to obtain the actual load values using the AASHTO design values. Thus, those design traffic values that might result in deterioration can be better calculated using the neural networks model than with the AASHTO design equation. The artificial neural network method is used for this purpose. The existing AASHTO flexible pavement design equation does not currently predict the pavement performance of the strategic highway research program (Long Term Pavement Performance studies) test sections very accurately, and typically over-estimates the number of equivalent single axle loads needed to cause a measured loss of the present serviceability index. Here we aimed to demonstrate that the proposed neural network model can more accurately represent the loads values data, compared against the performance of the AASHTO formula. It is concluded that the neural network may be an appropriate tool for the development of databased-nonparametric models of pavement performance. PMID:25397962

  3. Re-evaluation of the AASHTO-flexible pavement design equation with neural network modeling.

    PubMed

    Tiğdemir, Mesut

    2014-01-01

    Here we establish that equivalent single-axle loads values can be estimated using artificial neural networks without the complex design equality of American Association of State Highway and Transportation Officials (AASHTO). More importantly, we find that the neural network model gives the coefficients to be able to obtain the actual load values using the AASHTO design values. Thus, those design traffic values that might result in deterioration can be better calculated using the neural networks model than with the AASHTO design equation. The artificial neural network method is used for this purpose. The existing AASHTO flexible pavement design equation does not currently predict the pavement performance of the strategic highway research program (Long Term Pavement Performance studies) test sections very accurately, and typically over-estimates the number of equivalent single axle loads needed to cause a measured loss of the present serviceability index. Here we aimed to demonstrate that the proposed neural network model can more accurately represent the loads values data, compared against the performance of the AASHTO formula. It is concluded that the neural network may be an appropriate tool for the development of databased-nonparametric models of pavement performance.

  4. 75 FR 38593 - Buy America Waiver Notification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-02

    ... 635.410 requires a domestic manufacturing process for any steel or iron products (including protective... original machinery that meets Federal design code, AASHTO LRFD for Movable Highway Bridge...

  5. Towards multiple hazard resilient bridges: a methodology for modeling frequent and infrequent time-varying loads Part II, Examples for live and earthquake load effects

    NASA Astrophysics Data System (ADS)

    Liang, Zach; Lee, George C.

    2012-09-01

    The current AASHTO load and resistance factor design (LRFD) guidelines are formulated based on bridge reliability, which interprets traditional design safety factors into more rigorously deduced factors based on the theory of probability. This is a major advancement in bridge design specifications. However, LRFD is only calibrated for dead and live loads. In cases when extreme loads are significant, they need to be individually assessed. Combining regular loads with extreme loads has been a major challenge, mainly because the extreme loads are time variable and cannot be directly combined with time invariant loads to formulate the probability of structural failure. To overcome these difficulties, this paper suggests a methodology of comprehensive reliability, by introducing the concept of partial failure probability to separate the loads so that each individual load combination under a certain condition can be approximated as time invariant. Based on these conditions, the extreme loads (also referred to as multiple hazard or MH loads) can be broken down into single effects. In this paper, a further breakdown of these conditional occurrence probabilities into pure conditions is discussed by using a live truck and earthquake loads on a bridge as an example.

  6. Towards multiple hazard resilient bridges: a methodology for modeling frequent and infrequent time-varying loads Part I, Comprehensive reliability and partial failure probabilities

    NASA Astrophysics Data System (ADS)

    Liang, Zach; Lee, George C.

    2012-09-01

    The current AASHTO load and resistance factor design (LRFD) guidelines are formulated based on bridge reliability, which interprets traditional design safety factors into more rigorously deduced factors based on the theory of probability. This is a major advancement in bridge design specifications. However, LRFD is only calibrated for dead and live loads. In cases when extreme loads are significant, they need to be individually assessed. Combining regular loads with extreme loads has been a major challenge, mainly because the extreme loads are time variables and cannot be directly combined with time invariant loads to formulate the probability of structural failure. To overcome these difficulties, this paper suggests a methodology of comprehensive reliability, by introducing the concept of partial failure probability to separate the loads so that each individual load combination under a certain condition can be approximated as time invariant. Based on these conditions, the extreme loads (also referred to as multiple hazard or MH loads) can be broken down into single effects. In Part II of this paper, a further breakdown of these conditional occurrence probabilities into pure conditions is discussed by using a live truck and earthquake loads on a bridge as an example. There are three major steps in establishing load factors from MH load distributions: (1) formulate the failure probabilities; (2) normalize various load distributions; and (3) establish design limit state equations. This paper describes the formulation of the failure probabilities of single and combined loads.

  7. Bridge pier failure probabilities under combined hazard effects of scour, truck and earthquake. Part II: failure probabilities

    NASA Astrophysics Data System (ADS)

    Liang, Zach; Lee, George C.

    2013-06-01

    In many regions of the world, a bridge will experience multiple extreme hazards during its expected service life. The current American Association of State Highway and Transportation Officials (AASHTO) load and resistance factor design (LRFD) specifications are formulated based on failure probabilities, which are fully calibrated for dead load and non-extreme live loads. Design against earthquake load effect is established separately. Design against scour effect is also formulated separately by using the concept of capacity reduction (or increased scour depth). Furthermore, scour effect cannot be linked directly to an LRFD limit state equation because the latter is formulated using force-based analysis. This paper (in two parts) presents a probability-based procedure to estimate the combined hazard effects on bridges due to truck, earthquake and scour, by treating the effect of scour as an equivalent load effect so that it can be included in reliability-based failure calculations. In Part I of this series, the general principle for treating the scour depth as an equivalent load effect is presented. In Part II, the corresponding bridge failure probability, the occurrence of scour as well as simultaneously having both truck load and equivalent scour load effect are quantitatively discussed. The key formulae of the conditional partial failure probabilities and the necessary conditions are established. In order to illustrate the methodology, an example of dead, truck, earthquake and scour effects on a simple bridge pile foundation is represented.

  8. Bridge pier failure probabilities under combined hazard effects of scour, truck and earthquake. Part I: occurrence probabilities

    NASA Astrophysics Data System (ADS)

    Liang, Zach; Lee, George C.

    2013-06-01

    In many regions of the world, a bridge will experience multiple extreme hazards during its expected service life. The current American Association of State Highway and Transportation Officials (AASHTO) load and resistance factor design (LRFD) specifications are formulated based on failure probabilities, which are fully calibrated for dead load and nonextreme live loads. Design against earthquake loads is established separately. Design against scour effect is also formulated separately by using the concept of capacity reduction (or increased scour depth). Furthermore, scour effect cannot be linked directly to an LRFD limit state equation, because the latter is formulated using force-based analysis. This paper (in two parts) presents a probability-based procedure to estimate the combined hazard effects on bridges due to truck, earthquake and scour, by treating the effect of scour as an equivalent load effect so that it can be included in reliability-based bridge failure calculations. In Part I of this series, the general principle of treating the scour depth as an equivalent load effect is presented. The individual and combined partial failure probabilities due to truck, earthquake and scour effects are described. To explain the method of including non-force-based natural hazards effects, two types of common scour failures are considered. In Part II, the corresponding bridge failure probability, the occurrence of scour as well as simultaneously having both truck load and equivalent scour load are quantitatively discussed.

  9. Tests and specifications pertinent to coal ash utilization

    SciTech Connect

    Manz, O.

    1994-12-31

    Fortunately, in the United States, most of the test methods and specifications for the use of coal ash in cement, concrete, lime, or soil-related products are found in the American Society for Testing and Materials (ASTM) books of standards. Many of the same or slightly different specifications are also found in the American Association of State Highway and Transportation Officials (AASHTO) books of standards, as well as those of the various Departments of Transportation (DOTs). Other specifications for selected uses are found in publications of the American Petroleum Institute (API), the Sulfur Institute, the mineral wool industry, and West Virginia University. It is difficult to keep up with the most recent printed specifications, particularly in ASTM, since the committees meet twice yearly and have many time-consuming ballots. This paper summarizes the critical engineering properties required to assess the utilization applications of coal ash products. For most uses, both physical and chemical limits are specified. There are specifications for blended cement containing fly ash, for sulfate resistance, and for alkali aggregate reaction, also for fly ash for use in concrete, in oil well cement, and in grout. Coal ash is specified for use in ash-lime stabilization, as lightweight aggregate, and for mineral filler, as well as for structural fill and flowable fill. Other uses include sulfur concrete, high flexural strength ceramics, mineral wool, brick, cenospheres, and filler.

  10. A Brillouin smart FRP material and a strain data post processing software for structural health monitoring through laboratory testing and field application on a highway bridge

    NASA Astrophysics Data System (ADS)

    Bastianini, Filippo; Matta, Fabio; Galati, Nestore; Nanni, Antonio

    2005-05-01

    Strain and temperature sensing obtained through frequency shift evaluation of Brillouin scattered light is a technology that seems extremely promising for Structural Health Monitoring (SHM). Due to the intrinsic distributed sensing capability, Brillouin can measure the deformation of any individual segment of huge lengths of inexpensive single-mode fiber. In addition, Brillouin retains other typical advantages of Fiber Optic Sensors (FOS), such as harsh environment durability and interference rejection. Despite these advantages, the diffusion of Brillouin for SHM is constrained by different factors, such as the high equipment cost, the commercial unavailability of specific SHM oriented fiber products and even some prejudices on the required sensitivity performances. In the present work, a complete SHM pilot application was developed, installed and successfully operated during a diagnostic load test on the High Performance Steel (HPS) bridge A6358 located at the Lake of the Ozarks (Miller County, MO, USA). Four out of five girders were extensively instrumented with a "smart" Glass Fiber Reinforced Polymer (GFRP) tape having embedded fibers for strain sensing and thermal compensation. Data collected during a diagnostic load test were elaborated through a specific post-processing software, and the strain profiles retrieved were compared to traditional strain gauges and theoretical results based on the AASHTO LRFD Bridge Design Specifications for structural assessment purposes. The excellent results obtained confirm the effectiveness of Brillouin SHM systems for the monitoring of real applications.

  11. Refinement of Strut-and-Tie Model for Reinforced Concrete Deep Beams.

    PubMed

    Panjehpour, Mohammad; Chai, Hwa Kian; Voo, Yen Lei

    2015-01-01

    Deep beams are commonly used in tall buildings, offshore structures, and foundations. According to many codes and standards, strut-and-tie model (STM) is recommended as a rational approach for deep beam analyses. This research focuses on the STM recommended by ACI 318-11 and AASHTO LRFD and uses experimental results to modify the strut effectiveness factor in STM for reinforced concrete (RC) deep beams. This study aims to refine STM through the strut effectiveness factor and increase result accuracy. Six RC deep beams with different shear span to effective-depth ratios (a/d) of 0.75, 1.00, 1.25, 1.50, 1.75, and 2.00 were experimentally tested under a four-point bending set-up. The ultimate shear strength of deep beams obtained from non-linear finite element modeling and STM recommended by ACI 318-11 as well as AASHTO LRFD (2012) were compared with the experimental results. An empirical equation was proposed to modify the principal tensile strain value in the bottle-shaped strut of deep beams. The equation of the strut effectiveness factor from AASHTTO LRFD was then modified through the aforementioned empirical equation. An investigation on the failure mode and crack propagation in RC deep beams subjected to load was also conducted.

  12. Refinement of Strut-and-Tie Model for Reinforced Concrete Deep Beams

    PubMed Central

    Panjehpour, Mohammad; Chai, Hwa Kian; Voo, Yen Lei

    2015-01-01

    Deep beams are commonly used in tall buildings, offshore structures, and foundations. According to many codes and standards, strut-and-tie model (STM) is recommended as a rational approach for deep beam analyses. This research focuses on the STM recommended by ACI 318-11 and AASHTO LRFD and uses experimental results to modify the strut effectiveness factor in STM for reinforced concrete (RC) deep beams. This study aims to refine STM through the strut effectiveness factor and increase result accuracy. Six RC deep beams with different shear span to effective-depth ratios (a/d) of 0.75, 1.00, 1.25, 1.50, 1.75, and 2.00 were experimentally tested under a four-point bending set-up. The ultimate shear strength of deep beams obtained from non-linear finite element modeling and STM recommended by ACI 318-11 as well as AASHTO LRFD (2012) were compared with the experimental results. An empirical equation was proposed to modify the principal tensile strain value in the bottle-shaped strut of deep beams. The equation of the strut effectiveness factor from AASHTTO LRFD was then modified through the aforementioned empirical equation. An investigation on the failure mode and crack propagation in RC deep beams subjected to load was also conducted. PMID:26110268

  13. Towards establishing practical multi-hazard bridge design limit states

    NASA Astrophysics Data System (ADS)

    Liang, Zach; Lee, George C.

    2013-09-01

    In the U.S., the current Load and Resistance Factor Design (LRFD) Specifications for highway bridges is a reliability-based formulation that considers failure probabilities of bridge components due to the actions of typical dead load and frequent vehicular loads. Various extreme load effects, such as earthquake and vessel collision, are not considered on the same reliability-based platform. Since these extreme loads are time variables, combining them with frequent, nonextreme loads is a significant challenge. The number of design limit state equations based on these failure probabilities can be unrealistically large and unnecessary from the view point of practical applications. Based on the opinion of AASHTO State Bridge Engineers, many load combinations are insignificant in their states. This paper describes the formulation of a criterion to include only the necessary load combinations to establish the design limit states. This criterion is established by examining the total failure probabilities for all possible time-invariant and time varying load combinations and breaking them down into partial terms. Then, important load combinations can be readily determined quantitatively.

  14. Evaluation of seismic design spectrum based on UHS implementing fourth-generation seismic hazard maps of Canada

    NASA Astrophysics Data System (ADS)

    Ahmed, Ali; Hasan, Rafiq; Pekau, Oscar A.

    2016-12-01

    Two recent developments have come into the forefront with reference to updating the seismic design provisions for codes: (1) publication of new seismic hazard maps for Canada by the Geological Survey of Canada, and (2) emergence of the concept of new spectral format outdating the conventional standardized spectral format. The fourth -generation seismic hazard maps are based on enriched seismic data, enhanced knowledge of regional seismicity and improved seismic hazard modeling techniques. Therefore, the new maps are more accurate and need to incorporate into the Canadian Highway Bridge Design Code (CHBDC) for its next edition similar to its building counterpart National Building Code of Canada (NBCC). In fact, the code writers expressed similar intentions with comments in the commentary of CHBCD 2006. During the process of updating codes, NBCC, and AASHTO Guide Specifications for LRFD Seismic Bridge Design, American Association of State Highway and Transportation Officials, Washington (2009) lowered the probability level from 10 to 2% and 10 to 5%, respectively. This study has brought five sets of hazard maps corresponding to 2%, 5% and 10% probability of exceedance in 50 years developed by the GSC under investigation. To have a sound statistical inference, 389 Canadian cities are selected. This study shows the implications of the changes of new hazard maps on the design process (i.e., extent of magnification or reduction of the design forces).

  15. Safety identifying of integral abutment bridges under seismic and thermal loads.

    PubMed

    Easazadeh Far, Narges; Barghian, Majid

    2014-01-01

    Integral abutment bridges (IABs) have many advantages over conventional bridges in terms of strength and maintenance cost. Due to the integrity of these structures uniform thermal and seismic loads are known important ones on the structure performance. Although all bridge design codes consider temperature and earthquake loads separately in their load combinations for conventional bridges, the thermal load is an "always on" load and, during the occurrence of an earthquake, these two important loads act on bridge simultaneously. Evaluating the safety level of IABs under combination of these loads becomes important. In this paper, the safety of IABs--designed by AASHTO LRFD bridge design code--under combination of thermal and seismic loads is studied. To fulfill this aim, first the target reliability indexes under seismic load have been calculated. Then, these analyses for the same bridge under combination of thermal and seismic loads have been repeated and the obtained reliability indexes are compared with target indexes. It is shown that, for an IAB designed by AASHTO LRFD, the indexes have been reduced under combined effects. So, the target level of safety during its design life is not provided and the code's load combination should be changed.

  16. Safety Identifying of Integral Abutment Bridges under Seismic and Thermal Loads

    PubMed Central

    Easazadeh Far, Narges; Barghian, Majid

    2014-01-01

    Integral abutment bridges (IABs) have many advantages over conventional bridges in terms of strength and maintenance cost. Due to the integrity of these structures uniform thermal and seismic loads are known important ones on the structure performance. Although all bridge design codes consider temperature and earthquake loads separately in their load combinations for conventional bridges, the thermal load is an “always on” load and, during the occurrence of an earthquake, these two important loads act on bridge simultaneously. Evaluating the safety level of IABs under combination of these loads becomes important. In this paper, the safety of IABs—designed by AASHTO LRFD bridge design code—under combination of thermal and seismic loads is studied. To fulfill this aim, first the target reliability indexes under seismic load have been calculated. Then, these analyses for the same bridge under combination of thermal and seismic loads have been repeated and the obtained reliability indexes are compared with target indexes. It is shown that, for an IAB designed by AASHTO LRFD, the indexes have been reduced under combined effects. So, the target level of safety during its design life is not provided and the code's load combination should be changed. PMID:25405232

  17. Specification Reformulation During Specification Validation

    NASA Technical Reports Server (NTRS)

    Benner, Kevin M.

    1992-01-01

    The goal of the ARIES Simulation Component (ASC) is to uncover behavioral errors by 'running' a specification at the earliest possible points during the specification development process. The problems to be overcome are the obvious ones the specification may be large, incomplete, underconstrained, and/or uncompilable. This paper describes how specification reformulation is used to mitigate these problems. ASC begins by decomposing validation into specific validation questions. Next, the specification is reformulated to abstract out all those features unrelated to the identified validation question thus creating a new specialized specification. ASC relies on a precise statement of the validation question and a careful application of transformations so as to preserve the essential specification semantics in the resulting specialized specification. This technique is a win if the resulting specialized specification is small enough so the user my easily handle any remaining obstacles to execution. This paper will: (1) describe what a validation question is; (2) outline analysis techniques for identifying what concepts are and are not relevant to a validation question; and (3) identify and apply transformations which remove these less relevant concepts while preserving those which are relevant.

  18. Military specifications

    NASA Technical Reports Server (NTRS)

    Reynolds, Philip

    1987-01-01

    The current situation relative to the military specification is that there is not one specific model of turbulence which people are using. Particular disagreement exists on how turbulence levels will vary with qualitative analysis. It does not tie one down to specifics. When it comes to flying quality specifications, many feel that one should stay with the definitions of the Cooper-Harper rating scale but allow the levels to shift depending on the level of turbulence. There is a ride quality specification in the MIL-SPEC having to do with flight control systems design that is related to a turbulence model. This spec (MIL-F8785C) and others are discussed.

  19. Specifying Specification.

    PubMed

    Paulo, Norbert

    2016-03-01

    This paper tackles the accusation that applied ethics is no serious academic enterprise because it lacks theoretical bracing. It does so in two steps. In the first step I introduce and discuss a highly acclaimed method to guarantee stability in ethical theories: Henry Richardson's specification. The discussion shows how seriously ethicists take the stability of the connection between the foundational parts of their theories and their further development as well as their "application" to particular problems or cases. A detailed scrutiny of specification leads to the second step, where I use insights from legal theory to inform the debate around stability from that point of view. This view reveals some of specification's limitations. I suggest that, once specification is sufficiently specified, it appears astonishingly similar to deduction as used in legal theory. Legal theory also provides valuable insight into the functional range of deduction and its relation to other forms of reasoning. This leads to a richer understanding of stability in normative theories and to a smart division of labor between deduction and other forms of reasoning. The comparison to legal theory thereby provides a framework for how different methods such as specification, deduction, balancing, and analogy relate to one another.

  20. Specific Suspicion

    ERIC Educational Resources Information Center

    Taylor, Kelley R.

    2009-01-01

    This article discusses a recent case decided by the U.S. Supreme Court which highlights the importance of having specific suspicions of misbehavior before conducting a strip search. The case involves an eighth-grade female student who was being strip-searched by a middle school assistant principal, a school nurse, and an administrative assistant…

  1. Intent Specifications

    NASA Technical Reports Server (NTRS)

    Leveson, Nancy G.

    1995-01-01

    We have been investigating the implications of using abstractions based on intent rather than the aggregation and information-hiding abstractions commonly used in software en- gineering: Cognitive psychologists have shown that intent abstraction is consistent with human problem-solving processes. We believe that new types of specifications and designs based on this concept can assist in understanding and specifying requirements, capturing the most important design rationale information in an efficient and economical way, and supporting the process of identifying and analyzing required changes to minimize the introduction of errors. The goal of hierarchical abstraction is to allow both top-down and bottom-up reasoning about a complex system. In computer science, we have made much use of (1) part-whole abstractions where each level of a hierarchy represents an aggregation of the components at a lower level and of (2) information-hiding abstractions where each level contains the same conceptual information but hides some details about the concepts, that is, each level is a refinement of the information at a higher level.

  2. Specific phobias.

    PubMed

    Hamm, Alfons O

    2009-09-01

    Exposure based treatments in which patients are systematically confronted with their feared objects of situations are highly effective in the treatment of specific phobias and produce stable improvement both in reported fear and behavioral avoidance. Exposure in reality is more effective in most cases than exposure in sensu. For situations that are difficult to realize, exposure in virtual environments has become increasingly valuable. Exposure in vivo is clearly superior to pharmacotherapy, although cognitive enhancers have been successfully used recently to increase the effect of exposure therapy. The induction of relaxation is not a necessary precondition for exposure therapy. Rather the current mechanisms of change focus on extinction learning as being the central mechanism both on a cognitive level namely that the feared object is no longer associated with severely threatening consequence but also on an affective level, meaning that feared cue is no longer capable to activate the fear circuit in the brain. Accordingly future diagnostic categorizations of phobic disorders in the DSM-V should rather focus on the pattern of the fear response that needs to be changed than on the eliciting cues or situations that are avoided.

  3. Mining Specifications: A Roadmap

    NASA Astrophysics Data System (ADS)

    Zeller, Andreas

    Recent advances in software validation and verification make it possible to widely automate whether a specification is satisfied. This progress is hampered, though, by the persistent difficulty of writing specifications. Are we facing a “specification crisis”? In this paper, I show how to alleviate the burden of writing specifications by reusing and extending specifications as mined from existing software and give an overview on the state of the art in specification mining, its origins, and its potential.

  4. Urine specific gravity test

    MedlinePlus

    ... medlineplus.gov/ency/article/003587.htm Urine specific gravity test To use the sharing features on this page, please enable JavaScript. Urine specific gravity is a laboratory test that shows the concentration ...

  5. Specific heat revisited

    NASA Astrophysics Data System (ADS)

    Pizarro, C. A.; Condat, C. A.; Lamberti, P. W.; Prato, D. P.

    1996-06-01

    The correlation between potential shape and specific heat is generally absent from textbook discussions. We present a detailed analysis of the specific heat contribution due to independent particles subject to one-dimensional classical and quantum model potentials. For the classical models, we use phase space concepts to develop a clear physical interpretation of the temperature dependence of the specific heat. For the quantum models, we make the interpretation in terms of the differences in quantum levels.

  6. [Specific dermatoses of pregnancy].

    PubMed

    Teixeira, Vera; Coutinho, Inês; Gameiro, Rita; Vieira, Ricardo; Gonçalo, Margarida

    2013-01-01

    During pregnancy immunological, metabolic, hormonal and vascular changes occur, and can cause specific skin diseases. The specific dermatoses of pregnancy have undergone numerous changes in nomenclature and classification, partly due to advances in the knowledge of the pathogenesis of these skin diseases. Currently the following diseases are considered specific dermatoses of pregnancy: pemphigoid gestations, polymorphic eruption of pregnancy, intrahepatic cholestasis of pregnancy and atopic eruption of pregnancy. Timely diagnosis and specific and safe treatment are essential to prevent complications which, although rare, may be associated with significant maternal-fetal comorbidity.

  7. Improved technical specifications

    SciTech Connect

    Hoffman, D.R.

    1994-12-31

    Improved technical specifications for nuclear power plants are outlined. The objectives of this work are to improve safety, provide a clearer understanding of safety significance, and ease NRC and industry administrative burdens. Line item improvements, bases, and implementation of the specifications are discussed.

  8. Prototype Facility Educational Specifications.

    ERIC Educational Resources Information Center

    Idaho State Div. of Professional-Technical Education, Boise.

    This document presents prototypical educational specifications to guide the building and renovation of Idaho vocational schools so they can help communities meet the advanced, professional-technical programs of the future. The specifications start with points to consider when determining school site suitability. The document then sets forth…

  9. Languages for Specific Purposes.

    ERIC Educational Resources Information Center

    Swales, John M.

    2000-01-01

    Focuses on languages for specific purposes, providing a brief historical perspective, examining it as a profession, discipline, or neither; its role in science and law; language for business purposes; and the position of English worldwide. (Author/VWL)

  10. TWRSview system requirements specification

    SciTech Connect

    Caldwell, J.A.; Lee, A.K.

    1995-12-01

    This document provides the system requirements specification for the TWRSview software system. The TWRSview software system is being developed to integrate electronic data supporting the development of the TWRS technical baseline

  11. Phobia - simple/specific

    MedlinePlus

    ... enable JavaScript. A phobia is an ongoing intense fear or anxiety of a certain object, animal, activity, ... panic attack when exposed to the object of fear. Specific phobias are a common mental disorder. Common ...

  12. VOST charcoal specification study

    SciTech Connect

    Foster, A.L.; Bursey, J.T.

    1995-07-01

    The volatile organic sampling train, SW-846 Method 0030, (VOST) is currently one of the leading methodology`s available for the sampling and analysis of volatile organic hazardous compounds from stationary sources at very low levels. The method does not identify a specific equivalent sorbent, nor the performance specifications which would allow determination of an equivalent. Lot 104 petroleum-based charcoal is no longer commercially available. Laboratories are presently using a wide range of substitutes with varying performance from batch to batch of charcoal. To provide performance specifications and identify a replacement for SKC Lot 104 charcoal, a VOST charcoal specification study was initiated. Performance, cost, ease of handling, and plentiful supply make Anasorb 747 a good choice for replacement of SKX Lot 104.

  13. Specific Genetic Disorders

    MedlinePlus

    ... of Genetic Terms Definitions for genetic terms Specific Genetic Disorders Many human diseases have a genetic component. ... Condition in an Adult The Undiagnosed Diseases Program Genetic Disorders Achondroplasia Alpha-1 Antitrypsin Deficiency Antiphospholipid Syndrome ...

  14. Harmonization of Biodiesel Specifications

    SciTech Connect

    Alleman, T. L.

    2008-02-01

    Worldwide biodiesel production has grown dramatically over the last several years. Biodiesel standards vary across countries and regions, and there is a call for harmonization. For harmonization to become a reality, standards have to be adapted to cover all feedstocks. Additionally, all feedstocks cannot meet all specifications, so harmonization will require standards to either tighten or relax. For harmonization to succeed, the biodiesel market must be expanded with the alignment of test methods and specification limits, not contracted.

  15. Lidar base specification

    USGS Publications Warehouse

    Heidemann, Hans Karl.

    2012-01-01

    In late 2009, a $14.3 million allocation from the “American Recovery and Reinvestment Act” for new light detection and ranging (lidar) elevation data prompted the U.S. Geological Survey (USGS) National Geospatial Program (NGP) to develop a common base specification for all lidar data acquired for The National Map. Released as a draft in 2010 and formally published in 2012, the USGS–NGP “Lidar Base Specification Version 1.0” (now Lidar Base Specification) was quickly embraced as the foundation for numerous state, county, and foreign country lidar specifications. Prompted by a growing appreciation for the wide applicability and inherent value of lidar, a USGS-led consortium of Federal agencies commissioned a National Enhanced Elevation Assessment (NEEA) study in 2010 to quantify the costs and benefits of a national lidar program. A 2012 NEEA report documented a substantial return on such an investment, defined five Quality Levels (QL) for elevation data, and recommended an 8-year collection cycle of Quality Level 2 (QL2) lidar data as the optimum balance of benefit and affordability. In response to the study, the USGS–NGP established the 3D Elevation Program (3DEP) in 2013 as the interagency vehicle through which the NEEA recommendations could be realized. Lidar is a fast evolving technology, and much has changed in the industry since the final draft of the “Lidar Base Specification Version 1.0” was written. Lidar data have improved in accuracy and spatial resolution, geospatial accuracy standards have been revised by the American Society for Photogrammetry and Remote Sensing (ASPRS), industry standard file formats have been expanded, additional applications for lidar have become accepted, and the need for interoperable data across collections has been realized. This revision to the “Lidar Base Specification Version 1.0” publication addresses those changes and provides continued guidance towards a nationally consistent lidar dataset.

  16. Automated Library System Specifications.

    DTIC Science & Technology

    1986-06-01

    AD-A78 95 AUTOMATED LIBRARY SYSTEM SPECIFICATIONS(U) ARMY LIBRARY /i MANAGEMENT OFFICE ALEXANDRIA VA ASSISTANT CHIEF OF STAFF FOR INFORMATION... MANAGEMENT M B BONNETT JUN 86 UNCLASSIFIED F/G 9/2 NLEElIIhllEEEEE IllEEEEEllllEI .1lm lliml * ~I fI.L25 MI, [OCM RL,;OCLUTO fl. ’N k~ AUTOMATED LIBRARY...SYSTEM SPECIFICATIONS .,I Prepared by Mary B. Bonnett ARMY LIBRARY MANAGEMENT OFFICE OFFICE OF THE ASSISTANT CHIEF OF STAFF FOR INFORMATION MANAGEMENT Lij

  17. Mask cost and specification

    NASA Astrophysics Data System (ADS)

    Watanabe, Hisashi; Higashikawa, Iwao

    2003-12-01

    At the panel discussion of Photomask Japan 2003, we discussed about Mask cost and specification. The topics are (1) Mask price trend and its impact, (2) How to reduce the mask costs; solutions from a mask shop, mask writing tool and mask inspection tool 3) Partnering mask suppliers with mask users; reasonable mask specification and OPC strategies. The choice of DUV laser writer instead of e-beam writer is one solution for reduction of mask cost. The continuous improvement of e-beam writer and resist sensitivity for high throughput is another solution. The partnership between designer, EDA vender, mask maker and wafer lithographer becomes more important.

  18. Lidar base specification

    USGS Publications Warehouse

    Heidemann, Hans Karl.

    2012-01-01

    Lidar is a fast evolving technology, and much has changed in the industry since the final draft of the “Lidar Base Specification Version 1.0” was written. Lidar data have improved in accuracy and spatial resolution, geospatial accuracy standards have been revised by the American Society for Photogrammetry and Remote Sensing (ASPRS), industry standard file formats have been expanded, additional applications for lidar have become accepted, and the need for interoperable data across collections has been realized. This revision to the “Lidar Base Specification Version 1.0” publication addresses those changes and provides continued guidance towards a nationally consistent lidar dataset.

  19. IDC System Specification Document.

    SciTech Connect

    Clifford, David J.

    2014-12-01

    This document contains the system specifications derived to satisfy the system requirements found in the IDC System Requirements Document for the IDC Reengineering Phase 2 project. Revisions Version Date Author/Team Revision Description Authorized by V1.0 12/2014 IDC Reengineering Project Team Initial delivery M. Harris

  20. Specifications for Thesaurus Software.

    ERIC Educational Resources Information Center

    Milstead, Jessica L.

    1991-01-01

    Presents specifications for software that is designed to support manual development and maintenance of information retrieval thesauri. Evaluation of existing software and design of custom software is discussed, requirements for integration with larger systems and for the user interface are described, and relationships among terms are discussed.…

  1. Facilities Specifications Guide.

    ERIC Educational Resources Information Center

    Athletic Business, 2000

    2000-01-01

    Provides line drawings of indoor and outdoor sporting fields reflecting the specifications and dimensional standards of each, including where additional information can be found. Sporting events from badminton, baseball, and basketball to lacrosse, swimming/diving, and volleyball are addressed. (GR)

  2. Sport-specific balance.

    PubMed

    Zemková, Erika

    2014-05-01

    This review includes the latest findings based on experimental studies addressing sport-specific balance, an area of research that has grown dramatically in recent years. The main objectives of this work were to investigate the postural sway response to different forms of exercise under laboratory and sport-specific conditions, to examine how this effect can vary with expertise, and to provide examples of the association of impaired balance with sport performance and/or increasing risk of injury. In doing so, sports where body balance is one of the limiting factors of performance were analyzed. While there are no significant differences in postural stability between athletes of different specializations and physically active individuals during standing in a standard upright position (e.g., bipedal stance), they have a better ability to maintain balance in specific conditions (e.g., while standing on a narrow area of support). Differences in magnitude of balance impairment after specific exercises (rebound jumps, repeated rotations, etc.) and mainly in speed of its readjustment to baseline are also observed. Besides some evidence on an association of greater postural sway with the increasing risk of injuries, there are many myths related to the negative influence of impaired balance on sport performance. Though this may be true for shooting or archery, findings have shown that in many other sports, highly skilled athletes are able to perform successfully in spite of increased postural sway. These findings may contribute to better understanding of the postural control system under various performance requirements. It may provide useful knowledge for designing training programs for specific sports.

  3. Referral Directory System Specification

    DTIC Science & Technology

    1990-03-30

    Centel I Wildemuth , Barbara ERIC Clearinghouse on Tests, Measurement al I Wilhoit, R. C. ITexas Engineering Experiment Station, Ther I Williams, Larry...Donald J. 990538 DEFENSE GATEWAY INFORMATION SYSTEM SYSTEM SPECIFICATION APPENDIX D: SAMPLE INDICES 69 W Wilde, D. U. 991983 Wildemuth , Barbara ...Wente, Van A. 991660 Werk, William R. 990806 Zaker, T. A. 991295 Wert, Barbara 990620 Zeidlik, Hannah 990758 West, Oriana Brown 990825 Zeller, M

  4. NOSS altimeter algorithm specifications

    NASA Technical Reports Server (NTRS)

    Hancock, D. W.; Forsythe, R. G.; Mcmillan, J. D.

    1982-01-01

    A description of all algorithms required for altimeter processing is given. Each description includes title, description, inputs/outputs, general algebraic sequences and data volume. All required input/output data files are described and the computer resources required for the entire altimeter processing system were estimated. The majority of the data processing requirements for any radar altimeter of the Seasat-1 type are scoped. Additions and deletions could be made for the specific altimeter products required by other projects.

  5. SPECIFIC HEAT INDICATOR

    DOEpatents

    Horn, F.L.; Binns, J.E.

    1961-05-01

    Apparatus for continuously and automatically measuring and computing the specific heat of a flowing solution is described. The invention provides for the continuous measurement of all the parameters required for the mathematical solution of this characteristic. The parameters are converted to logarithmic functions which are added and subtracted in accordance with the solution and a null-seeking servo reduces errors due to changing voltage drops to a minimum. Logarithmic potentiometers are utilized in a unique manner to accomplish these results.

  6. Component-specific modeling

    NASA Technical Reports Server (NTRS)

    Mcknight, R. L.

    1985-01-01

    Accomplishments are described for the second year effort of a 3-year program to develop methodology for component specific modeling of aircraft engine hot section components (turbine blades, turbine vanes, and burner liners). These accomplishments include: (1) engine thermodynamic and mission models; (2) geometry model generators; (3) remeshing; (4) specialty 3-D inelastic stuctural analysis; (5) computationally efficient solvers, (6) adaptive solution strategies; (7) engine performance parameters/component response variables decomposition and synthesis; (8) integrated software architecture and development, and (9) validation cases for software developed.

  7. 310 Facility chemical specifications

    SciTech Connect

    Hagerty, K.J.

    1997-05-21

    The 300 area Treated Effluent Disposal Facility (TEDF) was designed and built to treat the waste water from the 300 area process sewer system. Several treatment technologies are employed to remove the trace quantities of contaminants in the stream, including iron coprecipitation, clarification, filtration, ion exchange, and ultra violet light/hydrogen peroxide oxidation of organics. The chemicals that will be utilized in the treatment process are hydrogen peroxide, sulfuric acid, sodium hydroxide, and ferric chloride. This document annotates the required chemical characteristics of TEDF bulk chemicals as well as the criteria that were used to establish these criteria. The chemical specifications in appendix B are generated from this information.

  8. General Environmental Verification Specification

    NASA Technical Reports Server (NTRS)

    Milne, J. Scott, Jr.; Kaufman, Daniel S.

    2003-01-01

    The NASA Goddard Space Flight Center s General Environmental Verification Specification (GEVS) for STS and ELV Payloads, Subsystems, and Components is currently being revised based on lessons learned from GSFC engineering and flight assurance. The GEVS has been used by Goddard flight projects for the past 17 years as a baseline from which to tailor their environmental test programs. A summary of the requirements and updates are presented along with the rationale behind the changes. The major test areas covered by the GEVS include mechanical, thermal, and EMC, as well as more general requirements for planning, tracking of the verification programs.

  9. Master Software Requirements Specification

    NASA Technical Reports Server (NTRS)

    Hu, Chaumin

    2003-01-01

    A basic function of a computational grid such as the NASA Information Power Grid (IPG) is to allow users to execute applications on remote computer systems. The Globus Resource Allocation Manager (GRAM) provides this functionality in the IPG and many other grids at this time. While the functionality provided by GRAM clients is adequate, GRAM does not support useful features such as staging several sets of files, running more than one executable in a single job submission, and maintaining historical information about execution operations. This specification is intended to provide the environmental and software functional requirements for the IPG Job Manager V2.0 being developed by AMTI for NASA.

  10. Specifications Physiological Monitoring System

    NASA Technical Reports Server (NTRS)

    1985-01-01

    The operation of a physiological monitoring system (PMS) is described. Specifications were established for performance, design, interface, and test requirements. The PMS is a compact, microprocessor-based system, which can be worn in a pack on the body or may be mounted on a Spacelab rack or other appropriate structure. It consists of two modules, the Data Control Unit (DCU) and the Remote Control/Display Unit (RCDU). Its purpose is to collect and distribute data from physiological experiments in the Spacelab and in the Orbiter.

  11. Component-specific modeling

    NASA Technical Reports Server (NTRS)

    Mcknight, R. L.

    1985-01-01

    A series of interdisciplinary modeling and analysis techniques that were specialized to address three specific hot section components are presented. These techniques will incorporate data as well as theoretical methods from many diverse areas including cycle and performance analysis, heat transfer analysis, linear and nonlinear stress analysis, and mission analysis. Building on the proven techniques already available in these fields, the new methods developed will be integrated into computer codes to provide an accurate, and unified approach to analyzing combustor burner liners, hollow air cooled turbine blades, and air cooled turbine vanes. For these components, the methods developed will predict temperature, deformation, stress and strain histories throughout a complete flight mission.

  12. Specific construction tests

    NASA Technical Reports Server (NTRS)

    Mcrae, W. V., Jr.

    1980-01-01

    The technical feasibility of the Satellite Power System (SPS) is discussed. The development of feasible operational concepts and conceptualization of specific construction tasks are examined. The logic flow of functional analyses of both the rectenna and the satellite is illustrated. Constraints placed upon the construction processes and equipment by the satellite design are outlined. The construction tasks, when defined and combined into an integrated schedule establish, a time line for construction mass flow demands to be satisfied by the space transportation systems. An example of satellite constructive demands and HLLV delivery capabilities is given.

  13. Dyslexia (specific reading disability).

    PubMed

    Shaywitz, Sally E; Shaywitz, Bennett A

    2005-06-01

    Converging evidence from a number of lines of investigation indicates that dyslexia represents a disorder within the language system and more specifically within a particular subcomponent of that system, phonological processing. Recent advances in imaging technology, particularly the development of functional magnetic resonance imaging, provide evidence of a neurobiological signature for dyslexia, specifically a disruption of two left hemisphere posterior brain systems, one parieto-temporal, the other occipito-temporal, with compensatory engagement of anterior systems around the inferior frontal gyrus and a posterior (right occipito-temporal) system. Furthermore, good evidence indicates a computational role for the left occipito-temporal system: the development of fluent (automatic) reading. The brain systems for reading are malleable and their disruption in dyslexic children may be remediated by provision of an evidence-based, effective reading intervention. In addition, functional magnetic resonance imaging studies of young adults with reading difficulties followed prospectively and longitudinally from age 5 through their mid twenties suggests that there may be two types of reading difficulties, one primarily on a genetic basis, the other, and far more common, reflecting environmental influences. These studies offer the promise for more precise identification and effective management of dyslexia in children, adolescents and adults.

  14. Disease specific protein corona

    NASA Astrophysics Data System (ADS)

    Rahman, M.; Mahmoudi, M.

    2015-03-01

    It is now well accepted that upon their entrance into the biological environments, the surface of nanomaterials would be covered by various biomacromolecules (e.g., proteins and lipids). The absorption of these biomolecules, so called `protein corona', onto the surface of (nano)biomaterials confers them a new `biological identity'. Although the formation of protein coronas on the surface of nanoparticles has been widely investigated, there are few reports on the effect of various diseases on the biological identity of nanoparticles. As the type of diseases may tremendously changes the composition of the protein source (e.g., human plasma/serum), one can expect that amount and composition of associated proteins in the corona composition may be varied, in disease type manner. Here, we show that corona coated silica and polystyrene nanoparticles (after interaction with in the plasma of the healthy individuals) could induce unfolding of fibrinogen, which promotes release of the inflammatory cytokines. However, no considerable releases of inflammatory cytokines were observed for corona coated graphene sheets. In contrast, the obtained corona coated silica and polystyrene nanoparticles from the hypofibrinogenemia patients could not induce inflammatory cytokine release where graphene sheets do. Therefore, one can expect that disease-specific protein coronas can provide a novel approach for applying nanomedicine to personalized medicine, improving diagnosis and treatment of different diseases tailored to the specific conditions and circumstances.

  15. VOST charcoal specification study

    SciTech Connect

    Fuerst, R.G.; Foster, A.L.; Bursey, J.T.

    1996-12-31

    The volatile organic sampling train (VOST) is currently one the leading methodologies available for the sampling and analysis of volatile principal organic hazardous constituents (POHCs) and products of incomplete combustion (PICs) from stationary sources at very low levels. However, revisions to the original method are necessary to maintain VOST as a viable regulatory tool. To provide performance specifications and identify a replacement for SKC Lot 104 charcoal, a VOST charcoal specification study was initiated. The following carbon-based candidate sorbents were considered: Tenax-GR (a graphitized Tenax); a Petroleum-based Charcoal; Ambersorbe XE-340 (hydrophobic carbonized resin bead); Anasorb 747 (beaded active carbon with very regular pore size); Carbosieve{reg_sign} S-III (carbon molecular sieve); and a Beaded Activated Charcoal (BAC) (with a very regular pore size). The results indicated that Tenax-GR showed significantly poorer performance than the other candidates in preliminary experimental results. Ambersorb did not retain the gaseous volatile organic compounds tested as well as the others and recovery of vinyl chloride was very low at all levels of spiking. Carbosieve was eliminated as a candidate replacement because of cost and handling problems. The petroleum-based charcoal was eliminated because of difficulties in handling a finely-divided powder. The availability of Anasorb 747 proved to be the deciding factor between it and the BAC. Performance, cost, ease of handling, and plentiful supply make Anasorb{reg_sign} 747 a good choice for replacement of SKC Lot 104. 1 tab.

  16. Component-specific modeling

    NASA Technical Reports Server (NTRS)

    Mcknight, R. L.

    1984-01-01

    A series of interdisciplinary modeling and analysis techniques that were specialized to address three specific hot section components are presented. These techniques will incorporate data as well as theoretical methods from many diverse areas including cycle and performance analysis, heat transfer analysis, linear and nonlinear stress analysis, and mission analysis. Building on the proven techniques already available in these fields, the new methods developed will be integrated into computer codes to provide an accurate, efficient and unified approach to analyzing combustor burner liners, hollow air-cooled turbine blades and air-cooled turbine vanes. For these components, the methods developed will predict temperature, deformation, stress and strain histories throughout a complete flight mission.

  17. Component specific modeling

    NASA Technical Reports Server (NTRS)

    Maffeo, R. J.; Mcknight, R. L.; Tipton, M. T.; Weber, G.

    1986-01-01

    The overall objective of this program is to develop and verify a series of interdisciplinary modeling and analysis techniques that were specialized to address three specific hot section components. These techniques incorporate data as well as theoretical methods from many diverse areas including cycle and performance analysis, heat transfer analysis, linear and nonlinear stress analysis, and mission analysis. Building on the proven techniques already available in these fields, the new methods developed are integrated to provide an accurate, efficient, and unified approach to analyzing combustor burner liners, hollow air-cooled turbine blades, and air-cooled turbine vanes. For these components, the methods developed predict temperature, deformation, stress, and strain histories throughout a complete flight mission.

  18. The Void Specification

    SciTech Connect

    Cook, B

    2005-04-23

    The purpose of this memo is to explore more fully the allowable void specification, in part to make it clearer to those doing the day-to-day evaluation and in part to help me understand the ramifications. A simulation of voids in a Be shell is used to support my understanding of Haan's analysis. The key results showing allowable void diameter as a function of void fraction are shown in Figure 6 (p. 8). What is important here is that generally in ''good'' samples we only see small voids, perhaps at most a few tenths of a {micro}m in size. For this void size the shells can be underdense by as much as 10% and still meet the 1 part in 10{sup 4} spec (though there may be other issues with reduced density).

  19. Intent Specifications: An Approach to Building Human-Centered Specifications

    NASA Technical Reports Server (NTRS)

    Leveson, Nancy G.

    1999-01-01

    This paper examines and proposes an approach to writing software specifications, based on research in systems theory, cognitive psychology, and human-machine interaction. The goal is to provide specifications that support human problem solving and the tasks that humans must perform in software development and evolution. A type of specification, called intent specifications, is constructed upon this underlying foundation.

  20. Specific immunotherapy in children.

    PubMed

    Bufe, A; Roberts, G

    2011-09-01

    Subcutaneous immunotherapy (SCIT) with allergen extracts in children with allergic rhinitis, with or without co-seasonal asthma, has developed into a routine treatment although the scientific evidence for its efficacy is not as strong as for adults. In the hands of experienced allergists, this treatment has been proven to be safe. The development of allergen tablets for sublingual immunotherapy (SLIT) may open a new age of more convenient, safer SIT. In children, in particular, the evidence for the long-term efficacy of SLIT, its ability to prevent the development of asthma and polysensitization and its comparability to SCIT will be required before it will replace the traditional subcutaneous route. Issues of compliance represent an important drawback of SLIT. We need ways of improving this. Treatment of asthma by immunotherapy is still restricted to clearly defined patients with mild to moderate asthma with symptoms that are related to the specific allergen sensitization. In these patients, symptoms and use of anti-inflammatory therapy can be reduced by SIT.

  1. ADANS database specification

    SciTech Connect

    1997-01-16

    The purpose of the Air Mobility Command (AMC) Deployment Analysis System (ADANS) Database Specification (DS) is to describe the database organization and storage allocation and to provide the detailed data model of the physical design and information necessary for the construction of the parts of the database (e.g., tables, indexes, rules, defaults). The DS includes entity relationship diagrams, table and field definitions, reports on other database objects, and a description of the ADANS data dictionary. ADANS is the automated system used by Headquarters AMC and the Tanker Airlift Control Center (TACC) for airlift planning and scheduling of peacetime and contingency operations as well as for deliberate planning. ADANS also supports planning and scheduling of Air Refueling Events by the TACC and the unit-level tanker schedulers. ADANS receives input in the form of movement requirements and air refueling requests. It provides a suite of tools for planners to manipulate these requirements/requests against mobility assets and to develop, analyze, and distribute schedules. Analysis tools are provided for assessing the products of the scheduling subsystems, and editing capabilities support the refinement of schedules. A reporting capability provides formatted screen, print, and/or file outputs of various standard reports. An interface subsystem handles message traffic to and from external systems. The database is an integral part of the functionality summarized above.

  2. [Foot specific orthotic devices].

    PubMed

    Goldcher, Alain

    2010-03-20

    For each foot pathology, whatever its nature and aetiology, there is an orthesis, the best mechanical treatment. For toe pathologies due to or worsened by the footwear, we must recommend wearing other shoes and sometimes an orthoplasty which is not covered by health insurance. Sole orthesis are quite effective for most pathologies causing pain when walking, and involving the foot sole or starting in the foot. Realised by an approved splint technician, they are covered by health insurance for a lump sum, but patients are telling us their cost is becoming more and more difficult to bear Mass-produced shoes, therapeutic or not, deserve a special place in the therapeutic arsenal of podiatry. Temporary used shoes improve post-operation situation and some specifically located discharges. More and more shoes are available for longer use, most of them not approved but better looking, and at least as effective as and not costlier than the few models covered by health insurance.They can provide footwear that are not standard and can't be helped by bespoke shoes reserved for precise medical indications.

  3. Genotype Specification Language.

    PubMed

    Wilson, Erin H; Sagawa, Shiori; Weis, James W; Schubert, Max G; Bissell, Michael; Hawthorne, Brian; Reeves, Christopher D; Dean, Jed; Platt, Darren

    2016-06-17

    We describe here the Genotype Specification Language (GSL), a language that facilitates the rapid design of large and complex DNA constructs used to engineer genomes. The GSL compiler implements a high-level language based on traditional genetic notation, as well as a set of low-level DNA manipulation primitives. The language allows facile incorporation of parts from a library of cloned DNA constructs and from the "natural" library of parts in fully sequenced and annotated genomes. GSL was designed to engage genetic engineers in their native language while providing a framework for higher level abstract tooling. To this end we define four language levels, Level 0 (literal DNA sequence) through Level 3, with increasing abstraction of part selection and construction paths. GSL targets an intermediate language based on DNA slices that translates efficiently into a wide range of final output formats, such as FASTA and GenBank, and includes formats that specify instructions and materials such as oligonucleotide primers to allow the physical construction of the GSL designs by individual strain engineers or an automated DNA assembly core facility.

  4. Specificity and non-specificity in RNA–protein interactions

    PubMed Central

    Jankowsky, Eckhard; Harris, Michael E.

    2016-01-01

    Gene expression is regulated by complex networks of interactions between RNAs and proteins. Proteins that interact with RNA have been traditionally viewed as either specific or non-specific; specific proteins interact preferentially with defined RNA sequence or structure motifs, whereas non-specific proteins interact with RNA sites devoid of such characteristics. Recent studies indicate that the binary “specific vs. non-specific” classification is insufficient to describe the full spectrum of RNA–protein interactions. Here, we review new methods that enable quantitative measurements of protein binding to large numbers of RNA variants, and the concepts aimed as describing resulting binding spectra: affinity distributions, comprehensive binding models and free energy landscapes. We discuss how these new methodologies and associated concepts enable work towards inclusive, quantitative models for specific and non-specific RNA–protein interactions. PMID:26285679

  5. Variola virus-specific diagnostic assays: characterization, sensitivity, and specificity.

    PubMed

    Kondas, Ashley V; Olson, Victoria A; Li, Yu; Abel, Jason; Laker, Miriam; Rose, Laura; Wilkins, Kimberly; Turner, Jonathan; Kline, Richard; Damon, Inger K

    2015-04-01

    A public health response relies upon rapid and reliable confirmation of disease by diagnostic assays. Here, we detail the design and validation of two variola virus-specific real-time PCR assays, since previous assays cross-reacted with newly identified cowpox viruses. The assay specificity must continually be reassessed as other closely related viruses are identified.

  6. SPECIFIC AND NON-SPECIFIC POLYSACCHARIDES OF TYPE IV PNEUMOCOCCUS

    PubMed Central

    Heidelberger, Michael; Kendall, Forrest E.

    1931-01-01

    1. Three nitrogen-containing polysaccharides have been isolated from autolyzed cultures of Type IV pneumococcus: (1) a type-specific carbohydrate differing markedly from those of Type I, II, and III pneumococcus, and representing a type of substance hitherto not observed among specific polysaccharides, (2) a chemically similar carbohydrate without specific function, and (3) the "C" substance, or species-specific polysaccharide of Tillett, Goebel, and Avery. 2. The chemical differences between the specific polysaccharides of Pneumococcus are discussed, and the relationship of the new examples to chitin is pointed out and its bearing indicated on the unsettled controversy as to whether or not chitin occurs in bacteria. 3. The data of Tillett, Goebel, and Avery on the "C" substance have been extended. PMID:19869869

  7. [Multilingualism and specific language impairment].

    PubMed

    Arkkila, Eva; Smolander, Sini; Laasonen, Marja

    2013-01-01

    Specific language impairment is one of the most common developmental disturbances in childhood. With the increase of the foreign language population group an increasing number of children assimilating several languages and causing concern in language development attend clinical examinations. Knowledge of factors underlying the specific language impairment and the specific impairment in general, special features of language development of those learning several languages, as well as the assessment and support of the linguistic skills of a multilingual child is essential. The risk of long-term problems and marginalization is high for children having specific language impairment.

  8. Specific Learning Difficulties in Mathematics.

    ERIC Educational Resources Information Center

    Weedon, Charles

    Specific difficulties in mathematics tend to receive much less attention than do parallel difficulties with language. Accordingly, as its contribution to an ongoing project on children's learning difficulties and what to do about them, the Tayside (Scotland) Region decided to focus on children's specific problems with mathematics/arithmetic and…

  9. Performance Specifications for Occupational Programs.

    ERIC Educational Resources Information Center

    Maryland State Dept. of Education, Baltimore. Div. of Career Technology and Adult Learning.

    This document lists and discusses the development of Maryland's performance specifications for occupational programs. The introduction explains the process used to develop performance standards and specifications for 10 career cluster majors that were identified by a task force of educators and employers as high-demand occupational areas in…

  10. Hanford Site environmental management specification

    SciTech Connect

    Grygiel, M.L.

    1998-06-10

    The US Department of Energy, Richland Operations Office (RL) uses this Hanford Site Environmental Management Specification (Specification) to document top-level mission requirements and planning assumptions for the prime contractors involved in Hanford Site cleanup and infrastructure activities under the responsibility of the US Department of Energy, Office of Environmental Management. This Specification describes at a top level the activities, facilities, and infrastructure necessary to accomplish the cleanup of the Hanford Site and assigns this scope to Site contractors and their respective projects. This Specification also references the key National Environmental Policy Act of 1969 (NEPA), Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA), and safety documentation necessary to accurately describe the cleanup at a summary level. The information contained in this document reflects RL`s application of values, priorities, and critical success factors expressed by those involved with and affected by the Hanford Site project. The prime contractors and their projects develop complete baselines and work plans to implement this Specification. These lower-level documents and the data that support them, together with this Specification, represent the full set of requirements applicable to the contractors and their projects. Figure 1-1 shows the relationship of this Specification to the other basic Site documents. Similarly, the documents, orders, and laws referenced in this specification represent only the most salient sources of requirements. Current and contractual reference data contain a complete set of source documents.

  11. The Development of Educational Specifications.

    ERIC Educational Resources Information Center

    North Carolina State Board of Education, Raleigh.

    This publication is intended to assist local boards of education, superintendents, and staff in the organization and development of educational specifications. It was written because most educators have little knowledge about the purpose, process, organization, or contents of the finished product (educational specifications). It provides a…

  12. PROPOSED SPECIFICATIONS FOR INERTIAL SURVEYING.

    USGS Publications Warehouse

    Chapman, William H.

    1983-01-01

    The purpose of this paper is to continue the movement toward placing inertial surveying instruments in the toolbox of the geodetic surveyor. A set of specifications is proposed for performing horizontal geodetic surveys with inertial instruments that will meet the Federal Geodetic Control Committee (FGCC) second- and third-order standards. These specifications are tentative.

  13. Suggestions for Developing Educational Specifications.

    ERIC Educational Resources Information Center

    Kansas State Dept. of Public Instruction, Topeka.

    In the preparation of written educational specifications, the content, organization and method of presentation of materials are far from standardized with no one pattern being advocated. There are, however, certain standards or criteria which are desirable for guidance. The educational specifications should provide the architect with all of the…

  14. Response to "Transfer or Specificity?"

    ERIC Educational Resources Information Center

    Miller, Judith

    2007-01-01

    This article presents the author's response to "Transfer or Specificity?" and reports a research that supports a strong case for a fundamental motor skill as a precursor to two sport specific skills as in Gallahue and Ozmun's (2002) theoretical model of motor development. Reported changes in performance of the overarm throw are…

  15. Specificity of Exercise and Specificity of Training: A Subcellular Review

    ERIC Educational Resources Information Center

    McCafferty, William B.; Horvath, Steven M.

    1977-01-01

    Selection of proper competitive activities for athletes is discussed in relation to the acknowledged fact that cellular adaptation is dependent upon the specific program employed in training for competitive events. (MB)

  16. Standard technical specifications, Westinghouse Plants: Specifications. Volume 1, Revision 1

    SciTech Connect

    1995-04-01

    This NUREG contains the improved Standard Technical Specifications (STS) for Westinghouse plants. Revision 1 incorporates the cumulative changes to Revision 0, which was published in September 1992. The changes reflected in Revision 1 resulted from the experience gained from license amendment applications to convert to these improved STS or to adopt partial improvements to existing technical specifications. This NUREG is the result of extensive public technical meetings and discussions between the Nuclear Regulatory Commission (NRC) staff and various nuclear power plant licensees, Nuclear Steam Supply System (NSSS) Owners Groups, specifically the Westinghouse Owners Group (WOG), NSSS vendors, and the Nuclear Energy Institute (NEI). The improved STS were developed based on the criteria in the Final Commission Policy Statement on Technical Specifications Improvements for Nuclear Power Reactors, dated July 22, 1993 (58 FR 39132). Licensees are encouraged to upgrade their technical specifications consistent with those criteria and conforming, to the extent practical and consistent with the licensing basis for the facility, to Revision 1 to the improved STS. The Commission continues to place the highest priority on requests for complete conversions to the improved STS. Licensees adopting portions of the improved STS to existing technical specifications should adopt all related requirements, as applicable, to achieve a high degree of standardization and consistency.

  17. Information capacity of specific interactions

    PubMed Central

    Huntley, Miriam H.; Murugan, Arvind; Brenner, Michael P.

    2016-01-01

    Specific interactions are a hallmark feature of self-assembly and signal-processing systems in both synthetic and biological settings. Specificity between components may arise from a wide variety of physical and chemical mechanisms in diverse contexts, from DNA hybridization to shape-sensitive depletion interactions. Despite this diversity, all systems that rely on interaction specificity operate under the constraint that increasing the number of distinct components inevitably increases off-target binding. Here we introduce “capacity,” the maximal information encodable using specific interactions, to compare specificity across diverse experimental systems and to compute how specificity changes with physical parameters. Using this framework, we find that “shape” coding of interactions has higher capacity than chemical (“color”) coding because the strength of off-target binding is strongly sublinear in binding-site size for shapes while being linear for colors. We also find that different specificity mechanisms, such as shape and color, can be combined in a synergistic manner, giving a capacity greater than the sum of the parts. PMID:27155013

  18. SSL: A software specification language

    NASA Technical Reports Server (NTRS)

    Austin, S. L.; Buckles, B. P.; Ryan, J. P.

    1976-01-01

    SSL (Software Specification Language) is a new formalism for the definition of specifications for software systems. The language provides a linear format for the representation of the information normally displayed in a two-dimensional module inter-dependency diagram. In comparing SSL to FORTRAN or ALGOL, it is found to be largely complementary to the algorithmic (procedural) languages. SSL is capable of representing explicitly module interconnections and global data flow, information which is deeply imbedded in the algorithmic languages. On the other hand, SSL is not designed to depict the control flow within modules. The SSL level of software design explicitly depicts intermodule data flow as a functional specification.

  19. Grade 6 Science Curriculum Specifications.

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Curriculum Branch.

    This material describes curriculum specifications for grade 6 science in Alberta. Emphases recommended are: (1) process skills (50%); (2) psychomotor skills (10%); (3) attitudes (10%); and (4) subject matter (30%). Priorities within each category are identified. (YP)

  20. Molecular Mechanisms of Synaptic Specificity

    PubMed Central

    Margeta, Milica A.; Shen, Kang

    2011-01-01

    Synapses are specialized junctions that mediate information flow between neurons and their targets. A striking feature of the nervous system is the specificity of its synaptic connections: an individual neuron will form synapses only with a small subset of available presynaptic and postsynaptic partners. Synaptic specificity has been classically thought to arise from homophilic or heterophilic interactions between adhesive molecules acting across the synaptic cleft. Over the past decade, many new mechanisms giving rise to synaptic specificity have been identified. Synapses can be specified by secreted molecules that promote or inhibit synaptogenesis, and their source can be a neighboring guidepost cell, not just presynaptic and postsynaptic neurons. Furthermore, lineage, fate, and timing of development can also play critical roles in shaping neural circuits. Future work utilizing large-scale screens will aim to elucidate the full scope of cellular mechanisms and molecular players that can give rise to synaptic specificity. PMID:19969086

  1. GFF Specification for SAR Systems

    SciTech Connect

    Sweet, Nathan; Bielek, Timothy P.; Matthews, John D.; Coakley, Henry John; Pan, Len

    2014-08-01

    This document provides the basic GFF format definition for a GFF file. This document covers the contents of the main header and the basic GFF file structure. The contents of specific extensions are covered in a separate document.

  2. Electric motor model repair specifications

    SciTech Connect

    1995-08-01

    These model repair specifications list the minimum requirements for repair and overhaul of polyphase AC squireel cage induction motors. All power ranges, voltages, and speeds of squirrel cage motors are covered.

  3. NEW STEEL AND ALLOY SPECIFICATIONS

    DTIC Science & Technology

    Research Institute of Ferrous Metalurgy , USSR. The minimum tensile strengths and elongations (in percent) are indicated for 12 of the specifications; in some cases the chemical composition is also indicated.

  4. Expression specificity of GFAP transgenes.

    PubMed

    Su, Mu; Hu, Huimin; Lee, Youngjin; d'Azzo, Alessandra; Messing, Albee; Brenner, Michael

    2004-11-01

    Glial fibrillary acidic protein (GFAP) is an intermediate filament protein found predominantly in astrocytes. This specificity has recommended the GFAP gene promoter for targeting transgene expression to astrocytes. Although both we [Brenner et al. J. Neurosci. 14:1030-1037, (1994)] and others [Mucke et al. New Biol. 3:465-474, (1991)] have reported astrocyte specificity for GFAP promoters, we demonstrate here that these DNA sequences can also direct activity in neurons. The pattern of neuronal activity varied with both the nature of the expressed sequence and the transgene insertion site. Specifically, neuronal expression was very high for a protective protein/cathepsin A minigene, moderate for lacZ and undetectable for GFP. These findings, coupled with a survey of the literature, recommend that investigators using GFAP-driven transgenes verify specificity for each line studied, using a detection system whose sensitivity is sufficient to detect a compromising level of misexpression.

  5. Patient-Specific Orthopaedic Implants.

    PubMed

    Haglin, Jack M; Eltorai, Adam E M; Gil, Joseph A; Marcaccio, Stephen E; Botero-Hincapie, Juliana; Daniels, Alan H

    2016-11-01

    Patient-specific orthopaedic implants are emerging as a clinically promising treatment option for a growing number of conditions to better match an individual's anatomy. Patient-specific implant (PSI) technology aims to reduce overall procedural costs, minimize surgical time, and maximize patient outcomes by achieving better biomechanical implant fit. With this commercially-available technology, computed tomography or magnetic resonance images can be used in conjunction with specialized computer programs to create preoperative patient-specific surgical plans and to develop custom cutting guides from 3-D reconstructed images of patient anatomy. Surgeons can then place these temporary guides or "jigs" during the procedure, allowing them to better recreate the exact resections of the computer-generated surgical plan. Over the past decade, patient-specific implants have seen increased use in orthopaedics and they have been widely indicated in total knee arthroplasty, total hip arthroplasty, and corrective osteotomies. Patient-specific implants have also been explored for use in total shoulder arthroplasty and spinal surgery. Despite their increasing popularity, significant support for PSI use in orthopaedics has been lacking in the literature and it is currently uncertain whether the theoretical biomechanical advantages of patient-specific orthopaedic implants carry true advantages in surgical outcomes when compared to standard procedures. The purpose of this review was to assess the current status of patient-specific orthopaedic implants, to explore their future direction, and to summarize any comparative published studies that measure definitive surgical characteristics of patient-specific orthopaedic implant use such as patient outcomes, biomechanical implant alignment, surgical cost, patient blood loss, or patient recovery.

  6. mREST Interface Specification

    NASA Technical Reports Server (NTRS)

    McCartney, Patrick; MacLean, John

    2012-01-01

    mREST is an implementation of the REST architecture specific to the management and sharing of data in a system of logical elements. The purpose of this document is to clearly define the mREST interface protocol. The interface protocol covers all of the interaction between mREST clients and mREST servers. System-level requirements are not specifically addressed. In an mREST system, there are typically some backend interfaces between a Logical System Element (LSE) and the associated hardware/software system. For example, a network camera LSE would have a backend interface to the camera itself. These interfaces are specific to each type of LSE and are not covered in this document. There are also frontend interfaces that may exist in certain mREST manager applications. For example, an electronic procedure execution application may have a specialized interface for configuring the procedures. This interface would be application specific and outside of this document scope. mREST is intended to be a generic protocol which can be used in a wide variety of applications. A few scenarios are discussed to provide additional clarity but, in general, application-specific implementations of mREST are not specifically addressed. In short, this document is intended to provide all of the information necessary for an application developer to create mREST interface agents. This includes both mREST clients (mREST manager applications) and mREST servers (logical system elements, or LSEs).

  7. NIF optical specifications - the importance of the RMS gradient specification

    SciTech Connect

    Auerbach, J M; Cotton, C T; English, R E; Henesian, M A; Hunt J T; Kelly, J H; Lawson, J K; Sacks, J B; Shoup, M J; Trenholme, W H

    1998-07-06

    The performance of the National Ignition Facility (NIF), especially in terms of laser focusability, will be determined by several key factors. One of these key factors is the optical specification for the thousands of large aperture optics that will comprise the 192 beamlines. We have previously reported on the importance of the specification of the power spectral density (PSD) on NIF performance. Recently, we have been studying the importance of long spatial wavelength (>33 mm) phase errors on focusability. We have concluded that the preferred metric for determining the impact of these long spatial wavelength phase errors is the rms phase gradient. In this paper, we outline the overall approach to NIF optical specifications, detail the impact of the rms phase gradient on NIF focusability, discuss its trade-off with the PSD in determining the spot size and review measurements of optics similar to those to be manufactured for NIF.

  8. Quantifying group specificity of animal vocalizations without specific sender information

    NASA Astrophysics Data System (ADS)

    Vester, Heike; Hammerschmidt, Kurt; Timme, Marc; Hallerberg, Sarah

    2016-02-01

    Recordings of animal vocalization can lack information about sender and context. This is often the case in studies on marine mammals or in the increasing number of automated bioacoustics monitorings. Here, we develop a framework to estimate group specificity without specific sender information. We introduce and apply a bag-of-calls-and-coefficients approach (BOCCA) to study ensembles of cepstral coefficients calculated from vocalization signals recorded from a given animal group. Comparing distributions of such ensembles of coefficients by computing relative entropies reveals group specific differences. Applying the BOCCA to ensembles of calls recorded from group of long-finned pilot whales in northern Norway, we find that differences of vocalizations within social groups of pilot whales (Globicephala melas) are significantly lower than intergroup differences.

  9. Specificity of hammerhead ribozyme cleavage.

    PubMed Central

    Hertel, K J; Herschlag, D; Uhlenbeck, O C

    1996-01-01

    To be effective in gene inactivation, the hammerhead ribozyme must cleave a complementary RNA target without deleterious effects from cleaving non-target RNAs that contain mismatches and shorter stretches of complementarity. The specificity of hammerhead cleavage was evaluated using HH16, a well-characterized ribozyme designed to cleave a target of 17 residues. Under standard reaction conditions, HH16 is unable to discriminate between its full-length substrate and 3'-truncated substrates, even when six fewer base pairs are formed between HH16 and the substrate. This striking lack of specificity arises because all the substrates bind to the ribozyme with sufficient affinity so that cleavage occurs before their affinity differences are manifested. In contrast, HH16 does exhibit high specificity towards certain 3'-truncated versions of altered substrates that either also contain a single base mismatch or are shortened at the 5' end. In addition, the specificity of HH16 is improved in the presence of p7 nucleocapsid protein from human immunodeficiency virus (HIV)-1, which accelerates the association and dissociation of RNA helices. These results support the view that the hammerhead has an intrinsic ability to discriminate against incorrect bases, but emphasizes that the high specificity is only observed in a certain range of helix lengths. Images PMID:8670879

  10. Technical specification for vacuum systems

    SciTech Connect

    Khaw, J.

    1987-01-01

    The vacuum systems at the Stanford Linear Accelerator Center (SLAC) are primarily of all-metal construction and operate at pressures from 10/sup -5/ to 10/sup -11/ Torr. The primary gas loads during operation result from thermal desorption and beam-induced desorption from the vacuum chamber walls. These desorption rates can be extremely high in the case of hydrocarbons and other contaminants. These specifications place a major emphasis on eliminating contamination sources. The specifications and procedures have been written to insure the cleanliness and vacuum integrity of all SLAC vacuum systems, and to assist personnel involved with SLAC vacuum systems in choosing and designing components that are compatible with existing systems and meet the quality and reliability of SLAC vacuum standards. The specification includes requirements on design, procurement, fabrication, chemical cleaning, clean room practices, welding and brazing, helium leak testing, residual gas analyzer testing, bakeout, venting, and pumpdown. Also appended are specifications regarding acceptable vendors, isopropyl alcohol, bakeable valve cleaning procedure, mechanical engineering safety inspection, notes on synchrotron radiation, and specifications of numerous individual components. (LEW)

  11. 1997 hybrid electric vehicle specifications

    SciTech Connect

    Sluder, S.; Larsen, R.; Duoba, M.

    1996-10-01

    The US DOE sponsors Advanced Vehicle Technology competitions to help educate the public and advance new vehicle technologies. For several years, DOE has provided financial and technical support for the American Tour de Sol. This event showcases electric and hybrid electric vehicles in a road rally across portions of the northeastern United States. The specifications contained in this technical memorandum apply to vehicles that will be entered in the 1997 American Tour de Sol. However, the specifications were prepared to be general enough for use by other teams and individuals interested in developing hybrid electric vehicles. The purpose of the specifications is to ensure that the vehicles developed do not present a safety hazard to the teams that build and drive them or to the judges, sponsors, or public who attend the competitions. The specifications are by no means the definitive sources of information on constructing hybrid electric vehicles - as electric and hybrid vehicles technologies advance, so will the standards and practices for their construction. In some cases, the new standards and practices will make portions of these specifications obsolete.

  12. Compiler writing system detail design specification. Volume 1: Language specification

    NASA Technical Reports Server (NTRS)

    Arthur, W. J.

    1974-01-01

    Construction within the Meta language for both language and target machine specification is reported. The elements of the function language as a meaning and syntax are presented, and the structure of the target language is described which represents the target dependent object text representation of applications programs.

  13. Standard specification for ASTM thermometers

    SciTech Connect

    Not Available

    1980-01-01

    Specifications are given for both solid-stem thermometers and enclosed scale thermometers. For the solid-stem thermometers, the specification covers liquid-in-glass thermometers graduated in Celsius (centigrade) or Fahrenheit degrees which are frequently specified in methods of the American Society for Testing and Materials. The various thermometers covered are listed. For enclosed-scale thermometers, the specification covers adjustable-range enclosed-scale thermometers, graduated in Celsius (centigrade) degrees, which are specified in methods of the American Society for Testing and Materials. These thermometers are commonly called Beckmann thermometers, and are suitable for measuring small temperature differences not exceeding 6/sup 0/C within a larger range of temperature. The thermometers, however, are unsuitable for measuring Celsius- or kelvin-scale temperatures unless they have been compared with standard instruments immediately before use.

  14. Application specific serial arithmetic arrays

    NASA Technical Reports Server (NTRS)

    Winters, K.; Mathews, D.; Thompson, T.

    1990-01-01

    High performance systolic arrays of serial-parallel multiplier elements may be rapidly constructed for specific applications by applying hardware description language techniques to a library of full-custom CMOS building blocks. Single clock pre-charged circuits have been implemented for these arrays at clock rates in excess of 100 Mhz using economical 2-micron (minimum feature size) CMOS processes, which may be quickly configured for a variety of applications. A number of application-specific arrays are presented, including a 2-D convolver for image processing, an integer polynomial solver, and a finite-field polynomial solver.

  15. High specific heat superconducting composite

    DOEpatents

    Steyert, Jr., William A.

    1979-01-01

    A composite superconductor formed from a high specific heat ceramic such as gadolinium oxide or gadolinium-aluminum oxide and a conventional metal conductor such as copper or aluminum which are insolubly mixed together to provide adiabatic stability in a superconducting mode of operation. The addition of a few percent of insoluble gadolinium-aluminum oxide powder or gadolinium oxide powder to copper, increases the measured specific heat of the composite by one to two orders of magnitude below the 5.degree. K. level while maintaining the high thermal and electrical conductivity of the conventional metal conductor.

  16. Host Specificity of Bacterial Pathogens

    PubMed Central

    Bäumler, Andreas; Fang, Ferric C.

    2013-01-01

    Most pathogens are able to infect multiple hosts but some are highly adapted to a single-host species. A detailed understanding of the basis of host specificity can provide important insights into molecular pathogenesis, the evolution of pathogenic microbes, and the potential for pathogens to cross the species barrier to infect new hosts. Comparative genomics and the development of humanized mouse models have provided important new tools with which to explore the basis of generalism and specialism. This review will examine host specificity of bacterial pathogens with a focus on generalist and specialist serovars of Salmonella enterica. PMID:24296346

  17. [Phenotype specific therapy of COPD].

    PubMed

    Rothe, Thomas

    2014-12-10

    COPD is not a homogenous disease but consists of at least four different phenotypes: Emphysema, COPD with chronic bronchitis, asthma-COPD overlap syndrome (ACOS), and COPD with recurrent exacerbations. With differentiation, treatment can be designed phenotype-specific. Some modern drugs are not indicated in all phenotypes.

  18. Netware-Specific Network Security.

    ERIC Educational Resources Information Center

    Snyder, Robin M.

    This paper focuses on practical and cost-effective NetWare-specific approaches to information systems and computer security. A series of real world experiences is presented that illustrate fundamental information systems and security concepts. A NetWare network is a client-server network which uses a file server to share files while client…

  19. [Specificities in children wound healing].

    PubMed

    Sanchez, J; Antonicelli, F; Tuton, D; Mazouz Dorval, S; François, C

    2016-10-01

    Children have specific characteristics of wound healing. The aim of this study was to describe the specific clinical characteristics of wounds healing in children and to present the current knowledge on the specific mechanisms with regard to infant age. The tissue insult or injury in fetus can heal without scar, mainly due to reduced granulation tissue associated to diminished or even no inflammatory phase, modified extracellular matrix such as the concentration of hyaluronic acid in amniotic liquid, expression and arrangement of collagen and tenascin. Thickness of children skin is a serious negative factor in case of trauma, whereas poor co-morbidities and efficient growth tissue mechanisms are beneficial to good evolution, even in cases of extensive damage and loss of tissue. The subsequent tissue mechanical forces, wound healing during childhood, spanning from the age of 2 until the end of puberty, is associated with more hypertrophic scars, both in duration and in intensity. Consequently, unnecessary surgery has to be avoided during this period when possible, and children with abnormal or pathologic wound healing should benefit from complementary treatments (hydration, massage, brace, silicone, hydrotherapy…), which represent efficient factors to minimize tissue scarring. After wound healing, the growth body rate can be responsible for specific complications, such as contractures, alopecia, and scar intussusceptions. Its evolutionary character implies the need of an attentive follow-up until adult age. Psychologic repercussions, as a consequence of pathologic scars, must be prevented and investigated by the surgeon.

  20. Developing dendrites demonstrate unexpected specificity.

    PubMed

    Chalupa, Leo M

    2006-11-22

    Our knowledge of how developing dendrites attain their mature state is still rudimentary. In this issue of Neuron, Mumm et al. rely on time-lapsed analysis of ingrowing dendrites of retinal ganglion cells in transgenic zebrafish to show that this process is much more specific than has been suspected.

  1. Specificity of Cardiovascular Endurance Training.

    ERIC Educational Resources Information Center

    Riley, Calberth B., Jr.; Johnson, James H.

    This study determined the specificity of cardiovascular endurance training on a bicycle ergometer. Eighteen male subjects were tested on a heart rate response test of 150 beats per minute on a bicycle ergometer at the pace of 50 revolutions per minute (rpm) and at 160 beats per minute at 60 and 80 rpm, with the resistance equal to the force of…

  2. Reflight certification software design specifications

    NASA Technical Reports Server (NTRS)

    1984-01-01

    The PDSS/IMC Software Design Specification for the Payload Development Support System (PDSS)/Image Motion Compensator (IMC) is contained. The PDSS/IMC is to be used for checkout and verification of the IMC flight hardware and software by NASA/MSFC.

  3. 46 CFR Sec. 3 - Specifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Specifications. Sec. 3 Section 3 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY PROCEDURE FOR ACCOMPLISHMENT OF VESSEL REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec....

  4. Portable File Format (PFF) specifications

    SciTech Connect

    Dolan, Daniel H.

    2015-02-01

    Created at Sandia National Laboratories, the Portable File Format (PFF) allows binary data transfer across computer platforms. Although this capability is supported by many other formats, PFF files are still in use at Sandia, particularly in pulsed power research. This report provides detailed PFF specifications for accessing data without relying on legacy code.

  5. Adaptive Assessments Using Open Specifications

    ERIC Educational Resources Information Center

    Leon, Hector Barbosa; Garcia-Penalvo, Francisco J.; Rodriguez-Conde, Maria Jose; Morales, Erla M.; de Pablos, Patricia Ordonez

    2012-01-01

    Evaluation is a key element in formal education processes; it must be constructed in a way that the item questions within help students understand by adapting them to the learning style as well. The focus of the present research work specifically in the convenience to adapt an associated multimedia material in each single question besides the…

  6. Frit specification development: Letter report

    SciTech Connect

    Smith, P.A.; Hrma, P.R.; Vienna, J.D.; Fini, P.T.

    1996-03-01

    To specify frit for the Hanford Waste Vitrification Plant (HWVP), the relevant requirements and characterization need to be established. The properties and applicable testing will be incorporated into a specification. Several areas have been identified that require consideration in a frit specification: glass processability and acceptability; frit storage and handling; frit slurry rheology; melter feed rheology; canister decontamination; pumping equipment/pipe erosion; frit cooling rate; and glass melting rate. The listed areas are influenced primarily by frit composition, temperature history, particle morphology, particle size, size distribution. and properties that depend on the primary variables such as hardness and frit density. Frit development proceeds in two steps: the first focuses on the waste glass, and the second on the pre-melt (including cold cap) processing.

  7. Isotope specific arbitrary material sorter

    SciTech Connect

    Barty, Christopher P.J.

    2015-12-08

    A laser-based mono-energetic gamma-ray source is used to provide a rapid and unique, isotope specific method for sorting materials. The objects to be sorted are passed on a conveyor in front of a MEGa-ray beam which has been tuned to the nuclear resonance fluorescence transition of the desired material. As the material containing the desired isotope traverses the beam, a reduction in the transmitted MEGa-ray beam occurs. Alternately, the laser-based mono-energetic gamma-ray source is used to provide non-destructive and non-intrusive, quantitative determination of the absolute amount of a specific isotope contained within pipe as part of a moving fluid or quasi-fluid material stream.

  8. Instrument specificity in experienced musicians.

    PubMed

    Drost, Ulrich C; Rieger, Martina; Prinz, Wolfgang

    2007-04-01

    Previous studies have shown that experienced pianists have acquired integrated action-effect (A-E) associations. In the present study, we were interested in how specific these associations are for the own instrument by investigating pianists and guitarists. A-E associations were examined by testing whether the perception of a "potential" action-effect has an influence on actions. Participants played chords on their instrument in response to visual stimuli, while they were presented task-irrelevant auditory distractors (congruent or incongruent) in varying instrument timbre. In Experiment 1, pianists exhibited an interference effect with timbres of their own instrument category (keyboard instruments: piano and organ). In Experiment 2 guitarists showed an interference effect only with guitar timbre. Thus, integrated A-E associations primarily seem to consist of a specific component on a sensory-motor level involving the own instrument. Additionally, categorical knowledge about how an instrument is played seems to be involved.

  9. Certifying Domain-Specific Policies

    NASA Technical Reports Server (NTRS)

    Lowry, Michael; Pressburger, Thomas; Rosu, Grigore; Koga, Dennis (Technical Monitor)

    2001-01-01

    Proof-checking code for compliance to safety policies potentially enables a product-oriented approach to certain aspects of software certification. To date, previous research has focused on generic, low-level programming-language properties such as memory type safety. In this paper we consider proof-checking higher-level domain -specific properties for compliance to safety policies. The paper first describes a framework related to abstract interpretation in which compliance to a class of certification policies can be efficiently calculated Membership equational logic is shown to provide a rich logic for carrying out such calculations, including partiality, for certification. The architecture for a domain-specific certifier is described, followed by an implemented case study. The case study considers consistency of abstract variable attributes in code that performs geometric calculations in Aerospace systems.

  10. Environmental Assessment (EA) for the Construction of the Commissary Addition at Eglin Air Force Base, Florida. Appendices

    DTIC Science & Technology

    1991-06-07

    Roof Felt - Downspout SE/Corner - Warehouse YES 16 M Roof Flashing - SE Corner - Warehouse ND ( asphalt shingles ) 17 M Roof Gauze - Joint of GSA...Bearing Ratio of 40 for a depth equal to the base thickness and should be compacted to a minimum of 95% of AASHTO T-180. The asphaltic concrete wearing...surface should consist of Type S-Ill asphaltic concrete meeting current Florida Department of Transportation specifications and placement procedures. A

  11. Lightweight Specifications for Parallel Correctness

    DTIC Science & Technology

    2012-12-05

    this burden, to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204... George Necula Professor David Wessel Fall 2012 1 Abstract Lightweight Specifications for Parallel Correctness by Jacob Samuels Burnim Doctor of Philosophy...enthusiasm and endless flow of ideas, and for his keen research sense. I would also like to thank George Necula for chairing my qualifying exam committee and

  12. Chromosome specific repetitive DNA sequences

    DOEpatents

    Moyzis, Robert K.; Meyne, Julianne

    1991-01-01

    A method is provided for determining specific nucleotide sequences useful in forming a probe which can identify specific chromosomes, preferably through in situ hybridization within the cell itself. In one embodiment, chromosome preferential nucleotide sequences are first determined from a library of recombinant DNA clones having families of repetitive sequences. Library clones are identified with a low homology with a sequence of repetitive DNA families to which the first clones respectively belong and variant sequences are then identified by selecting clones having a pattern of hybridization with genomic DNA dissimilar to the hybridization pattern shown by the respective families. In another embodiment, variant sequences are selected from a sequence of a known repetitive DNA family. The selected variant sequence is classified as chromosome specific, chromosome preferential, or chromosome nonspecific. Sequences which are classified as chromosome preferential are further sequenced and regions are identified having a low homology with other regions of the chromosome preferential sequence or with known sequences of other family me This invention is the result of a contract with the Department of Energy (Contract No. W-7405-ENG-36).

  13. Specific test and evaluation plan

    SciTech Connect

    Hays, W.H.

    1997-12-09

    The purpose of this Specific Test and Evaluation Plan (STEP) is to provide a detailed written plan for the systematic testing of modifications made to the 241-AN-A Valve Pit by the W-314 Project. The STEP develops the outline for test procedures that verify the system`s performance to the established Project design criteria. The STEP is a ``lower tier`` document based on the W-314 Test and Evaluation Plan (TEP) This STEP encompasses all testing activities required to demonstrate compliance to the project design criteria as it relates to the modifications of the AN-A valve pit. The Project Design Specifications (PDS) identify the specific testing activities required for the Project. Testing includes Validations and Verifications (e.g., Commercial Grade Item Dedication activities), Factory Acceptance Tests (FATs), installation tests and inspections, Construction Acceptance Tests (CATs), Acceptance Test Procedures (ATPs), Pre-Operational Test Procedures (POTPs), and Operational Test Procedures (OTPs). It should be noted that POTPs are not required for testing of the modifications to the 241-AN-A Valve Pit. The STEP will be utilized in conjunction with the TEP for verification and validation.

  14. Sex-specific and race-specific hip fracture rates.

    PubMed Central

    Kellie, S E; Brody, J A

    1990-01-01

    Sex-, race- and age-specific hip fracture rates were determined using Health Care Financing Administration data for Medicare-reimbursed hip fracture hospitalizations from 1980 to 1982. Rates were highest in White women, lowest in Black men, and intermediate in White men and Black women. Proportions of hip fracture patients dying during hospitalization and those discharged to nursing homes, respectively, were: White men (10.5%; 49%); Black men (9.3%; 32%); White women (5.0%; 54%); and Black women (8.2%; 30%). PMID:2305917

  15. How specific is specific phobia? Different neural response patterns in two subtypes of specific phobia.

    PubMed

    Lueken, Ulrike; Kruschwitz, Johann Daniel; Muehlhan, Markus; Siegert, Jens; Hoyer, Jürgen; Wittchen, Hans-Ulrich

    2011-05-01

    Specific phobia of the animal subtype has been employed as a model disorder exploring the neurocircuitry of anxiety disorders, but evidence is lacking whether the detected neural response pattern accounts for all animal subtypes, nor across other phobia subtypes. The present study aimed at directly comparing two subtypes of specific phobia: snake phobia (SP) representing the animal, and dental phobia (DP) representing the blood-injection-injury subtype. Using functional magnetic resonance imaging (fMRI), brain activation and skin conductance was measured during phobogenic video stimulation in 12 DP, 12 SP, and 17 healthy controls. For SP, the previously described activation of fear circuitry structures encompassing the insula, anterior cingulate cortex and thalamus could be replicated and was furthermore associated with autonomic arousal. In contrast, DP showed circumscribed activation of the prefrontal and orbitofrontal cortex (PFC/OFC) when directly compared to SP, being dissociated from autonomic arousal. Results provide preliminary evidence for the idea that snake and dental phobia are characterized by distinct underlying neural systems during sustained emotional processing with evaluation processes in DP being controlled by orbitofrontal areas, whereas phobogenic reactions in SP are primarily guided by limbic and paralimbic structures. Findings support the current diagnostic classification conventions, separating distinct subtypes in DSM-IV-TR. They highlight that caution might be warranted though for generalizing findings derived from animal phobia to other phobic and anxiety disorders. If replicated, results could contribute to a better understanding of underlying neurobiological mechanisms of specific phobia and their respective classification.

  16. Project X functional requirements specification

    SciTech Connect

    Holmes, S.D.; Henderson, S.D.; Kephart, R.; Kerby, J.; Kourbanis, I.; Lebedev, V.; Mishra, S.; Nagaitsev, S.; Solyak, N.; Tschirhart, R.; /Fermilab

    2012-05-01

    Project X is a multi-megawatt proton facility being developed to support a world-leading program in Intensity Frontier physics at Fermilab. The facility is designed to support programs in elementary particle and nuclear physics, with possible applications to nuclear energy research. A Functional Requirements Specification has been developed in order to establish performance criteria for the Project X complex in support of these multiple missions, and to assure that the facility is designed with sufficient upgrade capability to provide U.S. leadership for many decades to come. This paper will briefly review the previously described Functional Requirements, and then discuss their recent evolution.

  17. Restoring HIV-specific immunity.

    PubMed

    James, J S

    1999-02-12

    When HIV is controlled with antiretrovirals, immunity to other infections often returns. Sometimes patients can stop prophylactic treatment, and sometimes opportunistic infections can clear up without treatment. However, immunity to HIV itself does not return, or returns very slowly, even when HIV has been suppressed for years with drug therapy. Researchers do not know why HIV immunity reacts differently, but several possible approaches to restoring HIV-specific immunity are being researched. One approach involves a therapeutic vaccination while the virus is well suppressed with antiretrovirals. The other approach is beginning HIV treatment very early, before the virus begins destroying the cells that recognize it. Several studies are discussed.

  18. Functional specificity of PMCA isoforms?

    PubMed

    Domi, Teuta; Di Leva, Francesca; Fedrizzi, Laura; Rimessi, Alessandro; Brini, Marisa

    2007-03-01

    In mammals, four different genes encode four PMCA isoforms. PMCA1 and PMCA4 are expressed ubiquitously. PMCA2 and PMCA3 are expressed prevalently in the central nervous systems. More than 30 variants are generated by mechanisms of alternative splicing. The physiological meaning of the existence of such elevated number of isoforms is not clear, but it would be plausible to relate it to the cell-specific demands of Ca2+ homeostasis. To characterize functional specificity of PMCA variants we have investigated two aspects: the effects of the overexpression of the different PMCA variants on cellular Ca2+ handling and the existence of possible isoform-specific interactions with partner proteins using a yeast two-hybrid technique. The four basic PMCA isoforms were coexpressed in CHO cells together with the Ca2+-sensitive recombinant photoprotein aequorin. The effects of their overexpression on Ca2+ homeostasis were monitored in the living cells. They had revealed that the ubiquitous isoforms 1 and 4 are less effective in reducing the Ca2+ peaks generated by cell stimulation as compared to the neuron-specific isoforms 2 and 3. To establish whether these differences were related to different and new physiological regulators of the pump, the 90 N-terminal residues of PMCA2 and PMCA4 have been used as baits for the search of molecular partners. Screening of a human brain cDNA library with the PMCA4 bait specified the epsilon-isoform of protein 14-3-3, whereas no 14-3-3 epsilon clone was obtained with the PMCA2 bait. Overexpression of PMCA4/14-3-3 epsilon (but not of PMCA2/14-3-3 epsilon) in HeLa cells together with targeted aequorins showed that the ability of the cells to export Ca2+ was impaired. Thus, the interaction with 14-3-3 epsilon inhibited PMCA4 but not PMCA2. The role of PMCA2 has been further characterized by Ca2+ measurements in cells overexpressing different splicing variants. The results indicated that the combination of alternative splicing at two different

  19. Central Solenoid Insert Technical Specification

    SciTech Connect

    Martovetsky, Nicolai N; Smirnov, Alexandre

    2011-09-01

    The US ITER Project Office (USIPO) is responsible for the ITER central solenoid (CS) contribution to the ITER project. The Central Solenoid Insert (CSI) project will allow ITER validation the appropriate lengths of the conductors to be used in the full-scale CS coils under relevant conditions. The ITER Program plans to build and test a CSI to verify the performance of the CS conductor. The CSI is a one-layer solenoid with an inner diameter of 1.48 m and a height of 4.45 m between electric terminal ends. The coil weight with the terminals is approximately 820 kg without insulation. The major goal of the CSI is to measure the temperature margin of the CS under the ITER direct current (DC) operating conditions, including determining sensitivity to load cycles. Performance of the joints, ramp rate sensitivity, and stability against thermal or electromagnetic disturbances, electrical insulation, losses, and instrumentation are addressed separately and therefore are not major goals in this project. However, losses and joint performance will be tested during the CSI testing campaign. The USIPO will build the CSI that will be tested at the Central Solenoid Model Coil (CSMC) Test Facility at the Japan Atomic Energy Agency (JAEA), Naka, Japan. The industrial vendors (the Suppliers) will report to the USIPO (the Company). All approvals to proceed will be issued by the Company, which in some cases, as specified in this document, will also require the approval of the ITER Organization. Responsibilities and obligations will be covered by respective contracts between the USIPO, called Company interchangeably, and the industrial Prime Contractors, called Suppliers. Different stages of work may be performed by more than one Prime Contractor, as described in this specification. Technical requirements of the contract between the Company and the Prime Contractor will be covered by the Fabrication Specifications developed by the Prime Contractor based on this document and approved by

  20. Logic programming and metadata specifications

    NASA Technical Reports Server (NTRS)

    Lopez, Antonio M., Jr.; Saacks, Marguerite E.

    1992-01-01

    Artificial intelligence (AI) ideas and techniques are critical to the development of intelligent information systems that will be used to collect, manipulate, and retrieve the vast amounts of space data produced by 'Missions to Planet Earth.' Natural language processing, inference, and expert systems are at the core of this space application of AI. This paper presents logic programming as an AI tool that can support inference (the ability to draw conclusions from a set of complicated and interrelated facts). It reports on the use of logic programming in the study of metadata specifications for a small problem domain of airborne sensors, and the dataset characteristics and pointers that are needed for data access.

  1. IntelliCable Interface Specification

    DTIC Science & Technology

    2016-07-14

    Specification Page 9 Layer 1 – Physical Each IntelliCable shall identify its capabilities and needed output using a 1- Wire storage and signaling...device. Some informative sites are listed below:  Dallas Semi / Maxim – http://www.maxim-ic.com/products/1- wire /  1- Wire industry standards – http...www.1wire.org A typical IntelliCable will use a simple memory device, such as a DS2431. Other cables may use 1- Wire devices with built-in sense

  2. Substrate Specificity of Prostate-Specific Membrane Antigen

    PubMed Central

    Anderson, Marc O.; Wu, Lisa Y.; Santiago, Nicholas M.; Moser, Jamie M.; Rowley, Jennifer A.; Bolstad, Erin S. D.; Berkman, Clifford E.

    2007-01-01

    A series of putative dipeptide substrates of prostate specific membrane antigen (PSMA) was prepared that explored α- and β/γ-linked acidic residues at the P1 position and various chromophores at the P2 position, while keeping the P1’ residue constant as L-Glu. Four chromophores were examined, including 4-phenylazobenzoyl, 1-pyrenebutyrl, 9-anthracenylcarboxyl-γ-aminobutyrl, and 4-nitrophenylbutyryl. When evaluating these chromophores, it was found that a substrate containing 4-phenylazobenzoyl at the P2 position was consumed most efficiently. Substitution at the P1 position with acidic residues showed that only γ-linked L-Glu and D-Glu were recognized by the enzyme, with the former being more readily proteolyzed. Lastly, binding modes of endogenous substrates and our best synthetic substrate (4-phenylazobenzoyl-Glu-γ-Glu) were proposed by computational docking studies into an X-ray crystal structure of the PSMA extracellular domain. PMID:17764959

  3. Inhibitors of specific ceramide synthases.

    PubMed

    Schiffmann, Susanne; Hartmann, Daniela; Fuchs, Sina; Birod, Kerstin; Ferreiròs, Nerea; Schreiber, Yannick; Zivkovic, Aleksandra; Geisslinger, Gerd; Grösch, Sabine; Stark, Holger

    2012-02-01

    Ceramide synthases (CerSs) are key enzymes in the biosynthesis of ceramides and display a group of at least six different isoenzymes (CerS1-6). Ceramides itself are bioactive molecules. Ceramides with different N-acyl side chains (C(14:0)-Cer - C(26:0)-Cer) possess distinct roles in cell signaling. Therefore, the selective inhibition of specific CerSs which are responsible for the formation of a specific ceramide holds promise for a number of new clinical treatment strategies, e.g., cancer. Here, we identified four of hitherto unknown functional inhibitors of CerSs derived from the FTY720 (Fingolimod) lead structure and showed their inhibitory effectiveness by two in vitro CerS activity assays. Additionally, we tested the substances in two cell lines (HCT-116 and HeLa) with different ceramide patterns. In summary, the in vitro activity assays revealed out that ST1058 and ST1074 preferentially inhibit CerS2 and CerS4, while ST1072 inhibits most potently CerS4 and CerS6. Importantly, ST1060 inhibits predominately CerS2. First structure-activity relationships and the potential biological impact of these compounds are discussed.

  4. Flight Guidance System Requirements Specification

    NASA Technical Reports Server (NTRS)

    Miller, Steven P.; Tribble, Alan C.; Carlson, Timothy M.; Danielson, Eric J.

    2003-01-01

    This report describes a requirements specification written in the RSML-e language for the mode logic of a Flight Guidance System of a typical regional jet aircraft. This model was created as one of the first steps in a five-year project sponsored by the NASA Langley Research Center, Rockwell Collins Inc., and the Critical Systems Research Group of the University of Minnesota to develop new methods and tools to improve the safety of avionics designs. This model will be used to demonstrate the application of a variety of methods and techniques, including safety analysis of system and subsystem requirements, verification of key properties using theorem provers and model checkers, identification of potential sources mode confusion in system designs, partitioning of applications based on the criticality of system hazards, and autogeneration of avionics quality code. While this model is representative of the mode logic of a typical regional jet aircraft, it does not describe an actual or planned product. Several aspects of a full Flight Guidance System, such as recovery from failed sensors, have been omitted, and no claims are made regarding the accuracy or completeness of this specification.

  5. Arithmetic Memory Is Modality Specific

    PubMed Central

    Myers, Timothy; Szücs, Dénes

    2015-01-01

    In regards to numerical cognition and working memory, it is an open question as to whether numbers are stored into and retrieved from a central abstract representation or from separate notation-specific representations. This study seeks to help answer this by utilizing the numeral modality effect (NME) in three experiments to explore how numbers are processed by the human brain. The participants were presented with numbers (1–9) as either Arabic digits or written number words (Arabic digits and dot matrices in Experiment 2) at the first (S1) and second (S2) stimuli. The participant’s task was to add the first two stimuli together and verify whether the answer (S3), presented simultaneously with S2, was correct. We hypothesized that if reaction time (RT) at S2/S3 depends on the modality of S1 then numbers are retrieved from modality specific memory stores. Indeed, RT depended on the modality of S1 whenever S2 was an Arabic digit which argues against the concept of numbers being stored and retrieved from a central, abstract representation. PMID:26716692

  6. Molecular-specific urokinase antibodies

    NASA Technical Reports Server (NTRS)

    Atassi, M. Zouhair (Inventor); Morrison, Dennis R. (Inventor)

    2009-01-01

    Antibodies have been developed against the different molecular forms of urokinase using synthetic peptides as immunogens. The peptides were synthesized specifically to represent those regions of the urokinase molecules which are exposed in the three-dimensional configuration of the molecule and are uniquely homologous to urokinase. Antibodies are directed against the lysine 158-isoleucine 159 peptide bond which is cleaved during activation from the single-chain (ScuPA) form to the bioactive double chain (54 KDa and 33 KDa) forms of urokinase and against the lysine 135 lysine 136 bond that is cleaved in the process of removing the alpha-chain from the 54 KDa form to produce the 33 KDa form of urokinase. These antibodies enable the direct measurement of the different molecular forms of urokinase from small samples of conditioned medium harvested from cell cultures.

  7. Genetic specificity of face recognition.

    PubMed

    Shakeshaft, Nicholas G; Plomin, Robert

    2015-10-13

    Specific cognitive abilities in diverse domains are typically found to be highly heritable and substantially correlated with general cognitive ability (g), both phenotypically and genetically. Recent twin studies have found the ability to memorize and recognize faces to be an exception, being similarly heritable but phenotypically substantially uncorrelated both with g and with general object recognition. However, the genetic relationships between face recognition and other abilities (the extent to which they share a common genetic etiology) cannot be determined from phenotypic associations. In this, to our knowledge, first study of the genetic associations between face recognition and other domains, 2,000 18- and 19-year-old United Kingdom twins completed tests assessing their face recognition, object recognition, and general cognitive abilities. Results confirmed the substantial heritability of face recognition (61%), and multivariate genetic analyses found that most of this genetic influence is unique and not shared with other cognitive abilities.

  8. MATISSE: specifications and expected performances

    NASA Astrophysics Data System (ADS)

    Matter, A.; Lagarde, S.; Petrov, R. G.; Berio, P.; Robbe-Dubois, S.; Lopez, B.; Antonelli, P.; Allouche, F.; Cruzalebes, P.; Millour, F.; Bazin, G.; Bourgès, L.

    2016-08-01

    MATISSE (Multi AperTure mid-Infrared SpectroScopic Experiment) is the next generation spectro-interferometer at the European Southern Observatory VLTI operating in the spectral bands L, M and N, and combining four beams from the unit and auxiliary telescopes. MATISSE is now fully integrated at the Observatoire de la Côte d'Azur in Nice (France), and has entered very recently its testing phase in laboratory. This paper summarizes the equations describing the MATISSE signal and the associated sources of noise. The specifications and the expected performances of the instrument are then evaluated taking into account the current characteristics of the instrument and the VLTI infrastructure, including transmission and contrast degradation budgets. In addition, we present the different MATISSE simulation tools that will be made available to the future users.

  9. Specific Language Impairment Across Languages.

    PubMed

    Leonard, Laurence B

    2014-03-01

    Children with specific language impairment (SLI) have a significant and longstanding deficit in spoken language ability that adversely affects their social and academic well-being. Studies of children with SLI in a wide variety of languages reveal diverse symptoms, most of which seem to reflect weaknesses in grammatical computation and phonological short-term memory. The symptoms of the disorder are sensitive to the type of language being acquired, with extraordinary weaknesses seen in those areas of language that are relatively challenging for younger typically developing children. Although these children's deficits warrant clinical and educational attention, their weaknesses might reflect the extreme end of a language aptitude continuum rather than a distinct, separable condition.

  10. LAS bioconcentration is isomer specific

    SciTech Connect

    Tolls, J.; Haller, M.; Graaf, I. de; Thijssen, M.H.C.; Sijm, D.T.H.M.

    1995-12-31

    The authors measured parent compound specific bioconcentration data for linear alkylbenzene sulfonates in Pimephales promelas. They did so by using cold, custom synthesized sulfophenyl alkanes. They observed that, within homologous series of isomers, the uptake rate constants (k{sub 1}) and the bioconcentration factor (BCF) increase with increasing number of carbon atoms in the alkyl chain (n{sub C-atoms}). In contrast, the elimination rate constant k{sub 2} appears to be independent of the alkyl chain length. Regressions of log BCF vs n{sub C-atoms} yielded different slopes for the homologous groups of the 5- and the 2-sulfophenyl alkane isomers. Regression of all log BCF-data vs log 1/CMC yielded a good description of the data. However, when regressing the data for both homologous series separately again very different slopes are obtained. The results therefore indicate that hydrophobicity-bioconcentration relationships may be different for different homologous groups of sulfophenyl alkanes.

  11. Specific test and evaluation plan

    SciTech Connect

    Hays, W.H.

    1998-03-20

    The purpose of this Specific Test and Evaluation Plan (STEP) is to provide a detailed written plan for the systematic testing of modifications made to the 241-AX-B Valve Pit by the W-314 Project. The STEP develops the outline for test procedures that verify the system`s performance to the established Project design criteria. The STEP is a lower tier document based on the W-314 Test and Evaluation Plan (TEP). Testing includes Validations and Verifications (e.g., Commercial Grade Item Dedication activities), Factory Acceptance Tests (FATs), installation tests and inspections, Construction Acceptance Tests (CATs), Acceptance Test Procedures (ATPs), Pre-Operational Test Procedures (POTPs), and Operational Test Procedures (OTPs). It should be noted that POTPs are not required for testing of the transfer line addition. The STEP will be utilized in conjunction with the TEP for verification and validation.

  12. Formal specification of human-computer interfaces

    NASA Technical Reports Server (NTRS)

    Auernheimer, Brent

    1990-01-01

    A high-level formal specification of a human computer interface is described. Previous work is reviewed and the ASLAN specification language is described. Top-level specifications written in ASLAN for a library and a multiwindow interface are discussed.

  13. Specific Carbohydrate Diet: Does It Work?

    MedlinePlus

    ... Specific Carbohydrate Diet (SCD) Go Back The Specific Carbohydrate Diet (SCD) Email Print + Share There is no ... diet that has received attention is the Specific Carbohydrate Diet. This diet limits poorly digestible carbohydrates to ...

  14. Application-Specific Super Computer

    NASA Astrophysics Data System (ADS)

    Lackey, Raymond J.; Baurle, Herbert F.; Barile, John

    1989-12-01

    Super Computer processing levels will be necessary to implement real time functions in radar and communication systems. Design and fabrication of such systems require innovative approaches in addressing the problem rather than the normal methods of solution. The mathematical solution to multiple simultaneous equations is the optimum solution in many signal processing problems in radar and communications. Historically this optimum solution was not directly possible, so approximations were derived through various signal processing techniques. The advent of high-speed digital processing devices in concurrent processing architectures has raised the possibility of achieving the optimum solution. This mathematical solution is applicable to many adaptive signal processing problems including spatial, spectral, temporal, and moving target indication filtering. Hazeltine, under contract with RADC on the Systolic Array Processor Brassboard program, has built a processor solving this class of problems in a highly concurrent systolic processing architecture. The application-specific processor built on this program performs over 1.25 billion floating point operations per second (BFLOPS), solving equations with up to twelve complex variables.

  15. Are specific emotions narrated differently?

    PubMed

    Habermas, Tilmann; Meier, Michaela; Mukhtar, Barbara

    2009-12-01

    Two studies test the assertion that anger, sadness, fear, pride, and happiness are typically narrated in different ways. Everyday events eliciting these 5 emotions were narrated by young women (Study 1) and 5- and 8-year-old girls (Study 2). Negative narratives were expected to engender more effort to process the event, be longer, more grammatically complex, more often have a complication section, and use more specific emotion labels than global evaluations. Narratives of Hogan's (2003) juncture emotions anger and fear were expected to focus more on action and to contain more core narrative sections of orientation, complication, and resolution than narratives of the outcome emotions sadness and happiness. Hypotheses were confirmed for adults except for syntactic complexity, whereas children showed only some of these differences. Hogan's theory that juncture emotions are restricted to the complication section was not confirmed. Finally, in adults, indirect speech was more frequent in anger narratives and internal monologue in fear narratives. It is concluded that different emotions should be studied in how they are narrated, and that narratives should be analyzed according to qualitatively different emotions.

  16. High specific activity silicon-32

    DOEpatents

    Phillips, Dennis R.; Brzezinski, Mark A.

    1996-01-01

    A process for preparation of silicon-32 is provided and includes contacting an irradiated potassium chloride target, including spallation products from a prior irradiation, with sufficient water, hydrochloric acid or potassium hydroxide to form a solution, filtering the solution, adjusting pH of the solution to from about 5.5 to about 7.5, admixing sufficient molybdate-reagent to the solution to adjust the pH of the solution to about 1.5 and to form a silicon-molybdate complex, contacting the solution including the silicon-molybdate complex with a dextran-based material, washing the dextran-based material to remove residual contaminants such as sodium-22, separating the silicon-molybdate complex from the dextran-based material as another solution, adding sufficient hydrochloric acid and hydrogen peroxide to the solution to prevent reformation of the silicon-molybdate complex and to yield an oxidization state of the molybdate adapted for subsequent separation by an anion exchange material, contacting the solution with an anion exchange material whereby the molybdate is retained by the anion exchange material and the silicon remains in solution, and optionally adding sufficient alkali metal hydroxide to adjust the pH of the solution to about 12 to 13. Additionally, a high specific activity silicon-32 product having a high purity is provided.

  17. High specific activity silicon-32

    DOEpatents

    Phillips, D.R.; Brzezinski, M.A.

    1996-06-11

    A process for preparation of silicon-32 is provided and includes contacting an irradiated potassium chloride target, including spallation products from a prior irradiation, with sufficient water, hydrochloric acid or potassium hydroxide to form a solution, filtering the solution, adjusting pH of the solution from about 5.5 to about 7.5, admixing sufficient molybdate-reagent to the solution to adjust the pH of the solution to about 1.5 and to form a silicon-molybdate complex, contacting the solution including the silicon-molybdate complex with a dextran-based material, washing the dextran-based material to remove residual contaminants such as sodium-22, separating the silicon-molybdate complex from the dextran-based material as another solution, adding sufficient hydrochloric acid and hydrogen peroxide to the solution to prevent reformation of the silicon-molybdate complex and to yield an oxidation state of the molybdate adapted for subsequent separation by an anion exchange material, contacting the solution with an anion exchange material whereby the molybdate is retained by the anion exchange material and the silicon remains in solution, and optionally adding sufficient alkali metal hydroxide to adjust the pH of the solution to about 12 to 13. Additionally, a high specific activity silicon-32 product having a high purity is provided.

  18. 77 FR 27814 - Model Safety Evaluation for Plant-Specific Adoption of Technical Specifications Task Force...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-11

    ... COMMISSION Model Safety Evaluation for Plant-Specific Adoption of Technical Specifications Task Force... Consolidated Line Item Improvement Process AGENCY: Nuclear Regulatory Commission. ACTION: Notice of... safety evaluation (SE) for plant-specific adoption of Technical Specifications (TSs) Task Force...

  19. 46 CFR 174.010 - Specific applicability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PERTAINING TO SPECIFIC VESSEL TYPES Special Rules Pertaining to Deck Cargo Barges § 174.010 Specific applicability. Each barge that carries cargo above the weather deck must comply with this subpart....

  20. Non-Specific Immunotherapies and Adjuvants

    MedlinePlus

    ... and Side Effects Treatment Types Immunotherapy Non-specific cancer immunotherapies and adjuvants Non-specific immunotherapies don’t target ... This makes BCG useful as a form of cancer immunotherapy. BCG was one of the earliest immunotherapies used ...

  1. 21 CFR 660.44 - Specificity.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Hepatitis B Surface Antigen § 660.44 Specificity. Each filling of the product shall be specific for Hepatitis B Surface Antigen as determined...

  2. 21 CFR 660.44 - Specificity.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Hepatitis B Surface Antigen § 660.44 Specificity. Each filling of the product shall be specific for Hepatitis B Surface Antigen as determined...

  3. 21 CFR 660.44 - Specificity.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Hepatitis B Surface Antigen § 660.44 Specificity. Each filling of the product shall be specific for Hepatitis B Surface Antigen as determined...

  4. 21 CFR 660.44 - Specificity.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Hepatitis B Surface Antigen § 660.44 Specificity. Each filling of the product shall be specific for Hepatitis B Surface Antigen as determined...

  5. 21 CFR 660.5 - Specificity.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Antibody to Hepatitis B Surface Antigen § 660.5 Specificity. Each filling of the product shall be specific for antibody to hepatitis B surface antigen,...

  6. 21 CFR 660.5 - Specificity.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Antibody to Hepatitis B Surface Antigen § 660.5 Specificity. Each filling of the product shall be specific for antibody to hepatitis B surface antigen,...

  7. 21 CFR 660.5 - Specificity.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Antibody to Hepatitis B Surface Antigen § 660.5 Specificity. Each filling of the product shall be specific for antibody to hepatitis B surface antigen,...

  8. 21 CFR 660.5 - Specificity.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Antibody to Hepatitis B Surface Antigen § 660.5 Specificity. Each filling of the product shall be specific for antibody to hepatitis B surface antigen,...

  9. 21 CFR 660.5 - Specificity.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Antibody to Hepatitis B Surface Antigen § 660.5 Specificity. Each filling of the product shall be specific for antibody to hepatitis B surface antigen,...

  10. 21 CFR 660.44 - Specificity.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Hepatitis B Surface Antigen § 660.44 Specificity. Each filling of the product shall be specific for Hepatitis B Surface Antigen as determined...

  11. Goddard trajectory determination subsystem: Mathematical specifications

    NASA Technical Reports Server (NTRS)

    Wagner, W. E. (Editor); Velez, C. E. (Editor)

    1972-01-01

    The mathematical specifications of the Goddard trajectory determination subsystem of the flight dynamics system are presented. These specifications include the mathematical description of the coordinate systems, dynamic and measurement model, numerical integration techniques, and statistical estimation concepts.

  12. Model Commissioning Plan and Guide Specifications

    SciTech Connect

    1997-03-01

    The objectives of Model Commissioning Plan and Guide Specifications are to ensure that the design team applies commissioning concepts to the design and prepares commissioning specifications and a commission plan for inclusion in the bid construction documents.

  13. 46 CFR 174.030 - Specific applicability.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... PERTAINING TO SPECIFIC VESSEL TYPES Special Rules Pertaining to Mobile Offshore Drilling Units § 174.030 Specific applicability. Each mobile offshore drilling unit (MODU) inspected under Subchapter IA of...

  14. 46 CFR 174.030 - Specific applicability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PERTAINING TO SPECIFIC VESSEL TYPES Special Rules Pertaining to Mobile Offshore Drilling Units § 174.030 Specific applicability. Each mobile offshore drilling unit (MODU) inspected under Subchapter IA of...

  15. Low temperature specific heat of propylene glycol

    SciTech Connect

    Zhu, Da-Ming; Chen, Huiwei

    1997-01-01

    The specific heat of propylene glycol has been measured at temperatures from 0.1 K to 6 K. The magnitude and the temperature dependence of the specific heat are similar to that found in other fragile glasses.

  16. Domain and Specification Models for Software Engineering

    NASA Technical Reports Server (NTRS)

    Iscoe, Neil; Liu, Zheng-Yang; Feng, Guohui

    1992-01-01

    This paper discusses our approach to representing application domain knowledge for specific software engineering tasks. Application domain knowledge is embodied in a domain model. Domain models are used to assist in the creation of specification models. Although many different specification models can be created from any particular domain model, each specification model is consistent and correct with respect to the domain model. One aspect of the system-hierarchical organization is described in detail.

  17. Methods for chromosome-specific staining

    DOEpatents

    Gray, Joe W.; Pinkel, Daniel

    1995-01-01

    Methods and compositions for chromosome-specific staining are provided. Compositions comprise heterogenous mixtures of labeled nucleic acid fragments having substantially complementary base sequences to unique sequence regions of the chromosomal DNA for which their associated staining reagent is specific. Methods include methods for making the chromosome-specific staining compositions of the invention, and methods for applying the staining compositions to chromosomes.

  18. Information Concerning Preparation of Specifications for Carpeting.

    ERIC Educational Resources Information Center

    Gilliland, John W.

    This paper argues for detailed, written carpeting specifications to assure that schools obtain quality products at competitive prices. The advantages of and specifications for school carpeting are given. A sample written specification contains items on: scope, general features, materials, acoustic characteristics, identification and acoustic…

  19. 40 CFR 87.81 - Fuel specifications.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 21 2012-07-01 2012-07-01 false Fuel specifications. 87.81 Section 87...) Definitions. Test Procedures for Engine Smoke Emissions (Aircraft Gas Turbine Engines) § 87.81 Fuel specifications. Fuel having specifications as provided in § 87.61 shall be used in smoke emission testing....

  20. 40 CFR 87.81 - Fuel specifications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Fuel specifications. 87.81 Section 87.81 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... (Aircraft Gas Turbine Engines) § 87.81 Fuel specifications. Fuel having specifications as provided in §...

  1. 40 CFR 86.1413 - Fuel specifications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 19 2010-07-01 2010-07-01 false Fuel specifications. 86.1413 Section... Trucks; Certification Short Test Procedures § 86.1413 Fuel specifications. (a) The test fuel to be used... octane specification of the fuels does not apply. For all gasoline-fueled Otto-cycle light-duty...

  2. 40 CFR 86.1413 - Fuel specifications.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 20 2013-07-01 2013-07-01 false Fuel specifications. 86.1413 Section... Trucks; Certification Short Test Procedures § 86.1413 Fuel specifications. (a) The test fuel to be used... octane specification of the fuels does not apply. For all gasoline-fueled Otto-cycle light-duty...

  3. 14 CFR 34.81 - Fuel specifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Fuel specifications. 34.81 Section 34.81 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT FUEL VENTING AND... Emissions (Aircraft Gas Turbine Engines) § 34.81 Fuel specifications. Fuel having specifications as...

  4. 40 CFR 86.1413 - Fuel specifications.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 20 2012-07-01 2012-07-01 false Fuel specifications. 86.1413 Section... Trucks; Certification Short Test Procedures § 86.1413 Fuel specifications. (a) The test fuel to be used... octane specification of the fuels does not apply. For all gasoline-fueled Otto-cycle light-duty...

  5. 14 CFR 34.81 - Fuel specifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Fuel specifications. 34.81 Section 34.81 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT FUEL VENTING AND... Emissions (Aircraft Gas Turbine Engines) § 34.81 Fuel specifications. Fuel having specifications as...

  6. 40 CFR 86.1413 - Fuel specifications.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 19 2011-07-01 2011-07-01 false Fuel specifications. 86.1413 Section... Trucks; Certification Short Test Procedures § 86.1413 Fuel specifications. (a) The test fuel to be used... octane specification of the fuels does not apply. For all gasoline-fueled Otto-cycle light-duty...

  7. 14 CFR 34.81 - Fuel specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Fuel specifications. 34.81 Section 34.81 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT FUEL VENTING AND... Emissions (Aircraft Gas Turbine Engines) § 34.81 Fuel specifications. Fuel having specifications as...

  8. 40 CFR 87.81 - Fuel specifications.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 20 2011-07-01 2011-07-01 false Fuel specifications. 87.81 Section 87.81 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... (Aircraft Gas Turbine Engines) § 87.81 Fuel specifications. Fuel having specifications as provided in §...

  9. 40 CFR 247.5 - Specifications.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Specifications. 247.5 Section 247.5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES COMPREHENSIVE PROCUREMENT... specifications for procurement items procured by Federal agencies to revise their specifications by May 8,...

  10. 77 FR 15399 - Model Safety Evaluation for Plant-Specific Adoption of Technical Specifications Task Force...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-15

    ... COMMISSION Model Safety Evaluation for Plant-Specific Adoption of Technical Specifications Task Force...-specific adoption of Technical Specifications (TS) Task Force (TSTF) Traveler TSTF-505, Revision 1... ADAMS under Accession No. ML12032A065. The model SE for plant-specific adoption of TSTF-505, Revision...

  11. Requirements Specification Language (RSL) and supporting tools

    NASA Technical Reports Server (NTRS)

    Frincke, Deborah; Wolber, Dave; Fisher, Gene; Cohen, Gerald C.

    1992-01-01

    This document describes a general purpose Requirement Specification Language (RSL). RSL is a hybrid of features found in several popular requirement specification languages. The purpose of RSL is to describe precisely the external structure of a system comprised of hardware, software, and human processing elements. To overcome the deficiencies of informal specification languages, RSL includes facilities for mathematical specification. Two RSL interface tools are described. The Browser view contains a complete document with all details of the objects and operations. The Dataflow view is a specialized, operation-centered depiction of a specification that shows how specified operations relate in terms of inputs and outputs.

  12. A Computational Model of Semantic Memory Impairment: Modality- Specificity and Emergent Category-Specificity

    DTIC Science & Technology

    1991-09-01

    article we demonstrate how a modality-specific semantic memory system can account for category- specific impairments after brain damage. Specifically...different sensorimotor channels. In this article we demonstrate how a modality-specific semantic memory system can account for category-specific...just one modality (e.g. visual or auditory agnosia ) or impaired manipulation of objects with specific uses, despite intact recognition of them (apraxia

  13. Identification of tissue-specific targeting peptide

    NASA Astrophysics Data System (ADS)

    Jung, Eunkyoung; Lee, Nam Kyung; Kang, Sang-Kee; Choi, Seung-Hoon; Kim, Daejin; Park, Kisoo; Choi, Kihang; Choi, Yun-Jaie; Jung, Dong Hyun

    2012-11-01

    Using phage display technique, we identified tissue-targeting peptide sets that recognize specific tissues (bone-marrow dendritic cell, kidney, liver, lung, spleen and visceral adipose tissue). In order to rapidly evaluate tissue-specific targeting peptides, we performed machine learning studies for predicting the tissue-specific targeting activity of peptides on the basis of peptide sequence information using four machine learning models and isolated the groups of peptides capable of mediating selective targeting to specific tissues. As a representative liver-specific targeting sequence, the peptide "DKNLQLH" was selected by the sequence similarity analysis. This peptide has a high degree of homology with protein ligands which can interact with corresponding membrane counterparts. We anticipate that our models will be applicable to the prediction of tissue-specific targeting peptides which can recognize the endothelial markers of target tissues.

  14. Methods for chromosome-specific staining

    DOEpatents

    Gray, J.W.; Pinkel, D.

    1995-09-05

    Methods and compositions for chromosome-specific staining are provided. Compositions comprise heterogeneous mixtures of labeled nucleic acid fragments having substantially complementary base sequences to unique sequence regions of the chromosomal DNA for which their associated staining reagent is specific. Methods include ways for making the chromosome-specific staining compositions of the invention, and methods for applying the staining compositions to chromosomes. 3 figs.

  15. High flux isotope reactor technical specifications

    SciTech Connect

    Not Available

    1982-04-01

    Technical specifications are presented concerning safety limits and limiting safety system settings; limiting conditions for operation; surveillance requirements; design features; administrative controls; and accidents and anticipated transients.

  16. Formal specification and verification of Ada software

    NASA Technical Reports Server (NTRS)

    Hird, Geoffrey R.

    1991-01-01

    The use of formal methods in software development achieves levels of quality assurance unobtainable by other means. The Larch approach to specification is described, and the specification of avionics software designed to implement the logic of a flight control system is given as an example. Penelope is described which is an Ada-verification environment. The Penelope user inputs mathematical definitions, Larch-style specifications and Ada code and performs machine-assisted proofs that the code obeys its specifications. As an example, the verification of a binary search function is considered. Emphasis is given to techniques assisting the reuse of a verification effort on modified code.

  17. 77 FR 69507 - Proposed Model Safety Evaluation for Plant-Specific Adoption of Technical Specifications Task...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-19

    ... COMMISSION Proposed Model Safety Evaluation for Plant-Specific Adoption of Technical Specifications Task... Designs'' AGENCY: Nuclear Regulatory Commission. ACTION: Notice of opportunity for public comment. SUMMARY... evaluation (SE) for plant- specific adoption of Technical Specifications (TS) Task Force (TSTF) Traveler...

  18. User Interface Technology for Formal Specification Development

    NASA Technical Reports Server (NTRS)

    Lowry, Michael; Philpot, Andrew; Pressburger, Thomas; Underwood, Ian; Lum, Henry, Jr. (Technical Monitor)

    1994-01-01

    Formal specification development and modification are an essential component of the knowledge-based software life cycle. User interface technology is needed to empower end-users to create their own formal specifications. This paper describes the advanced user interface for AMPHION1 a knowledge-based software engineering system that targets scientific subroutine libraries. AMPHION is a generic, domain-independent architecture that is specialized to an application domain through a declarative domain theory. Formal specification development and reuse is made accessible to end-users through an intuitive graphical interface that provides semantic guidance in creating diagrams denoting formal specifications in an application domain. The diagrams also serve to document the specifications. Automatic deductive program synthesis ensures that end-user specifications are correctly implemented. The tables that drive AMPHION's user interface are automatically compiled from a domain theory; portions of the interface can be customized by the end-user. The user interface facilitates formal specification development by hiding syntactic details, such as logical notation. It also turns some of the barriers for end-user specification development associated with strongly typed formal languages into active sources of guidance, without restricting advanced users. The interface is especially suited for specification modification. AMPHION has been applied to the domain of solar system kinematics through the development of a declarative domain theory. Testing over six months with planetary scientists indicates that AMPHION's interactive specification acquisition paradigm enables users to develop, modify, and reuse specifications at least an order of magnitude more rapidly than manual program development.

  19. Site-specific non-LTR retrotransposons.

    PubMed

    Fujiwara, Haruhiko

    2015-04-01

    Although most of non-long terminal repeat (non-LTR) retrotransposons are incorporated in the host genome almost randomly, some non-LTR retrotransposons are incorporated into specific sequences within a target site. On the basis of structural and phylogenetic features, non-LTR retrotransposons are classified into two large groups, restriction enzyme-like endonuclease (RLE)-encoding elements and apurinic/apyrimidinic endonuclease (APE)-encoding elements. All clades of RLE-encoding non-LTR retrotransposons include site-specific elements. However, only two of more than 20 APE-encoding clades, Tx1 and R1, contain site-specific non-LTR elements. Site-specific non-LTR retrotransposons usually target within multi-copy RNA genes, such as rRNA gene (rDNA) clusters, or repetitive genomic sequences, such as telomeric repeats; this behavior may be a symbiotic strategy to reduce the damage to the host genome. Site- and sequence-specificity are variable even among closely related non-LTR elements and appeared to have changed during evolution. In the APE-encoding elements, the primary determinant of the sequence- specific integration is APE itself, which nicks one strand of the target DNA during the initiation of target primed reverse transcription (TPRT). However, other factors, such as interaction between mRNA and the target DNA, and access to the target region in the nuclei also affect the sequence-specificity. In contrast, in the RLE-encoding elements, DNA-binding motifs appear to affect their sequence-specificity, rather than the RLE domain itself. Highly specific integration properties of these site-specific non-LTR elements make them ideal alternative tools for sequence-specific gene delivery, particularly for therapeutic purposes in human diseases.

  20. 46 CFR 174.300 - Specific applicability.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Specific applicability. 174.300 Section 174.300 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO SPECIFIC VESSEL TYPES Hopper Dredges With Working Freeboard Assignments § 174.300...

  1. 10 CFR 52.7 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Specific exemptions. 52.7 Section 52.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General Provisions § 52.7 Specific exemptions. The Commission may, upon application by any interested person or...

  2. 10 CFR 52.7 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Specific exemptions. 52.7 Section 52.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General Provisions § 52.7 Specific exemptions. The Commission may, upon application by any interested person or...

  3. 10 CFR 52.7 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Specific exemptions. 52.7 Section 52.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General Provisions § 52.7 Specific exemptions. The Commission may, upon application by any interested person or...

  4. 10 CFR 52.7 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Specific exemptions. 52.7 Section 52.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General Provisions § 52.7 Specific exemptions. The Commission may, upon application by any interested person or...

  5. 10 CFR 52.7 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Specific exemptions. 52.7 Section 52.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General Provisions § 52.7 Specific exemptions. The Commission may, upon application by any interested person or...

  6. 14 CFR 25.1397 - Color specifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Color specifications. 25.1397 Section 25... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Equipment Lights § 25.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  7. 14 CFR 27.1397 - Color specifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Color specifications. 27.1397 Section 27... AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Equipment Lights § 27.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  8. 14 CFR 25.1397 - Color specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Color specifications. 25.1397 Section 25... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Equipment Lights § 25.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  9. 14 CFR 23.1397 - Color specifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Color specifications. 23.1397 Section 23.1397 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... Color specifications. Each position light color must have the applicable International Commission...

  10. 14 CFR 29.1397 - Color specifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Color specifications. 29.1397 Section 29... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Lights § 29.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  11. 14 CFR 29.1397 - Color specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Color specifications. 29.1397 Section 29... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Lights § 29.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  12. 14 CFR 25.1397 - Color specifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Color specifications. 25.1397 Section 25... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Equipment Lights § 25.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  13. 14 CFR 29.1397 - Color specifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Color specifications. 29.1397 Section 29... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Lights § 29.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  14. 14 CFR 27.1397 - Color specifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Color specifications. 27.1397 Section 27... AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Equipment Lights § 27.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  15. 14 CFR 29.1397 - Color specifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Color specifications. 29.1397 Section 29... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Lights § 29.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  16. 14 CFR 23.1397 - Color specifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Color specifications. 23.1397 Section 23.1397 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... Color specifications. Each position light color must have the applicable International Commission...

  17. 14 CFR 27.1397 - Color specifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Color specifications. 27.1397 Section 27... AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Equipment Lights § 27.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  18. 14 CFR 25.1397 - Color specifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Color specifications. 25.1397 Section 25... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Equipment Lights § 25.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  19. 14 CFR 25.1397 - Color specifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Color specifications. 25.1397 Section 25... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Equipment Lights § 25.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  20. 14 CFR 23.1397 - Color specifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Color specifications. 23.1397 Section 23.1397 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... Color specifications. Each position light color must have the applicable International Commission...

  1. 14 CFR 23.1397 - Color specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Color specifications. 23.1397 Section 23.1397 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... Color specifications. Each position light color must have the applicable International Commission...

  2. 14 CFR 23.1397 - Color specifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Color specifications. 23.1397 Section 23.1397 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... Color specifications. Each position light color must have the applicable International Commission...

  3. 14 CFR 27.1397 - Color specifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Color specifications. 27.1397 Section 27... AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Equipment Lights § 27.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  4. 14 CFR 27.1397 - Color specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Color specifications. 27.1397 Section 27... AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Equipment Lights § 27.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  5. 14 CFR 29.1397 - Color specifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Color specifications. 29.1397 Section 29... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Lights § 29.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  6. 43 CFR 3861.2 - Surveys: Specific.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Surveys: Specific. 3861.2 Section 3861.2..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL PATENT APPLICATIONS Surveys and Plats § 3861.2 Surveys: Specific....

  7. 43 CFR 3861.2 - Surveys: Specific.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Surveys: Specific. 3861.2 Section 3861.2..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL PATENT APPLICATIONS Surveys and Plats § 3861.2 Surveys: Specific....

  8. 43 CFR 3861.2 - Surveys: Specific.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Surveys: Specific. 3861.2 Section 3861.2..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL PATENT APPLICATIONS Surveys and Plats § 3861.2 Surveys: Specific....

  9. 43 CFR 3861.2 - Surveys: Specific.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Surveys: Specific. 3861.2 Section 3861.2..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL PATENT APPLICATIONS Surveys and Plats § 3861.2 Surveys: Specific....

  10. 10 CFR 55.11 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Specific exemptions. 55.11 Section 55.11 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES Exemptions § 55.11 Specific exemptions. The Commission may, upon application by an interested person, or upon its own initiative, grant such exemptions...

  11. 10 CFR 63.43 - License specification.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false License specification. 63.43 Section 63.43 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses License Issuance and Amendment § 63.43 License specification. (a) A...

  12. 10 CFR 63.43 - License specification.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false License specification. 63.43 Section 63.43 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses License Issuance and Amendment § 63.43 License specification. (a) A...

  13. 10 CFR 63.43 - License specification.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false License specification. 63.43 Section 63.43 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses License Issuance and Amendment § 63.43 License specification. (a) A...

  14. 10 CFR 63.43 - License specification.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false License specification. 63.43 Section 63.43 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses License Issuance and Amendment § 63.43 License specification. (a) A...

  15. 10 CFR 63.43 - License specification.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false License specification. 63.43 Section 63.43 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses License Issuance and Amendment § 63.43 License specification. (a) A...

  16. 21 CFR 1230.21 - Specific guaranty.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... FEDERAL CAUSTIC POISON ACT Guaranty § 1230.21 Specific guaranty. If a guaranty in respect to any specific... Caustic Poison Act. (Signature and address of guarantor) (b) Substances for other than household use (this... be misbranded within the meaning of the Federal Caustic Poison Act. (Name and address of...

  17. 21 CFR 1230.21 - Specific guaranty.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... FEDERAL CAUSTIC POISON ACT Guaranty § 1230.21 Specific guaranty. If a guaranty in respect to any specific... Caustic Poison Act. (Signature and address of guarantor) (b) Substances for other than household use (this... be misbranded within the meaning of the Federal Caustic Poison Act. (Name and address of...

  18. 21 CFR 1230.21 - Specific guaranty.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... FEDERAL CAUSTIC POISON ACT Guaranty § 1230.21 Specific guaranty. If a guaranty in respect to any specific... Caustic Poison Act. (Signature and address of guarantor) (b) Substances for other than household use (this... be misbranded within the meaning of the Federal Caustic Poison Act. (Name and address of...

  19. 21 CFR 1230.21 - Specific guaranty.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... FEDERAL CAUSTIC POISON ACT Guaranty § 1230.21 Specific guaranty. If a guaranty in respect to any specific... Caustic Poison Act. (Signature and address of guarantor) (b) Substances for other than household use (this... be misbranded within the meaning of the Federal Caustic Poison Act. (Name and address of...

  20. 21 CFR 1230.21 - Specific guaranty.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... FEDERAL CAUSTIC POISON ACT Guaranty § 1230.21 Specific guaranty. If a guaranty in respect to any specific... Caustic Poison Act. (Signature and address of guarantor) (b) Substances for other than household use (this... be misbranded within the meaning of the Federal Caustic Poison Act. (Name and address of...

  1. 10 CFR 140.8 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Specific exemptions. 140.8 Section 140.8 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) FINANCIAL PROTECTION REQUIREMENTS AND INDEMNITY AGREEMENTS General Provisions § 140.8 Specific exemptions. The Commission may, upon application of any interested person or...

  2. 28 CFR 0.101 - Specific functions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Specific functions. 0.101 Section 0.101 Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE Drug Enforcement Administration § 0.101 Specific functions. The Administrator of the Drug Enforcement Administration shall...

  3. 32 CFR 1801.63 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Specific exemptions. 1801.63 Section 1801.63 National Defense Other Regulations Relating to National Defense NATIONAL COUNTERINTELLIGENCE CENTER PUBLIC RIGHTS UNDER THE PRIVACY ACT OF 1974 Exemptions § 1801.63 Specific exemptions. Pursuant to...

  4. 32 CFR 1801.63 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Specific exemptions. 1801.63 Section 1801.63 National Defense Other Regulations Relating to National Defense NATIONAL COUNTERINTELLIGENCE CENTER PUBLIC RIGHTS UNDER THE PRIVACY ACT OF 1974 Exemptions § 1801.63 Specific exemptions. Pursuant to...

  5. 32 CFR 1801.63 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 6 2012-07-01 2012-07-01 false Specific exemptions. 1801.63 Section 1801.63 National Defense Other Regulations Relating to National Defense NATIONAL COUNTERINTELLIGENCE CENTER PUBLIC RIGHTS UNDER THE PRIVACY ACT OF 1974 Exemptions § 1801.63 Specific exemptions. Pursuant to...

  6. 32 CFR 1801.63 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 6 2014-07-01 2014-07-01 false Specific exemptions. 1801.63 Section 1801.63 National Defense Other Regulations Relating to National Defense NATIONAL COUNTERINTELLIGENCE CENTER PUBLIC RIGHTS UNDER THE PRIVACY ACT OF 1974 Exemptions § 1801.63 Specific exemptions. Pursuant to...

  7. 32 CFR 1801.63 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Specific exemptions. 1801.63 Section 1801.63 National Defense Other Regulations Relating to National Defense NATIONAL COUNTERINTELLIGENCE CENTER PUBLIC RIGHTS UNDER THE PRIVACY ACT OF 1974 Exemptions § 1801.63 Specific exemptions. Pursuant to...

  8. 14 CFR 398.3 - Specific airports.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Specific airports. 398.3 Section 398.3... STATEMENTS GUIDELINES FOR INDIVIDUAL DETERMINATIONS OF BASIC ESSENTIAL AIR SERVICE § 398.3 Specific airports. (a) At an eligible place, essential air service may be specified as service to a particular...

  9. 14 CFR 398.3 - Specific airports.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Specific airports. 398.3 Section 398.3... STATEMENTS GUIDELINES FOR INDIVIDUAL DETERMINATIONS OF BASIC ESSENTIAL AIR SERVICE § 398.3 Specific airports. (a) At an eligible place, essential air service may be specified as service to a particular...

  10. 16 CFR 1014.12 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Specific exemptions. 1014.12 Section 1014.12 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL POLICIES AND PROCEDURES IMPLEMENTING THE PRIVACY ACT OF 1974 § 1014.12 Specific exemptions. (a) Injury information. (1) The Bureau of...

  11. 14 CFR 91.1015 - Management specifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Management specifications. 91.1015 Section... Operations Program Management § 91.1015 Management specifications. (a) Each person conducting operations under this subpart or furnishing fractional ownership program management services to fractional...

  12. 14 CFR 91.1015 - Management specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Management specifications. 91.1015 Section... Operations Program Management § 91.1015 Management specifications. (a) Each person conducting operations under this subpart or furnishing fractional ownership program management services to fractional...

  13. Specificity of a Maximal Step Exercise Test

    ERIC Educational Resources Information Center

    Darby, Lynn A.; Marsh, Jennifer L.; Shewokis, Patricia A.; Pohlman, Roberta L.

    2007-01-01

    To adhere to the principle of "exercise specificity" exercise testing should be completed using the same physical activity that is performed during exercise training. The present study was designed to assess whether aerobic step exercisers have a greater maximal oxygen consumption (max VO sub 2) when tested using an activity specific, maximal step…

  14. 10 CFR 725.7 - Specific waivers.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Specific waivers. 725.7 Section 725.7 Energy DEPARTMENT OF ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA General Provisions § 725.7 Specific waivers. The Chief... from the requirements of this part as he determines are authorized by law and will not constitute...

  15. 10 CFR 1016.6 - Specific waivers.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Specific waivers. 1016.6 Section 1016.6 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) SAFEGUARDING OF RESTRICTED DATA General Provisions § 1016.6 Specific... this part as it determines are authorized by law and will not constitute an undue risk to the...

  16. 14 CFR 91.1015 - Management specifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Management specifications. 91.1015 Section... Operations Program Management § 91.1015 Management specifications. (a) Each person conducting operations under this subpart or furnishing fractional ownership program management services to fractional...

  17. 14 CFR 91.1015 - Management specifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Management specifications. 91.1015 Section... Operations Program Management § 91.1015 Management specifications. (a) Each person conducting operations under this subpart or furnishing fractional ownership program management services to fractional...

  18. 14 CFR 91.1015 - Management specifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Management specifications. 91.1015 Section... Operations Program Management § 91.1015 Management specifications. (a) Each person conducting operations under this subpart or furnishing fractional ownership program management services to fractional...

  19. 46 CFR 173.070 - Specific applicability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Specific applicability. 173.070 Section 173.070 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO VESSEL USE Oceanographic Research § 173.070 Specific applicability. Each oceanographic...

  20. 46 CFR 173.070 - Specific applicability.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Specific applicability. 173.070 Section 173.070 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO VESSEL USE Oceanographic Research § 173.070 Specific applicability. Each oceanographic...

  1. 50 CFR 648.260 - Specifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., DEPARTMENT OF COMMERCE FISHERIES OF THE NORTHEASTERN UNITED STATES Management Measures for the Atlantic Deep-Sea Red Crab Fishery § 648.260 Specifications. (a) Annual review and specifications process. The... of stock size; sea sampling, port sampling, and survey data or, if sea sampling data are...

  2. 50 CFR 648.260 - Specifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., DEPARTMENT OF COMMERCE FISHERIES OF THE NORTHEASTERN UNITED STATES Management Measures for the Atlantic Deep-Sea Red Crab Fishery § 648.260 Specifications. (a) Annual review and specifications process. The...; sea sampling, port sampling, and survey data or, if sea sampling data are unavailable,...

  3. 10 CFR 76.23 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Specific exemptions. 76.23 Section 76.23 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS General Provisions § 76.23 Specific exemptions. The Commission may, upon its own initiative or upon application of the...

  4. 10 CFR 76.23 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Specific exemptions. 76.23 Section 76.23 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS General Provisions § 76.23 Specific exemptions. The Commission may, upon its own initiative or upon application of the...

  5. 10 CFR 76.23 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Specific exemptions. 76.23 Section 76.23 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS General Provisions § 76.23 Specific exemptions. The Commission may, upon its own initiative or upon application of the...

  6. 10 CFR 76.23 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Specific exemptions. 76.23 Section 76.23 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS General Provisions § 76.23 Specific exemptions. The Commission may, upon its own initiative or upon application of the...

  7. 10 CFR 76.23 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Specific exemptions. 76.23 Section 76.23 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS General Provisions § 76.23 Specific exemptions. The Commission may, upon its own initiative or upon application of the...

  8. 46 CFR 171.130 - Specific applicability.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Specific applicability. 171.130 Section 171.130 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO VESSELS CARRYING PASSENGERS Drainage of Weather Decks § 171.130 Specific applicability....

  9. 46 CFR 171.130 - Specific applicability.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Specific applicability. 171.130 Section 171.130 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO VESSELS CARRYING PASSENGERS Drainage of Weather Decks § 171.130 Specific applicability....

  10. 46 CFR 171.130 - Specific applicability.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Specific applicability. 171.130 Section 171.130 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO VESSELS CARRYING PASSENGERS Drainage of Weather Decks § 171.130 Specific applicability....

  11. 46 CFR 171.130 - Specific applicability.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Specific applicability. 171.130 Section 171.130 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO VESSELS CARRYING PASSENGERS Drainage of Weather Decks § 171.130 Specific applicability....

  12. 46 CFR 171.130 - Specific applicability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Specific applicability. 171.130 Section 171.130 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO VESSELS CARRYING PASSENGERS Drainage of Weather Decks § 171.130 Specific applicability....

  13. 46 CFR 170.160 - Specific applicability

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Specific applicability 170.160 Section 170.160 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY STABILITY REQUIREMENTS FOR ALL INSPECTED VESSELS Weather Criteria § 170.160 Specific applicability (a) Except as...

  14. Fast specific field detection of RHDVb.

    PubMed

    Dalton, K P; Nicieza, I; Podadera, A; de Llano, D; Martin Alonso, J M; de Los Toyos, J R; García Ocaña, M; Vázquez-Villa, F; Velasco, B; Landeta, O; Parra, F

    2017-02-28

    This work describes a simple and rapid test for field detection of the emerging rabbit pathogen RHDVb. The assay is specific for RHDVb, showing no cross-reactivity with other RHDV types giving a specific result in under 10 min using rabbit liquid exudates or liver homogenate samples taken at necropsy.

  15. 10 CFR 55.11 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Specific exemptions. 55.11 Section 55.11 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES Exemptions § 55.11 Specific exemptions. The Commission may, upon application by an interested person, or upon its own initiative, grant such exemptions...

  16. 324 and 327 Facilities Environmental Effluent Specifications

    SciTech Connect

    JOHNSON, D.L.

    1999-08-30

    These effluent specifications address requirements for the 324/321 Facilities, which are undergoing stabilization activities. Effluent specifications are imposed to protect personnel, the environment and the public, by ensuring adequate implementation and compliance with federal and state regulatory requirements and Hanford programs.

  17. Identifying Specific Comprehension Deficits in Children

    ERIC Educational Resources Information Center

    Gifford, Diane Baty

    2013-01-01

    Research has shown that educators may be missing an under-identified population of approximately 10 percent of typically developing children, who have fluent, age-appropriate decoding and word recognition skills, yet have specific difficulties with other higher-level text processing factors. These children are said to have specific comprehension…

  18. 50 CFR 648.294 - Framework specifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Framework specifications. 648.294 Section... Tilefish Fishery § 648.294 Framework specifications. Link to an amendment published at 76 FR 60645, Sept... management measures may be adjusted at any time through the framework process: (i) Minimum fish size;...

  19. 50 CFR 648.165 - Framework specifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Framework specifications. 648.165 Section... Atlantic Bluefish Fishery § 648.165 Framework specifications. Link to an amendment published at 76 FR 60641... through its annual review or framework adjustment process that minimum fish sizes are necessary to...

  20. 10 CFR 35.19 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Specific exemptions. 35.19 Section 35.19 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL General Information § 35.19 Specific exemptions. The Commission may, upon application of any interested person or upon its own initiative, grant exemptions...

  1. 10 CFR 35.19 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Specific exemptions. 35.19 Section 35.19 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL General Information § 35.19 Specific exemptions. The Commission may, upon application of any interested person or upon its own initiative, grant exemptions...

  2. 10 CFR 35.19 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Specific exemptions. 35.19 Section 35.19 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL General Information § 35.19 Specific exemptions. The Commission may, upon application of any interested person or upon its own initiative, grant exemptions...

  3. 10 CFR 35.19 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Specific exemptions. 35.19 Section 35.19 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL General Information § 35.19 Specific exemptions. The Commission may, upon application of any interested person or upon its own initiative, grant exemptions...

  4. 10 CFR 35.19 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Specific exemptions. 35.19 Section 35.19 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL General Information § 35.19 Specific exemptions. The Commission may, upon application of any interested person or upon its own initiative, grant exemptions...

  5. 40 CFR 86.1513 - Fuel specifications.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 19 2011-07-01 2011-07-01 false Fuel specifications. 86.1513 Section 86.1513 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... § 86.1513 Fuel specifications. The requirements of this section are set forth in 40 CFR part...

  6. 40 CFR 92.113 - Fuel specifications.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 20 2011-07-01 2011-07-01 false Fuel specifications. 92.113 Section 92...) CONTROL OF AIR POLLUTION FROM LOCOMOTIVES AND LOCOMOTIVE ENGINES Test Procedures § 92.113 Fuel specifications. (a) Diesel test fuel. (1) The diesel fuels for testing locomotives or locomotive engines...

  7. 40 CFR 92.113 - Fuel specifications.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 21 2012-07-01 2012-07-01 false Fuel specifications. 92.113 Section 92...) CONTROL OF AIR POLLUTION FROM LOCOMOTIVES AND LOCOMOTIVE ENGINES Test Procedures § 92.113 Fuel specifications. (a) Diesel test fuel. (1) The diesel fuels for testing locomotives or locomotive engines...

  8. 40 CFR 86.1513 - Fuel specifications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 19 2010-07-01 2010-07-01 false Fuel specifications. 86.1513 Section 86.1513 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... § 86.1513 Fuel specifications. The requirements of this section are set forth in 40 CFR part...

  9. 40 CFR 86.1513 - Fuel specifications.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 20 2013-07-01 2013-07-01 false Fuel specifications. 86.1513 Section 86.1513 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... § 86.1513 Fuel specifications. The requirements of this section are set forth in 40 CFR part...

  10. 40 CFR 92.113 - Fuel specifications.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 20 2014-07-01 2013-07-01 true Fuel specifications. 92.113 Section 92...) CONTROL OF AIR POLLUTION FROM LOCOMOTIVES AND LOCOMOTIVE ENGINES Test Procedures § 92.113 Fuel specifications. (a) Diesel test fuel. (1) The diesel fuels for testing locomotives or locomotive engines...

  11. 40 CFR 92.113 - Fuel specifications.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 21 2013-07-01 2013-07-01 false Fuel specifications. 92.113 Section 92...) CONTROL OF AIR POLLUTION FROM LOCOMOTIVES AND LOCOMOTIVE ENGINES Test Procedures § 92.113 Fuel specifications. (a) Diesel test fuel. (1) The diesel fuels for testing locomotives or locomotive engines...

  12. 40 CFR 86.1513 - Fuel specifications.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 20 2012-07-01 2012-07-01 false Fuel specifications. 86.1513 Section 86.1513 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... § 86.1513 Fuel specifications. The requirements of this section are set forth in 40 CFR part...

  13. 40 CFR 92.113 - Fuel specifications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Fuel specifications. 92.113 Section 92...) CONTROL OF AIR POLLUTION FROM LOCOMOTIVES AND LOCOMOTIVE ENGINES Test Procedures § 92.113 Fuel specifications. (a) Diesel test fuel. (1) The diesel fuels for testing locomotives or locomotive engines...

  14. Formalisms for user interface specification and design

    NASA Technical Reports Server (NTRS)

    Auernheimer, Brent J.

    1989-01-01

    The application of formal methods to the specification and design of human-computer interfaces is described. A broad outline of human-computer interface problems, a description of the field of cognitive engineering and two relevant research results, the appropriateness of formal specification techniques, and potential NASA application areas are described.

  15. General specifications covering requirements of aeronautic instruments

    NASA Technical Reports Server (NTRS)

    1917-01-01

    Report includes specifications for the use and production of instruments used in the navigation and operation of aircraft. Specifications are included for the following instruments: barometer or altimeter, compass, air speed meter, inclinometer, drift meter, tachometer, oil gauge, oil pressure gauge, gasoline gauge, gasoline flow indicator, distance indicator, barograph, angle of attack indicator, radiator temperature indicator, gasoline feed system pressure indicator, sextant, airplane director.

  16. 10 CFR 51.6 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Specific exemptions. 51.6 Section 51.6 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR DOMESTIC LICENSING AND RELATED REGULATORY FUNCTIONS § 51.6 Specific exemptions. The Commission may, upon application of any...

  17. 10 CFR 51.6 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Specific exemptions. 51.6 Section 51.6 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR DOMESTIC LICENSING AND RELATED REGULATORY FUNCTIONS § 51.6 Specific exemptions. The Commission may, upon application of any...

  18. 10 CFR 71.12 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Specific exemptions. 71.12 Section 71.12 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PACKAGING AND TRANSPORTATION OF RADIOACTIVE MATERIAL Exemptions § 71.12 Specific exemptions. On application of any interested person or on its own initiative, the Commission...

  19. 10 CFR 26.9 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Specific exemptions. 26.9 Section 26.9 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.9 Specific exemptions. Upon application of any interested person or on its own initiative, the Commission may grant such exemptions...

  20. 10 CFR 26.9 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Specific exemptions. 26.9 Section 26.9 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.9 Specific exemptions. Upon application of any interested person or on its own initiative, the Commission may grant such exemptions...

  1. 10 CFR 26.9 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Specific exemptions. 26.9 Section 26.9 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.9 Specific exemptions. Upon application of any interested person or on its own initiative, the Commission may grant such exemptions...

  2. 10 CFR 26.9 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Specific exemptions. 26.9 Section 26.9 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.9 Specific exemptions. Upon application of any interested person or on its own initiative, the Commission may grant such exemptions...

  3. 10 CFR 26.9 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Specific exemptions. 26.9 Section 26.9 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.9 Specific exemptions. Upon application of any interested person or on its own initiative, the Commission may grant such exemptions...

  4. 50 CFR 660.508 - Annual specifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Annual specifications. 660.508 Section 660.508 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 660.508 Annual specifications. (a) The Regional Administrator will determine the harvest guidelines...

  5. 50 CFR 660.508 - Annual specifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Annual specifications. 660.508 Section 660.508 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 660.508 Annual specifications. (a) The Regional Administrator will determine any harvest...

  6. 18 CFR 35.33 - Specific provisions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Specific provisions. 35.33 Section 35.33 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... Governing Nuclear Plant Decommissioning Trust Funds § 35.33 Specific provisions. (a) In addition to...

  7. 18 CFR 35.33 - Specific provisions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Specific provisions. 35.33 Section 35.33 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... Governing Nuclear Plant Decommissioning Trust Funds § 35.33 Specific provisions. (a) In addition to...

  8. 18 CFR 35.33 - Specific provisions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Specific provisions. 35.33 Section 35.33 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... Governing Nuclear Plant Decommissioning Trust Funds § 35.33 Specific provisions. (a) In addition to...

  9. 18 CFR 35.33 - Specific provisions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Specific provisions. 35.33 Section 35.33 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... Governing Nuclear Plant Decommissioning Trust Funds § 35.33 Specific provisions. (a) In addition to...

  10. 18 CFR 35.33 - Specific provisions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Specific provisions. 35.33 Section 35.33 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... Governing Nuclear Plant Decommissioning Trust Funds § 35.33 Specific provisions. (a) In addition to...

  11. 14 CFR 119.7 - Operations specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Operations specifications. 119.7 Section...) AIR CARRIERS AND OPERATORS FOR COMPENSATION OR HIRE: CERTIFICATION AND OPERATIONS CERTIFICATION: AIR CARRIERS AND COMMERCIAL OPERATORS General § 119.7 Operations specifications. (a) Each certificate...

  12. 48 CFR 2919.202 - Specific policies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Specific policies. 2919.202 Section 2919.202 Federal Acquisition Regulations System DEPARTMENT OF LABOR SOCIOECONOMIC PROGRAMS SMALL BUSINESS AND SMALL DISADVANTAGED BUSINESS CONCERNS Policies 2919.202 Specific...

  13. In Situ Vitrification software requirements specification

    SciTech Connect

    Grush, W.H.; Marwil, E.S.

    1990-09-01

    This report describes the Software Requirements Specification for the Electrical Resistance Heating and Thermal Energy Transport models of the In-Situ Vitrification (ISV) process. It contains the Data Flow Diagrams, Process Specifications, Data Structure Diagrams, and the Data Dictionary. 5 refs.

  14. 32 CFR 292.4 - Specific policy.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false Specific policy. 292.4 Section 292.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM OF INFORMATION ACT PROGRAM DEFENSE INTELLIGENCE AGENCY (DIA) FREEDOM OF INFORMATION ACT § 292.4 Specific...

  15. Stress and Specificity: Reply to Miller (2009)

    ERIC Educational Resources Information Center

    Denson, Thomas F.; Spanovic, Marija; Miller, Norman

    2009-01-01

    T. F. Denson, M. Spanovic, and N. Miller (2009) meta-analytically tested the hypotheses that specific appraisals and emotions would predict cortisol and immune responses to laboratory stressors and emotion inductions. Although the cortisol data supported the integrated specificity hypothesis, G. E. Miller (2009) raised questions concerning the…

  16. Selection of Children with Specific Language Deficits.

    ERIC Educational Resources Information Center

    Stark, Rachel E.; Tallal, Paula

    1981-01-01

    A standard approach to the selection of children with specific language deficits was devised, based on a current definition of specific language deficit that depends heavily on exclusion criteria. A total of 132 language impaired children aged four to eight and one-half years were assessed. (Author)

  17. 29 CFR 1956.10 - Specific criteria.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... GOVERNMENT EMPLOYEES IN STATES WITHOUT APPROVED PRIVATE EMPLOYEE PLANS Criteria § 1956.10 Specific criteria. (a) General. A State plan for public employees must meet the specific criteria set forth in this... required by the Assistant Secretary. (c) Standards. The State plan for public employees shall include,...

  18. Plutonium Immobilization Can Loading Preliminary Specifications

    SciTech Connect

    Kriikku, E.

    1998-11-25

    This report discusses the Plutonium Immobilization can loading preliminary equipment specifications and includes a process block diagram, process description, equipment list, preliminary equipment specifications, plan and elevation sketches, and some commercial catalogs. This report identifies loading pucks into cans and backfilling cans with helium as the top priority can loading development areas.

  19. 10 CFR 54.15 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Specific exemptions. 54.15 Section 54.15 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) REQUIREMENTS FOR RENEWAL OF OPERATING LICENSES FOR NUCLEAR POWER PLANTS General Provisions § 54.15 Specific exemptions. Exemptions from the requirements of this part may...

  20. 10 CFR 74.7 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Specific exemptions. 74.7 Section 74.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) MATERIAL CONTROL AND ACCOUNTING OF SPECIAL NUCLEAR MATERIAL General Provisions § 74.7 Specific exemptions. The Commission may, upon application of any interested person or...

  1. 5 CFR 2100.13 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 3 2012-01-01 2012-01-01 false Specific exemptions. 2100.13 Section 2100.13 Administrative Personnel ARMED FORCES RETIREMENT HOME ARMED FORCES RETIREMENT HOME PRIVACY ACT PROCEDURES § 2100.13 Specific exemptions. Subsection (k) of 5 U.S.C. 552a authorizes the AFRH to adopt...

  2. 5 CFR 2100.13 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 3 2011-01-01 2011-01-01 false Specific exemptions. 2100.13 Section 2100.13 Administrative Personnel ARMED FORCES RETIREMENT HOME ARMED FORCES RETIREMENT HOME PRIVACY ACT PROCEDURES § 2100.13 Specific exemptions. Subsection (k) of 5 U.S.C. 552a authorizes the AFRH to adopt...

  3. 5 CFR 2100.13 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 3 2014-01-01 2014-01-01 false Specific exemptions. 2100.13 Section 2100.13 Administrative Personnel ARMED FORCES RETIREMENT HOME ARMED FORCES RETIREMENT HOME PRIVACY ACT PROCEDURES § 2100.13 Specific exemptions. Subsection (k) of 5 U.S.C. 552a authorizes the AFRH to adopt...

  4. Situation-Specific Assessment of Sexual Harassment.

    ERIC Educational Resources Information Center

    Mazzeo, Suzanne E.; Bergman, Mindy E.; Buchanan, NiCole T.; Drasgow, Fritz; Fitzgerald, Louise F.

    2001-01-01

    A survey of 13,743 women in the armed forces used an instrument to identify specific experiences of sexual harassment rather than aggregate approaches. Confirmatory factor analysis supported the measure's construct validity. Reasons for using aggregate versus situation-specific approaches were identified. (Contains 19 references.) (SK)

  5. 5 CFR 2100.13 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Specific exemptions. 2100.13 Section 2100.13 Administrative Personnel ARMED FORCES RETIREMENT HOME ARMED FORCES RETIREMENT HOME PRIVACY ACT PROCEDURES § 2100.13 Specific exemptions. Subsection (k) of 5 U.S.C. 552a authorizes the AFRH to adopt...

  6. 5 CFR 2100.13 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false Specific exemptions. 2100.13 Section 2100.13 Administrative Personnel ARMED FORCES RETIREMENT HOME ARMED FORCES RETIREMENT HOME PRIVACY ACT PROCEDURES § 2100.13 Specific exemptions. Subsection (k) of 5 U.S.C. 552a authorizes the AFRH to adopt...

  7. 10 CFR 11.9 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Specific exemptions. 11.9 Section 11.9 Energy NUCLEAR... SPECIAL NUCLEAR MATERIAL General Provisions § 11.9 Specific exemptions. The Commission may, upon... granted only if they are authorized by law and will not constitute an undue risk to the common defense...

  8. Structured representation for requirements and specifications

    NASA Technical Reports Server (NTRS)

    Cohen, Gerald C.; Fisher, Gene; Frincke, Deborah; Wolber, Dave

    1991-01-01

    This document was generated in support of NASA contract NAS1-18586, Design and Validation of Digital Flight Control Systems suitable for Fly-By-Wire Applications, Task Assignment 2. Task 2 is associated with a formal representation of requirements and specifications. In particular, this document contains results associated with the development of a Wide-Spectrum Requirements Specification Language (WSRSL) that can be used to express system requirements and specifications in both stylized and formal forms. Included with this development are prototype tools to support the specification language. In addition a preliminary requirements specification methodology based on the WSRSL has been developed. Lastly, the methodology has been applied to an Advanced Subsonic Civil Transport Flight Control System.

  9. Specificity of marine microbial surface interactions.

    PubMed Central

    Imam, S H; Bard, R F; Tosteson, T R

    1984-01-01

    The macromolecular surface components involved in intraspecific cell surface interactions of the green microalga Chlorella vulgaris and closely associated bacteria were investigated. The specific surface attachment between this alga and its associated bacteria is mediated by lectin-like macromolecules associated with the surfaces of these cells. The binding activity of these surface polymers was inhibited by specific simple sugars; this suggests the involvement of specific receptor-ligand binding sites on the interactive surfaces. Epifluorescent microscopic evaluation of bacteria-alga interactions in the presence and absence of the macromolecules that mediate these interactions showed that the glycoproteins active in these processes were specific to the microbial sources from which they were obtained. The demonstration and definition of the specificity of these interactions in mixed microbial populations may play an important role in our understanding of the dynamics of marine microbial populations in the sea. PMID:6508293

  10. Improvements to Technical Specifications surveillance requirements

    SciTech Connect

    Lobel, R.; Tjader, T.R.

    1992-12-01

    In August 1983 an NRC task group was formed to investigate problems with surveillance testing required by Technical Specifications, and to recommend approaches to effect improvements. NUREG-1024 ( Technical Specifications-Enhancing Safety Impact'') resulted, and it contained recommendations to review the basis for test frequencies; to ensure that the tests promote safety and do not degrade equipment; and to review surveillance tests so that they do not unnecessarily burden personnel. The Technical Specifications Improvement Program (TSIP) was established in December 1984 to provide the framework for rewriting and improving the Technical Specifications. As an element of the TSIP, all Technical Specifications surveillance requirements were comprehensively examined as recommended in NUREG-1024. The results of that effort are presented in this report. The study found that while some testing at power is essential to verify equipment and system operability, safety can be improved, equipment degradation decreased, and unnecessary personnel burden relaxed by reducing the amount of testing at power.

  11. On the Specificity of Adaptive Mutations

    PubMed Central

    Hall, B. G.

    1997-01-01

    Adaptive mutations are mutations that occur in nondividing or slowly dividing cells during prolonged nonlethal selection, and that appear to be specific to the challenge of the selection in the sense that the only mutations that arise are those that provide a growth advantage to the cell. The issue of the specificity has been controversial because it violates our most basic assumptions about the randomness of mutations with respect to their effect on the cell. Although a variety of experiments in several systems in both bacteria and yeast have claimed to demonstrate that specificity, those experiments have been subjected to a variety of technical criticisms suggesting that the specificity may not be real. Here I use the ebg system to provide evidence that when selection is applied to one specific nucleotide site within a gene, mutation occurs at that site but not at an alternative and equally mutable site within the same gene. PMID:9017388

  12. Breckinridge Project, initial effort. Report III, Volume 2. Specifications

    SciTech Connect

    1982-01-01

    Report III, Volume 2 contains those specifications numbered K through Y, as follows: Specifications for Compressors (K); Specifications for Piping (L); Specifications for Structures (M); Specifications for Insulation (N); Specifications for Electrical (P); Specifications for Concrete (Q); Specifications for Civil (S); Specifications for Welding (W); Specifications for Painting (X); and Specifications for Special (Y). The standard specifications of Bechtel Petroleum Incorporated have been amended as necessary to reflect the specific requirements of the Breckinridge Project and the more stringent specifications of Ashland Synthetic Fuels, Inc. These standard specifications are available for the Initial Effort (Phase Zero) work performed by all contractors and subcontractors.

  13. The classic cadherins in synaptic specificity

    PubMed Central

    Basu, Raunak; Taylor, Matthew R; Williams, Megan E

    2015-01-01

    During brain development, billions of neurons organize into highly specific circuits. To form specific circuits, neurons must build the appropriate types of synapses with appropriate types of synaptic partners while avoiding incorrect partners in a dense cellular environment. Defining the cellular and molecular rules that govern specific circuit formation has significant scientific and clinical relevance because fine scale connectivity defects are thought to underlie many cognitive and psychiatric disorders. Organizing specific neural circuits is an enormously complicated developmental process that requires the concerted action of many molecules, neural activity, and temporal events. This review focuses on one class of molecules postulated to play an important role in target selection and specific synapse formation: the classic cadherins. Cadherins have a well-established role in epithelial cell adhesion, and although it has long been appreciated that most cadherins are expressed in the brain, their role in synaptic specificity is just beginning to be unraveled. Here, we review past and present studies implicating cadherins as active participants in the formation, function, and dysfunction of specific neural circuits and pose some of the major remaining questions. PMID:25837840

  14. Constructing specifications by combining parallel elaborations

    SciTech Connect

    Feather, M.S.

    1989-02-01

    Constructing specifications of complex tasks is often a laborious activity in spite of the rich vocabulary provided by specification languages. An incremental approach to construction is proposed, with the virtue of offering considerable opportunity for mechanized support. Following this approach one builds a specification through a series of elaborations that incrementally adjust a simple initial specification. Elaborations perform both refinements, adding further detail, and adaptations, retracting oversimplifications and tailoring approximations to the specifics of the task. It is anticipated that the vast majority of elaborations can be concisely described to a mechanism which will then perform them automatically. When elaborations are independent, they can be applied in parallel, leading to diverging specifications which must later be recombined. The approach is intended to facilitate comprehension and maintenance of specifications, as well as their initial construction. The advantages of following this approach stem from the gradual nature of the elaboration process, the separation of concerns through following independent elaborations in parallel, the simplicity of the individual elaboration steps (the effects of each step are well delineated), and the availability of an explicit record of construction.

  15. Cell specific, variable density, polymer microspheres

    NASA Technical Reports Server (NTRS)

    Yen, Shiao-Ping S. (Inventor); Rembaum, Alan (Inventor); Molday, Robert S. (Inventor)

    1977-01-01

    Biocompatible polymeric microspheres having an average diameter below about 3 microns and having density at least 15% greater or lesser than organic cells and having covalent binding sites are provided in accordance with this invention. The microspheres are obtained by copolymerizing a hydroxy or amine substituted acrylic monomer such as hydroxyethylmethacrylate with a light or dense comonomer such as a fluoromonomer. A lectin or antibody is bound to the hydroxy or amine site of the bead to provide cell specificity. When added to a cell suspension the marked bead will specifically label the cell membrane by binding to specific receptor sites thereon. The labelled membrane can then be separated by density gradient centrifugation.

  16. Tissue-specific circadian clocks in plants.

    PubMed

    Endo, Motomu

    2016-02-01

    Circadian clocks affect a large proportion of differentially expressed genes in many organisms. Tissue-specific hierarchies in circadian networks in mammals have been contentiously debated, whereas little attention has been devoted to the concept in plants, owing to technical difficulties. Recently, several studies have demonstrated tissue-specific circadian clocks and their coupling in plants, suggesting that plants possess a hierarchical network of circadian clocks. The following review summarizes recent studies describing the tissue-specific functions and properties of these circadian clocks and discusses the network structure and potential messengers that might share temporal information on such a network.

  17. Emergency Medicine Gender-specific Education.

    PubMed

    Ashurst, John V; McGregor, Alyson J; Safdar, Basmah; Weaver, Kevin R; Quinn, Shawn M; Rosenau, Alex M; Goyke, Terrence E; Roth, Kevin R; Greenberg, Marna R

    2014-12-01

    The 2014 Academic Emergency Medicine consensus conference has taken the first step in identifying gender-specific care as an area of importance to both emergency medicine (EM) and research. To improve patient care, we need to address educational gaps in this area concurrent with research gaps. In this article, the authors highlight the need for sex- and gender-specific education in EM and propose guidelines for medical student, resident, and faculty education. Specific examples of incorporating this content into grand rounds, simulation, bedside teaching, and journal club sessions are reviewed. Future challenges and strategies to fill the gaps in the current education model are also described.

  18. 60% Review technical specifications, Deaf Smith Site

    SciTech Connect

    Gast, R.A.

    1987-08-01

    The enclosed documentation for the 60% Review Technical Specifications, Deaf Smith Site includes: Solicitation Documents which represent the eventual Federal Acquisition Regulations (FARs) and Department of Energy Acquisition Regulations (DEARs) that will comprise a segment of the contractual documents for bidders attention; Contract Clauses that will become integral parts for the Fixed Price Construction Contracts applicable to the Exploratory Shaft Facility; Special Contract Requirements that will become contract provisions requiring specific contractor attention; Technical Specifications which have been completed for 60% submission, and the current list of 241 Contract Drawings that have been separately forwarded for review and comment.

  19. Specific heat and thermal conductivity of nanomaterials

    NASA Astrophysics Data System (ADS)

    Bhatt, Sandhya; Kumar, Raghuvesh; Kumar, Munish

    2017-01-01

    A model is proposed to study the size and shape effects on specific heat and thermal conductivity of nanomaterials. The formulation developed for specific heat is based on the basic concept of cohesive energy and melting temperature. The specific heat of Ag and Au nanoparticles is reported and the effect of size and shape has been studied. We observed that specific heat increases with the reduction of particle size having maximum shape effect for spherical nanoparticle. To provide a more critical test, we extended our model to study the thermal conductivity and used it for the study of Si, diamond, Cu, Ni, Ar, ZrO2, BaTiO3 and SrTiO3 nanomaterials. A significant reduction is found in the thermal conductivity for nanomaterials by decreasing the size. The model predictions are consistent with the available experimental and simulation results. This demonstrates the suitability of the model proposed in this paper.

  20. Specification For ST-5 Li Ion Battery

    NASA Technical Reports Server (NTRS)

    Castell, Karen D.; Day, John H. (Technical Monitor)

    2000-01-01

    This Specification defines the general requirements for rechargeable Space Flight batteries intended for use in the ST-5 program. The battery chemistry chosen for this mission is lithium ion (Li-Ion).

  1. Evolving concepts of specificity in immune reactions.

    PubMed

    Eisen, Herman N; Chakraborty, Arup K

    2010-12-28

    Our goal is to provide a perspective on current understanding of the origins of specificity in immune reactions, a topic that has intrigued scientists for over a century. A fundamental property of adaptive immune responses is the ability to discriminate among an immense variety of substances by means of antibodies (Abs) and Ab-like receptors on T lymphocytes [T-cell receptors (TCRs)], each able to bind a particular chemical structure [the antigen (Ag)] and not, or only weakly, similar alternatives. Evidence has long existed, however, and has grown, especially recently, that while exhibiting remarkable specificity, many individual Abs and TCRs can also bind a variety of very different ligands. How can Ag recognition by these receptors exercise the great specificity for which they are renowned and yet react with a variety of different ligands (degeneracy)? We critically consider the mechanistic bases for this specificity/degeneracy enigma and also compare and contrast Ag recognition by Abs and TCRs.

  2. Surface cleanliness of fluid systems, specification for

    NASA Technical Reports Server (NTRS)

    1995-01-01

    This specification establishes surface cleanliness levels, test methods, cleaning and packaging requirements, and protection and inspection procedures for determining surface cleanliness. These surfaces pertain to aerospace parts, components, assemblies, subsystems, and systems in contact with any fluid medium.

  3. 32 CFR 292.4 - Specific policy.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... INFORMATION ACT PROGRAM DEFENSE INTELLIGENCE AGENCY (DIA) FREEDOM OF INFORMATION ACT § 292.4 Specific policy... characteristics, made or received by the DIA in connection with the transaction of public business and in the...

  4. Mission specification for three generic mission classes

    NASA Technical Reports Server (NTRS)

    1979-01-01

    Mission specifications for three generic mission classes are generated to provide a baseline for definition and analysis of data acquisition platform system concepts. The mission specifications define compatible groupings of sensors that satisfy specific earth resources and environmental mission objectives. The driving force behind the definition of sensor groupings is mission need; platform and space transportation system constraints are of secondary importance. The three generic mission classes are: (1) low earth orbit sun-synchronous; (2) geosynchronous; and (3) non-sun-synchronous, nongeosynchronous. These missions are chosen to provide a variety of sensor complements and implementation concepts. Each mission specification relates mission categories, mission objectives, measured parameters, and candidate sensors to orbits and coverage, operations compatibility, and platform fleet size.

  5. 16 CFR 1210.15 - Specifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... importer shall ensure that the surrogate lighters used for qualification testing under § 1210.14 are described in a written product specification. (Section 1210.4(c) requires that six surrogate lighters...

  6. 16 CFR 1210.15 - Specifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... importer shall ensure that the surrogate lighters used for qualification testing under § 1210.14 are described in a written product specification. (Section 1210.4(c) requires that six surrogate lighters...

  7. 16 CFR 1210.15 - Specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... importer shall ensure that the surrogate lighters used for qualification testing under § 1210.14 are described in a written product specification. (Section 1210.4(c) requires that six surrogate lighters...

  8. 16 CFR 1210.15 - Specifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... importer shall ensure that the surrogate lighters used for qualification testing under § 1210.14 are described in a written product specification. (Section 1210.4(c) requires that six surrogate lighters...

  9. 16 CFR 1210.15 - Specifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... importer shall ensure that the surrogate lighters used for qualification testing under § 1210.14 are described in a written product specification. (Section 1210.4(c) requires that six surrogate lighters...

  10. 48 CFR 8.712 - Specification changes.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Are Blind or Severely Disabled 8.712 Specification changes. (a) The contracting activity shall notify... concerned at least 90 days prior to the date that any changes in the scope of work or other conditions...

  11. Specific Impulse Definition for Ablative Laser Propulsion

    NASA Technical Reports Server (NTRS)

    Herren, Kenneth A.; Gregory, Don A.

    2004-01-01

    The term "specific impulse" is so ingrained in the field of rocket propulsion that it is unlikely that any fundamental argument would be taken seriously for its removal. It is not an ideal measure but it does give an indication of the amount of mass flow (mass loss/time), as in fuel rate, required to produce a measured thrust over some time period This investigation explores the implications of being able to accurately measure the ablation rate and how the language used to describe the specific impulse results may have to change slightly, and recasts the specific impulse as something that is not a time average. It is not currently possible to measure the ablation rate accurately in real time so it is generally just assumed that a constant amount of material will be removed for each laser pulse delivered The specific impulse dependence on the ablation rate is determined here as a correction to the classical textbook definition.

  12. 48 CFR 36.202 - Specifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... technical societies. (c) When brand name or equal descriptions are necessary, specifications must clearly identify and describe the particular physical, functional, or other characteristics of the brand-name...

  13. Thermodynamic stability contributes to immunoglobulin specificity.

    PubMed

    Dimitrov, Jordan D; Kaveri, Srinivas V; Lacroix-Desmazes, Sébastien

    2014-05-01

    Antigen-binding specificity of immunoglobulins is important for their function in immune defense. However, immune repertoires contain a considerable fraction of immunoglobulins with promiscuous binding behavior, the physicochemical basis of which is not well understood. Evolution of immunoglobulin specificity occurs through iterative processes of mutation and selection, referred to as affinity maturation. Recent studies reveal that some somatic mutations could compromise the thermodynamic stability of the variable regions of immunoglobulins. By integrating this observation with the wealth of data on the evolution of novel enzyme activities, we propose that antibody specificity is linked to the thermodynamic stability of the antigen-binding regions, which provides a quantitative distinction between highly specific and promiscuous antibodies.

  14. Cockpit management and Specific Behavioral Objectives (SBOs)

    NASA Technical Reports Server (NTRS)

    Mudge, R. W.

    1987-01-01

    One of the primary tools used to accomplish the task of effective training is the specific behavioral objective (SBO). An SBO is simply a statement which specifically identifies a small segment of the final behavior sought, and a little more. The key word is specific. The company pinpoints exactly what it is it wants the pilot to do after completing training, and what it should evaluate from the point of view of both the program and the pilot. It tells the junior crewmember exactly, specifically, what he should monitor and support insofar as the management function is concerned. It gives greater meaning to the term second in command. And finally, it tells the supervisory pilot exactly what he should observe, evaluate, and instruct, insofar as the management function is concerned.

  15. 2nd Generation ELT Performance Specification Development

    NASA Technical Reports Server (NTRS)

    Stimson, Chad M.

    2015-01-01

    NASA Search And Rescue is supporting RTCA SC-229 with research and recommendations for performance specifications for the 2nd generation of emergency locator transmitters. Areas for improvement and methods for collecting data will be presented.

  16. Development of simulation computer complex specification

    NASA Technical Reports Server (NTRS)

    1973-01-01

    The Training Simulation Computer Complex Study was one of three studies contracted in support of preparations for procurement of a shuttle mission simulator for shuttle crew training. The subject study was concerned with definition of the software loads to be imposed on the computer complex to be associated with the shuttle mission simulator and the development of procurement specifications based on the resulting computer requirements. These procurement specifications cover the computer hardware and system software as well as the data conversion equipment required to interface the computer to the simulator hardware. The development of the necessary hardware and software specifications required the execution of a number of related tasks which included, (1) simulation software sizing, (2) computer requirements definition, (3) data conversion equipment requirements definition, (4) system software requirements definition, (5) a simulation management plan, (6) a background survey, and (7) preparation of the specifications.

  17. 46 CFR 170.093 - Specific approvals.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Marine Safety Center. These approval determinations will be made as a part of the plan review process. ... REQUIREMENTS FOR ALL INSPECTED VESSELS Plan Approval § 170.093 Specific approvals. Certain rules in...

  18. Slicing AADL Specifications for Model Checking

    NASA Technical Reports Server (NTRS)

    Odenbrett, Maximilian; Nguyen, Viet Yen; Noll, Thomas

    2010-01-01

    To combat the state-space explosion problem in model checking larger systems, abstraction techniques can be employed. Here, methods that operate on the system specification before constructing its state space are preferable to those that try to minimize the resulting transition system as they generally reduce peak memory requirements. We sketch a slicing algorithm for system specifications written in (a variant of) the Architecture Analysis and Design Language (AADL). Given a specification and a property to be verified, it automatically removes those parts of the specification that are irrelevant for model checking the property, thus reducing the size of the corresponding transition system. The applicability and effectiveness of our approach is demonstrated by analyzing the state-space reduction for an example, employing a translator from AADL to Promela, the input language of the SPIN model checker.

  19. Specifications and programs for computer software validation

    NASA Technical Reports Server (NTRS)

    Browne, J. C.; Kleir, R.; Davis, T.; Henneman, M.; Haller, A.; Lasseter, G. L.

    1973-01-01

    Three software products developed during the study are reported and include: (1) FORTRAN Automatic Code Evaluation System, (2) the Specification Language System, and (3) the Array Index Validation System.

  20. 16 CFR 1209.35 - Product specification.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION Certification § 1209.35 Product specification. (a) Requirement. Before any manufacturer, importer, or private labeler distributes in commerce cellulose..., the cellulose insulation may be manufactured and distributed in commerce, subject to the provisions...

  1. Double Shell Tank (DST) Utilities Specification

    SciTech Connect

    SUSIENE, W.T.

    2000-04-27

    This specification establishes the performance requirements and provides the references to the requisite codes and standards to he applied during the design of the Double-Shell Tank (DST) Utilities Subsystems that support the first phase of waste feed delivery (WFD). The DST Utilities Subsystems provide electrical power, raw/potable water, and service/instrument air to the equipment and structures used to transfer low-activity waste (LAW) and high-level waste (HLW) to designated DST staging tanks. The DST Utilities Subsystems also support the equipment and structures used to deliver blended LAW and HLW feed from these staging tanks to the River Protection Project (RPP) Privatization Contractor facility where the waste will be immobilized. This specification is intended to be the basis for new projects/installations. This specification is not intended to retroactively affect previously established project design criteria without specific direction by the program.

  2. Double Shell Tank (DST) Transfer Valving Specification

    SciTech Connect

    GRAVES, C.E.

    2001-01-17

    This specification establishes the performance requirements and provides references to the requisite codes and standards to be applied during design of the Double-Shell Tank (DST) Transfer Valving Subsystem that supports the first phase of Waste Feed Delivery.

  3. UPC Language Specifications V1.2

    SciTech Connect

    UPC Consortium

    2005-05-31

    UPC is an explicitly parallel extension to the ISO C 99Standard. UPC follows the partitioned global address space programming model. This document is the formal specification for the UPC language syntax and semantics.

  4. Female-specific DNA sequences in geese.

    PubMed

    Huang, M C; Lin, W C; Horng, Y M; Rouvier, R; Huang, C W

    2003-07-01

    1. The OPAE random primers (Operon Technologies, Inc., CA) were used for random amplified polymorphic DNA (RAPD) fingerprinting in Chinese, White Roman and Landaise geese. One of these primers, OPAE-06, produced a 938-bp sex-specific fragment in all females and in no males of Chinese geese only. 2. A novel female-specific DNA sequence in Chinese goose was cloned and sequenced. Two primers, CGSex-F and CGSex-R, were designed in order to amplify a 912-bp sex-specific polymerase chain reaction (PCR) fragment on genomic DNA from female geese. 3. It was shown that a simple and effective PCR-based sexing technique could be used in the three goose breeds studied. 4. Nucleotide sequencing of the sex-specific fragments in White Roman and Landaise geese was performed and sequence differences were observed among these three breeds.

  5. Process Specification for Eddy Current Inspection

    NASA Technical Reports Server (NTRS)

    Koshti, Ajay

    2011-01-01

    This process specification establishes the minimum requirements for eddy current inspection of flat surfaces, fastener holes, threaded fasteners and seamless and welded tubular products made from nonmagnetic alloys such as aluminum and stainless steel.

  6. The NOPAL Language Specification and User Manual.

    DTIC Science & Technology

    1976-08-01

    to validate UUT (Unit Under Test) design test point availability, and packaging. The system is referred to as NOPAL , an acronym for Non-procedural...Operational Performance Analysis Language. Non-proceduralness is the essential feature of the NOPAL language; in that test modules are specified...Specification, and ATE Specification. For each NOPAL statement, its EBNF definition, syntax diagram and examples are provided. (Author)

  7. Specifications and Standards for the Electric Warship

    DTIC Science & Technology

    2013-04-01

    commercial processes when applicable to naval ships. The Naval Combatant Design Specification ( NCDS ) describe requirements at the total ship and the ship...system level for non-nuclear naval surface warships. The NCDS relies upon the military handbooks, specifications and standards in addition to...criteria can either be incorporated in MIL- STD-461F or contained in another document such as NCDS . MIL-E-2036D(SH) Notice 2, Enclosures for Electric

  8. Specific Impulse and Mass Flow Rate Error

    NASA Technical Reports Server (NTRS)

    Gregory, Don A.

    2005-01-01

    Specific impulse is defined in words in many ways. Very early in any text on rocket propulsion a phrase similar to .specific impulse is the thrust force per unit propellant weight flow per second. will be found.(2) It is only after seeing the mathematics written down does the definition mean something physically to scientists and engineers responsible for either measuring it or using someone.s value for it.

  9. Simple Benchmark Specifications for Space Radiation Protection

    NASA Technical Reports Server (NTRS)

    Singleterry, Robert C. Jr.; Aghara, Sukesh K.

    2013-01-01

    This report defines space radiation benchmark specifications. This specification starts with simple, monoenergetic, mono-directional particles on slabs and progresses to human models in spacecraft. This report specifies the models and sources needed to what the team performing the benchmark needs to produce in a report. Also included are brief descriptions of how OLTARIS, the NASA Langley website for space radiation analysis, performs its analysis.

  10. Issues in Interaction Language Specification and Representation.

    DTIC Science & Technology

    1983-11-01

    A16~ REPRESENTATION(J) VIRGINIA POLYTECHNIC INST AND STATE UNIV BLACKSBURG COMPUTER S. D N JOHNSON ET AL. NOV 83 UNCLASSIFIED CSIE-83-15 NBOB14 81 K...8217, ___ 4 ~ISSUES IN INTERACTION LANGUAGE SPECIFICATION AND REPRESENTATION Deborah H. Johnson H. Rex Hartson .4 This document has been approved...ISSUES IN INTERACTION LANGUAGE SPECIFICATION AND REPRESENTATION Deborah H. Johnson H. Rex Hartson TECHNICAL REPORT Prepared for Engineering Psychology

  11. Reflections on the specificity of synaptic connections.

    PubMed

    White, Edward L

    2007-10-01

    The principal focus of this treatise is the specificity of synaptic connectivity in the mammalian central nervous system. The occurrence of stereotypical patterns of connection at the macro level (e.g., the general consistency with which axonal pathways impinge on and originate within specific cortical areas and layers) implies that the cerebral cortex is a highly ordered structure. Order is seen also at the more micro level of synaptic connectivity, for instance, in the contrasting synaptic patterns of spiny vs. non-spiny neurons. Quantitative electron microscopic studies of synapses between identified neurons and correlative anatomical/electrophysiological investigations indicate that the high degree of order characterizing many aspects of cortical organization is mirrored by an equally ordered arrangement of synaptic connections between specific types of neurons. The recognition of recurring synaptic patterns has generated increased support for the notion of synaptic specificity as opposed to randomness, and we have begun now to understand the role of specificity in cortical function. At the core of cortical processing lie myriad possibilities for computation provided by the wealth of synaptic connections involving each neuron. Specificity, by limiting possibilities for connection, imposes an order on synaptic interactions even as processes of dynamic selection or synaptic remodeling ensure the constant formation and dissolution of cortical circuits. Collectively, these operations make maximal use of the richness of cortical synaptic connections to produce a highly flexible system, irrespective of the degree of hard-wiring, mutability, randomness or specificity that obtains for cortical wiring at any particular time. A brief, historical account of developments leading to our current understanding of cortical synaptic organization will precede the presentation of evidence for synaptic specificity.

  12. Language translation, doman specific languages and ANTLR

    NASA Technical Reports Server (NTRS)

    Craymer, Loring; Parr, Terence

    2002-01-01

    We will discuss the features of ANTLR that make it an attractive tool for rapid developement of domain specific language translators and present some practical examples of its use: extraction of information from the Cassini Command Language specification, the processing of structured binary data, and IVL--an English-like language for generating VRML scene graph, which is used in configuring the jGuru.com server.

  13. FTP Extensions for Variable Protocol Specification

    NASA Technical Reports Server (NTRS)

    Allman, Mark; Ostermann, Shawn

    2000-01-01

    The specification for the File Transfer Protocol (FTP) assumes that the underlying network protocols use a 32-bit network address and a 16-bit transport address (specifically IP version 4 and TCP). With the deployment of version 6 of the Internet Protocol, network addresses will no longer be 32-bits. This paper species extensions to FTP that will allow the protocol to work over a variety of network and transport protocols.

  14. Measuring Specific Heats at High Temperatures

    NASA Technical Reports Server (NTRS)

    Vandersande, Jan W.; Zoltan, Andrew; Wood, Charles

    1987-01-01

    Flash apparatus for measuring thermal diffusivities at temperatures from 300 to 1,000 degrees C modified; measures specific heats of samples to accuracy of 4 to 5 percent. Specific heat and thermal diffusivity of sample measured. Xenon flash emits pulse of radiation, absorbed by sputtered graphite coating on sample. Sample temperature measured with thermocouple, and temperature rise due to pulse measured by InSb detector.

  15. 77 FR 27490 - Plant-Specific Adoption, Revision 4 of the Improved Standard Technical Specifications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-10

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY...: Nuclear Regulatory Commission. ACTION: Notice of Availability. SUMMARY: The U.S. Nuclear Regulatory... Specifications, Combustion Engineering Plants,'' NUREG-1433, ``Standard Technical Specifications,...

  16. Germ cell specification and regeneration in planarians.

    PubMed

    Newmark, P A; Wang, Y; Chong, T

    2008-01-01

    In metazoans, two apparently distinct mechanisms specify germ cell fate: Determinate specification (observed in animals including Drosophila, Caenorhabditis elegans, zebra fish, and Xenopus) uses cytoplasmic factors localized to specific regions of the egg, whereas epigenetic specification (observed in many basal metazoans, urodeles, and mammals) involves inductive interactions between cells. Much of our understanding of germ cell specification has emerged from studies of model organisms displaying determinate specification. In contrast, our understanding of epigenetic/inductive specification is less advanced and would benefit from studies of additional organisms. Freshwater planarians--widely known for their remarkable powers of regeneration--are well suited for studying the mechanisms by which germ cells can be induced. Classic experiments showed that planarians can regenerate germ cells from body fragments entirely lacking reproductive structures, suggesting that planarian germ cells could be specified by inductive signals. Furthermore, the availability of the genome sequence of the planarian Schmidtea mediterranea, coupled with the animal's susceptibility to systemic RNA interference (RNAi), facilitates functional genomic analyses of germ cell development and regeneration. Here, we describe recent progress in studies of planarian germ cells and frame some of the critical unresolved questions for future work.

  17. Autobiographical memory specificity in dissociative identity disorder.

    PubMed

    Huntjens, Rafaële J C; Wessel, Ineke; Hermans, Dirk; van Minnen, Agnes

    2014-05-01

    A lack of adequate access to autobiographical knowledge has been related to psychopathology. More specifically, patients suffering from depression or a history of trauma have been found to be characterized by overgeneral memory, in other words, they show a relative difficulty in retrieving a specific event from memory located in time and place. Previous studies of overgeneral memory have not included patients with dissociative disorders. These patients are interesting to consider, as they are hypothesized to have the ability to selectively compartmentalize information linked to negative emotions. This study examined avoidance and overgeneral memory in patients with dissociative identity disorder (DID; n = 12). The patients completed the autobiographical memory test (AMT). Their performance was compared with control groups of posttraumatic stress disorder (PTSD) patients (n = 26), healthy controls (n = 29), and DID simulators (n = 26). Specifically, we compared the performance of separate identity states in DID hypothesized to diverge in the use of avoidance as a coping strategy to deal with negative affect. No significant differences in memory specificity were found between the separate identities in DID. Irrespective of identity state, DID patients were characterized by a lack of memory specificity, which was similar to the lack of memory specificity found in PTSD patients. The converging results for DID and PTSD patients add empirical evidence for the role of overgeneral memory involved in the maintenance of posttraumatic psychopathology.

  18. Specific and non-specific immunity of piglets from sows fed diets containing specific fatty acids in field conditions.

    PubMed

    Benzoni, G; Foresti, F; Archetti, I L; Coceva, G; Guyonvarch, A; Alborali, L

    2013-10-01

    The transfer of passive immunity from sows to piglets is important and it is the first immune protection of the new born piglet. Improving sows immunity by adding immuno-stimulating product in sows diet can positively affect colostrum composition and transfer of immune molecules to piglets. The aim of the current study is to evaluate the benefit of a different solution, made of specific fatty acids from marine origin that have been used in human medicine for decades, for sows and piglets. Two trials were conducted in commercial farm, involving 240 sows at different periods of the year. Sows were divided in a control group, without supplementation, and a test group, supplemented with the feed additive from the 90th day of gestation to weaning. Sows body condition, piglets viability and growth were recorded. Milk immunoglobulin content was measured, as well as Aujeszky antibodies in sows and piglets blood as marker of specific immunity, and blood bactericidal activity, complement activity and lysozyme as markers of non specific immunity. No effect of the product was observed on piglets zootechnical criteria and specific immunity parameters but significant improvement of piglet non specific immunity, was observed. No difference was observed neither in the piglets blood PRRSV and PCV2 antibodies and viruses nor in Aujeszky antibodies. Blood complement activity seems to be an accurate indicator of immuno-stimulating additive efficiency. Giving alkyl-glycerol fatty acids to sows in late gestation and lactation can improve the passive immunity transfer to piglets.

  19. Combination of specific allergen and probiotics induces specific regulatory B cells and enhances specific immunotherapy effect on allergic rhinitis

    PubMed Central

    Yang, Gui; Luo, Xiang-Qian; Miao, Bei-Ping; Geng, Xiao-Rui; Liu, Zhi-Qiang; Liu, Jun; Wen, Zhong; Wang, Shuai; Zhang, Huan-Ping; Li, Jing; Liu, Zhi-Gang; Li, Hua-Bin; Yang, Ping-Chang

    2016-01-01

    The therapeutic efficacy of allergen specific immunotherapy (SIT) on allergic diseases is to be improved. Probiotics can regulate immune response. This study aims to promote the effect of SIT on allergic rhinitis (AR) by co-administration with Clostridium butyricum (Cb). In this study, patients with AR sensitized to mite allergens were enrolled to this study, and treated with SIT or/and Cb. The therapeutic efficacy was evaluated by the total nasal symptom scores (NSS), medication scores, serum specific IgE levels and T helper (Th)2 cytokine levels. The improvement of immune regulation in the AR patients was assessed by immunologic approaches. The results showed that treating AR patients with SIT alone markedly reduced NSS and medication scores; but did not alter the serum specific IgE, Th2 cytokines and skin prick test (SPT) index. The clinical symptoms on AR in SIT group relapsed one month after stopping SIT. Co-administration of Cb significantly enhanced the efficacy of SIT on AR as shown by suppression of NSS, medication scores, serum specific IgE, Th2 cytokines and SPT index; the regulatory B cell frequency was also markedly increased. Such an effect on AR was maintained throughout the observation period even after stopping the treatment. Butyrate blocked the activation of histone deacetylase-1, the downstream activities of epsilon chain promoter activation, and the IgE production in the antigen specific B cells. On the other hand, butyrate induced the IL-10 expression in B cells with a premise of the B cell receptor activation by specific antigens. In conclusion, administration with Cb can markedly enhance the efficacy of SIT on AR. PMID:27486985

  20. Face recognition: a model specific ability.

    PubMed

    Wilmer, Jeremy B; Germine, Laura T; Nakayama, Ken

    2014-01-01

    In our everyday lives, we view it as a matter of course that different people are good at different things. It can be surprising, in this context, to learn that most of what is known about cognitive ability variation across individuals concerns the broadest of all cognitive abilities; an ability referred to as general intelligence, general mental ability, or just g. In contrast, our knowledge of specific abilities, those that correlate little with g, is severely constrained. Here, we draw upon our experience investigating an exceptionally specific ability, face recognition, to make the case that many specific abilities could easily have been missed. In making this case, we derive key insights from earlier false starts in the measurement of face recognition's variation across individuals, and we highlight the convergence of factors that enabled the recent discovery that this variation is specific. We propose that the case of face recognition ability illustrates a set of tools and perspectives that could accelerate fruitful work on specific cognitive abilities. By revealing relatively independent dimensions of human ability, such work would enhance our capacity to understand the uniqueness of individual minds.

  1. Chromosome-specific DNA Repeat Probes

    SciTech Connect

    Baumgartner, Adolf; Weier, Jingly Fung; Weier, Heinz-Ulrich G.

    2006-03-16

    In research as well as in clinical applications, fluorescence in situ hybridization (FISH) has gained increasing popularity as a highly sensitive technique to study cytogenetic changes. Today, hundreds of commercially available DNA probes serve the basic needs of the biomedical research community. Widespread applications, however, are often limited by the lack of appropriately labeled, specific nucleic acid probes. We describe two approaches for an expeditious preparation of chromosome-specific DNAs and the subsequent probe labeling with reporter molecules of choice. The described techniques allow the preparation of highly specific DNA repeat probes suitable for enumeration of chromosomes in interphase cell nuclei or tissue sections. In addition, there is no need for chromosome enrichment by flow cytometry and sorting or molecular cloning. Our PCR-based method uses either bacterial artificial chromosomes or human genomic DNA as templates with {alpha}-satellite-specific primers. Here we demonstrate the production of fluorochrome-labeled DNA repeat probes specific for human chromosomes 17 and 18 in just a few days without the need for highly specialized equipment and without the limitation to only a few fluorochrome labels.

  2. Face recognition: a model specific ability

    PubMed Central

    Wilmer, Jeremy B.; Germine, Laura T.; Nakayama, Ken

    2014-01-01

    In our everyday lives, we view it as a matter of course that different people are good at different things. It can be surprising, in this context, to learn that most of what is known about cognitive ability variation across individuals concerns the broadest of all cognitive abilities; an ability referred to as general intelligence, general mental ability, or just g. In contrast, our knowledge of specific abilities, those that correlate little with g, is severely constrained. Here, we draw upon our experience investigating an exceptionally specific ability, face recognition, to make the case that many specific abilities could easily have been missed. In making this case, we derive key insights from earlier false starts in the measurement of face recognition’s variation across individuals, and we highlight the convergence of factors that enabled the recent discovery that this variation is specific. We propose that the case of face recognition ability illustrates a set of tools and perspectives that could accelerate fruitful work on specific cognitive abilities. By revealing relatively independent dimensions of human ability, such work would enhance our capacity to understand the uniqueness of individual minds. PMID:25346673

  3. Predicting tissue specific transcription factor binding sites

    PubMed Central

    2013-01-01

    Background Studies of gene regulation often utilize genome-wide predictions of transcription factor (TF) binding sites. Most existing prediction methods are based on sequence information alone, ignoring biological contexts such as developmental stages and tissue types. Experimental methods to study in vivo binding, including ChIP-chip and ChIP-seq, can only study one transcription factor in a single cell type and under a specific condition in each experiment, and therefore cannot scale to determine the full set of regulatory interactions in mammalian transcriptional regulatory networks. Results We developed a new computational approach, PIPES, for predicting tissue-specific TF binding. PIPES integrates in vitro protein binding microarrays (PBMs), sequence conservation and tissue-specific epigenetic (DNase I hypersensitivity) information. We demonstrate that PIPES improves over existing methods on distinguishing between in vivo bound and unbound sequences using ChIP-seq data for 11 mouse TFs. In addition, our predictions are in good agreement with current knowledge of tissue-specific TF regulation. Conclusions We provide a systematic map of computationally predicted tissue-specific binding targets for 284 mouse TFs across 55 tissue/cell types. Such comprehensive resource is useful for researchers studying gene regulation. PMID:24238150

  4. Reduced goal specificity is associated with reduced memory specificity in depressed adults.

    PubMed

    Belcher, Jessica; Kangas, Maria

    2014-01-01

    Models of autobiographical memory suggest a close association between memories, future imagination and setting specific personal goals. However this association has yet to be tested with depressed individuals. The aim of this study was to examine whether the specificity of remembering past and imagining future personal events is associated with the specificity of approach and avoidance goals in depressed individuals. Two samples comprising adults who met criteria for major depressive disorder (MDD; N=30) and adults who had no prior history or current depression (N=30) completed autobiographical memory and future event tests, and a personal goal task. In the depressed sample, the specificity with which participants remembered the past was significantly associated with the specificity with which they generated future goals. The depressed sample also elicited fewer specific approach and avoidance goals compared to the non-depressed sample. These findings suggest that an overgeneral memory deficit extends to impairments in goal specificity.

  5. Polysaccharides in colon-specific drug delivery.

    PubMed

    Sinha, V R; Kumria, R

    2001-08-14

    Natural polysaccharides are now extensively used for the development of solid dosage forms for delivery of drug to the colon. The rationale for the development of a polysaccharide based delivery system for colon is the presence of large amounts of polysaccharidases in the human colon as the colon is inhabited by a large number and variety of bacteria which secrete many enzymes e.g. beta-D-glucosidase, beta-D-galactosidase, amylase, pectinase, xylanase, beta-D-xylosidase, dextranase, etc. Various major approaches utilizing polysaccharides for colon-specific delivery are fermentable coating of the drug core, embedding of the drug in biodegradable matrix, formulation of drug-saccharide conjugate (prodrugs). A large number of polysaccharides have already been studied for their potential as colon-specific drug carrier systems, such as chitosan, pectin, chondroitin sulphate, cyclodextrin, dextrans, guar gum, inulin, amylose and locust bean gum. Recent efforts and approaches exploiting these polysaccharides in colon-specific drug delivery are discussed.

  6. Cell specific, variable density, polymer microspheres

    NASA Technical Reports Server (NTRS)

    Yen, Shiao-Ping S. (Inventor); Rembaum, Alan (Inventor); Molday, Robert S. (Inventor)

    1978-01-01

    Biocompatible polymeric microspheres having an average diameter below about 3 microns and having a density at least 15% greater or lesser than organic cells and having covalent binding sites are provided in accordance with this invention. The microspheres are obtained by copolymerizing a hydroxy or amine substituted acrylic monomer such as hydroxyethylmethacrylate with a light or dense comonomer such as a fluoromonomer. A lectin or antibody is bound to the hydroxy or amine site of the bead to provide cell specificity. When added to a cell suspension the marked bead will specifically label the cell membrane by binding to specific receptor sites thereon. The labelled membrane can then be separated by density gradient centrifugation.

  7. Functional specificity of rat vibrissal primary afferents.

    PubMed

    Lucianna, Facundo A; Farfán, Fernando D; Pizá, Gabriel A; Albarracín, Ana L; Felice, Carmelo J

    2016-06-01

    In this study, we propose to analyze the peripheral vibrissal system specificity through its neuronal responses. Receiver operating characteristics (ROC) curve analyses were used, which required the implementation of a binary classifier (artificial neural network) trained to identify the applied stimulus. The training phase consisted of the observation of a predetermined amount of vibrissal sweeps on two surfaces of different texture and similar roughness. Our results suggest that the specificity of the peripheral vibrissal system easily permits the discrimination between perceived stimuli, quantified through neuronal responses, and that it can be evaluated through an ROC curve analysis. We found that such specificity makes a linear binary classifier capable of detecting differences between stimuli with five sweeps at most.

  8. The Specific Analysis of Structural Equation Models.

    PubMed

    McDonald, Roderick P

    2004-10-01

    Conventional structural equation modeling fits a covariance structure implied by the equations of the model. This treatment of the model often gives misleading results because overall goodness of fit tests do not focus on the specific constraints implied by the model. An alternative treatment arising from Pearl's directed acyclic graph theory checks identifiability and lists and tests the implied constraints. This approach is complete for Markov models, but has remained incomplete for models with correlated disturbances. Some new algebraic results overcome the limitations of DAG theory and give a specific form of structural equation analysis that checks identifiability, tests the implied constraints, equation by equation, and gives consistent estimators of the parameters in closed form from the equations. At present the method is limited to recursive models subject to exclusion conditions. With further work, specific structural equation modeling may yield a complete alternative to the present, rather unsatisfactory, global covariance structure analysis.

  9. Examining site-specific GPCR phosphorylation.

    PubMed

    Butcher, Adrian J; Tobin, Andrew B; Kong, Kok Choi

    2011-01-01

    Phosphorylation of G protein-coupled receptors (GPCRs) is one of the most prominent post-translation modifications mediated by agonist stimulation. This process has been shown to result not only in receptor desensitisation but also, via the recruitment of arrestin adaptor proteins, to promote receptor coupling to numerous signalling pathways. Furthermore, there is now a growing body of evidence suggesting that GPCRs may employ phosphorylation as a mechanism to regulate their cell-type-specific signalling, hence generating tissue-specific functions. These advances have resulted partly from improved methods used in the determination of phospho-acceptor sites on GPCRs and improved analysis of the consequences of phosphorylation. This chapter aims to describe the methods used in our laboratory for the investigation of site-specific phosphorylation of the M₃-muscarinic receptor. These methods could easily be applied in the study of other receptors.

  10. Specificity and stereospecificity of α-chymotrypsin

    PubMed Central

    Ingles, D. W.; Knowles, J. R.

    1967-01-01

    1. The optically pure p-nitrophenyl esters of the d and l enantiomers of N-acetyl-tryptophan, N-acetylphenylalanine and N-acetyl-leucine, and the p-nitrophenyl ester of N-acetylglycine, have been prepared. 2. These materials are all substrates of α-chymotrypsin, and the rates of deacylation of the corresponding acyl-α-chymotrypsins have been determined. 3. As the size of the amino acid side chain increases, the l series deacylate progressively faster than the N-acetylglycyl-enzyme, and the d series progressively more slowly. 4. The results are interpreted in terms of a three-locus model of the enzyme's active site, which accounts for the interrelationship between substrate specificity and stereospecificity observed. 5. The concepts of negative specificity and of specificity saturation are introduced. PMID:6048779

  11. AWS breaks new ground with soldering specification.

    SciTech Connect

    Vianco, Paul Thomas

    2008-08-01

    Joining technologies continue to advance with new materials, process innovations, and inspection techniques. An increasing number of high-valued, high-reliability applications -- from boilers and ship hulls to rocket motors and medical devices -- have required the development of industry standards and specifications in order to ensure that the best design and manufacturing practices are being used to produce safe, durable products and assemblies. Standards writing has always had an important role at the American Welding Society (AWS). The AWS standards and specifications cover such topics as filler materials, joining processes, inspection techniques, and qualification methods that are used in welding and brazing technologies. These AWS standards and specifications, all of which are approved by the American National Standards Institute (ANSI), have also provided the basis for many similar documents used in Europe and in Pacific Rim countries.

  12. Specific heat of multifractal energy spectra

    NASA Astrophysics Data System (ADS)

    da Silva, L. R.; Vallejos, R. O.; Tsallis, C.; Mendes, R. S.; Roux, S.

    2001-07-01

    Motivated by the self-similar character of energy spectra demonstrated for quasicrystals, we investigate the case of multifractal energy spectra, and compute the specific heat associated with simple archetypal forms of multifractal sets as generated by iterated maps. We considered the logistic map and the circle map at their threshold to chaos. Both examples show nontrivial structures associated with the scaling properties of their respective chaotic attractors. The specific heat displays generically log-periodic oscillations around a value that characterizes a single exponent, the ``fractal dimension,'' of the distribution of energy levels close to the minimum value set to 0. It is shown that when the fractal dimension and the frequency of log oscillations of the density of states are large, the amplitude of the resulting log oscillation in the specific heat becomes much smaller than the log-periodic oscillation measured on the density of states.

  13. Organelle-Specific Initiation of Autophagy.

    PubMed

    Sica, Valentina; Galluzzi, Lorenzo; Bravo-San Pedro, José Manuel; Izzo, Valentina; Maiuri, Maria Chiara; Kroemer, Guido

    2015-08-20

    Autophagy constitutes a prominent mechanism through which eukaryotic cells preserve homeostasis in baseline conditions and in response to perturbations of the intracellular or extracellular microenvironment. Autophagic responses can be relatively non-selective or target a specific subcellular compartment. At least in part, this depends on the balance between the availability of autophagic substrates ("offer") and the cellular need of autophagic products or functions for adaptation ("demand"). Irrespective of cargo specificity, adaptive autophagy relies on a panel of sensors that detect potentially dangerous cues and convert them into signals that are ultimately relayed to the autophagic machinery. Here, we summarize the molecular systems through which specific subcellular compartments-including the nucleus, mitochondria, plasma membrane, reticular apparatus, and cytosol-convert homeostatic perturbations into an increased offer of autophagic substrates or an accrued cellular demand for autophagic products or functions.

  14. Specificity in Legume-Rhizobia Symbioses.

    PubMed

    Andrews, Mitchell; Andrews, Morag E

    2017-03-26

    Most species in the Leguminosae (legume family) can fix atmospheric nitrogen (N₂) via symbiotic bacteria (rhizobia) in root nodules. Here, the literature on legume-rhizobia symbioses in field soils was reviewed and genotypically characterised rhizobia related to the taxonomy of the legumes from which they were isolated. The Leguminosae was divided into three sub-families, the Caesalpinioideae, Mimosoideae and Papilionoideae. Bradyrhizobium spp. were the exclusive rhizobial symbionts of species in the Caesalpinioideae, but data are limited. Generally, a range of rhizobia genera nodulated legume species across the two Mimosoideae tribes Ingeae and Mimoseae, but Mimosa spp. show specificity towards Burkholderia in central and southern Brazil, Rhizobium/Ensifer in central Mexico and Cupriavidus in southern Uruguay. These specific symbioses are likely to be at least in part related to the relative occurrence of the potential symbionts in soils of the different regions. Generally, Papilionoideae species were promiscuous in relation to rhizobial symbionts, but specificity for rhizobial genus appears to hold at the tribe level for the Fabeae (Rhizobium), the genus level for Cytisus (Bradyrhizobium), Lupinus (Bradyrhizobium) and the New Zealand native Sophora spp. (Mesorhizobium) and species level for Cicer arietinum (Mesorhizobium), Listia bainesii (Methylobacterium) and Listia angolensis (Microvirga). Specificity for rhizobial species/symbiovar appears to hold for Galega officinalis (Neorhizobium galegeae sv. officinalis), Galega orientalis (Neorhizobium galegeae sv. orientalis), Hedysarum coronarium (Rhizobium sullae), Medicago laciniata (Ensifer meliloti sv. medicaginis), Medicago rigiduloides (Ensifer meliloti sv. rigiduloides) and Trifolium ambiguum (Rhizobium leguminosarum sv. trifolii). Lateral gene transfer of specific symbiosis genes within rhizobial genera is an important mechanism allowing legumes to form symbioses with rhizobia adapted to particular soils

  15. Nutrient-Specific Foraging in Invertebrate Predators

    NASA Astrophysics Data System (ADS)

    Mayntz, David; Raubenheimer, David; Salomon, Mor; Toft, Søren; Simpson, Stephen J.

    2005-01-01

    Many herbivores and omnivores adjust their food selection behavior to regulate the intake of multiple nutrients. Carnivores, however, are generally assumed to optimize the rate of prey capture rather than select prey according to nutrient composition. We showed experimentally that invertebrate predators can forage selectively for protein and lipids to redress specific nutritional imbalances. This selection can take place at different stages of prey handling: The predator may select among foods of different nutritional composition, eat more of a prey if it is rich in nutrients that the predator is deficient in, or extract specific nutrients from a single prey item.

  16. Software engineering with application-specific languages

    NASA Technical Reports Server (NTRS)

    Campbell, David J.; Barker, Linda; Mitchell, Deborah; Pollack, Robert H.

    1993-01-01

    Application-Specific Languages (ASL's) are small, special-purpose languages that are targeted to solve a specific class of problems. Using ASL's on software development projects can provide considerable cost savings, reduce risk, and enhance quality and reliability. ASL's provide a platform for reuse within a project or across many projects and enable less-experienced programmers to tap into the expertise of application-area experts. ASL's have been used on several software development projects for the Space Shuttle Program. On these projects, the use of ASL's resulted in considerable cost savings over conventional development techniques. Two of these projects are described.

  17. Biofilm-specific antibiotic tolerance and resistance.

    PubMed

    Olsen, I

    2015-05-01

    Biofilms are heterogeneous structures composed of bacterial cells surrounded by a matrix and attached to solid surfaces. The bacteria here are 100 to 1,000 times more tolerant to antimicrobials than corresponding planktonic cells. Biofilms can be difficult to eradicate when they cause biofilm-related diseases, e.g., implant infections, cystic fibrosis, urinary tract infections, and periodontal diseases. A number of phenotypic features of the biofilm can be involved in biofilm-specific tolerance and resistance. Little is known about the molecular mechanisms involved. The current review deals with both phenotypic and molecular mechanisms of biofilm-specific antibiotic tolerance and resistance.

  18. Specifications from a biotechnology industry perspective.

    PubMed

    Garnick, R L

    1997-01-01

    The emergence of new analytical technology and the production of pharmaceuticals for a global market in a cost-effective manner necessitate the establishment of worldwide specifications that are appropriate for the product and the manufacturing process. This requires a thorough knowledge of the protein and control of the systems that produce it as well as an understanding of the accuracy and precision of the assays used for testing. Harmonization of specifications among the worldwide regulatory authorities is critical for the future development of new pharmaceuticals. A continuing dialogue between industry and regulators to achieve this goal needs to be encouraged and supported.

  19. Eye specification in Drosophila: perspectives and implications.

    PubMed

    Kumar, J P; Moses, K

    2001-12-01

    The discovery that Drosophila eyeless is homologous to vertebrate Pax6 produced enormous interest in eye specification and a reappraisal of eye evolution. While the transcription factor Eyeless/Pax6 is necessary and in some circumstances sufficient to induce eye development the simple story of eye specification has become more epic than haiku. At least seven other nuclear proteins act with Eyeless/Pax6 to induce the eye and, furthermore, extrinsic developmental signals are required. Some striking similarities between later events of retinal patterning in vertebrates and insects have led to a deeper debate on the evolutionary path to these apparently quite different organs.

  20. [Development of domain specific search engines].

    PubMed

    Takai, T; Tokunaga, M; Maeda, K; Kaminuma, T

    2000-01-01

    As cyber space exploding in a pace that nobody has ever imagined, it becomes very important to search cyber space efficiently and effectively. One solution to this problem is search engines. Already a lot of commercial search engines have been put on the market. However these search engines respond with such cumbersome results that domain specific experts can not tolerate. Using a dedicate hardware and a commercial software called OpenText, we have tried to develop several domain specific search engines. These engines are for our institute's Web contents, drugs, chemical safety, endocrine disruptors, and emergent response for chemical hazard. These engines have been on our Web site for testing.

  1. DAPI: a DNA-specific fluorescent probe.

    PubMed

    Kapuscinski, J

    1995-09-01

    DAPI (4',6-diamidino-2-phenylindole) is a DNA-specific probe which forms a fluorescent complex by attaching in the minor grove of A-T rich sequences of DNA. It also forms nonfluorescent intercalative complexes with double-stranded nucleic acids. The physicochemical properties of the dye and its complexes with nucleic acids and history of the development of this dye as a biological stain are described. The application of DAPI as a DNA-specific probe for flow cytometry, chromosome staining, DNA visualization and quantitation in histochemistry and biochemistry is reviewed. The mechanisms of DAPI-nucleic acid complex formation including minor groove binding, intercalation and condensation are discussed.

  2. Interactive specification acquisition via scenarios: A proposal

    NASA Technical Reports Server (NTRS)

    Hall, Robert J.

    1992-01-01

    Some reactive systems are most naturally specified by giving large collections of behavior scenarios. These collections not only specify the behavior of the system, but also provide good test suites for validating the implemented system. Due to the complexity of the systems and the number of scenarios, however, it appears that automated assistance is necessary to make this software development process workable. Interactive Specification Acquisition Tool (ISAT) is a proposed interactive system for supporting the acquisition and maintenance of a formal system specification from scenarios, as well as automatic synthesis of control code and automated test generation. This paper discusses the background, motivation, proposed functions, and implementation status of ISAT.

  3. Site-Specific Infrared Probes of Proteins

    PubMed Central

    Ma, Jianqiang; Pazos, Ileana M.; Zhang, Wenkai; Culik, Robert M.; Gai, Feng

    2015-01-01

    Infrared spectroscopy has played an instrumental role in studying a wide variety of biological questions. However, in many cases it is impossible or difficult to rely on the intrinsic vibrational modes of biological molecules of interest, such as proteins, to reveal structural and/or environmental information in a site-specific manner. To overcome this limitation, many recent efforts have been dedicated to the development and application of various extrinsic vibrational probes that can be incorporated into biological molecules and used to site-specifically interrogate their structural and/or environmental properties. In this Review, we highlight some recent advancements of this rapidly growing research area. PMID:25580624

  4. DOE site-specific threat assessment

    SciTech Connect

    West, D.J.; Al-Ayat, R.A.; Judd, B.R.

    1985-07-12

    A facility manager faced with the challenges of protecting a nuclear facility against potential threats must consider the likelihood and consequences of such threats, know the capabilities of the facility safeguards and security systems, and make informed decisions about the cost-effectivness of safeguards and security upgrades. To help meet these challenges, the San Francisco Operations Office of the Department of Energy, in conjunction with the Lawrence Livermore Laboratory, has developed a site-specific threat assessment approach and a quantitative model to improve the quality and consistency of site-specific threat assessment and resultant security upgrade decisions at sensitive Department of Energy facilities. 5 figs.

  5. Issues in Interaction Language Specification and Representation.

    DTIC Science & Technology

    1983-11-01

    JOHNSON ET AL. NOV 83 UNCLASSIFIED CSIE-83-15 N@014-8 1K -143 F/G 5/8 N mEEEomhEEEmhiI EEEEEEEEmhEEEE mEEEEEEEmhEEEE EEEEEEEEohEohEmhE~~hEEEEEE 1.8...IN - INTERACTION LANGUAGE SPECIFICATION CAND REPRESENTATION Deborah H. Johnson H. Rex Hartson N nT1C Virginia Polytechnic Institute and State...oISSUES IN INTERACTION LANGUAGE SPECIFICATION N. AND REPRESENTATION Deborah H. Johnson I. H. Rex Hartson - I TECHNICAL REPORT Prepared for Engineering

  6. Engineered waste-package-system design specification

    SciTech Connect

    Not Available

    1983-05-01

    This report documents the waste package performance requirements and geologic and waste form data bases used in developing the conceptual designs for waste packages for salt, tuff, and basalt geologies. The data base reflects the latest geotechnical information on the geologic media of interest. The parameters or characteristics specified primarily cover spent fuel, defense high-level waste, and commercial high-level waste forms. The specification documents the direction taken during the conceptual design activity. A separate design specification will be developed prior to the start of the preliminary design activity.

  7. Specificity and disease in the ubiquitin system.

    PubMed

    Chaugule, Viduth K; Walden, Helen

    2016-02-01

    Post-translational modification (PTM) of proteins by ubiquitination is an essential cellular regulatory process. Such regulation drives the cell cycle and cell division, signalling and secretory pathways, DNA replication and repair processes and protein quality control and degradation pathways. A huge range of ubiquitin signals can be generated depending on the specificity and catalytic activity of the enzymes required for attachment of ubiquitin to a given target. As a consequence of its importance to eukaryotic life, dysfunction in the ubiquitin system leads to many disease states, including cancers and neurodegeneration. This review takes a retrospective look at our progress in understanding the molecular mechanisms that govern the specificity of ubiquitin conjugation.

  8. Non-specific ileojejunitis in Arequipa, Peru.

    PubMed

    Perea, V D; Fernan-Zegarra, L; Cruz, V M; Ballon, R; Picoaga, J L

    1978-09-09

    Non-specific ileojejunitis, characterised by mild to moderate structural changes in the intestinal mucosa and often associated with asymptomatic malabsorption, is known to occur in the tropics and in countries with hot climates. This acquired condition is probably related to environmental factors, and some consider it to be a subclinical form of tropical sprue. Changes in the intestinal mucosa typical of non-specific ileojejunitis were found in 10 indigenous Indians as well as 5 people of Latin stock living in the Southern Peruvian sierra, where tropical sprue has not as yet been demonstrated and which has a temperate climate.

  9. 24 CFR 2003.9 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 5 2014-04-01 2014-04-01 false Specific exemptions. 2003.9 Section 2003.9 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF INSPECTOR GENERAL, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT IMPLEMENTATION OF THE...

  10. 24 CFR 16.15 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Specific exemptions. 16.15 Section 16.15 Housing and Urban Development Office of the Secretary, Department of Housing and Urban... Housing and Urban Development determines it to be necessary and proper, with respect to any system...

  11. 10 CFR 50.12 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., the availability of alternative sources, if any, to meet those needs on a timely basis and delay costs... 10 Energy 1 2012-01-01 2012-01-01 false Specific exemptions. 50.12 Section 50.12 Energy NUCLEAR... activities would foreclose subsequent adoption of alternatives; and (4) The effect of delay in...

  12. The Domain Specificity of Academic Emotional Experiences

    ERIC Educational Resources Information Center

    Goetz, Thomas; Frenzel, Anne C.; Pekrun, Reinhard; Hall, Nathan C.

    2006-01-01

    The authors analyzed the domain specificity of emotions and focused on experiences of enjoyment, anxiety, and boredom in the domains of mathematics, Latin, German, and English. On the basis of assumptions in R. Pekrun's (2000; in press) control-value theory and findings of pilot studies, the authors hypothesized the existence of a largely…

  13. Site-Specific Rules for Risk Assessment.

    ERIC Educational Resources Information Center

    Tucker, William; And Others

    1994-01-01

    This article examines the development of regulatory guidance upon which the technology of risk assessment has matured into a decision-making method of choice. It examines in particular the role of site-specific risk assessment at Superfund sites. (LZ)

  14. Primary Auditory Cortex Regulates Threat Memory Specificity

    ERIC Educational Resources Information Center

    Wigestrand, Mattis B.; Schiff, Hillary C.; Fyhn, Marianne; LeDoux, Joseph E.; Sears, Robert M.

    2017-01-01

    Distinguishing threatening from nonthreatening stimuli is essential for survival and stimulus generalization is a hallmark of anxiety disorders. While auditory threat learning produces long-lasting plasticity in primary auditory cortex (Au1), it is not clear whether such Au1 plasticity regulates memory specificity or generalization. We used…

  15. 31 CFR 536.313 - Specific license.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Specific license. 536.313 Section 536.313 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY NARCOTICS TRAFFICKING SANCTIONS REGULATIONS...

  16. 31 CFR 536.313 - Specific license.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Specific license. 536.313 Section 536.313 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY NARCOTICS TRAFFICKING SANCTIONS REGULATIONS...

  17. 31 CFR 536.313 - Specific license.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Specific license. 536.313 Section 536.313 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY NARCOTICS TRAFFICKING SANCTIONS REGULATIONS...

  18. 31 CFR 536.313 - Specific license.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Specific license. 536.313 Section 536.313 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY NARCOTICS TRAFFICKING SANCTIONS REGULATIONS...

  19. 31 CFR 536.313 - Specific license.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Specific license. 536.313 Section 536.313 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY NARCOTICS TRAFFICKING SANCTIONS REGULATIONS...

  20. Public Address Systems. Specifications - Installation - Operation.

    ERIC Educational Resources Information Center

    Palmer, Fred M.

    Provisions for public address in new construction of campus buildings (specifications, installations, and operation of public address systems), are discussed in non-technical terms. Consideration is given to microphones, amplifiers, loudspeakers and the placement and operation of various different combinations. (FS)

  1. English for Specific Purposes. Information Guide 2.

    ERIC Educational Resources Information Center

    British Council, London (England). English-Teaching Information Centre.

    This bibliography of materials for teachers of English for specific purposes lists textbooks, technical readers, articles, resource books, reports, dictionaries, reference books, bibliographies, word frequency lists, catalogues of teaching aids, games and activities, current research in Britain, documents available in the archives of the English…

  2. Ultrasonic hydrometer. [Specific gravity of electrolyte

    DOEpatents

    Swoboda, C.A.

    1982-03-09

    The disclosed ultrasonic hydrometer determines the specific gravity (density) of the electrolyte of a wet battery, such as a lead-acid battery. The hydrometer utilizes a transducer that when excited emits an ultrasonic impulse that traverses through the electrolyte back and forth between spaced sonic surfaces. The transducer detects the returning impulse, and means measures the time t between the initial and returning impulses. Considering the distance d between the spaced sonic surfaces and the measured time t, the sonic velocity V is calculated with the equation V = 2d/t. The hydrometer also utilizes a thermocouple to measure the electrolyte temperature. A hydrometer database correlates three variable parameters including sonic velocity in and temperature and specific gravity of the electrolyte, for temperature values between 0 and 40/sup 0/C and for specific gravity values between 1.05 and 1.30. Upon knowing two parameters (the calculated sonic velocity and the measured temperature), the third parameter (specific gravity) can be uniquely found in the database. The hydrometer utilizes a microprocessor for data storage and manipulation.

  3. 12 CFR 347.119 - Specific consent.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... control such organization as a result of a foreign investment; or (ii) A bank would be establishing a... processing procedure. (d) Specific consent. Direct or indirect investments in or activities of foreign... foreign country. (1) Applicable law or practice in the foreign country where the foreign organization...

  4. Microscale purification of antigen-specific antibodies.

    PubMed

    Brown, Eric P; Normandin, Erica; Osei-Owusu, Nana Yaw; Mahan, Alison E; Chan, Ying N; Lai, Jennifer I; Vaccari, Monica; Rao, Mangala; Franchini, Genoveffa; Alter, Galit; Ackerman, Margaret E

    2015-10-01

    Glycosylation of the Fc domain is an important driver of antibody effector function. While assessment of antibody glycoform compositions observed across total plasma IgG has identified differences associated with a variety of clinical conditions, in many cases it is the glycosylation state of only antibodies against a specific antigen or set of antigens that may be of interest, for example, in defining the potential effector function of antibodies produced during disease or after vaccination. Historically, glycoprofiling such antigen-specific antibodies in clinical samples has been challenging due to their low prevalence, the high sample requirement for most methods of glycan determination, and the lack of high-throughput purification methods. New methods of glycoprofiling with lower sample requirements and higher throughput have motivated the development of microscale and automatable methods for purification of antigen-specific antibodies from polyclonal sources such as clinical serum samples. In this work, we present a robot-compatible 96-well plate-based method for purification of antigen-specific antibodies, suitable for such population level glycosylation screening. We demonstrate the utility of this method across multiple antibody sources, using both purified plasma IgG and plasma, and across multiple different antigen types, with enrichment factors greater than 1000-fold observed. Using an on-column IdeS protease treatment, we further describe staged release of Fc and Fab domains, allowing for glycoprofiling of each domain.

  5. Diamond Drilling Specification Manual and Course Outline.

    ERIC Educational Resources Information Center

    British Columbia Dept. of Education, Victoria.

    This publication presents the standards required of a person practicing diamond drilling in western Canada and provides an outline for teaching the skills and knowledge. It is divided into two parts. The Diamond Drilling Specification Manual establishes the levels of skill and knowledge required in the four certified levels of diamond drilling.…

  6. System specification for the reusable reentry satellite

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The RRS design shall provide a relatively inexpensive method of access to micro and fractional gravity space environments for an extended period of time, with eventual intact recovery on the surface of the Earth. This specification establishes the performance, design, development, and test requirements for the Reusable Reentry Satellite (RRS) system.

  7. Specificity, Transfer, and the Development of Expertise

    ERIC Educational Resources Information Center

    Brookes, David T.; Ross, Brian H.; Mestre, Jose P.

    2011-01-01

    In this paper we present the results of two experiments designed to understand how physics students' learning of the concept of refraction is influenced by the cognitive phenomenon of "specificity." In both experiments participants learned why light bends as it travels from one optical medium to another with an analogy made to a car…

  8. 76 FR 30551 - Specifications for Packagings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-26

    ... Pipeline and Hazardous Materials Safety Administration 49 CFR Part 178 Specifications for Packagings CFR... on a packaging, a test report must be prepared. The test report must be maintained at each location where the packaging is manufactured and each location where the design qualification tests are...

  9. 31 CFR 586.315 - Specific license.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Specific license. 586.315 Section 586.315 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY FEDERAL REPUBLIC OF YUGOSLAVIA (SERBIA &...

  10. Development of the Specific Adaptation Mobility Cane.

    ERIC Educational Resources Information Center

    Arrington, S.

    1995-01-01

    A travel cane was adapted for use by a 10-year-old boy with cortical blindness, severe mental retardation and cerebral palsy affecting his left arm and leg. The Specific Adaptation Mobility Cane utilizes the affected arm to hold the cane while leaving the other hand free for trailing walls, opening doors, carrying objects, and holding handrails.…

  11. Estimating Genotype- and Environment-Specific Heritabilities

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The advantages of computing genotype- and environment-specific heritabilities are discussed. A statistical approach is used in which logvariances of both genotype by environment interaction and error are modeled as random variables. Resulting estimators of variances are weighted averages of a pool...

  12. Sense and specificity in neuronal calcium signalling☆

    PubMed Central

    Burgoyne, Robert D.; Haynes, Lee P.

    2015-01-01

    Changes in the intracellular free calcium concentration ([Ca2 +]i) in neurons regulate many and varied aspects of neuronal function over time scales from microseconds to days. The mystery is how a single signalling ion can lead to such diverse and specific changes in cell function. This is partly due to aspects of the Ca2 + signal itself, including its magnitude, duration, localisation and persistent or oscillatory nature. The transduction of the Ca2 + signal requires Ca2 + binding to various Ca2 + sensor proteins. The different properties of these sensors are important for differential signal processing and determine the physiological specificity of Ca2 + signalling pathways. A major factor underlying the specific roles of particular Ca2 + sensor proteins is the nature of their interaction with target proteins and how this mediates unique patterns of regulation. We review here recent progress from structural analyses and from functional analyses in model organisms that have begun to reveal the rules that underlie Ca2 + sensor protein specificity for target interaction. We discuss three case studies exemplifying different aspects of Ca2 + sensor/target interaction. This article is part of a special issue titled the 13th European Symposium on Calcium. PMID:25447549

  13. 28 CFR 0.131 - Specific functions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE Bureau of Alcohol, Tobacco, Firearms, and Explosives § 0.131 Specific functions. The Director of the Bureau of Alcohol... explosives materials and devices, train canines as explosives detection canines, and conduct research...

  14. 10 CFR 95.11 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Specific exemptions. 95.11 Section 95.11 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) FACILITY SECURITY CLEARANCE AND SAFEGUARDING OF NATIONAL SECURITY... purpose of the rule; (3) When compliance would result in undue hardship or other costs that...

  15. Analyzing Languages for Specific Purposes Discourse

    ERIC Educational Resources Information Center

    Bowles, Hugo

    2012-01-01

    In the last 20 years, technological advancement and increased multidisciplinarity has expanded the range of data regarded as within the scope of languages for specific purposes (LSP) research and the means by which they can be analyzed. As a result, the analytical work of LSP researchers has developed from a narrow focus on specialist terminology…

  16. Side-Specific Reward Memories in Honeybees

    ERIC Educational Resources Information Center

    Gil, Mariana; Menzel, Randolf; De Marco, Rodrigo J.

    2009-01-01

    We report a hitherto unknown form of side-specific learning in honeybees. We trained bees individually by coupling gustatory and mechanical stimulation of each antenna with either increasing or decreasing volumes of sucrose solution offered to the animal's proboscis along successive learning trials. Next, we examined their proboscis extension…

  17. 50 CFR 648.260 - Specifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Specifications. 648.260 Section 648.260 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE FISHERIES OF THE NORTHEASTERN UNITED STATES Management Measures for the Atlantic...

  18. 50 CFR 648.292 - Tilefish specifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Tilefish specifications. 648.292 Section 648.292 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE FISHERIES OF THE NORTHEASTERN UNITED STATES Management Measures for...

  19. 50 CFR 648.122 - Scup specifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Scup specifications. 648.122 Section 648.122 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE FISHERIES OF THE NORTHEASTERN UNITED STATES Management Measures for...

  20. 50 CFR 648.165 - Framework specifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...-based performance standard, the means by which discard data are collected/obtained, fishery... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Framework specifications. 648.165 Section 648.165 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND...

  1. 50 CFR 648.260 - Specifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Specifications. 648.260 Section 648.260 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE FISHERIES OF THE NORTHEASTERN UNITED STATES Management Measures for the Atlantic...

  2. 16 CFR 1702.12 - Packaging specifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Packaging specifications. 1702.12 Section 1702.12 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION...

  3. 16 CFR 1702.11 - Product specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Product specifications. 1702.11 Section 1702.11 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION...

  4. 16 CFR 1702.12 - Packaging specifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Packaging specifications. 1702.12 Section 1702.12 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION...

  5. 16 CFR 1702.11 - Product specifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Product specifications. 1702.11 Section 1702.11 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION...

  6. 16 CFR 1702.11 - Product specifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Product specifications. 1702.11 Section 1702.11 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION...

  7. 16 CFR 1702.12 - Packaging specifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Packaging specifications. 1702.12 Section 1702.12 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION...

  8. 16 CFR 1702.12 - Packaging specifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Packaging specifications. 1702.12 Section 1702.12 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION...

  9. 16 CFR 1702.11 - Product specifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Product specifications. 1702.11 Section 1702.11 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION...

  10. 16 CFR 1702.12 - Packaging specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Packaging specifications. 1702.12 Section 1702.12 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION...

  11. 16 CFR 1702.11 - Product specifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Product specifications. 1702.11 Section 1702.11 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION...

  12. Pairing and specific heat in hot nuclei

    NASA Astrophysics Data System (ADS)

    Gambacurta, Danilo; Lacroix, Denis; Sandulescu, N.

    2013-09-01

    The thermodynamics of pairing phase-transition in nuclei is studied in the canonical ensemble and treating the pairing correlations in a finite-temperature variation after projection BCS approach (FT-VAP). Due to the restoration of particle number conservation, the pairing gap and the specific heat calculated in the FT-VAP approach vary smoothly with the temperature, indicating a gradual transition from the superfluid to the normal phase, as expected in finite systems. We have checked that the predictions of the FT-VAP approach are very accurate when compared to the results obtained by an exact diagonalization of the pairing Hamiltonian. The influence of pairing correlations on specific heat is analyzed for the isotopes 161,162Dy and 171,172Yb. It is shown that the FT-VAP approach, applied with a level density provided by mean field calculations and supplemented, at high energies, by the level density of the back-shifted Fermi gas model, can approximate reasonably well the main properties of specific heat extracted from experimental data. However, the detailed shape of the calculated specific heat is rather sensitive to the assumption made for the mean field.

  13. Educational Specifications: Milton J. Brecht Elementary School.

    ERIC Educational Resources Information Center

    Manheim Township School District, Lancaster, PA.

    This document presents recommended facility specifications for the Milton J. Brecht Elementary School (Lancaster, Pennsylvania) designed to contribute to children's learning through the application of multiple intelligence theory and more recently emerging brain based learning knowledge and theory. The report examines the grade levels to be…

  14. 9 CFR 590.100 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Specific exemptions. 590.100 Section 590.100 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION INSPECTION OF EGGS AND EGG PRODUCTS (EGG PRODUCTS INSPECTION ACT) Exemptions §...

  15. 9 CFR 590.100 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Specific exemptions. 590.100 Section 590.100 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION INSPECTION OF EGGS AND EGG PRODUCTS (EGG PRODUCTS INSPECTION ACT) Exemptions §...

  16. 9 CFR 590.100 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Specific exemptions. 590.100 Section 590.100 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION INSPECTION OF EGGS AND EGG PRODUCTS (EGG PRODUCTS INSPECTION ACT) Exemptions §...

  17. 9 CFR 590.100 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Specific exemptions. 590.100 Section 590.100 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION INSPECTION OF EGGS AND EGG PRODUCTS (EGG PRODUCTS INSPECTION ACT) Exemptions §...

  18. Radiotherapy supports protective tumor-specific immunity

    PubMed Central

    Gupta, Anurag; Sharma, Anu; von Boehmer, Lotta; Surace, Laura; Knuth, Alexander; van den Broek, Maries

    2012-01-01

    Radiotherapy is an important therapeutic option for the treatment of cancer. Growing evidence indicates that, besides inducing an irreversible DNA damage, radiotherapy promotes tumor-specific immune response, which significantly contribute to therapeutic efficacy. We postulate that radiotherapy activates tumor-associated dendritic cells, thus changing the tolerogenic tumor environment into an immunogenic one. PMID:23264910

  19. 41 CFR 101-29.201 - Specification.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Specification. 101-29.201 Section 101-29.201 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 29-FEDERAL PRODUCT DESCRIPTIONS...

  20. 37 CFR 102.34 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .../DEPT-14; (D) Attorneys and Agents Registered to Practice Before the Office—COMMERCE/PAT-TM-1; (E... OF COMMERCE ADMINISTRATION DISCLOSURE OF GOVERNMENT INFORMATION Privacy Act § 102.34 Specific... are within this exemption are: COMMERCE/PAT-TM-6, COMMERCE/PAT-TM-7, COMMERCE/PAT-TM-8,...

  1. 76 FR 15212 - Operations Specifications; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-21

    ... Federal Aviation Administration 14 CFR Part 129 RIN 2120-AJ45 Operations Specifications; Correction AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule; correction. SUMMARY: The FAA is correcting... document. DATES: The final rule and this correction will become effective on April 11, 2011. FOR...

  2. Specific Impulses Losses in Solid Propellant Rockets

    DTIC Science & Technology

    1974-12-17

    to use the collision function form proposed by Golovin to simplify this production term: 4C><=) <P- .: Accordingly: m hence, by integration: Now, we...November 21, 1940 in Paris, Seine. VFirst Thesis. "Contribution to the Study of Specific i Impulse Loss in Solid Propellant Rockets." Second Thesis

  3. 14 CFR 129.11 - Operations specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Commercial Air Transport) of Annex 6 (Operation of Aircraft) to the Convention on International Civil Aviation Organization. Operations specifications shall include: (1) Airports to be used; (2) Routes or... 129.11 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION...

  4. 37 CFR 102.34 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .../DEPT-14; (D) Attorneys and Agents Registered to Practice Before the Office—COMMERCE/PAT-TM-1; (E... OF COMMERCE ADMINISTRATION DISCLOSURE OF GOVERNMENT INFORMATION Privacy Act § 102.34 Specific exemptions. (a)(1) Some systems of records under the Act which are maintained by USPTO contain, from...

  5. 28 CFR 0.101 - Specific functions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the enforcement of their drug abuse laws. (b) The development and maintenance of a National Narcotics... Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE Drug Enforcement Administration § 0.101 Specific functions. The Administrator of the Drug Enforcement Administration shall...

  6. Site Specific Evaluation of Multisensor Capacitance Probes

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Multisensor capacitance probes (MCPs) are widely used for measuring soil water content (SWC) at the field scale. Although manufacturers supply a generic MCP calibration, many researchers recognize that MCPs should be calibrated for specific field conditions. MCPs measurements are typically associa...

  7. 31 CFR 596.309 - Specific license.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Specific license. 596.309 Section 596.309 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY TERRORISM LIST GOVERNMENTS SANCTIONS...

  8. Sedentary behavior and residual-specific mortality

    PubMed Central

    Loprinzi, Paul D.; Edwards, Meghan K.; Sng, Eveleen; Addoh, Ovuokerie

    2016-01-01

    Background: The purpose of this study was to examine the association of accelerometer-assessed sedentary behavior and residual-specific mortality. Methods: Data from the 2003-2006 National Health and Nutrition Examination Survey (NHANES) were used (N = 5536), with follow-up through 2011. Sedentary behavior was objectively measured over 7 days via accelerometry. Results: When expressing sedentary behavior as a 60 min/day increase, the hazard ratio across the models ranged from 1.07-1.40 (P < 0.05). There was evidence of an interaction effect between sedentary behavior and total physical activity on residual-specific mortality (Hazard ratiointeraction [HR] = 0.9989; 95% CI: 0.9982-0.9997; P = 0.008). Conclusion: Sedentary behavior was independently associated with residual-specific mortality. However, there was evidence to suggest that residual-specific mortality risk was a function of sedentary behavior and total physical activity. These findings highlight the need for future work to not only examine the association between sedentary behavior and health independent of total physical activity, but evaluate whether there is a joint effect of these two parameters on health. PMID:27766237

  9. Teaching Case: Enterprise Architecture Specification Case Study

    ERIC Educational Resources Information Center

    Steenkamp, Annette Lerine; Alawdah, Amal; Almasri, Osama; Gai, Keke; Khattab, Nidal; Swaby, Carval; Abaas, Ramy

    2013-01-01

    A graduate course in enterprise architecture had a team project component in which a real-world business case, provided by an industry sponsor, formed the basis of the project charter and the architecture statement of work. The paper aims to share the team project experience on developing the architecture specifications based on the business case…

  10. 30 CFR 22.7 - Specific requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... APPROVAL OF MINING PRODUCTS PORTABLE METHANE DETECTORS § 22.7 Specific requirements. (a) Design. In the... shall be of such design that it will not produce sparks that will ignite an explosive mixture of methane and air. (5) Detectors of the flame type. Methane detectors of the flame type shall be subject to...

  11. 46 CFR 171.115 - Specific applicability.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Specific applicability. 171.115 Section 171.115 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO VESSELS CARRYING PASSENGERS Openings in the Side of a Vessel Below the Bulkhead or Weather...

  12. 46 CFR 171.115 - Specific applicability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Specific applicability. 171.115 Section 171.115 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO VESSELS CARRYING PASSENGERS Openings in the Side of a Vessel Below the Bulkhead or Weather...

  13. 46 CFR 171.115 - Specific applicability.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Specific applicability. 171.115 Section 171.115 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO VESSELS CARRYING PASSENGERS Openings in the Side of a Vessel Below the Bulkhead or Weather...

  14. 46 CFR 171.115 - Specific applicability.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Specific applicability. 171.115 Section 171.115 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO VESSELS CARRYING PASSENGERS Openings in the Side of a Vessel Below the Bulkhead or Weather...

  15. Isotope specific arbitrary material flow meter

    DOEpatents

    Barty, Christopher P. J.; Post, John C.; Jones, Edwin

    2016-10-25

    A laser-based mono-energetic gamma-ray source is used to provide non-destructive and non-intrusive, quantitative determination of the absolute amount of a specific isotope contained within pipe as part of a moving fluid or quasi-fluid material stream.

  16. Prostate-specific antigen (PSA) blood test

    MedlinePlus

    Prostate-specific antigen; Prostate cancer screening test; PSA ... special steps are needed to prepare for this test. ... Reasons for a PSA test: This test may be done to screen for prostate cancer. It is also used to follow people after prostate cancer ...

  17. Specificity of aequorin luminescence to calcium

    NASA Technical Reports Server (NTRS)

    Shimomura, O.; Johnson, F. H.

    1975-01-01

    The presence of Pb(++), Co(++), Cu(++), and Cd(++), each of which possesses a certain luminescence-triggering activity of aequorin, potentially interferes with the specificity of the aequorin luminescence response to Ca(++). Interference by the above cations can be eliminated, without influencing the sensitivity of the luminescence of aequorin to Ca(++), by adding 1 mM of sodium diethyldithiocarbamate.

  18. The Specific Analysis of Structural Equation Models

    ERIC Educational Resources Information Center

    McDonald, Roderick P.

    2004-01-01

    Conventional structural equation modeling fits a covariance structure implied by the equations of the model. This treatment of the model often gives misleading results because overall goodness of fit tests do not focus on the specific constraints implied by the model. An alternative treatment arising from Pearl's directed acyclic graph theory…

  19. Specific Language Impairment at Adolescence: Avoiding Complexity

    ERIC Educational Resources Information Center

    Tuller, Laurice; Henry, Celia; Sizaret, Eva; Barthez, Marie-Anne

    2012-01-01

    This study explores complex language in adolescents with specific language impairment (SLI) with the aim of finding out how aspects of language characteristic of typical syntactic development after childhood fare and, in particular, whether there is evidence that individuals with SLI avoid using structures whose syntactic derivation involves…

  20. Relations between Specific and General Word Learning

    ERIC Educational Resources Information Center

    Davis, Claire; Drouin, Michelle

    2010-01-01

    A one-year longitudinal study was performed to test the hypothesis that children's word-specific learning of regular words is a causal determinate in their understanding and use of simple correspondence rules in reading and spelling. Kindergarten and first-grade children were asked to read and spell real words and matched pseudowords in three…

  1. 40 CFR 86.1513 - Fuel specifications.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 19 2014-07-01 2014-07-01 false Fuel specifications. 86.1513 Section 86.1513 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED..., and Liquefied Petroleum Gas-Fueled Diesel-Cycle Light-Duty Trucks; Idle Test Procedures § 86.1513...

  2. 40 CFR 7.145 - Specific prohibitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Specific prohibitions. 7.145 Section 7.145 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL NONDISCRIMINATION IN PROGRAMS OR... respect to individuals of a particular age. (c) A recipient shall not choose a site or location of...

  3. Model Educational Specifications for Technology in Schools.

    ERIC Educational Resources Information Center

    Maryland State Dept. of Education, College Park. Office of Administration and Finance.

    This description of the Model Edspec, which can be used by itself or in conjunction with the "Format Guide of Educational Specifications," serves as a comprehensive planning tool for the selection and application of technology. The model is designed to assist schools in implementing the facilities development process, thereby making…

  4. Teacher's Corner: Conducting Specification Searches with Amos

    ERIC Educational Resources Information Center

    Schumacker, Randall E.

    2006-01-01

    Amos 5.0 (Arbuckle, 2003) permits exploratory specification searches for the best theoretical model given an initial model using the following fit function criteria: chi-square (C), chi-square--df (C--df), Akaike Information Criteria (AIC), Browne-Cudeck criterion (BCC), Bayes Information Criterion (BIC) , chi-square divided by the degrees of…

  5. 50 CFR 648.260 - Specifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION...: Commercial catch data; current estimates of fishing mortality and catch-per-unit-effort (CPUE); stock status... effect until superseded by the final rule implementing the current year's specifications, to ensure...

  6. 10 CFR 72.7 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Specific exemptions. 72.7 Section 72.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE General Provisions §...

  7. 10 CFR 72.7 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Specific exemptions. 72.7 Section 72.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE General Provisions §...

  8. 22 CFR 308.14 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Foreign Relations PEACE CORPS IMPLEMENTATION OF THE PRIVACY ACT OF 1974 § 308.14 Specific exemptions... Records Peace Corps Staff/Volunteers and ACTION staff. (1) Authority: 5 U.S.C. 552a (k)(1) (2) Reasons: To...; Legal Files—Staff, Volunteers and Applicants; Security Records—Peace Corps Staff/Volunteers and...

  9. Body-Specific Representations of Spatial Location

    ERIC Educational Resources Information Center

    Brunye, Tad T.; Gardony, Aaron; Mahoney, Caroline R.; Taylor, Holly A.

    2012-01-01

    The body specificity hypothesis (Casasanto, 2009) posits that the way in which people interact with the world affects their mental representation of information. For instance, right- versus left-handedness affects the mental representation of affective valence, with right-handers categorically associating good with rightward areas and bad with…

  10. XML Based Markup Languages for Specific Domains

    NASA Astrophysics Data System (ADS)

    Varde, Aparna; Rundensteiner, Elke; Fahrenholz, Sally

    A challenging area in web based support systems is the study of human activities in connection with the web, especially with reference to certain domains. This includes capturing human reasoning in information retrieval, facilitating the exchange of domain-specific knowledge through a common platform and developing tools for the analysis of data on the web from a domain expert's angle. Among the techniques and standards related to such work, we have XML, the eXtensible Markup Language. This serves as a medium of communication for storing and publishing textual, numeric and other forms of data seamlessly. XML tag sets are such that they preserve semantics and simplify the understanding of stored information by users. Often domain-specific markup languages are designed using XML, with a user-centric perspective. Standardization bodies and research communities may extend these to include additional semantics of areas within and related to the domain. This chapter outlines the issues to be considered in developing domain-specific markup languages: the motivation for development, the semantic considerations, the syntactic constraints and other relevant aspects, especially taking into account human factors. Illustrating examples are provided from domains such as Medicine, Finance and Materials Science. Particular emphasis in these examples is on the Materials Markup Language MatML and the semantics of one of its areas, namely, the Heat Treating of Materials. The focus of this chapter, however, is not the design of one particular language but rather the generic issues concerning the development of domain-specific markup languages.

  11. Comparing center-specific cumulative incidence functions.

    PubMed

    Fan, Ludi; Schaubel, Douglas E

    2016-01-01

    The competing risks data structure arises frequently in clinical and epidemiologic studies. In such settings, the cumulative incidence function is often used to describe the ultimate occurrence of a particular cause of interest. If the objective of the analysis is to compare subgroups of patients with respect to cumulative incidence, imbalance with respect to group-specific covariate distributions must generally be factored out, particularly in observational studies. This report proposes a measure to contrast center- (or, more generally group-) specific cumulative incidence functions (CIF). One such application involves evaluating organ procurement organizations with respect to the cumulative incidence of kidney transplantation. In this case, the competing risks include (i) death on the wait-list and (ii) removal from the wait-list. The proposed method assumes proportional cause-specific hazards, which are estimated through Cox models stratified by center. The proposed center effect measure compares the average CIF for a given center to the average CIF that would have resulted if that particular center had covariate pattern-specific cumulative incidence equal to that of the national average. We apply the proposed methods to data obtained from a national organ transplant registry.

  12. Understanding Bacteriophage Specificity in Natural Microbial Communities

    PubMed Central

    Koskella, Britt; Meaden, Sean

    2013-01-01

    Studying the coevolutionary dynamics between bacteria and the bacteriophage viruses that infect them is critical to understanding both microbial diversity and ecosystem functioning. Phages can play a key role in shaping bacterial population dynamics and can significantly alter both intra- and inter-specific competition among bacterial hosts. Predicting how phages might influence community stability and apparent competition, however, requires an understanding of how bacteria-phage interaction networks evolve as a function of host diversity and community dynamics. Here, we first review the progress that has been made in understanding phage specificity, including the use of experimental evolution, we then introduce a new dataset on natural bacteriophages collected from the phyllosphere of horse chestnut trees, and finally we highlight that bacterial sensitivity to phage is rarely a binary trait and that this variation should be taken into account and reported. We emphasize that there is currently insufficient evidence to make broad generalizations about phage host range in natural populations, the limits of phage adaptation to novel hosts, or the implications of phage specificity in shaping microbial communities. However, the combination of experimental and genomic approaches with the study of natural communities will allow new insight to the evolution and impact of phage specificity within complex bacterial communities. PMID:23478639

  13. Patient-specific models of cardiac biomechanics

    NASA Astrophysics Data System (ADS)

    Krishnamurthy, Adarsh; Villongco, Christopher T.; Chuang, Joyce; Frank, Lawrence R.; Nigam, Vishal; Belezzuoli, Ernest; Stark, Paul; Krummen, David E.; Narayan, Sanjiv; Omens, Jeffrey H.; McCulloch, Andrew D.; Kerckhoffs, Roy C. P.

    2013-07-01

    Patient-specific models of cardiac function have the potential to improve diagnosis and management of heart disease by integrating medical images with heterogeneous clinical measurements subject to constraints imposed by physical first principles and prior experimental knowledge. We describe new methods for creating three-dimensional patient-specific models of ventricular biomechanics in the failing heart. Three-dimensional bi-ventricular geometry is segmented from cardiac CT images at end-diastole from patients with heart failure. Human myofiber and sheet architecture is modeled using eigenvectors computed from diffusion tensor MR images from an isolated, fixed human organ-donor heart and transformed to the patient-specific geometric model using large deformation diffeomorphic mapping. Semi-automated methods were developed for optimizing the passive material properties while simultaneously computing the unloaded reference geometry of the ventricles for stress analysis. Material properties of active cardiac muscle contraction were optimized to match ventricular pressures measured by cardiac catheterization, and parameters of a lumped-parameter closed-loop model of the circulation were estimated with a circulatory adaptation algorithm making use of information derived from echocardiography. These components were then integrated to create a multi-scale model of the patient-specific heart. These methods were tested in five heart failure patients from the San Diego Veteran's Affairs Medical Center who gave informed consent. The simulation results showed good agreement with measured echocardiographic and global functional parameters such as ejection fraction and peak cavity pressures.

  14. 17 CFR 200.312 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Specific exemptions. 200.312 Section 200.312 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Regulations Pertaining to the Privacy of Individuals...

  15. Ultrahigh Specific Impulse Nuclear Thermal Propulsion

    SciTech Connect

    Anne Charmeau; Brandon Cunningham; Samim Anghaie

    2009-02-09

    Research on nuclear thermal propulsion systems (NTP) have been in forefront of the space nuclear power and propulsion due to their design simplicity and their promise for providing very high thrust at reasonably high specific impulse. During NERVA-ROVER program in late 1950's till early 1970's, the United States developed and ground tested about 18 NTP systems without ever deploying them into space. The NERVA-ROVER program included development and testing of NTP systems with very high thrust (~250,000 lbf) and relatively high specific impulse (~850 s). High thrust to weight ratio in NTP systems is an indicator of high acceleration that could be achieved with these systems. The specific impulse in the lowest mass propellant, hydrogen, is a function of square root of absolute temperature in the NTP thrust chamber. Therefor optimizing design performance of NTP systems would require achieving the highest possible hydrogen temperature at reasonably high thrust to weight ratio. High hydrogen exit temperature produces high specific impulse that is a diret measure of propellant usage efficiency.

  16. 30 CFR 22.7 - Specific requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... APPROVAL OF MINING PRODUCTS PORTABLE METHANE DETECTORS § 22.7 Specific requirements. (a) Design. In the... shall be of such design that it will not produce sparks that will ignite an explosive mixture of methane and air. (5) Detectors of the flame type. Methane detectors of the flame type shall be subject to...

  17. 22 CFR 215.14 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Specific exemptions. 215.14 Section 215.14 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT REGULATIONS FOR IMPLEMENTATION OF PRIVACY ACT OF... may be asserted. The existence and general character of the information exempted will be made known...

  18. Evaluation of the Learning Path Specification

    ERIC Educational Resources Information Center

    Janssen, Jose; Berlanga, Adriana J.; Koper, Rob

    2011-01-01

    Flexible lifelong learning requires that learners can compare and select learning paths that best meet individual needs, not just in terms of learning goals, but also in terms of planning, costs etc. To this end a learning path specification was developed, which describes both the contents and the structure of any learning path, be it formal,…

  19. Metabolomics: Developing a chemical specific fingerprint

    USGS Publications Warehouse

    Putnam, Joel G.

    2016-01-01

    We combine cell assays and metabolomics to create a powerful tool, which emerges to elevate the identification of new control chemicals. We combined the use of bigheaded carp fry cell line with metabolite profiling to describe the dose response to thiram. Thiram is a registered pesticide commonly used as a fungicide in the field or as a seed protectant and is known to be toxic to fish. Seven concentrations of thiram were used to dose bighead carp fry cells and silver carp fry cells. We identified 700 metabolomic markers and 41 of those markers exhibited a dose response to thiram in the bighead carp fry cells. We identified 1590 metabolomic markers with 205 of those markers exhibited a dose response to thiram in the silver carp fry cells. When the metabolites of both cell lines are compared using volcano plots, 16 metabolomic markers were identified as significant. A smaller subset of metabolites indicate that a thiram specific metabolomic fingerprint exists that is not species specific, but instead toxin specific. Application of toxin fingerprints (toxin specific but species independent metabolites) can be used to address the cause of ecological significant events, such as mass fish kills.

  20. 48 CFR 836.202 - Specifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... specifications. (b) During the design stage, contract architect-engineers must not use “brand name or equal” or... OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Special Aspects of Contracting for... contracting officer must inform prospective architect-engineers of this requirement during the...

  1. 40 CFR 92.109 - Analyzer specifications.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Analyzer specifications. (a) General analyzer specifications—(1) Analyzer response time. Analyzers for THC... response time. (2) Precision. The precision of the analyzers for THC, CO2, CO, and NOX must be no greater... percent of full/scale chart deflection on all ranges used. (4) Zero drift. For THC, CO2, CO, and...

  2. 32 CFR 319.13 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PROGRAM DEFENSE INTELLIGENCE AGENCY PRIVACY PROGRAM § 319.13 Specific exemptions. (a) All systems of records maintained by the Director Intelligence Agency shall be exempt from the requirements of 5 U.S.C... has been properly classified. (b) The Director, Defense Intelligence Agency, designated the systems...

  3. 32 CFR 1901.63 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Specific exemptions. 1901.63 Section 1901.63 National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY PUBLIC RIGHTS... section (k) of the Privacy Act, the Director of Central Intelligence has determined to exempt from...

  4. 32 CFR 1901.63 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Specific exemptions. 1901.63 Section 1901.63 National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY PUBLIC RIGHTS... section (k) of the Privacy Act, the Director of Central Intelligence has determined to exempt from...

  5. 32 CFR 319.13 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... PROGRAM DEFENSE INTELLIGENCE AGENCY PRIVACY PROGRAM § 319.13 Specific exemptions. (a) All systems of records maintained by the Director Intelligence Agency shall be exempt from the requirements of 5 U.S.C... has been properly classified. (b) The Director, Defense Intelligence Agency, designated the systems...

  6. Early Language Milestones and Specific Language Impairment

    ERIC Educational Resources Information Center

    Rudolph, Johanna M.; Leonard, Laurence B.

    2016-01-01

    Delayed appearance of early language milestones can be one of the first signs of a developmental disorder. In this study, we investigated how well late acquisition of language milestones predicted an outcome of specific language impairment (SLI). The sample included 150 children (76 SLI), aged 4 to 7 years old. Milestone information was collected…

  7. 43 CFR 3811.2 - Lands: Specific.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Lands: Specific. 3811.2 Section 3811.2 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) LANDS AND MINERALS SUBJECT TO LOCATION Lands Subject...

  8. 43 CFR 3811.2 - Lands: Specific.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Lands: Specific. 3811.2 Section 3811.2 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) LANDS AND MINERALS SUBJECT TO LOCATION Lands Subject...

  9. 43 CFR 3811.2 - Lands: Specific.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Lands: Specific. 3811.2 Section 3811.2 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) LANDS AND MINERALS SUBJECT TO LOCATION Lands Subject...

  10. 43 CFR 3811.2 - Lands: Specific.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Lands: Specific. 3811.2 Section 3811.2 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) LANDS AND MINERALS SUBJECT TO LOCATION Lands Subject...

  11. Auxiliary Inversions and the Notion "Default Specification."

    ERIC Educational Resources Information Center

    Green, Georgia M.; Morgan, Jerry L.

    1996-01-01

    Demonstrates that a comprehensive account of inverted structures in English encompasses more diversity of structural types than is generally recognized and is possible in a constraint-based grammar with monotonic multiple-inheritance and no overridable default specifications. The article points out that the existence of such an account shows the…

  12. Processing Binding Relations in Specific Language Impairment

    ERIC Educational Resources Information Center

    Schwartz, Richard G.; Hestvik, Arild; Seiger-Gardner, Liat; Almodovar, Diana

    2016-01-01

    Purpose: This sentence processing experiment examined the abilities of children with specific language impairment (SLI) and children with typical language development (TD) to establish relations between pronouns or reflexives and their antecedents in real time. Method: Twenty-two children with SLI and 24 age-matched children with TD (7;3-10;11…

  13. Composing a Tumor Specific Bacterial Promoter

    PubMed Central

    Deyneko, Igor V.; Kasnitz, Nadine; Leschner, Sara; Weiss, Siegfried

    2016-01-01

    Systemically applied Salmonella enterica spp. have been shown to invade and colonize neoplastic tissues where it retards the growth of many tumors. This offers the possibility to use the bacteria as a vehicle for the tumor specific delivery of therapeutic molecules. Specificity of such delivery is solely depending on promoter sequences that control the production of a target molecule. We have established the functional structure of bacterial promoters that are transcriptionally active exclusively in tumor tissues after systemic application. We observed that the specific transcriptional activation is accomplished by a combination of a weak basal promoter and a strong FNR binding site. This represents a minimal set of control elements required for such activation. In natural promoters, additional DNA remodeling elements are found that alter the level of transcription quantitatively. Inefficiency of the basal promoter ensures the absence of transcription outside tumors. As a proof of concept, we compiled an artificial promoter sequence from individual motifs representing FNR and basal promoter and showed specific activation in a tumor microenvironment. Our results open possibilities for the generation of promoters with an adjusted level of expression of target proteins in particular for applications in bacterial tumor therapy. PMID:27171245

  14. 30 CFR 20.7 - Specific requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... APPROVAL OF MINING PRODUCTS ELECTRIC MINE LAMPS OTHER THAN STANDARD CAP LAMPS § 20.7 Specific requirements. Two general classes of electric lamps are recognized in these requirements, namely: Class 1, those...-contained and not so readily portable as the first class. (a) Class 1. Class 1 includes hand lamps,...

  15. 18 CFR 1301.24 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Specific exemptions. 1301.24 Section 1301.24 Conservation of Power and Water Resources TENNESSEE VALLEY AUTHORITY PROCEDURES... evidence, disclose investigative techniques or procedures, reduce the cooperativeness or safety...

  16. 18 CFR 1301.24 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Specific exemptions. 1301.24 Section 1301.24 Conservation of Power and Water Resources TENNESSEE VALLEY AUTHORITY PROCEDURES... evidence, disclose investigative techniques or procedures, reduce the cooperativeness or safety...

  17. 7 CFR 1.123 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Specific exemptions. 1.123 Section 1.123 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Privacy Act Regulations § 1.123... by agencies of USDA identified below are exempted from the provisions of 5 U.S.C. 552a (c)(3),...

  18. 78 FR 44894 - Specifications for Packagings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration 49 CFR Part 178 Specifications for Packagings CFR Correction 0 In Title 49 of the Code of Federal Regulations, Parts 178 to 199, revised as of October 1,...

  19. Microscale purification of antigen-specific antibodies

    PubMed Central

    Brown, Eric P.; Normandin, Erica; Osei-Owusu, Nana Yaw; Mahan, Alison E.; Chan, Ying N.; Lai, Jennifer I.; Vaccari, Monica; Rao, Mangala; Franchini, Genoveffa; Alter, Galit; Ackerman, Margaret E.

    2015-01-01

    Glycosylation of the Fc domain is an important driver of antibody effector function. While assessment of antibody glycoform compositions observed across total plasma IgG has identified differences associated with a variety of clinical conditions, in many cases it is the glycosylation state of only antibodies against a specific antigen or set of antigens that may be of interest, for example, in defining the potential effector function of antibodies produced during disease or after vaccination. Historically, glycoprofiling such antigen-specific antibodies in clinical samples has been challenging due to their low prevalence, the high sample requirement for most methods of glycan determination, and the lack of high-throughput purification methods. New methods of glycoprofiling with lower sample requirements and higher throughput have motivated the development of microscale and automatable methods for purification of antigen-specific antibodies from polyclonal sources such as clinical serum samples. In this work, we present a robot-compatible 96-well plate-based method for purification of antigen-specific antibodies, suitable for such population level glycosylation screening. We demonstrate the utility of this method across multiple antibody sources, using both purified plasma IgG and plasma, and across multiple different antigen types, with enrichment factors greater than 1000-fold observed. Using an on-column IdeS protease treatment, we further describe staged release of Fc and Fab domains, allowing for glycoprofiling of each domain. PMID:26078040

  20. Specification of the Model 3 General Lexicon.

    ERIC Educational Resources Information Center

    Rhode, Mary

    The Model 3 communication skills lexicon consists of three lists of words developed by the Southwest Regional Laboratory (SWRL) for use in communication skills instruction in K-6. This report documents the procedures followed in the specification and generation of the second component of the Model 3 communication skills lexicon, the general…