Science.gov

Sample records for aashto lrfd specifications

  1. Re-evaluation of the AASHTO-flexible pavement design equation with neural network modeling.

    PubMed

    Tiğdemir, Mesut

    2014-01-01

    Here we establish that equivalent single-axle loads values can be estimated using artificial neural networks without the complex design equality of American Association of State Highway and Transportation Officials (AASHTO). More importantly, we find that the neural network model gives the coefficients to be able to obtain the actual load values using the AASHTO design values. Thus, those design traffic values that might result in deterioration can be better calculated using the neural networks model than with the AASHTO design equation. The artificial neural network method is used for this purpose. The existing AASHTO flexible pavement design equation does not currently predict the pavement performance of the strategic highway research program (Long Term Pavement Performance studies) test sections very accurately, and typically over-estimates the number of equivalent single axle loads needed to cause a measured loss of the present serviceability index. Here we aimed to demonstrate that the proposed neural network model can more accurately represent the loads values data, compared against the performance of the AASHTO formula. It is concluded that the neural network may be an appropriate tool for the development of databased-nonparametric models of pavement performance. PMID:25397962

  2. Re-Evaluation of the AASHTO-Flexible Pavement Design Equation with Neural Network Modeling

    PubMed Central

    Tiğdemir, Mesut

    2014-01-01

    Here we establish that equivalent single-axle loads values can be estimated using artificial neural networks without the complex design equality of American Association of State Highway and Transportation Officials (AASHTO). More importantly, we find that the neural network model gives the coefficients to be able to obtain the actual load values using the AASHTO design values. Thus, those design traffic values that might result in deterioration can be better calculated using the neural networks model than with the AASHTO design equation. The artificial neural network method is used for this purpose. The existing AASHTO flexible pavement design equation does not currently predict the pavement performance of the strategic highway research program (Long Term Pavement Performance studies) test sections very accurately, and typically over-estimates the number of equivalent single axle loads needed to cause a measured loss of the present serviceability index. Here we aimed to demonstrate that the proposed neural network model can more accurately represent the loads values data, compared against the performance of the AASHTO formula. It is concluded that the neural network may be an appropriate tool for the development of databased-nonparametric models of pavement performance. PMID:25397962

  3. Re-evaluation of the AASHTO-flexible pavement design equation with neural network modeling.

    PubMed

    Tiğdemir, Mesut

    2014-01-01

    Here we establish that equivalent single-axle loads values can be estimated using artificial neural networks without the complex design equality of American Association of State Highway and Transportation Officials (AASHTO). More importantly, we find that the neural network model gives the coefficients to be able to obtain the actual load values using the AASHTO design values. Thus, those design traffic values that might result in deterioration can be better calculated using the neural networks model than with the AASHTO design equation. The artificial neural network method is used for this purpose. The existing AASHTO flexible pavement design equation does not currently predict the pavement performance of the strategic highway research program (Long Term Pavement Performance studies) test sections very accurately, and typically over-estimates the number of equivalent single axle loads needed to cause a measured loss of the present serviceability index. Here we aimed to demonstrate that the proposed neural network model can more accurately represent the loads values data, compared against the performance of the AASHTO formula. It is concluded that the neural network may be an appropriate tool for the development of databased-nonparametric models of pavement performance.

  4. Threaded connection limit state equations for use in LRFD tubular design

    SciTech Connect

    Schwind, B.E.; Chappell, J.F.; Katsounas, A.T.

    1995-12-31

    The purpose of the study was to identify and evaluate the variables that determine the leak resistance limit state functions of API 8-round and buttress connections. This work will be incorporated into Load and Resistance Factor Design (LRFD) equations. Connectors are an integral part any well design program. Therefore, it is vital that they be included in the LRFD design approach. Makeup, tension, internal pressure and dimensional data were among the variables in the evaluation, which was based on finite element analysis, testing and structural mechanics. The leak resistance limit state for round thread connections is defined by contact pressure, stab flank engaged length and coupling yield, while for buttress is defined by contact pressure, stab flank clearance and coupling yield. Leak pressure, as defined by API Bul. 5C3, is a function of makeup and dimensional data independent of thread type, tension, and pipe inside diameter and valid only in the elastic regime. Tension is detrimental in the leak resistance of 8-round connections, but does not compromise buttress leak resistance. Regression analysis was performed on structural mechanics results to produce the highest correlation to finite element results to account for end effects on round thread connections. It was determined by testing that stab flank contact over a minimum length of engagement is not sufficient to prevent 8-round leak, despite sufficient contact pressure level. Teflon impregnated thread compound should be the choice for API buttress. The indications are that optimized makeup should be considered in the leak resistance capacity of API connections.

  5. Bridge pier failure probabilities under combined hazard effects of scour, truck and earthquake. Part II: failure probabilities

    NASA Astrophysics Data System (ADS)

    Liang, Zach; Lee, George C.

    2013-06-01

    In many regions of the world, a bridge will experience multiple extreme hazards during its expected service life. The current American Association of State Highway and Transportation Officials (AASHTO) load and resistance factor design (LRFD) specifications are formulated based on failure probabilities, which are fully calibrated for dead load and non-extreme live loads. Design against earthquake load effect is established separately. Design against scour effect is also formulated separately by using the concept of capacity reduction (or increased scour depth). Furthermore, scour effect cannot be linked directly to an LRFD limit state equation because the latter is formulated using force-based analysis. This paper (in two parts) presents a probability-based procedure to estimate the combined hazard effects on bridges due to truck, earthquake and scour, by treating the effect of scour as an equivalent load effect so that it can be included in reliability-based failure calculations. In Part I of this series, the general principle for treating the scour depth as an equivalent load effect is presented. In Part II, the corresponding bridge failure probability, the occurrence of scour as well as simultaneously having both truck load and equivalent scour load effect are quantitatively discussed. The key formulae of the conditional partial failure probabilities and the necessary conditions are established. In order to illustrate the methodology, an example of dead, truck, earthquake and scour effects on a simple bridge pile foundation is represented.

  6. Towards multiple hazard resilient bridges: a methodology for modeling frequent and infrequent time-varying loads Part II, Examples for live and earthquake load effects

    NASA Astrophysics Data System (ADS)

    Liang, Zach; Lee, George C.

    2012-09-01

    The current AASHTO load and resistance factor design (LRFD) guidelines are formulated based on bridge reliability, which interprets traditional design safety factors into more rigorously deduced factors based on the theory of probability. This is a major advancement in bridge design specifications. However, LRFD is only calibrated for dead and live loads. In cases when extreme loads are significant, they need to be individually assessed. Combining regular loads with extreme loads has been a major challenge, mainly because the extreme loads are time variable and cannot be directly combined with time invariant loads to formulate the probability of structural failure. To overcome these difficulties, this paper suggests a methodology of comprehensive reliability, by introducing the concept of partial failure probability to separate the loads so that each individual load combination under a certain condition can be approximated as time invariant. Based on these conditions, the extreme loads (also referred to as multiple hazard or MH loads) can be broken down into single effects. In this paper, a further breakdown of these conditional occurrence probabilities into pure conditions is discussed by using a live truck and earthquake loads on a bridge as an example.

  7. Towards multiple hazard resilient bridges: a methodology for modeling frequent and infrequent time-varying loads Part I, Comprehensive reliability and partial failure probabilities

    NASA Astrophysics Data System (ADS)

    Liang, Zach; Lee, George C.

    2012-09-01

    The current AASHTO load and resistance factor design (LRFD) guidelines are formulated based on bridge reliability, which interprets traditional design safety factors into more rigorously deduced factors based on the theory of probability. This is a major advancement in bridge design specifications. However, LRFD is only calibrated for dead and live loads. In cases when extreme loads are significant, they need to be individually assessed. Combining regular loads with extreme loads has been a major challenge, mainly because the extreme loads are time variables and cannot be directly combined with time invariant loads to formulate the probability of structural failure. To overcome these difficulties, this paper suggests a methodology of comprehensive reliability, by introducing the concept of partial failure probability to separate the loads so that each individual load combination under a certain condition can be approximated as time invariant. Based on these conditions, the extreme loads (also referred to as multiple hazard or MH loads) can be broken down into single effects. In Part II of this paper, a further breakdown of these conditional occurrence probabilities into pure conditions is discussed by using a live truck and earthquake loads on a bridge as an example. There are three major steps in establishing load factors from MH load distributions: (1) formulate the failure probabilities; (2) normalize various load distributions; and (3) establish design limit state equations. This paper describes the formulation of the failure probabilities of single and combined loads.

  8. Bridge pier failure probabilities under combined hazard effects of scour, truck and earthquake. Part I: occurrence probabilities

    NASA Astrophysics Data System (ADS)

    Liang, Zach; Lee, George C.

    2013-06-01

    In many regions of the world, a bridge will experience multiple extreme hazards during its expected service life. The current American Association of State Highway and Transportation Officials (AASHTO) load and resistance factor design (LRFD) specifications are formulated based on failure probabilities, which are fully calibrated for dead load and nonextreme live loads. Design against earthquake loads is established separately. Design against scour effect is also formulated separately by using the concept of capacity reduction (or increased scour depth). Furthermore, scour effect cannot be linked directly to an LRFD limit state equation, because the latter is formulated using force-based analysis. This paper (in two parts) presents a probability-based procedure to estimate the combined hazard effects on bridges due to truck, earthquake and scour, by treating the effect of scour as an equivalent load effect so that it can be included in reliability-based bridge failure calculations. In Part I of this series, the general principle of treating the scour depth as an equivalent load effect is presented. The individual and combined partial failure probabilities due to truck, earthquake and scour effects are described. To explain the method of including non-force-based natural hazards effects, two types of common scour failures are considered. In Part II, the corresponding bridge failure probability, the occurrence of scour as well as simultaneously having both truck load and equivalent scour load are quantitatively discussed.

  9. Tests and specifications pertinent to coal ash utilization

    SciTech Connect

    Manz, O.

    1994-12-31

    Fortunately, in the United States, most of the test methods and specifications for the use of coal ash in cement, concrete, lime, or soil-related products are found in the American Society for Testing and Materials (ASTM) books of standards. Many of the same or slightly different specifications are also found in the American Association of State Highway and Transportation Officials (AASHTO) books of standards, as well as those of the various Departments of Transportation (DOTs). Other specifications for selected uses are found in publications of the American Petroleum Institute (API), the Sulfur Institute, the mineral wool industry, and West Virginia University. It is difficult to keep up with the most recent printed specifications, particularly in ASTM, since the committees meet twice yearly and have many time-consuming ballots. This paper summarizes the critical engineering properties required to assess the utilization applications of coal ash products. For most uses, both physical and chemical limits are specified. There are specifications for blended cement containing fly ash, for sulfate resistance, and for alkali aggregate reaction, also for fly ash for use in concrete, in oil well cement, and in grout. Coal ash is specified for use in ash-lime stabilization, as lightweight aggregate, and for mineral filler, as well as for structural fill and flowable fill. Other uses include sulfur concrete, high flexural strength ceramics, mineral wool, brick, cenospheres, and filler.

  10. A Brillouin smart FRP material and a strain data post processing software for structural health monitoring through laboratory testing and field application on a highway bridge

    NASA Astrophysics Data System (ADS)

    Bastianini, Filippo; Matta, Fabio; Galati, Nestore; Nanni, Antonio

    2005-05-01

    Strain and temperature sensing obtained through frequency shift evaluation of Brillouin scattered light is a technology that seems extremely promising for Structural Health Monitoring (SHM). Due to the intrinsic distributed sensing capability, Brillouin can measure the deformation of any individual segment of huge lengths of inexpensive single-mode fiber. In addition, Brillouin retains other typical advantages of Fiber Optic Sensors (FOS), such as harsh environment durability and interference rejection. Despite these advantages, the diffusion of Brillouin for SHM is constrained by different factors, such as the high equipment cost, the commercial unavailability of specific SHM oriented fiber products and even some prejudices on the required sensitivity performances. In the present work, a complete SHM pilot application was developed, installed and successfully operated during a diagnostic load test on the High Performance Steel (HPS) bridge A6358 located at the Lake of the Ozarks (Miller County, MO, USA). Four out of five girders were extensively instrumented with a "smart" Glass Fiber Reinforced Polymer (GFRP) tape having embedded fibers for strain sensing and thermal compensation. Data collected during a diagnostic load test were elaborated through a specific post-processing software, and the strain profiles retrieved were compared to traditional strain gauges and theoretical results based on the AASHTO LRFD Bridge Design Specifications for structural assessment purposes. The excellent results obtained confirm the effectiveness of Brillouin SHM systems for the monitoring of real applications.

  11. Refinement of Strut-and-Tie Model for Reinforced Concrete Deep Beams.

    PubMed

    Panjehpour, Mohammad; Chai, Hwa Kian; Voo, Yen Lei

    2015-01-01

    Deep beams are commonly used in tall buildings, offshore structures, and foundations. According to many codes and standards, strut-and-tie model (STM) is recommended as a rational approach for deep beam analyses. This research focuses on the STM recommended by ACI 318-11 and AASHTO LRFD and uses experimental results to modify the strut effectiveness factor in STM for reinforced concrete (RC) deep beams. This study aims to refine STM through the strut effectiveness factor and increase result accuracy. Six RC deep beams with different shear span to effective-depth ratios (a/d) of 0.75, 1.00, 1.25, 1.50, 1.75, and 2.00 were experimentally tested under a four-point bending set-up. The ultimate shear strength of deep beams obtained from non-linear finite element modeling and STM recommended by ACI 318-11 as well as AASHTO LRFD (2012) were compared with the experimental results. An empirical equation was proposed to modify the principal tensile strain value in the bottle-shaped strut of deep beams. The equation of the strut effectiveness factor from AASHTTO LRFD was then modified through the aforementioned empirical equation. An investigation on the failure mode and crack propagation in RC deep beams subjected to load was also conducted.

  12. Refinement of Strut-and-Tie Model for Reinforced Concrete Deep Beams

    PubMed Central

    Panjehpour, Mohammad; Chai, Hwa Kian; Voo, Yen Lei

    2015-01-01

    Deep beams are commonly used in tall buildings, offshore structures, and foundations. According to many codes and standards, strut-and-tie model (STM) is recommended as a rational approach for deep beam analyses. This research focuses on the STM recommended by ACI 318-11 and AASHTO LRFD and uses experimental results to modify the strut effectiveness factor in STM for reinforced concrete (RC) deep beams. This study aims to refine STM through the strut effectiveness factor and increase result accuracy. Six RC deep beams with different shear span to effective-depth ratios (a/d) of 0.75, 1.00, 1.25, 1.50, 1.75, and 2.00 were experimentally tested under a four-point bending set-up. The ultimate shear strength of deep beams obtained from non-linear finite element modeling and STM recommended by ACI 318-11 as well as AASHTO LRFD (2012) were compared with the experimental results. An empirical equation was proposed to modify the principal tensile strain value in the bottle-shaped strut of deep beams. The equation of the strut effectiveness factor from AASHTTO LRFD was then modified through the aforementioned empirical equation. An investigation on the failure mode and crack propagation in RC deep beams subjected to load was also conducted. PMID:26110268

  13. Refinement of Strut-and-Tie Model for Reinforced Concrete Deep Beams.

    PubMed

    Panjehpour, Mohammad; Chai, Hwa Kian; Voo, Yen Lei

    2015-01-01

    Deep beams are commonly used in tall buildings, offshore structures, and foundations. According to many codes and standards, strut-and-tie model (STM) is recommended as a rational approach for deep beam analyses. This research focuses on the STM recommended by ACI 318-11 and AASHTO LRFD and uses experimental results to modify the strut effectiveness factor in STM for reinforced concrete (RC) deep beams. This study aims to refine STM through the strut effectiveness factor and increase result accuracy. Six RC deep beams with different shear span to effective-depth ratios (a/d) of 0.75, 1.00, 1.25, 1.50, 1.75, and 2.00 were experimentally tested under a four-point bending set-up. The ultimate shear strength of deep beams obtained from non-linear finite element modeling and STM recommended by ACI 318-11 as well as AASHTO LRFD (2012) were compared with the experimental results. An empirical equation was proposed to modify the principal tensile strain value in the bottle-shaped strut of deep beams. The equation of the strut effectiveness factor from AASHTTO LRFD was then modified through the aforementioned empirical equation. An investigation on the failure mode and crack propagation in RC deep beams subjected to load was also conducted. PMID:26110268

  14. Towards establishing practical multi-hazard bridge design limit states

    NASA Astrophysics Data System (ADS)

    Liang, Zach; Lee, George C.

    2013-09-01

    In the U.S., the current Load and Resistance Factor Design (LRFD) Specifications for highway bridges is a reliability-based formulation that considers failure probabilities of bridge components due to the actions of typical dead load and frequent vehicular loads. Various extreme load effects, such as earthquake and vessel collision, are not considered on the same reliability-based platform. Since these extreme loads are time variables, combining them with frequent, nonextreme loads is a significant challenge. The number of design limit state equations based on these failure probabilities can be unrealistically large and unnecessary from the view point of practical applications. Based on the opinion of AASHTO State Bridge Engineers, many load combinations are insignificant in their states. This paper describes the formulation of a criterion to include only the necessary load combinations to establish the design limit states. This criterion is established by examining the total failure probabilities for all possible time-invariant and time varying load combinations and breaking them down into partial terms. Then, important load combinations can be readily determined quantitatively.

  15. Safety Identifying of Integral Abutment Bridges under Seismic and Thermal Loads

    PubMed Central

    Easazadeh Far, Narges; Barghian, Majid

    2014-01-01

    Integral abutment bridges (IABs) have many advantages over conventional bridges in terms of strength and maintenance cost. Due to the integrity of these structures uniform thermal and seismic loads are known important ones on the structure performance. Although all bridge design codes consider temperature and earthquake loads separately in their load combinations for conventional bridges, the thermal load is an “always on” load and, during the occurrence of an earthquake, these two important loads act on bridge simultaneously. Evaluating the safety level of IABs under combination of these loads becomes important. In this paper, the safety of IABs—designed by AASHTO LRFD bridge design code—under combination of thermal and seismic loads is studied. To fulfill this aim, first the target reliability indexes under seismic load have been calculated. Then, these analyses for the same bridge under combination of thermal and seismic loads have been repeated and the obtained reliability indexes are compared with target indexes. It is shown that, for an IAB designed by AASHTO LRFD, the indexes have been reduced under combined effects. So, the target level of safety during its design life is not provided and the code's load combination should be changed. PMID:25405232

  16. Safety identifying of integral abutment bridges under seismic and thermal loads.

    PubMed

    Easazadeh Far, Narges; Barghian, Majid

    2014-01-01

    Integral abutment bridges (IABs) have many advantages over conventional bridges in terms of strength and maintenance cost. Due to the integrity of these structures uniform thermal and seismic loads are known important ones on the structure performance. Although all bridge design codes consider temperature and earthquake loads separately in their load combinations for conventional bridges, the thermal load is an "always on" load and, during the occurrence of an earthquake, these two important loads act on bridge simultaneously. Evaluating the safety level of IABs under combination of these loads becomes important. In this paper, the safety of IABs--designed by AASHTO LRFD bridge design code--under combination of thermal and seismic loads is studied. To fulfill this aim, first the target reliability indexes under seismic load have been calculated. Then, these analyses for the same bridge under combination of thermal and seismic loads have been repeated and the obtained reliability indexes are compared with target indexes. It is shown that, for an IAB designed by AASHTO LRFD, the indexes have been reduced under combined effects. So, the target level of safety during its design life is not provided and the code's load combination should be changed. PMID:25405232

  17. Safety identifying of integral abutment bridges under seismic and thermal loads.

    PubMed

    Easazadeh Far, Narges; Barghian, Majid

    2014-01-01

    Integral abutment bridges (IABs) have many advantages over conventional bridges in terms of strength and maintenance cost. Due to the integrity of these structures uniform thermal and seismic loads are known important ones on the structure performance. Although all bridge design codes consider temperature and earthquake loads separately in their load combinations for conventional bridges, the thermal load is an "always on" load and, during the occurrence of an earthquake, these two important loads act on bridge simultaneously. Evaluating the safety level of IABs under combination of these loads becomes important. In this paper, the safety of IABs--designed by AASHTO LRFD bridge design code--under combination of thermal and seismic loads is studied. To fulfill this aim, first the target reliability indexes under seismic load have been calculated. Then, these analyses for the same bridge under combination of thermal and seismic loads have been repeated and the obtained reliability indexes are compared with target indexes. It is shown that, for an IAB designed by AASHTO LRFD, the indexes have been reduced under combined effects. So, the target level of safety during its design life is not provided and the code's load combination should be changed.

  18. Military specifications

    NASA Technical Reports Server (NTRS)

    Reynolds, Philip

    1987-01-01

    The current situation relative to the military specification is that there is not one specific model of turbulence which people are using. Particular disagreement exists on how turbulence levels will vary with qualitative analysis. It does not tie one down to specifics. When it comes to flying quality specifications, many feel that one should stay with the definitions of the Cooper-Harper rating scale but allow the levels to shift depending on the level of turbulence. There is a ride quality specification in the MIL-SPEC having to do with flight control systems design that is related to a turbulence model. This spec (MIL-F8785C) and others are discussed.

  19. Building Specifications

    NASA Technical Reports Server (NTRS)

    1978-01-01

    The building in the top photo is the new home of the National Permanent Savings Bank in Washington, D.C., designed by Hartman-Cox Architects. Its construction was based on a money-saving method of preparing building specifications which derived from NASA technology developed to obtain quality construction while holding down cost of launch facilities, test centers and other structures. Written technical specifications spell out materials and components to be used on construction projects and identify the quality tests each item must pass. Specifications can have major impact on construction costs. Poorly formulated specifications can lead to unacceptable construction which must be replaced, unnecessarily high materials costs, safety hazards, disputes and often additional costs due to delays and litigation. NASA's Langley Research Center developed a novel approach to providing accurate, uniform, cost-effective specifications which can be readily updated to incorporate new building technologies. Called SPECSINTACT, it is a computerized - system accessible to all NASA centers involved in construction programs. The system contains a comprehensive catalog of master specifications applicable to many types of construction. It enables designers of any structure to call out relevant sections from computer storage and modify them to fit the needs of the project at hand. Architects and engineers can save time by concentrating their efforts on needed modifications rather than developing all specifications from scratch. Successful use of SPECSINTACT has led to a number of spinoff systems. One of the first was MASTERSPEC, developed from NASA's experience by Production Systems for Architects and Engineers, Inc., an organization established by the American Institute of Architects. MASTERSPEC, used in construction of the bank building pictured, follows the same basic format as SPECSINTACT and can be used in either automated or manual modes. The striking appearance of the bank

  20. Specifying Specification.

    PubMed

    Paulo, Norbert

    2016-03-01

    This paper tackles the accusation that applied ethics is no serious academic enterprise because it lacks theoretical bracing. It does so in two steps. In the first step I introduce and discuss a highly acclaimed method to guarantee stability in ethical theories: Henry Richardson's specification. The discussion shows how seriously ethicists take the stability of the connection between the foundational parts of their theories and their further development as well as their "application" to particular problems or cases. A detailed scrutiny of specification leads to the second step, where I use insights from legal theory to inform the debate around stability from that point of view. This view reveals some of specification's limitations. I suggest that, once specification is sufficiently specified, it appears astonishingly similar to deduction as used in legal theory. Legal theory also provides valuable insight into the functional range of deduction and its relation to other forms of reasoning. This leads to a richer understanding of stability in normative theories and to a smart division of labor between deduction and other forms of reasoning. The comparison to legal theory thereby provides a framework for how different methods such as specification, deduction, balancing, and analogy relate to one another. PMID:27157109

  1. Specifying Specification.

    PubMed

    Paulo, Norbert

    2016-03-01

    This paper tackles the accusation that applied ethics is no serious academic enterprise because it lacks theoretical bracing. It does so in two steps. In the first step I introduce and discuss a highly acclaimed method to guarantee stability in ethical theories: Henry Richardson's specification. The discussion shows how seriously ethicists take the stability of the connection between the foundational parts of their theories and their further development as well as their "application" to particular problems or cases. A detailed scrutiny of specification leads to the second step, where I use insights from legal theory to inform the debate around stability from that point of view. This view reveals some of specification's limitations. I suggest that, once specification is sufficiently specified, it appears astonishingly similar to deduction as used in legal theory. Legal theory also provides valuable insight into the functional range of deduction and its relation to other forms of reasoning. This leads to a richer understanding of stability in normative theories and to a smart division of labor between deduction and other forms of reasoning. The comparison to legal theory thereby provides a framework for how different methods such as specification, deduction, balancing, and analogy relate to one another.

  2. Specific Suspicion

    ERIC Educational Resources Information Center

    Taylor, Kelley R.

    2009-01-01

    This article discusses a recent case decided by the U.S. Supreme Court which highlights the importance of having specific suspicions of misbehavior before conducting a strip search. The case involves an eighth-grade female student who was being strip-searched by a middle school assistant principal, a school nurse, and an administrative assistant…

  3. Intent Specifications

    NASA Technical Reports Server (NTRS)

    Leveson, Nancy G.

    1995-01-01

    We have been investigating the implications of using abstractions based on intent rather than the aggregation and information-hiding abstractions commonly used in software en- gineering: Cognitive psychologists have shown that intent abstraction is consistent with human problem-solving processes. We believe that new types of specifications and designs based on this concept can assist in understanding and specifying requirements, capturing the most important design rationale information in an efficient and economical way, and supporting the process of identifying and analyzing required changes to minimize the introduction of errors. The goal of hierarchical abstraction is to allow both top-down and bottom-up reasoning about a complex system. In computer science, we have made much use of (1) part-whole abstractions where each level of a hierarchy represents an aggregation of the components at a lower level and of (2) information-hiding abstractions where each level contains the same conceptual information but hides some details about the concepts, that is, each level is a refinement of the information at a higher level.

  4. Mining Specifications: A Roadmap

    NASA Astrophysics Data System (ADS)

    Zeller, Andreas

    Recent advances in software validation and verification make it possible to widely automate whether a specification is satisfied. This progress is hampered, though, by the persistent difficulty of writing specifications. Are we facing a “specification crisis”? In this paper, I show how to alleviate the burden of writing specifications by reusing and extending specifications as mined from existing software and give an overview on the state of the art in specification mining, its origins, and its potential.

  5. Phobia - simple/specific

    MedlinePlus

    Anxiety disorder - phobia ... Specific phobias are a type of anxiety disorder in which a person may feel extremely anxious or has a ... when exposed to the object of fear. Specific phobias are a common mental disorder. Common phobias include ...

  6. Improved technical specifications

    SciTech Connect

    Hoffman, D.R.

    1994-12-31

    Improved technical specifications for nuclear power plants are outlined. The objectives of this work are to improve safety, provide a clearer understanding of safety significance, and ease NRC and industry administrative burdens. Line item improvements, bases, and implementation of the specifications are discussed.

  7. Prototype Facility Educational Specifications.

    ERIC Educational Resources Information Center

    Idaho State Div. of Professional-Technical Education, Boise.

    This document presents prototypical educational specifications to guide the building and renovation of Idaho vocational schools so they can help communities meet the advanced, professional-technical programs of the future. The specifications start with points to consider when determining school site suitability. The document then sets forth…

  8. Point specificity in acupuncture

    PubMed Central

    2012-01-01

    The existence of point specificity in acupuncture is controversial, because many acupuncture studies using this principle to select control points have found that sham acupoints have similar effects to those of verum acupoints. Furthermore, the results of pain-related studies based on visual analogue scales have not supported the concept of point specificity. In contrast, hemodynamic, functional magnetic resonance imaging and neurophysiological studies evaluating the responses to stimulation of multiple points on the body surface have shown that point-specific actions are present. This review article focuses on clinical and laboratory studies supporting the existence of point specificity in acupuncture and also addresses studies that do not support this concept. Further research is needed to elucidate the point-specific actions of acupuncture. PMID:22373514

  9. Specific Genetic Disorders

    MedlinePlus

    ... of Genetic Terms Definitions for genetic terms Specific Genetic Disorders Many human diseases have a genetic component. ... Condition in an Adult The Undiagnosed Diseases Program Genetic Disorders Achondroplasia Alpha-1 Antitrypsin Deficiency Antiphospholipid Syndrome ...

  10. VOST charcoal specification study

    SciTech Connect

    Foster, A.L.; Bursey, J.T.

    1995-07-01

    The volatile organic sampling train, SW-846 Method 0030, (VOST) is currently one of the leading methodology`s available for the sampling and analysis of volatile organic hazardous compounds from stationary sources at very low levels. The method does not identify a specific equivalent sorbent, nor the performance specifications which would allow determination of an equivalent. Lot 104 petroleum-based charcoal is no longer commercially available. Laboratories are presently using a wide range of substitutes with varying performance from batch to batch of charcoal. To provide performance specifications and identify a replacement for SKC Lot 104 charcoal, a VOST charcoal specification study was initiated. Performance, cost, ease of handling, and plentiful supply make Anasorb 747 a good choice for replacement of SKX Lot 104.

  11. Urine specific gravity test

    MedlinePlus

    ... The osmolality test may not be needed. Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your doctor about the meaning of your specific test results.

  12. Allergen-specific immunotherapy.

    PubMed

    Nelson, Harold S; Norman, Philip S

    2014-01-01

    Specific immunotherapy was introduced for the treatment of grass pollen-induced hay fever in 1911. The treatment was soon extended to other pollens as well as perennial allergens, and to the treatment of bronchial asthma. Definitive studies of its efficacy for both rhinitis and asthma came only many decades later. Understanding gradually emerged of the underlying immunologic mechanisms that include the generation of regulatory T lymphocytes, immune deviation from allergen-specific Th2 to Th1 responses, and a shift in allergen-specific antibody production from immunoglobulin (Ig) E to IgG4. Along with understanding of the immune basis came an appreciation that immunotherapy modifies allergic disease expression, producing protection against disease progression and symptomatic improvement that persists for years after the treatment is discontinued. Recent new directions for immunotherapy include sublingual administration of inhalant allergens and use of the oral route to treat food allergy.

  13. Lidar base specification

    USGS Publications Warehouse

    Heidemann, Hans Karl.

    2012-01-01

    Lidar is a fast evolving technology, and much has changed in the industry since the final draft of the “Lidar Base Specification Version 1.0” was written. Lidar data have improved in accuracy and spatial resolution, geospatial accuracy standards have been revised by the American Society for Photogrammetry and Remote Sensing (ASPRS), industry standard file formats have been expanded, additional applications for lidar have become accepted, and the need for interoperable data across collections has been realized. This revision to the “Lidar Base Specification Version 1.0” publication addresses those changes and provides continued guidance towards a nationally consistent lidar dataset.

  14. Facilities Specifications Guide.

    ERIC Educational Resources Information Center

    Athletic Business, 2000

    2000-01-01

    Provides line drawings of indoor and outdoor sporting fields reflecting the specifications and dimensional standards of each, including where additional information can be found. Sporting events from badminton, baseball, and basketball to lacrosse, swimming/diving, and volleyball are addressed. (GR)

  15. Task-specific Dystonias

    PubMed Central

    Torres-Russotto, Diego; Perlmutter, Joel S.

    2009-01-01

    Task-specific dystonias are primary focal dystonias characterized by excessive muscle contractions producing abnormal postures during selective motor activities that often involve highly skilled, repetitive movements. Historically these peculiar postures were considered psychogenic but have now been classified as forms of dystonia. Writer’s cramp is the most commonly identified task-specific dystonia and has features typical of this group of disorders. Symptoms may begin with lack of dexterity during performance of a specific motor task with increasingly abnormal posturing of the involved body part as motor activity continues. Initially, the dystonia may manifest only during the performance of the inciting task, but as the condition progresses it may also occur during other activities or even at rest. Neurological exam is usually unremarkable except for the dystonia-related abnormalities. Although the precise pathophysiology remains unclear, increasing evidence suggests reduced inhibition at different levels of the sensorimotor system. Symptomatic treatment options include oral medications, botulinum toxin injections, neurosurgical procedures, and adaptive strategies. Prognosis may vary depending upon body part involved and specific type of task affected. Further research may reveal new insights into the etiology, pathophysiology, natural history, and improved treatment of these conditions. PMID:18990127

  16. Sports-specific injuries.

    PubMed

    Plancher, K D; Minnich, J M

    1996-04-01

    Injuries to the upper extremities can happen in any sport. Injury patterns are common to specific sports. Understanding which injuries occur with these sports allows the examiner to diagnose and treat the athlete easily. This article reviews some of the injuries common in sports such as bicycling, golf, gymnastics, martial arts, racquet sports, and weightlifting.

  17. IDC System Specification Document.

    SciTech Connect

    Clifford, David J.

    2014-12-01

    This document contains the system specifications derived to satisfy the system requirements found in the IDC System Requirements Document for the IDC Reengineering Phase 2 project. Revisions Version Date Author/Team Revision Description Authorized by V1.0 12/2014 IDC Reengineering Project Team Initial delivery M. Harris

  18. [Pregnancy-specific dermatoses].

    PubMed

    Soutou, B; Aractingi, S

    2015-03-01

    Pregnancy-specific dermatoses include polymorphic eruption of pregnancy, atopic eczema of pregnancy, and pemphigoid gestationis. Intrahepatic cholestasis of pregnancy and impetigo herpetiformis are not real pregnancy-specific dermatoses but they are important to know considering the fetal and maternal risks. Polymorphic eruption of pregnancy is a pruritic disease that usually occurs in primiparous women during the last trimester of pregnancy. Atopic eczema of pregnancy is still controversial as an entity covering conditions with eczematous lesions, prurigo, or folliculitis, and inconstantly associated with a personal history of atopy. Skin biopsy with direct immunofluorescence or search for serum anti-BPAg1 (180kD) NC16a antibodies is mandatory in pruritic dermatoses of pregnancy in order to rule out pemphigoid gestationis. Serum bile salts levels should be tested whenever a generalized pruritus develops during pregnancy in order to rule out intrahepatic cholestasis. PMID:25194221

  19. NOSS altimeter algorithm specifications

    NASA Technical Reports Server (NTRS)

    Hancock, D. W.; Forsythe, R. G.; Mcmillan, J. D.

    1982-01-01

    A description of all algorithms required for altimeter processing is given. Each description includes title, description, inputs/outputs, general algebraic sequences and data volume. All required input/output data files are described and the computer resources required for the entire altimeter processing system were estimated. The majority of the data processing requirements for any radar altimeter of the Seasat-1 type are scoped. Additions and deletions could be made for the specific altimeter products required by other projects.

  20. Baseball-specific conditioning.

    PubMed

    Rhea, Matthew R; Bunker, Derek

    2009-09-01

    Baseball demands speed, power, and quickness. To perform at a high level, and avoid injuries that are common among baseball players, an evaluation of current trends in strength and conditioning practices is helpful. Based on the demands of the sport and the injury risks, qualified strength and conditioning professionals can develop effective baseball-specific conditioning programs. This commentary briefly covers historical aspects of baseball conditioning, recent injury trends, current practices among elite baseball professionals, and provides suggestions for future improvements in training.

  1. SPECIFIC HEAT INDICATOR

    DOEpatents

    Horn, F.L.; Binns, J.E.

    1961-05-01

    Apparatus for continuously and automatically measuring and computing the specific heat of a flowing solution is described. The invention provides for the continuous measurement of all the parameters required for the mathematical solution of this characteristic. The parameters are converted to logarithmic functions which are added and subtracted in accordance with the solution and a null-seeking servo reduces errors due to changing voltage drops to a minimum. Logarithmic potentiometers are utilized in a unique manner to accomplish these results.

  2. Data specifications for INSPIRE

    NASA Astrophysics Data System (ADS)

    Portele, Clemens; Woolf, Andrew; Cox, Simon

    2010-05-01

    In Europe a major recent development has been the entering in force of the INSPIRE Directive in May 2007, establishing an infrastructure for spatial information in Europe to support Community environmental policies, and policies or activities which may have an impact on the environment. INSPIRE is based on the infrastructures for spatial information established and operated by the 27 Member States of the European Union. The Directive addresses 34 spatial data themes needed for environmental applications, with key components specified through technical implementing rules. This makes INSPIRE a unique example of a legislative "regional" approach. One of the requirements of the INSPIRE Directive is to make existing spatial data sets with relevance for one of the spatial data themes available in an interoperable way, i.e. where the spatial data from different sources in Europe can be combined to a coherent result. Since INSPIRE covers a wide range of spatial data themes, the first step has been the development of a modelling framework that provides a common foundation for all themes. This framework is largely based on the ISO 19100 series of standards. The use of common generic spatial modelling concepts across all themes is an important enabler for interoperability. As a second step, data specifications for the first set of themes has been developed based on the modelling framework. The themes include addresses, transport networks, protected sites, hydrography, administrative areas and others. The data specifications were developed by selected experts nominated by stakeholders from all over Europe. For each theme a working group was established in early 2008 working on their specific theme and collaborating with the other working groups on cross-theme issues. After a public review of the draft specifications starting in December 2008, an open testing process and thorough comment resolution process, the draft technical implementing rules for these themes have been

  3. Component-specific modeling

    NASA Technical Reports Server (NTRS)

    Mcknight, R. L.

    1985-01-01

    Accomplishments are described for the second year effort of a 3-year program to develop methodology for component specific modeling of aircraft engine hot section components (turbine blades, turbine vanes, and burner liners). These accomplishments include: (1) engine thermodynamic and mission models; (2) geometry model generators; (3) remeshing; (4) specialty 3-D inelastic stuctural analysis; (5) computationally efficient solvers, (6) adaptive solution strategies; (7) engine performance parameters/component response variables decomposition and synthesis; (8) integrated software architecture and development, and (9) validation cases for software developed.

  4. Master Software Requirements Specification

    NASA Technical Reports Server (NTRS)

    Hu, Chaumin

    2003-01-01

    A basic function of a computational grid such as the NASA Information Power Grid (IPG) is to allow users to execute applications on remote computer systems. The Globus Resource Allocation Manager (GRAM) provides this functionality in the IPG and many other grids at this time. While the functionality provided by GRAM clients is adequate, GRAM does not support useful features such as staging several sets of files, running more than one executable in a single job submission, and maintaining historical information about execution operations. This specification is intended to provide the environmental and software functional requirements for the IPG Job Manager V2.0 being developed by AMTI for NASA.

  5. 310 Facility chemical specifications

    SciTech Connect

    Hagerty, K.J.

    1997-05-21

    The 300 area Treated Effluent Disposal Facility (TEDF) was designed and built to treat the waste water from the 300 area process sewer system. Several treatment technologies are employed to remove the trace quantities of contaminants in the stream, including iron coprecipitation, clarification, filtration, ion exchange, and ultra violet light/hydrogen peroxide oxidation of organics. The chemicals that will be utilized in the treatment process are hydrogen peroxide, sulfuric acid, sodium hydroxide, and ferric chloride. This document annotates the required chemical characteristics of TEDF bulk chemicals as well as the criteria that were used to establish these criteria. The chemical specifications in appendix B are generated from this information.

  6. Disease specific protein corona

    NASA Astrophysics Data System (ADS)

    Rahman, M.; Mahmoudi, M.

    2015-03-01

    It is now well accepted that upon their entrance into the biological environments, the surface of nanomaterials would be covered by various biomacromolecules (e.g., proteins and lipids). The absorption of these biomolecules, so called `protein corona', onto the surface of (nano)biomaterials confers them a new `biological identity'. Although the formation of protein coronas on the surface of nanoparticles has been widely investigated, there are few reports on the effect of various diseases on the biological identity of nanoparticles. As the type of diseases may tremendously changes the composition of the protein source (e.g., human plasma/serum), one can expect that amount and composition of associated proteins in the corona composition may be varied, in disease type manner. Here, we show that corona coated silica and polystyrene nanoparticles (after interaction with in the plasma of the healthy individuals) could induce unfolding of fibrinogen, which promotes release of the inflammatory cytokines. However, no considerable releases of inflammatory cytokines were observed for corona coated graphene sheets. In contrast, the obtained corona coated silica and polystyrene nanoparticles from the hypofibrinogenemia patients could not induce inflammatory cytokine release where graphene sheets do. Therefore, one can expect that disease-specific protein coronas can provide a novel approach for applying nanomedicine to personalized medicine, improving diagnosis and treatment of different diseases tailored to the specific conditions and circumstances.

  7. VOST charcoal specification study

    SciTech Connect

    Fuerst, R.G.; Foster, A.L.; Bursey, J.T.

    1996-12-31

    The volatile organic sampling train (VOST) is currently one the leading methodologies available for the sampling and analysis of volatile principal organic hazardous constituents (POHCs) and products of incomplete combustion (PICs) from stationary sources at very low levels. However, revisions to the original method are necessary to maintain VOST as a viable regulatory tool. To provide performance specifications and identify a replacement for SKC Lot 104 charcoal, a VOST charcoal specification study was initiated. The following carbon-based candidate sorbents were considered: Tenax-GR (a graphitized Tenax); a Petroleum-based Charcoal; Ambersorbe XE-340 (hydrophobic carbonized resin bead); Anasorb 747 (beaded active carbon with very regular pore size); Carbosieve{reg_sign} S-III (carbon molecular sieve); and a Beaded Activated Charcoal (BAC) (with a very regular pore size). The results indicated that Tenax-GR showed significantly poorer performance than the other candidates in preliminary experimental results. Ambersorb did not retain the gaseous volatile organic compounds tested as well as the others and recovery of vinyl chloride was very low at all levels of spiking. Carbosieve was eliminated as a candidate replacement because of cost and handling problems. The petroleum-based charcoal was eliminated because of difficulties in handling a finely-divided powder. The availability of Anasorb 747 proved to be the deciding factor between it and the BAC. Performance, cost, ease of handling, and plentiful supply make Anasorb{reg_sign} 747 a good choice for replacement of SKC Lot 104. 1 tab.

  8. Component-specific modeling

    NASA Technical Reports Server (NTRS)

    Mcknight, R. L.

    1984-01-01

    A series of interdisciplinary modeling and analysis techniques that were specialized to address three specific hot section components are presented. These techniques will incorporate data as well as theoretical methods from many diverse areas including cycle and performance analysis, heat transfer analysis, linear and nonlinear stress analysis, and mission analysis. Building on the proven techniques already available in these fields, the new methods developed will be integrated into computer codes to provide an accurate, efficient and unified approach to analyzing combustor burner liners, hollow air-cooled turbine blades and air-cooled turbine vanes. For these components, the methods developed will predict temperature, deformation, stress and strain histories throughout a complete flight mission.

  9. Cylinder Test Specification

    SciTech Connect

    Richard Catanach; Larry Hill; Herbert Harry; Ernest Aragon; Don Murk

    1999-10-01

    The purpose of the cylinder testis two-fold: (1) to characterize the metal-pushing ability of an explosive relative to that of other explosives as evaluated by the E{sub 19} cylinder energy and the G{sub 19} Gurney energy and (2) to help establish the explosive product equation-of-state (historically, the Jones-Wilkins-Lee (JWL) equation). This specification details the material requirements and procedures necessary to assemble and fire a typical Los Alamos National Laboratory (LANL) cylinder test. Strict adherence to the cylinder. material properties, machining tolerances, material heat-treatment and etching processes, and high explosive machining tolerances is essential for test-to-test consistency and to maximize radial wall expansions. Assembly and setup of the cylinder test require precise attention to detail, especially when placing intricate pin wires on the cylinder wall. The cylinder test is typically fired outdoors and at ambient temperature.

  10. Patient specific instrumentation.

    PubMed

    Lionberger, David R; Crocker, Catherine L; Chen, Vincent

    2014-09-01

    Patient specific instrumentation (PSI) has recently been developed as a replacement for traditional instrumentation in total knee arthroplasty (TKA). The study aim was to assess efficiency via the mean total OR time using the PSI versus computer-assisted (CAS) TKAs with accuracy as a secondary endpoint. Sixty patients were randomized to CAS or PSI. A formula was developed to derive a profit ratio (PR) that incorporated costs, revenue, and total OR time. The PSI cases were 1.45 times more profitable than CAS allowing for approximately 3 PSI cases versus 2 CAS cases in one 8 hour OR day. Results from this series show that PSI improves OR efficiency, but does not improve accuracy.

  11. 25 CFR Appendix B to Subpart D - Design Standards for the IRR Program

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Specifications for Highway Bridges, latest edition. 6. AASHTO Guidelines of Geometric Design of Very Low-Volume..., Design Standards for Highways. 12. 23 CFR part 630, Preconstruction Procedures. 13. 23 CFR part 633... 25 Indians 1 2013-04-01 2013-04-01 false Design Standards for the IRR Program B Appendix B...

  12. Intent Specifications: An Approach to Building Human-Centered Specifications

    NASA Technical Reports Server (NTRS)

    Leveson, Nancy G.

    1999-01-01

    This paper examines and proposes an approach to writing software specifications, based on research in systems theory, cognitive psychology, and human-machine interaction. The goal is to provide specifications that support human problem solving and the tasks that humans must perform in software development and evolution. A type of specification, called intent specifications, is constructed upon this underlying foundation.

  13. Specific language impairment.

    PubMed

    Kamhi, Alan G; Clark, Mary Kristen

    2013-01-01

    The acquisition of language is one of the most important achievements in young children, in part because most children appear to acquire language with little effort. Some children are not so fortunate, however. There is a large group of children who also have difficulty learning language, but do not have obvious neurological, cognitive, sensory, emotional, or environmental deficits. Clinicians often refer to these children as language disordered or language impaired. Researchers tend to refer to these children as specific language impaired (SLI). Children with SLI have intrigued researchers for many years because there is no obvious reason for their language learning difficulties. SLI has been found to be an enduring condition that begins in early childhood and often persists into adolescence and adulthood. The language problems of children with SLI are not limited to spoken language; they also affect reading and writing and thus much of academic learning. Knowledge of the characteristics of SLI should aid physicians, pediatricians, and early childhood specialists to identify these children during the preschool years and ensure that they receive appropriate services. With high-quality language intervention and literacy instruction, most children with SLI should be able to perform and function adequately in school and beyond. PMID:23622167

  14. Genotype Specification Language.

    PubMed

    Wilson, Erin H; Sagawa, Shiori; Weis, James W; Schubert, Max G; Bissell, Michael; Hawthorne, Brian; Reeves, Christopher D; Dean, Jed; Platt, Darren

    2016-06-17

    We describe here the Genotype Specification Language (GSL), a language that facilitates the rapid design of large and complex DNA constructs used to engineer genomes. The GSL compiler implements a high-level language based on traditional genetic notation, as well as a set of low-level DNA manipulation primitives. The language allows facile incorporation of parts from a library of cloned DNA constructs and from the "natural" library of parts in fully sequenced and annotated genomes. GSL was designed to engage genetic engineers in their native language while providing a framework for higher level abstract tooling. To this end we define four language levels, Level 0 (literal DNA sequence) through Level 3, with increasing abstraction of part selection and construction paths. GSL targets an intermediate language based on DNA slices that translates efficiently into a wide range of final output formats, such as FASTA and GenBank, and includes formats that specify instructions and materials such as oligonucleotide primers to allow the physical construction of the GSL designs by individual strain engineers or an automated DNA assembly core facility. PMID:26886161

  15. ADANS database specification

    SciTech Connect

    1997-01-16

    The purpose of the Air Mobility Command (AMC) Deployment Analysis System (ADANS) Database Specification (DS) is to describe the database organization and storage allocation and to provide the detailed data model of the physical design and information necessary for the construction of the parts of the database (e.g., tables, indexes, rules, defaults). The DS includes entity relationship diagrams, table and field definitions, reports on other database objects, and a description of the ADANS data dictionary. ADANS is the automated system used by Headquarters AMC and the Tanker Airlift Control Center (TACC) for airlift planning and scheduling of peacetime and contingency operations as well as for deliberate planning. ADANS also supports planning and scheduling of Air Refueling Events by the TACC and the unit-level tanker schedulers. ADANS receives input in the form of movement requirements and air refueling requests. It provides a suite of tools for planners to manipulate these requirements/requests against mobility assets and to develop, analyze, and distribute schedules. Analysis tools are provided for assessing the products of the scheduling subsystems, and editing capabilities support the refinement of schedules. A reporting capability provides formatted screen, print, and/or file outputs of various standard reports. An interface subsystem handles message traffic to and from external systems. The database is an integral part of the functionality summarized above.

  16. Genotype Specification Language.

    PubMed

    Wilson, Erin H; Sagawa, Shiori; Weis, James W; Schubert, Max G; Bissell, Michael; Hawthorne, Brian; Reeves, Christopher D; Dean, Jed; Platt, Darren

    2016-06-17

    We describe here the Genotype Specification Language (GSL), a language that facilitates the rapid design of large and complex DNA constructs used to engineer genomes. The GSL compiler implements a high-level language based on traditional genetic notation, as well as a set of low-level DNA manipulation primitives. The language allows facile incorporation of parts from a library of cloned DNA constructs and from the "natural" library of parts in fully sequenced and annotated genomes. GSL was designed to engage genetic engineers in their native language while providing a framework for higher level abstract tooling. To this end we define four language levels, Level 0 (literal DNA sequence) through Level 3, with increasing abstraction of part selection and construction paths. GSL targets an intermediate language based on DNA slices that translates efficiently into a wide range of final output formats, such as FASTA and GenBank, and includes formats that specify instructions and materials such as oligonucleotide primers to allow the physical construction of the GSL designs by individual strain engineers or an automated DNA assembly core facility.

  17. Development of high performance precast/prestressed bridge girders

    NASA Astrophysics Data System (ADS)

    Akhnoukh, Amin K.

    Demand continues to increase for bridges with long spans and shallow depths. Due to safety concerns, four-span overpasses are being replaced with two span overpasses to avoid placement of piers near the highway shoulders. In the meantime, the bridge profile is restricted due to existing businesses nearby. Thus, nearly the same superstructure depth must be used for double the span length. This dissertation focuses on topics aiming at providing precast prestressed concrete girders with the shallowest possible depth for a given span. It forms parts of larger projects conducted by the University of Nebraska for the Nebraska Department of Roads and for the Wire Reinforcement Institute. Specifically, the following issues were researched: (1) Use of 0.7 in. diameter Grade 270 ksi strands for pretensioning of precast concrete girders at a strand spacing of 2 inches by 2 inches. This arrangement gives nearly 190 percent of the prestressing with 0.5 in. diameter strands and nearly 135 percent with 0.6 in. strands. The research focuses on the required confinement steel to allow determination of transfer and development lengths according to current procedures in the AASHTO LRFD Bridge Design Specifications for smaller strands. (2) Develop a self consolidating concrete (SCC) mix, using Nebraska aggregates that will allow for a specified design strength at service of 15 ksi and a minimum strength at one day of 10 ksi, representing the demand at the time of release of the prestress to the concrete member. Prior to this study, standard concrete strength prevailing in Nebraska has been 8 ksi at service and 6.5 ksi at release. It was the goal of the research to keep the cost of materials as low as possible but not exceeding 250 per cubic yard, compared to the proprietary mixes that cost approximately four times this amount. (3) Use of 80 ksi welded wire reinforcement (WWR) as the auxiliary reinforcement for shear, web end splitting and flange confinement. This would result in higher

  18. Specification-Based Testing Via Domain Specific Language

    NASA Astrophysics Data System (ADS)

    Sroka, Michal; Nagy, Roman; Fisch, Dominik

    2014-12-01

    The article presents tCF (testCaseFramework) - a domain specific language with corresponding toolchain for specification-based software testing of embedded software. tCF is designed for efficient preparation of maintainable and intelligible test cases and for testing process automation, as it allows to generate platform specific test cases for various testing levels. The article describes the essential parts of the tCF meta-model and the applied concept of platform specific test cases generators.

  19. Let's Get Specific: Clear Specifications Save Time and Money.

    ERIC Educational Resources Information Center

    Gretton, William R., III

    1994-01-01

    The primary objective of the purchasing specification is to provide an accurate basis for obtaining a product or service that will satisfy a particular need at a reasonable cost. Describes material vs. performance specifications and brand-name or equal specifications. (MLF)

  20. Specificity and non-specificity in RNA–protein interactions

    PubMed Central

    Jankowsky, Eckhard; Harris, Michael E.

    2016-01-01

    Gene expression is regulated by complex networks of interactions between RNAs and proteins. Proteins that interact with RNA have been traditionally viewed as either specific or non-specific; specific proteins interact preferentially with defined RNA sequence or structure motifs, whereas non-specific proteins interact with RNA sites devoid of such characteristics. Recent studies indicate that the binary “specific vs. non-specific” classification is insufficient to describe the full spectrum of RNA–protein interactions. Here, we review new methods that enable quantitative measurements of protein binding to large numbers of RNA variants, and the concepts aimed as describing resulting binding spectra: affinity distributions, comprehensive binding models and free energy landscapes. We discuss how these new methodologies and associated concepts enable work towards inclusive, quantitative models for specific and non-specific RNA–protein interactions. PMID:26285679

  1. [What are specific performance weaknesses?].

    PubMed

    Remschmidt, H

    1987-06-01

    The term "specific developmental disorder" means localized deficits in very different functions contrasting fit in the general otherwise normal performance level of a child. These disorders are mostly looked upon in a developmental context and differentiated from acquired neuropsychological syndromes (e.g. aphasia, apraxia). The most important clinically relevant disorders are: the specific reading disability, the specific dyscalculia, other specific learning disabilities, the specific developmental language disorder, the specific retardation in the motor development, and multiple developmental retardations. In a population of all patients treated in institutions for children and adolescents, 30% show specific developmental disorders with a predominance of boys. There is no correlation between dyslexia and social class but it does exist for specific developmental language disorder and motor retardation. As to the etiology of specific developmental disorders, genetic factors, congenital or acquired cerebral dysfunctions, maturation or developmental retardation and cognitive variables are discussed. The multifactor-approach seems to be the best way of understanding specific developmental disorders, which are difficult to prove. PMID:2441253

  2. Variola Virus-Specific Diagnostic Assays: Characterization, Sensitivity, and Specificity

    PubMed Central

    Kondas, Ashley V.; Olson, Victoria A.; Li, Yu; Abel, Jason; Laker, Miriam; Rose, Laura; Wilkins, Kimberly; Turner, Jonathan; Kline, Richard

    2015-01-01

    A public health response relies upon rapid and reliable confirmation of disease by diagnostic assays. Here, we detail the design and validation of two variola virus-specific real-time PCR assays, since previous assays cross-reacted with newly identified cowpox viruses. The assay specificity must continually be reassessed as other closely related viruses are identified. PMID:25673790

  3. Variola virus-specific diagnostic assays: characterization, sensitivity, and specificity.

    PubMed

    Kondas, Ashley V; Olson, Victoria A; Li, Yu; Abel, Jason; Laker, Miriam; Rose, Laura; Wilkins, Kimberly; Turner, Jonathan; Kline, Richard; Damon, Inger K

    2015-04-01

    A public health response relies upon rapid and reliable confirmation of disease by diagnostic assays. Here, we detail the design and validation of two variola virus-specific real-time PCR assays, since previous assays cross-reacted with newly identified cowpox viruses. The assay specificity must continually be reassessed as other closely related viruses are identified.

  4. [Multilingualism and specific language impairment].

    PubMed

    Arkkila, Eva; Smolander, Sini; Laasonen, Marja

    2013-01-01

    Specific language impairment is one of the most common developmental disturbances in childhood. With the increase of the foreign language population group an increasing number of children assimilating several languages and causing concern in language development attend clinical examinations. Knowledge of factors underlying the specific language impairment and the specific impairment in general, special features of language development of those learning several languages, as well as the assessment and support of the linguistic skills of a multilingual child is essential. The risk of long-term problems and marginalization is high for children having specific language impairment.

  5. Response to "Transfer or Specificity?"

    ERIC Educational Resources Information Center

    Miller, Judith

    2007-01-01

    This article presents the author's response to "Transfer or Specificity?" and reports a research that supports a strong case for a fundamental motor skill as a precursor to two sport specific skills as in Gallahue and Ozmun's (2002) theoretical model of motor development. Reported changes in performance of the overarm throw are attributed to the…

  6. Specific Learning Difficulties in Mathematics.

    ERIC Educational Resources Information Center

    Weedon, Charles

    Specific difficulties in mathematics tend to receive much less attention than do parallel difficulties with language. Accordingly, as its contribution to an ongoing project on children's learning difficulties and what to do about them, the Tayside (Scotland) Region decided to focus on children's specific problems with mathematics/arithmetic and…

  7. Hanford Site environmental management specification

    SciTech Connect

    Grygiel, M.L.

    1998-06-10

    The US Department of Energy, Richland Operations Office (RL) uses this Hanford Site Environmental Management Specification (Specification) to document top-level mission requirements and planning assumptions for the prime contractors involved in Hanford Site cleanup and infrastructure activities under the responsibility of the US Department of Energy, Office of Environmental Management. This Specification describes at a top level the activities, facilities, and infrastructure necessary to accomplish the cleanup of the Hanford Site and assigns this scope to Site contractors and their respective projects. This Specification also references the key National Environmental Policy Act of 1969 (NEPA), Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA), and safety documentation necessary to accurately describe the cleanup at a summary level. The information contained in this document reflects RL`s application of values, priorities, and critical success factors expressed by those involved with and affected by the Hanford Site project. The prime contractors and their projects develop complete baselines and work plans to implement this Specification. These lower-level documents and the data that support them, together with this Specification, represent the full set of requirements applicable to the contractors and their projects. Figure 1-1 shows the relationship of this Specification to the other basic Site documents. Similarly, the documents, orders, and laws referenced in this specification represent only the most salient sources of requirements. Current and contractual reference data contain a complete set of source documents.

  8. The Development of Educational Specifications.

    ERIC Educational Resources Information Center

    North Carolina State Board of Education, Raleigh.

    This publication is intended to assist local boards of education, superintendents, and staff in the organization and development of educational specifications. It was written because most educators have little knowledge about the purpose, process, organization, or contents of the finished product (educational specifications). It provides a…

  9. Performance Specifications for Occupational Programs.

    ERIC Educational Resources Information Center

    Maryland State Dept. of Education, Baltimore. Div. of Career Technology and Adult Learning.

    This document lists and discusses the development of Maryland's performance specifications for occupational programs. The introduction explains the process used to develop performance standards and specifications for 10 career cluster majors that were identified by a task force of educators and employers as high-demand occupational areas in…

  10. Specificity of Exercise and Specificity of Training: A Subcellular Review

    ERIC Educational Resources Information Center

    McCafferty, William B.; Horvath, Steven M.

    1977-01-01

    Selection of proper competitive activities for athletes is discussed in relation to the acknowledged fact that cellular adaptation is dependent upon the specific program employed in training for competitive events. (MB)

  11. Quality specifications for reference methods.

    PubMed

    Thienpont, L M

    1999-11-01

    Reference methods are a key element to the objective of traceability in laboratory medicine. However, to serve this purpose adequately, minimum analytical quality specifications are required. Here, possible strategies for deriving such specifications are presented, being based on concepts developed before by a European Working Group. Distinction is made between "genuine requirements" for reference methods (direct calibration with primary reference materials; absence of sample-related effects) and "performance specifications" (limits for random, systematic and total error, the latter in association with the number of measurements). While the former requirements are considered as conditio sine-qua-non, the latter specifications should be variable, which means that they should be tailored to the specific application of the methods. In general, it is advocated to derive performance specifications for reference methods from desirable specifications of routine methods (analyte-related), although other models should not be ruled out beforehand. Further, it is recommended that reference laboratories make special efforts to demonstrate and maintain a uniform level of quality of reference methods.

  12. SSL: A software specification language

    NASA Technical Reports Server (NTRS)

    Austin, S. L.; Buckles, B. P.; Ryan, J. P.

    1976-01-01

    SSL (Software Specification Language) is a new formalism for the definition of specifications for software systems. The language provides a linear format for the representation of the information normally displayed in a two-dimensional module inter-dependency diagram. In comparing SSL to FORTRAN or ALGOL, it is found to be largely complementary to the algorithmic (procedural) languages. SSL is capable of representing explicitly module interconnections and global data flow, information which is deeply imbedded in the algorithmic languages. On the other hand, SSL is not designed to depict the control flow within modules. The SSL level of software design explicitly depicts intermodule data flow as a functional specification.

  13. Grade 6 Science Curriculum Specifications.

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Curriculum Branch.

    This material describes curriculum specifications for grade 6 science in Alberta. Emphases recommended are: (1) process skills (50%); (2) psychomotor skills (10%); (3) attitudes (10%); and (4) subject matter (30%). Priorities within each category are identified. (YP)

  14. Molecular Mechanisms of Synaptic Specificity

    PubMed Central

    Margeta, Milica A.; Shen, Kang

    2011-01-01

    Synapses are specialized junctions that mediate information flow between neurons and their targets. A striking feature of the nervous system is the specificity of its synaptic connections: an individual neuron will form synapses only with a small subset of available presynaptic and postsynaptic partners. Synaptic specificity has been classically thought to arise from homophilic or heterophilic interactions between adhesive molecules acting across the synaptic cleft. Over the past decade, many new mechanisms giving rise to synaptic specificity have been identified. Synapses can be specified by secreted molecules that promote or inhibit synaptogenesis, and their source can be a neighboring guidepost cell, not just presynaptic and postsynaptic neurons. Furthermore, lineage, fate, and timing of development can also play critical roles in shaping neural circuits. Future work utilizing large-scale screens will aim to elucidate the full scope of cellular mechanisms and molecular players that can give rise to synaptic specificity. PMID:19969086

  15. Are specific allergen sensitivities inherited?

    PubMed

    Misiak, Rana Tawil; Wegienka, Ganesa; Zoratti, Edward

    2010-09-01

    A family history of an allergic condition is a well-accepted risk factor for the development of an allergic condition in an individual, particularly for allergic disorders such as asthma, eczema, and allergic rhinitis. However, the question of whether specific allergen sensitization is inherited requires a complicated answer, as environmental exposure plays an important role in the development of allergen-specific IgE. This article summarizes the findings of recent studies in the literature regarding what is known about the inheritance of specific allergens. Overall, properly collected and analyzed data appear to both support and refute the hypothesis that specific allergen sensitization is inherited, even when attempting to account for the complexities of varying study methodologies and the evaluation of diverse populations and communities. PMID:20574668

  16. Electric motor model repair specifications

    SciTech Connect

    1995-08-01

    These model repair specifications list the minimum requirements for repair and overhaul of polyphase AC squireel cage induction motors. All power ranges, voltages, and speeds of squirrel cage motors are covered.

  17. Patient-specific surgical simulation.

    PubMed

    Soler, Luc; Marescaux, Jacques

    2008-02-01

    Technological innovations of the twentieth century have provided medicine and surgery with new tools for education and therapy definition. Thus, by combining Medical Imaging and Virtual Reality, patient-specific applications providing preoperative surgical simulation have become possible.

  18. Generic specifications for hybrid microcircuits

    NASA Astrophysics Data System (ADS)

    1987-04-01

    The general requirements for circuit-type approval, procurement, lot-acceptance testing, and delivery of thick and thin film hybrid microcircuits suitable for space application are specified. It is used in conjunction with the detail specification applicable to the actual circuit type and is valid only for procurement from manufacturers whose capability is approved by ESA in accordance with specifications ESA PSS-01-605 or ESA PSS-01-606.

  19. mREST Interface Specification

    NASA Technical Reports Server (NTRS)

    McCartney, Patrick; MacLean, John

    2012-01-01

    mREST is an implementation of the REST architecture specific to the management and sharing of data in a system of logical elements. The purpose of this document is to clearly define the mREST interface protocol. The interface protocol covers all of the interaction between mREST clients and mREST servers. System-level requirements are not specifically addressed. In an mREST system, there are typically some backend interfaces between a Logical System Element (LSE) and the associated hardware/software system. For example, a network camera LSE would have a backend interface to the camera itself. These interfaces are specific to each type of LSE and are not covered in this document. There are also frontend interfaces that may exist in certain mREST manager applications. For example, an electronic procedure execution application may have a specialized interface for configuring the procedures. This interface would be application specific and outside of this document scope. mREST is intended to be a generic protocol which can be used in a wide variety of applications. A few scenarios are discussed to provide additional clarity but, in general, application-specific implementations of mREST are not specifically addressed. In short, this document is intended to provide all of the information necessary for an application developer to create mREST interface agents. This includes both mREST clients (mREST manager applications) and mREST servers (logical system elements, or LSEs).

  20. Organ-Specific Membrane Antigens

    PubMed Central

    Sell, K. W.; Mori, W.; Rack, J. H.; Gurner, B. W.; Coombs, R. R. A.

    1969-01-01

    A satisfactory system for testing the reaction of rabbit antisera with membrane antigens of human tissue cells is described. This method allows the differentiation between IgG and IgM antibodies and provides an extremely sensitive method for the detection of antigens on all cells including non-viable fixed cells. Anti-organ serum before selective absorption showed very little organ specificity in their reactions, but may be made specific by extensive absorption although often the resulting specific titre was very low. Organ-specific membrane antigens were also identified and shown to be represented on tumour cells, although in some cases such as the colon the reactions were weaker with tumour cells than with normal parenchymal cells of an organ. On the other hand, in one case of carcinoma of the kidney the organ-specific antigens were detectably stronger on tumour cells than on normal kidney cells. Preliminary studies on human ascitic tumour cells from 4 different cancer patients show that species-specific membrane antigens can be demonstrated. Unfortunately none of the cases were derived from organs whose origin could be identified with the antisera which had been prepared for this series of experiments. ImagesFigs. 2-3 PMID:5806432

  1. Quantifying group specificity of animal vocalizations without specific sender information

    NASA Astrophysics Data System (ADS)

    Vester, Heike; Hammerschmidt, Kurt; Timme, Marc; Hallerberg, Sarah

    2016-02-01

    Recordings of animal vocalization can lack information about sender and context. This is often the case in studies on marine mammals or in the increasing number of automated bioacoustics monitorings. Here, we develop a framework to estimate group specificity without specific sender information. We introduce and apply a bag-of-calls-and-coefficients approach (BOCCA) to study ensembles of cepstral coefficients calculated from vocalization signals recorded from a given animal group. Comparing distributions of such ensembles of coefficients by computing relative entropies reveals group specific differences. Applying the BOCCA to ensembles of calls recorded from group of long-finned pilot whales in northern Norway, we find that differences of vocalizations within social groups of pilot whales (Globicephala melas) are significantly lower than intergroup differences.

  2. Quantifying group specificity of animal vocalizations without specific sender information.

    PubMed

    Vester, Heike; Hammerschmidt, Kurt; Timme, Marc; Hallerberg, Sarah

    2016-02-01

    Recordings of animal vocalization can lack information about sender and context. This is often the case in studies on marine mammals or in the increasing number of automated bioacoustics monitorings. Here, we develop a framework to estimate group specificity without specific sender information. We introduce and apply a bag-of-calls-and-coefficients approach (BOCCA) to study ensembles of cepstral coefficients calculated from vocalization signals recorded from a given animal group. Comparing distributions of such ensembles of coefficients by computing relative entropies reveals group specific differences. Applying the BOCCA to ensembles of calls recorded from group of long-finned pilot whales in northern Norway, we find that differences of vocalizations within social groups of pilot whales (Globicephala melas) are significantly lower than intergroup differences. PMID:26986319

  3. Velocity specificity, combination training and sport specific tasks.

    PubMed

    Cronin, J; McNair, P J; Marshall, R N

    2001-06-01

    Whether velocity-specific resistance training is important for improving functional sporting performance was investigated by studying the effect of isoinertial training velocity on netball chest pass throwing velocity. Twenty-one female netball players were randomly assigned to a strength-trained group (80% 1RM - average training velocity = .308 m/s), power-trained group (60% 1RM - average training velocity = .398 m/s) and a control group. Resistance training was combined with sport specific motion training for both groups over a ten-week training duration. Pre- and post-training testing revealed that the training velocity associated with the strength-trained group produced significantly greater improvement in mean volume of weight lifted (85kg) and mean power output (13.25 W) as compared to the power and control groups (P< 0.05). The strength-trained and power-trained groups significantly improved netball throw velocity by 12.4% and 8.8% respectively. There was no significant difference between the two groups. The validity of velocity-specific training and subsequent adaptations to improve functional sporting performance appears highly questionable, due to the disparity between training velocity and actual movement velocity (11.38 m x s(-1)) for a given sport specific task such as the netball throw it was proposed that the repeated intent to move an isoinertial load as rapidly as possible coupled with performance of the sport-specific movement promote efficient coordination and activation patterns. Such mechanisms might be more important determinants of sport-specific high velocity adaptation.

  4. Technical specification for vacuum systems

    SciTech Connect

    Khaw, J.

    1987-01-01

    The vacuum systems at the Stanford Linear Accelerator Center (SLAC) are primarily of all-metal construction and operate at pressures from 10/sup -5/ to 10/sup -11/ Torr. The primary gas loads during operation result from thermal desorption and beam-induced desorption from the vacuum chamber walls. These desorption rates can be extremely high in the case of hydrocarbons and other contaminants. These specifications place a major emphasis on eliminating contamination sources. The specifications and procedures have been written to insure the cleanliness and vacuum integrity of all SLAC vacuum systems, and to assist personnel involved with SLAC vacuum systems in choosing and designing components that are compatible with existing systems and meet the quality and reliability of SLAC vacuum standards. The specification includes requirements on design, procurement, fabrication, chemical cleaning, clean room practices, welding and brazing, helium leak testing, residual gas analyzer testing, bakeout, venting, and pumpdown. Also appended are specifications regarding acceptable vendors, isopropyl alcohol, bakeable valve cleaning procedure, mechanical engineering safety inspection, notes on synchrotron radiation, and specifications of numerous individual components. (LEW)

  5. Specificity of hammerhead ribozyme cleavage.

    PubMed Central

    Hertel, K J; Herschlag, D; Uhlenbeck, O C

    1996-01-01

    To be effective in gene inactivation, the hammerhead ribozyme must cleave a complementary RNA target without deleterious effects from cleaving non-target RNAs that contain mismatches and shorter stretches of complementarity. The specificity of hammerhead cleavage was evaluated using HH16, a well-characterized ribozyme designed to cleave a target of 17 residues. Under standard reaction conditions, HH16 is unable to discriminate between its full-length substrate and 3'-truncated substrates, even when six fewer base pairs are formed between HH16 and the substrate. This striking lack of specificity arises because all the substrates bind to the ribozyme with sufficient affinity so that cleavage occurs before their affinity differences are manifested. In contrast, HH16 does exhibit high specificity towards certain 3'-truncated versions of altered substrates that either also contain a single base mismatch or are shortened at the 5' end. In addition, the specificity of HH16 is improved in the presence of p7 nucleocapsid protein from human immunodeficiency virus (HIV)-1, which accelerates the association and dissociation of RNA helices. These results support the view that the hammerhead has an intrinsic ability to discriminate against incorrect bases, but emphasizes that the high specificity is only observed in a certain range of helix lengths. Images PMID:8670879

  6. 1997 hybrid electric vehicle specifications

    SciTech Connect

    Sluder, S.; Larsen, R.; Duoba, M.

    1996-10-01

    The US DOE sponsors Advanced Vehicle Technology competitions to help educate the public and advance new vehicle technologies. For several years, DOE has provided financial and technical support for the American Tour de Sol. This event showcases electric and hybrid electric vehicles in a road rally across portions of the northeastern United States. The specifications contained in this technical memorandum apply to vehicles that will be entered in the 1997 American Tour de Sol. However, the specifications were prepared to be general enough for use by other teams and individuals interested in developing hybrid electric vehicles. The purpose of the specifications is to ensure that the vehicles developed do not present a safety hazard to the teams that build and drive them or to the judges, sponsors, or public who attend the competitions. The specifications are by no means the definitive sources of information on constructing hybrid electric vehicles - as electric and hybrid vehicles technologies advance, so will the standards and practices for their construction. In some cases, the new standards and practices will make portions of these specifications obsolete.

  7. Compiler writing system detail design specification. Volume 1: Language specification

    NASA Technical Reports Server (NTRS)

    Arthur, W. J.

    1974-01-01

    Construction within the Meta language for both language and target machine specification is reported. The elements of the function language as a meaning and syntax are presented, and the structure of the target language is described which represents the target dependent object text representation of applications programs.

  8. Specific probiotics or 'fecal transplantation'.

    PubMed

    Kruis, Wolfgang

    2012-01-01

    The intestinal ecosystem consists mainly of the enteric flora and to a large extent determines intestinal but also extraintestinal health and disease. General alterations and specific molecular changes of intestinal bacteria cause local as well as systemic immune reactions. Nonantibiotic treatment of the enteric flora has a long tradition and spans a range of different interventions from nutrition to specific probiotics and complete fecal transplantation. When comparing therapy to specific probiotics and fecal transplantation, several aspects need to be considered, like biological consequences, safety and therapeutic evidence. The introduction of probiotics into therapy occurred more than hundred years ago. In contrast, experiences with fecal transplantation are more recent and more limited. Safety issues have not been definitively clarified. Because of the different biological activities of probiotics and fecal transplantation, it can be hypothesized that they may play different roles in the treatment of various diseases. More research is needed before the details, safety and therapeutic effects of bacteriotherapy for IBD become sufficiently clear.

  9. The specificity of social stress.

    PubMed

    Zayan, R

    1991-12-01

    This paper attempts to clarify the concept of "social stress" as implicitly understood in the ethological literature. With respect to the general characteristics of stressors and stress responses, the concept when applied to crowding or to encounters with unfamiliar conspecifics does not appear to denote a specific process. The concept is more specific when it refers to the psychological (emotional, perceptive or cognitive) processes that accompany "behavioural stress", e.g. agonistic interactions and subordination experience. The concept of "sociological stress" is proposed to denote the very specific process whereby stress responses of individuals result from a group's social structure, and whereby the former determine the latter via behavioural interactions and the other types of couplings (e.g. perceptive) between the group-members. Finally, it is submitted that social stress at the group level may not be adequately reflected by traditional hormonal indicators of physiological stress. PMID:24923968

  10. Application specific serial arithmetic arrays

    NASA Technical Reports Server (NTRS)

    Winters, K.; Mathews, D.; Thompson, T.

    1990-01-01

    High performance systolic arrays of serial-parallel multiplier elements may be rapidly constructed for specific applications by applying hardware description language techniques to a library of full-custom CMOS building blocks. Single clock pre-charged circuits have been implemented for these arrays at clock rates in excess of 100 Mhz using economical 2-micron (minimum feature size) CMOS processes, which may be quickly configured for a variety of applications. A number of application-specific arrays are presented, including a 2-D convolver for image processing, an integer polynomial solver, and a finite-field polynomial solver.

  11. Host Specificity of Bacterial Pathogens

    PubMed Central

    Bäumler, Andreas; Fang, Ferric C.

    2013-01-01

    Most pathogens are able to infect multiple hosts but some are highly adapted to a single-host species. A detailed understanding of the basis of host specificity can provide important insights into molecular pathogenesis, the evolution of pathogenic microbes, and the potential for pathogens to cross the species barrier to infect new hosts. Comparative genomics and the development of humanized mouse models have provided important new tools with which to explore the basis of generalism and specialism. This review will examine host specificity of bacterial pathogens with a focus on generalist and specialist serovars of Salmonella enterica. PMID:24296346

  12. High specific heat superconducting composite

    DOEpatents

    Steyert, Jr., William A.

    1979-01-01

    A composite superconductor formed from a high specific heat ceramic such as gadolinium oxide or gadolinium-aluminum oxide and a conventional metal conductor such as copper or aluminum which are insolubly mixed together to provide adiabatic stability in a superconducting mode of operation. The addition of a few percent of insoluble gadolinium-aluminum oxide powder or gadolinium oxide powder to copper, increases the measured specific heat of the composite by one to two orders of magnitude below the 5.degree. K. level while maintaining the high thermal and electrical conductivity of the conventional metal conductor.

  13. Procedures for evaluating technical specifications

    SciTech Connect

    Boccio, J.L.; Robinson, R.C.; Samanta, P.K.; Vesely, W.E.

    1987-01-01

    The Procedures for Evaluating Technical Specifications (PETS) Program being conducted by Brookhaven National Laboratory for the Office of Research, US Nuclear Regulatory Commission (NRC), is developing various risk-based approaches for modifying Technical Specifications (TS). This paper highlights the various risk-based issues being addressed by the program and presents examples that exemplify the use of PRA models for modifying TS, primarily elements of the Limiting Condition of Operation (LCOs) and Surveillance Requirements (SRs). PETS approaches to TS modification using more detailed analysis are presented in a companion paper.

  14. Practical Issues with Formal Specifications

    NASA Astrophysics Data System (ADS)

    Altenhofen, Michael; Brucker, Achim D.

    Many software companies still seem to be reluctant to use formal specifications in their development processes. Nevertheless, the trend towards implementing critical business applications in distributed environments makes such applications an attractive target for formal methods. Additionally, the rising complexity also increases the willingness of the development teams to apply formal techniques.

  15. Specificity of Cardiovascular Endurance Training.

    ERIC Educational Resources Information Center

    Riley, Calberth B., Jr.; Johnson, James H.

    This study determined the specificity of cardiovascular endurance training on a bicycle ergometer. Eighteen male subjects were tested on a heart rate response test of 150 beats per minute on a bicycle ergometer at the pace of 50 revolutions per minute (rpm) and at 160 beats per minute at 60 and 80 rpm, with the resistance equal to the force of…

  16. Priming the Query Specification Process.

    ERIC Educational Resources Information Center

    Toms, Elaine G.; Freund, Luanne

    2003-01-01

    Tests the use of questions as a technique in the query specification process. Using a within-subjects design, 48 people interacted with a modified Google interface to solve four information problems in four domains. Half the tasks were entered as typical keyword queries, and half as questions or statements. Results suggest the typical search box…

  17. Portable File Format (PFF) specifications.

    SciTech Connect

    Dolan, Daniel H.,

    2015-02-01

    Created at Sandia National Laboratories, the Portable File Format (PFF) allows binary data transfer across computer platforms. Although this capability is supported by many other formats, PFF files are still in use at Sandia, particularly in pulsed power research. This report provides detailed PFF specifications for accessing data without relying on legacy code.

  18. 46 CFR Sec. 3 - Specifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Specifications. Sec. 3 Section 3 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY PROCEDURE FOR ACCOMPLISHMENT OF VESSEL REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec....

  19. 46 CFR Sec. 3 - Specifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false Specifications. Sec. 3 Section 3 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY PROCEDURE FOR ACCOMPLISHMENT OF VESSEL REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec....

  20. 46 CFR Sec. 3 - Specifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false Specifications. Sec. 3 Section 3 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY PROCEDURE FOR ACCOMPLISHMENT OF VESSEL REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec....

  1. 46 CFR Sec. 3 - Specifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false Specifications. Sec. 3 Section 3 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY PROCEDURE FOR ACCOMPLISHMENT OF VESSEL REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec....

  2. 46 CFR Sec. 3 - Specifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 8 2012-10-01 2012-10-01 false Specifications. Sec. 3 Section 3 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY PROCEDURE FOR ACCOMPLISHMENT OF VESSEL REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec....

  3. Grade 3 Science Curriculum Specifications.

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Curriculum Branch.

    The specific content areas and objectives from which the Alberta, Canada, Grade 3 Science Achievement Test questions were derived are outlined in this bulletin. The document contains: (1) curriculum summary (providing a general listing of the process skills, psychomotor skills, attitudes, and subject matter covered at the grade 3 level); (2) a…

  4. Netware-Specific Network Security.

    ERIC Educational Resources Information Center

    Snyder, Robin M.

    This paper focuses on practical and cost-effective NetWare-specific approaches to information systems and computer security. A series of real world experiences is presented that illustrate fundamental information systems and security concepts. A NetWare network is a client-server network which uses a file server to share files while client…

  5. 76 FR 7482 - Operations Specifications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-10

    ... in common carriage (75 FR 25127). Specifically, the FAA proposed to clarify and standardize the rules.... The European Aviation Safety Agency (EASA) obtained competence from the European Parliament to... European Community (EC) in 2008. Regulation (EC) No 216/2008 provides competence to EASA to issue and...

  6. CONTRACT DOCUMENTS AND PERFORMANCE SPECIFICATIONS.

    ERIC Educational Resources Information Center

    First California Commission on School Construction Systems, Palo Alto.

    A SET OF EDUCATIONAL SPECIFICATION DRAFTED BY THE FIRST CALIFORNIA COMMISSION ON SCHOOL CONSTRUCTION SYSTEMS GIVES INFORMATION ON BIDDING PROCEDURES, A DESCRIPTION OF THE CURRENT CONSTRUCTION PROGRAM, PROCEDURES FOR SUBMITTING A PROPOSAL, DATA AND CONDITIONS RELATED TO THE DEVELOPMENT PHASE OF THE PROJECT, COMPONENT CONTRACTS, AND GENERAL…

  7. Reflight certification software design specifications

    NASA Technical Reports Server (NTRS)

    1984-01-01

    The PDSS/IMC Software Design Specification for the Payload Development Support System (PDSS)/Image Motion Compensator (IMC) is contained. The PDSS/IMC is to be used for checkout and verification of the IMC flight hardware and software by NASA/MSFC.

  8. Adaptive Assessments Using Open Specifications

    ERIC Educational Resources Information Center

    Leon, Hector Barbosa; Garcia-Penalvo, Francisco J.; Rodriguez-Conde, Maria Jose; Morales, Erla M.; de Pablos, Patricia Ordonez

    2012-01-01

    Evaluation is a key element in formal education processes; it must be constructed in a way that the item questions within help students understand by adapting them to the learning style as well. The focus of the present research work specifically in the convenience to adapt an associated multimedia material in each single question besides the…

  9. Category Specific Dictionary Learning for Attribute Specific Feature Selection.

    PubMed

    Wang, Wei; Yan, Yan; Winkler, Stefan; Sebe, Nicu

    2016-03-01

    Attributes, as mid-level features, have demonstrated great potential in visual recognition tasks due to their excellent propagation capability through different categories. However, existing attribute learning methods are prone to learning the correlated attributes. To discover the genuine attribute specific features, many feature selection methods have been proposed. However, these feature selection methods are implemented at the level of raw features that might be very noisy, and these methods usually fail to consider the structural information in the feature space. To address this issue, in this paper, we propose a label constrained dictionary learning approach combined with a multilayer filter. The feature selection is implemented at dictionary level, which can better preserve the structural information. The label constrained dictionary learning suppresses the intra-class noise by encouraging the sparse representations of intra-class samples to lie close to their center. A multilayer filter is developed to discover the representative and robust attribute specific bases. The attribute specific bases are only shared among the positive samples or the negative samples. The experiments on the challenging Animals with Attributes data set and the SUN attribute data set demonstrate the effectiveness of our proposed method.

  10. Isotope specific arbitrary material sorter

    SciTech Connect

    Barty, Christopher P.J.

    2015-12-08

    A laser-based mono-energetic gamma-ray source is used to provide a rapid and unique, isotope specific method for sorting materials. The objects to be sorted are passed on a conveyor in front of a MEGa-ray beam which has been tuned to the nuclear resonance fluorescence transition of the desired material. As the material containing the desired isotope traverses the beam, a reduction in the transmitted MEGa-ray beam occurs. Alternately, the laser-based mono-energetic gamma-ray source is used to provide non-destructive and non-intrusive, quantitative determination of the absolute amount of a specific isotope contained within pipe as part of a moving fluid or quasi-fluid material stream.

  11. Certifying Domain-Specific Policies

    NASA Technical Reports Server (NTRS)

    Lowry, Michael; Pressburger, Thomas; Rosu, Grigore; Koga, Dennis (Technical Monitor)

    2001-01-01

    Proof-checking code for compliance to safety policies potentially enables a product-oriented approach to certain aspects of software certification. To date, previous research has focused on generic, low-level programming-language properties such as memory type safety. In this paper we consider proof-checking higher-level domain -specific properties for compliance to safety policies. The paper first describes a framework related to abstract interpretation in which compliance to a class of certification policies can be efficiently calculated Membership equational logic is shown to provide a rich logic for carrying out such calculations, including partiality, for certification. The architecture for a domain-specific certifier is described, followed by an implemented case study. The case study considers consistency of abstract variable attributes in code that performs geometric calculations in Aerospace systems.

  12. Pattern specificity of contrast adaptation

    PubMed Central

    Anstis, Stuart

    2014-01-01

    Contrast adaptation is specific to precisely localised edges, so that adapting to a flickering photograph makes one less sensitive to that same photograph, but not to similar photographs. When two low-contrast photos, A and B, are transparently superimposed, then adapting to a flickering high-contrast B leaves no net afterimage, but it makes B disappear from the A+B picture, which now simply looks like A. PMID:25165518

  13. Host specificity of parasite manipulation

    PubMed Central

    2012-01-01

    Recently we presented how Camponotus ants in Thailand infected with the fungus Ophiocordyceps unilateralis are behaviorally manipulated into dying where the conditions are optimal for fungal development. Death incurred in a very narrow zone of space and here we compare this highly specific manipulation with a related system in Brazil. We show that the behavioral manipulation is less fine-tuned and discuss the potential explanations for this by examining differences in ant host and environmental characteristics. PMID:22808322

  14. Intron-Specific Neuropeptide Probes

    PubMed Central

    Gainer, Harold; Ponzio, Todd A.; Yue, Chunmei; Kawasaki, Makoto

    2016-01-01

    Measurements of changes in pre-mRNA levels by intron-specific probes are generally accepted as more closely reflecting changes in gene transcription rates than are measurements of mRNA levels by exonic probes. This is, in part, because the pre-mRNAs, which include the primary transcript and various splicing intermediates located in the nucleus (also referred to as heteronuclear RNAs, or hnRNAs), are processed rapidly (with half-lives <60 min) as compared to neuropeptide mRNAs, which are then transferred to the cytoplasm and which have much longer half-lives (often over days). In this chapter, we describe the use of exon-and intron-specific probes to evaluate oxytocin (OT) and vasopressin (VP) neuropeptide gene expression by analyses of their mRNAs and hnRNAs by quantitative in situ hybridization (qISH) and also by using specific PCR primers in quantitative, real-time PCR (qPCR) procedures. PMID:21922402

  15. Specific test and evaluation plan

    SciTech Connect

    Hays, W.H.

    1997-12-09

    The purpose of this Specific Test and Evaluation Plan (STEP) is to provide a detailed written plan for the systematic testing of modifications made to the 241-AN-A Valve Pit by the W-314 Project. The STEP develops the outline for test procedures that verify the system`s performance to the established Project design criteria. The STEP is a ``lower tier`` document based on the W-314 Test and Evaluation Plan (TEP) This STEP encompasses all testing activities required to demonstrate compliance to the project design criteria as it relates to the modifications of the AN-A valve pit. The Project Design Specifications (PDS) identify the specific testing activities required for the Project. Testing includes Validations and Verifications (e.g., Commercial Grade Item Dedication activities), Factory Acceptance Tests (FATs), installation tests and inspections, Construction Acceptance Tests (CATs), Acceptance Test Procedures (ATPs), Pre-Operational Test Procedures (POTPs), and Operational Test Procedures (OTPs). It should be noted that POTPs are not required for testing of the modifications to the 241-AN-A Valve Pit. The STEP will be utilized in conjunction with the TEP for verification and validation.

  16. Chromosome specific repetitive DNA sequences

    DOEpatents

    Moyzis, Robert K.; Meyne, Julianne

    1991-01-01

    A method is provided for determining specific nucleotide sequences useful in forming a probe which can identify specific chromosomes, preferably through in situ hybridization within the cell itself. In one embodiment, chromosome preferential nucleotide sequences are first determined from a library of recombinant DNA clones having families of repetitive sequences. Library clones are identified with a low homology with a sequence of repetitive DNA families to which the first clones respectively belong and variant sequences are then identified by selecting clones having a pattern of hybridization with genomic DNA dissimilar to the hybridization pattern shown by the respective families. In another embodiment, variant sequences are selected from a sequence of a known repetitive DNA family. The selected variant sequence is classified as chromosome specific, chromosome preferential, or chromosome nonspecific. Sequences which are classified as chromosome preferential are further sequenced and regions are identified having a low homology with other regions of the chromosome preferential sequence or with known sequences of other family me This invention is the result of a contract with the Department of Energy (Contract No. W-7405-ENG-36).

  17. Lack of specificity of commercially available antisera: better specifications needed.

    PubMed

    Pradidarcheep, Wisuit; Labruyère, Wil T; Dabhoiwala, Noshir F; Lamers, Wouter H

    2008-12-01

    The ideal antiserum for immunohistochemical (IHC) applications contains monospecific high-affinity antibodies with little nonspecific adherence to sections. Many commercially available antibodies are "affinity" purified, but it is unknown if they meet "hard" specificity criteria, such as absence of staining in tissues genetically deficient for the antigen or a staining pattern that is identical to that of an antibody raised against a different epitope on the same protein. Reviewers, therefore, often require additional characterization. Although the affinity-purified antibodies used in our study on the distribution of muscarinic receptors produced selective staining patterns on sections, few passed the preabsorption test, and none produced bands of the anticipated size on Western blots. More importantly, none showed a difference in staining pattern on sections or Western blots between wild-type and knockout mice. Because these antibodies were used in most studies published thus far, our findings cast doubts on the validity of the extant body of morphological knowledge of the whole family of muscarinic receptors. We formulate requirements that antibody-specification data sheets should meet and propose that journals for which IHC is a core technique facilitate consumer rating of antibodies. "Certified" antibodies could avoid fruitless and costly validation assays and should become the standard of commercial suppliers.

  18. Lack of specificity of commercially available antisera: better specifications needed.

    PubMed

    Pradidarcheep, Wisuit; Labruyère, Wil T; Dabhoiwala, Noshir F; Lamers, Wouter H

    2008-12-01

    The ideal antiserum for immunohistochemical (IHC) applications contains monospecific high-affinity antibodies with little nonspecific adherence to sections. Many commercially available antibodies are "affinity" purified, but it is unknown if they meet "hard" specificity criteria, such as absence of staining in tissues genetically deficient for the antigen or a staining pattern that is identical to that of an antibody raised against a different epitope on the same protein. Reviewers, therefore, often require additional characterization. Although the affinity-purified antibodies used in our study on the distribution of muscarinic receptors produced selective staining patterns on sections, few passed the preabsorption test, and none produced bands of the anticipated size on Western blots. More importantly, none showed a difference in staining pattern on sections or Western blots between wild-type and knockout mice. Because these antibodies were used in most studies published thus far, our findings cast doubts on the validity of the extant body of morphological knowledge of the whole family of muscarinic receptors. We formulate requirements that antibody-specification data sheets should meet and propose that journals for which IHC is a core technique facilitate consumer rating of antibodies. "Certified" antibodies could avoid fruitless and costly validation assays and should become the standard of commercial suppliers. PMID:18796405

  19. Central Solenoid Insert Technical Specification

    SciTech Connect

    Martovetsky, Nicolai N; Smirnov, Alexandre

    2011-09-01

    The US ITER Project Office (USIPO) is responsible for the ITER central solenoid (CS) contribution to the ITER project. The Central Solenoid Insert (CSI) project will allow ITER validation the appropriate lengths of the conductors to be used in the full-scale CS coils under relevant conditions. The ITER Program plans to build and test a CSI to verify the performance of the CS conductor. The CSI is a one-layer solenoid with an inner diameter of 1.48 m and a height of 4.45 m between electric terminal ends. The coil weight with the terminals is approximately 820 kg without insulation. The major goal of the CSI is to measure the temperature margin of the CS under the ITER direct current (DC) operating conditions, including determining sensitivity to load cycles. Performance of the joints, ramp rate sensitivity, and stability against thermal or electromagnetic disturbances, electrical insulation, losses, and instrumentation are addressed separately and therefore are not major goals in this project. However, losses and joint performance will be tested during the CSI testing campaign. The USIPO will build the CSI that will be tested at the Central Solenoid Model Coil (CSMC) Test Facility at the Japan Atomic Energy Agency (JAEA), Naka, Japan. The industrial vendors (the Suppliers) will report to the USIPO (the Company). All approvals to proceed will be issued by the Company, which in some cases, as specified in this document, will also require the approval of the ITER Organization. Responsibilities and obligations will be covered by respective contracts between the USIPO, called Company interchangeably, and the industrial Prime Contractors, called Suppliers. Different stages of work may be performed by more than one Prime Contractor, as described in this specification. Technical requirements of the contract between the Company and the Prime Contractor will be covered by the Fabrication Specifications developed by the Prime Contractor based on this document and approved by

  20. Logic programming and metadata specifications

    NASA Technical Reports Server (NTRS)

    Lopez, Antonio M., Jr.; Saacks, Marguerite E.

    1992-01-01

    Artificial intelligence (AI) ideas and techniques are critical to the development of intelligent information systems that will be used to collect, manipulate, and retrieve the vast amounts of space data produced by 'Missions to Planet Earth.' Natural language processing, inference, and expert systems are at the core of this space application of AI. This paper presents logic programming as an AI tool that can support inference (the ability to draw conclusions from a set of complicated and interrelated facts). It reports on the use of logic programming in the study of metadata specifications for a small problem domain of airborne sensors, and the dataset characteristics and pointers that are needed for data access.

  1. Flight Guidance System Requirements Specification

    NASA Technical Reports Server (NTRS)

    Miller, Steven P.; Tribble, Alan C.; Carlson, Timothy M.; Danielson, Eric J.

    2003-01-01

    This report describes a requirements specification written in the RSML-e language for the mode logic of a Flight Guidance System of a typical regional jet aircraft. This model was created as one of the first steps in a five-year project sponsored by the NASA Langley Research Center, Rockwell Collins Inc., and the Critical Systems Research Group of the University of Minnesota to develop new methods and tools to improve the safety of avionics designs. This model will be used to demonstrate the application of a variety of methods and techniques, including safety analysis of system and subsystem requirements, verification of key properties using theorem provers and model checkers, identification of potential sources mode confusion in system designs, partitioning of applications based on the criticality of system hazards, and autogeneration of avionics quality code. While this model is representative of the mode logic of a typical regional jet aircraft, it does not describe an actual or planned product. Several aspects of a full Flight Guidance System, such as recovery from failed sensors, have been omitted, and no claims are made regarding the accuracy or completeness of this specification.

  2. Cockpit display requirements and specifications

    NASA Astrophysics Data System (ADS)

    Hopper, Darrel G.

    1993-12-01

    Flight instrument design has begun to include a new electronic technology for the display head: active matrix liquid crystal display (AMLCD). This is a significant design transition and applies across the board to complete cockpit modernization programs, individual instrument replacement projects, and new systems. AMLCD-based instruments are expected to have a substantially higher mean time between failure compared to both electromechanical and CRT- based instruments. Thus, the new technology will pay for itself. Furthermore, AMLCDs are truly sunlight-readable whereas CRT displays are not; it is mission critical that a pilot be able to see an instrument with the sun shining directly in the eye or onto the display. AMLCDs can also provide larger display areas enabling formats which increase situational awareness. As this is a new technology for the military, an industrial base for militarized AMLCDs must be created based on present research capabilities. The requirements for AMLCDs in DOD programs have been analyzed. Projects to build infrastructure and capacity are described. Applications include not only cockpits, but also digital map/GPS integrated displays for tank commanders and field laptop computers. We have the opportunity with this new technology to establish a common critical item product function specification for sunlight-readable, color and grayscale capable, flat panel displays for military applications. the Wright Laboratory is leading the development of such functional specification for U.S. military aircraft.

  3. Age-specific divorce rates.

    PubMed

    Kunz, P R; England, J L

    1988-01-01

    This paper examines the various types of US divorce rates in 1970 and 1980 and concludes that the age-specific rate is most precise. Using data from the states' vital statistics reports and the 1980 census reports for states, the authors conclude that the teen and early 20s marriages are most at risk to divorce. Rates have increased from 1970 to 1980 with the most dramatic increases occurring in the 25-35 and 40-44 age groups. Study needs to be done to see what factors have led to such disproportionate increases in divorce rates in these age categories. Similarly, research is needed to understand why the 55 and over groups show no change of decline in rates between 1970 and 1980 in light of increases in other age groups. Contrary to general belief, however, divorce does not increase during the 'mid-life crisis' or ' after the children leave home.' PMID:12281968

  4. Specific test and evaluation plan

    SciTech Connect

    Hays, W.H.

    1998-03-20

    The purpose of this Specific Test and Evaluation Plan (STEP) is to provide a detailed written plan for the systematic testing of modifications made to the 241-AX-B Valve Pit by the W-314 Project. The STEP develops the outline for test procedures that verify the system`s performance to the established Project design criteria. The STEP is a lower tier document based on the W-314 Test and Evaluation Plan (TEP). Testing includes Validations and Verifications (e.g., Commercial Grade Item Dedication activities), Factory Acceptance Tests (FATs), installation tests and inspections, Construction Acceptance Tests (CATs), Acceptance Test Procedures (ATPs), Pre-Operational Test Procedures (POTPs), and Operational Test Procedures (OTPs). It should be noted that POTPs are not required for testing of the transfer line addition. The STEP will be utilized in conjunction with the TEP for verification and validation.

  5. Genetic specificity of face recognition.

    PubMed

    Shakeshaft, Nicholas G; Plomin, Robert

    2015-10-13

    Specific cognitive abilities in diverse domains are typically found to be highly heritable and substantially correlated with general cognitive ability (g), both phenotypically and genetically. Recent twin studies have found the ability to memorize and recognize faces to be an exception, being similarly heritable but phenotypically substantially uncorrelated both with g and with general object recognition. However, the genetic relationships between face recognition and other abilities (the extent to which they share a common genetic etiology) cannot be determined from phenotypic associations. In this, to our knowledge, first study of the genetic associations between face recognition and other domains, 2,000 18- and 19-year-old United Kingdom twins completed tests assessing their face recognition, object recognition, and general cognitive abilities. Results confirmed the substantial heritability of face recognition (61%), and multivariate genetic analyses found that most of this genetic influence is unique and not shared with other cognitive abilities.

  6. Engineering antibody affinity and specificity.

    PubMed

    Webster, D M; Roberts, S; Cheetham, J C; Griest, R; Rees, A R

    1988-01-01

    A combination of ab initio calculations, "knowledge-based prediction", molecular graphics and site-directed mutagenesis has enabled us to probe the molecular details of antibody:antigen recognition and binding and to alter the affinity and specificity of an antibody for its antigen. The significance of electrostatic hydrogen bonding, hydrophilic/hydrophobic patch matching and van der Waals interactions as well as CDR:CDR interactions are discussed in relation to the results of site-directed mutagenesis experiments on the anti-lysozyme antibody Gloop2. The ability to generate reconstructed antibodies, chimeric antibodies, catalytic antibodies and the use of modelled antibodies for the design of drugs is discussed. PMID:3209295

  7. Developmental Specification of Metabolic Circuitry

    PubMed Central

    Elson, Amanda E.T.; Simerly, Richard B.

    2015-01-01

    The hypothalamus contains a core circuitry that communicates with the brainstem and spinal cord to regulate energy balance. Because metabolic phenotype is influenced by environmental variables during perinatal development, it is important to understand how these neural pathways form in order to identify key signaling pathways that are responsible for metabolic programming. Recent progress in defining gene expression events that direct early patterning and cellular specification of the hypothalamus, as well as advances in our understanding of hormonal control of central neuroendocrine pathways, suggest several key regulatory nodes that may represent targets for metabolic programming of brain structure and function. This review focuses on components of central circuitry known to regulate various aspects of energy balance and summarizes what is known about their developmental neurobiology within the context of metabolic programming. PMID:26407637

  8. Molecular-specific urokinase antibodies

    NASA Technical Reports Server (NTRS)

    Atassi, M. Zouhair (Inventor); Morrison, Dennis R. (Inventor)

    2009-01-01

    Antibodies have been developed against the different molecular forms of urokinase using synthetic peptides as immunogens. The peptides were synthesized specifically to represent those regions of the urokinase molecules which are exposed in the three-dimensional configuration of the molecule and are uniquely homologous to urokinase. Antibodies are directed against the lysine 158-isoleucine 159 peptide bond which is cleaved during activation from the single-chain (ScuPA) form to the bioactive double chain (54 KDa and 33 KDa) forms of urokinase and against the lysine 135 lysine 136 bond that is cleaved in the process of removing the alpha-chain from the 54 KDa form to produce the 33 KDa form of urokinase. These antibodies enable the direct measurement of the different molecular forms of urokinase from small samples of conditioned medium harvested from cell cultures.

  9. DETERMINATION OF SPECIFIC NEUTRONIC REACTIVITY

    DOEpatents

    Dessauer, G.

    1960-05-10

    A method is given for production-line determination of the specific neutronic reactivity of such objects as individual nuclear fuel or neutron absorber elements and is notable for rapidity and apparatus simplicity. The object is incorporated in a slightly sub-critical chain fission reactive assembly having a discrete neutron source, thereby establishing a K/sub eff/ within the crucial range of 0.95 to 0.995. The range was found to afford, uniquely, flux- transient damped response in a niatter of seconds simultaneously with acceptable analytical sensitivity. The resulting neutron flux measured at a situs spaced from both object and source within the assembly serves as a calibrable indication of said reactivity.

  10. Specific Carbohydrate Diet: Does It Work?

    MedlinePlus

    ... Specific Carbohydrate Diet (SCD) Go Back The Specific Carbohydrate Diet (SCD) Email Print + Share There is no ... diet that has received attention is the Specific Carbohydrate Diet. This diet limits poorly digestible carbohydrates to ...

  11. Formal specification of human-computer interfaces

    NASA Technical Reports Server (NTRS)

    Auernheimer, Brent

    1990-01-01

    A high-level formal specification of a human computer interface is described. Previous work is reviewed and the ASLAN specification language is described. Top-level specifications written in ASLAN for a library and a multiwindow interface are discussed.

  12. 14 CFR 34.81 - Fuel specifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... EXHAUST EMISSION REQUIREMENTS FOR TURBINE ENGINE POWERED AIRPLANES Test Procedures for Engine Smoke Emissions (Aircraft Gas Turbine Engines) § 34.81 Fuel specifications. Fuel having specifications as...

  13. 14 CFR 34.81 - Fuel specifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... EXHAUST EMISSION REQUIREMENTS FOR TURBINE ENGINE POWERED AIRPLANES Test Procedures for Engine Smoke Emissions (Aircraft Gas Turbine Engines) § 34.81 Fuel specifications. Fuel having specifications as...

  14. Observations of Debris Impact on Buildings and Infrastructure after the 2011 Tohoku Tsunami

    NASA Astrophysics Data System (ADS)

    Cox, D.; Naito, C.; Yu, K.; Mizutani, N.; Tsujio, D.

    2011-12-01

    We present observations of the performance of structural systems (buildings, bridges, port infrastructure) after the 2011 Tohoku Tsunami. In particular, our observations focused on the hydraulic, hydrodynamic and impact demands. While it is likely that hydraulic and hydrodynamic demands resulted in considerable destruction, debris impact events provided significant contribution to some of the losses observed. Current knowledge on how to quantify the effects of impact demands from tsunami generated debris is limited. Methods provided by code sources including ASCE 7, AASHTO LRFD, and the Coastal Construction Manual result in order of magnitude differences in expected demands. This RAPID investigation examined the demands generated by debris in different coastal communities including the Sendai plain (Natori, Sendai Port) and the ria coast (Onagawa, Rikuzentakata, Kesennuma, Minamisanriku). Our investigation quantifies debris type, damage type, and debris flow characteristics. Observations indicate that the Tohoku event generated a spectrum of debris ranging from wood, vehicles, and shipping containers, to entire houses and ships. The structural system types observed included reinforced concrete buildings, steel moment frame buildings, wood frame houses. Damages to fuel storage containers were also a focus of this investigation. In general, our observations show that debris loads can add significantly to the overall loads, particularly when the debris size is large relative to the impacted structure. In addition. the occurrence of impact events was not necessarily associated with all types of debris, and some structural systems were more sensitive to a type of impact demand. For example, open systems such as pile supported buildings which offered little flow resistance were more susceptible to debris strikes than bluff sided buildings. This material is based upon work supported by the National Science Foundation under Grant No. CMMI-1138668. Any opinions, findings

  15. Species-specific optical lattices

    SciTech Connect

    LeBlanc, L. J.; Thywissen, J. H.

    2007-05-15

    We examine single-frequency optical schemes for species-selective trapping of ultracold alkali-metal atoms. Independently addressing the elements of a binary mixture enables the creation of an optical lattice for one atomic species with little or no effect on the other. We analyze a 'tune-in' scheme, using near-resonant detuning to create a strong potential for one specific element. A 'tune-out' scheme is also developed, in which the trapping wavelength is chosen to lie between two strong transitions of an alkali-metal atom such that the induced dipole moment is zero for that species but is nonzero for any other. We compare these schemes by examining the trap depths and heating rates associated with both. We find that the tune-in scheme is preferable for Li-Na, Li-K, and K-Na mixtures, while the tune-out scheme is preferable for Li-Cs, K-Rb, Rb-Cs, K-Cs, and {sup 39}K-{sup 40}K mixtures. Several applications of species-selective optical lattices are explored, including the creation of a lattice for a single species in the presence of a phononlike background, the tuning of relative effective mass, and the isothermal increase of phase-space density.

  16. Tumor specific cytotoxicity of glucosylceramide.

    PubMed

    Oku, Hirosuke; Wongtangtintharn, Sawitree; Iwasaki, Hironori; Inafuku, Masashi; Shimatani, Masayuki; Toda, Takayoshi

    2007-11-01

    To develop a new taxon of anti-cancer agent with lower side effect, this study described a tumor selective cytotoxicity of glucosylceramide extracted from malt feed of beer brewing waste. Interpretation of (13)C- and (1)H-NMR spectra identified the chemical structure of major component of glucosylceramide as 1-O-beta-D: -glucopyranosyl-2(2'-hydroxyeicosanoylamino)-4,11-octadecadiene-1,3-diol. Selective cytotoxicity was studied with three pairs of normal and cancer cells: liver, skin and lung. The glucosylceramide selectively lowered the relative viability of cancer cells. Of the pairs, the selectivity was most pronounced with the liver cells, and, for this reason, further experiment was conducted with this pair of normal (CS-HC) and cancer cells (HepG2) to get more insight into the selective toxicity. The glucosylceramide significantly increased the cell population at G(2)/M phase in HepG2 cells, and also increased the numbers of apoptotic (sub-G(0)/G(1)) cells, but to much lesser extent compared with the increase in G(2)/M phase. Treatment of HepG2 cells with this agent selectively disrupted the mitochondrial membrane integrity without activation of caspase pathway to induce apoptosis. These findings suggested that the glucosylceramide specifically suppressed the growth of cancer cells by inhibiting cell renewal capacity rather than induction of apoptosis. The underlying mechanism for the selectivity remains to be answered in the forthcoming study.

  17. Are specific emotions narrated differently?

    PubMed

    Habermas, Tilmann; Meier, Michaela; Mukhtar, Barbara

    2009-12-01

    Two studies test the assertion that anger, sadness, fear, pride, and happiness are typically narrated in different ways. Everyday events eliciting these 5 emotions were narrated by young women (Study 1) and 5- and 8-year-old girls (Study 2). Negative narratives were expected to engender more effort to process the event, be longer, more grammatically complex, more often have a complication section, and use more specific emotion labels than global evaluations. Narratives of Hogan's (2003) juncture emotions anger and fear were expected to focus more on action and to contain more core narrative sections of orientation, complication, and resolution than narratives of the outcome emotions sadness and happiness. Hypotheses were confirmed for adults except for syntactic complexity, whereas children showed only some of these differences. Hogan's theory that juncture emotions are restricted to the complication section was not confirmed. Finally, in adults, indirect speech was more frequent in anger narratives and internal monologue in fear narratives. It is concluded that different emotions should be studied in how they are narrated, and that narratives should be analyzed according to qualitatively different emotions. PMID:20001120

  18. Are specific emotions narrated differently?

    PubMed

    Habermas, Tilmann; Meier, Michaela; Mukhtar, Barbara

    2009-12-01

    Two studies test the assertion that anger, sadness, fear, pride, and happiness are typically narrated in different ways. Everyday events eliciting these 5 emotions were narrated by young women (Study 1) and 5- and 8-year-old girls (Study 2). Negative narratives were expected to engender more effort to process the event, be longer, more grammatically complex, more often have a complication section, and use more specific emotion labels than global evaluations. Narratives of Hogan's (2003) juncture emotions anger and fear were expected to focus more on action and to contain more core narrative sections of orientation, complication, and resolution than narratives of the outcome emotions sadness and happiness. Hypotheses were confirmed for adults except for syntactic complexity, whereas children showed only some of these differences. Hogan's theory that juncture emotions are restricted to the complication section was not confirmed. Finally, in adults, indirect speech was more frequent in anger narratives and internal monologue in fear narratives. It is concluded that different emotions should be studied in how they are narrated, and that narratives should be analyzed according to qualitatively different emotions.

  19. Specificity factors in cytoplasmic polyadenylation.

    PubMed

    Charlesworth, Amanda; Meijer, Hedda A; de Moor, Cornelia H

    2013-01-01

    Poly(A) tail elongation after export of an messenger RNA (mRNA) to the cytoplasm is called cytoplasmic polyadenylation. It was first discovered in oocytes and embryos, where it has roles in meiosis and development. In recent years, however, has been implicated in many other processes, including synaptic plasticity and mitosis. This review aims to introduce cytoplasmic polyadenylation with an emphasis on the factors and elements mediating this process for different mRNAs and in different animal species. We will discuss the RNA sequence elements mediating cytoplasmic polyadenylation in the 3' untranslated regions of mRNAs, including the CPE, MBE, TCS, eCPE, and C-CPE. In addition to describing the role of general polyadenylation factors, we discuss the specific RNA binding protein families associated with cytoplasmic polyadenylation elements, including CPEB (CPEB1, CPEB2, CPEB3, and CPEB4), Pumilio (PUM2), Musashi (MSI1, MSI2), zygote arrest (ZAR2), ELAV like proteins (ELAVL1, HuR), poly(C) binding proteins (PCBP2, αCP2, hnRNP-E2), and Bicaudal C (BICC1). Some emerging themes in cytoplasmic polyadenylation will be highlighted. To facilitate understanding for those working in different organisms and fields, particularly those who are analyzing high throughput data, HUGO gene nomenclature for the human orthologs is used throughout. Where human orthologs have not been clearly identified, reference is made to protein families identified in man.

  20. High specific activity silicon-32

    DOEpatents

    Phillips, Dennis R.; Brzezinski, Mark A.

    1996-01-01

    A process for preparation of silicon-32 is provided and includes contacting an irradiated potassium chloride target, including spallation products from a prior irradiation, with sufficient water, hydrochloric acid or potassium hydroxide to form a solution, filtering the solution, adjusting pH of the solution to from about 5.5 to about 7.5, admixing sufficient molybdate-reagent to the solution to adjust the pH of the solution to about 1.5 and to form a silicon-molybdate complex, contacting the solution including the silicon-molybdate complex with a dextran-based material, washing the dextran-based material to remove residual contaminants such as sodium-22, separating the silicon-molybdate complex from the dextran-based material as another solution, adding sufficient hydrochloric acid and hydrogen peroxide to the solution to prevent reformation of the silicon-molybdate complex and to yield an oxidization state of the molybdate adapted for subsequent separation by an anion exchange material, contacting the solution with an anion exchange material whereby the molybdate is retained by the anion exchange material and the silicon remains in solution, and optionally adding sufficient alkali metal hydroxide to adjust the pH of the solution to about 12 to 13. Additionally, a high specific activity silicon-32 product having a high purity is provided.

  1. High specific activity silicon-32

    DOEpatents

    Phillips, D.R.; Brzezinski, M.A.

    1996-06-11

    A process for preparation of silicon-32 is provided and includes contacting an irradiated potassium chloride target, including spallation products from a prior irradiation, with sufficient water, hydrochloric acid or potassium hydroxide to form a solution, filtering the solution, adjusting pH of the solution from about 5.5 to about 7.5, admixing sufficient molybdate-reagent to the solution to adjust the pH of the solution to about 1.5 and to form a silicon-molybdate complex, contacting the solution including the silicon-molybdate complex with a dextran-based material, washing the dextran-based material to remove residual contaminants such as sodium-22, separating the silicon-molybdate complex from the dextran-based material as another solution, adding sufficient hydrochloric acid and hydrogen peroxide to the solution to prevent reformation of the silicon-molybdate complex and to yield an oxidation state of the molybdate adapted for subsequent separation by an anion exchange material, contacting the solution with an anion exchange material whereby the molybdate is retained by the anion exchange material and the silicon remains in solution, and optionally adding sufficient alkali metal hydroxide to adjust the pH of the solution to about 12 to 13. Additionally, a high specific activity silicon-32 product having a high purity is provided.

  2. Nanomechanics for specific biological detection

    NASA Astrophysics Data System (ADS)

    Alvarez, Mar; Carrascosa, Laura G.; Tamayo, Javier; Calle, Ana; Lechuga, Laura M.

    2003-04-01

    Nanomechanical biosensors have emerged as a promising platform for specific biological. Among the advantages are direct detection without need of labelling with fluorescent or radioactive molecules, very high sensitivity, reduced sensor area, and suitability for integration using silicon technology. Here we have studied the immobilization of oligonucleotide monolayers by monitoring the microcantilever bending. Oligonucleotides were derivatized with thiol molecules for self-assembly on the gold-coated side of a microcantilever. The geometry of the binding and the surface density were studied by mixing derivatized oligonucleotides with spacer self-assembled monolayers and by controlling the oligonucleotide functional group form. These results are compared with fluoresencent and chemiluminescence techniques. Furthermore, we present the first results of direct pesticide detection with microcantilever-based biosensors. Herbicide DDT was detected by performing competitive assays, in which the cantilever was coated with a synthetic DDT hapten, and it was exposured to different rations between the monoclonal antibody and the DDT. A new technique is presented for the detection of the nanomechanical response for biosensing applications, in which the resonant frequency is measured with about two orders of magnitude higher sensitivity. The low quality factor of the microcantilever in liquid is increased up by using an active feedback control, in which the cantilever oscillation is amplified and delayed and it is used as a driving force. The technique has been applied for the detection of ethanol, proteins, and pathogens.

  3. 40 CFR 87.81 - Fuel specifications.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) Definitions. Test Procedures for Engine Smoke Emissions (Aircraft Gas Turbine Engines) § 87.81 Fuel specifications. Fuel having specifications as provided in § 87.61 shall be used in smoke emission testing....

  4. Model Commissioning Plan and Guide Specifications

    SciTech Connect

    1997-03-01

    The objectives of Model Commissioning Plan and Guide Specifications are to ensure that the design team applies commissioning concepts to the design and prepares commissioning specifications and a commission plan for inclusion in the bid construction documents.

  5. 10 CFR 9.95 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Specific exemptions. 9.95 Section 9.95 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS Privacy Act Regulations Exemptions § 9.95 Specific exemptions....gov....

  6. 10 CFR 9.95 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Specific exemptions. 9.95 Section 9.95 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS Privacy Act Regulations Exemptions § 9.95 Specific exemptions....gov....

  7. 46 CFR 174.030 - Specific applicability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PERTAINING TO SPECIFIC VESSEL TYPES Special Rules Pertaining to Mobile Offshore Drilling Units § 174.030 Specific applicability. Each mobile offshore drilling unit (MODU) inspected under Subchapter IA of...

  8. 46 CFR 174.030 - Specific applicability.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... PERTAINING TO SPECIFIC VESSEL TYPES Special Rules Pertaining to Mobile Offshore Drilling Units § 174.030 Specific applicability. Each mobile offshore drilling unit (MODU) inspected under Subchapter IA of...

  9. 21 CFR 660.44 - Specificity.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Hepatitis B Surface Antigen § 660.44 Specificity. Each filling of the product shall be specific for Hepatitis B Surface Antigen as determined...

  10. 21 CFR 660.5 - Specificity.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Antibody to Hepatitis B Surface Antigen § 660.5 Specificity. Each filling of the product shall be specific for antibody to hepatitis B surface antigen,...

  11. 21 CFR 660.5 - Specificity.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Antibody to Hepatitis B Surface Antigen § 660.5 Specificity. Each filling of the product shall be specific for antibody to hepatitis B surface antigen,...

  12. 21 CFR 660.44 - Specificity.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Hepatitis B Surface Antigen § 660.44 Specificity. Each filling of the product shall be specific for Hepatitis B Surface Antigen as determined...

  13. 21 CFR 660.5 - Specificity.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Antibody to Hepatitis B Surface Antigen § 660.5 Specificity. Each filling of the product shall be specific for antibody to hepatitis B surface antigen,...

  14. 21 CFR 660.5 - Specificity.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Antibody to Hepatitis B Surface Antigen § 660.5 Specificity. Each filling of the product shall be specific for antibody to hepatitis B surface antigen,...

  15. 21 CFR 660.44 - Specificity.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Hepatitis B Surface Antigen § 660.44 Specificity. Each filling of the product shall be specific for Hepatitis B Surface Antigen as determined...

  16. 21 CFR 660.44 - Specificity.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Hepatitis B Surface Antigen § 660.44 Specificity. Each filling of the product shall be specific for Hepatitis B Surface Antigen as determined...

  17. 21 CFR 660.5 - Specificity.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Antibody to Hepatitis B Surface Antigen § 660.5 Specificity. Each filling of the product shall be specific for antibody to hepatitis B surface antigen,...

  18. 21 CFR 660.44 - Specificity.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Hepatitis B Surface Antigen § 660.44 Specificity. Each filling of the product shall be specific for Hepatitis B Surface Antigen as determined...

  19. Domain and Specification Models for Software Engineering

    NASA Technical Reports Server (NTRS)

    Iscoe, Neil; Liu, Zheng-Yang; Feng, Guohui

    1992-01-01

    This paper discusses our approach to representing application domain knowledge for specific software engineering tasks. Application domain knowledge is embodied in a domain model. Domain models are used to assist in the creation of specification models. Although many different specification models can be created from any particular domain model, each specification model is consistent and correct with respect to the domain model. One aspect of the system-hierarchical organization is described in detail.

  20. Methods for chromosome-specific staining

    DOEpatents

    Gray, Joe W.; Pinkel, Daniel

    1995-01-01

    Methods and compositions for chromosome-specific staining are provided. Compositions comprise heterogenous mixtures of labeled nucleic acid fragments having substantially complementary base sequences to unique sequence regions of the chromosomal DNA for which their associated staining reagent is specific. Methods include methods for making the chromosome-specific staining compositions of the invention, and methods for applying the staining compositions to chromosomes.

  1. 37 CFR 1.125 - Substitute specification.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... substitute specification includes no new matter. (c) A substitute specification submitted under this section must be submitted with markings showing all the changes relative to the immediate prior version of the specification of record. The text of any added subject matter must be shown by underlining the added text....

  2. 37 CFR 1.125 - Substitute specification.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... substitute specification includes no new matter. (c) A substitute specification submitted under this section must be submitted with markings showing all the changes relative to the immediate prior version of the specification of record. The text of any added subject matter must be shown by underlining the added text....

  3. Information Concerning Preparation of Specifications for Carpeting.

    ERIC Educational Resources Information Center

    Gilliland, John W.

    This paper argues for detailed, written carpeting specifications to assure that schools obtain quality products at competitive prices. The advantages of and specifications for school carpeting are given. A sample written specification contains items on: scope, general features, materials, acoustic characteristics, identification and acoustic…

  4. 50 CFR 648.260 - Specifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Atlantic Deep-Sea Red Crab FMP objectives and other FMP provisions. (b) Development of specifications. In..., DEPARTMENT OF COMMERCE FISHERIES OF THE NORTHEASTERN UNITED STATES Management Measures for the Atlantic Deep-Sea Red Crab Fishery § 648.260 Specifications. (a) Process for setting specifications. The...

  5. Programming Bacteriophages by Swapping Their Specificity Determinants.

    PubMed

    Goren, Moran G; Yosef, Ido; Qimron, Udi

    2015-12-01

    Bacteriophages, bacteria's natural enemies, may serve as potent antibacterial agents. Their specificity for certain bacterial sub-species limits their effectiveness, but allows selective targeting of bacteria. Lu and colleagues present a platform for such targeting through alteration of bacteriophages' host specificity by swapping specificity domains in their host-recognition ligand.

  6. Domain Specificity and Variability in Cognitive Development.

    ERIC Educational Resources Information Center

    Gelman, Rochel

    2000-01-01

    Maintains that there are core-specific and non-core-specific domains of knowledge, but that only the core-specific domains benefit from innate skeletal structures. Asserts that core skeletal domains are universally shared, even though their particular foci may vary. Emphasizes that individuals vary in terms of the noncore domains they acquire.…

  7. Specific cooling capacity of liquid nitrogen

    NASA Technical Reports Server (NTRS)

    Kilgore, R. A.; Adcock, J. B.

    1977-01-01

    The assumed cooling process and the method used to calculate the specific cooling capacity of liquid nitrogen are described, and the simple equation fitted to the calculated specific cooling capacity data, together with the graphical form calculated values of the specific cooling capacity of nitrogen for stagnation temperatures from saturation to 350 K and stagnation pressures from 1 to 10 atmospheres, are given.

  8. 14 CFR 34.81 - Fuel specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Emissions (Aircraft Gas Turbine Engines) § 34.81 Fuel specifications. Fuel having specifications as provided... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Fuel specifications. 34.81 Section 34.81 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT FUEL VENTING...

  9. 40 CFR 87.81 - Fuel specifications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) CONTROL OF AIR POLLUTION FROM AIRCRAFT AND AIRCRAFT ENGINES Test Procedures for Engine Smoke Emissions (Aircraft Gas Turbine Engines) § 87.81 Fuel specifications. Fuel having specifications as provided in § 87... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Fuel specifications. 87.81 Section...

  10. 40 CFR 86.1413 - Fuel specifications.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 20 2012-07-01 2012-07-01 false Fuel specifications. 86.1413 Section... Trucks; Certification Short Test Procedures § 86.1413 Fuel specifications. (a) The test fuel to be used... octane specification of the fuels does not apply. For all gasoline-fueled Otto-cycle light-duty...

  11. 40 CFR 86.1413 - Fuel specifications.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 20 2013-07-01 2013-07-01 false Fuel specifications. 86.1413 Section... Trucks; Certification Short Test Procedures § 86.1413 Fuel specifications. (a) The test fuel to be used... octane specification of the fuels does not apply. For all gasoline-fueled Otto-cycle light-duty...

  12. 40 CFR 87.81 - Fuel specifications.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 20 2011-07-01 2011-07-01 false Fuel specifications. 87.81 Section 87.81 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... (Aircraft Gas Turbine Engines) § 87.81 Fuel specifications. Fuel having specifications as provided in §...

  13. 40 CFR 86.1413 - Fuel specifications.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 19 2011-07-01 2011-07-01 false Fuel specifications. 86.1413 Section... Trucks; Certification Short Test Procedures § 86.1413 Fuel specifications. (a) The test fuel to be used... octane specification of the fuels does not apply. For all gasoline-fueled Otto-cycle light-duty...

  14. 40 CFR 86.1413 - Fuel specifications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 19 2010-07-01 2010-07-01 false Fuel specifications. 86.1413 Section... Trucks; Certification Short Test Procedures § 86.1413 Fuel specifications. (a) The test fuel to be used... octane specification of the fuels does not apply. For all gasoline-fueled Otto-cycle light-duty...

  15. Requirements Specification Language (RSL) and supporting tools

    NASA Technical Reports Server (NTRS)

    Frincke, Deborah; Wolber, Dave; Fisher, Gene; Cohen, Gerald C.

    1992-01-01

    This document describes a general purpose Requirement Specification Language (RSL). RSL is a hybrid of features found in several popular requirement specification languages. The purpose of RSL is to describe precisely the external structure of a system comprised of hardware, software, and human processing elements. To overcome the deficiencies of informal specification languages, RSL includes facilities for mathematical specification. Two RSL interface tools are described. The Browser view contains a complete document with all details of the objects and operations. The Dataflow view is a specialized, operation-centered depiction of a specification that shows how specified operations relate in terms of inputs and outputs.

  16. Methods for chromosome-specific staining

    DOEpatents

    Gray, J.W.; Pinkel, D.

    1995-09-05

    Methods and compositions for chromosome-specific staining are provided. Compositions comprise heterogeneous mixtures of labeled nucleic acid fragments having substantially complementary base sequences to unique sequence regions of the chromosomal DNA for which their associated staining reagent is specific. Methods include ways for making the chromosome-specific staining compositions of the invention, and methods for applying the staining compositions to chromosomes. 3 figs.

  17. 77 FR 15399 - Model Safety Evaluation for Plant-Specific Adoption of Technical Specifications Task Force...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-15

    ... (76 FR 73737), is available under ADAMS Accession No. ML120200484. NRC's PDR: You may examine and... COMMISSION Model Safety Evaluation for Plant-Specific Adoption of Technical Specifications Task Force...-specific adoption of Technical Specifications (TS) Task Force (TSTF) Traveler TSTF-505, Revision...

  18. User Interface Technology for Formal Specification Development

    NASA Technical Reports Server (NTRS)

    Lowry, Michael; Philpot, Andrew; Pressburger, Thomas; Underwood, Ian; Lum, Henry, Jr. (Technical Monitor)

    1994-01-01

    Formal specification development and modification are an essential component of the knowledge-based software life cycle. User interface technology is needed to empower end-users to create their own formal specifications. This paper describes the advanced user interface for AMPHION1 a knowledge-based software engineering system that targets scientific subroutine libraries. AMPHION is a generic, domain-independent architecture that is specialized to an application domain through a declarative domain theory. Formal specification development and reuse is made accessible to end-users through an intuitive graphical interface that provides semantic guidance in creating diagrams denoting formal specifications in an application domain. The diagrams also serve to document the specifications. Automatic deductive program synthesis ensures that end-user specifications are correctly implemented. The tables that drive AMPHION's user interface are automatically compiled from a domain theory; portions of the interface can be customized by the end-user. The user interface facilitates formal specification development by hiding syntactic details, such as logical notation. It also turns some of the barriers for end-user specification development associated with strongly typed formal languages into active sources of guidance, without restricting advanced users. The interface is especially suited for specification modification. AMPHION has been applied to the domain of solar system kinematics through the development of a declarative domain theory. Testing over six months with planetary scientists indicates that AMPHION's interactive specification acquisition paradigm enables users to develop, modify, and reuse specifications at least an order of magnitude more rapidly than manual program development.

  19. 10 CFR 76.23 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Specific exemptions. 76.23 Section 76.23 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS General Provisions § 76.23 Specific exemptions. The Commission may, upon its own initiative or upon application of the...

  20. 10 CFR 76.23 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Specific exemptions. 76.23 Section 76.23 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS General Provisions § 76.23 Specific exemptions. The Commission may, upon its own initiative or upon application of the...

  1. 10 CFR 76.23 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Specific exemptions. 76.23 Section 76.23 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS General Provisions § 76.23 Specific exemptions. The Commission may, upon its own initiative or upon application of the...

  2. 10 CFR 76.23 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Specific exemptions. 76.23 Section 76.23 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS General Provisions § 76.23 Specific exemptions. The Commission may, upon its own initiative or upon application of the...

  3. 10 CFR 76.23 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Specific exemptions. 76.23 Section 76.23 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS General Provisions § 76.23 Specific exemptions. The Commission may, upon its own initiative or upon application of the...

  4. 16 CFR 1210.15 - Specifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Specifications. 1210.15 Section 1210.15 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR CIGARETTE LIGHTERS Certification Requirements § 1210.15 Specifications. (a)...

  5. 16 CFR 1210.15 - Specifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Specifications. 1210.15 Section 1210.15 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR CIGARETTE LIGHTERS Certification Requirements § 1210.15 Specifications. (a)...

  6. 16 CFR 1210.15 - Specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Specifications. 1210.15 Section 1210.15 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR CIGARETTE LIGHTERS Certification Requirements § 1210.15 Specifications. (a)...

  7. General specifications covering requirements of aeronautic instruments

    NASA Technical Reports Server (NTRS)

    1917-01-01

    Report includes specifications for the use and production of instruments used in the navigation and operation of aircraft. Specifications are included for the following instruments: barometer or altimeter, compass, air speed meter, inclinometer, drift meter, tachometer, oil gauge, oil pressure gauge, gasoline gauge, gasoline flow indicator, distance indicator, barograph, angle of attack indicator, radiator temperature indicator, gasoline feed system pressure indicator, sextant, airplane director.

  8. 50 CFR 648.122 - Scup specifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Scup Fishery § 648.122 Scup specifications. (a) Commercial quota, recreational landing limits, research... conjunction with each ACL and ACT, a sector specific research set-aside, estimates of sector-related discards... to be considered by the Scup Monitoring Committee are as follows: (1) Research quota set from a...

  9. 50 CFR 648.122 - Scup specifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Scup Fishery § 648.122 Scup specifications. (a) Commercial quota, recreational landing limits, research... conjunction with each ACL and ACT, a sector specific research set-aside, estimates of sector-related discards... to be considered by the Scup Monitoring Committee are as follows: (1) Research quota set from a...

  10. Specificity of a Maximal Step Exercise Test

    ERIC Educational Resources Information Center

    Darby, Lynn A.; Marsh, Jennifer L.; Shewokis, Patricia A.; Pohlman, Roberta L.

    2007-01-01

    To adhere to the principle of "exercise specificity" exercise testing should be completed using the same physical activity that is performed during exercise training. The present study was designed to assess whether aerobic step exercisers have a greater maximal oxygen consumption (max VO sub 2) when tested using an activity specific, maximal step…

  11. Formalisms for user interface specification and design

    NASA Technical Reports Server (NTRS)

    Auernheimer, Brent J.

    1989-01-01

    The application of formal methods to the specification and design of human-computer interfaces is described. A broad outline of human-computer interface problems, a description of the field of cognitive engineering and two relevant research results, the appropriateness of formal specification techniques, and potential NASA application areas are described.

  12. Summary of beryllium specifications, current and historical

    SciTech Connect

    Abeln, S.P.; Kyed, P.

    1990-12-28

    This report summarizes beryllium properties included in producer, Department of Energy, and government specifications. The specifications are divided into two major categories: current and historical. Within each category the data are arranged primarily according to increasing purity and secondarily by increasing tensile properties. Qualitative comments on formability and weldability are included. Also, short summaries of powder production and consolidation techniques are provided.

  13. 14 CFR 91.1015 - Management specifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Management specifications. 91.1015 Section... Operations Program Management § 91.1015 Management specifications. (a) Each person conducting operations under this subpart or furnishing fractional ownership program management services to fractional...

  14. 14 CFR 91.1015 - Management specifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Management specifications. 91.1015 Section... Operations Program Management § 91.1015 Management specifications. (a) Each person conducting operations under this subpart or furnishing fractional ownership program management services to fractional...

  15. 14 CFR 91.1015 - Management specifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Management specifications. 91.1015 Section... Operations Program Management § 91.1015 Management specifications. (a) Each person conducting operations under this subpart or furnishing fractional ownership program management services to fractional...

  16. Global and Specific Ratings: Are They Related?

    ERIC Educational Resources Information Center

    Goodwin, Stephanie S.; Raths, James

    The purpose of this study was to determine if making specific changes in teaching, changes that were validated by experts, would change the overall student ratings of instructors. Thirty graduate teaching assistants who participated in a workshop on improving lecturing skills significantly improved their scores on specific lecturing behaviors that…

  17. 10 CFR 55.11 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Specific exemptions. 55.11 Section 55.11 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES Exemptions § 55.11 Specific exemptions. The Commission may, upon application by an interested person, or upon its own initiative, grant such exemptions...

  18. 10 CFR 55.11 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Specific exemptions. 55.11 Section 55.11 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES Exemptions § 55.11 Specific exemptions. The Commission may, upon application by an interested person, or upon its own initiative, grant such exemptions...

  19. 14 CFR 91.1015 - Management specifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Management specifications. 91.1015 Section... Operations Program Management § 91.1015 Management specifications. (a) Each person conducting operations under this subpart or furnishing fractional ownership program management services to fractional...

  20. 50 CFR 648.260 - Specifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...-Sea Red Crab Fishery § 648.260 Specifications. (a) Annual review and specifications process. The Council, the Red Crab Plan Development Team (PDT), and the Red Crab Advisory Panel shall monitor the status of the red crab fishery and resource. (1) The Red Crab PDT shall meet at least once...

  1. 50 CFR 648.260 - Specifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...-Sea Red Crab Fishery § 648.260 Specifications. (a) Annual review and specifications process. The Council, the Red Crab Plan Development Team (PDT), and the Red Crab Advisory Panel shall monitor the status of the red crab fishery and resource. (1) The Red Crab PDT shall meet at least once...

  2. 50 CFR 648.260 - Specifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...-Sea Red Crab Fishery § 648.260 Specifications. (a) Annual review and specifications process. The Council, the Red Crab Plan Development Team (PDT), and the Red Crab Advisory Panel shall monitor the status of the red crab fishery and resource. (1) The Red Crab PDT shall meet at least once...

  3. 50 CFR 648.260 - Specifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...-Sea Red Crab Fishery § 648.260 Specifications. (a) Annual review and specifications process. The Council, the Red Crab Plan Development Team (PDT), and the Red Crab Advisory Panel shall monitor the status of the red crab fishery and resource. (1) The Red Crab PDT shall meet at least once...

  4. Role of interleukin 10 in specific immunotherapy.

    PubMed Central

    Akdis, C A; Blesken, T; Akdis, M; Wüthrich, B; Blaser, K

    1998-01-01

    The induction of allergen-specific anergy in peripheral T cells represents a key step in specific immunotherapy (SIT). Here we demonstrate that the anergic state results from increased IL-10 production. In bee venom (BV)-SIT the specific proliferative and cytokine responses against the main allergen, the phospholipase A2 (PLA), and T cell epitope-containing PLA peptides were significantly suppressed after 7 d of treatment. Simultaneously, the production of IL-10 increased during BV-SIT. After 28 d of BV-SIT the anergic state was established. Intracytoplasmic cytokine staining of PBMC combined with surface marker detection revealed that IL-10 was produced initially by activated CD4(+)CD25(+), allergen-specific T cells, and followed by B cells and monocytes. Neutralization of IL-10 in PBMC fully reconstituted the specific proliferative and cytokine responses. A similar state of IL-10-associated T cell anergy, as induced in BV-SIT, was found in hyperimmune individuals who recently had received multiple bee stings. The addition of IL-10 to soluble CD40 ligand IL-4-stimulated PBMC or purified B cells inhibited the PLA-specific and total IgE and enhanced the IgG4 formation. Accordingly, increased IL-10 production by SIT causes specific anergy in peripheral T cells, and regulates specific IgE and IgG4 production toward normal IgG4-related immunity. PMID:9649562

  5. 49 CFR 451.23 - Plate specifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 6 2013-10-01 2013-10-01 false Plate specifications. 451.23 Section 451.23... SECURITY SAFETY APPROVAL OF CARGO CONTAINERS TESTING AND APPROVAL OF CONTAINERS Safety Approval Plate § 451.23 Plate specifications. (a) The safety approval plate must be of the size and in the...

  6. 49 CFR 451.23 - Plate specifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 6 2012-10-01 2012-10-01 false Plate specifications. 451.23 Section 451.23... SECURITY SAFETY APPROVAL OF CARGO CONTAINERS TESTING AND APPROVAL OF CONTAINERS Safety Approval Plate § 451.23 Plate specifications. (a) The safety approval plate must be of the size and in the...

  7. 40 CFR 35.936-13 - Specifications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Specifications. 35.936-13 Section 35.936-13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE... test or demonstrate a specific thing or to provide for necessary interchangeability of parts...

  8. 324 and 327 Facilities Environmental Effluent Specifications

    SciTech Connect

    JOHNSON, D.L.

    1999-08-30

    These effluent specifications address requirements for the 324/321 Facilities, which are undergoing stabilization activities. Effluent specifications are imposed to protect personnel, the environment and the public, by ensuring adequate implementation and compliance with federal and state regulatory requirements and Hanford programs.

  9. Plutonium Immobilization Can Loading Preliminary Specifications

    SciTech Connect

    Kriikku, E.

    1998-11-25

    This report discusses the Plutonium Immobilization can loading preliminary equipment specifications and includes a process block diagram, process description, equipment list, preliminary equipment specifications, plan and elevation sketches, and some commercial catalogs. This report identifies loading pucks into cans and backfilling cans with helium as the top priority can loading development areas.

  10. 10 CFR 63.43 - License specification.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false License specification. 63.43 Section 63.43 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses License Issuance and Amendment § 63.43 License specification. (a) A...

  11. 10 CFR 63.43 - License specification.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false License specification. 63.43 Section 63.43 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses License Issuance and Amendment § 63.43 License specification. (a) A...

  12. 10 CFR 63.43 - License specification.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false License specification. 63.43 Section 63.43 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses License Issuance and Amendment § 63.43 License specification. (a) A...

  13. 10 CFR 63.43 - License specification.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false License specification. 63.43 Section 63.43 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses License Issuance and Amendment § 63.43 License specification. (a) A...

  14. 10 CFR 63.43 - License specification.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false License specification. 63.43 Section 63.43 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses License Issuance and Amendment § 63.43 License specification. (a) A...

  15. 12 CFR 347.119 - Specific consent.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 5 2012-01-01 2012-01-01 false Specific consent. 347.119 Section 347.119 Banks... INTERNATIONAL BANKING § 347.119 Specific consent. General consent and expedited processing under this subpart do... activity that can be engaged in by foreign branches, which are not authorized under §§ 347.117 or...

  16. 12 CFR 347.119 - Specific consent.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 5 2014-01-01 2014-01-01 false Specific consent. 347.119 Section 347.119 Banks... INTERNATIONAL BANKING § 347.119 Specific consent. General consent and expedited processing under this subpart do... activity that can be engaged in by foreign branches, which are not authorized under §§ 347.117 or...

  17. 12 CFR 347.119 - Specific consent.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 5 2013-01-01 2013-01-01 false Specific consent. 347.119 Section 347.119 Banks... INTERNATIONAL BANKING § 347.119 Specific consent. General consent and expedited processing under this subpart do... activity that can be engaged in by foreign branches, which are not authorized under §§ 347.117 or...

  18. 48 CFR 8.712 - Specification changes.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Specification changes. 8... Are Blind or Severely Disabled 8.712 Specification changes. (a) The contracting activity shall notify the AbilityOne participating nonprofit agency and appropriate central nonprofit agency of any...

  19. 48 CFR 408.712 - Specification changes.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Specification changes. 408.712 Section 408.712 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE COMPETITION AND... People Who Are Blind or Severely Disabled 408.712 Specification changes. Prior to providing...

  20. 48 CFR 8.712 - Specification changes.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Specification changes. 8... Are Blind or Severely Disabled 8.712 Specification changes. (a) The contracting activity shall notify the AbilityOne participating nonprofit agency and appropriate central nonprofit agency of any...

  1. 48 CFR 408.712 - Specification changes.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Specification changes. 408.712 Section 408.712 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE COMPETITION AND... People Who Are Blind or Severely Disabled 408.712 Specification changes. Prior to providing...

  2. 43 CFR 3861.2 - Surveys: Specific.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Surveys: Specific. 3861.2 Section 3861.2..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL PATENT APPLICATIONS Surveys and Plats § 3861.2 Surveys: Specific....

  3. 43 CFR 3861.2 - Surveys: Specific.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Surveys: Specific. 3861.2 Section 3861.2..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL PATENT APPLICATIONS Surveys and Plats § 3861.2 Surveys: Specific....

  4. 43 CFR 3861.2 - Surveys: Specific.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Surveys: Specific. 3861.2 Section 3861.2..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL PATENT APPLICATIONS Surveys and Plats § 3861.2 Surveys: Specific....

  5. 43 CFR 3861.2 - Surveys: Specific.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Surveys: Specific. 3861.2 Section 3861.2..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL PATENT APPLICATIONS Surveys and Plats § 3861.2 Surveys: Specific....

  6. 14 CFR 398.3 - Specific airports.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Specific airports. 398.3 Section 398.3... STATEMENTS GUIDELINES FOR INDIVIDUAL DETERMINATIONS OF BASIC ESSENTIAL AIR SERVICE § 398.3 Specific airports. (a) At an eligible place, essential air service may be specified as service to a particular...

  7. VOSpace specification Version 2.0

    NASA Astrophysics Data System (ADS)

    Graham, Matthew; Morris, Dave; Rixon, Guy; Dowler, Pat; Schaaff, Andre; Tody, Doug; Graham, Matthew

    2013-03-01

    VOSpace is the IVOA interface to distributed storage. This specification presents the first RESTful version of the interface, which is functionally equivalent to the SOAP-based VOSpace 1.1 specification. Note that all prior VOSpace clients will not work with this new version of the interface.

  8. 14 CFR 91.1015 - Management specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Management specifications. 91.1015 Section... Operations Program Management § 91.1015 Management specifications. (a) Each person conducting operations under this subpart or furnishing fractional ownership program management services to fractional...

  9. 10 CFR 26.9 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Specific exemptions. 26.9 Section 26.9 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.9 Specific exemptions. Upon application of any interested person or on its own initiative, the Commission may grant such exemptions...

  10. Identifying Specific Comprehension Deficits in Children

    ERIC Educational Resources Information Center

    Gifford, Diane Baty

    2013-01-01

    Research has shown that educators may be missing an under-identified population of approximately 10 percent of typically developing children, who have fluent, age-appropriate decoding and word recognition skills, yet have specific difficulties with other higher-level text processing factors. These children are said to have specific comprehension…

  11. Motorcycle Education Curriculum Specifications. Final Report.

    ERIC Educational Resources Information Center

    McKnight, A. James; And Others

    This report contains specifications for a motorcycle safety education curriculum designed to reduce the incidence and severity of motorcycle accidents. The specifications prescribe objectives, prerequisites, methods, materials, equipment, facilities, and proficiency measures for six units of instruction: (1) basic riding skills, (2) street riding…

  12. 50 CFR 648.165 - Framework specifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Framework specifications. 648.165 Section... Atlantic Bluefish Fishery § 648.165 Framework specifications. Link to an amendment published at 76 FR 60641... through its annual review or framework adjustment process that minimum fish sizes are necessary to...

  13. 10 CFR 55.11 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Specific exemptions. 55.11 Section 55.11 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES Exemptions § 55.11 Specific exemptions. The Commission... endanger life or property and are otherwise in the public interest....

  14. 10 CFR 55.11 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Specific exemptions. 55.11 Section 55.11 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES Exemptions § 55.11 Specific exemptions. The Commission may, upon application by an interested person, or upon its own initiative, grant such exemptions from the requirements of the regulations...

  15. 46 CFR 170.160 - Specific applicability

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Specific applicability 170.160 Section 170.160 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY STABILITY REQUIREMENTS FOR ALL INSPECTED VESSELS Weather Criteria § 170.160 Specific applicability (a) Except as...

  16. 46 CFR 171.130 - Specific applicability.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Specific applicability. 171.130 Section 171.130 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO VESSELS CARRYING PASSENGERS Drainage of Weather Decks § 171.130 Specific applicability....

  17. 46 CFR 171.130 - Specific applicability.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Specific applicability. 171.130 Section 171.130 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO VESSELS CARRYING PASSENGERS Drainage of Weather Decks § 171.130 Specific applicability....

  18. 46 CFR 171.130 - Specific applicability.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Specific applicability. 171.130 Section 171.130 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO VESSELS CARRYING PASSENGERS Drainage of Weather Decks § 171.130 Specific applicability....

  19. 46 CFR 171.130 - Specific applicability.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Specific applicability. 171.130 Section 171.130 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO VESSELS CARRYING PASSENGERS Drainage of Weather Decks § 171.130 Specific applicability....

  20. 46 CFR 171.130 - Specific applicability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Specific applicability. 171.130 Section 171.130 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO VESSELS CARRYING PASSENGERS Drainage of Weather Decks § 171.130 Specific applicability....

  1. 14 CFR 25.1397 - Color specifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Color specifications. 25.1397 Section 25... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Equipment Lights § 25.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  2. 14 CFR 27.1397 - Color specifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Color specifications. 27.1397 Section 27... AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Equipment Lights § 27.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  3. 14 CFR 27.1397 - Color specifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Color specifications. 27.1397 Section 27... AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Equipment Lights § 27.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  4. 14 CFR 25.1397 - Color specifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Color specifications. 25.1397 Section 25... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Equipment Lights § 25.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  5. 14 CFR 29.1397 - Color specifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Color specifications. 29.1397 Section 29... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Lights § 29.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  6. 14 CFR 29.1397 - Color specifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Color specifications. 29.1397 Section 29... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Lights § 29.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  7. 14 CFR 23.1397 - Color specifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Color specifications. 23.1397 Section 23.1397 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... Color specifications. Each position light color must have the applicable International Commission...

  8. 14 CFR 23.1397 - Color specifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Color specifications. 23.1397 Section 23.1397 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... Color specifications. Each position light color must have the applicable International Commission...

  9. 14 CFR 27.1397 - Color specifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Color specifications. 27.1397 Section 27... AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Equipment Lights § 27.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  10. 14 CFR 23.1397 - Color specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Color specifications. 23.1397 Section 23.1397 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... Color specifications. Each position light color must have the applicable International Commission...

  11. 14 CFR 29.1397 - Color specifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Color specifications. 29.1397 Section 29... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Lights § 29.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  12. 14 CFR 25.1397 - Color specifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Color specifications. 25.1397 Section 25... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Equipment Lights § 25.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  13. 14 CFR 23.1397 - Color specifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Color specifications. 23.1397 Section 23.1397 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... Color specifications. Each position light color must have the applicable International Commission...

  14. 14 CFR 25.1397 - Color specifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Color specifications. 25.1397 Section 25... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Equipment Lights § 25.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  15. 14 CFR 29.1397 - Color specifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Color specifications. 29.1397 Section 29... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Lights § 29.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  16. 14 CFR 27.1397 - Color specifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Color specifications. 27.1397 Section 27... AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Equipment Lights § 27.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  17. 14 CFR 27.1397 - Color specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Color specifications. 27.1397 Section 27... AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Equipment Lights § 27.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  18. 14 CFR 25.1397 - Color specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Color specifications. 25.1397 Section 25... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Equipment Lights § 25.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  19. 14 CFR 23.1397 - Color specifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Color specifications. 23.1397 Section 23.1397 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... Color specifications. Each position light color must have the applicable International Commission...

  20. 14 CFR 29.1397 - Color specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Color specifications. 29.1397 Section 29... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Lights § 29.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  1. 10 CFR 52.7 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Specific exemptions. 52.7 Section 52.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General Provisions § 52.7 Specific exemptions. The Commission may, upon application by any interested person or...

  2. 10 CFR 52.7 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Specific exemptions. 52.7 Section 52.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General Provisions § 52.7 Specific exemptions. The Commission may, upon application by any interested person or...

  3. 10 CFR 52.7 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Specific exemptions. 52.7 Section 52.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General Provisions § 52.7 Specific exemptions. The Commission may, upon application by any interested person or...

  4. 10 CFR 52.7 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Specific exemptions. 52.7 Section 52.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General Provisions § 52.7 Specific exemptions. The Commission may, upon application by any interested person or...

  5. 10 CFR 52.7 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Specific exemptions. 52.7 Section 52.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General Provisions § 52.7 Specific exemptions. The Commission may, upon application by any interested person or...

  6. 21 CFR 1230.21 - Specific guaranty.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Specific guaranty. 1230.21 Section 1230.21 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... FEDERAL CAUSTIC POISON ACT Guaranty § 1230.21 Specific guaranty. If a guaranty in respect to any...

  7. 21 CFR 1230.21 - Specific guaranty.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Specific guaranty. 1230.21 Section 1230.21 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... FEDERAL CAUSTIC POISON ACT Guaranty § 1230.21 Specific guaranty. If a guaranty in respect to any...

  8. 21 CFR 1230.21 - Specific guaranty.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Specific guaranty. 1230.21 Section 1230.21 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... FEDERAL CAUSTIC POISON ACT Guaranty § 1230.21 Specific guaranty. If a guaranty in respect to any...

  9. 21 CFR 1230.21 - Specific guaranty.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Specific guaranty. 1230.21 Section 1230.21 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... FEDERAL CAUSTIC POISON ACT Guaranty § 1230.21 Specific guaranty. If a guaranty in respect to any...

  10. 21 CFR 1230.21 - Specific guaranty.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Specific guaranty. 1230.21 Section 1230.21 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... FEDERAL CAUSTIC POISON ACT Guaranty § 1230.21 Specific guaranty. If a guaranty in respect to any...

  11. 324/327 facilities environmental effluent specifications

    SciTech Connect

    JOHNSON, D.L.

    1998-10-29

    These effluent technical specifications address requirements for the 324/327 facilities, which are undergoing stabilization activities. Effluent technical specifications are imposed to protect personnel, the environment and the public, by ensuring adequate implementation and compliance with federal and state regulatory requirements and Hanford programs.

  12. 10 CFR 95.11 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Specific exemptions. 95.11 Section 95.11 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) FACILITY SECURITY CLEARANCE AND SAFEGUARDING OF NATIONAL SECURITY INFORMATION AND RESTRICTED DATA General Provisions § 95.11 Specific exemptions. The NRC may, upon...

  13. Stress and Specificity: Reply to Miller (2009)

    ERIC Educational Resources Information Center

    Denson, Thomas F.; Spanovic, Marija; Miller, Norman

    2009-01-01

    T. F. Denson, M. Spanovic, and N. Miller (2009) meta-analytically tested the hypotheses that specific appraisals and emotions would predict cortisol and immune responses to laboratory stressors and emotion inductions. Although the cortisol data supported the integrated specificity hypothesis, G. E. Miller (2009) raised questions concerning the…

  14. 12 CFR 347.119 - Specific consent.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Specific consent. 347.119 Section 347.119 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND STATEMENTS OF GENERAL POLICY INTERNATIONAL BANKING § 347.119 Specific consent. General consent and expedited processing under this subpart...

  15. 10 CFR 26.9 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Specific exemptions. 26.9 Section 26.9 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.9 Specific exemptions. Upon application of any interested person or on its own initiative, the Commission may grant such exemptions...

  16. 10 CFR 26.9 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Specific exemptions. 26.9 Section 26.9 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.9 Specific exemptions. Upon application of any interested person or on its own initiative, the Commission may grant such exemptions...

  17. 10 CFR 26.9 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Specific exemptions. 26.9 Section 26.9 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.9 Specific exemptions. Upon application of any interested person or on its own initiative, the Commission may grant such exemptions...

  18. 10 CFR 26.9 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Specific exemptions. 26.9 Section 26.9 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.9 Specific exemptions. Upon application of any interested person or on its own initiative, the Commission may grant such exemptions...

  19. 29 CFR 1918.52 - Specific requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 7 2013-07-01 2013-07-01 false Specific requirements. 1918.52 Section 1918.52 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR LONGSHORING Vessel's Cargo Handling Gear § 1918.52 Specific requirements. (a) Preventers. (1)...

  20. 40 CFR 86.1513 - Fuel specifications.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... § 86.1513 Fuel specifications. The requirements of this section are set forth in 40 CFR part 1065... 40 Protection of Environment 20 2013-07-01 2013-07-01 false Fuel specifications. 86.1513 Section 86.1513 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS...

  1. 40 CFR 86.1513 - Fuel specifications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... § 86.1513 Fuel specifications. The requirements of this section are set forth in 40 CFR part 1065... 40 Protection of Environment 19 2010-07-01 2010-07-01 false Fuel specifications. 86.1513 Section 86.1513 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS...

  2. 40 CFR 86.1513 - Fuel specifications.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... § 86.1513 Fuel specifications. The requirements of this section are set forth in 40 CFR part 1065... 40 Protection of Environment 20 2012-07-01 2012-07-01 false Fuel specifications. 86.1513 Section 86.1513 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS...

  3. 40 CFR 86.1513 - Fuel specifications.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., and Liquefied Petroleum Gas-Fueled Diesel-Cycle Light-Duty Trucks; Idle Test Procedures § 86.1513 Fuel specifications. The requirements of this section are set forth in 40 CFR part 1065, subpart H, for heavy-duty... 40 Protection of Environment 19 2014-07-01 2014-07-01 false Fuel specifications. 86.1513...

  4. 40 CFR 86.1513 - Fuel specifications.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... § 86.1513 Fuel specifications. The requirements of this section are set forth in 40 CFR part 1065... 40 Protection of Environment 19 2011-07-01 2011-07-01 false Fuel specifications. 86.1513 Section 86.1513 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS...

  5. Cell-Type-Specific Optogenetics in Monkeys.

    PubMed

    Namboodiri, Vijay Mohan K; Stuber, Garret D

    2016-09-01

    The recent advent of technologies enabling cell-type-specific recording and manipulation of neuronal activity spurred tremendous progress in neuroscience. However, they have been largely limited to mice, which lack the richness in behavior of primates. Stauffer et al. now present a generalizable method for achieving cell-type specificity in monkeys. PMID:27610562

  6. Specificity of marine microbial surface interactions.

    PubMed Central

    Imam, S H; Bard, R F; Tosteson, T R

    1984-01-01

    The macromolecular surface components involved in intraspecific cell surface interactions of the green microalga Chlorella vulgaris and closely associated bacteria were investigated. The specific surface attachment between this alga and its associated bacteria is mediated by lectin-like macromolecules associated with the surfaces of these cells. The binding activity of these surface polymers was inhibited by specific simple sugars; this suggests the involvement of specific receptor-ligand binding sites on the interactive surfaces. Epifluorescent microscopic evaluation of bacteria-alga interactions in the presence and absence of the macromolecules that mediate these interactions showed that the glycoproteins active in these processes were specific to the microbial sources from which they were obtained. The demonstration and definition of the specificity of these interactions in mixed microbial populations may play an important role in our understanding of the dynamics of marine microbial populations in the sea. PMID:6508293

  7. Tissue Specific Promoters in Colorectal Cancer

    PubMed Central

    Rama, A. R.; Aguilera, A.; Melguizo, C.; Caba, O.; Prados, J.

    2015-01-01

    Colorectal carcinoma is the third most prevalent cancer in the world. In the most advanced stages, the use of chemotherapy induces a poor response and is usually accompanied by other tissue damage. Significant progress based on suicide gene therapy has demonstrated that it may potentiate the classical cytotoxic effects in colorectal cancer. The inconvenience still rests with the targeting and the specificity efficiency. The main target of gene therapy is to achieve an effective vehicle to hand over therapeutic genes safely into specific cells. One possibility is the use of tumor-specific promoters overexpressed in cancers. They could induce a specific expression of therapeutic genes in a given tumor, increasing their localized activity. Several promoters have been assayed into direct suicide genes to cancer cells. This review discusses the current status of specific tumor-promoters and their great potential in colorectal carcinoma treatment. PMID:26648599

  8. Task-specific dystonia: pathophysiology and management.

    PubMed

    Sadnicka, Anna; Kassavetis, Panagiotis; Pareés, Isabel; Meppelink, Anne Marthe; Butler, Katherine; Edwards, Mark

    2016-09-01

    Task-specific dystonia is a form of isolated focal dystonia with the peculiarity of being displayed only during performance of a specific skilled motor task. This distinctive feature makes task-specific dystonia a particularly mysterious and fascinating neurological condition. In this review, we cover phenomenology and its increasingly broad-spectrum risk factors for the disease, critically review pathophysiological theories and evaluate current therapeutic options. We conclude by highlighting the unique features of task-specific dystonia within the wider concept of dystonia. We emphasise the central contribution of environmental risk factors, and propose a model by which these triggers may impact on the motor control of skilled movement. By viewing task-specific dystonia through this new lens which considers the disorder a modifiable disorder of motor control, we are optimistic that research will yield novel therapeutic avenues for this highly motivated group of patients.

  9. Structured representation for requirements and specifications

    NASA Technical Reports Server (NTRS)

    Cohen, Gerald C.; Fisher, Gene; Frincke, Deborah; Wolber, Dave

    1991-01-01

    This document was generated in support of NASA contract NAS1-18586, Design and Validation of Digital Flight Control Systems suitable for Fly-By-Wire Applications, Task Assignment 2. Task 2 is associated with a formal representation of requirements and specifications. In particular, this document contains results associated with the development of a Wide-Spectrum Requirements Specification Language (WSRSL) that can be used to express system requirements and specifications in both stylized and formal forms. Included with this development are prototype tools to support the specification language. In addition a preliminary requirements specification methodology based on the WSRSL has been developed. Lastly, the methodology has been applied to an Advanced Subsonic Civil Transport Flight Control System.

  10. Breckinridge Project, initial effort. Report III, Volume 2. Specifications

    SciTech Connect

    1982-01-01

    Report III, Volume 2 contains those specifications numbered K through Y, as follows: Specifications for Compressors (K); Specifications for Piping (L); Specifications for Structures (M); Specifications for Insulation (N); Specifications for Electrical (P); Specifications for Concrete (Q); Specifications for Civil (S); Specifications for Welding (W); Specifications for Painting (X); and Specifications for Special (Y). The standard specifications of Bechtel Petroleum Incorporated have been amended as necessary to reflect the specific requirements of the Breckinridge Project and the more stringent specifications of Ashland Synthetic Fuels, Inc. These standard specifications are available for the Initial Effort (Phase Zero) work performed by all contractors and subcontractors.

  11. Constructing specifications by combining parallel elaborations

    SciTech Connect

    Feather, M.S.

    1989-02-01

    Constructing specifications of complex tasks is often a laborious activity in spite of the rich vocabulary provided by specification languages. An incremental approach to construction is proposed, with the virtue of offering considerable opportunity for mechanized support. Following this approach one builds a specification through a series of elaborations that incrementally adjust a simple initial specification. Elaborations perform both refinements, adding further detail, and adaptations, retracting oversimplifications and tailoring approximations to the specifics of the task. It is anticipated that the vast majority of elaborations can be concisely described to a mechanism which will then perform them automatically. When elaborations are independent, they can be applied in parallel, leading to diverging specifications which must later be recombined. The approach is intended to facilitate comprehension and maintenance of specifications, as well as their initial construction. The advantages of following this approach stem from the gradual nature of the elaboration process, the separation of concerns through following independent elaborations in parallel, the simplicity of the individual elaboration steps (the effects of each step are well delineated), and the availability of an explicit record of construction.

  12. Benchmark Generation using Domain Specific Modeling

    SciTech Connect

    Bui, Ngoc B.; Zhu, Liming; Gorton, Ian; Liu, Yan

    2007-08-01

    Performance benchmarks are domain specific applications that are specialized to a certain set of technologies and platforms. The development of a benchmark application requires mapping the performance specific domain concepts to an implementation and producing complex technology and platform specific code. Domain Specific Modeling (DSM) promises to bridge the gap between application domains and implementations by allowing designers to specify solutions in domain-specific abstractions and semantics through Domain Specific Languages (DSL). This allows generation of a final implementation automatically from high level models. The modeling and task automation benefits obtained from this approach usually justify the upfront cost involved. This paper employs a DSM based approach to invent a new DSL, DSLBench, for benchmark generation. DSLBench and its associated code generation facilities allow the design and generation of a completely deployable benchmark application for performance testing from a high level model. DSLBench is implemented using Microsoft Domain Specific Language toolkit. It is integrated with the Visual Studio 2005 Team Suite as a plug-in to provide extra modeling capabilities for performance testing. We illustrate the approach using a case study based on .Net and C#.

  13. The classic cadherins in synaptic specificity

    PubMed Central

    Basu, Raunak; Taylor, Matthew R; Williams, Megan E

    2015-01-01

    During brain development, billions of neurons organize into highly specific circuits. To form specific circuits, neurons must build the appropriate types of synapses with appropriate types of synaptic partners while avoiding incorrect partners in a dense cellular environment. Defining the cellular and molecular rules that govern specific circuit formation has significant scientific and clinical relevance because fine scale connectivity defects are thought to underlie many cognitive and psychiatric disorders. Organizing specific neural circuits is an enormously complicated developmental process that requires the concerted action of many molecules, neural activity, and temporal events. This review focuses on one class of molecules postulated to play an important role in target selection and specific synapse formation: the classic cadherins. Cadherins have a well-established role in epithelial cell adhesion, and although it has long been appreciated that most cadherins are expressed in the brain, their role in synaptic specificity is just beginning to be unraveled. Here, we review past and present studies implicating cadherins as active participants in the formation, function, and dysfunction of specific neural circuits and pose some of the major remaining questions. PMID:25837840

  14. Seismic vulnerability evaluation of axially loaded steel built-up laced members II: evaluations

    NASA Astrophysics Data System (ADS)

    Lee, Kangmin; Bruneau, Michel

    2008-06-01

    The test results described in Part 1 of this paper (Lee and Bruneau, 2008) on twelve steel built-up laced members (BLMs) subjected to quasi-static loading are analyzed to provide better knowledge on their seismic behavior. Strength capacity of the BLM specimens is correlated with the strength predicted by the AISC LRFD Specifications. Assessments of hysteretic properties such as ductility capacity, energy dissipation capacity, and strength degradation after buckling of the specimen are performed. The compressive strength of BLMs is found to be relatively well predicted by the AISC LRFD Specifications. BLMs with smaller kl/r were ductile but failed to reach the target ductility of 3.0 before starting to fracture, while those with larger kl/r could meet the ductility demand in most cases. The normalized energy dissipation ratio, E C/ E T and the normalized compressive strength degradation, C r″/ C r of BLMs typically decrease as normalized displacements δ/ δ b,exp increase, and the ratios for specimens with larger kl/r dropped more rapidly than for specimens with smaller kl/r; similar trends were observed for the monolithic braces. The BLMs with a smaller slenderness ratio, kl/r, and width-to-thickness ratio, b/t, experienced a larger number of inelastic cycles than those with larger ratios.

  15. Cell specific, variable density, polymer microspheres

    NASA Technical Reports Server (NTRS)

    Yen, Shiao-Ping S. (Inventor); Rembaum, Alan (Inventor); Molday, Robert S. (Inventor)

    1977-01-01

    Biocompatible polymeric microspheres having an average diameter below about 3 microns and having density at least 15% greater or lesser than organic cells and having covalent binding sites are provided in accordance with this invention. The microspheres are obtained by copolymerizing a hydroxy or amine substituted acrylic monomer such as hydroxyethylmethacrylate with a light or dense comonomer such as a fluoromonomer. A lectin or antibody is bound to the hydroxy or amine site of the bead to provide cell specificity. When added to a cell suspension the marked bead will specifically label the cell membrane by binding to specific receptor sites thereon. The labelled membrane can then be separated by density gradient centrifugation.

  16. Bias and design in software specifications

    NASA Technical Reports Server (NTRS)

    Straub, Pablo A.; Zelkowitz, Marvin V.

    1990-01-01

    Implementation bias in a specification is an arbitrary constraint in the solution space. Presented here is a model of bias in software specifications. Bias is defined in terms of the specification process and a classification of the attributes of the software product. Our definition of bias provides insight into both the origin and the consequences of bias. It also shows that bias is relative and essentially unavoidable. Finally, we describe current work on defining a measure of bias, formalizing our model, and relating bias to software defects.

  17. 60% Review technical specifications, Deaf Smith Site

    SciTech Connect

    Gast, R.A.

    1987-08-01

    The enclosed documentation for the 60% Review Technical Specifications, Deaf Smith Site includes: Solicitation Documents which represent the eventual Federal Acquisition Regulations (FARs) and Department of Energy Acquisition Regulations (DEARs) that will comprise a segment of the contractual documents for bidders attention; Contract Clauses that will become integral parts for the Fixed Price Construction Contracts applicable to the Exploratory Shaft Facility; Special Contract Requirements that will become contract provisions requiring specific contractor attention; Technical Specifications which have been completed for 60% submission, and the current list of 241 Contract Drawings that have been separately forwarded for review and comment.

  18. Generation of licensee-controlled specifications

    SciTech Connect

    Woods, B.; McLeod, T.J. )

    1991-01-01

    The US Nuclear Regulatory Commission (NRC) and the nuclear industry have worked jointly towards redeveloping plant standard technical specifications (STS) through inception of the Technical Specification Improvement Project. Through application of objective screening criteria coupled with an NRC generic letter authorized to remove requirements from STS, former STS requirements would be relocated to programs controlled by the licensee. This paper discusses the orderly and accountable transfer of these requirements, and the promulgation of additional desired licensee requirements to the new licensee-controlled specifications.

  19. Literacy and children with specific language impairment.

    PubMed

    Schuele, C Melanie; Spencer, Elizabeth J; Barako-Arndt, Karen; Guillot, Kathryn M

    2007-02-01

    The purpose of this article is to summarize the literacy outcomes for children with specific language impairment and to consider principles and approaches for literacy intervention with preschool and early school-age children with language impairments. Initially, specific language impairment is defined and differentiated from nonspecific language impairment. In addressing intervention considerations, we first consider the application of best practice principles and then specifically focus on intervention with preschool children and intervention with early school-age children. Consideration of evidence-based treatment approaches is guided by the developmental literature and by the intervention literature. PMID:17340381

  20. A novel monoclonal antibody specific for cocaine.

    PubMed

    Nakayama, Hiroshi; Kenjyou, Noriko; Shigetoh, Nobuyuki

    2013-08-01

    Detection systems for the illegal drug cocaine need to have a high sensitivity and specificity for cocaine and to be relatively easy to use. In the current study, a monoclonal antibody (MAb) with a high specificity for cocaine was produced. Enzyme-linked immunosorbent assay and fluorescence quenching immunoassay were used to screen the hybridomas. The MAb S27Y (IgG1) was shown to be sensitive and specific for cocaine and quenched fluorescence. Thus, S27Y has the potential to be used in screening assays for the rapid and sensitive detection of cocaine. PMID:23909419

  1. Specific Impulse Definition for Ablative Laser Propulsion

    NASA Astrophysics Data System (ADS)

    Gregory, Don A.; Herren, Kenneth A.

    2005-04-01

    The term "specific impulse" is so ingrained in the field of rocket propulsion that it is unlikely that any fundamental argument would be taken seriously for its removal. It is not an ideal measure but it does give an indication of the amount of mass flow (mass loss/time), as in fuel rate, required to produce a measured thrust over some time period. This investigation explores the implications of being able to accurately measure the ablation rate and how the language used to describe the specific impulse results may have to change slightly, and recasts the specific impulse as something that is not a time average. It is not currently possible to measure the ablation rate accurately in real time so it is generally just assumed that a constant amount of material will be removed for each laser pulse delivered. The specific impulse dependence on the ablation rate is determined here as a correction to the classical textbook definition.

  2. 2nd Generation ELT Performance Specification Development

    NASA Technical Reports Server (NTRS)

    Stimson, Chad M.

    2015-01-01

    NASA Search And Rescue is supporting RTCA SC-229 with research and recommendations for performance specifications for the 2nd generation of emergency locator transmitters. Areas for improvement and methods for collecting data will be presented.

  3. Gender-Specific Health Challenges Facing Women

    MedlinePlus

    ... Specific Health Challenges Facing Women Questions and Answers Science Advances Skip Website Tools Website Tools Print this page Get email updates Order publications Volunteer for Clinical Studies Help improve ...

  4. Specific Programmatic Strategies to Increase Empowerment.

    ERIC Educational Resources Information Center

    Kohn, Sandy

    1991-01-01

    Advocates empowering students to help them take control of their lives. Provides specific ideas on how educators can facilitate this process. Uses concepts from humanistic education, group dynamics, Quaker thought and action, and experiential programing. (KS)

  5. Specifications and programs for computer software validation

    NASA Technical Reports Server (NTRS)

    Browne, J. C.; Kleir, R.; Davis, T.; Henneman, M.; Haller, A.; Lasseter, G. L.

    1973-01-01

    Three software products developed during the study are reported and include: (1) FORTRAN Automatic Code Evaluation System, (2) the Specification Language System, and (3) the Array Index Validation System.

  6. Scintimammography (Breast Specific Gamma Imaging-BSGI)

    MedlinePlus

    ... computer to help investigate an abnormality discovered on mammography. Its ability to detect cancer is not limited ... a breast abnormality that has been discovered on mammography. Scintimammography is also known as Breast Specific Gamma ...

  7. Surface cleanliness of fluid systems, specification for

    NASA Technical Reports Server (NTRS)

    1995-01-01

    This specification establishes surface cleanliness levels, test methods, cleaning and packaging requirements, and protection and inspection procedures for determining surface cleanliness. These surfaces pertain to aerospace parts, components, assemblies, subsystems, and systems in contact with any fluid medium.

  8. 40 CFR 247.5 - Specifications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... GUIDELINE FOR PRODUCTS CONTAINING RECOVERED MATERIALS General § 247.5 Specifications. (a) RCRA section 6002... virgin materials. (b) RCRA section 6002(d)(2) requires that within one year after the publication date...

  9. 40 CFR 247.5 - Specifications.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... GUIDELINE FOR PRODUCTS CONTAINING RECOVERED MATERIALS General § 247.5 Specifications. (a) RCRA section 6002... virgin materials. (b) RCRA section 6002(d)(2) requires that within one year after the publication date...

  10. 40 CFR 247.5 - Specifications.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... GUIDELINE FOR PRODUCTS CONTAINING RECOVERED MATERIALS General § 247.5 Specifications. (a) RCRA section 6002... virgin materials. (b) RCRA section 6002(d)(2) requires that within one year after the publication date...

  11. 40 CFR 247.5 - Specifications.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... GUIDELINE FOR PRODUCTS CONTAINING RECOVERED MATERIALS General § 247.5 Specifications. (a) RCRA section 6002... virgin materials. (b) RCRA section 6002(d)(2) requires that within one year after the publication date...

  12. 40 CFR 247.5 - Specifications.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... GUIDELINE FOR PRODUCTS CONTAINING RECOVERED MATERIALS General § 247.5 Specifications. (a) RCRA section 6002... virgin materials. (b) RCRA section 6002(d)(2) requires that within one year after the publication date...

  13. Secretin: specific binding to rat brain membranes

    SciTech Connect

    Fremeau, R.T. Jr.; Jensen, R.T.; Charlton, C.G.; Miller, R.L.; O'Donohue, T.L.; Moody, T.W.

    1983-08-01

    The binding of (/sup 125/I)secretin to rat brain membranes was investigated. Radiolabeled secretin bound with high affinity (KD . 0.2 nM) to a single class of noninteracting sites. Binding was specific, saturable, and reversible. Regional distribution studies indicated that the specific binding was greatest in the cerebellum, intermediate in the cortex, thalamus, striatum, hippocampus, and hypothalamus, and lowest in the midbrain and medulla/pons. Pharmacological studies indicated that only secretin, but not other peptides, inhibits binding of (/sup 125/I)secretin with high affinity. Also, certain guanine nucleotides inhibited high affinity binding. These data indicate that rat brain membranes possess high affinity binding sites specific for secretin and that with the use of (/sup 125/I) secretin the kinetics, stoichiometry, specificity, and distribution of secretin receptors can be directly investigated.

  14. UPC Language Specifications V1.2

    SciTech Connect

    UPC Consortium

    2005-05-31

    UPC is an explicitly parallel extension to the ISO C 99Standard. UPC follows the partitioned global address space programming model. This document is the formal specification for the UPC language syntax and semantics.

  15. Cockpit management and Specific Behavioral Objectives (SBOs)

    NASA Technical Reports Server (NTRS)

    Mudge, R. W.

    1987-01-01

    One of the primary tools used to accomplish the task of effective training is the specific behavioral objective (SBO). An SBO is simply a statement which specifically identifies a small segment of the final behavior sought, and a little more. The key word is specific. The company pinpoints exactly what it is it wants the pilot to do after completing training, and what it should evaluate from the point of view of both the program and the pilot. It tells the junior crewmember exactly, specifically, what he should monitor and support insofar as the management function is concerned. It gives greater meaning to the term second in command. And finally, it tells the supervisory pilot exactly what he should observe, evaluate, and instruct, insofar as the management function is concerned.

  16. Patient-specific Modeling of Cardiovascular Mechanics

    PubMed Central

    Taylor, C.A.; Figueroa, C.A.

    2015-01-01

    Advances in numerical methods and three-dimensional imaging techniques have enabled the quantification of cardiovascular mechanics in subject-specific anatomic and physiologic models. Patient-specific models are being used to guide cell culture and animal experiments and test hypotheses related to the role of biomechanical factors in vascular diseases. Furthermore, biomechanical models based on noninvasive medical imaging could provide invaluable data on the in vivo service environment where cardiovascular devices are employed and the effect of the devices on physiologic function. Finally, the patient-specific modeling has enabled an entirely new application of cardiovascular mechanics, namely predicting outcomes of alternate therapeutic interventions for individual patients. We will review methods to create anatomic and physiologic models, obtain properties, assign boundary conditions, and solve the equations governing blood flow and vessel wall dynamics. Applications of patient-specific models of cardiovascular mechanics will be presented followed by a discussion of the challenges and opportunities that lie ahead. PMID:19400706

  17. High Flux Isotope Reactor technical specifications

    SciTech Connect

    Not Available

    1985-11-01

    This report gives technical specifications for the High Flux Isotope Reactor (HFIR) on the following: safety limits and limiting safety system settings; limiting conditions for operation; surveillance requirements; design features; and administrative controls.

  18. Finding Specification Pages from the Web

    NASA Astrophysics Data System (ADS)

    Yoshinaga, Naoki; Torisawa, Kentaro

    This paper presents a method of finding a specification page on the Web for a given object (e.g., ``Ch. d'Yquem'') and its class label (e.g., ``wine''). A specification page for an object is a Web page which gives concise attribute-value information about the object (e.g., ``county''-``Sauternes'') in well formatted structures. A simple unsupervised method using layout and symbolic decoration cues was applied to a large number of the Web pages to acquire candidate attributes for each class (e.g., ``county'' for a class ``wine''). We then filter out irrelevant words from the putative attributes through an author-aware scoring function that we called site frequency. We used the acquired attributes to select a representative specification page for a given object from the Web pages retrieved by a normal search engine. Experimental results revealed that our system greatly outperformed the normal search engine in terms of this specification retrieval.

  19. Specific Impulse Definition for Ablative Laser Propulsion

    NASA Technical Reports Server (NTRS)

    Herren, Kenneth A.; Gregory, Don A.

    2004-01-01

    The term "specific impulse" is so ingrained in the field of rocket propulsion that it is unlikely that any fundamental argument would be taken seriously for its removal. It is not an ideal measure but it does give an indication of the amount of mass flow (mass loss/time), as in fuel rate, required to produce a measured thrust over some time period This investigation explores the implications of being able to accurately measure the ablation rate and how the language used to describe the specific impulse results may have to change slightly, and recasts the specific impulse as something that is not a time average. It is not currently possible to measure the ablation rate accurately in real time so it is generally just assumed that a constant amount of material will be removed for each laser pulse delivered The specific impulse dependence on the ablation rate is determined here as a correction to the classical textbook definition.

  20. Slicing AADL Specifications for Model Checking

    NASA Technical Reports Server (NTRS)

    Odenbrett, Maximilian; Nguyen, Viet Yen; Noll, Thomas

    2010-01-01

    To combat the state-space explosion problem in model checking larger systems, abstraction techniques can be employed. Here, methods that operate on the system specification before constructing its state space are preferable to those that try to minimize the resulting transition system as they generally reduce peak memory requirements. We sketch a slicing algorithm for system specifications written in (a variant of) the Architecture Analysis and Design Language (AADL). Given a specification and a property to be verified, it automatically removes those parts of the specification that are irrelevant for model checking the property, thus reducing the size of the corresponding transition system. The applicability and effectiveness of our approach is demonstrated by analyzing the state-space reduction for an example, employing a translator from AADL to Promela, the input language of the SPIN model checker.

  1. Specification For ST-5 Li Ion Battery

    NASA Technical Reports Server (NTRS)

    Castell, Karen D.; Day, John H. (Technical Monitor)

    2000-01-01

    This Specification defines the general requirements for rechargeable Space Flight batteries intended for use in the ST-5 program. The battery chemistry chosen for this mission is lithium ion (Li-Ion).

  2. 32 CFR 292.4 - Specific policy.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... INFORMATION ACT PROGRAM DEFENSE INTELLIGENCE AGENCY (DIA) FREEDOM OF INFORMATION ACT § 292.4 Specific policy... characteristics, made or received by the DIA in connection with the transaction of public business and in the...

  3. 14 CFR 221.40 - Specific requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) ECONOMIC REGULATIONS TARIFFS Contents of Tariff § 221.40 Specific requirements. (a) In addition to the... such service by manufacturer model designation and a description of the seating configuration...

  4. 48 CFR 836.202 - Specifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... specifications. (b) During the design stage, contract architect-engineers must not use “brand name or equal” or.... This clause places bidders on notice that the “brand name or equal” provisions of the clause found...

  5. 48 CFR 36.202 - Specifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... technical societies. (c) When brand name or equal descriptions are necessary, specifications must clearly identify and describe the particular physical, functional, or other characteristics of the brand-name...

  6. 48 CFR 36.202 - Specifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... technical societies. (c) When brand name or equal descriptions are necessary, specifications must clearly identify and describe the particular physical, functional, or other characteristics of the brand-name...

  7. 50 CFR 648.200 - Specifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Herring Fishery § 648.200 Specifications. (a) The Atlantic Herring Plan Development Team (PDT) shall meet... overfishing is not occurring, this is usually the fishing rate supporting maximum sustainable yield...

  8. 50 CFR 648.200 - Specifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Herring Fishery § 648.200 Specifications. (a) The Atlantic Herring Plan Development Team (PDT) shall meet... overfishing is not occurring, this is usually the fishing rate supporting maximum sustainable yield...

  9. 50 CFR 648.200 - Specifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Herring Fishery § 648.200 Specifications. (a) The Atlantic Herring Plan Development Team (PDT) shall meet... overfishing is not occurring, this is usually the fishing rate supporting maximum sustainable yield...

  10. 50 CFR 648.200 - Specifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Herring Fishery § 648.200 Specifications. (a) The Atlantic Herring Plan Development Team (PDT) shall meet... overfishing is not occurring, this is usually the fishing rate supporting maximum sustainable yield...

  11. Process Specification for Eddy Current Inspection

    NASA Technical Reports Server (NTRS)

    Koshti, Ajay

    2011-01-01

    This process specification establishes the minimum requirements for eddy current inspection of flat surfaces, fastener holes, threaded fasteners and seamless and welded tubular products made from nonmagnetic alloys such as aluminum and stainless steel.

  12. Double Shell Tank (DST) Utilities Specification

    SciTech Connect

    SUSIENE, W.T.

    2000-04-27

    This specification establishes the performance requirements and provides the references to the requisite codes and standards to he applied during the design of the Double-Shell Tank (DST) Utilities Subsystems that support the first phase of waste feed delivery (WFD). The DST Utilities Subsystems provide electrical power, raw/potable water, and service/instrument air to the equipment and structures used to transfer low-activity waste (LAW) and high-level waste (HLW) to designated DST staging tanks. The DST Utilities Subsystems also support the equipment and structures used to deliver blended LAW and HLW feed from these staging tanks to the River Protection Project (RPP) Privatization Contractor facility where the waste will be immobilized. This specification is intended to be the basis for new projects/installations. This specification is not intended to retroactively affect previously established project design criteria without specific direction by the program.

  13. Technical requirements specification for tank waste retrieval

    SciTech Connect

    Lamberd, D.L.

    1996-09-26

    This document provides the technical requirements specification for the retrieval of waste from the underground storage tanks at the Hanford Site. All activities covered by this scope are conducted in support of the Tank Waste Remediation System (TWRS) mission.

  14. Measuring Specific Heats at High Temperatures

    NASA Technical Reports Server (NTRS)

    Vandersande, Jan W.; Zoltan, Andrew; Wood, Charles

    1987-01-01

    Flash apparatus for measuring thermal diffusivities at temperatures from 300 to 1,000 degrees C modified; measures specific heats of samples to accuracy of 4 to 5 percent. Specific heat and thermal diffusivity of sample measured. Xenon flash emits pulse of radiation, absorbed by sputtered graphite coating on sample. Sample temperature measured with thermocouple, and temperature rise due to pulse measured by InSb detector.

  15. Specific Impulse and Mass Flow Rate Error

    NASA Technical Reports Server (NTRS)

    Gregory, Don A.

    2005-01-01

    Specific impulse is defined in words in many ways. Very early in any text on rocket propulsion a phrase similar to .specific impulse is the thrust force per unit propellant weight flow per second. will be found.(2) It is only after seeing the mathematics written down does the definition mean something physically to scientists and engineers responsible for either measuring it or using someone.s value for it.

  16. Allergen-specific immunotherapy in atopic eczema.

    PubMed

    Darsow, Ulf; Forer, Ingeborg; Ring, Johannes

    2011-08-01

    Aeroallergens are relevant eliciting factors of allergic rhinoconjunctivitis and bronchial asthma but also of atopic eczema. The use of allergen-specific immunotherapy as in respiratory atopic diseases is controversial in patients with atopic eczema, but refined diagnostic methods to characterize subgroups of patients with relevant allergies and the results of smaller controlled studies give rise to new approaches in this field. This article reviews the theoretical problems and practical results associated with allergen-specific immunotherapy in atopic eczema. PMID:21461718

  17. FTP Extensions for Variable Protocol Specification

    NASA Technical Reports Server (NTRS)

    Allman, Mark; Ostermann, Shawn

    2000-01-01

    The specification for the File Transfer Protocol (FTP) assumes that the underlying network protocols use a 32-bit network address and a 16-bit transport address (specifically IP version 4 and TCP). With the deployment of version 6 of the Internet Protocol, network addresses will no longer be 32-bits. This paper species extensions to FTP that will allow the protocol to work over a variety of network and transport protocols.

  18. Simple Benchmark Specifications for Space Radiation Protection

    NASA Technical Reports Server (NTRS)

    Singleterry, Robert C. Jr.; Aghara, Sukesh K.

    2013-01-01

    This report defines space radiation benchmark specifications. This specification starts with simple, monoenergetic, mono-directional particles on slabs and progresses to human models in spacecraft. This report specifies the models and sources needed to what the team performing the benchmark needs to produce in a report. Also included are brief descriptions of how OLTARIS, the NASA Langley website for space radiation analysis, performs its analysis.

  19. Language translation, doman specific languages and ANTLR

    NASA Technical Reports Server (NTRS)

    Craymer, Loring; Parr, Terence

    2002-01-01

    We will discuss the features of ANTLR that make it an attractive tool for rapid developement of domain specific language translators and present some practical examples of its use: extraction of information from the Cassini Command Language specification, the processing of structured binary data, and IVL--an English-like language for generating VRML scene graph, which is used in configuring the jGuru.com server.

  20. Autobiographical memory specificity in dissociative identity disorder.

    PubMed

    Huntjens, Rafaële J C; Wessel, Ineke; Hermans, Dirk; van Minnen, Agnes

    2014-05-01

    A lack of adequate access to autobiographical knowledge has been related to psychopathology. More specifically, patients suffering from depression or a history of trauma have been found to be characterized by overgeneral memory, in other words, they show a relative difficulty in retrieving a specific event from memory located in time and place. Previous studies of overgeneral memory have not included patients with dissociative disorders. These patients are interesting to consider, as they are hypothesized to have the ability to selectively compartmentalize information linked to negative emotions. This study examined avoidance and overgeneral memory in patients with dissociative identity disorder (DID; n = 12). The patients completed the autobiographical memory test (AMT). Their performance was compared with control groups of posttraumatic stress disorder (PTSD) patients (n = 26), healthy controls (n = 29), and DID simulators (n = 26). Specifically, we compared the performance of separate identity states in DID hypothesized to diverge in the use of avoidance as a coping strategy to deal with negative affect. No significant differences in memory specificity were found between the separate identities in DID. Irrespective of identity state, DID patients were characterized by a lack of memory specificity, which was similar to the lack of memory specificity found in PTSD patients. The converging results for DID and PTSD patients add empirical evidence for the role of overgeneral memory involved in the maintenance of posttraumatic psychopathology. PMID:24886016

  1. Transcriptional regulation of glial cell specification.

    PubMed

    Ragone, Gianluca; Van De Bor, Véronique; Sorrentino, Sandro; Kammerer, Martial; Galy, Anne; Schenck, Annette; Bernardoni, Roberto; Miller, Alita A; Roy, Nivedita; Giangrande, Angela

    2003-03-01

    Neuronal differentiation relies on proneural factors that also integrate positional information and contribute to the specification of the neuronal type. The molecular pathway triggering glial specification is not understood yet. In Drosophila, all lateral glial precursors and glial-promoting activity have been identified, which provides us with a unique opportunity to dissect the regulatory pathways controlling glial differentiation and specification. Although glial lineages are very heterogeneous with respect to position, time of differentiation, and lineage tree, they all express and require two homologous genes, glial cell deficient/glial cell missing (glide/gcm) and glide2, that act in concert, with glide/gcm constituting the major glial-promoting factor. Here, we show that glial specification resides in glide/gcm transcriptional regulation. The glide/gcm promoter contains lineage-specific elements as well as quantitative and turmoil elements scattered throughout several kilobases. Interestingly, there is no correlation between a specific regulatory element and the type of glial lineage. Thus, the glial-promoting factor acts as a naive switch-on button that triggers gliogenesis in response to multiple pathways converging onto its promoter. Both negative and positive regulation are required to control glide/gcm expression, indicating that gliogenesis is actively repressed in some neural lineages. PMID:12618139

  2. Autobiographical memory specificity in dissociative identity disorder.

    PubMed

    Huntjens, Rafaële J C; Wessel, Ineke; Hermans, Dirk; van Minnen, Agnes

    2014-05-01

    A lack of adequate access to autobiographical knowledge has been related to psychopathology. More specifically, patients suffering from depression or a history of trauma have been found to be characterized by overgeneral memory, in other words, they show a relative difficulty in retrieving a specific event from memory located in time and place. Previous studies of overgeneral memory have not included patients with dissociative disorders. These patients are interesting to consider, as they are hypothesized to have the ability to selectively compartmentalize information linked to negative emotions. This study examined avoidance and overgeneral memory in patients with dissociative identity disorder (DID; n = 12). The patients completed the autobiographical memory test (AMT). Their performance was compared with control groups of posttraumatic stress disorder (PTSD) patients (n = 26), healthy controls (n = 29), and DID simulators (n = 26). Specifically, we compared the performance of separate identity states in DID hypothesized to diverge in the use of avoidance as a coping strategy to deal with negative affect. No significant differences in memory specificity were found between the separate identities in DID. Irrespective of identity state, DID patients were characterized by a lack of memory specificity, which was similar to the lack of memory specificity found in PTSD patients. The converging results for DID and PTSD patients add empirical evidence for the role of overgeneral memory involved in the maintenance of posttraumatic psychopathology.

  3. The specification of imprints in mammals.

    PubMed

    Hanna, C W; Kelsey, G

    2014-08-01

    At the heart of genomic imprinting in mammals are imprinting control regions (ICRs), which are the discrete genetic elements that confer imprinted monoallelic expression to several genes in imprinted gene clusters. A characteristic of the known ICRs is that they acquire different epigenetic states, exemplified by differences in DNA methylation, in the sperm and egg, and these imprint marks remain on the sperm- and oocyte-derived alleles into the next generation as a lifelong memory of parental origin. Although there has been much focus on gametic marking of ICRs as the point of imprint specification, recent mechanistic studies and genome-wide DNA methylation profiling do not support the existence of a specific imprinting machinery in germ cells. Rather, ICRs are part of more widespread methylation events that occur during gametogenesis. Instead, a decisive component in the specification of imprints is the choice of which sites of gamete-derived methylation to maintain in the zygote and preimplantation embryo at a time when much of the remainder of the genome is being demethylated. Among the factors involved in this selection, the zinc-finger protein Zfp57 can be regarded as an imprint-specific, sequence-specific DNA binding factor responsible for maintaining methylation at most ICRs. The recent insights into the balance of gametic and zygotic contributions to imprint specification should help understand mechanistic opportunities and constraints on the evolution of imprinting in mammals.

  4. Germ cell specification and regeneration in planarians.

    PubMed

    Newmark, P A; Wang, Y; Chong, T

    2008-01-01

    In metazoans, two apparently distinct mechanisms specify germ cell fate: Determinate specification (observed in animals including Drosophila, Caenorhabditis elegans, zebra fish, and Xenopus) uses cytoplasmic factors localized to specific regions of the egg, whereas epigenetic specification (observed in many basal metazoans, urodeles, and mammals) involves inductive interactions between cells. Much of our understanding of germ cell specification has emerged from studies of model organisms displaying determinate specification. In contrast, our understanding of epigenetic/inductive specification is less advanced and would benefit from studies of additional organisms. Freshwater planarians--widely known for their remarkable powers of regeneration--are well suited for studying the mechanisms by which germ cells can be induced. Classic experiments showed that planarians can regenerate germ cells from body fragments entirely lacking reproductive structures, suggesting that planarian germ cells could be specified by inductive signals. Furthermore, the availability of the genome sequence of the planarian Schmidtea mediterranea, coupled with the animal's susceptibility to systemic RNA interference (RNAi), facilitates functional genomic analyses of germ cell development and regeneration. Here, we describe recent progress in studies of planarian germ cells and frame some of the critical unresolved questions for future work.

  5. 77 FR 27490 - Plant-Specific Adoption, Revision 4 of the Improved Standard Technical Specifications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-10

    ... Electric Plants, BWR/4,'' and NUREG-1434, ``Standard Technical Specifications, General Electric Plants, BWR... ML12104A193 (Bases), and NUREG-1434, ``Standard Technical Specifications, General Electric Plants, BWR/6... ML12104A193 Specifications, General Electric BWR/4 Plants'' NUREG-1434, ``Standard Technical...

  6. Ultrasensitive Responses and Specificity in Cell Signaling

    PubMed Central

    2010-01-01

    Background Interconnected cell signaling pathways are able to efficiently and accurately transmit a multitude of different signals, despite an inherent potential for undesirable levels of cross-talk. To ensure that an appropriate response is produced, biological systems have evolved network-level mechanisms that insulate pathways from crosstalk and prevent 'leaking' or 'spillover' between pathways. Many signaling pathways have been shown to respond in an ultrasensitive (switch-like) fashion to graded input, and this behavior may influence specificity. The relationship of ultrasensitivity to signaling specificity has not been extensively explored. Results We studied the behavior of simple mathematical models of signaling networks composed of two interconnected pathways that share an intermediate component, asking if the two pathways in the network could exhibit both output specificity (preferentially activate their own output) and input fidelity (preferentially respond to their own input). Previous results with weakly-activated pathways indicated that neither mutual specificity nor mutual fidelity were obtainable in the absence of an insulating mechanism, such as cross-pathway inhibition, combinatorial signaling or scaffolding/compartmentalization. Here we found that mutual specificity is obtainable for hyperbolic or ultrasensitive pathways, even in the absence of an insulating mechanism. However, mutual fidelity is impossible at steady-state, even if pathways are hyperbolic or ultrasensitive. Nevertheless, ultrasensitivity does provide advantages in attaining specificity and fidelity to networks that contain an insulating mechanism. For networks featuring cross-pathway inhibition or combinatorial signaling, ultrasensitive activation can increase specificity in a limited way, and can only be utilized by one of the two pathways. In contrast, for networks featuring scaffolding/compartmentalization, ultrasensitive activation of both pathways can dramatically improve

  7. Disease-Specific Probabilistic Brain Atlases

    PubMed Central

    Thompson, Paul; Mega, Michael S.; Toga, Arthur W.

    2009-01-01

    Atlases of the human brain, in health and disease, provide a comprehensive framework for understanding brain structure and function. The complexity and variability of brain structure, especially in the gyral patterns of the human cortex, present challenges in creating standardized brain atlases that reflect the anatomy of a population. This paper introduces the concept of a population-based, disease-specific brain atlas that can reflect the unique anatomy and physiology of a particular clinical subpopulation. Based on well-characterized patient groups, disease-specific atlases contain thousands of structure models, composite maps, average templates, and visualizations of structural variability, asymmetry and group-specific differences. They correlate the structural, metabolic, molecular and histologic hallmarks of the disease. Rather than simply fusing information from multiple subjects and sources, new mathematical strategies are introduced to resolve group-specific features not apparent in individual scans. High-dimensional elastic mappings, based on covariant partial differential equations, are developed to encode patterns of cortical variation. In the resulting brain atlas, disease-specific features and regional asymmetries emerge that are not apparent in individual anatomies. The resulting probabilistic atlas can identify patterns of altered structure and function, and can guide algorithms for knowledge-based image analysis, automated image labeling, tissue classification, data mining and functional image analysis. PMID:19424457

  8. Generation of antiserum to specific epitopes.

    PubMed

    Marchion, D C; Manning, D S; Shafer, W M; Judd, R C

    1996-12-01

    The ability to prevent disease by immunization with subunit vaccines that incorporate specific epitopes was demonstrated by DiMarchi et al. (1), who used a synthetic peptide to protect cattle against foot-and-mouth disease. However, generation of antibody to peptide antigens is often difficult owing to the small molecular mass and limited chemical complexity. We tested the hypothesis that recombinant DNA and synthetic peptide techniques would make it possible to stimulate vigorous immune responses to specific epitopes of an outer membrane protein of Neisseria gonorrhoeae. The MtrC AP1 sequence from the invariant MtrC gonococcal lipoprotein was genetically fused to maltose binding protein. The resultant fusion protein was used as the primary immunogen to stimulate MtrC AP1-specific antiserum. To enhance antibody production specific to MtrC AP1, boosting immunizations were performed with synthetic MtrC AP1 sequence contained in a multiple antigenic peptide system immunogen. The MtrC AP1-specific antiserum strongly recognized the MtrC protein on Western blots and appeared to bind native MtrC protein in situ. The generation of antibody in this fashion provides the technology to produce antibody to defined epitopes of any protein, including those found in the gonococcal outer membrane. The ability of those antibodies to inhibit bacterial growth or to activate complement protein can then be tested.

  9. Chromosome-specific DNA Repeat Probes

    SciTech Connect

    Baumgartner, Adolf; Weier, Jingly Fung; Weier, Heinz-Ulrich G.

    2006-03-16

    In research as well as in clinical applications, fluorescence in situ hybridization (FISH) has gained increasing popularity as a highly sensitive technique to study cytogenetic changes. Today, hundreds of commercially available DNA probes serve the basic needs of the biomedical research community. Widespread applications, however, are often limited by the lack of appropriately labeled, specific nucleic acid probes. We describe two approaches for an expeditious preparation of chromosome-specific DNAs and the subsequent probe labeling with reporter molecules of choice. The described techniques allow the preparation of highly specific DNA repeat probes suitable for enumeration of chromosomes in interphase cell nuclei or tissue sections. In addition, there is no need for chromosome enrichment by flow cytometry and sorting or molecular cloning. Our PCR-based method uses either bacterial artificial chromosomes or human genomic DNA as templates with {alpha}-satellite-specific primers. Here we demonstrate the production of fluorochrome-labeled DNA repeat probes specific for human chromosomes 17 and 18 in just a few days without the need for highly specialized equipment and without the limitation to only a few fluorochrome labels.

  10. Face recognition: a model specific ability

    PubMed Central

    Wilmer, Jeremy B.; Germine, Laura T.; Nakayama, Ken

    2014-01-01

    In our everyday lives, we view it as a matter of course that different people are good at different things. It can be surprising, in this context, to learn that most of what is known about cognitive ability variation across individuals concerns the broadest of all cognitive abilities; an ability referred to as general intelligence, general mental ability, or just g. In contrast, our knowledge of specific abilities, those that correlate little with g, is severely constrained. Here, we draw upon our experience investigating an exceptionally specific ability, face recognition, to make the case that many specific abilities could easily have been missed. In making this case, we derive key insights from earlier false starts in the measurement of face recognition’s variation across individuals, and we highlight the convergence of factors that enabled the recent discovery that this variation is specific. We propose that the case of face recognition ability illustrates a set of tools and perspectives that could accelerate fruitful work on specific cognitive abilities. By revealing relatively independent dimensions of human ability, such work would enhance our capacity to understand the uniqueness of individual minds. PMID:25346673

  11. Face recognition: a model specific ability.

    PubMed

    Wilmer, Jeremy B; Germine, Laura T; Nakayama, Ken

    2014-01-01

    In our everyday lives, we view it as a matter of course that different people are good at different things. It can be surprising, in this context, to learn that most of what is known about cognitive ability variation across individuals concerns the broadest of all cognitive abilities; an ability referred to as general intelligence, general mental ability, or just g. In contrast, our knowledge of specific abilities, those that correlate little with g, is severely constrained. Here, we draw upon our experience investigating an exceptionally specific ability, face recognition, to make the case that many specific abilities could easily have been missed. In making this case, we derive key insights from earlier false starts in the measurement of face recognition's variation across individuals, and we highlight the convergence of factors that enabled the recent discovery that this variation is specific. We propose that the case of face recognition ability illustrates a set of tools and perspectives that could accelerate fruitful work on specific cognitive abilities. By revealing relatively independent dimensions of human ability, such work would enhance our capacity to understand the uniqueness of individual minds.

  12. Statistical considerations in setting product specifications.

    PubMed

    Dong, Xiaoyu; Tsong, Yi; Shen, Meiyu

    2015-01-01

    According to ICH Q6A (1999), a specification is defined as a list of tests, references to analytical procedures, and appropriate acceptance criteria, which are numerical limits, ranges, or other criteria for the tests described. For drug products, specifications usually consist of test methods and acceptance criteria for assay, impurities, pH, dissolution, moisture, and microbial limits, depending on the dosage forms. They are usually proposed by the manufacturers and subject to the regulatory approval for use. When the acceptance criteria in product specifications cannot be pre-defined based on prior knowledge, the conventional approach is to use data from a limited number of clinical batches during the clinical development phases. Often in time, such acceptance criterion is set as an interval bounded by the sample mean plus and minus two to four standard deviations. This interval may be revised with the accumulated data collected from released batches after drug approval. In this article, we describe and discuss the statistical issues of commonly used approaches in setting or revising specifications (usually tighten the limits), including reference interval, (Min, Max) method, tolerance interval, and confidence limit of percentiles. We also compare their performance in terms of the interval width and the intended coverage. Based on our study results and review experiences, we make some recommendations on how to select the appropriate statistical methods in setting product specifications to better ensure the product quality.

  13. GRB10 imprinting is eutherian mammal specific.

    PubMed

    Stringer, Jessica M; Suzuki, Shunsuke; Pask, Andrew J; Shaw, Geoff; Renfree, Marilyn B

    2012-12-01

    GRB10 is an imprinted gene differently expressed from two promoters in mouse and human. Mouse Grb10 is maternally expressed from the major promoter in most tissues and paternally expressed from the brain-specific promoter within specific regions of the fetal and adult central nervous system. Human GRB10 is biallelically expressed from the major promoter in most tissues except in the placental villus trophoblast where it is maternally expressed, whereas the brain-specific promoter is paternally expressed in the fetal brain. This study characterized the ortholog of GRB10 in a marsupial, the tammar wallaby (Macropus eugenii) to investigate the origin and evolution of imprinting at this locus. The protein coding exons and predicted amino acid sequence of tammar GRB10 were highly conserved with eutherian GRB10. The putative first exon, which is located in the orthologous region to the eutherian major promoter, was found in the tammar, but no exon was found in the downstream region corresponding to the eutherian brain-specific promoter, suggesting that marsupials only have a single promoter. Tammar GRB10 was widely expressed in various tissues including the brain but was not imprinted in any of the tissues examined. Thus, it is likely that GRB10 imprinting evolved in eutherians after the eutherian-marsupial divergence approximately 160 million years ago, subsequent to the acquisition of a brain-specific promoter, which resides within the imprinting control region in eutherians. PMID:22787282

  14. Main factors providing specificity of repair enzymes.

    PubMed

    Nevinsky, G A

    2011-01-01

    Specific and nonspecific DNA complex formation with human uracil-DNA glycosylase, 8-oxoguanine-DNA glycosylase, and apurine/apyrimidine endonuclease, as well as with E. coli 8-oxoguanine-DNA glycosylase and RecA protein was analyzed using the method of stepwise increase in DNA-ligand complexity. It is shown that high affinity of these enzymes to any DNA (10(-4)-10(-8) M) is provided by a large number of weak additive contacts mainly with DNA internucleoside phosphate groups and in a less degree with bases of nucleotide links "covered" by protein globules. Enzyme interactions with specific DNA links are comparable in efficiency with weak unspecific contacts and provide only for one-two orders of affinity (10(-1)-10(-2) M), but these contacts are extremely important at stages of DNA and enzyme structural adaptation and catalysis proper. Only in the case of specific DNA individual for each enzyme alterations in DNA structure provide for efficient adjustment of reacting enzyme atoms and DNA orbitals with accuracy up to 10-15° and, as a result, for high reaction rate. Upon transition from nonspecific to specific DNA, reaction rate (k(cat)) increases by 4-8 orders of magnitude. Thus, stages of DNA and enzyme structural adaptation as well as catalysis proper are the basis of specificity of repair enzymes. PMID:21568843

  15. Face recognition: a model specific ability.

    PubMed

    Wilmer, Jeremy B; Germine, Laura T; Nakayama, Ken

    2014-01-01

    In our everyday lives, we view it as a matter of course that different people are good at different things. It can be surprising, in this context, to learn that most of what is known about cognitive ability variation across individuals concerns the broadest of all cognitive abilities; an ability referred to as general intelligence, general mental ability, or just g. In contrast, our knowledge of specific abilities, those that correlate little with g, is severely constrained. Here, we draw upon our experience investigating an exceptionally specific ability, face recognition, to make the case that many specific abilities could easily have been missed. In making this case, we derive key insights from earlier false starts in the measurement of face recognition's variation across individuals, and we highlight the convergence of factors that enabled the recent discovery that this variation is specific. We propose that the case of face recognition ability illustrates a set of tools and perspectives that could accelerate fruitful work on specific cognitive abilities. By revealing relatively independent dimensions of human ability, such work would enhance our capacity to understand the uniqueness of individual minds. PMID:25346673

  16. Spent nuclear fuel project product specification

    SciTech Connect

    Pajunen, A.L.

    1998-01-30

    Product specifications are limits and controls established for each significant parameter that potentially affects safety and/or quality of the Spent Nuclear Fuel (SNF) packaged for transport to dry storage. The product specifications in this document cover the spent fuel packaged in MultiCanister Overpacks (MCOs) to be transported throughout the SNF Project. The SNF includes N Reactor fuel and single-pass reactor fuel. The FRS removes the SNF from the storage canisters, cleans it, and places it into baskets. The MCO loading system places the baskets into MCO/Cask assembly packages. These packages are then transferred to the Cold Vacuum Drying (CVD) Facility. After drying at the CVD Facility, the MCO cask packages are transferred to the Canister Storage Building (CSB), where the MCOs are removed from the casks, staged, inspected, sealed (by welding), and stored until a suitable permanent disposal option is implemented. The key criteria necessary to achieve these goals are documented in this specification.

  17. Functional specificity of rat vibrissal primary afferents.

    PubMed

    Lucianna, Facundo A; Farfán, Fernando D; Pizá, Gabriel A; Albarracín, Ana L; Felice, Carmelo J

    2016-06-01

    In this study, we propose to analyze the peripheral vibrissal system specificity through its neuronal responses. Receiver operating characteristics (ROC) curve analyses were used, which required the implementation of a binary classifier (artificial neural network) trained to identify the applied stimulus. The training phase consisted of the observation of a predetermined amount of vibrissal sweeps on two surfaces of different texture and similar roughness. Our results suggest that the specificity of the peripheral vibrissal system easily permits the discrimination between perceived stimuli, quantified through neuronal responses, and that it can be evaluated through an ROC curve analysis. We found that such specificity makes a linear binary classifier capable of detecting differences between stimuli with five sweeps at most.

  18. Cell specific, variable density, polymer microspheres

    NASA Technical Reports Server (NTRS)

    Yen, Shiao-Ping S. (Inventor); Rembaum, Alan (Inventor); Molday, Robert S. (Inventor)

    1978-01-01

    Biocompatible polymeric microspheres having an average diameter below about 3 microns and having a density at least 15% greater or lesser than organic cells and having covalent binding sites are provided in accordance with this invention. The microspheres are obtained by copolymerizing a hydroxy or amine substituted acrylic monomer such as hydroxyethylmethacrylate with a light or dense comonomer such as a fluoromonomer. A lectin or antibody is bound to the hydroxy or amine site of the bead to provide cell specificity. When added to a cell suspension the marked bead will specifically label the cell membrane by binding to specific receptor sites thereon. The labelled membrane can then be separated by density gradient centrifugation.

  19. Khoros software specification format and interoperability

    NASA Technical Reports Server (NTRS)

    Rots, A. H.

    1992-01-01

    Khoros defines formats for User Interface Specification (UIS) and Program Specification (PS) files. From such files, its code generator, Ghostwriter, creates source files and documentation. The great advantage of the system is that the code fragments that make up part of the PS file are purely generic. All Khoros-related code is created by the code generator; this includes all user interface code. As a matter of fact, both specification files are very generic in nature. Thus, one could imagine using it as the basis for other software systems. A case is made that writing a code generator that would create IRAF-compatible code from the Khoros UIS and PS files is fairly trivial. Another aspect of the Khoros system conventions concerns the way execution commands are generated by the user interface and the actual syntax of those commands. The protocols are such that interoperability at the level of executable modules is readily possible.

  20. Predictive intervals for age-specific fertility.

    PubMed

    Keilman, N; Pham, D Q

    2000-03-01

    A multivariate ARIMA model is combined with a Gamma curve to predict confidence intervals for age-specific birth rates by 1-year age groups. The method is applied to observed age-specific births in Norway between 1900 and 1995, and predictive intervals are computed for each year up to 2050. The predicted two-thirds confidence intervals for Total Fertility (TF) around 2010 agree well with TF errors in old population forecasts made by Statistics Norway. The method gives useful predictions for age-specific fertility up to the years 2020-30. For later years, the intervals become too wide. Methods that do not take into account estimation errors in the ARIMA model coefficients underestimate the uncertainty for future TF values. The findings suggest that the margin between high and low fertility variants in official population forecasts for many Western countries are too narrow. PMID:12158991

  1. Action-Specific Disruption of Perceptual Confidence

    PubMed Central

    Maniscalco, Brian; Ko, Yoshiaki; Amendi, Namema; Ro, Tony; Lau, Hakwan

    2015-01-01

    Theoretical models of perception assume that confidence is related to the quality or strength of sensory processing. Counter to this intuitive view, we showed in the present research that the motor system also contributes to judgments of perceptual confidence. In two experiments, we used transcranial magnetic stimulation (TMS) to manipulate response-specific representations in the premotor cortex, selectively disrupting postresponse confidence in visual discrimination judgments. Specifically, stimulation of the motor representation associated with the unchosen response reduced confidence in correct responses, thereby reducing metacognitive capacity without changing visual discrimination performance. Effects of TMS on confidence were observed when stimulation was applied both before and after the response occurred, which suggests that confidence depends on late-stage metacognitive processes. These results place constraints on models of perceptual confidence and metacognition by revealing that action-specific information in the premotor cortex contributes to perceptual confidence. PMID:25425059

  2. AWS breaks new ground with soldering specification.

    SciTech Connect

    Vianco, Paul Thomas

    2008-08-01

    Joining technologies continue to advance with new materials, process innovations, and inspection techniques. An increasing number of high-valued, high-reliability applications -- from boilers and ship hulls to rocket motors and medical devices -- have required the development of industry standards and specifications in order to ensure that the best design and manufacturing practices are being used to produce safe, durable products and assemblies. Standards writing has always had an important role at the American Welding Society (AWS). The AWS standards and specifications cover such topics as filler materials, joining processes, inspection techniques, and qualification methods that are used in welding and brazing technologies. These AWS standards and specifications, all of which are approved by the American National Standards Institute (ANSI), have also provided the basis for many similar documents used in Europe and in Pacific Rim countries.

  3. Organelle-Specific Initiation of Autophagy.

    PubMed

    Sica, Valentina; Galluzzi, Lorenzo; Bravo-San Pedro, José Manuel; Izzo, Valentina; Maiuri, Maria Chiara; Kroemer, Guido

    2015-08-20

    Autophagy constitutes a prominent mechanism through which eukaryotic cells preserve homeostasis in baseline conditions and in response to perturbations of the intracellular or extracellular microenvironment. Autophagic responses can be relatively non-selective or target a specific subcellular compartment. At least in part, this depends on the balance between the availability of autophagic substrates ("offer") and the cellular need of autophagic products or functions for adaptation ("demand"). Irrespective of cargo specificity, adaptive autophagy relies on a panel of sensors that detect potentially dangerous cues and convert them into signals that are ultimately relayed to the autophagic machinery. Here, we summarize the molecular systems through which specific subcellular compartments-including the nucleus, mitochondria, plasma membrane, reticular apparatus, and cytosol-convert homeostatic perturbations into an increased offer of autophagic substrates or an accrued cellular demand for autophagic products or functions. PMID:26295960

  4. Embryonic stem cell neurogenesis and neural specification.

    PubMed

    Germain, Noélle; Banda, Erin; Grabel, Laura

    2010-10-15

    The prospect of using embryonic stem cell (ESC)-derived neural progenitors and neurons to treat neurological disorders has led to great interest in defining the conditions that guide the differentiation of ESCs, and more recently induced pluripotent stem cells (iPSCs), into neural stem cells (NSCs) and a variety of neuronal and glial subtypes. Over the past decade, researchers have looked to the embryo to guide these studies, applying what we know about the signaling events that direct neural specification during development. This has led to the design of a number of protocols that successfully promote ESC neurogenesis, terminating with the production of neurons and glia with diverse regional addresses and functional properties. These protocols demonstrate that ESCs undergo neural specification in two, three, and four dimensions, mimicking the cell-cell interactions, patterning, and timing that characterizes the in vivo process. We therefore propose that these in vitro systems can be used to examine the molecular regulation of neural specification.

  5. Action goals influence action-specific perception.

    PubMed

    Cañal-Bruland, Rouwen; van der Kamp, John

    2009-12-01

    We examined the processes that mediate the emergence of action-specific influences on perception that have recently been reported for baseball batting and golf putting (Witt, Linkenauger, Bakdash, & Proffitt, 2008; Witt & Proffitt, 2005). To this end, we used a Schokokusswurfmaschine: Children threw a ball at a target, which, if hit successfully, launched a ball that the children then had to catch. In two experiments, children performed either a throwing-and-catching task or a throwing-only task, in which no ball was launched. After each task, the size of the target or of the ball was estimated. Results indicate that action-specific influences on perceived size occur for objects that are related to the end goal of the action, but not for objects that are related to intermediate action goals. These results suggest that action-specific influences on perception are contingent upon the primary action goals to be achieved.

  6. Specificity and stereospecificity of α-chymotrypsin

    PubMed Central

    Ingles, D. W.; Knowles, J. R.

    1967-01-01

    1. The optically pure p-nitrophenyl esters of the d and l enantiomers of N-acetyl-tryptophan, N-acetylphenylalanine and N-acetyl-leucine, and the p-nitrophenyl ester of N-acetylglycine, have been prepared. 2. These materials are all substrates of α-chymotrypsin, and the rates of deacylation of the corresponding acyl-α-chymotrypsins have been determined. 3. As the size of the amino acid side chain increases, the l series deacylate progressively faster than the N-acetylglycyl-enzyme, and the d series progressively more slowly. 4. The results are interpreted in terms of a three-locus model of the enzyme's active site, which accounts for the interrelationship between substrate specificity and stereospecificity observed. 5. The concepts of negative specificity and of specificity saturation are introduced. PMID:6048779

  7. Eosinophilic prostatitis and prostatic specific antigen.

    PubMed

    Liu, S; Miller, P D; Holmes, S A; Christmas, T J; Kirby, R S

    1992-01-01

    Eosinophilic prostatitis is a rare form of abacterial prostatitis with uncertain aetiology. Its clinical presentation, like other types of abacterial prostatitis, commonly mimics carcinoma of the prostate. Transrectal ultrasound may be helpful in the diagnosis of prostatitis but histological confirmation is necessary. Prostatic specific antigen has been widely used in the diagnosis and follow-up of patients with prostatic carcinoma. High levels of this antigen (greater than 30 micrograms/l) have been claimed to be highly specific for prostate cancer, although lesser elevations may also occur in patients with large benign prostate glands and in bacterial prostatitis. We report 3 patients with histologically proven eosinophilic prostatitis and high levels of prostatic specific antigen. This diagnosis may closely mimic carcinoma of the prostate and must be excluded by histological examination of biopsy material before treatment for presumed prostate carcinoma is initiated.

  8. ROC analysis in patient specific quality assurance

    SciTech Connect

    Carlone, Marco; MacPherson, Miller; Cruje, Charmainne; Rangel, Alejandra; McCabe, Ryan; Nielsen, Michelle

    2013-04-15

    Purpose: This work investigates the use of receiver operating characteristic (ROC) methods in patient specific IMRT quality assurance (QA) in order to determine unbiased methods to set threshold criteria for {gamma}-distance to agreement measurements. Methods: A group of 17 prostate plans was delivered as planned while a second group of 17 prostate plans was modified with the introduction of random multileaf collimator (MLC) position errors that are normally distributed with {sigma}{approx}{+-}0.5, {+-}1.0, {+-}2.0, and {+-}3.0 mm (a total of 68 modified plans were created). All plans were evaluated using five different {gamma}-criteria. ROC methodology was applied by quantifying the fraction of modified plans reported as 'fail' and unmodified plans reported as 'pass.'Results: {gamma}-based criteria were able to attain nearly 100% sensitivity/specificity in the detection of large random errors ({sigma} > 3 mm). Sensitivity and specificity decrease rapidly for all {gamma}-criteria as the size of error to be detected decreases below 2 mm. Predictive power is null with all criteria used in the detection of small MLC errors ({sigma} < 0.5 mm). Optimal threshold values were established by determining which criteria maximized sensitivity and specificity. For 3%/3 mm {gamma}-criteria, optimal threshold values range from 92% to 99%, whereas for 2%/2 mm, the range was from 77% to 94%. Conclusions: The optimal threshold values that were determined represent a maximized test sensitivity and specificity and are not subject to any user bias. When applied to the datasets that we studied, our results suggest the use of patient specific QA as a safety tool that can effectively prevent large errors (e.g., {sigma} > 3 mm) as opposed to a tool to improve the quality of IMRT delivery.

  9. Assessing Specificity of Anticancer Drugs In Vitro

    PubMed Central

    Kluwe, Lan

    2016-01-01

    A procedure for assessing specificity of anticancer drugs in vitro using cultures containing both tumor and non-tumor cells is demonstrated. The key element is the quantitative determination of a tumor-specific genetic alteration in relation to a universal sequence using a dual-probe digital PCR assay and the subsequent calculation of the proportion of tumor cells. The assay is carried out on a culture containing tumor cells of an established line and spiked-in non-tumor cells. The mixed culture is treated with a test drug at various concentrations. After the treatment, DNA is prepared directly from the survived adhesive cells in wells of 96-well plates using a simple and inexpensive method, and subjected to a dual-probe digital PCR assay for measuring a tumor-specific genetic alteration and a reference universal sequence. In the present demonstration, a heterozygous deletion of the NF1 gene is used as the tumor-specific genetic alteration and a RPP30 gene as the reference gene. Using the ratio NF1/RPP30, the proportion of tumor cells was calculated. Since the dose-dependent change of the proportion of tumor cells provides an in vitro indication for specificity of the drug, this genetic and cell-based in vitro assay will likely have application potential in drug discovery. Furthermore, for personalized cancer-care, this genetic- and cell-based tool may contribute to optimizing adjuvant chemotherapy by means of testing efficacy and specificity of candidate drugs using primary cultures of individual tumors. PMID:27078035

  10. DOE site-specific threat assessment

    SciTech Connect

    West, D.J.; Al-Ayat, R.A.; Judd, B.R.

    1985-07-12

    A facility manager faced with the challenges of protecting a nuclear facility against potential threats must consider the likelihood and consequences of such threats, know the capabilities of the facility safeguards and security systems, and make informed decisions about the cost-effectivness of safeguards and security upgrades. To help meet these challenges, the San Francisco Operations Office of the Department of Energy, in conjunction with the Lawrence Livermore Laboratory, has developed a site-specific threat assessment approach and a quantitative model to improve the quality and consistency of site-specific threat assessment and resultant security upgrade decisions at sensitive Department of Energy facilities. 5 figs.

  11. Molecular specific optoacoustic imaging with plasmonic nanoparticles

    NASA Astrophysics Data System (ADS)

    Mallidi, Srivalleesha; Larson, Timothy; Aaron, Jesse; Sokolov, Konstantin; Emelianov, Stanislav

    2007-05-01

    Gold nanoparticles functionalized with antibodies can specifically bind to molecular biomarkers such as epithelial growth factor receptor (EGFR). The molecule specific nature of the antibody-functionalized gold nanoparticles forms the basis for the developed optoacoustic imaging technique to detect cancer at an asymptotic stage. Optoacoustic imaging was performed with 532 nm and 680 nm pulsed laser irradiation on three-dimensional tissue phantoms prepared using a human keratinocyte cell line. The results of our study demonstrate that the combination of anti-EGFR gold ioconjugates and optoacoustic imaging can allow highly sensitive and selective detection of human epithelial cancer cells.

  12. [Development of domain specific search engines].

    PubMed

    Takai, T; Tokunaga, M; Maeda, K; Kaminuma, T

    2000-01-01

    As cyber space exploding in a pace that nobody has ever imagined, it becomes very important to search cyber space efficiently and effectively. One solution to this problem is search engines. Already a lot of commercial search engines have been put on the market. However these search engines respond with such cumbersome results that domain specific experts can not tolerate. Using a dedicate hardware and a commercial software called OpenText, we have tried to develop several domain specific search engines. These engines are for our institute's Web contents, drugs, chemical safety, endocrine disruptors, and emergent response for chemical hazard. These engines have been on our Web site for testing.

  13. Spent Nuclear Fuel (SNF) Project Product Specification

    SciTech Connect

    PAJUNEN, A.L.

    2000-12-07

    The process for removal of Spent Nuclear Fuel (SNF) from the K Basins has been divided into major sub-systems. The Fuel Retrieval System (FRS) removes fuel from the existing storage canisters, cleans it, and places it into baskets. The multi-canister overpack (MCO) loading system places the baskets into an MCO that has been pre-loaded in a cask. The cask, containing a loaded MCO, is then transferred to the Cold Vacuum Drying (CVD) Facility. After drying at the CVD Facility, the cask, and MCO, are transferred to the Canister Storage Building (CSB), where the MCO is removed from the cask, staged, inspected, sealed (by welding), and stored until a suitable permanent disposal option is implemented. The purpose of this document is to specify the process related characteristics of an MCO at the interface between major process systems. The characteristics are derived from the primary technical documents that form the basis for safety analysis and design calculations. This document translates the calculation assumptions into implementation requirements and describes the method of verifying that the requirement is achieved. These requirements are used to define validation test requirements and describe requirements that influence multiple sub-project safety analysis reports. This product specification establishes limits and controls for each significant process parameter at interfaces between major sub-systems that potentially affect the overall safety and/or quality of the SNF packaged for processing, transport, and interim dry storage. The product specifications in this document cover the SNF packaged in MCOs to be transported throughout the SNF Project. The description of the product specifications are organized in the document as follows: Section 2.0--Summary listing of product specifications at each major sub-system interface. Section 3.0--Summary description providing guidance as to how specifications are complied with by equipment design or processing within a major

  14. Site-Specific Infrared Probes of Proteins

    PubMed Central

    Ma, Jianqiang; Pazos, Ileana M.; Zhang, Wenkai; Culik, Robert M.; Gai, Feng

    2015-01-01

    Infrared spectroscopy has played an instrumental role in studying a wide variety of biological questions. However, in many cases it is impossible or difficult to rely on the intrinsic vibrational modes of biological molecules of interest, such as proteins, to reveal structural and/or environmental information in a site-specific manner. To overcome this limitation, many recent efforts have been dedicated to the development and application of various extrinsic vibrational probes that can be incorporated into biological molecules and used to site-specifically interrogate their structural and/or environmental properties. In this Review, we highlight some recent advancements of this rapidly growing research area. PMID:25580624

  15. Nutrient-Specific Foraging in Invertebrate Predators

    NASA Astrophysics Data System (ADS)

    Mayntz, David; Raubenheimer, David; Salomon, Mor; Toft, Søren; Simpson, Stephen J.

    2005-01-01

    Many herbivores and omnivores adjust their food selection behavior to regulate the intake of multiple nutrients. Carnivores, however, are generally assumed to optimize the rate of prey capture rather than select prey according to nutrient composition. We showed experimentally that invertebrate predators can forage selectively for protein and lipids to redress specific nutritional imbalances. This selection can take place at different stages of prey handling: The predator may select among foods of different nutritional composition, eat more of a prey if it is rich in nutrients that the predator is deficient in, or extract specific nutrients from a single prey item.

  16. Specific optical rotation indicatrices of chitosan films

    NASA Astrophysics Data System (ADS)

    Rudenko, Darya A.; Shipovskaya, Anna B.

    2016-04-01

    The optical activity of chitosan films in the forms of polysalt (chitosan acetate) and polybase was studied. The specific optical rotation [α] of all our films was negative. The absolute values of [α] of polybasic chitosan films was by an order of magnitude higher than that for polysalt films. A dependence of [α] on the orientation angle of the sample relative to the direction of the polarization vector of the incident light beam in the plane perpendicular to this beam was established. Specific optical rotation indicatrices of the chitosan films of both chemical forms were plotted.

  17. Engineered waste-package-system design specification

    SciTech Connect

    Not Available

    1983-05-01

    This report documents the waste package performance requirements and geologic and waste form data bases used in developing the conceptual designs for waste packages for salt, tuff, and basalt geologies. The data base reflects the latest geotechnical information on the geologic media of interest. The parameters or characteristics specified primarily cover spent fuel, defense high-level waste, and commercial high-level waste forms. The specification documents the direction taken during the conceptual design activity. A separate design specification will be developed prior to the start of the preliminary design activity.

  18. Interactive specification acquisition via scenarios: A proposal

    NASA Technical Reports Server (NTRS)

    Hall, Robert J.

    1992-01-01

    Some reactive systems are most naturally specified by giving large collections of behavior scenarios. These collections not only specify the behavior of the system, but also provide good test suites for validating the implemented system. Due to the complexity of the systems and the number of scenarios, however, it appears that automated assistance is necessary to make this software development process workable. Interactive Specification Acquisition Tool (ISAT) is a proposed interactive system for supporting the acquisition and maintenance of a formal system specification from scenarios, as well as automatic synthesis of control code and automated test generation. This paper discusses the background, motivation, proposed functions, and implementation status of ISAT.

  19. Nutrient-specific foraging in invertebrate predators.

    PubMed

    Mayntz, David; Raubenheimer, David; Salomon, Mor; Toft, Søren; Simpson, Stephen J

    2005-01-01

    Many herbivores and omnivores adjust their food selection behavior to regulate the intake of multiple nutrients. Carnivores, however, are generally assumed to optimize the rate of prey capture rather than select prey according to nutrient composition. We showed experimentally that invertebrate predators can forage selectively for protein and lipids to redress specific nutritional imbalances. This selection can take place at different stages of prey handling: The predator may select among foods of different nutritional composition, eat more of a prey if it is rich in nutrients that the predator is deficient in, or extract specific nutrients from a single prey item.

  20. Software engineering with application-specific languages

    NASA Technical Reports Server (NTRS)

    Campbell, David J.; Barker, Linda; Mitchell, Deborah; Pollack, Robert H.

    1993-01-01

    Application-Specific Languages (ASL's) are small, special-purpose languages that are targeted to solve a specific class of problems. Using ASL's on software development projects can provide considerable cost savings, reduce risk, and enhance quality and reliability. ASL's provide a platform for reuse within a project or across many projects and enable less-experienced programmers to tap into the expertise of application-area experts. ASL's have been used on several software development projects for the Space Shuttle Program. On these projects, the use of ASL's resulted in considerable cost savings over conventional development techniques. Two of these projects are described.

  1. Especial skills: specificity embedded within generality.

    PubMed

    Keetch, Katherine M; Lee, Timothy D; Schmidt, Richard A

    2008-12-01

    Recent evidence suggests that massive amounts of practice of the basketball free throw (a "set shot") results in the development of a specific memory representation that is unique to this one shot distance and angle, and that is distinct from set shots taken at locations other than the free throw line. We termed this unique capability an especial skill. In this article, we review the evidence and provide new data regarding the existence of especial skills. These findings are discussed in terms of their implications for motor control theory and in terms of the broader context of specificity versus generality in the learning of motor skills.

  2. 31 CFR 536.313 - Specific license.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Specific license. 536.313 Section 536.313 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY NARCOTICS TRAFFICKING SANCTIONS REGULATIONS...

  3. 31 CFR 536.313 - Specific license.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Specific license. 536.313 Section 536.313 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY NARCOTICS TRAFFICKING SANCTIONS REGULATIONS...

  4. 31 CFR 536.313 - Specific license.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Specific license. 536.313 Section 536.313 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY NARCOTICS TRAFFICKING SANCTIONS REGULATIONS...

  5. 31 CFR 536.313 - Specific license.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Specific license. 536.313 Section 536.313 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY NARCOTICS TRAFFICKING SANCTIONS REGULATIONS...

  6. 31 CFR 536.313 - Specific license.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Specific license. 536.313 Section 536.313 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY NARCOTICS TRAFFICKING SANCTIONS REGULATIONS...

  7. Justifying group-specific common morality.

    PubMed

    Strong, Carson

    2008-01-01

    Some defenders of the view that there is a common morality have conceived such morality as being universal, in the sense of extending across all cultures and times. Those who deny the existence of such a common morality often argue that the universality claim is implausible. Defense of common morality must take account of the distinction between descriptive and normative claims that there is a common morality. This essay considers these claims separately and identifies the nature of the arguments for each claim. It argues that the claim that there is a universal common morality in the descriptive sense has not been successfully defended to date. It maintains that the claim that there is a common morality in the normative sense need not be understood as universalist. This paper advocates the concept of group specific common morality, including country-specific versions. It suggests that both the descriptive and the normative claims that there are country-specific common moralities are plausible, and that a country-specific normative common morality could provide the basis for a country's bioethics.

  8. Teacher's Corner: Conducting Specification Searches with Amos

    ERIC Educational Resources Information Center

    Schumacker, Randall E.

    2006-01-01

    Amos 5.0 (Arbuckle, 2003) permits exploratory specification searches for the best theoretical model given an initial model using the following fit function criteria: chi-square (C), chi-square--df (C--df), Akaike Information Criteria (AIC), Browne-Cudeck criterion (BCC), Bayes Information Criterion (BIC) , chi-square divided by the degrees of…

  9. 18 CFR 1301.24 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Specific exemptions. 1301.24 Section 1301.24 Conservation of Power and Water Resources TENNESSEE VALLEY AUTHORITY PROCEDURES... existence or scope of investigations, lead to suppression, alteration, fabrication, or destruction...

  10. 10 CFR 62.5 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Specific exemptions. 62.5 Section 62.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CRITERIA AND PROCEDURES FOR EMERGENCY ACCESS TO NON-FEDERAL AND REGIONAL... or property or the common defense and security and is otherwise in the public interest....

  11. 10 CFR 11.9 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Specific exemptions. 11.9 Section 11.9 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO OR CONTROL OVER... granted only if they are authorized by law and will not constitute an undue risk to the common defense...

  12. Public Address Systems. Specifications - Installation - Operation.

    ERIC Educational Resources Information Center

    Palmer, Fred M.

    Provisions for public address in new construction of campus buildings (specifications, installations, and operation of public address systems), are discussed in non-technical terms. Consideration is given to microphones, amplifiers, loudspeakers and the placement and operation of various different combinations. (FS)

  13. Measuring Language-Specific Phonetic Settings

    ERIC Educational Resources Information Center

    Mennen, Ineke; Scobbie, James M.; de Leeuw, Esther; Schaeffler, Sonja; Schaeffler, Felix

    2010-01-01

    While it is well known that languages have different phonemes and phonologies, there is growing interest in the idea that languages may also differ in their "phonetic setting". The term "phonetic setting" refers to a tendency to make the vocal apparatus employ a language-specific habitual configuration. For example, languages may differ in their…

  14. Ribosomopathies: Global process, tissue specific defects

    PubMed Central

    Yelick, Pamela C; Trainor, Paul A

    2015-01-01

    Disruptions in ribosomal biogenesis would be expected to have global and in fact lethal effects on a developing organism. However, mutations in ribosomal protein genes have been shown in to exhibit tissue specific defects. This seemingly contradictory finding - that globally expressed genes thought to play fundamental housekeeping functions can in fact exhibit tissue and cell type specific functions ‐ provides new insight into roles for ribosomes, the protein translational machinery of the cell, in regulating normal development and disease. Furthermore it illustrates the surprisingly dynamic nature of processes regulating cell type specific protein translation. In this review, we discuss our current knowledge of a variety of ribosomal protein mutations associated with human disease, and models to better understand the molecular mechanisms associated with each. We use specific examples to emphasize both the similarities and differences between the effects of various human ribosomal protein mutations. Finally, we discuss areas of future study that are needed to further our understanding of the role of ribosome biogenesis in normal development, and possible approaches that can be used to treat debilitating ribosomopathy diseases. PMID:26442198

  15. Sense and specificity in neuronal calcium signalling☆

    PubMed Central

    Burgoyne, Robert D.; Haynes, Lee P.

    2015-01-01

    Changes in the intracellular free calcium concentration ([Ca2 +]i) in neurons regulate many and varied aspects of neuronal function over time scales from microseconds to days. The mystery is how a single signalling ion can lead to such diverse and specific changes in cell function. This is partly due to aspects of the Ca2 + signal itself, including its magnitude, duration, localisation and persistent or oscillatory nature. The transduction of the Ca2 + signal requires Ca2 + binding to various Ca2 + sensor proteins. The different properties of these sensors are important for differential signal processing and determine the physiological specificity of Ca2 + signalling pathways. A major factor underlying the specific roles of particular Ca2 + sensor proteins is the nature of their interaction with target proteins and how this mediates unique patterns of regulation. We review here recent progress from structural analyses and from functional analyses in model organisms that have begun to reveal the rules that underlie Ca2 + sensor protein specificity for target interaction. We discuss three case studies exemplifying different aspects of Ca2 + sensor/target interaction. This article is part of a special issue titled the 13th European Symposium on Calcium. PMID:25447549

  16. Specific Approaches to Health Effects of Pollutants

    ERIC Educational Resources Information Center

    Lee, Douglas H. K.

    1973-01-01

    Briefly describes the current knowledge about the effects of environmental agents on man, and specifically outlines the action of a number of pollutants in the human body. Suggests guidelines for national and international action during the next decade to increase knowledge and understanding in this area. (JR)

  17. 32 CFR 1901.63 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Specific exemptions. 1901.63 Section 1901.63 National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY PUBLIC RIGHTS... section (k) of the Privacy Act, the Director of Central Intelligence has determined to exempt from...

  18. 32 CFR 1901.63 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Specific exemptions. 1901.63 Section 1901.63 National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY PUBLIC RIGHTS... section (k) of the Privacy Act, the Director of Central Intelligence has determined to exempt from...

  19. 32 CFR 1901.63 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 6 2014-07-01 2014-07-01 false Specific exemptions. 1901.63 Section 1901.63 National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY PUBLIC RIGHTS... section (k) of the Privacy Act, the Director of Central Intelligence has determined to exempt from...

  20. 32 CFR 1901.63 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 6 2012-07-01 2012-07-01 false Specific exemptions. 1901.63 Section 1901.63 National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY PUBLIC RIGHTS... section (k) of the Privacy Act, the Director of Central Intelligence has determined to exempt from...

  1. 32 CFR 1901.63 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Specific exemptions. 1901.63 Section 1901.63 National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY PUBLIC RIGHTS... section (k) of the Privacy Act, the Director of Central Intelligence has determined to exempt from...

  2. Model Educational Specifications for Technology in Schools.

    ERIC Educational Resources Information Center

    Maryland State Dept. of Education, College Park. Office of Administration and Finance.

    This description of the Model Edspec, which can be used by itself or in conjunction with the "Format Guide of Educational Specifications," serves as a comprehensive planning tool for the selection and application of technology. The model is designed to assist schools in implementing the facilities development process, thereby making electronic…

  3. Evaluation of the Learning Path Specification

    ERIC Educational Resources Information Center

    Janssen, Jose; Berlanga, Adriana J.; Koper, Rob

    2011-01-01

    Flexible lifelong learning requires that learners can compare and select learning paths that best meet individual needs, not just in terms of learning goals, but also in terms of planning, costs etc. To this end a learning path specification was developed, which describes both the contents and the structure of any learning path, be it formal,…

  4. 46 CFR 172.047 - Specific applicability.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Specific applicability. 172.047 Section 172.047 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO BULK CARGOES Special Rules Pertaining to a Barge That Carries a Cargo Regulated Under Subchapter D of This Chapter § 172.047...

  5. 46 CFR 172.047 - Specific applicability.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Specific applicability. 172.047 Section 172.047 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO BULK CARGOES Special Rules Pertaining to a Barge That Carries a Cargo Regulated Under Subchapter D of This Chapter § 172.047...

  6. Video in English for Specific Purposes.

    ERIC Educational Resources Information Center

    Hristova, Rozinka

    For an English for Specific Purposes (ESP) course to be efficient, the learner and his/her communicative needs should be central in deciding course content and activities. Video can be highly motivating by presenting live instances of communication in the target environment. It is a valuable medium for intensive analysis of visual and nonverbal…

  7. 10 CFR 54.15 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Specific exemptions. 54.15 Section 54.15 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) REQUIREMENTS FOR RENEWAL OF OPERATING LICENSES FOR NUCLEAR POWER PLANTS... granted by the Commission in accordance with 10 CFR 50.12....

  8. 10 CFR 54.15 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Specific exemptions. 54.15 Section 54.15 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) REQUIREMENTS FOR RENEWAL OF OPERATING LICENSES FOR NUCLEAR POWER PLANTS... granted by the Commission in accordance with 10 CFR 50.12....

  9. 10 CFR 54.15 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Specific exemptions. 54.15 Section 54.15 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) REQUIREMENTS FOR RENEWAL OF OPERATING LICENSES FOR NUCLEAR POWER PLANTS... granted by the Commission in accordance with 10 CFR 50.12....

  10. 10 CFR 54.15 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Specific exemptions. 54.15 Section 54.15 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) REQUIREMENTS FOR RENEWAL OF OPERATING LICENSES FOR NUCLEAR POWER PLANTS... granted by the Commission in accordance with 10 CFR 50.12....

  11. 10 CFR 54.15 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Specific exemptions. 54.15 Section 54.15 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) REQUIREMENTS FOR RENEWAL OF OPERATING LICENSES FOR NUCLEAR POWER PLANTS... granted by the Commission in accordance with 10 CFR 50.12....

  12. 50 CFR 648.162 - Bluefish specifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Bluefish specifications. 648.162 Section 648.162 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE FISHERIES OF THE NORTHEASTERN UNITED STATES Management Measures for the Atlantic Bluefish Fishery §...

  13. Ultrahigh Specific Impulse Nuclear Thermal Propulsion

    SciTech Connect

    Anne Charmeau; Brandon Cunningham; Samim Anghaie

    2009-02-09

    Research on nuclear thermal propulsion systems (NTP) have been in forefront of the space nuclear power and propulsion due to their design simplicity and their promise for providing very high thrust at reasonably high specific impulse. During NERVA-ROVER program in late 1950's till early 1970's, the United States developed and ground tested about 18 NTP systems without ever deploying them into space. The NERVA-ROVER program included development and testing of NTP systems with very high thrust (~250,000 lbf) and relatively high specific impulse (~850 s). High thrust to weight ratio in NTP systems is an indicator of high acceleration that could be achieved with these systems. The specific impulse in the lowest mass propellant, hydrogen, is a function of square root of absolute temperature in the NTP thrust chamber. Therefor optimizing design performance of NTP systems would require achieving the highest possible hydrogen temperature at reasonably high thrust to weight ratio. High hydrogen exit temperature produces high specific impulse that is a diret measure of propellant usage efficiency.

  14. Ultrasonic hydrometer. [Specific gravity of electrolyte

    DOEpatents

    Swoboda, C.A.

    1982-03-09

    The disclosed ultrasonic hydrometer determines the specific gravity (density) of the electrolyte of a wet battery, such as a lead-acid battery. The hydrometer utilizes a transducer that when excited emits an ultrasonic impulse that traverses through the electrolyte back and forth between spaced sonic surfaces. The transducer detects the returning impulse, and means measures the time t between the initial and returning impulses. Considering the distance d between the spaced sonic surfaces and the measured time t, the sonic velocity V is calculated with the equation V = 2d/t. The hydrometer also utilizes a thermocouple to measure the electrolyte temperature. A hydrometer database correlates three variable parameters including sonic velocity in and temperature and specific gravity of the electrolyte, for temperature values between 0 and 40/sup 0/C and for specific gravity values between 1.05 and 1.30. Upon knowing two parameters (the calculated sonic velocity and the measured temperature), the third parameter (specific gravity) can be uniquely found in the database. The hydrometer utilizes a microprocessor for data storage and manipulation.

  15. Side-Specific Reward Memories in Honeybees

    ERIC Educational Resources Information Center

    Gil, Mariana; Menzel, Randolf; De Marco, Rodrigo J.

    2009-01-01

    We report a hitherto unknown form of side-specific learning in honeybees. We trained bees individually by coupling gustatory and mechanical stimulation of each antenna with either increasing or decreasing volumes of sucrose solution offered to the animal's proboscis along successive learning trials. Next, we examined their proboscis extension…

  16. 76 FR 30551 - Specifications for Packagings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-26

    ... Pipeline and Hazardous Materials Safety Administration 49 CFR Part 178 Specifications for Packagings CFR... on a packaging, a test report must be prepared. The test report must be maintained at each location where the packaging is manufactured and each location where the design qualification tests are...

  17. 31 CFR 596.309 - Specific license.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Specific license. 596.309 Section 596.309 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY TERRORISM LIST GOVERNMENTS SANCTIONS...

  18. 31 CFR 596.309 - Specific license.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Specific license. 596.309 Section 596.309 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY TERRORISM LIST GOVERNMENTS SANCTIONS...

  19. 31 CFR 596.309 - Specific license.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Specific license. 596.309 Section 596.309 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY TERRORISM LIST GOVERNMENTS SANCTIONS...

  20. 31 CFR 596.309 - Specific license.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Specific license. 596.309 Section 596.309 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY TERRORISM LIST GOVERNMENTS SANCTIONS...

  1. 31 CFR 596.309 - Specific license.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Specific license. 596.309 Section 596.309 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY TERRORISM LIST GOVERNMENTS SANCTIONS...

  2. Isotope specific arbitrary material flow meter

    DOEpatents

    Barty, Christopher P. J.; Post, John C.; Jones, Edwin

    2016-10-25

    A laser-based mono-energetic gamma-ray source is used to provide non-destructive and non-intrusive, quantitative determination of the absolute amount of a specific isotope contained within pipe as part of a moving fluid or quasi-fluid material stream.

  3. Alteration of substrate specificity of alanine dehydrogenase

    PubMed Central

    Fernandes, Puja; Aldeborgh, Hannah; Carlucci, Lauren; Walsh, Lauren; Wasserman, Jordan; Zhou, Edward; Lefurgy, Scott T.; Mundorff, Emily C.

    2015-01-01

    The l-alanine dehydrogenase (AlaDH) has a natural history that suggests it would not be a promising candidate for expansion of substrate specificity by protein engineering: it is the only amino acid dehydrogenase in its fold family, it has no sequence or structural similarity to any known amino acid dehydrogenase, and it has a strong preference for l-alanine over all other substrates. By contrast, engineering of the amino acid dehydrogenase superfamily members has produced catalysts with expanded substrate specificity; yet, this enzyme family already contains members that accept a broad range of substrates. To test whether the natural history of an enzyme is a predictor of its innate evolvability, directed evolution was carried out on AlaDH. A single mutation identified through molecular modeling, F94S, introduced into the AlaDH from Mycobacterium tuberculosis (MtAlaDH) completely alters its substrate specificity pattern, enabling activity toward a range of larger amino acids. Saturation mutagenesis libraries in this mutant background additionally identified a double mutant (F94S/Y117L) showing improved activity toward hydrophobic amino acids. The catalytic efficiencies achieved in AlaDH are comparable with those that resulted from similar efforts in the amino acid dehydrogenase superfamily and demonstrate the evolvability of MtAlaDH specificity toward other amino acid substrates. PMID:25538307

  4. The Specific Analysis of Structural Equation Models

    ERIC Educational Resources Information Center

    McDonald, Roderick P.

    2004-01-01

    Conventional structural equation modeling fits a covariance structure implied by the equations of the model. This treatment of the model often gives misleading results because overall goodness of fit tests do not focus on the specific constraints implied by the model. An alternative treatment arising from Pearl's directed acyclic graph theory…

  5. 32 CFR 319.13 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PROGRAM DEFENSE INTELLIGENCE AGENCY PRIVACY PROGRAM § 319.13 Specific exemptions. (a) All systems of records maintained by the Director Intelligence Agency shall be exempt from the requirements of 5 U.S.C... has been properly classified. (b) The Director, Defense Intelligence Agency, designated the systems...

  6. 32 CFR 319.13 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... PROGRAM DEFENSE INTELLIGENCE AGENCY PRIVACY PROGRAM § 319.13 Specific exemptions. (a) All systems of records maintained by the Director Intelligence Agency shall be exempt from the requirements of 5 U.S.C... has been properly classified. (b) The Director, Defense Intelligence Agency, designated the systems...

  7. Patient-specific models of cardiac biomechanics

    NASA Astrophysics Data System (ADS)

    Krishnamurthy, Adarsh; Villongco, Christopher T.; Chuang, Joyce; Frank, Lawrence R.; Nigam, Vishal; Belezzuoli, Ernest; Stark, Paul; Krummen, David E.; Narayan, Sanjiv; Omens, Jeffrey H.; McCulloch, Andrew D.; Kerckhoffs, Roy C. P.

    2013-07-01

    Patient-specific models of cardiac function have the potential to improve diagnosis and management of heart disease by integrating medical images with heterogeneous clinical measurements subject to constraints imposed by physical first principles and prior experimental knowledge. We describe new methods for creating three-dimensional patient-specific models of ventricular biomechanics in the failing heart. Three-dimensional bi-ventricular geometry is segmented from cardiac CT images at end-diastole from patients with heart failure. Human myofiber and sheet architecture is modeled using eigenvectors computed from diffusion tensor MR images from an isolated, fixed human organ-donor heart and transformed to the patient-specific geometric model using large deformation diffeomorphic mapping. Semi-automated methods were developed for optimizing the passive material properties while simultaneously computing the unloaded reference geometry of the ventricles for stress analysis. Material properties of active cardiac muscle contraction were optimized to match ventricular pressures measured by cardiac catheterization, and parameters of a lumped-parameter closed-loop model of the circulation were estimated with a circulatory adaptation algorithm making use of information derived from echocardiography. These components were then integrated to create a multi-scale model of the patient-specific heart. These methods were tested in five heart failure patients from the San Diego Veteran's Affairs Medical Center who gave informed consent. The simulation results showed good agreement with measured echocardiographic and global functional parameters such as ejection fraction and peak cavity pressures.

  8. 50 CFR 660.709 - Annual specifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Annual specifications. 660.709 Section 660.709 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES OFF WEST COAST STATES Highly Migratory...

  9. Diamond Drilling Specification Manual and Course Outline.

    ERIC Educational Resources Information Center

    British Columbia Dept. of Education, Victoria.

    This publication presents the standards required of a person practicing diamond drilling in western Canada and provides an outline for teaching the skills and knowledge. It is divided into two parts. The Diamond Drilling Specification Manual establishes the levels of skill and knowledge required in the four certified levels of diamond drilling.…

  10. Specification of the somatic musculature in Drosophila.

    PubMed

    Dobi, Krista C; Schulman, Victoria K; Baylies, Mary K

    2015-01-01

    The somatic muscle system formed during Drosophila embryogenesis is required for larvae to hatch, feed, and crawl. This system is replaced in the pupa by a new adult muscle set, responsible for activities such as feeding, walking, and flight. Both the larval and adult muscle systems are comprised of distinct muscle fibers to serve these specific motor functions. In this way, the Drosophila musculature is a valuable model for patterning within a single tissue: while all muscle cells share properties such as the contractile apparatus, properties such as size, position, and number of nuclei are unique for a particular muscle. In the embryo, diversification of muscle fibers relies first on signaling cascades that pattern the mesoderm. Subsequently, the combinatorial expression of specific transcription factors leads muscle fibers to adopt particular sizes, shapes, and orientations. Adult muscle precursors (AMPs), set aside during embryonic development, proliferate during the larval phases and seed the formation of the abdominal, leg, and flight muscles in the adult fly. Adult muscle fibers may either be formed de novo from the fusion of the AMPs, or are created by the binding of AMPs to an existing larval muscle. While less is known about adult muscle specification compared to the larva, expression of specific transcription factors is also important for its diversification. Increasingly, the mechanisms required for the diversification of fly muscle have found parallels in vertebrate systems and mark Drosophila as a robust model system to examine questions about how diverse cell types are generated within an organism.

  11. Removing the Barriers: Accessibility Guidelines and Specifications.

    ERIC Educational Resources Information Center

    Cotler, Stephen R.

    This guide provides guidelines for meeting the accessibility requirements of the Americans with Disabilities (ADA) Act in college and university buildings. The publication is divided into 10 chapters, the first 7 of which present construction drawings, evaluation criteria, and specifications for: (1) site accessibility (external path of travel,…

  12. Specificity of Structural Assessment of Knowledge

    ERIC Educational Resources Information Center

    Trumpower, David L.; Sharara, Harold; Goldsmith, Timothy E.

    2010-01-01

    This study examines the specificity of information provided by structural assessment of knowledge (SAK). SAK is a technique which uses the Pathfinder scaling algorithm to transform ratings of concept relatedness into network representations (PFnets) of individuals' knowledge. Inferences about individuals' overall domain knowledge based on the…

  13. 18 CFR 1301.24 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Specific exemptions. 1301.24 Section 1301.24 Conservation of Power and Water Resources TENNESSEE VALLEY AUTHORITY PROCEDURES... Files-TVA,” and “Nuclear Quality Assurance Personnel Records-TVA” are exempted from subsections (d);...

  14. Non-Specific Immunotherapies and Adjuvants

    MedlinePlus

    ... and spinal cord. Other drugs that boost the immune system Some other drugs boost the immune system in a non-specific way, similar to cytokines. ... and CTLA-4, which normally help keep the immune system in check. While these checkpoint proteins are important ...

  15. 7 CFR 51.2952 - Size specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... diameter; except that for walnuts of the Eureka variety and type, such limiting dimension as to diameter shall be 76/64 inches; (d) Medium size. Medium size means walnuts of which at least 88 percent, by count... maximum diameter. Variety or Type Specifications...

  16. 7 CFR 51.2952 - Size specifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... round opening 77/64 inches in diameter; except that for walnuts of the Eureka variety and type, such limiting dimension as to diameter shall be 76/64 inches; (d) Medium size. Medium size means walnuts of... round hole of any specified maximum diameter. Variety or Type Specifications...

  17. 16 CFR 1209.35 - Product specification.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION Certification § 1209.35 Product specification. (a... insulation which is subject to the standard, it shall ensure that the insulation is described in a written... following information: (1) A description of the equipment used to manufacture the insulation, including...

  18. 16 CFR 1209.35 - Product specification.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION Certification § 1209.35 Product specification. (a... insulation which is subject to the standard, it shall ensure that the insulation is described in a written... following information: (1) A description of the equipment used to manufacture the insulation, including...

  19. 16 CFR 1209.35 - Product specification.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION Certification § 1209.35 Product specification. (a... insulation which is subject to the standard, it shall ensure that the insulation is described in a written... following information: (1) A description of the equipment used to manufacture the insulation, including...

  20. Trait mindfulness and autobiographical memory specificity.

    PubMed

    Crawley, Rosalind

    2015-02-01

    Training in mindfulness skills has been shown to increase autobiographical memory specificity. The aim of this study was to examine whether there is also an association between individual differences in trait mindfulness and memory specificity using a non-clinical student sample (N = 70). Also examined were the relationships between other memory characteristics and trait mindfulness, self-reported depression and rumination. Participants wrote about 12 autobiographical memories, which were recalled in response to emotion word cues in a minimal instruction version of the Autobiographical Memory Test, rated each memory for seven characteristics, and completed the Freiburg Mindfulness Inventory, the Depression, Anxiety, and Stress Scale, and the Ruminative Responses Scale. Higher rumination scores were associated with more reliving and more intense emotion during recall. Depression scores were not associated with any memory variables. Higher trait mindfulness was associated with lower memory specificity and with more intense and more positive emotion during recall. Thus, trait mindfulness is associated with memory specificity, but the association is opposite to that found in mindfulness training studies. It is suggested that this difference may be due to an influence of trait mindfulness on memory encoding as well as retrieval processes and an influence on the mode of self-awareness that leads to a greater focus on momentary rather than narrative self-reference. PMID:25120213

  1. 10 CFR 72.7 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Specific exemptions. 72.7 Section 72.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE General Provisions §...

  2. 10 CFR 72.7 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Specific exemptions. 72.7 Section 72.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE General Provisions §...

  3. 10 CFR 72.7 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Specific exemptions. 72.7 Section 72.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE General Provisions §...

  4. 10 CFR 72.7 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Specific exemptions. 72.7 Section 72.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE General Provisions §...

  5. The specificity of neuroprotection by antioxidants

    PubMed Central

    2009-01-01

    Background Reactive oxygen species (ROS) play an important role in aging and age-related diseases such as Parkinson's disease and Alzheimer's disease. Much of the ROS production under conditions of toxic stress is from mitochondria, and multiple antioxidants prevent ROS accumulation. The aim of this study is to examine the specificity of the interaction between the antioxidants and ROS production in stressed cells. Methods Using fluorescent dyes for ROS detection and mitochondrial inhibitors of known specificities, we studied ROS production under three conditions where ROS are produced by mitochondria: oxidative glutamate toxicity, state IV respiration induced by oligomycin, and tumor necrosis factor-induced cell death. Results We demonstrated that there are at least four mitochondrial ROS-generating sites in cells, including the flavin mononucleotide (FMN) group of complex I and the three ubiquinone-binding sites in complexes I, II and III. ROS production from these sites is modulated in an insult-specific manner and the sites are differentially accessible to common antioxidants. Conclusion The inhibition of ROS accumulation by different antioxidants is specific to the site of ROS generation as well as the antioxidant. This information should be useful for devising new interventions to delay aging or treat ROS-related diseases. PMID:19891782

  6. 31 CFR 586.315 - Specific license.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Specific license. 586.315 Section 586.315 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY FEDERAL REPUBLIC OF YUGOSLAVIA (SERBIA &...

  7. Pecking order among tumor-specific antigens.

    PubMed

    Urban, J L; Van Waes, C; Schreiber, H

    1984-02-01

    The ultraviolet light-induced fibrosarcoma 1591 is regularly rejected upon transplantation into young syngeneic mice; in rare instances, however, this tumor grows progressively and the tumors that develop are then heritably stable variant progressor tumors (1591-PRO tumors). In this study, we have induced transplantation resistance to 1591-PRO tumors and determined which antigens were recognized by mice that rejected these progressor tumors. We found that cytolytic T cells of such mice recognized a 1591-specific antigen that was present not only on all the independently derived 1591-PRO tumors but also on the parental regressor tumor (1591-RE). However, the cytolytic immune response of mice that rejected 1591-RE lysed 1591-RE tumor cells but not 1591-PRO tumor cells. Thus, the 1591-RE tumor seemed to express two antigens that were specific for tumors of the 1591 lineage, one that was lost and a second that was retained by 1591-PRO tumor cells. Mice challenged with 1591-R# tumor cells mounted a response to only one of the tumor-specific antigens which was therefore "immunodominant" over the other "immunorecessive" antigen. This immunorecessive antigen became the target of the immune response once the immunodominant antigen was lost. This "pecking order" interfered with the simultaneous recognition of two tumor-specific antigens and this mechanism may favor immune escape.

  8. Specificity, Transfer, and the Development of Expertise

    ERIC Educational Resources Information Center

    Brookes, David T.; Ross, Brian H.; Mestre, Jose P.

    2011-01-01

    In this paper we present the results of two experiments designed to understand how physics students' learning of the concept of refraction is influenced by the cognitive phenomenon of "specificity." In both experiments participants learned why light bends as it travels from one optical medium to another with an analogy made to a car driving from…

  9. 31 CFR 597.315 - Specific license.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Specific license. 597.315 Section 597.315 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY FOREIGN TERRORIST ORGANIZATIONS SANCTIONS...

  10. Specificity of aequorin luminescence to calcium

    NASA Technical Reports Server (NTRS)

    Shimomura, O.; Johnson, F. H.

    1975-01-01

    The presence of Pb(++), Co(++), Cu(++), and Cd(++), each of which possesses a certain luminescence-triggering activity of aequorin, potentially interferes with the specificity of the aequorin luminescence response to Ca(++). Interference by the above cations can be eliminated, without influencing the sensitivity of the luminescence of aequorin to Ca(++), by adding 1 mM of sodium diethyldithiocarbamate.

  11. The conformational specificity of viral epitopes.

    PubMed

    Van Regenmortel, M H

    1992-12-15

    Four types of antigenic sites found in viruses are discussed: cryptotopes, neotopes, metatopes and neutralization epitopes. The role played by conformation on the specificity of viral epitopes is illustrated in the case of tobacco mosaic virus and influenza virus. It appears that mechanisms reminiscent of induced fit contribute to the recognition of viral epitopes by antibodies.

  12. Microscale purification of antigen-specific antibodies

    PubMed Central

    Brown, Eric P.; Normandin, Erica; Osei-Owusu, Nana Yaw; Mahan, Alison E.; Chan, Ying N.; Lai, Jennifer I.; Vaccari, Monica; Rao, Mangala; Franchini, Genoveffa; Alter, Galit; Ackerman, Margaret E.

    2015-01-01

    Glycosylation of the Fc domain is an important driver of antibody effector function. While assessment of antibody glycoform compositions observed across total plasma IgG has identified differences associated with a variety of clinical conditions, in many cases it is the glycosylation state of only antibodies against a specific antigen or set of antigens that may be of interest, for example, in defining the potential effector function of antibodies produced during disease or after vaccination. Historically, glycoprofiling such antigen-specific antibodies in clinical samples has been challenging due to their low prevalence, the high sample requirement for most methods of glycan determination, and the lack of high-throughput purification methods. New methods of glycoprofiling with lower sample requirements and higher throughput have motivated the development of microscale and automatable methods for purification of antigen-specific antibodies from polyclonal sources such as clinical serum samples. In this work, we present a robot-compatible 96-well plate-based method for purification of antigen-specific antibodies, suitable for such population level glycosylation screening. We demonstrate the utility of this method across multiple antibody sources, using both purified plasma IgG and plasma, and across multiple different antigen types, with enrichment factors greater than 1000-fold observed. Using an on-column IdeS protease treatment, we further describe staged release of Fc and Fab domains, allowing for glycoprofiling of each domain. PMID:26078040

  13. 37 CFR 102.34 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .../DEPT-14; (D) Attorneys and Agents Registered to Practice Before the Office—COMMERCE/PAT-TM-1; (E... OF COMMERCE ADMINISTRATION DISCLOSURE OF GOVERNMENT INFORMATION Privacy Act § 102.34 Specific... are within this exemption are: COMMERCE/PAT-TM-6, COMMERCE/PAT-TM-7, COMMERCE/PAT-TM-8,...

  14. 37 CFR 102.34 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .../DEPT-14; (D) Attorneys and Agents Registered to Practice Before the Office—COMMERCE/PAT-TM-1; (E... OF COMMERCE ADMINISTRATION DISCLOSURE OF GOVERNMENT INFORMATION Privacy Act § 102.34 Specific... are within this exemption are: COMMERCE/PAT-TM-6, COMMERCE/PAT-TM-7, COMMERCE/PAT-TM-8,...

  15. 31 CFR 597.315 - Specific license.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Specific license. 597.315 Section 597.315 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY FOREIGN TERRORIST ORGANIZATIONS SANCTIONS...

  16. 31 CFR 597.315 - Specific license.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Specific license. 597.315 Section 597.315 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY FOREIGN TERRORIST ORGANIZATIONS SANCTIONS...

  17. 31 CFR 597.315 - Specific license.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Specific license. 597.315 Section 597.315 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY FOREIGN TERRORIST ORGANIZATIONS SANCTIONS...

  18. 31 CFR 597.315 - Specific license.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Specific license. 597.315 Section 597.315 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY FOREIGN TERRORIST ORGANIZATIONS SANCTIONS...

  19. Species-specific proteins in fossils

    NASA Astrophysics Data System (ADS)

    Lowenstein, Jerold M.

    1980-07-01

    With a solid-phase radioimmunoassay it has been possible to detect species-specific collagen and albumin in fossils as old as 1.9 million years. This technique may provide new data on the genetic relations of fossil species to each other and to living forms.

  20. 46 CFR 172.047 - Specific applicability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Specific applicability. 172.047 Section 172.047 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO BULK CARGOES Special Rules Pertaining to a Barge That Carries a Cargo Regulated Under Subchapter D of This Chapter § 172.047...

  1. Prostate-specific antigen (PSA) blood test

    MedlinePlus

    Prostate-specific antigen; Prostate cancer screening test; PSA ... special steps are needed to prepare for this test. ... Reasons for a PSA test: This test may be done to screen for prostate cancer. It is also used to follow people after prostate cancer ...

  2. 10 CFR 50.12 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., the availability of alternative sources, if any, to meet those needs on a timely basis and delay costs... 10 Energy 1 2012-01-01 2012-01-01 false Specific exemptions. 50.12 Section 50.12 Energy NUCLEAR... activities would foreclose subsequent adoption of alternatives; and (4) The effect of delay in...

  3. Core Curriculum. A Workplace Specific Curriculum.

    ERIC Educational Resources Information Center

    Nickles, Ann; And Others

    This core curriculum is designed for use in helping employees participating in a workplace-specific basic skills program develop basic team-building skills while simultaneously developing basic reading, writing, and mathematics skills. Although many of the instructional materials and sample forms included are applicable to employees in most…

  4. English for Specific Purposes. Information Guide 2.

    ERIC Educational Resources Information Center

    British Council, London (England). English-Teaching Information Centre.

    This bibliography of materials for teachers of English for specific purposes lists textbooks, technical readers, articles, resource books, reports, dictionaries, reference books, bibliographies, word frequency lists, catalogues of teaching aids, games and activities, current research in Britain, documents available in the archives of the English…

  5. 30 CFR 22.7 - Specific requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... APPROVAL OF MINING PRODUCTS PORTABLE METHANE DETECTORS § 22.7 Specific requirements. (a) Design. In the... shall be of such design that it will not produce sparks that will ignite an explosive mixture of methane and air. (5) Detectors of the flame type. Methane detectors of the flame type shall be subject to...

  6. 30 CFR 22.7 - Specific requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... APPROVAL OF MINING PRODUCTS PORTABLE METHANE DETECTORS § 22.7 Specific requirements. (a) Design. In the... shall be of such design that it will not produce sparks that will ignite an explosive mixture of methane and air. (5) Detectors of the flame type. Methane detectors of the flame type shall be subject to...

  7. 16 CFR 1702.11 - Product specifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Product specifications. 1702.11 Section 1702.11 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION...

  8. 16 CFR 1702.11 - Product specifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Product specifications. 1702.11 Section 1702.11 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION...

  9. 16 CFR 1702.12 - Packaging specifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Packaging specifications. 1702.12 Section 1702.12 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION...

  10. 16 CFR 1702.11 - Product specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Product specifications. 1702.11 Section 1702.11 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION...

  11. 16 CFR 1702.12 - Packaging specifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Packaging specifications. 1702.12 Section 1702.12 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION...

  12. 16 CFR 1702.12 - Packaging specifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Packaging specifications. 1702.12 Section 1702.12 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION...

  13. 16 CFR 1702.12 - Packaging specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Packaging specifications. 1702.12 Section 1702.12 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION...

  14. 16 CFR 1702.11 - Product specifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Product specifications. 1702.11 Section 1702.11 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION...

  15. 16 CFR 1702.12 - Packaging specifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Packaging specifications. 1702.12 Section 1702.12 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION...

  16. 16 CFR 1702.11 - Product specifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Product specifications. 1702.11 Section 1702.11 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION...

  17. Microscale purification of antigen-specific antibodies.

    PubMed

    Brown, Eric P; Normandin, Erica; Osei-Owusu, Nana Yaw; Mahan, Alison E; Chan, Ying N; Lai, Jennifer I; Vaccari, Monica; Rao, Mangala; Franchini, Genoveffa; Alter, Galit; Ackerman, Margaret E

    2015-10-01

    Glycosylation of the Fc domain is an important driver of antibody effector function. While assessment of antibody glycoform compositions observed across total plasma IgG has identified differences associated with a variety of clinical conditions, in many cases it is the glycosylation state of only antibodies against a specific antigen or set of antigens that may be of interest, for example, in defining the potential effector function of antibodies produced during disease or after vaccination. Historically, glycoprofiling such antigen-specific antibodies in clinical samples has been challenging due to their low prevalence, the high sample requirement for most methods of glycan determination, and the lack of high-throughput purification methods. New methods of glycoprofiling with lower sample requirements and higher throughput have motivated the development of microscale and automatable methods for purification of antigen-specific antibodies from polyclonal sources such as clinical serum samples. In this work, we present a robot-compatible 96-well plate-based method for purification of antigen-specific antibodies, suitable for such population level glycosylation screening. We demonstrate the utility of this method across multiple antibody sources, using both purified plasma IgG and plasma, and across multiple different antigen types, with enrichment factors greater than 1000-fold observed. Using an on-column IdeS protease treatment, we further describe staged release of Fc and Fab domains, allowing for glycoprofiling of each domain.

  18. Pairing and specific heat in hot nuclei

    NASA Astrophysics Data System (ADS)

    Gambacurta, Danilo; Lacroix, Denis; Sandulescu, N.

    2013-09-01

    The thermodynamics of pairing phase-transition in nuclei is studied in the canonical ensemble and treating the pairing correlations in a finite-temperature variation after projection BCS approach (FT-VAP). Due to the restoration of particle number conservation, the pairing gap and the specific heat calculated in the FT-VAP approach vary smoothly with the temperature, indicating a gradual transition from the superfluid to the normal phase, as expected in finite systems. We have checked that the predictions of the FT-VAP approach are very accurate when compared to the results obtained by an exact diagonalization of the pairing Hamiltonian. The influence of pairing correlations on specific heat is analyzed for the isotopes 161,162Dy and 171,172Yb. It is shown that the FT-VAP approach, applied with a level density provided by mean field calculations and supplemented, at high energies, by the level density of the back-shifted Fermi gas model, can approximate reasonably well the main properties of specific heat extracted from experimental data. However, the detailed shape of the calculated specific heat is rather sensitive to the assumption made for the mean field.

  19. 28 CFR 0.131 - Specific functions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., Tobacco, Firearms, and Explosives § 0.131 Specific functions. The Director of the Bureau of Alcohol, Tobacco, Firearms, and Explosives shall: (a) Operate laboratories in support of Bureau activities; provide... maintain an explosives license and permit database; (c) Operate the National Firearms Licensing Center...

  20. 28 CFR 0.131 - Specific functions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., Tobacco, Firearms, and Explosives § 0.131 Specific functions. The Director of the Bureau of Alcohol, Tobacco, Firearms, and Explosives shall: (a) Operate laboratories in support of Bureau activities; provide... maintain an explosives license and permit database; (c) Operate the National Firearms Licensing Center...

  1. 28 CFR 0.131 - Specific functions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., Tobacco, Firearms, and Explosives § 0.131 Specific functions. The Director of the Bureau of Alcohol, Tobacco, Firearms, and Explosives shall: (a) Operate laboratories in support of Bureau activities; provide... maintain an explosives license and permit database; (c) Operate the National Firearms Licensing Center...

  2. 28 CFR 0.131 - Specific functions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., Tobacco, Firearms, and Explosives § 0.131 Specific functions. The Director of the Bureau of Alcohol, Tobacco, Firearms, and Explosives shall: (a) Operate laboratories in support of Bureau activities; provide... maintain an explosives license and permit database; (c) Operate the National Firearms Licensing Center...

  3. Dancing in Place: Site-Specific Work

    ERIC Educational Resources Information Center

    Metal-Corbin, Josie

    2012-01-01

    In her lecture the 2012 NDA Scholar/Artist, Josie Metal-Corbin, chronicles four decades of working with artists, educators, librarians, and scientists. The kinetic language of dance and the visual impact of specific environments provide provocative opportunities for collaboration, wherein the site becomes the framework or map for the dance design.…

  4. VOSpace specification Version 1.15

    NASA Astrophysics Data System (ADS)

    Graham, Matthew; Morris, Dave; Rixon, Guy; Graham, Matthew

    2009-10-01

    VOSpace is the IVOA interface to distributed storage. This version extends the existing VOSpace 1.0 (SOAP-based) specification to support containers, links between individual VOSpace instances, third party APIs, and a find mechanism. Note, however, that VOSpace-1.0 compatible clients will not work with this new version of the interface.

  5. Improved specificity of hippocampal memory trace labeling.

    PubMed

    Cazzulino, Alejandro S; Martinez, Randy; Tomm, Nicole K; Denny, Christine A

    2016-06-01

    Recent studies have focused on the identification and manipulation of memory traces in rodent models. The two main mouse models utilized are either a CreER(T2) /loxP tamoxifen (TAM)- or a tetracycline transactivator/tetracycline-response element doxycycline-inducible system. These systems, however, could be improved to label a more specific population of activated neurons corresponding to behavior. Here, we sought to identify an improved selective estrogen receptor (ER) modulator (SERM) in which we could label an individual memory trace in ArcCreER(T2) mice. We found that 4-hydroxytamoxifen (4-OHT) is a selective SERM in the ArcCreER(T2) × Rosa26-CAG-stop(flox) -channelrhodospin (ChR2)-enhanced yellow fluorescent protein (eYFP) mice. The half-life of 4-OHT is shorter than TAM, allowing for more specificity of memory trace labeling. Furthermore, 4-OHT allowed for context-specific labeling in the dentate gyrus and CA3. In summary, we believe that 4-OHT improves the specificity of memory trace labeling and will allow for refined memory trace studies in the future. © 2015 Wiley Periodicals, Inc. PMID:26662713

  6. Analyzing Languages for Specific Purposes Discourse

    ERIC Educational Resources Information Center

    Bowles, Hugo

    2012-01-01

    In the last 20 years, technological advancement and increased multidisciplinarity has expanded the range of data regarded as within the scope of languages for specific purposes (LSP) research and the means by which they can be analyzed. As a result, the analytical work of LSP researchers has developed from a narrow focus on specialist terminology…

  7. Estimating Genotype- and Environment-Specific Heritabilities

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The advantages of computing genotype- and environment-specific heritabilities are discussed. A statistical approach is used in which logvariances of both genotype by environment interaction and error are modeled as random variables. Resulting estimators of variances are weighted averages of a pool...

  8. Teaching Case: Enterprise Architecture Specification Case Study

    ERIC Educational Resources Information Center

    Steenkamp, Annette Lerine; Alawdah, Amal; Almasri, Osama; Gai, Keke; Khattab, Nidal; Swaby, Carval; Abaas, Ramy

    2013-01-01

    A graduate course in enterprise architecture had a team project component in which a real-world business case, provided by an industry sponsor, formed the basis of the project charter and the architecture statement of work. The paper aims to share the team project experience on developing the architecture specifications based on the business case…

  9. 50 CFR 648.41 - Framework specifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Atlantic Salmon § 648.41 Framework specifications. (a) Within season management action. The New England... Atlantic salmon management measures to allow for Atlantic salmon aquaculture projects in the EEZ, provided such an action is consistent with the goals and objectives of the Atlantic Salmon FMP. (b)...

  10. 50 CFR 648.41 - Framework specifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Atlantic Salmon § 648.41 Framework specifications. (a) Within season management action. The New England... Atlantic salmon management measures to allow for Atlantic salmon aquaculture projects in the EEZ, provided such an action is consistent with the goals and objectives of the Atlantic Salmon FMP. (b)...

  11. 50 CFR 648.41 - Framework specifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Atlantic Salmon § 648.41 Framework specifications. (a) Within season management action. The New England... Atlantic salmon management measures to allow for Atlantic salmon aquaculture projects in the EEZ, provided such an action is consistent with the goals and objectives of the Atlantic Salmon FMP. (b)...

  12. 50 CFR 648.41 - Framework specifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Atlantic Salmon § 648.41 Framework specifications. (a) Within season management action. The New England... Atlantic salmon management measures to allow for Atlantic salmon aquaculture projects in the EEZ, provided such an action is consistent with the goals and objectives of the Atlantic Salmon FMP. (b)...

  13. 31 CFR 539.311 - Specific license.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Specific license. 539.311 Section 539.311 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY WEAPONS OF MASS DESTRUCTION TRADE CONTROL...

  14. 78 FR 44894 - Specifications for Packagings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration 49 CFR Part 178 Specifications for Packagings CFR Correction 0 In Title 49 of the Code of Federal Regulations, Parts 178 to 199, revised as of October 1,...

  15. Ribosomopathies: Global process, tissue specific defects.

    PubMed

    Yelick, Pamela C; Trainor, Paul A

    2015-01-01

    Disruptions in ribosomal biogenesis would be expected to have global and in fact lethal effects on a developing organism. However, mutations in ribosomal protein genes have been shown in to exhibit tissue specific defects. This seemingly contradictory finding - that globally expressed genes thought to play fundamental housekeeping functions can in fact exhibit tissue and cell type specific functions - provides new insight into roles for ribosomes, the protein translational machinery of the cell, in regulating normal development and disease. Furthermore it illustrates the surprisingly dynamic nature of processes regulating cell type specific protein translation. In this review, we discuss our current knowledge of a variety of ribosomal protein mutations associated with human disease, and models to better understand the molecular mechanisms associated with each. We use specific examples to emphasize both the similarities and differences between the effects of various human ribosomal protein mutations. Finally, we discuss areas of future study that are needed to further our understanding of the role of ribosome biogenesis in normal development, and possible approaches that can be used to treat debilitating ribosomopathy diseases. PMID:26442198

  16. 24 CFR 16.15 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Specific exemptions. 16.15 Section 16.15 Housing and Urban Development Office of the Secretary, Department of Housing and Urban... Housing and Urban Development determines it to be necessary and proper, with respect to any system...

  17. 24 CFR 2003.9 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 5 2011-04-01 2011-04-01 false Specific exemptions. 2003.9 Section 2003.9 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF INSPECTOR GENERAL, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT IMPLEMENTATION OF THE...

  18. 24 CFR 2003.9 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Specific exemptions. 2003.9 Section 2003.9 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF INSPECTOR GENERAL, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT IMPLEMENTATION OF THE...

  19. 50 CFR 216.105 - Specific regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Specific regulations. 216.105 Section 216... ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS General Regulations Governing Small Takes of Marine Mammals Incidental to Specified...

  20. 50 CFR 216.105 - Specific regulations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 10 2014-10-01 2014-10-01 false Specific regulations. 216.105 Section 216... ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS General Regulations Governing Small Takes of Marine Mammals Incidental to Specified...