Science.gov

Sample records for abbe sine condition

  1. Abbe, Ernst (1840-1905)

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    Born in Eisenach, Grand Duchy of Saxe-Weimar-Eisenach (now Germany), Abbe became director of the observatory at Jena and research director of the CARL ZEISS optical works in Jena. He discovered the Abbe sine condition, which describes a lens that will form an image, without defects of coma and spherical aberration. His mathematical treatment founded the present-day science of optics....

  2. A generalized sine condition and performance comparison of Wolter type II and Wolter-Schwarzschild extreme ultraviolet telescopes

    NASA Astrophysics Data System (ADS)

    Saha, T. T.

    1984-01-01

    An equation similar to the Abbe sine condition is derived for a Wolter type II telescope. This equation and the sine condition are then combined to produce a so called generalized sine condition. Using the law of reflection, Fermat's principle, the generalized sine condition, and simple geometry the surface equations for a Wolter type II telescope and an equivalent Wolter-Schwarzschild telescope are calculated. The performances of the telescopes are compared in terms of rms blur circle radius at the gaussian focal plane and at best focus.

  3. New formulations between spherical aberration and spherical aberration coefficient using the Abbe sine condition

    NASA Astrophysics Data System (ADS)

    Kang, Songgao; Lu, Kaichang; Zhu, Yafei

    1991-12-01

    The relationship between aberration and the aberration coefficient is the basic formulation in the field of aberration theory. The Seidel's formulations can only be used in the case of low performance (small aperture and small field), so that a set of correct relations between spherical aberration (SA) and spherical aberration coefficient (SAC) must be derived for the application of large aperture and small viewing field.

  4. Breaking integrability at the boundary: the sine-Gordon model with Robin boundary conditions

    NASA Astrophysics Data System (ADS)

    Arthur, Robert; Dorey, Patrick; Parini, Robert

    2016-04-01

    We explore boundary scattering in the sine-Gordon model with a non-integrable family of Robin boundary conditions. The soliton content of the field after collision is analysed using a numerical implementation of the direct scattering problem associated with the inverse scattering method. We find that an antikink may be reflected into various combinations of an antikink, a kink, and one or more breathers, depending on the values of the initial antikink velocity and a parameter associated with the boundary condition. In addition we observe regions with an intricate resonance structure arising from the creation of an intermediate breather whose recollision with the boundary is highly dependent on the breather phase.

  5. EMERGING TECHNOLOGY BULLETIN: TWO-ZONE PCE BIOREMEDIATION SYSTEM - ABB ENVIRONMENTAL SERVICES, INC. - U.S. ENVIRONMENTAL PROTECTION AGENCY

    EPA Science Inventory

    ABB Environmental Services, Inc.'s (ABB-ES), research has demonstrated that sequential anaerobic/aerobic biodegradation of tetrachloroethylene (PCE) is feasible if the proper conditions can be established. The anaerobic process can potentially completely dechlorinate PCE. Howeve...

  6. ABB Combustion Engineering nuclear technology

    SciTech Connect

    Matzie, R.A.

    1994-12-31

    The activities of ABB Combustion Engineering in the design and construction of nuclear systems and components are briefly reviewed. ABB Construction Engineering continues to improve the design and design process for nuclear generating stations. Potential improvements are evaluated to meet new requirements both of the public and the regulator, so that the designs meet the highest standards worldwide. Advancements necessary to meet market needs and to ensure the highest level of performance in the future will be made.

  7. ABB: active bandwidth broker

    NASA Astrophysics Data System (ADS)

    Wong, Kason; Law, Eddie

    2001-07-01

    In this paper, we shall discuss a novel design on the policy-based management for the Internet. This design deploys the concept of active networking. As opposed to the traditional network design, active network empowers network node with the ability to manipulate data and program code in packets, and configure the network properties according to the needs of different applications. The policy-based management can control network routers in order to realize end-to-end Quality of Service (QoS), such as differentiated and integrated services, across the Internet. For the moment, the Internet Engineering Task Force (IETF) has defined the framework of the policy-based management. It employs a simple client/server model that uses Common Open Policy Service (COPS) protocol to facilitate policy management and control. Our design of Active Bandwidth Broker (ABB) belongs to an active application. Our goals are to distribute centralized workload of the policy-based management over multiple active nodes in the active networks, introduce mobility of the bandwidth brokers, and allows load sharing to the policy-based management. This results a network-wide intelligent, highly available, and consistent QoS control that allows performance protection for voice, video and Internet business application while reducing costs for growing networks.

  8. Korean order latest ABB project in Asia

    SciTech Connect

    1996-07-01

    ABB, in various incarnations, has been active in Asia from the beginning of the century. The new power plant in Korea represents a major commitment on the part of Korea Electric Power Corporation to ABB`s newest technology - the advanced sequential combustion gas turbine. For installation in Poryong, Korea, KEPCO has ordered a 2000MW combined-cycle power plant based on eight of ABB`s new GT24 gas turbines. This paper describes the project and specifications.

  9. ABB and the global market

    SciTech Connect

    Lindahl, G. )

    1994-09-01

    Competing in a global environment implies that the authors previous business environment has been less than global, and there are indeed changes underway that lead to a more universal environment. But, there are still differences between regions and especially between the mature economies in the OECD countries and the rapidly developing countries, of which a majority are in Asia. For the OECD countries, the time after World War 2 and up to about 1970 was a period of unprecedented growth. Rebuilding after the war and a general growth of the use of electric power required high investments in power systems and caused a booming market for equipment suppliers. After a trend break in the beginning of the 1970s to less than 40 GW 10 years later, then slowly increased to about 50 GW today. At the same time, annual capacity growth in developing countries increased from less than 20 GW to about 50 GW, i.e. the same level as in OECD. This means that ABB is now passing a cross-over point: from now on less than half of their global market is in their well-known OECD world. And this share will continue to shrink. ABB is now restructuring to fulfill market needs in less developed, developing, and newly industrialized countries. This is the most important change in their global environment is addressed in this article.

  10. Genetic code for sine

    NASA Astrophysics Data System (ADS)

    Abdullah, Alyasa Gan; Wah, Yap Bee

    2015-02-01

    The computation of the approximate values of the trigonometric sines was discovered by Bhaskara I (c. 600-c.680), a seventh century Indian mathematician and is known as the Bjaskara's I's sine approximation formula. The formula is given in his treatise titled Mahabhaskariya. In the 14th century, Madhava of Sangamagrama, a Kerala mathematician astronomer constructed the table of trigonometric sines of various angles. Madhava's table gives the measure of angles in arcminutes, arcseconds and sixtieths of an arcsecond. The search for more accurate formulas led to the discovery of the power series expansion by Madhava of Sangamagrama (c.1350-c. 1425), the founder of the Kerala school of astronomy and mathematics. In 1715, the Taylor series was introduced by Brook Taylor an English mathematician. If the Taylor series is centered at zero, it is called a Maclaurin series, named after the Scottish mathematician Colin Maclaurin. Some of the important Maclaurin series expansions include trigonometric functions. This paper introduces the genetic code of the sine of an angle without using power series expansion. The genetic code using square root approach reveals the pattern in the signs (plus, minus) and sequence of numbers in the sine of an angle. The square root approach complements the Pythagoras method, provides a better understanding of calculating an angle and will be useful for teaching the concepts of angles in trigonometry.

  11. 76 FR 8785 - ABB Inc.; License Amendment Request for Decommissioning of the ABB Inc., Combustion Engineering...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-15

    ... NRC E-Filing rule (72 FR 49139, August 28, 2007). The E-Filing process requires participants to submit...--Resident Farmer Thorium and Radium. August 2010. ML102310548. 5. ABB, Inc. Decommissioning Plan Revision 2.... ABB, Inc. Derivation of the Site Specific Soil DCGLs, Addendum, Soil DCGLs for thorium and...

  12. MetaSINEs: Broad Distribution of a Novel SINE Superfamily in Animals

    PubMed Central

    Nishihara, Hidenori; Plazzi, Federico; Passamonti, Marco; Okada, Norihiro

    2016-01-01

    SINEs (short interspersed elements) are transposable elements that typically originate independently in each taxonomic clade (order/family). However, some SINE families share a highly similar central sequence and are thus categorized as a SINE superfamily. Although only four SINE superfamilies (CORE-SINEs, V-SINEs, DeuSINEs, and Ceph-SINEs) have been reported so far, it is expected that new SINE superfamilies would be discovered by deep exploration of new SINEs in metazoan genomes. Here we describe 15 SINEs, among which 13 are novel, that have a similar 66-bp central region and therefore constitute a new SINE superfamily, MetaSINEs. MetaSINEs are distributed from fish to cnidarians, suggesting their common evolutionary origin at least 640 Ma. Because the 3′ tails of MetaSINEs are variable, these SINEs most likely survived by changing their partner long interspersed elements for retrotransposition during evolution. Furthermore, we examined the presence of members of other SINE superfamilies in bivalve genomes and characterized eight new SINEs belonging to the CORE-SINEs, V-SINEs, and DeuSINEs, in addition to the MetaSINEs. The broad distribution of bivalve SINEs suggests that at least three SINEs originated in the common ancestor of Bivalvia. Our comparative analysis of the central domains of the SINEs revealed that, in each superfamily, only a restricted region is shared among all of its members. Because the functions of the central domains of the SINE superfamilies remain unknown, such structural information of SINE superfamilies will be useful for future experimental and comparative analyses to reveal why they have been retained in metazoan genomes during evolution. PMID:26872770

  13. Effect of Impact Damage on the Fatigue Response of TiAl Alloy-ABB-2

    NASA Technical Reports Server (NTRS)

    Draper, S. L.; Lerch, B. A.; Pereira, J. M.; Nathal, M. V.; Nazmy, M. Y.; Staubli, M.; Clemens, D. R.

    2001-01-01

    The ability of gamma-TiAl to withstand potential foreign or domestic object damage is a technical risk to the implementation of gamma-TiAl in low pressure turbine (LPT) blade applications. In the present study, the impact resistance of TiAl alloy ABB-2 was determined and compared to the impact resistance of Ti(48)Al(2)Nb(2)Cr. Specimens were impacted with four different impact conditions with impact energies ranging from 0.22 to 6.09 J. After impacting, the impact damage was characterized by crack lengths on both the front and backside of the impact. Due to the flat nature of gamma-TiAl's S-N (stress vs. cycles to failure) curve, step fatigue tests were used to determine the fatigue strength after impacting. Impact damage increased with increasing impact energy and led to a reduction in the fatigue strength of the alloy. For similar crack lengths, the fatigue strength of impacted ABB-2 was similar to the fatigue strength of impacted Ti(48)Al(2)Nb(2)Cr, even though the tensile properties of the two alloys are significantly different. Similar to Ti(48)Al(2)Nb(2)Cr, ABB-2 showed a classical mean stress dependence on fatigue strength. The fatigue strength of impacted ABB-2 could be accurately predicted using a threshold analysis.

  14. Operating experience with ABB Power Plant Laboratories multi-use combustion test facility

    SciTech Connect

    Jukkola, G.; Levasseur, A.; Mylchreest, D.; Turek, D.

    1999-07-01

    Combustion Engineering, Inc.'s ABB Power Plant Laboratories (PPL) has installed a new Multi-Use Combustion Test Facility to support the product development needs for ABB Group's Power Generation Businesses. This facility provides the flexibility to perform testing under fluidized bed combustion, conventional pulverized-coal firing, and gasification firing conditions, thus addressing the requirements for several test facilities. Initial operation of the facility began in late 1997. This paper will focus on the design and application of this Multi-Use Combustion Test Facility for fluidized bed product development. In addition, this paper will present experimental facility results from initial circulating fluidized bed operation, including combustion and environmental performance, heat transfer, and combustor profiles.

  15. Control of antikinks of the Sine Gordon equation

    NASA Astrophysics Data System (ADS)

    Porubov, A. V.; Bondarenkov, R. S.; Fradkov, A. L.; Andrievsky, B. R.

    2016-06-01

    The control of the smoothness of an antikink profile of the Sine Gordon equation is considered. It is shown that variations in the initial conditions give rise to oscillations on the profile of the antikink. The control algorithm based on variation of one of the coefficient of the equation is developed to recover the smooth wave shape and the phase velocity of the antikink.

  16. MyrSINEs: a novel SINE family in the anteater genomes.

    PubMed

    Nishihara, Hidenori; Kuno, Shuichi; Nikaido, Masato; Okada, Norihiro

    2007-10-01

    Recent rapid generation of genomic sequence data has allowed many researchers to perform comparative analyses in various mammalian species. However, characterization of transposable elements, such as short interspersed repetitive elements (SINEs), has not been reported for several mammalian groups. Because SINEs occupy a large portion of the mammalian genome, they are believed to have contributed to the constitution and diversification of the host genomes during evolution. In the present study, we characterized a novel SINE family in the anteater genomes and designated it the MyrSINE family. Typical SINEs consist of a tRNA-related, a tRNA-unrelated and an AT-rich (or poly-A) region. MyrSINEs have only tRNA-related and poly-A regions; they are included in a group called t-SINE. The tRNA-related regions of the MyrSINEs were found to be derived from tRNA(Gly). We demonstrate that the MyrSINE family can be classified into three subfamilies. Two of the MyrSINE subfamilies are distributed in the genomes of both giant anteater and tamandua, while the other is present only in the giant anteater. We discuss the evolutionary history of MyrSINEs and their relationship to the evolution of anteaters. We also speculate that the simple structure of t-SINEs may be a potential evolutionary source for the generation of the typical SINE structure.

  17. MyrSINEs: a novel SINE family in the anteater genomes.

    PubMed

    Nishihara, Hidenori; Kuno, Shuichi; Nikaido, Masato; Okada, Norihiro

    2007-10-01

    Recent rapid generation of genomic sequence data has allowed many researchers to perform comparative analyses in various mammalian species. However, characterization of transposable elements, such as short interspersed repetitive elements (SINEs), has not been reported for several mammalian groups. Because SINEs occupy a large portion of the mammalian genome, they are believed to have contributed to the constitution and diversification of the host genomes during evolution. In the present study, we characterized a novel SINE family in the anteater genomes and designated it the MyrSINE family. Typical SINEs consist of a tRNA-related, a tRNA-unrelated and an AT-rich (or poly-A) region. MyrSINEs have only tRNA-related and poly-A regions; they are included in a group called t-SINE. The tRNA-related regions of the MyrSINEs were found to be derived from tRNA(Gly). We demonstrate that the MyrSINE family can be classified into three subfamilies. Two of the MyrSINE subfamilies are distributed in the genomes of both giant anteater and tamandua, while the other is present only in the giant anteater. We discuss the evolutionary history of MyrSINEs and their relationship to the evolution of anteaters. We also speculate that the simple structure of t-SINEs may be a potential evolutionary source for the generation of the typical SINE structure. PMID:17628355

  18. Impact of workstations on criticality analyses at ABB combustion engineering

    SciTech Connect

    Tarko, L.B.; Freeman, R.S.; O'Donnell, P.F. )

    1993-01-01

    During 1991, ABB Combustion Engineering (ABB C-E) made the transition from a CDC Cyber 990 mainframe for nuclear criticality safety analyses to Hewlett Packard (HP)/Apollo workstations. The primary motivation for this change was improved economics of the workstation and maintaining state-of-the-art technology. The Cyber 990 utilized the NOS operating system with a 60-bit word size. The CPU memory size was limited to 131 100 words of directly addressable memory with an extended 250000 words available. The Apollo workstation environment at ABB consists of HP/Apollo-9000/400 series desktop units used by most application engineers, networked with HP/Apollo DN10000 platforms that use 32-bit word size and function as the computer servers and network administrative CPUS, providing a virtual memory system.

  19. ABB Combustion Engineering`s nuclear experience and technologies

    SciTech Connect

    Matzie, R.A.

    1994-12-31

    ABB Combustion Engineering`s nuclear experience and technologies are outlined. The following topics are discussed: evolutionary approach using proven technology, substantial improvement to plant safety, utility perspective up front in developing design, integrated design, competitive plant cost, operability and maintainability, standardization, and completion of US NRC technical review.

  20. AUDITORY-PHONETIC PROJECTION AND LEXICAL STRUCTURE IN THE RECOGNITION OF SINE-WAVE WORDS

    PubMed Central

    Remez, Robert E.; Dubowski, Kathryn R.; Broder, Robin S.; Davids, Morgana L.; Grossman, Yael S.; Moskalenko, Marina; Pardo, Jennifer S.; Hasbun, Sara Maria

    2010-01-01

    Speech remains intelligible despite the elimination of canonical acoustic correlates of phonemes from the spectrum. A portion of this perceptual flexibility can be attributed to modulation sensitivity in the auditory-to-phonetic projection, though signal-independent properties of lexical neighborhoods also affect intelligibility in utterances composed of words. Three tests were conducted to estimate the effects of exposure to natural and sine-wave samples of speech in this kind of perceptual versatility. First, sine-wave versions of the easy/hard word sets were created, modeled on the speech samples of a single talker. The performance difference in recognition of easy and hard words was used to index the perceptual reliance on signal-independent properties of lexical contrasts. Second, several kinds of exposure produced familiarity with an aspect of sine-wave speech: 1) sine-wave sentences modeled on the same talker; 2) sine-wave sentences modeled on a different talker, to create familiarity with a sine-wave carrier; and 3) natural sentences spoken by the same talker, to create familiarity with the idiolect expressed in the sine-wave words. Recognition performance with both easy and hard sine-wave words improved after exposure only to sine-wave sentences modeled on the same talker. Third, a control test showed that signal-independent uncertainty is a plausible cause of differences in recognition of easy and hard sine-wave words. The conditions of beneficial exposure reveal the specificity of attention underlying versatility in speech perception. PMID:20865138

  1. Localization of the sine-Gordon equation solutions

    NASA Astrophysics Data System (ADS)

    Porubov, A. V.; Fradkov, A. L.; Bondarenkov, R. S.; Andrievsky, B. R.

    2016-10-01

    Localization of the waves of the sine-Gordon equation depends on the shape of the initial condition. It is shown how initially motionless Gaussian distribution may be modified to obtain propagation of localized waves in both directions. However, the resulting localized wave profile is described neither by an asymptotic envelope- wave solution to the sine-Gordon equation nor by its exact traveling breather solution. The distributed control algorithms are developed to achieve wave localization independent of the shape of the initial condition. It is shown that localization of the waves in both directions is achieved by means of a feedforward (nonfeedback) control. The waves are similar to the envelope wave solution. The feedback distributed algorithm is shown to provide both localized waves according to analytical solutions and their unidirectional propagation.

  2. The Sine Qua Non of Organizational Effectiveness

    ERIC Educational Resources Information Center

    Konnert, William; Graff, Orin B.

    1976-01-01

    The thesis of this article is that the effectiveness of an organization depends on the philosophical bases of the individuals involved. Thus, the philosophical bases from which the individuals operate are the sine qua non for organizational effectiveness. (Author)

  3. Sine-Gordon solitons in networks: Scattering and transmission at vertices

    NASA Astrophysics Data System (ADS)

    Sobirov, Zarif; Babajanov, Doniyor; Matrasulov, Davron; Nakamura, Katsuhiro; Uecker, Hannes

    2016-09-01

    We consider the sine-Gordon equation on metric graphs with simple topologies and derive vertex boundary conditions from the fundamental conservation laws together with successive space-derivatives of sine-Gordon equation. We analytically obtain traveling-wave solutions in the form of standard sine-Gordon solitons such as kinks and antikinks for star and tree graphs. We show that for this case the sine-Gordon equation becomes completely integrable just as in case of a simple 1D chain. This simple analysis provides a cornerstone for the numerical solution of the general case, including a quantification of the vertex scattering. Applications of the obtained results to Josephson junction networks and DNA double helix are discussed.

  4. Carnivore-Specific SINEs (Can-SINEs): Distribution, Evolution, and Genomic Impact

    PubMed Central

    Johnson, Diana L.E.; Allard, Marc W.; Pecon-Slattery, Jill

    2011-01-01

    Short interspersed nuclear elements (SINEs) are a type of class 1 transposable element (retrotransposon) with features that allow investigators to resolve evolutionary relationships between populations and species while providing insight into genome composition and function. Characterization of a Carnivora-specific SINE family, Can-SINEs, has, has aided comparative genomic studies by providing rare genomic changes, and neutral sequence variants often needed to resolve difficult evolutionary questions. In addition, Can-SINEs constitute a significant source of functional diversity with Carnivora. Publication of the whole-genome sequence of domestic dog, domestic cat, and giant panda serves as a valuable resource in comparative genomic inferences gleaned from Can-SINEs. In anticipation of forthcoming studies bolstered by new genomic data, this review describes the discovery and characterization of Can-SINE motifs as well as describes composition, distribution, and effect on genome function. As the contribution of noncoding sequences to genomic diversity becomes more apparent, SINEs and other transposable elements will play an increasingly large role in mammalian comparative genomics. PMID:21846743

  5. Benjamin Banneker and the Law of Sines

    ERIC Educational Resources Information Center

    Mahoney, John F.

    2005-01-01

    Benjamin Banneker, a self-taught mathematician, surveyor and astronomer published annual almanacs containing his astronomical observations and predictions. Banneker who also used logarithms to apply the Law of Sines believed that the method used to solve a mathematical problem depends on the tools available.

  6. Calculating the Weather: Deductive Reasoning and Disciplinary "Telos" in Cleveland Abbe's Rhetorical Transformation of Meteorology

    ERIC Educational Resources Information Center

    Majdik, Zoltan P.; Platt, Carrie Anne; Meister, Mark

    2011-01-01

    This paper explores the rhetorical basis of a major paradigm change in meteorology, from a focus on inductive observation to deductive, mathematical reasoning. Analysis of Cleveland Abbe's "The Physical Basis of Long-Range Weather Forecasts" demonstrates how in his advocacy for a new paradigm, Abbe navigates the tension between piety to tradition…

  7. Sine-Fitting Software for IEEE Standard 1057

    SciTech Connect

    Blair, Jerome

    1999-05-01

    Software application that performs the calculations related to the sine-fit tests of IEEE Standard 1057/94. Example outputs and explainations of these outputs to determine the important characteristics of the device under test. This application performs the calculations related to sine-fit tests and uses 4-parameter sine fit from IEEE Standard 1057-1994.

  8. Sine-square deformation and supersymmetric quantum mechanics

    NASA Astrophysics Data System (ADS)

    Okunishi, Kouichi; Katsura, Hosho

    2015-11-01

    We investigate the sine-square deformation (SSD) of free fermions in one-dimensional continuous space. On the basis of supersymmetric quantum mechanics, we prove the correspondence between the many-body ground state of the system with SSD and that of the uniform system with periodic boundary conditions. We also discuss the connection between the SSD in the continuous space and its lattice version, where the geometric correction due to the real-space deformation plays an important role in relating the eigenstates of the lattice SSD with those of the continuous SSD.

  9. A method for the in situ determination of Abbe errors and their correction

    NASA Astrophysics Data System (ADS)

    Köning, R.; Flügge, J.; Bosse, H.

    2007-02-01

    Often Abbe errors are the most important uncertainty sources in dimensional metrology applications aiming for measurement uncertainties of only a few nanometres. Abbe errors are caused by the angle deviations of relative translations between measurement object and sensing device—either in moving object or moving sensing device configuration—and the offset between the measurement axes of the machine and the measurement point of the structure localization device or the displacement sensor under investigation. The angle deviations of the motion stage can usually be determined, e.g. by an electronic autocollimator with sufficient accuracy. Unfortunately, in many cases, the Abbe offset cannot be estimated with sufficient accuracy or varies over the measurement range. In order to reduce the influence of the Abbe error many length measuring machines are equipped with control loops to reduce the angle deviations. However, in order to specify the uncertainty contribution of the residual Abbe errors, the Abbe offsets are still required. In these cases, in principle, an in situ determination of the Abbe errors is possible by the following method. First the measurement is conducted in the common way. Then two further measurements are performed during which one angle, consecutively the yaw and the pitch angle, is scanned by the angle actuators and measured by the angle sensors of the control loop. The differences of these two measurements from the first should reflect the influence of the Abbe errors and the dependence of the length measurement results on the angles can be determined. This predication was tested during the measurements of a high resolution encoder with the Nanometer Comparator. Contrary to the classical perception, the observed dependence of the Abbe error on the angle variation applied was nonlinear. However, using a polynomial of third order it is possible to correct the artificially introduced Abbe errors of up to 20 nm almost down to the noise level.

  10. Locally tuned inverse sine nonlinear technique for color image enhancement

    NASA Astrophysics Data System (ADS)

    Arigela, Saibabu; Asari, Vijayan K.

    2013-02-01

    In this paper, a novel inverse sine nonlinear transformation based image enhancement technique is proposed to improve the visual quality of images captured in extreme lighting conditions. This method is adaptive, local and simple. The proposed technique consists of four main stages namely histogram adjustment, dynamic range compression, contrast enhancement and nonlinear color restoration. Histogram adjustment on each spectral band is performed to belittle the effect of illumination. Dynamic range compression is accomplished by an inverse sine nonlinear function with a locally tunable image dependent parameter based on the local statistics of each pixel's neighborhood regions of the luminance image. A nonlinear color restoration process based on the chromatic information and luminance of the original image is employed. A statistical quantitative evaluation is performed with the state of the art techniques to analyze and compare the performance of the proposed technique. The proposed technique is also tested on face detection in complex lighting conditions. The results of this technique on images captured in hazy/foggy weather environment are also presented. The evaluation results confirm that the proposed method can be applied to surveillance, security applications in complex lighting environments.

  11. Talua SINE biology in the genome of the Reticulitermes subterranean termites (Isoptera, Rhinotermitidae).

    PubMed

    Luchetti, Andrea; Mantovani, Barbara

    2009-12-01

    Studies on transposable elements in termites are of interest because their genome is in a permanent condition of inbreeding. In this situation, an increase in transposon copy number should be mainly due to a Muller's ratchet effect, with selection against deleterious insertions playing a major role. Short INterspersed Elements (SINEs) are non-autonomous retrotransposons, known to be stable components of eukaryotic genomes. The SINE Talua, first isolated from Reticulitermes lucifugus (Rhinotermitidae), is the only mobile element described so far in termites. In the present survey, Talua has been found widespread in the Isoptera order. In comparison with other non-termite SINEs, Talua diversity and distribution in the Reticulitermes genome demonstrate that Talua is an ancient component of termite genome and that it is significantly associated with other repeats. In particular, the element is found to be involved with microsatellite motifs either as their generator or because inserted in their nearby. Further, two new SINEs and a putative retrotranscriptase-like sequence were found linked to Talua. Talua's genomic distribution is discussed in the light of the available models on transposable element dynamics within inbred genomes, also taking into account SINE role as drivers of genetic diversity in counteracting inbreeding depression.

  12. Versatility of Abbe-Estlander Flap in Lip Reconstruction – A Prospective Clinical Study

    PubMed Central

    Shetty, Premlatha M; Bhambar, Rohan Suhas; Gattumeedhi, Shashank Redddy; Kumar, Ram Mohan; Kumar, Harsh

    2014-01-01

    Aims & Objectives: Aim of this study was to evaluate the versatility of Abbe-Estlander flap in lip reconstruction with regard to function and aesthetic outcome and objectives were to present our experience and result in series of 10 cases of lip reconstruction by Abbe-Estlander flap. Materials and Methods: A total number of 10 patients were taken up in the study, age ranging from 35-71 y, mean age being 60. Out of 10 patients, 6 (60%) were male and 4 (40%) female. In all these patients, Abbe-Estlander flap that involved the commissure was used for reconstruction. Patients were recalled at intervals of three weeks, three months and six months for follow up. Results: All patients had satisfactory results in terms of aesthetic and functional outcome. Conclusion: Abbe-Estlander flap is safe and a reliable flap which is technically simple to perform, and provides functionally and aesthetically pleasing result and affords versatility in flap design. PMID:25478393

  13. The Dynamical Sine-Gordon Model

    NASA Astrophysics Data System (ADS)

    Hairer, Martin; Shen, Hao

    2016-02-01

    We introduce the dynamical sine-Gordon equation in two space dimensions with parameter {β}, which is the natural dynamic associated to the usual quantum sine-Gordon model. It is shown that when {β2 in (0, 16π/3)} the Wick renormalised equation is well-posed. In the regime {β2 in (0, 4π)}, the Da Prato-Debussche method [J Funct Anal 196(1):180-210, 2002; Ann Probab 31(4):1900-1916, 2003] applies, while for {β2 in [4π, 16π/3)}, the solution theory is provided via the theory of regularity structures [Hairer, Invent Math 198(2):269-504, 2014]. We also show that this model arises naturally from a class of {2 + 1} -dimensional equilibrium interface fluctuation models with periodic nonlinearities. The main mathematical difficulty arises in the construction of the model for the associated regularity structure where the role of the noise is played by a non-Gaussian random distribution similar to the complex multiplicative Gaussian chaos recently analysed in Lacoin et al. [Commun Math Phys 337(2):569-632, 2015].

  14. Acute effect of alcohol intake on sine-wave Cartesian and polar contrast sensitivity functions.

    PubMed

    Cavalcanti-Galdino, M K; Silva, J A da; Mendes, L C; Santos, N A da; Simas, M L B

    2014-04-01

    The aim of this study was to assess contrast sensitivity for angular frequency stimuli as well as for sine-wave gratings in adults under the effect of acute ingestion of alcohol. We measured the contrast sensitivity function (CSF) for gratings of 0.25, 1.25, 2.5, 4, 10, and 20 cycles per degree of visual angle (cpd) as well as for angular frequency stimuli of 1, 2, 4, 24, 48, and 96 cycles/360°. Twenty adults free of ocular diseases, with normal or corrected-to-normal visual acuity, and no history of alcoholism were enrolled in two experimental groups: 1) no alcohol intake (control group) and 2) alcohol ingestion (experimental group). The average concentration of alcohol in the experimental group was set to about 0.08%. We used a paradigm involving a forced-choice method. Maximum sensitivity to contrast for sine-wave gratings in the two groups occurred at 4 cpd sine-wave gratings and at 24 and 48 cycles/360° for angular frequency stimuli. Significant changes in contrast sensitivity were observed after alcohol intake compared with the control condition at spatial frequency of 4 cpd and 1, 24, and 48 cycles/360° for angular frequency stimuli. Alcohol intake seems to affect the processing of sine-wave gratings at maximum sensitivity and at the low and high frequency ends for angular frequency stimuli, both under photopic luminance conditions.

  15. Acute effect of alcohol intake on sine-wave Cartesian and polar contrast sensitivity functions

    PubMed Central

    Cavalcanti-Galdino, M.K.; da Silva, J.A.; Mendes, L.C.; dos Santos, N.A.; Simas, M.L.B.

    2014-01-01

    The aim of this study was to assess contrast sensitivity for angular frequency stimuli as well as for sine-wave gratings in adults under the effect of acute ingestion of alcohol. We measured the contrast sensitivity function (CSF) for gratings of 0.25, 1.25, 2.5, 4, 10, and 20 cycles per degree of visual angle (cpd) as well as for angular frequency stimuli of 1, 2, 4, 24, 48, and 96 cycles/360°. Twenty adults free of ocular diseases, with normal or corrected-to-normal visual acuity, and no history of alcoholism were enrolled in two experimental groups: 1) no alcohol intake (control group) and 2) alcohol ingestion (experimental group). The average concentration of alcohol in the experimental group was set to about 0.08%. We used a paradigm involving a forced-choice method. Maximum sensitivity to contrast for sine-wave gratings in the two groups occurred at 4 cpd sine-wave gratings and at 24 and 48 cycles/360° for angular frequency stimuli. Significant changes in contrast sensitivity were observed after alcohol intake compared with the control condition at spatial frequency of 4 cpd and 1, 24, and 48 cycles/360° for angular frequency stimuli. Alcohol intake seems to affect the processing of sine-wave gratings at maximum sensitivity and at the low and high frequency ends for angular frequency stimuli, both under photopic luminance conditions. PMID:24676473

  16. Synthesis, structures and electrochemical and photophysical properties of anilido-benzoxazole boron difluoride (ABB) complexes.

    PubMed

    Meesala, Yedukondalu; Kavala, Veerababurao; Chang, Hao-Ching; Kuo, Ting-Shen; Yao, Ching-Fa; Lee, Way-Zen

    2015-01-21

    A new series of four-ring-fused π-conjugated anilido-benzoxazole boron difluoride (ABB) dyes were synthesized by employing an unsymmetrical bidentate ligand under a mild reaction condition. X-ray structural analysis demonstrated that the four-ring-fused π-conjugated skeleton is nearly coplanar, and almost orthogonal to the side anilido phenyl group with dihedral angles of 74-86°. The synthesized complexes exhibit very bright luminescence in solution (Φf = 0.45-0.96 in CH2Cl2) and in the solid-state (Φf = 0.07-0.37). These complexes show a larger Stokes shift (56-128 nm) than the well-known boron dipyrromethene dyes (8-12 nm, in most cases). The role of molecular packing patterns elucidated by the assistance of their X-ray crystal structures rationalizes the solid-state fluorescence. One of the tested compounds displayed aggregation induced emission (AIE). First-principle-based quantum-chemical studies were carried out on complexes . Time-dependent DFT (TD-DFT) calculations support the experimental results. The participation of the anilido phenyl moiety and the fluorine atoms was found to be negligible in the LUMO orbitals.

  17. Virtual sine arm kinematic mount system

    SciTech Connect

    Xu, Z.; Randall, K.J.

    1997-09-01

    A novel kinematic mount system for a vertical focusing mirror of the soft x-ray spectroscopy beamline at the Advanced Photon Source is described. The system contains three points in a horizontal plane. Each point consists of two horizontal linear precision stages, a spherical ball bearing, and a vertical precision stage. The horizontal linear stages are aligned orthogonally and are conjoined by a spherical ball bearing, supported by the vertical linear stage at each point. The position of each confined horizontal stage is controlled by a motorized micrometer head by spring-loading the flat tip of the micrometer head onto a tooling ball fixing on the carriage of the stage. A virtual sine arm is formed by tilting the upstream horizontal stage down and the two downstream horizontal stages up by a small angle. The fine pitch motion is achieved by adjusting the upstream stage. This supporting structure is extremely steady due to a relatively large span across the supporting points and yields extremely high resolution on the pitch motion. With a one degree tilt and a microstepping motor, the authors achieved a 0.4 nanoradian resolution on the mirror pitch motion.

  18. The Perception of "Sine-Wave Speech" by Adults with Developmental Dyslexia.

    ERIC Educational Resources Information Center

    Rosner, Burton S.; Talcott, Joel B.; Witton, Caroline; Hogg, James D.; Richardson, Alexandra J.; Hansen, Peter C.; Stein, John F.

    2003-01-01

    "Sine-wave speech" sentences contain only four frequency-modulated sine waves, lacking many acoustic cues present in natural speech. Adults with (n=19) and without (n=14) dyslexia were asked to reproduce orally sine-wave utterances in successive trials. Results suggest comprehension of sine-wave sentences is impaired in some adults with dyslexia.…

  19. Brain-wave representation of words by superposition of a few sine waves

    PubMed Central

    Suppes, Patrick; Han, Bing

    2000-01-01

    Data from three previous experiments were analyzed to test the hypothesis that brain waves of spoken or written words can be represented by the superposition of a few sine waves. First, we averaged the data over trials and a set of subjects, and, in one case, over experimental conditions as well. Next we applied a Fourier transform to the averaged data and selected those frequencies with high energy, in no case more than nine in number. The superpositions of these selected sine waves were taken as prototypes. The averaged unfiltered data were the test samples. The prototypes were used to classify the test samples according to a least-squares criterion of fit. The results were seven of seven correct classifications for the first experiment using only three frequencies, six of eight for the second experiment using nine frequencies, and eight of eight for the third experiment using five frequencies. PMID:10890906

  20. Short interspersed elements (SINEs) from insectivores. Two classes of mammalian SINEs distinguished by A-rich tail structure.

    PubMed

    Borodulina, O R; Kramerov, D A

    2001-10-01

    Four tRNA-related SINE families were isolated from the genome of the shrew Sorex araneus (SOR element), mole Mogera robusta (TAL element), and hedgehog Mesechinus dauuricus (ERI-1 and ERI-2 elements). Each of these SINEs families is specific for a single Insectivora family: SOR, for Soricidae (shrews); TAL, for Talpidae (moles and desmans); ERI-1 and ERI-2, for Erinaceidae (hedgehogs). There is a long polypyrimidine region (TC-motif) in TAL, ERI-1, and ERI-2 elements located immediately upstream of an A-rich tail with polyadenylation signals (AATAAA) and an RNA polymerase III terminator (T(4-6)) or TCT(3-4)). Ten out of 14 analyzed mammalian tRNA-related SINE families have an A-rich tail similar to that of TAL, ERI-1, and ERI-2 elements. These elements were assigned to class T+. The other four SINEs including SOR element have no polyadenylation signal and transcription terminator in their A-rich tail and were assigned to class T-. Class T+ SINEs occur only in mammals, and most of them have a long polypyrimidine region. Possible models of retroposition of class T+ and T- SINEs are discussed.

  1. Synchrony of two uncoupled neurons under half wave sine current stimulation

    NASA Astrophysics Data System (ADS)

    Peng, Yueping; Wang, Jue; Jian, Zhong

    2009-04-01

    Two uncoupled Hindmarsh-Rose neurons under different initial discharge patterns are stimulated by the half wave sine current; and the synchronization mechanism of the two neurons is discussed by analyzing their membrane potentials and their interspike interval (ISI) distribution. Under the half wave sine current stimulation, the two uncoupled neurons under different initial conditions, whose parameter r (the parameter r is related to the membrane penetration of calcium ion, and reflects the changing speed of the slow adaptation current) is different or the same, can realize discharge synchronization (phase synchronization) or the full synchronization (state synchronization). The synchronization characteristics are mainly related to the frequency and the amplitude of the half wave sine current, and are little related to the parameter r and the initial state of the two neurons. This investigation shows the mechanism of the current's amplitude and its frequency affecting the synchronization process of neurons, and the neurons' discharge patterns and synchronization process can be adjusted and controlled by the current's amplitude and its frequency. This result is of far reaching importance to study synchronization and encode of many neurons or neural network, and provides the theoretic basis for studying the mechanism of some nervous diseases such as epilepsy and Alzheimer's disease by the slow wave of EEG.

  2. Application of the sine-Poisson equation in solar magnetostatics

    NASA Technical Reports Server (NTRS)

    Webb, G. M.; Zank, G. P.

    1990-01-01

    Solutions of the sine-Poisson equations are used to construct a class of isothermal magnetostatic atmospheres, with one ignorable coordinate corresponding to a uniform gravitational field in a plane geometry. The distributed current in the model (j) is directed along the x-axis, where x is the horizontal ignorable coordinate; (j) varies as the sine of the magnetostatic potential and falls off exponentially with distance vertical to the base with an e-folding distance equal to the gravitational scale height. Solutions for the magnetostatic potential A corresponding to the one-soliton, two-soliton, and breather solutions of the sine-Gordon equation are studied. Depending on the values of the free parameters in the soliton solutions, horizontally periodic magnetostatic structures are obtained possessing either a single X-type neutral point, multiple neural X-points, or solutions without X-points.

  3. Refractive-index measurements in the near-IR using an Abbe refractometer

    NASA Astrophysics Data System (ADS)

    Rheims, J.; Köser, J.; Wriedt, T.

    1997-06-01

    A novel method to measure the refractive index n in the near-infrared by simple extensions to a standard Abbe refractometer is described. A technique is derived to correct for the dispersion of the glass prism and experimental results of refractive-index measurements at 0957-0233/8/6/003/img6 are compared with published data. These results prove the suitability of the described method, the accuracy being comparable to that of an Abbe refractometer used in the visible range; that is, the refractive index n can be measured to an accuracy of 0957-0233/8/6/003/img7. Finally, new refractive-index data at 830 nm are given for methanol, water, acetone, ethanol, cyclohexane, glycol, di-2-ethyl hexyl-sabacate (DEHS), carbon tetrachloride, glycerol, toluene, ethyl salicylate, methyl salicylate and cinnamaldehyde at 20 and 0957-0233/8/6/003/img8.

  4. Abbe's number and Cauchy's constant of iodine and selenium doped poly (methylmethacrylate) and polystyrene composites

    SciTech Connect

    Mehta, Sheetal Das, Kallol Keller, Jag Mohan

    2014-04-24

    Poly (methyl methacrylate) / Polystyrene and iodine / selenium hybrid matrixes have been prepared and characterized. Refractive index measurements were done at 390, 535, 590, 635 nm wavelengths. Abbe's number and Cauchy's constants of the iodine / selenium doped poly (methylmethacrylate) and polystyrene samples are being reported. The results also showed that the refractive index of the composite varies non-monotonically with the doping concentration at low iodine concentration or in the region of nanoparticles formation and is also dependent on thermal annealing.

  5. Abbe's number and Cauchy's constant of iodine and selenium doped poly (methylmethacrylate) and polystyrene composites

    NASA Astrophysics Data System (ADS)

    Mehta, Sheetal; Das, Kallol; Keller, Jag Mohan

    2014-04-01

    Poly (methyl methacrylate) / Polystyrene and iodine / selenium hybrid matrixes have been prepared and characterized. Refractive index measurements were done at 390, 535, 590, 635 nm wavelengths. Abbe's number and Cauchy's constants of the iodine / selenium doped poly (methylmethacrylate) and polystyrene samples are being reported. The results also showed that the refractive index of the composite varies non-monotonically with the doping concentration at low iodine concentration or in the region of nanoparticles formation and is also dependent on thermal annealing.

  6. Explicitly solvable complex Chebyshev approximation problems related to sine polynomials

    NASA Technical Reports Server (NTRS)

    Freund, Roland

    1989-01-01

    Explicitly solvable real Chebyshev approximation problems on the unit interval are typically characterized by simple error curves. A similar principle is presented for complex approximation problems with error curves induced by sine polynomials. As an application, some new explicit formulae for complex best approximations are derived.

  7. Generalized universality in the massive sine-Gordon model

    SciTech Connect

    Nagy, S.; Sailer, K.; Nandori, I.; Polonyi, J.

    2008-01-15

    A nontrivial interplay of the UV and IR scaling laws, a generalization of the universality is demonstrated in the framework of the massive sine-Gordon model, as a result of a detailed study of the global behavior of the renormalization group flow and the phase structure.

  8. Stochastic D-bifurcation for a damped sine-Gordon equation with noise

    SciTech Connect

    Huang, Qiongwei; Xue, Changfeng; Tang, Jiashi

    2015-04-15

    We investigate the stochastic bifurcation of a damped sine-Gordon equation with Dirichlet boundary conditions under the influence of multiplicative Gaussian white noise. Introducing a slow time scale, we derive the amplitude equations near the trivial solution by multiscale analysis. And the stationary probability density functions are formulated analytically using the stochastic averaging of energy envelope. The numerical calculations show that the system undergoes a stochastic D-bifurcation of energy envelope from a delta measure to new stationary measures when the control parameter crosses a critical point.

  9. Chaos in a model of the forced and damped Sine-Gordon equation

    SciTech Connect

    Kovacic, G.

    1990-01-01

    The author analytically determines two of the mechanisms which cause chaotic dynamics to appear in a model of the forced and damped Sine Gordon equation. In particular, he finds orbits homoclinic to periodic orbits, and orbits homoclinic to fixed points which satisfy conditions sufficient to guarantee the existence of nearby chaotic invariant sets. One of these homoclinic orbits is a so-called Silnikov-type loop. A proof the existence of a symmetric pair of such loops is the main result. This proof consists of a modified Melnikov perturbation analysis, augmented by some techniques from the field of geometric singular perturbation theory.

  10. Radial sine-Gordon kinks as sources of fast breathers.

    PubMed

    Caputo, J-G; Soerensen, M P

    2013-08-01

    We consider radial sine-Gordon kinks in two, three, and higher dimensions. A full two-dimensional simulation showing that azimuthal perturbations remain small allows us to reduce the problem to the one-dimensional radial sine-Gordon equation. We solve this equation on an interval [r(0),r(1)] and absorb all outgoing radiation. As the kink shrinks toward r(0), before the collision, its motion is well described by a simple law derived from the conservation of energy. In two dimensions for r(0)≤2, the collision disintegrates the kink into a fast breather, while for r(0)≥4 we obtain a kink-breather metastable state where breathers are shed at each kink "return." In three and higher dimensions d, an additional kink-oscillon state appears for small r(0). On the application side, the kink disintegration opens the way for new types of terahertz microwave generators.

  11. Kinematic analysis of tandem gait on a sine wave walkway

    PubMed Central

    Kawakami, Shingo; Fujisawa, Hiroyuki; Tomizawa, Yoshiyuki; Murakami, Kenichi

    2016-01-01

    [Purpose] The purpose of this study was to ascertain the kinematic characteristics on a horizontal plane, including knee joint rotation, when walking with a tandem gait on a sine wave walkway. [Subjects and Methods] Eighteen healthy adults were enrolled as subjects in this study. They walked with a tandem gait on a sine wave walkway. A three-dimensional motion analysis system was used to record data and calculate the trunk, hip joint, and knee joint rotation angles. [Results] The rotation angle ranges for the trunk, hip joint, and knee joint were 23.3°, 53.3°, and 47.3°, respectively. The trunk generally rotated towards the direction of movement, and when turning left using the left leg as the pivot, the hip joint was internally rotated and the knee joint was externally rotated. In contrast, when making a directional change to the right using the left leg as the pivot, the hip joint was externally rotated and the knee joint was internally rotated. [Conclusion] Through tandem gait analysis on a sine wave walkway, knee joint rotation was found to be important in changes of direction. PMID:27799663

  12. Polypteridae (Actinopterygii: Cladistia) and DANA-SINEs insertions.

    PubMed

    Morescalchi, Maria Alessandra; Barucca, Marco; Stingo, Vincenzo; Capriglione, Teresa

    2010-06-01

    SINE sequences are interspersed throughout virtually all eukaryotic genomes and greatly outnumber the other repetitive elements. These sequences are of increasing interest for phylogenetic studies because of their diagnostic power for establishing common ancestry among taxa, once properly characterized. We identified and characterized a peculiar family of composite tRNA-derived short interspersed SINEs, DANA-SINEs, associated with mutational activities in Danio rerio, in a group of species belonging to one of the most basal bony fish families, the Polypteridae, in order to investigate their own inner specific phylogenetic relationships. DANA sequences were identified, sequenced and then localized, by means of fluorescent in situ hybridization (FISH), in six Polypteridae species (Polypterus delhezi, P. ornatipinnis, P. palmas, P. buettikoferi P. senegalus and Erpetoichthys calabaricus) After cloning, the sequences obtained were aligned for phylogenetic analysis, comparing them with three Dipnoan lungfish species (Protopterus annectens, P. aethiopicus, Lepidosiren paradoxa), and Lethenteron reissneri (Petromyzontidae)was used as outgroup. The obtained overlapping MP, ML and NJ tree clustered together the species belonging to the two taxonomically different Osteichthyans groups: the Polypteridae, by one side, and the Protopteridae by the other, with the monotypic genus Erpetoichthys more distantly related to the Polypterus genus comprising three distinct groups: P. palmas and P. buettikoferi, P. delhezi and P. ornatipinnis and P. senegalus. In situ hybridization with DANA probes marked along the whole chromosome arms in the metaphases of all the Polypteridae species examined. PMID:21798200

  13. Extending resolution of scanning optical microscopy beyond the Abbe limit through the assistance of InSb thin layers.

    PubMed

    Ding, Chenliang; Wei, Jingsong; Li, Qisong; Liang, Xin; Wei, Tao

    2016-04-01

    The resolution of light imaging is required to extend beyond the Abbe limit to the subdiffraction, or even nanoscale. In this Letter, we propose to extend the resolution of scanning optical microscopy (SOM) beyond the Abbe limit as a kind of subdiffraction imaging technology through the assistance of InSb thin layers due to obvious nonlinear saturation absorption and reversible formation of an optical pinhole channel. The results show that the imaging resolution is greatly improved compared with the SOM itself. This work provides a way to improve the resolution of SOM without changing the SOM itself, but through the assistance of InSb thin layers. This is also a simple and practical way to extend the resolution of SOM beyond the Abbe limit.

  14. The dynamic proliferation of CanSINEs mirrors the complex evolution of Feliforms

    PubMed Central

    2014-01-01

    Background Repetitive short interspersed elements (SINEs) are retrotransposons ubiquitous in mammalian genomes and are highly informative markers to identify species and phylogenetic associations. Of these, SINEs unique to the order Carnivora (CanSINEs) yield novel insights on genome evolution in domestic dogs and cats, but less is known about their role in related carnivores. In particular, genome-wide assessment of CanSINE evolution has yet to be completed across the Feliformia (cat-like) suborder of Carnivora. Within Feliformia, the cat family Felidae is composed of 37 species and numerous subspecies organized into eight monophyletic lineages that likely arose 10 million years ago. Using the Felidae family as a reference phylogeny, along with representative taxa from other families of Feliformia, the origin, proliferation and evolution of CanSINEs within the suborder were assessed. Results We identified 93 novel intergenic CanSINE loci in Feliformia. Sequence analyses separated Feliform CanSINEs into two subfamilies, each characterized by distinct RNA polymerase binding motifs and phylogenetic associations. Subfamily I CanSINEs arose early within Feliformia but are no longer under active proliferation. Subfamily II loci are more recent, exclusive to Felidae and show evidence for adaptation to extant RNA polymerase activity. Further, presence/absence distributions of CanSINE loci are largely congruent with taxonomic expectations within Feliformia and the less resolved nodes in the Felidae reference phylogeny present equally ambiguous CanSINE data. SINEs are thought to be nearly impervious to excision from the genome. However, we observed a nearly complete excision of a CanSINEs locus in puma (Puma concolor). In addition, we found that CanSINE proliferation in Felidae frequently targeted existing CanSINE loci for insertion sites, resulting in tandem arrays. Conclusions We demonstrate the existence of at least two SINE families within the Feliformia suborder, one

  15. Recognition of sine wave modeled consonants by normal hearing and hearing-impaired individuals

    NASA Astrophysics Data System (ADS)

    Balachandran, Rupa

    Sine wave modeling is a parametric tool for representing the speech signal with a limited number of sine waves. It involves replacing the peaks of the speech spectrum with sine waves and discarding the rest of the lower amplitude components during synthesis. It has the potential to be used as a speech enhancement technique for hearing-impaired adults. The present study answers the following basic questions: (1) Are sine wave synthesized speech tokens more intelligible than natural speech tokens? (2) What is the effect of varying the number of sine waves on consonant recognition in quiet? (3) What is the effect of varying the number of sine waves on consonant recognition in noise? (4) How does sine wave modeling affect the transmission of speech feature in quiet and in noise? (5) Are there differences in recognition performance between normal hearing and hearing-impaired listeners? VCV syllables representing 20 consonants (/p/, /t/, /k/, /b/, /d/, /g/, /f/, /theta/, /s/, /∫/, /v/, /z/, /t∫/, /dy/, /j/, /w/, /r/, /l/, /m/, /n/) in three vowel contexts (/a/, /i/, /u/) were modeled with 4, 8, 12, and 16 sine waves. A consonant recognition task was performed in quiet, and in background noise (+10 dB and 0 dB SNR). Twenty hearing-impaired listeners and six normal hearing listeners were tested under headphones at their most comfortable listening level. The main findings were: (1) Recognition of unprocessed speech was better that of sine wave modeled speech. (2) Asymptotic performance was reached with 8 sine waves in quiet for both normal hearing and hearing-impaired listeners. (3) Consonant recognition performance in noise improved with increasing number of sine waves. (4) As the number of sine waves was decreased, place information was lost first, followed by manner, and finally voicing. (5) Hearing-impaired listeners made more errors then normal hearing listeners, but there were no differences in the error patterns made by both groups.

  16. Linear sine wave profiling to machine instability targets

    DOE PAGES

    Schmidt, Derek William; Martinez, John Israel

    2016-08-01

    Specialized machining processes and programming have been developed to deliver thin tin and copper Richtmyer-Meshkov instability targets that have different amplitude perturbations across the face of one 4-in.-diameter target. Typical targets have anywhere from two to five different regions of sine waves that have different amplitudes varying from 4 to 200 μm across the face of the target. The puck is composed of multiple rings that are zero press fit together and diamond turned to create a flat platform with a tolerance of 2 μm for the shock experiment. A custom software program was written in Labview to write themore » point-to-point program for the diamond-turning profiler through the X-Y-Z movements to cut the pure planar straight sine wave geometry. As a result, the software is optimized to push the profile of the whole part into the face while eliminating any unneeded passes that do not cut any material.« less

  17. Breather-like structures in modified sine-Gordon models

    NASA Astrophysics Data System (ADS)

    Ferreira, L. A.; Zakrzewski, Wojtek J.

    2016-05-01

    We report analytical and numerical results on breather-like field configurations in a theory which is a deformation of the integrable sine-Gordon model in (1  +  1) dimensions. The main motivation of our study is to test the ideas behind the recently proposed concept of quasi-integrability, which emerged from the observation that some field theories possess an infinite number of quantities which are asymptotically conserved in the scattering of solitons, and periodic in time in the case of breather-like configurations. Even though the mechanism responsible for such phenomena is not well understood yet, it is clear that special properties of the solutions under a space-time parity transformation play a crucial role. The numerical results of the present paper give support for the ideas on quasi-integrability, as it is found that extremely long-lived breather configurations satisfy these parity properties. We also report on a mechanism, particular to the theory studied here, that favours the existence of long lived breathers even in cases of significant deformations of the sine-Gordon potential. We also find numerically that our breather-like configurations decay through the gradual increase of their frequency of oscillations.

  18. Criticality in self-dual sine-Gordon models

    NASA Astrophysics Data System (ADS)

    Lecheminant, P.; Gogolin, Alexander O.; Nersesyan, Alexander A.

    2002-09-01

    We discuss the nature of criticality in the β2=2 πN self-dual extension of the sine-Gordon model. This field theory is related to the two-dimensional classical XY model with a N-fold degenerate symmetry-breaking field. We briefly overview the already studied cases N=2,4 and analyze in detail the case N=3 where a single phase transition in the three-state Potts universality class is expected to occur. The Z3 infrared critical properties of the β2=6 π self-dual sine-Gordon model are derived using two non-perturbative approaches. On one hand, we map the model onto an integrable deformation of the Z4 parafermion theory. The latter is known to flow to a massless Z3 infrared fixed point. Another route is based on the connection with a chirally asymmetric, su(2) 4⊗su(2) 1 Wess-Zumino-Novikov-Witten model with anisotropic current-current interaction, where we explore the existence of a decoupling (Toulouse) point.

  19. Resonant phase dynamics in 0- π Sine-Gordon facets

    NASA Astrophysics Data System (ADS)

    Rotoli, Giacomo; Stornaiuolo, Daniela; Cedergren, Karin; Leo, Antonio; Bauch, Thilo; Lombardi, Filomena; Tafuri, Francesco

    2015-09-01

    A locally phase-shifted Sine-Gordon model well accounts for the phenomenology of unconventional Josephson junctions. The phase dynamics shows resonant modes similar to Fiske modes that appear both in the presence and in the absence of the external magnetic field in standard junctions. In the latter case, they are also in competition with zero field propagation of Sine-Gordon solitons, i.e., fluxons, which give rise to the so-called zero field steps in the current-voltage (I-V) of the junction. We numerically study the I-V characteristics and the resonances magnetic field patterns for some different faceting configurations, in various dissipative regimes, as a function of temperature. The simulated dynamics of the phase is analyzed for lower-order resonances. We give evidence of a nontrivial dynamics due to the interaction of propagating fluxons with localized semifluxons. Numerical results are compared with experimental outcomes obtained on high-quality high-Tc grain boundary YBCO junctions.

  20. Multisymplectic approach to integrable defects in the sine-Gordon model

    NASA Astrophysics Data System (ADS)

    Caudrelier, Vincent

    2015-05-01

    Ideas from the theory of multisymplectic systems, introduced recently in integrable systems by the author and Kundu to discuss Liouville integrability in classical field theories with a defect, are applied to the sine-Gordon model. The key ingredient is the introduction of a second Poisson bracket in the theory that allows for a Hamiltonian description of the model that is completely equivalent to the standard one, in the absence of a defect. In the presence of a defect described by frozen Bäcklund transformations, our approach based on the new bracket unifies the various tools used so far to attack the problem. It also gets rid of the known issues related to the evaluation of the Poisson brackets of the defect matrix which involve fields at coinciding space point (the location of the defect). The original Lagrangian approach also finds a nice reinterpretation in terms of the canonical transformation representing the defect conditions.

  1. Experimental Analysis of a Piezoelectric Energy Harvesting System for Harmonic, Random, and Sine on Random Vibration

    SciTech Connect

    Cryns, Jackson W.; Hatchell, Brian K.; Santiago-Rojas, Emiliano; Silvers, Kurt L.

    2013-07-01

    Formal journal article Experimental analysis of a piezoelectric energy harvesting system for harmonic, random, and sine on random vibration Abstract: Harvesting power with a piezoelectric vibration powered generator using a full-wave rectifier conditioning circuit is experimentally compared for varying sinusoidal, random and sine on random (SOR) input vibration scenarios. Additionally, the implications of source vibration characteristics on harvester design are discussed. Studies in vibration harvesting have yielded numerous alternatives for harvesting electrical energy from vibrations but piezoceramics arose as the most compact, energy dense means of energy transduction. The rise in popularity of harvesting energy from ambient vibrations has made piezoelectric generators commercially available. Much of the available literature focuses on maximizing harvested power through nonlinear processing circuits that require accurate knowledge of generator internal mechanical and electrical characteristics and idealization of the input vibration source, which cannot be assumed in general application. In this manuscript, variations in source vibration and load resistance are explored for a commercially available piezoelectric generator. We characterize the source vibration by its acceleration response for repeatability and transcription to general application. The results agree with numerical and theoretical predictions for in previous literature that load optimal resistance varies with transducer natural frequency and source type, and the findings demonstrate that significant gains are seen with lower tuned transducer natural frequencies for similar source amplitudes. Going beyond idealized steady state sinusoidal and simplified random vibration input, SOR testing allows for more accurate representation of real world ambient vibration. It is shown that characteristic interactions from more complex vibrational sources significantly alter power generation and power processing

  2. Scenario Based Approach for Multiple Source Tsunami Hazard Assessment for Sines, Portugal

    NASA Astrophysics Data System (ADS)

    Wronna, Martin; Omira, Rachid; Baptista, Maria Ana

    2015-04-01

    In this paper, we present a scenario-based approach for tsunami hazard assessment for the city and harbour of Sines, Portugal one the test-sites of project ASTARTE. Sines holds one of the most important deep-water ports which contains oil-bearing, petrochemical, liquid bulk, coal and container terminals. The port and its industrial infrastructures are facing the ocean to the southwest facing the main seismogenic sources. This work considers two different seismic zones: the Southwest Iberian Margin and the Gloria Fault. Within these two regions, a total of five scenarios were selected to assess tsunami impact at the test site. These scenarios correspond to the worst-case credible scenario approach based upon the largest events of the historical and paleo tsunami catalogues. The tsunami simulations from the source area towards the coast is carried out using NSWING a Non-linear Shallow Water Model With Nested Grids. The code solves the non-linear shallow water equations using the discretization and explicit leap-frog finite difference scheme, in a Cartesian or Spherical frame. The initial sea surface displacement is assumed to be equal to the sea bottom deformation that is computed by Okada equations. Both uniform and non-uniform slip conditions are used. The presented results correspond to the models using non-uniform slip conditions. In this study, the static effect of tides is analysed for three different tidal stages MLLW (mean lower low water) MSL (mean sea level) and MHHW (mean higher high water). For each scenario, inundation is described by maximum values of wave height, flow depth, drawdown, run-up and inundation distance. Synthetic waveforms are computed at virtual tide gages at specific locations outside and inside the harbour. The final results consist of Aggregate Scenario Maps presented for the different inundation parameters. This work is funded by ASTARTE - Assessment, Strategy And Risk Reduction for Tsunamis in Europe - FP7-ENV2013 6.4-3, Grant 603839

  3. V-SINEs: A New Superfamily of Vertebrate SINEs That Are Widespread in Vertebrate Genomes and Retain a Strongly Conserved Segment within Each Repetitive Unit

    PubMed Central

    Ogiwara, Ikuo; Miya, Masaki; Ohshima, Kazuhiko; Okada, Norihiro

    2002-01-01

    We have identified a new superfamily of vertebrate short interspersed repetitive elements (SINEs), designated V-SINEs, that are widespread in fishes and frogs. Each V-SINE includes a central conserved domain preceded by a 5′-end tRNA-related region and followed by a potentially recombinogenic (TG)n tract, with a 3′ tail derived from the 3′ untranslated region (UTR) of the corresponding partner long interspersed repetitive element (LINE) that encodes a functional reverse transcriptase. The central domain is strongly conserved and is even found in SINEs in the lamprey genome, suggesting that V-SINEs might be ∼550 Myr old or older in view of the timing of divergence of the lamprey lineage from the bony fish lineage. The central conserved domain might have been subject to some form of positive selection. Although the contemporary 3′ tails of V-SINEs differ from one another, it is possible that the original 3′ tail might have been replaced, via recombination, by the 3′ tails of more active partner LINEs, thereby retaining retropositional activity and the ability to survive for long periods on the evolutionary time scale. It seems plausible that V-SINEs may have some function(s) that have been maintained by the coevolution of SINEs and LINEs during the evolution of vertebrates. [The sequences reported in this paper have been deposited in the DDBJ/GenBank database under accession nos. AB072981–AB073004. Supplemental figures are available online at http://www.genome.org.] PMID:11827951

  4. Inverse PCR-based method for isolating novel SINEs from genome.

    PubMed

    Han, Yawei; Chen, Liping; Guan, Lihong; He, Shunping

    2014-04-01

    Short interspersed elements (SINEs) are moderately repetitive DNA sequences in eukaryotic genomes. Although eukaryotic genomes contain numerous SINEs copy, it is very difficult and laborious to isolate and identify them by the reported methods. In this study, the inverse PCR was successfully applied to isolate SINEs from Opsariichthys bidens genome in Eastern Asian Cyprinid. A group of SINEs derived from tRNA(Ala) molecular had been identified, which were named Opsar according to Opsariichthys. SINEs characteristics were exhibited in Opsar, which contained a tRNA(Ala)-derived region at the 5' end, a tRNA-unrelated region, and AT-rich region at the 3' end. The tRNA-derived region of Opsar shared 76 % sequence similarity with tRNA(Ala) gene. This result indicated that Opsar could derive from the inactive or pseudogene of tRNA(Ala). The reliability of method was tested by obtaining C-SINE, Ct-SINE, and M-SINEs from Ctenopharyngodon idellus, Megalobrama amblycephala, and Cyprinus carpio genomes. This method is simpler than the previously reported, which successfully omitted many steps, such as preparation of probes, construction of genomic libraries, and hybridization. PMID:24122282

  5. Mobile Element Evolution Playing Jigsaw—SINEs in Gastropod and Bivalve Mollusks

    PubMed Central

    Matetovici, Irina; Sajgo, Szilard; Ianc, Bianca; Ochis, Cornelia; Bulzu, Paul; Popescu, Octavian; Damert, Annette

    2016-01-01

    SINEs (Short INterspersed Elements) are widely distributed among eukaryotes. Some SINE families are organized in superfamilies characterized by a shared central domain. These central domains are conserved across species, classes, and even phyla. Here we report the identification of two novel such superfamilies in the genomes of gastropod and bivalve mollusks. The central conserved domain of the first superfamily is present in SINEs in Caenogastropoda and Vetigastropoda as well as in all four subclasses of Bivalvia. We designated the domain MESC (Romanian for MElc—snail and SCoica—mussel) because it appears to be restricted to snails and mussels. The second superfamily is restricted to Caenogastropoda. Its central conserved domain—Snail—is related to the Nin-DC domain. Furthermore, we provide evidence that a 40-bp subdomain of the SINE V-domain is conserved in SINEs in mollusks and arthropods. It is predicted to form a stable stem-loop structure that is preserved in the context of the overall SINE RNA secondary structure in invertebrates. Our analysis also recovered short retrotransposons with a Long INterspersed Element (LINE)-derived 5′ end. These share the body and/or the tail with transfer RNA (tRNA)-derived SINEs within and across species. Finally, we identified CORE SINEs in gastropods and bivalves—extending the distribution range of this superfamily. PMID:26739168

  6. Searching transients in large-scale surveys. A method based on the Abbe value

    NASA Astrophysics Data System (ADS)

    Mowlavi, N.

    2014-08-01

    Aims: A new method is presented to identify transient candidates in large-scale surveys based on the variability pattern in their light curves. Methods: The method is based on the Abbe value, Ab, that estimates the smoothness of a light curve, and on a newly introduced value called the excess Abbe and denoted excessAb, that estimates the regularity of the light curve variability pattern over the duration of the observations. Results: Based on simulated light curves, transients are shown to occupy a specific region in the {diagram} diagram, distinct from sources presenting pulsating-like features in their light curves or having featureless light curves. The method is tested on real light curves taken from EROS-2 and OGLE-II surveys in a 0.50° × 0.17° field of the sky in the Large Magellanic Cloud centered at RA(J2000) = 5h25m56.5s and Dec(J2000) = -69d29m43.3s. The method identifies 43 EROS-2 transient candidates out of a total of 1300 variable stars, and 19 more OGLE-II candidates, 10 of which do not have any EROS-2 variable star matches and which would need further confirmation to assess their reliability. The efficiency of the method is further tested by comparing the list of transient candidates with known Be stars in the literature. It is shown that all Be stars known in the studied field of view with detectable bursts or outbursts are successfully extracted by the method. In addition, four new transient candidates displaying bursts and/or outbursts are found in the field, of which at least two are good new Be candidates. Conclusions: The new method proves to be a potentially powerful tool to extract transient candidates from large-scale multi-epoch surveys. The better the photometric measurement uncertainties are, the cleaner the list of detected transient candidates is. In addition, the diagram diagram is shown to be a good diagnostic tool to check the data quality of multi-epoch photometric surveys. A trend of instrumental and/or data reduction origin

  7. Zero temperature landscape of the random sine-Gordon model

    SciTech Connect

    Sanchez, A.; Bishop, A.R.; Cai, D.

    1997-04-01

    We present a preliminary summary of the zero temperature properties of the two-dimensional random sine-Gordon model of surface growth on disordered substrates. We found that the properties of this model can be accurately computed by using lattices of moderate size as the behavior of the model turns out to be independent of the size above certain length ({approx} 128 x 128 lattices). Subsequently, we show that the behavior of the height difference correlation function is of (log r){sup 2} type up to a certain correlation length ({xi} {approx} 20), which rules out predictions of log r behavior for all temperatures obtained by replica-variational techniques. Our results open the way to a better understanding of the complex landscape presented by this system, which has been the subject of very many (contradictory) analysis.

  8. Chlamydia trachomatis infection in "sine causa" recurrent abortion.

    PubMed

    Olliaro, P; Regazzetti, A; Gorini, G; Milano, F; Marchetti, A; Rondanelli, E G

    One hundred and one women suffering from "sine causa" recurrent abortion were screened for Chlamydia trachomatis (C.T.) infection by using direct examination, cultural and serological procedures. In this series, C.T. infection did not appear to be related to increased risk of recurrent abortion. The culture-positive and serology-positive rates (14.85% and 34.65%, respectively) did not differ from other unselected populations. Neither time from last abortion nor type of abortion were significantly related to C.T. infection. Nonetheless, the women who underwent examination within one year from last abortion and had a culture-positive partner as well, were more likely to present with a C.T.-positive culture.

  9. Rapid fabrication and characterization of sine wave targets

    SciTech Connect

    Day, R.D.; Armijo, E.; Gobby, P.; Hatch, D.; Rivera, G.; Salzer, L.; Townsend, J.

    1997-09-01

    The effect of surface perturbations on Inertial Confinement Fusion target performance is currently being researched at Los Alamos National Laboratory (LANL). These perturbations can cause hydrodynamic instabilities which in turn reduce the targets` yield. To systematically measure the growth of these instabilities requires targets to be produced which have perturbations of a known amplitude and spatial frequency. The authors have recently assembled hardware onto one of their diamond turning lathes which enables them to machine and measure these sine waves in about 15 minutes. This is a significant reduction in time from the two and one half hours required by the previous method. This paper discusses the hardware, how it works, and how well the system is working for them to produce these targets.

  10. Rocket measurements of electron density irregularities during MAC/SINE

    NASA Technical Reports Server (NTRS)

    Ulwick, J. C.

    1989-01-01

    Four Super Arcas rockets were launched at the Andoya Rocket Range, Norway, as part of the MAC/SINE campaign to measure electron density irregularities with high spatial resolution in the cold summer polar mesosphere. They were launched as part of two salvos: the turbulent/gravity wave salvo (3 rockets) and the EISCAT/SOUSY radar salvo (one rocket). In both salvos meteorological rockets, measuring temperature and winds, were also launched and the SOUSY radar, located near the launch site, measured mesospheric turbulence. Electron density irregularities and strong gradients were measured by the rocket probes in the region of most intense backscatter observed by the radar. The electron density profiles (8 to 4 on ascent and 4 on descent) show very different characteristics in the peak scattering region and show marked spatial and temporal variability. These data are intercompared and discussed.

  11. CONFIRMATORY SURVEY RESULTS FOR PORTIONS OF THE ABB COMBUSTION ENGINEERING SITE IN WINDSOR, CONNECTICUT DURING THE FALL OF 2011

    SciTech Connect

    Wade C. Adams

    2011-12-09

    From the mid-1950s until mid-2000, the Combustion Engineering, Inc. (CE) site in Windsor, Connecticut (Figure A-1) was involved in the research, development, engineering, production, and servicing of nuclear fuels, systems, and services. The site is currently undergoing decommissioning that will lead to license termination and unrestricted release in accordance with the requirements of the License Termination Rule in 10 CFR Part 20, Subpart E. Asea Brown Boveri Incorporated (ABB) has been decommissioning the CE site since 2001.

  12. "CONFIRMATORY SURVEY RESULTS FOR THE ABB COMBUSTION ENGINEERING SITE WINDSOR, CONNECTICUT DCN 5158-SR-02-2

    SciTech Connect

    ADAMS, WADE C

    2013-03-25

    The objectives of the confirmatory activities were to provide independent contractor field data reviews and to generate independent radiological data for use by the NRC in evaluating the adequacy and accuracy of the contractor's procedures and FSS results. ORAU reviewed ABB CE's decommissioning plan, final status survey plan, and the applicable soil DCGLs, which were developed based on an NRC-approved radiation dose assessment. The surveys include gamma surface scans, gamma direct measurements, and soil sampling.

  13. Drop Test Results for the Combustion Engineering Model No. ABB-2901 Fuel Pellet Package

    SciTech Connect

    Hafner, R S; Mok, G C; Hagler, L G

    2004-04-23

    The U.S. Nuclear Regulatory Commission (USNRC) contracted with the Packaging Review Group (PRG) at Lawrence Livermore National Laboratory (LLNL) to conduct a single, 30-ft shallow-angle drop test on the Combustion Engineering ABB-2901 drum-type shipping package. The purpose of the test was to determine if bolted-ring drum closures could fail during shallow-angle drops. The PRG at LLNL planned the test, and Defense Technologies Engineering Division (DTED) personnel from LLNL's Site-300 Test Group executed the plan. The test was conducted in November 2001 using the drop-tower facility at LLNL's Site 300. Two representatives from Westinghouse Electric Company in Columbia, South Carolina (WEC-SC); two USNRC staff members; and three PRG members from LLNL witnessed the preliminary test runs and the final test. The single test clearly demonstrated the vulnerability of the bolted-ring drum closure to shallow-angle drops-the test package's drum closure was easily and totally separated from the drum package. The results of the preliminary test runs and the 30-ft shallow-angle drop test offer valuable qualitative understandings of the shallow-angle impact.

  14. Piping benchmark problems for the ABB/CE System 80+ Standardized Plant

    SciTech Connect

    Bezler, P.; DeGrassi, G.; Braverman, J.; Wang, Y.K.

    1994-07-01

    To satisfy the need for verification of the computer programs and modeling techniques that will be used to perform the final piping analyses for the ABB/Combustion Engineering System 80+ Standardized Plant, three benchmark problems were developed. The problems are representative piping systems subjected to representative dynamic loads with solutions developed using the methods being proposed for analysis for the System 80+ standard design. It will be required that the combined license licensees demonstrate that their solution to these problems are in agreement with the benchmark problem set. The first System 80+ piping benchmark is a uniform support motion response spectrum solution for one section of the feedwater piping subjected to safe shutdown seismic loads. The second System 80+ piping benchmark is a time history solution for the feedwater piping subjected to the transient loading induced by a water hammer. The third System 80+ piping benchmark is a time history solution of the pressurizer surge line subjected to the accelerations induced by a main steam line pipe break. The System 80+ reactor is an advanced PWR type.

  15. Comparable application of the OCT and Abbe refractometers for measurements of glycated hemoglobin portion in blood

    NASA Astrophysics Data System (ADS)

    Zhernovaya, Olga S.; Tuchin, Valery V.; Wang, Ruikang K.

    2006-02-01

    It is known that glucose interacts with plasma proteins and hemoglobin in erythrocytes. Glycated (glycosylated) hemoglobin is the result of an irreversible non-enzymatic fixation of glucose on the beta chain of hemoglobin A. The amount of glycated hemoglobin depends on blood glucose concentration and reflects the mean glycemia of about the previous 2-3 months. Glycated hemoglobin is a useful marker for long-term glucose control in diabetic patients. Therefore, the search of quick and high sensitive methods for measurement of glycated hemoglobin portion in blood is important. This study is focused on the determination of refractive index of hemoglobin solution at different glucose concentrations. Measurements were performed using Abbe refractometer at 589 nm and optical coherence tomography (OCT) at 820 nm. The different amount of glucose (from 0 to 1000 mg/dl with a step 100 mg/dl) was added to hemoglobin solution. Theoretical values of refractive index of hemoglobin solutions with glucose were calculated supposing non-interacting hemoglobin and glucose molecules. There is a difference between measured and calculated values of refractive index. This difference is due to glucose binding to hemoglobin. It is shown that the refractive index measurements can be applied for the evaluation of glycated hemoglobin amount.

  16. Selective inhibitors of nuclear export (SINE) as novel therapeutics for prostate cancer.

    PubMed

    Mendonca, Janet; Sharma, Anup; Kim, Hae-Soo; Hammers, Hans; Meeker, Alan; De Marzo, Angelo; Carducci, Michael; Kauffman, Michael; Shacham, Sharon; Kachhap, Sushant

    2014-08-15

    Mislocalization of proteins is a common feature of cancer cells. Since localization of proteins is tightly linked to its function, cancer cells can inactivate function of a tumor suppressor protein through mislocalization. The nuclear exportin CRM1/XPO 1 is upregulated in many cancers. Targeting XPO 1 can lead to nuclear retention of cargo proteins such as p53, Foxo, and BRCA1 leading to cell cycle arrest and apoptosis. We demonstrate that selective inhibitors of nuclear export (SINE) can functionally inactivate XPO 1 in prostate cancer cells. Unlike the potent, but toxic, XPO 1 inhibitor leptomycin B, SINE inhibitors (KPT-185, KPT-330, and KPT-251) cause a decrease in XPO 1 protein level through the proteasomal pathway. Treatment of prostate cancer cells with SINE inhibitors lead to XPO 1 inhibition, as evaluated by RevGFP export assay, leading to nuclear retention of p53 and Foxo proteins, consequently, triggering apoptosis. Our data reveal that treatment with SINE inhibitors at nanomolar concentrations results in decrease in proliferation and colonogenic capacity of prostate cancer cells by triggering apoptosis without causing any cell cycle arrest. We further demonstrate that SINE inhibitors can be combined with other chemotherapeutics like doxorubicin to achieve enhanced growth inhibition of prostate cancer cells. Since SINE inhibitors offer increased bioavailability, reduced toxicity to normal cells, and are orally available they can serve as effective therapeutics against prostate cancer. In conclusion, our data reveals that nucleocytoplasmic transport in prostate cancer can be effectively targeted by SINE inhibitors.

  17. Core-SINE blocks comprise a large fraction of monotreme genomes; implications for vertebrate chromosome evolution.

    PubMed

    Kirby, Patrick J; Greaves, Ian K; Koina, Edda; Waters, Paul D; Marshall Graves, Jennifer A

    2007-01-01

    The genomes of the egg-laying platypus and echidna are of particular interest because monotremes are the most basal mammal group. The chromosomal distribution of an ancient family of short interspersed repeats (SINEs), the core-SINEs, was investigated to better understand monotreme genome organization and evolution. Previous studies have identified the core-SINE as the predominant SINE in the platypus genome, and in this study we quantified, characterized and localized subfamilies. Dot blot analysis suggested that a very large fraction (32% of the platypus and 16% of the echidna genome) is composed of Mon core-SINEs. Core-SINE-specific primers were used to amplify PCR products from platypus and echidna genomic DNA. Sequence analysis suggests a common consensus sequence Mon 1-B, shared by platypus and echidna, as well as platypus-specific Mon 1-C and echidna specific Mon 1-D consensus sequences. FISH mapping of the Mon core-SINE products to platypus metaphase spreads demonstrates that the Mon-1C subfamily is responsible for the striking Mon core-SINE accumulation in the distal regions of the six large autosomal pairs and the largest X chromosome. This unusual distribution highlights the dichotomy between the seven large chromosome pairs and the 19 smaller pairs in the monotreme karyotype, which has some similarity to the macro- and micro-chromosomes of birds and reptiles, and suggests that accumulation of repetitive sequences may have enlarged small chromosomes in an ancestral vertebrate. In the forthcoming sequence of the platypus genome there are still large gaps, and the extensive Mon core-SINE accumulation on the distal regions of the six large autosomal pairs may provide one explanation for this missing sequence. PMID:18185983

  18. A new nano-accuracy AFM system for minimizing Abbe errors and the evaluation of its measuring uncertainty.

    PubMed

    Kim, Dongmin; Lee, Dong Yeon; Gweon, Dae Gab

    2007-01-01

    A new AFM system was designed for the establishment of a standard technique of nano-length measurement in a 2D plane. In a long range (about several tens of micrometers), measurement uncertainty is dominantly affected by the Abbe error of the XY scanning stage. No linear stage is perfectly straight; in other words, every scanning stage is subject to tilting, pitch and yaw motions. In this paper, an AFM system with minimum offsets of XY sensing is designed. Moreover, the XY scanning stage is designed to minimize the rotation angle, as Abbe errors occur through multiple combination of the offset and the rotation angle. To minimize the rotation angle, an optimal design is performed by maximizing the ratio of the stiffness of the parasitic direction to the motion direction of each stage. This paper describes a design scheme of a full AFM system, in particular, the XY scanner. The full range of a fabricated XY scanner is 100 microm x 100 microm. The tilting, pitch and yaw motions are measured by an autocollimator to evaluate the performance of the XY stage. The results show that the XY scanner have a 0.75 arcsec parasitic rotation about the maximum range, thus the uncertainty in terms of the Abbe errors are very small relative to other standard equipment. Using this AFM system, a 3mum pitch specimen was measured. The measurement uncertainty of the total system was evaluated especially about pitch length. For a 1D evaluation, Abbe errors are the most dominant factor, and the expanded combined uncertainty (k = 2) of system was square root (4.13)(2)+(5.07 x 10(-5)xp)(2)(nm). For a 2D evaluation, mirror non-orthogonality and Abbe errors are dominant factors, and expanded combined uncertainty (k = 2) of the system was square root (4.13)(2)+(1.228 x 10(-4)xp)(2) in the X direction, and square root (6.28)(2)+(1.266 x 10(-4)xp)(2) in the Y direction (the unit is nanometers), where p is the measured length in nm.

  19. Occurrence of Can-SINEs and intron sequence evolution supports robust phylogeny of pinniped carnivores and their terrestrial relatives.

    PubMed

    Schröder, Christiane; Bleidorn, Christoph; Hartmann, Stefanie; Tiedemann, Ralph

    2009-12-15

    Investigating the dog genome we found 178965 introns with a moderate length of 200-1000 bp. A screening of these sequences against 23 different repeat libraries to find insertions of short interspersed elements (SINEs) detected 45276 SINEs. Virtually all of these SINEs (98%) belong to the tRNA-derived Can-SINE family. Can-SINEs arose about 55 million years ago before Carnivora split into two basal groups, the Caniformia (dog-like carnivores) and the Feliformia (cat-like carnivores). Genome comparisons of dog and cat recovered 506 putatively informative SINE loci for caniformian phylogeny. In this study we show how to use such genome information of model organisms to research the phylogeny of related non-model species of interest. Investigating a dataset including representatives of all major caniformian lineages, we analysed 24 randomly chosen loci for 22 taxa. All loci were amplifiable and revealed 17 parsimony-informative SINE insertions. The screening for informative SINE insertions yields a large amount of sequence information, in particular of introns, which contain reliable phylogenetic information as well. A phylogenetic analysis of intron- and SINE sequence data provided a statistically robust phylogeny which is congruent with the absence/presence pattern of our SINE markers. This phylogeny strongly supports a sistergroup relationship of Musteloidea and Pinnipedia. Within Pinnipedia, we see strong support from bootstrapping and the presence of a SINE insertion for a sistergroup relationship of the walrus with the Otariidae. PMID:19563867

  20. Occurrence of Can-SINEs and intron sequence evolution supports robust phylogeny of pinniped carnivores and their terrestrial relatives.

    PubMed

    Schröder, Christiane; Bleidorn, Christoph; Hartmann, Stefanie; Tiedemann, Ralph

    2009-12-15

    Investigating the dog genome we found 178965 introns with a moderate length of 200-1000 bp. A screening of these sequences against 23 different repeat libraries to find insertions of short interspersed elements (SINEs) detected 45276 SINEs. Virtually all of these SINEs (98%) belong to the tRNA-derived Can-SINE family. Can-SINEs arose about 55 million years ago before Carnivora split into two basal groups, the Caniformia (dog-like carnivores) and the Feliformia (cat-like carnivores). Genome comparisons of dog and cat recovered 506 putatively informative SINE loci for caniformian phylogeny. In this study we show how to use such genome information of model organisms to research the phylogeny of related non-model species of interest. Investigating a dataset including representatives of all major caniformian lineages, we analysed 24 randomly chosen loci for 22 taxa. All loci were amplifiable and revealed 17 parsimony-informative SINE insertions. The screening for informative SINE insertions yields a large amount of sequence information, in particular of introns, which contain reliable phylogenetic information as well. A phylogenetic analysis of intron- and SINE sequence data provided a statistically robust phylogeny which is congruent with the absence/presence pattern of our SINE markers. This phylogeny strongly supports a sistergroup relationship of Musteloidea and Pinnipedia. Within Pinnipedia, we see strong support from bootstrapping and the presence of a SINE insertion for a sistergroup relationship of the walrus with the Otariidae.

  1. Evolution of SINE S1 retroposons in Cruciferae plant species.

    PubMed

    Lenoir, A; Cournoyer, B; Warwick, S; Picard, G; Deragon, J M

    1997-09-01

    The S1 element is a plant short interspersed element (SINE) that was first described and studied in Brassica napus. In this work, we investigated the distribution and the molecular phylogeny of the S1 element within the Cruciferae (= Brassicaceae). S1 elements were found to be widely distributed within the Cruciferae, especially in species of the tribe Brassiceae. The molecular phylogeny of S1 elements in eight Cruciferae species (Brassica oleracea, Brassica rapa, Brassica napus, Brassica nigra, Sinapis, arvensis, Sinapis pubescens, Coincya monensis, and Vella spinosa) was inferred using 14-36 elements per species. Significant neighbor-joining and maximum-parsimony phylogenetic clusters, supported by high bootstrap P values and/or represented in 100% of the most-parsimonious trees, were observed for each species. Most of these clusters probably correspond to recent species-specific bursts of S1 amplification. Since these species diverged recently, S1 amplification in Cruciferae plants is proposed to be a highly dynamic process that could contribute to genome rearrangements and eventually lead to reproductive isolation. S1 sequence analysis also revealed putative gene conversion events that occurred between different S1 elements of a given species. These events suggest that gene conversion is a minor but significant component of the molecular drive governing S1 concerted evolution.

  2. LINE-1 ORF1 protein enhances Alu SINE retrotransposition.

    PubMed

    Wallace, Nicholas; Wagstaff, Bradley J; Deininger, Prescott L; Roy-Engel, Astrid M

    2008-08-01

    Retroelements have contributed over one third of the human genome mass. The currently active LINE-1 (L1) codes for two proteins (ORF1p and ORF2p), both strictly required for retrotransposition. In contrast, the non-coding parasitic SINE (Alu) only appears to need the L1 ORF2p for its own amplification. This requirement was previously determined using a tissue culture assay system in human cells (HeLa). Because HeLa are likely to express functional L1 proteins, it is possible that low levels of endogenous ORF1p are necessary for the observed tagged Alu mobilization. By individually expressing ORF1 and ORF2 proteins from both human (L1RP and LRE3) and rodent (L1A102 and L1spa) L1 sources, we demonstrate that increasing amounts of ORF1 expressing vector enhances tagged Alu mobilization in HeLa cells. In addition, using chicken fibroblast cells as an alternate cell culture source, we confirmed that ORF1p is not strictly required for Alu mobilization in our assay. Supporting our observations in HeLa cells, we find that tagged Alu retrotransposition is improved by supplementation of ORF1p in the cultured chicken cells. We postulate that L1 ORF1p plays either a direct or indirect role in enhancing the interaction between the Alu RNA and the required factors needed for its retrotransposition.

  3. Perish, then publish: Thomas Harriot and the sine law of refraction.

    PubMed

    Fishman, R S

    2000-03-01

    A talented young scientist, Thomas Harriot, wrote the first English account of the New World, "A Briefe and True Report of the New Found Land of Virginia," distinguished by its serious effort to describe and understand the American Indian. Harriot went on to make innovations in mathematics and was one of the first astronomers to use the telescope. His largely unappreciated contribution to the history of ophthalmology was the first formulation of the sine law of refraction of light, found in his unpublished papers long after his death in 1621. Willebrord Snell discovered the sine law in Holland in 1621 but also died without formally publishing it. Rene Descartes first published the sine law in 1637. The sine law of refraction became not only the prime law of all lens systems but ushered in a new world of physical laws.

  4. Analog circuit for the measurement of phase difference between two noisy sine-wave signals

    SciTech Connect

    Shakkottai, P.; Kwack, E.Y.; Back, L.H. )

    1989-09-01

    A simple circuit for the measurement of phase difference between two noisy sine waves is described. The circuit locks over a wide range of frequencies and produces an output proportional to the phase difference of signals that vary rather rapidly.

  5. Sine Rotation Vector Method for Attitude Estimation of an Underwater Robot

    PubMed Central

    Ko, Nak Yong; Jeong, Seokki; Bae, Youngchul

    2016-01-01

    This paper describes a method for estimating the attitude of an underwater robot. The method employs a new concept of sine rotation vector and uses both an attitude heading and reference system (AHRS) and a Doppler velocity log (DVL) for the purpose of measurement. First, the acceleration and magnetic-field measurements are transformed into sine rotation vectors and combined. The combined sine rotation vector is then transformed into the differences between the Euler angles of the measured attitude and the predicted attitude; the differences are used to correct the predicted attitude. The method was evaluated according to field-test data and simulation data and compared to existing methods that calculate angular differences directly without a preceding sine rotation vector transformation. The comparison verifies that the proposed method improves the attitude estimation performance. PMID:27490549

  6. Sine Rotation Vector Method for Attitude Estimation of an Underwater Robot.

    PubMed

    Ko, Nak Yong; Jeong, Seokki; Bae, Youngchul

    2016-08-02

    This paper describes a method for estimating the attitude of an underwater robot. The method employs a new concept of sine rotation vector and uses both an attitude heading and reference system (AHRS) and a Doppler velocity log (DVL) for the purpose of measurement. First, the acceleration and magnetic-field measurements are transformed into sine rotation vectors and combined. The combined sine rotation vector is then transformed into the differences between the Euler angles of the measured attitude and the predicted attitude; the differences are used to correct the predicted attitude. The method was evaluated according to field-test data and simulation data and compared to existing methods that calculate angular differences directly without a preceding sine rotation vector transformation. The comparison verifies that the proposed method improves the attitude estimation performance.

  7. Sine Rotation Vector Method for Attitude Estimation of an Underwater Robot.

    PubMed

    Ko, Nak Yong; Jeong, Seokki; Bae, Youngchul

    2016-01-01

    This paper describes a method for estimating the attitude of an underwater robot. The method employs a new concept of sine rotation vector and uses both an attitude heading and reference system (AHRS) and a Doppler velocity log (DVL) for the purpose of measurement. First, the acceleration and magnetic-field measurements are transformed into sine rotation vectors and combined. The combined sine rotation vector is then transformed into the differences between the Euler angles of the measured attitude and the predicted attitude; the differences are used to correct the predicted attitude. The method was evaluated according to field-test data and simulation data and compared to existing methods that calculate angular differences directly without a preceding sine rotation vector transformation. The comparison verifies that the proposed method improves the attitude estimation performance. PMID:27490549

  8. Binding of TFIIIC to SINE Elements Controls the Relocation of Activity-Dependent Neuronal Genes to Transcription Factories

    PubMed Central

    Crepaldi, Luca; Policarpi, Cristina; Coatti, Alessandro; Sherlock, William T.; Jongbloets, Bart C.; Down, Thomas A.; Riccio, Antonella

    2013-01-01

    In neurons, the timely and accurate expression of genes in response to synaptic activity relies on the interplay between epigenetic modifications of histones, recruitment of regulatory proteins to chromatin and changes to nuclear structure. To identify genes and regulatory elements responsive to synaptic activation in vivo, we performed a genome-wide ChIPseq analysis of acetylated histone H3 using somatosensory cortex of mice exposed to novel enriched environmental (NEE) conditions. We discovered that Short Interspersed Elements (SINEs) located distal to promoters of activity-dependent genes became acetylated following exposure to NEE and were bound by the general transcription factor TFIIIC. Importantly, under depolarizing conditions, inducible genes relocated to transcription factories (TFs), and this event was controlled by TFIIIC. Silencing of the TFIIIC subunit Gtf3c5 in non-stimulated neurons induced uncontrolled relocation to TFs and transcription of activity-dependent genes. Remarkably, in cortical neurons, silencing of Gtf3c5 mimicked the effects of chronic depolarization, inducing a dramatic increase of both dendritic length and branching. These findings reveal a novel and essential regulatory function of both SINEs and TFIIIC in mediating gene relocation and transcription. They also suggest that TFIIIC may regulate the rearrangement of nuclear architecture, allowing the coordinated expression of activity-dependent neuronal genes. PMID:23966877

  9. Transposable B2 SINE elements can provide mobile RNA polymerase II promoters.

    PubMed

    Ferrigno, O; Virolle, T; Djabari, Z; Ortonne, J P; White, R J; Aberdam, D

    2001-05-01

    Short interspersed elements (SINEs) are highly abundant components of mammalian genomes that are propagated by retrotransposition. SINEs are recognized as a causal agent of human disease and must also have had a profound influence in shaping eukaryotic genomes. The B2 SINE family constitutes approximately 0.7% of total mouse genomic DNA (ref. 2) and is also found at low abundance in humans. It resembles the Alu family in several respects, such as its mechanism of propagation. B2 SINEs are derived from tRNA and are transcribed by RNA polymerase (pol) III to generate short transcripts that are not translated. We find here, however, that one B2 SINE also carries an active pol II promoter located outside the tRNA region. Indeed, a B2 element is responsible for the production of a mouse Lama3 transcript. The B2 pol II promoters can be bound and stimulated by the transcription factor USF (for upstream stimulatory factor), as shown by transient transfection experiments. Moreover, this pol II activity does not preclude the pol III transcription necessary for retrotransposition. Dispersal of B2 SINEs by retrotransposition may therefore have provided numerous opportunities for creating regulated pol II transcription at novel genomic sites. This mechanism may have allowed the evolution of new transcription units and new genes. PMID:11326281

  10. A New Class of SINEs with snRNA Gene-Derived Heads

    PubMed Central

    Kojima, Kenji K.

    2015-01-01

    Eukaryotic genomes are colonized by various transposons including short interspersed elements (SINEs). The 5′ region (head) of the majority of SINEs is derived from one of the three types of RNA genes—7SL RNA, transfer RNA (tRNA), or 5S ribosomal RNA (rRNA)—and the internal promoter inside the head promotes the transcription of the entire SINEs. Here I report a new group of SINEs whose heads originate from either the U1 or U2 small nuclear RNA gene. These SINEs, named SINEU, are distributed among crocodilians and classified into three families. The structures of the SINEU-1 subfamilies indicate the recurrent addition of a U1- or U2-derived sequence onto the 5′ end of SINEU-1 elements. SINEU-1 and SINEU-3 are ancient and shared among alligators, crocodiles, and gharials, while SINEU-2 is absent in the alligator genome. SINEU-2 is the only SINE family that was active after the split of crocodiles and gharials. All SINEU families, especially SINEU-3, are preferentially inserted into a family of Mariner DNA transposon, Mariner-N4_AMi. A group of Tx1 non-long terminal repeat retrotransposons designated Tx1-Mar also show target preference for Mariner-N4_AMi, indicating that SINEU was mobilized by Tx1-Mar. PMID:26019167

  11. A New Class of SINEs with snRNA Gene-Derived Heads.

    PubMed

    Kojima, Kenji K

    2015-05-27

    Eukaryotic genomes are colonized by various transposons including short interspersed elements (SINEs). The 5' region (head) of the majority of SINEs is derived from one of the three types of RNA genes--7SL RNA, transfer RNA (tRNA), or 5S ribosomal RNA (rRNA)--and the internal promoter inside the head promotes the transcription of the entire SINEs. Here I report a new group of SINEs whose heads originate from either the U1 or U2 small nuclear RNA gene. These SINEs, named SINEU, are distributed among crocodilians and classified into three families. The structures of the SINEU-1 subfamilies indicate the recurrent addition of a U1- or U2-derived sequence onto the 5' end of SINEU-1 elements. SINEU-1 and SINEU-3 are ancient and shared among alligators, crocodiles, and gharials, while SINEU-2 is absent in the alligator genome. SINEU-2 is the only SINE family that was active after the split of crocodiles and gharials. All SINEU families, especially SINEU-3, are preferentially inserted into a family of Mariner DNA transposon, Mariner-N4_AMi. A group of Tx1 non-long terminal repeat retrotransposons designated Tx1-Mar also show target preference for Mariner-N4_AMi, indicating that SINEU was mobilized by Tx1-Mar.

  12. A New Class of SINEs with snRNA Gene-Derived Heads.

    PubMed

    Kojima, Kenji K

    2015-06-01

    Eukaryotic genomes are colonized by various transposons including short interspersed elements (SINEs). The 5' region (head) of the majority of SINEs is derived from one of the three types of RNA genes--7SL RNA, transfer RNA (tRNA), or 5S ribosomal RNA (rRNA)--and the internal promoter inside the head promotes the transcription of the entire SINEs. Here I report a new group of SINEs whose heads originate from either the U1 or U2 small nuclear RNA gene. These SINEs, named SINEU, are distributed among crocodilians and classified into three families. The structures of the SINEU-1 subfamilies indicate the recurrent addition of a U1- or U2-derived sequence onto the 5' end of SINEU-1 elements. SINEU-1 and SINEU-3 are ancient and shared among alligators, crocodiles, and gharials, while SINEU-2 is absent in the alligator genome. SINEU-2 is the only SINE family that was active after the split of crocodiles and gharials. All SINEU families, especially SINEU-3, are preferentially inserted into a family of Mariner DNA transposon, Mariner-N4_AMi. A group of Tx1 non-long terminal repeat retrotransposons designated Tx1-Mar also show target preference for Mariner-N4_AMi, indicating that SINEU was mobilized by Tx1-Mar. PMID:26019167

  13. Sine-wave and noise-vocoded sine-wave speech in a tone language: Acoustic details matter.

    PubMed

    Rosen, Stuart; Hui, Sze Ngar Catherine

    2015-12-01

    Sine-wave speech (SWS) is a highly simplified version of speech consisting only of frequency- and amplitude-modulated sinusoids representing the formants. That listeners can successfully understand SWS has led to claims that speech perception must be based on abstract properties of the stimuli far removed from their specific acoustic form. Here it is shown, in bilingual Cantonese/English listeners, that performance with Cantonese SWS is improved by noise vocoding, with no effect on English SWS utterances. This manipulation preserves the abstract informational structure in the signals but changes its surface form. The differential effects of noise vocoding likely arise from the fact that Cantonese is a tonal language and hence more reliant on fundamental frequency (F0) contours for its intelligibility. SWS does not preserve tonal information from the original speech but does have false tonal information signalled by the lowest frequency sinusoid. Noise vocoding SWS appears to minimise the tonal percept, which thus interferes less in the perception of Cantonese. It has no effect in English, which is minimally reliant on F0 variations for intelligibility. Therefore it is not only the informational structure of a sound that is important but also how its acoustic detail interacts with the phonological structure of a given language.

  14. Sine-wave and noise-vocoded sine-wave speech in a tone language: Acoustic details matter.

    PubMed

    Rosen, Stuart; Hui, Sze Ngar Catherine

    2015-12-01

    Sine-wave speech (SWS) is a highly simplified version of speech consisting only of frequency- and amplitude-modulated sinusoids representing the formants. That listeners can successfully understand SWS has led to claims that speech perception must be based on abstract properties of the stimuli far removed from their specific acoustic form. Here it is shown, in bilingual Cantonese/English listeners, that performance with Cantonese SWS is improved by noise vocoding, with no effect on English SWS utterances. This manipulation preserves the abstract informational structure in the signals but changes its surface form. The differential effects of noise vocoding likely arise from the fact that Cantonese is a tonal language and hence more reliant on fundamental frequency (F0) contours for its intelligibility. SWS does not preserve tonal information from the original speech but does have false tonal information signalled by the lowest frequency sinusoid. Noise vocoding SWS appears to minimise the tonal percept, which thus interferes less in the perception of Cantonese. It has no effect in English, which is minimally reliant on F0 variations for intelligibility. Therefore it is not only the informational structure of a sound that is important but also how its acoustic detail interacts with the phonological structure of a given language. PMID:26723325

  15. Audio-visual integration of speech with time-varying sine wave speech replicas

    NASA Astrophysics Data System (ADS)

    Tuomainen, Jyrki; Andersen, Tobias; Tiippana, Kaisa; Sams, Mikko

    2002-11-01

    We tested whether listener's knowledge about the nature of the auditory stimuli had an effect on audio-visual (AV) integration of speech. First, subjects were taught to categorize two sine-wave (sw) replicas of the real speech tokens /omso/ and /onso/ into two arbitrary nonspeech categories without knowledge of the speech-like nature of the sounds. A test with congruent and incongruent AV-stimulus condition (together with auditory-only presentations of the sw stimuli) demonstrated no AV integration, but instead close to perfect categorization of stimuli in the two arbitrary categories according to the auditory presentation channel. Then, the same subjects (of which most were still under the impression that the sw-stimuli were nonspeech sounds) were taught to categorize the sw stimuli as /omso/ and /onso/, and again tested with the same AV stimuli as used in the nonspeech sw condition. This time, subjects showed highly reliable AV integration similar to integration obtained with real speech stimuli in a separate test. We suggest that AV integration only occurs when subject are in a so-called ''speech mode.''

  16. Short interspersed elements (SINEs) of squamate reptiles (Squam1 and Squam2): structure and phylogenetic significance.

    PubMed

    Grechko, Vernata V; Kosushkin, Sergei A; Borodulina, Olga R; Butaeva, Fatima G; Darevsky, Ilya S

    2011-05-15

    Short interspersed elements (SINEs) are important nuclear molecular markers of the evolution of many eukaryotes. However, the SINEs of squamate reptile genomes have been little studied. We first identified two families of SINEs, termed Squam1 and Squam2, in the DNA of meadow lizard Darevskia praticola (Lacertidae) by performing DNA hybridization and PCR. Later, the same families of retrotransposons were found using the same methods in members of another 25 lizard families (from Iguania, Scincomorpha, Gekkota, Varanoidea, and Diploglossa infraorders) and two snake families, but their abundances in these taxa varied greatly. Both SINEs were Squamata-specific and were absent from mammals, birds, crocodiles, turtles, amphibians, and fish. Squam1 possessed some characteristics common to tRNA-related SINEs from fish and mammals, while Squam2 belonged to the tRNA(Ala) group of SINEs and had a more unusual and divergent structure. Squam2-related sequences were found in several unannotated GenBank sequences of squamate reptiles. Squam1 abundance in the Polychrotidae, Agamidae, Leiolepididae, Chamaeleonidae, Scincidae, Lacertidae, Gekkonidae, Varanidae, Helodermatidae, and two snake families were 10(2) -10(4) times higher than those in other taxa (Corytophanidae, Iguanidae, Anguidae, Cordylidae, Gerrhosauridae, Pygopodidae, and Eublepharidae). A less dramatic degree of copy number variation was observed for Squam2 in different taxa. Several Squam1 copies from Lacertidae, Chamaeleonidae, Gekkonidae, Varanidae, and Colubridae were sequenced and found to have evident orthologous features, as well as taxa-specific autapomorphies. Squam1 from Lacertidae and Chamaeleonidae could be divided into several subgroups based on sequence differences. Possible applications of these SINEs as Squamata phylogeny markers are discussed. PMID:21462315

  17. Optimal design of a flexure hinge-based XYZ atomic force microscopy scanner for minimizing Abbe errors

    SciTech Connect

    Kim, Dongmin; Kang, Dongwoo; Shim, Jongyeop; Song, Incheon; Gweon, Daegab

    2005-07-15

    To establish of standard technique of nanolength measurement in a two-dimensional plane, a new (AFM) system has been designed. In this system, measurement uncertainty is dominantly affected by the Abbe error of the XYZ scanning stage. No linear stage is perfectly straight; in other words, every scanning stage is subject to tilting, pitch, and yaw motion. In this article, an AFM system with minimum offset of XYZ sensing is designed. And, the XYZ scanning stage is designed to minimize the rotation angle because Abbe errors occur through the multiply of offset and rotation angle. For XY stage, optimal design is performed to minimize the rotation angle by maximizing the stiffness ratio of motion direction to the parasitic motion direction of each stage. For the Z stage, the optimal design of maximizing the first-resonant frequency is performed. When the resonant frequency increases, the scan speed is improved, thereby reducing errors caused by sensor drift. This article describes the procedures of selecting parameters for the optimal design. The full range of the XYZ scanner is 100 {mu}mx100 {mu}mx10 {mu}m. Based on the solution of the optimization problem, the XYZ scanner is fabricated. And tilting, pitch, and yaw motion are measured by autocollimator to evaluate the performance of XY stage.

  18. What happens to linear properties as we move from the Klein-Gordon equation to the sine-Gordon equation

    SciTech Connect

    Kovalyov, Mikhail

    2010-06-15

    In this article the sets of solutions of the sine-Gordon equation and its linearization the Klein-Gordon equation are discussed and compared. It is shown that the set of solutions of the sine-Gordon equation possesses a richer structure which partly disappears during linearization. Just like the solutions of the Klein-Gordon equation satisfy the linear superposition principle, the solutions of the sine-Gordon equation satisfy a nonlinear superposition principle.

  19. Investigation into untripped rollover of light vehicles in the modified fishhook and the sine manoeuvres, part II: effects of vehicle inertia property, suspension and tyre characteristics

    NASA Astrophysics Data System (ADS)

    Dong, Guang-Ming; Zhang, Nong; Du, Hai-Ping

    2011-06-01

    In this paper, as a continuation of part I of [N. Zhang, G.M. Dong, and H.P. Du, Investigation into untripped rollover of light vehicles in the modified fishhook and the sine manoeuvres, part I: vehicle modelling, roll and yaw instability, Veh. Syst. Dyn. 46 (2008), pp. 271-293], detailed parametric studies are conducted and compared between the fishhook and sine manoeuvres using the presented nine-degree-of-freedom vehicle model, in order to understand the rollover resistance capability of a light passenger vehicle with various parameters. First, effects of driving conditions are studied in the two manoeuvres. Secondly, effects of suspension characteristics are studied, in which the influence of suspension spring stiffness and shock absorber damping, anti-roll bar is discussed. Thirdly, effects of vehicle inertia properties, such as moment of inertia of vehicle sprung mass, sprung mass weight and location of centre of gravity, are investigated. Finally, effects of tyre characteristics are also investigated by altering the scaling factor λ Fz0. An in-depth understanding has been gained on the significant effects of key system parameters on the kinetic performance of vehicles under the fishhook and the sine manoeuvres. Parametric studies show that the combination of step input (fishhook) and frequency input gives a clear indication of the vehicle dynamic stability during cornering.

  20. Development and application of SINE multilocus and quantitative genetic markers to study oilseed rape (Brassica napus L.) crops.

    PubMed

    Allnutt, T R; Roper, K; Henry, C

    2008-01-23

    A genetic marker system based on the S1 Short Interspersed Elements (SINEs) in the important commercial crop, oilseed rape ( Brassica napus L.) has been developed. SINEs provided a successful multilocus, dominant marker system that was capable of clearly delineating winter- and spring-type crop varieties. Sixteen of 20 varieties tested showed unique profiles from the 17 polymorphic SINE markers generated. The 3' or 5' flank region of nine SINE markers were cloned, and DNA was sequenced. In addition, one putative pre-transposition SINE allele was cloned and sequenced. Two SINE flanking sequences were used to design real-time PCR assays. These quantitative SINE assays were applied to study the genetic structure of eight fields of oilseed rape crops. Studied fields were more genetically diverse than expected for the chosen loci (mean H T = 0.23). The spatial distribution of SINE marker frequencies was highly structured in some fields, suggesting locations of volunteer impurities within the crop. In one case, the assay identified a mislabeling of the crop variety. SINE markers were a useful tool for crop genetics, phylogenetics, variety identification, and purity analysis. The use and further application of quantitative, real-time PCR markers are discussed.

  1. Development and application of SINE multilocus and quantitative genetic markers to study oilseed rape (Brassica napus L.) crops.

    PubMed

    Allnutt, T R; Roper, K; Henry, C

    2008-01-23

    A genetic marker system based on the S1 Short Interspersed Elements (SINEs) in the important commercial crop, oilseed rape ( Brassica napus L.) has been developed. SINEs provided a successful multilocus, dominant marker system that was capable of clearly delineating winter- and spring-type crop varieties. Sixteen of 20 varieties tested showed unique profiles from the 17 polymorphic SINE markers generated. The 3' or 5' flank region of nine SINE markers were cloned, and DNA was sequenced. In addition, one putative pre-transposition SINE allele was cloned and sequenced. Two SINE flanking sequences were used to design real-time PCR assays. These quantitative SINE assays were applied to study the genetic structure of eight fields of oilseed rape crops. Studied fields were more genetically diverse than expected for the chosen loci (mean H T = 0.23). The spatial distribution of SINE marker frequencies was highly structured in some fields, suggesting locations of volunteer impurities within the crop. In one case, the assay identified a mislabeling of the crop variety. SINE markers were a useful tool for crop genetics, phylogenetics, variety identification, and purity analysis. The use and further application of quantitative, real-time PCR markers are discussed. PMID:18092752

  2. SINE extinction preceded LINE extinction in sigmodontine rodents: implications for retrotranspositional dynamics and mechanisms.

    PubMed

    Rinehart, T A; Grahn, R A; Wichman, H A

    2005-01-01

    Short Interspersed Nuclear Elements, or SINEs, retrotranspose despite lacking protein-coding capability. It has been proposed that SINEs utilize enzymes produced in trans by Long Interspersed Nuclear Elements, or LINEs. Strong support for this hypothesis is found in LINE and SINE pairs that share sequence homology; however, LINEs and SINEs in primates and rodents are only linked by an insertion site motif. We have now profiled L1 LINE and B1 SINE activity in 24 rodent species including candidate taxa for the first documented L1 extinction. As expected, there was no evidence for recent activity of B1s in species that also lack L1 activity. However, B1 silencing appears to have preceded L1 extinction, since B1 activity is also lacking in the genus most closely related to those lacking active L1s despite the presence of active L1s in this genus. A second genus with active L1s but inactive B1s was also identified.

  3. Tropisms of Avena coleoptiles: sine law for gravitropism, exponential law for photogravitropic equilibrium.

    PubMed

    Galland, Paul

    2002-09-01

    The quantitative relation between gravitropism and phototropism was analyzed for light-grown coleoptiles of Avena sativa (L.). With respect to gravitropism the coleoptiles obeyed the sine law. To study the interaction between light and gravity, coleoptiles were inclined at variable angles and irradiated for 7 h with unilateral blue light (466 nm) impinging at right angles relative to the axis of the coleoptile. The phototropic stimulus was applied from the side opposite to the direction of gravitropic bending. The fluence rate that was required to counteract the negative gravitropism increased exponentially with the sine of the inclination angle. To achieve balance, a linear increase in the gravitropic stimulus required compensation by an exponential increase in the counteracting phototropic stimulus. The establishment of photogravitropic equilibrium during continuous unilateral irradiation is thus determined by two different laws: the well-known sine law for gravitropism and a novel exponential law for phototropism described in this work. PMID:12244443

  4. Tropisms in Phycomyces: sine law for gravitropism, exponential law for photogravitropic equilibrium.

    PubMed

    Galland, P; Wallacher, Y; Finger, H; Hannappel, M; Tröster, S; Bold, E; Grolig, F

    2002-04-01

    Sporangiophores of Phycomyces blakesleeanus that are gravitropically stimulated by inclining them relative to the earth's gravitational vector obey the sine law for inclination angles between 0 degrees and 150 degrees. The quantitative relation between gravitropism and phototropism was analyzed for sporangiophores that were kept in balance between opposing gravitational and phototropic stimuli. The gravitropism of inclined sporangiophores was compensated with unilateral light impinging at right angles relative to the axis of the sporangiophore. The fluence rate of unilateral blue light (466 nm) that was required to counteract the negative gravitropism increased exponentially with the sine of the inclination angle of the sporangiophore. The establishment of photogravitropic equilibrium during continuous unilateral irradiation is thus determined by two different laws: the well-known sine law for gravitropism and a novel exponential law of phototropism described in this work. Furthermore, the specific form of the exponential relationship depends on the presence of statoliths (vacuolar protein crystals) and on wavelength. PMID:11941470

  5. Toddlers' comprehension of degraded signals: Noise-vocoded versus sine-wave analogs

    PubMed Central

    Newman, Rochelle S.; Chatterjee, Monita; Morini, Giovanna; Remez, Robert E.

    2015-01-01

    Recent findings suggest that development changes the ability to comprehend degraded speech. Preschool children showed greater difficulties perceiving noise-vocoded speech (a signal that integrates amplitude over broad frequency bands) than sine-wave speech (which maintains the spectral peaks without the spectrum envelope). In contrast, 27-month-old children in the present study could recognize speech with either type of degradation and performed slightly better with eight-channel vocoded speech than with sine-wave speech. This suggests that children's identification performance depends critically on the degree of degradation and that their success in recognizing unfamiliar speech encodings is encouraging overall. PMID:26428832

  6. Toddlers' comprehension of degraded signals: Noise-vocoded versus sine-wave analogs.

    PubMed

    Newman, Rochelle S; Chatterjee, Monita; Morini, Giovanna; Remez, Robert E

    2015-09-01

    Recent findings suggest that development changes the ability to comprehend degraded speech. Preschool children showed greater difficulties perceiving noise-vocoded speech (a signal that integrates amplitude over broad frequency bands) than sine-wave speech (which maintains the spectral peaks without the spectrum envelope). In contrast, 27-month-old children in the present study could recognize speech with either type of degradation and performed slightly better with eight-channel vocoded speech than with sine-wave speech. This suggests that children's identification performance depends critically on the degree of degradation and that their success in recognizing unfamiliar speech encodings is encouraging overall. PMID:26428832

  7. Symmetries and soliton solutions of the Galilean complex Sine-Gordon equation

    NASA Astrophysics Data System (ADS)

    de Melo, G. R.; de Montigny, M.; Pinfold, J.; Tuszynski, J. A.

    2016-03-01

    We discuss a new equation, the Galilean version of the complex Sine-Gordon equation in 1 + 1 dimensions, Ψxx (1 -Ψ* Ψ) + 2 imΨt +Ψ* Ψx2- Ψ(1 -Ψ* Ψ) 2 = 0, derived from its relativistic counterpart via Galilean covariance. We determine its Lie point symmetries, discuss some group-invariant solutions, and examine some soliton solutions. The reduction under Galilean symmetry leads to an equation similar to the stationary Gross-Pitaevskii equation. This work is motivated in part by recent applications of the relativistic complex Sine-Gordon equation to the dynamics of Q-balls.

  8. Sine wave artifact as a means of calibrating structured light systems

    NASA Astrophysics Data System (ADS)

    Harding, Kevin G.

    1999-11-01

    Structured light systems made to provide dense data over full image fields present a unique challenge to the task of calibration. Localized artifacts made for CMM or hard gages are often a poor fit for testing actual 3D performance. This paper considers the use of a sine wave artifact to provide a mapping of a calibration matched to full-field capabilities. The sine wave offers the advantages of a continuous function across the full field, with a well defined and easy to analyze shape. Changes in scale in all dimensions, as well as localized variations can be mapped in clear detail using this method.

  9. Sine-Gordon quantum mechanics on the complex plane and N=2 gauge theory

    SciTech Connect

    He Wei

    2010-05-15

    We study the relation between the N=2 gauge theory in the {Omega} background and the quantized integral system recently proposed by Nekrasov and Shatashvili. We focus on the simplest case, the pure Yang-Mills theory with the SU(2) gauge group and the corresponding sine-Gordon integral model on the complex plane. We analyze the periodic wave function and the corresponding energy spectrum of the sine-Gordon quantum mechanics, and find this model contains information of the low energy effective theory of the gauge theory.

  10. {pi} kinks in the parametrically driven sine-Gordon equation and applications

    SciTech Connect

    Zharnitsky, V.; Mitkov, I.

    1997-07-08

    Parametrically driven sine-Gordon equation with a mean-zero forcing is considered. It is shown that the system is well approximated by the double sine-Gordon equation using the normal form technique. The reduced equation possesses {pi}-kink solutions, which are also observed numerically in the original system. This result is applied to domain walls dynamics in one-dimensional easy-plane ferromagnets. For such system the existence of {pi}-kinks implies the true domain structure in the presence of high-frequency magnetic field.

  11. Placement of the AbbVie PEG-J tube for the treatment of Parkinson's disease in the interventional radiology suite

    PubMed Central

    Montgomery, Mark L.; Miner, Noel K.; Soileau, Michael J.

    2016-01-01

    The primary treatment for Parkinson's disease is dopaminergic stimulation. Although levodopa has historically been administered orally, maintaining a predictable plasma concentration of the drug is challenging. As a result, enteral administration of carbidopa/levodopa (Duopa) has emerged as a promising tool in the treatment of the disease. This requires placement of an enteric catheter, two of which have been approved by the Food and Drug Administration for delivery of Duopa. The approved tubes are placed using the “peroral” or “pull” technique, a method traditionally requiring endoscopy. This technical note describes placement of the AbbVie PEG-J tube by means of the peroral route while utilizing only sonographic and fluoroscopic guidance. After placing an orogastric tube and achieving percutaneous access to the stomach under fluoroscopic visualization, a snare catheter is advanced through the percutaneous access into the stomach. The orogastric tube is engaged with the snare and retracted, bringing the attached snare with it to the mouth. The AbbVie PEG tube is attached to the snare, pulled back down the esophagus and into the stomach before being retracted through the percutaneous access to the skin. Finally, the AbbVie J tube is advanced through the gastrostomy tube into the proximal jejunum and attached with the provided connectors. As demonstrated, the AbbVie PEG-J tube can be placed safely and effectively using a percutaneous image-guided technique without the use of an endoscope. PMID:27695184

  12. Placement of the AbbVie PEG-J tube for the treatment of Parkinson's disease in the interventional radiology suite

    PubMed Central

    Montgomery, Mark L.; Miner, Noel K.; Soileau, Michael J.

    2016-01-01

    The primary treatment for Parkinson's disease is dopaminergic stimulation. Although levodopa has historically been administered orally, maintaining a predictable plasma concentration of the drug is challenging. As a result, enteral administration of carbidopa/levodopa (Duopa) has emerged as a promising tool in the treatment of the disease. This requires placement of an enteric catheter, two of which have been approved by the Food and Drug Administration for delivery of Duopa. The approved tubes are placed using the “peroral” or “pull” technique, a method traditionally requiring endoscopy. This technical note describes placement of the AbbVie PEG-J tube by means of the peroral route while utilizing only sonographic and fluoroscopic guidance. After placing an orogastric tube and achieving percutaneous access to the stomach under fluoroscopic visualization, a snare catheter is advanced through the percutaneous access into the stomach. The orogastric tube is engaged with the snare and retracted, bringing the attached snare with it to the mouth. The AbbVie PEG tube is attached to the snare, pulled back down the esophagus and into the stomach before being retracted through the percutaneous access to the skin. Finally, the AbbVie J tube is advanced through the gastrostomy tube into the proximal jejunum and attached with the provided connectors. As demonstrated, the AbbVie PEG-J tube can be placed safely and effectively using a percutaneous image-guided technique without the use of an endoscope.

  13. SunSine300 AC module. Annual report, July 25, 1995--December 31, 1996

    SciTech Connect

    Russell, M.C.; Handleman, C.K.P.

    1997-08-01

    Under Photovoltaic Manufacturing Technology (PVMaT) 4A1, Ascension Technology (AT) is developing the SunSine300 AC PV module. AT`s goals in this project are to meet Underwriters Laboratory (UL) 1741 requirements, obtain Federal Communications Commission (FCC) Class B verification, complete the AC module system design and development, advance the inverter design, design for manufacture, design for reliability, design for serviceability, and demonstrate commercialization through production and sale of about 100 units. To meet these goals, AT corrected a number of deficiencies identified by UL`s preliminary investigation before proceeding to the full UL investigation; a SunSine300 prototype was tested and found to comply with FCC Class B requirements; AT designed a complete line of balance-of-systems hardware for the SunSine 300; AT`s design and performance advancements include accomplishing a total harmonic distortion drop from 5% to 2%, devising a method to eliminate false detection of zero crossings that could damage the inverter, improving the anti-islanding with the addition of AT`s proprietary ZEBRA technique, and redesigning the enclosure for thermal performance, manufacturability, and UL and FCC approval; performing extensive testing in Phase 2 to discover failure modes and susceptibility to aging; and designing the SunSine300 to be easily and safely serviced. 3 figs., 3 tabs.

  14. Emotional Intelligence: The Sine Qua Non for a Clinical Leadership Toolbox

    ERIC Educational Resources Information Center

    Rao, Paul R.

    2006-01-01

    Over the past decade, it has become increasingly clear that although IQ and technical skills are important, emotional intelligence is the Sine Qua Non of leadership. According to Goleman [Goleman, D. (1998). What makes a leader? "Harvard Business Review," 93-102] "effective leaders are alike in one crucial way: they all have a high degree of…

  15. The Use of the Arc-Sine Transformation in the Analysis of Variance.

    ERIC Educational Resources Information Center

    Milligan, Glenn W.

    1987-01-01

    The use of the arc-sine transformation in analysis of variance can lead to difficult inference situations and pose problems in interpretation. It can also produce tests of noticeably lower power when the null hypothesis is false, and is not recommended as a standard tool. Simulated illustrations are provided. (Author/GDC)

  16. Spectral averaging of small-amplitude sine-Gordon wave trains

    NASA Astrophysics Data System (ADS)

    Larson, J. W.; Tracy, E. R.

    1988-11-01

    It is well known that the nonlinear Schrödinger equation is the generic envelope description of nonlinear wave trains in the small-amplitude limit. V. E. Zakharov and E. A. Kuznetsov [Physica 18D, 455 (1986)] have shown that for many systems integrable via inverse-scattering techniques it is possible, through the use of multiscale techniques, to derive the nonlinear Schrödinger Lax pair from the Lax pair of the system that is being modulated. It will be shown that this technique of ``multiscale averaging'' can be applied to the sine-Gordon theory to obtain not only the nonlinear Schrödinger Lax pair from the sine-Gordon Lax pair, but also the nonlinear Schrödinger spectral data, conservation laws, Θ-function solutions, and reality constraint from their sine-Gordon counterparts. This allows a physical interpretation of the mathematical elements of the nonlinear Schrödinger envelope in terms of the physical characteristics of the sine-Gordon system that is being modulated.

  17. Fatigue Damage Spectrum calculation in a Mission Synthesis procedure for Sine-on-Random excitations

    NASA Astrophysics Data System (ADS)

    Angeli, Andrea; Cornelis, Bram; Troncossi, Marco

    2016-09-01

    In many real-life environments, certain mechanical and electronic components may be subjected to Sine-on-Random vibrations, i.e. excitations composed of random vibrations superimposed on deterministic (sinusoidal) contributions, in particular sine tones due to some rotating parts of the system (e.g. helicopters, engine-mounted components,...). These components must be designed to withstand the fatigue damage induced by the “composed” vibration environment, and qualification tests are advisable for the most critical ones. In the case of an accelerated qualification test, a proper test tailoring which starts from the real environment (measured vibration signals) and which preserves not only the accumulated fatigue damage but also the “nature” of the excitation (i.e. sinusoidal components plus random process) is important to obtain reliable results. In this paper, the classic time domain approach is taken as a reference for the comparison of different methods for the Fatigue Damage Spectrum (FDS) calculation in case of Sine-on-Random vibration environments. Then, a methodology to compute a Sine-on-Random specification based on a mission FDS is proposed.

  18. Short interspersed CAN SINE elements as prognostic markers in canine mammary neoplasia.

    PubMed

    Gelaleti, Gabriela B; Granzotto, Adriana; Leonel, Camila; Jardim, Bruna V; Moschetta, Marina G; Carareto, Claudia M A; Zuccari, Debora Ap P C

    2014-01-01

    The genome of mammals is characterized by a large number of non-LTR retrotransposons, and among them, the CAN SINEs are characteristics of the canine species. Small amounts of DNA freely circulate in normal blood serum and high amounts are found in human patients with cancer, characterizing it as a candidate tumor-biomarker. The aim of this study was to estimate, through its absolute expression, the number of copies of CAN SINE sequences present in free circulating DNA of female dogs with mammary cancer, in order to correlate with the clinical and pathological characteristics and the follow-up period. The copy number of CAN SINE sequences was estimated by qPCR in 28 female dogs with mammary neoplasia. The univariate analysis showed an increased number of copies in female dogs with mammary tumor in female dogs >10 years old (p=0.02) and tumor time >18 months (p<0.05). The Kaplan-Meier test demonstrated a negative correlation between an increased number of copies and survival time (p=0.03). High amounts of CAN SINE fragments can be good markers for the detection of tumor DNA in blood and may characterize it as a marker of poor prognosis, being related to female dogs with shorter survival times. This estimate can be used as a prognostic marker in non-invasive breast cancer research and is useful in predicting tumor progression and patient monitoring. PMID:24173085

  19. The LINEs and SINEs of Entamoeba histolytica: comparative analysis and genomic distribution.

    PubMed

    Bakre, Abhijeet A; Rawal, Kamal; Ramaswamy, Ram; Bhattacharya, Alok; Bhattacharya, Sudha

    2005-07-01

    Autonomous non-long terminal repeat retrotransposons are commonly referred to as long interspersed elements (LINEs). Short non-autonomous elements that borrow the LINE machinery are called SINES. The Entamoeba histolytica genome contains three classes of LINEs and SINEs. Together the EhLINEs/SINEs account for about 6% of the genome. The recognizable functional domains in all three EhLINEs included reverse transcriptase and endonuclease. A novel feature was the presence of two types of members-some with a single long ORF (less frequent) and some with two ORFs (more frequent) in both EhLINE1 and 2. The two ORFs were generated by conserved changes leading to stop codon. Computational analysis of the immediate flanking sequences for each element showed that they inserted in AT-rich sequences, with a preponderance of Ts in the upstream site. The elements were very frequently located close to protein-coding genes and other EhLINEs/SINEs. The possible influence of these elements on expression of neighboring genes needs to be determined.

  20. A new explicit solution to the lattice sine-Gordon equation

    NASA Astrophysics Data System (ADS)

    Xu, Xiaoxue; Cao, Cewen

    2016-03-01

    Based on a new discrete Lax pair, an elementary explicit solution is found for the lattice sine-Gordon equation through Riemann surface method. It contains only exponential functions, quite different from the usual higher genus solutions, expressed with complicated theta functions. The solutions to the associated models, the lattice potential MKdV equation and a special H3 equation are also discussed.

  1. Understanding the mechanisms of length scale competition: The sine-Gordan soliton case

    SciTech Connect

    Sanchez, A.; Bishop, A.R.; Dominguez-Adame, F.

    1994-08-01

    We have examined the dynamical behavior of the kink solutions of the one-dimensional sine-Gordon equation in the presence of a spatially periodic parametric perturbation. We report on a novel occurrence of length scale competition in this system and show how it can be understood by means of linear stability analysis.

  2. Overview of multi-input frequency domain modal testing methods with an emphasis on sine testing

    NASA Technical Reports Server (NTRS)

    Rost, Robert W.; Brown, David L.

    1988-01-01

    An overview of the current state of the art multiple-input, multiple-output modal testing technology is discussed. A very brief review of the current time domain methods is given. A detailed review of frequency and spatial domain methods is presented with an emphasis on sine testing.

  3. Renormalization-group analysis of layered sine-Gordon type models

    NASA Astrophysics Data System (ADS)

    Nándori, I.; Nagy, S.; Sailer, K.; Jentschura, U. D.

    2005-10-01

    We analyze the phase structure and the renormalization group (RG) flow of the generalized sine-Gordon models with nonvanishing mass terms, using the Wegner-Houghton RG method in the local potential approximation. Particular emphasis is laid upon the layered sine-Gordon (LSG) model, which is the bosonized version of the multi-flavour Schwinger model and approaches the sum of two "normal", massless sine-Gordon (SG) models in the limit of a vanishing interlayer coupling J. Another model of interest is the massive sine-Gordon (MSG) model. The leading-order approximation to the UV (ultraviolet) RG flow predicts two phases for the LSG as well as for the MSG, just as it would be expected for the SG model, where the two phases are known to be separated by the Coleman fixed point. The presence of finite mass terms (for the LSG and the MSG) leads to corrections to the UV RG flow, which are naturally identified as the "mass corrections". The leading-order mass corrections are shown to have the following consequences: (i) for the MSG model, only one phase persists, and (ii) for the LSG model, the transition temperature is modified. Within the mass-corrected UV scaling laws, the limit of J→0 is thus nonuniform with respect to the phase structure of the model. The modified phase structure of general massive sine-Gordon models is connected with the breaking of symmetries in the internal space spanned by the field variables. For the LSG, the second-order subleading mass corrections suggest that there exists a cross-over regime before the IR scaling sets in, and the nonlinear terms show explicitly that higher-order Fourier modes appear in the periodic blocked potential.

  4. Expansion of CORE-SINEs in the genome of the Tasmanian devil

    PubMed Central

    2012-01-01

    Background The genome of the carnivorous marsupial, the Tasmanian devil (Sarcophilus harrisii, Order: Dasyuromorphia), was sequenced in the hopes of finding a cure for or gaining a better understanding of the contagious devil facial tumor disease that is threatening the species’ survival. To better understand the Tasmanian devil genome, we screened it for transposable elements and investigated the dynamics of short interspersed element (SINE) retroposons. Results The temporal history of Tasmanian devil SINEs, elucidated using a transposition in transposition analysis, indicates that WSINE1, a CORE-SINE present in around 200,000 copies, is the most recently active element. Moreover, we discovered a new subtype of WSINE1 (WSINE1b) that comprises at least 90% of all Tasmanian devil WSINE1s. The frequencies of WSINE1 subtypes differ in the genomes of two of the other Australian marsupial orders. A co-segregation analysis indicated that at least 66 subfamilies of WSINE1 evolved during the evolution of Dasyuromorphia. Using a substitution rate derived from WSINE1 insertions, the ages of the subfamilies were estimated and correlated with a newly established phylogeny of Dasyuromorphia. Phylogenetic analyses and divergence time estimates of mitochondrial genome data indicate a rapid radiation of the Tasmanian devil and the closest relative the quolls (Dasyurus) around 14 million years ago. Conclusions The radiation and abundance of CORE-SINEs in marsupial genomes indicates that they may be a major player in the evolution of marsupials. It is evident that the early phases of evolution of the carnivorous marsupial order Dasyuromorphia was characterized by a burst of SINE activity. A correlation between a speciation event and a major burst of retroposon activity is for the first time shown in a marsupial genome. PMID:22559330

  5. Short Interspersed Nuclear Element (SINE) Sequences in the Genome of the Human Pathogenic Fungus Aspergillus fumigatus Af293

    PubMed Central

    Kanhayuwa, Lakkhana; Coutts, Robert H. A.

    2016-01-01

    Novel families of short interspersed nuclear element (SINE) sequences in the human pathogenic fungus Aspergillus fumigatus, clinical isolate Af293, were identified and categorised into tRNA-related and 5S rRNA-related SINEs. Eight predicted tRNA-related SINE families originating from different tRNAs, and nominated as AfuSINE2 sequences, contained target site duplications of short direct repeat sequences (4–14 bp) flanking the elements, an extended tRNA-unrelated region and typical features of RNA polymerase III promoter sequences. The elements ranged in size from 140–493 bp and were present in low copy number in the genome and five out of eight were actively transcribed. One putative tRNAArg-derived sequence, AfuSINE2-1a possessed a unique feature of repeated trinucleotide ACT residues at its 3’-terminus. This element was similar in sequence to the I-4_AO element found in A. oryzae and an I-1_AF long nuclear interspersed element-like sequence identified in A. fumigatus Af293. Families of 5S rRNA-related SINE sequences, nominated as AfuSINE3, were also identified and their 5'-5S rRNA-related regions show 50–65% and 60–75% similarity to respectively A. fumigatus 5S rRNAs and SINE3-1_AO found in A. oryzae. A. fumigatus Af293 contains five copies of AfuSINE3 sequences ranging in size from 259–343 bp and two out of five AfuSINE3 sequences were actively transcribed. Investigations on AfuSINE distribution in the fungal genome revealed that the elements are enriched in pericentromeric and subtelomeric regions and inserted within gene-rich regions. We also demonstrated that some, but not all, AfuSINE sequences are targeted by host RNA silencing mechanisms. Finally, we demonstrated that infection of the fungus with mycoviruses had no apparent effects on SINE activity. PMID:27736869

  6. A SINE species from hippopotamus and its distribution among animal species.

    PubMed

    Nomura, O; Lin, Z H; Muladno; Wada, Y; Yasue, H

    1998-07-01

    Thirty sequences of a short interspersed repetitive element (SINE) were isolated from genomic DNA of Hippopotamus amphibius (hippopotamus). RNA polymerase III split promoter sequence was observed in all of the 30 sequences; and poly(A)-like structure at 3'-end, as well as direct repeat flanking to the repetitive sequence in many of the 30 sequences. A comparison of the consensus sequence of the 30 sequences with sequences in a DNA database (DDBJ/GENBANK/EMBL) revealed 93% homology to the consensus sequence of a whale SINE, CHR-2, and 73% homology to mouse glutamic acid tRNA. Phylogenetic analysis of tRNA-related regions of the sequences with all of the mouse tRNAs revealed that glutamic acid tRNA was genetically closest to the hippopotamus SINE. In addition, the tRNA-related region of the consensus sequence was folded into a cloverleaf structure as with mouse glutamic acid tRNA. These findings led us to conclude that the SINE of hippopotamus was genetically related to a whale SINE, CHR-2 [the hippopotamus SINE was named CHR-2(hippo)] and was a retroposon derived from glutamic acid tRNA. Hipo53 and hipo95, which were the genetically most separated CHR-2(hippo) sequences in the present study, were used as a probe for dot-blot hybridization to examine the distribution of their homologous sequences among animal species. Although the distribution spectra of hipo53 and hipo95 homologous sequences in animal species differed to some extent, large amounts of both sequences were found in Hippopotamus amphibius and Globicephala macrorhynchus (whale); and small amounts in most of the animal species in Artiodactyla examined. These findings indicated that the hippopotamus and whale had more recently branched off from the clade that includes chevrotain and pecorans than the other animal species in the clade. The 30 CHR-2(hippo) sequences were aligned, and the substitution rates among the sequences were calculated with a different substitution rate model for transition and for

  7. Confirmatory Survey for the Partial Site Release at the ABB Inc. CE Winsor Site, Windsor, CT

    SciTech Connect

    W.C. Adams

    2008-06-27

    The objectives of the confirmatory surveys were to confirm that remedial actions had been effective in meeting established release criteria and that documentation accurately and adequately describes the final radiological conditions of the PSR Impacted Areas.

  8. A watt-class 1-THz backward-wave oscillator based on sine waveguide

    SciTech Connect

    Xu Xiong; Wei Yanyu; Shen Fei; Yin Hairong; Xu Jin; Gong Yubin; Wang Wenxiang

    2012-01-15

    A novel backward wave oscillator was proposed by utilizing a concise sine waveguide slow-wave structure combined with sheet electron beam to operate at terahertz frequency band. First, the design method was described, and the dispersion curve and interaction impedance of the sine waveguide were calculated, then the device oscillation frequency and operating voltage were determined. Next, the circuit transmission losses were learned over the tunable frequency range. Finally, the particle-in-cell simulation method was applied to predict its signal generation performance. The investigation results show that, the backward wave oscillator can produce over 1.9 -W peak power output at the central operating frequency of 1-THz under 27-kV operating voltage and 5-mA beam current. And the interaction efficiency at 1-THz is more than 1.4% with a circuit length of 7.2-mm. It, therefore, will be considered as a promising watt-class terahertz radiation source.

  9. A framework for backbone experimental tracking : Piezoelectric actuators, stop-sine signal and Kalman filtering

    NASA Astrophysics Data System (ADS)

    Peyret, Nicolas; Dion, Jean-Luc; Chevallier, Gael

    2016-10-01

    This paper deals with the use of piezoelectric patches for nonlinear dynamic identification. The patches are glued on the structure to identify amplitude-dependent damping and natural frequency; their positions are defined in order to perform the excitation concentrated on the first bending mode. Their locations on the structure allow to perform "stop sines" tests, as, unlike electrodynamic shakers, piezos are embedded on structures and do not modify the studied structure after the excitation signal is switched off. Although, despite the piezo and the stop-sine, the signal is still modulated by other frequency components or polluted by random signals, a post processing with the extended Kalman Filter allows a very good determination of the modal damping and the natural frequency, especially when they depends on the free vibration amplitude.

  10. Analysis, Synthesis, and Classification of Nonlinear Systems Using Synchronized Swept-Sine Method for Audio Effects

    NASA Astrophysics Data System (ADS)

    Novak, Antonin; Simon, Laurent; Lotton, Pierrick

    2010-12-01

    A new method of identification, based on an input synchronized exponential swept-sine signal, is used to analyze and synthesize nonlinear audio systems like overdrive pedals for guitar. Two different pedals are studied; the first one exhibiting a strong influence of the input signal level on its input/output law and the second one exhibiting a weak influence of this input signal level. The Synchronized Swept Sine method leads to a Generalized Polynomial Hammerstein model equivalent to the pedals under test. The behaviors of both pedals are illustrated through model-based resynthesized signals. Moreover, it is also shown that this method leads to a criterion allowing the classification of the nonlinear systems under test, according to the influence of the input signal levels on their input/output law.

  11. Darboux Transformation for the Vector Sine-Gordon Equation and Integrable Equations on a Sphere

    NASA Astrophysics Data System (ADS)

    Mikhailov, Alexander V.; Papamikos, Georgios; Wang, Jing Ping

    2016-07-01

    We propose a method for construction of Darboux transformations, which is a new development of the dressing method for Lax operators invariant under a reduction group. We apply the method to the vector sine-Gordon equation and derive its Bäcklund transformations. We show that there is a new Lax operator canonically associated with our Darboux transformation resulting an evolutionary differential-difference system on a sphere. The latter is a generalised symmetry for the chain of Bäcklund transformations. Using the re-factorisation approach and the Bianchi permutability of the Darboux transformations, we derive new vector Yang-Baxter map and integrable discrete vector sine-Gordon equation on a sphere.

  12. A Unique Presentation of Anti-RNA Polymerase III Positive Systemic Sclerosis Sine Scleroderma.

    PubMed

    Lee, Cody M; Girnita, Diana; Sharma, Arundhati; Khanna, Surabhi; Elwing, Jean M

    2016-01-01

    Systemic sclerosis is a rare autoimmune disorder with a wide spectrum of clinical manifestations and a multitude of autoantibodies that are associated with it. In the past several years, advances in serologic testing have led to research indicating important prognostic and phenotypic associations with certain subsets of autoantibodies. In particular, anti-RNA polymerase III (anti-RNAP III) has been associated with diffuse cutaneous disease, scleroderma renal crisis, a temporal relationship with malignancy, myositis, synovitis, joint contractures, and gastric antral vascular ectasia. However, anti-RNAP III has not been associated with systemic sclerosis sine scleroderma. We describe a patient with an atypical presentation of anti-RNAP III positive systemic sclerosis sine scleroderma who presented without the typical features of anti-RNAP III disease. Instead, she presented with critical digital ischemia, pulmonary arterial hypertension, gastroesophageal reflux disease, interstitial lung disease, and no clinically detectable sclerodactyly. PMID:27559487

  13. A Unique Presentation of Anti-RNA Polymerase III Positive Systemic Sclerosis Sine Scleroderma

    PubMed Central

    2016-01-01

    Systemic sclerosis is a rare autoimmune disorder with a wide spectrum of clinical manifestations and a multitude of autoantibodies that are associated with it. In the past several years, advances in serologic testing have led to research indicating important prognostic and phenotypic associations with certain subsets of autoantibodies. In particular, anti-RNA polymerase III (anti-RNAP III) has been associated with diffuse cutaneous disease, scleroderma renal crisis, a temporal relationship with malignancy, myositis, synovitis, joint contractures, and gastric antral vascular ectasia. However, anti-RNAP III has not been associated with systemic sclerosis sine scleroderma. We describe a patient with an atypical presentation of anti-RNAP III positive systemic sclerosis sine scleroderma who presented without the typical features of anti-RNAP III disease. Instead, she presented with critical digital ischemia, pulmonary arterial hypertension, gastroesophageal reflux disease, interstitial lung disease, and no clinically detectable sclerodactyly. PMID:27559487

  14. Methods of mapping from phase to sine amplitude in direct digital synthesis.

    PubMed

    Vankka, J

    1997-01-01

    There are many methods for performing functional mapping from phase to sine amplitude (e.g., ROM look-up, coarse/fine segmentation into multiple ROM's, Taylor series, CORDIC algorithm). The spectral purity of the conventional direct digital synthesizer (DDS) is also determined by the resolution of the values stored in the sine table ROM. Therefore, it is desirable to increase the resolution of the ROM. Unfortunately, larger ROM storage means higher power consumption, lower reliability, lower speed, and greatly increased costs. Different memory compression and algorithmic techniques and their effect on distortion and trade-offs are investigated in detail. A computer program has been created to simulate the effects of the memory compression and algorithmic techniques on the output spectrum of the DDS. For each memory compression and algorithmic technique, the worst case spurious response is calculated using the computer program. PMID:18244150

  15. Generation and propagation of a sine-azimuthal wavefront modulated Gaussian beam

    PubMed Central

    Lao, Guanming; Zhang, Zhaohui; Luo, Meilan; Zhao, Daomu

    2016-01-01

    We introduce a method for modulating the Gaussian beam by means of sine-azimuthal wavefront and carry out the experimental generation. The analytical propagation formula of such a beam passing through a paraxial ABCD optical system is derived, by which the intensity properties of the sine-azimuthal wavefront modulated Gaussian (SWMG) beam are examined both theoretically and experimentally. Both of the experimental and theoretical results show that the SWMG beam goes through the process from beam splitting to a Gaussian-like profile, which is closely determined by the phase factor and the propagation distance. Appropriate phase factor and short distance are helpful for the splitting of beam. However, in the cases of large phase factor and focal plane, the intensity distributions tend to take a Gaussian form. Such unique features may be of importance in particle trapping and medical applications. PMID:27443798

  16. Diachronic analysis of the occupation of the steppe area of the department of Sidi Bel Abbes (Western Algeria)

    NASA Astrophysics Data System (ADS)

    Hellal, B.; Ayache, A.; Ayad, N.; Hellal, T.

    2016-06-01

    Modes of occupation of the soil of the steppe area of the department of Sidi Bel Abbes (Western Algeria) know lots of mutations during the period 1987/2013; compromising the future of pastoral activity. This dissection based on supervised classification TSAVI values (Transformed Soil Adjusted Vegetation Index) using images of remote sensing of average spatial resolution of type Landsat-TM 5 and 8. The determination of the state of occupation of the ground and validation of remote sensing map shows that the status of the halophytic/psammophytic steppes and the Matorrals are detected in 38.38 % and 55,71 % of cases, respectively. On the other hand, the steppes chamaephytic mark -9,81 % regression only, agricultural land -24,51 %, and -46,24 % dense vegetation are correctly mapped. The sensing medium resolution is therefore, in the light of these figures, a management tool of the steppe field relevant and effective, which, in addition, allows enriching the field for a proper plan for the fight against desertification.

  17. Digital calibration circuit employing composite sine wave signals

    NASA Astrophysics Data System (ADS)

    Blackmon, Fletcher A.; Reid, Robert J.

    1991-10-01

    A digital calibration circuit provides 1/3 octave center frequencies in the range of 50 Hz-12.5 kHz (25 tones) simultaneously, at the output, and at repeatable levels. The system converts digital data to an analog representation for use in calibrating hydrophones. The calibration circuit is comprised of a clock section, a counting section, a clearing section, a data storage/transfer section, and a signal conditioning section. The information that is provided to the output in analog form is stored in digital form in an EPROM within the data storage/transfer section.

  18. Collective coordinate approximation to the scattering of solitons in modified NLS and sine-Gordon models

    NASA Astrophysics Data System (ADS)

    Baron, H. E.; Zakrzewski, W. J.

    2016-06-01

    We investigate the validity of collective coordinate approximations to the scattering of two solitons in several classes of (1+1) dimensional field theory models. We consider models which are deformations of the sine-Gordon (SG) or the nonlinear Schrödinger (NLS) model which posses soliton solutions (which are topological (SG) or non-topological (NLS)). Our deformations preserve their topology (SG), but change their integrability properties, either completely or partially (models become `quasi-integrable').

  19. Hilbertian sine as an absolute measure of Bayesian inference in ISR, homeland security, medicine, and defense

    NASA Astrophysics Data System (ADS)

    Jannson, Tomasz; Wang, Wenjian; Hodelin, Juan; Forrester, Thomas; Romanov, Volodymyr; Kostrzewski, Andrew

    2016-05-01

    In this paper, Bayesian Binary Sensing (BBS) is discussed as an effective tool for Bayesian Inference (BI) evaluation in interdisciplinary areas such as ISR (and, C3I), Homeland Security, QC, medicine, defense, and many others. In particular, Hilbertian Sine (HS) as an absolute measure of BI, is introduced, while avoiding relativity of decision threshold identification, as in the case of traditional measures of BI, related to false positives and false negatives.

  20. Dressing method for the vector sine-Gordon equation and its soliton interactions

    NASA Astrophysics Data System (ADS)

    Mikhailov, Alexander V.; Papamikos, Georgios; Wang, Jing Ping

    2016-06-01

    In this paper, we develop the dressing method to study the exact solutions for the vector sine-Gordon equation. The explicit formulas for one kink and one breather are derived. The method can be used to construct multi-soliton solutions. Two soliton interactions are also studied. The formulas for position shift of the kink and position and phase shifts of the breather are given. These quantities only depend on the pole positions of the dressing matrices.

  1. On the solution of the generalized wave and generalized sine-Gordon equations

    NASA Technical Reports Server (NTRS)

    Ablowitz, M. J.; Beals, R.; Tenenblat, K.

    1986-01-01

    The generalized wave equation and generalized sine-Gordon equations are known to be natural multidimensional differential geometric generalizations of the classical two-dimensional versions. In this paper, a system of linear differential equations is associated with these equations, and it is shown how the direct and inverse problems can be solved for appropriately decaying data on suitable lines. An initial-boundary value problem is solved for these equations.

  2. Interconnection between static regimes in the LJJs described by the double sine-Gordon equation

    NASA Astrophysics Data System (ADS)

    Atanasova, P. Kh; Zemlyanaya, E. V.; Shukrinov, Yu M.

    2012-11-01

    The second harmonic contribution to the current-phase relation changes the properties of the static magnetic flux distributions in the long Josephson junction (LJJ) and inspires new homogenious and fluxon static states. We study stability properties and bifurcations of these static regimes within the frame of a model described by the double sine-Gordon equation. The critical curves behavior and the interconnection between different types of magnetic flux distributions are analyzed.

  3. Gene conversion as a secondary mechanism of short interspersed element (SINE) evolution

    SciTech Connect

    Kass, D.H.; Batzer, M.A.; Deininger, P.L. |

    1995-01-01

    The Alu repetitive family of short interspersed elements (SINEs) in primates can be subdivided into distinct subfamilies by specific diagnostic nucleotide changes. The older subfamilies are generally very abundant, while the younger subfamilies have fewer copies. Some of the youngest Alu elements are absent in the orthologous loci of nonhuman primates, indicative of recent retroposition events, the primary mode of SINE evolutions. PCR analysis of one young Alu subfamily (Sb2) member found in the low-density lipoprotein receptor gene apparently revealed the presence of this element in the green monkey, orangutan, gorilla, and chimpanzee genomes, as well as the human genome. However, sequence analysis of these genomes revealed a highly mutated, older, primate-specific Alu element was present at this position in the nonhuman primates. Comparison of the flanking DNA sequences upstream of this Alu insertion corresponded to evolution expected for standard primate phylogeny, but comparison of the Alu repeat sequences revealed that the human element departed from this phylogeny. The change in the human sequence apparently occurred by a gene conversion event only within the Alu element itself, converting it from one of the oldest to one of the youngest Alu subfamilies. Although gene conversions of Alu elements are clearly very rare, this finding shows that such events can occur and contribute to specific cases of SINE subfamily evolution.

  4. Scenario based approach for multiple source Tsunami Hazard assessment for Sines, Portugal

    NASA Astrophysics Data System (ADS)

    Wronna, M.; Omira, R.; Baptista, M. A.

    2015-08-01

    In this paper, we present a scenario-based approach for tsunami hazard assessment for the city and harbour of Sines - Portugal, one of the test-sites of project ASTARTE. Sines holds one of the most important deep-water ports which contains oil-bearing, petrochemical, liquid bulk, coal and container terminals. The port and its industrial infrastructures are facing the ocean southwest towards the main seismogenic sources. This work considers two different seismic zones: the Southwest Iberian Margin and the Gloria Fault. Within these two regions, we selected a total of six scenarios to assess the tsunami impact at the test site. The tsunami simulations are computed using NSWING a Non-linear Shallow Water Model With Nested Grids. In this study, the static effect of tides is analysed for three different tidal stages MLLW (mean lower low water), MSL (mean sea level) and MHHW (mean higher high water). For each scenario, inundation is described by maximum values of wave height, flow depth, drawback, runup and inundation distance. Synthetic waveforms are computed at virtual tide gauges at specific locations outside and inside the harbour. The final results describe the impact at Sines test site considering the single scenarios at mean sea level, the aggregate scenario and the influence of the tide on the aggregate scenario. The results confirm the composite of Horseshoe and Marques Pombal fault as the worst case scenario. It governs the aggregate scenario with about 60 % and inundates an area of 3.5 km2.

  5. SINE insertions in cladistic analyses and the phylogenetic affiliations of Tarsius bancanus to other primates.

    PubMed Central

    Schmitz, J; Ohme, M; Zischler, H

    2001-01-01

    Transpositions of Alu sequences, representing the most abundant primate short interspersed elements (SINE), were evaluated as molecular cladistic markers to analyze the phylogenetic affiliations among the primate infraorders. Altogether 118 human loci, containing intronic Alu elements, were PCR analyzed for the presence of Alu sequences at orthologous sites in each of two strepsirhine, New World and Old World monkey species, Tarsius bancanus, and a nonprimate outgroup. Fourteen size-polymorphic amplification patterns exhibited longer fragments for the anthropoids (New World and Old World monkeys) and T. bancanus whereas shorter fragments were detected for the strepsirhines and the outgroup. From these, subsequent sequence analyses revealed three Alu transpositions, which can be regarded as shared derived molecular characters linking tarsiers and anthropoid primates. Concerning the other loci, scenarios are represented in which different SINE transpositions occurred independently in the same intron on the lineages leading both to the common ancestor of anthropoids and to T. bancanus, albeit at different nucleotide positions. Our results demonstrate the efficiency and possible pitfalls of SINE transpositions used as molecular cladistic markers in tracing back a divergence point in primate evolution over 40 million years old. The three Alu insertions characterized underpin the monophyly of haplorhine primates (Anthropoidea and Tarsioidea) from a novel perspective. PMID:11156996

  6. L1-mediated retrotransposition of murine B1 and B2 SINEs recapitulated in cultured cells.

    PubMed

    Dewannieux, Marie; Heidmann, Thierry

    2005-06-01

    SINEs are short interspersed nucleotide elements with transpositional activity, present at a high copy number (up to a million) in mammalian genomes. They are 80-400 bp long, non-coding sequences which derive either from the 7SL RNA (e.g. human Alus, murine B1s) or tRNA (e.g. murine B2s) polymerase III-driven genes. We have previously demonstrated that Alus very efficiently divert the enzymatic machinery of the autonomous L1 LINE (long interspersed nucleotide element) retrotransposons to transpose at a high rate. Here we show, using an ex vivo assay for transposition, that both B1 and B2 SINEs can be mobilized by murine LINEs, with the hallmarks of a bona fide retrotransposition process, including target site duplications of varying lengths and integrations into A-rich sequences. Despite different phylogenetic origins, transposition of the tRNA-derived B2 sequences is as efficient as that of the human Alus, whereas that of B1s is 20-100-fold lower despite a similar high copy number of these elements in the mouse genome. We provide evidence, via an appropriate nucleotide substitution within the B1 sequence in a domain essential for its intracellular targeting, that the current B1 SINEs are not optimal for transposition, a feature most probably selected for the host sake in the course of evolution.

  7. Pulsed dc- and sine-wave-excited cold atmospheric plasma plumes: A comparative analysis

    NASA Astrophysics Data System (ADS)

    Xiong, Q.; Lu, X. P.; Ostrikov, K.; Xian, Y.; Zou, C.; Xiong, Z.; Pan, Y.

    2010-04-01

    Cold atmospheric-pressure plasma plumes are generated in the ambient air by a single-electrode plasma jet device powered by pulsed dc and ac sine-wave excitation sources. Comprehensive comparisons of the plasma characteristics, including electrical properties, optical emission spectra, gas temperatures, plasma dynamics, and bacterial inactivation ability of the two plasmas are carried out. It is shown that the dc pulse excited plasma features a much larger discharge current and stronger optical emission than the sine-wave excited plasma. The gas temperature in the former discharge remains very close to the room temperature across the entire plume length; the sine-wave driven discharge also shows a uniform temperature profile, which is 20-30 degrees higher than the room temperature. The dc pulse excited plasma also shows a better performance in the inactivation of gram-positive staphylococcus aureus bacteria. These results suggest that the pulsed dc electric field is more effective for the generation of nonequilibrium atmospheric pressure plasma plumes for advanced plasma health care applications.

  8. Phonetic matching of auditory and visual speech develops during childhood: evidence from sine-wave speech.

    PubMed

    Baart, Martijn; Bortfeld, Heather; Vroomen, Jean

    2015-01-01

    The correspondence between auditory speech and lip-read information can be detected based on a combination of temporal and phonetic cross-modal cues. Here, we determined the point in developmental time at which children start to effectively use phonetic information to match a speech sound with one of two articulating faces. We presented 4- to 11-year-olds (N=77) with three-syllabic sine-wave speech replicas of two pseudo-words that were perceived as non-speech and asked them to match the sounds with the corresponding lip-read video. At first, children had no phonetic knowledge about the sounds, and matching was thus based on the temporal cues that are fully retained in sine-wave speech. Next, we trained all children to perceive the phonetic identity of the sine-wave speech and repeated the audiovisual (AV) matching task. Only at around 6.5 years of age did the benefit of having phonetic knowledge about the stimuli become apparent, thereby indicating that AV matching based on phonetic cues presumably develops more slowly than AV matching based on temporal cues.

  9. Polyphyletic origin of cultivated rice: based on the interspersion pattern of SINEs.

    PubMed

    Cheng, Chaoyang; Motohashi, Reiko; Tsuchimoto, Suguru; Fukuta, Yoshimichi; Ohtsubo, Hisako; Ohtsubo, Eiichi

    2003-01-01

    The wild rice species Oryza rufipogon with wide intraspecific variation is thought to be the progenitor of the cultivated rice species Oryza sativa with two ecotypes, japonica and indica. To determine the origin of cultivated rice, subfamily members of the rice retroposon p-SINE1, which show insertion polymorphism in the O. sativa -O. rufipogon population, were identified and used to "bar code" each of 101 cultivated and wild rice strains based on the presence or absence of the p-SINE1 members at the respective loci. A phylogenetic tree constructed based on the bar codes given to the rice strains showed that O. sativa strains were classified into two groups corresponding to japonica and indica, whereas O. rufipogon strains were in four groups, in which annual O. rufipogon strains formed a single group, differing from the perennial O. rufipogon strains of the other three groups. Japonica strains were closely related to the O. rufipogon perennial strains of one group, and the indica strains were closely related to the O. rufipogon annual strains, indicating that O. sativa has been derived polyphyletically from O. rufipogon. The subfamily members of p-SINE1 constitute a powerful tool for studying the classification and relationship of rice strains, even when one has limited knowledge of morphology, taxonomy, physiology, and biochemistry of rice strains. PMID:12519908

  10. Plane wave holonomies in quantum gravity. II. A sine wave solution

    NASA Astrophysics Data System (ADS)

    Neville, Donald E.

    2015-08-01

    This paper constructs an approximate sinusoidal wave packet solution to the equations of canonical gravity. The theory uses holonomy-flux variables with support on a lattice (LHF =lattice-holonomy flux ). There is an SU(2) holonomy on each edge of the LHF simplex, and the goal is to study the behavior of these holonomies under the influence of a passing gravitational wave. The equations are solved in a small sine approximation: holonomies are expanded in powers of sines and terms beyond sin2 are dropped; also, fields vary slowly from vertex to vertex. The wave is unidirectional and linearly polarized. The Hilbert space is spanned by a set of coherent states tailored to the symmetry of the plane wave case. Fixing the spatial diffeomorphisms is equivalent to fixing the spatial interval between vertices of the loop quantum gravity lattice. This spacing can be chosen such that the eigenvalues of the triad operators are large, as required in the small sine limit, even though the holonomies are not large. Appendices compute the energy of the wave, estimate the lifetime of the coherent state packet, discuss circular polarization and coarse-graining, and determine the behavior of the spinors used in the U(N) SHO realization of LQG.

  11. MLP based models to predict PM10, O3 concentrations, in Sines industrial area

    NASA Astrophysics Data System (ADS)

    Durao, R.; Pereira, M. J.

    2012-04-01

    Sines is an important Portuguese industrial area located southwest cost of Portugal with important nearby protected natural areas. The main economical activities are related with this industrial area, the deep-water port, petrochemical and thermo-electric industry. Nevertheless, tourism is also an important economic activity especially in summer time with potential to grow. The aim of this study is to develop prediction models of pollutant concentration categories (e.g. low concentration and high concentration) in order to provide early warnings to the competent authorities who are responsible for the air quality management. The knowledge in advanced of pollutant high concentrations occurrence will allow the implementation of mitigation actions and the release of precautionary alerts to population. The regional air quality monitoring network consists in three monitoring stations where a set of pollutants' concentrations are registered on a continuous basis. From this set stands out the tropospheric ozone (O3) and particulate matter (PM10) due to the high concentrations occurring in the region and their adverse effects on human health. Moreover, the major industrial plants of the region monitor SO2, NO2 and particles emitted flows at the principal chimneys (point sources), also on a continuous basis,. Therefore Artificial neuronal networks (ANN) were the applied methodology to predict next day pollutant concentrations; due to the ANNs structure they have the ability to capture the non-linear relationships between predictor variables. Hence the first step of this study was to apply multivariate exploratory techniques to select the best predictor variables. The classification trees methodology (CART) was revealed to be the most appropriate in this case.. Results shown that pollutants atmospheric concentrations are mainly dependent on industrial emissions and a complex combination of meteorological factors and the time of the year. In the second step, the Multi

  12. Multiple source genes of HAmo SINE actively expanded and ongoing retroposition in cyprinid genomes relying on its partner LINE

    PubMed Central

    2010-01-01

    Background We recently characterized HAmo SINE and its partner LINE in silver carp and bighead carp based on hybridization capture of repetitive elements from digested genomic DNA in solution using a bead-probe [1]. To reveal the distribution and evolutionary history of SINEs and LINEs in cyprinid genomes, we performed a multi-species search for HAmo SINE and its partner LINE using the bead-probe capture and internal-primer-SINE polymerase chain reaction (PCR) techniques. Results Sixty-seven full-size and 125 internal-SINE sequences (as well as 34 full-size and 9 internal sequences previously reported in bighead carp and silver carp) from 17 species of the family Cyprinidae were aligned as well as 14 new isolated HAmoL2 sequences. Four subfamilies (type I, II, III and IV), which were divided based on diagnostic nucleotides in the tRNA-unrelated region, expanded preferentially within a certain lineage or within the whole family of Cyprinidae as multiple active source genes. The copy numbers of HAmo SINEs were estimated to vary from 104 to 106 in cyprinid genomes by quantitative RT-PCR. Over one hundred type IV members were identified and characterized in the primitive cyprinid Danio rerio genome but only tens of sequences were found to be similar with type I, II and III since the type IV was the oldest subfamily and its members dispersed in almost all investigated cyprinid fishes. For determining the taxonomic distribution of HAmo SINE, inter-primer SINE PCR was conducted in other non-cyprinid fishes, the results shows that HAmo SINE- related sequences may disperse in other families of order Cypriniforms but absent in other orders of bony fishes: Siluriformes, Polypteriformes, Lepidosteiformes, Acipenseriformes and Osteoglossiforms. Conclusions Depending on HAmo LINE2, multiple source genes (subfamilies) of HAmo SINE actively expanded and underwent retroposition in a certain lineage or within the whole family of Cyprinidae. From this perspective, HAmo SINE should

  13. Drop Test Results for the Combustion Engineering Model No. ABB-2901 Fuel Pellet Shipping Package

    SciTech Connect

    Mok, G; Hagler, L

    2002-06-01

    Steel cylindrical drums have been used for many years to transport radioactive materials. The radioactive material inserted into the drum cavity for shipping is usually restrained within its own container or containment vessel. For additional protection, the container is surrounded or supported by components made of impact-absorbent and/or thermal-insulation materials. The components are expected to protect the container and its radioactive contents under severe transportation conditions like free drops and fires. Due to its simplicity and convenience, bolted-ring drum closures are commonly used to close many drum packages. Because the structural integrity of the drum and drum closure often play a significant role in determining the package's ability to maintain sub-criticality, shielding, and containment of the radioactive contents, regulations require that the complete drum package be tested for safety performance. The structural integrity of the drum body is relatively simple to understand and analyze, whereas analyzing the integrity of the drum closure is not so simple. In summary, the drop test accomplished its mission. Because the lid and closure device separated from the drum body in the 30-ft 17.5{sup o} shallow-angle drop, the drop test confirmed that the common drum closure with a bolted ring is vulnerable to damage by a shallow-angle drop, even though the closure has been shown to survive much steeper-angle drops. The test program also demonstrated one of the mechanisms by which the shallow-angle drop opens the common bolted-ring drum closure. The separation of the drum lid and closure device from the drum body was initiated by a large outward buckling deformation of the lid and completed with minimal assistance by the round plywood boards behind the lid. The energy spent to complete the separation appeared to be only a small fraction of the total impact energy. Limited to only one test, the present test program could not explore all possible mechanisms

  14. Deterministic approach for multiple-source tsunami hazard assessment for Sines, Portugal

    NASA Astrophysics Data System (ADS)

    Wronna, M.; Omira, R.; Baptista, M. A.

    2015-11-01

    In this paper, we present a deterministic approach to tsunami hazard assessment for the city and harbour of Sines, Portugal, one of the test sites of project ASTARTE (Assessment, STrategy And Risk Reduction for Tsunamis in Europe). Sines has one of the most important deep-water ports, which has oil-bearing, petrochemical, liquid-bulk, coal, and container terminals. The port and its industrial infrastructures face the ocean southwest towards the main seismogenic sources. This work considers two different seismic zones: the Southwest Iberian Margin and the Gloria Fault. Within these two regions, we selected a total of six scenarios to assess the tsunami impact at the test site. The tsunami simulations are computed using NSWING, a Non-linear Shallow Water model wIth Nested Grids. In this study, the static effect of tides is analysed for three different tidal stages: MLLW (mean lower low water), MSL (mean sea level), and MHHW (mean higher high water). For each scenario, the tsunami hazard is described by maximum values of wave height, flow depth, drawback, maximum inundation area and run-up. Synthetic waveforms are computed at virtual tide gauges at specific locations outside and inside the harbour. The final results describe the impact at the Sines test site considering the single scenarios at mean sea level, the aggregate scenario, and the influence of the tide on the aggregate scenario. The results confirm the composite source of Horseshoe and Marques de Pombal faults as the worst-case scenario, with wave heights of over 10 m, which reach the coast approximately 22 min after the rupture. It dominates the aggregate scenario by about 60 % of the impact area at the test site, considering maximum wave height and maximum flow depth. The HSMPF scenario inundates a total area of 3.5 km2.

  15. Advanced Sine Wave Modulation of Continuous Wave Laser System for Atmospheric CO2 Differential Absorption Measurements

    NASA Technical Reports Server (NTRS)

    Campbell, Joel F.; Lin, Bing; Nehrir, Amin R.

    2014-01-01

    NASA Langley Research Center in collaboration with ITT Exelis have been experimenting with Continuous Wave (CW) laser absorption spectrometer (LAS) as a means of performing atmospheric CO2 column measurements from space to support the Active Sensing of CO2 Emissions over Nights, Days, and Seasons (ASCENDS) mission.Because range resolving Intensity Modulated (IM) CW lidar techniques presented here rely on matched filter correlations, autocorrelation properties without side lobes or other artifacts are highly desirable since the autocorrelation function is critical for the measurements of lidar return powers, laser path lengths, and CO2 column amounts. In this paper modulation techniques are investigated that improve autocorrelation properties. The modulation techniques investigated in this paper include sine waves modulated by maximum length (ML) sequences in various hardware configurations. A CW lidar system using sine waves modulated by ML pseudo random noise codes is described, which uses a time shifting approach to separate channels and make multiple, simultaneous online/offline differential absorption measurements. Unlike the pure ML sequence, this technique is useful in hardware that is band pass filtered as the IM sine wave carrier shifts the main power band. Both amplitude and Phase Shift Keying (PSK) modulated IM carriers are investigated that exibit perfect autocorrelation properties down to one cycle per code bit. In addition, a method is presented to bandwidth limit the ML sequence based on a Gaussian filter implemented in terms of Jacobi theta functions that does not seriously degrade the resolution or introduce side lobes as a means of reducing aliasing and IM carrier bandwidth.

  16. Regularization of multi-soliton form factors in sine-Gordon model

    NASA Astrophysics Data System (ADS)

    Pálmai, T.

    2012-08-01

    A general and systematic regularization is developed for the exact solitonic form factors of exponential operators in the (1+1)-dimensional sine-Gordon model by analytical continuation of their integral representations. The procedure is implemented in Mathematica. Test results are shown for four- and six-soliton form factors. Catalogue identifier: AEMG_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEMG_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 1462 No. of bytes in distributed program, including test data, etc.: 15 488 Distribution format: tar.gz Programming language: Mathematica [1] Computer: PC Operating system: Cross-platform Classification: 7.7, 11.1, 23 Nature of problem: The multi-soliton form factors of the sine-Gordon model (relevant in two-dimensional physics) were given only by highly non-trivial integral representation with a limited domain of convergence. Practical applications of the form factors, e.g. calculation of correlation functions in two-dimensional condensed matter systems, were not possible in general. Solution method: Using analytic continuation techniques an efficient algorithm is found and implemented in Mathematica, which provides a general and systematic way to calculate multi-soliton form factors in the sine-Gordon model. The package contains routines to compute the two-, four- and six-soliton form factors. Running time: Strongly dependent on the desired accuracy and the number of solitons. For physical rapidities after an initialization of about 30 s, the calculation of the two-, four- and six-soliton form factors at a single point takes approximately 0.5 s, 2.5 s and 8 s, respectively. Wolfram Research, Inc., Mathematica Edition: Version 7.0, Wolfram Research, Inc., Champaign, Illinois, 2008.

  17. Selective inhibitors of nuclear export (SINE)--a novel class of anti-cancer agents.

    PubMed

    Parikh, Kaushal; Cang, Shundong; Sekhri, Arunabh; Liu, Delong

    2014-10-15

    Dysregulation of the nucleo-cytoplasmic transport of proteins plays an important role in carcinogenesis. The nuclear export of proteins depends on the activity of transport proteins, exportins. Exportins belong to the karyopherin β superfamily. Exportin-1 (XPO1), also known as chromosomal region maintenance 1 (CRM1), mediates transport of around 220 proteins. In this review, we summarized the development of a new class of antitumor drugs, collectively known as selective inhibitors of nuclear export (SINE). KPT-330 (selinexor) as an oral agent is showing activities in early clinical trials in both solid tumors and hematological malignancies.

  18. Quantum Creep and Quantum-Creep Transitions in 1D Sine-Gordon Chains.

    PubMed

    Krajewski, Florian R; Müser, Martin H

    2004-01-23

    Discrete sine-Gordon (SG) chains are studied with path-integral molecular dynamics. Chains commensurate with the substrate show the transition from pinning to quantum creep at bead masses slightly larger than in the continuous SG model. Within the creep regime, a field-driven transition from creep to complete depinning is identified. The effects of disorder on the chain's dynamics depend on the potential's roughness exponent H. For example, quantum fluctuations are generally too small to depin the chain if H=1/2, while an H=0 chain can be pinned or unpinned depending on the bead masses. Thermal fluctuations always depin the chain. PMID:14753858

  19. Amplitude estimation of a sine function based on confidence intervals and Bayes' theorem

    NASA Astrophysics Data System (ADS)

    Eversmann, D.; Pretz, J.; Rosenthal, M.

    2016-05-01

    This paper discusses the amplitude estimation using data originating from a sine-like function as probability density function. If a simple least squares fit is used, a significant bias is observed if the amplitude is small compared to its error. It is shown that a proper treatment using the Feldman-Cousins algorithm of likelihood ratios allows one to construct improved confidence intervals. Using Bayes' theorem a probability density function is derived for the amplitude. It is used in an application to show that it leads to better estimates compared to a simple least squares fit.

  20. Mass of the sine-Gordon soliton in the Hartree approximation

    NASA Astrophysics Data System (ADS)

    Altenbokum, M.; Kaulfuss, U.; Verbaarschot, J. J. M.

    1986-09-01

    We derive the quantum corrections to the mass of the one-soliton solution of the sine-Gordon system in the Hartree approximation. In the weak-coupling limit we reproduce the semiclassical correction to the soliton mass. This happens only after a nontrivial cancellation of contributions related to the deformation of the soliton due to quantum fluctuations. Numerical results are obtained up to the critical value of the coupling constant as given by Coleman. In approaching the critical point we find an increasing number of discrete modes which seem to build up a new continuum with a lower mass.

  1. Frequency-dependent effects of sine-wave cranial transcutaneous electrical nerve stimulation in human subjects.

    PubMed

    Taylor, D N; Lee, C T

    1992-01-01

    In a double-blind protocol, ninety healthy volunteer subjects received 30 minutes of constant current sine-wave cranial transcutaneous electrical nerve stimulation (TENS) of 5 Hertz (Hz), 100 Hz, or 2000 Hz frequency (current maintained below .5 mA for safety), placebo TENS, or no treatment. The five groups were compared on pre- to posttreatment changes in blood pressure, heart rate, peripheral temperature, and anxiety. Analysis showed significant reductions in systolic and diastolic blood pressure and heart rate after 100 Hz cranial TENS as compared to the other groups. No other differences achieved significance. PMID:1357927

  2. Criteria for representing circular arc and sine wave spar webs by non-curved elements

    NASA Technical Reports Server (NTRS)

    Jenkins, J. M.

    1979-01-01

    The basic problem of how to simply represent a curved web of a spar in a finite element structural model was addressed. The ratio of flat web to curved web axial deformations and longitudinal rotations were calculated using NASTRAN models. Multiplying factors were developed from these calculations for various web thicknesses. These multiplying factors can be applied directly to the area and moment of inertia inputs of the finite element model. This allows the thermal stress relieving configurations of sine wave and circular arc webs to be simply accounted for in finite element structural models.

  3. Nonperturbative study of the two-frequency sine-Gordon model

    NASA Astrophysics Data System (ADS)

    Bajnok, Z.; Palla, L.; Takács, G.; Wágner, F.

    2001-05-01

    The two-frequency sine-Gordon model is examined. The focus is mainly on the case when the ratio of the frequencies is 1/2, given the recent interest in the literature. We discuss the model both in a perturbative (form factor perturbation theory) and a nonperturbative (truncated conformal space approach) framework, and give particular attention to a phase transition conjectured earlier by Delfino and Mussardo. We give substantial evidence that the transition is of second order and that it is in the Ising universality class. Furthermore, we check the UV-IR operator correspondence and conjecture the phase diagram of the theory.

  4. Nonperturbative Analysis of the Two-Frequency Sine-Gordon Model

    NASA Astrophysics Data System (ADS)

    Bajnok, Z.; Palla, L.; Takács, G.; Wágner, F.

    2001-04-01

    The two-frequency sine-Gordon model is examined. The focus is mainly on the case when the ratio of the frequencies is 1/2, given the recent interest in the literature. We discuss the model both in a perturbative (form factor perturbation theory) and a nonperturbative (truncated conformal space approach) framework, and give particular attention to a phase transition conjectured earlier by Delfino and Mussardo. We give substantial evidence that the transition is of second order and that it is in the Ising universality class. Furthermore, we check the UV-IR operator correspondence and conjecture the phase diagram of the theory.

  5. Exact Mass-Coupling Relation for the Homogeneous Sine-Gordon Model

    NASA Astrophysics Data System (ADS)

    Bajnok, Zoltán; Balog, János; Ito, Katsushi; Satoh, Yuji; Tóth, Gábor Zsolt

    2016-05-01

    We derive the exact mass-coupling relation of the simplest multiscale quantum integrable model, i.e., the homogeneous sine-Gordon model with two mass scales. The relation is obtained by comparing the perturbed conformal field theory description of the model valid at short distances to the large distance bootstrap description based on the model's integrability. In particular, we find a differential equation for the relation by constructing conserved tensor currents, which satisfy a generalization of the Θ sum rule Ward identity. The mass-coupling relation is written in terms of hypergeometric functions.

  6. Progressive systemic sclerosis sine scleroderma in a child presenting as nocturnal seizures and Raynaud's phenomenon.

    PubMed

    Navon, P; Halevi, A; Brand, A; Branski, D; Rubinow, A

    1993-01-01

    Progressive systemic sclerosis sine scleroderma, as well as neurological manifestations of progressive systemic sclerosis are rare in adult-onset cases. Neither have been reported in children with progressive systemic sclerosis, either separately or together. We describe a six-year-old girl with nocturnal seizures and Raynaud's phenomenon of three years' duration. She died of cardiopulmonary sclerosis without ever fitting the required criteria of systemic sclerosis. Nailfold capillaroscopy revealed the specific "scleroderma-pattern" and provided the only clue for a diagnosis of progressive systemic sclerosis, confirmed eventually by skin biopsy.

  7. A Simple Robust PID Controller Design Method Based on Sine Wave Identification of the Uncertain Plant

    NASA Astrophysics Data System (ADS)

    Bucz, Štefan; Marič, Ladislav; Harsányi, Ladislav; Veselý, Vojtech

    2010-05-01

    The paper deals with the development and application of a new simple empirical approach to the design of robust PID controllers for technological processes in industrial practice. The main advantage of the proposed approach is the possibility to specify the required performance before the design algorithm implementation. Identification of characteristic data of the black-box type plant with varying parameters is carried out using the sine wave excitation signal, thus allowing to design the controller without necessarily knowing the mathematical model of the plant. The proposed approach has been verified on a real-world physical process.

  8. Short interspersed nuclear elements (SINEs) are abundant in Solanaceae and have a family-specific impact on gene structure and genome organization.

    PubMed

    Seibt, Kathrin M; Wenke, Torsten; Muders, Katja; Truberg, Bernd; Schmidt, Thomas

    2016-05-01

    Short interspersed nuclear elements (SINEs) are highly abundant non-autonomous retrotransposons that are widespread in plants. They are short in size, non-coding, show high sequence diversity, and are therefore mostly not or not correctly annotated in plant genome sequences. Hence, comparative studies on genomic SINE populations are rare. To explore the structural organization and impact of SINEs, we comparatively investigated the genome sequences of the Solanaceae species potato (Solanum tuberosum), tomato (Solanum lycopersicum), wild tomato (Solanum pennellii), and two pepper cultivars (Capsicum annuum). Based on 8.5 Gbp sequence data, we annotated 82 983 SINE copies belonging to 10 families and subfamilies on a base pair level. Solanaceae SINEs are dispersed over all chromosomes with enrichments in distal regions. Depending on the genome assemblies and gene predictions, 30% of all SINE copies are associated with genes, particularly frequent in introns and untranslated regions (UTRs). The close association with genes is family specific. More than 10% of all genes annotated in the Solanaceae species investigated contain at least one SINE insertion, and we found genes harbouring up to 16 SINE copies. We demonstrate the involvement of SINEs in gene and genome evolution including the donation of splice sites, start and stop codons and exons to genes, enlargement of introns and UTRs, generation of tandem-like duplications and transduction of adjacent sequence regions.

  9. Quantum sine-Gordon dynamics on analogue curved spacetime in a weakly imperfect scalar Bose gas

    NASA Astrophysics Data System (ADS)

    Volkoff, T. J.; Fischer, Uwe R.

    2016-07-01

    Using the coherent state functional integral expression of the partition function, we show that the sine-Gordon model on an analogue curved spacetime arises as the effective quantum field theory for phase fluctuations of a weakly imperfect Bose gas on an incompressible background superfluid flow when these fluctuations are restricted to a subspace of the single-particle Hilbert space. We consider bipartitions of the single-particle Hilbert space relevant to experiments on ultracold bosonic atomic or molecular gases, including, e.g., restriction to high- or low-energy sectors of the dynamics and spatial bipartition corresponding to tunnel-coupled planar Bose gases. By assuming full unitary quantum control in the low-energy subspace of a trapped gas, we show that (1) appropriately tuning the particle number statistics of the lowest-energy mode partially decouples the low- and high-energy sectors, allowing any low-energy single-particle wave function to define a background for sine-Gordon dynamics on curved spacetime and (2) macroscopic occupation of a quantum superposition of two states of the lowest two modes produces an analogue curved spacetime depending on two background flows, with respective weights continuously dependent on the corresponding weights of the superposed quantum states.

  10. Reverberation time measurement using integrated impulse response and sweep sine excitation

    NASA Astrophysics Data System (ADS)

    Nabuco, Marco; Brando, Paulo

    2002-11-01

    As the capacity and speed of digital processing systems becomes much higher, the integrated impulsive response for reverberation time measurements by the indirect method also becomes more feasible and faster. The MLS technique to obtain the impulse response for LTI has been developed during the last several years and it is very well reported by the bibliography. Some frequency analyzers available in the market are capable to generate and process MLS to get the impulse responses very easily. Sometimes, when the room to be tested is very reverberant, sequences of higher order and a certain number of average are necessary to assure acceptable signal-to-noise ratio. The sweep sine technique or the deconvolution method to obtain impulsive responses presents many new advantages, most of them still reported in various technical documents. This paper presents the results of application of this technique to measure the reverberation time in two different reverberation rooms. Comparisons with MLS, ensemble, and reverberation time averages are presented. The sweep sine technique repeatability was verified in a reverberation chamber for a polyurethane foam sample and showed smaller standard deviations when compared with other techniques. (To be presented in Portuguese.)

  11. Targeted Capture of Phylogenetically Informative Ves SINE Insertions in Genus Myotis.

    PubMed

    Platt, Roy N; Zhang, Yuhua; Witherspoon, David J; Xing, Jinchuan; Suh, Alexander; Keith, Megan S; Jorde, Lynn B; Stevens, Richard D; Ray, David A

    2015-05-25

    Identification of retrotransposon insertions in nonmodel taxa can be technically challenging and costly. This has inhibited progress in understanding retrotransposon insertion dynamics outside of a few well-studied species. To address this problem, we have extended a retrotransposon-based capture and sequence method (ME-Scan [mobile element scanning]) to identify insertions belonging to the Ves family of short interspersed elements (SINEs) across seven species of the bat genus Myotis. We identified between 120,000 and 143,000 SINE insertions in six taxa lacking a draft genome by comparing to the M. lucifugus reference genome. On average, each Ves insertion was sequenced to 129.6 × coverage. When mapped back to the M. lucifugus reference genome, all insertions were confidently assigned within a 10-bp window. Polymorphic Ves insertions were identified in each taxon based on their mapped locations. Using cross-species comparisons and the identified insertion positions, a presence-absence matrix was created for approximately 796,000 insertions. Dollo parsimony analysis of more than 85,000 phylogenetically informative insertions recovered strongly supported, monophyletic clades that correspond with the biogeography of each taxa. This phylogeny is similar to previously published mitochondrial phylogenies, with the exception of the placement of M. vivesi. These results support the utility of our variation on ME-Scan to identify polymorphic retrotransposon insertions in taxa without a reference genome and for large-scale retrotransposon-based phylogenetics.

  12. Nonlinear quantum-mechanical system associated with Sine-Gordon equation in (1 + 2) dimensions

    SciTech Connect

    Zarmi, Yair

    2014-10-15

    Despite the fact that it is not integrable, the (1 + 2)-dimensional Sine-Gordon equation has N-soliton solutions, whose velocities are lower than the speed of light (c = 1), for all N ≥ 1. Based on these solutions, a quantum-mechanical system is constructed over a Fock space of particles. The coordinate of each particle is an angle around the unit circle. U, a nonlinear functional of the particle number-operators, which obeys the Sine-Gordon equation in (1 + 2) dimensions, is constructed. Its eigenvalues on N-particle states in the Fock space are the slower-than-light, N-soliton solutions of the equation. A projection operator (a nonlinear functional of U), which vanishes on the single-particle subspace, is a mass-density generator. Its eigenvalues on multi-particle states play the role of the mass density of structures that emulate free, spatially extended, relativistic particles. The simplicity of the quantum-mechanical system allows for the incorporation of perturbations with particle interactions, which have the capacity to “annihilate” and “create” solitons – an effect that does not have an analog in perturbed classical nonlinear evolution equations.

  13. Speech perception of sine-wave signals by children with cochlear implants

    PubMed Central

    Nittrouer, Susan; Kuess, Jamie; Lowenstein, Joanna H.

    2015-01-01

    Children need to discover linguistically meaningful structures in the acoustic speech signal. Being attentive to recurring, time-varying formant patterns helps in that process. However, that kind of acoustic structure may not be available to children with cochlear implants (CIs), thus hindering development. The major goal of this study was to examine whether children with CIs are as sensitive to time-varying formant structure as children with normal hearing (NH) by asking them to recognize sine-wave speech. The same materials were presented as speech in noise, as well, to evaluate whether any group differences might simply reflect general perceptual deficits on the part of children with CIs. Vocabulary knowledge, phonemic awareness, and “top-down” language effects were all also assessed. Finally, treatment factors were examined as possible predictors of outcomes. Results showed that children with CIs were as accurate as children with NH at recognizing sine-wave speech, but poorer at recognizing speech in noise. Phonemic awareness was related to that recognition. Top-down effects were similar across groups. Having had a period of bimodal stimulation near the time of receiving a first CI facilitated these effects. Results suggest that children with CIs have access to the important time-varying structure of vocal-tract formants. PMID:25994709

  14. Comparison of IPDA lidar receiver sensitivity for coherent detection and for direct detection using sine-wave and pulsed modulation.

    PubMed

    Sun, Xiaoli; Abshire, James B

    2012-09-10

    We use theoretical models to compare the receiver signal to noise ratio (SNR) vs. average rate of detected signal photons for an integrated path differential absorption (IPDA) lidar using coherent detection with continuous wave (CW) lasers and direct detection with sine-wave and pulse modulations. The results show the coherent IPDA lidar has high receiver gain and narrow bandwidth to overcome the effects of detector circuit noise and background light, but the actual receiver performance can be limited by the coherent mixing efficiency, speckle and other factors. For direct detection, using sine-wave modulation allows the use of a low peak power laser transmitter and synchronous detection. The pulse modulation technique requires higher laser peak powers but is more efficient than sine-wave modulation in terms of average detected signal photon rate required to achieve a given receiver SNR. We also conducted experiments for the direct detection cases and the results agreed well with theory.

  15. Development of crop-specific transposable element (SINE) markers for studying gene flow from oilseed rape to wild radish.

    PubMed

    Prieto, J L; Pouilly, N; Jenczewski, E; Deragon, J M; Chèvre, A M

    2005-08-01

    The screening of wild populations for evidence of gene flow from a crop to a wild related species requires the unambiguous detection of crop genes within the genome of the wild species, taking into account the intraspecific variability of each species. If the crop and wild relatives share a common ancestor, as is the case for the Brassica crops and their wild relatives (subtribe Brassiceae), the species-specific markers needed to make this unambiguous detection are difficult to identify. In the model oilseed rape (Brassica napus, AACC, 2n = 38)-wild radish (Raphanus raphanistrum, RrRr, 2n = 18) system, we utilized the presence or absence of a short-interspersed element (SINE) at a given locus to develop oilseed rape-specific markers, as SINE insertions are irreversible. By means of sequence-specific amplified polymorphism (SINE-SSAP) reactions, we identified and cloned 67 bands specific to the oilseed rape genome and absent from that of wild radish. Forty-seven PCR-specific markers were developed from three combinations of primers anchored either in (1) the 5'- and 3'-genomic sequences flanking the SINE, (2) the 5'-flanking and SINE internal sequences or (3) the SINE internal and flanking 3'-sequences. Seventeen markers were monomorphic whatever the oilseed rape varieties tested, whereas 30 revealed polymorphism and behaved either as dominant (17) or co-dominant (13) markers. Polymorphic markers were mapped on 19 genomic regions assigned to ten linkage groups. The markers developed will be efficient tools to trace the occurrence and frequency of introgressions of oilseed rape genomic region within wild radish populations. PMID:15942756

  16. Power conditioning system for energy sources

    DOEpatents

    Mazumder, Sudip K.; Burra, Rajni K.; Acharya, Kaustuva

    2008-05-13

    Apparatus for conditioning power generated by an energy source includes an inverter for converting a DC input voltage from the energy source to a square wave AC output voltage, and a converter for converting the AC output voltage from the inverter to a sine wave AC output voltage.

  17. Designing a Sine-Coil for Measurement of Plasma Displacements in IR-T1 Tokamak

    SciTech Connect

    Khorshid, Pejman; Razavi, M.; Molaii, M.; Ghoranneviss, M.; TalebiTaher, A.; Arvin, R.; Mohammadi, S.; NikMohammadi, A.

    2008-04-07

    A method for the measurement of the plasma position in the IR-T1 tokamak in toroidal coordinates is developed. A sine-coil, which is a Rogowski coil with a variable wiring density is designed and fabricated for this purpose. An analytic solution of the Biot-Savart law, which is used to calculate magnetic fields created by toroidal plasma current, is presented. Results of calculations are compared with the experimental data obtained in no-plasma shots with a toroidal current-carrying coil positioned inside the vessel to simulate the plasma movements. The results are shown a good linear behavior of plasma position measurements. The error is less than 2.5% and it is compared with other methods of measurements of the plasma position. This method will be used in the feedback position control system and tests of feedback controller parameters are ongoing.

  18. Middle Atmosphere Cooperation/Summer in Northern Europe (MAC/SINE) and MAC/Epsilon

    NASA Technical Reports Server (NTRS)

    Thrane, E. V.

    1989-01-01

    Two major international campaigns dedicated to the study of middle atmosphere dynamics in high latitudes were successfully completed in 1987. MAC/SINE (Middle Atmosphere Cooperation/Summer in Northern Europe) was carried out during the period 7 June to 19 July, whereas MAC/Epsilon took place in the period 12 October to 15 November. In both campaigns a large number of ground based and rocket techniques were used in a concerted effort to map the dynamical structure of the middle atmosphere over Northern Europe. Although the analysis of the observations has only just started, it is clear that a large and unique data set was obtained, which is believed will provide new insight into the dynamical processes in this interesting region of the atmosphere. A brief overview of the campaigns, their scientific aims, organization and structure is presented.

  19. Structure of the Broken Phase of the Sine-Gordon Model Using Functional Renormalization

    NASA Astrophysics Data System (ADS)

    Pangon, V.

    We study in this paper the sine-Gordon model using functional renormalization group at local potential approximation using different renormalization group (RG) schemes. In d = 2, using Wegner-Houghton RG we demonstrate that the location of the phase boundary is entirely driven by the relative position to the Coleman fixed point even for strongly coupled bare theories. We show the existence of a set of IR fixed points in the broken phase that are reached independently of the bare coupling. The bad convergence of the Fourier series in the broken phase is discussed and we demonstrate that these fixed points can be found only using a global resolution of the effective potential. We then introduce the methodology for the use of average action method where the regulator breaks periodicity and show that it provides the same conclusions for various regulators. The behavior of the model is then discussed in d≠2 and the absence of the previous fixed points is interpreted.

  20. Application of nanoimprinting technique for fabrication of trifocal diffractive lens with sine-like radial profile

    NASA Astrophysics Data System (ADS)

    Osipov, Vladimir; Doskolovich, Leonid L.; Bezus, Evgeni A.; Drew, Tom; Zhou, Kaiming; Sawalha, Kameel; Swadener, Greg; Wolffsohn, James S. W.

    2015-02-01

    The fabrication of submicron-height sine-like relief of a trifocal diffractive zone plate using a nanoimprinting technique is studied. The zone plate is intended for use in combined trifocal diffractive-refractive lenses and provides the possibility to form trifocal intraocular lenses with predetermined light intensity distribution between foci. The optical properties of the designed zone plate having the optical powers 3 D, 0, -3 D in the three main diffraction orders are theoretically and experimentally investigated. The results of the theoretical investigations are in good agreement with experimental measurements. The effects of the pupil size (lens diameter) as well as the wavelength-dependent behavior of the zone plate are also discussed.

  1. Quantum quench dynamics of the sine-Gordon model in some solvable limits

    NASA Astrophysics Data System (ADS)

    Iucci, A.; Cazalilla, M. A.

    2010-05-01

    With regard to the thermalization problem in isolated quantum systems, we investigate the dynamics following a quantum quench of the sine-Gordon model (sGM) in the Luther-Emery and the semiclassical limits. We consider the quench from the gapped to the gapless phase, as well as the reverse one. By obtaining analytic expressions for the one- and two-point correlation functions of the order parameter operator at zero-temperature, the manifestations of integrability in the absence of thermalization in the sGM are studied. It is shown that correlations in the long-time regime after the quench are well described by a generalized Gibbs ensemble. We also consider the case where the system is initially in contact with a reservoir at finite temperature. The possible relevance of our results to current and future experiments with ultracold atomic systems is also considered.

  2. Quantum quenches in the sine-Gordon model: A semiclassical approach

    NASA Astrophysics Data System (ADS)

    Kormos, M.; Zaránd, G.

    2016-06-01

    We compute the time evolution of correlation functions after quantum quenches in the sine-Gordon model within the semiclassical approximation, which is expected to yield accurate results for small and slow quenches producing slow quasiparticles with low density. We demonstrate this by reproducing results of a recent form-factor calculation of the relaxation of expectation values [B. Bertini, D. Schuricht, and F. H. L. Essler, J. Stat. Mech. (2014) P10035, 10.1088/1742-5468/2014/10/P10035]. Extending these results, we find that—in the universal limit of vanishingly small quasiparticle velocities—the expectation values of most vertex operators do not decay to zero. We give analytic expressions for the relaxation of dynamic correlation functions and show that they have diffusive behavior for large timelike separation.

  3. Study of a high power sine waveguide traveling wave tube amplifier centered at 8 GHz

    NASA Astrophysics Data System (ADS)

    Hoff, Brad W.; Simon, David S.; French, David M.; Lau, Y. Y.; Wong, Patrick

    2016-10-01

    Performance of a 20-stage X-band sine waveguide amplifier, driven by a 40 A, 100 kV, cylindrical electron beam, is studied using numerical simulation and interpreted using Pierce's classical traveling wave tube theory. For an input signal power level of 1.8 kW, particle-in-cell simulations predict gain and bandwidth values exceeding 14 dB and 13%, respectively. For an input signal power level of 7.2 kW, particle-in-cell simulations predict gain and bandwidth values exceeding 12 dB and 15%, respectively, with output power levels exceeding 110 kW at peak gain. Also given are: an assessment of the space charge factor (Pierce's QC parameter) for the complex circuit using simulation data, and an evaluation of the harmonic contents in the beam current.

  4. Obtaining changes in calibration-coil to seismometer output constants using sine waves

    USGS Publications Warehouse

    Ringler, Adam T.; Hutt, Charles R.; Gee, Lind S.; Sandoval, Leo D.; Wilson, David C.

    2013-01-01

    The midband sensitivity of a broadband seismometer is one of the most commonly used parameters from station metadata. Thus, it is critical for station operators to robustly estimate this quantity with a high degree of accuracy. We develop an in situ method for estimating changes in sensitivity using sine‐wave calibrations, assuming the calibration coil and its drive are stable over time and temperature. This approach has been used in the past for passive instruments (e.g., geophones) but has not been applied, to our knowledge, to derive sensitivities of modern force‐feedback broadband seismometers. We are able to detect changes in sensitivity to well within 1%, and our method is capable of detecting these sensitivity changes using any frequency of sine calibration within the passband of the instrument.

  5. Lattice twist operators and vertex operators in sine-Gordon theory in one dimension

    NASA Astrophysics Data System (ADS)

    Nakamura, Masaaki; Voit, Johannes

    2002-04-01

    In one dimension, the exponential position operators introduced in a theory of polarization are identified with the twist operators appearing in the Lieb-Schultz-Mattis argument, and their finite-size expectation values z(q)L measure the overlap between the q-fold degenerate ground state and an excited state. Insulators are characterized by z∞≠0, and different states are distinguished by the sign of zL. We identify zL with ground-state expectation values of vertex operators in the sine-Gordon model. This allows an accurate detection of quantum phase transitions in the universality classes of the Gaussian and the SU(2)1 Wess-Zumino-Novikov-Witten models. We apply this theory to the half-filled extended Hubbard model and obtain agreement with the level-crossing method.

  6. Quantum quenches in the sine-Gordon model: A semiclassical approach.

    PubMed

    Kormos, M; Zaránd, G

    2016-06-01

    We compute the time evolution of correlation functions after quantum quenches in the sine-Gordon model within the semiclassical approximation, which is expected to yield accurate results for small and slow quenches producing slow quasiparticles with low density. We demonstrate this by reproducing results of a recent form-factor calculation of the relaxation of expectation values [B. Bertini, D. Schuricht, and F. H. L. Essler, J. Stat. Mech. (2014) P100351742-546810.1088/1742-5468/2014/10/P10035]. Extending these results, we find that-in the universal limit of vanishingly small quasiparticle velocities-the expectation values of most vertex operators do not decay to zero. We give analytic expressions for the relaxation of dynamic correlation functions and show that they have diffusive behavior for large timelike separation. PMID:27415202

  7. A parameter estimation algorithm for spatial sine testing - Theory and evaluation

    NASA Technical Reports Server (NTRS)

    Rost, R. W.; Deblauwe, F.

    1992-01-01

    This paper presents the theory and an evaluation of a spatial sine testing parameter estimation algorithm that uses directly the measured forced mode of vibration and the measured force vector. The parameter estimation algorithm uses an ARMA model and a recursive QR algorithm is applied for data reduction. In this first evaluation, the algorithm has been applied to a frequency response matrix (which is a particular set of forced mode of vibration) using a sliding frequency window. The objective of the sliding frequency window is to execute the analysis simultaneously with the data acquisition. Since the pole values and the modal density are obtained from this analysis during the acquisition, the analysis information can be used to help determine the forcing vectors during the experimental data acquisition.

  8. Resurgence in sine-Gordon quantum mechanics: exact agreement between multi-instantons and uniform WKB

    NASA Astrophysics Data System (ADS)

    Misumi, Tatsuhiro; Nitta, Muneto; Sakai, Norisuke

    2015-09-01

    We compute multi-instanton amplitudes in the sine-Gordon quantum mechanics (periodic cosine potential) by integrating out quasi-moduli parameters corresponding to separations of instantons and anti-instantons. We propose an extension of Bogomolnyi-Zinn-Justin prescription for multi-instanton configurations and an appropriate subtraction scheme. We obtain the multi-instanton contributions to the energy eigenvalue of the lowest band at the zeroth order of the coupling constant. For the configurations with only instantons (anti-instantons), we obtain unambiguous results. For those with both instantons and anti-instantons, we obtain results with imaginary parts, which depend on the path of analytic continuation. We show that the imaginary parts of the multi-instanton amplitudes precisely cancel the imaginary parts of the Borel resummation of the perturbation series, and verify that our results completely agree with those based on the uniform-WKB calculations, thus confirming the resurgence structure: divergent perturbation series combined with the nonperturbative multi-instanton contributions conspire to give unambiguous results. We also study the neutral bion contributions in the {C}{P}^{N-1} model on {{R}}^1× {S}^1 with a small circumference, taking account of the relative phase moduli between the fractional instanton and anti-instanton. We find that the sign of the interaction potential depends on the relative phase moduli, and that both the real and imaginary parts resulting from quasi-moduli integral of the neutral bion get quantitative corrections compared to the sine-Gordon quantum mechanics.

  9. Gravitropism in Arabidopsis thaliana: violation of the sine- and resultant-law

    NASA Astrophysics Data System (ADS)

    Galland, Paul

    We investigated the gravitropic bending of hypocotyls and roots of seedlings of Arabidopsis tha-liana in response to long-term centrifugal accelerations in a range of 5 x 10-3 to 4 x g. The so-cal-led resultant law of gravitropism, a corollary of the so called sine law, claims that during centri-fugation a gravitropic organ aligns itself parallel to the resultant stimulus vector. We show here that neither of the two empirical “laws” is apt to describe the complex gravitropic behaviour of seedlings of Arabidopsis. Hypocotyls obey reasonably well the resultant law while roots display a complex behaviour that is clearly at variance with it. Horizontally centrifuged seedlings sense minute accelerations acting parallel to the longitudinal axis. If the centrifugal vector points to-ward the cotyledons, then the bending of hypocotyls and roots is greatly enhanced. If the centri-fugal vector points, however, toward the root tip, then only the bending of roots is enhanced by accelerations as low as 5 x 10-3 x g (positive tonic effect). The absolute gravitropic thresholds were determined for hypocotyls and roots in a clinostat-centrifuge and found to be near 1.5 x 10-2 x g. A behavioural mutant, ehb1-2 (Knauer et al. 2011), displays a lower gravitropic threshold for roots, not however, for hypocotyls. The complex gravitropic behaviour of seedlings of Arabi-dopsis is at odds with the classical sine- as well as the resultant law and can indicates the eminent role that is played by the acceleration vector operating longitudinally to the seedling axis.

  10. Spatially Extended Relativistic Particles Out of Traveling Front Solutions of Sine-Gordon Equation in (1+2) Dimensions

    PubMed Central

    Zarmi, Yair

    2016-01-01

    Slower-than-light multi-front solutions of the Sine-Gordon in (1+2) dimensions, constructed through the Hirota algorithm, are mapped onto spatially localized structures, which emulate free, spatially extended, massive relativistic particles. A localized structure is an image of the junctions at which the fronts intersect. It propagates together with the multi-front solution at the velocity of the latter. The profile of the localized structure obeys the linear wave equation in (1+2) dimensions, to which a term that represents interaction with a slower-than-light, Sine-Gordon-multi-front solution has been added. This result can be also formulated in terms of a (1+2)-dimensional Lagrangian system, in which the Sine-Gordon and wave equations are coupled. Expanding the Euler-Lagrange equations in powers of the coupling constant, the zero-order part of the solution reproduces the (1+2)-dimensional Sine-Gordon fronts. The first-order part is the spatially localized structure. PACS: 02.30.Ik, 03.65.Pm, 05.45.Yv, 02.30.Ik. PMID:26930077

  11. Increased expression and copy number amplification of LINE-1 and SINE B1 retrotransposable elements in murine mammary carcinoma progression.

    PubMed

    Gualtieri, Alberto; Andreola, Federica; Sciamanna, Ilaria; Sinibaldi-Vallebona, Paola; Serafino, Annalucia; Spadafora, Corrado

    2013-11-01

    In higher eukaryotic genomes, Long Interspersed Nuclear Element 1 (LINE-1) retrotransposons and endogenous retroviruses represent large families of repeated elements encoding reverse transcriptase (RT) proteins. Short Interspersed Nuclear Element B1 (SINE B1) retrotrasposons do not encode RT, but use LINE-1-derived RT for their retrotransposition. We previously showed that many cancer types have an abundant endogenous RT activity. Inhibition of that activity, by either RNA interference-dependent silencing of active LINE-1 elements or by RT inhibitory drugs, reduced proliferation and promoted differentiation in cancer cells, indicating that LINE-1-encoded RT is required for tumor progression. Using MMTV-PyVT transgenic mice as a well-defined model of breast cancer progression, we now report that both LINE-1 and SINE B1 retrotransposons are up-regulated at a very early stage of tumorigenesis; LINE-1-encoded RT product and enzymatic activity were detected in tumor tissues as early as stage 1, preceding the widespread appearance of histological alterations and specific cancer markers, and further increased in later progression stages, while neither was present in non-pathological breast tissues. Importantly, both LINE-1 and SINE B1 retrotransposon families undergo copy number amplification during tumor progression. These findings therefore indicate that RT activity is distinctive of breast cancer cells and that, furthermore, LINE-1 and SINE B1 undergo copy number amplification during cancer progression.

  12. New exact solutions for fractional Sine-Gordon equation by using the new version of generalized F-expansion method

    NASA Astrophysics Data System (ADS)

    Pandir, Yusuf; Duzgun, Hasan Huseyin

    2016-06-01

    In this study, we investigate some new analytical solutions to the fractional Sine-Gordon equation by using the new version of generalized F-expansion method. The fractional derivatives are defined in the modified Riemann-Liouville context. As a result, new analytical solutions were obtained in terms Jacobi elliptic functions.

  13. Remarks on the Non-Linear Differential Equation the Second Derivative of Theta Plus A Sine Theta Equals 0.

    ERIC Educational Resources Information Center

    Fay, Temple H.; O'Neal, Elizabeth A.

    1985-01-01

    The authors draw together a variety of facts concerning a nonlinear differential equation and compare the exact solution with approximate solutions. Then they provide an expository introduction to the elliptic sine function suitable for presentation in undergraduate courses on differential equations. (MNS)

  14. L’abbé Gui de Mortessagnes (1714-1796), collaborateur de Faujas de Saint-Fond et pionnier de la volcanologie en Vivarais-Velay (France)

    NASA Astrophysics Data System (ADS)

    Mergoil, Jean; Mergoil-Daniel, Juliette

    2011-05-01

    Six letters from an enigmatic Abbé de Mortesagne are included in the famous book of Faujas de Saint-Fond (1778), Recherches sur les volcans éteints du Vivarais et du Velay. Examination of the records have allowed his identification as Gui de Mortessagnes and explains how this Jesuit, formerly Professor of Physics at the Montpellier College, started to make original observations about the high Vivarais-Velay volcanism. Mortessagnes first encountered Faujas at Montelimar, in 1767, as is attested by their two signatures on a legal document. Mortessagnes was after introduced to Geology in the low-Vivarais by Faujas, who then sent him to the high-Vivarais and Velay to extend their research. With accurate and original observations on volcanic products and their geological settings, he discussed the basalt nature, the interactions between basalt and sediments, and even resorted to experimental testing of basalt fusibility.

  15. Efficient three-dimensional resist profile-driven source mask optimization optical proximity correction based on Abbe-principal component analysis and Sylvester equation

    NASA Astrophysics Data System (ADS)

    Lin, Pei-Chun; Yu, Chun-Chang; Chen, Charlie Chung-Ping

    2015-01-01

    As one of the critical stages of a very large scale integration fabrication process, postexposure bake (PEB) plays a crucial role in determining the final three-dimensional (3-D) profiles and lessening the standing wave effects. However, the full 3-D chemically amplified resist simulation is not widely adopted during the postlayout optimization due to the long run-time and huge memory usage. An efficient simulation method is proposed to simulate the PEB while considering standing wave effects and resolution enhancement techniques, such as source mask optimization and subresolution assist features based on the Sylvester equation and Abbe-principal component analysis method. Simulation results show that our algorithm is 20× faster than the conventional Gaussian convolution method.

  16. Proceedings of the SMBE Tri-National Young Investigators' Workshop 2005. Baleen whale phylogeny and a past extensive radiation event revealed by SINE insertion analysis.

    PubMed

    Nikaido, Masato; Hamilton, Healy; Makino, Hitomi; Sasaki, Takeshi; Takahashi, Kazuhiko; Goto, Mutsuo; Kanda, Naohisa; Pastene, Luis A; Okada, Norihiro

    2006-05-01

    Baleen whales (suborder Mysticeti) comprise 11 extant species that are classified into four families. Although several phylogenetic hypotheses about these taxa have been proposed, their phylogenetic relationships remain confused. We addressed this problem using short interspersed repetitive element (SINE) insertion data, which now are regarded as almost ideal shared, derived characters at the molecular level. We reconstructed the phylogenetic relationships of baleen whales by characterizing 36 informative SINE loci. One of the intriguing conclusions is that balaenopterids and eschrichtiids radiated very rapidly during a very short evolutionary period. During this period, speciation occurred in balaenopterids and eschrichtiids while newly inserted SINE loci remains polymorphic. Later on, these SINEs were sorted incompletely into each lineage. Thus, there are now inconsistencies among species regarding the presence or absence of a given SINE. This is in sharp contrast to the phylogeny of toothed whales, for which no SINE inconsistencies have been found. Furthermore, we found monophyletic groupings between humpback and fin whales as well as between (sei+Bryde's) whales and blue whales, both of which have not previously been recognized. The comprehensive SINE insertion data, together with the mitochondrial DNA phylogeny that was recently completed (Sasaki, T., M. Nikaido, H. Healy et al. 2005. Mitochondrial phylogenetics and evolution of mysticete whales. Syst. Biol. 56:77-90; Rychel, A. L., T. W. Reeder, and A. Berta. 2004. Phylogeny of mysticete whales based on mitochondrial and nuclear data. Mol. Phylogenet. Evol. 32:892-901), provide a nearly complete picture of the evolutionary history of baleen whales.

  17. SINE (selective inhibitor of nuclear export)--translational science in a new class of anti-cancer agents.

    PubMed

    Gerecitano, John

    2014-10-04

    Regulation of protein trafficking between the nucleus and cytoplasm represents a novel control point for antineoplastic intervention. Several proteins involved with cellular growth and survival depend on precise and timely positioning within the cell to fulfill their functions, and the nuclear membrane defines one of the most important compartmental barriers. Chromosome Region Maintenance 1, or exportin-1 (CRM1/XPO1), is involved with the export of more than 200 nuclear proteins, and has intriguingly been shown to have an increased expression in several tumor cell types. Selinexor (KPT-330) is a first-in-class selective inhibitor of nuclear export (SINE) to be developed for clinical use. Preclinical data has demonstrated antineoplastic activity of SINE compounds in many human solid and hematologic malignancies. The clinical development of Selinexor provides an excellent model for translational research.

  18. Infinite-dimensional Estabrook-Wahlquist prolongations for the sine-Gordon equation

    NASA Astrophysics Data System (ADS)

    Finley, J. D., III; McIver, John K.

    1995-10-01

    We are looking for the universal covering algebra for all symmetries of a given partial differential equation (PDE), using the sine-Gordon equation as a typical example for a nonevolution equation. For nonevolution equations, Estabrook-Wahlquist prolongation structures for nonlocal symmetries depend on the choice of a specific subideal of the contact module to define the PDE. For each inequivalent such choice we determine the most general solution of the prolongation equations, as subalgebras of the (infinite-dimensional) algebra of all vector fields over the space of nonlocal variables associated with the PDE, in the style of Vinogradov covering spaces. We show explicitly how previously known prolongation structures, known to lie within the Kac-Moody algebra, A(1)1, are special cases of these general solutions, although we are unable to identify the most general solutions with previously studied algebras. We show the existence of gauge transformations between prolongation structures, viewed as determining connections over the solution space, and use these to relate (otherwise) distinct algebras. Faithful realizations of the universal algebra allow integral representations of the prolongation structure, opening up interesting connections with algebras of Toeplitz operators over Banach spaces, an area that has only begun to be explored.

  19. Efficient Implementation of Complex Modulated Filter Banks Using Cosine and Sine Modulated Filter Banks

    NASA Astrophysics Data System (ADS)

    Viholainen, Ari; Alhava, Juuso; Renfors, Markku

    2006-12-01

    The recently introduced exponentially modulated filter bank (EMFB) is a[InlineEquation not available: see fulltext.]-channel uniform, orthogonal, critically sampled, and frequency-selective complex modulated filter bank that satisfies the perfect reconstruction (PR) property if the prototype filter of an[InlineEquation not available: see fulltext.]-channel PR cosine modulated filter bank (CMFB) is used. The purpose of this paper is to present various implementation structures for the EMFBs in a unified framework. The key idea is to use cosine and sine modulated filter banks as building blocks and, therefore, polyphase, lattice, and extended lapped transform (ELT) type of implementation solutions are studied. The ELT-based EMFBs are observed to be very competitive with the existing modified discrete Fourier transform filter banks (MDFT-FBs) when comparing the number of multiplications/additions and the structural simplicity. In addition, EMFB provides an alternative channel stacking arrangement that could be more natural in certain subband processing applications and data transmission systems.

  20. Transforming wealth: using the inverse hyperbolic sine (IHS) and splines to predict youth's math achievement.

    PubMed

    Friedline, Terri; Masa, Rainier D; Chowa, Gina A N

    2015-01-01

    The natural log and categorical transformations commonly applied to wealth for meeting the statistical assumptions of research may not always be appropriate for adjusting for skewness given wealth's unique properties. Finding and applying appropriate transformations is becoming increasingly important as researchers consider wealth as a predictor of well-being. We present an alternative transformation-the inverse hyperbolic sine (IHS)-for simultaneously dealing with skewness and accounting for wealth's unique properties. Using the relationship between household wealth and youth's math achievement as an example, we apply the IHS transformation to wealth data from US and Ghanaian households. We also explore non-linearity and accumulation thresholds by combining IHS transformed wealth with splines. IHS transformed wealth relates to youth's math achievement similarly when compared to categorical and natural log transformations, indicating that it is a viable alternative to other transformations commonly used in research. Non-linear relationships and accumulation thresholds emerge that predict youth's math achievement when splines are incorporated. In US households, accumulating debt relates to decreases in math achievement whereas accumulating assets relates to increases in math achievement. In Ghanaian households, accumulating assets between the 25th and 50th percentiles relates to increases in youth's math achievement.

  1. Sine-Gordon modulation solutions: Application to macroscopic non-lubricant friction

    NASA Astrophysics Data System (ADS)

    Gershenzon, Naum I.; Bambakidis, Gust; Skinner, Thomas E.

    2016-10-01

    The Frenkel-Kontorova (FK) model and its continuum approximation, the sine-Gordon (SG) equation, are widely used to model a variety of important nonlinear physical systems. Many practical applications require the wave-train solution, which includes many solitons. In such cases, an important and relevant extension of these models applies Whitham's averaging procedure to the SG equation. The resulting SG modulation equations describe the behavior of important measurable system parameters that are the average of the small-scale solutions given by the SG equation. A fundamental problem of modern physics that is the topic of this paper is the description of the transitional process from a static to a dynamic frictional regime. We have shown that the SG modulation equations are a suitable apparatus for describing this transition. The model provides relations between kinematic (rupture and slip velocities) and dynamic (shear and normal stresses) parameters of the transition process. A particular advantage of the model is its ability to describe frictional processes over a wide range of rupture and slip velocities covering seismic events ranging from regular earthquakes, with rupture velocities on the order of a few km/s, to slow slip events, with rupture velocities on the order of a few km/day.

  2. Sine-Gordon model and the small k+ region of light-cone perturbation theory

    NASA Astrophysics Data System (ADS)

    Griffin, Paul A.

    1992-10-01

    The nonperturbative ultraviolet divergence of the sine-Gordon model is used to study the k+=0 region of light-cone perturbation theory. The light-cone vacuum is shown to be unstable at the nonperturbative β2=8π critical point by a light-cone version of Coleman's variational method. Vacuum bubbles, which are k+=0 diagrams in light-cone field theory and are individually finite and nonvanishing for all β, conspire to generate ultraviolet divergences of the light-cone energy density. The k+=0 region of momentum also contributes to connected Green's functions; the connected two-point function will not diverge, as it should, at the critical point unless diagrams which contribute only at k+=0 are properly included. This analysis shows in a simple way how the k+=0 region cannot be ignored even for connected diagrams. This phenomenon is expected to occur in higher-dimensional gauge theories starting at two-loop order in light-cone perturbation theory.

  3. Human interaural time difference thresholds for sine tones: The high-frequency limit

    PubMed Central

    Brughera, Andrew; Dunai, Larisa; Hartmann, William M.

    2013-01-01

    The smallest detectable interaural time difference (ITD) for sine tones was measured for four human listeners to determine the dependence on tone frequency. At low frequencies, 250–700 Hz, threshold ITDs were approximately inversely proportional to tone frequency. At mid-frequencies, 700–1000 Hz, threshold ITDs were smallest. At high frequencies, above 1000 Hz, thresholds increased faster than exponentially with increasing frequency becoming unmeasurably high just above 1400 Hz. A model for ITD detection began with a biophysically based computational model for a medial superior olive (MSO) neuron that produced robust ITD responses up to 1000 Hz, and demonstrated a dramatic reduction in ITD-dependence from 1000 to 1500 Hz. Rate-ITD functions from the MSO model became inputs to binaural display models—both place based and rate-difference based. A place-based, centroid model with a rigid internal threshold reproduced almost all features of the human data. A signal-detection version of this model reproduced the high-frequency divergence but badly underestimated low-frequency thresholds. A rate-difference model incorporating fast contralateral inhibition reproduced the major features of the human threshold data except for the divergence. A combined, hybrid model could reproduce all the threshold data. PMID:23654390

  4. Supersymmetric quantum mechanics and solitons of the sine-Gordon and nonlinear Schroedinger equations

    SciTech Connect

    Koller, Andrew; Olshanii, Maxim

    2011-12-15

    We present a case demonstrating the connection between supersymmetric quantum mechanics (SUSYQM), reflectionless scattering, and soliton solutions of integrable partial differential equations. We show that the members of a class of reflectionless Hamiltonians, namely, Akulin's Hamiltonians, are connected via supersymmetric chains to a potential-free Hamiltonian, explaining their reflectionless nature. While the reflectionless property in question has been mentioned in the literature for over two decades, the enabling algebraic mechanism was previously unknown. Our results indicate that the multisoliton solutions of the sine-Gordon and nonlinear Schroedinger equations can be systematically generated via the supersymmetric chains connecting Akulin's Hamiltonians. Our findings also explain a well-known but little-understood effect in laser physics: when a two-level atom, initially in the ground state, is subjected to a laser pulse of the form V(t)=(n({h_bar}/2{pi})/{tau})/cosh(t/{tau}), with n being an integer and {tau} being the pulse duration, it remains in the ground state after the pulse has been applied, for any choice of the laser detuning.

  5. Transforming wealth: using the inverse hyperbolic sine (IHS) and splines to predict youth's math achievement.

    PubMed

    Friedline, Terri; Masa, Rainier D; Chowa, Gina A N

    2015-01-01

    The natural log and categorical transformations commonly applied to wealth for meeting the statistical assumptions of research may not always be appropriate for adjusting for skewness given wealth's unique properties. Finding and applying appropriate transformations is becoming increasingly important as researchers consider wealth as a predictor of well-being. We present an alternative transformation-the inverse hyperbolic sine (IHS)-for simultaneously dealing with skewness and accounting for wealth's unique properties. Using the relationship between household wealth and youth's math achievement as an example, we apply the IHS transformation to wealth data from US and Ghanaian households. We also explore non-linearity and accumulation thresholds by combining IHS transformed wealth with splines. IHS transformed wealth relates to youth's math achievement similarly when compared to categorical and natural log transformations, indicating that it is a viable alternative to other transformations commonly used in research. Non-linear relationships and accumulation thresholds emerge that predict youth's math achievement when splines are incorporated. In US households, accumulating debt relates to decreases in math achievement whereas accumulating assets relates to increases in math achievement. In Ghanaian households, accumulating assets between the 25th and 50th percentiles relates to increases in youth's math achievement. PMID:25432618

  6. What the [bleep]? Enhanced absolute pitch memory for a 1000Hz sine tone.

    PubMed

    Van Hedger, Stephen C; Heald, Shannon L M; Nusbaum, Howard C

    2016-09-01

    Many individuals are able to perceive when the tuning of familiar stimuli, such as popular music recordings, has been altered. This suggests a kind of ubiquitous pitch memory, though it is unclear how this ability differs across individuals with and without absolute pitch (AP) and whether it plays any role in AP. In the present study, we take advantage of a salient single frequency - the 1000Hz sine tone used to censor taboo words in broadcast media - to assess the nature of this kind of pitch memory across individuals with and without AP. We show that non-AP participants are accurate at selecting the correct version of the censor tone among incorrect versions shifted by either one or two semitones, though their accuracy was still below that of an AP population (Experiment 1). This suggests a benefit for AP listeners that could be due to the use of explicit note categories or greater amounts of musical training. However, AP possessors still outperformed all non-AP participants when incorrect versions of the censor tone were shifted within a note category, even when controlling for musical experience (Experiment 2). Experiment 3 demonstrated that AP listeners did not appear to possess a category label for the censor tone that could have helped them differentiate the censor tones used in Experiment 2. Overall, these results suggest that AP possessors may have better pitch memory, even when divorced from pitch labeling (note categories). As such, these results have implications for how AP may develop and be maintained. PMID:27289485

  7. Development of a novel sort of exponent-sine-shaped flexure hinges

    NASA Astrophysics Data System (ADS)

    Wang, Rongqi; Zhou, Xiaoqin; Zhu, Zhiwei

    2013-09-01

    Various types of flexure hinges have been developed to construct flexural mechanisms, however, all these hinges may have limited moving accuracies, blocking performance improvements of the flexural mechanisms. In this paper, a novel sort of exponent-sine-shaped flexure hinges (ESSFHs) with asymmetric structures is proposed to achieve much higher motion accuracy. To characterize elastic deformation behavior of the ESSFHs, a novel finite beam based matrix modeling (FBMM) method is employed to calculate the compliance matrix and the defined non-dimensional precision factors without executing laborious integration operations. Furthermore, finite element analysis is conducted and compared with the FBMM method, the maximum deviation of the obtained compliances and the precision factors by the two methods is less than 8%, well demonstrating the efficiency of the analytical method. Comparisons of the accuracies of the ESSFHs and certain state-of-the-art flexure hinges verify that the proposed ESSFHs can not only significantly improve the motion accuracy but also decrease the inherent parasitic motions of conventional flexure hinges. Based on the established analytical models, influences of the dimensional parameters on the compliances and the motion accuracy of the ESSFHs are well revealed. Finally, performances of the ESSFH and the efficiency of the analytical model are well investigated by means of experimental tests.

  8. Swept sine testing of rotor-bearing system for damping estimation

    NASA Astrophysics Data System (ADS)

    Chandra, N. Harish; Sekhar, A. S.

    2014-01-01

    Many types of rotating components commonly operate above the first or second critical speed and they are subjected to run-ups and shutdowns frequently. The present study focuses on developing FRF of rotor bearing systems for damping estimation from swept-sine excitation. The principle of active vibration control states that with increase in angular acceleration, the amplitude of vibration due to unbalance will reduce and the FRF envelope will shift towards the right (or higher frequency). The frequency response function (FRF) estimated by tracking filters or Co-Quad analyzers was proved to induce an error into the FRF estimate. Using Fast Fourier Transform (FFT) algorithm and stationary wavelet transform (SWT) decomposition FRF distortion can be reduced. To obtain a theoretical clarity, the shifting of FRF envelope phenomenon is incorporated into conventional FRF expressions and validation is performed with the FRF estimated using the Fourier Transform approach. The half-power bandwidth method is employed to extract damping ratios from the FRF estimates. While deriving half-power points for both types of responses (acceleration and displacement), damping ratio (ζ) is estimated with different approximations like classical definition (neglecting damping ratio of order higher than 2), third order (neglecting damping ratios with order higher than 4) and exact (no assumptions on damping ratio). The use of stationary wavelet transform to denoise the noise corrupted FRF data is explained. Finally, experiments are performed on a test rotor excited with different sweep rates to estimate the damping ratio.

  9. An FPGA-based frequency response analyzer for multisine and stepped sine measurements on stationary and time-varying impedance

    NASA Astrophysics Data System (ADS)

    Sanchez, B.; Fernandez, X.; Reig, S.; Bragos, R.

    2014-01-01

    We report the development of a field programmable gate array (FPGA) based frequency response analyzer (FRA) for impedance frequency response function (FRF) measurements using periodic excitations, i.e. sine waves and multisines. The stepped sine measurement uses two dedicated hardware-built digital embedded multiplier blocks to extract the phase and quadrature components of the output signal. The multisine FRF measurements compute the fast Fourier transform (FFT) of the input/output signals. In this paper, we describe its design, implementation and performance evaluation, performing electrical impedance spectroscopy (EIS) measurements on phantoms. The stepped sine accuracy is 1.21% at 1 kΩ (1%), the precision is 35 mΩ and the total harmonic distortion plus noise (THD+N) is -120 dB. As for the multisine impedance FRF measurements, the magnitude and phase precision are, respectively, 0.23 Ω at 48.828 kHz and 0.021 deg at 8.087 MHz when measuring a resistor 505 Ω (1%). The magnitude accuracy is 0.55% at 8.087 MHz while the phase accuracy is 0.17 deg at 6.54 MHz. In all, the stepped sine signal-to-noise ratio (SNR) is 84 dB and 65 dB at frequencies below and above 1 MHz respectively. The SNR for the multisine FRF measurements is above 65 dB (30 kHz-10 MHz). The FRA bandwidth is 610.4 mHz-12.5 MHz and the maximum FRF measurement rate exciting with multisines starting at 30 kHz is 200 spectra s-1. Based on its technical specifications and versatility, the FRA presented can be used in many applications, e.g. for getting insight quickly into the instantaneous impedance FRF of the time-varying impedance under test.

  10. Dioxin receptor and SLUG transcription factors regulate the insulator activity of B1 SINE retrotransposons via an RNA polymerase switch.

    PubMed

    Román, Angel Carlos; González-Rico, Francisco J; Moltó, Eduardo; Hernando, Henar; Neto, Ana; Vicente-Garcia, Cristina; Ballestar, Esteban; Gómez-Skarmeta, José L; Vavrova-Anderson, Jana; White, Robert J; Montoliu, Lluís; Fernández-Salguero, Pedro M

    2011-03-01

    Complex genomes utilize insulators and boundary elements to help define spatial and temporal gene expression patterns. We report that a genome-wide B1 SINE (Short Interspersed Nuclear Element) retrotransposon (B1-X35S) has potent intrinsic insulator activity in cultured cells and live animals. This insulation is mediated by binding of the transcription factors dioxin receptor (AHR) and SLUG (SNAI2) to consensus elements present in the SINE. Transcription of B1-X35S is required for insulation. While basal insulator activity is maintained by RNA polymerase (Pol) III transcription, AHR-induced insulation involves release of Pol III and engagement of Pol II transcription on the same strand. B1-X35S insulation is also associated with enrichment of heterochromatin marks H3K9me3 and H3K27me3 downstream of B1-X35S, an effect that varies with cell type. B1-X35S binds parylated CTCF and, consistent with a chromatin barrier activity, its positioning between two adjacent genes correlates with their differential expression in mouse tissues. Hence, B1 SINE retrotransposons represent genome-wide insulators activated by transcription factors that respond to developmental, oncogenic, or toxicological stimuli. PMID:21324874

  11. A new crossover sine model based on trigonometric model and its application to the crossover lattice equation of state

    NASA Astrophysics Data System (ADS)

    Lee, Yongjin; Shin, Moon Sam; Kim, Hwayong

    2008-12-01

    In this study, a new crossover sine model (CSM) n was developed from a trigonometric model [M. E. Fisher, S. Zinn, and P. J. Upton, Phys. Rev. B 59, 14533 (1999)]. The trigonometric model is a parametric formulation model that is used to represent the thermodynamic variables near a critical point. Although there are other crossover models based on this trigonometric model, such as the CSM and the analytical sine model, which is an analytic formulation of the CSM, the new sine model (NSM) employs a different approach from these two models in terms of the connections between the parametric variables of the trigonometric model and thermodynamic variables. In order to test the performance of the NSM, the crossover lattice equation of state [M. S. Shin, Y. Lee, and H. Kim, J. Chem. Thermodyn. 40, 174 (2008)] was applied using the NSM for correlations of various pure fluids and fluid mixtures. The results showed that over a wide range of states, the crossover lattice fluid (xLF)/NSM yields the saturated properties of pure fluids and the phase behavior of binary mixtures more accurately than the original lattice equation of state. Moreover, a comparison with the crossover lattice equation of state using the CSM (xLF/CSM) showed that the new model presents good correlation results that are comparable to the xLF/CSM.

  12. A new crossover sine model based on trigonometric model and its application to the crossover lattice equation of state.

    PubMed

    Lee, Yongjin; Shin, Moon Sam; Kim, Hwayong

    2008-12-21

    In this study, a new crossover sine model (CSM) n was developed from a trigonometric model [M. E. Fisher, S. Zinn, and P. J. Upton, Phys. Rev. B 59, 14533 (1999)]. The trigonometric model is a parametric formulation model that is used to represent the thermodynamic variables near a critical point. Although there are other crossover models based on this trigonometric model, such as the CSM and the analytical sine model, which is an analytic formulation of the CSM, the new sine model (NSM) employs a different approach from these two models in terms of the connections between the parametric variables of the trigonometric model and thermodynamic variables. In order to test the performance of the NSM, the crossover lattice equation of state [M. S. Shin, Y. Lee, and H. Kim, J. Chem. Thermodyn. 40, 174 (2008)] was applied using the NSM for correlations of various pure fluids and fluid mixtures. The results showed that over a wide range of states, the crossover lattice fluid (xLF)/NSM yields the saturated properties of pure fluids and the phase behavior of binary mixtures more accurately than the original lattice equation of state. Moreover, a comparison with the crossover lattice equation of state using the CSM (xLF/CSM) showed that the new model presents good correlation results that are comparable to the xLF/CSM.

  13. Infant and early childhood mortality in the Sine-Saloum region of Senegal.

    PubMed

    Goldberg, H I; M'Bodji, F G

    1988-10-01

    Infant and early childhood mortality in Senegal's Sine-Saloum region was investigated through use o f data from a 1982-83 family health survey. The survey involved interviews with 1894 married women 15-44 years of age living in extended family residential units in rural areas. Given evidence of substantial underreporting of early deaths, at least among children born before 1980, an adjustment factor was applied to the survey data. Infant mortality was estimated to be about 113/1000 live births and mortality before age 5 years was 263/1000. Strong mortality differentials, particularly after infancy, were noted according to the 2 socioeconomic variables included in the analysis: type of house and father's occupation. The probability of dying at ages 1-4 years was 50% higher among children living in traditional homes than among those in modern homes as well as among children whose fathers' were engaged in primary sector occupations (farming, livestock, fishing). Infant mortality showed no sex differential, while mortality at ages 1-4 years was 18% higher among females. Diarrheal and respiratory diseases were the 2 leading causes of death, killing at least 15% of all children by 5 years of age. Tetanus was an important cause of death during infancy, while measles and malaria were significant causes only after the 1st birthday. For all causes of death, the effect of socioeconomic status is higher in early childhood than in infancy, presumably because of the protective effect of breastfeeding. 82% of children who died had fever during their terminal illness, 51% had diarrhea, 39% had a cough, and 14% a rash. At least some mortality in this area might be prevented through treatment of these symptoms. However, calculating the degree to which particular interventions such as oral rehydration for diarrhea would reduce mortality is a complex task, requiring knowledge of replacement mortality, effectiveness of interventions, and the numbers of mothers who would utilize them

  14. Nonlinear disintegration of sine wave in the framework of the Gardner equation

    NASA Astrophysics Data System (ADS)

    Kurkin, Andrey; Talipova, Tatiana; Kurkina, Oxana; Rouvinskaya, Ekaterina; Pelinovsky, Efim

    2016-04-01

    Nonlinear disintegration of sine wave is studied in the framework of the Gardner equation (extended version of the Korteweg - de Vries equation with both quadratic and cubic nonlinear terms). Undular bores appear here as an intermediate stage of wave evolution. Our numerical computations demonstrate the features of undular bore developing for different signs of the cubic nonlinear term. If cubic nonlinear term is negative, and initial wave amplitude is large enough, two undular bores are generated from the two breaking points formed on both crest slopes (within dispersionless Gardner equation). Undular bore consists of one table-top soliton and a group of small soliton-like waves passing through the table-top soliton. If the cubic nonlinear term is positive and again the wave amplitude is large enough, the breaking points appear on crest and trough generating groups of positive and negative solitary-like pulses. It is shown that nonlinear interaction of waves happens according to one of scenarios of two-soliton interaction of "exchange" or "overtake" types with a phase shift. If small-amplitude pulses interact with large-amplitude soliton-like pulses, their speed in average is negative in the case when "free" velocity is positive. Nonlinear interaction leads to the generation of higher harmonics and spectrum width increases with amplitude increase independently of the sign of cubic nonlinear term. The breaking asymptotic k4/3 predicted within the dispersionless Gardner equation emerges during the process of undular bore development. The formation of soliton-like perturbations leads to appearance of several spectral peaks which are downshifting with time.

  15. Final Report-Confirmatory Survey Results for the ABB Combustion Engineering Site, Windsor, Connecticut; Revision 1 (DCN 5158-SR-02-1) (Docket No. 030-03754; RFTA No. 12-003)

    SciTech Connect

    ADAMS, WADE C

    2013-01-28

    The objectives of the confirmatory activities were to provide independent contractor field data reviews and to generate independent radiological data for use by the NRC in evaluating the adequacy and accuracy of the contractor's procedures and FSS results. ORAU reviewed ABB CE's decommissioning plan, final status survey plan, and the applicable soil DCGLs, which were developed based on an NRC-approved radiation dose assessment. The surveys included gamma surface scans, gamma direct measurements, and soil sampling.

  16. Toothed whale monophyly reassessed by SINE insertion analysis: the absence of lineage sorting effects suggests a small population of a common ancestral species.

    PubMed

    Nikaido, Masato; Piskurek, Oliver; Okada, Norihiro

    2007-04-01

    Morphological data have indicated that toothed whales form a monophyletic group. However, research published in the last several years has made the issue of the monophyly or paraphyly of toothed whales a subject of debate. Our group previously characterized three independent loci in which SINE insertions were shared among dolphins and sperm whales, thus supporting the traditional, morphologically based hypothesis of toothed whale monophyly. Although in recent years a few additional molecular works proposed this topology, there is still skepticism over this monophyly from the view point of molecular systematics. When the phylogeny of rapidly radiated taxa is examined using the SINE method, it is important to consider the ascertainment bias that arises when choosing a particular taxon for SINE loci screening. To overcome this methodological problem specific to the SINE method, we examined all possible topologies among sperm whales, dolphins and baleen whales by extensively screening SINE loci from species of all three lineages. We characterized nine independent SINE loci from the genomes of sperm whales and dolphins, all of which cluster sperm whales and dolphins but exclude baleen whales. Furthermore, we characterized ten independent loci from baleen whales, all of which were amplified in a common ancestor of these whales. From these observations, we conclude that toothed whales form a monophyletic group and that no ancestral SINE polymorphisms hinder their phylogenetic assignment despite the short divergence times of the major lineages of extant whales during evolution. These results suggest that a small population of common ancestors of all toothed whales ultimately diverged into the lineages of sperm whales and dolphins.

  17. A numerical scheme and some theoretical aspects for the cylindrically and spherically symmetric sine-Gordon equations

    NASA Astrophysics Data System (ADS)

    Nguyen, Lu Trong Khiem

    2016-07-01

    A finite difference formula based on the predictor-corrector technique is presented to integrate the cylindrically and spherically symmetric sine-Gordon equations numerically. Based on various numerical observations, one property of the waves of kink type is conjectured and used to explain their returning effect. Several numerical experiments are carried out and they are in excellent agreement with the existing results. In addition, the corresponding modulation solution for the two-dimensional ring-shaped kink is extended to that in three-dimension. Both numerical and theoretical aspects are utilized to verify the reliability of the proposed numerical scheme and thus the analytical modulation solutions.

  18. Verification of low frequency ac-dc transfer differences of thermal converters using sampling with sine-wave fit

    NASA Astrophysics Data System (ADS)

    Funck, Torsten; Spiegel, Thomas

    2015-09-01

    Thermal converters show significant ac-dc transfer differences at low frequencies due to nonlinearities of the heat transport mechanism and of the thermal-to-electric conversion. It is assumed that the ac-dc transfer differences at low frequencies are proportional to the input power. We have proved this assumption by an independent method with sampling techniques. A novel approach based on sine-wave fitting is used to calculate the RMS value of the sampled signal from the samples. It makes use of the low noise in a metrological environment. Expanded uncertainties in the order of 1.2 μV/V have been achieved.

  19. The effect of sine-Wiener noises on transition in a genotype selection model with time delays

    NASA Astrophysics Data System (ADS)

    Juan Ning, Li; Liu, Pei

    2016-09-01

    A genotype selection system interplay with sine-Wiener noises and time delays is investigated. Stationary probability distribution function is obtained by numerical simulations. Results show that the multiplicative bounded noise can facilitate the gene separation, while the additive bounded noise suppresses the gene separation. Besides, local time delays α and β, being in gene transformation and gene heredity progress respectively, play opposite roles in the gene selection process. What is more interesting is that there is no transition during the process of gene select when time delays α = β (i.e., the system is subjected to global time delay).

  20. Highly transparent and flexible bio-based polyimide/TiO2 and ZrO2 hybrid films with tunable refractive index, Abbe number, and memory properties

    NASA Astrophysics Data System (ADS)

    Huang, Tzu-Tien; Tsai, Chia-Liang; Tateyama, Seiji; Kaneko, Tatsuo; Liou, Guey-Sheng

    2016-06-01

    The novel bio-based polyimide (4ATA-PI) and the corresponding PI hybrids of TiO2 or ZrO2 with excellent optical properties and thermal stability have been prepared successfully. The highly transparent 4ATA-PI containing carboxylic acid groups in the backbone could provide reaction sites for organic-inorganic bonding to obtain homogeneous hybrid films. These PI hybrid films showed a tunable refractive index (1.60-1.81 for 4ATA-PI/TiO2 and 1.60-1.80 for 4ATA-PI/ZrO2), and the 4ATA-PI/ZrO2 hybrid films revealed a higher optical transparency and Abbe's number than those of the 4ATA-PI/TiO2 system due to a larger band gap of ZrO2. By introducing TiO2 and ZrO2 as the electron acceptor into the 4ATA-PI system, the hybrid materials have a lower LUMO energy level which could facilitate and stabilize the charge transfer complex. Therefore, memory devices derived from these PI hybrid films exhibited tunable memory properties from DRAM, SRAM, to WORM with a different TiO2 or ZrO2 content from 0 wt% to 50 wt% with a high ON/OFF ratio (108). In addition, the different energy levels of TiO2 and ZrO2 revealed specifically unique memory characteristics, implying the potential application of the prepared 4ATA-PI/TiO2 and 4ATA-PI/ZrO2 hybrid films in highly transparent memory devices.The novel bio-based polyimide (4ATA-PI) and the corresponding PI hybrids of TiO2 or ZrO2 with excellent optical properties and thermal stability have been prepared successfully. The highly transparent 4ATA-PI containing carboxylic acid groups in the backbone could provide reaction sites for organic-inorganic bonding to obtain homogeneous hybrid films. These PI hybrid films showed a tunable refractive index (1.60-1.81 for 4ATA-PI/TiO2 and 1.60-1.80 for 4ATA-PI/ZrO2), and the 4ATA-PI/ZrO2 hybrid films revealed a higher optical transparency and Abbe's number than those of the 4ATA-PI/TiO2 system due to a larger band gap of ZrO2. By introducing TiO2 and ZrO2 as the electron acceptor into the 4ATA-PI system

  1. [Successful treatment with acyclovir and a corticosteroid for lower cranial polyneuropathy in zoster sine herpete: a case report].

    PubMed

    Taniguchi, Daisuke; Nakahara Ph D, Toshiki; Nakajima, Sho; Nakazato, Tomoko; Mikasa, Michitaka; Furukawa Ph D, Yoshiaki

    2015-01-01

    A 62-year-old woman developed meningitis as well as acute paralysis of glossopharyngeal, vagus, and accessory nerves on the right side and also had dysfunction of the left hypoglossal nerve. Although there was no evidence of a typical cutaneous or mucosal herpetic lesion, PCR detection of varicella zoster virus (VZV)-DNA in cerebrospinal fluid confirmed the clinical diagnosis of polyneuritis cranialis due to VZV infection and zoster sine herpete. After starting intravenous acyclovir and methylprednisolone, her hypoglossal nerve palsy disappeared within a day and all other symptoms and signs dramatically improved. A rapid improvement observed in our patient suggests that the right cranial polyneuropathy could be caused by inflammation associated with epineurial edema (where the ninth, tenth, and eleventh cranial nerves pass through the right jugular foramen), whereas the exact mechanism of the twelfth cranial nerve involvement on the contralateral side is unknown. Our clinical findings indicate that acute lower cranial polyneuropathy in patients with zoster sine herpete should be treated immediately with combined administration of acyclovir and an anti-inflammatory corticosteroid. PMID:26511031

  2. Phobos low density: are macroporosity and/or water ice 'condiciones sine quibus non'?

    NASA Astrophysics Data System (ADS)

    Pajola, Maurizio; Lazzarin, Monica; Dalle Ore, Cristina; Cruikshank, Dale; Roush, Ted; Pendleton, Yvonne; Bertini, Ivano; Magrin, Sara; La Forgia, Fiorangela; Barbieri, Cesare

    2014-05-01

    heterogeneous mass distribution. Our work originates from this simple question: are macroporosity and/or water ice really necessary to justify Phobos low density? Are these 'condiciones sine quibus non'? Is it not possible to identify a mineralogical rock content which agrees both with the surface spectra and the low bulk density of Phobos without introducing bulk macroporosity and/or water ice content? The mineralogical model used to explain the surface reflectance of Phobos presented in Pajola et al., 2013, brings new insights about the interior composition of Phobos reconciling both Phobos surface spectra and its low bulk density.

  3. Iterative methods for symmetric ill-conditioned Toeplitz matrices

    SciTech Connect

    Huckle, T.

    1996-12-31

    We consider ill-conditioned symmetric positive definite, Toeplitz systems T{sub n}x = b. If we want to solve such a system iteratively with the conjugate gradient method, we can use band-Toeplitz-preconditioners or Sine-Transform-peconditioners M = S{sub n}{Lambda}S{sub n}, S{sub n} the Sine-Transform-matrix and {Lambda} a diagonal matrix. A Toeplitz matrix T{sub n} = (t{sub i-j)}{sub i}{sup n},{sub j=1} is often related to an underlying function f defined by the coefficients t{sub j}, j = -{infinity},..,-1,0, 1,.., {infinity}. There are four cases, for which we want to determine a preconditioner M: - T{sub n} is related to an underlying function which is given explicitly; - T{sub n} is related to an underlying function that is given by its Fourier coefficients; - T{sub n} is related to an underlying function that is unknown; - T{sub n} is not related to an underlying function. Especially for the first three cases we show how positive definite and effective preconditioners based on the Sine-Transform can be defined for general nonnegative underlying function f. To define M, we evaluate or estimate the values of f at certain positions, and build a Sine-transform matrix with these values as eigenvalues. Then, the spectrum of the preconditioned system is bounded from above and away from zero.

  4. Propagation properties of partially coherent electromagnetic hyperbolic-sine-Gaussian vortex beams through non-Kolmogorov turbulence.

    PubMed

    Huang, Yongping; Wang, Fanhou; Gao, Zenghui; Zhang, Bin

    2015-01-26

    Propagation properties of partially coherent electromagnetic hyperbolic-sine-Gaussian (PCESHG) vortex beams through non-Kolmogorov atmospheric turbulence, including the spectral degree of polarization and evolution behavior of coherent vortices and average intensity are investigated in detail by using the extended Huygens-Fresnel principle and the spatial power spectrum of the refractive index of non-Kolmogorov turbulence. It is shown that the motion, creation and annihilation of the coherent vortices of PCESHG vortex beams in non-Kolmogorov turbulence may appear with the increasing propagation distance, and the distance for the conservation of the topological charge depends on the turbulence parameters and beam parameters. In additions, the evolution behavior of coherent vortices, average intensity and spectral degree of polarization vary significantly for different values of the generalized exponent parameter and the generalized refractive-index structure parameter of non-Kolmogorov turbulence, and the beam parameters as well as the propagation distance. PMID:25835869

  5. Propagation properties of partially coherent electromagnetic hyperbolic-sine-Gaussian vortex beams through non-Kolmogorov turbulence.

    PubMed

    Huang, Yongping; Wang, Fanhou; Gao, Zenghui; Zhang, Bin

    2015-01-26

    Propagation properties of partially coherent electromagnetic hyperbolic-sine-Gaussian (PCESHG) vortex beams through non-Kolmogorov atmospheric turbulence, including the spectral degree of polarization and evolution behavior of coherent vortices and average intensity are investigated in detail by using the extended Huygens-Fresnel principle and the spatial power spectrum of the refractive index of non-Kolmogorov turbulence. It is shown that the motion, creation and annihilation of the coherent vortices of PCESHG vortex beams in non-Kolmogorov turbulence may appear with the increasing propagation distance, and the distance for the conservation of the topological charge depends on the turbulence parameters and beam parameters. In additions, the evolution behavior of coherent vortices, average intensity and spectral degree of polarization vary significantly for different values of the generalized exponent parameter and the generalized refractive-index structure parameter of non-Kolmogorov turbulence, and the beam parameters as well as the propagation distance.

  6. Electrical stimulation using sine waveform prevents unloading-induced muscle atrophy in the deep calf muscles of rat.

    PubMed

    Tanaka, Minoru; Hirayama, Yusuke; Fujita, Naoto; Fujino, Hidemi

    2014-09-01

    The aim of this study was to compare the effects of electrical stimulation by using rectangular and sine waveforms in the prevention of deep muscle atrophy in rat calf muscles. Rats were randomly divided into the following groups: control, hindlimb unloading (HU), and HU plus electrical stimulation (ES). The animals in the ES group were electrically stimulated using rectangular waveform (RS) on the left calves and sine waveform (SS) on the right calves, twice a day, for 2 weeks during unloading. HU for 2 weeks resulted in a loss of the muscle mass, a decrease in the cross-sectional area of the muscle fibers, and overexpression of ubiquitinated proteins in the gastrocnemius and soleus muscles. In contrast, electrical stimulation with RS attenuated the HU-induced reduction in the cross-sectional area of muscle fibers and the increase of ubiquitinated proteins in the gastrocnemius muscle. However, electrical stimulation with RS failed to prevent muscle atrophy in the deep portion of the gastrocnemius and the soleus muscles. Nevertheless, electrical stimulation with SS attenuated the HU-induced muscle atrophy and the up-regulation of ubiquitinated proteins in both gastrocnemius and soleus muscles. This indicates that SS was more effective in the prevention of deep muscle atrophy than RS. Since the skin muscle layers act like the plates of a capacitor, separated by the subcutaneous adipose layer, the SS can pass through this capacitor more easily than the RS. Hence, SS can prevent the progressive loss of muscle fibers in the deep portion of the calf muscles.

  7. Needle-array to Plate DBD Plasma Using Sine AC and Nanosecond Pulse Excitations for Purpose of Improving Indoor Air Quality.

    PubMed

    Zhang, Li; Yang, Dezheng; Wang, Wenchun; Wang, Sen; Yuan, Hao; Zhao, Zilu; Sang, Chaofeng; Jia, Li

    2016-01-01

    In this study, needle-array to plate electrode configuration was employed to generate an atmospheric air diffuse discharge using both nanosecond pulse and sine AC voltage as excitation voltage for the purpose of improving indoor air quality. Different types of voltage sources and electrode configurations are employed to optimize electrical field distribution and improve discharge stability. Discharge images, electrical characteristics, optical emission spectra, and plasma gas temperatures in both sine AC discharge and nanosecond pulse discharge were compared and the discharge stability during long operating time were discussed. Compared with the discharge excited by sine AC voltage, the nanosecond pulsed discharge is more homogenous and stable, besides, the plasma gas temperature of nanosecond pulse discharge is much lower. Using packed-bed structure, where γ- Al2O3 pellets are filled in the electrode gap, has obvious efficacy in the production of homogenous discharge. Furthermore, both sine AC discharge and nanosecond pulse discharge were used for removing formaldehyde from flowing air. It shows that nanosecond pulse discharge has a significant advantage in energy cost. And the main physiochemical processes for the generation of active species and the degradation of formaldehyde were discussed. PMID:27125663

  8. Needle-array to Plate DBD Plasma Using Sine AC and Nanosecond Pulse Excitations for Purpose of Improving Indoor Air Quality

    NASA Astrophysics Data System (ADS)

    Zhang, Li; Yang, Dezheng; Wang, Wenchun; Wang, Sen; Yuan, Hao; Zhao, Zilu; Sang, Chaofeng; Jia, Li

    2016-04-01

    In this study, needle-array to plate electrode configuration was employed to generate an atmospheric air diffuse discharge using both nanosecond pulse and sine AC voltage as excitation voltage for the purpose of improving indoor air quality. Different types of voltage sources and electrode configurations are employed to optimize electrical field distribution and improve discharge stability. Discharge images, electrical characteristics, optical emission spectra, and plasma gas temperatures in both sine AC discharge and nanosecond pulse discharge were compared and the discharge stability during long operating time were discussed. Compared with the discharge excited by sine AC voltage, the nanosecond pulsed discharge is more homogenous and stable, besides, the plasma gas temperature of nanosecond pulse discharge is much lower. Using packed-bed structure, where γ- Al2O3 pellets are filled in the electrode gap, has obvious efficacy in the production of homogenous discharge. Furthermore, both sine AC discharge and nanosecond pulse discharge were used for removing formaldehyde from flowing air. It shows that nanosecond pulse discharge has a significant advantage in energy cost. And the main physiochemical processes for the generation of active species and the degradation of formaldehyde were discussed.

  9. Needle-array to Plate DBD Plasma Using Sine AC and Nanosecond Pulse Excitations for Purpose of Improving Indoor Air Quality

    PubMed Central

    Zhang, Li; Yang, Dezheng; Wang, Wenchun; Wang, Sen; Yuan, Hao; Zhao, Zilu; Sang, Chaofeng; Jia, Li

    2016-01-01

    In this study, needle-array to plate electrode configuration was employed to generate an atmospheric air diffuse discharge using both nanosecond pulse and sine AC voltage as excitation voltage for the purpose of improving indoor air quality. Different types of voltage sources and electrode configurations are employed to optimize electrical field distribution and improve discharge stability. Discharge images, electrical characteristics, optical emission spectra, and plasma gas temperatures in both sine AC discharge and nanosecond pulse discharge were compared and the discharge stability during long operating time were discussed. Compared with the discharge excited by sine AC voltage, the nanosecond pulsed discharge is more homogenous and stable, besides, the plasma gas temperature of nanosecond pulse discharge is much lower. Using packed-bed structure, where γ- Al2O3 pellets are filled in the electrode gap, has obvious efficacy in the production of homogenous discharge. Furthermore, both sine AC discharge and nanosecond pulse discharge were used for removing formaldehyde from flowing air. It shows that nanosecond pulse discharge has a significant advantage in energy cost. And the main physiochemical processes for the generation of active species and the degradation of formaldehyde were discussed. PMID:27125663

  10. A Mammalian Conserved Element Derived from SINE Displays Enhancer Properties Recapitulating Satb2 Expression in Early-Born Callosal Projection Neurons

    PubMed Central

    Nakanishi, Akiko; Sasaki, Takeshi; Yan, Kuo; Tarabykin, Victor; Vigier, Lisa; Sumiyama, Kenta; Hirakawa, Mika; Nishihara, Hidenori; Pierani, Alessandra; Okada, Norihiro

    2011-01-01

    Short interspersed repetitive elements (SINEs) are highly repeated sequences that account for a significant proportion of many eukaryotic genomes and are usually considered “junk DNA”. However, we previously discovered that many AmnSINE1 loci are evolutionarily conserved across mammalian genomes, suggesting that they may have acquired significant functions involved in controlling mammalian-specific traits. Notably, we identified the AS021 SINE locus, located 390 kbp upstream of Satb2. Using transgenic mice, we showed that this SINE displays specific enhancer activity in the developing cerebral cortex. The transcription factor Satb2 is expressed by cortical neurons extending axons through the corpus callosum and is a determinant of callosal versus subcortical projection. Mouse mutants reveal a crucial function for Sabt2 in corpus callosum formation. In this study, we compared the enhancer activity of the AS021 locus with Satb2 expression during telencephalic development in the mouse. First, we showed that the AS021 enhancer is specifically activated in early-born Satb2+ neurons. Second, we demonstrated that the activity of the AS021 enhancer recapitulates the expression of Satb2 at later embryonic and postnatal stages in deep-layer but not superficial-layer neurons, suggesting the possibility that the expression of Satb2 in these two subpopulations of cortical neurons is under genetically distinct transcriptional control. Third, we showed that the AS021 enhancer is activated in neurons projecting through the corpus callosum, as described for Satb2+ neurons. Notably, AS021 drives specific expression in axons crossing through the ventral (TAG1−/NPY+) portion of the corpus callosum, confirming that it is active in a subpopulation of callosal neurons. These data suggest that exaptation of the AS021 SINE locus might be involved in enhancement of Satb2 expression, leading to the establishment of interhemispheric communication via the corpus callosum, a eutherian

  11. A Short Interspersed Nuclear Element (SINE)-Based Real-Time PCR Approach to Detect and Quantify Porcine Component in Meat Products.

    PubMed

    Zhang, Chi; Fang, Xin; Qiu, Haopu; Li, Ning

    2015-01-01

    Real-time PCR amplification of mitochondria gene could not be used for DNA quantification, and that of single copy DNA did not allow an ideal sensitivity. Moreover, cross-reactions among similar species were commonly observed in the published methods amplifying repetitive sequence, which hindered their further application. The purpose of this study was to establish a short interspersed nuclear element (SINE)-based real-time PCR approach having high specificity for species detection that could be used in DNA quantification. After massive screening of candidate Sus scrofa SINEs, one optimal combination of primers and probe was selected, which had no cross-reaction with other common meat species. LOD of the method was 44 fg DNA/reaction. Further, quantification tests showed this approach was practical in DNA estimation without tissue variance. Thus, this study provided a new tool for qualitative detection of porcine component, which could be promising in the QC of meat products.

  12. Linear stability of spherically symmetric and wormhole solutions supported by the sine-Gordon ghost scalar field

    SciTech Connect

    Dzhunushaliev, Vladimir; Folomeev, Vladimir; Singleton, Douglas; Myrzakulov, Ratbay

    2010-08-15

    In this paper we investigate wormhole and spherically symmetric solutions in four-dimensional gravity plus a matter source consisting of a ghost scalar field with a sine-Gordon potential. For the wormhole solutions we also include the possibility of electric and/or magnetic charges. For both types of solutions we perform a linear stability analysis and show that the wormhole solutions are stable and that when one turns on the electric and/or magnetic field the solution remains stable. The linear stability analysis of the spherically symmetric solutions indicates that they can be stable or unstable depending on one of the parameters of the system. This result for the spherically symmetric solution is nontrivial since a previous investigation of four-dimensional gravity plus a ghost scalar field with a {lambda}{phi}{sup 4} interaction found only unstable spherically symmetric solutions. Both the wormhole and spherically symmetric solutions presented here asymptotically go to anti-de Sitter space-time.

  13. Perimetry of contrast detection thresholds of moving spatial sine wave patterns. IV. The influence of the mean retinal illuminance.

    PubMed

    Koenderink, J J; Bouman, M A; Bueno de Mesquita, A E; Slappendel, S

    1978-06-01

    Contrast detection thresholds for moving sine wave gratings were obtained at the fovea and at eccentricities of 6 degrees, 21 degrees, and 50 degrees on the nasal horizontal meridian. The targets subtended from 30 X 30 minutes of arc up to 16 degrees X 16 degrees. Mean retinal illuminance was varied between 10 and 0.01 trolands. The transition from the de Vries-Rose to the Weber region occurs in the far peripheral visual field at a 2-3 decades lower illuminance level than at the fovea. The spatio-temporal contrast detection thresholds become comparable over the whole visual field if the mean distance between retinal ganglion cells is taken as a yardstick, and field width, spatial frequency, and quantum density are scaled accordingly. This means that at scotopic illuminance levels coarse or medium gratings are preferentially detected at other than foveal locations. (The fine gratings cannot be resolved at all at such levels.) It is argued that both electrophysiological and psychophysical evidence indicates that Weber behavior starts whenever some small fixed number of quantum absorptions occur within an area of 1 mean interganglion cell distance across. Or, equivalently, if a fixed small number of "neural quanta" enters a 100 X 100 micron2 area of the visual cortex.

  14. Effects of Lévy noise on the dynamics of sine-Gordon solitons in long Josephson junctions

    NASA Astrophysics Data System (ADS)

    Guarcello, Claudio; Valenti, Davide; Carollo, Angelo; Spagnolo, Bernardo

    2016-05-01

    We numerically investigate the generation of solitons in current-biased long Josephson junctions in relation to the superconducting lifetime and the voltage drop across the device. The dynamics of the junction is modelled with a sine-Gordon equation driven by an oscillating field and subject to an external non-Gaussian noise. A wide range of $\\alpha$-stable L\\'evy distributions is considered as noise source, with varying stability index $\\alpha$ and asymmetry parameter $\\beta$. In junctions longer than a critical length, the mean switching time (MST) from superconductive to the resistive state assumes a values independent of the device length. Here, we demonstrate that such a value is directly related to the mean density of solitons which move into or from the washboard potential minimum corresponding to the initial superconductive state. Moreover, we observe: (i) a connection between the total mean soliton density and the mean potential difference across the junction; (ii) an inverse behavior of the mean voltage in comparison with the MST, with varying the junction length; (iii) evidences of non-monotonic behaviors, such as stochastic resonant activation and noise enhanced stability, of MST versus the driving frequency and noise intensity for different values of $\\alpha$ and $\\beta$; (iv) finally, these non-monotonic behaviors are found to be related to the mean density of solitons formed along the junction.

  15. A population genetic study of the evolution of SINEs. II. Sequence evolution under the master copy model

    SciTech Connect

    Tachida, Hidenori

    1996-06-01

    A transient population genetic model of SINE (short interspersed repetitive element) evolution is presented, assuming the master copy model is theoretically investigated. Means and variances of consensus frequency of nucleotides, nucleotide homozygosity, and the number of shared differences that are considered to have been caused by mutations occurring in the master copy lineages are computed. All quantities investigated are shown to be monotone functions of the duration of the expansion period. Thus, they can be used to estimate the expansion period although their sampling variances are generally large. Using the theoretical results, the Sb subfamily of human Alu sequences is analyzed. First, the expansion period is estimated from the observed mean and variance of homozygosity. The expansion period is shown to be short compared to the time since the end of the expansion of the subfamily. However, the observed number of the shared differences is more than twice that expected under the master copy model with the estimated expansion period. Alternative models to explain this observation are discussed, including one with multiple master copy loci. 38 refs., 5 figs., 4 tabs.

  16. Short interspersed element (SINE) depletion and long interspersed element (LINE) abundance are not features universally required for imprinting.

    PubMed

    Cowley, Michael; de Burca, Anna; McCole, Ruth B; Chahal, Mandeep; Saadat, Ghazal; Oakey, Rebecca J; Schulz, Reiner

    2011-04-20

    Genomic imprinting is a form of gene dosage regulation in which a gene is expressed from only one of the alleles, in a manner dependent on the parent of origin. The mechanisms governing imprinted gene expression have been investigated in detail and have greatly contributed to our understanding of genome regulation in general. Both DNA sequence features, such as CpG islands, and epigenetic features, such as DNA methylation and non-coding RNAs, play important roles in achieving imprinted expression. However, the relative importance of these factors varies depending on the locus in question. Defining the minimal features that are absolutely required for imprinting would help us to understand how imprinting has evolved mechanistically. Imprinted retrogenes are a subset of imprinted loci that are relatively simple in their genomic organisation, being distinct from large imprinting clusters, and have the potential to be used as tools to address this question. Here, we compare the repeat element content of imprinted retrogene loci with non-imprinted controls that have a similar locus organisation. We observe no significant differences that are conserved between mouse and human, suggesting that the paucity of SINEs and relative abundance of LINEs at imprinted loci reported by others is not a sequence feature universally required for imprinting.

  17. Nemo phosphorylates Eyes absent and enhances output from the Eya-Sine oculis transcriptional complex during Drosophila retinal determination.

    PubMed

    Morillo, Santiago A; Braid, Lorena R; Verheyen, Esther M; Rebay, Ilaria

    2012-05-01

    The retinal determination gene network comprises a collection of transcription factors that respond to multiple signaling inputs to direct Drosophila eye development. Previous genetic studies have shown that nemo (nmo), a gene encoding a proline-directed serine/threonine kinase, can promote retinal specification through interactions with the retinal determination gene network, although the molecular point of cross-talk was not defined. Here, we report that the Nemo kinase positively and directly regulates Eyes absent (Eya). Genetic assays show that Nmo catalytic activity enhances Eya-mediated ectopic eye formation and potentiates induction of the Eya-Sine oculis (So) transcriptional targets dachshund and lozenge. Biochemical analyses demonstrate that Nmo forms a complex with and phosphorylates Eya at two consensus mitogen-activated protein kinase (MAPK) phosphorylation sites. These same sites appear crucial for Nmo-mediated activation of Eya function in vivo. Thus, we propose that Nmo phosphorylation of Eya potentiates its transactivation function to enhance transcription of Eya-So target genes during eye specification and development. PMID:22394486

  18. A mapping method for distributive mixing with diffusion: Interplay between chaos and diffusion in time-periodic sine flow

    NASA Astrophysics Data System (ADS)

    Schlick, Conor P.; Christov, Ivan C.; Umbanhowar, Paul B.; Ottino, Julio M.; Lueptow, Richard M.

    2013-05-01

    We present an accurate and efficient computational method for solving the advection-diffusion equation in time-periodic chaotic flows. The method uses operator splitting, which allows the advection and diffusion steps to be treated independently. Taking advantage of flow periodicity, the advection step is solved using a mapping method, and diffusion is "added" discretely after each iteration of the advection map. This approach results in the construction of a composite mapping matrix over an entire period of the chaotic advection-diffusion process and provides a natural framework for the analysis of mixing. To test the approach, we consider two-dimensional time-periodic sine flow. By comparing the numerical solutions obtained by our method to reference solutions, we find qualitative agreement for large time steps (structure of concentration profile) and quantitative agreement for small time steps (low error). Further, we study the interplay between mixing through chaotic advection and mixing through diffusion leading to an analytical model for the evolution of the intensity of segregation with time. Additionally, we demonstrate that our operator splitting mapping approach can be readily extended to three dimensions.

  19. A swine SINE (PRE-1 sequence) distribution in swine-related animal species and its phylogenetic analysis in swine genome.

    PubMed

    Yasue, H; Wada, Y

    1996-04-01

    The distribution of PRE-1 sequence (a swine SINE) among the animal species related to Sus scrofa, i.e. Phacochoerus aethiopicus and Tayassu tajacu, was examined by dot-blot analysis using PRE-1 sequences as a probe. This revealed that Phacochoerus aethiopicus and Tayassu tajacu contained PRE-1 sequences, amounts of which in their genomes are almost the same as that in the swine genome, indicating that these species separated after PRE-1 sequences proliferated to diversify in the genome. In order to estimate the time when the PRE-1 started to diversify in the swine genome, PRE-1 sequences were extracted from GenBank DNA database by homology analysis using the PRE-1 consensus sequence as a probe. The 22 PRE-1 sequences obtained were aligned and their phylogenetic relation was calculated by the neighbour-joining method. The result of the calculation combined with the mutation rate of the pseudogenes (r = 4.6 x 10(-9)) indicated that the PRE-1 sequence diversified at least 43.2 million years ago. Taken together, the period of time since the separation of the three species, Sus scrofa, Phacochoerus aethiopicus and Tayassu tajacu, is currently estimated to be less than 43.2 million years. PMID:8856898

  20. A novel composite retrotransposon derived from or generated independently of the SVA (SINE/VNTR/Alu) transposon has undergone proliferation in gibbon genomes.

    PubMed

    Hara, Toru; Hirai, Yuriko; Baicharoen, Sudarath; Hayakawa, Takashi; Hirai, Hirohisa; Koga, Akihiko

    2012-01-01

    The superfamily Hominoidea (hominoids) comprises two families: Hominidae (hominids) and Hylobatidae (gibbons, also called small apes). The SVA transposon is a composite retrotransposon that occurs widely in hominoids and is considered to have been generated by stepwise fusions of three genetic elements: SINE-R, a variable number of tandem repeat (VNTR) sequence, and Alu. We identified a novel transposon whose basic structure is the same as that of SVA, with one prominent difference being the presence of part of prostaglandin reductase 2 (PTGR2) in place of SINE-R. We designate this composite transposon as PVA and propose two possible mechanisms regarding its generation. One is the derivation of PVA from SVA: the SINE-R region of SVA was replaced with a PTGR2 fragment by template switching. The other is the formation of PVA independently of SVA: a PTGR2 fragment was fused to an evolutionary intermediate comprising the VNTR and Alu regions. The nucleotide sequence of the junction between the VNTR and PTGR2 regions supports the second hypothesis. We identified PVA in the white-cheeked gibbon Nomascus leucogenys by analysis of genome sequence databases, and subsequent experimental analysis revealed its presence in all four gibbon genera. The white-cheeked gibbon harbors at least 93 PVA copies in its haploid genome. Another SVA-like composite transposon carrying parts of the LINE1 and Alu transposons in place of SINE-R, designated as LAVA, has recently been reported. The significance of the discovery of PVA is that its substituted fragment originates not from a transposon but from a single-copy gene. PVA should provide additional insights into the transposition mechanism of this type of composite transposon; the transposition activity is conferred even if the substituted fragment is not related to a transposon.

  1. A RAB3GAP1 SINE Insertion in Alaskan Huskies with Polyneuropathy, Ocular Abnormalities, and Neuronal Vacuolation (POANV) Resembling Human Warburg Micro Syndrome 1 (WARBM1).

    PubMed

    Wiedmer, Michaela; Oevermann, Anna; Borer-Germann, Stephanie E; Gorgas, Daniela; Shelton, G Diane; Drögemüller, Michaela; Jagannathan, Vidhya; Henke, Diana; Leeb, Tosso

    2015-11-23

    We observed a hereditary phenotype in Alaskan Huskies that was characterized by polyneuropathy with ocular abnormalities and neuronal vacuolation (POANV). The affected dogs developed a progressive severe ataxia, which led to euthanasia between 8 and 16 months of age. The pedigrees were consistent with a monogenic autosomal recessive inheritance. We localized the causative genetic defect to a 4 Mb interval on chromosome 19 by a combined linkage and homozygosity mapping approach. Whole genome sequencing of one affected dog, an obligate carrier, and an unrelated control revealed a 218-bp SINE insertion into exon 7 of the RAB3GAP1 gene. The SINE insertion was perfectly associated with the disease phenotype in a cohort of 43 Alaskan Huskies, and it was absent from 541 control dogs of diverse other breeds. The SINE insertion induced aberrant splicing and led to a transcript with a greatly altered exon 7. RAB3GAP1 loss-of-function variants in humans cause Warburg Micro Syndrome 1 (WARBM1), which is characterized by additional developmental defects compared to canine POANV, whereas Rab3gap1-deficient mice have a much milder phenotype than either humans or dogs. Thus, the RAB3GAP1 mutant Alaskan Huskies provide an interesting intermediate phenotype that may help to better understand the function of RAB3GAP1 in development. Furthermore, the identification of the presumed causative genetic variant will enable genetic testing to avoid the nonintentional breeding of affected dogs.

  2. Strength Analysis of Sandwitch Panels with CFRP Quasi Isotropic Layup or Isotropic Material Facesheets in Dynamic Environment Using MSC Nastran and SineMOS

    NASA Astrophysics Data System (ADS)

    Di Carlo, A.; Carbonell Garcia, A.

    2012-07-01

    The frequency response solution (SOL 111) of MSC Nastran versions prior to 2012 only allows the output of element stress components and element forces and does not allow the calculation of composite failure indices or Von-Mises stress for metallic parts. The analysis of a sandwich panel comprises several strength verifications, such as the check of facesheet and core failure as well as the check of facesheet and core local stability (shear crimping, wrinkling). In static analysis (SOL 101), MSC Nastran provides failure index output which can be used to generate fringe plots of Margins of Safety (MoS) in any post- processing tool. The other verifications (core strength and local stability) must be performed using different tools. For the dynamic analysis of sandwich panels, an analysis technique based on element forces and on failure envelope at laminate level has been developed and implemented in a Fortran program (SineMOS) which allows evaluating facesheet and core failure as well as local stability, taking into account modulus and phase information of the element forces. SineMOS is able to produce files containing information used to generate plots of minimum Margin of Safety in Patran for each failure mode. This paper shows the various steps of the analysis process, starting from the building of the failure envelope for the CFRP facesheet laminate. Finally some validation example is shown, comparing SineMOS results with results based on the application of static displacements to the nodes of the model.

  3. A RAB3GAP1 SINE Insertion in Alaskan Huskies with Polyneuropathy, Ocular Abnormalities, and Neuronal Vacuolation (POANV) Resembling Human Warburg Micro Syndrome 1 (WARBM1).

    PubMed

    Wiedmer, Michaela; Oevermann, Anna; Borer-Germann, Stephanie E; Gorgas, Daniela; Shelton, G Diane; Drögemüller, Michaela; Jagannathan, Vidhya; Henke, Diana; Leeb, Tosso

    2016-02-01

    We observed a hereditary phenotype in Alaskan Huskies that was characterized by polyneuropathy with ocular abnormalities and neuronal vacuolation (POANV). The affected dogs developed a progressive severe ataxia, which led to euthanasia between 8 and 16 months of age. The pedigrees were consistent with a monogenic autosomal recessive inheritance. We localized the causative genetic defect to a 4 Mb interval on chromosome 19 by a combined linkage and homozygosity mapping approach. Whole genome sequencing of one affected dog, an obligate carrier, and an unrelated control revealed a 218-bp SINE insertion into exon 7 of the RAB3GAP1 gene. The SINE insertion was perfectly associated with the disease phenotype in a cohort of 43 Alaskan Huskies, and it was absent from 541 control dogs of diverse other breeds. The SINE insertion induced aberrant splicing and led to a transcript with a greatly altered exon 7. RAB3GAP1 loss-of-function variants in humans cause Warburg Micro Syndrome 1 (WARBM1), which is characterized by additional developmental defects compared to canine POANV, whereas Rab3gap1-deficient mice have a much milder phenotype than either humans or dogs. Thus, the RAB3GAP1 mutant Alaskan Huskies provide an interesting intermediate phenotype that may help to better understand the function of RAB3GAP1 in development. Furthermore, the identification of the presumed causative genetic variant will enable genetic testing to avoid the nonintentional breeding of affected dogs. PMID:26596647

  4. A RAB3GAP1 SINE Insertion in Alaskan Huskies with Polyneuropathy, Ocular Abnormalities, and Neuronal Vacuolation (POANV) Resembling Human Warburg Micro Syndrome 1 (WARBM1)

    PubMed Central

    Wiedmer, Michaela; Oevermann, Anna; Borer-Germann, Stephanie E.; Gorgas, Daniela; Shelton, G. Diane; Drögemüller, Michaela; Jagannathan, Vidhya; Henke, Diana; Leeb, Tosso

    2015-01-01

    We observed a hereditary phenotype in Alaskan Huskies that was characterized by polyneuropathy with ocular abnormalities and neuronal vacuolation (POANV). The affected dogs developed a progressive severe ataxia, which led to euthanasia between 8 and 16 months of age. The pedigrees were consistent with a monogenic autosomal recessive inheritance. We localized the causative genetic defect to a 4 Mb interval on chromosome 19 by a combined linkage and homozygosity mapping approach. Whole genome sequencing of one affected dog, an obligate carrier, and an unrelated control revealed a 218-bp SINE insertion into exon 7 of the RAB3GAP1 gene. The SINE insertion was perfectly associated with the disease phenotype in a cohort of 43 Alaskan Huskies, and it was absent from 541 control dogs of diverse other breeds. The SINE insertion induced aberrant splicing and led to a transcript with a greatly altered exon 7. RAB3GAP1 loss-of-function variants in humans cause Warburg Micro Syndrome 1 (WARBM1), which is characterized by additional developmental defects compared to canine POANV, whereas Rab3gap1-deficient mice have a much milder phenotype than either humans or dogs. Thus, the RAB3GAP1 mutant Alaskan Huskies provide an interesting intermediate phenotype that may help to better understand the function of RAB3GAP1 in development. Furthermore, the identification of the presumed causative genetic variant will enable genetic testing to avoid the nonintentional breeding of affected dogs. PMID:26596647

  5. Mathematical modelling of tsunami impacts on critical infrastructures: exposure and severity associated with debris transport at Sines port, Portugal.

    NASA Astrophysics Data System (ADS)

    Conde, Daniel; Baptista, Maria Ana; Sousa Oliveira, Carlos; Ferreira, Rui M. L.

    2015-04-01

    Global energy production is still significantly dependant on the coal supply chain, justifying huge investments on building infrastructures, capable of stocking very large quantities of this natural resource. Most of these infrastructures are located at deep-sea ports and are therefore exposed to extreme coastal hazards, such as tsunami impacts. The 2011 Tohoku tsunami is reported to have inflicted severe damage to Japan's coal-fired power stations and related infrastructure. Sines, located in the Portuguese coast, hosts a major commercial port featuring an exposed coal stockpile area extending over more than 24 ha and a container terminal currently under expansion up to 100ha. It is protected against storm surges but tsunamis have not been considered in the design criteria. The dominant wind-generated wave direction is N to NW, while the main tsunamigenic faults are located S to SW of the port. This configuration potentially exposes sensitive facilities, such as the new terminal container and the coal stockpile area. According to a recent revision of the national tsunami catalogue (Baptista, 2009), Portugal has been affected by numerous major tsunamis over the last two millennia, with the most notorious event being the Great Lisbon Earthquake and Tsunami occurred on the 1st November 1755. The aim of this work is to simulate the open ocean propagation and overland impact of a tsunami on the Sines port, similar to the historical event of 1755, based on the different tsunamigenic faults and magnitudes proposed in the current literature. Open ocean propagation was modelled with standard simulation tools like TUNAMI and GeoClaw. Near-shore and overland propagation was carried out using a recent 2DH mathematical model for solid-fluid flows, STAV-2D from CERIS-IST (Ferreira et al., 2009; Canelas, 2013). STAV-2D is particularly suited for tsunami propagation over complex and morphodynamic geometries, featuring a discretization scheme based on a finite-volume method using

  6. Cost reduction and manufacture of the SunSine{reg_sign} AC module: Phase I Annual Report : 21 April 1998 -- 31 October 1999

    SciTech Connect

    Kern, E.; Kern, G.

    2000-03-06

    This report summarizes the progress made by Ascension Technology in Phase 1 of the cost reduction and manufacturing improvements of the SunSine{reg_sign} AC Module. This work, conducted under NREL subcontract, is a two-phase effort consisting of investigations into improving inverter packaging, soft switching, circuit optimization, design for manufacturing, manufacturing processes, and pilot production manufacturing. The objective of this subcontract is to significantly reduce the cost of the SunSine{reg_sign} inverter, enhance its performance, and streamline and expand the manufacturing process. During Phase 1, the soft-switching topology was designed, then refined to meet stringent cost and performance goals. This design resulted in improved performance, smaller overall footprint, and reduced costs. The aluminum inverter housing was redesigned, and the decision was made to conformal coat the circuit boards, which was verified through the HAST (Highly Accelerated Stress Testing) method. Potential international markets were identified, and the inverter is designed to be easily modified to meet the requirements of other countries. Significant cost reduction and performance improvements have been achieved in Phase I, and accomplishments during Phase I include: (1) SunSine{reg_sign} AC Module costs have been reduced enough to be able to reduce the suggested list price; (2) successful implementation of soft-switching; (3) power circuit-board size reduced 53{percent}; (4) power circuit-board component count reduced 34{percent}; (5) total inverter parts count reduced 49{percent}; (6) anticipated inverter manufacturing cost reduced 57{percent} on a $/Wp rating; (7) transformer efficiency improved 1.4{percent}; and (8) inverter efficiency improved 4.7{percent} to 91.0{percent} at 275 Wac.

  7. Plasma column displacement measurements by modified Rogowski sine-coil and Biot-Savart/magnetic flux equation solution on IR-T1 tokamak

    SciTech Connect

    Razavi, M.; Mollai, M.; Khorshid, P.; Nedzelskiy, I.; Ghoranneviss, M.

    2010-05-15

    The modified Rogowski sine-coil (MRSC) has been designed and implemented for the plasma column horizontal displacement measurements on small IR-T1 tokamak. MRSC operation has been examined on test assembly and tokamak. Obtained results show high sensitivity to the plasma column horizontal displacement and negligible sensitivity to the vertical displacement; linearity in wide, {+-}0.1 m, range of the displacements; and excellent, 1.5%, agreement with the results of numerical solution of Biot-Savart and magnetic flux equations.

  8. Mathematical modelling of tsunami impacts on critical infrastructures: exposure and severity associated with debris transport at Sines port, Portugal.

    NASA Astrophysics Data System (ADS)

    Conde, Daniel; Baptista, Maria Ana; Sousa Oliveira, Carlos; Ferreira, Rui M. L.

    2015-04-01

    Global energy production is still significantly dependant on the coal supply chain, justifying huge investments on building infrastructures, capable of stocking very large quantities of this natural resource. Most of these infrastructures are located at deep-sea ports and are therefore exposed to extreme coastal hazards, such as tsunami impacts. The 2011 Tohoku tsunami is reported to have inflicted severe damage to Japan's coal-fired power stations and related infrastructure. Sines, located in the Portuguese coast, hosts a major commercial port featuring an exposed coal stockpile area extending over more than 24 ha and a container terminal currently under expansion up to 100ha. It is protected against storm surges but tsunamis have not been considered in the design criteria. The dominant wind-generated wave direction is N to NW, while the main tsunamigenic faults are located S to SW of the port. This configuration potentially exposes sensitive facilities, such as the new terminal container and the coal stockpile area. According to a recent revision of the national tsunami catalogue (Baptista, 2009), Portugal has been affected by numerous major tsunamis over the last two millennia, with the most notorious event being the Great Lisbon Earthquake and Tsunami occurred on the 1st November 1755. The aim of this work is to simulate the open ocean propagation and overland impact of a tsunami on the Sines port, similar to the historical event of 1755, based on the different tsunamigenic faults and magnitudes proposed in the current literature. Open ocean propagation was modelled with standard simulation tools like TUNAMI and GeoClaw. Near-shore and overland propagation was carried out using a recent 2DH mathematical model for solid-fluid flows, STAV-2D from CERIS-IST (Ferreira et al., 2009; Canelas, 2013). STAV-2D is particularly suited for tsunami propagation over complex and morphodynamic geometries, featuring a discretization scheme based on a finite-volume method using

  9. Receiver Signal to Noise Ratios for IPDA Lidars Using Sine-wave and Pulsed Laser Modulation and Direct Detections

    NASA Technical Reports Server (NTRS)

    Sun, Xiaoli; Abshire, James B.

    2011-01-01

    seeder lasers, one on-line and one offline that are intensity modulated by two different frequency sine-waves signals before being amplified by a common laser amplifier. The receiver uses narrowband amplitude demodulation, or lock-in, Signal processing at the given laser modulation frequencies [3,4]. The laser transmitter operates in a quasi CW mode with the peak power equal to twice the average power. The on-line and off-line lasers can be transmitted at the same time without interference. Another direct detection technique uses a low duty cycle pulsed laser modulation [5,6] with the laser wavelengths alternating between on-line and off-line on successive pulses. The receiver uses time resolved detection and can also provide simultaneous target range measurement. With a lower laser duty cycle it requires a much higher peak laser power for the same average power.

  10. Modal analysis of low-level-light aiming sight-glass based on shock testing conditions

    NASA Astrophysics Data System (ADS)

    Gao, Youtang; Ding, Huan; Xue, Xiao; Xu, Yuan; Chang, Benkang

    2010-10-01

    Low-level-light ( LLL ) aiming sight-glass measurement technologies based on multiple circumstances testing conditions are always concerned by military equipments manufacturers. The article puts forward the concrete steps and method of shock circumstances testing measurement according to military optical equipments circumstances testing standard. Using shock theory and mathematical modeling analysis, shock model of LLL aiming sight-glass based on shock testing conditions is constructed and analyzed. Without considering resistances and under instantaneous half-sine shock pulse, the ratio of system response amplitude and half-sine pulse peak value is related to system inherent characteristic (inherent frequency, cycle T, etc.) and shock pulse duration D. The results indicate that given D/T>~ 10.5, / 1 max / A = , half-sine shock pulse is transmitted by 1:1. Testing device response acceleration is equal to shock pulse peak acceleration. Testing device response is more intense under this condition. LLL aiming sight-glass structural performance and reticle zero point moving are influenced. Optical lens offset of LLL aiming sight-glass testing parts is impacted. Optical path parameters change and light transmission is influenced. What is more serious is that objective lens will be broken due to shock pulse transmission.

  11. Electrical resistance tomography with constrained sine wave solutions for impact damage identification in glass fiber/epoxy/carbon black laminate composites

    NASA Astrophysics Data System (ADS)

    Tallman, T. N.

    2016-04-01

    Electrical impedance tomography (EIT) has incredible potential for structural health monitoring (SHM) when applied to structures in which mechanical damage is coupled with changes in electrical conductivity. Practically, however, the potential of EIT for SHM is largely nullified by requiring both non-negligible computational resources and accurate initial conductivity estimates. By working in resistivity instead of conductivity and constraining the change in resistivity to be a series of two-dimensional sine waves, a novel resistivity-based EIT formulation is herein developed that significantly abates the computational requirements of EIT and is independent of initial estimates. This approach is explored analytically and then demonstrated experimentally by locating impact damage to a glass fiber/epoxy/carbon black laminate.

  12. Sine-Gordon Equation in (1+2) and (1+3) dimensions: Existence and Classification of Traveling-Wave Solutions.

    PubMed

    Zarmi, Yair

    2015-01-01

    The (1+1)-dimensional Sine-Gordon equation passes integrability tests commonly applied to nonlinear evolution equations. Its kink solutions (one-dimensional fronts) are obtained by a Hirota algorithm. In higher space-dimensions, the equation does not pass these tests. Although it has been derived over the years for quite a few physical systems that have nothing to do with Special Relativity, the Sine-Gordon equation emerges as a non-linear relativistic wave equation. This opens the way for exploiting the tools of the Theory of Special Relativity. Using no more than the relativistic kinematics of tachyonic momentum vectors, from which the solutions are constructed through the Hirota algorithm, the existence and classification of N-moving-front solutions of the (1+2)- and (1+3)-dimensional equations for all N ≥ 1 are presented. In (1+2) dimensions, each multi-front solution propagates rigidly at one velocity. The solutions are divided into two subsets: Solutions whose velocities are lower than a limiting speed, c = 1, or are greater than or equal to c. To connect with concepts of the Theory of Special Relativity, c will be called "the speed of light." In (1+3)-dimensions, multi-front solutions are characterized by spatial structure and by velocity composition. The spatial structure is either planar (rotated (1+2)-dimensional solutions), or genuinely three-dimensional--branes. Planar solutions, propagate rigidly at one velocity, which is lower than, equal to, or higher than c. Branes must contain clusters of fronts whose speed exceeds c = 1. Some branes are "hybrids": different clusters of fronts propagate at different velocities. Some velocities may be lower than c but some must be equal to, or exceed, c. Finally, the speed of light cannot be approached from within the subset of slower-than-light solutions in both (1+2) and (1+3) dimensions.

  13. Sine-Gordon Equation in (1+2) and (1+3) dimensions: Existence and Classification of Traveling-Wave Solutions.

    PubMed

    Zarmi, Yair

    2015-01-01

    The (1+1)-dimensional Sine-Gordon equation passes integrability tests commonly applied to nonlinear evolution equations. Its kink solutions (one-dimensional fronts) are obtained by a Hirota algorithm. In higher space-dimensions, the equation does not pass these tests. Although it has been derived over the years for quite a few physical systems that have nothing to do with Special Relativity, the Sine-Gordon equation emerges as a non-linear relativistic wave equation. This opens the way for exploiting the tools of the Theory of Special Relativity. Using no more than the relativistic kinematics of tachyonic momentum vectors, from which the solutions are constructed through the Hirota algorithm, the existence and classification of N-moving-front solutions of the (1+2)- and (1+3)-dimensional equations for all N ≥ 1 are presented. In (1+2) dimensions, each multi-front solution propagates rigidly at one velocity. The solutions are divided into two subsets: Solutions whose velocities are lower than a limiting speed, c = 1, or are greater than or equal to c. To connect with concepts of the Theory of Special Relativity, c will be called "the speed of light." In (1+3)-dimensions, multi-front solutions are characterized by spatial structure and by velocity composition. The spatial structure is either planar (rotated (1+2)-dimensional solutions), or genuinely three-dimensional--branes. Planar solutions, propagate rigidly at one velocity, which is lower than, equal to, or higher than c. Branes must contain clusters of fronts whose speed exceeds c = 1. Some branes are "hybrids": different clusters of fronts propagate at different velocities. Some velocities may be lower than c but some must be equal to, or exceed, c. Finally, the speed of light cannot be approached from within the subset of slower-than-light solutions in both (1+2) and (1+3) dimensions. PMID:26020922

  14. Design of three-mirror telescopes via a differential equation method

    NASA Astrophysics Data System (ADS)

    Chao, Shao-Hua; Evans, Neal C.; Shealy, David L.; Johnson, R. Barry

    1996-11-01

    A differential equation method is applied to the design of a three-mirror telescope. The resulting system is mostly free of spherical aberration, coma and astigmatism. From caustic theory and a generalization of the Coddington Equations, the Abbe sine condition and the constant optical path length condition, three coupled differential equations, one for each reflecting surface, are generated. A system which satisfies these conditions will have a high resolution over a wide field of view. Analysis of this application is presented as a comparison to a similar three-mirror telescope system produced by conventional optimization techniques.

  15. Recent evolutionary acquisition of alternative pre-mRNA splicing and 3' processing regulations induced by intronic B2 SINE insertion.

    PubMed Central

    Michel, D; Chatelain, G; Mauduit, C; Benahmed, M; Brun, G

    1997-01-01

    Contrary to the membrane-anchored leukemia inhibitory factor receptor (LIFR), the mouse soluble LIFR is an inhibitor of LIF action, possibly through a ligand titration effect. Two mRNA species encoding the soluble LIFR have been identified. Since the 3'-untranslated end of the shorter form was shown to contain a B2 element, we have examined the possibility that this SINE may be responsible for LIFR mRNA truncation. Transient expression assays, using B2-derived or intron-derived sequences independently or in conjunction, show that the B2 element has fortuitously unmasked a cryptic pre-mRNA 3'processing activity of silent intron sequences. The corresponding locus of the rat genome has been isolated and was shown to be devoid of any retroposon, which may explain why no soluble LIFR has yet been identified in any other species and further indicates that the B2 insertion event in the mouse LIFR gene has occurred recently during evolution. And yet, a tight tissue-specific regulation of alternative synthesis of soluble and membrane-bound LIFR mRNA has already emerged in mice. These results provide striking evidence for the rapid influence of retroposition on genome expression. PMID:9241235

  16. Sine-wave electrical stimulation initiates a voltage-gated potassium channel-dependent soft tissue response characterized by induction of hemocyte recruitment and collagen deposition.

    PubMed

    Franklin, Brandon M; Maroudas, Eleni; Osborn, Jeffrey L

    2016-06-01

    Soft tissue repair is a complex process that requires specific communication between multiple cell types to orchestrate effective restoration of physiological functions. Macrophages play a critical role in this wound healing process beginning at the onset of tissue injury. Understanding the signaling mechanisms involved in macrophage recruitment to the wound site is an essential step for developing more effective clinical therapies. Macrophages are known to respond to electrical fields, but the underlying cellular mechanisms mediating this response is unknown. This study demonstrated that low-amplitude sine-wave electrical stimulation (ES) initiates a soft tissue response in the absence of injury in Procambarus clarkii This cellular response was characterized by recruitment of macrophage-like hemocytes to the stimulation site indicated by increased hemocyte density at the site. ES also increased tissue collagen deposition compared to sham treatment (P < 0.05). Voltage-gated potassium (KV) channel inhibition with either 4-aminopyridine or astemizole decreased both hemocyte recruitment and collagen deposition compared to saline infusion (P < 0.05), whereas inhibition of calcium-permeable channels with ruthenium red did not affect either response to ES Thus, macrophage-like hemocytes in P. clarkii elicit a wound-like response to exogenous ES and this is accompanied by collagen deposition. This response is mediated by KV channels but independent of Ca(2+) channels. We propose a significant role for KV channels that extends beyond facilitating Ca(2+) transport via regulation of cellular membrane potentials during ES of soft tissue.

  17. Color image encryption by using Yang-Gu mixture amplitude-phase retrieval algorithm in gyrator transform domain and two-dimensional Sine logistic modulation map

    NASA Astrophysics Data System (ADS)

    Sui, Liansheng; Liu, Benqing; Wang, Qiang; Li, Ye; Liang, Junli

    2015-12-01

    A color image encryption scheme is proposed based on Yang-Gu mixture amplitude-phase retrieval algorithm and two-coupled logistic map in gyrator transform domain. First, the color plaintext image is decomposed into red, green and blue components, which are scrambled individually by three random sequences generated by using the two-dimensional Sine logistic modulation map. Second, each scrambled component is encrypted into a real-valued function with stationary white noise distribution in the iterative amplitude-phase retrieval process in the gyrator transform domain, and then three obtained functions are considered as red, green and blue channels to form the color ciphertext image. Obviously, the ciphertext image is real-valued function and more convenient for storing and transmitting. In the encryption and decryption processes, the chaotic random phase mask generated based on logistic map is employed as the phase key, which means that only the initial values are used as private key and the cryptosystem has high convenience on key management. Meanwhile, the security of the cryptosystem is enhanced greatly because of high sensitivity of the private keys. Simulation results are presented to prove the security and robustness of the proposed scheme.

  18. An Alternative Strategy of Preventive Control of Tick-Borne Relapsing Fever in Rural Areas of Sine-Saloum, Senegal.

    PubMed

    Diatta, Georges; Mediannikov, Oleg; Boyer, Sylvie; Sokhna, Cheikh; Bassène, Hubert; Fenollar, Florence; Chauvancy, Gilles; Ndiaye, Abdoul Aziz; Diene, Fatoumata; Parola, Philippe; Raoult, Didier

    2016-09-01

    In Senegal, tick-borne relapsing fever (TBRF) is a major cause of morbidity and a neglected public health problem. Borreliosis cases commonly detected in two villages led us to implement a borreliosis preventive control including cementing of floors in bedrooms and outbuildings attended by inhabitants to avoid human contacts with tick vectors. Epidemiological and medical monitoring of the TBRF incidence was carried out at Dielmo and Ndiop by testing the blood of febrile patients since 1990 and 1993, respectively. Intra-domiciliary habitat conditions were improved by cementing, coupled with accompanying measures, from March 2013 to September 2015. Application of this strategy was associated with a significant reduction of borreliosis incidence. This was more evident in Dielmo, dropping from 10.55 to 2.63 cases per 100 person-years (P < 0.001), than in Ndiop where it changed from 3.79 to 1.39 cases per 100 person-years (P < 0.001). Thirty-six cases of TBRF were estimated to be prevented at a cost of €526 per infection. The preventive control strategy was successful in Dielmo and Ndiop, being associated with decreased incidence by 89.8% and 81.5%, respectively, suggesting that TBRF may be widely decreased when the population is involved. Public health authorities or any development stakeholders should adopt this effective tool for promoting rural health through national prevention programs. PMID:27430543

  19. Variant of the anastigmatic telescope with three mirrors for back focal length.

    PubMed

    Herrera, J; Vázquez, S; Luna, E; Salas, L; Nuñez, J; Sohn, E; Ruiz, E

    2011-05-01

    In this paper, an optical design is presented for an anastigmatic telescope with back focal length corrected with exact ray tracing to eliminate spherical, coma, and astigmatism aberrations. The telescope is formed of three conical mirrors, two of them polished on the same substratum. The optical design is divided into three stages: we began the design obtaining the Gaussian parameters in a first-order solution; posteriorly, were obtained analytically the three mirrors' asphericity in a third-order design. The final design stage consists of the implementation of the Fermat's principle, the Abbe sine condition, and the Coddington equations for the exact correction for the three aforementioned aberrations. PMID:21532673

  20. Geostatistical uncertainty of assessing air quality using high-spatial-resolution lichen data: A health study in the urban area of Sines, Portugal.

    PubMed

    Ribeiro, Manuel C; Pinho, P; Branquinho, C; Llop, Esteve; Pereira, Maria J

    2016-08-15

    In most studies correlating health outcomes with air pollution, personal exposure assignments are based on measurements collected at air-quality monitoring stations not coinciding with health data locations. In such cases, interpolators are needed to predict air quality in unsampled locations and to assign personal exposures. Moreover, a measure of the spatial uncertainty of exposures should be incorporated, especially in urban areas where concentrations vary at short distances due to changes in land use and pollution intensity. These studies are limited by the lack of literature comparing exposure uncertainty derived from distinct spatial interpolators. Here, we addressed these issues with two interpolation methods: regression Kriging (RK) and ordinary Kriging (OK). These methods were used to generate air-quality simulations with a geostatistical algorithm. For each method, the geostatistical uncertainty was drawn from generalized linear model (GLM) analysis. We analyzed the association between air quality and birth weight. Personal health data (n=227) and exposure data were collected in Sines (Portugal) during 2007-2010. Because air-quality monitoring stations in the city do not offer high-spatial-resolution measurements (n=1), we used lichen data as an ecological indicator of air quality (n=83). We found no significant difference in the fit of GLMs with any of the geostatistical methods. With RK, however, the models tended to fit better more often and worse less often. Moreover, the geostatistical uncertainty results showed a marginally higher mean and precision with RK. Combined with lichen data and land-use data of high spatial resolution, RK is a more effective geostatistical method for relating health outcomes with air quality in urban areas. This is particularly important in small cities, which generally do not have expensive air-quality monitoring stations with high spatial resolution. Further, alternative ways of linking human activities with their

  1. Origin and speciation of haplochromine fishes in East African crater lakes investigated by the analysis of their mtDNA, Mhc genes, and SINEs.

    PubMed

    Sato, Akie; Takezaki, Naoko; Tichy, Herbert; Figueroa, Felipe; Mayer, Werner E; Klein, Jan

    2003-09-01

    The Western Branch of the East African Great Rift Valley is pocketed with craters of extinct or dormant volcanoes. Many of the craters are filled with water, and the lakes are inhabited by fishes. The objective of the present study was to determine the amount and nature of genetic variation in haplochromine fishes inhabiting two of these crater lakes, Lake Lutoto and Lake Nshere, and to use this information to infer the origin and history of the two populations. To this end, sequences of mitochondrial (mt) DNA control region, exon 2 of major histocompatibility complex (Mhc) class II B genes, and short interspersed elements (SINEs) were analyzed. The results indicate that the Lake Nshere and Lake Lutoto fishes originated from different but related large founding populations derived from the Kazinga Channel, which connects Lake Edward and Lake George. Some of the genetic polymorphism that existed in the ancestral populations was lost in the populations of the two lakes. The polymorphism that has been retained has persisted for some 50000 generations (years). During this time, new mutations arose and became fixed in each of the two populations in the mtDNA, giving rise to sets of diagnostic substitutions. Each population evolved in isolation after the colonization of the lakes less than 50000 years ago. There appears to be no population structure within the crater lake fishes, and their present effective population sizes are in the order of 104 to 105 individuals. Comparisons with the endemic haplochromine species of Lake Victoria reveal interesting parallels, as well as differences, which may help to understand the nature of the speciation process.

  2. Sine-wave electrical stimulation initiates a voltage-gated potassium channel-dependent soft tissue response characterized by induction of hemocyte recruitment and collagen deposition.

    PubMed

    Franklin, Brandon M; Maroudas, Eleni; Osborn, Jeffrey L

    2016-06-01

    Soft tissue repair is a complex process that requires specific communication between multiple cell types to orchestrate effective restoration of physiological functions. Macrophages play a critical role in this wound healing process beginning at the onset of tissue injury. Understanding the signaling mechanisms involved in macrophage recruitment to the wound site is an essential step for developing more effective clinical therapies. Macrophages are known to respond to electrical fields, but the underlying cellular mechanisms mediating this response is unknown. This study demonstrated that low-amplitude sine-wave electrical stimulation (ES) initiates a soft tissue response in the absence of injury in Procambarus clarkii This cellular response was characterized by recruitment of macrophage-like hemocytes to the stimulation site indicated by increased hemocyte density at the site. ES also increased tissue collagen deposition compared to sham treatment (P < 0.05). Voltage-gated potassium (KV) channel inhibition with either 4-aminopyridine or astemizole decreased both hemocyte recruitment and collagen deposition compared to saline infusion (P < 0.05), whereas inhibition of calcium-permeable channels with ruthenium red did not affect either response to ES Thus, macrophage-like hemocytes in P. clarkii elicit a wound-like response to exogenous ES and this is accompanied by collagen deposition. This response is mediated by KV channels but independent of Ca(2+) channels. We propose a significant role for KV channels that extends beyond facilitating Ca(2+) transport via regulation of cellular membrane potentials during ES of soft tissue. PMID:27335435

  3. Ultrasonic anemometer angle of attack errors under turbulent conditions

    NASA Astrophysics Data System (ADS)

    Nakai, T.

    2009-12-01

    Measurements of eddy fluxes are premised on the assumption that wind speeds are measured accurately by an ultrasonic anemometer. Recently, ultrasonic anemometers have been shown to suffer errors depending on the angle of attack, which is the angle between the wind vector and the horizontal. The correction of these errors resulted in general increases in eddy fluxes. However, since the check of the angle of attack dependent error was carried out in the wind tunnel experiment, which would be under the condition of nearly laminar flow, the applicability of this correction to the field data under turbulent conditions has been questioned. In this study, angle of attack dependencies of wind speeds measured by Gill Windmaster ultrasonic anemometers were assessed by field experiment over meadow, considered to be turbulent conditions. By using five identical anemometers, two pairs of systems were prepared: two anemometers for references and one between them for tilt. The dependencies of (co)sine responses of anemometers on angles of attack of 0 to -90 degrees in 10-degree steps and 45 degrees were checked, and clarified that the angle of attack dependent errors occur also under turbulent conditions, with results similar to the wind tunnel experiments. Sine responses of vertical wind speeds depended not only on vertical angle of attack but also on horizontal wind direction, which had not been considered in previous studies. For more robust correction, alternative calibration functions were obtained empirically so as to reasonably explain our field experimental results. Applying this new correction, eddy fluxes increased substantially even over meadow, which is somewhat aerodynamically smooth compared with forests or agricultural fields.

  4. Chromosomal Conditions

    MedlinePlus

    ... 150 babies is born with a chromosomal condition. Down syndrome is an example of a chromosomal condition. Because ... all pregnant women be offered prenatal tests for Down syndrome and other chromosomal conditions. A screening test is ...

  5. A high precision radiation-tolerant LVDT conditioning module

    NASA Astrophysics Data System (ADS)

    Masi, A.; Danzeca, S.; Losito, R.; Peronnard, P.; Secondo, R.; Spiezia, G.

    2014-05-01

    Linear variable differential transformer (LVDT) position sensors are widely used in particle accelerators and nuclear plants, thanks to their properties of contact-less sensing, radiation tolerance, infinite resolution, good linearity and cost efficiency. Many applications require high reading accuracy, even in environments with high radiation levels, where the conditioning electronics must be located several hundred meters away from the sensor. Sometimes even at long distances the conditioning module is still exposed to ionizing radiation. Standard off-the-shelf electronic conditioning modules offer limited performances in terms of reading accuracy and long term stability already with short cables. A radiation tolerant stand-alone LVDT conditioning module has been developed using Commercial Off-The-Shelf (COTS) components. The reading of the sensor output voltages is based on a sine-fit algorithm digitally implemented on an FPGA ensuring few micrometers reading accuracy even with low signal-to-noise ratios. The algorithm validation and board architecture are described. A full metrological characterization of the module is reported and radiation tests results are discussed.

  6. Winning Conditions?

    PubMed

    Green, Esther; Moody, Lesley

    2015-01-01

    The authors of the paper, "The Patient Experience in Ontario 2020: What is Possible?", framed both the current state as well as the future of what patient experience might look like in five years. To ensure intention is catalyzed into meaningful change to improve experience and outcomes, we suggest four winning conditions. The first is to change the language; patients are people too, irrespective of their disease or illness; person-centred is inclusive language and ought to be the focus. The second condition is focused on leaders who play a critical role to establish, build and embed person-centred within the organization. The third and fourth winning conditions are building the evidence base and using effective and meaningful engagement, moving beyond advice, to partnership, respectively. Person-centred care is not the flavour of the month, it is here to stay. Ontarians are important actors in the system not only as users of the system but owners as well. To those who might argue that it is costly to do this work, what are the costs to not engage? Are we satisfied not only as administrators, and clinicians, but as patients at some point, to maintain the status quo? PMID:26888319

  7. Evaluation of the short-term sea cliff retreat along the Tróia-Sines Embayed Coast (Costa da Galé sector), using stereo digital aerial images and Bayesian inference

    NASA Astrophysics Data System (ADS)

    Gama, C.; Jalobeanu, A.

    2011-12-01

    Monitoring the sediment budget of coastal systems is essential to understand the costal equilibrium, and is an important aspect to be considered in coastal management. Thus, the identification and the quantitative evaluation of sedimentary sources and sinks are the first steps towards a better understanding of the dynamics of coastal morphology. The Tróia-Sines Embayed Coast (TSEC) in the southwest Portuguese coast corresponds to a continuous sandy beach that extends for approximately 65 km. It is limited at north by the Sado river estuary and at south by the Sines cape. Beaches are discontinuously limited landward by dunes (≈42 km) and by sea cliffs (≈18 km) made of poorly consolidated Plio-Plistocene detrital deposits. Cliff erosion by subaerial processes or gullying is a continuous phenomenon that contributes a significant amount of sediment to the TSEC coastal system, which is what we want to measure. Mainly due to winter rainfall, sea cliffs develop debris fans at the backshore inner limit, therefore we chose to make morphological measurements at one year interval. Thus, two series digital aerial images at 20 cm resolution were acquired in Oct 2008 and July 2009, supported by a collection of ground control points (GCP) to constrain the sensor orientation. Digital aerial stereo image pairs are used as main data source to reconstruct digital surface models (DSM). A new stereo photogrammetric method is used, based on dense disparity maps and Bayesian inference (Jalobeanu et al, 2010 and Jalobeanu, 2011). The originality of this method is in the computation of the spatial distribution of elevation errors in the DSM using stochastic modelling and probabilistic inference, which helps to detect the statistically significant changes in the estimated topography. The difference between the two generated DSMs is used to characterize the variability of the main subaerial beach morphodynamics parameters, such as: i) the alongshore beach configuration; ii) the beach

  8. Operant Conditioning

    PubMed Central

    Staddon, J. E. R.; Cerutti, D. T.

    2005-01-01

    Operant behavior is behavior “controlled” by its consequences. In practice, operant conditioning is the study of reversible behavior maintained by reinforcement schedules. We review empirical studies and theoretical approaches to two large classes of operant behavior: interval timing and choice. We discuss cognitive versus behavioral approaches to timing, the “gap” experiment and its implications, proportional timing and Weber's law, temporal dynamics and linear waiting, and the problem of simple chain-interval schedules. We review the long history of research on operant choice: the matching law, its extensions and problems, concurrent chain schedules, and self-control. We point out how linear waiting may be involved in timing, choice, and reinforcement schedules generally. There are prospects for a unified approach to all these areas. PMID:12415075

  9. Sine-Gordon model coupled with a free scalar field emergent in the low-energy phase dynamics of a mixture of pseudospin-\\frac{1}{2} Bose gases with interspecies spin exchange

    NASA Astrophysics Data System (ADS)

    Ge, Li; Shi, Yu

    2012-10-01

    Using the approach of low-energy effective field theory, the phase diagram is studied for a mixture of two species of pseudospin-\\frac{1}{2} Bose atoms with interspecies spin exchange. There are four mean-field regimes on the parameter plane of ge and gz, where ge is the interspecies spin-exchange interaction strength, while gz is the difference between the interaction strength of interspecies scattering without spin exchange of equal spins and that of unequal spins. Two regimes, with |gz| > |ge|, correspond to ground states with the total spins of the two species parallel or antiparallel along the z direction, and the low-energy excitations are equivalent to those of two-component spinless bosons. The other two regimes, with |ge| > |gz|, correspond to ground states with the total spins of the two species parallel or antiparallel on the xy plane, and the low-energy excitations are described by a sine-Gordon model coupled with a free scalar field, where the effective fields are combinations of the phases of the original four boson fields. In (1 + 1)-dimension, they are described by Kosterlitz-Thouless renormalization group (RG) equations, and there are three sectors in the phase plane of a scaling dimension and a dimensionless parameter proportional to the strength of the cosine interaction, both depending on the densities. The gaps of these elementary excitations are experimental probes of the underlying many-body ground states.

  10. Identification of a short interspersed repetitive element in partially spliced transcripts of the bell pepper (Capsicum annuum) PAP gene: new evolutionary and regulatory aspects on plant tRNA-related SINEs.

    PubMed

    Pozueta-Romero, J; Houlné, G; Schantz, R

    1998-07-01

    In bell pepper, a gene encoding a major plastid-lipid associated protein is expressed as both partially and totally spliced transcripts (respectively PAP2 and PAP1). Although PAP is present as a single-copy gene in the bell pepper genome, Southern blots using PAP2 as a probe revealed multiple homologous copies. Analyses of the intronic sequence of PAP2 showed the existence of a 206bp short interspersed repetitive element (SINE) belonging to the Ts family of retrotransposons (Yoshioka et al., 1993). Comparison with PAP sequences in other Solanaceae species suggested that the structure of the gene is highly conserved: the two introns are inserted at the same position. However, the Ts insertion found in bell pepper is absent in tobacco and tomato. Studies using RT-PCR showed that in these latter species only totally spliced transcripts of PAP are present. On the other hand, RNA analyses of tobacco plants transformed with the bell pepper PAP revealed the presence of both totally and incompletely spliced transcripts. Altogether our results support the hypothesis that the Ts insertion into the first intron of PAP results in a splicing defect of the corresponding pre-mRNA. Based on the presence of peculiar, previously unidentified Ts elements, a possible horizontal transmission of Ts elements from animals to plants is discussed.

  11. A secure double-image sharing scheme based on Shamir's three-pass protocol and 2D Sine Logistic modulation map in discrete multiple-parameter fractional angular transform domain

    NASA Astrophysics Data System (ADS)

    Sui, Liansheng; Duan, Kuaikuai; Liang, Junli

    2016-05-01

    A secure double-image sharing scheme is proposed by using the Shamir's three-pass protocol in the discrete multiple-parameter fractional angular transform domain. First, an enlarged image is formed by assembling two plain images successively in the horizontal direction and scrambled in the chaotic permutation process, in which the sequences of chaotic pairs are generated by the two-dimensional Sine Logistic modulation map. Second, the scrambled image is divided into two components which are used to constitute a complex image. One component is normalized and regarded as the phase part of the complex image as well as other is considered as the amplitude part. Finally, the complex image is shared between the sender and the receiver by using the Shamir's three-pass protocol, in which the discrete multiple-parameter fractional angular transform is used as the encryption function due to its commutative property. The proposed double-image sharing scheme has an obvious advantage that the key management is convenient without distributing the random phase mask keys in advance. Moreover, the security of the image sharing scheme is enhanced with the help of extra parameters of the discrete multiple-parameter fractional angular transform. To the best of our knowledge, this is the first report on integrating the Shamir's three-pass protocol with double-image sharing scheme in the information security field. Simulation results and security analysis verify the feasibility and effectiveness of the proposed scheme.

  12. Exact solutions for a Maxwell-Kalb-Ramond action with dilaton: Localization of massless and massive modes in a sine-Gordon brane-world

    NASA Astrophysics Data System (ADS)

    Christiansen, H. R.; Cunha, M. S.; Tahim, M. O.

    2010-10-01

    We analytically find the exact propagation modes of the electromagnetic and the Kalb-Ramond fields together in a five-dimensional curved space-time. The existence and localization of gauge particles into our four-dimensional world (4D) is studied in detail on a brane-world scenario in which two gauge fields interact with a dilaton and a gravitational background. The coupling to the dilaton is different in each case causing the splitting between gauge spectra. The gauge-field zero-modes and an infinite tower of Kaluza-Klein massive states are analytically obtained. Relevant conditions on the dilaton coupling constant are found in order to identify with precision every finite tensor and vector eigenstate in the theory. An exact quantization condition on the whole mass spectrum, depending on the dilaton coupling constant and the bulk Planck mass, is inherited from the extra-dimension. This allows finding an exact rule to prevent tachyons in the theory and, by the same token, predicting a possible tensor zero-mode in 4D world. We also show that KK massive-modes contributions onto 4D physics are strongly suppressed.

  13. Design of an anastigmat two-mirror microscope

    NASA Astrophysics Data System (ADS)

    Chao, Shao-Hua; Shealy, David L.

    1995-09-01

    The generalized Coddington equations from caustic theory, the Abbe sine condition, and the constant optical path length condition have been used to design two-mirror microscope systems. These two-microscope systems are free of two of the three aberrations -- spherical aberration, coma, or astigmatism, depending on which two of the three design conditions are used. The optical performance of the resulting two-microscope systems has been compared to that of the Schwarzschild microscope and the Head microscope. The goal of this study is to identify design methods for reflective systems which will yield diffraction limited performance for large numerical apertures and fields of view. Also, these design methods are being extended to a three-mirror telescope.

  14. Study on plate silencer with general boundary conditions

    NASA Astrophysics Data System (ADS)

    Liu, Gongmin; Zhao, Xiaochen; Zhang, Wenping; Li, Shuaijun

    2014-09-01

    A plate silencer consists of an expansion chamber with two side-branch rigid cavities covered by plates. Previous studies showed that, in a duct, the introduction of simply supported or clamped plates into an air conveying system could achieve broadband quieting from low to medium frequencies. In this study, analytical formulation is extended to the plate silencer with general boundary conditions. A set of static beam functions, which are a combination of sine series and third-order polynomial, is employed as the trial functions of the plate vibration velocity. Greens function and Kirchhoff-Helmholtz integral are used to solve the sound radiation in the duct and the cavity, and then the vibration velocity of the plate is obtained. Having obtained the vibration velocity, the pressure perturbations induced by the plate oscillation and the transmission loss are found. Optimization is carried out in order to obtain the widest stopband. The transmission loss calculated by the analytical method agrees closely with the result of the finite element method simulation. Further studies with regard to the plate under several different classical boundary conditions based on the validated model show that a clamped-free plate silencer has the worst stopband. Attempts to release the boundary restriction of the plate are also made to study its effect on sound reflection. Results show that a softer end for a clamped-clamped plate silencer helps increase the optimal bandwidth, while the same treatment for simply supported plate silencer will result in performance degradation.

  15. Classical conditioning of autonomic fear responses is independent of contingency awareness.

    PubMed

    Schultz, Douglas H; Helmstetter, Fred J

    2010-10-01

    The role of contingency awareness in classical conditioning experiments using human subjects is currently under debate. This study took a novel approach to manipulating contingency awareness in a differential Pavlovian conditioning paradigm. Complex sine wave gratings were used as visual conditional stimuli (CS). By manipulating the fundamental spatial frequency of the displays, we were able to construct pairs of stimuli that varied in discriminability. One group of subjects was given an "easy" discrimination, and another was exposed to a "difficult" CS+ and CS-. A 3rd group was exposed to a stimulus that was paired with the unconditional stimulus (UCS) 50% of the time and served as a control. Skin conductance response (SCR) and continuous UCS expectancy data were measured concurrently throughout the experiment. Differential UCS expectancy was found only in the easy discrimination group. Differential SCRs were found in the easy discrimination group as well as in the difficult discrimination group, but not in the 50% contingency control. The difficult discrimination group did not exhibit differential UCS expectancy but did show clear differential SCR. These observations support a dual process interpretation of classical conditioning whereby conditioning on an implicit level can occur without explicit knowledge about the contingencies. The role of contingency awareness in classical conditioning experiments using human subjects is currently under debate. This study took a novel approach to manipulating contingency awareness in a differential Pavlovian conditioning paradigm. Complex sine wave gratings were used as visual conditional stimuli (CS). By manipulating the fundamental spatial frequency of the displays, we were able to construct pairs of stimuli that varied in discriminability. One group of subjects was given an "easy" discrimination, and another was exposed to a "difficult" CS+ and CS-. A 3rd group was exposed to a stimulus that was paired with the

  16. Kindling molecules: a new way to `break' the Abbe limit

    NASA Astrophysics Data System (ADS)

    Haeberlé, Olivier

    2004-01-01

    Fluorescence microscopy is a key tool for biological investigations. However, compared to other techniques like electron microscopy, the achievable resolution is still limited. Tremendous efforts have been devoted to improve the resolution of far-field optical microscopy. Several techniques do exist; however their adoption by biologists has been slowed by several technical limitations. We propose a new method based on a recently discovered family of optically switchable fluorescent molecules. Kindling proteins open the way to very high resolution in far-field fluorescence 3-D microscopy with relatively simple techniques. To cite this article: O. Haeberlé, C. R. Physique 5 (2004).

  17. The Hyperbolic Sine Cardinal and the Catenary

    ERIC Educational Resources Information Center

    Sanchez-Reyes, Javier

    2012-01-01

    The hyperbolic function sinh(x)/x receives scant attention in the literature. We show that it admits a clear geometric interpretation as the ratio between length and chord of a symmetric catenary segment. The inverse, together with the use of dimensionless parameters, furnishes a compact, explicit construction of a general catenary segment of…

  18. Quantum complex sine-Gordon dressed boundaries

    NASA Astrophysics Data System (ADS)

    Bowcock, P.; Umpleby, J. M.

    2008-11-01

    In this paper we investigate the quantum reflection factor for the CSG dressed boundary, previously constructed by dressing the Dirichlet boundary with the integrable CSG defect [1]. We analyse classical bound states and use semi-classical methods to investigate the quantum boundary spectrum. We conjecture a fully quantum reflection matrix for a particle reflecting from an unexcited boundary. By using the reflection and boundary bootstrap equations, the reflection matrix for a charge Q = +n soliton reflecting from the mth excited boundary is constructed. Evidence supporting our conjecture is given by checking that the bootstrap closes and that the reflection matrices agrees with known results in the classical limit. A partial analysis of the poles in the reflection matrices which arise from Coleman-Thun diagrams is given.

  19. Allergic Skin Conditions

    MedlinePlus

    American Academy of Allergy Asthma & Immunology Menu Search Main navigation Skip to content Conditions & Treatments Allergies Asthma Primary Immunodeficiency Disease Related Conditions Drug Guide Conditions Dictionary Just ...

  20. Age-related declines in car following performance under simulated fog conditions.

    PubMed

    Ni, Rui; Kang, Julie J; Andersen, George J

    2010-05-01

    The present study examined age-related differences in car following performance when contrast of the driving scene was reduced by simulated fog. Older (mean age of 72.6) and younger (mean age of 21.1) drivers were presented with a car following scenario in a simulator in which a lead vehicle (LV) varied speed according to a sum of three sine wave functions. Drivers were shown an initial following distance of 18 m and were asked to maintain headway distance by controlling speed to match changes in LV speed. Five simulated fog conditions were examined ranging from a no fog condition (contrast of 0.55) to a high fog condition (contrast of 0.03). Average LV speed varied across trials (40, 60, or 80 km/h). The results indicated age-related declines in car following performance for both headway distance and RMS (root mean square) error in matching speed. The greatest decline occurred at moderate speeds under the highest fog density condition, with older drivers maintaining a headway distance that was 21% closer than younger drivers. At higher speeds older drivers maintained a greater headway distance than younger drivers. These results suggest that older drivers may be at greater risk for a collision under high fog density and moderate speeds.

  1. Simultaneous backward conditioned inhibition and mediated conditioning.

    PubMed

    Graham, Steven; Jie, Hans Lee; Chan, Hui-Minn; McLaren, I P L; Wills, Andy J

    2011-04-01

    Demonstrations of retrospective revaluation suggest that remembered stimuli undergo a reduction in association with the unconditioned stimulus (US) present during learning. Conversely, demonstrations of mediated conditioning in flavor-conditioning experiments with rats suggest that remembered stimuli undergo an increase in association with the US present during learning. In a food allergy prediction task with 23 undergraduates, we demonstrated simultaneous backward conditioned inhibition and mediated conditioning effects. These results are compatible with the hypothesis that the direction of change (decrease or increase) in associative strength depends on whether the remembered stimulus was of a different category (conditioned stimulus/antecedent) or the same category (US/outcome) as the presented US. PMID:21319913

  2. Early Pavlovian conditioning impairs later Pavlovian conditioning.

    PubMed

    Lariviere, N A; Spear, N E

    1996-11-01

    Four experiments tested the effects in the rat of very early experience with stimuli to be used later for Pavlovian conditioning. Beginning on postnatal Day 12, prior to the development of substantial detection and effective perception of visual and auditory stimuli, rats were given five daily experiences with either lights or tones and a footshock known to be an effective unconditioned stimulus at these ages. Twenty-four hours after the last of these experiences, pairings of either the light or tone and the unconditioned stimulus were given with parameters established to yield a moderate degree of conditioning in untreated preweanlings (Experiment 1). Experiment 2 determined that early experience with paired or unpaired presentations of either the light or tone and the unconditioned stimulus resulted in a failure to condition to these same lights or tones on postnatal Day 17, although nontreated pups from the same litters conditioned quite effectively. Experiment 3 determined that this early conditioning experience with either paired or unpaired presentations of the lights or tones and the unconditioned stimulus yielded impaired conditioning on postnatal Day 17 in the alternative sensory modality as well, although again nontreated siblings conditioned quite effectively. Experiment 4 replicated the results of each of Experiments 2 and 3 and determined in addition that despite the impairment in conditioning that resulted from early paired or unpaired experience with the stimuli of conditioning, early experience with the individual stimuli of conditioning-with only the CS, the US, or the context-did not result in a similar impairment in conditioning. Although the results were unexpected, they may be understood in part in terms of intersensory competition during development, and there is precedent in the literature for similar interfering effects of early learning on later learning in a variety of species.

  3. Chinese Conditionals and the Theory of Conditionals.

    ERIC Educational Resources Information Center

    Chierchia, Gennaro

    2000-01-01

    Summarizes the main features of discourse representation theory, situation-based approaches, and dynamic semantics, and discusses the role the novelty condition plays in each of them, providing the main theoretical coordinates against which to try an assessment of the role of the Chinese conditional and a proposal put forth by Chang and Huang…

  4. REACH. Air Conditioning Units.

    ERIC Educational Resources Information Center

    Garrison, Joe; And Others

    As a part of the REACH (Refrigeration, Electro-Mechanical, Air-Conditioning, Heating) electromechanical cluster, this student manual contains individualized instructional units in the area of air conditioning. The instructional units focus on air conditioning fundamentals, window air conditioning, system and installation, troubleshooting and…

  5. Conditional knockout of retinal determination genes in differentiating cells in Drosophila.

    PubMed

    Jin, Meng; Eblimit, Aiden; Pulikkathara, Merlyn; Corr, Stuart; Chen, Rui; Mardon, Graeme

    2016-08-01

    Conditional gene knockout in postmitotic cells is a valuable technique which allows the study of gene function with spatiotemporal control. Surprisingly, in contrast to its long-term and extensive use in mouse studies, this technology is lacking in Drosophila. Here, we use a novel method for generating complete loss of eyes absent (eya) or sine oculis (so) function in postmitotic cells posterior to the morphogenetic furrow (MF). Specifically, genomic rescue constructs with flippase recognition target (FRT) sequences flanking essential exons are used to generate conditional null alleles. By removing gene function in differentiating cells, we show that eya and so are dispensable for larval photoreceptor differentiation, but are required for differentiation during pupal development. Both eya and so are necessary for photoreceptor survival and the apoptosis caused by loss of eya or so function is likely a secondary consequence of inappropriate differentiation. We also confirm their requirement for cone cell development and reveal a novel role in interommatidial bristle (IOB) formation. In addition, so is required for normal eye disc morphology. This is the first report of a knockout method to study eya and so function in postmitotic cells. This technology will open the door to a large array of new functional studies in virtually any tissue and at any stage of development or in adults. PMID:27257739

  6. A gaze-contingent display to study contrast sensitivity under natural viewing conditions

    NASA Astrophysics Data System (ADS)

    Dorr, Michael; Bex, Peter J.

    2011-03-01

    Contrast sensitivity has been extensively studied over the last decades and there are well-established models of early vision that were derived by presenting the visual system with synthetic stimuli such as sine-wave gratings near threshold contrasts. Natural scenes, however, contain a much wider distribution of orientations, spatial frequencies, and both luminance and contrast values. Furthermore, humans typically move their eyes two to three times per second under natural viewing conditions, but most laboratory experiments require subjects to maintain central fixation. We here describe a gaze-contingent display capable of performing real-time contrast modulations of video in retinal coordinates, thus allowing us to study contrast sensitivity when dynamically viewing dynamic scenes. Our system is based on a Laplacian pyramid for each frame that efficiently represents individual frequency bands. Each output pixel is then computed as a locally weighted sum of pyramid levels to introduce local contrast changes as a function of gaze. Our GPU implementation achieves real-time performance with more than 100 fps on high-resolution video (1920 by 1080 pixels) and a synthesis latency of only 1.5ms. Psychophysical data show that contrast sensitivity is greatly decreased in natural videos and under dynamic viewing conditions. Synthetic stimuli therefore only poorly characterize natural vision.

  7. RF impedance of intrinsic Josephson junction in flux-flow state with a periodic pinning potential and its optimum condition for RF radiation

    NASA Astrophysics Data System (ADS)

    Yamada, Y.; Nakajima, K.; Nakajima, K.

    2009-10-01

    We reported dynamics of Josephson vortices interacting with electromagnetic waves in strongly coupled long Josephson junctions stack, such as an intrinsic Josephson junction (IJJ), by numerical simulations based on coupled sine-Gordon equations considering a periodic pinning potential of sinusoidal form. The numerical simulation results for the influence of the electromagnetic waves on flux-flow properties show that the periodic pinning potential induces an in-phase motion of Josephson vortices over the junction stacks, which achieve high performances of IJJ flux-flow oscillator. In order to prove it from another viewpoint, we calculate RF impedance of long Josephson junction stacks in flux-flow state. A remarkable negative real part region of RF impedance appears at 1st harmonic step, it means that the long Josephson junction stacks in flux-flow state acts as an oscillator at the negative real part region. In this study, we evaluate the optimum condition for RF radiation with the periodic pinning potential.

  8. Lagrange interpolation and modified cubic B-spline differential quadrature methods for solving hyperbolic partial differential equations with Dirichlet and Neumann boundary conditions

    NASA Astrophysics Data System (ADS)

    Jiwari, Ram

    2015-08-01

    In this article, the author proposed two differential quadrature methods to find the approximate solution of one and two dimensional hyperbolic partial differential equations with Dirichlet and Neumann's boundary conditions. The methods are based on Lagrange interpolation and modified cubic B-splines respectively. The proposed methods reduced the hyperbolic problem into a system of second order ordinary differential equations in time variable. Then, the obtained system is changed into a system of first order ordinary differential equations and finally, SSP-RK3 scheme is used to solve the obtained system. The well known hyperbolic equations such as telegraph, Klein-Gordon, sine-Gordon, Dissipative non-linear wave, and Vander Pol type non-linear wave equations are solved to check the accuracy and efficiency of the proposed methods. The numerical results are shown in L∞ , RMS andL2 errors form.

  9. Baseball-specific conditioning.

    PubMed

    Rhea, Matthew R; Bunker, Derek

    2009-09-01

    Baseball demands speed, power, and quickness. To perform at a high level, and avoid injuries that are common among baseball players, an evaluation of current trends in strength and conditioning practices is helpful. Based on the demands of the sport and the injury risks, qualified strength and conditioning professionals can develop effective baseball-specific conditioning programs. This commentary briefly covers historical aspects of baseball conditioning, recent injury trends, current practices among elite baseball professionals, and provides suggestions for future improvements in training.

  10. Magnetohydrodynamic Characteristic Boundary Conditions

    NASA Astrophysics Data System (ADS)

    Schaffenberger, Werner; Stein, R.

    2009-05-01

    We implemented MHD characteristic boundary conditions for a non-ideal plasma in the "stagger-code" (Gudiksen and Nordlund, 2005, ApJ 618, 1020). The aim of these boundary conditions is to reduce reflection at the boundaries which is important for the simulation of wave propagation. We present some test simulations of propagating waves demonstrating the capability of these boundary conditions.

  11. Inflation of Conditional Predictions

    ERIC Educational Resources Information Center

    Koriat, Asher; Fiedler, Klaus; Bjork, Robert A.

    2006-01-01

    The authors report 7 experiments indicating that conditional predictions--the assessed probability that a certain outcome will occur given a certain condition--tend to be markedly inflated. The results suggest that this inflation derives in part from backward activation in which the target outcome highlights aspects of the condition that are…

  12. [Conditioning mechanisms and psychoneuroimmunology].

    PubMed

    Stockhorst, Ursula; Klosterhalfen, Sibylle

    2005-01-01

    This chapter deals with the role of conditioning principles in psychoneuroimmunology (PNI). We will first describe the paradigms of classical and instrumental conditioning and classify immune parameters that are subject to conditioning (chapter 1). So far, PNI research mainly uses classical (or Pavlovian) conditioning. We will summarize some of the paradigmatic studies, mainly animal studies (chapter 2) and also describe studies that support the clinical relevance of classical conditioning, i. e., in the pharmacological treatment of autoimmune diseases, transplantation and tumor chemotherapy (chapter 3). A study of our group on anticipatory immunomodulation in pediatric cancer patients is reported. Mechanisms mediating conditioned immunomodulation are summarized (chapter 4). We also describe studies that analyze the impact of instrumental conditioning contingencies on immune functioning (chapter 5). Finally, research perspectives are summarized (chapter 6).

  13. Context and Pavlovian conditioning.

    PubMed

    Landeira-Fernandez, J

    1996-02-01

    Procedurally, learning has to occur in a context. Several lines of evidence suggest that contextual stimuli actively affect learning and expression of the conditional response. The experimental context can become associated with the unconditional stimulus (US), especially when the US is presented in a context in the absence of a discrete conditional stimulus (CS). Moreover, context can modulate CS-US associations. Finally, it appears that context can become associated with the CS when it is presented before the CS-US training. The purpose of the present paper is to review some of the relevant literature that considers the context as an important feature of Pavlovian conditioning and to discuss some of the main learning theories that incorporate the context into their theoretical framework. The paper starts by mentioning historical positions that considered context an important variable in conditioning and then describes how the approach to contextual conditioning changed with the modern study of Pavlovian conditioning. Various forms of measurement of context conditioning are presented and the associative strength attached to context in several experimental paradigms is examined. The possible functions that context may acquire during conditioning are pointed out and related to major learning theories. Moreover, the effect of certain neurological manipulations on context conditioning is presented and these results are discussed in terms of possible functions that the context might acquire during Pavlovian conditioning. It is concluded that contextual stimuli acquire different functions during normal conditioning. A procedure in which animals are exposed to an aversive US immediately after they are placed in the experimental context is suggested as a useful control for the study of context conditioning.

  14. Common skin conditions.

    PubMed Central

    Ridley, M.; Safranek, M.

    1992-01-01

    Four common conditions: acne, psoriasis, eczema and urticaria are considered. Guidance is given on appropriate topical and systematic treatment for the different types and degrees of these conditions, with notes on management in general and criteria for referral to hospital outpatient departments. Where there are different types of the condition, with varying aetiology, for example in urticaria and eczema, management of the common types is outlined. PMID:1345156

  15. Nonbirefringence conditions for spacetime

    SciTech Connect

    Itin, Yakov

    2005-10-15

    Within the axiomatic premetric approach to classical electrodynamics, we derive under which covariant conditions the quartic Fresnel surface represents a unique light cone without birefringence in vacuum.

  16. Condition Assessment Information System

    2002-09-16

    CAIS2000 records, tracks and cost maintenance deficiencies associated with condition assessments of real property assets. Cost information is available for 39,000 items in the currenht RS Means, Facilities Construction Manual. These costs can, in turn, be rolled by by asset to produce the summary condition of an asset or site.

  17. Air-Conditioning Mechanic.

    ERIC Educational Resources Information Center

    Marine Corps Inst., Washington, DC.

    This student guide, one of a series of correspondence training courses designed to improve the job performance of members of the Marine Corps, deals with the skills needed by air conditioning mechanics. Addressed in the four chapters, or lessons, of the manual are the following topics: principles of air conditioning, refrigeration components as…

  18. CONDITIONAL DISTANCE CORRELATION

    PubMed Central

    Wang, Xueqin; Pan, Wenliang; Hu, Wenhao; Tian, Yuan; Zhang, Heping

    2015-01-01

    Statistical inference on conditional dependence is essential in many fields including genetic association studies and graphical models. The classic measures focus on linear conditional correlations, and are incapable of characterizing non-linear conditional relationship including non-monotonic relationship. To overcome this limitation, we introduces a nonparametric measure of conditional dependence for multivariate random variables with arbitrary dimensions. Our measure possesses the necessary and intuitive properties as a correlation index. Briefly, it is zero almost surely if and only if two multivariate random variables are conditionally independent given a third random variable. More importantly, the sample version of this measure can be expressed elegantly as the root of a V or U-process with random kernels and has desirable theoretical properties. Based on the sample version, we propose a test for conditional independence, which is proven to be more powerful than some recently developed tests through our numerical simulations. The advantage of our test is even greater when the relationship between the multivariate random variables given the third random variable cannot be expressed in a linear or monotonic function of one random variable versus the other. We also show that the sample measure is consistent and weakly convergent, and the test statistic is asymptotically normal. By applying our test in a real data analysis, we are able to identify two conditionally associated gene expressions, which otherwise cannot be revealed. Thus, our measure of conditional dependence is not only an ideal concept, but also has important practical utility. PMID:26877569

  19. Sheltered Living Conditions.

    ERIC Educational Resources Information Center

    Netherland's Central Society for Rehabilitation, The Hague.

    Resulting from a study conducted by the Advisory Housing Committee of the Dutch Society for Rehabilitation, the report describes housing conditions and possibilities for the physically handicapped in the Netherlands. Four categories of sheltered living conditions are described and analyzed: residential centers, supervised residential centers,…

  20. NATIONAL COASTAL CONDITION REPORT

    EPA Science Inventory

    The National Coastal Condition report compiles several available data sets from different agencies and areas of the country and summarizes them to present a broad baseline picture of the condition of coastal waters. Although data sets presented in this report do not cover all coa...

  1. Systematizing semishortening conditions

    NASA Astrophysics Data System (ADS)

    Ju, C.-Y.; Siegel, W.

    2014-12-01

    We rederive semishortening conditions for four-dimensional superconformal field theory with a different approach. These conditions have similar patterns that can be generalized to weaker constraints, including all those of Dolan and Osborn [Ann. Phys. (Amsterdam) 307, 41 (2003)]. In particular, for the case of N =4 super-Yang-Mills theory formulated in projective superspace, we find constraints for all Bogomol'nyi-Prasad-Sommerfield operators. We also give an example how constraints can be found from known ones. These constraints are a subset of our maximal set of semishortening conditions.

  2. Etiquette of Verbal Conditioning

    ERIC Educational Resources Information Center

    Denner, Bruce

    1970-01-01

    Explores role of ambiguity in producing verbal conditioning by using two E types and two S types. Six college students were assigned to "crafty Es. Results revealed that certain types of ambiguity increase verbal compliance. (Author)

  3. Operant Conditioning and Education.

    ERIC Educational Resources Information Center

    de Noronha, Mario

    A case study of a learning disabled 8-year-old with behavior disturbancs is presented to highlight the use of operant conditioning in cutting down educational costs and easing the teacher's class management problems. (CL)

  4. Skin Conditions during Pregnancy

    MedlinePlus

    ... during pregnancy? • What is pruritic urticarial papules and plaques of pregnancy (PUPPP)? • What is prurigo of pregnancy? • ... itchy skin. What is pruritic urticarial papules and plaques of pregnancy (PUPPP)? In this condition, small, red ...

  5. Common Childhood Orthopedic Conditions

    MedlinePlus

    ... Ones & When? Smart School Lunches Emmy-Nominated Video "Cerebral Palsy: Shannon's Story" 5 Things to Know About Zika & ... might be linked to other conditions, such as cerebral palsy, muscle weakness disorders, autism, or other nervous system ...

  6. Aerobic Conditioning Class.

    ERIC Educational Resources Information Center

    Johnson, Neil R.

    1980-01-01

    An aerobic exercise class that focuses on the conditioning of the cardiovascular and muscular systems is presented. Students complete data cards on heart rate, pulse, and exercises to be completed during the forty minute course. (CJ)

  7. Lung Diseases and Conditions

    MedlinePlus

    ... Share this page from the NHLBI on Twitter. Lung Diseases and Conditions Breathing is a complex process. ... your bronchial tubes ( bronchitis ) or deep in your lungs ( pneumonia ). These infections cause a buildup of mucus ...

  8. Pavement condition data analysis

    SciTech Connect

    Zaniewski, J.P.; Hudson, S.W.; Hudson, W.R.

    1987-07-01

    This paper describes a computer methodology for analyzing pavement condition data to define inputs for pavement management systems. This system of programs was developed during a Federal Highway Administration research project. In the project, eight state highway departments were studied to determine the types of pavement condition data collected, procedures used for collecting data, the inputs to the states' pavement management systems, and computer programs used by the states to analyze raw pavement condition data. Several of the programs were assembled into the Method for Analyzing Pavement Condition, MAPCON, during a project performed at Pennsylvania State University. These and other existing or new programs (a total of 18) were identified, tested, modified, and incorporated onto a MS/DOS microcomputer system. MAPCON guides the user through selection of analysis method, raw data entry, and data analysis.

  9. Climatic Conditions in Classrooms.

    ERIC Educational Resources Information Center

    Kevan, Simon M.; Howes, John D.

    1980-01-01

    Presents an overview of research on the ways in which classroom thermal environment, lighting conditions, ion state, and electromagnetic and air pollution affect learning and the performance of students and teachers. (SJL)

  10. Conditional data watchpoint management

    DOEpatents

    Burdick, Dean Joseph; Vaidyanathan, Basu

    2010-08-24

    A method, system and computer program product for managing a conditional data watchpoint in a set of instructions being traced is shown in accordance with illustrative embodiments. In one particular embodiment, the method comprises initializing a conditional data watchpoint and determining the watchpoint has been encountered. Upon that determination, examining a current instruction context associated with the encountered watchpoint prior to completion of the current instruction execution, further determining a first action responsive to a positive context examination; otherwise, determining a second action.

  11. Power supply conditioning circuit

    NASA Technical Reports Server (NTRS)

    Primas, Lori E. (Inventor); Loveland, Rohan C. (Inventor)

    1988-01-01

    A conditioning circuit is provided with a constant current diode in series with a zener diode, the former having a high dynamic impedance and the latter a low dynamic impedance. The constant current diode can receive an input voltage with PARD. In conjunction with the zener diode fixed to a ground, a voltage divider is provided which can give an output voltage whose PARD was significantly reduced. The conditioning circuit is effective down to dc.

  12. Chemical conditioning of sludge.

    PubMed

    Novak, J T; Park, C

    2004-01-01

    With all the advances made in understanding the structure and composition of sewage sludges, chemical conditioning remains a trial and error process, both with regard to the type and dose of conditioner needed. Recent studies at Virginia Tech have found that biological floc consists of two types of biopolymer, material associated with iron and aluminium and material associated with calcium and magnesium. These materials behave differently when sludges undergo digestion. This results in very different material being released into solution during digestion and very different conditioning requirements. This study shows that the primary materials released during anaerobic digestion are proteins and coagulation of the colloidal protein fraction in solution is the primary mechanism for conditioning. For aerobically digested sludges, both proteins and polysaccharides make up the colloid fraction, which interferes with dewatering. This research also shows that the effectiveness of the digestion process as characterized by volatile solids destruction is directly related to the chemical dose required for conditioning. That is, as the solids destruction increases, the conditioning chemical requirement also increases. Well digested sludges dewater more poorly and require more conditioning chemical than those with less volatile solids destruction. PMID:15259940

  13. Causal conditionals and counterfactuals

    PubMed Central

    Frosch, Caren A.; Byrne, Ruth M.J.

    2012-01-01

    Causal counterfactuals e.g., ‘if the ignition key had been turned then the car would have started’ and causal conditionals e.g., ‘if the ignition key was turned then the car started’ are understood by thinking about multiple possibilities of different sorts, as shown in six experiments using converging evidence from three different types of measures. Experiments 1a and 1b showed that conditionals that comprise enabling causes, e.g., ‘if the ignition key was turned then the car started’ primed people to read quickly conjunctions referring to the possibility of the enabler occurring without the outcome, e.g., ‘the ignition key was turned and the car did not start’. Experiments 2a and 2b showed that people paraphrased causal conditionals by using causal or temporal connectives (because, when), whereas they paraphrased causal counterfactuals by using subjunctive constructions (had…would have). Experiments 3a and 3b showed that people made different inferences from counterfactuals presented with enabling conditions compared to none. The implications of the results for alternative theories of conditionals are discussed. PMID:22858874

  14. Choice and conditioned reinforcement.

    PubMed

    Fantino, E; Freed, D; Preston, R A; Williams, W A

    1991-03-01

    A potential weakness of one formulation of delay-reduction theory is its failure to include a term for rate of conditioned reinforcement, that is, the rate at which the terminal-link stimuli occur in concurrent-chains schedules. The present studies assessed whether or not rate of conditioned reinforcement has an independent effect upon choice. Pigeons responded on either modified concurrent-chains schedules or on comparable concurrent-tandem schedules. The initial link was shortened on only one of two concurrent-chains schedules and on only one of two corresponding concurrent-tandem schedules. This manipulation increased rate of conditioned reinforcement sharply in the chain but not in the tandem schedule. According to a formulation of delay-reduction theory, when the outcomes chosen (the terminal links) are equal, as in Experiment 1, choice should depend only on rate of primary reinforcement; thus, choice should be equivalent for the tandem and chain schedules despite a large difference in rate of conditioned reinforcement. When the outcomes chosen are unequal, however, as in Experiment 2, choice should depend upon both rate of primary reinforcement and relative signaled delay reduction; thus, larger preferences should occur in the chain than in the tandem schedules. These predictions were confirmed, suggesting that increasing the rate of conditioned reinforcement on concurrent-chains schedules may have no independent effect on choice.

  15. Conditional E-Cash

    NASA Astrophysics Data System (ADS)

    Shi, Larry; Carbunar, Bogdan; Sion, Radu

    We introduce a novel conditional e-cash protocol allowing future anonymous cashing of bank-issued e-money only upon the satisfaction of an agreed-upon public condition. Payers are able to remunerate payees for services that depend on future, yet to be determined outcomes of events. Once payment complete, any double-spending attempt by the payer will reveal its identity; no double-spending by the payee is possible. Payers can not be linked to payees or to ongoing or past transactions. The flow of cash within the system is thus both correct and anonymous. We discuss several applications of conditional e-cash including online trading of financial securities, prediction markets, and betting systems.

  16. Universal signal conditioning amplifier

    NASA Technical Reports Server (NTRS)

    Larson, William E.; Hallberg, Carl; Medelius, Pedro J.

    1994-01-01

    Engineers at NASA's Kennedy Space Center have designed a signal conditioning amplifier which automatically matches itself to almost any kind of transducer. The product, called Universal Signal Conditioning Amplifier (USCA), uses state-of-the-art technologies to deliver high accuracy measurements. USCA's features which can be either programmable or automated include: voltage, current, or pulsed excitation, unlimited resolution gain, digital filtering and both analog and digital output. USCA will be used at Kennedy Space Center's launch pads for environmental measurements such as vibrations, strains, temperatures and overpressures. USCA is presently being commercialized through a co-funded agreement between NASA, the State of Florida, and Loral Test and Information Systems, Inc.

  17. Mineralogy under extreme conditions

    SciTech Connect

    Shu, Jinfu

    2012-02-07

    We have performed measurements of minerals based on the synchrotron source for single crystal and powder X-ray diffraction, inelastic scattering, spectroscopy and radiography by using diamond anvil cells. We investigated the properties of iron (Fe), iron-magnesium oxides (Fe, Mg)O, silica(SiO{sub 2}), iron-magnesium silicates (Fe, Mg)SiO{sub 3} under simulated high pressure-high temperature extreme conditions of the Earth's crust, upper mantle, low mantle, core-mantle boundary, outer core, and inner core. The results provide a new window on the investigation of the mineral properties at Earth's conditions.

  18. Operant Conditioning - Token Economy.

    ERIC Educational Resources Information Center

    Montgomery, Jacqueline; McBurney, Raymond D.

    Described is an Operant Conditioning-Token Economy Program, teaching patients to be responsible for their own behavior, to make choices, and to be motivated to change. The program was instigated with mentally ill patients in a state hospital and was later used with institutionalized mentally handicapped groups. After two years, only four of the…

  19. Teachers and Operant Conditioning.

    ERIC Educational Resources Information Center

    Frey, Sherman

    A survey was conducted of 406 elementary, middle, and secondary school teachers to determine their understanding, acceptance, and use of the principle of operant conditioning. The treatment of data was by percent and chi square analysis primarily according to sex, experience, degree, and position. Subjects reported that a) they believed that the…

  20. Workplace Conditions. Brief

    ERIC Educational Resources Information Center

    National Education Association Research Department, 2006

    2006-01-01

    This brief describes workplace conditions in "learning centered" schools, where practices are consistent with recent research knowledge about learning and its contexts. Its purpose is to support fundamental, long-term change by offering a vision of best practice for educators to consider, discuss, and adapt to their circumstances. It summarizes…

  1. Expectation and conditioning

    NASA Astrophysics Data System (ADS)

    Coster, Adelle C. F.; Alstrøm, Preben

    2001-02-01

    We present a dynamical model that embodies both classical and instrumental conditioning paradigms in the same framework. The model is based on the formation of expectations of stimuli and of rewards. The expectations of stimuli are formed in a recurrent process called expectation learning in which one activity pattern evokes another. The expectation of rewards or punishments (motivation) is modelled using reinforcement learning.

  2. Impacts of sociopolitical conditions

    NASA Technical Reports Server (NTRS)

    Finney, Ben R.

    1992-01-01

    Space development scenarios and the choice of technologies to carry them out depend upon the future social, economic, and political factors. A brief discussion concerning the impact of sociopolitical conditions on space exploration is presented. Some of the topics mentioned include: space weapons/warfare, international cooperation, NASA's Search for Extraterrestrial Intelligence (SETI) Program, and superpower rivelry.

  3. Effective Conditions for Learning

    ERIC Educational Resources Information Center

    Ball, Barbara; Ball, Derek

    2007-01-01

    In this article, the authors respond to four 2006 "Mathematics Teaching" articles by Paul Andrews and Judy Sayers comparing conditions for learning mathematics in England and in four other European countries. They reflect on what might be done with English education, and with English mathematics education in particular. They challenge Andrews' and…

  4. Preventing Secondary Conditions.

    ERIC Educational Resources Information Center

    Pope, Andrew M.

    1992-01-01

    This paper presents the Institute of Medicine model of the dynamic nature of the disabling process of both primary disabilities and secondary conditions, and the interaction of that process with risk factors and quality of life. The components of a comprehensive disability prevention program are discussed. (Author/JDD)

  5. Power supply conditioning circuit

    NASA Technical Reports Server (NTRS)

    Primas, L. E.; Loveland, R.

    1987-01-01

    A power supply conditioning circuit that can reduce Periodic and Random Deviations (PARD) on the output voltages of dc power supplies to -150 dBV from dc to several KHz with no measurable periodic deviations is described. The PARD for a typical commercial low noise power supply is -74 dBV for frequencies above 20 Hz and is often much worse at frequencies below 20 Hz. The power supply conditioning circuit described here relies on the large differences in the dynamic impedances of a constant current diode and a zener diode to establish a dc voltage with low PARD. Power supplies with low PARD are especially important in circuitry involving ultrastable frequencies for the Deep Space Network.

  6. Quantum conditional operations

    NASA Astrophysics Data System (ADS)

    Bisio, Alessandro; Dall'Arno, Michele; Perinotti, Paolo

    2016-08-01

    An essential element of classical computation is the "if-then" construct, that accepts a control bit and an arbitrary gate, and provides conditional execution of the gate depending on the value of the controlling bit. On the other hand, quantum theory prevents the existence of an analogous universal construct accepting a control qubit and an arbitrary quantum gate as its input. Nevertheless, there are controllable sets of quantum gates for which such a construct exists. Here we provide a necessary and sufficient condition for a set of unitary transformations to be controllable, and we give a complete characterization of controllable sets in the two-dimensional case. This result reveals an interesting connection between the problem of controllability and the problem of extracting information from an unknown quantum gate while using it.

  7. Conditional statistical model building

    NASA Astrophysics Data System (ADS)

    Hansen, Mads Fogtmann; Hansen, Michael Sass; Larsen, Rasmus

    2008-03-01

    We present a new statistical deformation model suited for parameterized grids with different resolutions. Our method models the covariances between multiple grid levels explicitly, and allows for very efficient fitting of the model to data on multiple scales. The model is validated on a data set consisting of 62 annotated MR images of Corpus Callosum. One fifth of the data set was used as a training set, which was non-rigidly registered to each other without a shape prior. From the non-rigidly registered training set a shape prior was constructed by performing principal component analysis on each grid level and using the results to construct a conditional shape model, conditioning the finer parameters with the coarser grid levels. The remaining shapes were registered with the constructed shape prior. The dice measures for the registration without prior and the registration with a prior were 0.875 +/- 0.042 and 0.8615 +/- 0.051, respectively.

  8. High voltage pulse conditioning

    DOEpatents

    Springfield, Ray M.; Wheat, Jr., Robert M.

    1990-01-01

    Apparatus for conditioning high voltage pulses from particle accelerators in order to shorten the rise times of the pulses. Flashover switches in the cathode stalk of the transmission line hold off conduction for a determinable period of time, reflecting the early portion of the pulses. Diodes upstream of the switches divert energy into the magnetic and electrostatic storage of the capacitance and inductance inherent to the transmission line until the switches close.

  9. Fuel gas conditioning process

    DOEpatents

    Lokhandwala, Kaaeid A.

    2000-01-01

    A process for conditioning natural gas containing C.sub.3+ hydrocarbons and/or acid gas, so that it can be used as combustion fuel to run gas-powered equipment, including compressors, in the gas field or the gas processing plant. Compared with prior art processes, the invention creates lesser quantities of low-pressure gas per unit volume of fuel gas produced. Optionally, the process can also produce an NGL product.

  10. Mining Conditional Phosphorylation Motifs.

    PubMed

    Liu, Xiaoqing; Wu, Jun; Gong, Haipeng; Deng, Shengchun; He, Zengyou

    2014-01-01

    Phosphorylation motifs represent position-specific amino acid patterns around the phosphorylation sites in the set of phosphopeptides. Several algorithms have been proposed to uncover phosphorylation motifs, whereas the problem of efficiently discovering a set of significant motifs with sufficiently high coverage and non-redundancy still remains unsolved. Here we present a novel notion called conditional phosphorylation motifs. Through this new concept, the motifs whose over-expressiveness mainly benefits from its constituting parts can be filtered out effectively. To discover conditional phosphorylation motifs, we propose an algorithm called C-Motif for a non-redundant identification of significant phosphorylation motifs. C-Motif is implemented under the Apriori framework, and it tests the statistical significance together with the frequency of candidate motifs in a single stage. Experiments demonstrate that C-Motif outperforms some current algorithms such as MMFPh and Motif-All in terms of coverage and non-redundancy of the results and efficiency of the execution. The source code of C-Motif is available at: https://sourceforge. net/projects/cmotif/. PMID:26356863

  11. Childhood Eye Diseases and Conditions

    MedlinePlus

    ... and Conditions Nov. 01, 2013 The importance of vision screening There are many eye conditions and diseases ... child’s vision. Focus and alignment disorders that affect vision If any of the following conditions is suspected, ...

  12. How Are Genetic Conditions Diagnosed?

    MedlinePlus

    ... Consultation How are genetic conditions diagnosed? How are genetic conditions diagnosed? A doctor may suspect a diagnosis ... and advocacy resources. For more information about diagnosing genetic conditions: Genetics Home Reference provides information about genetic ...

  13. Remote Ischemic Conditioning

    PubMed Central

    Heusch, Gerd; Bøtker, Hans Erik; Przyklenk, Karin; Redington, Andrew; Yellon, Derek

    2014-01-01

    In remote ischemic conditioning (RIC) brief, reversible episodes of ischemia with reperfusion in one vascular bed, tissue or organ confer a global protective phenotype and render remote tissues and organs resistant to ischemia/reperfusion injury. The peripheral stimulus can be chemical, mechanical or electrical and involves activation of peripheral sensory nerves. The signal transfer to the heart or other organs is through neuronal and humoral communications. Protection can be transferred, even across species, with plasma-derived dialysate and involves nitric oxide, stromal derived factor-1α, microRNA-144, but also other, not yet identified factors. Intracardiac signal transduction involves: adenosine, bradykinin, cytokines, and chemokines, which activate specific receptors; intracellular kinases; and mitochondrial function. RIC by repeated brief inflation/deflation of a blood pressure cuff protects against endothelial dysfunction and myocardial injury in percutaneous coronary interventions, coronary artery bypass grafting and reperfused acute myocardial infarction. RIC is safe and effective, noninvasive, easily feasible and inexpensive. PMID:25593060

  14. Explaining Verification Conditions

    NASA Technical Reports Server (NTRS)

    Deney, Ewen; Fischer, Bernd

    2006-01-01

    The Hoare approach to program verification relies on the construction and discharge of verification conditions (VCs) but offers no support to trace, analyze, and understand the VCs themselves. We describe a systematic extension of the Hoare rules by labels so that the calculus itself can be used to build up explanations of the VCs. The labels are maintained through the different processing steps and rendered as natural language explanations. The explanations can easily be customized and can capture different aspects of the VCs; here, we focus on their structure and purpose. The approach is fully declarative and the generated explanations are based only on an analysis of the labels rather than directly on the logical meaning of the underlying VCs or their proofs. Keywords: program verification, Hoare calculus, traceability.

  15. Conditional sterility in plants

    DOEpatents

    Meagher, Richard B.; McKinney, Elizabeth; Kim, Tehryung

    2010-02-23

    The present disclosure provides methods, recombinant DNA molecules, recombinant host cells containing the DNA molecules, and transgenic plant cells, plant tissue and plants which contain and express at least one antisense or interference RNA specific for a thiamine biosynthetic coding sequence or a thiamine binding protein or a thiamine-degrading protein, wherein the RNA or thiamine binding protein is expressed under the regulatory control of a transcription regulatory sequence which directs expression in male and/or female reproductive tissue. These transgenic plants are conditionally sterile; i.e., they are fertile only in the presence of exogenous thiamine. Such plants are especially appropriate for use in the seed industry or in the environment, for example, for use in revegetation of contaminated soils or phytoremediation, especially when those transgenic plants also contain and express one or more chimeric genes which confer resistance to contaminants.

  16. Signal conditioning system

    NASA Technical Reports Server (NTRS)

    Zahzah, Mohamad (Inventor); Korkosz, Gregory J. (Inventor); Bohr, Gerald (Inventor)

    2000-01-01

    A current-driven signal conditioning system comprising a first terminal, a second terminal, a strain gauge, and an instrumentation amplifier is disclosed. The strain gauge is adapted to measure a deformation of a structure and to generate a resistance which corresponds to the measured deformation. The instrumentation amplifier is adapted to be connected between the first terminal and the second terminal. The instrumentation amplifier is further adapted to be connected to the strain gauge and to place an output current on the second terminal. The output current is proportional to the resistance generated by the strain gauge. An output resister is coupled between the strain gauge and the second terminal, and a capacitor is coupled between the resister and the first terminal. A zenor diode is coupled between the first terminal and the strain gauge, and a diode is also coupled between the first terminal and the strain gauge.

  17. Initial Cladding Condition

    SciTech Connect

    E. Siegmann

    2000-08-22

    The purpose of this analysis is to describe the condition of commercial Zircaloy clad fuel as it is received at the Yucca Mountain Project (YMP) site. Most commercial nuclear fuel is encased in Zircaloy cladding. This analysis is developed to describe cladding degradation from the expected failure modes. This includes reactor operation impacts including incipient failures, potential degradation after reactor operation during spent fuel storage in pool and dry storage and impacts due to transportation. Degradation modes include cladding creep, and delayed hydride cracking during dry storage and transportation. Mechanical stresses from fuel handling and transportation vibrations are also included. This Analysis and Model Report (AMR) does not address any potential damage to assemblies that might occur at the YMP surface facilities. Ranges and uncertainties have been defined. This analysis will be the initial boundary condition for the analysis of cladding degradation inside the repository. In accordance with AP-2.13Q, ''Technical Product Development Planning'', a work plan (CRWMS M&O 2000c) was developed, issued, and utilized in the preparation of this document. There are constraints, caveats and limitations to this analysis. This cladding degradation analysis is based on commercial Pressurized Water Reactor (PWR) fuel with Zircaloy cladding but is applicable to Boiling Water Reactor (BWR) fuel. Reactor operating experience for both PWRs and BWRs is used to establish fuel reliability from reactor operation. It is limited to fuel exposed to normal operation and anticipated operational occurrences (i.e. events which are anticipated to occur within a reactor lifetime), and not to fuel that has been exposed to severe accidents. Fuel burnup projections have been limited to the current commercial reactor licensing environment with restrictions on fuel enrichment, oxide coating thickness and rod plenum pressures. The information provided in this analysis will be used in

  18. Magnetic conditioning in superfluid

    SciTech Connect

    Caspi, S.

    1988-08-01

    Improvements in superconducting magnet technology have reduced to a handful the number of training quenches typical of dipole magnets. The number of training quenches in long (17 m) and short (1--2 m) SSC magnets are now about the same (operating at 6.6 tesla and 4.4 K). Yet the steps necessary to totally eliminate training are in the future RandD plans for magnet construction and conductor motion prevention. The accepted hypothesis is that Lorentz forces and poor mechanical properties of superconducting cables are the cause of conductor motion. Conductor motion reduces the stored energy in the cable by converting it into heat. The small amount of heat generated (millijoules) during motion is usually enough to quench the magnet when it is close to short sample. During training, the magnet performance normally improves with the number of quenches. It is not the quench itself that improves magnet performance but rather the fact that once conductor motion has occurred it will probably not repeat itself unless subjected to higher forces. Conditioning is a process that enables the magnet to reduce its stored energy without causing a premature quench. During the conditioning process the magnet is further cooled from its operating temperature of 4.4 K to 1.8 K by converting He I into He II. As a result the magnet is placed in a state where it has excess stability as well as excellent heat transfer capabilities. Although this does not eliminate motion, if the magnet is now cycled to /approximately/10% above its operating field at 4.4 K (which is above short sample) the excess stability should be enough to prevent quenching and reduce the probability of conductor motion and training once the magnet has been warmed back up to its operating temperature of 4.4 K. 3 refs., 5 figs.

  19. Verbal Conditioning and Therapeutic Change

    ERIC Educational Resources Information Center

    Lapuc, Paul S.; Harmatz, Morton G.

    1970-01-01

    Investigates the generalization of verbal conditioning effects to postconditioning personality and behavioral measures. Results demonstrated conditioning and generalization to some of the personality measures. (Author)

  20. Acoustic source characteristics, across-formant integration, and speech intelligibility under competitive conditions.

    PubMed

    Roberts, Brian; Summers, Robert J; Bailey, Peter J

    2015-06-01

    An important aspect of speech perception is the ability to group or select formants using cues in the acoustic source characteristics--for example, fundamental frequency (F0) differences between formants promote their segregation. This study explored the role of more radical differences in source characteristics. Three-formant (F1+F2+F3) synthetic speech analogues were derived from natural sentences. In Experiment 1, F1+F3 were generated by passing a harmonic glottal source (F0 = 140 Hz) through second-order resonators (H1+H3); in Experiment 2, F1+F3 were tonal (sine-wave) analogues (T1+T3). F2 could take either form (H2 or T2). In some conditions, the target formants were presented alone, either monaurally or dichotically (left ear = F1+F3; right ear = F2). In others, they were accompanied by a competitor for F2 (F1+F2C+F3; F2), which listeners must reject to optimize recognition. Competitors (H2C or T2C) were created using the time-reversed frequency and amplitude contours of F2. Dichotic presentation of F2 and F2C ensured that the impact of the competitor arose primarily through informational masking. In the absence of F2C, the effect of a source mismatch between F1+F3 and F2 was relatively modest. When F2C was present, intelligibility was lowest when F2 was tonal and F2C was harmonic, irrespective of which type matched F1+F3. This finding suggests that source type and context, rather than similarity, govern the phonetic contribution of a formant. It is proposed that wideband harmonic analogues are more effective informational maskers than narrowband tonal analogues, and so become dominant in across-frequency integration of phonetic information when placed in competition. PMID:25751040

  1. Flue gas conditioning today

    SciTech Connect

    Southam, B.J.; Coe, E.L. Jr.

    1995-12-01

    Many relatively small electrostatic precipitators (ESP`s) exist which collect fly ash at remarkably high efficiencies and have been tested consistently at correspondingly high migration velocities. But the majority of the world`s coal supplies produce ashes which are collected at much lower migration velocities for a given efficiency and therefore require correspondingly large specific collection areas to achieve acceptable results. Early trials of flue gas conditioning (FGC) showed benefits in maximizing ESP performance and minimizing expense which justified continued experimentation. Trials of several dozen ways of doing it wrong eventually developed a set of reliable rules for doing it right. One result is that the use of sulfur trioxide (SO{sub 3}) for adjustment of the resistivity of fly ash from low sulfur coal has been widely applied and has become an automatically accepted part of the option of burning low sulfur coal for compliance with the Clean Air Act of l990 in the U.S.A. Currently, over 100,000 MW of generating capacity is using FGC, and it is estimated that approximately 45,800 MW will utilize coal-switching with FGC for Clean Air Act emission compliance. Guarantees that this equipment will be available to operate at least 98 percent of the time it is called upon are routinely fulfilled.

  2. Universal Signal Conditioning Amplifier

    NASA Technical Reports Server (NTRS)

    Kinney, Frank

    1997-01-01

    The Technological Research and Development Authority (TRDA) and NASA-KSC entered into a cooperative agreement in March of 1994 to achieve the utilization and commercialization of a technology development for benefiting both the Space Program and U.S. industry on a "dual-use basis". The technology involved in this transfer is a new, unique Universal Conditioning Amplifier (USCA) used in connection with various types of transducers. The project was initiated in partnership with I-Net Corporation, Lockheed Martin Telemetry & Instrumentation (formerly Loral Test and Information Systems) and Brevard Community College. The project consists of designing, miniaturizing, manufacturing, and testing an existing prototype of USCA that was developed for NASA-KSC by the I-Net Corporation. The USCA is a rugged and field-installable self (or remotely)- programmable amplifier that works in combination with a tag random access memory (RAM) attached to various types of transducers. This summary report comprises performance evaluations, TRDA partnership tasks, a project summary, project milestones and results.

  3. Thermal condition of Surtsey

    NASA Astrophysics Data System (ADS)

    Stefansson, V.; Axelsson, G.; Sigurdsson, O.; Gudmundsson, G.; Steingrimsson, B.

    1985-12-01

    The island Surtsey was created by a submarine volcanic eruption which started on the 14th of November 1963, 21 km southwest of the Westman Islands. Volcanic activity continued in this area for nearly 4 years. During the summer of 1979 a 181 m deep continuously cored borehole was drilled on the Surtsey island. Several temperature profiles have been measured in the hole since 1979. The results of these temperature measurements are used as the basis for a discussion of the thermal condition of Surtsey. The hypothesis that intrusions rather than pillow lavas are responsible for the excess heat content of Surtsey is favored. It is found that the 13 m thick discontinuous dike complex, observed in the drill core, is sufficient to explain the excess heat content in the vicinity of the borehole and the shape of the temperature profiles recorded. It is demonstrated that the heat transfer in Surtsey has been dominated by hydrothermal convection and that the system is vapor dominated above sea level. It is estimated that the permeability of a 40 m thick section of altered tuff below sea level is 4.1 × 10 -13 m 2, while the permeability of the unaltered tuff above sea level is estimated as 1.2 × 10 -10 m 2.

  4. Universal signal conditioning amplifier

    NASA Technical Reports Server (NTRS)

    Medelius, Pedro J.; Hallberg, Carl; Cecil, Jim

    1994-01-01

    A state-of-the-art instrumentation amplifier capable of being used with most types of transducers has been developed at the Kennedy Space Center. This Universal Signal Conditioning Amplifier (USCA) can eliminate costly measurement setup item and troubleshooting, improve system reliability and provide more accurate data than conventional amplifiers. The USCA can configure itself for maximum resolution and accuracy based on information read from a RAM chip attached to each transducer. Excitation voltages or current are also automatically configured. The amplifier uses both analog and digital state-of-the-art technology with analog-to-digital conversion performed in the early stages in order to minimize errors introduced by offset and gain drifts in the analog components. A dynamic temperature compensation scheme has been designed to achieve and maintain 12-bit accuracy of the amplifier from 0 to 70 C. The digital signal processing section allows the implementation of digital filters up to 511th order. The amplifier can also perform real-time linearizations up to fourth order while processing data at a rate of 23.438 kS/s. Both digital and analog outputs are available from the amplifier.

  5. The Probabilities of Conditionals Revisited

    ERIC Educational Resources Information Center

    Douven, Igor; Verbrugge, Sara

    2013-01-01

    According to what is now commonly referred to as "the Equation" in the literature on indicative conditionals, the probability of any indicative conditional equals the probability of its consequent of the conditional given the antecedent of the conditional. Philosophers widely agree in their assessment that the triviality arguments of…

  6. The Probability of Causal Conditionals

    ERIC Educational Resources Information Center

    Over, David E.; Hadjichristidis, Constantinos; Evans, Jonathan St. B. T.; Handley, Simon J.; Sloman, Steven A.

    2007-01-01

    Conditionals in natural language are central to reasoning and decision making. A theoretical proposal called the Ramsey test implies the conditional probability hypothesis: that the subjective probability of a natural language conditional, P(if p then q), is the conditional subjective probability, P(q [such that] p). We report three experiments on…

  7. Assessing the planet's condition.

    PubMed

    Brown, L R

    1990-01-01

    The destruction of the environment has accelerated since the Earth Day of 1970, the world's population has increased by another 1.6 billion, and over 500 million acres of forest have been lost. Carbon dioxide levels, greenhouse gases, and chlorofluorocarbons have increased in the atmosphere with evidence that global warming has started. The ozone hole has appeared, acid rain has destroyed forests, air pollution in major northern hemisphere cities has worsened, and species are disappearing, while toxic chemicals have been dumped indiscriminately. World grain production has fallen while population has increased. In Europe 14 countries have stabilized their population, and Japan, France, and Finland are on the way to zero growth. Reduction of high fertility in 1/2 could halt the deterioration of living conditions. Japan and China achieved this within a decade. Energy efficiency has to be attained; US cars still consume too much gas. Solar energy with photovoltaic cells to provide power, fuel alcohol from plants, and solar thermal power plants have potential. Semiarid regions, such as northern Africa, could become major producers of solar energy. Various measures are mandatory to cut down on waste: to recycle paper bags, to use standardized glasses for beverages, and to utilize scrap metal in electric arc steel furnaces. Reforestation is also on the agenda, as major deforestation has occurred in the Brazilian Amazon region, in India, and in Europe because of acid rain. Australia's national plan envisions planting 1 billion trees, and the US project is of similar magnitude during the 1990s. Only the US has succeeded in erosion control and topsoil stabilization when it converted erodible cropland into grassland or woodland during 1986-90.

  8. Assessing the planet's condition.

    PubMed

    Brown, L R

    1990-01-01

    The destruction of the environment has accelerated since the Earth Day of 1970, the world's population has increased by another 1.6 billion, and over 500 million acres of forest have been lost. Carbon dioxide levels, greenhouse gases, and chlorofluorocarbons have increased in the atmosphere with evidence that global warming has started. The ozone hole has appeared, acid rain has destroyed forests, air pollution in major northern hemisphere cities has worsened, and species are disappearing, while toxic chemicals have been dumped indiscriminately. World grain production has fallen while population has increased. In Europe 14 countries have stabilized their population, and Japan, France, and Finland are on the way to zero growth. Reduction of high fertility in 1/2 could halt the deterioration of living conditions. Japan and China achieved this within a decade. Energy efficiency has to be attained; US cars still consume too much gas. Solar energy with photovoltaic cells to provide power, fuel alcohol from plants, and solar thermal power plants have potential. Semiarid regions, such as northern Africa, could become major producers of solar energy. Various measures are mandatory to cut down on waste: to recycle paper bags, to use standardized glasses for beverages, and to utilize scrap metal in electric arc steel furnaces. Reforestation is also on the agenda, as major deforestation has occurred in the Brazilian Amazon region, in India, and in Europe because of acid rain. Australia's national plan envisions planting 1 billion trees, and the US project is of similar magnitude during the 1990s. Only the US has succeeded in erosion control and topsoil stabilization when it converted erodible cropland into grassland or woodland during 1986-90. PMID:12285798

  9. Conditioned stimulus determinants of conditioned response form in Pavlovian fear conditioning.

    PubMed

    Kim, S D; Rivers, S; Bevins, R A; Ayres, J J

    1996-01-01

    Four experiments using barpress conditioned suppression in rats found that tone evoked more freezing (immobility) than did light. Still, tone and light appeared to have similar conditioned value as assessed by suppression in Experiments 1, 2, and 3, and by blocking, second-order conditioning, and overconditioning assays in Experiments 1, 2, and 3, respectively. Experiment 4 arranged for tone to evoke less suppression than light but more freezing. Results suggest that in fear conditioning, the nature of the conditioned stimulus affects the form of conditioned responding (strong vs. weak freezing). This conclusion extends one drawn by P. C. Holland (1977) on the basis of his work in appetitive conditioning.

  10. Spaghetti Sine Curves: Virtual Environments for Reasoning and Sense Making

    ERIC Educational Resources Information Center

    Özgün-Koca, S. Asli; Edwards, Michael Todd; Meagher, Michael

    2013-01-01

    In a recent collaboration with an area high school teacher, the authors were asked to develop an introductory sinusoidal curves lesson for a group of second-year algebra students. Because the topic was abstract and unfamiliar to these tenth graders, they looked for hands-on lessons to support their learning. One lesson that they found, which they…

  11. Sine ars scientia nihil est: Leonardo da Vinci and beyond.

    PubMed

    Kickhöfel, Eduardo H P

    2009-01-01

    The aim of this article is to reflect on the relationship between art and science so far as it concerns a symposium on neurosciences. We undertake a historical overview of that relationship, paying particular attention to the sui generis case of Leonardo da Vinci, who very often is regarded as the man who worked on art and science with equal ease. We then explain why his idea of merging these two forms of knowledge failed, considering the clear-cut distinction between art and science in his time. With this clarification, we explore the matter today. We look at Raphael's The Transfiguration, in which the representation of the possessed boy is seen by neuroscientists as indicative of an epileptic seizure. We also look at the ideas of neuroscientists Semir Zeki and Vilayanur Ramachandran, who study particular aspects of brain function and suggest a new merging of art and science.

  12. Quantitative Reasoning and the Sine Function: The Case of Zac

    ERIC Educational Resources Information Center

    Moore, Kevin C.

    2014-01-01

    A growing body of literature has identified quantitative and covariational reasoning as critical for secondary and undergraduate student learning, particularly for topics that require students to make sense of relationships between quantities. The present study extends this body of literature by characterizing an undergraduate precalculus…

  13. Organizational Conditions of Teacher Learning.

    ERIC Educational Resources Information Center

    Bassler, Otto; Hoover-Dempsey, Kathy

    1986-01-01

    This research examined 1,213 elementary school teachers' perceptions of the school organizational conditions that provide the greatest opportunities for professional development. Ten workplace conditions were analyzed. Results are presented. (Author/MT)

  14. CLASSICAL CONDITIONING AND PAIN: CONDITIONED ANALGESIA AND HYPERALGESIA

    PubMed Central

    Miguez, Gonzalo; Laborda, Mario A.; Miller, Ralph R.

    2013-01-01

    This article reviews situations in which stimuli produce an increase or a decrease in nociceptive responses through basic associative processes and provides an associative account of such changes. Specifically, the literature suggests that cues associated with stress can produce conditioned analgesia or conditioned hyperalgesia, depending on the properties of the conditioned stimulus (e.g., contextual cues and audiovisual cues vs. gustatory and olfactory cues, respectively) and the proprieties of the unconditioned stimulus (e.g., appetitive, aversive, or analgesic, respectively). When such cues are associated with reducers of exogenous pain (e.g., opiates), they typically increase sensitivity to pain. Overall, the evidence concerning conditioned stress-induced analgesia, conditioned hyperalagesia, conditioned tolerance to morphine, and conditioned reduction of morphine analgesia suggests that selective associations between stimuli underlie changes in pain sensitivity. PMID:24269884

  15. Classical conditioning and pain: conditioned analgesia and hyperalgesia.

    PubMed

    Miguez, Gonzalo; Laborda, Mario A; Miller, Ralph R

    2014-01-01

    This article reviews situations in which stimuli produce an increase or a decrease in nociceptive responses through basic associative processes and provides an associative account of such changes. Specifically, the literature suggests that cues associated with stress can produce conditioned analgesia or conditioned hyperalgesia, depending on the properties of the conditioned stimulus (e.g., contextual cues and audiovisual cues vs. gustatory and olfactory cues, respectively) and the proprieties of the unconditioned stimulus (e.g., appetitive, aversive, or analgesic, respectively). When such cues are associated with reducers of exogenous pain (e.g., opiates), they typically increase sensitivity to pain. Overall, the evidence concerning conditioned stress-induced analgesia, conditioned hyperalagesia, conditioned tolerance to morphine, and conditioned reduction of morphine analgesia suggests that selective associations between stimuli underlie changes in pain sensitivity.

  16. Operant Conditioning for Special Educators.

    ERIC Educational Resources Information Center

    Pedrini, Bonnie C.; Pedrini, D. T.

    The paper briefly explains operant conditioning as it pertains to special educators. Operant conditioning is thought to be an efficient method for modifying student behavior. Using the B. F. Skinner frame of reference, operant conditioning is said to include behavior modification and therapy, programed instruction, and computer assisted and…

  17. Teacher Working Conditions that Matter

    ERIC Educational Resources Information Center

    Leithwood, Ken; McAdie, Pat

    2007-01-01

    To advance understanding of the issues concerning teachers' working conditions, the Elementary Teachers' Federation of Ontario commissioned one of the authors to do an analytical review of literature on teachers' working conditions. This resulted in the publication, "Teacher Working Conditions That Matter: Evidence for Change." The framework for…

  18. Teaching and Demonstrating Classical Conditioning.

    ERIC Educational Resources Information Center

    Sparrow, John; Fernald, Peter

    1989-01-01

    Discusses classroom demonstrations of classical conditioning and notes tendencies to misrepresent Pavlov's procedures. Describes the design and construction of the conditioner that is used for demonstrating classical conditioning. Relates how students experience conditioning, generalization, extinction, discrimination, and spontaneous recovery.…

  19. Serotonin and conditioning: focus on Pavlovian psychostimulant drug conditioning.

    PubMed

    Carey, Robert J; Damianopoulos, Ernest N

    2015-04-01

    Serotonin containing neurons are located in nuclei deep in the brainstem and send axons throughout the central nervous system from the spinal cord to the cerebral cortex. The vast scope of these connections and interactions enable serotonin and serotonin analogs to have profound effects upon sensory/motor processes. In that conditioning represents a neuroplastic process that leads to new sensory/motor connections, it is apparent that the serotonin system has the potential for a critical role in conditioning. In this article we review the basics of conditioning as well as the serotonergic system and point up the number of non-associative ways in which manipulations of serotonin neurotransmission have an impact upon conditioning. We focus upon psychostimulant drug conditioning and review the contribution of drug stimuli in the use of serotonin drugs to investigate drug conditioning and the important impact drug stimuli can have on conditioning by introducing new sensory stimuli that can create or mask a CS. We also review the ways in which experimental manipulations of serotonin can disrupt conditioned behavioral effects but not the associative processes in conditioning. In addition, we propose the use of the recently developed memory re-consolidation model of conditioning as an approach to assess the possible role of serotonin in associative processes without the complexities of performance effects related to serotonin treatment induced alterations in sensory/motor systems.

  20. Air toxics evaluation of ABB Combustion Engineering Low-Emission Boiler Systems

    SciTech Connect

    Wesnor, J.D.

    1993-10-26

    The specific goals of the program are to identify air toxic compounds that might be emmitted from the new boiler with its various Air Pollution Control device for APCD alternatives in levels of regulatory concern. For the compounds thought to be of concern, potential air toxic control methodologies will be suggested and a Test Protocol will be written to be used in the Proof of Concept and full scale tests. The following task was defined: Define Replations and Standards; Identify Air Toxic Pollutants of Interest to Interest to Utility Boilers; Assesment of Air Toxic By-Products; State of the Art Assessment of Toxic By-Product Control Technologies; and Test Protocol Definition.

  1. Bending the Rules: Widefield Microscopy and the Abbe Limit of Resolution

    PubMed Central

    Verdaasdonk, Jolien S.; Stephens, Andrew D.; Haase, Julian; Bloom, Kerry

    2014-01-01

    One of the most fundamental concepts of microscopy is that of resolution–the ability to clearly distinguish two objects as separate. Recent advances such as structured illumination microscopy (SIM) and point localization techniques including photoactivated localization microscopy (PALM), and stochastic optical reconstruction microscopy (STORM) strive to overcome the inherent limits of resolution of the modern light microscope. These techniques, however, are not always feasible or optimal for live cell imaging. Thus, in this review, we explore three techniques for extracting high resolution data from images acquired on a widefield microscope–deconvolution, model convolution, and Gaussian fitting. Deconvolution is a powerful tool for restoring a blurred image using knowledge of the point spread function (PSF) describing the blurring of light by the microscope, although care must be taken to ensure accuracy of subsequent quantitative analysis. The process of model convolution also requires knowledge of the PSF to blur a simulated image which can then be compared to the experimentally acquired data to reach conclusions regarding its geometry and fluorophore distribution. Gaussian fitting is the basis for point localization microscopy, and can also be applied to tracking spot motion over time or measuring spot shape and size. All together, these three methods serve as powerful tools for high-resolution imaging using widefield microscopy. PMID:23893718

  2. ETV REPORT AND STATEMENT, ABB INC. BIOTEMP VETABLE OIL - BASED INSULATING DIELECTRIC FLUID

    EPA Science Inventory

    THE USEPA has created the ETV program to facilitate the deployment of innovative of improved environmental technologies through performance verification and information dissemination. The goal of the ETV Program is to further environmental protection by substantially acceleratin...

  3. Lemaître, Abbé Georges Edouard (1894-1966)

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    Priest, civil engineer and astrophysicist, born in Charleroi, Belgium, became professor of the theory of relativity at Louvain, researched on cosmic rays and the three-body problem. Proposed (1927) independently of FRIEDMANN, an evolving cosmological model in general relativity. This mathematical solution to the EINSTEIN equations, sought but not discovered by Einstein, indicated that the univers...

  4. Lacaille, Abbé Nicholas [Nicolas] Louis de (1713-62)

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    Astronomer, born in Rumigny, France. From 1750 to 1754 he led an expedition to the Cape of Good Hope, where he was the first to measure the curvature of the Earth in South Africa, and, with a small telescope, compiled a still-used catalogue of nearly 10 000 southern stars. In the course of his survey he discovered and listed 50 nebulous objects (eight are now regarded as non-existent). He classif...

  5. Photoluminescence studies of polycrystalline Cu(In,Ga)Se2: Lateral inhomogeneities beyond Abbe's diffraction limit

    NASA Astrophysics Data System (ADS)

    Neumann, Oliver; Brüggemann, Rudolf; Hariskos, Dimitrios; Witte, Wolfram; Bauer, Gottfried H.

    2015-11-01

    We analyze Cu(In,Ga)Se2 absorbers with a scanning near-field optical microscope (SNOM) by photoluminescence (PL). Such measurements allow one to extract local fluctuations of the integral PL yield, the quasi-Fermi level splitting, and the material composition in the submicron range. However, the experimental findings depend strongly on the surface roughness of the absorber: If the surface is rough, artifact-prone correlations between surface contour and PL features measured by SNOM can be found that complicate the study of recombination effects. For smooth surfaces, such correlations no longer exist and the influence of grain boundaries on the integral PL yield and the quasi-Fermi level splitting is revealed. The method also allows a detailed determination of the local band gaps in neighboring grains and their spatial variation inside, and thus of possibly local changes in chemical composition of different grains.

  6. Extended slow-roll conditions and rapid-roll conditions

    SciTech Connect

    Chiba, Takeshi; Yamaguchi, Masahide E-mail: gucci@phys.aoyama.ac.jp

    2008-10-15

    We derive slow-roll conditions for a scalar field which is non-minimally coupled with gravity in a consistent manner and express spectral indices of scalar/tensor perturbations in terms of the slow-roll parameters. The conformal invariance of the curvature perturbation is proved without linear approximations. Rapid-roll conditions are also derived, and the relation with the slow-roll conditions is discussed.

  7. Sensitivity to masked conditioned stimuli predicts conditioned response magnitude under masked conditions

    PubMed Central

    Cornwell, Brian R.; Echiverri, Aileen M.; Grillon, Christian

    2009-01-01

    Expression of conditioned fear has been reported to be independent of perceptual awareness of conditioned stimuli (CSs). Previous studies have been criticized, however, for not adequately assessing perceptual awareness. We fear-conditioned participants to one of two symbols and measured skin conductance responses to dichoptically masked and unmasked CSs. Participants also performed a target detection task and sensitivity (d′) to the masked conditioned stimuli (CS+, CS−) was measured. Results showed that sensitivity under masking conditions was related to conditioned responses to masked CSs but not unmasked CSs. Thus, a strong relationship between expression of conditioned fear and awareness of the CS+ emerges when the latter is assessed by signal detection methods. Without consensus on how awareness should be defined, these findings bring balance to previous studies that have typically used less sensitive assessments of awareness. PMID:17433097

  8. Extinction in human fear conditioning.

    PubMed

    Hermans, Dirk; Craske, Michelle G; Mineka, Susan; Lovibond, Peter F

    2006-08-15

    Although most extinction research is conducted in animal laboratories, the study of extinction learning in human fear conditioning has gained increasing attention over the last decade. The most important findings from human fear extinction are reviewed in this article. Specifically, we review experimental investigations of the impact of conditioned inhibitors, conditioned exciters, context renewal, and reinstatement on fear extinction in human samples. We discuss data from laboratory studies of the extinction of aversively conditioned stimuli, as well as results from experimental clinical work with fearful or anxious individuals. We present directions for future research, in particular the need for further investigation of differences between animal and human conditioning outcomes, and research examining the role of both automatic and higher-order cognitive processes in human conditioning and extinction.

  9. How People Interpret Conditionals: Shifts toward the Conditional Event

    ERIC Educational Resources Information Center

    Fugard, Andrew J. B.; Pfeifer, Niki; Mayerhofer, Bastian; Kleiter, Gernot D.

    2011-01-01

    We investigated how people interpret conditionals and how stable their interpretation is over a long series of trials. Participants were shown the colored patterns on each side of a 6-sided die and were asked how sure they were that a conditional holds of the side landing upward when the die is randomly thrown. Participants were presented with 71…

  10. Polarity in Conditionals and Conditional-Like Constructions

    ERIC Educational Resources Information Center

    Hsieh, I-Ta Chris

    2012-01-01

    This dissertation concerns the distribution of negative polarity items (henceforth, NPIs) in conditionals and conditional-like constructions. NPIs include words such as any and ever and idioms such as "give a damn" and "lift a finger"; these expressions have only a limited distribution. In this dissertation, the distribution of…

  11. Demand Characteristics in Classical Verbal Conditioning and Attitude Conditioning Studies.

    ERIC Educational Resources Information Center

    McGinley, Hugh

    This paper is a draft for the American Psychological Association Symposium on the conditioning of verbal behavior and attitudes. The author presents the results of several studies he conducted in the classical conditioning of meaning and attitude. These studies attempt to control the measurement effects created by extraneous variables operating on…

  12. Conditional entropy of ordinal patterns

    NASA Astrophysics Data System (ADS)

    Unakafov, Anton M.; Keller, Karsten

    2014-02-01

    In this paper we investigate a quantity called conditional entropy of ordinal patterns, akin to the permutation entropy. The conditional entropy of ordinal patterns describes the average diversity of the ordinal patterns succeeding a given ordinal pattern. We observe that this quantity provides a good estimation of the Kolmogorov-Sinai entropy in many cases. In particular, the conditional entropy of ordinal patterns of a finite order coincides with the Kolmogorov-Sinai entropy for periodic dynamics and for Markov shifts over a binary alphabet. Finally, the conditional entropy of ordinal patterns is computationally simple and thus can be well applied to real-world data.

  13. FPC conditioning cart at BNL

    SciTech Connect

    Xu, W.; Ben-Zvi, I.; Altinbas, F.Z.; Belomestnykh, S.; Burrill, A.; Cole, M.; Deonarine, J.; Jamilkowski, J.; Kayran, D.; Laloudakis, N.; Masi Jr, L.; McIntyre, G.; Pate, D.; Philips, D.; Seda, T.; Steszyn, A.; Tallerico, T.; Todd, R.; Weiss, D.; White, G.; Zaltsman, A.

    2011-03-28

    The 703 MHz superconducting gun for the BNL Energy Recovery Linac (ERL) prototype has two fundamental power couplers (FPCs), and each of them will deliver up to 500 kW of CW RF power. In order to prepare the couplers for high power RF service and process multipacting, the FPCs should be conditioned prior to installation into the gun cryomodule. A conditioning cart based test stand, which includes a vacuum pumping system, controllable bake-out system, diagnostics, interlocks and data log system has been designed, constructed and commissioned by collaboration of BNL and AES. This paper presents FPC conditioning cart systems and the conditioning process.

  14. Entanglement conditions and polynomial identities

    SciTech Connect

    Shchukin, E.

    2011-11-15

    We develop a rather general approach to entanglement characterization based on convexity properties and polynomial identities. This approach is applied to obtain simple and efficient entanglement conditions that work equally well in both discrete as well as continuous-variable environments. Examples of violations of our conditions are presented.

  15. Matching and Conditioned Reinforcement Rate

    ERIC Educational Resources Information Center

    Shahan, Timothy A.; Podlesnik, Christopher A.; Jimenez-Gomez, Corina

    2006-01-01

    Attempts to examine the effects of variations in relative conditioned reinforcement rate on choice have been confounded by changes in rates of primary reinforcement or changes in the value of the conditioned reinforcer. To avoid these problems, this experiment used concurrent observing responses to examine sensitivity of choice to relative…

  16. Operant conditioning in redwinged blackbirds.

    PubMed

    Bastian, C W; Hothersall, D

    1970-09-01

    An operant conditioning technique for use with passerine birds is described. Two redwinged blackbirds were successfully conditioned to perch-hop for food reinforcement. Continuous reinforcement and fixed-ratio schedules involving substantial ratio requirements were used to maintain this response. The behavior of the two redwinged blackbirds was comparable to that of more conventional organisms working on similar schedules of reinforcement.

  17. The National Wetland Condition Assessment

    EPA Science Inventory

    The first National Wetland Condition Assessment (NWCA) was conducted in 2011 by the US Environmental Protection Agency (USEPA). Vegetation, algae, soil, water chemistry,and hydrologic data were collected at each of 1138 sites across the contiguous US. Ecological condition was ass...

  18. Trace fear conditioning in mice.

    PubMed

    Lugo, Joaquin N; Smith, Gregory D; Holley, Andrew J

    2014-03-20

    In this experiment we present a technique to measure learning and memory. In the trace fear conditioning protocol presented here there are five pairings between a neutral stimulus and an unconditioned stimulus. There is a 20 sec trace period that separates each conditioning trial. On the following day freezing is measured during presentation of the conditioned stimulus (CS) and trace period. On the third day there is an 8 min test to measure contextual memory. The representative results are from mice that were presented with the aversive unconditioned stimulus (shock) compared to mice that received the tone presentations without the unconditioned stimulus. Trace fear conditioning has been successfully used to detect subtle learning and memory deficits and enhancements in mice that are not found with other fear conditioning methods. This type of fear conditioning is believed to be dependent upon connections between the medial prefrontal cortex and the hippocampus. One current controversy is whether this method is believed to be amygdala-independent. Therefore, other fear conditioning testing is needed to examine amygdala-dependent learning and memory effects, such as through the delay fear conditioning.

  19. Conditional Logic and Primary Children.

    ERIC Educational Resources Information Center

    Ennis, Robert H.

    Conditional logic, as interpreted in this paper, means deductive logic characterized by "if-then" statements. This study sought to investigate the knowledge of conditional logic possessed by primary children and to test their readiness to learn such concepts. Ninety students were designated the experimental group and participated in a 15-week…

  20. Study of the cofactor conditions: Conditions of supercompatibility between phases

    NASA Astrophysics Data System (ADS)

    Chen, Xian; Srivastava, Vijay; Dabade, Vivekanand; James, Richard D.

    2013-12-01

    The cofactor conditions, introduced in James and Zhang(2005), are conditions of compatibility between phases in martensitic materials. They consist of three subconditions: (i) the condition that the middle principal stretch of the transformation stretch tensor U is unity (λ2=1), (ii) the condition a·Ucof(U2-I)n=0, where the vectors a and n are certain vectors arising in the specification of the twin system, and (iii) the inequality trU2+det U2-(1/4)|a|2|n|2≥2. Together, these conditions are necessary and sufficient for the equations of the crystallographic theory of martensite to be satisfied for the given twin system but for any volume fraction f of the twins, 0≤f≤1. This contrasts sharply with the generic solutions of the crystallographic theory which have at most two such volume fractions for a given twin system of the form f* and 1-f*. In this paper we simplify the form of the cofactor conditions, we give their specific forms for various symmetries and twin types, we clarify the extent to which the satisfaction of the cofactor conditions for one twin system implies its satisfaction for other twin systems. In particular, we prove that the satisfaction of the cofactor conditions for either Type I or Type II twins implies that there are solutions of the crystallographic theory using these twins that have no elastic transition layer. We show that the latter further implies macroscopically curved, transition-layer-free austenite/martensite interfaces for Type I twins, and planar transition-layer-free interfaces for Type II twins which nevertheless permit significant flexibility (many deformations) of the martensite. We identify some real material systems nearly satisfying the cofactor conditions. Overall, the cofactor conditions are shown to dramatically increase the number of deformations possible in austenite/martensite mixtures without the presence of elastic energy needed for coexistence. In the context of earlier work that links the special case λ2

  1. Serotonin in fear conditioning processes.

    PubMed

    Bauer, Elizabeth P

    2015-01-15

    This review describes the latest developments in our understanding of how the serotonergic system modulates Pavlovian fear conditioning, fear expression and fear extinction. These different phases of classical fear conditioning involve coordinated interactions between the extended amygdala, hippocampus and prefrontal cortices. Here, I first define the different stages of learning involved in cued and context fear conditioning and describe the neural circuits underlying these processes. The serotonergic system can be manipulated by administering serotonin receptor agonists and antagonists, as well as selective serotonin reuptake inhibitors (SSRIs), and these can have significant effects on emotional learning and memory. Moreover, variations in serotonergic genes can influence fear conditioning and extinction processes, and can underlie differential responses to pharmacological manipulations. This research has considerable translational significance as imbalances in the serotonergic system have been linked to anxiety and depression, while abnormalities in the mechanisms of conditioned fear contribute to anxiety disorders.

  2. Conceptual Conditioning: Mechanisms Mediating Conditioning Effects on Pain.

    PubMed

    Jepma, Marieke; Wager, Tor D

    2015-11-01

    Classical conditioning can profoundly modify subsequent pain responses, but the mechanisms that drive this effect are unresolved. In pain-conditioning studies, cues are typically conditioned to primary aversive reinforcers; hence, subsequent pain modulation could reflect learned precognitive associations (i.e., those involving neural plasticity independent of expectations and other forms of conceptual thought) or conceptual expectancies. We isolated conceptual contributions using a thermal pain-conditioning procedure in which different conditioned stimulus (CS) cues were repeatedly paired with symbolic representations of high and low noxious heat. In a subsequent test phase, identical noxious stimuli evoked larger skin conductance responses (SCRs) and pain ratings when preceded by CS cues associated with high temperature than by those associated with low temperature. These effects were mediated by participants' self-reported expectancies. CS cues associated with high temperature also evoked larger anticipatory SCRs than did CS cues associated with low temperature, but larger anticipatory SCRs predicted smaller subsequent heat-evoked SCRs. These results provide novel evidence that conditioned modulation of pain physiology can be acquired through purely conceptual processes, and that self-reported expectancies and physiological threat responses have opposing effects on pain.

  3. Defeasible reasoning with legal conditionals.

    PubMed

    Gazzo Castañeda, Lupita Estefania; Knauff, Markus

    2016-04-01

    Valid conclusions can be defeated if people can think of conditions that prevent the consequent to occur although the antecedent is given. The goal of the present research was to investigate how people consider these conditions when reasoning with legal conditionals such as "If a person kills another human, then this person should be punished for manslaughter." In Experiments 1 and 2 legal conditionals were presented to participants together with exculpatory circumstances, i.e., counterexamples. The participants' task was to decide whether they would adhere to the legal conditional rule and punish the offender. Participants were either lawyers (i.e., advanced law students and graduate lawyers) or legal laypeople. We found that laypeople often ignore exculpatory circumstances and adhere to the conditional rule when offences evoked high levels of moral outrage. Lawyers did not show this effect. In Experiment 3 laypeople showed difficulties even when asked to simply imagine exculpatory circumstances for highly morally outrageous offences. Results provide new evidence for the role of emotions--like moral outrage--in the consideration of counterexamples to legal conditionals. PMID:26689704

  4. Compatibility Conditions of Structural Mechanics

    NASA Technical Reports Server (NTRS)

    Patnaik, Surya N.; Coroneos, Rula M.; Hopkins, Dale A.

    1999-01-01

    The theory of elasticity has camouflaged a deficiency in the compatibility formulation since 1860. In structures the ad hoc compatibility conditions through virtual "cuts" and closing "gaps" are not parallel to the strain formulation in elasticity. This deficiency in the compatibility conditions has prevented the development of a direct stress determination method in structures and in elasticity. We have addressed this deficiency and attempted to unify the theory of compatibility. This work has led to the development of the integrated force method for structures and the completed Beltrami-Michell formulation for elasticity. The improved accuracy observed in the solution of numerical examples by the integrated force method can be attributed to the compliance of the compatibility conditions. Using the compatibility conditions allows mapping of variables and facile movement among different structural analysis formulations. This paper reviews and illustrates the requirement of compatibility in structures and in elasticity. It also describes the generation of the conditions and quantifies the benefits of their use. The traditional analysis methods and available solutions (which have been obtained bypassing the missed conditions) should be verified for compliance of the compatibility conditions.

  5. GALIC: Galaxy initial conditions construction

    NASA Astrophysics Data System (ADS)

    Yurin, Denis; Springel, Volker

    2014-08-01

    GalIC (GALaxy Initial Conditions) is an implementation of an iterative method to construct steady state composite halo-disk-bulge galaxy models with prescribed density distribution and velocity anisotropy that can be used as initial conditions for N-body simulations. The code is parallelized for distributed memory based on MPI. While running, GalIC produces "snapshot files" that can be used as initial conditions files. GalIC supports the three file formats ('type1' format, the slightly improved 'type2' format, and an HDF5 format) of the GADGET (ascl:0003.001) code for its output snapshot files.

  6. Mass-based condition measures and their relationship with fitness: in what condition is condition?

    PubMed Central

    Barnett, Craig A.; Suzuki, Toshitaka N.; Sakaluk, Scott K.; Thompson, Charles F.

    2015-01-01

    Mass or body-size measures of ‘condition’ are of central importance to the study of ecology and evolution, and it is often assumed that differences in condition measures are positively and linearly related to fitness. Using examples drawn from ecological studies, we show that indices of condition frequently are unlikely to be related to fitness in a linear fashion. Researchers need to be more explicit in acknowledging the limitations of mass-based condition measures and accept that, under some circumstances, they may not relate to fitness as traditionally assumed. Any relationship between a particular condition measure and fitness should first be empirically validated before condition is used as a proxy for fitness. In the absence of such evidence, researchers should explicitly acknowledge that assuming such a relationship may be unrealistic. PMID:26019406

  7. Active microstructured x-ray optical arrays

    NASA Astrophysics Data System (ADS)

    Michette, Alan G.; Pfauntsch, Slawka J.; Sahraei, Shahin; Shand, Matthew; Morrison, Graeme R.; Hart, David; Vojnovic, Boris; Stevenson, Tom; Parkes, William; Dunare, Camelia; Willingale, Richard; Feldman, Charlotte H.; Button, Tim W.; Zhang, Dou; Rodriguez-Sanmartin, Daniel; Wang, Hongchang; Smith, Andy D.

    2009-05-01

    The UK Smart X-Ray Optics consortium is developing novel reflective adaptive/active x-ray optics for small-scale laboratory applications, including studies of radiation-induced damage to biological material. The optics work on the same principle as polycapillaries, using configured arrays of channels etched into thin silicon, such that each x-ray photon reflects at most once off a channel wall. Using two arrays in succession provides two reflections and thus the Abbe sine condition can be approximately satisfied, reducing aberrations. Adaptivity is achieved by flexing one or both arrays using piezo actuation, which can provide further reduction of aberrations as well as controllable focal lengths. Modelling of such arrays for used on an x-ray microprobe, based on a microfocus source with an emitting region approximately 1μm in diameter, shows that a focused flux approximately two orders of magnitude greater than possible with a zone plate of comparable focal length is possible, assuming that the channel wall roughness is less than about 2nm.

  8. Review of active optics methods in astronomy from x-rays to the infrared

    NASA Astrophysics Data System (ADS)

    Lemaitre, Gérard R.

    2010-09-01

    This review on Active Optics Methods presents various concepts of deformable uv, visible and ir telescope optics which have been mainly developed at the Marseille Observatory - for now 40 years - and other institutes. An optical surface generated by active optics and spherical figuring is free from high spatial frequency errors i.e. ripple errors. Active Optics allows applications of new concepts as: stress figuring aspherization processes, variable curvature mirrors, in situ stressing aspherization processes, under stress replications to generate corrected diffraction gratings, multimode deformable compensators, and situ control of large telescope optics. X-ray telescope mirrors could also benefit soon from the enhanced imaging performances of active optics. The 0.5- 1 arcsec spatial resolution of Chandra should be followed up by increased resolution space telescopes. This requires constructing new grazing-incidence telescopes which will strictly satisfy Abbe's sine condition, i.e. a Chase-VanSpeybroeck design for the two-mirror case. The recent elaboration of an elasticity theory of weakly conical shells allows reviewing some potential innovative concepts for the active figuring and in situ control of either monolithic or segmented telescope mirrors for x-ray astronomy.

  9. Scanning properties of large dual-shaped offset and symmetric reflector antennas

    NASA Technical Reports Server (NTRS)

    Galindo-Israel, Victor; Veruttipong, Watt; Norrod, Roger D.; Imbriale, William A.

    1992-01-01

    Several characteristics of dual offset (DOSR) and symmetric shaped reflectors are examined. Among these is the amelioration of the added cost of manufacturing a shaped reflector antenna, particularly a doubly curved surface for the DOSR, if adjustable panels, which may be necessary for correction of gravity and wind distortions, are also used for improving gain by shaping. The scanning properties of shaped reflectors, both offset and circularly symmetric, are examined and compared to conic section scanning characteristics. Scanning of the pencil beam is obtained by lateral and axial translation of a single point-source feed. The feed is kept pointed toward the center of the subreflector. The effects of power spillover and aperture phase error as a function of beam scanning is examined for several different types of large reflector designs including DOSR, circularly symmetric large f/D and smaller f/D dual reflector antenna systems. It is graphically illustrated that the Abbe-sine condition for improving scanning of an optical system cannot, inherently, be satisfied in a dual-shaped reflector system shaped for high gain and low feed spillover.

  10. Design of axisymmetric multi-mirror grazing incidence system to increase the numerical aperture of neutron and X-ray microscopes

    NASA Astrophysics Data System (ADS)

    Aoki, Sadao; Watanabe, Norio; Asami, Hiroshi; Shimada, Akihiro

    2016-04-01

    An axisymmetric multi-mirror system for neutron and X-ray microscopes is proposed to increase their numerical aperture and collection efficiency. A Wolter type-I mirror is used as the basis of the multi-mirror system at grazing incidence. The addition of an even number of hyperboloid mirrors to the Wolter type-I mirror can satisfy both an equal optical path length and Abbe's sine condition. The numerical aperture increases in proportion to the number of mirrors. The optical parameters of the system with four tandem mirrors are calculated for neutrons and X-rays with a wavelength of 0.4 nm by assuming that the average grazing angle of incidence is 5.4 mrad and the magnification is 10. The inner diameters of the mirrors are limited to <10 mm considering the total length of the optical system. Tolerance of off-axis distance was calculated using a ray-tracing computer simulation. Ray tracing shows that a blur size <14 nm will be possible at an off-axis displacement of 10 μm.

  11. Plant Condition Remote Monitoring Technique

    NASA Technical Reports Server (NTRS)

    Fotedar, L. K.; Krishen, K.

    1996-01-01

    This paper summarizes the results of a radiation transfer study conducted on houseplants using controlled environmental conditions. These conditions included: (1) air and soil temperature; (2) incident and reflected radiation; and (3) soil moisture. The reflectance, transmittance, and emittance measurements were conducted in six spectral bands: microwave, red, yellow, green, violet and infrared, over a period of three years. Measurements were taken on both healthy and diseased plants. The data was collected on plants under various conditions which included: variation in plant bio-mass, diurnal variation, changes in plant pathological conditions (including changes in water content), different plant types, various disease types, and incident light wavelength or color. Analysis of this data was performed to yield an algorithm for plant disease from the remotely sensed data.

  12. Conditioning biomass for microbial growth

    DOEpatents

    Bodie, Elizabeth A; England, George

    2015-03-31

    The present invention relates to methods for improving the yield of microbial processes that use lignocellulose biomass as a nutrient source. The methods comprise conditioning a composition comprising lignocellulose biomass with an enzyme composition that comprises a phenol oxidizing enzyme. The conditioned composition can support a higher rate of growth of microorganisms in a process. In one embodiment, a laccase composition is used to condition lignocellulose biomass derived from non-woody plants, such as corn and sugar cane. The invention also encompasses methods for culturing microorganisms that are sensitive to inhibitory compounds in lignocellulose biomass. The invention further provides methods of making a product by culturing the production microorganisms in conditioned lignocellulose biomass.

  13. 8 Conditions for Motivated Learning

    ERIC Educational Resources Information Center

    Cushman, Kathleen

    2014-01-01

    The author interviewed hundreds of adolescents about what makes them interested in learning, in and out of school. The result is a formula hinging on creating eight conditions that spur kids to take active, motivated roles in their own learning.

  14. 76 FR 14600 - Dental Conditions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-17

    ... examination to be needed, and Application for treatment is received within 180 days of discharge, and A VA... treatment of periodontal disease or calculus, unless the condition meets regulatory eligibility criteria....

  15. Matching and conditioned reinforcement rate.

    PubMed

    Shahan, Timothy A; Podlesnik, Christopher A; Jimenez-Gomez, Corina

    2006-03-01

    Attempts to examine the effects of variations in relative conditioned reinforcement rate on choice have been confounded by changes in rates of primary reinforcement or changes in the value of the conditioned reinforcer. To avoid these problems, this experiment used concurrent observing responses to examine sensitivity of choice to relative conditioned reinforcement rate. In the absence of observing responses, unsignaled periods of food delivery on a variable-interval 90-s schedule alternated with extinction on a center key (i.e., a mixed schedule was in effect). Two concurrently available observing responses produced 15-s access to a stimulus differentially associated with the schedule of food delivery (S+). The relative rate of S+ deliveries arranged by independent variable-interval schedules for the two observing responses varied across conditions. The relation between the ratio of observing responses and the ratio of S+ deliveries was well described by the generalized matching law, despite the absence of changes in the rate of food delivery. In addition, the value of the S+ deliveries likely remained constant across conditions because the ratio of S+ to mixed schedule food deliveries remained constant. Assuming that S+ deliveries serve as conditioned reinforcers, these findings are consistent with the functional similarity between primary and conditioned reinforcers suggested by general choice theories based on the concatenated matching law (e.g., contextual choice and hyperbolic value-added models). These findings are inconsistent with delay reduction theory, which has no terms for the effects of rate of conditioned reinforcement in the absence of changes in rate of primary reinforcement.

  16. [Early Development under Microgravity Conditions].

    PubMed

    Ogneva, I V

    2015-01-01

    The review is devoted to various aspects of early development under the space flight conditions. The different possible cell mechanosensors are considered. Structural and functional changes in the cells, predominantly, in non-muscle ones, were discussed. The results of the different experiments with the embryos of fish, amphibians, birds and mammals under microgravity conditions are shown discussing possible reasons for the development of morphological changes. PMID:26591615

  17. Blood circulation under weightless conditions

    NASA Technical Reports Server (NTRS)

    Kasyan, I. I.; Kopanev, V. I.; Yazdovskiy, V. I.

    1975-01-01

    Biomedical data obtained on men and animals during weightlessness conditions establish instabilities in pulse rate and blood circulation that smooth out in proportion to adaptation to the weightless condition. The unusual slowness of recovery of pulse rate to initial values after space flight stress is attributed to biological simulation of hormonal shifts and discharge of humoral substances into the blood that prevent a rapid recovery of some biological indicators to initial values.

  18. Air conditioning and refrigeration engineering

    SciTech Connect

    Kreith, F.

    1999-12-01

    This book supplies the basics of design, from selecting the optimum system and equipment to preparing the drawings and specifications. It discusses the four phases of preparing a project: gathering information, developing alternatives, evaluating alternatives, and selling the best solution. In addition, the author breaks down the responsibilities of the engineer design documents, computer aided design, and government codes and standards. It provides you with an easy reference to all aspects of the topic. This resource addresses the most current areas of interest, such as computer aided design and drafting, desiccant air conditioning and energy conservation. It is a thorough and convenient guide to air conditioning and refrigeration engineering. Contents include: introduction; psychrometrics; air-conditioning processes and cycles; refrigerants and refrigeration cycles; outdoor design conditions and indoor design criteria; load calculations; air handling units and packaged units; refrigeration components and evaporative coolers; water systems; heating systems; refrigeration systems; thermal storage system; air system basics; absorption systems; air-conditioning systems and selection; and desiccant dehumidification and air-conditioning.

  19. Initial conditions for bubble universes

    NASA Astrophysics Data System (ADS)

    McInnes, Brett

    2008-06-01

    The “bubble universes” of Coleman and De Luccia play a crucial role in string cosmology. Since our own Universe is supposed to be of this kind, bubble cosmology should supply definite answers to the long-standing questions regarding cosmological initial conditions. In particular, it must explain how an initial singularity is avoided, and also how the initial conditions for inflation were established. I argue that the simplest nonanthropic approach to these problems involves a requirement that the spatial sections defined by distinguished bubble observers should not be allowed to have arbitrarily small volumes. Casimir energy is a popular candidate for a quantum effect which can ensure this, but (because it violates energy conditions) there is a danger that it could lead to nonperturbative instabilities in string theory. I make a simple proposal for the initial conditions of a bubble universe, and show that my proposal ensures that the system is nonperturbatively stable. Thus, low-entropy conditions can be established at the beginning of a bubble universe without violating the second law of thermodynamics and without leading to instability in string theory. These conditions are inherited from the ambient spacetime.

  20. Monetary effects on fear conditioning.

    PubMed

    Qu, Chen; Zhang, Aiyi; Chen, Qishan

    2013-04-01

    Previous research has found that the loss of money as a negative secondary reinforcer was as effective as a primary reinforcer during fear conditioning. The purpose of the present study was to explore the effect of monetary gain as a positive secondary reinforcer in fear conditioning. Participants were assigned to a high-reward group or low-reward group. Three kinds of squares prompting non-compensation shock, compensation shock, and no shock were presented. Skin conductance responses (SCRs) and self-ratings were recorded. The results revealed that (a) both SCRs and self-ratings in the compensation shock condition were lower than in the non-compensation shock condition, suggesting that money might block the learning stage of fear conditioning; and (b) a higher ratio of fear reduction was present in self-rating when compared to SCRs, suggesting that people might overstate the utility of money, subjectively. Monetary effects, the effects of different amounts of money, and the differences between subjective and physiological levels are discussed.

  1. Conditioned sounds enhance visual processing.

    PubMed

    Leo, Fabrizio; Noppeney, Uta

    2014-01-01

    This psychophysics study investigated whether prior auditory conditioning influences how a sound interacts with visual perception. In the conditioning phase, subjects were presented with three pure tones ( =  conditioned stimuli, CS) that were paired with positive, negative or neutral unconditioned stimuli. As unconditioned reinforcers we employed pictures (highly pleasant, unpleasant and neutral) or monetary outcomes (+50 euro cents, -50 cents, 0 cents). In the subsequent visual selective attention paradigm, subjects were presented with near-threshold Gabors displayed in their left or right hemifield. Critically, the Gabors were presented in synchrony with one of the conditioned sounds. Subjects discriminated whether the Gabors were presented in their left or right hemifields. Participants determined the location more accurately when the Gabors were presented in synchrony with positive relative to neutral sounds irrespective of reinforcer type. Thus, previously rewarded relative to neutral sounds increased the bottom-up salience of the visual Gabors. Our results are the first demonstration that prior auditory conditioning is a potent mechanism to modulate the effect of sounds on visual perception.

  2. Enhanced flue gas conditioning study

    SciTech Connect

    Miller, S.J.; Laudal, D.L.

    1991-11-01

    Many electrostatic precipitators (ESPS) do not achieve acceptable particulate removal efficiencies because of high-resistivity ash. One method to improve ESP performance is to employ chemical conditioning agents to reduce fly ash resistivity. Widely used agents include sulfur trioxide (SO[sub 3]) and ammonia, which are sometimes used simultaneously. For some fly ashes, that have a low affinity for SO[sub 3], conditioning with SO[sub 3] alone is not adequate to reduce resistivity without excessive amounts of SO[sub 3] exiting the stack. In such cases, the use of ammonia in addition to SO[sub 3] may reduce the amount of required SO[sub 3] and prevent the emission of excess SO[sub 3] out of the stack. The general objective of the work was to test enhanced flue gas conditioning methods to improve the performance of ESPS. Specific objectives were to (1) verify the relationship between the required SO[sub 3] injection rates to maintain the desired fly ash resistivity and temperature for four coals, (2) verify that dual conditioning with both ammonia and SO[sub 3] promotes SO[sub 3] utilization and allows for resistivity modification with moderate SO[sub 3] injection rates, and (3) verify the effectiveness and practicality of an enhanced flue gas conditioning (EFGC) method. The EFGC method is a proprietary development of Wahlco, Inc.

  3. Conditioned Sounds Enhance Visual Processing

    PubMed Central

    Leo, Fabrizio; Noppeney, Uta

    2014-01-01

    This psychophysics study investigated whether prior auditory conditioning influences how a sound interacts with visual perception. In the conditioning phase, subjects were presented with three pure tones ( =  conditioned stimuli, CS) that were paired with positive, negative or neutral unconditioned stimuli. As unconditioned reinforcers we employed pictures (highly pleasant, unpleasant and neutral) or monetary outcomes (+50 euro cents, −50 cents, 0 cents). In the subsequent visual selective attention paradigm, subjects were presented with near-threshold Gabors displayed in their left or right hemifield. Critically, the Gabors were presented in synchrony with one of the conditioned sounds. Subjects discriminated whether the Gabors were presented in their left or right hemifields. Participants determined the location more accurately when the Gabors were presented in synchrony with positive relative to neutral sounds irrespective of reinforcer type. Thus, previously rewarded relative to neutral sounds increased the bottom-up salience of the visual Gabors. Our results are the first demonstration that prior auditory conditioning is a potent mechanism to modulate the effect of sounds on visual perception. PMID:25192387

  4. Conditioning across the duration of a backward conditioned stimulus.

    PubMed

    Romaniuk, C B; Williams, D A

    2000-10-01

    Five conditioned suppression experiments examined the extent to which an appetitively motivated lever-press response can be punished by different components of a backward conditioned stimulus (CS). Using a 0-s unconditioned stimulus (US)-CS interval, Experiments 1 and 2 showed that the initial 3 s of a normally 30-s backward CS served as a more effective punisher than the CS as a whole. Experiment 3 found no such effect if the US-CS interval were 3 s rather than 0 s. Experiments 4A and 4B found that if the US-CS interval were 0 s, the initial part of the backward CS acquired excitatory properties although the CS as a whole passed a summation test for conditioned inhibition. By contrast, the 3-s US-CS interval supported inhibitory conditioning across the whole duration of the backward CS. Taken together, these findings support a modified version of Wagner's sometimes opponent process model, which suggests that different components of a backward CS become either excitatory or inhibitory depending on the components' temporal proximity to the US. PMID:11056885

  5. Condition with Caution: Think Thrice Before Conditioning. (Rough Draft).

    ERIC Educational Resources Information Center

    Katz, Lilian G.

    1971-01-01

    Innovative models for education are often quickly adopted. Behavior modification, or operant conditioning, is an example of a technique which has been widely used because, when properly applied in the classroom, it "works." However, the application of a technique should be carefully thought through in terms of the meaning of the behavior in…

  6. Oil Analysis and Condition Monitoring

    NASA Astrophysics Data System (ADS)

    Toms, A.; Toms, L.

    Lubricants are essential and expensive components of machine systems needing sampling, analysis and monitoring. Monitoring can be either performance testing or oil condition monitoring. Knowledge of the system's critical failure modes is essential for cost-effective oil and machinery monitoring. Contamination occurs by water, fuel, glycol, dirt, wrong oil, metal particulate, soot, oil degradation and additive depletion. Oil test methods include in situ or laboratory FT-IR, electronic particle counting, elemental metal measurement, X-ray fluorescence, viscosity, gas chromatography, water determination and RULER®. Condition monitoring data must be managed by storage, analysis and interpretation. Status levels must be established from the database and reported upon for individual and sequential runs of samples as condition indicators.

  7. Conditioned Reinforcement and Response Strength

    PubMed Central

    Shahan, Timothy A

    2010-01-01

    Stimuli associated with primary reinforcers appear themselves to acquire the capacity to strengthen behavior. This paper reviews research on the strengthening effects of conditioned reinforcers within the context of contemporary quantitative choice theories and behavioral momentum theory. Based partially on the finding that variations in parameters of conditioned reinforcement appear not to affect response strength as measured by resistance to change, long-standing assertions that conditioned reinforcers do not strengthen behavior in a reinforcement-like fashion are considered. A signposts or means-to-an-end account is explored and appears to provide a plausible alternative interpretation of the effects of stimuli associated with primary reinforcers. Related suggestions that primary reinforcers also might not have their effects via a strengthening process are explored and found to be worthy of serious consideration. PMID:20885815

  8. Diffusions conditioned on occupation measures

    NASA Astrophysics Data System (ADS)

    Angeletti, Florian; Touchette, Hugo

    2016-02-01

    A Markov process fluctuating away from its typical behavior can be represented in the long-time limit by another Markov process, called the effective or driven process, having the same stationary states as the original process conditioned on the fluctuation observed. We construct here this driven process for diffusions spending an atypical fraction of their evolution in some region of state space, corresponding mathematically to stochastic differential equations conditioned on occupation measures. As an illustration, we consider the Langevin equation conditioned on staying for a fraction of time in different intervals of the real line, including the positive half-line which leads to a generalization of the Brownian meander problem. Other applications related to quasi-stationary distributions, metastable states, noisy chemical reactions, queues, and random walks are discussed.

  9. Quantum Measurement and Initial Conditions

    NASA Astrophysics Data System (ADS)

    Stoica, Ovidiu Cristinel

    2016-03-01

    Quantum measurement finds the observed system in a collapsed state, rather than in the state predicted by the Schrödinger equation. Yet there is a relatively spread opinion that the wavefunction collapse can be explained by unitary evolution (for instance in the decoherence approach, if we take into account the environment). In this article it is proven a mathematical result which severely restricts the initial conditions for which measurements have definite outcomes, if pure unitary evolution is assumed. This no-go theorem remains true even if we take the environment into account. The result does not forbid a unitary description of the measurement process, it only shows that such a description is possible only for very restricted initial conditions. The existence of such restrictions of the initial conditions can be understood in the four-dimensional block universe perspective, as a requirement of global self-consistency of the solutions of the Schrödinger equation.

  10. Conditioned reinforcement and response strength.

    PubMed

    Shahan, Timothy A

    2010-03-01

    Stimuli associated with primary reinforcers appear themselves to acquire the capacity to strengthen behavior. This paper reviews research on the strengthening effects of conditioned reinforcers within the context of contemporary quantitative choice theories and behavioral momentum theory. Based partially on the finding that variations in parameters of conditioned reinforcement appear not to affect response strength as measured by resistance to change, long-standing assertions that conditioned reinforcers do not strengthen behavior in a reinforcement-like fashion are considered. A signposts or means-to-an-end account is explored and appears to provide a plausible alternative interpretation of the effects of stimuli associated with primary reinforcers. Related suggestions that primary reinforcers also might not have their effects via a strengthening process are explored and found to be worthy of serious consideration.

  11. Structural lubricity under ambient conditions

    PubMed Central

    Cihan, Ebru; İpek, Semran; Durgun, Engin; Baykara, Mehmet Z.

    2016-01-01

    Despite its fundamental importance, physical mechanisms that govern friction are poorly understood. While a state of ultra-low friction, termed structural lubricity, is expected for any clean, atomically flat interface consisting of two different materials with incommensurate structures, some associated predictions could only be quantitatively confirmed under ultra-high vacuum (UHV) conditions so far. Here, we report structurally lubric sliding under ambient conditions at mesoscopic (∼4,000–130,000 nm2) interfaces formed by gold islands on graphite. Ab initio calculations reveal that the gold–graphite interface is expected to remain largely free from contaminant molecules, leading to structurally lubric sliding. The experiments reported here demonstrate the potential for practical lubrication schemes for micro- and nano-electromechanical systems, which would mainly rely on an atomic-scale structural mismatch between the slider and substrate components, via the utilization of material systems featuring clean, atomically flat interfaces under ambient conditions. PMID:27350035

  12. Eckart−Sayvetz conditions revisited

    SciTech Connect

    Szalay, Viktor

    2014-06-21

    It is shown that vibrational displacements satisfying the Eckart−Sayvetz conditions can be constructed by projection of unconstrained displacements. This result has a number of interesting direct and indirect ramifications: (i) The normal coordinates corresponding to an electronic state or an isotopologue of a molecule are transformed to those of another state or isotopologue by a linear and, in general, non-orthogonal transformation. (ii) Novel interpretation of axis switching. (iii) One may enhance the separation of rotational-large-amplitude internal motions and the vibrational motions beyond that offered by the standard use of the Eckart−Sayvetz conditions. (iv) The rotational-vibrational Hamiltonian given in terms of curvilinear internal coordinates may be derived with elementary mathematical tools while taking into account the Eckart conditions with or without enhancement.

  13. Motor activity under weightless conditions

    NASA Technical Reports Server (NTRS)

    Kasyan, I. I.; Kopanev, V. I.; Cherepakhin, M. A.; Yuganov, Y. M.

    1975-01-01

    The material presented on the motor activity under weightless conditions (brief and long) leads to the conclusion that it is not significantly disrupted, if those being examined are secured at the workplaces. Some discoordination of movement, moderately expressed disruption of the precision of reproduction of assigned muscular forces, etc., were observed. Motor disorders decrease significantly in proportion to the length of stay under weightless conditions. This apparently takes place, as a consequence of formation of a new functional system, adequate to the conditions of weightlessness. Tests on intact and labyrinthectomized animals have demonstrated that signaling from the inner ear receptors is superfluous in weightlessness, since it promotes the onset of disruptions in the combined work of the position analyzers.

  14. Conditioned reinforcement and response strength.

    PubMed

    Shahan, Timothy A

    2010-03-01

    Stimuli associated with primary reinforcers appear themselves to acquire the capacity to strengthen behavior. This paper reviews research on the strengthening effects of conditioned reinforcers within the context of contemporary quantitative choice theories and behavioral momentum theory. Based partially on the finding that variations in parameters of conditioned reinforcement appear not to affect response strength as measured by resistance to change, long-standing assertions that conditioned reinforcers do not strengthen behavior in a reinforcement-like fashion are considered. A signposts or means-to-an-end account is explored and appears to provide a plausible alternative interpretation of the effects of stimuli associated with primary reinforcers. Related suggestions that primary reinforcers also might not have their effects via a strengthening process are explored and found to be worthy of serious consideration. PMID:20885815

  15. Structural lubricity under ambient conditions

    NASA Astrophysics Data System (ADS)

    Cihan, Ebru; Ipek, Semran; Durgun, Engin; Baykara, Mehmet Z.

    2016-06-01

    Despite its fundamental importance, physical mechanisms that govern friction are poorly understood. While a state of ultra-low friction, termed structural lubricity, is expected for any clean, atomically flat interface consisting of two different materials with incommensurate structures, some associated predictions could only be quantitatively confirmed under ultra-high vacuum (UHV) conditions so far. Here, we report structurally lubric sliding under ambient conditions at mesoscopic (~4,000-130,000 nm2) interfaces formed by gold islands on graphite. Ab initio calculations reveal that the gold-graphite interface is expected to remain largely free from contaminant molecules, leading to structurally lubric sliding. The experiments reported here demonstrate the potential for practical lubrication schemes for micro- and nano-electromechanical systems, which would mainly rely on an atomic-scale structural mismatch between the slider and substrate components, via the utilization of material systems featuring clean, atomically flat interfaces under ambient conditions.

  16. Structural lubricity under ambient conditions.

    PubMed

    Cihan, Ebru; İpek, Semran; Durgun, Engin; Baykara, Mehmet Z

    2016-01-01

    Despite its fundamental importance, physical mechanisms that govern friction are poorly understood. While a state of ultra-low friction, termed structural lubricity, is expected for any clean, atomically flat interface consisting of two different materials with incommensurate structures, some associated predictions could only be quantitatively confirmed under ultra-high vacuum (UHV) conditions so far. Here, we report structurally lubric sliding under ambient conditions at mesoscopic (∼4,000-130,000 nm(2)) interfaces formed by gold islands on graphite. Ab initio calculations reveal that the gold-graphite interface is expected to remain largely free from contaminant molecules, leading to structurally lubric sliding. The experiments reported here demonstrate the potential for practical lubrication schemes for micro- and nano-electromechanical systems, which would mainly rely on an atomic-scale structural mismatch between the slider and substrate components, via the utilization of material systems featuring clean, atomically flat interfaces under ambient conditions. PMID:27350035

  17. Initial conditions and quantum cosmology

    NASA Technical Reports Server (NTRS)

    Hartle, James B.

    1987-01-01

    A theory of initial conditions is necessary for a complete explanation of the presently observed large scale structural features of the universe, and a quantum theory of cosmology is probably needed for its formulation. The kinematics of quantum cosmology are reviewed, and some candidates for a law of initial conditions are discussed. The proposal that the quantum state of a closed universe is the natural analog of the ground state for closed cosmologies and is specified by a Euclidean sum over histories is sketched. When implemented in simple models, this proposal is consistent with the most important large-scale observations.

  18. Real-time streamflow conditions

    USGS Publications Warehouse

    Graczyk, David J.; Gebert, Warren A.

    1996-01-01

    Would you like to know streamflow conditions before you go fishing in Wisconsin or in more distant locations? Real-time streamflow data throughout Wisconsin and the United States are available on the Internet from the U.S. Geological Survey. You can see if the stream you are interested in fishing is high due to recent rain or low because of an extended dry spell. Flow conditions at more than 100 stream-gaging stations located throughout Wisconsin can be viewed by accessing the Wisconsin District Home Page at: http://wwwdwimdn.er.usgs.gov

  19. Making chromosome abnormalities treatable conditions.

    PubMed

    Cody, Jannine DeMars; Hale, Daniel Esten

    2015-09-01

    Individuals affected by the classic chromosome deletion syndromes which were first identified at the beginning of the genetic age, are now positioned to benefit from genomic advances. This issue highlights five of these conditions (4p-, 5p-, 11q-, 18p-, and 18q-). It focuses on the increased in understanding of the molecular underpinnings and envisions how these can be transformed into effective treatments. While it is scientifically exciting to see the phenotypic manifestations of hemizygosity being increasingly understood at the molecular and cellular level, it is even more amazing to consider that we are now on the road to making chromosome abnormalities treatable conditions.

  20. Heat pipe thermal conditioning panel

    NASA Technical Reports Server (NTRS)

    Saaski, E. W.; Loose, J. D.; Mccoy, K. E.

    1974-01-01

    Thermal control of electronic hardware and experiments on future space vehicles is critical to proper functioning and long life. Thermal conditioning panels (cold plates) are a baseline control technique in current conceptual studies. Heat generating components mounted on the panels are typically cooled by fluid flowing through integral channels within the panel. However, replacing the pumped fluid coolant loop within the panel with heat pipes offers attractive advantages in weight, reliability, and installation. This report describes the development and fabrication of two large 0.76 x 0.76 m heat pipe thermal conditioning panels to verify performance and establish the design concept.

  1. Extreme Conditions Modeling Workshop Report

    SciTech Connect

    Coe, R. G.; Neary, V. S.; Lawson, M. J.; Yu, Y.; Weber, J.

    2014-07-01

    Sandia National Laboratories (SNL) and the National Renewable Energy Laboratory (NREL) hosted the Wave Energy Converter (WEC) Extreme Conditions Modeling (ECM) Workshop in Albuquerque, NM on May 13th-14th, 2014. The objective of the workshop was to review the current state of knowledge on how to model WECs in extreme conditions (e.g. hurricanes and other large storms) and to suggest how U.S. Department of Energy (DOE) and national laboratory resources could be used to improve ECM methods for the benefit of the wave energy industry.

  2. Principles of Cognitive-Behavioral Therapy for Bulimia Nervosa.

    ERIC Educational Resources Information Center

    Garner, David M.; Davis, Ron

    1986-01-01

    Outlines a cognitive-behavioral approach to treating bulimia, focusing on the client's eating behavior, physical condition, and dysfunctional attitudes responsible for deficiencies in self-concept. (Author/ABB)

  3. Associations in Human Instrumental Conditioning

    ERIC Educational Resources Information Center

    Gamez, A. Matias; Rosas, Juan M.

    2007-01-01

    Four experiments were conducted to study the contents of human instrumental conditioning. Experiment 1 found positive transfer between a discriminative stimulus (S[superscript D] and an instrumental response (R) that shared the outcome (O) with the response that was originally trained with the S[superscript D], showing the formation of an…

  4. How Cells Endure Extreme Conditions

    SciTech Connect

    2009-01-01

    One of natures most gripping feats of survival is now better understood. For the first time, Berkeley Lab scientists observed the chemical changes in individual cells that enable them to survive in conditions that should kill them. http://newscenter.lbl.gov/feature-stories/2009/07/07/cells-endure-extremes/

  5. Auditory Temporal Conditioning in Neonates.

    ERIC Educational Resources Information Center

    Franz, W. K.; And Others

    Twenty normal newborns, approximately 36 hours old, were tested using an auditory temporal conditioning paradigm which consisted of a slow rise, 75 db tone played for five seconds every 25 seconds, ten times. Responses to the tones were measured by instantaneous, beat-to-beat heartrate; and the test trial was designated as the 2 1/2-second period…

  6. Condition Number Regularized Covariance Estimation*

    PubMed Central

    Won, Joong-Ho; Lim, Johan; Kim, Seung-Jean; Rajaratnam, Bala

    2012-01-01

    Estimation of high-dimensional covariance matrices is known to be a difficult problem, has many applications, and is of current interest to the larger statistics community. In many applications including so-called the “large p small n” setting, the estimate of the covariance matrix is required to be not only invertible, but also well-conditioned. Although many regularization schemes attempt to do this, none of them address the ill-conditioning problem directly. In this paper, we propose a maximum likelihood approach, with the direct goal of obtaining a well-conditioned estimator. No sparsity assumption on either the covariance matrix or its inverse are are imposed, thus making our procedure more widely applicable. We demonstrate that the proposed regularization scheme is computationally efficient, yields a type of Steinian shrinkage estimator, and has a natural Bayesian interpretation. We investigate the theoretical properties of the regularized covariance estimator comprehensively, including its regularization path, and proceed to develop an approach that adaptively determines the level of regularization that is required. Finally, we demonstrate the performance of the regularized estimator in decision-theoretic comparisons and in the financial portfolio optimization setting. The proposed approach has desirable properties, and can serve as a competitive procedure, especially when the sample size is small and when a well-conditioned estimator is required. PMID:23730197

  7. Conditions for Developing Communicative Competence

    ERIC Educational Resources Information Center

    Zascerinska, Jelena

    2010-01-01

    Introduction. Individuals need communicative competence for personal fulfillment and development, active citizenship, social inclusion and employment. Materials and Methods. The meaning of the key concepts of "communicative competence" and "opportunities" is studied within the search for conditions to develop. Conclusion. The theoretical findings…

  8. NATIONAL COASTAL CONDITION REPORT II

    EPA Science Inventory

    The purpose of EPA's National Coastal Assessment (NCA) program is to estimate the status and trends of the condition of the nation's coastal resources on state, regional and national scales. During 1999-2003, 100% of the nation's estuarine waters were representatively sampled at ...

  9. NATIONAL COASTAL CONDITION REPORT IV

    EPA Science Inventory

    The National Coastal Condition Report IV (NCCR IV) is the fourth in a series of environmental assessments of U.S. coastal waters and the Great Lakes. The report includes assessments of all the nation’s estuaries in the contiguous 48 states and Puerto Rico, south-eastern Alaska, ...

  10. Lightning injuries during snowy conditions.

    PubMed

    Cherington, M; Breed, D W; Yarnell, P R; Smith, W E

    1998-12-01

    Skiers and other snow sports enthusiasts can become lightning casualties. Two such accidents are reported, one being fatal. There are fewer warning signals of impending lightning strikes in winter-like conditions. However, outdoor activists should be aware of at least two suspicious clues: the appearance of convective clouds, and the presence of graupel (snow pellets) during precipitation.

  11. Conditioned Reinforcement and Response Strength

    ERIC Educational Resources Information Center

    Shahan, Timothy A.

    2010-01-01

    Stimuli associated with primary reinforcers appear themselves to acquire the capacity to strengthen behavior. This paper reviews research on the strengthening effects of conditioned reinforcers within the context of contemporary quantitative choice theories and behavioral momentum theory. Based partially on the finding that variations in…

  12. Neural basis of conditional cooperation.

    PubMed

    Suzuki, Shinsuke; Niki, Kazuhisa; Fujisaki, Syoken; Akiyama, Eizo

    2011-06-01

    Cooperation among genetically unrelated individuals is a fundamental aspect of society, but it has been a longstanding puzzle in biological and social sciences. Recently, theoretical studies in biology and economics showed that conditional cooperation-cooperating only with those who have exhibited cooperative behavior-can spread over a society. Furthermore, experimental studies in psychology demonstrated that people are actually conditional cooperators. In this study, we used functional magnetic resonance imaging to investigate the neural system underlying conditional cooperation by scanning participants during interaction with cooperative, neutral and non-cooperative opponents in prisoner's dilemma games. The results showed that: (i) participants cooperated more frequently with both cooperative and neutral opponents than with non-cooperative opponents; and (ii) a brain area related to cognitive inhibition of pre-potent responses (right dorsolateral prefrontal cortex) showed greater activation, especially when participants confronted non-cooperative opponents. Consequently, we suggest that cognitive inhibition of the motivation to cooperate with non-cooperators drives the conditional behavior.

  13. Neural basis of conditional cooperation

    PubMed Central

    Niki, Kazuhisa; Fujisaki, Syoken; Akiyama, Eizo

    2011-01-01

    Cooperation among genetically unrelated individuals is a fundamental aspect of society, but it has been a longstanding puzzle in biological and social sciences. Recently, theoretical studies in biology and economics showed that conditional cooperation—cooperating only with those who have exhibited cooperative behavior—can spread over a society. Furthermore, experimental studies in psychology demonstrated that people are actually conditional cooperators. In this study, we used functional magnetic resonance imaging to investigate the neural system underlying conditional cooperation by scanning participants during interaction with cooperative, neutral and non-cooperative opponents in prisoner's dilemma games. The results showed that: (i) participants cooperated more frequently with both cooperative and neutral opponents than with non-cooperative opponents; and (ii) a brain area related to cognitive inhibition of pre-potent responses (right dorsolateral prefrontal cortex) showed greater activation, especially when participants confronted non-cooperative opponents. Consequently, we suggest that cognitive inhibition of the motivation to cooperate with non-cooperators drives the conditional behavior. PMID:20501484

  14. Covariant jump conditions in electromagnetism

    NASA Astrophysics Data System (ADS)

    Itin, Yakov

    2012-02-01

    A generally covariant four-dimensional representation of Maxwell's electrodynamics in a generic material medium can be achieved straightforwardly in the metric-free formulation of electromagnetism. In this setup, the electromagnetic phenomena are described by two tensor fields, which satisfy Maxwell's equations. A generic tensorial constitutive relation between these fields is an independent ingredient of the theory. By use of different constitutive relations (local and non-local, linear and non-linear, etc.), a wide area of applications can be covered. In the current paper, we present the jump conditions for the fields and for the energy-momentum tensor on an arbitrarily moving surface between two media. From the differential and integral Maxwell equations, we derive the covariant boundary conditions, which are independent of any metric and connection. These conditions include the covariantly defined surface current and are applicable to an arbitrarily moving smooth curved boundary surface. As an application of the presented jump formulas, we derive a Lorentzian type metric as a condition for existence of the wave front in isotropic media. This result holds for ordinary materials as well as for metamaterials with negative material constants.

  15. Computer Developments in Air Conditioning.

    ERIC Educational Resources Information Center

    Pancoast, Ferendino, Grafton and Skeels, Architects, Miami, FL.

    Proceedings of a conference on the present and future uses of computer techniques in the air conditioning field. The recommendation of this report is, for the most part, negative insofar as it applies to the use of computers for design by the small office. However, there should be an awareness of their usefulness in controlling the environmental…

  16. Solitons induced by boundary conditions

    SciTech Connect

    Zhou, R.L.

    1987-01-01

    Although soliton phenomena have attracted wide attention since 1965, there are still not enough efforts paid to mixed-boundary - initial-value problems that are important in real physical cases. The main purpose of this thesis is to study carefully the various boundary-induced soliton under different initial conditions. The author states with three sets of nonlinear equations: KdV equations and Boussinesq equations (for water); two-fluid equations for cold-ion plasma. He was interested in four types of problems involved with water solitons: excitation by different time-dependent boundary conditions under different initial conditions; head-on and over-taking collisions; reflection at a wall and the excitation by pure initial conditions. For KdV equations, only cases one and four are conducted. The results from two fully nonlinear KdV and Boussinesq equations are compared, and agree extremely well. The Boussinesq equations permit solition head-on collisions and reflections, studied the first time. The results from take-over collision agree with KdV results. For the ion-acoustic plasma, a set of Boussinesq-type equations was derived from the standard two-fluid equations for the ion-acoustic plasma. It theoretically proves the essential nature of the solitary wave solutions of the cold-ion plasma. The ion acoustic solitons are also obtained by prescribing a potential phi/sub 0/ at one grid point.

  17. Conditions of Democracy: Elementary Perspectives

    ERIC Educational Resources Information Center

    LeCompte, Karon N.

    2006-01-01

    Exposure to ideas helps young children articulate their own beliefs and sharpens their connections. Teachers can provide opportunities for children to advance their knowledge about democratic conditions through sustained discourse, or, as described in this article, purposeful class discussions followed by hands-on activities. The author describes…

  18. Conditioned suppression, punishment, and aversion

    NASA Technical Reports Server (NTRS)

    Orme-Johnson, D. W.; Yarczower, M.

    1974-01-01

    The aversive action of visual stimuli was studied in two groups of pigeons which received response-contingent or noncontingent electric shocks in cages with translucent response keys. Presentation of grain for 3 sec, contingent on key pecking, was the visual stimulus associated with conditioned punishment or suppression. The responses of the pigeons in three different experiments are compared.

  19. Admission Conditions and Graduates' Employability

    ERIC Educational Resources Information Center

    Alexandre, Fernando; Portela, Miguel; Sa, Carla

    2009-01-01

    In a context of increasing competition for students, admission conditions have been used as an instrument in a strategy of differentiation. Such a strategy is guided by short-run concerns, that is, the immediate need to attract more students. This article takes a longer term view, by examining graduates' employability. The authors find that…

  20. Selective Influence through Conditional Independence.

    ERIC Educational Resources Information Center

    Dzhafarov, Ehtibar N.

    2003-01-01

    Presents a generalization and improvement for the definition proposed by E. Dzhafarov (2001) for selectiveness in the dependence of several random variables on several (sets of) external factors. This generalization links the notion of selective influence with that of conditional independence. (SLD)

  1. Condition assessment of nonlinear processes

    DOEpatents

    Hively, Lee M.; Gailey, Paul C.; Protopopescu, Vladimir A.

    2002-01-01

    There is presented a reliable technique for measuring condition change in nonlinear data such as brain waves. The nonlinear data is filtered and discretized into windowed data sets. The system dynamics within each data set is represented by a sequence of connected phase-space points, and for each data set a distribution function is derived. New metrics are introduced that evaluate the distance between distribution functions. The metrics are properly renormalized to provide robust and sensitive relative measures of condition change. As an example, these measures can be used on EEG data, to provide timely discrimination between normal, preseizure, seizure, and post-seizure states in epileptic patients. Apparatus utilizing hardware or software to perform the method and provide an indicative output is also disclosed.

  2. Habituation, sensitization, and Pavlovian conditioning

    PubMed Central

    Çevik, Münire Özlem

    2014-01-01

    In this brief review, I argue that the impact of a stimulus on behavioral control increase as the distance of the stimulus to the body decreases. Habituation, i.e., decrement in response intensity repetition of the triggering stimulus, is the default state for sensory processing, and the likelihood of habituation is higher for distal stimuli. Sensitization, i.e., increment in response intensity upon stimulus repetition, occurs in a state dependent manner for proximal stimuli that make direct contact with the body. In Pavlovian conditioning paradigms, the unconditioned stimulus (US) is always a more proximal stimulus than the conditioned stimulus (CS). The mechanisms of associative and non-associative learning are not independent. CS−US pairings lead to formation of associations if sensitizing modulation from a proximal US prevents the habituation for a distal anticipatory CS. PMID:24574983

  3. Habituation, sensitization, and Pavlovian conditioning.

    PubMed

    Cevik, Münire Özlem

    2014-01-01

    In this brief review, I argue that the impact of a stimulus on behavioral control increase as the distance of the stimulus to the body decreases. Habituation, i.e., decrement in response intensity repetition of the triggering stimulus, is the default state for sensory processing, and the likelihood of habituation is higher for distal stimuli. Sensitization, i.e., increment in response intensity upon stimulus repetition, occurs in a state dependent manner for proximal stimuli that make direct contact with the body. In Pavlovian conditioning paradigms, the unconditioned stimulus (US) is always a more proximal stimulus than the conditioned stimulus (CS). The mechanisms of associative and non-associative learning are not independent. CS-US pairings lead to formation of associations if sensitizing modulation from a proximal US prevents the habituation for a distal anticipatory CS. PMID:24574983

  4. Energy conditions in modified gravity

    NASA Astrophysics Data System (ADS)

    Capozziello, Salvatore; Lobo, Francisco S. N.; Mimoso, José P.

    2014-03-01

    We consider generalized energy conditions in modified theories of gravity by taking into account the further degrees of freedom related to scalar fields and curvature invariants. The latter are usually recast as generalized geometrical fluids that have different meanings with respect to the standard matter fluids generally adopted as sources of the field equations. More specifically, in modified gravity the curvature terms are grouped in a tensor H and a coupling g(Ψi) that can be reorganized in effective Einstein field equations, as corrections to the energy-momentum tensor of matter. The formal validity of such inequalities does not assure some basic requirements such as the attractive nature of gravity, so that the energy conditions have to be considered in a wider sense.

  5. CAIS. Condition Assessment Information System

    SciTech Connect

    Oak, J.C.

    1996-09-30

    CAIS is used by Architects and Engineers to gather facility condition assessment data. This data consist of architectural, civil, structural, electrical, and mechanical systems and components that are a part of the inspected facility. Data is collected using a hand-held, pen-based computer system which is preprogrammed for detailed inventories of individual components. The program is deficiency based for collecting data for repair and replacement observations. Observations are recorded on checklists preformatted to individual site needs, allowing for comments on unusual conditions to be documented on site. Data is transferred to a central database, where it can be reviewed, costed, and reported on using different scenarios. Information can be transferred to the DOE operations offices as well as to the DOE FIMS database for each site.

  6. DICE: Disk Initial Conditions Environment

    NASA Astrophysics Data System (ADS)

    Perret, Valentin

    2016-07-01

    DICE models initial conditions of idealized galaxies to study their secular evolution or their more complex interactions such as mergers or compact groups using N-Body/hydro codes. The code can set up a large number of components modeling distinct parts of the galaxy, and creates 3D distributions of particles using a N-try MCMC algorithm which does not require a prior knowledge of the distribution function. The gravitational potential is then computed on a multi-level Cartesian mesh by solving the Poisson equation in the Fourier space. Finally, the dynamical equilibrium of each component is computed by integrating the Jeans equations for each particles. Several galaxies can be generated in a row and be placed on Keplerian orbits to model interactions. DICE writes the initial conditions in the Gadget1 or Gadget2 (ascl:0003.001) format and is fully compatible with Ramses (ascl:1011.007).

  7. Hydrodynamics from Landau initial conditions

    SciTech Connect

    Sen, Abhisek; Gerhard, Jochen; Torrieri, Giorgio; Read jr, Kenneth F.; Wong, Cheuk-Yin

    2015-01-01

    We investigate ideal hydrodynamic evolution, with Landau initial conditions, both in a semi-analytical 1+1D approach and in a numerical code incorporating event-by-event variation with many events and transverse density inhomogeneities. The object of the calculation is to test how fast would a Landau initial condition transition to a commonly used boost-invariant expansion. We show that the transition to boost-invariant flow occurs too late for realistic setups, with corrections of O (20 - 30%) expected at freezeout for most scenarios. Moreover, the deviation from boost-invariance is correlated with both transverse flow and elliptic flow, with the more highly transversely flowing regions also showing the most violation of boost invariance. Therefore, if longitudinal flow is not fully developed at the early stages of heavy ion collisions, 2+1 dimensional hydrodynamics is inadequate to extract transport coefficients of the quark-gluon plasma. Based on [1, 2

  8. Phototherapy for sclerosing skin conditions.

    PubMed

    Teske, Noelle M; Jacobe, Heidi T

    2016-01-01

    Phototherapy is an effective treatment strategy for a variety of sclerosing skin conditions. There are a number of phototherapeutic modalities used for the treatment of sclerosing skin conditions, including ultraviolet (UV)A1, broadband UVA, psoralen plus UVA, and narrowband UVB phototherapy. As controlled trials with validated outcome measures are lacking for these therapies, existing evidence is largely level II for morphea and is even more minimal for scleroderma and other sclerosing disorders (scleroderma, lichen sclerosus, and chronic graft-versus-host disease, among others). Studies do suggest that phototherapy may be effective for many of these disorders, including those that have been unresponsive to other therapies. Phototherapy remains an attractive therapeutic option for patients due to its efficacy and favorable risk-versus-benefit profile. Phototherapy also offers a therapeutic alternative to systemic immunosuppressives for patients who cannot tolerate these medications. PMID:27638441

  9. Burden of major musculoskeletal conditions.

    PubMed Central

    Woolf, Anthony D.; Pfleger, Bruce

    2003-01-01

    Musculoskeletal conditions are a major burden on individuals, health systems, and social care systems, with indirect costs being predominant. This burden has been recognized by the United Nations and WHO, by endorsing the Bone and Joint Decade 2000-2010. This paper describes the burden of four major musculoskeletal conditions: osteoarthritis, rheumatoid arthritis, osteoporosis, and low back pain. Osteoarthritis, which is characterized by loss of joint cartilage that leads to pain and loss of function primarily in the knees and hips, affects 9.6% of men and 18% of women aged > 60 years. Increases in life expectancy and ageing populations are expected to make osteoarthritis the fourth leading cause of disability by the year 2020. Joint replacement surgery, where available, provides effective relief. Rheumatoid arthritis is an inflammatory condition that usually affects multiple joints. It affects 0.3-1.0% of the general population and is more prevalent among women and in developed countries. Persistent inflammation leads to joint destruction, but the disease can be controlled with drugs. The incidence may be on the decline, but the increase in the number of older people in some regions makes it difficult to estimate future prevalence. Osteoporosis, which is characterized by low bone mass and microarchitectural deterioration, is a major risk factor for fractures of the hip, vertebrae, and distal forearm. Hip fracture is the most detrimental fracture, being associated with 20% mortality and 50% permanent loss in function. Low back pain is the most prevalent of musculoskeletal conditions; it affects nearly everyone at some point in time and about 4-33% of the population at any given point. Cultural factors greatly influence the prevalence and prognosis of low back pain. PMID:14710506

  10. Analytical methods under emergency conditions

    SciTech Connect

    Sedlet, J.

    1983-01-01

    This lecture discusses methods for the radiochemical determination of internal contamination of the body under emergency conditions, here defined as a situation in which results on internal radioactive contamination are needed quickly. The purpose of speed is to determine the necessity for medical treatment to increase the natural elimination rate. Analytical methods discussed include whole-body counting, organ counting, wound monitoring, and excreta analysis. 12 references. (ACR)

  11. Monitoring Thermal Conditions in Footwear

    NASA Astrophysics Data System (ADS)

    Silva-Moreno, Alejandra. A.; Lopez Vela, Martín; Alcalá Ochoa, Noe

    2006-09-01

    Thermal conditions inside the foot were evaluated on a volunteer subject. We have designed and constructed an electronic system which can monitors temperature and humidity of the foot inside the shoe. The data is stored in a battery-powered device for later uploading to a host computer for data analysis. The apparatus potentially can be used to provide feedback to patients who are prone to having skin breakdowns.

  12. Bacteria under simulated Martian conditions.

    PubMed

    Young, R S; Deal, P H; Bell, J; Allen, J L

    1964-01-01

    The behavior of organisms in simulated Martian conditions is of great importance to exobiology for two reasons: (1) Because of the extreme environment of Mars, the likelihood of contamination of the planet by earth organisms is considered slight by some scientists. To date, there has been little evidence to contradict this supposition. Such evidence is presented. (2) The selection and adaptation of earth bacteria to Martian conditions is potentially significant in understanding Martian life, if it exists, and may be helpful in designing life-detection techniques and devices. Of course, simulation attempts, based on current knowledge of the Mars environment, may be far from the actual conditions, and extrapolations made from such situations of no real significance. However, generalizations can be made and cautious interpretation of the results of those experiments seems well worth reporting. A new technique for simulation of known parameters of the Martian environment is discussed along with possible biological implications. The response of bacteria to such simulation is demonstrated in terms of survival and growth, showing that certain bacteria will not only survive, but grow during simulated Martian freeze-thaw cycling if water is present. Ways are demonstrated in which water can be present on Mars although not detectable with current technology. Plans for future experimentation are discussed.

  13. Conditioned inhibition and reinforcement rate.

    PubMed

    Harris, Justin A; Kwok, Dorothy W S; Andrew, Benjamin J

    2014-07-01

    We investigated conditioned inhibition in a magazine approach paradigm. Rats were trained on a feature negative discrimination between an auditory conditioned stimulus (CS) reinforced at one rate versus a compound of that CS and a visual stimulus (L) reinforced at a lower rate. This training established L as a conditioned inhibitor. We then tested the inhibitory strength of L by presenting it in compound with other auditory CSs. L reduced responding when tested with a CS that had been reinforced at a high rate, but had less or even no inhibitory effect when tested with a CS that had been reinforced at a low rate. The inhibitory strength of L was greater if it signaled a decrease in reinforcement from an already low rate than if it signaled an equivalent decrease in reinforcement from a high rate. We conclude that the strength of inhibition is not a linear function of the change in reinforcement that it signals. We discuss the implications of this finding for models of learning (e.g., Rescorla & Wagner, 1972) that identify inhibition with a difference (subtraction) rule.

  14. UV photobiochemistry under space conditions

    NASA Astrophysics Data System (ADS)

    Dose, K.; Bieger-Dose, A.; Dillmann, R.; Gill, M.; Kerz, O.; Klein, A.; Stridde, C.

    The response of spores of Bacillus subtilis, cells of Deinococcus radiodurans and conidia of Aspergillus ochraceus to actual and simulated space conditions (UV in combination with long-term exposure to extremely dry conditions, including vacuum) has been studied: The following effects have been analyzed: decrease of viability, occurrence of DNA double strand breaks, formation of DNA-protein cross-links and DNA-DNA cross-links. All organisms show an increased sensitivity to UV light in extreme dryness (dry argon or vacuum) compared to an irradiation in aqueous suspension. The UV irradiation leads in all cases to a variety of DNA lesions. Very conspicuous is the occurrence of double strand breaks. Most of these double strand breaks are produced by incomplete repair of other lesions, especially base damages. The increase in DNA lesions can be correlated to the loss in viability. The specific response of the chromosomal DNA to UV irradiation in extreme dryness, however, varies from species to species and depends on the state of dehydration. The formation of DNA double strand breaks and DNA-protein cross-links prevails in the case of B. subtilis spores. In cells of Deinococcus radiodurans DNA-DNA cross-links often predominate, in conidia of Aspergillus ochraceus double strand breaks. The results obtained by direct exposure to space conditions (EURECA mission and D2 mission) largely agree with the laboratory data.

  15. Conditioned fear modulates visual selection.

    PubMed

    Mulckhuyse, Manon; Crombez, Geert; Van der Stigchel, Stefan

    2013-06-01

    Eye movements reflect the dynamic interplay between top-down- and bottom-up-driven processes. For example, when we voluntarily move our eyes across the visual field, salient visual stimuli in the environment may capture our attention, our eyes, or modulate the trajectory of an eye movement. Previous research has shown that the behavioral relevance of a salient stimulus modulates these processes. This study investigated whether a stimulus signaling an aversive event modulates saccadic behavior. Using a differential fear-conditioning procedure, we presented a threatening (conditional stimulus: CS+) and a nonthreatening stimulus distractor (CS-) during an oculomotor selection task. The results show that short-latency saccades deviated more strongly toward the CS+ than toward the CS- distractor, whereas long-latency saccades deviated more strongly away from the CS+ than from the CS- distractor. Moreover, the CS+ distractor captured the eyes more often than the CS- distractor. Together, these results demonstrate that conditioned fear has a direct and immediate influence on visual selection. The findings are interpreted in terms of a neurobiological model of emotional visual processing. PMID:23356561

  16. Reconstruction of FXR Beam Conditions

    SciTech Connect

    Nexen, W E; Scarpetti, R D; Zentler, J

    2001-05-31

    Beam-envelope radius, envelope angle, and beam emittance can be derived from measurements of beam radius for at least three different transport conditions. We have used this technique to reconstruct exit parameters from the FXR injector and accelerator. We use a diamagnetic loop (DML) to measure the magnetic moment of the high current beam. With no assumptions about radial profile, we can derive the beam mean squire radius from the moment under certain easily met conditions. Since it is this parameter which is required for the reconstruction, it is evident that the DML is the ideal diagnostic for this technique. The simplest application of this technique requires at least three shots for a reconstruction but in reality requires averaging over many more shots because of shot to shot variation. Since DML measurements do not interfere with the beam, single shot time resolved measurements of the beam parameters appear feasible if one uses an array of at least three DMLs separated by known transport conditions.

  17. [Mathematical modeling for conditionality of cardiovascular disease by housing conditions].

    PubMed

    Meshkov, N A

    2014-01-01

    There was studied the influence of living conditions (housing area per capita, availability of housing water supply, sewerage and central heating) on the morbidity of the cardiovascular diseases in child and adult population. With the method of regression analysis the morbidity rate was established to significantly decrease with the increase in the area of housing, constructed models are statistically significant, respectively, p = 0.01 and p = 0.02. There was revealed the relationship of the morbidity rate of cardiovascular diseases in children and adults with the supply with housing central heating (p = 0.02 and p = 0.009). PMID:25950060

  18. Conditions for successful data assimilation

    NASA Astrophysics Data System (ADS)

    Morzfeld, M.; Chorin, A. J.

    2013-12-01

    Many applications in science and engineering require that the predictions of uncertain models be updated by information from a stream of noisy data. The model and the data jointly define a conditional probability density function (pdf), which contains all the information one has about the process of interest and various numerical methods can be used to study and approximate this pdf, e.g. the Kalman filter, variational methods or particle filters. Given a model and data, each of these algorithms will produce a result. We are interested in the conditions under which this result is reasonable, i.e. consistent with the real-life situation one is modeling. In particular, we show, using idealized models, that numerical data assimilation is feasible in principle only if a suitably defined effective dimension of the problem is not excessive. This effective dimension depends on the noise in the model and the data, and in physically reasonable problems it can be moderate even when the number of variables is huge. In particular, we find that the effective dimension being moderate induces a balance condition between the noises in the model and the data; this balance condition is often satisfied in realistic applications or else the noise levels are excessive and drown the underlying signal. We also study the effects of the effective dimension on particle filters in two instances, one in which the importance function is based on the model alone, and one in which it is based on both the model and the data. We have three main conclusions: (1) the stability (i.e., non-collapse of weights) in particle filtering depends on the effective dimension of the problem. Particle filters can work well if the effective dimension is moderate even if the true dimension is large (which we expect to happen often in practice). (2) A suitable choice of importance function is essential, or else particle filtering fails even when data assimilation is feasible in principle with a sequential algorithm

  19. PCB biohalogenation under anaerobic conditions

    SciTech Connect

    Gauger, W.K.; McCue, J.J.

    1990-01-01

    The Institute of Gas Technology (IGT) is conducting research on the biodehalogenation of polychlorinated biphenyls (PCB's) under anoxic conditions. Reductive dechlorination of PCB's has been observed in treatments inoculated with Hudson River sediments. Differences in gas chromatograms between time 0 and 4-month incubations indicate pattern shifts of the PCB homologs that constitute Aroclor 1242 from highly chlorinated to lesser chlorinated congeners. Changes in distribution patterns of PCB homologs were also evident. PCB homologs containing 4, 5, 6, and 7 chlorine atoms were shown to decrease over the incubation period, whereas PCB homologs containing 2 and 3 chlorines increased in concentration. 10 refs., 5 figs., 1 tab.

  20. Conditional unitary transformation on biphotons

    SciTech Connect

    Brida, G.; Genovese, M.; Gramegna, M.; Chekhova, M.V.; Krivitsky, L.A.; Kulik, S.P.

    2004-09-01

    A conditional unitary transformation (90 deg. polarization rotation) is performed at single-photon level. The transformation is realized by rotating polarization for one of the photons of a polarization-entangled biphoton state (signal photon) by means of a Pockel cell triggered by the detection of the other (idler) photon after polarization selection. As a result, the state of the signal photon is losslessly changed from being completely unpolarized to being partially polarized, so that the final polarization degree is given by the idler detector quantum efficiency. This experiment can be used for developing a different method of absolute quantum efficiency calibration.

  1. Ionic homeostasis in brain conditioning

    PubMed Central

    Cuomo, Ornella; Vinciguerra, Antonio; Cerullo, Pierpaolo; Anzilotti, Serenella; Brancaccio, Paola; Bilo, Leonilda; Scorziello, Antonella; Molinaro, Pasquale; Di Renzo, Gianfranco; Pignataro, Giuseppe

    2015-01-01

    Most of the current focus on developing neuroprotective therapies is aimed at preventing neuronal death. However, these approaches have not been successful despite many years of clinical trials mainly because the numerous side effects observed in humans and absent in animals used at preclinical level. Recently, the research in this field aims to overcome this problem by developing strategies which induce, mimic, or boost endogenous protective responses and thus do not interfere with physiological neurotransmission. Preconditioning is a protective strategy in which a subliminal stimulus is applied before a subsequent harmful stimulus, thus inducing a state of tolerance in which the injury inflicted by the challenge is mitigated. Tolerance may be observed in ischemia, seizure, and infection. Since it requires protein synthesis, it confers delayed and temporary neuroprotection, taking hours to develop, with a pick at 1–3 days. A new promising approach for neuroprotection derives from post-conditioning, in which neuroprotection is achieved by a modified reperfusion subsequent to a prolonged ischemic episode. Many pathways have been proposed as plausible mechanisms to explain the neuroprotection offered by preconditioning and post-conditioning. Although the mechanisms through which these two endogenous protective strategies exert their effects are not yet fully understood, recent evidence highlights that the maintenance of ionic homeostasis plays a key role in propagating these neuroprotective phenomena. The present article will review the role of protein transporters and ionic channels involved in the control of ionic homeostasis in the neuroprotective effect of ischemic preconditioning and post-conditioning in adult brain, with particular regards to the Na+/Ca2+ exchangers (NCX), the plasma membrane Ca2+-ATPase (PMCA), the Na+/H+ exchange (NHE), the Na+/K+/2Cl− cotransport (NKCC) and the acid-sensing cation channels (ASIC). Ischemic stroke is the third leading

  2. Conditional sign flip via teleportation

    SciTech Connect

    Giorgi, Gian Luca; Pasquale, Ferdinando de; Paganelli, Simone

    2004-08-01

    We present a model to realize a probabilistic conditional sign flip gate using only linear optics. The gate operates in the space of number-state qubits and is obtained by a nonconventional use of the teleportation protocol. Both a destructive and a nondestructive version of the gate are presented. In the former case an Hadamard gate on the control qubit is combined with a projective teleportation scheme mixing control and target. The success probability is 1/2. In the latter case we need a quantum encoder realized via the interaction of the control qubit with an ancillary state composed of two maximally entangled photons. The success probability is 1/4.

  3. Initial conditions for vector inflation

    SciTech Connect

    Chiba, Takeshi

    2008-08-15

    Recently, a model of inflation using non-minimally coupled massive vector fields has been proposed. For a particular choice of non-minimal coupling parameter and for a flat Friedmann-Robertson-Walker model, the model is reduced to the model of chaotic inflation with massive scalar field. We study the effect of non-zero curvature of the universe on the onset of vector inflation. We find that in a curved universe the dynamics of vector inflation can be different from the dynamics of chaotic inflation, and the fraction of the initial conditions leading to inflationary solutions is reduced as compared with the chaotic inflation case.

  4. Mean Flow Boundary Conditions for Computational Aeroacoustics

    NASA Technical Reports Server (NTRS)

    Hixon, R.; Nallasamy, M.; Sawyer, S.; Dyson, R.

    2003-01-01

    In this work, a new type of boundary condition for time-accurate Computational Aeroacoustics solvers is described. This boundary condition is designed to complement the existing nonreflective boundary conditions while ensuring that the correct mean flow conditions are maintained throughout the flow calculation. Results are shown for a loaded 2D cascade, started with various initial conditions.

  5. A Ranking-Theoretic Approach to Conditionals

    ERIC Educational Resources Information Center

    Spohn, Wolfgang

    2013-01-01

    Conditionals somehow express conditional beliefs. However, conditional belief is a bi-propositional attitude that is generally not truth-evaluable, in contrast to unconditional belief. Therefore, this article opts for an expressivistic semantics for conditionals, grounds this semantics in the arguably most adequate account of conditional belief,…

  6. Evaluative Conditioning: The "How" Question.

    PubMed

    Jones, Christopher R; Olson, Michael A; Fazio, Russell H

    2010-01-01

    Evaluative conditioning (EC) refers to attitude formation or change toward an object due to that object's mere co-occurrence with another valenced object or objects. This chapter focuses on the "how" question, that is, the question of what cognitive processes intervene between mere co-occurrence and attitude formation or change. Though EC has typically been thought of as occurring through a single, albeit contentious, mechanism, we begin by pointing out that both the heterogeneity of EC methodologies and the abundance of inconsistent results suggest that multiple processes with different characteristics can produce EC. We describe how the earliest posited process of EC, Pavlovian conditioning or signal learning, is a valid mechanism of EC that appears to have operated in some experiments but is unlikely to have operated in others and also cannot account for various EC findings. We describe other mechanisms of EC, when they can be expected to occur, and what characteristics they have. We particularly focus our attention on a process model of EC we have recently introduced, the implicit misattribution model. Finally, we describe the implications of a multi-process view of EC, which we argue can help resolve theoretical controversies and further the application of EC as a practical intervention for influencing attitudes in various domains.

  7. The dynamics of operant conditioning.

    PubMed

    Dragoi, V; Staddon, J E

    1999-01-01

    Existing models of operant learning are relatively insensitive to historical properties of behavior and applicable to only limited data sets. This article proposes a minimal set of principles based on short-term and long-term memory mechanisms that can explain the major static and dynamic properties of operant behavior in both single-choice and multiresponse situations. The critical features of the theory are as follows: (a) The key property of conditioning is assessment of the degree of association between responses and reinforcement and between stimuli and reinforcement; (b) the contingent reinforcement is represented by learning expectancy, which is the combined prediction of response-reinforcement and stimulus-reinforcement associations; (c) the operant response is controlled by the interplay between facilitatory and suppressive variables that integrate differences between expected (long-term) and experienced (short-term) events; and (d) very-long-term effects are encoded by a consolidated memory that is sensitive to the entire reinforcement history. The model predicts the major qualitative features of operant phenomena and then suggests an experimental test of theoretical predictions about the joint effects of reinforcement probability and amount of training on operant choice. We hypothesize that the set of elementary principles that we propose may help resolve the long-standing debate about the fundamental variables controlling operant conditioning.

  8. Diamond nucleation under bias conditions

    SciTech Connect

    Stoeckel, R.; Stammler, M.; Janischowsky, K.; Ley, L.; Albrecht, M.; Strunk, H.P.

    1998-01-01

    The so-called bias pretreatment allows the growth of heteroepitaxial diamond films by plasma chemical vapor deposition on silicon (100) surfaces. We present plan-view and cross-sectional transmission electron micrographs of the substrate surface at different phases of the bias pretreatment. These observations are augmented by measurements of the etch rates of Si, SiC, and different carbon modifications under plasma conditions and the size distribution of oriented diamond crystals grown after bias pretreatment. Based on these results a new model for diamond nucleation under bias conditions is proposed. First, a closed layer of nearly epitaxially oriented cubic SiC with a thickness of about 10 nm is formed. Subplantation of carbon into this SiC layer causes a supersaturation with carbon and results in the subcutaneous formation of epitaxially oriented nucleation centers in the SiC layer. Etching of the SiC during the bias pretreatment as well as during diamond growth brings these nucleation centers to the sample surface and causes the growth of diamonds epitaxially oriented on the Si/SiC substrate. {copyright} {ital 1998 American Institute of Physics.}

  9. Eruption conditions of spatter deposits

    NASA Astrophysics Data System (ADS)

    Rader, Erika; Geist, Dennis

    2015-10-01

    Spatter is an eruptive product that forms within a narrow range of thermal conditions: it must be hot enough to deform and agglutinate, but not so hot that clasts completely re-fuse and remobilize as clastogenic lava. This narrow thermal window of spatter-forming conditions allows for quantitative prediction of cooling rates and accumulation rates. Cooling and accumulation rates then provide information that enables estimates of eruption parameters for inaccessible and prehistoric deposits. High-temperature experiments conducted on basaltic scoria from Devil's Garden, Oregon have revealed the eruption temperature was ~ 1130 °C. The strength welds formed between experimental clasts is shown to depend on cooling rate. Natural samples are compared to the experimental samples by measuring tensile strength and welded area between clasts. The weld strength in natural deposits yields estimates of cooling rates that range between 2.5 °C and 48 °C/min, with the majority of the samples grouping between 7 °C and 14 °C/min. Thermal models based on these cooling rates yield spatter accumulation rates of 0.5-1.8 m/h in the Devil's Garden spatter deposits. We provide a general model for cooling and accumulation rates for spatter cones, ramparts, and hornitos, which allow estimation of the factors that control basaltic eruptive products.

  10. Urogynecologic conditions: pelvic organ prolapse.

    PubMed

    Noor, Nabila; Garely, Alan D

    2015-03-01

    Chronic pelvic pain is a commonly encountered condition that often is multifactorial. Etiologies include gynecologic, urologic, gastrointestinal, and neurologic conditions. Laboratory tests, imaging, and surgical intervention are not always helpful in identifying the etiology of pelvic pain. For appropriate management of this complex disease process, a detailed history and physical examination, and a multidisciplinary approach are needed. Pelvic pain may be caused by endometriosis, pelvic inflammatory disease, adenomyosis, interstitial cystitis/painful bladder syndrome, or other factors. Evaluation may include keeping a pain diary; laboratory tests, such as a pregnancy test, urinalysis, or tests for sexually transmitted infections; ultrasonography of abnormalities detected on physical examination; and laparoscopy. Specific first-line treatments include nonsteroidal anti-inflammatory drugs and oral contraceptives for endometriosis; progestins, gonadotropin-releasing hormone analogs, aromatase inhibitors, or hysterectomy for adenomyosis; and education, food avoidance, and behavioral modifications for interstitial cystitis/painful bladder syndrome. Surgical options include nerve transection procedures, laparoscopic uterosacral nerve ablation, and presacral neurectomy, although data on effectiveness are limited. PMID:25756374

  11. Bone Remodeling Under Pathological Conditions.

    PubMed

    Xiao, Wenmei; Li, Shuai; Pacios, Sandra; Wang, Yu; Graves, Dana T

    2016-01-01

    Bone is masterfully programmed to repair itself through the coupling of bone formation following bone resorption, a process referred to as coupling. In inflammatory or other conditions, the balance between bone resorption and bone formation shifts so that a net bone loss results. This review focuses on four pathologic conditions in which remodeling leads to net loss of bone, postmenopausal osteoporosis, arthritis, periodontal disease, and disuse bone loss, which is similar to bone loss associated with microgravity. In most of these there is an acceleration of the resorptive process due to increased formation of bone metabolic units. This initially leads to a net bone loss since the time period of resorption is much faster than the time needed for bone formation that follows. In addition, each of these processes is characterized by an uncoupling that leads to net bone loss. Mechanisms responsible for increased rates of bone resorption, i.e. the formation of more bone metabolic units, involve enhanced expression of inflammatory cytokines and increased expression of RANKL. Moreover, the reasons for uncoupling are discussed which range from a decrease in expression of growth factors and bone morphogenetic proteins to increased expression of factors that inhibit Wnt signaling. PMID:26599114

  12. Melting processes under microgravity conditions

    NASA Astrophysics Data System (ADS)

    Glicksman, M.; Lupulescu, A.; Koss, M.

    The Rensselaer Isothermal Dendritic Growth Experiment (RIDGE) uses the large data archive amassed through a series of three NASA-supported microgravity experiments (IDGE/USMP-2, -3, and -4), all of which flew aboard the space shuttle Columbia. The IDGE instruments aboard USMP-2 and -3 provided in-flight CCD images, and 35-mm films (postflight). USMP-4 also allowed streaming of near-real-time video. Using 30 fps video data, it became possible for the first time to study both freezing and melting sequences for high-purity pivalic acid (PVA). We report on the melting process observed for PVA crystal fragments, observed under nearly ideal convection-free conditions. Conduction-limited melting processes are of importance in orbital melting of materials, meteoritic genesis, mushy-zone evolution, and in fusion weld pools where length scales for thermal buoyancy are restricted. Microgravity video show clearly that PVA dendrites melt into fragments that shrink at accelerating rates to extinction. The melting paths of individual fragments follow characteristic time dependences derived from theory. The theoretical melting kinetics against which the experimental observations are carefully compared is based on conduction-limited quasi-static melting under shape-preserving conditions. Good agreement between theory and experiment is found for the stable melting of needle-shaped prolate spheroidal PVA crystal fragments with aspect ratios near C /A = 12.

  13. How Are Genetic Conditions Treated or Managed?

    MedlinePlus

    ... are genetic conditions treated or managed? How are genetic conditions treated or managed? Many genetic disorders result ... out more about the treatment and management of genetic conditions: Links to information about the treatment of ...

  14. Boundary Condition for Modeling Semiconductor Nanostructures

    NASA Technical Reports Server (NTRS)

    Lee, Seungwon; Oyafuso, Fabiano; von Allmen, Paul; Klimeck, Gerhard

    2006-01-01

    A recently proposed boundary condition for atomistic computational modeling of semiconductor nanostructures (particularly, quantum dots) is an improved alternative to two prior such boundary conditions. As explained, this boundary condition helps to reduce the amount of computation while maintaining accuracy.

  15. Physical conditions in molecular clouds

    NASA Technical Reports Server (NTRS)

    Evans, Neal J., II

    1989-01-01

    Recent developments have complicated the picture of the physical conditions in molecular clouds. The discoveries of widespread emission from high-J lines of CD and 12-micron IRAS emission have revealed the presence of considerably hotter gas and dust near the surfaces of molecular clouds. These components can complicate interpretation of the bulk of the cloud gas. Commonly assumed relations between column density or mean density and cloud size are called into question by conflicting results and by consideration of selection effects. Analysis of density and density structure through molecular excitation has shown that very high densities exist in star formation regions, but unresolved structure and possible chemical effects complicate the interpretation. High resolution far-IR and submillimeter observations offer a complementary approach and are beginning to test theoretical predictions of density gradients in clouds.

  16. Azerbaijan: environmental conditions and outlook.

    PubMed

    Shelton, Napier

    2003-06-01

    The author describes present environmental conditions in Azerbaijan in relation to the Soviet legacy and measures taken since independence. Environmental projects have been financed largely by international organizations and foreign companies. The most serious problems are contaminants in the Caspian Sea; air, water, and soil pollution in Sumgait; illegal fishing; poor quality of drinking water; cutting of forests for fuel and pasture; overgrazing; and soil erosion and salinization. Progress in developing an environmental conscience, necessary for sustained protection of the environment, will depend most importantly on environmental education, growth of democratic institutions and attitudes that encourage both governmental and citizen responsibility for the environment, and economic development that produces a substantial middle class. Positive advances include a Constitution and laws that require protection of the environment, and individuals who speak out for environmental care. Negative factors include poverty and the present government's low priority for environmental protection. PMID:12956597

  17. Shapiro step at nonequilibrium conditions

    NASA Astrophysics Data System (ADS)

    Shukrinov, Yu. M.; Nashaat, M.; Kulikov, K. V.; Dawood, R.; El Samman, H.; El Sherbini, Th. M.

    2016-07-01

    Detailed numerical simulations of intrinsic Josephson junctions of high-temperature superconductors under external electromagnetic radiation are performed taking into account a charge imbalance effect. We demonstrate that the charge imbalance is responsible for a slope in the Shapiro step in the IV-characteristic. The value of slope increases with a nonequilibrium parameter. Coupling between junctions leads to the distribution of the slope's values along the stack. The nonperiodic boundary conditions shift the Shapiro step from the canonical position determined by Vss=\\hbar f /(2e) , where f is a frequency of external radiation. This fact makes the interpretation of the experimentally found Shapiro step shift by the charge imbalance effect ambiguous.

  18. Terrestrial accretion under oxidizing conditions.

    PubMed

    Siebert, Julien; Badro, James; Antonangeli, Daniele; Ryerson, Frederick J

    2013-03-01

    The abundance of siderophile elements in the mantle preserves the signature of core formation. On the basis of partitioning experiments at high pressure (35 to 74 gigapascals) and high temperature (3100 to 4400 kelvin), we demonstrate that depletions of slightly siderophile elements (vanadium and chromium), as well as moderately siderophile elements (nickel and cobalt), can be produced by core formation under more oxidizing conditions than previously proposed. Enhanced solubility of oxygen in the metal perturbs the metal-silicate partitioning of vanadium and chromium, precluding extrapolation of previous results. We propose that Earth accreted from materials as oxidized as ordinary or carbonaceous chondrites. Transfer of oxygen from the mantle to the core provides a mechanism to reduce the initial magma ocean redox state to that of the present-day mantle, reconciling the observed mantle vanadium and chromium concentrations with geophysical constraints on light elements in the core. PMID:23306436

  19. Venous conditions associated with pregnancy.

    PubMed

    Skudder, P A; Farrington, D T

    1993-06-01

    Pregnancy is associated with several changes in venous physiology. These include relaxation of venous wall tone and increased lower extremity venous pressure. As a result of these changes, varicose veins, spider telangiectasias, purpura, and other superficial findings may develop. Treatment of these conditions is conservative during pregnancy. As the changes in venous hemodynamics resolve over several weeks after delivery, partial or complete regression may occur. In cases where persistent abnormality persists well after delivery, more definitive therapy may be considered. Pregnancy is also associated with a mild hypercoagulable state, and there may be trauma to venous endothelium associated with delivery. Coupled with the relative stasis resulting from pelvic venous compression by the uterus and from decreases in venous tone, these changes cause an increased risk of deep vein thrombosis in late pregnancy and the peripartum period. Anticoagulation with heparin is required as coumadin and fibrinolytic agents are considered to be hazardous.

  20. Centaur Propellant Thermal Conditioning Study

    NASA Technical Reports Server (NTRS)

    Blatt, M. H.; Pleasant, R. L.; Erickson, R. C.

    1976-01-01

    A wicking investigation revealed that passive thermal conditioning was feasible and provided considerable weight advantage over active systems using throttled vent fluid in a Centaur D-1s launch vehicle. Experimental wicking correlations were obtained using empirical revisions to the analytical flow model. Thermal subcoolers were evaluated parametrically as a function of tank pressure and NPSP. Results showed that the RL10 category I engine was the best candidate for boost pump replacement and the option showing the lowest weight penalty employed passively cooled acquisition devices, thermal subcoolers, dry ducts between burns and pumping of subcooler coolant back into the tank. A mixing correlation was identified for sizing the thermodynamic vent system mixer. Worst case mixing requirements were determined by surveying Centaur D-1T, D-1S, IUS, and space tug vehicles. Vent system sizing was based upon worst case requirements. Thermodynamic vent system/mixer weights were determined for each vehicle.

  1. Raman spectroscopy under extreme conditions

    SciTech Connect

    Goncharov, A F; Crowhurst, J C

    2004-11-05

    We report the results of Raman measurements of various materials under simultaneous conditions of high temperature and high pressure in the diamond anvil cell (DAC). High temperatures are generated by laser heating or internal resistive (ohmic) heating or a combination of both. We present Raman spectra of cubic boron nitride (cBN) to 40 GPa and up to 2300 K that show a continuous pressure and temperature shift of the frequency of the transverse optical mode. We have also obtained high-pressure Raman spectra from a new noble metal nitride, which we synthesized at approximately 50 GPa and 2000 K. We have obtained high-temperature spectra from pure nitrogen to 39 GPa and up to 2000 K, which show the presence of a hot band that has previously been observed in CARS measurements. These measurements have also allowed us to constrain the melting curve and to examine changes in the intramolecular potential with pressure.

  2. Uncertain deduction and conditional reasoning

    PubMed Central

    Evans, Jonathan St. B. T.; Thompson, Valerie A.; Over, David E.

    2015-01-01

    There has been a paradigm shift in the psychology of deductive reasoning. Many researchers no longer think it is appropriate to ask people to assume premises and decide what necessarily follows, with the results evaluated by binary extensional logic. Most every day and scientific inference is made from more or less confidently held beliefs and not assumptions, and the relevant normative standard is Bayesian probability theory. We argue that the study of “uncertain deduction” should directly ask people to assign probabilities to both premises and conclusions, and report an experiment using this method. We assess this reasoning by two Bayesian metrics: probabilistic validity and coherence according to probability theory. On both measures, participants perform above chance in conditional reasoning, but they do much better when statements are grouped as inferences, rather than evaluated in separate tasks. PMID:25904888

  3. Azerbaijan: environmental conditions and outlook.

    PubMed

    Shelton, Napier

    2003-06-01

    The author describes present environmental conditions in Azerbaijan in relation to the Soviet legacy and measures taken since independence. Environmental projects have been financed largely by international organizations and foreign companies. The most serious problems are contaminants in the Caspian Sea; air, water, and soil pollution in Sumgait; illegal fishing; poor quality of drinking water; cutting of forests for fuel and pasture; overgrazing; and soil erosion and salinization. Progress in developing an environmental conscience, necessary for sustained protection of the environment, will depend most importantly on environmental education, growth of democratic institutions and attitudes that encourage both governmental and citizen responsibility for the environment, and economic development that produces a substantial middle class. Positive advances include a Constitution and laws that require protection of the environment, and individuals who speak out for environmental care. Negative factors include poverty and the present government's low priority for environmental protection.

  4. Carbon tetrachloride under extreme conditions

    SciTech Connect

    Pravica, Michael Sneed, Daniel; Wang, Yonggang; Smith, Quinlan; Subrahmanyam, Garimella

    2014-05-21

    We report on three experiments on carbon tetrachloride subjected to extreme conditions. In the first experiment, Raman spectra of CCl{sub 4} were acquired up to 28 GPa. Evidence was observed for at least two new phases of CCl{sub 4} above 14 GPa (phase VI) and above 22 GPa (phase VII). Decompression of the sample showed no evidence of pressure-induced decomposition. In the second experiment, a synchrotron x-ray diffraction study was performed up to 30 GPa verifying phase V and potential phases above 14 (VI) and 22 GPa (VII), respectively. In the third study, we examined irradiated CCl{sub 4} using synchrotron infrared spectroscopy to reduce fluorescent contamination. Some sort of carbon allotrope appears as a byproduct suggesting the following reaction with hard x-rays: CCl{sub 4}+ hν → C + 2Cl{sub 2}.

  5. Optimising Extinction of Conditioned Disgust

    PubMed Central

    Bosman, Renske C.; Borg, Charmaine; de Jong, Peter J.

    2016-01-01

    Maladaptive disgust responses are tenacious and resistant to exposure-based interventions. In a similar vein, laboratory studies have shown that conditioned disgust is relatively insensitive to Conditioned Stimulus (CS)-only extinction procedures. The relatively strong resistance to extinction might be explained by disgust’s adaptive function to motivate avoidance from contamination threats (pathogens) that cannot be readily detected and are invisible to the naked eye. Therefore, the mere visual presentation of unreinforced disgust eliciting stimuli might not be sufficient to correct a previously acquired threat value of the CS+. Following this, the current study tested whether the efficacy of CS-only exposure can be improved by providing additional safety information about the CS+. For the CSs we included two neutral items a pea soup and a sausage roll, whereas for the Unconditioned Stimulus (US) we used one video clip of a woman vomiting and a neutral one about glass blowing. The additional safety information was conveyed by allowing actual contact with the CS+ or by observing an actress eating the food items representing the CS+. When additional safety information was provided via allowing direct contact with the CS+, there was a relatively strong post-extinction increase in participants’ willingness-to-eat the CS+. This beneficial effect was still evident at one-week follow up. Also self-reported disgust was lower at one-week follow up when additional safety information was provided. The current findings help explain why disgust is relatively insensitive to CS-only extinction procedures, and provide helpful starting points to improve interventions that are aimed to reduce distress in disgust-related psychopathology. PMID:26849211

  6. Redox conditions for mantle plumes

    NASA Astrophysics Data System (ADS)

    Heister, L. E.; Lesher, C. E.

    2005-12-01

    The vanadium to scandium ratio (V/Sc) for basalts from mid-ocean ridge (MOR) and arc environments has been proposed as a proxy for fO2 conditions during partial melting (e.g. [1] and [2]). Contrary to barometric measurements of the fO2 of primitive lavas, the V/Sc ratio of the upper mantle at mid-ocean ridges and arcs is similar, leading previous authors to propose that the upper mantle has uniform redox potential and is well-buffered. We have attempted to broaden the applicability of the V/Sc parameter to plume-influenced localities (both oceanic and continental), where mantle heterogeneities associated with recycled sediments, mafic crust, and metasomatized mantle, whether of shallow or deep origin, exist. We find that primitive basalts from the North Atlantic Igneous Province (NAIP), Hawaii (both the Loa and Kea trends), Deccan, Columbia River, and Siberian Traps show a range of V/Sc ratios that are generally higher (average ~9) than those for MOR (average ~ 6.7) or arc (average ~7) lavas. Based on forward polybaric decompression modeling, we attribute these differences to polybaric melting and melt segregation within the garnet stability field rather than the presence of a more oxidized mantle in plume-influenced settings. Like MORB, the V/Sc ratios for plume-influenced basalts can be accounted for by an oxidation state approximately one log unit below the Ni-NiO buffer (NNO-1). Our analysis suggests that source heterogeneities have little, if any, resolvable influence on mantle redox conditions, although they have significant influence on the trace element and isotopic composition of mantle-derived melts. We suggest that variations in the redox of erupted lavas is largely a function of shallow lithospheric processes rather than intrinsic to the mantle source, regardless of tectonic setting. [1] Li and Lee (2004) EPSL, [2] Lee et al. (2005) J. of Petrology

  7. Drug disposition in pathophysiological conditions.

    PubMed

    Gandhi, Adarsh; Moorthy, Bhagavatula; Ghose, Romi

    2012-11-01

    Expression and activity of several key drug metabolizing enzymes (DMEs) and transporters are altered in various pathophysiological conditions, leading to altered drug metabolism and disposition. This can have profound impact on the pharmacotherapy of widely used clinically relevant medications in terms of safety and efficacy by causing inter-individual variabilities in drug responses. This review article highlights altered drug disposition in inflammation and infectious diseases, and commonly encountered disorders such as cancer, obesity/diabetes, fatty liver diseases, cardiovascular diseases and rheumatoid arthritis. Many of the clinically relevant drugs have a narrow therapeutic index. Thus any changes in the disposition of these drugs may lead to reduced efficacy and increased toxicity. The implications of changes in DMEs and transporters on the pharmacokinetics/pharmacodynamics of clinically-relevant medications are also discussed. Inflammation-mediated release of pro-inflammatory cytokines and activation of toll-like receptors (TLRs) are known to play a major role in down-regulation of DMEs and transporters. Although the mechanism by which this occurs is unclear, several studies have shown that inflammation-associated cell-signaling pathway and its interaction with basal transcription factors and nuclear receptors in regulation of DMEs and transporters play a significant role in altered drug metabolism. Altered regulation of DMEs and transporters in a multitude of disease states will contribute towards future development of powerful in vitro and in vivo tools in predicting the drug response and opt for better drug design and development. The goal is to facilitate a better understanding of the mechanistic details underlying the regulation of DMEs and transporters in pathophysiological conditions. PMID:22746301

  8. Optimising Extinction of Conditioned Disgust.

    PubMed

    Bosman, Renske C; Borg, Charmaine; de Jong, Peter J

    2016-01-01

    Maladaptive disgust responses are tenacious and resistant to exposure-based interventions. In a similar vein, laboratory studies have shown that conditioned disgust is relatively insensitive to Conditioned Stimulus (CS)-only extinction procedures. The relatively strong resistance to extinction might be explained by disgust's adaptive function to motivate avoidance from contamination threats (pathogens) that cannot be readily detected and are invisible to the naked eye. Therefore, the mere visual presentation of unreinforced disgust eliciting stimuli might not be sufficient to correct a previously acquired threat value of the CS+. Following this, the current study tested whether the efficacy of CS-only exposure can be improved by providing additional safety information about the CS+. For the CSs we included two neutral items a pea soup and a sausage roll, whereas for the Unconditioned Stimulus (US) we used one video clip of a woman vomiting and a neutral one about glass blowing. The additional safety information was conveyed by allowing actual contact with the CS+ or by observing an actress eating the food items representing the CS+. When additional safety information was provided via allowing direct contact with the CS+, there was a relatively strong post-extinction increase in participants' willingness-to-eat the CS+. This beneficial effect was still evident at one-week follow up. Also self-reported disgust was lower at one-week follow up when additional safety information was provided. The current findings help explain why disgust is relatively insensitive to CS-only extinction procedures, and provide helpful starting points to improve interventions that are aimed to reduce distress in disgust-related psychopathology. PMID:26849211

  9. PFBC freeboard firing under part load conditions development of a CFD based design tool

    SciTech Connect

    Edens, T.; Werther, J.; Hartge, E.U.; Jansson, S.A.; Bergqvist, S.

    1999-07-01

    ABB is currently building a second generation Pressurized Fluidized Bed Combined-Cycle (PFBC) plant in Cottbus, Germany. It will generate heat and electricity for the city of Cottbus, burning locally mined brown coal. In this plant, which is based on ABB's P200 PFBC module, a freeboard firing system operated with light oil will for the first time ever be used to maintain a high inlet temperature to the GT35P machine also at part load. This promotes oxidation of CO and makes selective non-catalytic NO{sub x} reduction effective also in this load range. In the present work a modeling tool is being developed in support of the design of the freeboard firing system and to help evaluate the performance of this system during operation. Another purpose of this tool is to check the sensitivity of the temperature distribution in the freeboard against a maldistribution of the fuel. For these purposes a model based on the full set of mass, momentum and energy balances was established. A commercially available computational fluid dynamics (CFD) program package was used to implement and solve the model. For the solution a stepwise approach has been chosen: in a first step the penetration of the oil jet into the freeboard, its dispersion, gasification and combustion has been modeled for a single jet. For these calculations a locally very fine grid was used. In a second step the freeboard with multiple oil jets will be described. In this latter step it will be necessary to reduce the spatial resolution significantly due to the limitation of computational resources. In the present paper the approach will be described in detail and some first computational results concerning the combustion of an oil spray will be presented.

  10. Hot conditioning equipment conceptual design report

    SciTech Connect

    Bradshaw, F.W., Westinghouse Hanford

    1996-08-06

    This report documents the conceptual design of the Hot Conditioning System Equipment. The Hot conditioning System will consist of two separate designs: the Hot Conditioning System Equipment; and the Hot Conditioning System Annex. The Hot Conditioning System Equipment Design includes the equipment such as ovens, vacuum pumps, inert gas delivery systems, etc.necessary to condition spent nuclear fuel currently in storage in the K Basins of the Hanford Site. The Hot Conditioning System Annex consists of the facility of house the Hot Conditioning System. The Hot Conditioning System will be housed in an annex to the Canister Storage Building. The Hot Conditioning System will consist of pits in the floor which contain ovens in which the spent nuclear will be conditioned prior to interim storage.

  11. Conditional Generation of Monthly Precipitation

    NASA Astrophysics Data System (ADS)

    Kim, U.; Kaluarachchi, J. J.

    2006-12-01

    Monthly precipitation models can be used in basin-wide modeling to develop long-term strategies for water resources planning and management and to estimate the change of water yield due to climate change. Such precipitation models are especially important for effective management of river basins in developing countries such as the upper Blue Nile River basin of Ethiopia where the water resource utilization is limited. Many studies have been previously performed to preserve historical temporal and spatial structures when generating precipitation series. The main focus of those studies was to preserve the historical statistics. Other important factors to be considered are transition and spatial correlations. A few recent studies attempted to preserve transition as well as the statistics of historical record. These studies provided satisfactory results while showing the difficulty and complexity of computations in their methods. The conditional generation method (CGM) that can preserve both historical temporal and spatial structures is presented in this study. Because the CGM is driven from the historical conditional probabilities occurring given amounts of precipitation between two successive months or two stations, it is computationally simple and reliable, i.e., parameterization, inverse matrix, or optimum band width is not required. The CGM was applied to reproducing the precipitation pattern of the upper Blue Nile River basin in Ethiopia using monthly precipitation data of 10 stations to demonstrate its applicability. Comparing to the method of inverse transformation of cumulative distribution functions of the gamma distribution and nonparametric kernel estimator with variable band width selected from the goodness-of-fit tests, the CGM showed improved performance, especially in representing the transition characteristics. The CGM also generated the historical spatial correlations between the stations with acceptable accuracy. The results suggested that the CGM

  12. Alcoholism: A systemic proinflammatory condition

    PubMed Central

    González-Reimers, Emilio; Santolaria-Fernández, Francisco; Martín-González, María Candelaria; Fernández-Rodríguez, Camino María; Quintero-Platt, Geraldine

    2014-01-01

    Excessive ethanol consumption affects virtually any organ, both by indirect and direct mechanisms. Considerable research in the last two decades has widened the knowledge about the paramount importance of proinflammatory cytokines and oxidative damage in the pathogenesis of many of the systemic manifestations of alcoholism. These cytokines derive primarily from activated Kupffer cells exposed to Gram-negative intestinal bacteria, which reach the liver in supra-physiological amounts due to ethanol-mediated increased gut permeability. Reactive oxygen species (ROS) that enhance the inflammatory response are generated both by activation of Kupffer cells and by the direct metabolic effects of ethanol. The effects of this increased cytokine secretion and ROS generation lie far beyond liver damage. In addition to the classic consequences of endotoxemia associated with liver cirrhosis that were described several decades ago, important research in the last ten years has shown that cytokines may also induce damage in remote organs such as brain, bone, muscle, heart, lung, gonads, peripheral nerve, and pancreas. These effects are even seen in alcoholics without significant liver disease. Therefore, alcoholism can be viewed as an inflammatory condition, a concept which opens the possibility of using new therapeutic weapons to treat some of the complications of this devastating and frequent disease. In this review we examine some of the most outstanding consequences of the altered cytokine regulation that occurs in alcoholics in organs other than the liver. PMID:25356029

  13. Alcoholism: a systemic proinflammatory condition.

    PubMed

    González-Reimers, Emilio; Santolaria-Fernández, Francisco; Martín-González, María Candelaria; Fernández-Rodríguez, Camino María; Quintero-Platt, Geraldine

    2014-10-28

    Excessive ethanol consumption affects virtually any organ, both by indirect and direct mechanisms. Considerable research in the last two decades has widened the knowledge about the paramount importance of proinflammatory cytokines and oxidative damage in the pathogenesis of many of the systemic manifestations of alcoholism. These cytokines derive primarily from activated Kupffer cells exposed to Gram-negative intestinal bacteria, which reach the liver in supra-physiological amounts due to ethanol-mediated increased gut permeability. Reactive oxygen species (ROS) that enhance the inflammatory response are generated both by activation of Kupffer cells and by the direct metabolic effects of ethanol. The effects of this increased cytokine secretion and ROS generation lie far beyond liver damage. In addition to the classic consequences of endotoxemia associated with liver cirrhosis that were described several decades ago, important research in the last ten years has shown that cytokines may also induce damage in remote organs such as brain, bone, muscle, heart, lung, gonads, peripheral nerve, and pancreas. These effects are even seen in alcoholics without significant liver disease. Therefore, alcoholism can be viewed as an inflammatory condition, a concept which opens the possibility of using new therapeutic weapons to treat some of the complications of this devastating and frequent disease. In this review we examine some of the most outstanding consequences of the altered cytokine regulation that occurs in alcoholics in organs other than the liver.

  14. Respiratory Conditions Update: Cystic Fibrosis.

    PubMed

    Pritchard, Lyle L

    2016-09-01

    Cystic fibrosis (CF) is an autosomal recessive genetic disease that occurs in approximately 1 in 2,500 white live births. It is less common in nonwhite individuals. A dysfunctional epithelial chloride channel leads to excessively thick mucus affecting multiple organ systems. Common issues include mucous plugging of the airway, lung inflammation, chronic pulmonary infections, intestinal malabsorption, and malnutrition. Universal screening of newborns for CF is recommended in many countries. CF can be diagnosed based on clinical evidence of disease along with genetic testing or other laboratory evidence of chloride channel dysfunction. Pulmonary system dysfunction causes the most morbidity and mortality. Pulmonary function testing is the primary modality used to monitor CF progression. Therapies include chest physiotherapy, mucolytics, antibiotics, anti-inflammatory drugs, targeted therapies, and vaccines. Dysfunction of the exocrine pancreas and gastrointestinal tract leads to malabsorption, malnutrition, and intestinal obstruction. Nutrition should be optimized with adequate calories, pancreatic enzymes, and appropriate dietary supplements. Complications, including acute pulmonary exacerbations, gastrointestinal conditions, chronic rhinosinusitis, CF-related diabetes, osteoporosis, infertility, and psychosocial issues, must be managed. At the appropriate time, lung transplantation and end-of-life issues must be addressed. PMID:27576234

  15. Sleep behavior and unemployment conditions.

    PubMed

    Antillón, Marina; Lauderdale, Diane S; Mullahy, John

    2014-07-01

    Recent research has reported that habitually short sleep duration is a risk factor for declining health, including increased risk of obesity, diabetes and coronary heart disease. In this study we investigate whether macroeconomic conditions are associated with variation in mean sleep time in the United States, and if so, whether the effect is procyclical or countercyclical. We merge state unemployment rates from 2003 through 2012 with the American Time Use Survey, a nationally representative sample of adults with 24h time diaries. We find that higher aggregate unemployment is associated with longer mean sleep duration, with each additional point of state unemployment associated with an additional average 0.83 min of sleep (p<0.001), after adjusting for a secular trend of increasing sleep over the time period. Despite a national poll in 2009 that found one-third of Americans reporting losing sleep over the economy, we do not find that higher state unemployment is associated with more sleeplessness. Instead, we find that higher state unemployment is associated with less frequent time use described as "sleeplessness" (marginal effect=0.05 at 4% unemployment and 0.034 at 14% unemployment, p<0.001), after controlling for a secular trend.

  16. Boundary conditions of methamphetamine craving.

    PubMed

    Lopez, Richard B; Onyemekwu, Chukwudi; Hart, Carl L; Ochsner, Kevin N; Kober, Hedy

    2015-12-01

    Methamphetamine use has increased significantly and become a global health concern. Craving is known to predict methamphetamine use and relapse following abstinence. Some have suggested that cravings are automatic, generalized, and uncontrollable, but experimental work addressing these claims is lacking. In 2 exploratory studies, we tested the boundary conditions of methamphetamine craving by asking: (a) is craving specific to users' preferred route of administration?, and (b) can craving be regulated by cognitive strategies? Two groups of methamphetamine users were recruited. In Study 1, participants were grouped by their preferred route of administration (intranasal vs. smoking), and rated their craving in response to photographs and movies depicting methamphetamine use (via the intranasal vs. smoking route). In Study 2, methamphetamine smokers implemented cognitive regulation strategies while viewing photographs depicting methamphetamine smoking. Strategies involved either focusing on the positive aspects of smoking methamphetamine or the negative consequences of doing so-the latter strategy based on treatment protocols for addiction. In Study 1, we found a significant interaction between group and route of administration, such that participants who preferred to smoke methamphetamine reported significantly stronger craving for smoking stimuli, whereas those who preferred the intranasal route reported stronger craving for intranasal stimuli. In Study 2, participants reported significantly lower craving when focusing on the negative consequences associated with methamphetamine use. Taken together, these findings suggest that strength of craving for methamphetamine is moderated by users' route of administration and can be reduced by cognitive strategies. This has important theoretical, methodological, and clinical implications.

  17. Efficient robust conditional random fields.

    PubMed

    Song, Dongjin; Liu, Wei; Zhou, Tianyi; Tao, Dacheng; Meyer, David A

    2015-10-01

    Conditional random fields (CRFs) are a flexible yet powerful probabilistic approach and have shown advantages for popular applications in various areas, including text analysis, bioinformatics, and computer vision. Traditional CRF models, however, are incapable of selecting relevant features as well as suppressing noise from noisy original features. Moreover, conventional optimization methods often converge slowly in solving the training procedure of CRFs, and will degrade significantly for tasks with a large number of samples and features. In this paper, we propose robust CRFs (RCRFs) to simultaneously select relevant features. An optimal gradient method (OGM) is further designed to train RCRFs efficiently. Specifically, the proposed RCRFs employ the l1 norm of the model parameters to regularize the objective used by traditional CRFs, therefore enabling discovery of the relevant unary features and pairwise features of CRFs. In each iteration of OGM, the gradient direction is determined jointly by the current gradient together with the historical gradients, and the Lipschitz constant is leveraged to specify the proper step size. We show that an OGM can tackle the RCRF model training very efficiently, achieving the optimal convergence rate [Formula: see text] (where k is the number of iterations). This convergence rate is theoretically superior to the convergence rate O(1/k) of previous first-order optimization methods. Extensive experiments performed on three practical image segmentation tasks demonstrate the efficacy of OGM in training our proposed RCRFs.

  18. Medical and orthopedic conditions and sports participation.

    PubMed

    Diokno, Eugene; Rowe, Dale

    2010-06-01

    The presence of certain medical or orthopedic conditions need not preclude adolescents from being physically active and participating in sports. The benefits of continued physical activity far outweigh any concerns for potential complications for most such conditions. This article reviews sport participation guidelines for adolescents with conditions that include juvenile chronic arthritis, eye injures, solitary kidney, skin conditions, scoliosis, and spondylolysis.

  19. 14 CFR 23.349 - Rolling conditions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Rolling conditions. 23.349 Section 23.349... Rolling conditions. The wing and wing bracing must be designed for the following loading conditions: (a..., the rolling accelerations may be obtained by modifying the symmetrical flight conditions in §...

  20. The Role of Contingency in Classical Conditioning.

    ERIC Educational Resources Information Center

    Papini, Mauricio R.; Bitterman, M. E.

    1990-01-01

    Early experiments suggesting that classical conditioning depends on the contingency between conditioned stimulus (CS) and the unconditioned stimulus (US) are reconsidered along with later evidence that shows conditioning of the CS and its context in random training. CS-US contingency is neither necessary nor sufficient for conditioning. (SLD)