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Sample records for abbott park il

  1. 77 FR 75610 - Foreign-Trade Zone 22-Chicago, IL, Notification of Proposed Production Activity, Abbott...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-21

    ... Foreign-Trade Zones Board Foreign-Trade Zone 22--Chicago, IL, Notification of Proposed Production Activity, Abbott Laboratories, Inc., AbbVie, Inc. (Pharmaceutical Production), North Chicago, IL, Area Abbott... authority within Subzones 22F and 22S, at sites located in the North Chicago and Lake County, Illinois, area...

  2. Performance evaluation of a particle-enhanced turbidimetric cystatin C assay on the Abbott ci8200 analyzer.

    PubMed

    Flodin, Mats; Larsson, Anders

    2009-06-01

    Glomerular filtration rate (GFR) is widely accepted as the best overall measure of kidney function. Cystatin C is a novel endogenous GFR marker that has been shown to be superior to creatinine for estimation of GFR in several studies. There is a need for cystatin C assays adapted to routine chemistry instrument to minimize turnaround times and allowing 24 h/day availability. We have evaluated a new cystatin C assay developed for Architect cSystem (Abbott Laboratories, Abbott Park, IL, USA). The cystatin C assay showed good agreement with the corresponding assay from Dade Behring (Deerfield, IL, USA). The assay has a very low total imprecision and a good linearity. The new cystatin C assay is an interesting alternative to current cystatin C assays. On an Architect cSystem the assay can be performed with the same turnaround times and availability as creatinine.

  3. 42. Peaks of Otter, Abbott Lake. View across lake to ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    42. Peaks of Otter, Abbott Lake. View across lake to peaks of Outter Lodge, completed in 1964. Construction of the lake got underway in 1964. Looking east-northeast. - Blue Ridge Parkway, Between Shenandoah National Park & Great Smoky Mountains, Asheville, Buncombe County, NC

  4. Comparison of the AcT 5 diff autoloader hematology analyzer to the Abbott Cell-Dyn 3200 analyzer at Charlevoix Area Hospital.

    PubMed

    Rogers, Sherri

    2003-01-01

    The Coulter AcT 5 diff autoloader (AL) hematology analyzer (Beckman Coulter, Fullerton, CA, USA) was evaluated at the Charlevoix Area Hospital, a small rural community hospital. The analyzer was compared to the laboratory's current instrument, a Cell-Dyn 3200 (Abbott Laboratories, Abbott Park, IL, USA). The study included comparisons of precision, efficiency and productivity, and reliability. The 5-part white blood cell differentials on both instruments were compared, and the clinical utility and flagging performance of both analyzers were confirmed by manual differential counts. The AcT 5 diff AL was shown to have excellent precision and accuracy. The addition of the autoloader to the AcT 5 diff provides a low-volume system with the added benefits of a "load and leave" analyzer normally available only to larger laboratories.

  5. An illness in the family: Dr. Maude Abbott and her sister, Alice Abbott.

    PubMed

    Brookes, Barbara

    2011-01-01

    This paper explores Maude Abbott's internationally significant career in medicine and her parallel commitment to caring for her sister, Alice Abbott. An examination of Abbott's life reveals the difficulties faced by an ambitious Canadian woman in medicine from the 1890s to the 1920s; difficulties compounded by caring for a sister with a mental illness. The Abbott archive suggests that it was far more difficult for a woman doctor to make the kind of sharp distinction between public and private life that might be expected of professional men.

  6. Nystatin LF (Aronex/Abbott).

    PubMed

    Arikan, S; Rex, J H

    2001-04-01

    November 1998, Aronex signed a licensing collaboration with Abbott Laboratories for the worldwide rights to nystatin LF [305531].

  7. Rapid virological response assessment by Abbott RealTime hepatitis C virus assay for predicting sustained virological responses in patients with hepatitis C virus genotype 1 treated with pegylated-interferon and ribavirin.

    PubMed

    Su, Pei-Yuan; Yen, Hsu-Heng; Hsu, Yu-Chun; Wu, Shun-Sheng; Kor, Chew-Teng; Su, Wei-Wen

    2016-07-01

    The lower limits of virus detection of hepatitis C virus (HCV) RNA detection assays are continuously improving. We aimed to assess the utility of more precise definition of 4(th) week viral load [rapid virological response (RVR)] in predicting sustained virological response (SVR) in HCV genotype 1 patients treated with pegylated-interferon (PEG-IFN) and ribavirin. Clinical data of treatment-naïve HCV genotype 1 patients were retrospectively collected from 2009 to 2014. Patients were grouped according to 4(th) week viral load as follows: undetectable (n = 90) and detectable but not quantifiable (< 12 IU/mL, n = 27). All patients received PEG-IFNα-2a or -2b and ribavirin for 24 weeks. Serum HCV RNA levels were measured by Abbott RealTime (ART; Abbott Molecular, Abbott Park, IL, USA) HCV assay. SVR was 95.5% and 63% in the undetectable group and < 12 IU/mL group of 4(th) week viral load, respectively. The between-group difference in SVR was significant (p < 0.001). We determined 4(th) week viral load was independently associated with SVR (odds ratio = 19.28; p = 0.002) and a good predictor of SVR [area under the curve (AUC) = 0.775; p = 0.001]. ART HCV assays had a stronger SVR predictive value in HCV genotype 1 patients, indicating that only the undetectable group of 4(th) week viral load patients measured by ART HCV assay should be considered for shorter treatment time (24 weeks) with PEG-IFN and ribavirin.

  8. Relationship between cyclosporine concentrations obtained using the Roche Cobas Integra and Abbott TDx monoclonal immunoassays in pre-dose and two hour post-dose blood samples from kidney transplant recipients.

    PubMed

    Garrido, Manuel J; Hermida, Jesús; Tutor, J Carlos

    2002-12-01

    Current evidence suggests that cyclosporine (CsA) concentration in blood samples taken 2 hours after Neoral microemulsion (Novartis Pharmaceuticals; East Hanover, NJ) administration (C2) predicts clinical events in transplant patients better than the pre-dose (trough) concentration (C0). Similarly, previous findings have shown that the metabolites/CsA ratio is substantially lower in C2 than in C0 samples; however the between-monoclonal immunoassay differences for C2 samples have received little attention in the literature. In 56 C samples and 60 C samples from renal transplant patients, CsA levels were determined using the monoclonal fluorescence polarization immunoassay (mFPIA) from Abbott (Abbott Park, IL) and the homogeneous enzyme immunoassay technique (HEIT) from Roche Diagnostics (Basel, Switzerland). In both cases a high correlation coefficient between the results was obtained (r > or = 0.971), with a linear regression for C0 samples: mFPIA = 1.47 HEIT + 22.0 and for C2 samples: mFPIA = 1.11 HEIT + 71.96. The difference between the linear regression slopes was statistically significant (P < 0.001), and the mFPIA/HEIT ratio was significantly higher for C than for C samples (P < 0.001).

  9. Product development: the making of the Abbott ARCHITECT.

    PubMed

    Kisner, H J

    1997-01-01

    Many laboratorians have a limited perspective on what is involved in developing an instrument and bringing it to market. This article traces the product development process used by Abbott Diagnostics Division that resulted in Abbott being named the 1996 Concurrent Engineering Company of the Year for the design of the ARCHITECT.

  10. 77 FR 13232 - Abbott Laboratories; Filing of Food Additive Petition

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-06

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 172 Abbott Laboratories; Filing of Food Additive Petition AGENCY: Food and Drug Administration, HHS. ACTION: Notice of petition. SUMMARY: The Food and Drug Administration (FDA) is announcing that Abbott Laboratories has filed a petition proposing that the food additive...

  11. The paediatric cardiology Hall of Fame: Maude Elizabeth Abbott.

    PubMed

    Evans, William N; Béland, Marie J

    2010-04-01

    Few paediatric cardiologists know of Maude Abbott. Yet before Helen Taussig, no one contributed more to founding the specialty than Maude Abbott. She achieved international fame as the early 20th century expert on cardiac malformations. We summarise here her life and contributions, indicating how she is more than justified in being inducted to the Hall of Fame.

  12. Evaluation of the Abbott HBV RUO sequencing assay combined with laboratory-modified interpretive software.

    PubMed

    Germer, Jeffrey J; Abraham, Priya; Mandrekar, Jayawant N; Yao, Joseph D C

    2013-01-01

    The Abbott HBV RUO Sequencing assay (Abbott Molecular Inc., Des Plaines, IL), which combines automated sample processing, real-time PCR, and bidirectional DNA sequencing, was evaluated for detection of nucleos(t)ide analogue (NA) resistance-associated mutations located in the hepatitis B virus (HBV) polymerase (Pol) gene. Interpretive software from the assay manufacturer was modified to allow interrogation of the overlapping HBV surface (S) gene sequence for HBV genotype determination and detection of immune escape mutations. Analytical sensitivity (detection and sequencing) of the assay was determined to be 103.9 IU/ml (95% confidence interval [CI], 80.0 to 173.3) for HBV genotype A. Testing of commercially available HBV genotype panels consisting of 23 individual members yielded complete agreement between expected results and results obtained from the laboratory-developed HBV genotype library. Excellent specificity was observed among clinical specimens with serologic or molecular markers for various unrelated blood-borne viruses (n = 6) and sera obtained from healthy, HBV-negative blood donors (n = 20). Retrospectively selected clinical specimens tested by a commercial reference laboratory HBV sequencing assay (n = 54) or the Trugene HBV Genotyping kit (n = 7) and the Abbott HBV RUO Sequencing assay showed minor differences in detection and reporting of NA resistance-associated mutations in 7 of 61 (11.5%) specimens but complete agreement of genotype results. The Abbott HBV RUO Sequencing assay provided a convenient and efficient assay workflow suitable for routine clinical laboratory use, with the flexibility to be modified for customized detection of NA resistance-associated mutations, HBV genotype determination, and detection of immune escape mutations from a single contiguous HBV sequence.

  13. 78 FR 77771 - PennantPark SBIC Il, LP; Notice Seeking Exemption Under Section 312 of the Small Business...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-24

    ... Investment Act, Conflicts of Interest Notice is hereby given that PennantPark SBIC II, LP, 1590 Madison... exemption under Section 312 of the Act and Section 107.730, Financings which Constitute Conflicts of...

  14. Maude E Abbott - physician and scientist of international fame.

    PubMed

    Ferencz, C

    2000-07-01

    Dr Maude E Abbott (1869 to 1940) is the only Canadian and the only woman represented in Diego Rivera's great mural of the History of Cardiology in Mexico City. She gained this place among the world's famous physicians and scientists by her outstanding studies of congenital heart disease. Her atlas of 1000 cases with clinical, pathological and morphological findings is the first systematic study of these anomalies. Dr Abbott developed a pathophysiological classification of cardiovascular defects fundamental for the development of cardiac surgery. She also considered prevention by prenatal care, recognizing possible genetic and environmental risk factors. Maude Abbott was a thoughtful clinician and a brilliant scientist of incomparable industry. She leaves an unfinished legacy to make the prevention of congenital heart disease a reality.

  15. 76 FR 4283 - Foreign-Trade Zone 153-San Diego, CA; Application for Manufacturing Authority; Abbott...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-25

    ...; Abbott Cardiovascular Systems, Inc. (Cardiovascular Device Manufacturing); Riverside County, CA An... of FTZ 153, requesting manufacturing authority on behalf of Abbott Cardiovascular Systems, Inc... production of cardiovascular devices including stents, catheters and guidewires. Components and materials...

  16. The Abbott Districts in 2005-06: Progress and Challenges, Spring 2006

    ERIC Educational Resources Information Center

    Hirsch, Lesley

    2006-01-01

    New Jersey's urban--or "Abbott"--schools have improved at the preschool and elementary school level, but lag when it comes to middle and high school performance. These are the key findings of an Abbott Indicators Project report entitled, "The Abbott Districts in 2005-06: Progress and Challenges." The report was prepared by…

  17. Women in History--Grace Abbott: A Leader in Social Reform

    ERIC Educational Resources Information Center

    Hoffman, Shari Cole

    2006-01-01

    This article profiles Grace Abbott, one of the earlier 20th century American women leaders in Progressivism. Abbott's heritage influenced her lifetime commitment to social improvement. She was born on November 17, 1878 in Grand Island, Nebraska into a family of activists. Her Quaker mother, Elizabeth Griffin Abbott, came from an abolitionist…

  18. Women in History--Grace Abbott: A Leader in Social Reform

    ERIC Educational Resources Information Center

    Hoffman, Shari Cole

    2006-01-01

    This article profiles Grace Abbott, one of the earlier 20th century American women leaders in Progressivism. Abbott's heritage influenced her lifetime commitment to social improvement. She was born on November 17, 1878 in Grand Island, Nebraska into a family of activists. Her Quaker mother, Elizabeth Griffin Abbott, came from an abolitionist…

  19. Integrating Students of Limited English Proficiency into Standards-Based Reform in the Abbott Districts. Abbott Implementation Resource Guide

    ERIC Educational Resources Information Center

    Lucas, Tamara; Villegas, Ana Maria

    2004-01-01

    In 1999-2000, over one-third of all students in the 30 Abbott districts spoke a native language other than English, and more than one-tenth were considered limited English proficient (LEP). The proportions of LEP students varied considerably across the districts, but they comprised between 5% and 29% of total enrollments in 18 of the districts.…

  20. Avoidance of generic competition by Abbott Laboratories' fenofibrate franchise.

    PubMed

    Downing, Nicholas S; Ross, Joseph S; Jackevicius, Cynthia A; Krumholz, Harlan M

    2012-05-14

    The ongoing debate concerning the efficacy of fenofibrate has overshadowed an important aspect of the drug's history: Abbott Laboratories, the maker of branded fenofibrate, has produced several bioequivalent reformulations that dominate the market, although generic fenofibrate has been available for almost a decade. This continued use of branded formulations, which cost twice as much as generic versions of fenofibrate, imposes an annual cost of approximately $700 million on the US health care system. Abbott Laboratories maintained its dominance of the fenofibrate market in part through a complex switching strategy involving the sequential launch of branded reformulations that had not been shown to be superior to the first-generation product and patent litigation that delayed the approval of generic formulations. The small differences in dose of the newer branded formulations prevented their substitution with generics of older-generation products. As soon as direct generic competition seemed likely at the new dose level, where substitution would be allowed, Abbott would launch another reformulation, and the cycle would repeat. Based on the fenofibrate example, our objective is to describe how current policy can allow pharmaceutical companies to maintain market share using reformulations of branded medications, without demonstrating the superiority of next-generation products.

  1. The Abbott Preschool Program: Fifth Year Report on Enrollment and Budget

    ERIC Educational Resources Information Center

    Applewhite, Erain; Hirsch, Lesley

    2003-01-01

    The New Jersey Supreme Court's 1998 ruling in Abbott v. Burke represents the first judicial directive in the nation that public education must include a high-quality, well-planned preschool program starting at age three. This decision applies to 30 urban school districts, known as the Abbott districts, that serve approximately 25 percent of the…

  2. 76 FR 47143 - Approval for Manufacturing Authority, Foreign-Trade Zone 153; Abbott Cardiovascular Systems, Inc...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-04

    ... Cardiovascular Systems, Inc., (Cardiovascular Devices), Riverside County, CA Pursuant to its Authority Under the... 153, has requested manufacturing authority on behalf of Abbott Cardiovascular Systems, Inc., within... procedures at sites within FTZ 153, on behalf of Abbott Cardiovascular Systems, Inc., as described in the...

  3. Abbott Preschool Program Longitudinal Effects Study: Fifth Grade Follow-Up

    ERIC Educational Resources Information Center

    Barnett, W. Steven; Jung, Kwanghee; Youn, Min-Jong; Frede, Ellen C.

    2013-01-01

    New Jersey's Abbott Preschool program is of broad national and international interest because the Abbott program provides a model for building a high-quality system of universal pre-K through public-private partnerships that transform the existing system. The program offers high-quality pre-K to all children in 31 New Jersey communities with high…

  4. Abbott Preschool Program Longitudinal Effects Study: Fifth Grade Follow-Up

    ERIC Educational Resources Information Center

    Barnett, W. Steven; Jung, Kwanghee; Youn, Min-Jong; Frede, Ellen C.

    2013-01-01

    New Jersey's Abbott Preschool program is of broad national and international interest because the Abbott program provides a model for building a high-quality system of universal pre-K through public-private partnerships that transform the existing system. The program offers high-quality pre-K to all children in 31 New Jersey communities with high…

  5. A checklist of the vascular plants in Abbott Creek Research Natural Area, Oregon.

    Treesearch

    Rod. Mitchell

    1979-01-01

    This paper is a checklist of 277 vascular plant taxa that have been collected or encountered in Abbott Creek Research Natural Area, Oregon; a brief description of five forested and two nonforested vegetation types is included.

  6. The relationship between Maude Abbott and Helen Taussig: connecting the historical dots.

    PubMed

    Evans, William N

    2008-12-01

    The literature has scant documentation of the relationship between the important founders of paediatric cardiology, Maude Abbott and Helen Taussig. Recently discovered entries in the diaries kept by Maude Abbott provide evidence for a close connection between them. Further evidence suggests that their association was complex, and influenced by outside factors, such as their difference in age and era-related notoriety. In this review, I attempt to define more clearly the relationship between these two early icons of paediatric cardiology.

  7. European multicentre evaluation of the ABBOTT Spectrum clinical chemistry analyzer.

    PubMed

    Blijenberg, B G; Braconnier, F; Vallez, J M; Burlina, A; Plebani, M; Celadin, M; Haeckel, R; Römer, M; Hänseler, E; De Schrijver, G

    1989-06-01

    The analytical performance of the selective multitest ABBOTT Spectrum analyser was studied according to the ECCLS guidelines and partly the CERMAB protocol in a multicentre evaluation involving laboratories from six European countries. Fifteen analytes, including the electrolytes sodium, potassium and chloride, were measured each in at least 3 laboratories, all at 37 degrees C, except the electrolytes, which are measured at room temperature. The trial lasted approximately three months and involved the collection of over 60,000 data points. It yielded the following results: 1. The precision was at least as good as the precision obtained with the comparison instruments. The majority of the coefficients of variation were between 1 and 4%. 2. The recovery for method assigned control sera values was, with few exceptions, within 10%. 3. Good agreement with respect to the method assigned values of control materials and method comparison with patient specimens to different instruments (e.g. SMAC, Hitachi 737, RA 1000) was found. 4. No drift was observed. 5. Reagent-related carry-over was not found. Specimen-related carry-over was detected in some cases, the deviation being of little or no clinical significance. 6. The manufacturer's claims regarding method linearity were as stated or exceeded. 7. The open system capability was tested and rated as very convenient. 8. The practicability of the instrument was very good.

  8. William Osler, Maude Abbott, Paul Dudley White, and Helen Taussig: the origins of congenital heart disease in North America.

    PubMed

    Wooley, Charles F; Miller, Pamela J

    2008-01-01

    In 1965, Helen Taussig traced the evolution of knowledge of congenital heart disease (CHD) during the 20th century, beginning with the William Osler-Maude Abbott lineage at McGill University in Montreal, Canada. Osler encouraged Abbott in her CHD pathologic observations. Abbott's London Exhibit (1934) preceded her classic text Atlas of Congenital Cardiac Disease (1936). Taussig's friendship with Abbott (1935) began in Boston; Abbott brought Taussig to meet Paul Dudley White whose text Heart Disease (1931) featured Abbott's work. Taussig visited Abbott (Montreal 1938). Abbott's statistical approach was based on post-mortem malformations; Taussig's concern was why CHD babies died. Abbott (1927) suggested surgery for a patent ductus arteriosus; Taussig conceived of creating a patent ductus arteriosus shunt to improve lung blood flow in cyanotic "blue babies". Surgeon Alfred Blalock and Taussig collaborated with the blue baby shunt operations (1944-1945), opening the field of cardiac surgery in cyanotic babies. Taussig's Congenital Malformations of the Heart text came 2 years later. Sequential contributions by Osler, Abbott, White, and Taussig were landmarks in the evolution of knowledge of CHD in North America.

  9. Partnering for Preschool: A Study of Center Directors in New Jersey's Mixed-Delivery Abbott Program. Research Report

    ERIC Educational Resources Information Center

    Whitebook, Marcy; Ryan, Sharon; Kipnis, Fran; Sakai, Laura

    2008-01-01

    In a series of New Jersey Supreme Court decisions known as Abbott v. Burke, the 28 (now 31) urban school districts serving the state's poorest students were ordered to create systems of high-quality preschool for all three- and four-year-old children, beginning in the 1999-2000 school year. The Abbott Preschool Program now serves approximately…

  10. Fulfilling the Promise of Abbott: The Lighthouse Assessment Process--Improving Programs through Measured Outcomes. Policy Progress, Spring 2004

    ERIC Educational Resources Information Center

    Association for Children of New Jersey, 2004

    2004-01-01

    In an attempt to better prepare young children for the challenges of kindergarten and first grade, the Supreme Court of New Jersey, in its 1998 landmark decision of "Abbott v. Burke" (Abbott V), required the State's poorest school districts to implement high quality, intensive preschool for all 3-and 4-year old children. To take…

  11. Accuracy and precision of four value-added blood glucose meters: the Abbott Optium, the DDI Prodigy, the HDI True Track, and the HypoGuard Assure Pro.

    PubMed

    Sheffield, Catherine A; Kane, Michael P; Bakst, Gary; Busch, Robert S; Abelseth, Jill M; Hamilton, Robert A

    2009-09-01

    This study compared the accuracy and precision of four value-added glucose meters. Finger stick glucose measurements in diabetes patients were performed using the Abbott Diabetes Care (Alameda, CA) Optium, Diagnostic Devices, Inc. (Miami, FL) DDI Prodigy, Home Diagnostics, Inc. (Fort Lauderdale, FL) HDI True Track Smart System, and Arkray, USA (Minneapolis, MN) HypoGuard Assure Pro. Finger glucose measurements were compared with laboratory reference results. Accuracy was assessed by a Clarke error grid analysis (EGA), a Parkes EGA, and within 5%, 10%, 15%, and 20% of the laboratory value criteria (chi2 analysis). Meter precision was determined by calculating absolute mean differences in glucose values between duplicate samples (Kruskal-Wallis test). Finger sticks were obtained from 125 diabetes patients, of which 90.4% were Caucasian, 51.2% were female, 83.2% had type 2 diabetes, and average age of 59 years (SD 14 years). Mean venipuncture blood glucose was 151 mg/dL (SD +/-65 mg/dL; range, 58-474 mg/dL). Clinical accuracy by Clarke EGA was demonstrated in 94% of Optium, 82% of Prodigy, 61% of True Track, and 77% of the Assure Pro samples (P < 0.05 for Optium and True Track compared to all others). By Parkes EGA, the True Track was significantly less accurate than the other meters. Within 5% accuracy was achieved in 34%, 24%, 29%, and 13%, respectively (P < 0.05 for Optium, Prodigy, and Assure Pro compared to True Track). Within 10% accuracy was significantly greater for the Optium, Prodigy, and Assure Pro compared to True Track. Significantly more Optium results demonstrated within 15% and 20% accuracy compared to the other meter systems. The HDI True Track was significantly less precise than the other meter systems. The Abbott Optium was significantly more accurate than the other meter systems, whereas the HDI True Track was significantly less accurate and less precise compared to the other meter systems.

  12. Detection of antibodies to hepatitis B core antigen using the Abbott ARCHITECT anti-HBc assay: analysis of borderline reactive sera.

    PubMed

    Ollier, Laurence; Laffont, Catherine; Kechkekian, Aurore; Doglio, Alain; Giordanengo, Valérie

    2008-12-01

    Routine use of the automated chemiluminescent microparticle immunoassay Abbott ARCHITECT anti-HBc for diagnosis of hepatitis B is limited in case of borderline reactive sera with low signal close to the cut-off index. In order to determine the significance of anti-HBc detection when borderline reactivity occurs using the ARCHITECT anti-HBc assay, a comparative study was designed. 3540 serum samples collected over a 2-month period in the hospital of Nice were examined for markers of HBV infection (HBsAg, anti-HBs and anti-HBc). One hundred seven samples with sufficient volume and with borderline reactivity by the ARCHITECT assay were tested by two other anti-HBc assays, a microparticle enzyme immunoassay (MEIA, AxSYM Core, Abbott Laboratories, IL, USA) and an enzyme linked fluorescent assay (ELFA, VIDAS Anti-HBc Total II, bioMérieux, Lyon, France). Only 46 samples were confirmed by the AxSYM and the VIDAS assays. Additional serological information linked to patient history showed that the remaining samples (61) were false positives (11), had low titer of anti-HBc antibodies (13), or were inconclusive (37). This comparative study highlighted the existence of a grey zone around the cut-off index. Confirmative results through a different immunoassay are needed to confirm the diagnosis of HBV on borderline reactive sera using the ARCHITECT anti-HBc assay.

  13. Early Childhood Education: The Sustainability of the Benefits of Preschool Participation in Abbott Districts

    ERIC Educational Resources Information Center

    Fernandez, Norma

    2010-01-01

    The landmark New Jersey Supreme Court school funding case, "Abbott v. Burke", established the availability of preschool for all three- and four-year-olds living within the state's thirty-one poorest districts as a means of eradicating the effects of poverty. Longitudinal studies have shown the value of high quality preschool programs for…

  14. Film shows hospital's neighborliness. Depicts Abbott Northwestern's work with Phillips neighborhood.

    PubMed

    Rees, Tom

    2003-01-01

    Abbott Northwestern Hospital, Minneapolis, worked with Twist, a production company also located in Minneapolis, to create a six-minute documentary about its role in the community. It affirms the hospital's commitment to the Phillips neighborhood and uses interviews with local residents, hoping to stimulate community action.

  15. 78 FR 54487 - Abbott Laboratories; Diagnostic-Hematology; Including On-Site Leased Workers From Manpower...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-04

    ... Employment and Training Administration Abbott Laboratories; Diagnostic--Hematology; Including On-Site Leased... Laboratories, Diagnostic--Hematology division, including on-site leased workers from Manpower Service Group... to the production of hematology reagents and instruments. The company reports that workers...

  16. 78 FR 23220 - Foreign-Trade Zone 22-Chicago, Illinois, Authorization of Production Activity, Abbott...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-18

    ... Foreign-Trade Zones Board Foreign-Trade Zone 22--Chicago, Illinois, Authorization of Production Activity, Abbott Laboratories, Inc., AbbVie, Inc. (Pharmaceutical Production), North Chicago, Illinois, Area On... production authority within Subzones 22F and 22S, respectively, at sites located in the North Chicago and...

  17. Preconcepts in Physics. Report to the John Abbott College Research and Development Committee.

    ERIC Educational Resources Information Center

    Dickie, L. O.

    This study was conducted to examine the basic conceptual knowledge and understanding of physics possessed by students enrolled in introductory physics, mechanics and waves and optics courses at John Abbott College (JAC). The study used a 36-item multiple-choice test of physics preconcepts developed by Halloun and Hestenes. The Halloun and Hestenes…

  18. The Labour Process of Teaching at John Abbott College (Part One).

    ERIC Educational Resources Information Center

    Johnson, Walter

    This survey was conducted at John Abbott College to gauge teachers' responses to issues concerning their job satisfaction, interaction with colleagues, perceptions of student abilities, and perceptions concerning union negotiating priorities and areas of conflict within the institutional environment. Of the 75 teachers contacted, 47 returned…

  19. Breaking Ground: Rebuilding New Jersey's Urban Schools. The Abbott School Construction Program

    ERIC Educational Resources Information Center

    Ponessa, Joan

    2004-01-01

    This report presents a brief history of the Abbott School Construction Program, describes the implementation to date, lays out some current challenges, and outlines lessons learned from the process so far--what is known now about how such an initiative should be planned and carried out. The report is intended to illuminate the complex process of…

  20. Engaging Parents, Families and the Community to Improve Student Achievement. Abbott Implementation Resource Guide

    ERIC Educational Resources Information Center

    Henderson, Anne

    2004-01-01

    During the summer of 2003, a statewide committee of representative educational stakeholders on "cooperative rulemaking" was convened jointly by the Department of Education and the Education Law Center. The Supreme Court in "Abbott X" had directed the establishment of this committee to develop new regulations more consistent…

  1. 75 FR 340 - Approval for Expansion of Subzone 22F, Abbott Molecular, Inc. (Pharmaceutical and Molecular...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-05

    ... [Federal Register Volume 75, Number 2 (Tuesday, January 5, 2010)] [Notices] [Pages 340-341] [FR Doc No: E9-31315] DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [Order No. 1654] Approval for Expansion of Subzone 22F, Abbott Molecular, Inc. (Pharmaceutical and Molecular Diagnostic Products), Chicago...

  2. Analytical performance of the Abbott Architect i2000 tacrolimus assay in Chinese patients after renal transplantation.

    PubMed

    Li, Z Y; Yan, C L; Yan, R; Feng, Z R

    2010-12-01

    Monitoring of tacrolimus concentrations has played a crucial role to control the efficacy versus adverse effects of treatment, because of the drug's narrow therapeutic range, inter- and intraindividual variabilities, and drug interactions mediated by hepatic cytochrome P450. Therefore, the stability of methods to monitor tacrolimus is of major importance. This study evaluated the analytical performance of the Abbott Architect i2000 tacrolimus assay, which was recently released in China to monitor tacrolimus therapy. We compared the results using the Abbott Architect i2000 Tacrolimus assay with the traditional Abbott IMx method. We measured concentrations of tacrolimus in 100 samples from renal transplant patients by Architect i2000 and the commonly used Abbott IMx. We observed that the total %CV of the Architect i2000 assay was <10%, both at low and high concentration levels, with a functional sensitivity of <0.5 ng/mL. The Architect i2000 assay was linear over the reportable range with recoveries ranging from 90.6% to 106.7%. In addition, this assay was not affected by high concentrations of hemoglobin, lipids, or bilirubin in the samples. The 2 assays yielded similar results. The regression equation obtained from the Passing Bablok analysis was: y = 0.8788x - 0.3485 with a Spearman correlation coefficient (r) of 0.9922. The bias plot between the Architect i2000 and Abbott IMx assay yielded an average negative bias (-1.4 ng/mL). We concluded that, because of its high precision and sensitivity, low cross-reactivity, and acceptable accuracy, the Architect i2000 assay is a suitable alternative to monitor tacrolimus concentrations in renal transplant recipients. Copyright © 2010 Elsevier Inc. All rights reserved.

  3. National Parks

    Treesearch

    Jill S. Baron; Craig D. Allen; Erica Fleishman; Lance Gunderson; Don McKenzie; Laura Meyerson; Jill Oropeza; Nate Stephenson

    2008-01-01

    Covering about 4% of the United States, the 338,000 km2 of protected areas in the National Park System contain representative landscapes of all of the nation's biomes and ecosystems. The U.S. National Park Service Organic Act established the National Park System in 1916 "to conserve the scenery and the natural and historic objects and...

  4. 77 FR 38882 - Notice of Availability of a Draft Environmental Impact Statement, for the Chicago, IL to St...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-29

    ... Forest, IL 60452 Odell Public Library District, 301 East Richard Street, Odell, IL 60460 Orland Park... Taylor Street, Towanda, IL 61776 Venice Public Library, 325 Broadway Avenue, Venice, IL 62090 Grand...

  5. Liver Rapid Reference Set Application: Hemken - Abbott (2015) — EDRN Public Portal

    Cancer.gov

    The aim for this testing is to find a small panel of biomarkers (n=2-5) that can be tested on the Abbott ARCHITECT automated immunoassay platform for the early detection of hepatocellular carcinoma (HCC). This panel of biomarkers should perform significantly better than alpha-fetoprotein (AFP) alone based on multivariate statistical analysis. This testing of the EDRN reference set will help expedite the selection of a small panel of ARCHITECT biomarkers for the early detection of HCC. The panel of ARCHITECT biomarkers Abbott plans to test include: AFP, protein induced by vitamin K absence or antagonist-II (PIVKA-II), golgi protein 73 (GP73), hepatocellular growth factor (HGF), dipeptidyl peptidase 4 (DPP4) and DPP4/seprase (surface expressed protease) heterodimer hybrid. PIVKA-II is abnormal des-carboxylated prothrombin (DCP) present in vitamin K deficiency.

  6. Evaluation of a commercial ligase chain reaction kit (Abbott LCx) for direct detection of Mycobacterium tuberculosis in pulmonary and extrapulmonary specimens.

    PubMed Central

    Tortoli, E; Lavinia, F; Simonetti, M T

    1997-01-01

    Direct detection of Mycobacterium tuberculosis by means of a commercial ligase chain reaction DNA amplification method (LCx M. tuberculosis; Abbott Diagnostics Division, Abbott Park, Ill.) was investigated with 511 (including 147 extrarespiratory) specimens collected from 358 patients. LCx results were compared with standard microbiological data, and conflicting cases were resolved according to the final clinical diagnosis. M. tuberculosis was detected in 45 of 358 subjects by means of the LCx test. The test was negative for all 30 specimens with mycobacteria other than M. tuberculosis. The sensitivity, specificity, and positive and negative predictive values for the LCx test, compared with culture results, were 93.90, 92.31, 70.00, and 98.75%, respectively; these values rose in resolved cases to 95.53, 99.25, 97.27, and 98.75%, respectively. With respiratory specimens, for which the LCx system is licensed, the sensitivity reached 98.97%. In patients with a final clinical diagnosis of tuberculosis the sensitivity of the LCx system was 89.36% compared to 82.98% for cultures and 78.72% for microscopy. We conclude that the LCx test is user friendly, rapid, fairly sensitive, and highly specific. It can also be effectively used on extrapulmonary specimens provided possible false-negative results are taken into account. However, the use of LCx test appears to be less appropriate for the monitoring of antituberculosis therapy, as the majority of samples from treated tuberculosis patients gave consistently positive results, despite the sterilization of cultures. PMID:9276432

  7. BRSCW Reference Set Application: Karen Abbott -University of Arkansas (2014) — EDRN Public Portal

    Cancer.gov

    Our earlier glycoproteomic studies have identified bisecting glycoslyation and core fucosylation changes on particular glycoproteins in endometrioid ovarian cancer tissues and plasma (Abbott et al, 2010, Proteomics). We have validated that these glycan changes occur on the same glycoproteins in serous ovarian cancer plasma using a lectin-pull down western blot assays. We would like to used pooled reference samples to develop a sensitive magnetic bead-based assay to detect these glycoproteins with bisecting and core fucosylation changes.

  8. Revisiting Abbott Thayer: non-scientific reflections about camouflage in art, war and zoology

    PubMed Central

    Behrens, Roy R.

    2008-01-01

    This paper reviews the achievements of Abbott Handerson Thayer (1849–1921), an American painter and naturalist whose pioneering writings on animal camouflage addressed shared concerns among artists, zoologists and military tacticians. It discusses his beliefs about camouflage (both natural and military) in the context of his training as an artist, with particular emphasis on three of his major ideas: countershading, ruptive (or disruptive) coloration and background picturing. PMID:19000975

  9. Verification of Abbott 25-OH-vitamin D assay on the architect system.

    PubMed

    Hutchinson, Katrina; Healy, Martin; Crowley, Vivion; Louw, Michael; Rochev, Yury

    2017-04-01

    Analytical and clinical verification of both old and new generations of the Abbott total 25-hydroxyvitamin D (25OHD) assays, and an examination of reference Intervals. Determination of between-run precision, and Deming comparison between patient sample results for 25OHD on the Abbott Architect, DiaSorin Liaison and AB SCIEX API 4000 (LC-MS/MS). Establishment of uncertainty of measurement for 25OHD Architect methods using old and new generations of the reagents, and estimation of reference interval in healthy Irish population. For between-run precision the manufacturer claims 2.8% coefficients of variation (CVs) of 2.8% and 4.6% for their high and low controls, respectively. Our instrument showed CVs between 4% and 6.2% for all levels of the controls on both generations of the Abbott reagents. The between-run uncertainties were 0.28 and 0.36, with expanded uncertainties 0.87 and 0.98 for the old and the new generations of reagent, respectively. The difference between all methods used for patients' samples was within total allowable error, and the instruments produced clinically equivalent results. The results covered the medical decision points of 30, 40, 50 and 125 nmol/L. The reference interval for total 25OHD in our healthy Irish subjects was lower than recommended levels (24-111 nmol/L). In a clinical laboratory Abbott 25OHD immunoassays are a useful, rapid and accurate method for measuring total 25OHD. The new generation of the assay was confirmed to be reliable, accurate, and a good indicator for 25OHD measurement. More study is needed to establish reference intervals that correctly represent the healthy population in Ireland.

  10. Abbott AxSYM Vancomycin II assay: multicenter evaluation and interference studies.

    PubMed

    Azzazy, H M; Chou, P P; Tsushima, J H; Troxil, S; Gordon, M; Avers, R J; Chiappetta, E; Duh, S H; Christenson, R H

    1998-04-01

    The authors evaluated the performance characteristics of the Abbott AxSYM Vancomycin II immunoassay in sera of patients with (n = 93 samples) and without (n = 327 patients) renal dysfunction. Correlation of vancomycin measurements with the Abbott AxSYM Vancomycin, Abbott TDx/TDxFLx, Syva enzyme-multiplied immunoassay technique (EMIT), DuPont automated chemistry analyzer (ACA), and high-performance liquid chromatography methods showed acceptable correlation as indicated by: slope values >0.95, r-values >0.97, y-intercepts <1.7 microg/ml, and S(y/x) ranging from 9% to 15% of the average vancomycin value. The AxSYM Vancomycin II assay showed acceptable correlation with AxSYM vancomycin, TDx/TDxFLx, and high-performance liquid chromatography methods in 93 samples from patients with renal dysfunction. This monoclonal antibody-based assay showed no apparent interference from the presence of human antimouse antibody (HAMA) or the microbiologically inactive vancomycin crystalline degradation product (CDP). The authors conclude that the AxSYM Vancomycin II assay showed satisfactory agreement with other methods tested in this study.

  11. Park It!

    ERIC Educational Resources Information Center

    Sartorius, Tara Cady

    2010-01-01

    Many artists visit national parks to draw, paint and take photographs of some of the most amazing scenery on earth. Raw nature is one of the greatest inspirations to an artist, and artists can be credited for helping inspire the government to create the National Park System. This article features Thomas Moran (1837-1926), one of the artists who…

  12. Park It!

    ERIC Educational Resources Information Center

    Sartorius, Tara Cady

    2010-01-01

    Many artists visit national parks to draw, paint and take photographs of some of the most amazing scenery on earth. Raw nature is one of the greatest inspirations to an artist, and artists can be credited for helping inspire the government to create the National Park System. This article features Thomas Moran (1837-1926), one of the artists who…

  13. Direct detection of Mycobacterium tuberculosis and drug resistance in respiratory specimen using Abbott Realtime MTB detection and RIF/INH resistance assay.

    PubMed

    Tam, Kingsley King-Gee; Leung, Kenneth Siu-Sing; To, Sabrina Wai-Chi; Siu, Gilman Kit-Hang; Lau, Terrence Chi-Kong; Shek, Victor Chi-Man; Tse, Cindy Wing-Sze; Wong, Samson Sai-Yin; Ho, Pak-Leung; Yam, Wing-Cheong

    2017-10-01

    Abbott RealTime MTB (Abbott-RT) in conjunction with Abbott RealTime MTB RIF/INH Resistance (Abbott-RIF/INH) is a new, high-throughput automated nucleic acid amplification platform (Abbott-MDR) for detection of Mycobacterium tuberculosis complex (MTBC) and the genotypic markers for rifampicin (RIF) and isoniazid (INH) resistance directly from respiratory specimens. This prospective study evaluated the diagnostic performance of this new platform for MTBC and multidrug-resistant tuberculosis (MDR-TB) using 610 sputum specimens in a tuberculosis high-burden setting. Using conventional culture results and clinical background as reference standards, Abbott-RT exhibited an overall sensitivity and specificity of 95.2% and 99.8%, respectively. Genotypic RIF/INH resistance of 178 "MTB detected" specimens was subsequently analyzed by Abbott-RIF/INH. Compared to phenotypic drug susceptibility test results, Abbott-RIF/INH detected resistance genotypic markers in 84.6% MDR-TB, 80% mono-RIF-resistant and 66.7% mono-INH-resistant specimens. Two of the RIF-resistant specimens carried a novel single, nonsense mutation at rpoB Q513 and in silico simulation demonstrated that the truncated RpoB protein failed to bind with other subunits for transcription. Overall, Abbott-MDR platform provided high throughput and reliable diagnosis of MDR-TB within a TB high-burden region. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. Clinical utility of Abbott Precision Xceed Pro® ketone meter in diabetic patients.

    PubMed

    Yu, Hoi-Ying Elsie; Agus, Michael; Kellogg, Mark D

    2011-11-01

    Diagnosis and management of diabetic ketoacidosis (DKA) often rely on the measurement of urine ketones along with blood glucose, anion gap, and pH. These values, however, do not reliably reflect the severity of ketoacidosis. The Abbott Precision Xceed Pro® meter is an FDA-approved device that quantitatively measures β-hydroxybutyrate (BOH) in whole blood. This study was undertaken to determine whether the ketone meter meets the analytical criteria to aid DKA diagnosis and management in the hospital. 54 heparinized venous whole blood BOH concentrations from 27 diabetic patients were measured by the Abbott meter, and compared with the plasma BOH concentrations measured with Stanbio reagent (reference method). Measurements were done in the hospital central laboratory. Of the 54 pairs of specimens analyzed, 17 pairs displayed a difference of >15% between the two methods. Nearly all discrepant points occurred when BOH >5 mmol/L (reference method). Linearity evaluation revealed that the meter is not linear from 0.0 to 8.0 mmol/L, contrary to the claim by the manufacturer. Further, we identified acetoacetate, a metabolite commonly present in DKA patients, as a potential interfering substance for the meter BOH measurement. BOH measurements by the Abbott meter up to 3 mmol/L correlate well with the reference method, but become discrepant above that point. While this characteristic may be useful in the diagnosis of DKA, it may not allow clinicians to serially follow the response to therapy in hospitalized DKA patients with BOH values greater than 5 mmol/L (reference method). © 2011 John Wiley & Sons A/S.

  15. Parkes Telescope

    NASA Image and Video Library

    2013-07-08

    This image shows the Parkes telescope in Australia, part of the Commonwealth Scientific and Industrial Research Organization. Researchers used the telescope to detect the first population of radio bursts known to originate from beyond our galaxy.

  16. Subsurface damage distribution characterization of ground surfaces using Abbott-Firestone curves.

    PubMed

    Laheurte, Raynald; Darnis, Philippe; Darbois, Nathalie; Cahuc, Olivier; Neauport, Jérôme

    2012-06-04

    Measurement of subsurface damage (SSD) induced by grinding process is of major interest in the development of high laser damage fused silica optical components manufacturing processes. Most SSD measurements methods give only access to the peak to peak value. We herein report on the benefit of using Abbott-Firestone curves to get an insight of the SSD distribution inside the optical material. We evidence on various diamond wheel ground fused silica substrates that such an approach is complementary to a classical SSD peak to peak measurement and bring useful information to optimize a grinding process.

  17. Park Smart

    NASA Technical Reports Server (NTRS)

    1999-01-01

    The Parking Garage Automation System (PGAS) is based on a technology developed by a NASA-sponsored project called Robot sensorSkin(TM). Merritt Systems, Inc., of Orlando, Florida, teamed up with NASA to improve robots working with critical flight hardware at Kennedy Space Center in Florida. The system, containing smart sensor modules and flexible printed circuit board skin, help robots to steer clear of obstacles using a proximity sensing system. Advancements in the sensor designs are being applied to various commercial applications, including the PGAS. The system includes a smartSensor(TM) network installed around and within public parking garages to autonomously guide motorists to open facilities, and once within, to free parking spaces. The sensors use non-invasive reflective-ultrasonic technology for high accuracy, high reliability, and low maintenance. The system is remotely programmable: it can be tuned to site-specific requirements, has variable range capability, and allows remote configuration, monitoring, and diagnostics. The sensors are immune to interference from metallic construction materials, such as rebar and steel beams. Inside the garage, smart routing signs mounted overhead or on poles in front of each row of parking spots guide the motorist precisely to free spaces.

  18. Comparison of the Abbott Realtime HIV-1 and HCV viral load assays with commercial competitor assays.

    PubMed

    Schutten, Martin

    2008-07-01

    The introduction of commercially available quantitative HIV-1 RNA detection methods at the end of the last century has had a significant impact on the management of patients requiring treatment. Similarly for hepatitis C virus (HCV), clinical decision-making with respect to initiation and prolonging therapy is largely based on data from viral load assays. The methods developed in the early 1990s and further improved since then still have significant drawbacks. For example, they are labor intensive, have a small dynamic range and are contamination sensitive. The development of real-time detection techniques for reverse transcription PCR has in part solved these problems. In the present review the advantages and disadvantages of the recently marketed Abbott Realtime HCV and HIV-1 viral load assays relative to their competitors will be discussed.

  19. The children's republic of science in the antebellum literature of Samuel Griswold Goodrich and Jacob Abbott.

    PubMed

    Pandora, Katherine

    2009-01-01

    The antebellum years in the United States were marked by vigorous debates about national identity in which issues of hierarchy, authority, and democratic values came under intense scrutiny. During this period, a prime objective of indigenous authors writing for American children was educating the young so they would be ready to assume their republican responsibilities. The question of how depictions and discussions about nature and science were deployed toward this end is explored by examining key texts about nature and science from the era's two most prolific and popular children's authors--Samuel Griswold Goodrich (1793-1860) and Jacob Abbott (1803-79)--and highlighting assumptions within these works about what the proper relationship should be between the search for scientific knowledge and the larger polity.

  20. Evaluating lubricating capacity of vegetal oils using Abbott-Firestone curve

    NASA Astrophysics Data System (ADS)

    Georgescu, C.; Cristea, G. C.; Dima, C.; Deleanu, L.

    2017-02-01

    The paper presents the change of functional parameters defined on the Abbott-Firestone curve in order to evaluate the surface quality of the balls from the four ball tester, after tests done with several vegetable oils. The tests were done using two grades of rapeseed oil (degummed and refined) and two grades of soybean oil (coarse and degummed) and a common transmission oil (T90). Test parameters were 200 N and 0.576 m/s (1500 rpm) for 60 minutes. For the refined rapeseed oil, the changes in shape of the Abbott-Firestone curves are more dramatic, these being characterized by high values of Spk (the average value for the wear scars on the three balls), thus being 40% of the sum Svk + Sk + Spk, percentage also obtained for the soybean oil, but the value Spk being lower. For the degummed soybean oil, the profile height of the wear scars are taller than those obtained after testing the coarse soybean oil, meaning that the degumming process has a negative influence on the worn surface quality and the lubricating capacity of this oil. Comparing the surface quality of the wear scars on fixed tested balls is a reliable method to point out the lubricant properties of the vegetable oils, especially if they are compared to a “classical” lubricant as a non-additivated transmission mineral oil T90. The best surface after testing was obtained for the soybean oil, followed by T90 oil and the degummed grades of the soybean oil and rapeseed oil (these three giving very close values for the functional parameters), but the refined rapeseed oil generated the poorest quality of the wear scars on the balls, under the same testing conditions.

  1. ACE Parking Workplace Education.

    ERIC Educational Resources Information Center

    Sweetwater Union High School District, Chula Vista, CA.

    This manual is designed for use in a four-session workshop to help new parking garage employees enhance their skills in the following areas: understanding the functions of parking employees, computing parking rates and filling out parking lot reconciliation forms, preparing miscellaneous parking lot forms and developing effective communication and…

  2. 78 FR 48902 - Notice of Intent To Repatriate Cultural Items: Field Museum of Natural History, Chicago, IL...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-12

    ..., Chicago, IL; Correction AGENCY: National Park Service, Interior. ACTION: Notice; correction. SUMMARY: The... Director, Field Museum of Natural History, 1400 South Lake Shore Drive, Chicago, IL 60605, telephone (312... History, Chicago, IL. This notice is published as part of the National Park Service's...

  3. 1. AERIAL OVERVIEW OF LINCOLN PARK, LOOKING NNW ALONG NORTH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. AERIAL OVERVIEW OF LINCOLN PARK, LOOKING NNW ALONG NORTH LAKE SHORE DRIVE. PASSERELLE IS ROUGHLY HALFWAY UP, OPPOSITE NORTH AVENUE BATHING BEACH AT MIDDLE RIGHT OF FRAME. - Passerelle in Lincoln Park, Spanning North Lake Shore Drive (U.S. Route 41) on axis of East Menomonee Street, Chicago, Cook County, IL

  4. National Environmental Research Parks

    SciTech Connect

    Not Available

    1994-07-01

    The National Environmental Research Parks are outdoor laboratories that provide opportunities for environmental studies on protected lands that act as buffers around Department of Energy (DOE) facilities. The research parks are used to evaluate the environmental consequences of energy use and development as well as the strategies to mitigate these effects. They are also used to demonstrate possible environmental and land-use options. The seven parks are: Fermilab National Environmental Research Park; Hanford National Environmental Research Park; Idaho National Environmental Research Park; Los Alamos National Environmental Research Park; Nevada National Environmental Research Park; Oak Ridge National Environmental Research Park; and Savannah River National Environmental Research Park. This document gives an overview of the events that led to the creation of the research parks. Its main purpose is to summarize key points about each park, including ecological research, geological characteristics, facilities, and available databases.

  5. Application of the EMIT 2000 Tacrolimus assay on the Abbott Architect c8000 high volume clinical chemistry analyzer.

    PubMed

    Boer, Klas; Deufel, Thomas; Schmidt, Dirk; Streck, Sibylle; Kiehntopf, Michael

    2006-10-01

    Evaluation of the performance of the EMIT 2000 Tacrolimus assay on the Abbott Architect c8000 analyzer. Imprecision studies were performed and patient samples were assayed by EMIT assay and by LC-MS/MS. Limit of quantification was established at 2.8 microg/L. A positive bias of 17.5% between results measured on EMIT and on LC-MS/MS was detected. EMIT 2000 Tacrolimus assay is suitable for automated analyses of Tacrolimus on the Architect c8000.

  6. Glucose meters: evaluation of the new formulation measuring strips from Roche (Accu-Chek) and Abbott (MediSense).

    PubMed

    Dimeski, G; Jones, B W; Tilley, V; Greenslade, M N; Russell, A W

    2010-07-01

    Both Roche and Abbott have released new glucose meter strips. They supply the entire Australian hospital market. The present study compared the performance of the new strips utilizing various specimen types (capillary, venous lithium heparin whole blood, venous lithium heparin plasma and serum) and evaluated how well they comply with the International Standards Organization (ISO) 15197 criteria. The study included imprecision, patient comparison and interference studies. Participants with and without diabetes were recruited to evaluate the performance of various specimen types against the Beckman DxC800 glucose method. The strips were tested for different interferences: galactose, maltose, lactose, Icodextrin, Intragam, paracetamol, sodium, ascorbic acid, variable strip storage temperature, haematocrit, haemolysis and lipaemia. The imprecision of the two strips was approximately 5% or less, except for the Abbott strip at very low values (1.4 mmol/L), approximately 7%. In total, 78% and 84%, respectively, of the results from the finger prick capillary specimens with the Roche (Accu-Chek Performa meter) and Abbott (Optium Xceed meter) strips, not 95% or greater as recommended by the ISO guideline, were within the recommended limits compared with reference plasma estimation on laboratory analysers. Galactose, ascorbic acid, haematocrit and sodium on the Roche and ascorbic acid and haematocrit on the Abbott strip continue to interfere to a variable degree with the glucose measurement. Analytically small differences exist between the glucose meter strips. The most significant analytical difference with the strips was at low glucose levels when compared with laboratory analyses and this may be of clinical importance. The impact of some of the interferences is variable between the two strips. Individuals, health-care professionals and health-care institutions should consider these data when selecting glucose meters for the management of people with diabetes mellitus.

  7. Hidden processes in structural representations: A reply to Abbott, Austerweil, and Griffiths (2015).

    PubMed

    Jones, Michael N; Hills, Thomas T; Todd, Peter M

    2015-07-01

    In recent work exploring the semantic fluency task, we found evidence indicative of optimal foraging policies in memory search that mirror search in physical environments. We determined that a 2-stage cue-switching model applied to a memory representation from a semantic space model best explained the human data. Abbott, Austerweil, and Griffiths demonstrate how these patterns could also emerge from a random walk applied to a network representation of memory based on human free-association norms. However, a major representational issue limits any conclusions that can be drawn about the process model comparison: Our process model operated on a memory space constructed from a learning model, whereas their model used human behavioral data from a task that is quite similar to the behavior they attempt to explain. Predicting semantic fluency (e.g., how likely it is to say cat after dog in a sequence of animals) from free association (how likely it is to say cat when given dog as a cue) should be possible with a relatively simple retrieval mechanism. The 2 tasks both tap memory, but they also share a common process of retrieval. Assuming that semantic memory is a network from free-association behavior embeds variance due to the shared retrieval process directly into the representation. A simple process mechanism is then sufficient to simulate semantic fluency because much of the requisite process complexity may already be hidden in the representation. (PsycINFO Database Record

  8. Survey of fishes and environmental conditions in Abbotts Lagoon, Point Reyes National Seashore, California

    USGS Publications Warehouse

    Saiki, M.K.; Martin, B.A.

    2001-01-01

    This study was conducted to gain a better understanding of fishery resources in Abbotts Lagoon, Point Reyes National Seashore. During February/March, May, August, and November 1999, fish were sampled with floating variable-mesh gill nets and small minnow traps from as many as 14 sites in the lagoon. Water temperature, dissolved oxygen, pH, total ammonia(NH3 + NH4+), salinity, turbidity, water depth, and bottom substrate composition were also measured at each site. A total of 2,656 fish represented by eight species was captured during the study. Gill nets captured Sacramento perch, Archoplites interruptus; largemouth bass, Micropterus salmoides; Pacific herring, Clupea pallasi; prickly sculpin, Cottus asper, silver surfperch, Hyperprosopon ellipticum; longfin smelt, Spirinchus thaleichthys; and striped bass, Morone saxatilis; whereas minnow traps captured Sacramento perch; prickly sculpin; and threespine stickleback, Gasterosteus aculeatus. Cluster analysis (Ward's minimum variance method of fish catch statistics identified two major species assemblages-the first dominated by Sacramento perch and, to a lesser extent, by largemouth bass, and the second dominated by Pacific herring and threespine stickleback. Simple discriminant analysis of environmental variables indicated that salinity contributed the most towards separating the two assemblages.

  9. Two-centre evaluation of the Abbott CD3500 blood counter.

    PubMed

    al-Ismail, S A; Bond, K; Carter, A B; Grant, D; Machin, S J; Patterson, K G; Pearman, K J; Pollard, Y C; Popeck, M

    1995-03-01

    The CD3500 blood counter (Abbott Laboratories) is a 33 parameter fully automated blood counter that produces a five part differential count with flagging of leucocyte abnormalities. In this evaluation excellent correlation between CD3500 and Coulter STKR blood counter was found for all red cell and platelet parameters on the 221 samples tested. Studies of carryover, mixing efficiency and precision also gave excellent results. There was a good correlation with manual 400 cell differential counts for neutrophils, lymphocytes, monocytes and eosinophils for the 468 samples compared. Correlation of CD3500 and manual basophil counts was poor. Normal samples stored at 4 degrees C and analysed while cold showed satisfactory stability for WBC, RBC, Hb, MCV and platelets for 48 h and a stable differential for 24 h. Correlation with the differential count produced by the Coulter STKS showed good correlation for neutrophils, lymphocytes, monocytes and eosinophils; correlation with STKS basophils was poor. False positive flagging rate varied between 8.9% (Band and/or IG) and 0.9% (NRBC) depending on the nature of the flag; 5.8% of samples exhibited two or more false positive flags. No significant breakdowns were encountered during the period of the evaluation. The scatterplot displays of laser light scatter produced by the instrument provide an interesting adjunct to conventional morphology.

  10. Yellowstone Park

    NASA Image and Video Library

    2002-10-15

    Thirteen years after devastating forest fires burned over 1.6 million acres in Yellowstone National Park, the scars are still evident. In this simulated natural color ASTER image, burned areas appear gray, in contrast to the dark green of unburned forests. The image covers an area of 60 x 63 km. This image was acquired on July 2, 2001 by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite. With its 14 spectral bands from the visible to the thermal infrared wavelength region, and its high spatial resolution of 15 to 90 meters (about 50 to 300 feet), ASTER images Earth to map and monitor the changing surface of our planet. http://photojournal.jpl.nasa.gov/catalog/PIA03875

  11. National Park Service Careers.

    ERIC Educational Resources Information Center

    National Park Service (Dept. of Interior), Washington, DC.

    This booklet offers information on the employment needs of and career opportunities in the National Park Service. General information on the Service and employment is followed by specific information on these career opportunities: park ranger, park aide and technician, park police, administrative careers, and maintenance, trade, and craft…

  12. A practical application of computer pattern recognition research: the Abbott ADC-500 differential classifier.

    PubMed

    Green, J E

    1979-01-01

    The ADC-500 is a new blood cell differential classifier manufactured by Abbott Laboratories. It performs 500-cell leukocyte differentials on both normal and abnormal cells, evaluates red cell morphology and estimates platelet sufficiency at a rate of 40 to 50 samples per hour in stand-alone operation. The ADC-500 system consists of a spinner which prepares a uniform blood monolayer on a slide, a stainer which reproducibly stains the slide with Wright's stain, an encoder which attaches an instrument and human readable identification to the slide and an analyzer which accepts a stack of up to 50 slides, evaluates these slides and prints the results and the slide identification on report forms. The system's analysis rate, which represents a 5- to 10-fold increase over other commercially available differential counters, requires a number of specialized techniques for its realization. One key to this performance is the development of a high speed X-Y slide positioning stage which can move to a new cell and settle in 50 msec. Another is the high degree of parallelism used in the system structure and the pipelining of the data processing. A third is the development of uniform and repeatable sample preparation modules. Within the analyzer module, the autofocus, white cell acquisition and high resolution cell analysis systems are independent and operate in parallel. At the same time within the high resolution cell analysis system, one cell is acquired; the digitized image of a second processed; and a third is classified using pattern recognition techniques. All of these tasks, except focus, are under the control of a minicomputer system. Tests of the system reveal good accuracy and an improvement in precision due to the increase in the number of counted cells.

  13. Evaluation of the Abbott IMx automated immunoassay of prostate-specific antigen.

    PubMed

    Vessella, R L; Noteboom, J; Lange, P H

    1992-10-01

    We detail the performance characteristics of the new IMx PSA immunoassay developed by Abbott Laboratories, addressing PSA recovery, assay reproducibility, standard curve storage, lower limit of detection, dilution linearity, and correlation with the Hybritech Tandem-R PSA immunoassay. We analyzed 686 sera for PSA retrospectively, testing 555 of these concurrently with the IMx and the Tandem-R immunoassays. The IMx PSA standard curve was linear from 0 to 100 micrograms/L, and curve storage was maintained for 4 weeks. The lower limit of detection of the IMx PSA assay was < or = 0.03 microgram/L; allowing for the assay precision yielded a biological detection limit of 0.06 microgram/L. We conservatively set the clinical threshold at 0.1 microgram/L. Regression analysis of dilution linearity involving 10 samples (0.44-200 micrograms/L) resulted in coefficients of correlation ranging from 0.9972 to 1.000. Reproducibility studies with 18 specimens within the range of 0.39-413.67 micrograms/L gave intra- and interassay CVs < 6.5%. The interassay 95% confidence interval for a specimen containing 0.06 microgram of PSA per liter was 0.03-0.09 microgram/L. Correlation between IMx and Tandem-R PSA assay results was excellent: r = 0.9909 and slope = 0.95. Overall, the IMx PSA immunoassay, with the conveniencies of automation, curve storage, and nonisotopic handling, provided an improved lower limit of PSA detection, which allows for earlier indication of residual or recurrent disease after radical prostatectomy.

  14. Diagnostic performance of the variant lymphocyte flag of the Abbott Cell-Dyn 4000 haematology analyser.

    PubMed

    Hoffmann, J J M L; Hoedemakers, R M J

    2004-02-01

    In addition to differential cell counts, modern haematology analysers generate suspect flags if abnormal cells are detected. Reports on validation of suspect flags are scarce. We have routine experience with the Abbott Cell-Dyn 4000 analyser for over 5 years and have previously demonstrated the utility of the blast flag. Here we report a similar study on the performance of the analyser's Variant Lymphocyte (VL) flag. Evaluation of the diagnostic performance of the Cell-Dyn 4000 VL flag, as compared with lymphocyte morphology in blood smears. In addition, we investigated the usefulness of the numerical VL flag confidence index as provided by the analyser. All samples generating a VL flag were reviewed over a 5-month period. We also reviewed smears from patients with known lymphoid disorders, even if the analyser did not flag the sample. Two experienced investigators assessed lymphocyte morphology independently. In total, 187 samples were included in the study, of which 183 had a VL flag and four had not. Of the 183 flagged samples, 83 appeared to have abnormal lymphocyte morphology and 100, normal lymphocyte morphology. The sensitivity of the VL flag for detecting abnormal lymphocytes was 0.95 and the positive predictive value was 0.44. Using ROC analysis of the VL flag confidence index, the area under the ROC curve was 0.58 (95% confidence interval 0.50-0.65). The Cell-Dyn VL flag has reasonable sensitivity but a high false-positive rate. In addition, its performance is insufficient for detecting clinically relevant abnormal lymphocytes. As the VL flag appeared to rely mainly on numerical criteria, it has no added value over numerical criteria defined by the laboratory.

  15. Yellowstone Park

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Thirteen years after devastating forest fires burned over 1.6 million acres in Yellowstone National Park, the scars are still evident. In this simulated natural color ASTER image, burned areas appear gray, in contrast to the dark green of unburned forests. The image covers an area of 60 x 63 km. This image was acquired on July 2, 2001 by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite. With its 14 spectral bands from the visible to the thermal infrared wavelength region, and its high spatial resolution of 15 to 90 meters (about 50 to 300 feet), ASTER images Earth to map and monitor the changing surface of our planet.

    ASTER is one of five Earth-observing instruments launched December 18, 1999, on NASA's Terra satellite. The instrument was built by Japan's Ministry of Economy, Trade and Industry. A joint U.S./Japan science team is responsible for validation and calibration of the instrument and the data products.

    The broad spectral coverage and high spectral resolution of ASTER will provide scientists in numerous disciplines with critical information for surface mapping, and monitoring of dynamic conditions and temporal change. Example applications are: monitoring glacial advances and retreats; monitoring potentially active volcanoes; identifying crop stress; determining cloud morphology and physical properties; wetlands evaluation; thermal pollution monitoring; coral reef degradation; surface temperature mapping of soils and geology; and measuring surface heat balance.

    Dr. Anne Kahle at NASA's Jet Propulsion Laboratory, Pasadena, California, is the U.S. Science team leader; Bjorn Eng of JPL is the project manager. The Terra mission is part of NASA's Earth Science Enterprise, a long- term research effort to understand and protect our home planet. Through the study of Earth, NASA will help to provide sound science to policy and economic decision-makers so as to better life here, while developing the

  16. HIV-1 viral load measurement in venous blood and fingerprick blood using Abbott RealTime HIV-1 DBS assay.

    PubMed

    Tang, Ning; Pahalawatta, Vihanga; Frank, Andrea; Bagley, Zowie; Viana, Raquel; Lampinen, John; Leckie, Gregor; Huang, Shihai; Abravaya, Klara; Wallis, Carole L

    2017-07-01

    HIV RNA suppression is a key indicator for monitoring success of antiretroviral therapy. From a logistical perspective, viral load (VL) testing using Dried Blood Spots (DBS) is a promising alternative to plasma based VL testing in resource-limited settings. To evaluate the analytical and clinical performance of the Abbott RealTime HIV-1 assay using a fully automated one-spot DBS sample protocol. Limit of detection (LOD), linearity, lower limit of quantitation (LLQ), upper limit of quantitation (ULQ), and precision were determined using serial dilutions of HIV-1 Virology Quality Assurance stock (VQA Rush University), or HIV-1-containing armored RNA, made in venous blood. To evaluate correlation, bias, and agreement, 497 HIV-1 positive adult clinical samples were collected from Ivory Coast, Uganda and South Africa. For each HIV-1 participant, DBS-fingerprick, DBS-venous and plasma sample results were compared. Correlation and bias values were obtained. The sensitivity and specificity were analyzed at a threshold of 1000 HIV-1 copies/mL generated using the standard plasma protocol. The Abbott HIV-1 DBS protocol had an LOD of 839 copies/mL, a linear range from 500 to 1×10(7) copies/mL, an LLQ of 839 copies/mL, a ULQ of 1×10(7) copies/mL, and an inter-assay SD of ≤0.30 log copies/mL for all tested levels within this range. With clinical samples, the correlation coefficient (r value) was 0.896 between DBS-fingerprick and plasma and 0.901 between DBS-venous and plasma, and the bias was -0.07 log copies/mL between DBS-fingerprick and plasma and -0.02 log copies/mL between DBS-venous and plasma. The sensitivity of DBS-fingerprick and DBS-venous was 93%, while the specificity of both DBS methods was 95%. The results demonstrated that the Abbott RealTime HIV-1 assay with DBS sample protocol is highly sensitive, specific and precise across a wide dynamic range and correlates well with plasma values. The Abbott RealTime HIV-1 assay with DBS sample protocol provides an

  17. Genetic characterization of interleukins (IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs

    PubMed Central

    Neves, Fabiana; Abrantes, Joana; Almeida, Tereza; de Matos, Ana Lemos; Costa, Paulo P

    2015-01-01

    ILs, as essential innate immune modulators, are involved in an array of biological processes. In the European rabbit (Oryctolagus cuniculus) IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18 have been implicated in inflammatory processes and in the immune response against rabbit hemorrhagic disease virus and myxoma virus infections. In this study we characterized these ILs in six Lagomorpha species (European rabbit, pygmy rabbit, two cottontail rabbit species, European brown hare and American pika). Overall, these ILs are conserved between lagomorphs, including in their exon/intron structure. Most differences were observed between leporids and American pika. Indeed, when comparing both, some relevant differences were observed in American pika, such as the location of the stop codon in IL-1α and IL-2, the existence of a different transcript in IL8 and the number of cysteine residues in IL-1β. Changes at N-glycosylation motifs were also detected in IL-1, IL-10, IL-12B and IL-15. IL-1α is the protein that presents the highest evolutionary distances, which is in contrast to IL-12A where the distances between lagomorphs are the lowest. For all these ILs, sequences of human and European rabbit are more closely related than between human and mouse or European rabbit and mouse. PMID:26395994

  18. Genetic characterization of interleukins (IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs.

    PubMed

    Neves, Fabiana; Abrantes, Joana; Almeida, Tereza; de Matos, Ana Lemos; Costa, Paulo P; Esteves, Pedro J

    2015-11-01

    ILs, as essential innate immune modulators, are involved in an array of biological processes. In the European rabbit (Oryctolagus cuniculus) IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18 have been implicated in inflammatory processes and in the immune response against rabbit hemorrhagic disease virus and myxoma virus infections. In this study we characterized these ILs in six Lagomorpha species (European rabbit, pygmy rabbit, two cottontail rabbit species, European brown hare and American pika). Overall, these ILs are conserved between lagomorphs, including in their exon/intron structure. Most differences were observed between leporids and American pika. Indeed, when comparing both, some relevant differences were observed in American pika, such as the location of the stop codon in IL-1α and IL-2, the existence of a different transcript in IL8 and the number of cysteine residues in IL-1β. Changes at N-glycosylation motifs were also detected in IL-1, IL-10, IL-12B and IL-15. IL-1α is the protein that presents the highest evolutionary distances, which is in contrast to IL-12A where the distances between lagomorphs are the lowest. For all these ILs, sequences of human and European rabbit are more closely related than between human and mouse or European rabbit and mouse. © The Author(s) 2015.

  19. 77 FR 39508 - Notice of Inventory Completion: Field Museum of Natural History, Chicago, IL; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-03

    ... National Park Service Notice of Inventory Completion: Field Museum of Natural History, Chicago, IL... Museum of Natural History in Chicago, IL (Field Museum). The human remains and associated funerary..., Chicago, IL, 60605-2496, telephone (312) 665-7317, before August 2, 2012. Repatriation of the human...

  20. Hook effect in Abbott i-STAT β-human chorionic gonadotropin (β-hCG) point of care assay.

    PubMed

    Wilgen, Urs; Pretorius, Carel J; Gous, Rehna S; Martin, Cameron; Hale, Vincent J; Ungerer, Jacobus P J

    2014-09-01

    Point-of-care testing for β-hCG has been widely advocated to allow rapid diagnosis/exclusion of pregnancy in the emergency department. A quantitative blood β-hCG assay has the additional benefit of being able to monitor the viability of pregnancy, using serial measurements, to determine the appropriate expected increase in β-hCG levels over time (e.g. ectopic pregnancy), and aiding in determining if an intrauterine gestational sac should be visible on sonographic imaging. Evaluation of the newly released Abbott i-STAT β-hCG point-of-care assay with the Beckman Coulter β-hCG laboratory assay in use. Whole blood, plasma and serum samples with a wide range of β-hCG concentrations were analysed by both methods. The Abbott I-STAT β-hCG compares favourably, can be performed on heparinised whole blood, plasma and serum, and shows acceptable accuracy and precision. However a hook effect at elevated β-hCG was shown in gestational trophoblastic disease as well as normal pregnancies. The i-STAT β-hCG performs acceptably in its intended use in the early detection of pregnancy, but results should always be interpreted within the clinical context, as a hook effect may occur. Crown Copyright © 2014. Published by Elsevier Inc. All rights reserved.

  1. Analytical and clinical performance of Abbott RealTime MTB, an assay for detection of Mycobacterium tuberculosis in pulmonary specimens.

    PubMed

    Tang, Ning; Frank, Andrea; Pahalawatta, Vihanga; Lampinen, John; Coblenz-Korte, Anke; Dunn, Chad; Li, Cheng; Cloherty, Gavin; Abravaya, Klara; Leckie, Gregor

    2015-09-01

    Nucleic acid amplification test (NAAT)-based assays provide fast and sensitive results compared to conventional TB tests. The performance of the new Abbott Molecular MTB assay for the qualitative detection of MTB complex using the automated m2000™ system or manual sample preparation is summarized in this paper. The assay detects eight MTB complex subspecies. The observed limit of detection (LOD) when used to test an MTB H37Rv panel was 2.45 colony forming units (cfu)/mL, while the claimed assay LOD with this MTB strain is 17 cfu/mL. No cross reactivity, or carryover were observed in the study. The clinical sensitivity of the assay was 93% overall; 99% in smear positive, culture positive specimens, and 81% in smear negative, culture positive samples. The clinical specificity was 97%. The inhibition rate in the study was 0.34%. The data suggest that Abbott RealTime MTB is a reliable, robust and sensitive assay for the molecular detection of MTB. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  2. Performance evaluation of the Abbott CELL-DYN Ruby and the Sysmex XT-2000i haematology analysers.

    PubMed

    Leers, M P G; Goertz, H; Feller, A; Hoffmann, J J M L

    2011-02-01

    Two mid-range haematology analysers (Abbott CELL-DYN Ruby and Sysmex XT-2000i) were evaluated to determine their analytical performance and workflow efficiency in the haematology laboratory. In total 418 samples were processed for determining equivalence of complete blood count (CBC) measurements, and 100 for reticulocyte comparison. Blood smears served for assessing the agreement of the differential counts. Inter-instrument agreement for most parameters was good although small numbers of discrepancies were observed. Systematic biases were found for mean cell volume, reticulocytes, platelets and mean platelet volume. CELL-DYN Ruby WBC differentials were obtained with all samples while the XT-2000i suppressed differentials partially or completely in 13 samples (3.1%). WBC subpopulation counts were otherwise in good agreement with no major outliers. Following first-pass CBC/differential analysis, 88 (21%) of XT-2000i samples required further analyser processing compared to 18 (4.3%) for the CELL-DYN Ruby. Smear referrals for suspected WBC/nucleated red blood cells and platelet abnormalities were indicated for 106 (25.4%) and 95 (22.7%) of the XT-2000i and CELL-DYN Ruby samples respectively. Flagging efficiencies for both analysers were found to be similar. The Sysmex XT-2000i and Abbott CELL-DYN Ruby analysers have broadly comparable analytical performance, but the CELL-DYN Ruby showed superior first-pass efficiency. © 2010 Blackwell Publishing Ltd.

  3. Parks In Partnership.

    ERIC Educational Resources Information Center

    Bowman, Sally-Jo

    1998-01-01

    More than 50 National Park Service (NPS) sites interpret Native cultures or early Native contact with Europeans. In about 30 of those, American Indians, Alaska Natives, or Native Hawaiians, in partnership with the NPS, present their own heritage and issues. Describes Native-run aspects of Sitka National Historical Park, Glacier National Park, and…

  4. Interview with Steve Parks

    ERIC Educational Resources Information Center

    Hitchcock, Jennifer

    2016-01-01

    Jennifer Hitchcock interviews community activist and director of Syracuse University's Composition and Cultural Rhetoric doctoral program, Steve Parks. They discuss Parks's working-class background, career path, influences, and activism. Parks also considers the direction of the field of composition and rhetoric and expresses optimism for the…

  5. Parks In Partnership.

    ERIC Educational Resources Information Center

    Bowman, Sally-Jo

    1998-01-01

    More than 50 National Park Service (NPS) sites interpret Native cultures or early Native contact with Europeans. In about 30 of those, American Indians, Alaska Natives, or Native Hawaiians, in partnership with the NPS, present their own heritage and issues. Describes Native-run aspects of Sitka National Historical Park, Glacier National Park, and…

  6. Comparison of Perceptions of "Preparedness" of John Abbott C.E.G.E.P. Nursing Graduates: Prior to Graduation and After.

    ERIC Educational Resources Information Center

    Iton, Carmen; Sabiston, Judy

    A study of John Abbott College's nursing graduates was conducted to determine how well prepared for their professional responsibilities the graduates saw themselves just prior to graduation and later after working in the nursing field. A sample of 98 nursing students who graduated between 1986 and 1988 was surveyed, with 93% responding to the…

  7. [Analytical performances of real-time PCR by Abbott RealTime CMV with m2000 for the detection of cytomegalovirus in urine].

    PubMed

    De Monte, Anne; Cannavo, Isabelle; Caramella, Anne; Ollier, Laurence; Giordanengo, Valérie

    2016-01-01

    Congenital cytomegalovirus (CMV) infection is the leading cause of sensoneurinal disability due to infectious congenital disease. The diagnosis of congenital CMV infection is based on the search of CMV in the urine within the first two weeks of life. Viral culture of urine is the gold standard. However, the PCR is highly sensitive and faster. It is becoming an alternative choice. The objective of this study is the validation of real-time PCR by Abbott RealTime CMV with m2000 for the detection of cytomegalovirus in urine. Repeatability, reproducibility, detection limit and inter-sample contamination were evaluated. Urine samples from patients (n=141) were collected and analyzed simultaneously in culture and PCR in order to assess the correlation of these two methods. The sensitivity and specificity of PCR were also calculated. The Abbott RealTime CMV PCR in urine is an automated and sensitive method (detection limit 200 UI/mL). Fidelity is very good (standard deviation of repeatability: 0.08 to 0.15 LogUI/mL and reproducibility 0.18 LogUI/mL). We can note a good correlation between culture and Abbott RealTime CMV PCR (kappa 96%). When considering rapid culture as reference, real-time PCR was highly sensitive (100%) and specific (98.2%). The real-time PCR by Abbott RealTime CMV with m2000 is optimal for CMV detection in urine.

  8. Industrywide studies report: a walk through survey of Ross Laboratories (Division of Abbott Laboratories), Columbus, Ohio. [Ethylene oxide

    SciTech Connect

    Greife, A.; Steenland, K.

    1985-10-02

    A walk-through survey was conducted at Ross Laboratories, a Division of Abbott Laboratories, Columbus, Ohio in August, 1985. The purpose of the survey was to determine the feasibility of including the facility in a NIOSH industry wide mortality/industrial hygiene survey of ethylene oxide. The facility produced infant formula and infant related products, including nipples. The company had a full time nurse on the first and second shifts. A physician was available on a contract basis. New employees were given preemployment physicals. Employees received annual physicals until 1982 after which they became optional. The physicals did not include any components relating to ethylene-oxide exposure. The authors conclude that the personnel records are not adequate to identify a cohort of exposed individuals at the facility. The facility will not be included in the NIOSH study.

  9. The Abbott Architect c8000: analytical performance and productivity characteristics of a new analyzer applied to general chemistry testing.

    PubMed

    Pauli, Daniela; Seyfarth, Michael; Dibbelt, Leif

    2005-01-01

    Applying basic potentiometric and photometric assays, we evaluated the fully automated random access chemistry analyzer Architect c8000, a new member of the Abbott Architect system family, with respect to both its analytical and operational performance and compared it to an established high-throughput chemistry platform, the Abbott Aeroset. Our results demonstrate that intra- and inter-assay imprecision, inaccuracy, lower limit of detection and linear range of the c8000 generally meet actual requirements of laboratory diagnosis; there were only rare exceptions, e.g. assays for plasma lipase or urine uric acid which apparently need to be improved by additional rinsing of reagent pipettors. Even with plasma exhibiting CK activities as high as 40.000 U/l, sample carryover by the c8000 could not be detected. Comparison of methods run on the c8000 and the Aeroset revealed correlation coefficients of 0.98-1.00; if identical chemistries were applied on both analyzers, slopes of regression lines approached unity. With typical laboratory workloads including 10-20% STAT samples and up to 10% samples with high analyte concentrations demanding dilutional reruns, steady-state throughput numbers of 700 to 800 tests per hour were obtained with the c8000. The system generally responded to STAT orders within 2 minutes yielding analytical STAT order completion times of 5 to 15 minutes depending on the type and number of assays requested per sample. Due to its extended test and sample processing capabilities and highly comfortable software, the c8000 may meet the varying needs of clinical laboratories rather well.

  10. Measurement of immature platelets with Abbott CD-Sapphire and Sysmex XE-5000 in haematology and oncology patients.

    PubMed

    Meintker, Lisa; Haimerl, Maria; Ringwald, Jürgen; Krause, Stefan W

    2013-11-01

    Measurement of immature platelets was introduced into routine diagnostics by Sysmex as immature platelet fraction (IPF) some years ago and recently by Abbott as reticulated platelet fraction (rPT). Here, we compare both methods. We evaluated the precision and agreement of these parameters between Sysmex XE-5000 and Abbott CD-Sapphire in three distinct thrombocytopaenic cohorts: 30 patients with beginning thrombocytopaenia and 64 patients with recovering platelets (PLT) after chemotherapy, 16 patients with immune thrombocytopaenia (ITP) or heparin-induced thrombocytopaenia type 2 (HIT) and 110 additional normal controls. Furthermore, we analysed, how IPF/rPT differed between these thrombocytopaenic cohorts and controls. Both analysers demonstrated acceptable overall precision (repeatability) of IPF/rPT with lower precision at low PLT counts. IPF/rPT artificially increased during storage of blood samples overnight. Inter-instrument comparison showed a moderate correlation (Pearson r²=0.38) and a systematic bias of 1.04 towards higher IPF-values with the XE-5000. IPF/rPT was highest in recovering thrombopoesis after chemotherapy and moderately increased in ITP/HIT. The normal range deduced from control samples was much narrower with CD-Sapphire (1.0%-3.8%, established here for the first time) in comparison to XE-5000 (0.8%-7.9%) leading to a smaller overlap of samples with increased PLT turnover and normal controls. IPF and rPT both give useful information on PLT turnover, although the two analysers only show a moderate inter-instrument correlation and have different reference ranges. A better separation of patient groups with high PLT turnover like ITP/HIT from normal controls is obtained by CD-Sapphire.

  11. Comparison of the Chiron Quantiplex branched DNA (bDNA) assay and the Abbott Genostics solution hybridization assay for quantification of hepatitis B viral DNA.

    PubMed

    Kapke, G E; Watson, G; Sheffler, S; Hunt, D; Frederick, C

    1997-01-01

    Several assays for quantification of DNA have been developed and are currently used in research and clinical laboratories. However, comparison of assay results has been difficult owing to the use of different standards and units of measurements as well as differences between assays in dynamic range and quantification limits. Although a few studies have compared results generated by different assays, there has been no consensus on conversion factors and thorough analysis has been precluded by small sample size and limited dynamic range studied. In this study, we have compared the Chiron branched DNA (bDNA) and Abbott liquid hybridization assays for quantification of hepatitis B virus (HBV) DNA in clinical specimens and have derived conversion factors to facilitate comparison of assay results. Additivity and variance stabilizing (AVAS) regression, a form of non-linear regression analysis, was performed on assay results for specimens from HBV clinical trials. Our results show that there is a strong linear relationship (R2 = 0.96) between log Chiron and log Abbott assay results. Conversion factors derived from regression analyses were found to be non-constant and ranged from 6-40. Analysis of paired assay results below and above each assay's limit of quantification (LOQ) indicated that a significantly (P < 0.01) larger proportion of observations were below the Abbott assay LOQ but above the Chiron assay LOQ, indicating that the Chiron assay is significantly more sensitive than the Abbott assay. Testing of replicate specimens showed that the Chiron assay consistently yielded lower per cent coefficients of variance (% CVs) than the Abbott assay, indicating that the Chiron assay provides superior precision.

  12. Quantitation of estrogen receptor in seventy-five specimens of breast cancer: comparison between an immunoassay (Abbott ER-EIA monoclonal) and a (3H)estradiol binding assay based on isoelectric focusing in polyacrylamide gel

    SciTech Connect

    Pousette, A.; Gustafsson, S.A.; Thoernblad, A.M.N.; Nordgren, A.; Saellstroem, J.Li.; Lindgren, A.; Sundelin, P.; Gustafsson, J.A.

    1986-08-01

    Quantitation of estrogen receptor has been performed in cytosol prepared from 75 specimens of breast cancer tissue from patients who had not received hormonal therapy. The study was performed in order to compare an immunoassay (Abbott Laboratories, North Chicago, IL) with our currently used method for estrogen receptor analysis based on isoelectric focusing of (/sup 3/H)estradiol-receptor complex in polyacrylamide gels. Using linear regression analysis, a regression coefficient (slope) of 1.30 and a correlation coefficient of 0.75 were calculated. The differences in results between the two methods are probably partly explained by the fact that the ligand-based method only measures unoccupied receptor, whereas the immunoassay detects the total amount of receptor, resulting in generally slightly higher concentrations with the latter method. However, in five of 75 specimens the ligand-based method gave a considerably higher concentration of estrogen receptor. This was most probably explained by partial proteolysis resulting in the formation of receptor fragment(s), which was undetectable with the immunoassay but detectable with the ligand-based method. These observations underline the importance of careful handling of specimens during the whole immunoassay procedure.

  13. National parks: Chapter 4

    USGS Publications Warehouse

    Baron, Jill S.; Allen, Craig D.; Fleishman, Erica; Gunderson, Lance; McKenzie, Don; Meyerson, Laura A.; Oropeza, Jill; Stephenson, Nathan L.

    2008-01-01

    Covering about 4% of the United States, the 338,000 km² of protected areas in the National Park System contain representative landscapes of all of the nation’s biomes and ecosystems. The U.S. National Park Service Organic Act established the National Park System in 1916 “to conserve the scenery and the natural and historic objects and the wild life therein and to provide for the enjoyment of the same in such manner and by such means as will leave them unimpaired for the enjoyment of future generations.”1 Approximately 270 national park system areas contain significant natural resources. Current National Park Service policy for natural resource parks calls for management to preserve fundamental physical and biological processes, as well as individual species, features, and plant and animal communities. Parks with managed natural resources range from large intact (or nearly intact) ecosystems with a full complement of native species— including top predators—to those diminished by disturbances such as within-park or surrounding-area legacies of land use, invasive species, pollution, or regional manipulation of resources. The significance of national parks as representatives of naturally functioning ecosystems and as refugia for natural processes and biodiversity increases as surrounding landscapes become increasingly altered by human activities.

  14. Parks, Recreation and Public Health.

    ERIC Educational Resources Information Center

    Ho, Ching-Hua; Payne, Laura; Orsega-Smith, Elizabeth; Godbey, Geoffrey

    2003-01-01

    Reviews what current research says about the holistic health benefits of park and recreation services, focusing on: health benefits according to park users; physical activities in parks; stress reduction benefits of park use; social support, self-determination, and stress reduction; observing nature in parks and associated benefits; and the…

  15. Parks, Recreation and Public Health.

    ERIC Educational Resources Information Center

    Ho, Ching-Hua; Payne, Laura; Orsega-Smith, Elizabeth; Godbey, Geoffrey

    2003-01-01

    Reviews what current research says about the holistic health benefits of park and recreation services, focusing on: health benefits according to park users; physical activities in parks; stress reduction benefits of park use; social support, self-determination, and stress reduction; observing nature in parks and associated benefits; and the…

  16. Interleukins IL-6, IL-8, IL-10, IL-12 and periimplant disease. An update.

    PubMed

    Candel-Martí, Maria-Eugenia; Flichy-Fernández, Antonio-Juan; Alegre-Domingo, Teresa; Ata-Ali, Javier; Peñarrocha-Diago, Maria A

    2011-07-01

    A study is made of the usefulness of cytokines (such as interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10) and interleukin-12 (IL-12)) as markers of periimplant disease (mucositis and periimplantitis). An increase in the levels of these cytokines in dental implant crevicular fluid may give rise to a lack of osteointegration, bone loss or implant failure. To review the literature relating IL-6, IL-8, IL-10 and IL-12 levels to dental implant surgery and periimplantitis. A PubMed literature search was made of articles in English and Spanish, using the key words "cytokine and dental implants", cytokine and periimplantitis", "IL-6, IL-8, IL-10, IL-12 and dental implants", "IL-6, IL-8, IL-10, IL-12 and periimplantitis". Fourteen articles were found and classified into two groups relating interleukin levels to: a) periimplant disease; and b) their influence upon dental implant osteointegration without periimplant disease. An increase in interleukin levels is observed in patients with periimplant disease, though there is controversy over the effect of interleukins in crevicular fluid and periimplantitis in relation to implant failure or the development of periimplant disease.

  17. Field evaluation of Abbott Real Time HIV-1 Qualitative test for early infant diagnosis using dried blood spots samples in comparison to Roche COBAS Ampliprep/COBAS TaqMan HIV-1 Qual test in Kenya.

    PubMed

    Chang, Joy; Omuomo, Kenneth; Anyango, Emily; Kingwara, Leonard; Basiye, Frank; Morwabe, Alex; Shanmugam, Vedapuri; Nguyen, Shon; Sabatier, Jennifer; Zeh, Clement; Ellenberger, Dennis

    2014-08-01

    Timely diagnosis and treatment of infants infected with HIV are critical for reducing infant mortality. High-throughput automated diagnostic tests like Roche COBAS AmpliPrep/COBAS TaqMan HIV-1 Qual Test (Roche CAPCTM Qual) and the Abbott Real Time HIV-1 Qualitative (Abbott Qualitative) can be used to rapidly expand early infant diagnosis testing services. In this study, the performance characteristics of the Abbott Qualitative were evaluated using two hundred dried blood spots (DBS) samples (100 HIV-1 positive and 100 HIV-1 negative) collected from infants attending the antenatal facilities in Kisumu, Kenya. The Abbott Qualitative results were compared to the diagnostic testing completed using the Roche CAPCTM Qual in Kenya. The sensitivity and specificity of the Abbott Qualitative were 99.0% (95% CI: 95.0-100.0) and 100.0% (95% CI: 96.0-100.0), respectively, and the overall reproducibility was 98.0% (95% CI: 86.0-100.0). The limits of detection for the Abbott Qualitative and Roche CAPCTM Qual were 56.5 and 6.9copies/mL at 95% CIs (p=0.005), respectively. The study findings demonstrate that the Abbott Qualitative test is a practical option for timely diagnosis of HIV in infants.

  18. Field evaluation of Abbott Real Time HIV-1 Qualitative test for early infant diagnosis using dried blood spots samples in comparison to Roche COBAS Ampliprep/COBAS TaqMan HIV-1 Qual Test in Kenya

    PubMed Central

    Chang, Joy; Omuomo, Kenneth; Anyango, Emily; Kingwara, Leonard; Basiye, Frank; Morwabe, Alex; Shanmugam, Vedapuri; Nguyen, Shon; Sabatier, Jennifer; Zeh, Clement; Ellenberger, Dennis

    2016-01-01

    Timely diagnosis and treatment of infants infected with HIV are critical for reducing infant mortality. High-throughput automated diagnostic tests like Roche COBAS AmpliPrep/COBAS TaqMan HIV-1 Qual Test (Roche CAPCTM Qual) and the Abbott Real Time HIV-1 Qualitative (Abbott Qualitative) can be used to rapidly expand early infant diagnosis testing services. In this study, the performance characteristics of the Abbott Qualitative were evaluated using two hundred dried blood spots (DBS) samples (100 HIV-1 positive and 100 HIV-1 negative) collected from infants attending the antenatal facilities in Kisumu, Kenya. The Abbott Qualitative results were compared to the diagnostic testing completed using the Roche CAPCTM Qual in Kenya. The sensitivity and specificity of the Abbott Qualitative were 99.0% (95% CI: 95.0–100.0) and 100.0% (95% CI: 96.0–100.0), respectively, and the overall reproducibility was 98.0% (95% CI: 86.0–100.0). The limits of detection for the Abbott Qualitative and Roche CAPCTM Qual were 56.5 and 6.9 copies/mL at 95% CIs (p = 0.005), respectively. The study findings demonstrate that the Abbott Qualitative test is a practical option for timely diagnosis of HIV in infants. PMID:24726703

  19. "Rocket Park" - exhibits

    NASA Image and Video Library

    1979-12-20

    Overall view at JSC lookin west from atop of Bldg. 1 showing rockets, parking lot and all threee stages of Saturn V. first stage of Saturn V exhibit in "Rocket Park" on west side of center little joe and mercury models are seen 1. JSC- Aerials

  20. Preserving DOE's Research Parks.

    ERIC Educational Resources Information Center

    Dale, Virginia H.; Parr, Patricia D.

    1998-01-01

    Seven sites are designated as Department of Energy (DOE) National Environmental Research Parks and serve as irreplaceable outdoor laboratories for scientific research and education. The DOE has recommended the disposal of nearly one- quarter of the research park land holdings. Offers suggestions for developing a plan for protecting the…

  1. Oregon's first wind park

    SciTech Connect

    Not Available

    1984-01-01

    The bringing on-line of the 1.25 MW wind park at Whiskey Run, Oregon, is reported. The park features twenty-five 50 KW wind turbine generators and is expected to produce about three million kilowatt-hours per year for the Pacific Power and Light system.

  2. Splendor In The Parks.

    ERIC Educational Resources Information Center

    Smith, Anthony Wayne

    1979-01-01

    Civilization is more and more intruding on the esthetic and recreational resources of the National Park System. Increased attention must be paid to controlling noise, pollution, and even the effects of urban lighting which detract from the enjoyment of the parks. (RE)

  3. Splendor In The Parks.

    ERIC Educational Resources Information Center

    Smith, Anthony Wayne

    1979-01-01

    Civilization is more and more intruding on the esthetic and recreational resources of the National Park System. Increased attention must be paid to controlling noise, pollution, and even the effects of urban lighting which detract from the enjoyment of the parks. (RE)

  4. Urban park tree inventories

    Treesearch

    Joe R. McBride; David J. Nowak

    1989-01-01

    A survey of published reports on urban park tree inventories in the United States and the United Kingdom reveal two types of inventories: (1) Tree Location Inventories and (2) Generalized Information Inventories. Tree location inventories permit managers to relocate specific park trees, along with providing individual tree characteristics and condition data. In...

  5. Acadia National Park

    NASA Image and Video Library

    2017-09-28

    Acadia National Park is one of the most visited parks in America, drawing more than 2.5 million visitors per year to the craggy, jagged coast of Maine. The park is celebrating its 100th anniversary in 2016. On September 6, 2015, the Operational Land Imager (OLI) on the Landsat 8 satellite acquired these images of Acadia National Park and its surroundings. Mountains and hills roll right up to the Atlantic Ocean in this rocky landscape carved by glaciers at the end of the last Ice Age. Since the beginning of the 20th Century, the park has been pieced together by donations and acquisitions of once-private lands, and it is still growing. Of the park’s 47,000 acres, more than 12,000 are privately owned lands under conservation agreements, while the rest is held by the National Park Service. Mount Desert Island is the focal point of the park, which also includes lands around a former naval base (Schoodic Peninsula), Isle au Haut, and several smaller islands. Read more: go.nasa.gov/2adyd8J Credit: NASA/Landsat8 NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

  6. Sequoia National Park

    NASA Image and Video Library

    2017-09-28

    Naked peaks, sheltered valleys, snowfields, towering trees, and alpine meadows make up the varied landscape of Sequoia National Park in California. Established as a National Park by Congress on September 25, 1890, Sequoia National Park is the second-oldest U.S. National Park, after Yellowstone. This national park borders Kings Canyon National Park. The Thematic Mapper sensor on NASA’s Landsat 5 satellite captured this true-color image of Sequoia National Park, outlined in white, on October 22, 2008. Sunlight illuminates southern slopes, leaving northern faces in shadow in this autumn image. In the west, deep green conifers carpet most of the land. These forested mountains are home to the park’s most famous giant sequoia trees. Sequoia National Park sits at the southern end of the Sierra Nevada mountains. Terrain alternates between extremes, from peaks such as Mt. Whitney—the highest peak in the contiguous United States—to deep caverns. The rivers and lakes in this region are part of a watershed valuable not only to the plants and animals of the park, but also to farms and cities in California’s Central Valley. Read more: go.nasa.gov/2bzGOXr Credit: NASA/Landsat5 NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

  7. Performance evaluation of the QIAGEN EZ1 DSP Virus Kit with Abbott RealTime HIV-1, HBV and HCV assays.

    PubMed

    Schneider, George J; Kuper, Kevin G; Abravaya, Klara; Mullen, Carolyn R; Schmidt, Marion; Bunse-Grassmann, Astrid; Sprenger-Haussels, Markus

    2009-04-01

    Automated sample preparation systems must meet the demands of routine diagnostics laboratories with regard to performance characteristics and compatibility with downstream assays. In this study, the performance of QIAGEN EZ1 DSP Virus Kit on the BioRobot EZ1 DSP was evaluated in combination with the Abbott RealTime HIV-1, HCV, and HBV assays, followed by thermalcycling and detection on the Abbott m2000rt platform. The following performance characteristics were evaluated: linear range and precision, sensitivity, cross-contamination, effects of interfering substances and correlation. Linearity was observed within the tested ranges (for HIV-1: 2.0-6.0 log copies/ml, HCV: 1.3-6.9 log IU/ml, HBV: 1.6-7.6 log copies/ml). Excellent precision was obtained (inter-assay standard deviation for HIV-1: 0.06-0.17 log copies/ml (>2.17 log copies/ml), HCV: 0.05-0.11 log IU/ml (>2.09 log IU/ml), HBV: 0.03-0.07 log copies/ml (>2.55 log copies/ml)), with good sensitivity (95% hit rates for HIV-1: 50 copies/ml, HCV: 12.5 IU/ml, HBV: 10 IU/ml). No cross-contamination was observed, as well as no negative impact of elevated levels of various interfering substances. In addition, HCV and HBV viral load measurements after BioRobot EZ1 DSP extraction correlated well with those obtained after Abbott m2000sp extraction. This evaluation demonstrates that the QIAGEN EZ1 DSP Virus Kit provides an attractive solution for fully automated, low throughput sample preparation for use with the Abbott RealTime HIV-1, HCV, and HBV assays.

  8. Fully automated quantification of cytomegalovirus (CMV) in whole blood with the new sensitive Abbott RealTime CMV assay in the era of the CMV international standard.

    PubMed

    Schnepf, Nathalie; Scieux, Catherine; Resche-Riggon, Matthieu; Feghoul, Linda; Xhaard, Alienor; Gallien, Sébastien; Molina, Jean-Michel; Socié, Gérard; Viglietti, Denis; Simon, François; Mazeron, Marie-Christine; Legoff, Jérôme

    2013-07-01

    Fully standardized reproducible and sensitive quantification assays for cytomegalovirus (CMV) are needed to better define thresholds for antiviral therapy initiation and interruption. We evaluated the newly released Abbott RealTime CMV assay for CMV quantification in whole blood (WB) that includes automated extraction and amplification (m2000 RealTime system). Sensitivity, accuracy, linearity, and intra- and interassay variability were validated in a WB matrix using Quality Control for Molecular Diagnostics (QCMD) panels and the WHO international standard (IS). The intra- and interassay coefficients of variation were 1.37% and 2.09% at 5 log10 copies/ml and 2.41% and 3.80% at 3 log10 copies/ml, respectively. According to expected values for the QCMD and Abbott RealTime CMV methods, the lower limits of quantification were 104 and <50 copies/ml, respectively. The conversion factor between international units and copies (2.18), determined from serial dilutions of the WHO IS in WB, was significantly different from the factor provided by the manufacturer (1.56) (P = 0.001). Results from 302 clinical samples were compared with those from the Qiagen artus CMV assay on the same m2000 RealTime system. The two assays provided highly concordant results (concordance correlation coefficient, 0.92), but the Abbott RealTime CMV assay detected and quantified, respectively, 20.6% and 47.8% more samples than the Qiagen/artus CMV assay. The sensitivity and reproducibility of the results, along with the automation, fulfilled the quality requirements for implementation of the Abbott RealTime CMV assay in clinical settings. Our results highlight the need for careful validation of conversion factors provided by the manufacturers for the WHO IS in WB to allow future comparison of results obtained with different assays.

  9. Fully Automated Quantification of Cytomegalovirus (CMV) in Whole Blood with the New Sensitive Abbott RealTime CMV Assay in the Era of the CMV International Standard

    PubMed Central

    Schnepf, Nathalie; Scieux, Catherine; Resche-Riggon, Matthieu; Feghoul, Linda; Xhaard, Alienor; Gallien, Sébastien; Molina, Jean-Michel; Socié, Gérard; Viglietti, Denis; Simon, François; Mazeron, Marie-Christine

    2013-01-01

    Fully standardized reproducible and sensitive quantification assays for cytomegalovirus (CMV) are needed to better define thresholds for antiviral therapy initiation and interruption. We evaluated the newly released Abbott RealTime CMV assay for CMV quantification in whole blood (WB) that includes automated extraction and amplification (m2000 RealTime system). Sensitivity, accuracy, linearity, and intra- and interassay variability were validated in a WB matrix using Quality Control for Molecular Diagnostics (QCMD) panels and the WHO international standard (IS). The intra- and interassay coefficients of variation were 1.37% and 2.09% at 5 log10 copies/ml and 2.41% and 3.80% at 3 log10 copies/ml, respectively. According to expected values for the QCMD and Abbott RealTime CMV methods, the lower limits of quantification were 104 and <50 copies/ml, respectively. The conversion factor between international units and copies (2.18), determined from serial dilutions of the WHO IS in WB, was significantly different from the factor provided by the manufacturer (1.56) (P = 0.001). Results from 302 clinical samples were compared with those from the Qiagen artus CMV assay on the same m2000 RealTime system. The two assays provided highly concordant results (concordance correlation coefficient, 0.92), but the Abbott RealTime CMV assay detected and quantified, respectively, 20.6% and 47.8% more samples than the Qiagen/artus CMV assay. The sensitivity and reproducibility of the results, along with the automation, fulfilled the quality requirements for implementation of the Abbott RealTime CMV assay in clinical settings. Our results highlight the need for careful validation of conversion factors provided by the manufacturers for the WHO IS in WB to allow future comparison of results obtained with different assays. PMID:23616450

  10. Comparison of the clinical performances of the AdvanSure HPV Screening Real-Time PCR, the Abbott Real-Time High-Risk HPV Test, and the Hybrid Capture High-Risk HPV DNA Test for Cervical Cancer Screening.

    PubMed

    Chung, Hae-Sun; Hahm, Chorong; Lee, Miae

    2014-09-01

    The clinical performance of three human papillomavirus (HPV) DNA commercial assays for cervical cancer screening was evaluated; the AdvanSure HPV Screening Real-Time PCR (AdvanSure PCR; LG Life Sciences) that was developed recently for the detection of both high-risk and low-risk genotypes, the Abbott RealTime High-Risk HPV Test (Abbott PCR; Abbott Molecular) and the Hybrid Capture High-Risk HPV DNA test (HC2; Qiagen). The three different HPV DNA tests were compared using cytology samples obtained from 619 women who underwent routine cervical cancer screening. The gold-standard assay was histopathological confirmation of cervical intraepithelial neoplasia of grade 2 or worse. The clinical sensitivities of the AdvanSure PCR, the Abbott PCR and the HC2 for the detection of cervical intraepithelial neoplasia of grade 2 or worse were 95.5%, 95.5% and 100%, respectively, while the clinical specificities were 61.6%, 86.4% and 83.3%, respectively. There were no significant differences in the clinical sensitivities of the Abbott PCR and the AdvanSure PCR compared to the HC2. The clinical specificities of the Abbott PCR and the AdvanSure PCR for the detection of HPV types 16/18 were 97.8% and 98.5%, respectively. For cervical cancer screening, all three tests showed relatively good clinical sensitivities, but the AdvanSure PCR had lower clinical specificity than the Abbott PCR and the HC2. The AdvanSure PCR and the Abbott PCR assays have the advantage of being automated and the ability to distinguish between HPV types 16/18 and other HPV types. The two real-time PCR assays could be useful tools in HPV testing for cervical cancer screening.

  11. An evaluation of the differential from the Abbott CD 3500 in a population of patients with haematological abnormalities.

    PubMed

    Iles-Mann, J; Henniker, J

    1997-09-01

    The Cell Dyn 3500 (CD 3500) Haematology Analyser (Abbott Diagnostics, Lane Cove, NSW, Australia) has been evaluated to determine the reliability of the differential and white cell suspect flagging in a population of patients with known haematological abnormalities. The evaluation included the assessment of white cell differential parameters in addition to sensitivity, specificity and efficiency of white cell suspect flagging. The study showed that the CD 3500 is an efficient and sensitive screening tool for detecting the presence of clinically significant white cell abnormalities. Generally, the Blast and Band flags demonstrated the highest level of false positive flagging (lowest sensitivity). The immature granulocyte flag was found to be an extremely reliable indicator of the presence of myelocytes, metamyelocytes and promyelocytes on the film. There was a 0.4% false negative rate where significant numbers of variant lymphocytes (> 10%) were not detected by the CD 3500 on flagging alone. When analyser flags and white cell scatter distribution are considered in combination with defined laboratory limits, all white cell suspect flags have acceptable sensitivity, specificity and efficiency rates.

  12. IL-17 and infections.

    PubMed

    Ling, Y; Puel, A

    2014-10-01

    IL-17 immunity has been shown to be essential for mucocutaneous protection against Candida albicans in mice and humans. However, mice with defective IL-17 immunity display broader susceptibility, as they are also prone to infections with diverse infectious agents at various sites. Humans with genetic defects affecting their IL-17 immunity usually suffer from chronic mucocutaneous candidiasis (CMC): recurrent or persistent infections of the skin, nails, and mucosae with C. albicans, with or without other clinical signs. Most patients with autosomal dominant (AD) hyper-IgE syndrome (HIES) due to STAT3 deficiency or AD STAT1 gain-of-function display impaired IL-17-producing T-cell development, and CMC is one of their principal clinical manifestations. Similarly, patients with autosomal recessive (AR) autoimmune polyendocrine syndrome type 1 (APS-1) caused by AIRE deficiency have high levels of neutralizing autoantibodies against IL-17A, IL-17F and/or IL-22 and present CMC as their only infectious disease. Finally, CMC is the main clinical phenotype observed in patients with inborn errors specifically affecting IL-17 immunity. Indeed, patients with AD IL-17F deficiency or AR IL-17RA or ACT1 deficiency display CMC and, to a lesser extent, superficial staphylococcal diseases. Candida infection was recently reported in psoriasis patients treated with anti-IL-17A antibodies. Careful monitoring for CMC is thus important during anti-IL-17 treatment.

  13. Master Plans for Park Sites.

    ERIC Educational Resources Information Center

    Van Meter, Jerry R.

    This booklet is a general guide to park site planning. The four basic steps involved in developing a park site are a) determination of the uses of the site, b) analysis of the site potential for these uses, c) identification of the functional relationship among the uses, and d) coordination of the uses to the park sites. Uses of park sites are…

  14. Kruger National Park

    Atmospheric Science Data Center

    2013-04-15

    ... above and to the right of image center is the Palabora Copper Mine, and the water body near upper right is Lake Massingir in ... South Africa showing Kruger Park, the Palabora Copper Mine, and Lake Massingir. project:  MISR ...

  15. NASA IN THE PARK

    NASA Image and Video Library

    2016-06-18

    MORE THAN 7,500 PEOPLE ATTENDED NASA MARSHALL SPACE CENTER AND DOWNTOWN HUNTSVILLE, INC.’S THIRD ANNUAL CELEBRATION OF NASA AND THE COMMUNITY JUNE 18. THIS YEAR, THE EVENT MOVED TO HUNTSVILLE’S BIG SPRING PARK.

  16. High School Parking Lots.

    ERIC Educational Resources Information Center

    Neff, Thomas G.

    2002-01-01

    Describes the reorganization of the site of Ben Davis High School in Wayne Township, Indiana as an example of improvements to school parking lot design and vehicle/pedestrian traffic flow and security. Includes design drawings. (EV)

  17. 75 FR 52022 - Notice of Inventory Completion: Field Museum of Natural History, Chicago, IL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-24

    ... National Park Service Notice of Inventory Completion: Field Museum of Natural History, Chicago, IL AGENCY... History, Chicago, IL. The human remains and associated funerary objects were removed from near or in... History professional staff in consultation with representatives of the Confederated Tribes of the...

  18. 75 FR 45659 - Notice of Inventory Completion: Field Museum of Natural History, Chicago, IL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-03

    ... National Park Service Notice of Inventory Completion: Field Museum of Natural History, Chicago, IL AGENCY... History, Chicago, IL. The human remains and associated funerary objects were removed from various... made by the Field Museum of Natural History professional staff in consultation with representatives...

  19. 75 FR 438 - Notice of Inventory Completion: Field Museum of Natural History, Chicago, IL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-05

    ... Museum of Natural History, Chicago, IL AGENCY: National Park Service, Interior. ACTION: Notice. Notice is... of Natural History, Chicago, IL. The human remains were removed from Howkan, AK. This notice is... made by Field Museum of Natural History professional staff in consultation with representatives of...

  20. 75 FR 5104 - Notice of Inventory Completion: Madison County Historical Society, Edwardsville, IL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-01

    ... National Park Service Notice of Inventory Completion: Madison County Historical Society, Edwardsville, IL... inventory of human remains in the possession of the Madison County Historical Society, Edwardsville, IL. The... made by Madison County Historical Society professional staff in consultation with representatives...

  1. 75 FR 435 - Notice of Inventory Completion: Field Museum of Natural History, Chicago, IL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-05

    ... that removal were purchased by the Field Museum of Natural History from Ward's Natural Science... Museum of Natural History, Chicago, IL AGENCY: National Park Service, Interior. ACTION: Notice. Notice is... of Natural History, Chicago, IL. The human remains were removed from the Channel Islands in Santa...

  2. Biscayne National Park

    NASA Image and Video Library

    2017-09-28

    On February 25, 2016, the Operational Land Imager (OLI) on the Landsat 8 satellite acquired this natural-color image of Biscayne National Park. The park encompasses the northernmost Florida Keys, starting from Miami to just north of Key Largo. The keys run like a spine through the center of the park, with Biscayne Bay to the west and the Atlantic Ocean to the east. The water-covered areas span more than 660 square kilometers (250 square miles) of the park, making it the largest marine park in the U.S. National Park System. Biscayne protects the longest stretch of mangrove forest on the U.S. East Coast, and one of the most extensive stretches of coral reef in the world. Read more: go.nasa.gov/1SWs1a3 Credit: NASA/Landsat8 NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

  3. Impact of park renovations on park use and park-based physical activity.

    PubMed

    Cohen, Deborah A; Han, Bing; Isacoff, Jennifer; Shulaker, Bianca; Williamson, Stephanie; Marsh, Terry; McKenzie, Thomas L; Weir, Megan; Bhatia, Rajiv

    2015-02-01

    Given the concerns about low rates of physical activity among low-income minority youth, many community-based organizations are investing in the creation or renovation of public parks to encourage youth to become more physically active. To what degree park renovations accomplish this goal is not known. We used the System for Observing Play and Recreation in Communities (SOPARC) to measure park users and their physical activity levels before and after 2 parks were renovated. We compared findings with 4 parks: 2 that were unrenovated parks and 2 that were undergoing renovation. We also surveyed park users and local residents about their use of the parks. Compared with parks that had not yet been renovated, the improved parks saw more than a doubling in the number of visitors and a substantial increase in energy expended in the parks. Increased park use was pronounced in adults and children, but was not seen in teens and seniors. Park renovations were associated with a significantly increased perception of park safety. Park improvements can have a significant impact on increasing park use and local physical activity.

  4. Redwood National Park

    NASA Image and Video Library

    2017-09-28

    In 1968, after state parks had already been established in northern California, the U.S. Congress established Redwood National Park. This new park supplemented protected lands in the region, and in 1994, state and federal authorities agreed to jointly manage the area’s public lands. On February 6, 2003, the Enhanced Thamatic Mapper Plus on NASA’s Landsat 7 satellite captured this true-color image of the southern end of Redwood National Park - a thin coastal corridor connects the northern and southern ends of the park system. Along the coast, sandy beaches appear off-white, and sediments form swirls of pale blue in the darker blue sea. Inland, the park is dominated by green vegetation, with isolated patches of gray-beige rock. This image of the Redwood National Park includes two stands of trees: Lady Bird Johnson Grove and Tall Trees Grove. The first grove was dedicated to the former first lady by President Richard Nixon in August 1969. The second grove became the focus of efforts to protect the surrounding area from logging. Two waterways appear in this image: Redwood Creek and Klamath River. The more conspicuous Klamath River flows through the park system’s midsection (north of the area pictured here). Redwood Creek flows through the southern portion of the park system. Both waterways have carved gorges through the mountainous landscape. Redwood National and State Parks occupy an area considered to be the most seismically active in the United States. The frequent seismic activity has led to shifting waterways, landslides, and rapid erosion along the coastline. Read more: go.nasa.gov/2bRlryv Credit: NASA/Landsat7 NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter

  5. Impact of the New Abbott mPLUS Feature on Clinical Laboratory Efficiencies of Abbott RealTime Assays for Detection of HIV-1, Hepatitis C Virus, Hepatitis B Virus, Chlamydia trachomatis, and Neisseria gonorrhoeae

    PubMed Central

    Jones, Sara; Wiesneth, Russ; Barry, Cathy; Webb, Erika; Belova, Larissa; Dolan, Peggy; Ho, Shiaolan; Abravaya, Klara; Cloherty, Gavin

    2013-01-01

    Diagnostic laboratories are under increasing pressure to improve and expand their services. Greater flexibility in sample processing is a critical factor that can improve the time to results while reducing reagent waste, making laboratories more efficient and cost-effective. The introduction of the Abbott mPLUS feature, with the capacity for extended use of amplification reagents, significantly increases the flexibility of the m2000 platform and enables laboratories to customize their workflows based on sample arrival patterns. The flexibility in sample batch size offered by mPLUS enables significant reductions in processing times. For hepatitis B virus tests, a reduction in sample turnaround times of up to 30% (105 min) was observed for batches of 12 samples compared with those for batches of 24 samples; for Chlamydia trachomatis/Neisseria gonorrhoeae tests, the ability to run batches of 24 samples reduced the turnaround time by 83% (54 min) compared with that for batches of 48 samples. Excellent correlations between mPLUS and m2000 standard condition results were observed for all RealTime viral load assays evaluated in this study, with correlation r values of 0.998 for all assays tested. For the qualitative RealTime C. trachomatis/N. gonorrhoeae assay, the overall agreements between the two conditions tested were >98% for C. trachomatis and 100% for N. gonorrhoeae. Comparable precision results were observed for the two conditions tested for all RealTime assays. The enhanced mPLUS capability provides clinical laboratories with increased efficiencies to meet increasingly stringent turnaround time requirements without increased costs associated with discarding partially used amplification reagents. PMID:24088850

  6. Guidelines for Recreation and Park Systems.

    ERIC Educational Resources Information Center

    Bannon, Joseph J.; Storey, Edward H.

    In this publication, written for use in guiding community recreation and park systems, the following topics are discussed: why parks and recreational facilities should be developed, the need for governmental participation, and park-system development. Additionally, neighborhood parks, playlots, community parks, city-wide parks, regional parks and…

  7. Premarket Evaluations of the IMDx C. difficile for Abbott m2000 Assay and the BD Max Cdiff Assay

    PubMed Central

    Espino, A. A.; Maceira, V. P.; Nattanmai, S. M.; Butt, S. A.; Wroblewski, D.; Hannett, G. E.; Musser, K. A.

    2014-01-01

    Clostridium difficile-associated diarrhea is a well-recognized complication of antibiotic use. Historically, diagnosing C. difficile has been difficult, as antigen assays are insensitive and culture-based methods require several days to yield results. Nucleic acid amplification tests (NAATs) are quickly becoming the standard of care. We compared the performance of two automated investigational/research use only (IUO/RUO) NAATs for the detection of C. difficile toxin genes, the IMDx C. difficile for Abbott m2000 Assay (IMDx) and the BD Max Cdiff Assay (Max). A prospective analysis of 111 stool specimens received in the laboratory for C. difficile testing by the laboratory's test of record (TOR), the BD GeneOhm Cdiff Assay, and a retrospective analysis of 88 specimens previously determined to be positive for C. difficile were included in the study. One prospective specimen was excluded due to loss to follow-up discrepancy analysis. Of the remaining 198 specimens, 90 were positive by all three methods, 9 were positive by TOR and Max, and 3 were positive by TOR only. One negative specimen was initially inhibitory by Max. The remaining 95 specimens were negative by all methods. Toxigenic C. difficile culture was performed on the 12 discrepant samples. True C. difficile-positive status was defined as either positive by all three amplification assays or positive by toxigenic culture. Based on this definition, the sensitivity and specificity were 96.9% and 95% for Max and 92.8% and 100% for IMDx. In summary, both highly automated systems demonstrated excellent performance, and each has individual benefits, which will ensure that they will both have a niche in clinical laboratories. PMID:24554744

  8. Evaluation of the semiautomated Abbott LCx Mycobacterium tuberculosis assay for direct detection of Mycobacterium tuberculosis in respiratory specimens.

    PubMed Central

    Ausina, V; Gamboa, F; Gazapo, E; Manterola, J M; Lonca, J; Matas, L; Manzano, J R; Rodrigo, C; Cardona, P J; Padilla, E

    1997-01-01

    Five hundred twenty processed respiratory specimens from 326 patients received for the diagnosis of tuberculosis or other mycobacterial infections were tested by means of the LCx Mycobacterium tuberculosis Assay from Abbott Laboratories, which uses ligase chain reaction technology for the direct detection of M. tuberculosis complex in respiratory specimens. The results of the LCx M. tuberculosis Assay were compared with the results of culture and staining techniques. After a combination of culture results and the patient's clinical data, a total of 195 specimens were collected from 110 patients who were positively diagnosed as having pulmonary tuberculosis. Twenty-three of these 195 specimens which corresponded to 10 patients with a history of pulmonary tuberculosis (TB) and anti-TB treatment ranging from 1 to 6 months were culture negative. The other 172 specimens were culture positive for M. tuberculosis. With an overall positivity rate of 37.5% (195 of 520 specimens), the sensitivity, specificity, and positive and negative predictive values were 90.8, 100, 100, and 94.7%, respectively, for the LCx M. tuberculosis Assay; 88.2, 100, 100, and 93.4%, respectively, for culture; and 82.6, 92, 72.9, and 97.6%, respectively, for acid-fast staining. For 161 specimens (82.6%) from patients smear positive for the disease and 34 specimens (17.4%) from patients smear negative for the disease, the sensitivity values for the LCx M. tuberculosis Assay were 98.8 and 53%, respectively. There were no statistically significant differences in the sensitivities and specificities between the LCx M. tuberculosis Assay and culture (P > 0.05). Conclusively, the LCx M. tuberculosis Assay has proved to have an acceptable sensitivity and a high specificity in detecting M. tuberculosis and has the potential of reducing the diagnosis time to an 8-h working day. PMID:9230369

  9. A next generation enzymatic magnesium assay on the Abbott ARCHITECT chemistry system meets performance goals based on biological variation.

    PubMed

    Bailey, D; Martens, P; Mah, W; Yip, P M

    2014-01-01

    To evaluate the performance of the Abbott ARCHITECT enzymatic assay for magnesium (3P68) in serum/plasma and urine against analytical goals based on biological variation. Analytical performance was evaluated according to CLSI protocols. Precision was examined using commercial chemistry controls. Accuracy was assessed against NIST SRM 956c, electrolytes in human serum. Correlation with the arsenazo Mg assay (7D70) was completed using patient samples (plasma, N = 101; urine, N = 90). Common interferences were examined in pooled patient specimens with high and low magnesium concentrations. The enzymatic Mg assay displayed imprecision of 1.7% at 0.72 mmol/L and 1.4% at 1.80 mmol/L (20 days, one calibration, one reagent lot). The linear range was verified between 0.18-7.0 mmol/L (plasma) and 0.01-10.69 mmol/L (urine). Results of the enzymatic assay (x) correlated well with the predicate assay (y) with the relationships y = 0.891x + 0.035, R = 0.967 (plasma) and y = 1.181x + 0.086, R = 0.997 (urine). Mean bias of the NIST SRM 956 c samples was -1.4%. This method showed minimal interference by hemoglobin (3g/L as hemolysate), lipemia (20 g/L Intralipid), unconjugated bilirubin (531 μmol/L), and ascorbate (680 μmol/L). The ARCHITECT Magnesium assay 3P68 achieved the desirable analytical quality specification of 4.8% for total allowable error. In comparison to the 7D70 assay, notable improvements are seen in precision, 30-day calibration stability, and minimal interference by hemolyzed and lipemic samples. © 2013.

  10. Premarket evaluations of the IMDx C. difficile for Abbott m2000 Assay and the BD Max Cdiff Assay.

    PubMed

    Stellrecht, K A; Espino, A A; Maceira, V P; Nattanmai, S M; Butt, S A; Wroblewski, D; Hannett, G E; Musser, K A

    2014-05-01

    Clostridium difficile-associated diarrhea is a well-recognized complication of antibiotic use. Historically, diagnosing C. difficile has been difficult, as antigen assays are insensitive and culture-based methods require several days to yield results. Nucleic acid amplification tests (NAATs) are quickly becoming the standard of care. We compared the performance of two automated investigational/research use only (IUO/RUO) NAATs for the detection of C. difficile toxin genes, the IMDx C. difficile for Abbott m2000 Assay (IMDx) and the BD Max Cdiff Assay (Max). A prospective analysis of 111 stool specimens received in the laboratory for C. difficile testing by the laboratory's test of record (TOR), the BD GeneOhm Cdiff Assay, and a retrospective analysis of 88 specimens previously determined to be positive for C. difficile were included in the study. One prospective specimen was excluded due to loss to follow-up discrepancy analysis. Of the remaining 198 specimens, 90 were positive by all three methods, 9 were positive by TOR and Max, and 3 were positive by TOR only. One negative specimen was initially inhibitory by Max. The remaining 95 specimens were negative by all methods. Toxigenic C. difficile culture was performed on the 12 discrepant samples. True C. difficile-positive status was defined as either positive by all three amplification assays or positive by toxigenic culture. Based on this definition, the sensitivity and specificity were 96.9% and 95% for Max and 92.8% and 100% for IMDx. In summary, both highly automated systems demonstrated excellent performance, and each has individual benefits, which will ensure that they will both have a niche in clinical laboratories.

  11. Il problema del litio.

    NASA Astrophysics Data System (ADS)

    D'Antona, F.

    1995-03-01

    Contents: 1. Introduzione. 2. La nucleosintesi del Big Bang. 3. Il litio nelle stelle di popolazione II. 4. I modelli stellari standard. 5. Il litio negli ammassi aperti. 6. Meccanismi di distruzione "non standard". 7. I modelli non-standard applicati alla popolazione II. 8. L'evoluzione Galattica del litio. 9. Quali stelle producono litio? 10. Il litio come elemento chiave per dare un nome agli oggetti stellari più minuscoli. 11. Conclusioni.

  12. Geology of National Parks

    USGS Publications Warehouse

    Stoffer, Philip W.

    2008-01-01

    This is a set of two sheets of 3D images showing geologic features of many National Parks. Red-and-cyan viewing glasses are need to see the three-dimensional effect. A search on the World Wide Web will yield many sites about anaglyphs and where to get 3D glasses. Red-blue glasses will do but red-cyan glasses are a little better. This publication features a photo quiz game: Name that park! where you can explore, interpret, and identify selected park landscapes. Can you identify landscape features in the images? Can you explain processes that may have helped form the landscape features? You can get the answers online.

  13. FACING NORTHEAST OF NORTHERN BOUNDARY OF PARK Candler Park ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    FACING NORTHEAST OF NORTHERN BOUNDARY OF PARK - Candler Park Historic District, Roughly bounded by Moreland, Dekalb, McLendon & Harold Avenues, Matthews Street & Clifton Terrace, Atlanta, Fulton County, GA

  14. FACING NORTHWEST TOWARD NORTHERN END OF PARK Candler Park ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    FACING NORTHWEST TOWARD NORTHERN END OF PARK - Candler Park Historic District, Roughly bounded by Moreland, Dekalb, McLendon & Harold Avenues, Matthews Street & Clifton Terrace, Atlanta, Fulton County, GA

  15. The Central Park Workbook. Activities for an Urban Park.

    ERIC Educational Resources Information Center

    Finkelstein, Robert J.

    This workbook contains many outdoor activities which were developed in New York's Central Park to help children explore and understand their city parks. Involvement in the activities is intended to increase appreciation and awareness of the role of parks in the urban environment. The publication can serve as an example of what others can do with…

  16. IL-17RD (Sef or IL-17RLM) interacts with IL-17 receptor and mediates IL-17 signaling

    PubMed Central

    Rong, Zhili; Wang, Anan; Li, Zhiyong; Ren, Yongming; Cheng, Long; Li, Yinghua; Wang, Yinyin; Ren, Fangli; Zhang, Xiaoning; Hu, Jim; Chang, Zhijie

    2015-01-01

    Interleukin-17 (IL-17 or IL-17A) production is a hallmark of TH17 cells, a new unique lineage of CD4+ T lymphocytes contributing to the pathogenesis of multiple autoimmune and inflammatory diseases. IL-17 receptor (IL-17R or IL-17RA) is essential for IL-17 biological activity. Emerging data suggest that the formation of a heteromeric and/or homomeric receptor complex is required for IL-17 signaling. Here we show that the orphan receptor IL-17RD (Sef, similar expression to FGF genes or IL-17RLM) is associated and colocalized with IL-17R. Importantly, IL-17RD mediates IL-17 signaling, as evaluated using a luciferase reporter driven by the native promoter of 24p3, an IL-17 target gene. In addition, an IL-17RD mutant lacking the intracellular domain dominant-negatively suppresses IL-17R-mediated IL-17 signaling. Moreover, IL-17RD as well as IL-17R is associated with TRAF6, an IL-17R downstream molecule. These results indicate that IL-17RD is a part of the IL-17 receptor signaling complex, therefore providing novel evidence for IL-17 signaling through a heteromeric and/or homomeric receptor complex. PMID:19079364

  17. Parking Structures and the Space Race.

    ERIC Educational Resources Information Center

    Milshtein, Amy

    2000-01-01

    Presents some solutions to overcrowded parking on college campuses. Tips on selecting sites for parking garages, making parking decks blend with adjacent communities, and turning parking garages into multi use facilities are addressed. (GR)

  18. Parking Structures and the Space Race.

    ERIC Educational Resources Information Center

    Milshtein, Amy

    2000-01-01

    Presents some solutions to overcrowded parking on college campuses. Tips on selecting sites for parking garages, making parking decks blend with adjacent communities, and turning parking garages into multi use facilities are addressed. (GR)

  19. Exploring Jurassic Park.

    ERIC Educational Resources Information Center

    Simmons, Patricia E.; Wiley, Clyde

    1993-01-01

    Describes several student-tested activities built around "Jurassic Park." The activities feature students engaged in role-playing scenarios, investigative research projects, journal writing and communications skills activities, cooperative learning groups, and learning experiences that make use of reading skills and mathematical knowledge. (PR)

  20. Pinnacles National Park Act

    THOMAS, 112th Congress

    Sen. Boxer, Barbara [D-CA

    2011-01-25

    05/11/2011 Committee on Energy and Natural Resources Subcommittee on National Parks. Hearings held. With printed Hearing: S.Hrg. 112-124. (All Actions) Notes: For further action, see H.R.3641, which became Public Law 112-245 on 1/10/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  1. The Clover Park Story

    ERIC Educational Resources Information Center

    Norris, Don

    1974-01-01

    Describes an aviation trades training program offered by the Clover Park schools in Washington which exposes students to all facets of the aviation industry from record keeping to air traffic control in addition to the specific skill of piloting the aircraft. (BR)

  2. Park a La Cart.

    ERIC Educational Resources Information Center

    Edwards, Susie; Roell, Amy

    1998-01-01

    Using discovery stations offers solutions for increasing attendance at park interpretive programs. Compact, portable stations can be used in playgrounds, special events, trailheads, picnic areas, campgrounds, nursing homes, and scouts and day camps. Describes a case in which stations were used 85 times and reached 4,927 visitors between July 1996…

  3. Parks or Prisons?

    ERIC Educational Resources Information Center

    Thomson, Gareth

    1998-01-01

    Presents a simulation activity in which students assume the role of grizzly bears in Banff National Park. Concepts such as species diversity, fitness, natural selection, habitat loss, extinction, and population dynamics are discussed. Children learn how human activities can affect the bear's reproductive success. Lists materials, instructional…

  4. Parks or Prisons?

    ERIC Educational Resources Information Center

    Thomson, Gareth

    1998-01-01

    Presents a simulation activity in which students assume the role of grizzly bears in Banff National Park. Concepts such as species diversity, fitness, natural selection, habitat loss, extinction, and population dynamics are discussed. Children learn how human activities can affect the bear's reproductive success. Lists materials, instructional…

  5. Pinnacles National Park Act

    THOMAS, 112th Congress

    Sen. Boxer, Barbara [D-CA

    2011-01-25

    05/11/2011 Committee on Energy and Natural Resources Subcommittee on National Parks. Hearings held. With printed Hearing: S.Hrg. 112-124. (All Actions) Notes: For further action, see H.R.3641, which became Public Law 112-245 on 1/10/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  6. Analytical and clinical performance characteristics of the Abbott RealTime MTB RIF/INH Resistance, an assay for the detection of rifampicin and isoniazid resistant Mycobacterium tuberculosis in pulmonary specimens.

    PubMed

    Kostera, Joshua; Leckie, Gregor; Tang, Ning; Lampinen, John; Szostak, Magdalena; Abravaya, Klara; Wang, Hong

    2016-12-01

    Clinical management of drug-resistant tuberculosis patients continues to present significant challenges to global health. To tackle these challenges, the Abbott RealTime MTB RIF/INH Resistance assay was developed to accelerate the diagnosis of rifampicin and/or isoniazid resistant tuberculosis to within a day. This article summarizes the performance of the Abbott RealTime MTB RIF/INH Resistance assay; including reliability, analytical sensitivity, and clinical sensitivity/specificity as compared to Cepheid GeneXpert MTB/RIF version 1.0 and Hain MTBDRplus version 2.0. The limit of detection (LOD) of the Abbott RealTime MTB RIF/INH Resistance assay was determined to be 32 colony forming units/milliliter (cfu/mL) using the Mycobacterium tuberculosis (MTB) strain H37Rv cell line. For rifampicin resistance detection, the Abbott RealTime MTB RIF/INH Resistance assay demonstrated statistically equivalent clinical sensitivity and specificity as compared to Cepheid GeneXpert MTB/RIF. For isoniazid resistance detection, the assay demonstrated statistically equivalent clinical sensitivity and specificity as compared to Hain MTBDRplus. The performance data presented herein demonstrate that the Abbott RealTime MTB RIF/INH Resistance assay is a sensitive, robust, and reliable test for realtime simultaneous detection of first line anti-tuberculosis antibiotics rifampicin and isoniazid in patient specimens.

  7. Astronomy in the National Parks

    NASA Astrophysics Data System (ADS)

    Nordgren, Tyler E.

    2009-01-01

    American national parks are fertile grounds for astronomy and planetary science outreach. They are some of the last remaining dark-sky sites the typical visitor (both U.S. and international) can still experience easily. An internal National Park Service (NPS) study shows a dark starry sky is an integral part of what visitors consider their park experience. As a result, the NPS Night Sky Team (a coordinated group of park rangers and astronomers) is measuring and monitoring the sky brightness over the parks in an attempt to promote within the park service protection of the night sky as a natural resource. A number of parks (e.g. Grand Canyon National Park) are currently expanding their night sky related visitor programs in order to take advantage of this resource and visitor interest. The national parks and their visitors are therefore an ideal audience fully "primed” to learn about aspects of astronomy or planetary science that can be, in any way, associated with the night sky. As one of the astronomers on the NPS Night Sky Team, I have been working with park service personnel on ways to target park visitors for astronomical outreach. The purpose of this outreach is twofold: 1) Strengthen popular investment in preserving dark skies, 2) Strengthen popular investment in current astronomical research. A number of avenues already being used to introduce astronomy outreach into the parks (beyond the simple "star party") will be presented.

  8. IL-1 beta induces dendritic cells to produce IL-12.

    PubMed

    Wesa, A K; Galy, A

    2001-08-01

    The cytokine IL-12, a product of dendritic cells (DC), plays a major role in cellular immunity, notably by inducing lymphocytes to produce IFN-gamma. Microbial products, T cell signals and cytokines induce the production of IL-12. Here, IL-1 beta is identified as a new IL-12-inducing agent, acting conjointly with CD40 ligand (CD40L) on human monocyte-derived DC in vitro. The effects of IL-1 beta were dose dependent, specifically blocked by neutralizing antibodies, and were observed both in immature and mature DC. Immature DC secreted more IL-12 than mature DC, but the effects of IL-1 beta were not due to a block of DC maturation as determined by analysis of DC surface markers. The mechanisms of action of IL-1 beta could be contrasted to that of other inducers of IL-12 such as IFN-gamma and lipopolysaccharide (LPS). Either IL-1 beta or IFN-gamma co-induced IL-12 with CD40L but conjointly, IL-1 beta, CD40L and IFN-gamma synergized, inducing very high levels of IL-12. The effects of IL-1 beta differed from those of LPS in that IL-1 beta, unlike LPS, could not induce IL-12 solely after IFN-gamma priming; and when combined with CD40L, IL-1 beta, unlike LPS, induced little IL-10. The mechanism of action of IL-1 beta involves IL-12 alpha mRNA up-regulation, and we show that the combination of CD40L and IL-1 beta induces high levels of IL-12 alpha and IL-12 beta mRNA in DC. Altogether, these results delineate a new mechanism linking adaptive and innate immune responses for the regulation of IL-12 production in DC and for the role of IL-1 beta in the development of cellular immunity.

  9. mTOR mediates IL-23 induction of neutrophil IL-17 and IL-22 production

    PubMed Central

    Chen, Feidi; Cao, Anthony; Yao, Suxia; Evans-Marin, Heather L; Liu, Han; Wu, Wei; Carlsen, Eric D.; Dann, Sara M; Soong, Lynn; Sun, Jiaren; Zhao, Qihong; Cong, Yingzi

    2016-01-01

    It has been shown recently that neutrophils are able to produce IL-22 and IL-17, which differentially regulate the pathogenesis of inflammatory bowel disease (IBD). However, it is still largely unknown how the neutrophil production of IL-22 and IL-17 is regulated, and their role in the pathogenesis of IBD. In this study, we found that IL-23 promoted neutrophil production of IL-17 and IL-22. IL-23 stimulated the neutrophil expression of IL-23 receptor as well as rorc and ahr. RORγt and AhR differentially regulated IL-23 induction of neutrophil IL-17 and IL-22. Additionally, IL-23 induced the activation of mTOR in neutrophils. Blockade of mTOR pathway inhibited IL-23-induced expression of rorc and ahr as well as IL-17 and IL-22 production. By utilizing a microbiota antigen specific T-cell mediated colitis model, we demonstrated that depletion of neutrophils, as well as blockade of IL-22, resulted in a significant increase in the severity of colitis, thereby indicating a protective role of neutrophils and IL-22 in chronic colitis. Collectively, our data revealed that neutrophils negatively regulate microbiota antigen specific T cell induction of colitis, and IL-23 induces neutrophil production of IL-22 and IL-17 through induction of rorc and ahr, which is mediated by mTOR pathway. PMID:27067005

  10. Parking: an effective strategy described.

    PubMed

    Herring, Philip

    2013-11-01

    A hospital car park needs to balance the demands of patients, visitors, and staff, without, for example, compromising emergency vehicles' access to the Accident & Emergency Department. However, with car ownership on the rise, the half a million car parking spaces across all Trust sites in England may not be enough to meet future demand. Philip Herring, managing director of VINCI Park UK, which designs, finances, builds, and operates, car parks for a variety of sectors, argues that having in place an effective strategy for future parking is vital to meet the growing needs of patients, visitors, and staff, as well as budgetary and environmental commitments.

  11. Interleukins (ILs), a fascinating family of cytokines. Part II: ILs from IL-20 to IL-38.

    PubMed

    Fietta, Pieranna; Costa, Elvira; Delsante, Giovanni

    2015-01-01

    Every nucleated cell can produce and respond to cytokines, extracellular proteic/glycoproteic mediators that constitute a complex, interconnected, and flexible signaling network, addressed to modulate cell behavior and homeostasis through the interaction with high-affinity surface receptors. These messenger molecules, whose main characteristics are potency, pleiotropism, and redundancy, primarily act in autocrine, paracrine, and juxtacrine way, but can also display systemic activity in endocrine-like modality. They are generally classified according to their cellular sources, three-dimensional structure, or biological functions. Among cytokines, interleukins (ILs) represent a fascinating and multifunctional group of immunomodulators that primarily mediate the leukocyte cross-talk (hence the name), and mainly regulate the immune cell proliferation, differentiation, growth, survival, activation, and functions. Up to 38 ILs have been so far identified, numbered according to the order of discovery, and grouped in different subsets, based on distinguishing structural/functional features. Due to their crucial role in regulating inflammation and immune response, ILs are known to be involved in the pathogenesis of human inflammatory/autoimmune diseases. Therefore, they have increasingly attracted great interest as effective or promising therapeutic targets. The biology and functions of the hitherto identified human ILs are reviewed and discussed: herein, ILs from IL-20 to IL-38 are presented.

  12. Interleukins (ILs), a fascinating family of cytokines. Part I: ILs from IL-1 to IL-19.

    PubMed

    Fietta, Pieranna; Costa, Elvira; Delsante, Giovanni

    2014-01-01

    Every nucleated cell can produce and respond to cytokines, extracellular proteic/glycoproteic mediators that constitute a complex, interconnected, and flexible signaling network, addressed to modulate cell behavior and homeostasis through the interaction with high-affinity surface receptors. These messenger molecules, whose main characteristics are potency, pleiotropism, and redundancy, primarily act in autocrine, paracrine, and juxtacrine way, but can also display systemic activity in endocrine-like modality. They are generally classified according to their cellular sources, three-dimensional structure, or biological functions. Among cytokines, interleukins (ILs) represent a fascinating and multifunctional group of immunomodulators that primarily mediate the leukocyte cross-talk (hence the name), and mainly regulate the immune cell proliferation, differentiation, growth, survival, activation, and functions. Up to 38 ILs have been so far identified, numbered according to the order of discovery, and grouped in different subsets, based on distinguishing structural/functional features. Due to their crucial role in regulating inflammation and immune response, ILs are known to be involved in the pathogenesis of human inflammatory/autoimmune diseases. Therefore, they have increasingly attracted great interest as effective or promising therapeutic targets. The biology and functions of the hitherto identified human ILs are reviewed and discussed: in this first section of the article, ILs from IL-1 to IL-19 are presented.

  13. 41 CFR 102-74.270 - Are vehicles required to display parking permits in parking facilities?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... display parking permits in parking facilities? 102-74.270 Section 102-74.270 Public Contracts and Property... to display parking permits in parking facilities? When the use of parking space is controlled as in... service areas must display a parking permit. This requirement may be waived in parking facilities...

  14. 41 CFR 102-74.270 - Are vehicles required to display parking permits in parking facilities?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... display parking permits in parking facilities? 102-74.270 Section 102-74.270 Public Contracts and Property... to display parking permits in parking facilities? When the use of parking space is controlled as in... service areas must display a parking permit. This requirement may be waived in parking facilities...

  15. 41 CFR 102-74.270 - Are vehicles required to display parking permits in parking facilities?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... display parking permits in parking facilities? 102-74.270 Section 102-74.270 Public Contracts and Property... to display parking permits in parking facilities? When the use of parking space is controlled as in... service areas must display a parking permit. This requirement may be waived in parking facilities...

  16. 41 CFR 102-74.270 - Are vehicles required to display parking permits in parking facilities?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... display parking permits in parking facilities? 102-74.270 Section 102-74.270 Public Contracts and Property... to display parking permits in parking facilities? When the use of parking space is controlled as in... service areas must display a parking permit. This requirement may be waived in parking facilities...

  17. 41 CFR 102-74.270 - Are vehicles required to display parking permits in parking facilities?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... display parking permits in parking facilities? 102-74.270 Section 102-74.270 Public Contracts and Property... to display parking permits in parking facilities? When the use of parking space is controlled as in... service areas must display a parking permit. This requirement may be waived in parking facilities...

  18. Comparison of the Cepheid GeneXpert and Abbott M2000 HIV-1 real time molecular assays for monitoring HIV-1 viral load and detecting HIV-1 infection.

    PubMed

    Ceffa, Susanna; Luhanga, Richard; Andreotti, Mauro; Brambilla, Davide; Erba, Fulvio; Jere, Haswel; Mancinelli, Sandro; Giuliano, Marina; Palombi, Leonardo; Marazzi, Maria Cristina

    2016-03-01

    Assessing treatment efficacy and early infant diagnosis (EID) are critical issues in HIV disease management. Point-of-care assays may greatly increase the possibility to access laboratory monitoring also in rural areas. Recently two new laboratory tests have been developed by Cepheid (Sunnyvale, California) the Xpert HIV-1 Viral Load for viral load determination and the Xpert HIV-1 Qualitative for early infant diagnosis. We conducted a study in Blantyre, Malawi, comparing the 2 methods versus the Abbott real time quantitative and qualitative assays, for viral load and EID respectively. We tested 300 plasma samples for viral load determination and 200 samples for infant diagnosis. HIV-1 RNA values of the 274 samples quantified by both assays were highly correlated (Pearson r=0.95, R(2)=0.90). In 90.9% of the cases the two methods were concordant in defining the HIV-1 RNA levels as detectable or undetectable. For EID, the Xpert HIV-1 Qualitative assay yielded the same identical results as the Abbott assay. Both the quantitative and the qualitative Xpert assays are promising tools to monitor treatment efficacy in HIV patients receiving treatment and for early diagnosis in HIV-exposed infants.

  19. Mount Rainier National Park

    USGS Publications Warehouse

    Hoffman, Robert; Woodward, Andrea; Haggerty, Patricia K.; Jenkins, Kurt J.; Griffin, Paul C.; Adams, Michael J.; Hagar, Joan; Cummings, Tonnie; Duriscoe, Dan; Kopper, Karen; Riedel, Jon; Samora, Barbara; Marin, Lelaina; Mauger, Guillaume S.; Bumbaco, Karen; Littell, Jeremy S.

    2014-01-01

    Natural Resource Condition Assessments (NRCAs) evaluate current conditions for a subset of natural resources and resource indicators in national parks. NRCAs also report on trends in resource condition (when possible), identify critical data gaps, and characterize a general level of confidence for study findings. The resources and indicators emphasized in a given project depend on the park’s resource setting, status of resource stewardship planning and science in identifying high-priority indicators, and availability of data and expertise to assess current conditions for a variety of potential study resources and indicators. Although the primary objective of NRCAs is to report on current conditions relative to logical forms of reference conditions and values, NRCAs also report on trends, when appropriate (i.e., when the underlying data and methods support such reporting), as well as influences on resource conditions. These influences may include past activities or conditions that provide a helpful context for understanding current conditions and present-day threats and stressors that are best interpreted at park, watershed, or landscape scales (though NRCAs do not report on condition status for land areas and natural resources beyond park boundaries). Intensive cause-andeffect analyses of threats and stressors, and development of detailed treatment options, are outside the scope of NRCAs. It is also important to note that NRCAs do not address resources that lack sufficient data for assessment. For Mount Rainier National Park, this includes most invertebrate species and many other animal species that are subject to significant stressors from climate change and other anthropogenic sources such as air pollutants and recreational use. In addition, we did not include an analysis of the physical hydrology associated with streams (such as riverine landforms, erosion and aggradation which is significant in MORA streams), due to a loss of staff expertise from the USGS

  20. Pinnacles National Park Act

    THOMAS, 112th Congress

    Sen. Boxer, Barbara [D-CA

    2011-01-25

    Senate - 05/11/2011 Committee on Energy and Natural Resources Subcommittee on National Parks. Hearings held. With printed Hearing: S.Hrg. 112-124. (All Actions) Notes: For further action, see H.R.3641, which became Public Law 112-245 on 1/10/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  1. The energy Park

    NASA Astrophysics Data System (ADS)

    Manheimer, Wallace

    2005-10-01

    If world development is to continue, per capita energy use in the developing world must increase to levels in the developed world. Restrictions on how much CO2 mankind can responsibly put into the atmosphere complicate the task further. Studies show that by 2050 the world will require an additional 10-30 terawatts (TW) of carbon free power, at least as much additional, as the 10 TW generated today with fossil fuel. Neither mined uranium nor renewable energy is capable of sustained power production at this level. This paper proposes, an "energy park", a self contained unit a square mile or two in area which supplies about 7 GW of electrical power or hydrogen, emits no CO2, has little or no proliferation problem, and cleans up its own waste. Most of the energy is supplied by conventional nuclear power plants. However the nuclear fuel is bred by a fusion reactor, which is the key to the energy park. The waste cleanup is done by a combination of fission, fusion, and patience. There is neither long time storage nor long distance travel for materials with proliferation risk or long lived radio nuclides. Thus only thorium comes into the park, and only electricity and hydrogen go out.

  2. Mountain bikes and metropolitan park districts: issues and trends identified by state parks and state park districts in Ohio

    Treesearch

    Eric L. Longsdorf; Ruthie Kucharewski

    2007-01-01

    This study explored selected issues and trends related to mountain biking within Ohio State Parks and Park Districts. A convenience sample of 21 State Parks and 26 Park Districts completed a 24-item survey assessing mountain bike: (a) access, (b) activity levels, (c) planning, and (d) management. Results indicated that 86 percent of State Parks participating in the...

  3. Canyonlands National Park, UT, USA

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Desert and mountain scenery along the Utah/Colorado border are displayed in this scene of the Canyonlands National Park, UT (39.0N, 110.0W). The park occupies the near center of the image, displaying spectacular incised meanders and the bulls-eye structure of Upheaval Dome (a salt dome). The Green River and the Colorado River flow southward to join (off scene) before flowing through the Grand Canyon National Park.

  4. Canyonlands National Park, UT, USA

    NASA Technical Reports Server (NTRS)

    1992-01-01

    Desert and mountain scenery along the Utah/Colorado border are displayed in this scene of the Canyonlands National Park, UT (39.0N, 110.0W). The Park occuppies the near center of the image, displaying spectacular incised meanders and the bulls-eye structure of Upheaval Dome (a salt dome). The Green River and the Colorado River flow southward to join off scene before flowing through the Grand Canyon National Park.

  5. Canyonlands National Park, UT, USA

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Desert and mountain scenery along the Utah/Colorado border are displayed in this scene of the Canyonlands National Park, UT (39.0N, 110.0W). The park occupies the near center of the image, displaying spectacular incised meanders and the bulls-eye structure of Upheaval Dome (a salt dome). The Green River and the Colorado River flow southward to join (off scene) before flowing through the Grand Canyon National Park.

  6. Automated Car Park Management System

    NASA Astrophysics Data System (ADS)

    Fabros, J. P.; Tabañag, D.; Espra, A.; Gerasta, O. J.

    2015-06-01

    This study aims to develop a prototype for an Automated Car Park Management System that will increase the quality of service of parking lots through the integration of a smart system that assists motorist in finding vacant parking lot. The research was based on implementing an operating system and a monitoring system for parking system without the use of manpower. This will include Parking Guidance and Information System concept which will efficiently assist motorists and ensures the safety of the vehicles and the valuables inside the vehicle. For monitoring, Optical Character Recognition was employed to monitor and put into list all the cars entering the parking area. All parking events in this system are visible via MATLAB GUI which contain time-in, time-out, time consumed information and also the lot number where the car parks. To put into reality, this system has a payment method, and it comes via a coin slot operation to control the exit gate. The Automated Car Park Management System was successfully built by utilizing microcontrollers specifically one PIC18f4550 and two PIC16F84s and one PIC16F628A.

  7. 76 FR 22001 - National Park Week, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-20

    ... Documents#0;#0; ] Proclamation 8656 of April 15, 2011 National Park Week, 2011 By the President of the.... ``Healthy Parks, Healthy People,'' the focus for this year's National Park Week, highlights the role of... waived during National Park Week. All Americans can visit www.NPS.gov to find nearby parks where history...

  8. 32 CFR 636.14 - Parking.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... parking in handicapped and Commanding General reserved parking spaces at Fort Stewart/Hunter Army Airfield soldier service facilities and assess points in accordance with Table 634.46 in § 634.46 of this... parking spaces and parking on a yellow curb among others. (b) Reserved parking spaces in areas under the...

  9. 32 CFR 636.14 - Parking.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... parking in handicapped and Commanding General reserved parking spaces at Fort Stewart/Hunter Army Airfield soldier service facilities and assess points in accordance with Table 634.46 in § 634.46 of this... parking spaces and parking on a yellow curb among others. (b) Reserved parking spaces in areas under the...

  10. 32 CFR 636.14 - Parking.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... parking in handicapped and Commanding General reserved parking spaces at Fort Stewart/Hunter Army Airfield soldier service facilities and assess points in accordance with Table 634.46 in § 634.46 of this... parking spaces and parking on a yellow curb among others. (b) Reserved parking spaces in areas under the...

  11. 32 CFR 636.14 - Parking.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... parking in handicapped and Commanding General reserved parking spaces at Fort Stewart/Hunter Army Airfield soldier service facilities and assess points in accordance with Table 634.46 in § 634.46 of this... parking spaces and parking on a yellow curb among others. (b) Reserved parking spaces in areas under the...

  12. The IL-23/IL-22/IL-18 axis in murine Campylobacter jejuni infection.

    PubMed

    Heimesaat, Markus M; Grundmann, Ursula; Alutis, Marie E; Fischer, André; Göbel, Ulf B; Bereswill, Stefan

    2016-01-01

    Human Campylobacter jejuni infections are worldwide on the rise. Information about the distinct molecular mechanisms underlying campylobacteriosis, however, are scarce. In the present study we investigated whether cytokines including IL-23, IL-22 and IL-18 sharing pivotal functions in host immunity were involved in mediating immunopathological responses upon C. jejuni infection. To address this, conventionally colonized IL-23p19(-/-), IL-22(-/-) and IL-18(-/-) mice were perorally infected with C. jejuni strain ATCC 43431. Respective gene-deficient, but not wildtype mice were susceptible to C. jejuni infection and could be readily colonized with highest pathogenic loads in the terminal ileum and colon at day 14 postinfection (p.i.). In IL-23p19(-/-), IL-22(-/-) and IL-18(-/-) mice viable C. jejuni were detected in MLNs, but did not translocate to spleen, liver, kidney and blood in the majority of cases. Susceptible IL-22(-/-), but neither IL-23p19(-/-), nor IL-18(-/-) mice harbored higher intestinal commensal E. coli loads when compared to resistant wildtype mice. Alike C. jejuni, commensal E. coli did not translocate from the intestinal to extra-intestinal tissue sites. Despite C. jejuni infection, mice lacking IL-23p19, IL-22 or IL-18 exhibited less apoptotic cells, but higher numbers of proliferating cells in their colonic epithelium as compared to wildtype mice at day 14 p.i. Less pronounced apoptosis was parallelled by lower abundance of neutrophils within the colonic mucosa and lamina propria of infected IL-23p19(-/-) and IL-22(-/-) as compared to wildtype control mice, whereas less distinct colonic TNF secretion could be measured in IL-22(-/-) and IL-18(-/-) than in wildtype mice at day 14 p.i. Notably, in infected IL-22(-/-) mice, colonic IL-23p19 mRNA levels were lower, whereas the other way round, colonic IL-22 expression rates were lower in IL-23p19(-/-) mice as compared to wildtype controls. Moreover, IL-18 mRNA was less distinctly expressed in large

  13. Comparative evaluation of the Abbott HIV-1 RealTime™ assay with the Standard Roche COBAS® Amplicor™ HIV-1 Monitor® Test, v1.5 for determining HIV-1 RNA levels in plasma specimens from Pune, India.

    PubMed

    Khopkar, Priyanka; Mallav, Vikas; Chidrawar, Shweta; Kulkarni, Smita

    2013-07-01

    The implementation of cost effective HIV-1 viral load assays in resource-limited settings have been an impediment for monitoring HIV-1 therapy. A study involving the comparative analytical performance of two HIV-1 viral load assays - Standard Roche COBAS(®) Amplicor™ HIV-1 Monitor(®) Test, version 1.5 (Roche Diagnostics, Basel, Switzerland) and Abbott HIV-1 RealTime™ assay (Abbott Molecular, Wiesbaden, Germany) was performed using 125 specimens in Pune, India. A strong correlation was observed between the manual endpoint reverse transcriptase polymerase chain reaction assay and the recent real time polymerase chain reaction assay (r=0.989, p value<0.0001) and agreement was 94.4%. Results of the study indicate a higher sensitivity of the Abbott HIV-1 RealTime™ assay for HIV-1 Virology Quality Assurance copy controls as compared to the Standard Roche COBAS(®) Amplicor™ HIV-1 Monitor(®) Test, version 1.5. Furthermore, features of the Abbott m2000rt RealTime™ PCR assay platform such as higher analytical sensitivity, automated/manual extraction platforms for high/low sample throughputs and ability to quantify a variety of infectious agents (Hepatitis B virus, Hepatitis C virus, Human Papillomavirus and Neisseria gonorrhoeae/Chlamydia trachomatis) justify its suitability in resource-limited Indian settings. Besides, the study also highlights utility of the precise Virology Quality Assurance validation template in performance evaluation of various quantitative viral load assays.

  14. Comparison of the artus Epstein-Barr virus (EBV) PCR kit and the Abbott RealTime EBV assay for measuring plasma EBV DNA loads in allogeneic stem cell transplant recipients.

    PubMed

    Vinuesa, Víctor; Solano, Carlos; Giménez, Estela; Navarro, David

    2017-02-24

    The ability of the artus Epstein-Barr virus (EBV) PCR kit and the Abbott RealTime EBV PCR assay to detect and quantify plasma EBV DNAemia was compared. The agreement between these assays was 95.8%. The EBV DNA loads measured by the two assays significantly correlated (P=< 0.0001).

  15. Assessment of hydrologic and water quality data collected in Abbotts Lagoon watershed, Point Reyes National Seashore, California, during water years 1999 and 2000

    USGS Publications Warehouse

    Kratzer, Charles R.; Saleh, Dina K.; Zamora, Celia

    2006-01-01

    Abbotts Lagoon is part of Point Reyes National Seashore, located about 40 miles northwest of San Francisco and about 20 miles south of Bodega Bay. Water-quality samples were collected quarterly during water year 1999 at a site in each of three connected lagoons that make up Abbotts Lagoon and at a site in its most significant tributary. The quarterly samples were analyzed for major ions, nutrients, and chlorophyll-a. A bed-sediment sample was collected in each lagoon during August 1999 and was analyzed for organic carbon, iron, and total phosphorus. Seven tributaries were sampled during a February 1999 storm and four during an April 1999 storm. These samples were analyzed only for nutrients. One storm sample collected in April 1999 from a tributary downstream of the I Ranch dairy was analyzed for a suite of 47 compounds indicative of wastewater. Continuous water-level recorders were installed in the most significant tributary and the two largest lagoons for portions of the study. A water budget analysis for an April 2000 storm indicated that the main tributary accounted for 85 percent of surface inflows to Abbotts Lagoon. The portion of the surface inflow from the main tributary was lower in the February 1999 storms and is a function of upstream storage and vegetative growth in the tributary basins. Another water budget analysis for a period of no surface inflow (June and July 2000) indicated that the net ground-water contribution was an outflow (seepage) from Abbotts Lagoon of about 0.3 ft3/s. Salinity increased and nutrient concentrations decreased from upstream to downstream in the chain of lagoons. The lower lagoon, nearest the ocean, had less organic carbon and total phosphorus in the bed sediment than the upper lagoons. The two tributaries originating in the I Ranch dairy had the highest concentrations of nutrients in storm runoff, and the highest loading rates and yields of ammonia and phosphorus. These tributaries account for only 10.3 percent of the area

  16. The need for a sequencing-based assay to supplement the Abbott m2000 RealTime HCV Genotype II assay: a 1 year analysis.

    PubMed

    Benedet, Marlin; Adachi, Dena; Wong, Anita; Wong, Sallene; Pabbaraju, Kanti; Tellier, Raymond; Tang, Julian W

    2014-07-01

    Hepatitis C (HCV) genotyping is important for treatment planning. The Abbott m2000 RealTime HCV Genotype II assay is a PCR-based assay targeting specific regions of the 5'NCR gene for genotypes 1-6, and the NS5b gene for subgenotypes 1a/1b. However, not all genotypes can be resolved, with results being reported as: 'indeterminate', 'mixed', 'genotype X reactivity with Y', or just the major genotype 1 alone. To assess the supplementary testing required for these unresolved HCV genotypes, these samples were tested further using an in-house core/E1 sequencing assay. The resulting genotypes/subgenotypes were assigned using phylogenetic analysis with reference HCV genotype sequences. Additional testing was conducted using the INNO-LiPA HCV II assay for truly mixed genotypes. Out of 1052 samples tested, 89 (8.5%) underwent further sequencing to determine the HCV genotype: 16 that were 'indeterminate' on the m2000, were mostly genotype 2s and 3s by sequencing; 12 that were 'mixed', were mostly one of the genotypes reported in the mixture; 7 that were 'X reactivity with Y', were usually genotype X; 54 that gave just a major genotype 1 result were mostly 1a, with some 6 and 1b, and a few 1c. For three truly mixed genotypes, additional testing using the VERSANT(®) HCV Genotype Assay (LiPA) 2.0, showed two mixed 1 and 3, and one indistinguishable 6c-6l genotypes. The Abbott m2000 RealTime HCV Genotype II assay can resolve most (∼90%) HCV genotypes. However in 9-10% of cases, to fully resolve the genotype, additional testing is required. Copyright © 2014 Elsevier B.V. All rights reserved.

  17. 32 CFR 636.14 - Parking.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... INVESTIGATIONS MOTOR VEHICLE TRAFFIC SUPERVISION (SPECIFIC INSTALLATIONS) Fort Stewart, Georgia § 636.14 Parking... parking in handicapped and Commanding General reserved parking spaces at Fort Stewart/Hunter Army...

  18. New Challenges in Campus Parking Management.

    ERIC Educational Resources Information Center

    Mah, Allan

    2000-01-01

    Examines the challenges campus parking professionals face from the increased demands of organizations to improve parking service levels with diminishing resources. Campus parking operations are explored with an awareness of the needs, attitudes, and demands of customers in mind. (GR)

  19. New Challenges in Campus Parking Management.

    ERIC Educational Resources Information Center

    Mah, Allan

    2000-01-01

    Examines the challenges campus parking professionals face from the increased demands of organizations to improve parking service levels with diminishing resources. Campus parking operations are explored with an awareness of the needs, attitudes, and demands of customers in mind. (GR)

  20. Ecology of an urban park

    Treesearch

    Derek J. Coleman

    1977-01-01

    A controversial issue in the city of Kitchener, Ontario, involves the proposed extension of a boulevard through Lakeside Park. A study of this proposal revealed several facets of human interrelations with an urban park. Most important, there was a large gap between the perception and the reality of environmental quality. This has several practical implications in...

  1. An Amusement Park Physics Competition

    ERIC Educational Resources Information Center

    Moll, Rachel F.

    2010-01-01

    Amusement park physics is a popular way to reinforce physics concepts and to motivate physics learners. This article describes a novel physics competition where students use simple tools to take amusement park ride measurements and use the data to answer challenging exam questions. Research into the impact of participating in the competition…

  2. What's happening in our parks?

    Treesearch

    G. Scott Place

    2001-01-01

    Facilities allow children and adults to adapt, improvise, create, and contribute significantly to the mental and physical well-being of the park users. Parks across the continent contain facilities designed for the enjoyment of the consumer. However, are facilities really used as designed and used to the intended level making them worth the cost of development? An...

  3. California Community Colleges Parking Survey.

    ERIC Educational Resources Information Center

    McIntyre, Chuck

    In 1990, a representative sample of 25 California community colleges was contacted by telephone to determine their parking policies and practices. The colleges were sampled on the basis of location and size. Study findings included the following: (1) 17 of the colleges reported that they had insufficient numbers of on-campus parking spaces; (2)…

  4. Redefining Public Parks and Recreation.

    ERIC Educational Resources Information Center

    Godbey, Geoffrey

    1991-01-01

    For public recreation, park, and leisure services to prosper in the financially troubled 1990s, they will have to be recognized as a primary health provider. By today's standards, health, recreation, and leisure are practically synonymous. The article rethinks the concepts of health, illness, parks, and recreation. (SM)

  5. An Amusement Park Physics Competition

    ERIC Educational Resources Information Center

    Moll, Rachel F.

    2010-01-01

    Amusement park physics is a popular way to reinforce physics concepts and to motivate physics learners. This article describes a novel physics competition where students use simple tools to take amusement park ride measurements and use the data to answer challenging exam questions. Research into the impact of participating in the competition…

  6. Recall of LCx Neisseria gonorrhoeae assay and implications for laboratory testing for N. gonorrhoeae and Chlamydia trachomatis.

    PubMed

    2002-08-16

    On July 18, 2002, Abbott Laboratories (Abbott Park, IL) initiated a voluntary recall of its LCx Neisseria gonorrhoeae Assay (List Numbers 8A48-81 and 8A48-82) because, during routine quality assurance testing, several reagent lots failed to meet the analytical sensitivity described in the product insert. The cause of the failure is under investigation by the company. Abbott Laboratories has sent a letter to its customers informing them of this recall and the specific reagent lot numbers not meeting the analytical sensitivity.

  7. Helping You Buy ILS

    ERIC Educational Resources Information Center

    Cibbarelli, Pamela R.

    2010-01-01

    This article is the fourth in a series of articles published annually by "Computers in Libraries" surveying integrated library systems and services (ILSs). The purpose of the annual survey is to enable comparison of the ILSs that are available. ILS vendors are in constant pursuit of an ever-changing, consistently vague definition of what the…

  8. IL-10 regulates murine lupus.

    PubMed

    Yin, Zhinan; Bahtiyar, Gul; Zhang, Na; Liu, Lanzhen; Zhu, Ping; Robert, Marie E; McNiff, Jennifer; Madaio, Michael P; Craft, Joe

    2002-08-15

    MRL/MpJ-Tnfrsf6(lpr) (MRL/MpJ-Fas(lpr); MRL-Fas(lpr)) mice develop a spontaneous lupus syndrome closely resembling human systemic lupus erythematosus. To define the role of IL-10 in the regulation of murine lupus, IL-10 gene-deficient (IL-10(-/-)) MRL-Fas(lpr) (MRL-Fas(lpr) IL-10(-/-)) mice were generated and their disease phenotype was compared with littermates with one or two copies of an intact IL-10 locus (MRL-Fas(lpr) IL-10(+/-) and MRL-Fas(lpr) IL-10(+/+) mice, respectively). MRL-Fas(lpr) IL-10(-/-) mice developed severe lupus, with earlier appearance of skin lesions, increased lymphadenopathy, more severe glomerulonephritis, and higher mortality than their IL-10-intact littermate controls. The increased severity of lupus in MRL-Fas(lpr) IL-10(-/-) mice was closely associated with enhanced IFN-gamma production by both CD4(+) and CD8(+) cells and increased serum concentration of IgG2a anti-dsDNA autoantibodies. The protective effect of IL-10 in this lupus model was further supported by the observation that administration of rIL-10 reduced IgG2a anti-dsDNA autoantibody production in wild-type MRL-Fas(lpr) animals. In summary, our results provide evidence that IL-10 can down-modulate murine lupus through inhibition of pathogenic Th1 cytokine responses. Modulation of the level of IL-10 may be of potential therapeutic benefit for human lupus.

  9. IL-22R Ligands IL-20, IL-22, and IL-24 Promote Wound Healing in Diabetic db/db Mice

    PubMed Central

    Kolumam, Ganesh; Wu, Xiumin; Lee, Wyne P.; Hackney, Jason A.; Zavala-Solorio, Jose; Gandham, Vineela; Danilenko, Dimitry M.; Arora, Puneet; Wang, Xiaoting; Ouyang, Wenjun

    2017-01-01

    Diabetic foot ulcers (DFU) are one of the major complications in type II diabetes patients and can result in amputation and morbidity. Although multiple approaches are used clinically to help wound closure, many patients still lack adequate treatment. Here we show that IL-20 subfamily cytokines are upregulated during normal wound healing. While there is a redundant role for each individual cytokine in this subfamily in wound healing, mice deficient in IL-22R, the common receptor chain for IL-20, IL-22, and IL-24, display a significant delay in wound healing. Furthermore, IL-20, IL-22 and IL-24 are all able to promote wound healing in type II diabetic db/db mice. Mechanistically, when compared to other growth factors such as VEGF and PDGF that accelerate wound healing in this model, IL-22 uniquely induced genes involved in reepithelialization, tissue remodeling and innate host defense mechanisms from wounded skin. Interestingly, IL-22 treatment showed superior efficacy compared to PDGF or VEGF in an infectious diabetic wound model. Taken together, our data suggest that IL-20 subfamily cytokines, particularly IL-20, IL-22, and IL-24, might provide therapeutic benefit for patients with DFU. PMID:28125663

  10. Wheeling and Dealing in the National Parks

    ERIC Educational Resources Information Center

    Howe, Sydney

    1973-01-01

    Motor vehicles and commercialism have generated serious problems within the national park system. A Conservation Foundation suggests new directions in management for the National Park Service. (Editors)

  11. Yosemite National Park

    NASA Image and Video Library

    2017-09-28

    Naked summits alternate with forested lowlands in Yosemite Valley, part of California’s Yosemite National Park. During the Pleistocene Ice Age, glaciers sculpted the underlying rocks in this region, leaving behind canyons, waterfalls, rugged peaks, and granite domes. As the ice retreated, forests grew, but forests only extend as high as 2,900 meters (9,500 feet) above sea level. Above the tree line are rocky landscapes with sparse alpine vegetation. So from the sky, Yosemite Valley appears as a light-and-dark patchwork of forest, rock, and shadow. The Enhanced Thematic Mapper Plus on NASA’s Landsat 7 satellite captured this true-color image of part of Yosemite Valley on August 18, 2001. The valley runs roughly east-west, and tall granite peaks lining the valley’s southern side cast long shadows across the valley floor. On the valley’s northern side, steep slopes appear almost white. Along the valley floor, roadways form narrow, meandering lines of off-white, past parking lots, buildings, and meadows. On the north side of Yosemite Valley is El Capitan. Shooting straight up more than 915 meters (3,000 feet) above the valley floor, El Capitan is considered the largest granite monolith in the world. This granite monolith sits across the valley from Bridalveil Fall, one of the valley’s most prominent waterfalls. Read more: go.nasa.gov/2bzGo3d Credit: NASA/Landsat7 NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

  12. Renew the parks: Renewable energy in the National Park Service

    SciTech Connect

    DeNio, D.

    1997-12-31

    The National Park Service (NPS) is the steward of some of the world`s finest natural and cultural resources. When the Park Service celebrated its 75th birthday in 1991, it charted a course for how to accomplish its mission into the next century. Incorporating sustainability and sustainable design into all NPS operations and development is one means of meeting the challenges that face the National Park Service. The main components of sustainable design include energy conservation and the use of renewable energy sources, including solar, wind, geothermal, micro-hydro, biomass, and tidal. The focus of this paper is photovoltaic (PV)--the conversion of sunlight to direct current electricity.

  13. Aftermath of Griffith Park Fire

    NASA Technical Reports Server (NTRS)

    2007-01-01

    In mid-May 2007, wind-driven flames raced through Griffith Park in Los Angeles, forcing hasty evacuations and threatening numerous famous landmarks and tourist spots, such as the Los Angeles Zoo and the Hollywood Sign. Ultimately, no one was injured in the fire, which may have been started by a cigarette. About 800 acres burned in the urban park, which is itself a Hollywood landmark, having been the location for several movies, including Rebel Without A Cause. This image of the park was captured by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite on June 6, 2007, about a month after the fire. ASTER detects both visible and infrared wavelengths of light, and both kinds have been used to make this image. Vegetation appears in various shades of red, while the burned areas appear charcoal. Roads and dense urban areas appear purplish-gray or white. Water is dark blue. Large burned areas are evident in the northwest and southeast parts of the park, with scattered smaller patches along the southern margin. Some botanical gardens and parts of a bird sanctuary, as well as some park structures like restrooms, were destroyed. The park's unburned, natural vegetation appears brick red, while the irrigated golf courses adjacent to the park are bright red. NASA image created by Jesse Allen, using data provided courtesy of the NASA/GSFC/MITI/ERSDAC/JAROS, and U.S./Japan ASTER Science Team.

  14. Aftermath of Griffith Park Fire

    NASA Technical Reports Server (NTRS)

    2007-01-01

    In mid-May 2007, wind-driven flames raced through Griffith Park in Los Angeles, forcing hasty evacuations and threatening numerous famous landmarks and tourist spots, such as the Los Angeles Zoo and the Hollywood Sign. Ultimately, no one was injured in the fire, which may have been started by a cigarette. About 800 acres burned in the urban park, which is itself a Hollywood landmark, having been the location for several movies, including Rebel Without A Cause. This image of the park was captured by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite on June 6, 2007, about a month after the fire. ASTER detects both visible and infrared wavelengths of light, and both kinds have been used to make this image. Vegetation appears in various shades of red, while the burned areas appear charcoal. Roads and dense urban areas appear purplish-gray or white. Water is dark blue. Large burned areas are evident in the northwest and southeast parts of the park, with scattered smaller patches along the southern margin. Some botanical gardens and parts of a bird sanctuary, as well as some park structures like restrooms, were destroyed. The park's unburned, natural vegetation appears brick red, while the irrigated golf courses adjacent to the park are bright red. NASA image created by Jesse Allen, using data provided courtesy of the NASA/GSFC/MITI/ERSDAC/JAROS, and U.S./Japan ASTER Science Team.

  15. 76 FR 80393 - Notice of Inventory Completion: Field Museum of Natural History, Chicago, IL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-23

    ... Inventory Completion: Field Museum of Natural History, Chicago, IL AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Field Museum of Natural History has completed an inventory of human remains... History. Repatriation of the human remains and associated funerary objects to the Indian tribes...

  16. 77 FR 49349 - Safety Zone; Chicago Air and Water Show, Lake Michigan, Chicago, IL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-16

    ... CFR Part 165 RIN 1625-AA00 Safety Zone; Chicago Air and Water Show, Lake Michigan, Chicago, IL AGENCY... deviation to the Chicago Air and Water Show safety zone on Lake Michigan near Lincoln Park. This action is... during the Chicago Air and Water Show. This safety zone is necessary to protect spectators and vessels...

  17. Canyonlands National Park, UT, USA

    NASA Image and Video Library

    1973-06-22

    SL2-81-014 (22 June 1973) --- Desert and mountain scenery along the Utah/Colorado border are displayed in this scene of the Canyonlands National Park, UT (39.0N, 110.0W). The park occupies the near center of the image, displaying spectacular incised meanders and the bulls-eye structure of Upheaval Dome (a salt dome). The Green River and the Colorado River flow southward to join (off scene) before flowing through the Grand Canyon National Park. Photo credit: NASA

  18. Associations of interleukin (IL)-1β, IL-1 receptor antagonist, and IL-10 with dental caries.

    PubMed

    Cogulu, Dilsah; Onay, Huseyin; Ozdemir, Yasemin; I Aslan, Gulcin; Ozkinay, Ferda; Kutukculer, Necil; Eronat, Cemal

    2015-03-01

    Streptococcus mutans is important in dental caries. Although the role of cytokines in the pathogenesis of dental caries is not clear, components of S. mutans were found to stimulate production of pro-inflammatory cytokines. We examined the associations of interleukin (IL)-1β, IL-1 receptor antagonist (IL-1ra), and IL-10 with dental caries. Unstimulated whole saliva and blood samples were obtained from 108 children aged 6-12 years with high caries (decayed, missing, or filled teeth [dmft/DMFT] index >4, n = 37), moderate caries (dmft/DMFT = 1-4, n = 37), or caries-free (dmft/DMFT = 0, n = 34). S. mutans level was classified as low (<10(5) colony-forming units [CFU]/mL) or high (≥10(5) CFU/mL). Saliva and serum concentrations of IL-1β, IL-1ra, and IL-10 were determined by ELISA. IL-1β, IL-1ra, and IL-10 gene polymorphisms were genotyped using PCR and restriction fragment length polymorphism analysis. The chi-square, Mann-Whitney U, one-way ANOVA, posthoc, Fisher's exact, and t tests were used in statistical analysis. Dental caries was not correlated with salivary or serum concentrations of the studied cytokines. S. mutans level positively correlated with saliva IL-1β concentration and inversely correlated with saliva IL-1ra concentration. There was no correlation of IL-1β, IL-1ra, or IL-10 gene polymorphisms with dental caries. S. mutans is important in stimulating saliva IL-1β and inhibiting IL-1ra. Future studies of associations between cytokines and dental caries should investigate additional cytokines and enroll a larger number of participants.

  19. Interleukin (IL)-19, IL-20 and IL-24 are produced by and act on keratinocytes and are distinct from classical ILs.

    PubMed

    Kunz, Stefanie; Wolk, Kerstin; Witte, Ellen; Witte, Katrin; Doecke, Wolf-Dietrich; Volk, Hans-Dieter; Sterry, Wolfram; Asadullah, Khusru; Sabat, Robert

    2006-12-01

    Due to their structural similarity, interleukin (IL)-19, IL-20, IL-22, IL-24 and IL-26 were combined with IL-10 in the so-called IL-10 family. To expand the knowledge on IL-19, IL-20 and IL-24, we systematically and quantitatively analysed the expression of these mediators and their receptor chains in vitro and in vivo under various conditions and in comparison with other IL-10 family members. In vitro, IL-19, IL-20 and IL-24 were produced not only by activated immune cells, particularly monocytes, but also to a similar extent by keratinocytes. IL-1beta increased the expression of these mediators 1000-fold (IL-19) and 10-fold (IL-20 and IL-24) in keratinocytes. In vivo, these cytokines were expressed preferentially in inflamed tissues. The absence of either R1 chain for the two types of receptor complexes for these cytokines (IL-20R1/IL-20R2 and IL-22R1/IL-20R2) on immune cells implies that they cannot act on these cells. In fact, IL-19, IL-20 and IL-24 did not induce activation of signal transducer and activator of transcription (STAT) molecules in immune cells. Instead, several tissues, particularly the skin, tissues from the reproductive and respiratory systems, and various glands appeared to be the main targets of these mediators. Keratinocytes expressed both receptor complexes; however, the expression of IL-22R1 was 10 times higher than that of IL-20R1. Interferon-gamma further increased the expression of IL-22R1 and decreased that of IL-20R1, suggesting that under T1 cytokine conditions these mediators primarily affect keratinocytes via the IL-22R1/IL-20R2 complex. In summary, these data support the notion that IL-19, IL-20 and IL-24 are distinct from classical ILs and constitute a separate subfamily of mediators within the IL-10 family.

  20. 77 FR 24575 - National Park Week, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-25

    ... Documents#0;#0; #0; #0;Title 3-- #0;The President ] Proclamation 8801 of April 20, 2012 National Park Week... National Park Week, all 397 National Parks will offer free admission from April 21 through April 29, 2012... as our National Parks.'' This week, we honor the uniquely American idea behind them: that each of us...

  1. Resident perceptions of Vermont State Parks

    Treesearch

    Herbert E. Echelberger; Thomas A. More

    1992-01-01

    This report describes results of a survey to determine Vermont residents' opinions about their state park system. Over 400 responses were obtained from current park users and nearly 300 came from non-users. Results suggest that both day and overnight state park users are quite satisfied with the quality of services and facilities at the Vermont park they had most...

  2. 75 FR 12254 - National Park Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-15

    ... National Park Service AGENCY: National Park Service, U.S. Department of the Interior. ACTION: National... National Center for Preservation Technology and Training, National Park Service, will meet on Thursday and.... Cordell, Executive Director, National Center for Preservation Technology and Training, National Park...

  3. Teacher's Guide to Independence National Historical Park.

    ERIC Educational Resources Information Center

    National Park Service (Dept. of Interior), Philadelphia, PA. Independence National Historical Park.

    Independence National Historical Park, located in Philadelphia, Pennsylvania, is operated by the National Park Service. The park was authorized by an Act of Congress on June 28, 1948, and formally established on July 4, 1956. The mission of Independence National Historical Park is to preserve its stories, buildings, and artifacts as a source of…

  4. 15 CFR 265.17 - Parking permits.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Parking permits. 265.17 Section 265.17... Parking permits. No person, except visitors, shall park a motor vehicle on the site without having a valid parking permit displayed on such motor vehicle in compliance with instructions of the issuing authority...

  5. 23 CFR 1235.6 - Parking.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Parking. 1235.6 Section 1235.6 Highways NATIONAL HIGHWAY... UNIFORM SYSTEM FOR PARKING FOR PERSONS WITH DISABILITIES § 1235.6 Parking. Special license plates... Symbol of Access shall be the only recognized means of identifying vehicles permitted to utilize parking...

  6. 23 CFR 1235.6 - Parking.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 23 Highways 1 2011-04-01 2011-04-01 false Parking. 1235.6 Section 1235.6 Highways NATIONAL HIGHWAY... UNIFORM SYSTEM FOR PARKING FOR PERSONS WITH DISABILITIES § 1235.6 Parking. Special license plates... Symbol of Access shall be the only recognized means of identifying vehicles permitted to utilize parking...

  7. 15 CFR 265.17 - Parking permits.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Parking permits. 265.17 Section 265.17... Parking permits. No person, except visitors, shall park a motor vehicle on the site without having a valid parking permit displayed on such motor vehicle in compliance with instructions of the issuing authority...

  8. Jurassic Park: Adventure in Learning.

    ERIC Educational Resources Information Center

    Shams, Marcia; Boteler, Trina

    1993-01-01

    Describes using the movie "Jurassic Park" as a foundation for a middle school interdisciplinary unit involving science, math, language arts, history, and geography. Suggested books and activities are presented. (PR)

  9. STS-130 Nationals Park Visit

    NASA Image and Video Library

    2010-04-20

    NASA STS-130 Pilot Terry Virts, right, is interviewed by Mid-Atlantic Sports Network (MASN) reporter Debbie Taylor at Nationals Park Tuesday, April 20, 2010, in Washington. Photo Credit: (NASA/Carla Cioffi)

  10. Jurassic Park: Adventure in Learning.

    ERIC Educational Resources Information Center

    Shams, Marcia; Boteler, Trina

    1993-01-01

    Describes using the movie "Jurassic Park" as a foundation for a middle school interdisciplinary unit involving science, math, language arts, history, and geography. Suggested books and activities are presented. (PR)

  11. Multinational underground nuclear parks

    SciTech Connect

    Myers, C.W.; Giraud, K.M.

    2013-07-01

    Newcomer countries expected to develop new nuclear power programs by 2030 are being encouraged by the International Atomic Energy Agency to explore the use of shared facilities for spent fuel storage and geologic disposal. Multinational underground nuclear parks (M-UNPs) are an option for sharing such facilities. Newcomer countries with suitable bedrock conditions could volunteer to host M-UNPs. M-UNPs would include back-end fuel cycle facilities, in open or closed fuel cycle configurations, with sufficient capacity to enable M-UNP host countries to provide for-fee waste management services to partner countries, and to manage waste from the M-UNP power reactors. M-UNP potential advantages include: the option for decades of spent fuel storage; fuel-cycle policy flexibility; increased proliferation resistance; high margin of physical security against attack; and high margin of containment capability in the event of beyond-design-basis accidents, thereby reducing the risk of Fukushima-like radiological contamination of surface lands. A hypothetical M-UNP in crystalline rock with facilities for small modular reactors, spent fuel storage, reprocessing, and geologic disposal is described using a room-and-pillar reference-design cavern. Underground construction cost is judged tractable through use of modern excavation technology and careful site selection. (authors)

  12. 77 FR 12761 - Special Regulations; Areas of the National Park System, Saguaro National Park, Bicycle Route

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-02

    ... National Park Service 36 CFR Part 7 RIN 1024-AE08 Special Regulations; Areas of the National Park System, Saguaro National Park, Bicycle Route AGENCY: National Park Service, Interior. ACTION: Proposed rule. SUMMARY: The National Park Service (NPS) is proposing to designate the Hope Camp Trail as a bicycle route...

  13. An amusement park physics competition

    NASA Astrophysics Data System (ADS)

    Moll, Rachel F.

    2010-07-01

    Amusement park physics is a popular way to reinforce physics concepts and to motivate physics learners. This article describes a novel physics competition where students use simple tools to take amusement park ride measurements and use the data to answer challenging exam questions. Research into the impact of participating in the competition reveals positive effects such as the acquisition of experimentation skills and improved attitudes towards physics.

  14. IL-19, IL-20 and IL-24: potential therapeutic targets for autoimmune diseases.

    PubMed

    Leng, Rui-Xue; Pan, Hai-Feng; Tao, Jin-Hui; Ye, Dong-Qing

    2011-02-01

    IL-19, IL-20 and IL-24 are members of the IL-10 family of cytokines, the human IL-19, IL-20 and IL-24 genes are all located on the q32 region of chromosome 1, and the three cytokines also share a common receptor IL-20R1/IL-20R2 heterodimer. These cytokines due to the similarity and shared receptor usage, are quite overlapping in function. Recently, the available evidence has indicated that interaction of these cytokines with their receptors might exhibit pro-inflammatory effects on autoimmune diseases, particularly psoriasis and rheumatoid arthritis. Since an imbalance between anti- and pro-inflammatory cytokines contribute to the development of autoimune diseases, these cytokines may be implicated in the pathogenesis of autoimmunity. In this paper, we concisely discuss the biological features of IL-19, IL-20 and IL-24, and focus on their potential roles in autoimmune diseases. Hopefully the information obtained will lead to a better understanding of the pathogenesis and development of novel therapeutic strategies for autoimmune diseases.

  15. Contribution of Public Parks to Physical Activity

    PubMed Central

    Cohen, Deborah A.; McKenzie, Thomas L.; Sehgal, Amber; Williamson, Stephanie; Golinelli, Daniela; Lurie, Nicole

    2007-01-01

    Objectives. Parks provide places for people to experience nature, engage in physical activity, and relax. We studied how residents in low-income, minority communities use public, urban neighborhood parks and how parks contribute to physical activity. Methods. In 8 public parks, we used direct observation to document the number, gender, race/ethnicity, age group, and activity level of park users 4 times per day, 7 days per week. We also interviewed 713 park users and 605 area residents living within 2 miles of each park. Results. On average, over 2000 individuals were counted in each park, and about two thirds were sedentary when observed. More males than females used the parks, and males were twice as likely to be vigorously active. Interviewees identified the park as the most common place they exercised. Both park use and exercise levels of individuals were predicted by proximity of their residence to the park. Conclusions. Public parks are critical resources for physical activity in minority communities. Because residential proximity is strongly associated with physical activity and park use, the number and location of parks are currently insufficient to serve local populations well. PMID:17267728

  16. Interleukin-6 (IL-6) production by astrocytes: autocrine regulation by IL-6 and the soluble IL-6 receptor.

    PubMed

    Van Wagoner, N J; Oh, J W; Repovic, P; Benveniste, E N

    1999-07-01

    In the CNS, astrocytes are a major inducible source of interleukin-6 (IL-6). Although IL-6 has beneficial effects in the CNS because of its neurotrophic properties, its overexpression is generally detrimental, adding to the pathophysiology associated with CNS disorders. Many factors have been shown to induce IL-6 expression by astrocytes, particularly the cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta). However, the role of IL-6 in its own regulation in astrocytes has not been determined. In this study, we examined the influence of IL-6 alone or in combination with TNF-alpha or IL-1beta on IL-6 expression. IL-6 alone had no effect on IL-6 expression; however, the addition of the soluble IL-6 receptor (sIL-6R) induced IL-6 transcripts. Addition of TNF-alpha or IL-1beta plus IL-6/sIL-6R led to synergistic increases in IL-6 expression. This synergy also occurred in the absence of exogenously added IL-6, attributable to TNF-alpha- or IL-1beta-induced endogenous IL-6 protein production. IL-6 upregulation seen in the presence of TNF-alpha or IL-1beta plus IL-6/sIL-6R was transcriptional, based on nuclear run-on analysis. Experiments were extended to other IL-6 family members to determine their role in IL-6 regulation in astrocytes. Oncostatin M (OSM) induced IL-6 alone and synergized with TNF-alpha for enhanced expression. These results demonstrate that IL-6/sIL-6R and OSM play an important role in the regulation of IL-6 expression within the CNS, particularly in conjunction with the proinflammatory cytokines TNF-alpha and IL-1beta.

  17. Effect of lubricants and a vaginal spermicide gel on the detection of prostate specific antigen, a biomarker of semen exposure, using a quantitative (Abbott ARCHITECT) assay☆, ☆☆, ★

    PubMed Central

    Snead, Margaret C.; Melendez, Johan H.; Kourtis, Athena P.; Chaney, Dorothy M.; Brown, Teresa M.; Black, Carolyn M.; Mauck, Christine K.; Schwartz, Jill L.; Zenilman, Jonathan M.; Jamieson, Denise J.; Macaluso, Maurizio; Doncel, Gustavo F.

    2015-01-01

    Objectives Little is known about the effects of commonly used lubricants on detection of biomarkers of semen exposure. We investigated the in vitro effect of Gynol®, K-Y Jelly®, Replens®, Astroglide®, Carbopol, and Silicorel on quantitative detection of prostate specific antigen (PSA). Study Design A predetermined concentration of each of the gels was added to serially diluted semen samples. Additionally, serial dilutions of each of the gels were added to three different semen dilutions (high, medium, or low). The resulting samples were tested for PSA on the Abbott ARCHITECT System. Results When using the Abbott ARCHITECT system, the only products that inhibited PSA detection were Gynol® and Replens®. The inhibition caused by Gynol® was dose-dependent, but that of Replens was dose-independent. K-Y Jelly®-spiked samples had higher PSA values than controls. Conclusions Caution is warranted when using the Abbott quantitative assay for PSA detection as a biomarker of semen exposure in settings where Gynol®, Replens® or K-Y Jelly® might also have been used. Neither Astroglide® nor Silicorel inhibited PSA detection. Additional studies evaluating other vaginal products, including microbicides, and their effects on other assays, are needed. In vivo studies will be especially important to optimize PSA detection from clinical samples. Implications Researchers should consider the potential for specific lubricants or any vaginal products to affect the particular assay used for semen biomarker detection. The Abbott ARCHITECT’s total PSA assay should not be used with the product Replens. Caution is warranted when using the assay in settings where Gynol or K-Y jelly may have been used. PMID:24314911

  18. IL-15 temporally reorients IL-10 biased B-1a cells toward IL-12 expression.

    PubMed

    Kanti Ghosh, Amlan; Sinha, Debolina; Mukherjee, Subhadeep; Biswas, Ratna; Biswas, Tapas

    2016-03-01

    Interleukin (IL)-15 is known to strongly modulate T-cell function; however, its role in controlling mucosal immunity, including its ability to modulate B-1a cell activity, remains to be elucidated. Here, we show that IL-15 upregulates activation molecules and the costimulatory molecule CD80 on viable B-1a cells. Cell activation was accompanied by the depletion of sialic acid-binding immunoglobulin-like lectin (Siglec)-G, an inhibitor of cell activation that is present on B-1a cells. The IL-15 receptor CD122 was stimulated on B-1a cells by the cytokine showing its direct involvement in IL-15-mediated responses. IL-10 is responsible for the long term survival of B-1a cells in culture, which is initially promoted by IL-15. The upregulation of IL-10 was followed by the appearance of suppressor of cytokine signaling (SOCS)1 in the presence of IL-15 and the loss of IL-10. This resulted in the cells switching to IL-12 expression. This anti-inflammatory to pro-inflammatory shift in the B-1a cell character was independent of the cell-specific marker CD5, which remained highly expressed throughout the in vitro life of the cells. The presence of the immunosuppressive receptor programmed cell death (PD)-1 and its ligand PD-L2 were features of a predominantly IL-10 response. PD-1 and PD-L2 can mediate juxtacrine signaling. However, the abrogation of PD-1 and its ligand was observed when the cells expressed IL-12. This demonstrates an inverse relationship between the receptor and ligand and the pro-inflammatory cytokine. The induction of IgM and IgA, which can play pivotal roles in mucosal immunity, was promoted in the presence of IL-15. Collectively, the data implicate IL-15 as the master cytokine that induces B-1a cells to mount a mucosal immune response.

  19. Comparison of FT4 with log TSH on the Abbott Architect ci8200: Pediatric reference intervals for free thyroxine and thyroid-stimulating hormone

    PubMed Central

    Soldin, Steven J; Cheng, Luke L; Lam, Lisa Y; Werner, Alice; Le, Alexander D; Soldin, Offie P

    2013-01-01

    Background We evaluated the clinical validity of serum FT4 measurements by assessing its correlation with log TSH. To provide pediatric reference intervals (representative ranges) for FT4, and TSH on the Architect ci8200 integrated system. Methods This population-based study encompassed 6023 children (3369 females and 2654 males). The percentile and Hoffmann approaches for obtaining reference intervals on these analytes were also compared. Results: FT4 correlation with log TSH was poor ( r=0.010 for males and 0.050 for females). Reference intervals were established. TSH and FT4 did not show a significant sex difference; moreover, the intervals decreased with age for FT4 and TSH. Conclusions Whereas in a previous study ultrafiltration tandem mass spectrometry yielded a correlation of r=0.90 for FT4 vs. log TSH this present study reveals a poor FT4 vs. log TSH correlation in the pediatric population studied and indicates the FT4 immunoassay conducted on the Abbott Architect ci8200 is less useful clinically than might have been expected. Reference intervals using the Hoffmann approach for pediatric in- and out-patients compare well with previously published results utilizing the percentile approach. PMID:19931524

  20. Age- and Gender-Specific Reference Intervals for Fasting Blood Glucose and Lipid Levels in School Children Measured With Abbott Architect c8000 Chemistry Analyzer.

    PubMed

    Tamimi, Waleed; Albanyan, Esam; Altwaijri, Yasmin; Tamim, Hani; Alhussein, Fahad

    2012-04-01

    Reference intervals for pubertal characteristics are influenced by genetic, geographic, dietary and socioeconomic factors. Therefore, the aim of this study was to establish age-specific reference intervals of glucose and lipid levels among local school children. This was cross-sectional study, conducted among Saudi school children. Fasting blood samples were collected from 2149 children, 1138 (53%) boys and 1011 (47%) girls, aged 6 to 18 years old. Samples were analyzed on the Architect c8000 Chemistry System (Abbott Diagnostics, USA) for glucose, cholesterol, triglycerides, HDL and LDL. Reference intervals were established by nonparametric methods between the 2.5th and 97.5th percentiles. Significant differences were observed between boys and girls for cholesterol and triglycerides levels in all age groups (P < 0.02). Only at age 6-7 years and at adolescents, HDL and LDL levels were found to be significant (P < 0.001). No significant differences were seen in glucose levels except at age 12 to 13 years. Saudi children have comparable serum cholesterol levels than their Western counterparts. This may reflect changing dietary habits and increasing affluence in Saudi Arabia. Increased lipid screening is anticipated, and these reference intervals will aid in the early assessment of cardiovascular and diabetes risk in Saudi pediatric populations.

  1. Field evaluation of an open and polyvalent universal HIV-1/SIVcpz/SIVgor quantitative RT-PCR assay for HIV-1 viral load monitoring in comparison to Abbott RealTime HIV-1 in Cameroon.

    PubMed

    Guichet, Emilande; Aghokeng, Avelin; Eymard-Duvernay, Sabrina; Vidal, Nicole; Ayouba, Ahidjo; Mpoudi Ngole, Eitel; Delaporte, Eric; Ciaffi, Laura; Peeters, Martine

    2016-11-01

    With the increasing demand of HIV viral load (VL) tests in resource-limited countries (RLCs) there is a need for assays at affordable cost and able to quantify all known HIV-1 variants. VLs obtained with a recently developed open and polyvalent universal HIV-1/SIVcpz/SIVgor RT-qPCR were compared to Abbott RealTime HIV-1 assay in Cameroon. On 474 plasma samples, characterized by a wide range of VLs and a broad HIV-1 group M genetic diversity, 97.5% concordance was observed when using the lower detection limit of each assay. When using the threshold of 3.00 log10 copies/mL, according to WHO guidelines to define virological failure (VF) in RLCs, the concordance was 94.7%, 360/474 versus 339/474 patients were identified with VF with the new assay and Abbott RealTime HIV-1, respectively. Higher VLs were measured with the new assay, +0.47 log10 copies/mL (95% CI; 0.42-0.52) as shown with Bland-Altman analysis. Eleven samples from patients on VF with drug resistance were not detected by Abbott RealTime HIV-1 versus two only with the new assay. Overall, our study showed that the new assay can be easily implemented in a laboratory in RLCs with VL experience and showed good performance on a wide diversity of HIV-1 group M variants.

  2. Yellowstone Lake/National Park

    NASA Image and Video Library

    1994-09-30

    STS068-247-061 (30 September-11 October 1994) --- Photographed through the Space Shuttle Endeavour's flight windows, this 70mm frame centers on Yellowstone Lake in the Yellowstone National Park. North will be at the top if picture is oriented with series of sun glinted creeks and river branches at top center. The lake, at 2,320 meters (7,732 feet) above sea level, is the largest high altitude lake in North America. East of the park part of the Absaroka Range can be traced by following its north to south line of snow capped peaks. Jackson Lake is southeast of Yellowstone Park, and the connected Snake River can be seen in the lower left corner. Yellowstone, established in 1872 is the world's oldest national park. It covers an area of 9,000 kilometers (3,500 square miles), lying mainly on a broad plateau of the Rocky Mountains on the Continental Divide. It's average altitude is 2,440 meters (8,000 feet) above sea level. The plateau is surrounded by mountains exceeding 3,600 meters (12,000 feet) in height. Most of the plateau was formed from once-molten lava flows, the last of which is said to have occurred 100,000 years ago. Early volcanic activity is still evident in the region by nearly 10,000 hot springs, 200 geysers and numerous vents found throughout the park.

  3. Model of interaction of the IL-1 receptor accessory protein IL-1RAcP with the IL-1beta/IL-1R(I) complex.

    PubMed

    Casadio, R; Frigimelica, E; Bossù, P; Neumann, D; Martin, M U; Tagliabue, A; Boraschi, D

    2001-06-15

    A preliminary model has been calculated for the activating interaction of the interleukin 1 receptor (IL-1R) accessory protein IL-1RAcP with the ligand/receptor complex IL-1beta/IL-1R(I). First, IL-1RAcP was modeled on the crystal structure of IL-1R(I) bound to IL-1beta. Then, the IL-1RAcP model was docked using specific programs to the crystal structure of the IL-1beta/IL-1R(I) complex. Two types of models were predicted, with comparable probability. Experimental data obtained with the use of IL-1beta peptides and antibodies, and with mutated IL-1beta proteins, support the BACK model, in which IL-1RAcP establishes contacts with the back of IL-1R(I) wrapped around IL-1beta.

  4. Parking Assistance Systems using Human Guidance

    NASA Astrophysics Data System (ADS)

    Wada, Massaki; Yoon, Kang Sup; Hashimoto, Hideki

    This paper dicusses the problem of parking assistance system development. Firstly, we propose the driver assistance systems general architecture based on path planning and human interface modules. A path generation method based on parking possibility area is developed for the parking assistance systems. The human interface designed for the parking assistance systems is then described. A prototype of the parking assistance systems based on the proposed architecture and approaches have been constructed. Proposed algorithms and implementation solutions in the prototype construction are described. The lane and row parking experimental results obtained with the prototype systems are also shown.

  5. Increased number of IL-2, IL-2 receptor and IL-10 positive cells in premalignant lesions of the cervix.

    PubMed

    Mindiola, Raimy; Caulejas, Diana; Núñez-Troconis, José; Araujo, Mary; Delgado, Mariela; Mosquera, Jesús

    2008-12-01

    Previous studies have shown the involvement of the immune response in the progression of human uterine cervix cancer. The aim of this study was to determine the expression of Interleukin-2 (IL-2), IL-2 receptor (IL-2R) and Interleukin 10 (IL-10) in different grades of cervical intraepithelial neoplasias of the exocervix (CIN 1, 2 and 3), and its relationship with the serum cytokine profiles and human papilomavirus (HPV) infection status. Indirect immunofluorescence was used to study the expression of IL-2, IL-2R and IL-10 in human cervical samples from 50 patients and 9 normal controls. Serum IL-2, IL-2R and IL-10 were measured by ELISA and HPV DNA and HPV types were identified by PCR. Increased number of IL-2, IL-2R and IL-10 positive cells were observed in the cervix from patients with CIN, associated with the grades of dysplasia. A significant correlation was observed between IL-2 and IL-2R (p>0.0001), IL-2 and IL-10 (p>0.0001), as well as IL-10 and IL-2R (p>0.0001). Twenty percent of patients were HPV positive and 84% of those patients were tissue cytokine positive. These results suggest that IL-2, IL-2R and IL-10 tissue expression may play a role in the development of cervical intraepithelial dysplasias.

  6. ILS Element Ell Design Influence

    DTIC Science & Technology

    1991-04-01

    and typing support were most competently provided by Barbara Boren and Denise Montanez . We gratefully acknowledge the significant contributions made to...should boot-up and the hard disk driv;e prompt (usually C :’\\) should appear on the screen. 2. Insert the copy of disk 1, ILS Assessment Software...into Drive A. ILS REVIEW SOFTWARE INSTALLATION AND BACKUP 2-3 3. After the C :\\ prompt, type "MD C :\\ILS" and press <Enter>. This creates an ILS directory

  7. Bibliography of Doctor Chul Park

    NASA Astrophysics Data System (ADS)

    Gochberg, Lawrence A.; Venkatapathy, Ethiraj; Park, Chul

    1995-05-01

    This document contains a comprehensive bibliography of the published works, and a short biography, of Dr. Chul Park. The contents of this bibliography were compiled primarily from the NASA RECON data base. The RECON citations have been modified to appear in a uniform format with all other listed citations . These other citations were located by computer searches in the INSPEC, NTIS, COMPENDEX, and Chemical Abstracts data bases, as well as through the cooperation of Dr. Chul Park, and his associates in the Reacting Flow Environments Branch at NASA Ames Research Center. All citations are presented in an approximate reverse chronological order from the present date. This work was created to honor the occasion of Dr. Chul Park's retirement on December 14, 1994, after 27 years of distinguished government service at the NASA Ames Research Center.

  8. Bibliography of Doctor Chul Park

    NASA Technical Reports Server (NTRS)

    Gochberg, Lawrence A.; Venkatapathy, Ethiraj; Park, Chul

    1995-01-01

    This document contains a comprehensive bibliography of the published works, and a short biography, of Dr. Chul Park. The contents of this bibliography were compiled primarily from the NASA RECON data base. The RECON citations have been modified to appear in a uniform format with all other listed citations . These other citations were located by computer searches in the INSPEC, NTIS, COMPENDEX, and Chemical Abstracts data bases, as well as through the cooperation of Dr. Chul Park, and his associates in the Reacting Flow Environments Branch at NASA Ames Research Center. All citations are presented in an approximate reverse chronological order from the present date. This work was created to honor the occasion of Dr. Chul Park's retirement on December 14, 1994, after 27 years of distinguished government service at the NASA Ames Research Center.

  9. Perceived Health Benefits and Willingness to Pay for Parks by Park Users: Quantitative and Qualitative Research

    PubMed Central

    Henderson-Wilson, Claire; Sia, Kah-Ling; Veitch, Jenny; Staiger, Petra K; Davidson, Penny; Nicholls, Peter

    2017-01-01

    Whilst a growing body of evidence demonstrates people derive a range of health and wellbeing benefits from visiting parks, only a limited number of attempts have been made to provide a complementary economic assessment of parks. The aim of this exploratory study was to directly estimate the perceived health and wellbeing benefits attained from parks and the economic value assigned to parks by park users in Victoria, Australia. The research employed a mixed methods approach (survey and interviews) to collect primary data from a selection of 140 park users: 100 from two metropolitan parks in Melbourne and 40 from a park on the urban fringe of Melbourne, Victoria. Our findings suggest that park users derive a range of perceived physical, mental/spiritual, and social health benefits, but park use was predominantly associated with physical health benefits. Overall, our exploratory study findings suggest that park users are willing to pay for parks, as they highly value them as places for exercising, socialising, and relaxing. Importantly, most people would miss parks if they did not exist. The findings aim to provide park managers, public health advocates, and urban policy makers with evidence about the perceived health and wellbeing benefits of park usage and the economic value park visitors place on parks. PMID:28505123

  10. Perceived Health Benefits and Willingness to Pay for Parks by Park Users: Quantitative and Qualitative Research.

    PubMed

    Henderson-Wilson, Claire; Sia, Kah-Ling; Veitch, Jenny; Staiger, Petra K; Davidson, Penny; Nicholls, Peter

    2017-05-15

    Whilst a growing body of evidence demonstrates people derive a range of health and wellbeing benefits from visiting parks, only a limited number of attempts have been made to provide a complementary economic assessment of parks. The aim of this exploratory study was to directly estimate the perceived health and wellbeing benefits attained from parks and the economic value assigned to parks by park users in Victoria, Australia. The research employed a mixed methods approach (survey and interviews) to collect primary data from a selection of 140 park users: 100 from two metropolitan parks in Melbourne and 40 from a park on the urban fringe of Melbourne, Victoria. Our findings suggest that park users derive a range of perceived physical, mental/spiritual, and social health benefits, but park use was predominantly associated with physical health benefits. Overall, our exploratory study findings suggest that park users are willing to pay for parks, as they highly value them as places for exercising, socialising, and relaxing. Importantly, most people would miss parks if they did not exist. The findings aim to provide park managers, public health advocates, and urban policy makers with evidence about the perceived health and wellbeing benefits of park usage and the economic value park visitors place on parks.

  11. Lichens of the U. S. national parks

    USGS Publications Warehouse

    Bennett, J.P.; Wetmore, C.M.

    2005-01-01

    Over 26,100 records of lichens present in 144 U.S. national park units were assembled from various sources into a database and analyzed. Within these 144 park units 2,435 species and 375 genera are reported, representing 63% and 74% of the North American flora, respectively. The park units are located in 41 states and Washington, D.C. The average number of species in a park is 104, but the median is 60, indicating there are many parks with a small number of species and a few with high numbers. Isle Royale National Park has the most species, 611, and twelve parks have only one species reported. The number of records of lichens present ranged from one for 25 parks, to 1,623 for Isle Royale. Physcia aipolia is the most frequently observed species, being found in 65 parks. One fourth of the park units are classified cultural resource parks, while the remainder are considered natural resource parks. This study was based on 453 sources, including literature citations, park reports and collections in the University of Minnesota Herbarium. Copyright ?? 2005 by the American Bryological and Lichenological Society, Inc.

  12. Evaluation of the performance of Abbott m2000 and Roche COBAS Ampliprep/COBAS Taqman assays for HIV-1 viral load determination using dried blood spots and dried plasma spots in Kenya

    PubMed Central

    Ndiege, Kenneth; Inzaule, Seth; Achieng, Rebecca; Williamson, John; Chih-Wei Chang, Joy; Ellenberger, Dennis; Nkengasong, John

    2017-01-01

    Background Routine HIV viral load testing is not widely accessible in most resource-limited settings, including Kenya. To increase access to viral load testing, alternative sample types like dried blood spots (DBS), which overcome the logistic barriers associated with plasma separation and cold chain shipment need to be considered and evaluated. The current study evaluated matched dried blood spots (DBS) and dried plasma spots (DPS) against plasma using the Abbott M 2000 (Abbott) and Roche Cobas Ampliprep/Cobas TaqMan (CAP/CTM) quantitative viral load assays in western Kenya. Methods Matched plasma DBS and DPS were obtained from 200 HIV-1 infected antiretroviral treatment (ART)-experienced patients attending patient support centers in Western Kenya. Standard quantitative assay performance parameters with accompanying 95% confidence intervals (CI) were assessed at the assays lower detection limit (400cps/ml for CAP/CTM and 550cps/ml for Abbott) using SAS version 9.2. Receiver operating curves (ROC) were further used to assess viral-load thresholds with best assay performance (reference assay CAP/CTM plasma). Results Using the Abbott test, the sensitivity and specificity, respectively, for DPS were (97.3%, [95%CI: 93.2–99.2] and 98.1% [95%CI: 89.7–100]) and those for DBS (93.9% [95%CI: 88.8–97.2] and 88.0% [95%CI: 82.2–92.4]). The correlation and agreement using paired plasma and DPS/DBS were strong, with r2 = 90.5 and rc = 68.1. The Bland-Altman relative percent change was 95.3 for DPS, (95%CI: 90.4–97.7) and 73.6 (95%CI: 51.6–86.5) for DBS. Using the CAP/CTM assay, the sensitivity for DBS was significantly higher compared to DPS (100.0% [95% CI: 97.6–100.0] vs. 94.7% [95%CI: 89.8–97.7]), while the specificity for DBS was lower: 4%, [95% CI: 0.4–13.7] compared to DPS: 94.0%, [95% CI: 83.5–98.7]. When compared under different clinical relevant thresholds, the accuracy for the Abbott assay was 95% at the 1000cps/ml cut-off with a sensitivity and

  13. Everglades National Park Including Biscayne National Park. Activity Book.

    ERIC Educational Resources Information Center

    Ruehrwein, Dick

    Intended to help elementary school children learn about the resources of the Everglades and Biscayne National Parks, this activity book includes information, puzzles, games, and quizzes. The booklet deals with concepts related to: (1) the seasons; (2) fire ecology; (3) water; (4) fish; (5) mammals; (6) mosquitos; (7) birds; (8) venomous snakes;…

  14. Everglades National Park Including Biscayne National Park. Activity Book.

    ERIC Educational Resources Information Center

    Ruehrwein, Dick

    Intended to help elementary school children learn about the resources of the Everglades and Biscayne National Parks, this activity book includes information, puzzles, games, and quizzes. The booklet deals with concepts related to: (1) the seasons; (2) fire ecology; (3) water; (4) fish; (5) mammals; (6) mosquitos; (7) birds; (8) venomous snakes;…

  15. IL-1beta, IL-6 and IL-8 levels in gyneco-obstetric infections.

    PubMed Central

    Basso, Beatriz; Giménez, Francisco; López, Carlos

    2005-01-01

    OBJECTIVE: During pregnancy cytokines and inflammatory mediators stimulate the expression of prostaglandin, the levels of which determine the onset of labor. The aim of this work was to study interleukin IL-1beta, IL-6 and IL-8 levels in the vaginal discharge, serum and urine of pregnant women with genitourinary infection before and after specific treatment. One hundred and fifty-one patients were studied during the second or third trimester of their pregnancy. METHODS: The selected patients were: healthy or control group (n = 52), those with bacterial vaginosis (n = 47), those with vaginitis (n = 37), those with asymptomatic urinary infection (n = 15) and post-treatment. The level of cytokines was assayed by ELISA test. The Mann-Whitney U-test was used for statistical analysis. RESULTS: The IL-1beta levels in vaginal discharge were: control 103.5 +/- 24.2 pg/ml, bacterial vaginosis 1030 +/- 59.5, vaginitis 749.14 +/- 66.7l ( p < 0.0001), post-treatment 101.4 +/- 28.7. IL-6 values were similar in both control and infected groups, and there were no patients with chorioamnionitis. In vaginal discharge IL-6: control 14.2 +/- 3.9 pg/ml, bacterial vaginosis 13.2 +/- 3.8, vaginitis 13 +/- 4.2. IL-8 levels were: control 1643 +/- 130.3 pg/ml, bacterial vaginosis 2612.7 +/- 257.7, vaginitis 3437 +/- 460 (p < 0.0001), post-treatment 1693 +/- 126.6. In urine the results were: control 40.2 +/- 17 pg/ml, asymptomatic urinary infection 1200.7 +/- 375 (p < 0.0001). In patients with therapeutic success both IL-1beta and IL-8 returned to normal levels. CONCLUSIONS: Genitourinary infections induce a significant increase in IL-1beta and IL-8 levels in vaginal secretions, and IL-8 in urine as well. Both cytokines could be useful as evolutive markers of infection. PMID:16338780

  16. Role of IL-18 in atopic asthma is determined by balance of IL-18/IL-18BP/IL-18R.

    PubMed

    Zhang, Huiyun; Wang, Junling; Wang, Ling; Xie, Hua; Chen, Liping; He, Shaoheng

    2017-09-18

    It is recognized that IL-18 is related to development of asthma, but role of IL-18 in asthma remains controversial and confusing. This is largely due to lack of information on expression of IL-18 binding protein (BP) and IL-18 receptor (R) in asthma. In this study, we found that plasma levels of IL-18 and IL-18BP were elevated in asthma. The ratio between plasma concentrations of IL-18 and IL-18BP was 1:12.8 in asthma patients. We demonstrated that 13-fold more monocytes, 17.5-fold more neutrophils and 4.1-fold more B cells express IL-18BP than IL-18 in asthmatic blood, suggesting that there is excessive amount of IL-18BP to abolish actions of IL-18 in asthma. We also discovered that more IL-18R+ monocytes, neutrophils and B cells are located in asthmatic blood. Once injected, IL-18 eliminated IL-18R+ monocytes in blood, but up-regulated expression of IL-18R in lung macrophages of OVA-sensitized mice. Our data clearly indicate that the role of IL-18 in asthma is very likely to be determined by balance of IL-18/IL-18BP/IL-18R expression in inflammatory cells. Therefore, IL-18R blocking or IL-18BP activity enhancing therapies may be useful for treatment of asthma. © 2017 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

  17. IL-1β Suppresses Innate IL-25 and IL-33 Production and Maintains Helminth Chronicity

    PubMed Central

    Zaiss, Mario M.; Maslowski, Kendle M.; Mosconi, Ilaria; Guenat, Nadine; Marsland, Benjamin J.; Harris, Nicola L.

    2013-01-01

    Approximately 2 billion people currently suffer from intestinal helminth infections, which are typically chronic in nature and result in growth retardation, vitamin A deficiency, anemia and poor cognitive function. Such chronicity results from co-evolution between helminths and their mammalian hosts; however, the molecular mechanisms by which these organisms avert immune rejection are not clear. We have found that the natural murine helminth, Heligmosomoides polygyrus bakeri (Hp) elicits the secretion of IL-1β in vivo and in vitro and that this cytokine is critical for shaping a mucosal environment suited to helminth chronicity. Indeed in mice deficient for IL-1β (IL-1β−/−), or treated with the soluble IL-1βR antagonist, Anakinra, helminth infection results in enhanced type 2 immunity and accelerated parasite expulsion. IL-1β acts to decrease production of IL-25 and IL-33 at early time points following infection and parasite rejection was determined to require IL-25. Taken together, these data indicate that Hp promotes the release of host-derived IL-1β that suppresses the release of innate cytokines, resulting in suboptimal type 2 immunity and allowing pathogen chronicity. PMID:23935505

  18. America's National Parks 3d (4)

    Atmospheric Science Data Center

    2017-04-11

    article title:  America's National Parks Viewed in 3D by NASA's MISR (Anaglyph 4)   ... four new anaglyphs that showcase 33 of our nation's national parks, monuments, historical sites and recreation areas in glorious 3D.   ...

  19. America's National Parks 3d (3)

    Atmospheric Science Data Center

    2016-12-30

    article title:  America's National Parks Viewed in 3D by NASA's MISR (Anaglyph 3)   ... four new anaglyphs that showcase 33 of our nation's national parks, monuments, historical sites and recreation areas in glorious 3D.   ...

  20. America's National Parks 3d (2)

    Atmospheric Science Data Center

    2016-12-30

    article title:  America's National Parks Viewed in 3D by NASA's MISR (Anaglyph 2)   ... four new anaglyphs that showcase 33 of our nation's national parks, monuments, historical sites and recreation areas in glorious 3D.   ...

  1. America's National Parks 3d (1)

    Atmospheric Science Data Center

    2016-12-30

    article title:  America's National Parks Viewed in 3D by NASA's MISR (Anaglyph 1)   ... four new anaglyphs that showcase 33 of our nation's national parks, monuments, historical sites and recreation areas in glorious 3D.   ...

  2. PARK2 Mediates Interleukin 6 and Monocyte Chemoattractant Protein 1 Production by Human Macrophages

    PubMed Central

    de Léséleuc, Louis; Girard, Manon; Huong, Nguyen Thu; Ba, Nguyen Ngoc; Van Thuc, Nguyen; Truman, Richard; Spencer, John S.; Adams, Linda; Thai, Vu Hong; Alcais, Alexandre; Schurr, Erwin

    2013-01-01

    Leprosy is a persistent infectious disease caused by Mycobacterium leprae that still affects over 200,000 new patients annually. The host genetic background is an important risk factor for leprosy susceptibility and the PARK2 gene is a replicated leprosy susceptibility candidate gene. The protein product of PARK2, Parkin, is an E3 ubiquitin ligase that is involved in the development of various forms of Parkinsonism. The human macrophage is both a natural host cell of M. leprae as well as a primary mediator of natural immune defenses, in part by secreting important pro-inflammatory cytokines and chemokines. Here, we report that down-regulation of Parkin in THP-1 macrophages, human monocyte-derived macrophages and human Schwann cells resulted in a consistent and specific decrease in interleukin-6 (IL-6) and monocyte chemoattractant protein 1 (MCP-1/CCL2) production in response to mycobacteria or LPS. Interestingly, production of IL-6 at 6 hours by THP-1 cells stimulated with live M. leprae and M. bovis BCG was dependent on pretreatment with 1,25-dihydroxyvitamin D3 (VD). Parkin knockdown in VD-treated cells blocked IL-6 induction by mycobacteria. However, IκB-α phosphorylation and levels of IκB-ξ, a nuclear protein required for IL-6 expression, were not affected by Parkin silencing. Phosphorylation of MAPK ERK1/2 and p38 was unaffected by Parkin silencing while JNK activation was promoted but did not explain the altered cytokine production. In a final set of experiments we found that genetic risk factors of leprosy located in the PARK2 promoter region were significantly correlated with M. leprae sonicate triggered CCL2 and IL6 transcript levels in whole blood assays. These results associated genetically controlled changes in the production of MCP-1/CCL2 and IL-6 with known leprosy susceptibility factors. PMID:23350010

  3. Park-based physical activity in diverse communities of two U.S. cities. An observational study.

    PubMed

    Floyd, Myron F; Spengler, John O; Maddock, Jason E; Gobster, Paul H; Suau, Luis J

    2008-04-01

    Systematic study of human behavior in public parks and specific activity settings can inform policy to promote physical activity in diverse communities. Direct observation was used to assess physical activity in public parks in Tampa FL (n=10) and Chicago IL (n=18). Parks were selected from census tracts with high concentrations of white, African-American, and Hispanic populations. Representation from low- and high-income census tracts was also achieved. Physical activity was measured by a modified version of the System for Observing Play and Leisure Activity in Youth (SOPLAY). Activity codes from SOPLAY were transformed to energy expenditure per person (kcal/kg/min). Seventy percent of Tampa and 51% of Chicago park users were observed engaged in sedentary behavior. In both cities, children were more likely than adults to be observed in walking or vigorous activity. In Tampa, parks located in neighborhoods with the highest concentration of Hispanic residents were associated with greatest levels of energy expenditure. In Chicago, parks in neighborhoods with the highest concentration of African Americans showed the highest energy expenditure per person. Gender was associated with physical activity only in Tampa parks. Energy expenditure also varied by activity areas. More than one half of park users in both cities engaged in sedentary behavior. While differences in park-based physical activity by neighborhood income and racial/ethnic composition were observed, these differences can more likely be attributed to the types of designated activity areas that support physical activity. The study findings suggest that specific configurations of park environments can enhance physical activity in parks.

  4. Accessibility and usability of parks and playgrounds.

    PubMed

    Perry, Meredith A; Devan, Hemakumar; Fitzgerald, Harry; Han, Karen; Liu, Li-Ting; Rouse, Jack

    2017-09-08

    Public parks and playgrounds are an environment for leisure activity, which all generations can enjoy at low or no financial cost. Evaluating the accessibility and usability of parks and playgrounds is crucial because their design, environment (natural and built) and safety could restrict participation of persons with disabilities. To evaluate the accessibility and usability of 21 public parks and playgrounds in three metropolitan cities of New Zealand. Secondary aims were to compare the accessibility and usability by park type (destination or neighborhood) and deprivation level (high and low). Twenty-one parks were evaluated. A stratified random sampling was used to select 18 parks (six from each city). Three additional parks were purposely selected (one from each city) at the request of each respective city council. The parks and playgrounds were evaluated using a customized tool. Data were analyzed using descriptive statistics. None of the parks we evaluated met the national standards and/or international guidelines for park and playground design. We identified potential accessibility and usability issues with car parking spaces, path surfaces and play equipment as well as lack of lighting and fencing. The presence of amenities (e.g. toilets and drinking fountains) was more common in destination parks. Fewer parks in areas of higher deprivation had accessible car parking spaces and main paths wider than 1.5 m. Our evaluation identified potential design, environmental and safety barriers to park and playground based participation for persons with disabilities across the lifespan. A larger, more comprehensive evaluation of parks and playgrounds is required. Copyright © 2017. Published by Elsevier Inc.

  5. The First National Study of Neighborhood Parks

    PubMed Central

    Cohen, Deborah A.; Han, Bing; Nagel, Catherine; Harnik, Peter; McKenzie, Thomas L.; Evenson, Kelly R.; Marsh, Terry; Williamson, Stephanie; Vaughan, Christine; Katta, Sweatha

    2016-01-01

    Introduction An extensive infrastructure of neighborhood parks supports leisure time physical activity in most U.S. cities; yet, most Americans do not meet national guidelines for physical activity. Neighborhood parks have never been assessed nationally to identify their role in physical activity. Methods Using a stratified multistage sampling strategy, a representative sample of 174 neighborhood parks in 25 major cities (population >100,000) across the U.S. was selected. Park use, park-based physical activity, and park conditions were observed during a typical week using systematic direct observation during spring/summer of 2014. Park administrators were interviewed to assess policies and practices. Data were analyzed in 2014–2015 using repeated-measure negative binomial regressions to estimate weekly park use and park-based physical activity. Results Nationwide, the average neighborhood park of 8.8 acres averaged 23 users/hour or an estimated 1,533 person hours of weekly use. Walking loops and gymnasia each generated 221 hours/week of moderate to vigorous physical activity. Seniors represented 4% of park users, but 20% of the general population. Parks were used less in low-income than in high-income neighborhoods, largely explained by fewer supervised activities and marketing/outreach efforts. Programming and marketing were associated with 37% and 63% more hours of moderate to vigorous physical activity/week in parks, respectively. Conclusions The findings establish national benchmarks for park use, which can guide future park investments and management practices to improve population health. Offering more programming, using marketing tools like banners and posters, and installing facilities like walking loops may help currently underutilized parks increase population physical activity. PMID:27209496

  6. IL-24 transgenic mice: in vivo evidence of overlapping functions for IL-20, IL-22, and IL-24 in the epidermis.

    PubMed

    He, Miao; Liang, Peng

    2010-02-15

    IL-20 and IL-24 share two different heterodimeric receptors consisting of either IL-20R1 or IL-22R1 and a common IL-20R2 subunit, whereas IL-22 signals through IL-22R1/IL-10R2. However, until now, only IL-20 and IL-22 have been proven to play important roles in vivo in the epidermis where all four receptor subunits are expressed. In this study, we show that IL-24 transgenic mice manifest many similar phenotypes to that of IL-20 and IL-22, including neonatal lethality, epidermal hyperplasia, and abnormality in keratinocyte differentiation. These results support a largely redundant role in epidermal functions for IL-20, IL-22, and IL-24, which seem to be IL-22R1 dependent. Moreover, we show that IL-24 transgenic mice exhibit infiltrating macrophages in the dermis with concomitant increases in MCP-1 production from both keratinocytes in the epidermis and immune infiltrates in the adjacent dermal layer below. Furthermore, we demonstrate that the homodimeric IL-20R2 soluble receptor is a potent blocker for IL-24 and can be used to further dissect the crosstalk among the IL-20 family of cytokines in normal development as well as in autoimmune diseases.

  7. The impact of park development on the lives of local inhabitants within Gros Morne National Park

    Treesearch

    Margot Herd; Paul. Heintzman

    2012-01-01

    The creation of a national park changes the local community's relationship to the land. In 1973, Parks Canada created Gros Morne National Park around existing communities and only relocated a small number of inhabitants to nearby communities. While park creation placed some restrictions on traditional activities, compromises were made to allow the continuation of...

  8. Comparison of the analytical and clinical performances of Abbott RealTime High Risk HPV, Hybrid Capture 2, and DNA Chip assays in gynecology patients.

    PubMed

    Park, Seungman; Kang, Youjin; Kim, Dong Geun; Kim, Eui-Chong; Park, Sung Sup; Seong, Moon-Woo

    2013-08-01

    The detection of high-risk (HR) HPV in cervical cancer screening is important for early diagnosis of cervical cancer or pre-cancerous lesions. We evaluated the analytical and clinical performances of 3 HR HPV assays in Gynecology patients. A total of 991 specimens were included in this study: 787 specimens for use with a Hybrid Capture 2 (HC2) and 204 specimens for a HPV DNA microarray (DNA Chip). All specimens were tested using an Abbott RealTime High Risk HPV assay (Real-time HR), PGMY PCR, and sequence analysis. Clinical sensitivities for severe abnormal cytology (severe than high-grade squamous intraepithelial lesion) were 81.8% for Real-time HR, 77.3% for HC2, and 66.7% for DNA Chip, and clinical sensitivities for severe abnormal histology (cervical intraepithelial neoplasia grade 2+) were 91.7% for HC2, 87.5% for Real-time HR, and 73.3% for DNA Chip. As compared to results of the sequence analysis, HC2, Real-time HR, and DNA Chip showed concordance rates of 94.3% (115/122), 90.0% (117/130), and 61.5% (16/26), respectively. The HC2 assay and Real-time HR assay showed comparable results to each other in both clinical and analytical performances, while the DNA Chip assay showed poor clinical and analytical performances. The Real-time HR assay can be a good alternative option for HR HPV testing with advantages of allowing full automation and simultaneous genotyping of HR types 16 and 18.

  9. Evaluation of human papillomavirus detection by Abbott m2000 system on samples collected by FTA Elute™ Card in a Chinese HIV-1 positive population.

    PubMed

    Qin, Yu; Zhang, Hongyun; Marlowe, Natalia; Fei, Mandong; Yu, Judy; Lei, Xiaoqin; Yu, Lulu; Zhang, Jia; Cao, Di; Ma, Li; Chen, Wen

    2016-12-01

    HIV+/AIDS women have an increased risk of developing into CIN and cervical cancer compared to the general population. Limited medical resource and the lack of AIDS relevant knowledge impair the coverage and efficiency of cervical cancer screening. To compare the clinical performance of self-collected dry storage medium (FTA Elute card) and physician-collected PreservCyt medium in detection of high risk human papillomavirus (HR HPV) among HIV-1 positive population. Three hundred HIV-1 positive women (aged 25-65) were recruited from Yunnan infectious hospital. Two cervicovaginal samples were collected from each participant: one was collected by the women themselves and applied on a FTA Elute card; the other one was collected by a physician and stored in PreservCyt solution. All the samples were tested for 14 HR HPV using Abbott RealTime High Risk HPV assay. Biopsies were taken for histological diagnosis if any abnormal impression was noticed under colposcopy. 291 (97.0%) of participants were eligible for this study. 101 (34.70%) participants were found HR HPV positive in both FTA card and PreservCyt samples, and 19 (6.53%) women were diagnosed as CIN2+. The HR HPV positive rate on samples collected by FTA Elute card and PreservCyt solution was 42.61% and 39.86%, respectively. The overall agreement was 87% (kappa=0.731) between FTA card and PreservCyt. The clinical sensitivity and specificity of FTA card and PreservCyt were 100%, 61.39% and 100%, 64.33%, respectively. In this study, FTA Elute card demonstrated a good performance on self-collected sample for HR HPV detection in HIV-1 positive population. For the women from low-resource area with HIV-1 infection, FTA Elute card could be an attractive sample collection method for cervical cancer screening. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. Identification of early HIV infections using the fourth generation Abbott ARCHITECT HIV Ag/Ab Combo chemiluminescent microparticle immunoassay (CIA) in San Diego County.

    PubMed

    Manlutac, Anna Liza M; Giesick, Jill S; McVay, Patricia A

    2013-12-01

    HIV screening assays have gone through several generations of development in an effort to narrow the "window period" of detection. Utilizing a fourth generation HIV screening assay has the potential to detect earlier HIV infection, thus reducing HIV-1 transmission. To identify acute infections to decrease HIV transmission in San Diego County. Serum specimens were collected from clients seen by multiple submitters in San Diego County. All acceptable specimens were screened using the 4th Gen Combo Assay. Initially reactive specimens were repeated in duplicate and if repeatedly reactive, were confirmed by HIV-1 Immunofluorescent Antibody Assay (IFA). IFA negative/inconclusive specimens were sent for HIV-1 NAT and HIV-2 antibody testing to referral laboratories. BioRad Multispot HIV-1/HIV-2 Rapid Test was also performed on a subset of specimens. Of 14,559 specimens received in 20 months, 14,517 specimens were tested. Of the 14,517 specimens that were tested, a total of 279 (1.9%) specimens were CIA repeatedly reactive and 240 of the 279 confirmed by HIV-1 IFA. Thirty-nine gave IFA negative/inconclusive result and 30 were further tested for HIV-1 NAT and 36 for HIV-2 antibody. Thirteen specimens were considered false positives by CIA and 17 specimens were classified as acute infections. Eleven of 39 IFA negative/inconclusive specimens were further tested by Multispot. Five of the 11 were positive by Multispot. The fourth generation Abbott ARCHITECT HIV Ag/Ab Combo Assay identified 17 patients who may have been missed by the prior HIV-1 screening assay used at San Diego County Public Health Laboratory. Copyright © 2013 Elsevier B.V. All rights reserved.

  11. Multi-center evaluation of the Abbott RealTime HCV assay for monitoring patients undergoing antiviral therapy for chronic hepatitis C.

    PubMed

    Vermehren, Johannes; Yu, Ming-Lung; Monto, Alexander; Yao, Joseph D; Anderson, Christopher; Bertuzis, Rasa; Schneider, George; Sarrazin, Christoph

    2011-10-01

    Hepatitis C virus (HCV) RNA monitoring during antiviral therapy is essential for early prediction of treatment success and failure to peginterferon alfa/ribavirin (PEG-IFN/RBV) therapy. In this multi-center study we assessed the clinical utility of the Abbott RealTime HCV assay for monitoring patients undergoing antiviral therapy for chronic infection with HCV genotypes (GT) 1-3. We analyzed serum from 361 patients with chronic hepatitis C who had been treated with PEG-IFN/RBV. The predictive value of rapid virologic response (RVR), partial (≥2log(10) decline) and complete (HCV-RNA undetectable) early virologic response (pEVR/cEVR) based on RealTime HCV for achieving sustained virologic response was evaluated. In addition, the utility of RealTime HCV to tailor treatment duration according to individual virologic responses was studied in a subset of 136 GT 1 patients and compared to the reference tests, Versant HCV Quantitative 3.0 (bDNA) and Qualitative (TMA) assay. At week 4 of therapy, patients with RVR had a 100% and 93.5% probability to achieve an SVR in GT 1 and GT 2/3 patients, respectively. At week 12, patients who did not achieve a pEVR had a 97.2% and 100% probability of not achieving an SVR. In addition, assignment of GT 1 patients to abbreviated or extended treatment durations based on low baseline HCV-RNA (<800,000IU/mL) and RVR or pEVR was highly concordant between RealTime HCV and bDNA/TMA assays (97.8% and 91.9%, respectively). The RealTime HCV assay is suitable for monitoring virologic response to PEG-INF/RBV therapy and tailoring treatment duration accordingly. Copyright © 2011 Elsevier B.V. All rights reserved.

  12. STS-130 Nationals Park Visit

    NASA Image and Video Library

    2010-04-20

    NASA STS-130 crew Commander George Zamka, far left, Pilot Terry Virts, Mission Specialists Kathryn Hire, Stephen Robinson, Nicholas Patrick and Robert Behnken, far right, pose for pictures on the field at Nationals Park, Tuesday, April 20, 2010, in Washington. Photo Credit: (NASA/Carla Cioffi)

  13. Coltsville National Historical Park Act

    THOMAS, 112th Congress

    Sen. Lieberman, Joseph I. [ID-CT

    2011-07-12

    Senate - 10/19/2011 Committee on Energy and Natural Resources Subcommittee on National Parks. Hearings held. With printed Hearing: S.Hrg. 112-224. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  14. Designing an Amusement Park Ride

    ERIC Educational Resources Information Center

    Kurz, Terri L.; Robles, Rolando

    2016-01-01

    To improve access to STEM curriculum, an activity was planned that presents the opportunity to design and build using gears and other tools. In this challenge, preservice elementary school teachers were asked to mathematically analyze gears and create an amusement park ride that uses gears to spin. Although this lesson was implemented with…

  15. STS-130 Nationals Park Visit

    NASA Image and Video Library

    2010-04-20

    NASA STS-130 crew pose with Winter Olympics medalist Apolo Ohno, center, at Nationals Park, Tuesday, April 20, 2010, in Washington. Pictured from left are STS-130 Mission Specialist Robert Benhken, Mission Specialist Nicholas Patrick, Commander George Zamka, Apolo Ohno, Mission Specialist Stephen Robinson, Mission Specialist Kathryn Hire and Pilot Terry Virts. Photo Credit: (NASA/Carla Cioffi)

  16. Designing an Amusement Park Ride

    ERIC Educational Resources Information Center

    Kurz, Terri L.; Robles, Rolando

    2016-01-01

    To improve access to STEM curriculum, an activity was planned that presents the opportunity to design and build using gears and other tools. In this challenge, preservice elementary school teachers were asked to mathematically analyze gears and create an amusement park ride that uses gears to spin. Although this lesson was implemented with…

  17. Symmetry in the Car Park

    ERIC Educational Resources Information Center

    Hancock, Karen

    2007-01-01

    In this article, the author presents a lesson on rotational symmetry which she developed for her students. The aim of the lesson was "to identify objects with rotational symmetry in the staff car park" and the success criteria were "pictures or sketches of at least six objects with different orders of rotation". After finding examples of…

  18. Egmont National Park, New Zealand

    NASA Technical Reports Server (NTRS)

    2002-01-01

    The lush forests of Egmont National Park, on New Zealand's North Island, contrast with the pasturelands outside the circular park boundaries. The unique shape of the park results from its first protection in 1881, which specified that a forest reserve would extend in a 9.6 km radius from the summit of Mt. Taranaki (named Mt. Egmont by Captain Cook). The park covers about 33,500 hectares and Mt. Egmont stands at 2518 m. The volcano began forming 70,000 years ago, and last erupted in 1755. A series of montane habitats occur in procession up the flanks of the volcano-from rainforest, to shrubs, to alpine, and finally snow cover. Image STS110-726-6, was taken by Space Shuttle crewmembers on 9 April 2002 using a Hasselblad film camera. Image provided by the Earth Sciences and Image Analysis Laboratory at Johnson Space Center. Additional images taken by astronauts and cosmonauts can be viewed at the NASA-JSC Gateway to Astronaut Photography of Earth.

  19. 'Shockley park' stirs racism row

    NASA Astrophysics Data System (ADS)

    Gwynne, Peter

    2009-07-01

    A local authority in Northern California has encountered unexpected resistance to its decision to name a park after the Nobel-prize-winning physicist William Shockley, with a coalition of churches and civic groups preparing to petition against the name at a meeting scheduled for 23 July.

  20. Parking garage threats and countermeasures.

    PubMed

    Clark, Sam

    2004-01-01

    Preventing and dealing with crime in hospital parking facilities poses a serious challenge to administration and security. Multiple methods to effectively combat the threats are described by the author, but their implementation depends on how seriously a healthcare organization views its responsibility to provide a safe and secure environment for its staff, patients and visitors.

  1. Coltsville National Historical Park Act

    THOMAS, 113th Congress

    Sen. Blumenthal, Richard [D-CT

    2013-03-19

    04/23/2013 Committee on Energy and Natural Resources Subcommittee on National Parks. Hearings held. With printed Hearing: S.Hrg. 113-27. (All Actions) Notes: For further action, see H.R.3979, which became Public Law 113-291 on 12/19/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  2. Coltsville National Historical Park Act

    THOMAS, 112th Congress

    Sen. Lieberman, Joseph I. [ID-CT

    2011-07-12

    10/19/2011 Committee on Energy and Natural Resources Subcommittee on National Parks. Hearings held. With printed Hearing: S.Hrg. 112-224. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  3. Symmetry in the Car Park

    ERIC Educational Resources Information Center

    Hancock, Karen

    2007-01-01

    In this article, the author presents a lesson on rotational symmetry which she developed for her students. The aim of the lesson was "to identify objects with rotational symmetry in the staff car park" and the success criteria were "pictures or sketches of at least six objects with different orders of rotation". After finding examples of…

  4. Coltsville National Historical Park Act

    THOMAS, 113th Congress

    Sen. Blumenthal, Richard [D-CT

    2013-03-19

    04/23/2013 Committee on Energy and Natural Resources Subcommittee on National Parks. Hearings held. With printed Hearing: S.Hrg. 113-27. (All Actions) Notes: For further action, see H.R.3979, which became Public Law 113-291 on 12/19/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  5. Coltsville National Historical Park Act

    THOMAS, 112th Congress

    Sen. Lieberman, Joseph I. [ID-CT

    2011-07-12

    10/19/2011 Committee on Energy and Natural Resources Subcommittee on National Parks. Hearings held. With printed Hearing: S.Hrg. 112-224. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  6. Rosa Parks: The Movement Organizes.

    ERIC Educational Resources Information Center

    Friese, Kai

    This biography for younger readers describes the life of Rosa Parks, the Alabama black woman whose refusal to give up her seat on a segregated bus helped establish the civil rights movement. The book is introduced by an overview of the movement by Andrew Young and a timeline indicating major historical events from 1954 through 1968. Highlights in…

  7. National Zoological Park Branch Library.

    ERIC Educational Resources Information Center

    Kenyon, Kay A.

    1988-01-01

    Describes the functions of the National Zoological Park Branch of the Smithsonian Institution Libraries, which is dedicated to supporting the special information needs of the zoo. Topics covered include the library's history, collection, programs, services, future plans, and relations with other zoo libraries. (two references) (Author/CLB)

  8. The IL-23/IL-17 Axis in Psoriatic Arthritis

    PubMed Central

    Suzuki, Erika; Mellins, Elizabeth D.; Gershwin, M. Eric; Nestle, Frank O.; Adamopoulos, Iannis E.

    2014-01-01

    Psoriatic arthritis (PsA) is an immune-mediated chronic inflammatory disease, affecting both the skin and joints. Disease progression is associated with aberrant cytokine expression, and TNF blockade is the most successful therapy to date. However, not all patients are responsive to anti-TNF treatment, highlighting the need to better understand the cellular and molecular mechanisms that govern the disease. PsA associations with single nucleotide polymorphisms in IL23R as well as TRAF3IP2 (Act1), a molecule downstream of the IL-17 receptor (IL-17R), have linked the IL-23/IL-17 axis to disease pathology. Although both cytokines are implicated in PsA, a full picture of their cellular targets and pathogenic mechanisms has not yet emerged. In this review, we focus on the IL-23/IL-17 axis-elicited responses mediated by osteoclasts, keratinocytes and neutrophils. Expanding our understanding of the cellular and molecular mechanisms that dictate pathogenicity in PsA will contribute to developing novel treatment strategies to combat disease. PMID:24424175

  9. The IL-23/IL-17 axis in psoriatic arthritis.

    PubMed

    Suzuki, Erika; Mellins, Elizabeth D; Gershwin, M Eric; Nestle, Frank O; Adamopoulos, Iannis E

    2014-01-01

    Psoriatic arthritis (PsA) is an immune-mediated chronic inflammatory disease, affecting both the skin and joints. Disease progression is associated with aberrant cytokine expression, and TNF blockade is the most successful therapy to date. However, not all patients are responsive to anti-TNF treatment, highlighting the need to better understand the cellular and molecular mechanisms that govern the disease. PsA associations with single nucleotide polymorphisms in IL23R as well as TRAF3IP2 (Act1), a molecule downstream of the IL-17 receptor (IL-17R), have linked the IL-23/IL-17 axis to disease pathology. Although both cytokines are implicated in PsA, a full picture of their cellular targets and pathogenic mechanisms has not yet emerged. In this review, we focus on the IL-23/IL-17 axis-elicited responses mediated by osteoclasts, keratinocytes and neutrophils. Expanding our understanding of the cellular and molecular mechanisms that dictate pathogenicity in PsA will contribute to developing novel treatment strategies to combat disease. Copyright © 2014 Elsevier B.V. All rights reserved.

  10. Moon Park: A research and educational facility

    NASA Technical Reports Server (NTRS)

    Kuriki, Kyoichi; Saito, Takao; Ogawa, Yukimasa

    1992-01-01

    Moon Park has been proposed as an International Space Year (ISY) event for international cooperative efforts. Moon Park will serve as a terrestrial demonstration of a prototype lunar base and provide research and educational opportunities. The kind of data that can be obtained in the Moon Park facilities is examined taking the minimum number of lunar base residents as an example.

  11. Theme Parks: Program Variety and Employment Options.

    ERIC Educational Resources Information Center

    Samuels, Jack B.

    1983-01-01

    This article describes a number of privately operated theme parks, explains why the parks have been successful, and looks at career opportunities for leisure professionals in this expanding area. Implications for recreation education are pointed out, and names and addresses of major companies in the theme park business are provided. (PP)

  12. "The Rosa Parks Story": Guide for Educators.

    ERIC Educational Resources Information Center

    Onish, Liane B.

    On December 1, 1955, Rosa Parks, a black seamstress, refused to give up her seat to a white man on a public bus in Montgomery, Alabama, and she was arrested. On that day, Rosa Parks became the mother of the modern civil rights movement. This study guide may be used as a companion to "The Rosa Parks Story" video which aired on CBS…

  13. 49 CFR 397.7 - Parking.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 5 2011-10-01 2011-10-01 false Parking. 397.7 Section 397.7 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF... PARKING RULES General § 397.7 Parking. (a) A motor vehicle which contains Division 1.1, 1.2, or 1.3...

  14. Parking lot security: protection from liability.

    PubMed

    Hodge, Michael A

    2005-01-01

    Negligent premises security cases, sometimes called "inadequate security", pose great harm to parking facility owners. Verdicts and settlements for negligent security against facilities is a concern, but a greater concern for those property owners engaged in parking lot services. In this article, the author presents some basic principles of security that all owners of parking facilities should not only understand, but embrace.

  15. The Paradox of Parks in Low-Income Areas: Park Use and Perceived Threats.

    PubMed

    Cohen, Deborah A; Han, Bing; Derose, Kathryn P; Williamson, Stephanie; Marsh, Terry; Raaen, Laura; McKenzie, Thomas L

    2016-01-01

    Concerns about safety and perceived threats have been considered responsible for lower use of parks in high poverty neighborhoods. To quantify the role of perceived threats on park use we systematically observed 48 parks and surveyed park users and household residents in low-income neighborhoods in the City of Los Angeles. Across all parks, the majority of both park users and local residents perceive parks as safe or very safe. We noted apparently homeless individuals during nearly half of all observations, but very few instances of fighting, intimidating groups, smoking and intoxication. The presence of homeless individuals was associated with higher numbers of park users, while the presence of intoxicated persons was associated with lower numbers. Overall the strongest predictors of increased park use were the presence of organized and supervised activities. Therefore, to increase park use, focusing resources on programming may be more fruitful than targeting perceived threats.

  16. The Paradox of Parks in Low-Income Areas: Park Use and Perceived Threats

    PubMed Central

    Cohen, Deborah A.; Han, Bing; Derose, Kathryn P.; Williamson, Stephanie; Marsh, Terry; Raaen, Laura; McKenzie, Thomas L.

    2015-01-01

    Concerns about safety and perceived threats have been considered responsible for lower use of parks in high poverty neighborhoods. To quantify the role of perceived threats on park use we systematically observed 48 parks and surveyed park users and household residents in low-income neighborhoods in the City of Los Angeles. Across all parks, the majority of both park users and local residents perceive parks as safe or very safe. We noted apparently homeless individuals during nearly half of all observations, but very few instances of fighting, intimidating groups, smoking and intoxication. The presence of homeless individuals was associated with higher numbers of park users, while the presence of intoxicated persons was associated with lower numbers. Overall the strongest predictors of increased park use were the presence of organized and supervised activities. Therefore, to increase park use, focusing resources on programming may be more fruitful than targeting perceived threats. PMID:27065480

  17. Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family

    PubMed Central

    Li, Hanzhong; Chen, Jian; Huang, Arthur; Stinson, Jeremy; Heldens, Sherry; Foster, Jessica; Dowd, Patrick; Gurney, Austin L.; Wood, William I.

    2000-01-01

    IL-17 is a T cell-derived cytokine that may play an important role in the initiation or maintenance of the proinflammatory response. Whereas expression of IL-17 is restricted to activated T cells, the IL-17 receptor is found to be widely expressed, a finding consistent with the pleiotropic activities of IL-17. We have cloned and expressed two novel human cytokines, IL-17B and IL-17C, that are related to IL-17 (≈27% amino acid identity). IL-17B mRNA is expressed in adult pancreas, small intestine, and stomach, whereas IL-17C mRNA is not detected by RNA blot hybridization of several adult tissues. No expression of IL-17B or IL-17C mRNA is found in activated T cells. In a survey of cytokine induction, IL-17B and IL-17C stimulate the release of tumor necrosis factor α and IL-1β from the monocytic cell line, THP-1, whereas IL-17 has only a weak effect in this system. No induction of IL-1α, IL-6, IFN-γ, or granulocyte colony-stimulating factor is found in THP-1 cells. Fluorescence-activated cell sorter analysis shows that IL-17B and IL-17C bind to THP-1 cells. Conversely, IL-17B and IL-17C are not active in an IL-17 assay or the stimulation of IL-6 release from human fibroblasts and do not bind to the human IL-17 receptor extracellular domain. These data show that there is a family of IL-17-related cytokines differing in patterns of expression and proinflammatory responses that may be transduced through a cognate set of cell surface receptors. PMID:10639155

  18. 36 CFR 7.38 - Isle Royale National Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Isle Royale National Park. 7.38 Section 7.38 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.38 Isle Royale National Park. (a) Aircraft...

  19. 36 CFR 7.18 - Hot Springs National Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Hot Springs National Park. 7.18 Section 7.18 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.18 Hot Springs National Park. (a) Commercial...

  20. 36 CFR 7.66 - North Cascades National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false North Cascades National Park. 7.66 Section 7.66 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.66 North Cascades National Park. (a...

  1. 36 CFR 7.36 - Mammoth Cave National Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Mammoth Cave National Park. 7.36 Section 7.36 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.36 Mammoth Cave National Park. (a) Fishing—(1...

  2. 36 CFR 7.93 - Guadalupe Mountains National Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Guadalupe Mountains National Park. 7.93 Section 7.93 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.93 Guadalupe Mountains National Park...

  3. 36 CFR 7.2 - Crater Lake National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Crater Lake National Park. 7.2 Section 7.2 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.2 Crater Lake National Park. (a) Fishing...

  4. 36 CFR 7.7 - Rocky Mountain National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Rocky Mountain National Park. 7.7 Section 7.7 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.7 Rocky Mountain National Park. (a...

  5. 36 CFR 7.11 - Saguaro National Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Saguaro National Park. 7.11 Section 7.11 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.11 Saguaro National Park. (a) Bicycles. That portion of the...

  6. 36 CFR 7.93 - Guadalupe Mountains National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Guadalupe Mountains National Park. 7.93 Section 7.93 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.93 Guadalupe Mountains National Park...

  7. 36 CFR 7.33 - Voyageurs National Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Voyageurs National Park. 7.33 Section 7.33 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.33 Voyageurs National Park. (a) Fishing. Unless otherwise...

  8. 36 CFR 7.44 - Canyonlands National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Canyonlands National Park. 7.44 Section 7.44 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.44 Canyonlands National Park. (a) Motorized...

  9. 36 CFR 7.5 - Mount Rainier National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Mount Rainier National Park. 7.5 Section 7.5 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.5 Mount Rainier National Park. (a...

  10. 36 CFR 7.23 - Badlands National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Badlands National Park. 7.23 Section 7.23 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.23 Badlands National Park. (a) Commercial vehicles. (1...

  11. 36 CFR 7.2 - Crater Lake National Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Crater Lake National Park. 7.2 Section 7.2 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.2 Crater Lake National Park. (a) Fishing...

  12. 36 CFR 7.16 - Yosemite National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Yosemite National Park. 7.16 Section 7.16 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.16 Yosemite National Park. (a) Fishing—(1) Open season and...

  13. 36 CFR 7.1 - Colonial National Historical Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Colonial National Historical Park. 7.1 Section 7.1 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.1 Colonial National Historical Park. (a...

  14. 36 CFR 7.10 - Zion National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Zion National Park. 7.10 Section 7.10 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.10 Zion National Park. (a) Vehicle convoy requirements. (1...

  15. 36 CFR 7.93 - Guadalupe Mountains National Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Guadalupe Mountains National Park. 7.93 Section 7.93 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.93 Guadalupe Mountains National Park...

  16. 36 CFR 7.33 - Voyageurs National Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Voyageurs National Park. 7.33 Section 7.33 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.33 Voyageurs National Park. (a) Fishing. Unless otherwise...

  17. 36 CFR 7.44 - Canyonlands National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Canyonlands National Park. 7.44 Section 7.44 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.44 Canyonlands National Park. (a) Motorized...

  18. 36 CFR 7.18 - Hot Springs National Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Hot Springs National Park. 7.18 Section 7.18 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.18 Hot Springs National Park. (a) Commercial...

  19. 36 CFR 7.84 - Channel Islands National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Channel Islands National Park. 7.84 Section 7.84 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.84 Channel Islands National Park. (a...

  20. 36 CFR 7.56 - Acadia National Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Acadia National Park. 7.56 Section 7.56 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.56 Acadia National Park. (a) Designated Snowmobile Routes...

  1. 36 CFR 7.7 - Rocky Mountain National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Rocky Mountain National Park. 7.7 Section 7.7 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.7 Rocky Mountain National Park. (a...

  2. 36 CFR 7.84 - Channel Islands National Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Channel Islands National Park. 7.84 Section 7.84 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.84 Channel Islands National Park. (a...

  3. 36 CFR 7.74 - Virgin Islands National Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Virgin Islands National Park. 7.74 Section 7.74 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.74 Virgin Islands National Park. (a) (b...

  4. 36 CFR 7.84 - Channel Islands National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Channel Islands National Park. 7.84 Section 7.84 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.84 Channel Islands National Park. (a...

  5. 36 CFR 7.7 - Rocky Mountain National Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Rocky Mountain National Park. 7.7 Section 7.7 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.7 Rocky Mountain National Park. (a...

  6. 36 CFR 7.7 - Rocky Mountain National Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Rocky Mountain National Park. 7.7 Section 7.7 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.7 Rocky Mountain National Park. (a...

  7. 36 CFR 7.47 - Carlsbad Caverns National Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Carlsbad Caverns National Park. 7.47 Section 7.47 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.47 Carlsbad Caverns National Park. (a...

  8. 36 CFR 7.1 - Colonial National Historical Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Colonial National Historical Park. 7.1 Section 7.1 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.1 Colonial National Historical Park. (a...

  9. 36 CFR 7.10 - Zion National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Zion National Park. 7.10 Section 7.10 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.10 Zion National Park. (a) Vehicle convoy requirements. (1...

  10. 36 CFR 7.47 - Carlsbad Caverns National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Carlsbad Caverns National Park. 7.47 Section 7.47 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.47 Carlsbad Caverns National Park. (a...

  11. 36 CFR 7.1 - Colonial National Historical Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Colonial National Historical Park. 7.1 Section 7.1 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.1 Colonial National Historical Park. (a...

  12. 36 CFR 7.5 - Mount Rainier National Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Mount Rainier National Park. 7.5 Section 7.5 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.5 Mount Rainier National Park. (a...

  13. 36 CFR 7.41 - Big Bend National Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Big Bend National Park. 7.41 Section 7.41 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.41 Big Bend National Park. (a) Fishing; closed waters...

  14. 36 CFR 7.56 - Acadia National Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Acadia National Park. 7.56 Section 7.56 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.56 Acadia National Park. (a) Designated Snowmobile Routes...

  15. 36 CFR 7.10 - Zion National Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Zion National Park. 7.10 Section 7.10 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.10 Zion National Park. (a) Vehicle convoy requirements. (1...

  16. 36 CFR 7.18 - Hot Springs National Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Hot Springs National Park. 7.18 Section 7.18 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.18 Hot Springs National Park. (a) Commercial...

  17. 36 CFR 7.5 - Mount Rainier National Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Mount Rainier National Park. 7.5 Section 7.5 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.5 Mount Rainier National Park. (a...

  18. 36 CFR 7.33 - Voyageurs National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Voyageurs National Park. 7.33 Section 7.33 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.33 Voyageurs National Park. (a) Fishing. Unless otherwise...

  19. 36 CFR 7.11 - Saguaro National Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Saguaro National Park. 7.11 Section 7.11 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.11 Saguaro National Park. (a) Bicycling. (1) The following...

  20. 36 CFR 7.66 - North Cascades National Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false North Cascades National Park. 7.66 Section 7.66 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.66 North Cascades National Park. (a...

  1. 36 CFR 7.36 - Mammoth Cave National Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Mammoth Cave National Park. 7.36 Section 7.36 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.36 Mammoth Cave National Park. (a) Fishing—(1...

  2. 36 CFR 7.11 - Saguaro National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Saguaro National Park. 7.11 Section 7.11 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.11 Saguaro National Park. (a) Bicycling. (1) The following...

  3. 36 CFR 7.15 - Shenandoah National Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Shenandoah National Park. 7.15 Section 7.15 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.15 Shenandoah National Park. (a) Backcountry...

  4. 36 CFR 7.5 - Mount Rainier National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Mount Rainier National Park. 7.5 Section 7.5 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.5 Mount Rainier National Park. (a...

  5. 36 CFR 7.66 - North Cascades National Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false North Cascades National Park. 7.66 Section 7.66 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.66 North Cascades National Park. (a...

  6. 36 CFR 7.54 - Theodore Roosevelt National Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Theodore Roosevelt National Park. 7.54 Section 7.54 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.54 Theodore Roosevelt National Park. (a...

  7. 36 CFR 7.47 - Carlsbad Caverns National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Carlsbad Caverns National Park. 7.47 Section 7.47 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.47 Carlsbad Caverns National Park. (a...

  8. 36 CFR 7.5 - Mount Rainier National Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Mount Rainier National Park. 7.5 Section 7.5 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.5 Mount Rainier National Park. (a...

  9. 36 CFR 7.66 - North Cascades National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false North Cascades National Park. 7.66 Section 7.66 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.66 North Cascades National Park. (a...

  10. 36 CFR 7.54 - Theodore Roosevelt National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Theodore Roosevelt National Park. 7.54 Section 7.54 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.54 Theodore Roosevelt National Park. (a...

  11. 36 CFR 7.41 - Big Bend National Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Big Bend National Park. 7.41 Section 7.41 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.41 Big Bend National Park. (a) Fishing; closed waters...

  12. 36 CFR 7.23 - Badlands National Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Badlands National Park. 7.23 Section 7.23 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.23 Badlands National Park. (a) Commercial vehicles. (1...

  13. 36 CFR 7.16 - Yosemite National Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Yosemite National Park. 7.16 Section 7.16 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.16 Yosemite National Park. (a) Fishing—(1) Open season and...

  14. 36 CFR 7.39 - Mesa Verde National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Mesa Verde National Park. 7.39 Section 7.39 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.39 Mesa Verde National Park. (a) Visiting of...

  15. 36 CFR 7.16 - Yosemite National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Yosemite National Park. 7.16 Section 7.16 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.16 Yosemite National Park. (a) Fishing—(1) Open season and...

  16. 36 CFR 7.41 - Big Bend National Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Big Bend National Park. 7.41 Section 7.41 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.41 Big Bend National Park. (a) Fishing; closed waters...

  17. 36 CFR 7.10 - Zion National Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Zion National Park. 7.10 Section 7.10 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.10 Zion National Park. (a) Vehicle convoy requirements. (1...

  18. 36 CFR 7.2 - Crater Lake National Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Crater Lake National Park. 7.2 Section 7.2 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.2 Crater Lake National Park. (a) Fishing...

  19. 36 CFR 7.41 - Big Bend National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Big Bend National Park. 7.41 Section 7.41 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.41 Big Bend National Park. (a) Fishing; closed waters...

  20. 36 CFR 7.39 - Mesa Verde National Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Mesa Verde National Park. 7.39 Section 7.39 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.39 Mesa Verde National Park. (a) Visiting of...

  1. 36 CFR 7.23 - Badlands National Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Badlands National Park. 7.23 Section 7.23 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.23 Badlands National Park. (a) Commercial vehicles. (1...

  2. 36 CFR 7.54 - Theodore Roosevelt National Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Theodore Roosevelt National Park. 7.54 Section 7.54 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.54 Theodore Roosevelt National Park. (a...

  3. 36 CFR 7.93 - Guadalupe Mountains National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Guadalupe Mountains National Park. 7.93 Section 7.93 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.93 Guadalupe Mountains National Park...

  4. 36 CFR 7.2 - Crater Lake National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Crater Lake National Park. 7.2 Section 7.2 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.2 Crater Lake National Park. (a) Fishing...

  5. 36 CFR 7.15 - Shenandoah National Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Shenandoah National Park. 7.15 Section 7.15 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.15 Shenandoah National Park. (a) Backcountry...

  6. 36 CFR 7.41 - Big Bend National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Big Bend National Park. 7.41 Section 7.41 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.41 Big Bend National Park. (a) Fishing; closed waters...

  7. 36 CFR 7.33 - Voyageurs National Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Voyageurs National Park. 7.33 Section 7.33 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.33 Voyageurs National Park. (a) Fishing. Unless otherwise...

  8. 36 CFR 7.84 - Channel Islands National Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Channel Islands National Park. 7.84 Section 7.84 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.84 Channel Islands National Park. (a...

  9. 36 CFR 7.11 - Saguaro National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Saguaro National Park. 7.11 Section 7.11 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.11 Saguaro National Park. (a) Bicycles. That portion of the...

  10. 36 CFR 7.11 - Saguaro National Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Saguaro National Park. 7.11 Section 7.11 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.11 Saguaro National Park. (a) Bicycles. That portion of the...

  11. 36 CFR 7.56 - Acadia National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Acadia National Park. 7.56 Section 7.56 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.56 Acadia National Park. (a) Designated Snowmobile Routes...

  12. 36 CFR 7.74 - Virgin Islands National Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Virgin Islands National Park. 7.74 Section 7.74 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.74 Virgin Islands National Park. (a) (b...

  13. Visitor perceptions of the benefits of local park

    Treesearch

    Deborah Kerstetter; Andrew Mowen; Nathan Trauntvein; Toni Leichty; Nuno Rubiero

    2009-01-01

    Recent research regarding the perceived benefits of local parks has been limited, posing a problem for recreation and park directors who must promote the value of and gain support for aging park facilities. To collect evidence concerning the value of local parks and the impact of park upgrades, we conducted a study with one local park to (a) document behavioral changes...

  14. 36 CFR 7.15 - Shenandoah National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Shenandoah National Park. 7.15 Section 7.15 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.15 Shenandoah National Park. (a) Backcountry...

  15. 36 CFR 7.39 - Mesa Verde National Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Mesa Verde National Park. 7.39 Section 7.39 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.39 Mesa Verde National Park. (a) Visiting of...

  16. 36 CFR 1253.2 - National Archives at College Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false National Archives at College Park. 1253.2 Section 1253.2 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS... College Park. (a) The National Archives at College Park is located at 8601 Adelphi Road, College Park, MD...

  17. 36 CFR 7.36 - Mammoth Cave National Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Mammoth Cave National Park. 7.36 Section 7.36 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.36 Mammoth Cave National Park. (a) Fishing—(1...

  18. 36 CFR 7.39 - Mesa Verde National Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Mesa Verde National Park. 7.39 Section 7.39 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.39 Mesa Verde National Park. (a) Visiting of...

  19. 36 CFR 7.1 - Colonial National Historical Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Colonial National Historical Park. 7.1 Section 7.1 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.1 Colonial National Historical Park. (a...

  20. 36 CFR 7.18 - Hot Springs National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Hot Springs National Park. 7.18 Section 7.18 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.18 Hot Springs National Park. (a) Commercial...

  1. 36 CFR 7.2 - Crater Lake National Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Crater Lake National Park. 7.2 Section 7.2 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.2 Crater Lake National Park. (a) Fishing...

  2. 36 CFR 7.18 - Hot Springs National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Hot Springs National Park. 7.18 Section 7.18 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.18 Hot Springs National Park. (a) Commercial...

  3. 36 CFR 7.10 - Zion National Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Zion National Park. 7.10 Section 7.10 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.10 Zion National Park. (a) Vehicle convoy requirements. (1...

  4. 36 CFR 7.74 - Virgin Islands National Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Virgin Islands National Park. 7.74 Section 7.74 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.74 Virgin Islands National Park. (a) (b...

  5. 36 CFR 7.84 - Channel Islands National Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Channel Islands National Park. 7.84 Section 7.84 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.84 Channel Islands National Park. (a...

  6. 36 CFR 7.56 - Acadia National Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Acadia National Park. 7.56 Section 7.56 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.56 Acadia National Park. (a) Designated Snowmobile Routes...

  7. 36 CFR 7.54 - Theodore Roosevelt National Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Theodore Roosevelt National Park. 7.54 Section 7.54 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.54 Theodore Roosevelt National Park. (a...

  8. 36 CFR 7.44 - Canyonlands National Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Canyonlands National Park. 7.44 Section 7.44 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.44 Canyonlands National Park. (a) Motorized...

  9. 36 CFR 7.23 - Badlands National Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Badlands National Park. 7.23 Section 7.23 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.23 Badlands National Park. (a) Commercial vehicles. (1...

  10. 36 CFR 7.74 - Virgin Islands National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Virgin Islands National Park. 7.74 Section 7.74 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.74 Virgin Islands National Park. (a) (b...

  11. 36 CFR 7.44 - Canyonlands National Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Canyonlands National Park. 7.44 Section 7.44 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.44 Canyonlands National Park. (a) Motorized...

  12. 36 CFR 7.44 - Canyonlands National Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Canyonlands National Park. 7.44 Section 7.44 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.44 Canyonlands National Park. (a) Motorized...

  13. 36 CFR 7.33 - Voyageurs National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Voyageurs National Park. 7.33 Section 7.33 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.33 Voyageurs National Park. (a) Fishing. Unless otherwise...

  14. 36 CFR 7.93 - Guadalupe Mountains National Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Guadalupe Mountains National Park. 7.93 Section 7.93 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.93 Guadalupe Mountains National Park...

  15. 36 CFR 7.54 - Theodore Roosevelt National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Theodore Roosevelt National Park. 7.54 Section 7.54 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.54 Theodore Roosevelt National Park. (a...

  16. 36 CFR 7.47 - Carlsbad Caverns National Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Carlsbad Caverns National Park. 7.47 Section 7.47 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.47 Carlsbad Caverns National Park. (a...

  17. 36 CFR 7.16 - Yosemite National Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Yosemite National Park. 7.16 Section 7.16 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.16 Yosemite National Park. (a) Fishing—(1) Open season and...

  18. 36 CFR 7.74 - Virgin Islands National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Virgin Islands National Park. 7.74 Section 7.74 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.74 Virgin Islands National Park. (a) (b...

  19. 36 CFR 7.66 - North Cascades National Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false North Cascades National Park. 7.66 Section 7.66 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.66 North Cascades National Park. (a...

  20. 36 CFR 7.7 - Rocky Mountain National Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Rocky Mountain National Park. 7.7 Section 7.7 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.7 Rocky Mountain National Park. (a...

  1. 36 CFR 7.4 - Grand Canyon National Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Grand Canyon National Park. 7.4 Section 7.4 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.4 Grand Canyon National Park. (a) Commercial...

  2. 36 CFR 7.23 - Badlands National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Badlands National Park. 7.23 Section 7.23 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.23 Badlands National Park. (a) Commercial vehicles. (1...

  3. 36 CFR 7.39 - Mesa Verde National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Mesa Verde National Park. 7.39 Section 7.39 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.39 Mesa Verde National Park. (a) Visiting of...

  4. 36 CFR 7.38 - Isle Royale National Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Isle Royale National Park. 7.38 Section 7.38 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.38 Isle Royale National Park. (a) Aircraft...

  5. 36 CFR 7.38 - Isle Royale National Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Isle Royale National Park. 7.38 Section 7.38 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.38 Isle Royale National Park. (a) Aircraft...

  6. 36 CFR 7.15 - Shenandoah National Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Shenandoah National Park. 7.15 Section 7.15 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.15 Shenandoah National Park. (a) Backcountry...

  7. 36 CFR 7.38 - Isle Royale National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Isle Royale National Park. 7.38 Section 7.38 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.38 Isle Royale National Park. (a) Aircraft...

  8. 76 FR 72003 - Paterson Great Falls National Historical Park

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-21

    ... National Park Service Paterson Great Falls National Historical Park AGENCY: National Park Service, Interior..., Public Law 111-11 (codified at 16 U.S.C. 410lll), the National Park Service announces that the Secretary... National Historical Park as a unit of the National Park System. FOR FURTHER INFORMATION CONTACT: Gay...

  9. 36 CFR 7.1 - Colonial National Historical Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Colonial National Historical Park. 7.1 Section 7.1 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.1 Colonial National Historical Park. (a...

  10. 36 CFR 7.47 - Carlsbad Caverns National Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Carlsbad Caverns National Park. 7.47 Section 7.47 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.47 Carlsbad Caverns National Park. (a...

  11. 36 CFR 7.36 - Mammoth Cave National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Mammoth Cave National Park. 7.36 Section 7.36 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.36 Mammoth Cave National Park. (a) Fishing—(1...

  12. 36 CFR 7.38 - Isle Royale National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Isle Royale National Park. 7.38 Section 7.38 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.38 Isle Royale National Park. (a) Aircraft...

  13. 36 CFR 7.15 - Shenandoah National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Shenandoah National Park. 7.15 Section 7.15 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.15 Shenandoah National Park. (a) Backcountry...

  14. 36 CFR 7.56 - Acadia National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Acadia National Park. 7.56 Section 7.56 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.56 Acadia National Park. (a) Designated Snowmobile Routes...

  15. 36 CFR 7.25 - Hawaii Volcanoes National Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Hawaii Volcanoes National Park. 7.25 Section 7.25 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.25 Hawaii Volcanoes National Park. (a...

  16. 36 CFR 7.25 - Hawaii Volcanoes National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Hawaii Volcanoes National Park. 7.25 Section 7.25 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.25 Hawaii Volcanoes National Park. (a...

  17. 36 CFR 7.25 - Hawaii Volcanoes National Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Hawaii Volcanoes National Park. 7.25 Section 7.25 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.25 Hawaii Volcanoes National Park. (a...

  18. 36 CFR 7.25 - Hawaii Volcanoes National Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Hawaii Volcanoes National Park. 7.25 Section 7.25 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.25 Hawaii Volcanoes National Park. (a...

  19. 36 CFR 7.25 - Hawaii Volcanoes National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Hawaii Volcanoes National Park. 7.25 Section 7.25 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.25 Hawaii Volcanoes National Park. (a...

  20. 36 CFR 7.4 - Grand Canyon National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Park. The National Park Service reserves the right to limit the number of such permits issued, or the... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Grand Canyon National Park. 7.4 Section 7.4 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE...

  1. 36 CFR 7.28 - Olympic National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Olympic National Park. 7.28 Section 7.28 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.28 Olympic National Park. (a) Fishing—(1)...

  2. 36 CFR 7.4 - Grand Canyon National Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Park. The National Park Service reserves the right to limit the number of such permits issued, or the... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Grand Canyon National Park. 7.4 Section 7.4 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE...

  3. 36 CFR 7.4 - Grand Canyon National Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Park. The National Park Service reserves the right to limit the number of such permits issued, or the... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Grand Canyon National Park. 7.4 Section 7.4 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE...

  4. 36 CFR 7.4 - Grand Canyon National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Park. The National Park Service reserves the right to limit the number of such permits issued, or the... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Grand Canyon National Park. 7.4 Section 7.4 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE...

  5. 36 CFR 7.28 - Olympic National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Olympic National Park. 7.28 Section 7.28 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.28 Olympic National Park. (a) Fishing—(1)...

  6. Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases

    PubMed Central

    Qu, Ning; Xu, Mingli; Mizoguchi, Izuru; Furusawa, Jun-ichi; Kaneko, Kotaro; Watanabe, Kazunori; Mizuguchi, Junichiro; Itoh, Masahiro; Kawakami, Yutaka; Yoshimoto, Takayuki

    2013-01-01

    T-helper 17 (Th17) cells are characterized by producing interleukin-17 (IL-17, also called IL-17A), IL-17F, IL-21, and IL-22 and potentially TNF-α and IL-6 upon certain stimulation. IL-23, which promotes Th17 cell development, as well as IL-17 and IL-22 produced by the Th17 cells plays essential roles in various inflammatory diseases, such as experimental autoimmune encephalomyelitis, rheumatoid arthritis, colitis, and Concanavalin A-induced hepatitis. In this review, we summarize the characteristics of the functional role of Th17 cells, with particular focus on the Th17 cell-related cytokines such as IL-17, IL-22, and IL-23, in mouse models and human inflammatory diseases. PMID:23956763

  7. IL-4 and IL-13 Inhibition in Atopic Dermatitis.

    PubMed

    Matsunaga, Matthew C; Yamauchi, Paul S

    2016-08-01

    Atopic dermatitis (AD) is a chronic, prevalent, multi-factorial condition that affects infants, children, and adults. Beyond topical therapy, a variety of systemic agents such as steroids, methotrexate, cyclosporine, azathioprine, mycophenoloic acid, and other agents are utilized to treat moderate to severe AD. However, these agents are associated with potential long term adverse events and organ toxicity. There is an unmet need for a safer, long-term systemic agent to adequately control moderate to severe AD. The role of the Th2 cytokines, IL-4 and IL-13, in AD has led to the development of biologic agents to treat AD. The aim of this article is to review the role of IL-4 and IL-13 in the pathogenesis of AD and discuss some of the clinical trial data that target and inhibit IL-4 and IL-13 in positively altering the course and outcome of AD.

    J Drugs Dermatol. 2016;15(8):925-929.

  8. The Geologic Story of Canyonlands National Park

    USGS Publications Warehouse

    Lohman, Stanley William

    1974-01-01

    On September 12, 1964, President Lyndon B. Johnson signed an act of Congress establishing Canyonlands as our thirty second national park, the first addition to the park system since 1956. The birth of Canyonlands National Park was not without labor pains. In the 1930's virtually all the vast canyon country between Moab, Utah, and Grand Canyon, Ariz., was studied for a projected Escalante National Park. But Escalante failed to get off the ground, even when a second attempt was made in the 1950's. Not until another proposal had been made and legislative compromises had been worked out did the park materialize, this time under a new name - Canyonlands. Among the many dignitaries who witnessed the signature on September 12 was one of the men most responsible for the park's creation, park superintendent Bates E. Wilson, who did the pioneer spade work in the field.

  9. Wild pig populations in the National Parks

    NASA Astrophysics Data System (ADS)

    Singer, Francis J.

    1981-05-01

    Populations of introduced European wild boar, feral pigs, and combinations of both types (all Sus scrola L.) inhabit thirteen areas in the National Park Service system. All parks have relatively stable populations, with the exception of Great Smoky Mountains National Park, which reported a rapidly expanding wild boar population. Suspected and documented impacts were apparently related to pig densities and sensitivity of the ecosystem; the three largest units with dense wild pig populations reported the most damage. Overall, wild pigs are a relatively minor problem for the Park Service; however, problems are severe in at least three parks, and there is potential for invasion of wild boars into several additional parks in the Appalachian Mountains. More specific information is needed on numbers of wild pigs and their impacts in the various parks.

  10. Analytical characteristics and comparative evaluation of Aptima HCV quant Dx assay with the Abbott RealTime HCV assay and Roche COBAS AmpliPrep/COBAS TaqMan HCV quantitative test v2.0.

    PubMed

    Worlock, A; Blair, D; Hunsicker, M; Le-Nguyen, T; Motta, C; Nguyen, C; Papachristou, E; Pham, J; Williams, A; Vi, M; Vinluan, B; Hatzakis, A

    2017-04-04

    The Aptima HCV Quant Dx assay (Aptima assay) is a fully automated quantitative assay on the Panther® system. This assay is intended for confirmation of diagnosis and monitoring of HCV RNA in plasma and serum specimens. The purpose of the testing described in this paper was to evaluate the performance of the Aptima assay. The analytical sensitivity, analytical specificity, precision, and linearity of the Aptima assay were assessed. The performance of the Aptima assay was compared to two commercially available HCV assays; the Abbott RealTime HCV assay (Abbott assay, Abbott Labs Illinois, USA) and the Roche COBAS Ampliprep/COBAS Taqman HCV Quantitative Test v2.0 (Roche Assay, Roche Molecular Systems, Pleasanton CA, USA). The 95% Lower Limit of Detection (LoD) of the assay was determined from dilutions of the 2nd HCV WHO International Standard (NIBSC 96/798 genotype 1) and HCV positive clinical specimens in HCV negative human plasma and serum. Probit analysis was performed to generate the 95% predicted detection limits. The Lower Limit of Quantitation (LLoQ) was established for each genotype by diluting clinical specimens and the 2nd HCV WHO International Standard (NIBSC 96/798 genotype 1) in HCV negative human plasma and serum. Specificity was determined using 200 fresh and 536 frozen HCV RNA negative clinical specimens including 370 plasma specimens and 366 serum specimens. Linearity for genotypes 1 to 6 was established by diluting armored RNA or HCV positive clinical specimens in HCV negative serum or plasma from 8.08 log IU/mL to below 1 log IU/mL. Precision was tested using a 10 member panel made by diluting HCV positive clinical specimens or spiking armored RNA into HCV negative plasma and serum. A method comparison was conducted against the Abbott assay using 1058 clinical specimens and against the Roche assay using 608 clinical specimens from HCV infected patients. In addition, agreement between the Roche assay and the Aptima assay using specimens with low

  11. Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2.

    PubMed

    Wang, Mai; Tan, Zhongjia; Zhang, Rong; Kotenko, Sergei V; Liang, Peng

    2002-03-01

    Interleukin 24 (IL-24) encodes a secreted protein that exhibits significant homology to the interleukin 10 (IL-10) family of cytokines. Here we show that the human IL-24 is secreted by activated peripheral blood mononuclear cells and is the ligand for two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2. The latter is also the receptor for IL-20. COS cells transfected with either IL-24 receptor heterodimers bind the ligand with similar saturation kinetics. IL-24 binding to either its endogenous receptors on human keratinocytes or to ectopically expressed receptors on baby hamster kidney cells leads to activation of the signal transducers and activators of transcription. Taken together, these results provide compelling evidence for IL-24 being the fourth member of IL-10 family of cytokines to which their specific receptors have been identified.

  12. Effects of IL-1β, IL-6 and IL-8 on erythrocytes, platelets and clot viscoelasticity

    PubMed Central

    Bester, Janette; Pretorius, Etheresia

    2016-01-01

    Complex interactions exist between cytokines, and the interleukin family plays a fundamental role in inflammation. Particularly circulating IL-1β, IL-6 and IL-8 are unregulated in systemic and chronic inflammatory conditions. Hypercoagulability is an important hallmark of inflammation, and these cytokines are critically involved in abnormal clot formation, erythrocyte pathology and platelet hyper-activation, and these three cytokines have known receptors on platelets. Although these cytokines are always unregulated in inflammation, we do not know how the individual cytokines act upon the structure of erythrocytes and platelets, and which of the viscoelastic clot parameters are changed. Here we study the effects of IL-1β, IL-6 and IL-8 at low physiological levels, representative of chronic inflammation, by using scanning electron microscopy and thromboelastography. All three interleukins caused the viscoelastic properties to display an increased hypercoagulability of whole blood and pathology of both erythrocytes and platelets. The most pronounced changes were noted where all three cytokines caused platelet hyper-activation and spreading. Erythrocyte structure was notably affected in the presence of IL-8, where the morphological changes resembled that typically seen in eryptosis (programmed cell death). We suggest that erythrocytes and platelets are particularly sensitive to cytokine presence, and that they are excellent health indicators. PMID:27561337

  13. Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production.

    PubMed

    Lemos, Henrique P; Grespan, Renata; Vieira, Silvio M; Cunha, Thiago M; Verri, Waldiceu A; Fernandes, Karla S S; Souto, Fabricio O; McInnes, Iain B; Ferreira, Sergio H; Liew, Foo Y; Cunha, Fernando Q

    2009-04-07

    IL-23/IL-17-induced neutrophil recruitment plays a pivotal role in rheumatoid arthritis (RA). However, the mechanism of the neutrophil recruitment is obscure. Here we report that prostaglandin enhances the IL-23/IL-17-induced neutrophil migration in a murine model of RA by inhibiting IL-12 and IFN gamma production. Methylated BSA (mBSA) and IL-23-induced neutrophil migration was inhibited by anti-IL-23 and anti-IL-17 antibodies, COX inhibitors, IL-12, or IFNgamma but was enhanced by prostaglandin E(2) (PGE(2)). IL-23-induced IL-17 production was increased by PGE(2) and suppressed by COX-inhibition or IL-12. Furthermore, COX inhibition failed to reduce IL-23-induced neutrophil migration in IL-12- or IFNgamma-deficient mice. IL-17-induced neutrophil migration was not affected by COX inhibitors, IL-12, or IFNgamma but was inhibited by MK886 (a leukotriene synthesis inhibitor), anti-TNFalpha, anti-CXCL1, and anti-CXCL5 antibodies and by repertaxin (a CXCR1/2 antagonist). These treatments all inhibited mBSA- or IL-23-induced neutrophil migration. IL-17 induced neutrophil chemotaxis through a CXC chemokines-dependent pathway. Our results suggest that prostaglandin plays an important role in IL-23-induced neutrophil migration in arthritis by enhancing IL-17 synthesis and by inhibiting IL-12 and IFNgamma production. We thus provide a mechanism for the pathogenic role of the IL-23/IL-17 axis in RA and also suggest an additional mechanism of action for nonsteroidal anti-inflammatory drugs.

  14. Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNγ production

    PubMed Central

    Lemos, Henrique P.; Grespan, Renata; Vieira, Silvio M.; Cunha, Thiago M.; Verri, Waldiceu A.; Fernandes, Karla S. S.; Souto, Fabricio O.; McInnes, Iain B.; Ferreira, Sergio H.; Liew, Foo Y.; Cunha, Fernando Q.

    2009-01-01

    IL-23/IL-17-induced neutrophil recruitment plays a pivotal role in rheumatoid arthritis (RA). However, the mechanism of the neutrophil recruitment is obscure. Here we report that prostaglandin enhances the IL-23/IL-17-induced neutrophil migration in a murine model of RA by inhibiting IL-12 and IFN γ production. Methylated BSA (mBSA) and IL-23-induced neutrophil migration was inhibited by anti-IL-23 and anti-IL-17 antibodies, COX inhibitors, IL-12, or IFNγ but was enhanced by prostaglandin E2 (PGE2). IL-23-induced IL-17 production was increased by PGE2 and suppressed by COX-inhibition or IL-12. Furthermore, COX inhibition failed to reduce IL-23-induced neutrophil migration in IL-12- or IFNγ-deficient mice. IL-17-induced neutrophil migration was not affected by COX inhibitors, IL-12, or IFNγ but was inhibited by MK886 (a leukotriene synthesis inhibitor), anti-TNFα, anti-CXCL1, and anti-CXCL5 antibodies and by repertaxin (a CXCR1/2 antagonist). These treatments all inhibited mBSA- or IL-23-induced neutrophil migration. IL-17 induced neutrophil chemotaxis through a CXC chemokines-dependent pathway. Our results suggest that prostaglandin plays an important role in IL-23-induced neutrophil migration in arthritis by enhancing IL-17 synthesis and by inhibiting IL-12 and IFNγ production. We thus provide a mechanism for the pathogenic role of the IL-23/IL-17 axis in RA and also suggest an additional mechanism of action for nonsteroidal anti-inflammatory drugs. PMID:19289819

  15. Increased expression of interleukin (IL)-35 and IL-17, but not IL-27, in gingival tissues with chronic periodontitis.

    PubMed

    Mitani, Akio; Niedbala, Wanda; Fujimura, Takeki; Mogi, Makio; Miyamae, Shin; Higuchi, Naoya; Abe, Atsushi; Hishikawa, Toshimitsu; Mizutani, Makoto; Ishihara, Yuichi; Nakamura, Hiroshi; Kurita, Kenichi; Ohno, Norikazu; Tanaka, Yoshinobu; Hattori, Masami; Noguchi, Toshihide

    2015-02-01

    Interleukin (IL)-35 plays an important role in immune regulation through the suppression of effector T-cell populations, including T-helper 17 (Th17) cells. Although Th17 cells and IL-17 are involved in the pathogenesis of periodontitis, the level of IL-35 in inflamed periodontal tissues is unclear. Here, IL-35, IL-17, and IL-27 production/expression in gingival crevicular fluid (GCF) and human gingival tissue were investigated. GCF samples were collected from buccal (mesial, center, and distal) sites of teeth from patients with chronic periodontitis (CP) and healthy controls and were analyzed by enzyme-linked immunosorbent assay for IL-35 (periodontitis, n = 36; healthy, n = 30) and IL-17 (periodontitis, n = 16; healthy, n = 13). Gingival tissue, including sulcus/pocket epithelium and underlying connective tissue, was collected from an additional 10 healthy participants and 10 patients with CP and were analyzed by quantitative polymerase chain reaction (qPCR) for Epstein Barr virus-induced gene 3 (EBI3), IL12A, and IL17A. IL27p28 was also tested by qPCR. IL-35 and IL-17 were significantly higher in GCF from patients with periodontitis than healthy participants (P <0.01, P <0.05, respectively). In both healthy participants and those with periodontitis, positive correlations were found among IL-35 and probing depth and clinical attachment level (CAL) as well as between IL-17 and CAL. EBI3, IL12A (components of IL-35), and IL17A messenger RNA expression levels were significantly higher in inflamed gingival tissue than in healthy control tissues (P <0.05). IL27p28 was not detected in any sample, suggesting that IL-27 is not produced in large quantities in periodontal tissue. IL-35 and IL-17, but not IL-27, may play important roles in the pathogenesis of periodontitis.

  16. Evolution of the IL17 receptor family in chordates: a new subfamily IL17REL.

    PubMed

    Wu, Baojun; Jin, Meng; Zhang, Yi; Wei, Tiandi; Bai, Zengliang

    2011-12-01

    The human interleukin 17 receptor (IL17R) family plays a critical role in inflammatory responses and contributes to the pathology of many autoimmune diseases. So far, five members, IL17RA to IL17RE, have been identified. Recently, some IL17R genes have been identified in non-mammalian species, such as zebrafish IL17RD; however, there are no reports on the evolutionary history of this complex gene family through comparative phylogenetic approaches. Here, we concentrated on the IL17R evolution in chordates. There are two IL17Rs in the genome of the basal chordate amphioxus: IL17RA and IL17RD. After two rounds of whole genome duplications, these two IL17R genes expanded into five early vertebrate IL17R genes, IL17RA to IL17RE. IL17RA and IL17RD are found in most vertebrates, whereas the other three, IL17RB, ILR17RC, and IL17RE, underwent some loss in vertebrates during evolution. Our sequence and structure analyses reveal functional similarities and distinctions between the different IL17Rs. Based on similarity searches for IL17R-like proteins within chordate sequences, a group of IL17RE-like (IL17REL) proteins were identified from mammalians to lower vertebrates. In silico and expression analyses on the novel IL17RELs showed that this group of receptors is highly conserved across species, indicating that IL17REL may represent a unique subfamily of IL17Rs.

  17. Parks and golf course workers.

    PubMed

    Duvall, K

    2001-01-01

    Most of the work done by parks and golf course workers is performed outside, and they are subject to risks similar to those of other outdoor workers, such as temperature and weather-related problems, infectious diseases, and poisonous plants, snakes, and spiders. They are also exposed to physical hazards related to noise and operation of heavy equipment. Chemical hazards result from use of pesticides and solvents. This chapter reviews pertinent OSHA regulations, pre-placement strategies, and medical surveillance exams, and recommends preventive programs. More research is needed to determine specific hazards and work-related injury and illness rates for parks and golf course workers, so that effective preventive programs can be designed.

  18. Buddingtonite in Menlo Park, California

    USGS Publications Warehouse

    Pampeyan, Earl H.

    2010-01-01

    The mineral buddingtonite, named after A.F. Buddington, long-time professor of petrology at Princeton University, was first identified at the Sulfur Bank mine in Lake County, California (Erd and others, 1964). The ammonium feldspar was recognized in Menlo Park, California, in 1964 by the author, with Erd's help, shortly before publication of the original description of the new mineral. Subsequently, buddingtonite has been widely recognized in hydrothermal mineral deposits and has been used in remote-sensing applications by the mineral industry. Buddingtonite also has been identified in the Phosphoria Formation and in oil shales of the Green River Formation. This paper briefly describes the geologic setting and mineralogy of the occurrences of buddingtonite and other ammonium-bearing minerals in the vicinity of Menlo Park.

  19. Energetics and Cooling in Urban Parks

    NASA Astrophysics Data System (ADS)

    Spronken-Smith, Rachel Anne

    While there has been a long tradition for the integration of architecture and landscape to improve the urban environment, little is known about the effect of urban parks on local climate. In this study the park effect is determined through an integrated research approach incorporating field measurements of the thermal regime and energetics of urban parks, together with scale modelling of nocturnal cooling in urban parks. The research is limited to consideration of the park effect in two cities with different summer climates: Sacramento, California (hot summer Mediterranean) and Vancoucer, British Columbia (cool summer Mediterranean). In both these cities, surveys of summer-time air temperature patterns associated with urban parks confirm and extend previous findings. In temperate Vancouver, the park effect is typically 1-2^circC, rarely more than 3^circC, although it can be higher under ideal conditions. However, in a hot, dry city, the effect is considerably enhanced with parks as much as 5-7^circC cooler than their urban surrounds. A comparison of the surface energy balance of small open, grassed parks in these two cities demonstrated the importance of evapotranspiration in park energetics. In hot, dry Sacramento, evaporation in the park was advectively -assisted and exceeded that at an irrigated rural site. Strong advective edge effects on evaporation were observed in this wet park. These decayed approximately exponentially with distance into the park. The urban park in Vancouver was moist, but unirrigated. While evaporation dominated the surface energy balance, the sensible heat flux was positive through most of the day, and evaporation was not strongly influenced by advection. The evaporation trend in the park probably reflected the turbulence and soil moisture regimes. However, an irrigated lawn in Vancouver did exhibit edge-type advection. This suggests the soil moisture regime may be critical in determining whether evaporation exceeds the potential rate

  20. Coltsville National Historical Park Act

    THOMAS, 113th Congress

    Sen. Blumenthal, Richard [D-CT

    2013-03-19

    Senate - 04/23/2013 Committee on Energy and Natural Resources Subcommittee on National Parks. Hearings held. With printed Hearing: S.Hrg. 113-27. (All Actions) Notes: For further action, see H.R.3979, which became Public Law 113-291 on 12/19/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  1. STS-130 Nationals Park Visit

    NASA Image and Video Library

    2010-04-20

    The crew of STS-130 present the principal owner of the Washington Nationals, Debra Lerner Cohen (holding montage) with a montage of their mission, Tuesday, April 20, 2010 at Nationals Park in Washington. From left are seen Commander George Zamka, Mission Specialist Nicholas Patrick, Pilot Terry Virts, Debra Lerner Cohen, Edward Cohen, Mission Specialist Kathryn Hire, Mission Specialist Robert Behnken, Lauren Lerner, Jacob Lerner and Alan Gottlieb. Photo Credit: (NASA/Carla Cioffi)

  2. Heritage Park Facilities PV Project

    SciTech Connect

    Hobaica, Mark

    2013-09-26

    Project Objective: To procure a photovoltaic array (PV) system which will generate approximately 256kW of power to be used for the operations of the Aquatic Complex and the adjacent Senior Facility at the Heritage Park. This project complies with the EERE’s work and objectives by promoting the development and deployment of an energy system that will provide current and future generations with clean, efficient, affordable, and reliable energy.

  3. Association study of functional polymorphisms in interleukins and interleukin receptors genes: IL1A, IL1B, IL1RN, IL6, IL6R, IL10, IL10RA and TGFB1 in schizophrenia in Polish population.

    PubMed

    Kapelski, Pawel; Skibinska, Maria; Maciukiewicz, Malgorzata; Wilkosc, Monika; Frydecka, Dorota; Groszewska, Agata; Narozna, Beata; Dmitrzak-Weglarz, Monika; Czerski, Piotr; Pawlak, Joanna; Rajewska-Rager, Aleksandra; Leszczynska-Rodziewicz, Anna; Slopien, Agnieszka; Zaremba, Dorota; Twarowska-Hauser, Joanna

    2015-12-01

    Schizophrenia has been associated with a large range of autoimmune diseases, with a history of any autoimmune disease being associated with a 45% increase in risk for the illness. The inflammatory system may trigger or modulate the course of schizophrenia through complex mechanisms influencing neurodevelopment, neuroplasticity and neurotransmission. In particular, increases or imbalance in cytokine before birth or during the early stages of life may affect neurodevelopment and produce vulnerability to the disease. A total of 27 polymorphisms of IL1N gene: rs1800587, rs17561; IL1B gene: rs1143634, rs1143643, rs16944, rs4848306, rs1143623, rs1143633, rs1143627; IL1RN gene: rs419598, rs315952, rs9005, rs4251961; IL6 gene: rs1800795, rs1800797; IL6R gene: rs4537545, rs4845617, rs2228145, IL10 gene: rs1800896, rs1800871, rs1800872, rs1800890, rs6676671; IL10RA gene: rs2229113, rs3135932; TGF1B gene: rs1800469, rs1800470; each selected on the basis of molecular evidence for functionality, were investigated in this study. Analysis was performed on a group of 621 patients with diagnosis of schizophrenia and 531 healthy controls in Polish population. An association of rs4848306 in IL1B gene, rs4251961 in IL1RN gene, rs2228145 and rs4537545 in IL6R with schizophrenia have been observed. rs6676671 in IL10 was associated with early age of onset. Strong linkage disequilibrium was observed between analyzed polymorphisms in each gene, except of IL10RA. We observed that haplotypes composed of rs4537545 and rs2228145 in IL6R gene were associated with schizophrenia. Analyses with family history of schizophrenia, other psychiatric disorders and alcohol abuse/dependence did not show any positive findings. Further studies on larger groups along with correlation with circulating protein levels are needed.

  4. [Analytical study of the Abbott and Ortho tests for screening and confirmation of anti-HCV antibodies. Le groupe de Travail "Hépatites virales" de la Société Française de Transfusion Sanguine].

    PubMed

    Janot, C; Couroucé, A M; Boudart, D; Cotte, C; Elghouzzi, M H; Jullien, A M; Lemaire, J M; Maisonneuve, P; Maniez-Montreuil, M; Mattlinger, B

    1992-07-01

    Anti-HCV systematic screening on blood donation was mandatory in France since first of March 1991. Two laboratories (Ortho-Chiron and Abbott) have introduced in Europe successively two kinds of hepatitis C positive diagnosis with 1st and 2nd generation ELISA screening and confirmatory assays. The aim of this multicentric study was to evaluated the sensibility and specificity of these tests. For that, they used 10,090 blood sera. As a result we have seen that the new "second generation" screening assays have a higher sensitivity without less of specificity for the confirmatory tests.

  5. IL-17A, IL-22, IL-6, and IL-21 Serum Levels in Plaque-Type Psoriasis in Brazilian Patients

    PubMed Central

    de Oliveira, Priscilla Stela Santana; Cardoso, Pablo Ramon Gualberto; Lima, Emerson Vasconcelos de Andrade; Pereira, Michelly Cristiny; Duarte, Angela Luzia Branco Pinto; Pitta, Ivan da Rocha; Rêgo, Moacyr Jesus Barreto de Melo; Pitta, Maira Galdino da Rocha

    2015-01-01

    Psoriasis is a chronic inflammatory skin disease characterized by alterations in cytokines produced by both Th1 and Th17 pathways. The aim of this study was to evaluate serum levels of pivotal cytokines and correlate them with clinical parameters. Serum samples from 53 psoriasis patients and 35 healthy volunteers, matched by the proportion of sex and age ratios, were collected for ELISA cytokine detection. Psoriasis Area and Severity Index (PASI) was assessed at the time of sampling in psoriasis patients. Our findings demonstrate that IL-17A, IL-22, and IL-6 serum concentrations were significantly higher in psoriasis patients than in the control group. No statistical correlation could be found between cytokines concentrations, PASI score, and age in this study. Although our results do not show any correlation between serum levels of IL-17A, IL-22, and IL-6 and disease activity, the present study confirms that they were increased in Brazilian psoriasis patients in comparison to healthy volunteers. PMID:26351408

  6. IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex.

    PubMed

    Chackerian, Alissa A; Oldham, Elizabeth R; Murphy, Erin E; Schmitz, Jochen; Pflanz, Stefan; Kastelein, Robert A

    2007-08-15

    IL-33 (IL-1F11) is a recently described member of the IL-1 family of cytokines that stimulates the generation of cells, cytokines, and Igs characteristic of a type 2 immune response. IL-33 mediates signal transduction through ST2, a receptor expressed on Th2 and mast cells. In this study, we demonstrate that IL-33 and ST2 form a complex with IL-1R accessory protein (IL-1RAcP), a signaling receptor subunit that is also a member of the IL-1R complex. Additionally, IL-1RAcP is required for IL-33-induced in vivo effects, and IL-33-mediated signal transduction can be inhibited by dominant-negative IL-1RAcP. The implications of this shared usage of IL-1RAcP by IL-1(alpha and beta) and IL-33 are discussed.

  7. The potential for pocket parks to increase physical activity.

    PubMed

    Cohen, Deborah A; Marsh, Terry; Williamson, Stephanie; Han, Bing; Derose, Kathryn Pitkin; Golinelli, Daniella; McKenzie, Thomas L

    2014-01-01

    To assess the use of new pocket parks in low-income neighborhoods. The design of the study was a quasi-experimental post-test only comparison. Los Angeles, California, was the setting for the study. Subjects were park users and residents living within .5 mile of three pocket parks and 15 neighborhood parks. The creation of pocket parks. We used the System of Observing Play and Recreation in Communities (SOPARC) tool to measure park use and park-based physical activity, and then surveyed park users and residents about their park use. We surveyed 392 and 432 household members within .5 mile of the three pocket parks before and after park construction, respectively, as well as 71 pocket park users, and compared them to 992 neighborhood park users and 342 residents living within .5 mile of other neighborhood parks. We compared pocket park use to playground area use in the larger neighborhood parks. We used descriptive statistics and generalized estimating equations for the analysis. Overall, pocket park use compared favorably in promoting moderate-to-vigorous physical activity with that of existing playground space in nearby parks, and they were cost-effective at $0.73/MET hour (metabolic equivalent hour) gained. Pocket park visitors walked an average of .25 miles to get to a park. Pocket parks, when perceived as attractive and safe destinations, may increase physical activity by encouraging families with children to walk there. Additional strategies and programs may be needed to encourage more residents to use these parks.

  8. Comparison of clinical and analytical performance of the Abbott Realtime High Risk HPV test to the performance of hybrid capture 2 in population-based cervical cancer screening.

    PubMed

    Poljak, Mario; Ostrbenk, Anja; Seme, Katja; Ucakar, Veronika; Hillemanns, Peter; Bokal, Eda Vrtacnik; Jancar, Nina; Klavs, Irena

    2011-05-01

    The clinical performance of the Abbott RealTime High Risk HPV (human papillomavirus) test (RealTime) and that of the Hybrid Capture 2 HPV DNA test (hc2) were prospectively compared in the population-based cervical cancer screening setting. In women >30 years old (n = 3,129), the clinical sensitivity of RealTime for detection of cervical intraepithelial neoplasia of grade 2 (CIN2) or worse (38 cases) and its clinical specificity for lesions of less than CIN2 (3,091 controls) were 100% and 93.3%, respectively, and those of hc2 were 97.4% and 91.8%, respectively. A noninferiority score test showed that the clinical specificity (P < 0.0001) and clinical sensitivity (P = 0.011) of RealTime were noninferior to those of hc2 at the recommended thresholds of 98% and 90%. In the total study population (women 20 to 64 years old; n = 4,432; 57 cases, 4,375 controls), the clinical sensitivity and specificity of RealTime were 98.2% and 89.5%, and those of hc2 were 94.7% and 87.7%, respectively. The analytical sensitivity and analytical specificity of RealTime in detecting targeted HPV types evaluated with the largest sample collection to date (4,479 samples) were 94.8% and 99.8%, and those of hc2 were 93.4% and 97.8%, respectively. Excellent analytical agreement between the two assays was obtained (kappa value, 0.84), while the analytical accuracy of RealTime was significantly higher than that of hc2. RealTime demonstrated high intralaboratory reproducibility and interlaboratory agreement with 500 samples retested 61 to 226 days after initial testing in two different laboratories. RealTime can be considered to be a reliable and robust HPV assay clinically comparable to hc2 for the detection of CIN2+ lesions in a population-based cervical cancer screening setting.

  9. Measures of Viral Load using Abbott Real-Time HIV-1 Assay on Venous and Fingerstick Dried Blood Spots from Provider-Collected Specimens in Malawian District Hospitals

    PubMed Central

    Rutstein, Sarah E.; Kamwendo, Deborah; Lugali, Lebah; Thengolose, Isaac; Tegha, Gerald; Fiscus, Susan A.; Nelson, Julie A. E.; Hosseinipour, Mina C.; Sarr, Abdoulaye; Gupta, Sundeep; Chimbwandira, Frank; Mwenda, Reuben; Mataya, Ronald

    2014-01-01

    Background Viral suppression is a key indicator of antiretroviral therapy (ART) response among HIV-infected patients. Dried blood spots (DBS) are an appealing alternative to conventional plasma-based virologic testing, improving access to monitoring in resource-limited settings. However, validity of DBS obtained from fingerstick in field settings remains unknown. Objectives Investigate feasibility and accuracy of DBS vs plasma collected by healthcare workers in real-world settings of remote hospitals in Malawi. Compare venous DBS to fingerstick DBS for identifying treatment failure. Study design We recruited patients from ART clinics at two district hospitals in Malawi, collecting plasma, venous DBS (vDBS), and fingerstick DBS (fsDBS) cards for the first 149 patients, and vDBS and fsDBS only for the subsequent 398 patients. Specimens were tested using Abbott RealTime HIV-1 Assay (lower detection limit 40 copies/ml (plasma) and 550 copies/ml (DBS)). Results 21/149 (14.1%) had detectable viremia (>1.6 log copies/ml), 13 of which were detectable for plasma, vDBS, and fsDBS. Linear regression demonstrated high correlation for plasma vs. DBS (vDBS: β=1.19, R2 0.93 (p<0.0001); fsDBS β=1.20, R2 0.90 (p<0.0001)) and vDBS vs. fsDBS (β=0.88, R2 0.73, (p<0.0001)). Mean difference between plasma and vDBS was 0.51 log copies/ml [SD: 0.33] and plasma and fsDBS 0.46 log copies/ml [SD: 0.30]. At 5000 copies/ml, sensitivity was 100%, and specificity was 98.6% and 97.8% for vDBS and fsDBS, respectively, compared to plasma. Conclusions DBS from venipuncture and fingerstick perform well at the failure threshold of 5000 copies/ml. Fingerstick specimen source may improve access to virologic treatment monitoring in resource-limited settings given task-shifting in high-volume, low-resource facilities. PMID:24906641

  10. IL-19 and IL-20: two novel cytokines with importance in inflammatory diseases.

    PubMed

    Sabat, Robert; Wallace, Elizabeth; Endesfelder, Stefanie; Wolk, Kerstin

    2007-05-01

    IL-19 and IL-20 are two cytokines that were discovered in 2000 and 2001, respectively. Based on the structure and location of their genes, their primary and secondary protein structures and the used receptor complexes, they were classified with IL-10, IL-22, IL-24, IL-26, IL-28 and IL-29 in the IL-10 family of cytokines, and form a subgroup with IL-24 within this family. IL-19 and IL-20 are produced by monocytes as well as non-immune tissue cells under inflammatory conditions. IL-19 and IL-20 act via a receptor complex that consists of the IL-20R1 and IL-20R2 chains. IL-20 is additionally able to signal via a second receptor complex (IL-22R1/IL-20R2). It is controversial whether or not IL-19 and IL-20 regulate the function of immune cells. However, the expression of their receptors aliments the perception that the cells of the skin, lungs and reproductive organs as well as various glands are major targets of these mediators. Results from animal experiments and massively increased expression of these mediators in human inflamed tissues support the assumption that they play an important role in the pathogenesis of a few inflammatory diseases. For this reason, the authors have reviewed the facts known at present regarding these cytokines and postulate that IL-19 and IL-20 are pharmacologically interesting distal elements of an inflammatory cascade.

  11. Parking, energy consumption and air pollution.

    PubMed

    Höglund, Paul G

    2004-12-01

    This paper examines the impacts of different ways of parking on environmental effects, mainly vehicle emissions and air pollution. Vehicle energy consumption and the urban air quality at street level, related to location and design of parking establishments, need to be assessed and quantified. In addition, the indoor parking environment needs attention. This paper gives a description of a methodological approach when comparing different parking establishments. The paper also briefly describes a Swedish attempt to create methods and models for assessing and quantifying such problem. The models are the macrolevel model BRAHE, for regional traffic exhaust emission, and the micromodel SimPark, a parking search model attempt combined with emission models. Until now, very limited knowledge exists regarding the various aspects of vehicle parking and environmental effects in the technical field as well as in the social and human behaviour aspects. This requires an interdisciplinary approach to this challenging area for research, development and more directly practically implemented surveys and field studies. In order to illustrate the new evaluation methodology, the paper also contains some results from a pilot study in Stockholm. Given certain assumptions, a study of vehicle emissions from parking in an underground garage compared with kerbside parking has given an emission reduction of about 40% in favour of the parking garage. This study has been done using the models mentioned above.

  12. Torres del Paine National Park

    NASA Image and Video Library

    2017-09-27

    Grinding glaciers and granite peaks mingle in Chile’s Torres del Paine National Park. The Advanced Land Imager (ALI) on NASA’s Earth Observing-1 (EO-1) satellite captured this summertime image of the park on January 21, 2013. This image shows just a portion of the park, including Grey Glacier and the mountain range of Cordillera del Paine. The rivers of glacial ice in Torres del Paine National Park grind over bedrock, turning some of that rock to dust. Many of the glaciers terminate in freshwater lakes, which are rich with glacial flour that colors them brown to turquoise. Skinny rivers connect some of the lakes to each other (image upper and lower right). Cordillera del Paine rises between some of the wide glacial valleys. The compact mountain range is a combination of soaring peaks and small glaciers, most notably the Torres del Paine (Towers of Paine), three closely spaced peaks emblematic of the mountain range and the larger park. By human standards, the mountains of Cordillera del Paine are quite old. But compared to the Rocky Mountains (70 million years old), and the Appalachians (about 480 million years), the Cordillera del Paine are very young—only about 12 million years old. A study published in 2008 described how scientists used zircon crystals to estimate the age of Cordillera del Paine. The authors concluded that the mountain range was built in three pulses, creating a granite laccolith, or dome-shaped feature, more than 2,000 meters (7,000 feet) thick. NASA Earth Observatory image created by Jesse Allen and Robert Simmon, using Advanced Land Imager data from the NASA EO-1 team. Caption by Michon Scott. Instrument: EO-1 - ALI View more info: earthobservatory.nasa.gov/IOTD/view.php?id=80266 Credit: NASA Earth Observatory NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA

  13. Family structure and park use among parents.

    PubMed

    Fan, Yingling; French, Simone A; Das, Kirti V

    2012-11-01

    Despite the increasingly diversified family structure in the U.S., little research examines differences in park use between nontraditional and traditional family structures. This study examines family-structure differences in parent park use. It was hypothesized that working single parents and dual-worker parents have lower levels of park use than parents in two-parent, single-worker families. Data from a 2010 park-use survey in three urban neighborhoods in Minneapolis MN (N=261 parents) were analyzed in 2012. Multiple variables of park use were developed, including recalled measures over the past 3 days and over the past year. Family-structure differences in these variables were examined using multivariate regression analyses. After controlling for spatial clustering effects and confounding factors, working single parents reported 32.6% (p<0.10) fewer park visits and 62.0% (p<0.05) less time spent in parks in the past 3 days than parents in two-parent, single-worker families. Dual-worker parents did not report fewer park visits in the past 3 days than parents in two-parent, single-worker families, yet the length of time they spent in parks during these visits was 41.5% (p<0.10) less. Family-structure differences in past-year park-use measures were not significant. This research shows the importance of including family-structure variables and both recent and longer-term recalled measures of park use in park-use studies. Greater attention to the recreation needs of working single parents and dual-worker parents is needed in descriptive and intervention research aiming to promote park use among families with children. Copyright © 2012 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

  14. Quantitative Contribution of IL2Rγ to the Dynamic Formation of IL2-IL2R Complexes

    PubMed Central

    Ponce, Luis F.; García-Martínez, Karina; León, Kalet

    2016-01-01

    Interleukin-2 (IL2) is a growth factor for several immune cells and its function depends on its binding to IL2Rs in the cell membrane. The most accepted model for the assembling of IL2-IL2R complexes in the cell membrane is the Affinity Conversion Model (ACM). This model postulates that IL2R receptor association is sequential and dependent on ligand binding. Most likely free IL2 binds first to IL2Rα, and then this complex binds to IL2Rβ, and finally to IL2Rγ (γc). However, in previous mathematical models representing this process, the binding of γc has not been taken into account. In this work, the quantitative contribution of the number of IL2Rγ chain to the IL2-IL2R apparent binding affinity and signaling is studied. A mathematical model of the affinity conversion process including the γ chain in the dynamic, has been formulated. The model was calibrated by fitting it to experimental data, specifically, Scatchard plots obtained using human cell lines. This paper demonstrates how the model correctly explains available experimental observations. It was estimated, for the first time, the value of the kinetic coefficients of IL2-IL2R complexes interaction in the cell membrane. Moreover, the number of IL2R components in different cell lines was also estimated. It was obtained a variable distribution in the number of IL2R components depending on the cell type and the activation state. Of most significance, the study predicts that not only the number of IL2Rα and IL2Rβ, but also the number of γc determine the capacity of the cell to capture and retain IL2 in signalling complexes. Moreover, it is also showed that different cells might use different pathways to bind IL2 as consequence of its IL2R components distribution in the membrane. PMID:27195783

  15. Elevated IL-37, IL-18 and IL-18BP serum concentrations in patients with primary Sjögren's syndrome.

    PubMed

    Liuqing, Wang; Liping, Xia; Hui, Shen; Jing, Lu

    2017-03-01

    The objectives of this study were to examine the serum levels of interleukin (IL)-37 and its clinical association in patients with primary Sjögren's syndrome (pSS) and to investigate whether or not IL-37 participates in the regulation of the pathogenesis of pSS. ELISA was used to analyse the serum levels of IL-37, total IL-18 and IL-18 binding protein (IL-18BP). The level of free IL-18 was calculated based on the mass action law. The correlations between the IL-37 serum levels with the laboratory values and the total IL-18 and IL-18BP serum levels were analyzed by a Spearman's correlation test. The serum levels of IL-37 in the patients with pSS were significantly increased compared with the healthy controls (HCs). The levels were especially elevated in the patients with pSS with positive anti-Ro/SSA and/or anti-La/SSB antibodies. Furthermore, the patients with pSS showed high serum levels of total IL-18, free IL-18 and IL-18BP compared with the HCs. Strikingly, the IL-37 levels were significantly positively correlated with the antibody levels in the patients with pSS, including rheumatoid factor, anti-Ro/SSA, and anti-La/SSB and the total IL-18 and IL-18BP serum levels. The serum levels of IL-37, which were correlated with antibody production and the serum levels of total IL-18 and IL-18BP, were elevated in the patients with pSS. IL-37, an important anti-inflammatory cytokine, may participate in the regulation of the pathogenesis of pSS. Copyright © 2017 American Federation for Medical Research.

  16. The Potential for Pocket Parks to Increase Physical Activity

    PubMed Central

    Cohen, Deborah A.; Marsh, Terry; Williamson, Stephanie; Han, Bing; Derose, Kathryn Pitkin; Golinelli, Daniella; McKenzie, Thomas L.

    2014-01-01

    Purpose To assess the use of new pocket parks in low-income neighborhoods. Setting Los Angeles Subjects Parks users and residents living within ½ mile of 3 pocket parks and 15 neighborhood parks Intervention The creation of pocket parks Design Quasi-experimental post-only comparison Measures We used the System of Observing Play and Recreation in Communities (SOPARC) to measure park use and park-based physical activity and surveyed park users and residents about their park use. Analysis We surveyed 392 and 432 household members within one-half mile of the 3 pocket parks before and after park construction, respectively, as well as 71 pocket park users and compared them to 992 neighborhood park users and 342 residents living within ½ mile of other neighborhood parks. We compared pocket park use to playground area use in the larger neighborhood parks. We used descriptive statistics and Generalized Estimating Equations for the analysis. Results Overall, pocket park use compared favorably in promoting moderate-to-vigorous physical activity with that of existing playground space in nearby parks and they were cost-effective at $0.73/MET hour gained. Pocket park visitors walked an average of 0.25 miles to get there. Conclusions Pocket parks, when perceived as attractive and safe destinations, may increase physical activity by encouraging families with children to walk there. Additional strategies and programs may be needed to encourage more residents to use the parks. PMID:24380461

  17. IL-28 and IL-29: newcomers to the interferon family.

    PubMed

    Uzé, Gilles; Monneron, Danièle

    2007-01-01

    IL-28 and IL-29 were recently described as members of a new cytokine family that shares with type I interferon (IFN) the same Jak/Stat signalling pathway driving expression of a common set of genes. Accordingly, they have been named IFN lambda. IFNs lambda exhibit several common features with type I IFNs: antiviral activity, antiproliferative activity and in vivo antitumour activity. Importantly, however, IFNs lambda bind to a distinct membrane receptor, composed of IFNLR1 and IL10R2. This specific receptor usage suggests that this cytokine family does not merely replicate the type I IFN system and justifies its designation as type III IFN by the nomenclature committee of the International Society of Interferon and Cytokine Research.

  18. Serum TNF-α, sTNFR1, IL-6, IL-8 and IL-10 levels in Weil's syndrome.

    PubMed

    Kyriakidis, Ioannis; Samara, Pinelopi; Papa, Anna

    2011-05-01

    Studies on cytokine levels in Weil's syndrome are lacking. In this study, TNF-α, sTNFR1, IL-6, IL-8 and IL-10 levels were measured in 44 serum samples of patients diagnosed with Leptospira interrogans serovar icterohaemorrhagiae infection. TNF-α levels linked with pulmonary hemorrhagic implications, while elevated sTNFR1 and IL-10 levels linked with fatal cases. IL-6 and IL-8 did not seem to affect the outcome of the disease. Immune response pattern in Weil's syndrome bears resemblance to other patterns described for hemorrhagic fevers. IL-10/TNF-α ratio is proposed as a marker for prognosis.

  19. Denali Park wolf studies: Implications for Yellowstone

    USGS Publications Warehouse

    Mech, L. David; Meier, Thomas J.; Burch, John W.

    1991-01-01

    The Northern Rocky Mountain Wolf Recovery Plan approved by the U.S. Fish and Wildlife Service (1987) recommends re-establishment of wolves (Canis lupus) in Yellowstone National Park. Bills proposing wolf re-establishment in the Park have been introduced into the U.S. House and Senate. However, several questions have been raised about the possible effects of wolf re-establishment on other Yellowstone Park fauna, on human use of the Park and on human use of surrounding areas. Thus the proposed wolf re-establishment remains controversial.Information pertinent to some of the above questions is available from a current study of wolf ecology in Denali National Park and Preserve, Alaska, which we began in 1986. Although Denali Park differs from Yellowstone in several ways, it is also similar enough in important respects to provide insight into questions raised about wolf re-establishment in Yellowstone.

  20. Evaluation of the Beckman Coulter UniCel DxH 800, Beckman Coulter LH 780, and Abbott Diagnostics Cell-Dyn Sapphire hematology analyzers on adult specimens in a tertiary care hospital.

    PubMed

    Tan, Brent T; Nava, Armando J; George, Tracy I

    2011-06-01

    We evaluated the new Beckman Coulter DxH 800 hematology analyzer (Beckman Coulter, Miami, FL) vs the Abbott Diagnostics Cell-Dyn Sapphire (Abbott Diagnostics, Santa Clara, CA) and Beckman Coulter LH 780 hematology analyzers using 430 adult specimens. The DxH 800 provided a CBC and differential that correlated well with those of the Sapphire and LH 780, with most parameters showing correlation coefficients (r) of more than 0.97. In the instrument vs 400-cell manual differential comparison, all 3 instruments showed similar and acceptable accuracy to the reference method except for nucleated RBC (NRBC) enumeration, in which the DxH 800 and Sapphire outperformed the LH 780. We also compared clinical efficiency by determining whether flagged specimens showed abnormalities on a peripheral blood smear as defined by International Council for Standardization in Haematology criteria. The efficiency, sensitivity, and specificity of the DxH 800 were 77.0%, 87.1%, and 73.0%, respectively, compared with the Sapphire at 75.8%, 93.5%, and 68.8%, respectively, and LH 780 at 66.1%, 93.5%, and 55.3%, respectively.

  1. Comparison of BioStar Strep A OIA optical immune assay, Abbott TestPack Plus Strep A, and culture with selective media for diagnosis of group A streptococcal pharyngitis.

    PubMed Central

    Roe, M; Kishiyama, C; Davidson, K; Schaefer, L; Todd, J

    1995-01-01

    We directly compared three techniques for the diagnosis of group A streptococcal pharyngitis in 500 symptomatic children seen in the Emergency Department or Child Care Clinic of The Children's Hospital of Denver. Throats were vigorously swabbed with two rayon swabs, which were transported immediately to the Microbiology Laboratory. Each swab was cultured aerobically on Strep A Isolation Agar (Remel) and then tested for antigen-one swab by the Strep A OIA optical immune assay (BioStar) and the other by the TestPack Plus Strep A (Abbott) technique. Each test was performed blind to the others. The refrigerated pledget was cultured in Todd-Hewitt broth if an antigen test was positive and both direct plate cultures were negative (the "gold standard" was any culture positive). All isolates were serologically grouped. Of 500 complete patient cultures, 151 (30%) were positive for group A streptococcal growth. The two antigen tests gave comparable results with an average sensitivity of 83%. Each was significantly (P < 0.02) less sensitive than its corresponding culture. The BioStar Strep A OIA optical immune assay produced significantly (P < 0.003) more false-positive results than did the Abbott test. Rapid antigen testing is not sensitive enough to eliminate the need for backup cultures. PMID:7650184

  2. 2. SOUTH SIDE, FROM PARK ACROSS PARKING LOT/F STREET, LOOKING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. SOUTH SIDE, FROM PARK ACROSS PARKING LOT/F STREET, LOOKING NORTH. - Oakland Naval Supply Center, Administration Building-Dental Annex-Dispensary, Between E & F Streets, East of Third Street, Oakland, Alameda County, CA

  3. IL-18 and Cutaneous Inflammatory Diseases

    PubMed Central

    Lee, Ji hyun; Cho, Dae Ho; Park, Hyun Jeong

    2015-01-01

    Interleukin (IL)-18, an IL-1 family cytokine, is a pleiotropic immune regulator. IL-18 plays a strong proinflammatory role by inducing interferon (IFN)-γ. Previous studies have implicated IL-18 in the pathogenesis of various diseases. However, it is not well understood biologic activities of IL-18 in the diverse skin diseases. Here, we have reviewed the expression and function of IL-18 in skin diseases including inflammatory diseases. This article provides an evidence-based understanding of the role of IL-18 in skin diseases and its relationship with disease activities. PMID:26690141

  4. Neighborhood Poverty, Park Use, and Park-Based Physical Activity in a Southern California City

    PubMed Central

    Cohen, Deborah; Han, Bing; Derose, Kathryn; Williamson, Stephanie; Marsh, Terry; Rudick, Jodi; McKenzie, Thomas L.

    2013-01-01

    A rich literature indicates that individuals of lower socio-economic status engage in less leisure time physical activity than individuals of higher socio-economic status. However, the source of the difference is believed to be, in part, due to differential access to resources that support physical activity. However, it has not been shown as to whether equal access to parks can mitigate differences in leisure time physical activity. Using systematic direct observation, we quantified physical activity in neighborhood parks in a large Southern California city located in areas with high, medium, and a low percentage of households in poverty. We documented how neighborhood parks are managed and programmed and also interviewed both a sample of park users and a random sample of households within a mile radius of the parks. We found that parks are used less in high-poverty areas compared to medium- and low-poverty area parks, even after accounting for differences in size, staffing, and programming. The strongest correlates of park use were the number of part time staff, the number of supervised and organized programs, and knowing the park staff. Perceptions of safety were not relevant to park use among those interviewed in the park, however it had a small relationship with reported frequency of park use among local residents. Among park users, time spent watching electronic media was negatively correlated with the frequency of visiting the park. Future research should test whether increasing park staffing and programming will lead to increased park use in high-poverty neighborhoods. PMID:23010338

  5. Neighborhood poverty, park use, and park-based physical activity in a Southern California city.

    PubMed

    Cohen, Deborah A; Han, Bing; Derose, Kathryn Pitkin; Williamson, Stephanie; Marsh, Terry; Rudick, Jodi; McKenzie, Thomas L

    2012-12-01

    A rich literature indicates that individuals of lower socio-economic status engage in less leisure time physical activity than individuals of higher socio-economic status. However, the source of the difference is believed to be, in part, due to differential access to resources that support physical activity. However, it has not been shown as to whether equal access to parks can mitigate differences in leisure time physical activity. Using systematic direct observation, we quantified physical activity in neighborhood parks in a large Southern California city located in areas with high, medium, and a low percentage of households in poverty. We documented how neighborhood parks are managed and programmed and also interviewed both a sample of park users and a random sample of households within a mile radius of the parks. We found that parks are used less in high-poverty areas compared to medium- and low-poverty area parks, even after accounting for differences in size, staffing, and programming. The strongest correlates of park use were the number of part time staff, the number of supervised and organized programs, and knowing the park staff. Perceptions of safety were not relevant to park use among those interviewed in the park, however it had a small relationship with reported frequency of park use among local residents. Among park users, time spent watching electronic media was negatively correlated with the frequency of visiting the park. Future research should test whether increasing park staffing and programming will lead to increased park use in high-poverty neighborhoods.

  6. IL TRAPIANTO ORTOTOPICO DEL FEGATO

    PubMed Central

    STARZL, THOMAS E.

    2010-01-01

    E’ormai noto che esiste la possibilità rivoluzionaria di utilizzare il fegato per il trattamento della stadio terminale delle epatopatie. Nel gennaio 1980 si celebra il decimo anna di sopravvivenza con fegato trapiantato (la più lunga della letteratura) di un paziente da noi trattato. Si tratta di uno dei 12 malati sottoposti a trapianto e seguiti per più di 5 anni. La nota positiva di questa tipo di trattamento è rappresentata dall’eccellente tenore di vita che i pazienti conducono e dalla riabilitazione sociale e professionale. La nota negativa è data, invece, dal fatto che i buoni risultati non vengono raggiunti con regolarità e non possono essere previsti con esattezza. In questa breve rassegna considereremo la esperienza da noi fatta presso l’Università di Denver nel Colorado, mettendo in risalto le cause dell’elevata mortalità precoce e le prospettive future di questa mezzo terapeutico. PMID:21572898

  7. 78 FR 14822 - Proposed Information Collection; National Park Service Concessions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-07

    ... National Park Service Proposed Information Collection; National Park Service Concessions AGENCY: National Park Service, Interior. ACTION: Notice; request for comments. SUMMARY: We (National Park Service, NPS... Madonna L. Baucum, Information Collection Clearance Officer, National Park Service, 1201 I Street NW., MS...

  8. 78 FR 44596 - Minor Boundary Revision at Yosemite National Park

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-24

    ... National Park Service Minor Boundary Revision at Yosemite National Park AGENCY: National Park Service, Interior. ACTION: Notification of Boundary Revision. SUMMARY: The boundary of Yosemite National Park is... boundary of Yosemite National Park. DATES: The effective date of this boundary revision is July 24, 2013...

  9. 76 FR 11812 - Gettysburg National Military Park Advisory Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-03

    ... National Park Service Gettysburg National Military Park Advisory Commission AGENCY: National Park Service... Park Advisory Commission. DATES: The public meetings will be held on April 14, 2011 and August 18, 2011... the Gettysburg Battlefield Historic District; Operational Updates on Park Activities which will...

  10. 36 CFR 1253.2 - National Archives at College Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false National Archives at College Park. 1253.2 Section 1253.2 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS... Archives at College Park. The National Archives at College Park is located at 8601 Adelphi Road, College...

  11. 76 FR 77552 - Gettysburg National Military Park Advisory Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-13

    ... National Park Service Gettysburg National Military Park Advisory Commission AGENCY: National Park Service... sets forth the dates of April 19, 2012 and September 6, 2012 of the Gettysburg National Military Park... National Military Park Museum and Visitor Center, 1195 Baltimore Pike, Gettysburg, Pennsylvania 17325...

  12. 36 CFR 7.78 - Harpers Ferry National Historical Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Harpers Ferry National Historical Park. 7.78 Section 7.78 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.78 Harpers Ferry National...

  13. 36 CFR 7.14 - Great Smoky Mountains National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Great Smoky Mountains National Park. 7.14 Section 7.14 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.14 Great Smoky Mountains...

  14. 36 CFR 14.10 - Areas of National Park System.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Areas of National Park System. 14.10 Section 14.10 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR RIGHTS-OF-WAY Nature of Interest § 14.10 Areas of National Park System. (a) The Act of March 3...

  15. 36 CFR 7.14 - Great Smoky Mountains National Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Great Smoky Mountains National Park. 7.14 Section 7.14 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.14 Great Smoky Mountains...

  16. 76 FR 9360 - Kalaupapa National Historical Park Advisory Commission Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-17

    ... National Park Service Kalaupapa National Historical Park Advisory Commission Meeting AGENCY: National Park..., 2011, Meeting of the Kalaupapa National Historical Park Advisory Commission. DATES: The public meeting...). ADDRESSES: The meeting will be held at McVeigh Social Hall, Kalaupapa National Historical Park, Kalaupapa...

  17. 36 CFR 7.14 - Great Smoky Mountains National Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Great Smoky Mountains National Park. 7.14 Section 7.14 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.14 Great Smoky Mountains...

  18. 36 CFR 7.14 - Great Smoky Mountains National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Great Smoky Mountains National Park. 7.14 Section 7.14 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.14 Great Smoky Mountains...

  19. 76 FR 70483 - Gettysburg National Military Park Advisory Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... National Park Service Gettysburg National Military Park Advisory Commission AGENCY: National Park Service... September 6, 2012 of the Gettysburg National Military Park Advisory Commission. DATES: The public meetings... be held at the Ford Education Center in the Gettysburg National Military Park Museum and Visitor...

  20. 36 CFR 14.10 - Areas of National Park System.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Areas of National Park System. 14.10 Section 14.10 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR RIGHTS-OF-WAY Nature of Interest § 14.10 Areas of National Park System. (a) The Act of March 3...

  1. 36 CFR 7.78 - Harpers Ferry National Historical Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Harpers Ferry National Historical Park. 7.78 Section 7.78 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.78 Harpers Ferry National...

  2. 36 CFR 1253.2 - National Archives at College Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false National Archives at College Park. 1253.2 Section 1253.2 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS... Archives at College Park. The National Archives at College Park is located at 8601 Adelphi Road, College...

  3. 36 CFR 14.10 - Areas of National Park System.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Areas of National Park System. 14.10 Section 14.10 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR RIGHTS-OF-WAY Nature of Interest § 14.10 Areas of National Park System. (a) The Act of March 3...

  4. 75 FR 13572 - Gettysburg National Military Park Advisory Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-22

    ... National Park Service Gettysburg National Military Park Advisory Commission AGENCY: National Park Service... dates of the April 7, 2006 and October 5, 2006 meetings of the Gettysburg National Military Park... Park Activities which consists of an update on Gettysburg National Battlefield Museum Foundation and...

  5. 36 CFR 1253.2 - National Archives at College Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false National Archives at College Park. 1253.2 Section 1253.2 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS... Archives at College Park. The National Archives at College Park is located at 8601 Adelphi Road, College...

  6. 36 CFR 7.14 - Great Smoky Mountains National Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Great Smoky Mountains National Park. 7.14 Section 7.14 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.14 Great Smoky Mountains...

  7. 36 CFR 7.78 - Harpers Ferry National Historical Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Harpers Ferry National Historical Park. 7.78 Section 7.78 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.78 Harpers Ferry National...

  8. 75 FR 52969 - National Park System Advisory Board; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-30

    ... National Park Service National Park System Advisory Board; Meeting AGENCY: National Park Service, Interior... Committee Act, 5 U.S.C. Appendix, that the National Park System Advisory Board will meet September 15-16... in the afternoon will tour park sites in the National Capital Region. On September 16, the Board will...

  9. 36 CFR 7.78 - Harpers Ferry National Historical Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Harpers Ferry National Historical Park. 7.78 Section 7.78 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.78 Harpers Ferry National...

  10. 36 CFR 14.10 - Areas of National Park System.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Areas of National Park System. 14.10 Section 14.10 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR RIGHTS-OF-WAY Nature of Interest § 14.10 Areas of National Park System. (a) The Act of March 3...

  11. 36 CFR 14.10 - Areas of National Park System.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Areas of National Park System. 14.10 Section 14.10 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR RIGHTS-OF-WAY Nature of Interest § 14.10 Areas of National Park System. (a) The Act of March 3...

  12. 30 CFR 56.14207 - Parking procedures for unattended equipment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Parking procedures for unattended equipment. 56... Machinery and Equipment Safety Practices and Operational Procedures § 56.14207 Parking procedures for... park position and the parking brake, if provided, is set. When parked on a grade, the wheels or tracks...

  13. 30 CFR 56.14207 - Parking procedures for unattended equipment.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Parking procedures for unattended equipment. 56... Machinery and Equipment Safety Practices and Operational Procedures § 56.14207 Parking procedures for... park position and the parking brake, if provided, is set. When parked on a grade, the wheels or tracks...

  14. 36 CFR 7.78 - Harpers Ferry National Historical Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Harpers Ferry National Historical Park. 7.78 Section 7.78 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.78 Harpers Ferry...

  15. IL2RA — EDRN Public Portal

    Cancer.gov

    The interleukin 2 receptor exists in three forms which differ in their ability to bind interleukin 2. The low affinity form of the receptor is a monomer of IL2RA, the alpha subunit. The alpha/beta subunit heterodimer, formed by IL2RA and IL2RB, is an intermediate affinity form. The alpha/beta/gamma heterotrimer formed by IL2RA, IL2RB, and IL2RG is the high affinity form. IL2RA is normally an integral membrane protein, although soluble IL2RA has been isolated. There are known alternately-spliced versions of IL2RA mRNAs, but their functions are unknown. Mutations in the IL2RA gene are associated with diabetes mellitus insulin-dependent type 10 (IDDM10). Complications of IDDM10 can adversely affect the eyes, kidneys, nerves, and blood vessels.

  16. IL6R — EDRN Public Portal

    Cancer.gov

    The interleukin 6 receptor is a protein complex consisting of two parts: the IL6R (interleukin 6 receptor) subunit and the IL6ST (interleukin 6 signal transducer) subunit. The IL6R subunit binds to IL6 (interleukin 6) with low affinity, but does not transduce a signal. The IL6ST subunit is needed for signal activation. Impaired regulation of IL6 and IL6R have been linked to many diseases, such as multiple myeloma, autoimmune diseases, and prostate cancer. Isoforms encoded by alternatively spliced transcripts have been reported. Activation of the IL6/IL6R/IL6ST complex may lead to the regulation of the immune response, acute-phase reactions, and hematopoiesis.

  17. INEEL Vadose Zone Research Park

    NASA Astrophysics Data System (ADS)

    Heath, G.; Hull, L.; Ansley, S.; Versteeg, R.; Scott, C.; Street, L.

    2003-12-01

    The Vadose Zone Research Park was developed to address mission critical issues related to operations, waste management, and environmental restoration at U. S. Department of Energy (DOE) sites that are located over thick vadose zones. The research park provides instrumentation and facilities for scientists to address vadose zone processes that are important in assessing operational activities, remedial measures, and long-term stewardship of DOE lands. The park, at the Idaho National Engineering and Environmental Laboratory (INEEL), is strategically located along the Big Lost River, an intermittent river, and around two new percolation ponds. This location provides the opportunity to study variable recharge from the river, continuous recharge from the ponds, and the interactions between the two sources. Drilling began in September 2000 and was completed in June 2001. Thirty one wells and instrumented boreholes have been installed at the park to monitor perched water, measure moisture movement, collect water and gas samples, and study intra-well geophysical properties. Nine of the boreholes, ranging in depth from 150 ft to 504 ft below land surface (bls), are instrumented to monitor moisture in the vadose zone. Instruments include: tensiometers, moisture content sensors, suction lysimeters, temperature sensors, gas ports and electrodes for electrical resistance tomography. Electrodes are evenly spaced throughout the borehole with hydrologic instruments concentrated in and near the sedimentary interbeds-discontinuous layers of silts and clays that occur between some basalt flows. Eighteen monitoring wells, ranging in depth from 60 ft to 250 ft bls, are completed with 4 or 6 inch PVC casing, and generally include an electrical resistivity electrode array attached to the casing. Three bore holes are constructed for testing cross-hole ground penetrating radar as well as for testing new nuclear logging tools being designed at the INEEL. The remaining borehole contains only

  18. Amphibians of Olympic National Park

    USGS Publications Warehouse

    ,

    2000-01-01

    Amphibians evolved from fishes about 360 million years ago and were the first vertebrates adapted to life on land. The word amphibian means "double life." It refers to the life history of many amphibians, which spend part of their life in water and part on land. There are three major groups of amphibians: salamanders, frogs, and toads, and caecilians. Salamanders, frogs, and toads can be found in Olympic National Park (ONP), but caecilians live only in tropical regions. Many amphibians are generalist predators, eating almost any prey they can fit into their mouths.

  19. IL-1 receptor accessory protein is an essential component of the IL-1 receptor.

    PubMed

    Cullinan, E B; Kwee, L; Nunes, P; Shuster, D J; Ju, G; McIntyre, K W; Chizzonite, R A; Labow, M A

    1998-11-15

    The recently described IL-1R accessory protein (IL-1R AcP) interacts with IL-1beta and the IL-1 type-IR (IL-1RI), but an essential requirement for IL-1R AcP in IL-1 signaling in vitro has not been established and its role in vivo has not been examined. In this study, IL-1R AcP-deficient mice and fibroblasts were produced and characterized. All IL-1 agonists bound to IL-1R AcP-deficient cells through the type I IL-1R, but failed to activate gene expression through either the nuclear factor-kappaB or AP-1-dependent signaling pathways. Absence of IL-1R AcP differentially affected the affinity for IL-1 ligands. IL-1R AcP-deficient fibroblasts bound murine IL-1alpha and human IL-1R antagonist protein (IL-1Ra) with only moderately reduced affinity when compared with wild-type cells, whereas murine IL-1beta affinity was reduced by 70-fold. IL-1 also failed to produce a biologic response in vivo in IL-1R AcP-deficient mice. These data demonstrate that a type I IL-1R/IL-1R AcP complex is required for signaling by all IL-1 agonists and for high affinity binding by IL-1beta. Finally, IL-1R AcP is an essential signal transducing component of the functional IL-1R and should represent a novel target for blocking IL-1 function in human disease.

  20. The Roles of IL-6, IL-10, and IL-1RA in Obesity and Insulin Resistance in African-Americans

    PubMed Central

    Doumatey, Ayo; Huang, Hanxia; Zhou, Jie; Chen, Guanjie; Shriner, Daniel; Adeyemo, Adebowale

    2011-01-01

    Objective: The aim of the study was to investigate the associations between IL-1 receptor antagonist (IL-1RA), IL-6, IL-10, measures of obesity, and insulin resistance in African-Americans. Research Design and Methods: Nondiabetic participants (n = 1025) of the Howard University Family Study were investigated for associations between serum IL (IL-1RA, IL-6, IL-10), measures of obesity, and insulin resistance, with adjustment for age and sex. Measures of obesity included body mass index, waist circumference, hip circumference, waist-to-hip ratio, and percent fat mass. Insulin resistance was assessed using the homeostasis model assessment of insulin resistance (HOMA-IR). Data were analyzed with R statistical software using linear regression and likelihood ratio tests. Results: IL-1RA and IL-6 were associated with measures of obesity and insulin resistance, explaining 4–12.7% of the variance observed (P values < 0.001). IL-1RA was bimodally distributed and therefore was analyzed based on grouping those with low vs. high IL-1RA levels. High IL-1RA explained up to 20 and 12% of the variance in measures of obesity and HOMA-IR, respectively. Among the IL, only high IL-1RA improved the fit of models regressing HOMA-IR on measures of obesity. In contrast, all measures of obesity improved the fit of models regressing HOMA-IR on IL. IL-10 was not associated with obesity measures or HOMA-IR. Conclusions: High IL-1RA levels and obesity measures are associated with HOMA-IR in this population-based sample of African-Americans. The results suggest that obesity and increased levels of IL-1RA both contribute to the development of insulin resistance. PMID:21956416

  1. Future scenarios of Korea national parks: Delphi survey of Korean parks of experts

    Treesearch

    Byung-kyu Lee; Wilbur F. LaPage

    2003-01-01

    A three-wave Delphi survey of a panel of 40 key experts very knowledgeable of Korean national parks was conducted between February 2001 and March in 2002. In Wave 1, park professionals, environmental Nongovernmental Organizations (NGOs) managers, and a retiree identified the issues the Korean park system is facing. Findings from Wave 1 of the survey were analyzed and...

  2. Pupils and Parks: Environmental Education in National Parks of Developing Countries.

    ERIC Educational Resources Information Center

    Jacobson, Susan K.; Padua, Suzana M.

    1992-01-01

    Describes two conservation education programs that target local primary schools and use national parks in Malaysian Borneo (Kinabalu Park) and central Brazil (Morro do Diabo Park). Both were designed using a comprehensive systems evaluation model and both resulted in cognitive and affective gains for students. (LB)

  3. Parks as Resources for Knowledge in Science (PARKS) National Program Evaluation Final Report.

    ERIC Educational Resources Information Center

    Wiltz, L. Kate

    This document evaluates the Parks as Resources for Knowledge in Science (PARKS) project which supports environmental education in 36 National Parks across the United States and provides curriculum-based learning opportunities that integrate National Science Education Standards for teachers and students. Contents include: (1) "Executive…

  4. 78 FR 22470 - Special Regulations; Areas of the National Park System; Yellowstone National Park; Winter Use

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-16

    ...The National Park Service is proposing this rule to establish a management framework that allows the public to experience the unique winter resources and values at Yellowstone National Park. This rule includes provisions that allow greater flexibility for commercial tour operators, provide mechanisms to make the park cleaner and quieter than what has been authorized during the previous four......

  5. Pupils and Parks: Environmental Education in National Parks of Developing Countries.

    ERIC Educational Resources Information Center

    Jacobson, Susan K.; Padua, Suzana M.

    1992-01-01

    Describes two conservation education programs that target local primary schools and use national parks in Malaysian Borneo (Kinabalu Park) and central Brazil (Morro do Diabo Park). Both were designed using a comprehensive systems evaluation model and both resulted in cognitive and affective gains for students. (LB)

  6. The role of IL-37 in cancer.

    PubMed

    Ding, Vivi A; Zhu, Ziwen; Xiao, Huaping; Wakefield, Mark R; Bai, Qian; Fang, Yujiang

    2016-07-01

    Interleukin 37 (IL-37) is a new member of the IL-1 family which all have a similar β-barrel structure. Since its discovery, IL-37 has been studied extensively in immunological field. It has been established that IL-37 possesses anti-inflammatory characteristics both in innate immune response as well as in acquired immune responses by downregulating pro-inflammatory molecules. This review will discuss the role of IL-37 in immunological processes and neoplastic pathogenesis.

  7. Anti-inflammatory activity of IL-37 in asthmatic children: Correlation with inflammatory cytokines TNF-α, IL-β, IL-6 and IL-17A.

    PubMed

    Charrad, Rihab; Berraïes, Anissa; Hamdi, Besma; Ammar, Jamel; Hamzaoui, Kamel; Hamzaoui, Agnes

    2016-02-01

    The aim of this study was to assess interleukin (IL)-37 production in asthmatic children in serum and induced sputum and to look to the impact of IL-37 on pro-inflammatory cytokines production (TNF-α, IL-6, IL-1β and IL-17). Forty children with well-controlled asthma (20 moderate and 20 mild asthmatics) were studied. IL-37 was measured by ELISA in serum and induced sputum (IS) samples, and compared with 22 age- and sex-matched healthy controls. Real-time quantitative PCR was used to determine IL-37 mRNA expression in induced sputum cells. Induced sputum mononuclear cells from 10 moderate asthmatics and 10 healthy controls were stimulated either with lipopolysaccharides (LPS) or LPS plus recombinant IL-37 (rIL-37) comparing pro-inflammatory cytokines production. TNF-α, IL-1β, IL-6 and IL-17 were measured by RT-PCR and ELISA. The expression of IL-37 mRNA in asthmatic patients was significantly lower than that observed in healthy controls (P=0.0001). IL37 mRNA expression depended on asthma severity. Serum and IS IL-37 levels were significantly lower in asthma patients compared to healthy controls. LPS-stimulated sputum cells from asthma patients produced higher levels of IL-1β, IL-6, and TNF-α than those from HC. Adding rIL-37 suppressed TNF-α, IL-1β and IL-6 production in IS cells. In the same way, stimulating IS CD4(+) T cells in the presence of rIL-37 inhibited IL-17 production both in asthma patients and HC. IL-37 effect on IL-17 was more pronounced in patients than controls. The decrease in IL-37 level observed in IS was found to correlate with disease severity. The increased pro-inflammatory cytokines production from asthma IS cells was abrogated by the addition of rIL-37. IL-37 could be an important cytokine in the control of asthma by suppressing the production of inflammatory cytokines. Copyright © 2015 Elsevier GmbH. All rights reserved.

  8. How active are people in metropolitan parks? An observational study of park visitation in Australia.

    PubMed

    Veitch, Jenny; Carver, Alison; Abbott, Gavin; Giles-Corti, Billie; Timperio, Anna; Salmon, Jo

    2015-07-04

    Parks are generally an under-utilized resource in the community with great potential to enhance levels of physical activity. If parks are to attract more visitors across a broad cross-section of the population and facilitate increased physical activity, research is needed to better understand park visitor characteristics and how visitors spend their time in parks. The Recording and EValuating Activity in a Modified Park (REVAMP) study is a natural experiment monitoring a park upgrade in a low socioeconomic status (SES) neighborhood. This study described the observed baseline characteristics of park visitors (age, sex) and characteristics of visitation (weekday or weekend day, period of the day) and explored how these characteristics were associated with observed park-based physical activity in two metropolitan parks located Melbourne, Australia. Direct observations of park visitors were conducted using a modified version of SOPARC (the System for Observing Play and Recreation in Communities) on four weekdays and four weekend days. During weekdays, observations were conducted every hour from 7:30 am-4:30 pm and on weekend days from 8:30 am-4:30 pm. This equated to a total of 1460 scans across the two parks. Chi-square tests examined bivariate associations between park-based physical activity, and socio-demographic and park visitation characteristics. Logistic regression models examined the odds of being observed engaging in moderate- to vigorous-intensity physical activity relative to lying/sitting/standing according to socio-demographic and park visitation characteristics. In total, 4756 park visitors were observed with the majority visiting on weekend days (87 %) and in the afternoon (41 %). Most visitors (62 %) were lying, sitting or standing, with only 29 % observed engaging in moderate-intensity and 9 % in vigorous-intensity physical activity. Park use differed by time of day, sex, age group, and neighborhood SES. Physical activity was lower for women than men

  9. 75 FR 3488 - Acadia National Park; Bar Harbor, ME; Acadia National Park Advisory Commission; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-21

    ... National Park Service Acadia National Park; Bar Harbor, ME; Acadia National Park Advisory Commission.... 92-463, 86 Stat. 770, 5 U.S.C. App. 1, Sec. 10), that the Acadia National Park Advisory Commission... his designee, on matters relating to the management and development of the park, including but not...

  10. 78 FR 51207 - Kobuk Valley National Park Subsistence Resource Commission (SRC) and the Denali National Park SRC...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-20

    ... National Park Service Kobuk Valley National Park Subsistence Resource Commission (SRC) and the Denali National Park SRC; Meetings AGENCY: National Park Service, Interior. ACTION: Meeting notice. SUMMARY: As required by the Federal Advisory Committee Act (Public Law 92-463, 86 Stat. 770), the National Park Service...

  11. Characterization of IL-1β and two types of IL-1 receptors in miiuy croaker and evolution analysis of IL-1 family.

    PubMed

    Yang, Qiong; Chu, Qing; Zhao, Xueyan; Xu, Tianjun

    2017-04-01

    Interleukin (IL)-1β is a prototypical proinflammatory cytokine that belongs to the IL-1 family. This cytokine possesses two receptor types, namely, IL-1 receptor type I (IL-1RI) and IL-1 receptor type II (IL-1RII). IL-1RI, is an IL-1 receptor that plays a crucial role in immune responses and IL-1RII is a decoy receptor for IL-1β signaling inhibitors in mammals. IL-1β, together with its two types of receptors, has been characterized in mammals and implicated in immunity. However, IL-1β and IL-1 receptors in teleost species have been rarely investigated. In this study three genes, namely, IL-1β, IL-1RI, and IL-1RII, were identified and characterized from miiuy croaker. Structural and comparative analysis revealed that miiuy croaker IL-1β, IL-1RI and IL-1RII, particularly their functional domains, were conservative in most of the species. Simultaneously, synteny phylogenetic analysis indicated that IL-1β and IL-18 were widely distributed in vertebrates and hence might be the ancestors of the IL-1 family. Challenge experiment demonstrated that IL-1β, IL-1RI and IL-1RII expression in miiuy croaker was induced by LPS and poly (I:C). IL-1RI expression was also induced by the overexpressed miiuy croaker IL-1β protein which in cell supernatant, whereas IL-1RII was not induced. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. Mercury contamination from mine and natural sources in Harley Gulch, downstream from the Abbott and Turkey Run Mercury Mines, Lake County, California

    NASA Astrophysics Data System (ADS)

    Hothem, R. L.; Rytuba, J. J.; Goldstein, D.; Brussee, B.

    2011-12-01

    The Abbott and Turkey Run Mercury (Hg) mine area in central California has released Hg tailings into the Harley Gulch watershed since 1862. Harley Gulch flows into Cache Creek which is a significant source of Hg into San Francisco Bay Delta. Thermal mine water effluent emanating from the Turkey Run adit flows into the upper part of the watershed. Despite remediation efforts, Hg tailings and enriched sediment remain in the Harley Gulch wetlands and in the creek downstream from the mine area. Water, sediment, and biota have been sampled from below the mine area to 15 km downstream to the confluence with Cache Creek in order to assess the impact of Hg on water quality and biota. Two previously unrecognized natural sources of Hg in the watershed are connate groundwater with elevated levels of Hg, and biogenic sediment composed of phytoplankton that accumulates in the upper part of the watershed during the dry season. The connate groundwater source contains isotopically-heavy Mg-Ca-Cl-CO3-SO4 water that has elevated concentrations of Ba, W, Ti, and Hg. This water first enters Harley Gulch in the central part of the wetland immediately downstream from the mine area and continues to contribute water downstream for a distance of 1.5 km. It is both chemically and isotopically distinct from the thermal mine water effluent from the Turkey Run adit. The biogenic source consists of blooms of phytoplankton that accumulate to a thickness of up to 0.2 m. Phytoplankton have a large bioaccumulation factor of Hg and monomethyl mercury (MMeHg) that results in a high concentrations of Hg and MMeHg (Hg: 5-25 μg/g, MMeHg 5.2 ng/g) in the biogenic sediment. The tan biogenic sediment at the surface consists of living diatoms and below it is a layer of black reduced biogenic sediment consisting of diatom fragments with micron- to submicron-sized FeS, HgS, and barite grains. Sulfate-reducing bacteria reduce sulfate to sulfide in the pore waters of the biogenic sediment that reacts with

  13. IL-23 dampens the allergic response to Cryptococcus neoformans through IL-17-independent and -dependent mechanisms.

    PubMed

    Szymczak, Wendy A; Sellers, Rani S; Pirofski, Liise-anne

    2012-04-01

    The cytokines IL-23 and IL-17 have been implicated in resistance to cryptococcal disease, but it is not clear whether IL-23-mediated production of IL-17 promotes fungal containment following pulmonary challenge with Cryptococcus neoformans. We used mice lacking IL-23 (IL-23p19(-/-)) or IL-17RA (IL-17RA(-/-)), and wild type (WT) C57BL/6 mice to examine the IL-23/IL-17 axis after intranasal infection with the C. neoformans strain 52D. The absence of IL-23 or IL-17RA had no effect on pulmonary or brain fungal burden at 1 or 6 weeks after infection. However, survival of IL-23p19(-/-) mice was reduced compared to IL-17RA(-/-) mice. IL-I7 production by CD4 T cells and natural killer T (NKT) cells was impaired in IL-23p19(-/-) lungs, but was not completely abolished. Both IL-23p19(-/-) and IL-17RA(-/-) mice exhibited impaired neutrophil recruitment, increased serum levels of IgE and IgG2b, and increased deposition of YM1/YM2 crystals in the lung, but only IL-23p19(-/-) mice developed persistent lung eosinophilia. Although survival of IL-17RA(-/-) and WT mice was similar after 17 weeks of infection, only surviving IL-17RA(-/-) mice exhibited cryptococcal dissemination to the blood. These data demonstrate that IL-23 dampens the allergic response to cryptococcal infection through IL-17-independent suppression of eosinophil recruitment and IL-17-dependent regulation of antibody production and crystal deposition. Furthermore, IL-23, and to a lesser extent IL-17, contribute to disease resistance. Copyright © 2012 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

  14. Limited Presence of IL-22 Binding Protein, a Natural IL-22 Inhibitor, Strengthens Psoriatic Skin Inflammation.

    PubMed

    Martin, Jérôme C; Wolk, Kerstin; Bériou, Gaëlle; Abidi, Ahmed; Witte-Händel, Ellen; Louvet, Cédric; Kokolakis, Georgios; Drujont, Lucile; Dumoutier, Laure; Renauld, Jean-Christophe; Sabat, Robert; Josien, Régis

    2017-05-01

    Psoriasis is a chronic inflammatory disease resulting from dysregulated immune activation associated with a large local secretion of cytokines. Among them, IL-22 largely contributes to epithelial remodeling and inflammation through inhibiting the terminal differentiation of keratinocytes and inducing antimicrobial peptides and selected chemokines. The activity of IL-22 is regulated by IL-22 binding protein (IL-22BP); however, the expression and role of IL-22BP in psoriatic skin has remained unknown so far. Here we showed that nonaffected skin of psoriasis patients displayed lower expression of IL-22BP than skin of healthy controls. Furthermore, the strong IL-22 increase in lesional psoriatic skin was accompanied by a moderate induction of IL-22BP. To investigate the role of IL-22BP in controlling IL-22 during skin inflammation, we used imiquimod-induced skin disease in rodents and showed that rats with genetic IL-22BP deficiency (Il22ra2(-/-)) displayed exacerbated disease that associated with enhanced expression of IL-22-inducible antimicrobial peptides. We further recapitulated these findings in mice injected with an anti-IL-22BP neutralizing Ab. Hypothesizing that the IL-22/IL-22BP expression ratio reflects the level of bioactive IL-22 in psoriasis skin, we found positive correlations with the expression of IL-22-inducible molecules (IL-20, IL-24, IL-36γ, CXCL1, and BD2) in keratinocytes. Finally, we observed that serum IL-22/IL-22BP protein ratio strongly correlated with psoriasis severity. In conclusion, we propose that although IL-22BP can control deleterious actions of IL-22 in the skin, its limited production prevents a sufficient neutralization of IL-22 and contributes to the development and maintenance of epidermal alterations in psoriasis. Copyright © 2017 by The American Association of Immunologists, Inc.

  15. Cratylia mollis 1, 4 Lectin: A New Biotechnological Tool in IL-6, IL-17A, IL-22, and IL-23 Induction and Generation of Immunological Memory

    PubMed Central

    de Oliveira, Priscilla Stela Santana; Rêgo, Moacyr Jesus Barreto de Melo; da Silva, Rafael Ramos; Cavalcanti, Mariana Brayner; Galdino, Suely Lins; Correia, Maria Tereza dos Santos; Coelho, Luana Cassandra Breitenbach Barroso; Pitta, Maira Galdino da Rocha

    2013-01-01

    Cratylia mollis lectin has already established cytokine induction in Th1 and Th2 pathways. Thereby, this study aimed to evaluate Cramoll 1, 4 in IL-6, IL-17A, IL-22, and IL-23 induction as well as analyze immunologic memory mechanism by reinducing lymphocyte stimulation. Initially we performed a screening in cultured splenocytes where Cramoll 1, 4 stimulated IL-6 production 5x more than ConA (P < 0.05). The same behavior was observed with IL-22 where the increase was greater than 4x. Nevertheless, IL-17A induction was similar for both lectins. In PBMCs, the same splenocytes course was observed for IL-6 and IL-17A. Concerning the stimulation of IL-22 and IL-23 Cramoll 1, 4 was more efficient than ConA in cytokines stimulation mainly in IL-23 (P < 0.01). Analyzing reinduced lymphocyte stimulation, IL-17A production was higher (P < 0.001) when the first stimulus was realized with Cramoll 1, 4 at 1 μg/mL and the second at 5 μg/mL. IL-22 shows significant differences (P < 0.01) at the same condition. Nevertheless, IL-23 revels the best response when the first stimuli was realized with Cramoll1, 4 at 100 ng/mL and the second with 5 μg/mL. We conclude that the Cramoll 1, 4 is able to induce IL-6, IL-17A, IL-22, and IL-23 cytokines in vitro better than Concavalin A, besides immunologic memory generation, being a potential biotechnological tool in Th17 pathway studies. PMID:23586026

  16. IL-2 and IL-4 counteract budesonide inhibition of GM-CSF and IL-10, but not of IL-8, IL-12 or TNF-α production by human mononuclear blood cells

    PubMed Central

    Larsson, Susanne; Löfdahl, Claes-Göran; Linden, Margareta

    1999-01-01

    The combination of interleukin-2 (IL-2) and IL-4 reduces the inhibitory effects of glucocorticoids on granulocytemacrophage colonystimulating factor (GM-CSF) production, in agreement with the hypothesis that this combination causes glucocorticoid resistance. Whether a general cytokine resistance to glucocorticoids is induced by IL-2 and IL-4 has not been reported. Mononuclear blood cells from healthy individuals were pretreated with IL-2, IL-4, or IL-2+ IL-4 (31.3–500 U ml−1) for 48 h, prior to lipopolysaccharide (LPS; 10 ng ml−1; 20 h) and budesonide addition. Cytokine levels in the supernatants were analysed using specific immunoassays. DNA content was analysed to estimate cell numbers. GM-CSF production was totally inhibited by budesonide at 10−8 M in vehicle treated cultures, while IL-10 was inhibited to 33.4±4.3% of control. IL-2, IL-4, or IL-2+IL-4 reduced the inhibitory effects of budesonide on GM-CSF to similar levels (23.7±6.7, 31.6±8.5 and 35.1±4.3% of control, respectively). IL-2, IL-4, or IL-2+IL-4 also reduced the inhibitory effects of budesonide on IL-10 production (46.5±6.6, 55.9±7.3%, and 68.3±9.9% of control, respectively). In contrast, IL-8, IL-12 and TNF-α production did not become resistant to budesonide. Thus, glucocorticoid resistance induced by IL-2 and IL-4 is not general at the cytokine production level. While the glucocorticoid sensitivity of GM-CSF and IL-10 production decreased, the sensitivity of IL-8, IL-12 or TNF-α production was unchanged. Also, the mixture of IL-2 and IL-4 is not crucial for induction of glucocorticoid resistance of GM-CSF production. PMID:10433506

  17. Role of IL-38 and Its Related Cytokines in Inflammation

    PubMed Central

    Yuan, Xianli; Peng, Xiao; Li, Yan; Li, Mingcai

    2015-01-01

    Interleukin- (IL-) 38 is a recently discovered cytokine and is the tenth member of the IL-1 cytokine family. IL-38 shares structural features with IL-1 receptor antagonist (IL-1Ra) and IL-36Ra. IL-36R is the specific receptor of IL-38, a partial receptor antagonist of IL-36. IL-38 inhibits the production of T-cell cytokines IL-17 and IL-22. IL-38 also inhibits the production of IL-8 induced by IL-36γ, thus inhibiting inflammatory responses. IL-38-related cytokines, including IL-1Ra and IL-36Ra, are involved in the regulation of inflammation and immune responses. The study of IL-38 and IL-38-related cytokines might provide new insights for developing anti-inflammatory treatments in the near future. PMID:25873772

  18. A reliability assessment of a direct-observation park evaluation tool: the parks, activity and recreation among kids (PARK) tool.

    PubMed

    Bird, Madeleine E; Datta, Geetanjali D; van Hulst, Andraea; Kestens, Yan; Barnett, Tracie A

    2015-09-17

    Parks are increasingly being viewed as a resource that may influence youth obesity and physical activity (PA). Assessing park quality can be challenging as few tools assess park characteristics geared towards youth PA. Additionally, no studies have compared reliability estimates of items assessed in different countries, hindering aims towards generalizable park audit items. Finally, new satellite imaging technology is allowing for desktop identification of parks, however it remains unclear how this compares to direct observation park identification. The purpose of this study is 1) to describe the development and reliability of a youth-oriented direct-observation park audit tool tested in Montreal, Canada, and; 2) to compare reliability estimates of items with those drawn from a tool previously tested in Perth, Australia, with those same items tested in Montreal, Canada. Items were drawn and adapted from two existing tools and 13 new items were newly developed for a total of 92 items. Parks were pre-identified using a GIS software and then verified and audited on-site by observers. A total of 576 parks were evaluated. Cohen's kappa and percent agreement were used to assess the inter- and intra-rater reliability of each item. Inter-rater reliabilities of 17 items drawn from a tool previously tested in Australia were compared. Eighty-six percent of items had ≥ 75 % agreement and 83 % had kappa coefficients between 0.41 and 1. Among 40 test-retest episodes kappa agreement was relatively high (≥ 0.40) for all but four items. Percent agreement was excellent (≥ 75 % agreement) for all but eight items. Inter-rater reliability estimates of the 17 items tested in Montreal and Perth were of similar magnitude. The tool is generally reliable and can be used to assess park characteristics that may be associated with youth PA. The items tested in Montreal and Perth are likely generalizable to other urban environments.

  19. Dreaming of a Better ILS

    ERIC Educational Resources Information Center

    Bahr, Ellen

    2007-01-01

    What would technological librarians like to see in the next generation of Integrated Library Systems (ILS)? This question was asked of several well- known library technology experts, and their responses are presented in this article. Survey respondents expressed a clear desire for the following features and functionality: (1) Direct, read-only…

  20. Brain IL-6 and autism.

    PubMed

    Wei, H; Alberts, I; Li, X

    2013-11-12

    Autism is a severe neurodevelopmental disorder characterized by impairments in social interaction, deficits in verbal and non-verbal communication, and repetitive behavior and restricted interests. Emerging evidence suggests that aberrant neuroimmune responses may contribute to phenotypic deficits and could be appropriate targets for pharmacologic intervention. Interleukin (IL)-6, one of the most important neuroimmune factors, has been shown to be involved in physiological brain development and in several neurological disorders. For instance, findings from postmortem and animal studies suggest that brain IL-6 is an important mediator of autism-like behaviors. In this review, a possible pathological mechanism behind autism is proposed, which suggests that IL-6 elevation in the brain, caused by the activated glia and/or maternal immune activation, could be an important inflammatory cytokine response involved in the mediation of autism-like behaviors through impairments of neuroanatomical structures and neuronal plasticity. Further studies to investigate whether IL-6 could be used for therapeutic interventions in autism would be of great significance.