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Sample records for aashto lrfd specifications

  1. Re-Evaluation of the AASHTO-Flexible Pavement Design Equation with Neural Network Modeling

    PubMed Central

    Tiğdemir, Mesut

    2014-01-01

    Here we establish that equivalent single-axle loads values can be estimated using artificial neural networks without the complex design equality of American Association of State Highway and Transportation Officials (AASHTO). More importantly, we find that the neural network model gives the coefficients to be able to obtain the actual load values using the AASHTO design values. Thus, those design traffic values that might result in deterioration can be better calculated using the neural networks model than with the AASHTO design equation. The artificial neural network method is used for this purpose. The existing AASHTO flexible pavement design equation does not currently predict the pavement performance of the strategic highway research program (Long Term Pavement Performance studies) test sections very accurately, and typically over-estimates the number of equivalent single axle loads needed to cause a measured loss of the present serviceability index. Here we aimed to demonstrate that the proposed neural network model can more accurately represent the loads values data, compared against the performance of the AASHTO formula. It is concluded that the neural network may be an appropriate tool for the development of databased-nonparametric models of pavement performance. PMID:25397962

  2. Threaded connection limit state equations for use in LRFD tubular design

    SciTech Connect

    Schwind, B.E.; Chappell, J.F.; Katsounas, A.T.

    1995-12-31

    The purpose of the study was to identify and evaluate the variables that determine the leak resistance limit state functions of API 8-round and buttress connections. This work will be incorporated into Load and Resistance Factor Design (LRFD) equations. Connectors are an integral part any well design program. Therefore, it is vital that they be included in the LRFD design approach. Makeup, tension, internal pressure and dimensional data were among the variables in the evaluation, which was based on finite element analysis, testing and structural mechanics. The leak resistance limit state for round thread connections is defined by contact pressure, stab flank engaged length and coupling yield, while for buttress is defined by contact pressure, stab flank clearance and coupling yield. Leak pressure, as defined by API Bul. 5C3, is a function of makeup and dimensional data independent of thread type, tension, and pipe inside diameter and valid only in the elastic regime. Tension is detrimental in the leak resistance of 8-round connections, but does not compromise buttress leak resistance. Regression analysis was performed on structural mechanics results to produce the highest correlation to finite element results to account for end effects on round thread connections. It was determined by testing that stab flank contact over a minimum length of engagement is not sufficient to prevent 8-round leak, despite sufficient contact pressure level. Teflon impregnated thread compound should be the choice for API buttress. The indications are that optimized makeup should be considered in the leak resistance capacity of API connections.

  3. Refinement of Strut-and-Tie Model for Reinforced Concrete Deep Beams.

    PubMed

    Panjehpour, Mohammad; Chai, Hwa Kian; Voo, Yen Lei

    2015-01-01

    Deep beams are commonly used in tall buildings, offshore structures, and foundations. According to many codes and standards, strut-and-tie model (STM) is recommended as a rational approach for deep beam analyses. This research focuses on the STM recommended by ACI 318-11 and AASHTO LRFD and uses experimental results to modify the strut effectiveness factor in STM for reinforced concrete (RC) deep beams. This study aims to refine STM through the strut effectiveness factor and increase result accuracy. Six RC deep beams with different shear span to effective-depth ratios (a/d) of 0.75, 1.00, 1.25, 1.50, 1.75, and 2.00 were experimentally tested under a four-point bending set-up. The ultimate shear strength of deep beams obtained from non-linear finite element modeling and STM recommended by ACI 318-11 as well as AASHTO LRFD (2012) were compared with the experimental results. An empirical equation was proposed to modify the principal tensile strain value in the bottle-shaped strut of deep beams. The equation of the strut effectiveness factor from AASHTTO LRFD was then modified through the aforementioned empirical equation. An investigation on the failure mode and crack propagation in RC deep beams subjected to load was also conducted. PMID:26110268

  4. Refinement of Strut-and-Tie Model for Reinforced Concrete Deep Beams

    PubMed Central

    Panjehpour, Mohammad; Chai, Hwa Kian; Voo, Yen Lei

    2015-01-01

    Deep beams are commonly used in tall buildings, offshore structures, and foundations. According to many codes and standards, strut-and-tie model (STM) is recommended as a rational approach for deep beam analyses. This research focuses on the STM recommended by ACI 318-11 and AASHTO LRFD and uses experimental results to modify the strut effectiveness factor in STM for reinforced concrete (RC) deep beams. This study aims to refine STM through the strut effectiveness factor and increase result accuracy. Six RC deep beams with different shear span to effective-depth ratios (a/d) of 0.75, 1.00, 1.25, 1.50, 1.75, and 2.00 were experimentally tested under a four-point bending set-up. The ultimate shear strength of deep beams obtained from non-linear finite element modeling and STM recommended by ACI 318-11 as well as AASHTO LRFD (2012) were compared with the experimental results. An empirical equation was proposed to modify the principal tensile strain value in the bottle-shaped strut of deep beams. The equation of the strut effectiveness factor from AASHTTO LRFD was then modified through the aforementioned empirical equation. An investigation on the failure mode and crack propagation in RC deep beams subjected to load was also conducted. PMID:26110268

  5. 23 CFR 625.4 - Standards, policies, and standard specifications.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Traffic Signals, AASHTO 1994. (11) Navigational Clearances for Bridges, refer to 23 CFR part 650, subpart...) Procedures for Abatement of Highway Traffic Noise and Construction Noise, refer to 23 CFR part 772. (7... of the Federal Register in accordance with 5 U.S.C. 552(a) and 1 CFR part 51 and are on file at...

  6. 23 CFR 625.4 - Standards, policies, and standard specifications.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Traffic Signals, AASHTO 1994. (11) Navigational Clearances for Bridges, refer to 23 CFR part 650, subpart...) Procedures for Abatement of Highway Traffic Noise and Construction Noise, refer to 23 CFR part 772. (7... of the Federal Register in accordance with 5 U.S.C. 552(a) and 1 CFR part 51 and are on file at...

  7. 23 CFR 625.4 - Standards, policies, and standard specifications.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Traffic Signals, AASHTO 1994. (11) Navigational Clearances for Bridges, refer to 23 CFR part 650, subpart...) Procedures for Abatement of Highway Traffic Noise and Construction Noise, refer to 23 CFR part 772. (7... of the Federal Register in accordance with 5 U.S.C. 552(a) and 1 CFR part 51 and are on file at...

  8. Safety identifying of integral abutment bridges under seismic and thermal loads.

    PubMed

    Easazadeh Far, Narges; Barghian, Majid

    2014-01-01

    Integral abutment bridges (IABs) have many advantages over conventional bridges in terms of strength and maintenance cost. Due to the integrity of these structures uniform thermal and seismic loads are known important ones on the structure performance. Although all bridge design codes consider temperature and earthquake loads separately in their load combinations for conventional bridges, the thermal load is an "always on" load and, during the occurrence of an earthquake, these two important loads act on bridge simultaneously. Evaluating the safety level of IABs under combination of these loads becomes important. In this paper, the safety of IABs--designed by AASHTO LRFD bridge design code--under combination of thermal and seismic loads is studied. To fulfill this aim, first the target reliability indexes under seismic load have been calculated. Then, these analyses for the same bridge under combination of thermal and seismic loads have been repeated and the obtained reliability indexes are compared with target indexes. It is shown that, for an IAB designed by AASHTO LRFD, the indexes have been reduced under combined effects. So, the target level of safety during its design life is not provided and the code's load combination should be changed. PMID:25405232

  9. Safety Identifying of Integral Abutment Bridges under Seismic and Thermal Loads

    PubMed Central

    Easazadeh Far, Narges; Barghian, Majid

    2014-01-01

    Integral abutment bridges (IABs) have many advantages over conventional bridges in terms of strength and maintenance cost. Due to the integrity of these structures uniform thermal and seismic loads are known important ones on the structure performance. Although all bridge design codes consider temperature and earthquake loads separately in their load combinations for conventional bridges, the thermal load is an “always on” load and, during the occurrence of an earthquake, these two important loads act on bridge simultaneously. Evaluating the safety level of IABs under combination of these loads becomes important. In this paper, the safety of IABs—designed by AASHTO LRFD bridge design code—under combination of thermal and seismic loads is studied. To fulfill this aim, first the target reliability indexes under seismic load have been calculated. Then, these analyses for the same bridge under combination of thermal and seismic loads have been repeated and the obtained reliability indexes are compared with target indexes. It is shown that, for an IAB designed by AASHTO LRFD, the indexes have been reduced under combined effects. So, the target level of safety during its design life is not provided and the code's load combination should be changed. PMID:25405232

  10. Specification Reformulation During Specification Validation

    NASA Technical Reports Server (NTRS)

    Benner, Kevin M.

    1992-01-01

    The goal of the ARIES Simulation Component (ASC) is to uncover behavioral errors by 'running' a specification at the earliest possible points during the specification development process. The problems to be overcome are the obvious ones the specification may be large, incomplete, underconstrained, and/or uncompilable. This paper describes how specification reformulation is used to mitigate these problems. ASC begins by decomposing validation into specific validation questions. Next, the specification is reformulated to abstract out all those features unrelated to the identified validation question thus creating a new specialized specification. ASC relies on a precise statement of the validation question and a careful application of transformations so as to preserve the essential specification semantics in the resulting specialized specification. This technique is a win if the resulting specialized specification is small enough so the user my easily handle any remaining obstacles to execution. This paper will: (1) describe what a validation question is; (2) outline analysis techniques for identifying what concepts are and are not relevant to a validation question; and (3) identify and apply transformations which remove these less relevant concepts while preserving those which are relevant.

  11. Military specifications

    NASA Technical Reports Server (NTRS)

    Reynolds, Philip

    1987-01-01

    The current situation relative to the military specification is that there is not one specific model of turbulence which people are using. Particular disagreement exists on how turbulence levels will vary with qualitative analysis. It does not tie one down to specifics. When it comes to flying quality specifications, many feel that one should stay with the definitions of the Cooper-Harper rating scale but allow the levels to shift depending on the level of turbulence. There is a ride quality specification in the MIL-SPEC having to do with flight control systems design that is related to a turbulence model. This spec (MIL-F8785C) and others are discussed.

  12. Building Specifications

    NASA Technical Reports Server (NTRS)

    1978-01-01

    The building in the top photo is the new home of the National Permanent Savings Bank in Washington, D.C., designed by Hartman-Cox Architects. Its construction was based on a money-saving method of preparing building specifications which derived from NASA technology developed to obtain quality construction while holding down cost of launch facilities, test centers and other structures. Written technical specifications spell out materials and components to be used on construction projects and identify the quality tests each item must pass. Specifications can have major impact on construction costs. Poorly formulated specifications can lead to unacceptable construction which must be replaced, unnecessarily high materials costs, safety hazards, disputes and often additional costs due to delays and litigation. NASA's Langley Research Center developed a novel approach to providing accurate, uniform, cost-effective specifications which can be readily updated to incorporate new building technologies. Called SPECSINTACT, it is a computerized - system accessible to all NASA centers involved in construction programs. The system contains a comprehensive catalog of master specifications applicable to many types of construction. It enables designers of any structure to call out relevant sections from computer storage and modify them to fit the needs of the project at hand. Architects and engineers can save time by concentrating their efforts on needed modifications rather than developing all specifications from scratch. Successful use of SPECSINTACT has led to a number of spinoff systems. One of the first was MASTERSPEC, developed from NASA's experience by Production Systems for Architects and Engineers, Inc., an organization established by the American Institute of Architects. MASTERSPEC, used in construction of the bank building pictured, follows the same basic format as SPECSINTACT and can be used in either automated or manual modes. The striking appearance of the bank

  13. Specifying Specification.

    PubMed

    Paulo, Norbert

    2016-03-01

    This paper tackles the accusation that applied ethics is no serious academic enterprise because it lacks theoretical bracing. It does so in two steps. In the first step I introduce and discuss a highly acclaimed method to guarantee stability in ethical theories: Henry Richardson's specification. The discussion shows how seriously ethicists take the stability of the connection between the foundational parts of their theories and their further development as well as their "application" to particular problems or cases. A detailed scrutiny of specification leads to the second step, where I use insights from legal theory to inform the debate around stability from that point of view. This view reveals some of specification's limitations. I suggest that, once specification is sufficiently specified, it appears astonishingly similar to deduction as used in legal theory. Legal theory also provides valuable insight into the functional range of deduction and its relation to other forms of reasoning. This leads to a richer understanding of stability in normative theories and to a smart division of labor between deduction and other forms of reasoning. The comparison to legal theory thereby provides a framework for how different methods such as specification, deduction, balancing, and analogy relate to one another. PMID:27157109

  14. Specific Dyslexia.

    ERIC Educational Resources Information Center

    Naidoo, Sandhya

    The investigation reported in this volume attempts to clarify some issues relating to the existence, nature, and causes of specific dyslexia. Based on an extended study of 98 boys of at least average intelligence with severe reading and spelling problems, the report provides detailed data relating to their developmental and perinatal histories,…

  15. Specific Suspicion

    ERIC Educational Resources Information Center

    Taylor, Kelley R.

    2009-01-01

    This article discusses a recent case decided by the U.S. Supreme Court which highlights the importance of having specific suspicions of misbehavior before conducting a strip search. The case involves an eighth-grade female student who was being strip-searched by a middle school assistant principal, a school nurse, and an administrative assistant…

  16. Specific phobias.

    PubMed

    Hamm, Alfons O

    2009-09-01

    Exposure based treatments in which patients are systematically confronted with their feared objects of situations are highly effective in the treatment of specific phobias and produce stable improvement both in reported fear and behavioral avoidance. Exposure in reality is more effective in most cases than exposure in sensu. For situations that are difficult to realize, exposure in virtual environments has become increasingly valuable. Exposure in vivo is clearly superior to pharmacotherapy, although cognitive enhancers have been successfully used recently to increase the effect of exposure therapy. The induction of relaxation is not a necessary precondition for exposure therapy. Rather the current mechanisms of change focus on extinction learning as being the central mechanism both on a cognitive level namely that the feared object is no longer associated with severely threatening consequence but also on an affective level, meaning that feared cue is no longer capable to activate the fear circuit in the brain. Accordingly future diagnostic categorizations of phobic disorders in the DSM-V should rather focus on the pattern of the fear response that needs to be changed than on the eliciting cues or situations that are avoided. PMID:19716991

  17. Intent Specifications

    NASA Technical Reports Server (NTRS)

    Leveson, Nancy G.

    1995-01-01

    We have been investigating the implications of using abstractions based on intent rather than the aggregation and information-hiding abstractions commonly used in software en- gineering: Cognitive psychologists have shown that intent abstraction is consistent with human problem-solving processes. We believe that new types of specifications and designs based on this concept can assist in understanding and specifying requirements, capturing the most important design rationale information in an efficient and economical way, and supporting the process of identifying and analyzing required changes to minimize the introduction of errors. The goal of hierarchical abstraction is to allow both top-down and bottom-up reasoning about a complex system. In computer science, we have made much use of (1) part-whole abstractions where each level of a hierarchy represents an aggregation of the components at a lower level and of (2) information-hiding abstractions where each level contains the same conceptual information but hides some details about the concepts, that is, each level is a refinement of the information at a higher level.

  18. Improved Simplified Methods for Effective Seismic Analysis and Design of Isolated and Damped Bridges in Western and Eastern North America

    NASA Astrophysics Data System (ADS)

    Koval, Viacheslav

    The seismic design provisions of the CSA-S6 Canadian Highway Bridge Design Code and the AASHTO LRFD Seismic Bridge Design Specifications have been developed primarily based on historical earthquake events that have occurred along the west coast of North America. For the design of seismic isolation systems, these codes include simplified analysis and design methods. The appropriateness and range of application of these methods are investigated through extensive parametric nonlinear time history analyses in this thesis. It was found that there is a need to adjust existing design guidelines to better capture the expected nonlinear response of isolated bridges. For isolated bridges located in eastern North America, new damping coefficients are proposed. The applicability limits of the code-based simplified methods have been redefined to ensure that the modified method will lead to conservative results and that a wider range of seismically isolated bridges can be covered by this method. The possibility of further improving current simplified code methods was also examined. By transforming the quantity of allocated energy into a displacement contribution, an idealized analytical solution is proposed as a new simplified design method. This method realistically reflects the effects of ground-motion and system design parameters, including the effects of a drifted oscillation center. The proposed method is therefore more appropriate than current existing simplified methods and can be applicable to isolation systems exhibiting a wider range of properties. A multi-level-hazard performance matrix has been adopted by different seismic provisions worldwide and will be incorporated into the new edition of the Canadian CSA-S6-14 Bridge Design code. However, the combined effect and optimal use of isolation and supplemental damping devices in bridges have not been fully exploited yet to achieve enhanced performance under different levels of seismic hazard. A novel Dual-Level Seismic

  19. Mining Specifications: A Roadmap

    NASA Astrophysics Data System (ADS)

    Zeller, Andreas

    Recent advances in software validation and verification make it possible to widely automate whether a specification is satisfied. This progress is hampered, though, by the persistent difficulty of writing specifications. Are we facing a “specification crisis”? In this paper, I show how to alleviate the burden of writing specifications by reusing and extending specifications as mined from existing software and give an overview on the state of the art in specification mining, its origins, and its potential.

  20. Urine specific gravity test

    MedlinePlus

    Urine specific gravity is a laboratory test that shows the concentration of all chemical particles in the urine. ... changes to will tell the provider the specific gravity of your urine. The dipstick test gives only ...

  1. Urine specific gravity test

    MedlinePlus

    ... page: //medlineplus.gov/ency/article/003587.htm Urine specific gravity test To use the sharing features on this page, please enable JavaScript. Urine specific gravity is a laboratory test that shows the concentration ...

  2. Improved technical specifications

    SciTech Connect

    Hoffman, D.R.

    1994-12-31

    Improved technical specifications for nuclear power plants are outlined. The objectives of this work are to improve safety, provide a clearer understanding of safety significance, and ease NRC and industry administrative burdens. Line item improvements, bases, and implementation of the specifications are discussed.

  3. Prototype Facility Educational Specifications.

    ERIC Educational Resources Information Center

    Idaho State Div. of Professional-Technical Education, Boise.

    This document presents prototypical educational specifications to guide the building and renovation of Idaho vocational schools so they can help communities meet the advanced, professional-technical programs of the future. The specifications start with points to consider when determining school site suitability. The document then sets forth…

  4. Specific Genetic Disorders

    MedlinePlus

    ... of Genetic Terms Definitions for genetic terms Specific Genetic Disorders Many human diseases have a genetic component. ... Condition in an Adult The Undiagnosed Diseases Program Genetic Disorders Achondroplasia Alpha-1 Antitrypsin Deficiency Antiphospholipid Syndrome ...

  5. VOST charcoal specification study

    SciTech Connect

    Foster, A.L.; Bursey, J.T.

    1995-07-01

    The volatile organic sampling train, SW-846 Method 0030, (VOST) is currently one of the leading methodology`s available for the sampling and analysis of volatile organic hazardous compounds from stationary sources at very low levels. The method does not identify a specific equivalent sorbent, nor the performance specifications which would allow determination of an equivalent. Lot 104 petroleum-based charcoal is no longer commercially available. Laboratories are presently using a wide range of substitutes with varying performance from batch to batch of charcoal. To provide performance specifications and identify a replacement for SKC Lot 104 charcoal, a VOST charcoal specification study was initiated. Performance, cost, ease of handling, and plentiful supply make Anasorb 747 a good choice for replacement of SKX Lot 104.

  6. Phobia - simple/specific

    MedlinePlus

    ... person may feel extremely anxious or has a panic attack when exposed to the object of fear. Specific ... behavioral therapy, including learning to recognize and replace ... include: Getting regular exercise Getting enough sleep Reducing ...

  7. Harmonization of Biodiesel Specifications

    SciTech Connect

    Alleman, T. L.

    2008-02-01

    Worldwide biodiesel production has grown dramatically over the last several years. Biodiesel standards vary across countries and regions, and there is a call for harmonization. For harmonization to become a reality, standards have to be adapted to cover all feedstocks. Additionally, all feedstocks cannot meet all specifications, so harmonization will require standards to either tighten or relax. For harmonization to succeed, the biodiesel market must be expanded with the alignment of test methods and specification limits, not contracted.

  8. Lidar base specification

    USGS Publications Warehouse

    Heidemann, Hans Karl.

    2012-01-01

    Lidar is a fast evolving technology, and much has changed in the industry since the final draft of the “Lidar Base Specification Version 1.0” was written. Lidar data have improved in accuracy and spatial resolution, geospatial accuracy standards have been revised by the American Society for Photogrammetry and Remote Sensing (ASPRS), industry standard file formats have been expanded, additional applications for lidar have become accepted, and the need for interoperable data across collections has been realized. This revision to the “Lidar Base Specification Version 1.0” publication addresses those changes and provides continued guidance towards a nationally consistent lidar dataset.

  9. Screening for Specific Phobias

    MedlinePlus

    ... Screening for Posttraumatic Stress Disorder (PTSD) Screening for Social Anxiety Disorder Screening for Specific Phobias Screening for an Anxiety Disorder: Children Screening for an Anxiety Disorder: Family Member Self-Help Strategies: Webinars to Calm Anxious Minds "Triumph" E-News ...

  10. Task-specific Dystonias

    PubMed Central

    Torres-Russotto, Diego; Perlmutter, Joel S.

    2009-01-01

    Task-specific dystonias are primary focal dystonias characterized by excessive muscle contractions producing abnormal postures during selective motor activities that often involve highly skilled, repetitive movements. Historically these peculiar postures were considered psychogenic but have now been classified as forms of dystonia. Writer’s cramp is the most commonly identified task-specific dystonia and has features typical of this group of disorders. Symptoms may begin with lack of dexterity during performance of a specific motor task with increasingly abnormal posturing of the involved body part as motor activity continues. Initially, the dystonia may manifest only during the performance of the inciting task, but as the condition progresses it may also occur during other activities or even at rest. Neurological exam is usually unremarkable except for the dystonia-related abnormalities. Although the precise pathophysiology remains unclear, increasing evidence suggests reduced inhibition at different levels of the sensorimotor system. Symptomatic treatment options include oral medications, botulinum toxin injections, neurosurgical procedures, and adaptive strategies. Prognosis may vary depending upon body part involved and specific type of task affected. Further research may reveal new insights into the etiology, pathophysiology, natural history, and improved treatment of these conditions. PMID:18990127

  11. Component-specific modeling

    NASA Technical Reports Server (NTRS)

    Hirschbein, M. S.

    1982-01-01

    The ability to accurately structurally analyze engine components to assure that they can survive for their designed lifetime in an increasingly harsh environment is discussed. Under the HOST (HOt Section Technology) program, advanced component-specific modeling methods, with built-in analysis capability, will be developed separately for burner liners, turbine blades and vanes. These modeling methods will make maximum use of, but will not rely solely on, existing analysis methods and techniques, to analyze the three identified components. Nor will the complete structural analysis of a component necessarily be performed as a single analysis. The approach to be taken will develop complete software analysis packages with internal, component-specific, self-adaptive solution strategies. Each package will contain a set of modeling and analysis tools. The selection and order of specific methods and techniques within the set to be applied will depend on the specific-component, the current thermo-mechanical loading, and the current state of the component. All modeling and analysis decisions will be made internally based on developed decision criteria within the solution strategies; minimal user intervention will be required.

  12. IDC System Specification Document.

    SciTech Connect

    Clifford, David J.

    2014-12-01

    This document contains the system specifications derived to satisfy the system requirements found in the IDC System Requirements Document for the IDC Reengineering Phase 2 project. Revisions Version Date Author/Team Revision Description Authorized by V1.0 12/2014 IDC Reengineering Project Team Initial delivery M. Harris

  13. Facilities Specifications Guide.

    ERIC Educational Resources Information Center

    Athletic Business, 2000

    2000-01-01

    Provides line drawings of indoor and outdoor sporting fields reflecting the specifications and dimensional standards of each, including where additional information can be found. Sporting events from badminton, baseball, and basketball to lacrosse, swimming/diving, and volleyball are addressed. (GR)

  14. ENVIRONMENTAL SPECIFICATION REQUIREMENTS

    SciTech Connect

    TIFFT, S.R.

    2003-10-07

    Through regulations, permitting or binding negotiations, Regulators establish requirements, limits, permit conditions and Notice of Construction (NOC) conditions with which the Office of River Protection (ORP) and the Tank Farm Contractor (TFC) must comply. Operating Specifications are technical limits which are set on a process to prevent injury to personnel, or damage to the facility or environment. The main purpose of this document is to provide specification limits and recovery actions for the TFC Environmental Surveillance Program at the Hanford Site. Specification limits are given for monitoring frequencies and permissible variation of readings from an established baseline or previous reading. The requirements in this document are driven by environmental considerations and data analysis issues, rather than facility design or personnel safety issues. This document is applicable to all single-shell tank (SST) and double-shell tank (DST) waste tanks, and the associated catch tanks and receiver tanks, and transfer systems. This Tank Farm Environmental Specifications Document (ESD) implements environmental-regulatory limits on the configuration and operation of the Hanford Tank Farms facility that have been established by Regulators. This ESD contains specific field operational limits and recovery actions for compliance with airborne effluent regulations and agreements, liquid effluents regulations and agreements, and environmental tank system requirements. The scope of this ESD is limited to conditions that have direct impact on Operations Projects or that Operations/Projects have direct impact upon. This document does not supercede or replace any DOE Orders, regulatory permits, notices of construction, or Regulatory agency agreements binding on the ORP or the TFC. Refer to the appropriate regulation, permit, or NOC for an inclusive listing of requirements.

  15. [Pregnancy-specific dermatoses].

    PubMed

    Soutou, B; Aractingi, S

    2015-03-01

    Pregnancy-specific dermatoses include polymorphic eruption of pregnancy, atopic eczema of pregnancy, and pemphigoid gestationis. Intrahepatic cholestasis of pregnancy and impetigo herpetiformis are not real pregnancy-specific dermatoses but they are important to know considering the fetal and maternal risks. Polymorphic eruption of pregnancy is a pruritic disease that usually occurs in primiparous women during the last trimester of pregnancy. Atopic eczema of pregnancy is still controversial as an entity covering conditions with eczematous lesions, prurigo, or folliculitis, and inconstantly associated with a personal history of atopy. Skin biopsy with direct immunofluorescence or search for serum anti-BPAg1 (180kD) NC16a antibodies is mandatory in pruritic dermatoses of pregnancy in order to rule out pemphigoid gestationis. Serum bile salts levels should be tested whenever a generalized pruritus develops during pregnancy in order to rule out intrahepatic cholestasis. PMID:25194221

  16. SPECIFIC HEAT INDICATOR

    DOEpatents

    Horn, F.L.; Binns, J.E.

    1961-05-01

    Apparatus for continuously and automatically measuring and computing the specific heat of a flowing solution is described. The invention provides for the continuous measurement of all the parameters required for the mathematical solution of this characteristic. The parameters are converted to logarithmic functions which are added and subtracted in accordance with the solution and a null-seeking servo reduces errors due to changing voltage drops to a minimum. Logarithmic potentiometers are utilized in a unique manner to accomplish these results.

  17. NOSS altimeter algorithm specifications

    NASA Technical Reports Server (NTRS)

    Hancock, D. W.; Forsythe, R. G.; Mcmillan, J. D.

    1982-01-01

    A description of all algorithms required for altimeter processing is given. Each description includes title, description, inputs/outputs, general algebraic sequences and data volume. All required input/output data files are described and the computer resources required for the entire altimeter processing system were estimated. The majority of the data processing requirements for any radar altimeter of the Seasat-1 type are scoped. Additions and deletions could be made for the specific altimeter products required by other projects.

  18. ENVIRONMENTAL SPECIFICATION REQUIREMENTS

    SciTech Connect

    TIFFT, S.R.

    2003-11-03

    Through regulations, permitting or binding negotiations, Regulators establish requirements, limits, permit conditions and Notice of Construction (NOC) conditions with which the Office of River Protection (ORP) and the Tank Farm Contractor (TFC) must comply. Operating Specifications are technical limits which are set on a process to prevent injury to personnel, or damage to the facility or environment. The main purpose of this document is to provide specification limits and recovery actions for the TFC Environmental Surveillance Program at the Hanford Site. Specification limits are given for monitoring frequencies and permissible variation of readings from an established baseline or previous reading. The requirements in this document are driven by environmental considerations and data analysis issues, rather than facility design or personnel safety issues. This document is applicable to all SST and DST waste tanks, and the associated catch tanks and receiver tanks, and transfer systems. This Tank Farm ESD implements environmental-regulatory limits on the configuration and operation of the Hanford Tank Farms facility that have been established by Regulators. This ESD contains specific field operational limits and recovery actions for compliance with airborne effluent regulations and agreements, liquid effluents regulations and agreements, and environmental tank system requirements. The scope of this ESD is limited to conditions that have direct impact on Operations/Projects or that Operations/Projects have direct impact upon. This document does not supercede or replace any DOE Orders, regulatory permits, notices of construction, or Regulatory agency agreements binding on the ORP or the TFC. Refer to the appropriate regulation, permit, or NOC for an inclusive listing of requirements.

  19. Development of high performance precast/prestressed bridge girders

    NASA Astrophysics Data System (ADS)

    Akhnoukh, Amin K.

    Demand continues to increase for bridges with long spans and shallow depths. Due to safety concerns, four-span overpasses are being replaced with two span overpasses to avoid placement of piers near the highway shoulders. In the meantime, the bridge profile is restricted due to existing businesses nearby. Thus, nearly the same superstructure depth must be used for double the span length. This dissertation focuses on topics aiming at providing precast prestressed concrete girders with the shallowest possible depth for a given span. It forms parts of larger projects conducted by the University of Nebraska for the Nebraska Department of Roads and for the Wire Reinforcement Institute. Specifically, the following issues were researched: (1) Use of 0.7 in. diameter Grade 270 ksi strands for pretensioning of precast concrete girders at a strand spacing of 2 inches by 2 inches. This arrangement gives nearly 190 percent of the prestressing with 0.5 in. diameter strands and nearly 135 percent with 0.6 in. strands. The research focuses on the required confinement steel to allow determination of transfer and development lengths according to current procedures in the AASHTO LRFD Bridge Design Specifications for smaller strands. (2) Develop a self consolidating concrete (SCC) mix, using Nebraska aggregates that will allow for a specified design strength at service of 15 ksi and a minimum strength at one day of 10 ksi, representing the demand at the time of release of the prestress to the concrete member. Prior to this study, standard concrete strength prevailing in Nebraska has been 8 ksi at service and 6.5 ksi at release. It was the goal of the research to keep the cost of materials as low as possible but not exceeding 250 per cubic yard, compared to the proprietary mixes that cost approximately four times this amount. (3) Use of 80 ksi welded wire reinforcement (WWR) as the auxiliary reinforcement for shear, web end splitting and flange confinement. This would result in higher

  20. Data specifications for INSPIRE

    NASA Astrophysics Data System (ADS)

    Portele, Clemens; Woolf, Andrew; Cox, Simon

    2010-05-01

    In Europe a major recent development has been the entering in force of the INSPIRE Directive in May 2007, establishing an infrastructure for spatial information in Europe to support Community environmental policies, and policies or activities which may have an impact on the environment. INSPIRE is based on the infrastructures for spatial information established and operated by the 27 Member States of the European Union. The Directive addresses 34 spatial data themes needed for environmental applications, with key components specified through technical implementing rules. This makes INSPIRE a unique example of a legislative "regional" approach. One of the requirements of the INSPIRE Directive is to make existing spatial data sets with relevance for one of the spatial data themes available in an interoperable way, i.e. where the spatial data from different sources in Europe can be combined to a coherent result. Since INSPIRE covers a wide range of spatial data themes, the first step has been the development of a modelling framework that provides a common foundation for all themes. This framework is largely based on the ISO 19100 series of standards. The use of common generic spatial modelling concepts across all themes is an important enabler for interoperability. As a second step, data specifications for the first set of themes has been developed based on the modelling framework. The themes include addresses, transport networks, protected sites, hydrography, administrative areas and others. The data specifications were developed by selected experts nominated by stakeholders from all over Europe. For each theme a working group was established in early 2008 working on their specific theme and collaborating with the other working groups on cross-theme issues. After a public review of the draft specifications starting in December 2008, an open testing process and thorough comment resolution process, the draft technical implementing rules for these themes have been

  1. Component-specific modeling

    NASA Technical Reports Server (NTRS)

    Mcknight, R. L.

    1985-01-01

    A series of interdisciplinary modeling and analysis techniques that were specialized to address three specific hot section components are presented. These techniques will incorporate data as well as theoretical methods from many diverse areas including cycle and performance analysis, heat transfer analysis, linear and nonlinear stress analysis, and mission analysis. Building on the proven techniques already available in these fields, the new methods developed will be integrated into computer codes to provide an accurate, and unified approach to analyzing combustor burner liners, hollow air cooled turbine blades, and air cooled turbine vanes. For these components, the methods developed will predict temperature, deformation, stress and strain histories throughout a complete flight mission.

  2. Component-specific modeling

    NASA Technical Reports Server (NTRS)

    Mcknight, R. L.

    1985-01-01

    Accomplishments are described for the second year effort of a 3-year program to develop methodology for component specific modeling of aircraft engine hot section components (turbine blades, turbine vanes, and burner liners). These accomplishments include: (1) engine thermodynamic and mission models; (2) geometry model generators; (3) remeshing; (4) specialty 3-D inelastic stuctural analysis; (5) computationally efficient solvers, (6) adaptive solution strategies; (7) engine performance parameters/component response variables decomposition and synthesis; (8) integrated software architecture and development, and (9) validation cases for software developed.

  3. Specifications Physiological Monitoring System

    NASA Technical Reports Server (NTRS)

    1985-01-01

    The operation of a physiological monitoring system (PMS) is described. Specifications were established for performance, design, interface, and test requirements. The PMS is a compact, microprocessor-based system, which can be worn in a pack on the body or may be mounted on a Spacelab rack or other appropriate structure. It consists of two modules, the Data Control Unit (DCU) and the Remote Control/Display Unit (RCDU). Its purpose is to collect and distribute data from physiological experiments in the Spacelab and in the Orbiter.

  4. Master Software Requirements Specification

    NASA Technical Reports Server (NTRS)

    Hu, Chaumin

    2003-01-01

    A basic function of a computational grid such as the NASA Information Power Grid (IPG) is to allow users to execute applications on remote computer systems. The Globus Resource Allocation Manager (GRAM) provides this functionality in the IPG and many other grids at this time. While the functionality provided by GRAM clients is adequate, GRAM does not support useful features such as staging several sets of files, running more than one executable in a single job submission, and maintaining historical information about execution operations. This specification is intended to provide the environmental and software functional requirements for the IPG Job Manager V2.0 being developed by AMTI for NASA.

  5. Specific construction tests

    NASA Technical Reports Server (NTRS)

    Mcrae, W. V., Jr.

    1980-01-01

    The technical feasibility of the Satellite Power System (SPS) is discussed. The development of feasible operational concepts and conceptualization of specific construction tasks are examined. The logic flow of functional analyses of both the rectenna and the satellite is illustrated. Constraints placed upon the construction processes and equipment by the satellite design are outlined. The construction tasks, when defined and combined into an integrated schedule establish, a time line for construction mass flow demands to be satisfied by the space transportation systems. An example of satellite constructive demands and HLLV delivery capabilities is given.

  6. 310 Facility chemical specifications

    SciTech Connect

    Hagerty, K.J.

    1997-05-21

    The 300 area Treated Effluent Disposal Facility (TEDF) was designed and built to treat the waste water from the 300 area process sewer system. Several treatment technologies are employed to remove the trace quantities of contaminants in the stream, including iron coprecipitation, clarification, filtration, ion exchange, and ultra violet light/hydrogen peroxide oxidation of organics. The chemicals that will be utilized in the treatment process are hydrogen peroxide, sulfuric acid, sodium hydroxide, and ferric chloride. This document annotates the required chemical characteristics of TEDF bulk chemicals as well as the criteria that were used to establish these criteria. The chemical specifications in appendix B are generated from this information.

  7. General Environmental Verification Specification

    NASA Technical Reports Server (NTRS)

    Milne, J. Scott, Jr.; Kaufman, Daniel S.

    2003-01-01

    The NASA Goddard Space Flight Center s General Environmental Verification Specification (GEVS) for STS and ELV Payloads, Subsystems, and Components is currently being revised based on lessons learned from GSFC engineering and flight assurance. The GEVS has been used by Goddard flight projects for the past 17 years as a baseline from which to tailor their environmental test programs. A summary of the requirements and updates are presented along with the rationale behind the changes. The major test areas covered by the GEVS include mechanical, thermal, and EMC, as well as more general requirements for planning, tracking of the verification programs.

  8. VOST charcoal specification study

    SciTech Connect

    Fuerst, R.G.; Foster, A.L.; Bursey, J.T.

    1996-12-31

    The volatile organic sampling train (VOST) is currently one the leading methodologies available for the sampling and analysis of volatile principal organic hazardous constituents (POHCs) and products of incomplete combustion (PICs) from stationary sources at very low levels. However, revisions to the original method are necessary to maintain VOST as a viable regulatory tool. To provide performance specifications and identify a replacement for SKC Lot 104 charcoal, a VOST charcoal specification study was initiated. The following carbon-based candidate sorbents were considered: Tenax-GR (a graphitized Tenax); a Petroleum-based Charcoal; Ambersorbe XE-340 (hydrophobic carbonized resin bead); Anasorb 747 (beaded active carbon with very regular pore size); Carbosieve{reg_sign} S-III (carbon molecular sieve); and a Beaded Activated Charcoal (BAC) (with a very regular pore size). The results indicated that Tenax-GR showed significantly poorer performance than the other candidates in preliminary experimental results. Ambersorb did not retain the gaseous volatile organic compounds tested as well as the others and recovery of vinyl chloride was very low at all levels of spiking. Carbosieve was eliminated as a candidate replacement because of cost and handling problems. The petroleum-based charcoal was eliminated because of difficulties in handling a finely-divided powder. The availability of Anasorb 747 proved to be the deciding factor between it and the BAC. Performance, cost, ease of handling, and plentiful supply make Anasorb{reg_sign} 747 a good choice for replacement of SKC Lot 104. 1 tab.

  9. Component-specific modeling

    NASA Technical Reports Server (NTRS)

    Mcknight, R. L.

    1984-01-01

    A series of interdisciplinary modeling and analysis techniques that were specialized to address three specific hot section components are presented. These techniques will incorporate data as well as theoretical methods from many diverse areas including cycle and performance analysis, heat transfer analysis, linear and nonlinear stress analysis, and mission analysis. Building on the proven techniques already available in these fields, the new methods developed will be integrated into computer codes to provide an accurate, efficient and unified approach to analyzing combustor burner liners, hollow air-cooled turbine blades and air-cooled turbine vanes. For these components, the methods developed will predict temperature, deformation, stress and strain histories throughout a complete flight mission.

  10. A specific hygiene hypothesis.

    PubMed

    Shunsheng Han, Cliff

    2016-08-01

    Allergic diseases have reached epidemic proportions in Western populations in the last several decades. The hygiene hypothesis proposed more than twenty years ago has helped us to understand the epidemic and has been verified with numerous studies. However, translational measures deduced from these studies to prevent allergic diseases have not proven effective. Recent studies on immigrants' allergies and any potential association between oral infection and allergic diseases prompt me to propose a specific hygiene hypothesis to explain how oral hygiene practices might have contributed to the uprising of hay fever, the most common allergic disease. The historic oral hygiene level in US is closely associated with the emerging allergic epidemic. Future studies to test the hypothesis are needed and verification of the hypothesis can potentially yield highly effective measures to prevent allergic diseases. PMID:27372876

  11. Cylinder Test Specification

    SciTech Connect

    Richard Catanach; Larry Hill; Herbert Harry; Ernest Aragon; Don Murk

    1999-10-01

    The purpose of the cylinder testis two-fold: (1) to characterize the metal-pushing ability of an explosive relative to that of other explosives as evaluated by the E{sub 19} cylinder energy and the G{sub 19} Gurney energy and (2) to help establish the explosive product equation-of-state (historically, the Jones-Wilkins-Lee (JWL) equation). This specification details the material requirements and procedures necessary to assemble and fire a typical Los Alamos National Laboratory (LANL) cylinder test. Strict adherence to the cylinder. material properties, machining tolerances, material heat-treatment and etching processes, and high explosive machining tolerances is essential for test-to-test consistency and to maximize radial wall expansions. Assembly and setup of the cylinder test require precise attention to detail, especially when placing intricate pin wires on the cylinder wall. The cylinder test is typically fired outdoors and at ambient temperature.

  12. Site-specific photochemistry

    NASA Astrophysics Data System (ADS)

    Koplitz, Brent D.; Brum, Jeffrey L.; Deshmukh, Subhash; Xu, Xiaodong; Wang, Zhongrui; Yen, Yu-Fong

    1992-04-01

    We present results on `site-specific' H-atom production in photolysis experiments conducted under collisionless conditions. H and D atoms are used as labels to investigate the site(s) at which C-H (or C-D) bond cleavage occurs in a variety of haloalkane systems. Experiments using two photolysis lasers clearly indicate that photon absorption by an intermediate, presumably an alkyl radical, is important in many of the systems studied. The site(s) (e.g., (alpha) , (beta) , or (gamma) ) at which C-H (or C-D) bond cleavage occurs is dependent not only on the nature of the molecule, but also on the photolysis wavelength. As a diagnostic tool, H- and D-atom Doppler spectroscopy allows us to gain insight into the energetics associated with the various dissociation processes. Our overall aim is to gain a further understanding of the photolysis properties of a variety of simple molecules and their associated radicals.

  13. Intent Specifications: An Approach to Building Human-Centered Specifications

    NASA Technical Reports Server (NTRS)

    Leveson, Nancy G.

    1999-01-01

    This paper examines and proposes an approach to writing software specifications, based on research in systems theory, cognitive psychology, and human-machine interaction. The goal is to provide specifications that support human problem solving and the tasks that humans must perform in software development and evolution. A type of specification, called intent specifications, is constructed upon this underlying foundation.

  14. ADANS database specification

    SciTech Connect

    1997-01-16

    The purpose of the Air Mobility Command (AMC) Deployment Analysis System (ADANS) Database Specification (DS) is to describe the database organization and storage allocation and to provide the detailed data model of the physical design and information necessary for the construction of the parts of the database (e.g., tables, indexes, rules, defaults). The DS includes entity relationship diagrams, table and field definitions, reports on other database objects, and a description of the ADANS data dictionary. ADANS is the automated system used by Headquarters AMC and the Tanker Airlift Control Center (TACC) for airlift planning and scheduling of peacetime and contingency operations as well as for deliberate planning. ADANS also supports planning and scheduling of Air Refueling Events by the TACC and the unit-level tanker schedulers. ADANS receives input in the form of movement requirements and air refueling requests. It provides a suite of tools for planners to manipulate these requirements/requests against mobility assets and to develop, analyze, and distribute schedules. Analysis tools are provided for assessing the products of the scheduling subsystems, and editing capabilities support the refinement of schedules. A reporting capability provides formatted screen, print, and/or file outputs of various standard reports. An interface subsystem handles message traffic to and from external systems. The database is an integral part of the functionality summarized above.

  15. Specific language impairment.

    PubMed

    Kamhi, Alan G; Clark, Mary Kristen

    2013-01-01

    The acquisition of language is one of the most important achievements in young children, in part because most children appear to acquire language with little effort. Some children are not so fortunate, however. There is a large group of children who also have difficulty learning language, but do not have obvious neurological, cognitive, sensory, emotional, or environmental deficits. Clinicians often refer to these children as language disordered or language impaired. Researchers tend to refer to these children as specific language impaired (SLI). Children with SLI have intrigued researchers for many years because there is no obvious reason for their language learning difficulties. SLI has been found to be an enduring condition that begins in early childhood and often persists into adolescence and adulthood. The language problems of children with SLI are not limited to spoken language; they also affect reading and writing and thus much of academic learning. Knowledge of the characteristics of SLI should aid physicians, pediatricians, and early childhood specialists to identify these children during the preschool years and ensure that they receive appropriate services. With high-quality language intervention and literacy instruction, most children with SLI should be able to perform and function adequately in school and beyond. PMID:23622167

  16. Genotype Specification Language.

    PubMed

    Wilson, Erin H; Sagawa, Shiori; Weis, James W; Schubert, Max G; Bissell, Michael; Hawthorne, Brian; Reeves, Christopher D; Dean, Jed; Platt, Darren

    2016-06-17

    We describe here the Genotype Specification Language (GSL), a language that facilitates the rapid design of large and complex DNA constructs used to engineer genomes. The GSL compiler implements a high-level language based on traditional genetic notation, as well as a set of low-level DNA manipulation primitives. The language allows facile incorporation of parts from a library of cloned DNA constructs and from the "natural" library of parts in fully sequenced and annotated genomes. GSL was designed to engage genetic engineers in their native language while providing a framework for higher level abstract tooling. To this end we define four language levels, Level 0 (literal DNA sequence) through Level 3, with increasing abstraction of part selection and construction paths. GSL targets an intermediate language based on DNA slices that translates efficiently into a wide range of final output formats, such as FASTA and GenBank, and includes formats that specify instructions and materials such as oligonucleotide primers to allow the physical construction of the GSL designs by individual strain engineers or an automated DNA assembly core facility. PMID:26886161

  17. Specification-Based Testing Via Domain Specific Language

    NASA Astrophysics Data System (ADS)

    Sroka, Michal; Nagy, Roman; Fisch, Dominik

    2014-12-01

    The article presents tCF (testCaseFramework) - a domain specific language with corresponding toolchain for specification-based software testing of embedded software. tCF is designed for efficient preparation of maintainable and intelligible test cases and for testing process automation, as it allows to generate platform specific test cases for various testing levels. The article describes the essential parts of the tCF meta-model and the applied concept of platform specific test cases generators.

  18. Specificity and non-specificity in RNA–protein interactions

    PubMed Central

    Jankowsky, Eckhard; Harris, Michael E.

    2016-01-01

    Gene expression is regulated by complex networks of interactions between RNAs and proteins. Proteins that interact with RNA have been traditionally viewed as either specific or non-specific; specific proteins interact preferentially with defined RNA sequence or structure motifs, whereas non-specific proteins interact with RNA sites devoid of such characteristics. Recent studies indicate that the binary “specific vs. non-specific” classification is insufficient to describe the full spectrum of RNA–protein interactions. Here, we review new methods that enable quantitative measurements of protein binding to large numbers of RNA variants, and the concepts aimed as describing resulting binding spectra: affinity distributions, comprehensive binding models and free energy landscapes. We discuss how these new methodologies and associated concepts enable work towards inclusive, quantitative models for specific and non-specific RNA–protein interactions. PMID:26285679

  19. Compositional Specification of Software Architecture

    NASA Technical Reports Server (NTRS)

    Penix, John; Lau, Sonie (Technical Monitor)

    1998-01-01

    This paper describes our experience using parameterized algebraic specifications to model properties of software architectures. The goal is to model the decomposition of requirements independent of the style used to implement the architecture. We begin by providing an overview of the role of architecture specification in software development. We then describe how architecture specifications are build up from component and connector specifications and give an overview of insights gained from a case study used to validate the method.

  20. Variola Virus-Specific Diagnostic Assays: Characterization, Sensitivity, and Specificity

    PubMed Central

    Kondas, Ashley V.; Olson, Victoria A.; Li, Yu; Abel, Jason; Laker, Miriam; Rose, Laura; Wilkins, Kimberly; Turner, Jonathan; Kline, Richard

    2015-01-01

    A public health response relies upon rapid and reliable confirmation of disease by diagnostic assays. Here, we detail the design and validation of two variola virus-specific real-time PCR assays, since previous assays cross-reacted with newly identified cowpox viruses. The assay specificity must continually be reassessed as other closely related viruses are identified. PMID:25673790

  1. Standard Specifications for Language Laboratory.

    ERIC Educational Resources Information Center

    North Carolina State Dept. of Administration, Raleigh.

    Specifications are presented covering the components of electronic and electro-mechanical equipment, non-electrical materials for the teacher-student positions, and other items of a miscellaneous nature to provide for a complete, workable language laboratory facility. Instructions for the use of specifications are included for the purchaser,…

  2. Response to "Transfer or Specificity?"

    ERIC Educational Resources Information Center

    Miller, Judith

    2007-01-01

    This article presents the author's response to "Transfer or Specificity?" and reports a research that supports a strong case for a fundamental motor skill as a precursor to two sport specific skills as in Gallahue and Ozmun's (2002) theoretical model of motor development. Reported changes in performance of the overarm throw are attributed to the…

  3. Technical Specifications. Revision No. 1.

    ERIC Educational Resources Information Center

    Mississippi State Dept. of Education, Jackson. Office of Educational Technology.

    The technical specifications for educational technology in the state of Mississippi which are contained in this publication represent the minimum criteria for utilization of the equipment. Information is provided for PC (personal computer) and Macintosh platforms where applicable on: workstation specifications; multimedia/teacher presentation…

  4. Hanford Site environmental management specification

    SciTech Connect

    Grygiel, M.L.

    1998-06-10

    The US Department of Energy, Richland Operations Office (RL) uses this Hanford Site Environmental Management Specification (Specification) to document top-level mission requirements and planning assumptions for the prime contractors involved in Hanford Site cleanup and infrastructure activities under the responsibility of the US Department of Energy, Office of Environmental Management. This Specification describes at a top level the activities, facilities, and infrastructure necessary to accomplish the cleanup of the Hanford Site and assigns this scope to Site contractors and their respective projects. This Specification also references the key National Environmental Policy Act of 1969 (NEPA), Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA), and safety documentation necessary to accurately describe the cleanup at a summary level. The information contained in this document reflects RL`s application of values, priorities, and critical success factors expressed by those involved with and affected by the Hanford Site project. The prime contractors and their projects develop complete baselines and work plans to implement this Specification. These lower-level documents and the data that support them, together with this Specification, represent the full set of requirements applicable to the contractors and their projects. Figure 1-1 shows the relationship of this Specification to the other basic Site documents. Similarly, the documents, orders, and laws referenced in this specification represent only the most salient sources of requirements. Current and contractual reference data contain a complete set of source documents.

  5. Performance Specifications for Occupational Programs.

    ERIC Educational Resources Information Center

    Maryland State Dept. of Education, Baltimore. Div. of Career Technology and Adult Learning.

    This document lists and discusses the development of Maryland's performance specifications for occupational programs. The introduction explains the process used to develop performance standards and specifications for 10 career cluster majors that were identified by a task force of educators and employers as high-demand occupational areas in…

  6. The Development of Educational Specifications.

    ERIC Educational Resources Information Center

    North Carolina State Board of Education, Raleigh.

    This publication is intended to assist local boards of education, superintendents, and staff in the organization and development of educational specifications. It was written because most educators have little knowledge about the purpose, process, organization, or contents of the finished product (educational specifications). It provides a…

  7. PROPOSED SPECIFICATIONS FOR INERTIAL SURVEYING.

    USGS Publications Warehouse

    Chapman, William H.

    1983-01-01

    The purpose of this paper is to continue the movement toward placing inertial surveying instruments in the toolbox of the geodetic surveyor. A set of specifications is proposed for performing horizontal geodetic surveys with inertial instruments that will meet the Federal Geodetic Control Committee (FGCC) second- and third-order standards. These specifications are tentative.

  8. Standard technical specifications, Westinghouse Plants: Specifications. Volume 1, Revision 1

    SciTech Connect

    1995-04-01

    This NUREG contains the improved Standard Technical Specifications (STS) for Westinghouse plants. Revision 1 incorporates the cumulative changes to Revision 0, which was published in September 1992. The changes reflected in Revision 1 resulted from the experience gained from license amendment applications to convert to these improved STS or to adopt partial improvements to existing technical specifications. This NUREG is the result of extensive public technical meetings and discussions between the Nuclear Regulatory Commission (NRC) staff and various nuclear power plant licensees, Nuclear Steam Supply System (NSSS) Owners Groups, specifically the Westinghouse Owners Group (WOG), NSSS vendors, and the Nuclear Energy Institute (NEI). The improved STS were developed based on the criteria in the Final Commission Policy Statement on Technical Specifications Improvements for Nuclear Power Reactors, dated July 22, 1993 (58 FR 39132). Licensees are encouraged to upgrade their technical specifications consistent with those criteria and conforming, to the extent practical and consistent with the licensing basis for the facility, to Revision 1 to the improved STS. The Commission continues to place the highest priority on requests for complete conversions to the improved STS. Licensees adopting portions of the improved STS to existing technical specifications should adopt all related requirements, as applicable, to achieve a high degree of standardization and consistency.

  9. Information capacity of specific interactions.

    PubMed

    Huntley, Miriam H; Murugan, Arvind; Brenner, Michael P

    2016-05-24

    Specific interactions are a hallmark feature of self-assembly and signal-processing systems in both synthetic and biological settings. Specificity between components may arise from a wide variety of physical and chemical mechanisms in diverse contexts, from DNA hybridization to shape-sensitive depletion interactions. Despite this diversity, all systems that rely on interaction specificity operate under the constraint that increasing the number of distinct components inevitably increases off-target binding. Here we introduce "capacity," the maximal information encodable using specific interactions, to compare specificity across diverse experimental systems and to compute how specificity changes with physical parameters. Using this framework, we find that "shape" coding of interactions has higher capacity than chemical ("color") coding because the strength of off-target binding is strongly sublinear in binding-site size for shapes while being linear for colors. We also find that different specificity mechanisms, such as shape and color, can be combined in a synergistic manner, giving a capacity greater than the sum of the parts. PMID:27155013

  10. SSL: A software specification language

    NASA Technical Reports Server (NTRS)

    Austin, S. L.; Buckles, B. P.; Ryan, J. P.

    1976-01-01

    SSL (Software Specification Language) is a new formalism for the definition of specifications for software systems. The language provides a linear format for the representation of the information normally displayed in a two-dimensional module inter-dependency diagram. In comparing SSL to FORTRAN or ALGOL, it is found to be largely complementary to the algorithmic (procedural) languages. SSL is capable of representing explicitly module interconnections and global data flow, information which is deeply imbedded in the algorithmic languages. On the other hand, SSL is not designed to depict the control flow within modules. The SSL level of software design explicitly depicts intermodule data flow as a functional specification.

  11. Electric motor model repair specifications

    SciTech Connect

    1995-08-01

    These model repair specifications list the minimum requirements for repair and overhaul of polyphase AC squireel cage induction motors. All power ranges, voltages, and speeds of squirrel cage motors are covered.

  12. Molecular Mechanisms of Synaptic Specificity

    PubMed Central

    Margeta, Milica A.; Shen, Kang

    2011-01-01

    Synapses are specialized junctions that mediate information flow between neurons and their targets. A striking feature of the nervous system is the specificity of its synaptic connections: an individual neuron will form synapses only with a small subset of available presynaptic and postsynaptic partners. Synaptic specificity has been classically thought to arise from homophilic or heterophilic interactions between adhesive molecules acting across the synaptic cleft. Over the past decade, many new mechanisms giving rise to synaptic specificity have been identified. Synapses can be specified by secreted molecules that promote or inhibit synaptogenesis, and their source can be a neighboring guidepost cell, not just presynaptic and postsynaptic neurons. Furthermore, lineage, fate, and timing of development can also play critical roles in shaping neural circuits. Future work utilizing large-scale screens will aim to elucidate the full scope of cellular mechanisms and molecular players that can give rise to synaptic specificity. PMID:19969086

  13. Grade 6 Science Curriculum Specifications.

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Curriculum Branch.

    This material describes curriculum specifications for grade 6 science in Alberta. Emphases recommended are: (1) process skills (50%); (2) psychomotor skills (10%); (3) attitudes (10%); and (4) subject matter (30%). Priorities within each category are identified. (YP)

  14. Specification of pyro shock tests

    NASA Technical Reports Server (NTRS)

    Trummel, M.

    1976-01-01

    Specifications of pyro shock tests are treated as the interconnection between raw measurements (or estimates) of the environment and the various test methods available. After a definition of the environment, various aspects of test method specification are discussed including one-sided pulses, test simulation parameters, and the effects of Q. Different test configurations are considered including rigid fixture tests, pseudo-real structure, and real structure.

  15. mREST Interface Specification

    NASA Technical Reports Server (NTRS)

    McCartney, Patrick; MacLean, John

    2012-01-01

    mREST is an implementation of the REST architecture specific to the management and sharing of data in a system of logical elements. The purpose of this document is to clearly define the mREST interface protocol. The interface protocol covers all of the interaction between mREST clients and mREST servers. System-level requirements are not specifically addressed. In an mREST system, there are typically some backend interfaces between a Logical System Element (LSE) and the associated hardware/software system. For example, a network camera LSE would have a backend interface to the camera itself. These interfaces are specific to each type of LSE and are not covered in this document. There are also frontend interfaces that may exist in certain mREST manager applications. For example, an electronic procedure execution application may have a specialized interface for configuring the procedures. This interface would be application specific and outside of this document scope. mREST is intended to be a generic protocol which can be used in a wide variety of applications. A few scenarios are discussed to provide additional clarity but, in general, application-specific implementations of mREST are not specifically addressed. In short, this document is intended to provide all of the information necessary for an application developer to create mREST interface agents. This includes both mREST clients (mREST manager applications) and mREST servers (logical system elements, or LSEs).

  16. Quantifying group specificity of animal vocalizations without specific sender information

    NASA Astrophysics Data System (ADS)

    Vester, Heike; Hammerschmidt, Kurt; Timme, Marc; Hallerberg, Sarah

    2016-02-01

    Recordings of animal vocalization can lack information about sender and context. This is often the case in studies on marine mammals or in the increasing number of automated bioacoustics monitorings. Here, we develop a framework to estimate group specificity without specific sender information. We introduce and apply a bag-of-calls-and-coefficients approach (BOCCA) to study ensembles of cepstral coefficients calculated from vocalization signals recorded from a given animal group. Comparing distributions of such ensembles of coefficients by computing relative entropies reveals group specific differences. Applying the BOCCA to ensembles of calls recorded from group of long-finned pilot whales in northern Norway, we find that differences of vocalizations within social groups of pilot whales (Globicephala melas) are significantly lower than intergroup differences.

  17. Quantifying group specificity of animal vocalizations without specific sender information.

    PubMed

    Vester, Heike; Hammerschmidt, Kurt; Timme, Marc; Hallerberg, Sarah

    2016-02-01

    Recordings of animal vocalization can lack information about sender and context. This is often the case in studies on marine mammals or in the increasing number of automated bioacoustics monitorings. Here, we develop a framework to estimate group specificity without specific sender information. We introduce and apply a bag-of-calls-and-coefficients approach (BOCCA) to study ensembles of cepstral coefficients calculated from vocalization signals recorded from a given animal group. Comparing distributions of such ensembles of coefficients by computing relative entropies reveals group specific differences. Applying the BOCCA to ensembles of calls recorded from group of long-finned pilot whales in northern Norway, we find that differences of vocalizations within social groups of pilot whales (Globicephala melas) are significantly lower than intergroup differences. PMID:26986319

  18. Velocity specificity, combination training and sport specific tasks.

    PubMed

    Cronin, J; McNair, P J; Marshall, R N

    2001-06-01

    Whether velocity-specific resistance training is important for improving functional sporting performance was investigated by studying the effect of isoinertial training velocity on netball chest pass throwing velocity. Twenty-one female netball players were randomly assigned to a strength-trained group (80% 1RM - average training velocity = .308 m/s), power-trained group (60% 1RM - average training velocity = .398 m/s) and a control group. Resistance training was combined with sport specific motion training for both groups over a ten-week training duration. Pre- and post-training testing revealed that the training velocity associated with the strength-trained group produced significantly greater improvement in mean volume of weight lifted (85kg) and mean power output (13.25 W) as compared to the power and control groups (P< 0.05). The strength-trained and power-trained groups significantly improved netball throw velocity by 12.4% and 8.8% respectively. There was no significant difference between the two groups. The validity of velocity-specific training and subsequent adaptations to improve functional sporting performance appears highly questionable, due to the disparity between training velocity and actual movement velocity (11.38 m x s(-1)) for a given sport specific task such as the netball throw it was proposed that the repeated intent to move an isoinertial load as rapidly as possible coupled with performance of the sport-specific movement promote efficient coordination and activation patterns. Such mechanisms might be more important determinants of sport-specific high velocity adaptation. PMID:11548916

  19. 1997 hybrid electric vehicle specifications

    SciTech Connect

    Sluder, S.; Larsen, R.; Duoba, M.

    1996-10-01

    The US DOE sponsors Advanced Vehicle Technology competitions to help educate the public and advance new vehicle technologies. For several years, DOE has provided financial and technical support for the American Tour de Sol. This event showcases electric and hybrid electric vehicles in a road rally across portions of the northeastern United States. The specifications contained in this technical memorandum apply to vehicles that will be entered in the 1997 American Tour de Sol. However, the specifications were prepared to be general enough for use by other teams and individuals interested in developing hybrid electric vehicles. The purpose of the specifications is to ensure that the vehicles developed do not present a safety hazard to the teams that build and drive them or to the judges, sponsors, or public who attend the competitions. The specifications are by no means the definitive sources of information on constructing hybrid electric vehicles - as electric and hybrid vehicles technologies advance, so will the standards and practices for their construction. In some cases, the new standards and practices will make portions of these specifications obsolete.

  20. Technical specification for vacuum systems

    SciTech Connect

    Khaw, J.

    1987-01-01

    The vacuum systems at the Stanford Linear Accelerator Center (SLAC) are primarily of all-metal construction and operate at pressures from 10/sup -5/ to 10/sup -11/ Torr. The primary gas loads during operation result from thermal desorption and beam-induced desorption from the vacuum chamber walls. These desorption rates can be extremely high in the case of hydrocarbons and other contaminants. These specifications place a major emphasis on eliminating contamination sources. The specifications and procedures have been written to insure the cleanliness and vacuum integrity of all SLAC vacuum systems, and to assist personnel involved with SLAC vacuum systems in choosing and designing components that are compatible with existing systems and meet the quality and reliability of SLAC vacuum standards. The specification includes requirements on design, procurement, fabrication, chemical cleaning, clean room practices, welding and brazing, helium leak testing, residual gas analyzer testing, bakeout, venting, and pumpdown. Also appended are specifications regarding acceptable vendors, isopropyl alcohol, bakeable valve cleaning procedure, mechanical engineering safety inspection, notes on synchrotron radiation, and specifications of numerous individual components. (LEW)

  1. Specificity of hammerhead ribozyme cleavage.

    PubMed Central

    Hertel, K J; Herschlag, D; Uhlenbeck, O C

    1996-01-01

    To be effective in gene inactivation, the hammerhead ribozyme must cleave a complementary RNA target without deleterious effects from cleaving non-target RNAs that contain mismatches and shorter stretches of complementarity. The specificity of hammerhead cleavage was evaluated using HH16, a well-characterized ribozyme designed to cleave a target of 17 residues. Under standard reaction conditions, HH16 is unable to discriminate between its full-length substrate and 3'-truncated substrates, even when six fewer base pairs are formed between HH16 and the substrate. This striking lack of specificity arises because all the substrates bind to the ribozyme with sufficient affinity so that cleavage occurs before their affinity differences are manifested. In contrast, HH16 does exhibit high specificity towards certain 3'-truncated versions of altered substrates that either also contain a single base mismatch or are shortened at the 5' end. In addition, the specificity of HH16 is improved in the presence of p7 nucleocapsid protein from human immunodeficiency virus (HIV)-1, which accelerates the association and dissociation of RNA helices. These results support the view that the hammerhead has an intrinsic ability to discriminate against incorrect bases, but emphasizes that the high specificity is only observed in a certain range of helix lengths. Images PMID:8670879

  2. Second Language Tests for Specific Purpose: How Specific?

    ERIC Educational Resources Information Center

    Ricciardi, Joseph S.

    1981-01-01

    This paper discusses certain problems that can arise with respect to the selection of content in the preparation of a test to measure language proficiency for some specific purpose. Forty employees in a defense plant in Montreal, Canada were interviewed in order to specify language needs, to arrive at a precise interpretation of the required…

  3. Compiler writing system detail design specification. Volume 1: Language specification

    NASA Technical Reports Server (NTRS)

    Arthur, W. J.

    1974-01-01

    Construction within the Meta language for both language and target machine specification is reported. The elements of the function language as a meaning and syntax are presented, and the structure of the target language is described which represents the target dependent object text representation of applications programs.

  4. Application specific serial arithmetic arrays

    NASA Technical Reports Server (NTRS)

    Winters, K.; Mathews, D.; Thompson, T.

    1990-01-01

    High performance systolic arrays of serial-parallel multiplier elements may be rapidly constructed for specific applications by applying hardware description language techniques to a library of full-custom CMOS building blocks. Single clock pre-charged circuits have been implemented for these arrays at clock rates in excess of 100 Mhz using economical 2-micron (minimum feature size) CMOS processes, which may be quickly configured for a variety of applications. A number of application-specific arrays are presented, including a 2-D convolver for image processing, an integer polynomial solver, and a finite-field polynomial solver.

  5. High specific heat superconducting composite

    DOEpatents

    Steyert, Jr., William A.

    1979-01-01

    A composite superconductor formed from a high specific heat ceramic such as gadolinium oxide or gadolinium-aluminum oxide and a conventional metal conductor such as copper or aluminum which are insolubly mixed together to provide adiabatic stability in a superconducting mode of operation. The addition of a few percent of insoluble gadolinium-aluminum oxide powder or gadolinium oxide powder to copper, increases the measured specific heat of the composite by one to two orders of magnitude below the 5.degree. K. level while maintaining the high thermal and electrical conductivity of the conventional metal conductor.

  6. Automotive Lubricant Specification and Testing

    NASA Astrophysics Data System (ADS)

    Fox, M. F.

    This chapter concerns commercial lubricant specification and testing, drawing together the many themes of previous chapters. Military lubricant standards were a very strong initial influence during World War II and led to the separate historical development of the North American and European specification systems. The wide range of functions that a successful lubricant must satisfy is discussed, together with issues of balancing special or universal applications, single or multiple engine tests, the philosophy of accelerated testing and the question of 'who sets the standards?' The role of engine tests and testing organisations is examined.

  7. Host Specificity of Bacterial Pathogens

    PubMed Central

    Bäumler, Andreas; Fang, Ferric C.

    2013-01-01

    Most pathogens are able to infect multiple hosts but some are highly adapted to a single-host species. A detailed understanding of the basis of host specificity can provide important insights into molecular pathogenesis, the evolution of pathogenic microbes, and the potential for pathogens to cross the species barrier to infect new hosts. Comparative genomics and the development of humanized mouse models have provided important new tools with which to explore the basis of generalism and specialism. This review will examine host specificity of bacterial pathogens with a focus on generalist and specialist serovars of Salmonella enterica. PMID:24296346

  8. Adaptive Assessments Using Open Specifications

    ERIC Educational Resources Information Center

    Leon, Hector Barbosa; Garcia-Penalvo, Francisco J.; Rodriguez-Conde, Maria Jose; Morales, Erla M.; de Pablos, Patricia Ordonez

    2012-01-01

    Evaluation is a key element in formal education processes; it must be constructed in a way that the item questions within help students understand by adapting them to the learning style as well. The focus of the present research work specifically in the convenience to adapt an associated multimedia material in each single question besides the…

  9. Reflight certification software design specifications

    NASA Technical Reports Server (NTRS)

    1984-01-01

    The PDSS/IMC Software Design Specification for the Payload Development Support System (PDSS)/Image Motion Compensator (IMC) is contained. The PDSS/IMC is to be used for checkout and verification of the IMC flight hardware and software by NASA/MSFC.

  10. 46 CFR Sec. 3 - Specifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false Specifications. Sec. 3 Section 3 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY PROCEDURE FOR ACCOMPLISHMENT OF VESSEL REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec....

  11. 46 CFR Sec. 3 - Specifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false Specifications. Sec. 3 Section 3 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY PROCEDURE FOR ACCOMPLISHMENT OF VESSEL REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec....

  12. 46 CFR Sec. 3 - Specifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Specifications. Sec. 3 Section 3 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY PROCEDURE FOR ACCOMPLISHMENT OF VESSEL REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec....

  13. 46 CFR Sec. 3 - Specifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false Specifications. Sec. 3 Section 3 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY PROCEDURE FOR ACCOMPLISHMENT OF VESSEL REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec....

  14. 46 CFR Sec. 3 - Specifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 8 2012-10-01 2012-10-01 false Specifications. Sec. 3 Section 3 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY PROCEDURE FOR ACCOMPLISHMENT OF VESSEL REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec....

  15. 76 FR 7482 - Operations Specifications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-10

    ... in common carriage (75 FR 25127). Specifically, the FAA proposed to clarify and standardize the rules... Printing Office's Web page at http://www.gpoaccess.gov/fr/index.html . You can also get a copy by sending a... attendants not identified by gender--140 pounds. (ii) Oil--350 pounds or the oil capacity as specified on...

  16. EDUCATIONAL SPECIFICATIONS FOR SECONDARY SCHOOLS.

    ERIC Educational Resources Information Center

    FLANIGAN, VIRGINIA; AND OTHERS

    THE REPORT CAN BE USED AS A GUIDE IN THE PREPARATION OF EDUCATIONAL SPECIFICATIONS FOR SECONDARY SCHOOLS. NEW CURRICULA, METHODS OF INSTRUCTION, AND TEACHING AIDS ADD TO THE SOPHISTICATION OF EDUCATION. PROGRAMS ENCOMPASS MANY AREAS OF EDUCATION, EACH REQUIRING PROFESSIONAL DECISIONS. THESE DECISIONS MUST BE ORGANIZED INTO WRITTEN SPECIFICATIONS…

  17. Portable File Format (PFF) specifications.

    SciTech Connect

    Dolan, Daniel H.,

    2015-02-01

    Created at Sandia National Laboratories, the Portable File Format (PFF) allows binary data transfer across computer platforms. Although this capability is supported by many other formats, PFF files are still in use at Sandia, particularly in pulsed power research. This report provides detailed PFF specifications for accessing data without relying on legacy code.

  18. Netware-Specific Network Security.

    ERIC Educational Resources Information Center

    Snyder, Robin M.

    This paper focuses on practical and cost-effective NetWare-specific approaches to information systems and computer security. A series of real world experiences is presented that illustrate fundamental information systems and security concepts. A NetWare network is a client-server network which uses a file server to share files while client…

  19. Specificity and Variability of Practice.

    ERIC Educational Resources Information Center

    Shea, Charles H.; Kohl, Robert M.

    1990-01-01

    Describes two experiments which examined how supplementing specific practice experiences with variable practice experiences influenced motor skill retention. Participants received varying trials of acquisition practice on a criterion force production task. Acquisition practice with variations of the criterion task led to better retention than…

  20. Specificity of Cardiovascular Endurance Training.

    ERIC Educational Resources Information Center

    Riley, Calberth B., Jr.; Johnson, James H.

    This study determined the specificity of cardiovascular endurance training on a bicycle ergometer. Eighteen male subjects were tested on a heart rate response test of 150 beats per minute on a bicycle ergometer at the pace of 50 revolutions per minute (rpm) and at 160 beats per minute at 60 and 80 rpm, with the resistance equal to the force of…

  1. [MHC tetramers: tracking specific immunity].

    PubMed

    Kosor, Ela; Gagro, Alenka; Drazenović, Vladimir; Kuzman, Ilija; Jeren, Tatjana; Rakusić, Snjezana; Rabatić, Sabina; Markotić, Alemka; Gotovac, Katja; Sabioncello, Ante; Cecuk, Esma; Kerhin-Brkljacić, Vesna; Gjenero-Margan, Ira; Kaić, Bernard; Mlinarić-Galinović, Gordana; Kastelan, Andrija; Dekaris, Dragan

    2003-01-01

    In an adaptive immune response, antigen is recognized by two distinct sets of highly variable receptor molecules: (1) immunoglobulins, that serve as antigen receptors on B cells and (2) the antigen-specific receptors on T cells. T cells play important role in the control of infection and in the development of protective immunity. These cells can also mediate anti-tumor effects and, in case of autoimmune syndromes, contribute to the development and pathology of disease. The specificity of T cells is determined by T cell receptors (TCR). Understanding of the success of immune responses requires the direct measurement of antigen-specific T lymphocytes. Cell with major histocompatibility complex (MHC) class I molecules are able to present antigens to antigen-specific CD8+ cytotoxic T lymphocytes. MHC class I molecules present small peptides (epitopes) processed from intracellular antigens such as viruses and intracellular bacteria. MHC class I molecules in humans are designated as human leukocyte antigen (HLA) class I and divided into HLA-A, -B and -C. CD8+ T cells recognize MHC class I molecules and after activation produce proteins that destroy infected cells. MHC class II molecules receive their peptides mainly from extracellular and soluble antigens and present them to the CD4+ T helper cells. A recently described technique that can be used in flow cytometry enables us to quantify ex vivo antigen-specific T cells by binding of soluble tetramer MHC-peptide complexes attached to fluorochrome. Quantitative analyses of antigen-specific T cell populations provide important information on the natural course of immune responses. The interaction of T cell receptors on T lymphocytes with tetrameric MHC-peptide complexes mimics the situation on the cell surface, and allows for reliable binding. Tetramers consist of four biotinylated HLA-peptide epitope complexes bound to streptavidin conjugated with fluorescent dye. Tetramer technology has sensitivity of detection as little

  2. Veteran-specific suicide prevention.

    PubMed

    York, Janet A; Lamis, Dorian A; Pope, Charlene A; Egede, Leonard E

    2013-06-01

    Suicide rates have been increasing in some subgroups of Veteran populations, such as those who have experienced combat. Several initiatives are addressing this critical need and the Department of Veterans Affairs (VA) has been recognized for its leadership. This integrative review adopts the Research Impact Framework (RIM) to address suicide-specific prevention activities targeting Veterans. The RIM is a standardized approach for developing issue narratives using four broad areas: societal-related impacts, research-related impacts, policy-related impacts, and service-related impacts. The questions addressed in this review are: (1) What are the major initiatives in Veteran-specific suicide prevention in four areas of impact-society, research, policy, and services? (2) Are there gaps related in each impact area? and (3) What are the implications of this narrative for other strategies to address suicide prevention targeting Veterans? Systematic application of the RIM identifies exemplars, milestones, gaps, and health disparity issues. PMID:23011459

  3. Isotope specific arbitrary material sorter

    SciTech Connect

    Barty, Christopher P.J.

    2015-12-08

    A laser-based mono-energetic gamma-ray source is used to provide a rapid and unique, isotope specific method for sorting materials. The objects to be sorted are passed on a conveyor in front of a MEGa-ray beam which has been tuned to the nuclear resonance fluorescence transition of the desired material. As the material containing the desired isotope traverses the beam, a reduction in the transmitted MEGa-ray beam occurs. Alternately, the laser-based mono-energetic gamma-ray source is used to provide non-destructive and non-intrusive, quantitative determination of the absolute amount of a specific isotope contained within pipe as part of a moving fluid or quasi-fluid material stream.

  4. Certifying Domain-Specific Policies

    NASA Technical Reports Server (NTRS)

    Lowry, Michael; Pressburger, Thomas; Rosu, Grigore; Koga, Dennis (Technical Monitor)

    2001-01-01

    Proof-checking code for compliance to safety policies potentially enables a product-oriented approach to certain aspects of software certification. To date, previous research has focused on generic, low-level programming-language properties such as memory type safety. In this paper we consider proof-checking higher-level domain -specific properties for compliance to safety policies. The paper first describes a framework related to abstract interpretation in which compliance to a class of certification policies can be efficiently calculated Membership equational logic is shown to provide a rich logic for carrying out such calculations, including partiality, for certification. The architecture for a domain-specific certifier is described, followed by an implemented case study. The case study considers consistency of abstract variable attributes in code that performs geometric calculations in Aerospace systems.

  5. Project X functional requirements specification

    SciTech Connect

    Holmes, S.D.; Henderson, S.D.; Kephart, R.; Kerby, J.; Mishra, S.; Nagaitsev, S.; Tschirhart, R.; /Fermilab

    2011-03-01

    Project X is a multi-megawatt proton facility being developed to support intensity frontier research in elementary particle physics, with possible applications to nuclear physics and nuclear energy research, at Fermilab. A Functional Requirements Specification has been developed in order to establish performance criteria for the Project X complex in support of these multiple missions. This paper will describe the Functional Requirements for the Project X facility and the rationale for these requirements.

  6. Pattern specificity of contrast adaptation

    PubMed Central

    Anstis, Stuart

    2014-01-01

    Contrast adaptation is specific to precisely localised edges, so that adapting to a flickering photograph makes one less sensitive to that same photograph, but not to similar photographs. When two low-contrast photos, A and B, are transparently superimposed, then adapting to a flickering high-contrast B leaves no net afterimage, but it makes B disappear from the A+B picture, which now simply looks like A. PMID:25165518

  7. Combinatorial Engineering of Dextransucrase Specificity

    PubMed Central

    Irague, Romain; Tarquis, Laurence; André, Isabelle; Moulis, Claire; Morel, Sandrine; Monsan, Pierre; Potocki-Véronèse, Gabrielle; Remaud-Siméon, Magali

    2013-01-01

    We used combinatorial engineering to investigate the relationships between structure and linkage specificity of the dextransucrase DSR-S from Leuconostoc mesenteroides NRRL B-512F, and to generate variants with altered specificity. Sequence and structural analysis of glycoside-hydrolase family 70 enzymes led to eight amino acids (D306, F353, N404, W440, D460, H463, T464 and S512) being targeted, randomized by saturation mutagenesis and simultaneously recombined. Screening of two libraries totaling 3.6.104 clones allowed the isolation of a toolbox comprising 81 variants which synthesize high molecular weight α-glucans with different proportions of α(1→3) linkages ranging from 3 to 20 %. Mutant sequence analysis, biochemical characterization and molecular modelling studies revealed the previously unknown role of peptide 460DYVHT464 in DSR-S linkage specificity. This peptide sequence together with residue S512 contribute to defining +2 subsite topology, which may be critical for the enzyme regiospecificity. PMID:24204991

  8. Specific test and evaluation plan

    SciTech Connect

    Hays, W.H.

    1997-12-09

    The purpose of this Specific Test and Evaluation Plan (STEP) is to provide a detailed written plan for the systematic testing of modifications made to the 241-AN-A Valve Pit by the W-314 Project. The STEP develops the outline for test procedures that verify the system`s performance to the established Project design criteria. The STEP is a ``lower tier`` document based on the W-314 Test and Evaluation Plan (TEP) This STEP encompasses all testing activities required to demonstrate compliance to the project design criteria as it relates to the modifications of the AN-A valve pit. The Project Design Specifications (PDS) identify the specific testing activities required for the Project. Testing includes Validations and Verifications (e.g., Commercial Grade Item Dedication activities), Factory Acceptance Tests (FATs), installation tests and inspections, Construction Acceptance Tests (CATs), Acceptance Test Procedures (ATPs), Pre-Operational Test Procedures (POTPs), and Operational Test Procedures (OTPs). It should be noted that POTPs are not required for testing of the modifications to the 241-AN-A Valve Pit. The STEP will be utilized in conjunction with the TEP for verification and validation.

  9. Chromosome specific repetitive DNA sequences

    DOEpatents

    Moyzis, Robert K.; Meyne, Julianne

    1991-01-01

    A method is provided for determining specific nucleotide sequences useful in forming a probe which can identify specific chromosomes, preferably through in situ hybridization within the cell itself. In one embodiment, chromosome preferential nucleotide sequences are first determined from a library of recombinant DNA clones having families of repetitive sequences. Library clones are identified with a low homology with a sequence of repetitive DNA families to which the first clones respectively belong and variant sequences are then identified by selecting clones having a pattern of hybridization with genomic DNA dissimilar to the hybridization pattern shown by the respective families. In another embodiment, variant sequences are selected from a sequence of a known repetitive DNA family. The selected variant sequence is classified as chromosome specific, chromosome preferential, or chromosome nonspecific. Sequences which are classified as chromosome preferential are further sequenced and regions are identified having a low homology with other regions of the chromosome preferential sequence or with known sequences of other family me This invention is the result of a contract with the Department of Energy (Contract No. W-7405-ENG-36).

  10. Observations of Debris Impact on Buildings and Infrastructure after the 2011 Tohoku Tsunami

    NASA Astrophysics Data System (ADS)

    Cox, D.; Naito, C.; Yu, K.; Mizutani, N.; Tsujio, D.

    2011-12-01

    We present observations of the performance of structural systems (buildings, bridges, port infrastructure) after the 2011 Tohoku Tsunami. In particular, our observations focused on the hydraulic, hydrodynamic and impact demands. While it is likely that hydraulic and hydrodynamic demands resulted in considerable destruction, debris impact events provided significant contribution to some of the losses observed. Current knowledge on how to quantify the effects of impact demands from tsunami generated debris is limited. Methods provided by code sources including ASCE 7, AASHTO LRFD, and the Coastal Construction Manual result in order of magnitude differences in expected demands. This RAPID investigation examined the demands generated by debris in different coastal communities including the Sendai plain (Natori, Sendai Port) and the ria coast (Onagawa, Rikuzentakata, Kesennuma, Minamisanriku). Our investigation quantifies debris type, damage type, and debris flow characteristics. Observations indicate that the Tohoku event generated a spectrum of debris ranging from wood, vehicles, and shipping containers, to entire houses and ships. The structural system types observed included reinforced concrete buildings, steel moment frame buildings, wood frame houses. Damages to fuel storage containers were also a focus of this investigation. In general, our observations show that debris loads can add significantly to the overall loads, particularly when the debris size is large relative to the impacted structure. In addition. the occurrence of impact events was not necessarily associated with all types of debris, and some structural systems were more sensitive to a type of impact demand. For example, open systems such as pile supported buildings which offered little flow resistance were more susceptible to debris strikes than bluff sided buildings. This material is based upon work supported by the National Science Foundation under Grant No. CMMI-1138668. Any opinions, findings

  11. HOW IMMUNE PEPTIDASES CHANGE SPECIFICITY

    PubMed Central

    Raymond, Wilfred W.; Trivedi, Neil N.; Makarova, Anastasia; Ray, Manisha; Craik, Charles S.; Caughey, George H.

    2014-01-01

    Cathepsin G is a major secreted serine peptidase of neutrophils and mast cells. Studies in Ctsg-null mice suggest that cathepsin G supports antimicrobial defenses but can injure host tissues. The human enzyme has unusual “Janus-faced” ability to cleave peptides at basic (tryptic) as well as aromatic (chymotryptic) sites. Tryptic activity has been attributed to acidic Glu226 in the primary specificity pocket and underlies proposed important functions such as activation of pro-urokinase. However, most mammals, including mice, substitute Ala for Glu226, suggesting that human tryptic activity may be anomalous. To test this hypothesis, human cathepsin G was compared with mouse wild type and humanized active site mutants, revealing that mouse primary specificity is markedly narrower than that of human cathepsin G, with much greater Tyr activity and selectivity and near absence of tryptic activity. It also differs from human in resisting tryptic peptidase inhibitors (e.g., aprotinin), while favoring angiotensin destruction at Tyr4 over activation at Phe8. Ala226Glu mutants of mouse cathepsin G acquire tryptic activity and human ability to activate pro-urokinase. Phylogenetic analysis reveals that the Ala226Glu missense mutation appearing in primates 31–43 million years ago represented an apparently unprecedented way to create tryptic activity in a serine peptidase. We propose that tryptic activity is not an attribute of ancestral mammalian cathepsin G, which was primarily chymotryptic, and that primate-selective broadening of specificity opposed the general trend of increased specialization by immune peptidases and allowed acquisition of new functions. PMID:20889553

  12. Project X functional requirements specification

    SciTech Connect

    Holmes, S.D.; Henderson, S.D.; Kephart, R.; Kerby, J.; Kourbanis, I.; Lebedev, V.; Mishra, S.; Nagaitsev, S.; Solyak, N.; Tschirhart, R.; /Fermilab

    2012-05-01

    Project X is a multi-megawatt proton facility being developed to support a world-leading program in Intensity Frontier physics at Fermilab. The facility is designed to support programs in elementary particle and nuclear physics, with possible applications to nuclear energy research. A Functional Requirements Specification has been developed in order to establish performance criteria for the Project X complex in support of these multiple missions, and to assure that the facility is designed with sufficient upgrade capability to provide U.S. leadership for many decades to come. This paper will briefly review the previously described Functional Requirements, and then discuss their recent evolution.

  13. [Genotypic specificity of schizophrenic psychoses].

    PubMed

    Shakhmatova-Pavlova, I V; Gindilis, V M; Rokhlina, M L; Kozlova, I A

    1980-01-01

    A total of 610 probands with a disease manifestation in childhood, middle and old age and their families were examined by the clinico-genealogical method. The results allowed conclusions that (1) there is an undoubted genetic relationship between schizophrenia of childhood, middle and old age; and that (2) among the closest relatives in families of the probands there is no significant (in comparison to the general population) accumulation of non-schizophrenic pathology. The latter indicates a high genotypic specificity of schizophrenia. PMID:7415694

  14. Logic programming and metadata specifications

    NASA Technical Reports Server (NTRS)

    Lopez, Antonio M., Jr.; Saacks, Marguerite E.

    1992-01-01

    Artificial intelligence (AI) ideas and techniques are critical to the development of intelligent information systems that will be used to collect, manipulate, and retrieve the vast amounts of space data produced by 'Missions to Planet Earth.' Natural language processing, inference, and expert systems are at the core of this space application of AI. This paper presents logic programming as an AI tool that can support inference (the ability to draw conclusions from a set of complicated and interrelated facts). It reports on the use of logic programming in the study of metadata specifications for a small problem domain of airborne sensors, and the dataset characteristics and pointers that are needed for data access.

  15. On task and theory specificity.

    PubMed

    Newell, K M

    1989-03-01

    One of the significant limitations of the motor control and skill acquisition domain is that the theories, models, and hypotheses are, in most cases, task specific. Many lines of theorizing fail to hold up under even small changes in task constraints, although clearly the field does have some robust phenomena. It is proposed that a broader consideration of the role of task constraints, which is grounded in the methodology of nonlinear dynamics, may help to formulate a more general action theory of coordination and control. PMID:15117675

  16. Central Solenoid Insert Technical Specification

    SciTech Connect

    Martovetsky, Nicolai N; Smirnov, Alexandre

    2011-09-01

    The US ITER Project Office (USIPO) is responsible for the ITER central solenoid (CS) contribution to the ITER project. The Central Solenoid Insert (CSI) project will allow ITER validation the appropriate lengths of the conductors to be used in the full-scale CS coils under relevant conditions. The ITER Program plans to build and test a CSI to verify the performance of the CS conductor. The CSI is a one-layer solenoid with an inner diameter of 1.48 m and a height of 4.45 m between electric terminal ends. The coil weight with the terminals is approximately 820 kg without insulation. The major goal of the CSI is to measure the temperature margin of the CS under the ITER direct current (DC) operating conditions, including determining sensitivity to load cycles. Performance of the joints, ramp rate sensitivity, and stability against thermal or electromagnetic disturbances, electrical insulation, losses, and instrumentation are addressed separately and therefore are not major goals in this project. However, losses and joint performance will be tested during the CSI testing campaign. The USIPO will build the CSI that will be tested at the Central Solenoid Model Coil (CSMC) Test Facility at the Japan Atomic Energy Agency (JAEA), Naka, Japan. The industrial vendors (the Suppliers) will report to the USIPO (the Company). All approvals to proceed will be issued by the Company, which in some cases, as specified in this document, will also require the approval of the ITER Organization. Responsibilities and obligations will be covered by respective contracts between the USIPO, called Company interchangeably, and the industrial Prime Contractors, called Suppliers. Different stages of work may be performed by more than one Prime Contractor, as described in this specification. Technical requirements of the contract between the Company and the Prime Contractor will be covered by the Fabrication Specifications developed by the Prime Contractor based on this document and approved by

  17. Hanford Site Environmental Management Specification

    SciTech Connect

    DAILY, J.L.

    2001-05-25

    The US Department of Energy, Richland Operations Office (RL) has established a document hierarchy as part of its integrated management system. The Strategic Plan defines the vision, values, missions, strategic goals, high-level outcomes, and the basic strategies in achieving those outcomes. As shown in Figure 1-1, the Site Specification derives requirements from the Strategic Plan and documents the top-level mission technical requirements for the work involved in the RL Hanford Site cleanup and infrastructure activities under the responsibility of the U.S. Department of Energy, Office of Environmental Management (EM). It also provides the basis for all contract technical requirements. Since this is limited to the EM work, neither the Fast Flux Test Facility (FFTF) nor the Pacific Northwest National Laboratory (PNNL) non-EM science activities are included. Figure 1-1 also shows the relationship between this Site Specification and the other Site management and planning documents. Similarly, the documents, orders, and laws referenced in this document represent only the most salient sources of requirements. Current and contractual reference data contain a complete set of source documents.

  18. Collective specification of cellular development.

    PubMed

    Sachs, Tsvi

    2003-09-01

    Studies of chimeras and in vivo development demonstrate that cell lineages are often quite variable, apparently in response to chance perturbations. This points to an apparent contradiction: although individual cells are the units of genetic information and differentiation, not all cellular events need be precise for the development of functional organisms. The social organization of ants can serve as a metaphor that helps understand the mechanisms that underlie such development. Ants suggest that continued cellular interactions and environmental conditions could specify the proportion and general location of specialized units. Leaf venation is used as a concrete example of this general principle. A signal produced continuously by all cells specifies a requirement for vein differentiation. The cells that respond by differentiation then transport the signal away from the leaf; this removal acting as a feedback indicating that the requirement is being met. Because transport increases during vein differentiation, early initiation occurs in excess and vein 'competition' for the signal assures an acceptable outcome. Such specification would be robust since it does not depend on events in any single cell, and chance events, rather than being corrected or reversed, may be built upon in reaching an expected, collective phenotype. The absence of detailed information preceding development distinguishes this hypothesis from the common alternatives of a program or blueprint. Collective specification would have important implications for developmental plasticity and evolution. PMID:12938179

  19. Flight Guidance System Requirements Specification

    NASA Technical Reports Server (NTRS)

    Miller, Steven P.; Tribble, Alan C.; Carlson, Timothy M.; Danielson, Eric J.

    2003-01-01

    This report describes a requirements specification written in the RSML-e language for the mode logic of a Flight Guidance System of a typical regional jet aircraft. This model was created as one of the first steps in a five-year project sponsored by the NASA Langley Research Center, Rockwell Collins Inc., and the Critical Systems Research Group of the University of Minnesota to develop new methods and tools to improve the safety of avionics designs. This model will be used to demonstrate the application of a variety of methods and techniques, including safety analysis of system and subsystem requirements, verification of key properties using theorem provers and model checkers, identification of potential sources mode confusion in system designs, partitioning of applications based on the criticality of system hazards, and autogeneration of avionics quality code. While this model is representative of the mode logic of a typical regional jet aircraft, it does not describe an actual or planned product. Several aspects of a full Flight Guidance System, such as recovery from failed sensors, have been omitted, and no claims are made regarding the accuracy or completeness of this specification.

  20. Arithmetic Memory Is Modality Specific

    PubMed Central

    Myers, Timothy; Szücs, Dénes

    2015-01-01

    In regards to numerical cognition and working memory, it is an open question as to whether numbers are stored into and retrieved from a central abstract representation or from separate notation-specific representations. This study seeks to help answer this by utilizing the numeral modality effect (NME) in three experiments to explore how numbers are processed by the human brain. The participants were presented with numbers (1–9) as either Arabic digits or written number words (Arabic digits and dot matrices in Experiment 2) at the first (S1) and second (S2) stimuli. The participant’s task was to add the first two stimuli together and verify whether the answer (S3), presented simultaneously with S2, was correct. We hypothesized that if reaction time (RT) at S2/S3 depends on the modality of S1 then numbers are retrieved from modality specific memory stores. Indeed, RT depended on the modality of S1 whenever S2 was an Arabic digit which argues against the concept of numbers being stored and retrieved from a central, abstract representation. PMID:26716692

  1. Specific Language Impairment Across Languages.

    PubMed

    Leonard, Laurence B

    2014-03-01

    Children with specific language impairment (SLI) have a significant and longstanding deficit in spoken language ability that adversely affects their social and academic well-being. Studies of children with SLI in a wide variety of languages reveal diverse symptoms, most of which seem to reflect weaknesses in grammatical computation and phonological short-term memory. The symptoms of the disorder are sensitive to the type of language being acquired, with extraordinary weaknesses seen in those areas of language that are relatively challenging for younger typically developing children. Although these children's deficits warrant clinical and educational attention, their weaknesses might reflect the extreme end of a language aptitude continuum rather than a distinct, separable condition. PMID:24765105

  2. Genetic specificity of face recognition

    PubMed Central

    Shakeshaft, Nicholas G.; Plomin, Robert

    2015-01-01

    Specific cognitive abilities in diverse domains are typically found to be highly heritable and substantially correlated with general cognitive ability (g), both phenotypically and genetically. Recent twin studies have found the ability to memorize and recognize faces to be an exception, being similarly heritable but phenotypically substantially uncorrelated both with g and with general object recognition. However, the genetic relationships between face recognition and other abilities (the extent to which they share a common genetic etiology) cannot be determined from phenotypic associations. In this, to our knowledge, first study of the genetic associations between face recognition and other domains, 2,000 18- and 19-year-old United Kingdom twins completed tests assessing their face recognition, object recognition, and general cognitive abilities. Results confirmed the substantial heritability of face recognition (61%), and multivariate genetic analyses found that most of this genetic influence is unique and not shared with other cognitive abilities. PMID:26417086

  3. DETERMINATION OF SPECIFIC NEUTRONIC REACTIVITY

    DOEpatents

    Dessauer, G.

    1960-05-10

    A method is given for production-line determination of the specific neutronic reactivity of such objects as individual nuclear fuel or neutron absorber elements and is notable for rapidity and apparatus simplicity. The object is incorporated in a slightly sub-critical chain fission reactive assembly having a discrete neutron source, thereby establishing a K/sub eff/ within the crucial range of 0.95 to 0.995. The range was found to afford, uniquely, flux- transient damped response in a niatter of seconds simultaneously with acceptable analytical sensitivity. The resulting neutron flux measured at a situs spaced from both object and source within the assembly serves as a calibrable indication of said reactivity.

  4. Specific test and evaluation plan

    SciTech Connect

    Hays, W.H.

    1998-03-20

    The purpose of this Specific Test and Evaluation Plan (STEP) is to provide a detailed written plan for the systematic testing of modifications made to the 241-AX-B Valve Pit by the W-314 Project. The STEP develops the outline for test procedures that verify the system`s performance to the established Project design criteria. The STEP is a lower tier document based on the W-314 Test and Evaluation Plan (TEP). Testing includes Validations and Verifications (e.g., Commercial Grade Item Dedication activities), Factory Acceptance Tests (FATs), installation tests and inspections, Construction Acceptance Tests (CATs), Acceptance Test Procedures (ATPs), Pre-Operational Test Procedures (POTPs), and Operational Test Procedures (OTPs). It should be noted that POTPs are not required for testing of the transfer line addition. The STEP will be utilized in conjunction with the TEP for verification and validation.

  5. Molecular-specific urokinase antibodies

    NASA Technical Reports Server (NTRS)

    Atassi, M. Zouhair (Inventor); Morrison, Dennis R. (Inventor)

    2009-01-01

    Antibodies have been developed against the different molecular forms of urokinase using synthetic peptides as immunogens. The peptides were synthesized specifically to represent those regions of the urokinase molecules which are exposed in the three-dimensional configuration of the molecule and are uniquely homologous to urokinase. Antibodies are directed against the lysine 158-isoleucine 159 peptide bond which is cleaved during activation from the single-chain (ScuPA) form to the bioactive double chain (54 KDa and 33 KDa) forms of urokinase and against the lysine 135 lysine 136 bond that is cleaved in the process of removing the alpha-chain from the 54 KDa form to produce the 33 KDa form of urokinase. These antibodies enable the direct measurement of the different molecular forms of urokinase from small samples of conditioned medium harvested from cell cultures.

  6. Formal specification of human-computer interfaces

    NASA Technical Reports Server (NTRS)

    Auernheimer, Brent

    1990-01-01

    A high-level formal specification of a human computer interface is described. Previous work is reviewed and the ASLAN specification language is described. Top-level specifications written in ASLAN for a library and a multiwindow interface are discussed.

  7. Specific Carbohydrate Diet: Does It Work?

    MedlinePlus

    ... Specific Carbohydrate Diet (SCD) Go Back The Specific Carbohydrate Diet (SCD) Email Print + Share There is no ... diet that has received attention is the Specific Carbohydrate Diet. This diet limits poorly digestible carbohydrates to ...

  8. High specific activity silicon-32

    DOEpatents

    Phillips, D.R.; Brzezinski, M.A.

    1996-06-11

    A process for preparation of silicon-32 is provided and includes contacting an irradiated potassium chloride target, including spallation products from a prior irradiation, with sufficient water, hydrochloric acid or potassium hydroxide to form a solution, filtering the solution, adjusting pH of the solution from about 5.5 to about 7.5, admixing sufficient molybdate-reagent to the solution to adjust the pH of the solution to about 1.5 and to form a silicon-molybdate complex, contacting the solution including the silicon-molybdate complex with a dextran-based material, washing the dextran-based material to remove residual contaminants such as sodium-22, separating the silicon-molybdate complex from the dextran-based material as another solution, adding sufficient hydrochloric acid and hydrogen peroxide to the solution to prevent reformation of the silicon-molybdate complex and to yield an oxidation state of the molybdate adapted for subsequent separation by an anion exchange material, contacting the solution with an anion exchange material whereby the molybdate is retained by the anion exchange material and the silicon remains in solution, and optionally adding sufficient alkali metal hydroxide to adjust the pH of the solution to about 12 to 13. Additionally, a high specific activity silicon-32 product having a high purity is provided.

  9. High specific activity silicon-32

    DOEpatents

    Phillips, Dennis R.; Brzezinski, Mark A.

    1996-01-01

    A process for preparation of silicon-32 is provided and includes contacting an irradiated potassium chloride target, including spallation products from a prior irradiation, with sufficient water, hydrochloric acid or potassium hydroxide to form a solution, filtering the solution, adjusting pH of the solution to from about 5.5 to about 7.5, admixing sufficient molybdate-reagent to the solution to adjust the pH of the solution to about 1.5 and to form a silicon-molybdate complex, contacting the solution including the silicon-molybdate complex with a dextran-based material, washing the dextran-based material to remove residual contaminants such as sodium-22, separating the silicon-molybdate complex from the dextran-based material as another solution, adding sufficient hydrochloric acid and hydrogen peroxide to the solution to prevent reformation of the silicon-molybdate complex and to yield an oxidization state of the molybdate adapted for subsequent separation by an anion exchange material, contacting the solution with an anion exchange material whereby the molybdate is retained by the anion exchange material and the silicon remains in solution, and optionally adding sufficient alkali metal hydroxide to adjust the pH of the solution to about 12 to 13. Additionally, a high specific activity silicon-32 product having a high purity is provided.

  10. Specific ventilation distribution in microgravity.

    PubMed

    Verbanck, S; Linnarsson, D; Prisk, G K; Paiva, M

    1996-05-01

    We studied the contribution of inter- and intraregional inhomogeneities of specific ventilation (delta V/Vo) from the rebreathing inert gas trace in microgravity and on Earth. The rebreathing tests were carried out by four astronauts before, during, and after the 10-day Spacelab D-2 mission. Starting from functional residual capacity, the rebreathing maneuver consisted of eight reinspirations from a bag filled with 1.8-2.2 liters of test gas mixtures containing approximately 5% argon. The rate of argon equilibration in the rebreathing bag, termed RBeq, was quantified by determining the logarithm of the actual minus the equilibrated argon concentrations normalized to the inspired minus the equilibrated argon concentrations. A compartmental model of the lung (S. Verbanck and M. Paiva. J. Appl. Physiol. 76: 445-454, 1994) was used to validate the method for determining RBeq and to simulate the influence of intra- and interregional delta V/Vo inhomogeneities on the RBeq curve. The comparison between the experimental Earth-based and microgravity RBeq curves and model simulations shows that gravity-independent delta V/Vo inhomogeneity is at least as large as gravity-dependent delta V/Vo inhomogeneity. PMID:8727527

  11. Specific Immunotherapy in Atopic Dermatitis

    PubMed Central

    Lee, Jungsoo; Park, Chang Ook

    2015-01-01

    Allergen specific immunotherapy (SIT) using house dust mite (HDM) extracts has been performed mainly with patients of asthma and allergic rhinitis. In the meanwhile, there has been a long debate on the efficacy of SIT in atopic dermatitis (AD) with only a few double-blind placebo-controlled trials. However, several randomized controlled trials of SIT in AD revealed significant improvement of clinical symptoms and also, positive result was shown by a following meta-analysis study of these trials. In order to predict and evaluate the treatment outcome, finding a biomarker that can predict treatment responses and treatment end-points is critical but it is very challenging at the same time due to the complexity of causes and mechanisms of AD. Other considerations including standardization of the easiest and safest treatment protocol and optimizing the treatment preparations should be studied as well. This review summarizes the basics of SIT in AD including the brief mechanisms, treatment methods and schedules, and also highlights the clinical efficacy of SIT in AD along with mild, controllable adverse reactions. Immunologic effects and studies of various biomarkers are also introduced and finally, future considerations with upcoming studies on SIT were discussed. PMID:25749758

  12. Are specific emotions narrated differently?

    PubMed

    Habermas, Tilmann; Meier, Michaela; Mukhtar, Barbara

    2009-12-01

    Two studies test the assertion that anger, sadness, fear, pride, and happiness are typically narrated in different ways. Everyday events eliciting these 5 emotions were narrated by young women (Study 1) and 5- and 8-year-old girls (Study 2). Negative narratives were expected to engender more effort to process the event, be longer, more grammatically complex, more often have a complication section, and use more specific emotion labels than global evaluations. Narratives of Hogan's (2003) juncture emotions anger and fear were expected to focus more on action and to contain more core narrative sections of orientation, complication, and resolution than narratives of the outcome emotions sadness and happiness. Hypotheses were confirmed for adults except for syntactic complexity, whereas children showed only some of these differences. Hogan's theory that juncture emotions are restricted to the complication section was not confirmed. Finally, in adults, indirect speech was more frequent in anger narratives and internal monologue in fear narratives. It is concluded that different emotions should be studied in how they are narrated, and that narratives should be analyzed according to qualitatively different emotions. PMID:20001120

  13. 12 CFR 324.207 - Specific risk.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 5 2014-01-01 2014-01-01 false Specific risk. 324.207 Section 324.207 Banks... ADEQUACY OF FDIC-SUPERVISED INSTITUTIONS Risk-Weighted Assets-Market Risk § 324.207 Specific risk. (a... the specific risk for each of its debt, equity, and securitization positions with specific risk....

  14. Model Commissioning Plan and Guide Specifications

    SciTech Connect

    1997-03-01

    The objectives of Model Commissioning Plan and Guide Specifications are to ensure that the design team applies commissioning concepts to the design and prepares commissioning specifications and a commission plan for inclusion in the bid construction documents.

  15. 21 CFR 660.5 - Specificity.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Antibody to Hepatitis B Surface Antigen § 660.5 Specificity. Each filling of the product shall be specific for antibody to hepatitis B surface antigen,...

  16. 21 CFR 660.44 - Specificity.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Hepatitis B Surface Antigen § 660.44 Specificity. Each filling of the product shall be specific for Hepatitis B Surface Antigen as determined...

  17. 21 CFR 660.5 - Specificity.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Antibody to Hepatitis B Surface Antigen § 660.5 Specificity. Each filling of the product shall be specific for antibody to hepatitis B surface antigen,...

  18. 21 CFR 660.44 - Specificity.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Hepatitis B Surface Antigen § 660.44 Specificity. Each filling of the product shall be specific for Hepatitis B Surface Antigen as determined...

  19. Low temperature specific heat of propylene glycol

    SciTech Connect

    Zhu, Da-Ming; Chen, Huiwei

    1997-01-01

    The specific heat of propylene glycol has been measured at temperatures from 0.1 K to 6 K. The magnitude and the temperature dependence of the specific heat are similar to that found in other fragile glasses.

  20. Goddard trajectory determination subsystem: Mathematical specifications

    NASA Technical Reports Server (NTRS)

    Wagner, W. E. (Editor); Velez, C. E. (Editor)

    1972-01-01

    The mathematical specifications of the Goddard trajectory determination subsystem of the flight dynamics system are presented. These specifications include the mathematical description of the coordinate systems, dynamic and measurement model, numerical integration techniques, and statistical estimation concepts.

  1. 21 CFR 660.5 - Specificity.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Antibody to Hepatitis B Surface Antigen § 660.5 Specificity. Each filling of the product shall be specific for antibody to hepatitis B surface antigen,...

  2. 21 CFR 660.44 - Specificity.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Hepatitis B Surface Antigen § 660.44 Specificity. Each filling of the product shall be specific for Hepatitis B Surface Antigen as determined...

  3. 21 CFR 660.5 - Specificity.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Antibody to Hepatitis B Surface Antigen § 660.5 Specificity. Each filling of the product shall be specific for antibody to hepatitis B surface antigen,...

  4. 21 CFR 660.44 - Specificity.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Hepatitis B Surface Antigen § 660.44 Specificity. Each filling of the product shall be specific for Hepatitis B Surface Antigen as determined...

  5. 21 CFR 660.5 - Specificity.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Antibody to Hepatitis B Surface Antigen § 660.5 Specificity. Each filling of the product shall be specific for antibody to hepatitis B surface antigen,...

  6. 21 CFR 660.44 - Specificity.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Hepatitis B Surface Antigen § 660.44 Specificity. Each filling of the product shall be specific for Hepatitis B Surface Antigen as determined...

  7. Domain and Specification Models for Software Engineering

    NASA Technical Reports Server (NTRS)

    Iscoe, Neil; Liu, Zheng-Yang; Feng, Guohui

    1992-01-01

    This paper discusses our approach to representing application domain knowledge for specific software engineering tasks. Application domain knowledge is embodied in a domain model. Domain models are used to assist in the creation of specification models. Although many different specification models can be created from any particular domain model, each specification model is consistent and correct with respect to the domain model. One aspect of the system-hierarchical organization is described in detail.

  8. Development of specifications for caramel colours.

    PubMed

    Licht, B H; Shaw, K; Smith, C; Mendoza, M; Orr, J; Myers, D V

    1992-05-01

    Specifications have been developed to define each of the four classes of caramel colour. The specifications were based on analysis of a large database generated during the course of characterization studies of each of the classes. A series of simple and practical tests was developed for the analysis of caramel colour samples to ensure conformity to the specifications. PMID:1644379

  9. 14 CFR 34.81 - Fuel specifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Fuel specifications. 34.81 Section 34.81 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT FUEL VENTING AND... Emissions (Aircraft Gas Turbine Engines) § 34.81 Fuel specifications. Fuel having specifications as...

  10. 40 CFR 87.81 - Fuel specifications.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 20 2011-07-01 2011-07-01 false Fuel specifications. 87.81 Section 87.81 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... (Aircraft Gas Turbine Engines) § 87.81 Fuel specifications. Fuel having specifications as provided in §...

  11. 14 CFR 34.81 - Fuel specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Fuel specifications. 34.81 Section 34.81 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT FUEL VENTING AND... Emissions (Aircraft Gas Turbine Engines) § 34.81 Fuel specifications. Fuel having specifications as...

  12. 40 CFR 87.81 - Fuel specifications.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 21 2012-07-01 2012-07-01 false Fuel specifications. 87.81 Section 87...) Definitions. Test Procedures for Engine Smoke Emissions (Aircraft Gas Turbine Engines) § 87.81 Fuel specifications. Fuel having specifications as provided in § 87.61 shall be used in smoke emission testing....

  13. 40 CFR 86.1413 - Fuel specifications.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 20 2012-07-01 2012-07-01 false Fuel specifications. 86.1413 Section... Trucks; Certification Short Test Procedures § 86.1413 Fuel specifications. (a) The test fuel to be used... octane specification of the fuels does not apply. For all gasoline-fueled Otto-cycle light-duty...

  14. 40 CFR 86.213 - Fuel specifications.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... testing under this subpart must meet the specifications for low-temperature test fuel in 40 CFR 1065.703. ... 40 Protection of Environment 19 2014-07-01 2014-07-01 false Fuel specifications. 86.213 Section 86... Passenger Vehicles; Cold Temperature Test Procedures § 86.213 Fuel specifications. (a) Gasoline. Use...

  15. 40 CFR 86.1413 - Fuel specifications.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 20 2013-07-01 2013-07-01 false Fuel specifications. 86.1413 Section... Trucks; Certification Short Test Procedures § 86.1413 Fuel specifications. (a) The test fuel to be used... octane specification of the fuels does not apply. For all gasoline-fueled Otto-cycle light-duty...

  16. 40 CFR 87.81 - Fuel specifications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Fuel specifications. 87.81 Section 87.81 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... (Aircraft Gas Turbine Engines) § 87.81 Fuel specifications. Fuel having specifications as provided in §...

  17. 14 CFR 34.81 - Fuel specifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Fuel specifications. 34.81 Section 34.81 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT FUEL VENTING AND... Emissions (Aircraft Gas Turbine Engines) § 34.81 Fuel specifications. Fuel having specifications as...

  18. 40 CFR 86.1413 - Fuel specifications.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 19 2011-07-01 2011-07-01 false Fuel specifications. 86.1413 Section... Trucks; Certification Short Test Procedures § 86.1413 Fuel specifications. (a) The test fuel to be used... octane specification of the fuels does not apply. For all gasoline-fueled Otto-cycle light-duty...

  19. 40 CFR 86.1413 - Fuel specifications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 19 2010-07-01 2010-07-01 false Fuel specifications. 86.1413 Section... Trucks; Certification Short Test Procedures § 86.1413 Fuel specifications. (a) The test fuel to be used... octane specification of the fuels does not apply. For all gasoline-fueled Otto-cycle light-duty...

  20. K-ABC Subtest Specificity Recalculated.

    ERIC Educational Resources Information Center

    Bracken, Bruce A.; Howell, Karen Kuehn

    1989-01-01

    Provides recalculated subtest specificity figures for Kaufman Assessment Battery for Children (K-ABC) and corrects original calculation errors made during determination of subtests specificity when instrument was first published. Recalculated figures indicate that K-ABC has more specific variance than was originally thought. Questions about…

  1. Specific cooling capacity of liquid nitrogen

    NASA Technical Reports Server (NTRS)

    Kilgore, R. A.; Adcock, J. B.

    1977-01-01

    The assumed cooling process and the method used to calculate the specific cooling capacity of liquid nitrogen are described, and the simple equation fitted to the calculated specific cooling capacity data, together with the graphical form calculated values of the specific cooling capacity of nitrogen for stagnation temperatures from saturation to 350 K and stagnation pressures from 1 to 10 atmospheres, are given.

  2. Methods for chromosome-specific staining

    DOEpatents

    Gray, Joe W.; Pinkel, Daniel

    1995-01-01

    Methods and compositions for chromosome-specific staining are provided. Compositions comprise heterogenous mixtures of labeled nucleic acid fragments having substantially complementary base sequences to unique sequence regions of the chromosomal DNA for which their associated staining reagent is specific. Methods include methods for making the chromosome-specific staining compositions of the invention, and methods for applying the staining compositions to chromosomes.

  3. Information Concerning Preparation of Specifications for Carpeting.

    ERIC Educational Resources Information Center

    Gilliland, John W.

    This paper argues for detailed, written carpeting specifications to assure that schools obtain quality products at competitive prices. The advantages of and specifications for school carpeting are given. A sample written specification contains items on: scope, general features, materials, acoustic characteristics, identification and acoustic…

  4. 12 CFR 217.207 - Specific risk.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 2 2014-01-01 2014-01-01 false Specific risk. 217.207 Section 217.207 Banks... OF BOARD-REGULATED INSTITUTIONS Risk-Weighted Assets-Market Risk § 217.207 Specific risk. (a) General... risk for each of its debt, equity, and securitization positions with specific risk. (b)...

  5. Requirements Specification Language (RSL) and supporting tools

    NASA Technical Reports Server (NTRS)

    Frincke, Deborah; Wolber, Dave; Fisher, Gene; Cohen, Gerald C.

    1992-01-01

    This document describes a general purpose Requirement Specification Language (RSL). RSL is a hybrid of features found in several popular requirement specification languages. The purpose of RSL is to describe precisely the external structure of a system comprised of hardware, software, and human processing elements. To overcome the deficiencies of informal specification languages, RSL includes facilities for mathematical specification. Two RSL interface tools are described. The Browser view contains a complete document with all details of the objects and operations. The Dataflow view is a specialized, operation-centered depiction of a specification that shows how specified operations relate in terms of inputs and outputs.

  6. Methods for chromosome-specific staining

    DOEpatents

    Gray, J.W.; Pinkel, D.

    1995-09-05

    Methods and compositions for chromosome-specific staining are provided. Compositions comprise heterogeneous mixtures of labeled nucleic acid fragments having substantially complementary base sequences to unique sequence regions of the chromosomal DNA for which their associated staining reagent is specific. Methods include ways for making the chromosome-specific staining compositions of the invention, and methods for applying the staining compositions to chromosomes. 3 figs.

  7. 77 FR 15399 - Model Safety Evaluation for Plant-Specific Adoption of Technical Specifications Task Force...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-15

    ... (76 FR 73737), is available under ADAMS Accession No. ML120200484. NRC's PDR: You may examine and... COMMISSION Model Safety Evaluation for Plant-Specific Adoption of Technical Specifications Task Force...-specific adoption of Technical Specifications (TS) Task Force (TSTF) Traveler TSTF-505, Revision...

  8. 43 CFR 3861.2 - Surveys: Specific.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Surveys: Specific. 3861.2 Section 3861.2..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL PATENT APPLICATIONS Surveys and Plats § 3861.2 Surveys: Specific....

  9. 43 CFR 3861.2 - Surveys: Specific.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Surveys: Specific. 3861.2 Section 3861.2..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL PATENT APPLICATIONS Surveys and Plats § 3861.2 Surveys: Specific....

  10. 43 CFR 3861.2 - Surveys: Specific.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Surveys: Specific. 3861.2 Section 3861.2..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL PATENT APPLICATIONS Surveys and Plats § 3861.2 Surveys: Specific....

  11. 43 CFR 3861.2 - Surveys: Specific.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Surveys: Specific. 3861.2 Section 3861.2..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL PATENT APPLICATIONS Surveys and Plats § 3861.2 Surveys: Specific....

  12. 32 CFR 292.4 - Specific policy.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false Specific policy. 292.4 Section 292.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM OF INFORMATION ACT PROGRAM DEFENSE INTELLIGENCE AGENCY (DIA) FREEDOM OF INFORMATION ACT § 292.4 Specific policy. (a) Definition of a Record. The...

  13. 50 CFR 648.165 - Framework specifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Framework specifications. 648.165 Section... Atlantic Bluefish Fishery § 648.165 Framework specifications. Link to an amendment published at 76 FR 60641... through its annual review or framework adjustment process that minimum fish sizes are necessary to...

  14. Identifying Specific Comprehension Deficits in Children

    ERIC Educational Resources Information Center

    Gifford, Diane Baty

    2013-01-01

    Research has shown that educators may be missing an under-identified population of approximately 10 percent of typically developing children, who have fluent, age-appropriate decoding and word recognition skills, yet have specific difficulties with other higher-level text processing factors. These children are said to have specific comprehension…

  15. 50 CFR 660.508 - Annual specifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Annual specifications. 660.508 Section 660.508 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES OFF WEST COAST STATES Coastal Pelagics Fisheries § 660.508 Annual specifications. (a)...

  16. 40 CFR 92.113 - Fuel specifications.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 21 2013-07-01 2013-07-01 false Fuel specifications. 92.113 Section 92...) CONTROL OF AIR POLLUTION FROM LOCOMOTIVES AND LOCOMOTIVE ENGINES Test Procedures § 92.113 Fuel specifications. (a) Diesel test fuel. (1) The diesel fuels for testing locomotives or locomotive engines...

  17. 40 CFR 92.113 - Fuel specifications.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 20 2014-07-01 2013-07-01 true Fuel specifications. 92.113 Section 92...) CONTROL OF AIR POLLUTION FROM LOCOMOTIVES AND LOCOMOTIVE ENGINES Test Procedures § 92.113 Fuel specifications. (a) Diesel test fuel. (1) The diesel fuels for testing locomotives or locomotive engines...

  18. 40 CFR 86.1513 - Fuel specifications.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... § 86.1513 Fuel specifications. The requirements of this section are set forth in 40 CFR part 1065... 40 Protection of Environment 20 2013-07-01 2013-07-01 false Fuel specifications. 86.1513 Section 86.1513 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS...

  19. 40 CFR 92.113 - Fuel specifications.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 20 2011-07-01 2011-07-01 false Fuel specifications. 92.113 Section 92...) CONTROL OF AIR POLLUTION FROM LOCOMOTIVES AND LOCOMOTIVE ENGINES Test Procedures § 92.113 Fuel specifications. (a) Diesel test fuel. (1) The diesel fuels for testing locomotives or locomotive engines...

  20. 40 CFR 86.1513 - Fuel specifications.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., and Liquefied Petroleum Gas-Fueled Diesel-Cycle Light-Duty Trucks; Idle Test Procedures § 86.1513 Fuel specifications. The requirements of this section are set forth in 40 CFR part 1065, subpart H, for heavy-duty... 40 Protection of Environment 19 2014-07-01 2014-07-01 false Fuel specifications. 86.1513...

  1. 40 CFR 86.1513 - Fuel specifications.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... § 86.1513 Fuel specifications. The requirements of this section are set forth in 40 CFR part 1065... 40 Protection of Environment 20 2012-07-01 2012-07-01 false Fuel specifications. 86.1513 Section 86.1513 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS...

  2. 40 CFR 92.113 - Fuel specifications.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 21 2012-07-01 2012-07-01 false Fuel specifications. 92.113 Section 92...) CONTROL OF AIR POLLUTION FROM LOCOMOTIVES AND LOCOMOTIVE ENGINES Test Procedures § 92.113 Fuel specifications. (a) Diesel test fuel. (1) The diesel fuels for testing locomotives or locomotive engines...

  3. 40 CFR 86.1513 - Fuel specifications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... § 86.1513 Fuel specifications. The requirements of this section are set forth in 40 CFR part 1065... 40 Protection of Environment 19 2010-07-01 2010-07-01 false Fuel specifications. 86.1513 Section 86.1513 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS...

  4. 40 CFR 92.113 - Fuel specifications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Fuel specifications. 92.113 Section 92...) CONTROL OF AIR POLLUTION FROM LOCOMOTIVES AND LOCOMOTIVE ENGINES Test Procedures § 92.113 Fuel specifications. (a) Diesel test fuel. (1) The diesel fuels for testing locomotives or locomotive engines...

  5. 40 CFR 86.1513 - Fuel specifications.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... § 86.1513 Fuel specifications. The requirements of this section are set forth in 40 CFR part 1065... 40 Protection of Environment 19 2011-07-01 2011-07-01 false Fuel specifications. 86.1513 Section 86.1513 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS...

  6. 16 CFR 1210.15 - Specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Specifications. 1210.15 Section 1210.15 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR CIGARETTE LIGHTERS Certification Requirements § 1210.15 Specifications. (a)...

  7. 16 CFR 1210.15 - Specifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Specifications. 1210.15 Section 1210.15 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR CIGARETTE LIGHTERS Certification Requirements § 1210.15 Specifications. (a)...

  8. 16 CFR 1210.15 - Specifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Specifications. 1210.15 Section 1210.15 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR CIGARETTE LIGHTERS Certification Requirements § 1210.15 Specifications. (a)...

  9. 32 CFR 292.4 - Specific policy.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Specific policy. 292.4 Section 292.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM OF INFORMATION ACT PROGRAM DEFENSE INTELLIGENCE AGENCY (DIA) FREEDOM OF INFORMATION ACT § 292.4 Specific...

  10. 10 CFR 1016.6 - Specific waivers.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Specific waivers. 1016.6 Section 1016.6 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) SAFEGUARDING OF RESTRICTED DATA General Provisions § 1016.6 Specific waivers. DOE may, upon application of any interested party, grant such waivers from the requirements...

  11. 16 CFR 1212.15 - Specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Specifications. 1212.15 Section 1212.15 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR MULTI-PURPOSE LIGHTERS Certification Requirements § 1212.15 Specifications. (a)...

  12. General specifications covering requirements of aeronautic instruments

    NASA Technical Reports Server (NTRS)

    1917-01-01

    Report includes specifications for the use and production of instruments used in the navigation and operation of aircraft. Specifications are included for the following instruments: barometer or altimeter, compass, air speed meter, inclinometer, drift meter, tachometer, oil gauge, oil pressure gauge, gasoline gauge, gasoline flow indicator, distance indicator, barograph, angle of attack indicator, radiator temperature indicator, gasoline feed system pressure indicator, sextant, airplane director.

  13. 44 CFR 6.87 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Specific exemptions. 6.87 Section 6.87 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF... Specific exemptions. (a) Exempt under 5 U.S.C. 552a(k)(1). The Administrator, Federal Emergency...

  14. 32 CFR 1801.63 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 6 2012-07-01 2012-07-01 false Specific exemptions. 1801.63 Section 1801.63 National Defense Other Regulations Relating to National Defense NATIONAL COUNTERINTELLIGENCE CENTER PUBLIC RIGHTS UNDER THE PRIVACY ACT OF 1974 Exemptions § 1801.63 Specific exemptions. Pursuant to...

  15. 32 CFR 1801.63 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Specific exemptions. 1801.63 Section 1801.63 National Defense Other Regulations Relating to National Defense NATIONAL COUNTERINTELLIGENCE CENTER PUBLIC RIGHTS UNDER THE PRIVACY ACT OF 1974 Exemptions § 1801.63 Specific exemptions. Pursuant to...

  16. 32 CFR 1801.63 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Specific exemptions. 1801.63 Section 1801.63 National Defense Other Regulations Relating to National Defense NATIONAL COUNTERINTELLIGENCE CENTER PUBLIC RIGHTS UNDER THE PRIVACY ACT OF 1974 Exemptions § 1801.63 Specific exemptions. Pursuant to...

  17. 32 CFR 1801.63 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 6 2014-07-01 2014-07-01 false Specific exemptions. 1801.63 Section 1801.63 National Defense Other Regulations Relating to National Defense NATIONAL COUNTERINTELLIGENCE CENTER PUBLIC RIGHTS UNDER THE PRIVACY ACT OF 1974 Exemptions § 1801.63 Specific exemptions. Pursuant to...

  18. Motorcycle Education Curriculum Specifications. Final Report.

    ERIC Educational Resources Information Center

    McKnight, A. James; And Others

    This report contains specifications for a motorcycle safety education curriculum designed to reduce the incidence and severity of motorcycle accidents. The specifications prescribe objectives, prerequisites, methods, materials, equipment, facilities, and proficiency measures for six units of instruction: (1) basic riding skills, (2) street riding…

  19. 14 CFR 91.1015 - Management specifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Management specifications. 91.1015 Section... Operations Program Management § 91.1015 Management specifications. (a) Each person conducting operations under this subpart or furnishing fractional ownership program management services to fractional...

  20. 14 CFR 91.1015 - Management specifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Management specifications. 91.1015 Section... Operations Program Management § 91.1015 Management specifications. (a) Each person conducting operations under this subpart or furnishing fractional ownership program management services to fractional...

  1. 14 CFR 91.1015 - Management specifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Management specifications. 91.1015 Section... Operations Program Management § 91.1015 Management specifications. (a) Each person conducting operations under this subpart or furnishing fractional ownership program management services to fractional...

  2. 14 CFR 91.1015 - Management specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Management specifications. 91.1015 Section... Operations Program Management § 91.1015 Management specifications. (a) Each person conducting operations under this subpart or furnishing fractional ownership program management services to fractional...

  3. 14 CFR 91.1015 - Management specifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Management specifications. 91.1015 Section... Operations Program Management § 91.1015 Management specifications. (a) Each person conducting operations under this subpart or furnishing fractional ownership program management services to fractional...

  4. 14 CFR 25.1397 - Color specifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Color specifications. 25.1397 Section 25... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Equipment Lights § 25.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  5. 14 CFR 29.1397 - Color specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Color specifications. 29.1397 Section 29... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Lights § 29.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  6. 14 CFR 23.1397 - Color specifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Color specifications. 23.1397 Section 23.1397 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... Color specifications. Each position light color must have the applicable International Commission...

  7. 14 CFR 23.1397 - Color specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Color specifications. 23.1397 Section 23.1397 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... Color specifications. Each position light color must have the applicable International Commission...

  8. 14 CFR 29.1397 - Color specifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Color specifications. 29.1397 Section 29... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Lights § 29.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  9. 14 CFR 25.1397 - Color specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Color specifications. 25.1397 Section 25... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Equipment Lights § 25.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  10. 14 CFR 27.1397 - Color specifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Color specifications. 27.1397 Section 27... AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Equipment Lights § 27.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  11. 14 CFR 27.1397 - Color specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Color specifications. 27.1397 Section 27... AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Equipment Lights § 27.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination...

  12. 14 CFR 29.1397 - Color specifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Lights § 29.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination chromaticity... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Color specifications. 29.1397 Section...

  13. 14 CFR 29.1397 - Color specifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Color specifications. 29.1397 Section 29.1397 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Lights § 29.1397 Color specifications. Each position light color must have the...

  14. 14 CFR 25.1397 - Color specifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Equipment Lights § 25.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination chromaticity... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Color specifications. 25.1397 Section...

  15. 14 CFR 23.1397 - Color specifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Color specifications. Each position light color must have the applicable International Commission on... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Color specifications. 23.1397 Section 23.1397 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION...

  16. 14 CFR 23.1397 - Color specifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Color specifications. Each position light color must have the applicable International Commission on... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Color specifications. 23.1397 Section 23.1397 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION...

  17. 14 CFR 23.1397 - Color specifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Color specifications. Each position light color must have the applicable International Commission on... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Color specifications. 23.1397 Section 23.1397 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION...

  18. 14 CFR 29.1397 - Color specifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Lights § 29.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination chromaticity... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Color specifications. 29.1397 Section...

  19. 14 CFR 27.1397 - Color specifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Color specifications. 27.1397 Section 27.1397 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Equipment Lights § 27.1397 Color specifications. Each position light color must have the...

  20. 14 CFR 27.1397 - Color specifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Equipment Lights § 27.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination chromaticity... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Color specifications. 27.1397 Section...

  1. 14 CFR 27.1397 - Color specifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Equipment Lights § 27.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination chromaticity... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Color specifications. 27.1397 Section...

  2. 14 CFR 25.1397 - Color specifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Equipment Lights § 25.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination chromaticity... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Color specifications. 25.1397 Section...

  3. 14 CFR 25.1397 - Color specifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Equipment Lights § 25.1397 Color specifications. Each position light color must have the applicable International Commission on Illumination chromaticity... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Color specifications. 25.1397 Section...

  4. 10 CFR 73.5 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Specific exemptions. 73.5 Section 73.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PHYSICAL PROTECTION OF PLANTS AND MATERIALS General Provisions § 73.5 Specific exemptions. The Commission may, upon application of any interested person or upon its...

  5. 10 CFR 73.5 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Specific exemptions. 73.5 Section 73.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PHYSICAL PROTECTION OF PLANTS AND MATERIALS General Provisions § 73.5 Specific exemptions. The Commission may, upon application of any interested person or upon its...

  6. 10 CFR 73.5 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Specific exemptions. 73.5 Section 73.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PHYSICAL PROTECTION OF PLANTS AND MATERIALS General Provisions § 73.5 Specific exemptions. The Commission may, upon application of any interested person or upon its...

  7. 10 CFR 73.5 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Specific exemptions. 73.5 Section 73.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PHYSICAL PROTECTION OF PLANTS AND MATERIALS General Provisions § 73.5 Specific exemptions. The Commission may, upon application of any interested person or upon its own initiative, grant such exemptions from...

  8. 10 CFR 73.5 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Specific exemptions. 73.5 Section 73.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PHYSICAL PROTECTION OF PLANTS AND MATERIALS General Provisions § 73.5 Specific exemptions. The Commission may, upon application of any interested person or upon its...

  9. 12 CFR 347.119 - Specific consent.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 5 2012-01-01 2012-01-01 false Specific consent. 347.119 Section 347.119 Banks... INTERNATIONAL BANKING § 347.119 Specific consent. General consent and expedited processing under this subpart do... activity that can be engaged in by foreign branches, which are not authorized under §§ 347.117 or...

  10. 12 CFR 347.119 - Specific consent.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Specific consent. 347.119 Section 347.119 Banks... INTERNATIONAL BANKING § 347.119 Specific consent. General consent and expedited processing under this subpart do... activity that can be engaged in by foreign branches, which are not authorized under §§ 347.117 or...

  11. 12 CFR 347.119 - Specific consent.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Specific consent. 347.119 Section 347.119 Banks... INTERNATIONAL BANKING § 347.119 Specific consent. General consent and expedited processing under this subpart do... activity that can be engaged in by foreign branches, which are not authorized under §§ 347.117 or...

  12. 12 CFR 347.119 - Specific consent.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 5 2014-01-01 2014-01-01 false Specific consent. 347.119 Section 347.119 Banks... INTERNATIONAL BANKING § 347.119 Specific consent. General consent and expedited processing under this subpart do... activity that can be engaged in by foreign branches, which are not authorized under §§ 347.117 or...

  13. 12 CFR 347.119 - Specific consent.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 5 2013-01-01 2013-01-01 false Specific consent. 347.119 Section 347.119 Banks... INTERNATIONAL BANKING § 347.119 Specific consent. General consent and expedited processing under this subpart do... activity that can be engaged in by foreign branches, which are not authorized under §§ 347.117 or...

  14. 10 CFR 63.43 - License specification.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false License specification. 63.43 Section 63.43 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses License Issuance and Amendment § 63.43 License specification. (a) A...

  15. 10 CFR 63.43 - License specification.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false License specification. 63.43 Section 63.43 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses License Issuance and Amendment § 63.43 License specification. (a) A...

  16. 10 CFR 63.43 - License specification.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false License specification. 63.43 Section 63.43 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses License Issuance and Amendment § 63.43 License specification. (a) A...

  17. 10 CFR 63.43 - License specification.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false License specification. 63.43 Section 63.43 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses License Issuance and Amendment § 63.43 License specification. (a) A...

  18. 10 CFR 63.43 - License specification.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false License specification. 63.43 Section 63.43 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses License Issuance and Amendment § 63.43 License specification. (a) A...

  19. 32 CFR 292.4 - Specific policy.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false Specific policy. 292.4 Section 292.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM OF INFORMATION ACT PROGRAM DEFENSE INTELLIGENCE AGENCY (DIA) FREEDOM OF INFORMATION ACT § 292.4 Specific...

  20. 32 CFR 292.4 - Specific policy.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Specific policy. 292.4 Section 292.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM OF INFORMATION ACT PROGRAM DEFENSE INTELLIGENCE AGENCY (DIA) FREEDOM OF INFORMATION ACT § 292.4 Specific...

  1. Stress and Specificity: Reply to Miller (2009)

    ERIC Educational Resources Information Center

    Denson, Thomas F.; Spanovic, Marija; Miller, Norman

    2009-01-01

    T. F. Denson, M. Spanovic, and N. Miller (2009) meta-analytically tested the hypotheses that specific appraisals and emotions would predict cortisol and immune responses to laboratory stressors and emotion inductions. Although the cortisol data supported the integrated specificity hypothesis, G. E. Miller (2009) raised questions concerning the…

  2. Specificity of a Maximal Step Exercise Test

    ERIC Educational Resources Information Center

    Darby, Lynn A.; Marsh, Jennifer L.; Shewokis, Patricia A.; Pohlman, Roberta L.

    2007-01-01

    To adhere to the principle of "exercise specificity" exercise testing should be completed using the same physical activity that is performed during exercise training. The present study was designed to assess whether aerobic step exercisers have a greater maximal oxygen consumption (max VO sub 2) when tested using an activity specific, maximal step…

  3. 44 CFR 6.87 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true Specific exemptions. 6.87 Section 6.87 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL IMPLEMENTATION OF THE PRIVACY ACT OF 1974 Exempt Systems of Records § 6.87 Specific exemptions. (a) Exempt under 5 U.S.C....

  4. 48 CFR 408.712 - Specification changes.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Specification changes. 408.712 Section 408.712 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE COMPETITION AND... People Who Are Blind or Severely Disabled 408.712 Specification changes. Prior to providing...

  5. 48 CFR 408.712 - Specification changes.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Specification changes. 408.712 Section 408.712 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE COMPETITION AND... People Who Are Blind or Severely Disabled 408.712 Specification changes. Prior to providing...

  6. 48 CFR 408.712 - Specification changes.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Specification changes. 408.712 Section 408.712 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE COMPETITION AND... People Who Are Blind or Severely Disabled 408.712 Specification changes. Prior to providing...

  7. 48 CFR 408.712 - Specification changes.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Specification changes. 408.712 Section 408.712 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE COMPETITION AND... People Who Are Blind or Severely Disabled 408.712 Specification changes. Prior to providing...

  8. 48 CFR 8.712 - Specification changes.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Specification changes. 8... Are Blind or Severely Disabled 8.712 Specification changes. (a) The contracting activity shall notify the AbilityOne participating nonprofit agency and appropriate central nonprofit agency of any...

  9. 48 CFR 408.712 - Specification changes.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Specification changes. 408.712 Section 408.712 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE COMPETITION AND... People Who Are Blind or Severely Disabled 408.712 Specification changes. Prior to providing...

  10. Plutonium Immobilization Can Loading Preliminary Specifications

    SciTech Connect

    Kriikku, E.

    1998-11-25

    This report discusses the Plutonium Immobilization can loading preliminary equipment specifications and includes a process block diagram, process description, equipment list, preliminary equipment specifications, plan and elevation sketches, and some commercial catalogs. This report identifies loading pucks into cans and backfilling cans with helium as the top priority can loading development areas.

  11. 28 CFR 0.131 - Specific functions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Specific functions. 0.131 Section 0.131 Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE Bureau of Alcohol, Tobacco, Firearms, and Explosives § 0.131 Specific functions. The Director of the Bureau of Alcohol, Tobacco, Firearms, and Explosives shall:...

  12. 46 CFR 171.130 - Specific applicability.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Specific applicability. 171.130 Section 171.130 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO VESSELS CARRYING PASSENGERS Drainage of Weather Decks § 171.130 Specific applicability....

  13. 46 CFR 171.130 - Specific applicability.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Specific applicability. 171.130 Section 171.130 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO VESSELS CARRYING PASSENGERS Drainage of Weather Decks § 171.130 Specific applicability....

  14. 46 CFR 171.130 - Specific applicability.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Specific applicability. 171.130 Section 171.130 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO VESSELS CARRYING PASSENGERS Drainage of Weather Decks § 171.130 Specific applicability....

  15. 28 CFR 0.131 - Specific functions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Specific functions. 0.131 Section 0.131 Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE Bureau of Alcohol, Tobacco, Firearms, and Explosives § 0.131 Specific functions. The Director of the Bureau of Alcohol, Tobacco, Firearms, and Explosives shall:...

  16. 28 CFR 0.131 - Specific functions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Specific functions. 0.131 Section 0.131 Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE Bureau of Alcohol, Tobacco, Firearms, and Explosives § 0.131 Specific functions. The Director of the Bureau of Alcohol, Tobacco, Firearms, and Explosives shall:...

  17. 10 CFR 26.9 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Specific exemptions. 26.9 Section 26.9 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.9 Specific exemptions. Upon application of any interested person or on its own initiative, the Commission may grant such exemptions...

  18. 10 CFR 26.9 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Specific exemptions. 26.9 Section 26.9 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.9 Specific exemptions. Upon application of any interested person or on its own initiative, the Commission may grant such exemptions...

  19. 10 CFR 26.9 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Specific exemptions. 26.9 Section 26.9 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.9 Specific exemptions. Upon application of any interested person or on its own initiative, the Commission may grant such exemptions...

  20. 10 CFR 26.9 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Specific exemptions. 26.9 Section 26.9 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.9 Specific exemptions. Upon application of any interested person or on its own initiative, the Commission may grant such exemptions...

  1. 10 CFR 26.9 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Specific exemptions. 26.9 Section 26.9 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.9 Specific exemptions. Upon application of any interested person or on its own initiative, the Commission may grant such exemptions...

  2. 324 and 327 Facilities Environmental Effluent Specifications

    SciTech Connect

    JOHNSON, D.L.

    1999-08-30

    These effluent specifications address requirements for the 324/321 Facilities, which are undergoing stabilization activities. Effluent specifications are imposed to protect personnel, the environment and the public, by ensuring adequate implementation and compliance with federal and state regulatory requirements and Hanford programs.

  3. 49 CFR 451.23 - Plate specifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 6 2013-10-01 2013-10-01 false Plate specifications. 451.23 Section 451.23... SECURITY SAFETY APPROVAL OF CARGO CONTAINERS TESTING AND APPROVAL OF CONTAINERS Safety Approval Plate § 451.23 Plate specifications. (a) The safety approval plate must be of the size and in the...

  4. 49 CFR 451.23 - Plate specifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false Plate specifications. 451.23 Section 451.23... SECURITY SAFETY APPROVAL OF CARGO CONTAINERS TESTING AND APPROVAL OF CONTAINERS Safety Approval Plate § 451.23 Plate specifications. (a) The safety approval plate must be of the size and in the...

  5. 49 CFR 451.23 - Plate specifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 6 2014-10-01 2014-10-01 false Plate specifications. 451.23 Section 451.23... SECURITY SAFETY APPROVAL OF CARGO CONTAINERS TESTING AND APPROVAL OF CONTAINERS Safety Approval Plate § 451.23 Plate specifications. (a) The safety approval plate must be of the size and in the...

  6. 49 CFR 451.23 - Plate specifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 6 2012-10-01 2012-10-01 false Plate specifications. 451.23 Section 451.23... SECURITY SAFETY APPROVAL OF CARGO CONTAINERS TESTING AND APPROVAL OF CONTAINERS Safety Approval Plate § 451.23 Plate specifications. (a) The safety approval plate must be of the size and in the...

  7. 5 CFR 2100.13 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 3 2011-01-01 2011-01-01 false Specific exemptions. 2100.13 Section 2100... PROCEDURES § 2100.13 Specific exemptions. Subsection (k) of 5 U.S.C. 552a authorizes the AFRH to adopt rules designating eligible system of records as exempt from certain requirements of 5 U.S.C. 552a. To be...

  8. 46 CFR 170.160 - Specific applicability

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Specific applicability 170.160 Section 170.160 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY STABILITY REQUIREMENTS FOR ALL INSPECTED VESSELS Weather Criteria § 170.160 Specific applicability (a) Except as...

  9. 46 CFR 171.130 - Specific applicability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Specific applicability. 171.130 Section 171.130 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO VESSELS CARRYING PASSENGERS Drainage of Weather Decks § 171.130 Specific applicability....

  10. 46 CFR 171.130 - Specific applicability.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Specific applicability. 171.130 Section 171.130 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO VESSELS CARRYING PASSENGERS Drainage of Weather Decks § 171.130 Specific applicability....

  11. 10 CFR 55.11 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Specific exemptions. 55.11 Section 55.11 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES Exemptions § 55.11 Specific exemptions. The Commission... endanger life or property and are otherwise in the public interest....

  12. 10 CFR 55.11 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Specific exemptions. 55.11 Section 55.11 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES Exemptions § 55.11 Specific exemptions. The Commission... endanger life or property and are otherwise in the public interest....

  13. 10 CFR 55.11 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Specific exemptions. 55.11 Section 55.11 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES Exemptions § 55.11 Specific exemptions. The Commission... endanger life or property and are otherwise in the public interest....

  14. 10 CFR 55.11 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Specific exemptions. 55.11 Section 55.11 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES Exemptions § 55.11 Specific exemptions. The Commission may, upon application by an interested person, or upon its own initiative, grant such exemptions from the requirements of the regulations...

  15. 10 CFR 52.7 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Specific exemptions. 52.7 Section 52.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General Provisions § 52.7 Specific exemptions. The Commission may, upon application by any interested person or...

  16. 21 CFR 1230.21 - Specific guaranty.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... FEDERAL CAUSTIC POISON ACT Guaranty § 1230.21 Specific guaranty. If a guaranty in respect to any specific... Caustic Poison Act. (Signature and address of guarantor) (b) Substances for other than household use (this... be misbranded within the meaning of the Federal Caustic Poison Act. (Name and address of...

  17. 21 CFR 1230.21 - Specific guaranty.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... FEDERAL CAUSTIC POISON ACT Guaranty § 1230.21 Specific guaranty. If a guaranty in respect to any specific... Caustic Poison Act. (Signature and address of guarantor) (b) Substances for other than household use (this... be misbranded within the meaning of the Federal Caustic Poison Act. (Name and address of...

  18. 21 CFR 1230.21 - Specific guaranty.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... FEDERAL CAUSTIC POISON ACT Guaranty § 1230.21 Specific guaranty. If a guaranty in respect to any specific... Caustic Poison Act. (Signature and address of guarantor) (b) Substances for other than household use (this... be misbranded within the meaning of the Federal Caustic Poison Act. (Name and address of...

  19. 21 CFR 1230.21 - Specific guaranty.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... FEDERAL CAUSTIC POISON ACT Guaranty § 1230.21 Specific guaranty. If a guaranty in respect to any specific... Caustic Poison Act. (Signature and address of guarantor) (b) Substances for other than household use (this... be misbranded within the meaning of the Federal Caustic Poison Act. (Name and address of...

  20. 21 CFR 1230.21 - Specific guaranty.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... FEDERAL CAUSTIC POISON ACT Guaranty § 1230.21 Specific guaranty. If a guaranty in respect to any specific... Caustic Poison Act. (Signature and address of guarantor) (b) Substances for other than household use (this... be misbranded within the meaning of the Federal Caustic Poison Act. (Name and address of...

  1. 10 CFR 76.23 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Specific exemptions. 76.23 Section 76.23 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS General Provisions § 76.23 Specific exemptions. The Commission may, upon its own initiative or upon application of the...

  2. 10 CFR 76.23 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Specific exemptions. 76.23 Section 76.23 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS General Provisions § 76.23 Specific exemptions. The Commission may, upon its own initiative or upon application of the...

  3. 10 CFR 76.23 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Specific exemptions. 76.23 Section 76.23 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS General Provisions § 76.23 Specific exemptions. The Commission may, upon its own initiative or upon application of the...

  4. 10 CFR 76.23 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Specific exemptions. 76.23 Section 76.23 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS General Provisions § 76.23 Specific exemptions. The Commission may, upon its own initiative or upon application of the...

  5. 10 CFR 76.23 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Specific exemptions. 76.23 Section 76.23 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS General Provisions § 76.23 Specific exemptions. The Commission may, upon its own initiative or upon application of the...

  6. 10 CFR 52.7 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Specific exemptions. 52.7 Section 52.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General Provisions § 52.7 Specific exemptions. The Commission may, upon application by any interested person or...

  7. 10 CFR 52.7 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Specific exemptions. 52.7 Section 52.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General Provisions § 52.7 Specific exemptions. The Commission may, upon application by any interested person or...

  8. 10 CFR 52.7 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Specific exemptions. 52.7 Section 52.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General Provisions § 52.7 Specific exemptions. The Commission may, upon application by any interested person or...

  9. 10 CFR 52.7 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Specific exemptions. 52.7 Section 52.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General Provisions § 52.7 Specific exemptions. The Commission may, upon application by any interested person or...

  10. Cell-Type-Specific Optogenetics in Monkeys.

    PubMed

    Namboodiri, Vijay Mohan K; Stuber, Garret D

    2016-09-01

    The recent advent of technologies enabling cell-type-specific recording and manipulation of neuronal activity spurred tremendous progress in neuroscience. However, they have been largely limited to mice, which lack the richness in behavior of primates. Stauffer et al. now present a generalizable method for achieving cell-type specificity in monkeys. PMID:27610562

  11. 49 CFR 451.23 - Plate specifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 6 2011-10-01 2011-10-01 false Plate specifications. 451.23 Section 451.23 Transportation Other Regulations Relating to Transportation (Continued) COAST GUARD, DEPARTMENT OF HOMELAND SECURITY SAFETY APPROVAL OF CARGO CONTAINERS TESTING AND APPROVAL OF CONTAINERS Safety Approval Plate § 451.23 Plate specifications. (a) The...

  12. 46 CFR 170.174 - Specific applicability.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Specific applicability. 170.174 Section 170.174 Shipping... REQUIREMENTS FOR ALL INSPECTED VESSELS Determination of Lightweight Displacement and Centers of Gravity § 170.174 Specific applicability. This subpart applies to each vessel for which the lightweight...

  13. 46 CFR 170.174 - Specific applicability.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Specific applicability. 170.174 Section 170.174 Shipping... REQUIREMENTS FOR ALL INSPECTED VESSELS Determination of Lightweight Displacement and Centers of Gravity § 170.174 Specific applicability. This subpart applies to each vessel for which the lightweight...

  14. 46 CFR 170.174 - Specific applicability.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Specific applicability. 170.174 Section 170.174 Shipping... REQUIREMENTS FOR ALL INSPECTED VESSELS Determination of Lightweight Displacement and Centers of Gravity § 170.174 Specific applicability. This subpart applies to each vessel for which the lightweight...

  15. 46 CFR 170.174 - Specific applicability.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Specific applicability. 170.174 Section 170.174 Shipping... REQUIREMENTS FOR ALL INSPECTED VESSELS Determination of Lightweight Displacement and Centers of Gravity § 170.174 Specific applicability. This subpart applies to each vessel for which the lightweight...

  16. 7 CFR 1.123 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false Specific exemptions. 1.123 Section 1.123 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Privacy Act Regulations § 1.123 Specific exemptions. Pursuant to 5 U.S.C. 552a(k), the systems of records (or portions thereof)...

  17. 46 CFR 174.010 - Specific applicability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Specific applicability. 174.010 Section 174.010 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO SPECIFIC VESSEL TYPES Special Rules Pertaining to Deck Cargo Barges § 174.010...

  18. 16 CFR 1702.11 - Product specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Product specifications. 1702.11 Section 1702.11 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970... AND REQUIREMENTS § 1702.11 Product specifications. Each petition for an exemption shall include: (a)...

  19. 12 CFR 3.207 - Specific risk.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Specific risk. 3.207 Section 3.207 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY CAPITAL ADEQUACY STANDARDS Risk-Weighted Assets-Market Risk § 3.207 Specific risk. (a) General requirement. A national bank or Federal...

  20. Task-specific dystonia: pathophysiology and management.

    PubMed

    Sadnicka, Anna; Kassavetis, Panagiotis; Pareés, Isabel; Meppelink, Anne Marthe; Butler, Katherine; Edwards, Mark

    2016-09-01

    Task-specific dystonia is a form of isolated focal dystonia with the peculiarity of being displayed only during performance of a specific skilled motor task. This distinctive feature makes task-specific dystonia a particularly mysterious and fascinating neurological condition. In this review, we cover phenomenology and its increasingly broad-spectrum risk factors for the disease, critically review pathophysiological theories and evaluate current therapeutic options. We conclude by highlighting the unique features of task-specific dystonia within the wider concept of dystonia. We emphasise the central contribution of environmental risk factors, and propose a model by which these triggers may impact on the motor control of skilled movement. By viewing task-specific dystonia through this new lens which considers the disorder a modifiable disorder of motor control, we are optimistic that research will yield novel therapeutic avenues for this highly motivated group of patients. PMID:26818730

  1. Improvements to Technical Specifications surveillance requirements

    SciTech Connect

    Lobel, R.; Tjader, T.R.

    1992-12-01

    In August 1983 an NRC task group was formed to investigate problems with surveillance testing required by Technical Specifications, and to recommend approaches to effect improvements. NUREG-1024 ( Technical Specifications-Enhancing Safety Impact'') resulted, and it contained recommendations to review the basis for test frequencies; to ensure that the tests promote safety and do not degrade equipment; and to review surveillance tests so that they do not unnecessarily burden personnel. The Technical Specifications Improvement Program (TSIP) was established in December 1984 to provide the framework for rewriting and improving the Technical Specifications. As an element of the TSIP, all Technical Specifications surveillance requirements were comprehensively examined as recommended in NUREG-1024. The results of that effort are presented in this report. The study found that while some testing at power is essential to verify equipment and system operability, safety can be improved, equipment degradation decreased, and unnecessary personnel burden relaxed by reducing the amount of testing at power.

  2. On the Specificity of Adaptive Mutations

    PubMed Central

    Hall, B. G.

    1997-01-01

    Adaptive mutations are mutations that occur in nondividing or slowly dividing cells during prolonged nonlethal selection, and that appear to be specific to the challenge of the selection in the sense that the only mutations that arise are those that provide a growth advantage to the cell. The issue of the specificity has been controversial because it violates our most basic assumptions about the randomness of mutations with respect to their effect on the cell. Although a variety of experiments in several systems in both bacteria and yeast have claimed to demonstrate that specificity, those experiments have been subjected to a variety of technical criticisms suggesting that the specificity may not be real. Here I use the ebg system to provide evidence that when selection is applied to one specific nucleotide site within a gene, mutation occurs at that site but not at an alternative and equally mutable site within the same gene. PMID:9017388

  3. Tissue Specific Promoters in Colorectal Cancer

    PubMed Central

    Rama, A. R.; Aguilera, A.; Melguizo, C.; Caba, O.; Prados, J.

    2015-01-01

    Colorectal carcinoma is the third most prevalent cancer in the world. In the most advanced stages, the use of chemotherapy induces a poor response and is usually accompanied by other tissue damage. Significant progress based on suicide gene therapy has demonstrated that it may potentiate the classical cytotoxic effects in colorectal cancer. The inconvenience still rests with the targeting and the specificity efficiency. The main target of gene therapy is to achieve an effective vehicle to hand over therapeutic genes safely into specific cells. One possibility is the use of tumor-specific promoters overexpressed in cancers. They could induce a specific expression of therapeutic genes in a given tumor, increasing their localized activity. Several promoters have been assayed into direct suicide genes to cancer cells. This review discusses the current status of specific tumor-promoters and their great potential in colorectal carcinoma treatment. PMID:26648599

  4. Structured representation for requirements and specifications

    NASA Technical Reports Server (NTRS)

    Cohen, Gerald C.; Fisher, Gene; Frincke, Deborah; Wolber, Dave

    1991-01-01

    This document was generated in support of NASA contract NAS1-18586, Design and Validation of Digital Flight Control Systems suitable for Fly-By-Wire Applications, Task Assignment 2. Task 2 is associated with a formal representation of requirements and specifications. In particular, this document contains results associated with the development of a Wide-Spectrum Requirements Specification Language (WSRSL) that can be used to express system requirements and specifications in both stylized and formal forms. Included with this development are prototype tools to support the specification language. In addition a preliminary requirements specification methodology based on the WSRSL has been developed. Lastly, the methodology has been applied to an Advanced Subsonic Civil Transport Flight Control System.

  5. Breckinridge Project, initial effort. Report III, Volume 2. Specifications

    SciTech Connect

    1982-01-01

    Report III, Volume 2 contains those specifications numbered K through Y, as follows: Specifications for Compressors (K); Specifications for Piping (L); Specifications for Structures (M); Specifications for Insulation (N); Specifications for Electrical (P); Specifications for Concrete (Q); Specifications for Civil (S); Specifications for Welding (W); Specifications for Painting (X); and Specifications for Special (Y). The standard specifications of Bechtel Petroleum Incorporated have been amended as necessary to reflect the specific requirements of the Breckinridge Project and the more stringent specifications of Ashland Synthetic Fuels, Inc. These standard specifications are available for the Initial Effort (Phase Zero) work performed by all contractors and subcontractors.

  6. Constructing specifications by combining parallel elaborations

    SciTech Connect

    Feather, M.S.

    1989-02-01

    Constructing specifications of complex tasks is often a laborious activity in spite of the rich vocabulary provided by specification languages. An incremental approach to construction is proposed, with the virtue of offering considerable opportunity for mechanized support. Following this approach one builds a specification through a series of elaborations that incrementally adjust a simple initial specification. Elaborations perform both refinements, adding further detail, and adaptations, retracting oversimplifications and tailoring approximations to the specifics of the task. It is anticipated that the vast majority of elaborations can be concisely described to a mechanism which will then perform them automatically. When elaborations are independent, they can be applied in parallel, leading to diverging specifications which must later be recombined. The approach is intended to facilitate comprehension and maintenance of specifications, as well as their initial construction. The advantages of following this approach stem from the gradual nature of the elaboration process, the separation of concerns through following independent elaborations in parallel, the simplicity of the individual elaboration steps (the effects of each step are well delineated), and the availability of an explicit record of construction.

  7. Benchmark Generation using Domain Specific Modeling

    SciTech Connect

    Bui, Ngoc B.; Zhu, Liming; Gorton, Ian; Liu, Yan

    2007-08-01

    Performance benchmarks are domain specific applications that are specialized to a certain set of technologies and platforms. The development of a benchmark application requires mapping the performance specific domain concepts to an implementation and producing complex technology and platform specific code. Domain Specific Modeling (DSM) promises to bridge the gap between application domains and implementations by allowing designers to specify solutions in domain-specific abstractions and semantics through Domain Specific Languages (DSL). This allows generation of a final implementation automatically from high level models. The modeling and task automation benefits obtained from this approach usually justify the upfront cost involved. This paper employs a DSM based approach to invent a new DSL, DSLBench, for benchmark generation. DSLBench and its associated code generation facilities allow the design and generation of a completely deployable benchmark application for performance testing from a high level model. DSLBench is implemented using Microsoft Domain Specific Language toolkit. It is integrated with the Visual Studio 2005 Team Suite as a plug-in to provide extra modeling capabilities for performance testing. We illustrate the approach using a case study based on .Net and C#.

  8. The classic cadherins in synaptic specificity

    PubMed Central

    Basu, Raunak; Taylor, Matthew R; Williams, Megan E

    2015-01-01

    During brain development, billions of neurons organize into highly specific circuits. To form specific circuits, neurons must build the appropriate types of synapses with appropriate types of synaptic partners while avoiding incorrect partners in a dense cellular environment. Defining the cellular and molecular rules that govern specific circuit formation has significant scientific and clinical relevance because fine scale connectivity defects are thought to underlie many cognitive and psychiatric disorders. Organizing specific neural circuits is an enormously complicated developmental process that requires the concerted action of many molecules, neural activity, and temporal events. This review focuses on one class of molecules postulated to play an important role in target selection and specific synapse formation: the classic cadherins. Cadherins have a well-established role in epithelial cell adhesion, and although it has long been appreciated that most cadherins are expressed in the brain, their role in synaptic specificity is just beginning to be unraveled. Here, we review past and present studies implicating cadherins as active participants in the formation, function, and dysfunction of specific neural circuits and pose some of the major remaining questions. PMID:25837840

  9. Mechanisms of allergen-specific immunotherapy.

    PubMed

    Akdis, Cezmi A; Akdis, Mübeccel

    2011-01-01

    Allergen-specific immunotherapy has been used for 100 years as a desensitizing therapy for allergic diseases and represents the potentially curative and specific method of treatment. The mechanisms of action of allergen-specific immunotherapy include the very early desensitization effects, modulation of T-and B-cell responses and related antibody isotypes, and migration of eosinophils, basophils, and mast cells to tissues, as well as release of their mediators. Regulatory T (Treg) cells have been identified as key regulators of immunologic processes in peripheral tolerance to allergens. Skewing of allergen-specific effector T cells to a regulatory phenotype appears as a key event in the development of healthy immune response to allergens and successful outcome in patients undergoing allergen-specific immunotherapy. Naturally occurring forkhead box protein 3-positive CD4(+)CD25(+) Treg cells and inducible T(R)1 cells contribute to the control of allergen-specific immune responses in several major ways, which can be summarized as suppression of dendritic cells that support the generation of effector T cells; suppression of effector T(H)1, T(H)2, and T(H)17 cells; suppression of allergen-specific IgE and induction of IgG4; suppression of mast cells, basophils, and eosinophils; and suppression of effector T-cell migration to tissues. New strategies for immune intervention will likely include targeting of the molecular mechanisms of allergen tolerance and reciprocal regulation of effector and Treg cell subsets. PMID:21211639

  10. Bias and design in software specifications

    NASA Technical Reports Server (NTRS)

    Straub, Pablo A.; Zelkowitz, Marvin V.

    1990-01-01

    Implementation bias in a specification is an arbitrary constraint in the solution space. Presented here is a model of bias in software specifications. Bias is defined in terms of the specification process and a classification of the attributes of the software product. Our definition of bias provides insight into both the origin and the consequences of bias. It also shows that bias is relative and essentially unavoidable. Finally, we describe current work on defining a measure of bias, formalizing our model, and relating bias to software defects.

  11. Cell specific, variable density, polymer microspheres

    NASA Technical Reports Server (NTRS)

    Yen, Shiao-Ping S. (Inventor); Rembaum, Alan (Inventor); Molday, Robert S. (Inventor)

    1977-01-01

    Biocompatible polymeric microspheres having an average diameter below about 3 microns and having density at least 15% greater or lesser than organic cells and having covalent binding sites are provided in accordance with this invention. The microspheres are obtained by copolymerizing a hydroxy or amine substituted acrylic monomer such as hydroxyethylmethacrylate with a light or dense comonomer such as a fluoromonomer. A lectin or antibody is bound to the hydroxy or amine site of the bead to provide cell specificity. When added to a cell suspension the marked bead will specifically label the cell membrane by binding to specific receptor sites thereon. The labelled membrane can then be separated by density gradient centrifugation.

  12. Age-specific migration and regional diversity.

    PubMed

    Morrill, R

    1994-11-01

    "This author examines patterns of age-specific migration between 1980 and 1990 for a small, growing region, the Pacific Northwest of the U.S.A., with the purpose of assessing the degree of geographic diversity in experience. A simple typology of the expected spatial and structural pattern of age-specific migration is proposed. Cluster analysis is used to group counties on the basis of age-specific rates of net migration. Even this fairly small region is found to exemplify most of the patterns that might be expected to occur in the nation as a whole." PMID:12288335

  13. Nonprocedural-dataflow specification of concurrent programs

    SciTech Connect

    Prywes, N.; Szymanski, B.; Shi, Y.

    1983-01-01

    A previously developed nonprocedural specification language model and its program generator are extended to concurrent programming. The specification of concurrent programs in model and the generation of the corresponding object programs is illustrated through a resource allocation example which consists of a number of parallel processes that request and release resources and a monitor process that allocates requested resources. The discussion is particularized by the example of the dining philosophers problem. To provide background, the author reviews the methodology of the program generator for (1) checking the global and local consistency and completeness of the specification, and (2) generating a schedule of program events to attain efficiency in program execution. 20 references.

  14. A novel monoclonal antibody specific for cocaine.

    PubMed

    Nakayama, Hiroshi; Kenjyou, Noriko; Shigetoh, Nobuyuki

    2013-08-01

    Detection systems for the illegal drug cocaine need to have a high sensitivity and specificity for cocaine and to be relatively easy to use. In the current study, a monoclonal antibody (MAb) with a high specificity for cocaine was produced. Enzyme-linked immunosorbent assay and fluorescence quenching immunoassay were used to screen the hybridomas. The MAb S27Y (IgG1) was shown to be sensitive and specific for cocaine and quenched fluorescence. Thus, S27Y has the potential to be used in screening assays for the rapid and sensitive detection of cocaine. PMID:23909419

  15. Gender-Specific Health Challenges Facing Women

    MedlinePlus

    ... Specific Health Challenges Facing Women Questions and Answers Science Advances Skip Website Tools Website Tools Print this page Get email updates Order publications Volunteer for Clinical Studies Help improve ...

  16. 50 CFR 648.294 - Framework specifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Tilefish Fishery § 648.294 Framework specifications. (a) Within-season management action. The Council may... for an entire harvest/fishing season. (ii) Whether there has been adequate notice and opportunity...

  17. Double Shell Tank (DST) Utilities Specification

    SciTech Connect

    SUSIENE, W.T.

    2000-04-27

    This specification establishes the performance requirements and provides the references to the requisite codes and standards to he applied during the design of the Double-Shell Tank (DST) Utilities Subsystems that support the first phase of waste feed delivery (WFD). The DST Utilities Subsystems provide electrical power, raw/potable water, and service/instrument air to the equipment and structures used to transfer low-activity waste (LAW) and high-level waste (HLW) to designated DST staging tanks. The DST Utilities Subsystems also support the equipment and structures used to deliver blended LAW and HLW feed from these staging tanks to the River Protection Project (RPP) Privatization Contractor facility where the waste will be immobilized. This specification is intended to be the basis for new projects/installations. This specification is not intended to retroactively affect previously established project design criteria without specific direction by the program.

  18. 50 CFR 648.260 - Specifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., DEPARTMENT OF COMMERCE FISHERIES OF THE NORTHEASTERN UNITED STATES Management Measures for the Atlantic Deep... Atlantic Deep-Sea Red Crab FMP objectives and other FMP provisions. (b) Development of specifications....

  19. Development of simulation computer complex specification

    NASA Technical Reports Server (NTRS)

    1973-01-01

    The Training Simulation Computer Complex Study was one of three studies contracted in support of preparations for procurement of a shuttle mission simulator for shuttle crew training. The subject study was concerned with definition of the software loads to be imposed on the computer complex to be associated with the shuttle mission simulator and the development of procurement specifications based on the resulting computer requirements. These procurement specifications cover the computer hardware and system software as well as the data conversion equipment required to interface the computer to the simulator hardware. The development of the necessary hardware and software specifications required the execution of a number of related tasks which included, (1) simulation software sizing, (2) computer requirements definition, (3) data conversion equipment requirements definition, (4) system software requirements definition, (5) a simulation management plan, (6) a background survey, and (7) preparation of the specifications.

  20. Scintimammography (Breast Specific Gamma Imaging-BSGI)

    MedlinePlus

    ... computer to help investigate an abnormality discovered on mammography. Its ability to detect cancer is not limited ... a breast abnormality that has been discovered on mammography. Scintimammography is also known as Breast Specific Gamma ...

  1. 48 CFR 836.202 - Specifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... specifications. (b) During the design stage, contract architect-engineers must not use “brand name or equal” or... phase, prior to award of a contract for design. (c) If VA has determined that only one product will...

  2. Cockpit management and Specific Behavioral Objectives (SBOs)

    NASA Technical Reports Server (NTRS)

    Mudge, R. W.

    1987-01-01

    One of the primary tools used to accomplish the task of effective training is the specific behavioral objective (SBO). An SBO is simply a statement which specifically identifies a small segment of the final behavior sought, and a little more. The key word is specific. The company pinpoints exactly what it is it wants the pilot to do after completing training, and what it should evaluate from the point of view of both the program and the pilot. It tells the junior crewmember exactly, specifically, what he should monitor and support insofar as the management function is concerned. It gives greater meaning to the term second in command. And finally, it tells the supervisory pilot exactly what he should observe, evaluate, and instruct, insofar as the management function is concerned.

  3. Surface cleanliness of fluid systems, specification for

    NASA Technical Reports Server (NTRS)

    1995-01-01

    This specification establishes surface cleanliness levels, test methods, cleaning and packaging requirements, and protection and inspection procedures for determining surface cleanliness. These surfaces pertain to aerospace parts, components, assemblies, subsystems, and systems in contact with any fluid medium.

  4. Technical requirements specification for tank waste retrieval

    SciTech Connect

    Lamberd, D.L.

    1996-09-26

    This document provides the technical requirements specification for the retrieval of waste from the underground storage tanks at the Hanford Site. All activities covered by this scope are conducted in support of the Tank Waste Remediation System (TWRS) mission.

  5. Developing Educational Specifications for Academic Chemistry Buildings.

    ERIC Educational Resources Information Center

    Chlad, Frank L.

    1985-01-01

    Provides information related to the design of chemistry classrooms and laboratories. Project cost estimates, space assignment by function, generation of space requirements, educational specifications, and space conversion formulas (considering net assignable square feet) are among the topics discussed. (JN)

  6. Mitochondria-specific Conjugated Polymer Nanoparticles

    PubMed Central

    Twomey, Megan; Mendez, Eladio; Manian, Rajesh Kumar

    2016-01-01

    Biodegradable conjugated polymer nanoparticles (CPNs) were prepared for high mitochondria targeting in live cancer cells. The degradable CPNs are nontoxic and specifically localized to mitochondria of live tumor cells through macropinocytosis followed by intracellular degradation and trafficking. PMID:26974193

  7. MAP kinase cascades: scaffolding signal specificity.

    PubMed

    van Drogen, Frank; Peter, Matthias

    2002-01-22

    Scaffold proteins organize many MAP kinase pathways by interacting with several components of these cascades. Recent studies suggest that scaffold proteins provide local activation platforms that contribute to signal specificity by insulating different MAP kinase pathways. PMID:11818078

  8. 48 CFR 2919.202 - Specific policies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SMALL BUSINESS AND SMALL DISADVANTAGED BUSINESS CONCERNS Policies 2919.202 Specific policies. Contracting officers, administrative officers and program management shall ensure that procurements are structured and conducted to afford small businesses the maximum practicable opportunity to participate in...

  9. Broadened diesel fuel specifications for rail applications

    SciTech Connect

    Cataldi, C.R.

    1988-01-01

    As the demand for distillate products increases, petroleum refiners find it increasingly expensive to meet the traditional specifications for jet and diesel fuels. Because those costs eventually show up in the price of fuel, the railroad industry has a diesel fuel research program to identify broadened specification fuels that cost less than standard fuels and which do not adversely affect engine performance or maintenance cost. Laboratory tests concentrated on cetane number, distillation range, and viscosity. The tests included 72 hours at idle speed, engine performance, and 500-hour endurance tests. Long-term field tests have verified the laboratory findings that cetane number can be reduced to 32 and 90 percent distillation point increased to 700/sup 0/F. Several railroads now have over three years of experience with broadened specification fuels in normal operations with no reported problems. With formal tests, some railroads have also relaxed their winter specifications for pour and cloud points.

  10. Secretin: specific binding to rat brain membranes

    SciTech Connect

    Fremeau, R.T. Jr.; Jensen, R.T.; Charlton, C.G.; Miller, R.L.; O'Donohue, T.L.; Moody, T.W.

    1983-08-01

    The binding of (/sup 125/I)secretin to rat brain membranes was investigated. Radiolabeled secretin bound with high affinity (KD . 0.2 nM) to a single class of noninteracting sites. Binding was specific, saturable, and reversible. Regional distribution studies indicated that the specific binding was greatest in the cerebellum, intermediate in the cortex, thalamus, striatum, hippocampus, and hypothalamus, and lowest in the midbrain and medulla/pons. Pharmacological studies indicated that only secretin, but not other peptides, inhibits binding of (/sup 125/I)secretin with high affinity. Also, certain guanine nucleotides inhibited high affinity binding. These data indicate that rat brain membranes possess high affinity binding sites specific for secretin and that with the use of (/sup 125/I) secretin the kinetics, stoichiometry, specificity, and distribution of secretin receptors can be directly investigated.

  11. Mission specification for three generic mission classes

    NASA Technical Reports Server (NTRS)

    1979-01-01

    Mission specifications for three generic mission classes are generated to provide a baseline for definition and analysis of data acquisition platform system concepts. The mission specifications define compatible groupings of sensors that satisfy specific earth resources and environmental mission objectives. The driving force behind the definition of sensor groupings is mission need; platform and space transportation system constraints are of secondary importance. The three generic mission classes are: (1) low earth orbit sun-synchronous; (2) geosynchronous; and (3) non-sun-synchronous, nongeosynchronous. These missions are chosen to provide a variety of sensor complements and implementation concepts. Each mission specification relates mission categories, mission objectives, measured parameters, and candidate sensors to orbits and coverage, operations compatibility, and platform fleet size.

  12. 2nd Generation ELT Performance Specification Development

    NASA Technical Reports Server (NTRS)

    Stimson, Chad M.

    2015-01-01

    NASA Search And Rescue is supporting RTCA SC-229 with research and recommendations for performance specifications for the 2nd generation of emergency locator transmitters. Areas for improvement and methods for collecting data will be presented.

  13. UPC Language Specifications V1.2

    SciTech Connect

    UPC Consortium

    2005-05-31

    UPC is an explicitly parallel extension to the ISO C 99Standard. UPC follows the partitioned global address space programming model. This document is the formal specification for the UPC language syntax and semantics.

  14. Patient-specific Modeling of Cardiovascular Mechanics

    PubMed Central

    Taylor, C.A.; Figueroa, C.A.

    2015-01-01

    Advances in numerical methods and three-dimensional imaging techniques have enabled the quantification of cardiovascular mechanics in subject-specific anatomic and physiologic models. Patient-specific models are being used to guide cell culture and animal experiments and test hypotheses related to the role of biomechanical factors in vascular diseases. Furthermore, biomechanical models based on noninvasive medical imaging could provide invaluable data on the in vivo service environment where cardiovascular devices are employed and the effect of the devices on physiologic function. Finally, the patient-specific modeling has enabled an entirely new application of cardiovascular mechanics, namely predicting outcomes of alternate therapeutic interventions for individual patients. We will review methods to create anatomic and physiologic models, obtain properties, assign boundary conditions, and solve the equations governing blood flow and vessel wall dynamics. Applications of patient-specific models of cardiovascular mechanics will be presented followed by a discussion of the challenges and opportunities that lie ahead. PMID:19400706

  15. 16 CFR 1212.15 - Specifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... under § 1212.14 are described in a written product specification. (Section 1212.4(c) requires that six... for each such dimension or force requirement. (3) Any further information, including, but not...

  16. 16 CFR 1210.15 - Specifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... described in a written product specification. (Section 1210.4(c) requires that six surrogate lighters be... the lighter, including the manufacturer's tolerances for each such dimension or force requirement....

  17. Specific Impulse Definition for Ablative Laser Propulsion

    NASA Technical Reports Server (NTRS)

    Herren, Kenneth A.; Gregory, Don A.

    2004-01-01

    The term "specific impulse" is so ingrained in the field of rocket propulsion that it is unlikely that any fundamental argument would be taken seriously for its removal. It is not an ideal measure but it does give an indication of the amount of mass flow (mass loss/time), as in fuel rate, required to produce a measured thrust over some time period This investigation explores the implications of being able to accurately measure the ablation rate and how the language used to describe the specific impulse results may have to change slightly, and recasts the specific impulse as something that is not a time average. It is not currently possible to measure the ablation rate accurately in real time so it is generally just assumed that a constant amount of material will be removed for each laser pulse delivered The specific impulse dependence on the ablation rate is determined here as a correction to the classical textbook definition.

  18. 48 CFR 36.202 - Specifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... technical societies. (c) When brand name or equal descriptions are necessary, specifications must clearly identify and describe the particular physical, functional, or other characteristics of the brand-name...

  19. 48 CFR 836.202 - Specifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... specifications. (b) During the design stage, contract architect-engineers must not use “brand name or equal” or.... This clause places bidders on notice that the “brand name or equal” provisions of the clause found...

  20. 48 CFR 36.202 - Specifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... technical societies. (c) When brand name or equal descriptions are necessary, specifications must clearly identify and describe the particular physical, functional, or other characteristics of the brand-name...

  1. Slicing AADL Specifications for Model Checking

    NASA Technical Reports Server (NTRS)

    Odenbrett, Maximilian; Nguyen, Viet Yen; Noll, Thomas

    2010-01-01

    To combat the state-space explosion problem in model checking larger systems, abstraction techniques can be employed. Here, methods that operate on the system specification before constructing its state space are preferable to those that try to minimize the resulting transition system as they generally reduce peak memory requirements. We sketch a slicing algorithm for system specifications written in (a variant of) the Architecture Analysis and Design Language (AADL). Given a specification and a property to be verified, it automatically removes those parts of the specification that are irrelevant for model checking the property, thus reducing the size of the corresponding transition system. The applicability and effectiveness of our approach is demonstrated by analyzing the state-space reduction for an example, employing a translator from AADL to Promela, the input language of the SPIN model checker.

  2. 50 CFR 216.105 - Specific regulations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS General Regulations Governing Small Takes of Marine Mammals Incidental to Specified Activities... mammals by harassment, serious injury, death or a combination thereof, specific regulations shall...

  3. 50 CFR 216.105 - Specific regulations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS General Regulations Governing Small Takes of Marine Mammals Incidental to Specified Activities... mammals by harassment, serious injury, death or a combination thereof, specific regulations shall...

  4. 50 CFR 216.105 - Specific regulations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS General Regulations Governing Small Takes of Marine Mammals Incidental to Specified Activities... mammals by harassment, serious injury, death or a combination thereof, specific regulations shall...

  5. 50 CFR 216.105 - Specific regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS General Regulations Governing Small Takes of Marine Mammals Incidental to Specified Activities... mammals by harassment, serious injury, death or a combination thereof, specific regulations shall...

  6. Specifications and programs for computer software validation

    NASA Technical Reports Server (NTRS)

    Browne, J. C.; Kleir, R.; Davis, T.; Henneman, M.; Haller, A.; Lasseter, G. L.

    1973-01-01

    Three software products developed during the study are reported and include: (1) FORTRAN Automatic Code Evaluation System, (2) the Specification Language System, and (3) the Array Index Validation System.

  7. Process Specification for Eddy Current Inspection

    NASA Technical Reports Server (NTRS)

    Koshti, Ajay

    2011-01-01

    This process specification establishes the minimum requirements for eddy current inspection of flat surfaces, fastener holes, threaded fasteners and seamless and welded tubular products made from nonmagnetic alloys such as aluminum and stainless steel.

  8. Specification For ST-5 Li Ion Battery

    NASA Technical Reports Server (NTRS)

    Castell, Karen D.; Day, John H. (Technical Monitor)

    2000-01-01

    This Specification defines the general requirements for rechargeable Space Flight batteries intended for use in the ST-5 program. The battery chemistry chosen for this mission is lithium ion (Li-Ion).

  9. 37 CFR 102.34 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... OF COMMERCE ADMINISTRATION DISCLOSURE OF GOVERNMENT INFORMATION Privacy Act § 102.34 Specific... required by Executive order to be kept secret in the interest of the national defense and foreign...

  10. 37 CFR 102.34 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... OF COMMERCE ADMINISTRATION DISCLOSURE OF GOVERNMENT INFORMATION Privacy Act § 102.34 Specific... required by Executive order to be kept secret in the interest of the national defense and foreign...

  11. 37 CFR 102.34 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... OF COMMERCE ADMINISTRATION DISCLOSURE OF GOVERNMENT INFORMATION Privacy Act § 102.34 Specific... required by Executive order to be kept secret in the interest of the national defense and foreign...

  12. FTP Extensions for Variable Protocol Specification

    NASA Technical Reports Server (NTRS)

    Allman, Mark; Ostermann, Shawn

    2000-01-01

    The specification for the File Transfer Protocol (FTP) assumes that the underlying network protocols use a 32-bit network address and a 16-bit transport address (specifically IP version 4 and TCP). With the deployment of version 6 of the Internet Protocol, network addresses will no longer be 32-bits. This paper species extensions to FTP that will allow the protocol to work over a variety of network and transport protocols.

  13. Specific Impulse and Mass Flow Rate Error

    NASA Technical Reports Server (NTRS)

    Gregory, Don A.

    2005-01-01

    Specific impulse is defined in words in many ways. Very early in any text on rocket propulsion a phrase similar to .specific impulse is the thrust force per unit propellant weight flow per second. will be found.(2) It is only after seeing the mathematics written down does the definition mean something physically to scientists and engineers responsible for either measuring it or using someone.s value for it.

  14. 25 CFR 515.12 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false Specific exemptions. 515.12 Section 515.12 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR GENERAL PROVISIONS PRIVACY ACT PROCEDURES § 515.12 Specific exemptions. (a) The following system of records is exempt from 5 U.S.C. 552a(c)(3), (d), (e)(1) and (f): Indian Gaming...

  15. 25 CFR 515.12 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Specific exemptions. 515.12 Section 515.12 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR GENERAL PROVISIONS PRIVACY ACT PROCEDURES § 515.12 Specific exemptions. (a) The following system of records is exempt from 5 U.S.C. 552a(c)(3), (d), (e)(1) and (f): Indian Gaming...

  16. 19 CFR 201.32 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Specific exemptions. 201.32 Section 201.32 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION GENERAL RULES OF GENERAL APPLICATION Safeguarding Individual Privacy Pursuant to 5 U.S.C. 552a § 201.32 Specific exemptions. (a) Pursuant to 5 U.S.C. 552a(k)(2), and in order to protect...

  17. 19 CFR 201.32 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 3 2011-04-01 2011-04-01 false Specific exemptions. 201.32 Section 201.32 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION GENERAL RULES OF GENERAL APPLICATION Safeguarding Individual Privacy Pursuant to 5 U.S.C. 552a § 201.32 Specific exemptions. (a) Pursuant to 5 U.S.C. 552a(k)(2), and in order to protect...

  18. Language translation, doman specific languages and ANTLR

    NASA Technical Reports Server (NTRS)

    Craymer, Loring; Parr, Terence

    2002-01-01

    We will discuss the features of ANTLR that make it an attractive tool for rapid developement of domain specific language translators and present some practical examples of its use: extraction of information from the Cassini Command Language specification, the processing of structured binary data, and IVL--an English-like language for generating VRML scene graph, which is used in configuring the jGuru.com server.

  19. Simple Benchmark Specifications for Space Radiation Protection

    NASA Technical Reports Server (NTRS)

    Singleterry, Robert C. Jr.; Aghara, Sukesh K.

    2013-01-01

    This report defines space radiation benchmark specifications. This specification starts with simple, monoenergetic, mono-directional particles on slabs and progresses to human models in spacecraft. This report specifies the models and sources needed to what the team performing the benchmark needs to produce in a report. Also included are brief descriptions of how OLTARIS, the NASA Langley website for space radiation analysis, performs its analysis.

  20. NORMAL LOAD BEARING BY SITE SPECIFIC CANISTER

    SciTech Connect

    NA

    2005-03-23

    The overall purpose of this calculation is to perform a preliminary analysis of the Site Specific Canister/Basket, subject to static gravity loads that include the self weight of the Canister Shell, the Basket, the Spent Nuclear Fuel, the Shield Plug and the related hardware, so that the loads are approximately known for sizing purposes. Based on these loads the stress levels in various components of the Site Specific Canister/Basket are evaluated.

  1. Autobiographical memory specificity in dissociative identity disorder.

    PubMed

    Huntjens, Rafaële J C; Wessel, Ineke; Hermans, Dirk; van Minnen, Agnes

    2014-05-01

    A lack of adequate access to autobiographical knowledge has been related to psychopathology. More specifically, patients suffering from depression or a history of trauma have been found to be characterized by overgeneral memory, in other words, they show a relative difficulty in retrieving a specific event from memory located in time and place. Previous studies of overgeneral memory have not included patients with dissociative disorders. These patients are interesting to consider, as they are hypothesized to have the ability to selectively compartmentalize information linked to negative emotions. This study examined avoidance and overgeneral memory in patients with dissociative identity disorder (DID; n = 12). The patients completed the autobiographical memory test (AMT). Their performance was compared with control groups of posttraumatic stress disorder (PTSD) patients (n = 26), healthy controls (n = 29), and DID simulators (n = 26). Specifically, we compared the performance of separate identity states in DID hypothesized to diverge in the use of avoidance as a coping strategy to deal with negative affect. No significant differences in memory specificity were found between the separate identities in DID. Irrespective of identity state, DID patients were characterized by a lack of memory specificity, which was similar to the lack of memory specificity found in PTSD patients. The converging results for DID and PTSD patients add empirical evidence for the role of overgeneral memory involved in the maintenance of posttraumatic psychopathology. PMID:24886016

  2. FOXA1 defines cancer cell specificity

    PubMed Central

    Zhang, Gaihua; Zhao, Yongbing; Liu, Yi; Kao, Li-Pin; Wang, Xiao; Skerry, Benjamin; Li, Zhaoyu

    2016-01-01

    A transcription factor functions differentially and/or identically in multiple cell types. However, the mechanism for cell-specific regulation of a transcription factor remains to be elucidated. We address how a single transcription factor, forkhead box protein A1 (FOXA1), forms cell-specific genomic signatures and differentially regulates gene expression in four human cancer cell lines (HepG2, LNCaP, MCF7, and T47D). FOXA1 is a pioneer transcription factor in organogenesis and cancer progression. Genomewide mapping of FOXA1 by chromatin immunoprecipitation sequencing annotates that target genes associated with FOXA1 binding are mostly common to these cancer cells. However, most of the functional FOXA1 target genes are specific to each cancer cell type. Further investigations using CRISPR-Cas9 genome editing technology indicate that cell-specific FOXA1 regulation is attributable to unique FOXA1 binding, genetic variations, and/or potential epigenetic regulation. Thus, FOXA1 controls the specificity of cancer cell types. We raise a “flower-blooming” hypothesis for cell-specific transcriptional regulation based on these observations. PMID:27034986

  3. Quantitative specificity-based display library screening identifies determinants of antibody-epitope binding specificity

    PubMed Central

    Hall, Sejal S; Daugherty, Patrick S

    2009-01-01

    Despite the critical importance of molecular specificity in bimolecular systems, in vitro display technologies have been applied extensively for affinity maturation of peptides and antibodies without explicitly measuring the specificity of the desired interaction. We devised a general strategy to measure, screen, and evolve specificity of protein ligand interactions analogous to widely used affinity maturation strategies. The specificity of binding to target and nontarget antibodies labeled with spectrally distinct fluorophores was measured simultaneously in protein mixtures via multiparameter flow cytometry, thereby enabling screening for high target antibody specificity. Isolated antibody specific ligands exhibited varying specificity, revealing critical amino acid determinants for target recognition and nontarget avoidance in complex mixtures. Molecular specificity in the mixture was further enhanced by quantitative directed evolution, yielding a family of epitopes exhibiting improved specificities equivalent, or superior to, the native peptide antigen to which the antibody was raised. Specificity screening simultaneously favored affinity, yielding ligands with three-fold improved affinity relative to the parent epitope. Quantitative specificity screening will be useful to screen, evolve, and characterize the specificity of protein and peptide interactions for molecular recognition applications. PMID:19610073

  4. Mechanisms of allergen-specific immunotherapy.

    PubMed

    Akdis, Mübeccel; Akdis, Cezmi A

    2007-04-01

    Allergen-specific immunotherapy (SIT) has been used for almost a century as a desensitizing therapy for allergic diseases and represents the only curative and specific method of treatment. Administration of appropriate concentrations of allergen extracts has been shown to be reproducibly effective when patients are carefully selected. The mechanisms by which allergen-SIT has its effects include the modulation of T-cell and B-cell responses and related antibody isotypes as well as effector cells of allergic inflammation, such as eosinophils, basophils, and mast cells. The balance between allergen-specific T-regulatory (Treg) and T(H)2 cells appears to be decisive in the development of allergic and healthy immune responses against allergens. Treg cells consistently represent the dominant subset specific for common environmental allergens in sensitized healthy individuals. In contrast, there is a high frequency of allergen-specific T(H)2 cells in patients with allergy. The induction of a tolerant state in peripheral T cells represents an essential step in allergen-SIT. Peripheral T-cell tolerance is characterized mainly by generation of allergen-specific Treg cells leading to suppressed T-cell proliferation and T(H)1 and T(H)2 cytokine responses against the allergen. This is accompanied by a significant increase in allergen-specific IgG(4), and also IgG(1) and IgA, and a decrease in IgE in the late stage of the disease. In addition, decreased tissue infiltration of mast cells and eosinophils and their mediator release including circulating basophils takes place. Current understanding of mechanisms of allergen-SIT, particularly the role of Treg cells in peripheral tolerance, may enable novel treatment strategies. PMID:17321578

  5. Producing specific milks for speciality cheeses.

    PubMed

    Bertoni, G; Calamari, L; Maianti, M G

    2001-05-01

    Protected denomination of origin (PDO) cheeses have distinctive sensorial characteristics. They can be made only from raw milk possessing specific features, which is processed through the 'art' of the cheesemaker. In general, the distinctive sensorial traits of PDO cheese cannot be achieved under different environmental-production conditions for two main reasons: (1) some milk features are linked to specific animal production systems; (2) cheese ripening is affected by the interaction between milk (specific) and the traditional technology applied to the transformation process (non-specific). Also, the environment for a good ripening stage can be quite specific and not reproducible. With reference to milk, factors of typicality are species and/or breed, pedoclimatic conditions, animal management system and feeding. Other factors that influence cheese quality are milk treatments, milk processing and the ripening procedures. The technology applied to most cheeses currently known as PDO utilizes only raw milk, rennet and natural lactic acid bacteria, so that milk must be, at its origin, suitable for processing. The specific milk characteristics that ensure a high success rate for PDO cheeses are high protein content and good renneting properties, appropriate fat content with appropriate fatty acid composition and the presence of chemical flavours originating from local feeds. Moreover, an appropriate microflora is also of major importance. The factors that contribute to achieving milk suitable for transformation into PDO cheese are genetics, age, lactation stage, season and climate, general management and health conditions, milking and particularly feeding, which affect nutrient availability, endocrine response and health status, and also the presence of microbes and chemical substances which enrich or reduce the milk-cheese quality. Many of these factors are regulated by the Producer Associations. However, the secret of the success of PDO cheeses is the combination of

  6. Chromosome-specific DNA Repeat Probes

    SciTech Connect

    Baumgartner, Adolf; Weier, Jingly Fung; Weier, Heinz-Ulrich G.

    2006-03-16

    In research as well as in clinical applications, fluorescence in situ hybridization (FISH) has gained increasing popularity as a highly sensitive technique to study cytogenetic changes. Today, hundreds of commercially available DNA probes serve the basic needs of the biomedical research community. Widespread applications, however, are often limited by the lack of appropriately labeled, specific nucleic acid probes. We describe two approaches for an expeditious preparation of chromosome-specific DNAs and the subsequent probe labeling with reporter molecules of choice. The described techniques allow the preparation of highly specific DNA repeat probes suitable for enumeration of chromosomes in interphase cell nuclei or tissue sections. In addition, there is no need for chromosome enrichment by flow cytometry and sorting or molecular cloning. Our PCR-based method uses either bacterial artificial chromosomes or human genomic DNA as templates with {alpha}-satellite-specific primers. Here we demonstrate the production of fluorochrome-labeled DNA repeat probes specific for human chromosomes 17 and 18 in just a few days without the need for highly specialized equipment and without the limitation to only a few fluorochrome labels.

  7. Disease-Specific Probabilistic Brain Atlases.

    PubMed

    Thompson, Paul; Mega, Michael S; Toga, Arthur W

    2000-06-11

    Atlases of the human brain, in health and disease, provide a comprehensive framework for understanding brain structure and function. The complexity and variability of brain structure, especially in the gyral patterns of the human cortex, present challenges in creating standardized brain atlases that reflect the anatomy of a population. This paper introduces the concept of a population-based, disease-specific brain atlas that can reflect the unique anatomy and physiology of a particular clinical subpopulation. Based on well-characterized patient groups, disease-specific atlases contain thousands of structure models, composite maps, average templates, and visualizations of structural variability, asymmetry and group-specific differences. They correlate the structural, metabolic, molecular and histologic hallmarks of the disease. Rather than simply fusing information from multiple subjects and sources, new mathematical strategies are introduced to resolve group-specific features not apparent in individual scans. High-dimensional elastic mappings, based on covariant partial differential equations, are developed to encode patterns of cortical variation. In the resulting brain atlas, disease-specific features and regional asymmetries emerge that are not apparent in individual anatomies. The resulting probabilistic atlas can identify patterns of altered structure and function, and can guide algorithms for knowledge-based image analysis, automated image labeling, tissue classification, data mining and functional image analysis. PMID:19424457

  8. Face recognition: a model specific ability

    PubMed Central

    Wilmer, Jeremy B.; Germine, Laura T.; Nakayama, Ken

    2014-01-01

    In our everyday lives, we view it as a matter of course that different people are good at different things. It can be surprising, in this context, to learn that most of what is known about cognitive ability variation across individuals concerns the broadest of all cognitive abilities; an ability referred to as general intelligence, general mental ability, or just g. In contrast, our knowledge of specific abilities, those that correlate little with g, is severely constrained. Here, we draw upon our experience investigating an exceptionally specific ability, face recognition, to make the case that many specific abilities could easily have been missed. In making this case, we derive key insights from earlier false starts in the measurement of face recognition’s variation across individuals, and we highlight the convergence of factors that enabled the recent discovery that this variation is specific. We propose that the case of face recognition ability illustrates a set of tools and perspectives that could accelerate fruitful work on specific cognitive abilities. By revealing relatively independent dimensions of human ability, such work would enhance our capacity to understand the uniqueness of individual minds. PMID:25346673

  9. Predicting tissue specific transcription factor binding sites

    PubMed Central

    2013-01-01

    Background Studies of gene regulation often utilize genome-wide predictions of transcription factor (TF) binding sites. Most existing prediction methods are based on sequence information alone, ignoring biological contexts such as developmental stages and tissue types. Experimental methods to study in vivo binding, including ChIP-chip and ChIP-seq, can only study one transcription factor in a single cell type and under a specific condition in each experiment, and therefore cannot scale to determine the full set of regulatory interactions in mammalian transcriptional regulatory networks. Results We developed a new computational approach, PIPES, for predicting tissue-specific TF binding. PIPES integrates in vitro protein binding microarrays (PBMs), sequence conservation and tissue-specific epigenetic (DNase I hypersensitivity) information. We demonstrate that PIPES improves over existing methods on distinguishing between in vivo bound and unbound sequences using ChIP-seq data for 11 mouse TFs. In addition, our predictions are in good agreement with current knowledge of tissue-specific TF regulation. Conclusions We provide a systematic map of computationally predicted tissue-specific binding targets for 284 mouse TFs across 55 tissue/cell types. Such comprehensive resource is useful for researchers studying gene regulation. PMID:24238150

  10. Main factors providing specificity of repair enzymes.

    PubMed

    Nevinsky, G A

    2011-01-01

    Specific and nonspecific DNA complex formation with human uracil-DNA glycosylase, 8-oxoguanine-DNA glycosylase, and apurine/apyrimidine endonuclease, as well as with E. coli 8-oxoguanine-DNA glycosylase and RecA protein was analyzed using the method of stepwise increase in DNA-ligand complexity. It is shown that high affinity of these enzymes to any DNA (10(-4)-10(-8) M) is provided by a large number of weak additive contacts mainly with DNA internucleoside phosphate groups and in a less degree with bases of nucleotide links "covered" by protein globules. Enzyme interactions with specific DNA links are comparable in efficiency with weak unspecific contacts and provide only for one-two orders of affinity (10(-1)-10(-2) M), but these contacts are extremely important at stages of DNA and enzyme structural adaptation and catalysis proper. Only in the case of specific DNA individual for each enzyme alterations in DNA structure provide for efficient adjustment of reacting enzyme atoms and DNA orbitals with accuracy up to 10-15° and, as a result, for high reaction rate. Upon transition from nonspecific to specific DNA, reaction rate (k(cat)) increases by 4-8 orders of magnitude. Thus, stages of DNA and enzyme structural adaptation as well as catalysis proper are the basis of specificity of repair enzymes. PMID:21568843

  11. A differential equation for specific catchment area

    NASA Astrophysics Data System (ADS)

    Gallant, John C.; Hutchinson, Michael F.

    2011-05-01

    Analysis of the behavior of specific catchment area in a stream tube leads to a simple nonlinear differential equation describing the rate of change of specific catchment area along a flow path. The differential equation can be integrated numerically along a flow path to calculate specific catchment area at any point on a digital elevation model without requiring the usual estimates of catchment area and width. The method is more computationally intensive than most grid-based methods for calculating specific catchment area, so its main application is as a reference against which conventional methods can be tested. This is the first method that provides a benchmark for more approximate methods in complex terrain with both convergent and divergent areas, not just on simple surfaces for which analytical solutions are known. Preliminary evaluation of the D8, M8, digital elevation model networks (DEMON), and D∞ methods indicate that the D∞ method is the best of those methods for estimating specific catchment area, but all methods overestimate in divergent terrain.

  12. Face recognition: a model specific ability.

    PubMed

    Wilmer, Jeremy B; Germine, Laura T; Nakayama, Ken

    2014-01-01

    In our everyday lives, we view it as a matter of course that different people are good at different things. It can be surprising, in this context, to learn that most of what is known about cognitive ability variation across individuals concerns the broadest of all cognitive abilities; an ability referred to as general intelligence, general mental ability, or just g. In contrast, our knowledge of specific abilities, those that correlate little with g, is severely constrained. Here, we draw upon our experience investigating an exceptionally specific ability, face recognition, to make the case that many specific abilities could easily have been missed. In making this case, we derive key insights from earlier false starts in the measurement of face recognition's variation across individuals, and we highlight the convergence of factors that enabled the recent discovery that this variation is specific. We propose that the case of face recognition ability illustrates a set of tools and perspectives that could accelerate fruitful work on specific cognitive abilities. By revealing relatively independent dimensions of human ability, such work would enhance our capacity to understand the uniqueness of individual minds. PMID:25346673

  13. Statistical considerations in setting product specifications.

    PubMed

    Dong, Xiaoyu; Tsong, Yi; Shen, Meiyu

    2015-01-01

    According to ICH Q6A (1999), a specification is defined as a list of tests, references to analytical procedures, and appropriate acceptance criteria, which are numerical limits, ranges, or other criteria for the tests described. For drug products, specifications usually consist of test methods and acceptance criteria for assay, impurities, pH, dissolution, moisture, and microbial limits, depending on the dosage forms. They are usually proposed by the manufacturers and subject to the regulatory approval for use. When the acceptance criteria in product specifications cannot be pre-defined based on prior knowledge, the conventional approach is to use data from a limited number of clinical batches during the clinical development phases. Often in time, such acceptance criterion is set as an interval bounded by the sample mean plus and minus two to four standard deviations. This interval may be revised with the accumulated data collected from released batches after drug approval. In this article, we describe and discuss the statistical issues of commonly used approaches in setting or revising specifications (usually tighten the limits), including reference interval, (Min, Max) method, tolerance interval, and confidence limit of percentiles. We also compare their performance in terms of the interval width and the intended coverage. Based on our study results and review experiences, we make some recommendations on how to select the appropriate statistical methods in setting product specifications to better ensure the product quality. PMID:25358110

  14. GRB10 imprinting is eutherian mammal specific.

    PubMed

    Stringer, Jessica M; Suzuki, Shunsuke; Pask, Andrew J; Shaw, Geoff; Renfree, Marilyn B

    2012-12-01

    GRB10 is an imprinted gene differently expressed from two promoters in mouse and human. Mouse Grb10 is maternally expressed from the major promoter in most tissues and paternally expressed from the brain-specific promoter within specific regions of the fetal and adult central nervous system. Human GRB10 is biallelically expressed from the major promoter in most tissues except in the placental villus trophoblast where it is maternally expressed, whereas the brain-specific promoter is paternally expressed in the fetal brain. This study characterized the ortholog of GRB10 in a marsupial, the tammar wallaby (Macropus eugenii) to investigate the origin and evolution of imprinting at this locus. The protein coding exons and predicted amino acid sequence of tammar GRB10 were highly conserved with eutherian GRB10. The putative first exon, which is located in the orthologous region to the eutherian major promoter, was found in the tammar, but no exon was found in the downstream region corresponding to the eutherian brain-specific promoter, suggesting that marsupials only have a single promoter. Tammar GRB10 was widely expressed in various tissues including the brain but was not imprinted in any of the tissues examined. Thus, it is likely that GRB10 imprinting evolved in eutherians after the eutherian-marsupial divergence approximately 160 million years ago, subsequent to the acquisition of a brain-specific promoter, which resides within the imprinting control region in eutherians. PMID:22787282

  15. Disease-Specific Probabilistic Brain Atlases

    PubMed Central

    Thompson, Paul; Mega, Michael S.; Toga, Arthur W.

    2009-01-01

    Atlases of the human brain, in health and disease, provide a comprehensive framework for understanding brain structure and function. The complexity and variability of brain structure, especially in the gyral patterns of the human cortex, present challenges in creating standardized brain atlases that reflect the anatomy of a population. This paper introduces the concept of a population-based, disease-specific brain atlas that can reflect the unique anatomy and physiology of a particular clinical subpopulation. Based on well-characterized patient groups, disease-specific atlases contain thousands of structure models, composite maps, average templates, and visualizations of structural variability, asymmetry and group-specific differences. They correlate the structural, metabolic, molecular and histologic hallmarks of the disease. Rather than simply fusing information from multiple subjects and sources, new mathematical strategies are introduced to resolve group-specific features not apparent in individual scans. High-dimensional elastic mappings, based on covariant partial differential equations, are developed to encode patterns of cortical variation. In the resulting brain atlas, disease-specific features and regional asymmetries emerge that are not apparent in individual anatomies. The resulting probabilistic atlas can identify patterns of altered structure and function, and can guide algorithms for knowledge-based image analysis, automated image labeling, tissue classification, data mining and functional image analysis. PMID:19424457

  16. AWS breaks new ground with soldering specification.

    SciTech Connect

    Vianco, Paul Thomas

    2008-08-01

    Joining technologies continue to advance with new materials, process innovations, and inspection techniques. An increasing number of high-valued, high-reliability applications -- from boilers and ship hulls to rocket motors and medical devices -- have required the development of industry standards and specifications in order to ensure that the best design and manufacturing practices are being used to produce safe, durable products and assemblies. Standards writing has always had an important role at the American Welding Society (AWS). The AWS standards and specifications cover such topics as filler materials, joining processes, inspection techniques, and qualification methods that are used in welding and brazing technologies. These AWS standards and specifications, all of which are approved by the American National Standards Institute (ANSI), have also provided the basis for many similar documents used in Europe and in Pacific Rim countries.

  17. Redesigning Trypsin: Alteration of Substrate Specificity

    NASA Astrophysics Data System (ADS)

    Craik, Charles S.; Largman, Corey; Fletcher, Thomas; Roczniak, Steven; Barr, Philip J.; Fletterick, Robert; Rutter, William J.

    1985-04-01

    A general method for modifying eukaryotic genes by site-specific mutagenesis and subsequent expression in mammalian cells was developed to study the relation between structure and function of the proteolytic enzyme trypsin. Glycine residues at positions 216 and 226 in the binding cavity of trypsin were replaced by alanine residues, resulting in three trypsin mutants. Computer graphic analysis suggested that these substitutions would differentially affect arginine and lysine substrate binding of the enzyme. Although the mutant enzymes were reduced in catalytic rate, they showed enhanced substrate specificity relative to the native enzyme. This increased specificity was achieved by the unexpected differential effects on the catalytic activity toward arginine and lysine substrates. Mutants containing alanine at position 226 exhibited an altered conformation that may be converted to a trypsin-like structure upon binding of a substrate analog.

  18. Maintained generalization of delay-specific remembering.

    PubMed

    White, K Geoffrey; Sargisson, Rebecca J

    2011-07-01

    According to the discrimination hypothesis (White, 2002), remembering is a delay-specific discrimination made at the time of retrieval. In the present experiment the delay-specific nature of the discrimination was made explicit by making correct choices in a delayed matching-to-sample task performed by pigeons conditional on whether the retention interval was short or long. Retention interval was varied over several durations in a maintained generalization test without reinforcement for correct matching responses. Opposing gradients demonstrated generalization of delay-specific remembering, consistent with the view that the temporal dimension of the retention interval can be treated in the same way as non-temporal dimensions of the sample stimulus. PMID:21704683

  19. Analysis of specificity in immunoelectron microscopy.

    PubMed

    Hacker, Christian; Lucocq, John M

    2014-01-01

    Immunoelectron microscopy (immuno-EM) using gold labeling on sections is a powerful technique for mapping the distribution of proteins, lipids, carbohydrates, and nucleic acids in intact biological systems. The gold particles comprise a useful and readily quantifiable digital readout. Simply applying a labeling reagent (antibody or other affinity probe) to an ultrathin section yields a pattern of gold signal over the biological structures displayed in the section. This initial (raw) distribution of gold signal contains both specific and nonspecific labeling. Here we describe a method for removing nonspecific labeling to leave the target-specific signal. This specific labeling distribution better reflects the "real" distribution of the cell component of interest. PMID:24357369

  20. Cell specific, variable density, polymer microspheres

    NASA Technical Reports Server (NTRS)

    Yen, Shiao-Ping S. (Inventor); Rembaum, Alan (Inventor); Molday, Robert S. (Inventor)

    1978-01-01

    Biocompatible polymeric microspheres having an average diameter below about 3 microns and having a density at least 15% greater or lesser than organic cells and having covalent binding sites are provided in accordance with this invention. The microspheres are obtained by copolymerizing a hydroxy or amine substituted acrylic monomer such as hydroxyethylmethacrylate with a light or dense comonomer such as a fluoromonomer. A lectin or antibody is bound to the hydroxy or amine site of the bead to provide cell specificity. When added to a cell suspension the marked bead will specifically label the cell membrane by binding to specific receptor sites thereon. The labelled membrane can then be separated by density gradient centrifugation.

  1. Mode specificity in unimolecular reaction dynamics

    SciTech Connect

    Waite, B.A.

    1982-07-01

    Theoretical studies on mode specificity in unimolecular reaction dynamics are presented, based on essentially exact quantum mechanical methods, a semi-classical multichannel branching model, and classical trajectory methods. The principal aim is to discover the relevant factors governing whether a unimolecular system exhibits mode specificity in its individual state rate constants, i.e., whether quasi-degenerate metastable states decay with significantly different rates. Model studies of two nonlinearly coupled oscillators (one of which can dissociate) demonstrate the effects of various features of potential energy surfaces on the character of the rates (e.g., degeneracy of modes, reaction path curvature, frequency modulation, etc.). These results and those obtained for the Henon-Heiles potential energy surface indicate and apparent absence of correlation between the quasi-periodic/ergodic motion of classical mechanics and the mode specific/statistical behavior of the unimolecular rate constants.

  2. Specific Immunosuppression by Immunotoxins Containing Daunomycin

    NASA Astrophysics Data System (ADS)

    Diener, E.; Diner, U. E.; Sinha, A.; Xie, S.; Vergidis, R.

    1986-01-01

    Daunomycin, when conjugated with a targeting antigen by an acid-sensitive spacer, remains inactive at the intravascular pH of 7 but becomes active after cleavage within the acidic lysosomal environment of the target cell. This observation made it possible to construct cytocidal compounds that caused antigen-specific suppression of murine lymphocyte function. When daunomycin was coupled to the hapten conjugate of ovalbumin by an acid-sensitive cis-aconityl group, it caused hapten-specific impairment of immunocompetence in murine B lymphocytes in vitro and in vivo. Furthermore, the response by T lymphocytes to concanavalin A in vitro was selectively eliminated by a conjugate between daunomycin plus the acid-sensitive spacer and a monoclonal antibody specific for T cells.

  3. Spent nuclear fuel project product specification

    SciTech Connect

    Pajunen, A.L.

    1998-01-30

    Product specifications are limits and controls established for each significant parameter that potentially affects safety and/or quality of the Spent Nuclear Fuel (SNF) packaged for transport to dry storage. The product specifications in this document cover the spent fuel packaged in MultiCanister Overpacks (MCOs) to be transported throughout the SNF Project. The SNF includes N Reactor fuel and single-pass reactor fuel. The FRS removes the SNF from the storage canisters, cleans it, and places it into baskets. The MCO loading system places the baskets into MCO/Cask assembly packages. These packages are then transferred to the Cold Vacuum Drying (CVD) Facility. After drying at the CVD Facility, the MCO cask packages are transferred to the Canister Storage Building (CSB), where the MCOs are removed from the casks, staged, inspected, sealed (by welding), and stored until a suitable permanent disposal option is implemented. The key criteria necessary to achieve these goals are documented in this specification.

  4. Assessing Specificity of Anticancer Drugs In Vitro.

    PubMed

    Kluwe, Lan

    2016-01-01

    A procedure for assessing specificity of anticancer drugs in vitro using cultures containing both tumor and non-tumor cells is demonstrated. The key element is the quantitative determination of a tumor-specific genetic alteration in relation to a universal sequence using a dual-probe digital PCR assay and the subsequent calculation of the proportion of tumor cells. The assay is carried out on a culture containing tumor cells of an established line and spiked-in non-tumor cells. The mixed culture is treated with a test drug at various concentrations. After the treatment, DNA is prepared directly from the survived adhesive cells in wells of 96-well plates using a simple and inexpensive method, and subjected to a dual-probe digital PCR assay for measuring a tumor-specific genetic alteration and a reference universal sequence. In the present demonstration, a heterozygous deletion of the NF1 gene is used as the tumor-specific genetic alteration and a RPP30 gene as the reference gene. Using the ratio NF1/RPP30, the proportion of tumor cells was calculated. Since the dose-dependent change of the proportion of tumor cells provides an in vitro indication for specificity of the drug, this genetic and cell-based in vitro assay will likely have application potential in drug discovery. Furthermore, for personalized cancer-care, this genetic- and cell-based tool may contribute to optimizing adjuvant chemotherapy by means of testing efficacy and specificity of candidate drugs using primary cultures of individual tumors. PMID:27078035

  5. Disease Specific Productivity of American Cancer Hospitals

    PubMed Central

    Goldstein, Jeffery A.; Prasad, Vinay

    2015-01-01

    Context Research-oriented cancer hospitals in the United States treat and study patients with a range of diseases. Measures of disease specific research productivity, and comparison to overall productivity, are currently lacking. Hypothesis Different institutions are specialized in research of particular diseases. Objective To report disease specific productivity of American cancer hospitals, and propose a summary measure. Method We conducted a retrospective observational survey of the 50 highest ranked cancer hospitals in the 2013 US News and World Report rankings. We performed an automated search of PubMed and Clinicaltrials.gov for published reports and registrations of clinical trials (respectively) addressing specific cancers between 2008 and 2013. We calculated the summed impact factor for the publications. We generated a summary measure of productivity based on the number of Phase II clinical trials registered and the impact factor of Phase II clinical trials published for each institution and disease pair. We generated rankings based on this summary measure. Results We identified 6076 registered trials and 6516 published trials with a combined impact factor of 44280.4, involving 32 different diseases over the 50 institutions. Using a summary measure based on registered and published clinical trails, we ranked institutions in specific diseases. As expected, different institutions were highly ranked in disease-specific productivity for different diseases. 43 institutions appeared in the top 10 ranks for at least 1 disease (vs 10 in the overall list), while 6 different institutions were ranked number 1 in at least 1 disease (vs 1 in the overall list). Conclusion Research productivity varies considerably among the sample. Overall cancer productivity conceals great variation between diseases. Disease specific rankings identify sites of high academic productivity, which may be of interest to physicians, patients and researchers. PMID:25781329

  6. Assessing Specificity of Anticancer Drugs In Vitro

    PubMed Central

    Kluwe, Lan

    2016-01-01

    A procedure for assessing specificity of anticancer drugs in vitro using cultures containing both tumor and non-tumor cells is demonstrated. The key element is the quantitative determination of a tumor-specific genetic alteration in relation to a universal sequence using a dual-probe digital PCR assay and the subsequent calculation of the proportion of tumor cells. The assay is carried out on a culture containing tumor cells of an established line and spiked-in non-tumor cells. The mixed culture is treated with a test drug at various concentrations. After the treatment, DNA is prepared directly from the survived adhesive cells in wells of 96-well plates using a simple and inexpensive method, and subjected to a dual-probe digital PCR assay for measuring a tumor-specific genetic alteration and a reference universal sequence. In the present demonstration, a heterozygous deletion of the NF1 gene is used as the tumor-specific genetic alteration and a RPP30 gene as the reference gene. Using the ratio NF1/RPP30, the proportion of tumor cells was calculated. Since the dose-dependent change of the proportion of tumor cells provides an in vitro indication for specificity of the drug, this genetic and cell-based in vitro assay will likely have application potential in drug discovery. Furthermore, for personalized cancer-care, this genetic- and cell-based tool may contribute to optimizing adjuvant chemotherapy by means of testing efficacy and specificity of candidate drugs using primary cultures of individual tumors. PMID:27078035

  7. [Substrate specificity and action mechanism of glycosidases].

    PubMed

    Borzova, N V; Varbanets', L D

    2005-01-01

    Result of author's research and data from literature have been generalized with respect to hydrolase and transferase activity of glycosidases: alpha-galactosidase and alpha-N-acetylgalactosaminidase--the enzymes which catalyse hydrolysis of natural and synthetic glycosides. Broad variability of action specificity of glycosidases with respect to glycon, aglycon as well as the bond type depending on the enzyme isolation source have been shown. One can suppose that the enzyme action specificity is connected with different formation mechanisms of enzyme-substrate complexes. An idea is discussed concerning the identity of the mechanism of splitting of various glycosidic links by the studied enzymes. PMID:15765886

  8. Thermodynamic basis of site-specific cooperativity.

    PubMed

    Di Cera, E

    1994-08-01

    Cooperative phenomena in biological macromolecules arise from the interaction of many distinct subsystems, such as structural domains or binding sites. Cooperative properties of the system as a whole, like protein folding or allosteric transitions, are subject to the restrictions imposed by thermodynamic stability. These restrictions, however, do not apply in the case of individual subsystems open to interactions with the rest of the macromolecule. The site-specific properties of such subsystems can be understood in general thermodynamic terms from those of a multicomponent system under particular conditions. The analogy provides a thermodynamic basis for site-specific cooperativity. PMID:8075382

  9. Engineered waste-package-system design specification

    SciTech Connect

    Not Available

    1983-05-01

    This report documents the waste package performance requirements and geologic and waste form data bases used in developing the conceptual designs for waste packages for salt, tuff, and basalt geologies. The data base reflects the latest geotechnical information on the geologic media of interest. The parameters or characteristics specified primarily cover spent fuel, defense high-level waste, and commercial high-level waste forms. The specification documents the direction taken during the conceptual design activity. A separate design specification will be developed prior to the start of the preliminary design activity.

  10. Technical specifications - enhancing the safety impact

    SciTech Connect

    Not Available

    1983-11-01

    This report documents the work of an interoffice, interdisciplinary, NRC Task Group established in August 1983 to identify the scope and nature of problems with surveillance testing in current Technical Specifications and to develop alternative approaches that will provide better assurance that surveillance testing does not adversely impact safety. The Task Group concluded that some of the Technical Specifications have the potential for adversely affecting safety and some do not appear to be cost effective. The Task Group developed five recommendations for improvement. 15 references.

  11. Especial skills: specificity embedded within generality.

    PubMed

    Keetch, Katherine M; Lee, Timothy D; Schmidt, Richard A

    2008-12-01

    Recent evidence suggests that massive amounts of practice of the basketball free throw (a "set shot") results in the development of a specific memory representation that is unique to this one shot distance and angle, and that is distinct from set shots taken at locations other than the free throw line. We termed this unique capability an especial skill. In this article, we review the evidence and provide new data regarding the existence of especial skills. These findings are discussed in terms of their implications for motor control theory and in terms of the broader context of specificity versus generality in the learning of motor skills. PMID:19164838

  12. Software engineering with application-specific languages

    NASA Technical Reports Server (NTRS)

    Campbell, David J.; Barker, Linda; Mitchell, Deborah; Pollack, Robert H.

    1993-01-01

    Application-Specific Languages (ASL's) are small, special-purpose languages that are targeted to solve a specific class of problems. Using ASL's on software development projects can provide considerable cost savings, reduce risk, and enhance quality and reliability. ASL's provide a platform for reuse within a project or across many projects and enable less-experienced programmers to tap into the expertise of application-area experts. ASL's have been used on several software development projects for the Space Shuttle Program. On these projects, the use of ASL's resulted in considerable cost savings over conventional development techniques. Two of these projects are described.

  13. DOE site-specific threat assessment

    SciTech Connect

    West, D.J.; Al-Ayat, R.A.; Judd, B.R.

    1985-07-12

    A facility manager faced with the challenges of protecting a nuclear facility against potential threats must consider the likelihood and consequences of such threats, know the capabilities of the facility safeguards and security systems, and make informed decisions about the cost-effectivness of safeguards and security upgrades. To help meet these challenges, the San Francisco Operations Office of the Department of Energy, in conjunction with the Lawrence Livermore Laboratory, has developed a site-specific threat assessment approach and a quantitative model to improve the quality and consistency of site-specific threat assessment and resultant security upgrade decisions at sensitive Department of Energy facilities. 5 figs.

  14. [The synthesis of specific enzyme inhibitors].

    PubMed

    Iakovleva, G M

    1987-04-01

    The review deals with directed synthesis of specific enzyme inhibitors. They are classified within the framework of the mechanistic approach, namely, stable analogues of substrates, which form enzyme complexes mimicking the Michaelis complex or those which influence the chemical stages of enzyme catalysis; conformational inhibitors; substrate analogues participating in enzyme reactions and producing modified products; suicide inhibitors; stage inhibitors (inhibitors influencing certain stages of enzyme reaction); transition state analogues; multisubstrate analogues and collected substrates. Types of chemical modification used in synthesis of the specific inhibitors are discussed. Some possibilities of the quantity structure-activity relationship methods, computer modelling and molecular graphics in designing the optimal structure of inhibitors are mentioned. PMID:3300658

  15. Interactive specification acquisition via scenarios: A proposal

    NASA Technical Reports Server (NTRS)

    Hall, Robert J.

    1992-01-01

    Some reactive systems are most naturally specified by giving large collections of behavior scenarios. These collections not only specify the behavior of the system, but also provide good test suites for validating the implemented system. Due to the complexity of the systems and the number of scenarios, however, it appears that automated assistance is necessary to make this software development process workable. Interactive Specification Acquisition Tool (ISAT) is a proposed interactive system for supporting the acquisition and maintenance of a formal system specification from scenarios, as well as automatic synthesis of control code and automated test generation. This paper discusses the background, motivation, proposed functions, and implementation status of ISAT.

  16. Spent Nuclear Fuel (SNF) Project Product Specification

    SciTech Connect

    PAJUNEN, A.L.

    2000-12-07

    The process for removal of Spent Nuclear Fuel (SNF) from the K Basins has been divided into major sub-systems. The Fuel Retrieval System (FRS) removes fuel from the existing storage canisters, cleans it, and places it into baskets. The multi-canister overpack (MCO) loading system places the baskets into an MCO that has been pre-loaded in a cask. The cask, containing a loaded MCO, is then transferred to the Cold Vacuum Drying (CVD) Facility. After drying at the CVD Facility, the cask, and MCO, are transferred to the Canister Storage Building (CSB), where the MCO is removed from the cask, staged, inspected, sealed (by welding), and stored until a suitable permanent disposal option is implemented. The purpose of this document is to specify the process related characteristics of an MCO at the interface between major process systems. The characteristics are derived from the primary technical documents that form the basis for safety analysis and design calculations. This document translates the calculation assumptions into implementation requirements and describes the method of verifying that the requirement is achieved. These requirements are used to define validation test requirements and describe requirements that influence multiple sub-project safety analysis reports. This product specification establishes limits and controls for each significant process parameter at interfaces between major sub-systems that potentially affect the overall safety and/or quality of the SNF packaged for processing, transport, and interim dry storage. The product specifications in this document cover the SNF packaged in MCOs to be transported throughout the SNF Project. The description of the product specifications are organized in the document as follows: Section 2.0--Summary listing of product specifications at each major sub-system interface. Section 3.0--Summary description providing guidance as to how specifications are complied with by equipment design or processing within a major

  17. Molecular specific optoacoustic imaging with plasmonic nanoparticles

    NASA Astrophysics Data System (ADS)

    Mallidi, Srivalleesha; Larson, Timothy; Aaron, Jesse; Sokolov, Konstantin; Emelianov, Stanislav

    2007-05-01

    Gold nanoparticles functionalized with antibodies can specifically bind to molecular biomarkers such as epithelial growth factor receptor (EGFR). The molecule specific nature of the antibody-functionalized gold nanoparticles forms the basis for the developed optoacoustic imaging technique to detect cancer at an asymptotic stage. Optoacoustic imaging was performed with 532 nm and 680 nm pulsed laser irradiation on three-dimensional tissue phantoms prepared using a human keratinocyte cell line. The results of our study demonstrate that the combination of anti-EGFR gold ioconjugates and optoacoustic imaging can allow highly sensitive and selective detection of human epithelial cancer cells.

  18. Specific optical rotation indicatrices of chitosan films

    NASA Astrophysics Data System (ADS)

    Rudenko, Darya A.; Shipovskaya, Anna B.

    2016-04-01

    The optical activity of chitosan films in the forms of polysalt (chitosan acetate) and polybase was studied. The specific optical rotation [α] of all our films was negative. The absolute values of [α] of polybasic chitosan films was by an order of magnitude higher than that for polysalt films. A dependence of [α] on the orientation angle of the sample relative to the direction of the polarization vector of the incident light beam in the plane perpendicular to this beam was established. Specific optical rotation indicatrices of the chitosan films of both chemical forms were plotted.

  19. Diffraction-Specific Fringe Computation for Electro -

    NASA Astrophysics Data System (ADS)

    Lucente, Mark

    Diffraction-specific fringe computation is a novel system for the generation of holographic fringe patterns for real-time display. This thesis describes the development, implementation, and analysis of diffraction-specific computation, an approach that considers the reconstruction process rather than the interference process in optical holography. The primary goal is to increase the speed of holographic computation for real-time three-dimensional electro-holographic (holovideo) displays. Diffraction-specific fringe computation is based on the discretization of space and spatial frequency in the fringe pattern. Two holographic fringe encoding techniques are developed from diffraction-specific fringe computation and applied to make most efficient use of hologram channel capacity. A "hogel-vector encoding" technique is based on undersampling the fringe spectra. A "fringelet encoding" technique is designed to increase the speed and simplicity of decoding. The analysis of diffraction-specific computation focuses on the trade-offs between compression ratio, image fidelity, and image depth. The decreased image resolution (increased point spread) that is introduced into holographic images due to encoding is imperceptible to the human visual system under certain conditions. A compression ratio of 16 is achieved (using either encoding method) with an acceptably small loss in image resolution. Total computation time is reduced by a factor of over 100 to less than 7.0 seconds per 36-MB holographic fringe using the fringelet encoding method. Diffraction-specific computation more efficiently matches the information content of holographic fringes to the human visual system. Diffraction-specific holographic encoding allows for "visual-bandwidth holography," i.e., holographic imaging that requires a bandwidth commensurate with the usable visual information contained in an image. Diffraction -specific holographic encoding enables the integration of holographic information with other

  20. [Development of domain specific search engines].

    PubMed

    Takai, T; Tokunaga, M; Maeda, K; Kaminuma, T

    2000-01-01

    As cyber space exploding in a pace that nobody has ever imagined, it becomes very important to search cyber space efficiently and effectively. One solution to this problem is search engines. Already a lot of commercial search engines have been put on the market. However these search engines respond with such cumbersome results that domain specific experts can not tolerate. Using a dedicate hardware and a commercial software called OpenText, we have tried to develop several domain specific search engines. These engines are for our institute's Web contents, drugs, chemical safety, endocrine disruptors, and emergent response for chemical hazard. These engines have been on our Web site for testing. PMID:11534132

  1. Nutrient-Specific Foraging in Invertebrate Predators

    NASA Astrophysics Data System (ADS)

    Mayntz, David; Raubenheimer, David; Salomon, Mor; Toft, Søren; Simpson, Stephen J.

    2005-01-01

    Many herbivores and omnivores adjust their food selection behavior to regulate the intake of multiple nutrients. Carnivores, however, are generally assumed to optimize the rate of prey capture rather than select prey according to nutrient composition. We showed experimentally that invertebrate predators can forage selectively for protein and lipids to redress specific nutritional imbalances. This selection can take place at different stages of prey handling: The predator may select among foods of different nutritional composition, eat more of a prey if it is rich in nutrients that the predator is deficient in, or extract specific nutrients from a single prey item.

  2. Site-Specific Infrared Probes of Proteins

    PubMed Central

    Ma, Jianqiang; Pazos, Ileana M.; Zhang, Wenkai; Culik, Robert M.; Gai, Feng

    2015-01-01

    Infrared spectroscopy has played an instrumental role in studying a wide variety of biological questions. However, in many cases it is impossible or difficult to rely on the intrinsic vibrational modes of biological molecules of interest, such as proteins, to reveal structural and/or environmental information in a site-specific manner. To overcome this limitation, many recent efforts have been dedicated to the development and application of various extrinsic vibrational probes that can be incorporated into biological molecules and used to site-specifically interrogate their structural and/or environmental properties. In this Review, we highlight some recent advancements of this rapidly growing research area. PMID:25580624

  3. Specificity, Transfer, and the Development of Expertise

    ERIC Educational Resources Information Center

    Brookes, David T.; Ross, Brian H.; Mestre, Jose P.

    2011-01-01

    In this paper we present the results of two experiments designed to understand how physics students' learning of the concept of refraction is influenced by the cognitive phenomenon of "specificity." In both experiments participants learned why light bends as it travels from one optical medium to another with an analogy made to a car driving from…

  4. 48 CFR 636.202 - Specifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Specifications. 636.202 Section 636.202 Federal Acquisition Regulations System DEPARTMENT OF STATE SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Special Aspects of Contracting for Construction...

  5. 31 CFR 539.311 - Specific license.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Specific license. 539.311 Section 539.311 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY WEAPONS OF MASS DESTRUCTION TRADE CONTROL...

  6. 31 CFR 539.311 - Specific license.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Specific license. 539.311 Section 539.311 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY WEAPONS OF MASS DESTRUCTION TRADE CONTROL...

  7. 31 CFR 539.311 - Specific license.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Specific license. 539.311 Section 539.311 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY WEAPONS OF MASS DESTRUCTION TRADE CONTROL...

  8. 31 CFR 539.311 - Specific license.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Specific license. 539.311 Section 539.311 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY WEAPONS OF MASS DESTRUCTION TRADE CONTROL...

  9. 31 CFR 539.311 - Specific license.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Specific license. 539.311 Section 539.311 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY WEAPONS OF MASS DESTRUCTION TRADE CONTROL...

  10. 50 CFR 648.165 - Framework specifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Atlantic Bluefish Fishery § 648.165 Framework specifications. (a) Within season management action. The..., recreational possession limit, recreational season, closed areas, commercial season, description and... have to be in place for an entire harvest/fishing season; (ii) Whether there has been adequate...

  11. Body-Specific Representations of Spatial Location

    ERIC Educational Resources Information Center

    Brunye, Tad T.; Gardony, Aaron; Mahoney, Caroline R.; Taylor, Holly A.

    2012-01-01

    The body specificity hypothesis (Casasanto, 2009) posits that the way in which people interact with the world affects their mental representation of information. For instance, right- versus left-handedness affects the mental representation of affective valence, with right-handers categorically associating good with rightward areas and bad with…

  12. 24 CFR 16.15 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Specific exemptions. 16.15 Section 16.15 Housing and Urban Development Office of the Secretary, Department of Housing and Urban... Housing and Urban Development determines it to be necessary and proper, with respect to any system...

  13. 24 CFR 16.15 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Specific exemptions. 16.15 Section 16.15 Housing and Urban Development Office of the Secretary, Department of Housing and Urban... Housing and Urban Development determines it to be necessary and proper, with respect to any system...

  14. 24 CFR 2003.9 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 5 2014-04-01 2014-04-01 false Specific exemptions. 2003.9 Section 2003.9 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF INSPECTOR GENERAL, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT IMPLEMENTATION OF THE...

  15. 24 CFR 2003.9 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 5 2013-04-01 2013-04-01 false Specific exemptions. 2003.9 Section 2003.9 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF INSPECTOR GENERAL, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT IMPLEMENTATION OF THE...

  16. 24 CFR 2003.9 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 5 2012-04-01 2012-04-01 false Specific exemptions. 2003.9 Section 2003.9 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF INSPECTOR GENERAL, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT IMPLEMENTATION OF THE...

  17. 24 CFR 16.15 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Specific exemptions. 16.15 Section 16.15 Housing and Urban Development Office of the Secretary, Department of Housing and Urban... Housing and Urban Development determines it to be necessary and proper, with respect to any system...

  18. Video in English for Specific Purposes.

    ERIC Educational Resources Information Center

    Hristova, Rozinka

    For an English for Specific Purposes (ESP) course to be efficient, the learner and his/her communicative needs should be central in deciding course content and activities. Video can be highly motivating by presenting live instances of communication in the target environment. It is a valuable medium for intensive analysis of visual and nonverbal…

  19. 46 CFR 172.047 - Specific applicability.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Specific applicability. 172.047 Section 172.047 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO BULK CARGOES Special Rules Pertaining to a Barge That Carries a Cargo Regulated Under Subchapter D of This Chapter § 172.047...

  20. 46 CFR 172.047 - Specific applicability.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Specific applicability. 172.047 Section 172.047 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO BULK CARGOES Special Rules Pertaining to a Barge That Carries a Cargo Regulated Under Subchapter D of This Chapter § 172.047...

  1. 10 CFR 50.36 - Technical specifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... nuclear reactors are limits upon important process variables that are found to be necessary to reasonably... process variables must be maintained for adequate control of the operation and that must not be exceeded..., corrective action must be taken as stated in the technical specification or the affected part of the...

  2. Encoding Specificity for Sentences in Connected Discourse.

    ERIC Educational Resources Information Center

    Christiaansen, Robert E.; Dooling, D. James

    The encoding specificity principle predicts that a change in context between input and test will adversely affect recognition memory. Experiment I tested this with sentences from a prose passage and no context effects were obtained. Experiments II, III, and IV compared context effects for words in random sentences versus connected discourse. In…

  3. 21 CFR 1270.35 - Specific records.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Specific records. 1270.35 Section 1270.35 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) REGULATIONS UNDER CERTAIN OTHER ACTS ADMINISTERED BY THE FOOD AND DRUG ADMINISTRATION HUMAN TISSUE INTENDED...

  4. Specification of the Model 3 General Lexicon.

    ERIC Educational Resources Information Center

    Rhode, Mary

    The Model 3 communication skills lexicon consists of three lists of words developed by the Southwest Regional Laboratory (SWRL) for use in communication skills instruction in K-6. This report documents the procedures followed in the specification and generation of the second component of the Model 3 communication skills lexicon, the general…

  5. Specific Learning Disability, 1982-83 Study.

    ERIC Educational Resources Information Center

    Enell, Nancy C.; Lee, Peter

    During the spring of 1981, a San Juan Task force of special education staff members developed revised criteria for the identification of students with specific learning disabilities (SLD). This report covers the second year of discrepancy criteria implementation. It examines the identification of 225 students with SLD during the first semester of…

  6. 10 CFR 54.15 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Specific exemptions. 54.15 Section 54.15 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) REQUIREMENTS FOR RENEWAL OF OPERATING LICENSES FOR NUCLEAR POWER PLANTS... granted by the Commission in accordance with 10 CFR 50.12....

  7. 31 CFR 586.315 - Specific license.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Specific license. 586.315 Section 586.315 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY FEDERAL REPUBLIC OF YUGOSLAVIA (SERBIA &...

  8. Patient-Specific Models of Cardiac Biomechanics.

    PubMed

    Krishnamurthy, Adarsh; Villongco, Christopher T; Chuang, Joyce; Frank, Lawrence R; Nigam, Vishal; Belezzuoli, Ernest; Stark, Paul; Krummen, David E; Narayan, Sanjiv; Omens, Jeffrey H; McCulloch, Andrew D; Kerckhoffs, Roy Cp

    2013-07-01

    Patient-specific models of cardiac function have the potential to improve diagnosis and management of heart disease by integrating medical images with heterogeneous clinical measurements subject to constraints imposed by physical first principles and prior experimental knowledge. We describe new methods for creating three-dimensional patient-specific models of ventricular biomechanics in the failing heart. Three-dimensional bi-ventricular geometry is segmented from cardiac CT images at end-diastole from patients with heart failure. Human myofiber and sheet architecture is modeled using eigenvectors computed from diffusion tensor MR images from an isolated, fixed human organ-donor heart and transformed to the patient-specific geometric model using large deformation diffeomorphic mapping. Semi-automated methods were developed for optimizing the passive material properties while simultaneously computing the unloaded reference geometry of the ventricles for stress analysis. Material properties of active cardiac muscle contraction were optimized to match ventricular pressures measured by cardiac catheterization, and parameters of a lumped-parameter closed-loop model of the circulation were estimated with a circulatory adaptation algorithm making use of information derived from echocardiography. These components were then integrated to create a multi-scale model of the patient-specific heart. These methods were tested in five heart failure patients from the San Diego Veteran's Affairs Medical Center who gave informed consent. The simulation results showed good agreement with measured echocardiographic and global functional parameters such as ejection fraction and peak cavity pressures. PMID:23729839

  9. 50 CFR 648.260 - Specifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Specifications. 648.260 Section 648.260 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE FISHERIES OF THE NORTHEASTERN UNITED STATES Management Measures for the Atlantic...

  10. 50 CFR 648.260 - Specifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Specifications. 648.260 Section 648.260 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE FISHERIES OF THE NORTHEASTERN UNITED STATES Management Measures for the Atlantic...

  11. 50 CFR 648.260 - Specifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Specifications. 648.260 Section 648.260 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE FISHERIES OF THE NORTHEASTERN UNITED STATES Management Measures for the Atlantic...

  12. 50 CFR 648.260 - Specifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Specifications. 648.260 Section 648.260 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE FISHERIES OF THE NORTHEASTERN UNITED STATES Management Measures for the Atlantic...

  13. Estimating Genotype- and Environment-Specific Heritabilities

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The advantages of computing genotype- and environment-specific heritabilities are discussed. A statistical approach is used in which logvariances of both genotype by environment interaction and error are modeled as random variables. Resulting estimators of variances are weighted averages of a pool...

  14. 50 CFR 648.162 - Bluefish specifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Bluefish specifications. 648.162 Section 648.162 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE FISHERIES OF THE NORTHEASTERN UNITED STATES Management Measures for the Atlantic Bluefish Fishery §...

  15. 50 CFR 660.508 - Annual specifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Annual specifications. 660.508 Section 660.508 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... closure of the directed fishery; (3) The estimated level of the incidental trip limit that will be...

  16. 50 CFR 660.508 - Annual specifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Annual specifications. 660.508 Section 660.508 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... closure of the directed fishery; (3) The estimated level of the incidental trip limit that will be...

  17. 50 CFR 660.508 - Annual specifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Annual specifications. 660.508 Section 660.508 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... harvests after closure of the directed fishery; (4) The estimated level of the incidental trip limit...

  18. 50 CFR 660.508 - Annual specifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Annual specifications. 660.508 Section 660.508 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... harvests after closure of the directed fishery; (4) The estimated level of the incidental trip limit...

  19. Item-Specific Gender Differences in Confidence.

    ERIC Educational Resources Information Center

    Foote, Chandra J.

    Very little research has been performed which examines gender differences in confidence in highly specified situations. More generalized studies consistently suggest that women are less confident than men (i.e. Sadker and Sadker, 1994). The few studies of gender differences in item-specific conditions indicate that men tend to be more confident in…

  20. 50 CFR 648.41 - Framework specifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Atlantic Salmon § 648.41 Framework specifications. (a) Within season management action. The New England... Atlantic salmon management measures to allow for Atlantic salmon aquaculture projects in the EEZ, provided such an action is consistent with the goals and objectives of the Atlantic Salmon FMP. (b)...

  1. 50 CFR 648.41 - Framework specifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Atlantic Salmon § 648.41 Framework specifications. (a) Within season management action. The New England... Atlantic salmon management measures to allow for Atlantic salmon aquaculture projects in the EEZ, provided such an action is consistent with the goals and objectives of the Atlantic Salmon FMP. (b)...

  2. 50 CFR 648.41 - Framework specifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Atlantic Salmon § 648.41 Framework specifications. (a) Within season management action. The New England... Atlantic salmon management measures to allow for Atlantic salmon aquaculture projects in the EEZ, provided such an action is consistent with the goals and objectives of the Atlantic Salmon FMP. (b)...

  3. 50 CFR 648.41 - Framework specifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Atlantic Salmon § 648.41 Framework specifications. (a) Within season management action. The New England... Atlantic salmon management measures to allow for Atlantic salmon aquaculture projects in the EEZ, provided such an action is consistent with the goals and objectives of the Atlantic Salmon FMP. (b)...

  4. 50 CFR 648.41 - Framework specifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Atlantic Salmon § 648.41 Framework specifications. (a) Within season management action. The New England... Atlantic salmon management measures to allow for Atlantic salmon aquaculture projects in the EEZ, provided such an action is consistent with the goals and objectives of the Atlantic Salmon FMP. (b)...

  5. English for Specific Purposes. Information Guide 2.

    ERIC Educational Resources Information Center

    British Council, London (England). English-Teaching Information Centre.

    This bibliography of materials for teachers of English for specific purposes lists textbooks, technical readers, articles, resource books, reports, dictionaries, reference books, bibliographies, word frequency lists, catalogues of teaching aids, games and activities, current research in Britain, documents available in the archives of the English…

  6. Ribosomopathies: Global process, tissue specific defects.

    PubMed

    Yelick, Pamela C; Trainor, Paul A

    2015-01-01

    Disruptions in ribosomal biogenesis would be expected to have global and in fact lethal effects on a developing organism. However, mutations in ribosomal protein genes have been shown in to exhibit tissue specific defects. This seemingly contradictory finding - that globally expressed genes thought to play fundamental housekeeping functions can in fact exhibit tissue and cell type specific functions - provides new insight into roles for ribosomes, the protein translational machinery of the cell, in regulating normal development and disease. Furthermore it illustrates the surprisingly dynamic nature of processes regulating cell type specific protein translation. In this review, we discuss our current knowledge of a variety of ribosomal protein mutations associated with human disease, and models to better understand the molecular mechanisms associated with each. We use specific examples to emphasize both the similarities and differences between the effects of various human ribosomal protein mutations. Finally, we discuss areas of future study that are needed to further our understanding of the role of ribosome biogenesis in normal development, and possible approaches that can be used to treat debilitating ribosomopathy diseases. PMID:26442198

  7. Ribosomopathies: Global process, tissue specific defects

    PubMed Central

    Yelick, Pamela C; Trainor, Paul A

    2015-01-01

    Disruptions in ribosomal biogenesis would be expected to have global and in fact lethal effects on a developing organism. However, mutations in ribosomal protein genes have been shown in to exhibit tissue specific defects. This seemingly contradictory finding - that globally expressed genes thought to play fundamental housekeeping functions can in fact exhibit tissue and cell type specific functions ‐ provides new insight into roles for ribosomes, the protein translational machinery of the cell, in regulating normal development and disease. Furthermore it illustrates the surprisingly dynamic nature of processes regulating cell type specific protein translation. In this review, we discuss our current knowledge of a variety of ribosomal protein mutations associated with human disease, and models to better understand the molecular mechanisms associated with each. We use specific examples to emphasize both the similarities and differences between the effects of various human ribosomal protein mutations. Finally, we discuss areas of future study that are needed to further our understanding of the role of ribosome biogenesis in normal development, and possible approaches that can be used to treat debilitating ribosomopathy diseases. PMID:26442198

  8. 24 CFR 16.15 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Specific exemptions. 16.15 Section 16.15 Housing and Urban Development Office of the Secretary, Department of Housing and Urban... Housing and Urban Development determines it to be necessary and proper, with respect to any system...

  9. 24 CFR 16.15 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Specific exemptions. 16.15 Section 16.15 Housing and Urban Development Office of the Secretary, Department of Housing and Urban... Housing and Urban Development determines it to be necessary and proper, with respect to any system...

  10. 24 CFR 2003.9 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 5 2011-04-01 2011-04-01 false Specific exemptions. 2003.9 Section 2003.9 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF INSPECTOR GENERAL, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT IMPLEMENTATION OF THE...

  11. 24 CFR 2003.9 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Specific exemptions. 2003.9 Section 2003.9 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF INSPECTOR GENERAL, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT IMPLEMENTATION OF THE...

  12. 16 CFR 1209.35 - Product specification.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION Certification § 1209.35 Product specification. (a... insulation which is subject to the standard, it shall ensure that the insulation is described in a written... following information: (1) A description of the equipment used to manufacture the insulation, including...

  13. 16 CFR 1209.35 - Product specification.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION Certification § 1209.35 Product specification. (a... insulation which is subject to the standard, it shall ensure that the insulation is described in a written... following information: (1) A description of the equipment used to manufacture the insulation, including...

  14. 16 CFR 1209.35 - Product specification.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION Certification § 1209.35 Product specification. (a... insulation which is subject to the standard, it shall ensure that the insulation is described in a written... following information: (1) A description of the equipment used to manufacture the insulation, including...

  15. Evolution of immune systems: specificity and autoreactivity.

    PubMed

    Bailey, Mick; Christoforidou, Zoe; Lewis, Marie

    2013-04-01

    Multicellularity evolved well before 600 million years ago, and all multicellular animals have evolved since then with the need to protect against pathogens. There is no reason to expect their immune systems to be any less sophisticated than ours. The vertebrate system, based on rearranging immunoglobulin-superfamily domains, appears to have evolved partly as a result of chance insertion of RAG genes by horizontal transfer. Remarkably sophisticated systems for expansion of immunological repertoire have evolved in parallel in many groups of organisms. Vaccination of invertebrates against commercially important pathogens has been empirically successful, and suggests that the definition of an adaptive and innate immune system should no longer depend on the presence of memory and specificity, since these terms are hard to define in themselves. The evolution of randomly-created immunological repertoire also carries with it the potential for generating autoreactive specificities and consequent autoimmune damage. While invertebrates may use systems analogous to ours to control autoreactive specificities, they may have evolved alternative mechanisms which operate either at the level of individuals-within-populations rather than cells-within-individuals, by linking self-reactive specificities to regulatory pathways and non-self-reactive to effector pathways. PMID:23201916

  16. Public Address Systems. Specifications - Installation - Operation.

    ERIC Educational Resources Information Center

    Palmer, Fred M.

    Provisions for public address in new construction of campus buildings (specifications, installations, and operation of public address systems), are discussed in non-technical terms. Consideration is given to microphones, amplifiers, loudspeakers and the placement and operation of various different combinations. (FS)

  17. Standard specification for cadmium. ASTM standard

    SciTech Connect

    1998-09-01

    This specification is under the jurisdiction of ASTM Committee B-2 on Nonferrous Metals and Alloys and is the direct responsibility of Subcommittee B02.04 on Zinc and Cadmium. Current edition approved Apr. 10, 1998 and published September 1998. Originally published as B 440-66T. Last previous edition was B 440-76.

  18. 10 CFR 72.7 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Specific exemptions. 72.7 Section 72.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE General Provisions §...

  19. 10 CFR 72.7 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Specific exemptions. 72.7 Section 72.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE General Provisions §...

  20. 10 CFR 72.7 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Specific exemptions. 72.7 Section 72.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE General Provisions §...

  1. 10 CFR 72.7 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Specific exemptions. 72.7 Section 72.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE General Provisions §...

  2. 10 CFR 72.7 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Specific exemptions. 72.7 Section 72.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE General Provisions §...

  3. Sense and specificity in neuronal calcium signalling☆

    PubMed Central

    Burgoyne, Robert D.; Haynes, Lee P.

    2015-01-01

    Changes in the intracellular free calcium concentration ([Ca2 +]i) in neurons regulate many and varied aspects of neuronal function over time scales from microseconds to days. The mystery is how a single signalling ion can lead to such diverse and specific changes in cell function. This is partly due to aspects of the Ca2 + signal itself, including its magnitude, duration, localisation and persistent or oscillatory nature. The transduction of the Ca2 + signal requires Ca2 + binding to various Ca2 + sensor proteins. The different properties of these sensors are important for differential signal processing and determine the physiological specificity of Ca2 + signalling pathways. A major factor underlying the specific roles of particular Ca2 + sensor proteins is the nature of their interaction with target proteins and how this mediates unique patterns of regulation. We review here recent progress from structural analyses and from functional analyses in model organisms that have begun to reveal the rules that underlie Ca2 + sensor protein specificity for target interaction. We discuss three case studies exemplifying different aspects of Ca2 + sensor/target interaction. This article is part of a special issue titled the 13th European Symposium on Calcium. PMID:25447549

  4. System specification for the reusable reentry satellite

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The RRS design shall provide a relatively inexpensive method of access to micro and fractional gravity space environments for an extended period of time, with eventual intact recovery on the surface of the Earth. This specification establishes the performance, design, development, and test requirements for the Reusable Reentry Satellite (RRS) system.

  5. The Specific Analysis of Structural Equation Models

    ERIC Educational Resources Information Center

    McDonald, Roderick P.

    2004-01-01

    Conventional structural equation modeling fits a covariance structure implied by the equations of the model. This treatment of the model often gives misleading results because overall goodness of fit tests do not focus on the specific constraints implied by the model. An alternative treatment arising from Pearl's directed acyclic graph theory…

  6. 29 CFR 1918.52 - Specific requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR LONGSHORING Vessel's Cargo Handling Gear § 1918.52 Specific... tails, fittings, or other means of making the preventers fast on the deck shall provide strength...

  7. 29 CFR 1918.52 - Specific requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR LONGSHORING Vessel's Cargo Handling Gear § 1918.52 Specific... tails, fittings, or other means of making the preventers fast on the deck shall provide strength...

  8. 29 CFR 1918.52 - Specific requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR LONGSHORING Vessel's Cargo Handling Gear § 1918.52 Specific... tails, fittings, or other means of making the preventers fast on the deck shall provide strength...

  9. 29 CFR 1918.52 - Specific requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR LONGSHORING Vessel's Cargo Handling Gear § 1918.52 Specific... tails, fittings, or other means of making the preventers fast on the deck shall provide strength...

  10. Evaluation of the Learning Path Specification

    ERIC Educational Resources Information Center

    Janssen, Jose; Berlanga, Adriana J.; Koper, Rob

    2011-01-01

    Flexible lifelong learning requires that learners can compare and select learning paths that best meet individual needs, not just in terms of learning goals, but also in terms of planning, costs etc. To this end a learning path specification was developed, which describes both the contents and the structure of any learning path, be it formal,…

  11. Non-Specific Immunotherapies and Adjuvants

    MedlinePlus

    ... and spinal cord. Other drugs that boost the immune system Some other drugs boost the immune system in a non-specific way, similar to cytokines. ... and CTLA-4, which normally help keep the immune system in check. While these checkpoint proteins are important ...

  12. Improved specificity of hippocampal memory trace labeling.

    PubMed

    Cazzulino, Alejandro S; Martinez, Randy; Tomm, Nicole K; Denny, Christine A

    2016-06-01

    Recent studies have focused on the identification and manipulation of memory traces in rodent models. The two main mouse models utilized are either a CreER(T2) /loxP tamoxifen (TAM)- or a tetracycline transactivator/tetracycline-response element doxycycline-inducible system. These systems, however, could be improved to label a more specific population of activated neurons corresponding to behavior. Here, we sought to identify an improved selective estrogen receptor (ER) modulator (SERM) in which we could label an individual memory trace in ArcCreER(T2) mice. We found that 4-hydroxytamoxifen (4-OHT) is a selective SERM in the ArcCreER(T2) × Rosa26-CAG-stop(flox) -channelrhodospin (ChR2)-enhanced yellow fluorescent protein (eYFP) mice. The half-life of 4-OHT is shorter than TAM, allowing for more specificity of memory trace labeling. Furthermore, 4-OHT allowed for context-specific labeling in the dentate gyrus and CA3. In summary, we believe that 4-OHT improves the specificity of memory trace labeling and will allow for refined memory trace studies in the future. © 2015 Wiley Periodicals, Inc. PMID:26662713

  13. Copper coating specification for the RHIC arcs

    SciTech Connect

    Blaskiewicz, M.

    2010-12-01

    Copper coating specifications for the RHIC arcs are given. Various upgrade scenarios are considered and calculations of resistive wall losses in the arcs are used to constrain the necessary quality and surface thickness of a copper coating. We find that 10 {mu}m of high purity copper will suffice.

  14. Composing a Tumor Specific Bacterial Promoter

    PubMed Central

    Deyneko, Igor V.; Kasnitz, Nadine; Leschner, Sara; Weiss, Siegfried

    2016-01-01

    Systemically applied Salmonella enterica spp. have been shown to invade and colonize neoplastic tissues where it retards the growth of many tumors. This offers the possibility to use the bacteria as a vehicle for the tumor specific delivery of therapeutic molecules. Specificity of such delivery is solely depending on promoter sequences that control the production of a target molecule. We have established the functional structure of bacterial promoters that are transcriptionally active exclusively in tumor tissues after systemic application. We observed that the specific transcriptional activation is accomplished by a combination of a weak basal promoter and a strong FNR binding site. This represents a minimal set of control elements required for such activation. In natural promoters, additional DNA remodeling elements are found that alter the level of transcription quantitatively. Inefficiency of the basal promoter ensures the absence of transcription outside tumors. As a proof of concept, we compiled an artificial promoter sequence from individual motifs representing FNR and basal promoter and showed specific activation in a tumor microenvironment. Our results open possibilities for the generation of promoters with an adjusted level of expression of target proteins in particular for applications in bacterial tumor therapy. PMID:27171245

  15. Specificity of aequorin luminescence to calcium

    NASA Technical Reports Server (NTRS)

    Shimomura, O.; Johnson, F. H.

    1975-01-01

    The presence of Pb(++), Co(++), Cu(++), and Cd(++), each of which possesses a certain luminescence-triggering activity of aequorin, potentially interferes with the specificity of the aequorin luminescence response to Ca(++). Interference by the above cations can be eliminated, without influencing the sensitivity of the luminescence of aequorin to Ca(++), by adding 1 mM of sodium diethyldithiocarbamate.

  16. 50 CFR 648.200 - Specifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Specifications. 648.200 Section 648.200 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE FISHERIES OF THE NORTHEASTERN UNITED STATES Management Measures for the Atlantic Herring Fishery §...

  17. Development of the Specific Adaptation Mobility Cane.

    ERIC Educational Resources Information Center

    Arrington, S.

    1995-01-01

    A travel cane was adapted for use by a 10-year-old boy with cortical blindness, severe mental retardation and cerebral palsy affecting his left arm and leg. The Specific Adaptation Mobility Cane utilizes the affected arm to hold the cane while leaving the other hand free for trailing walls, opening doors, carrying objects, and holding handrails.…

  18. 32 CFR 1901.63 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 6 2012-07-01 2012-07-01 false Specific exemptions. 1901.63 Section 1901.63 National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY PUBLIC RIGHTS... section (k) of the Privacy Act, the Director of Central Intelligence has determined to exempt from...

  19. 32 CFR 1901.63 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 6 2014-07-01 2014-07-01 false Specific exemptions. 1901.63 Section 1901.63 National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY PUBLIC RIGHTS... section (k) of the Privacy Act, the Director of Central Intelligence has determined to exempt from...

  20. ORGAN AND SPECIES SPECIFICITY IN CHEMICAL CARCINOGENESIS

    EPA Science Inventory

    The focus of the Symposium and this volume is the relative susceptibility of specific animal species strains and organs to various carcinogens. For the first time, investigators in chemical carcinogenesis are able to pool their discoveries in this area. Once analyzed, this data c...

  1. Measuring Language-Specific Phonetic Settings

    ERIC Educational Resources Information Center

    Mennen, Ineke; Scobbie, James M.; de Leeuw, Esther; Schaeffler, Sonja; Schaeffler, Felix

    2010-01-01

    While it is well known that languages have different phonemes and phonologies, there is growing interest in the idea that languages may also differ in their "phonetic setting". The term "phonetic setting" refers to a tendency to make the vocal apparatus employ a language-specific habitual configuration. For example, languages may differ in their…

  2. 31 CFR 597.315 - Specific license.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Specific license. 597.315 Section 597.315 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY FOREIGN TERRORIST ORGANIZATIONS SANCTIONS...

  3. 31 CFR 597.315 - Specific license.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Specific license. 597.315 Section 597.315 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY FOREIGN TERRORIST ORGANIZATIONS SANCTIONS...

  4. 31 CFR 597.315 - Specific license.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Specific license. 597.315 Section 597.315 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY FOREIGN TERRORIST ORGANIZATIONS SANCTIONS...

  5. 31 CFR 597.315 - Specific license.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Specific license. 597.315 Section 597.315 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY FOREIGN TERRORIST ORGANIZATIONS SANCTIONS...

  6. 31 CFR 597.315 - Specific license.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Specific license. 597.315 Section 597.315 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY FOREIGN TERRORIST ORGANIZATIONS SANCTIONS...

  7. Site Specific Evaluation of Multisensor Capacitance Probes

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Multisensor capacitance probes (MCPs) are widely used for measuring soil water content (SWC) at the field scale. Although manufacturers supply a generic MCP calibration, many researchers recognize that MCPs should be calibrated for specific field conditions. MCPs measurements are typically associa...

  8. Seeking a Principalship: Specific Position Attractors

    ERIC Educational Resources Information Center

    Walker, Allan; Kwan, Paula

    2009-01-01

    Purpose: This article reports on a study designed to uncover the factors aspiring secondary school principals consider important when deciding whether to apply for a specific post. The aspiring principals involved in the study had all confirmed their desire to be a principal; about half were already vice-principals. Methods: Evidence for the study…

  9. 7 CFR 57.100 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Specific exemptions. 57.100 Section 57.100 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946...

  10. Enzyme Specific Activity in Functionalized Nanoporous Supports

    SciTech Connect

    Lei, Chenghong; Soares, Thereza A.; Shin, Yongsoon; Liu, Jun; Ackerman, Eric J.

    2008-03-26

    Enzyme specific activity can be increased or decreased to a large extent by changing protein loading density in functionalized nanoporous support, where organophosphorus hydrolase can display a constructive orientation and thus leave a completely open entrance for substrate even at higher protein loading density, but glucose oxidase can not.

  11. 37 CFR 102.34 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .../DEPT-14; (D) Attorneys and Agents Registered to Practice Before the Office—COMMERCE/PAT-TM-1; (E... OF COMMERCE ADMINISTRATION DISCLOSURE OF GOVERNMENT INFORMATION Privacy Act § 102.34 Specific... are within this exemption are: COMMERCE/PAT-TM-6, COMMERCE/PAT-TM-7, COMMERCE/PAT-TM-8,...

  12. Ultrasonic hydrometer. [Specific gravity of electrolyte

    DOEpatents

    Swoboda, C.A.

    1982-03-09

    The disclosed ultrasonic hydrometer determines the specific gravity (density) of the electrolyte of a wet battery, such as a lead-acid battery. The hydrometer utilizes a transducer that when excited emits an ultrasonic impulse that traverses through the electrolyte back and forth between spaced sonic surfaces. The transducer detects the returning impulse, and means measures the time t between the initial and returning impulses. Considering the distance d between the spaced sonic surfaces and the measured time t, the sonic velocity V is calculated with the equation V = 2d/t. The hydrometer also utilizes a thermocouple to measure the electrolyte temperature. A hydrometer database correlates three variable parameters including sonic velocity in and temperature and specific gravity of the electrolyte, for temperature values between 0 and 40/sup 0/C and for specific gravity values between 1.05 and 1.30. Upon knowing two parameters (the calculated sonic velocity and the measured temperature), the third parameter (specific gravity) can be uniquely found in the database. The hydrometer utilizes a microprocessor for data storage and manipulation.

  13. Model Educational Specifications for Technology in Schools.

    ERIC Educational Resources Information Center

    Maryland State Dept. of Education, College Park. Office of Administration and Finance.

    This description of the Model Edspec, which can be used by itself or in conjunction with the "Format Guide of Educational Specifications," serves as a comprehensive planning tool for the selection and application of technology. The model is designed to assist schools in implementing the facilities development process, thereby making electronic…

  14. 32 CFR 319.13 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROGRAM DEFENSE INTELLIGENCE AGENCY PRIVACY PROGRAM § 319.13 Specific exemptions. (a) All systems of records maintained by the Director Intelligence Agency shall be exempt from the requirements of 5 U.S.C... has been properly classified. (b) The Director, Defense Intelligence Agency, designated the systems...

  15. 32 CFR 1901.63 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Specific exemptions. 1901.63 Section 1901.63 National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY PUBLIC RIGHTS... section (k) of the Privacy Act, the Director of Central Intelligence has determined to exempt from...

  16. 32 CFR 319.13 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... PROGRAM DEFENSE INTELLIGENCE AGENCY PRIVACY PROGRAM § 319.13 Specific exemptions. (a) All systems of records maintained by the Director Intelligence Agency shall be exempt from the requirements of 5 U.S.C... has been properly classified. (b) The Director, Defense Intelligence Agency, designated the systems...

  17. 32 CFR 1901.63 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Specific exemptions. 1901.63 Section 1901.63 National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY PUBLIC RIGHTS... section (k) of the Privacy Act, the Director of Central Intelligence has determined to exempt from...

  18. 32 CFR 319.13 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PROGRAM DEFENSE INTELLIGENCE AGENCY PRIVACY PROGRAM § 319.13 Specific exemptions. (a) All systems of records maintained by the Director Intelligence Agency shall be exempt from the requirements of 5 U.S.C... has been properly classified. (b) The Director, Defense Intelligence Agency, designated the systems...

  19. Teacher's Corner: Conducting Specification Searches with Amos

    ERIC Educational Resources Information Center

    Schumacker, Randall E.

    2006-01-01

    Amos 5.0 (Arbuckle, 2003) permits exploratory specification searches for the best theoretical model given an initial model using the following fit function criteria: chi-square (C), chi-square--df (C--df), Akaike Information Criteria (AIC), Browne-Cudeck criterion (BCC), Bayes Information Criterion (BIC) , chi-square divided by the degrees of…

  20. Side-Specific Reward Memories in Honeybees

    ERIC Educational Resources Information Center

    Gil, Mariana; Menzel, Randolf; De Marco, Rodrigo J.

    2009-01-01

    We report a hitherto unknown form of side-specific learning in honeybees. We trained bees individually by coupling gustatory and mechanical stimulation of each antenna with either increasing or decreasing volumes of sucrose solution offered to the animal's proboscis along successive learning trials. Next, we examined their proboscis extension…