Dermoscopy of pigmented lesions on mucocutaneous junction and mucous membrane.

PubMed

Lin, J; Koga, H; Takata, M; Saida, T

2009-12-01

The dermoscopic features of pigmented lesions on the mucocutaneous junction and mucous membrane are different from those on hairy skin. Differentiation between benign lesions and malignant melanomas of these sites is often difficult. To define the dermoscopic patterns of lesions on the mucocutaneous junction and mucous membrane, and assess the applicability of standard dermoscopic algorithms to these lesions. An unselected consecutive series of 40 lesions on the mucocutaneous junction and mucous membrane was studied. All the lesions were imaged using dermoscopy devices, analysed for dermoscopic patterns and scored with algorithms including the ABCD rule, Menzies method, 7-point checklist, 3-point checklist and the CASH algorithm. Benign pigmented lesions of the mucocutaneous junction and mucous membrane frequently presented a dotted-globular pattern (25%), a homogeneous pattern (25%), a fish scale-like pattern (18.8%) and a hyphal pattern (18.8%), while melanomas of these sites showed a multicomponent pattern (75%) and a homogeneous pattern (25%). The fish scale-like pattern and hyphal pattern were considered to be variants of the ring-like pattern. The sensitivities of the ABCD rule, Menzies method, 7-point checklist, 3-point checklist and CASH algorithm in diagnosing mucosal melanomas were 100%, 100%, 63%, 88% and 100%; and the specificities were 100%, 94%, 100%, 94% and 100%, respectively. The ring-like pattern and its variants (fish scale-like pattern and hyphal pattern) are frequently observed as well as the dotted-globular pattern and homogeneous pattern in mucosal melanotic macules. The algorithms for pigmented lesions on hairy skin also apply to those on the mucocutaneous junction and mucous membrane with high sensitivity and specificity.

Role of NH{sub 2}-terminal hydrophobic motif in the subcellular localization of ATP-binding cassette protein subfamily D: Common features in eukaryotic organisms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Asaka; Asahina, Kota; Okamoto, Takumi

Highlights: • ABCD proteins classifies based on with or without NH{sub 2}-terminal hydrophobic segment. • The ABCD proteins with the segment are targeted peroxisomes. • The ABCD proteins without the segment are targeted to the endoplasmic reticulum. • The role of the segment in organelle targeting is conserved in eukaryotic organisms. - Abstract: In mammals, four ATP-binding cassette (ABC) proteins belonging to subfamily D have been identified. ABCD1–3 possesses the NH{sub 2}-terminal hydrophobic region and are targeted to peroxisomes, while ABCD4 lacking the region is targeted to the endoplasmic reticulum (ER). Based on hydropathy plot analysis, we found that severalmore » eukaryotes have ABCD protein homologs lacking the NH{sub 2}-terminal hydrophobic segment (H0 motif). To investigate whether the role of the NH{sub 2}-terminal H0 motif in subcellular localization is conserved across species, we expressed ABCD proteins from several species (metazoan, plant and fungi) in fusion with GFP in CHO cells and examined their subcellular localization. ABCD proteins possessing the NH{sub 2}-terminal H0 motif were localized to peroxisomes, while ABCD proteins lacking this region lost this capacity. In addition, the deletion of the NH{sub 2}-terminal H0 motif of ABCD protein resulted in their localization to the ER. These results suggest that the role of the NH{sub 2}-terminal H0 motif in organelle targeting is widely conserved in living organisms.« less

Predictive Structure and Topology of Peroxisomal ATP-Binding Cassette (ABC) Transporters

PubMed Central

Andreoletti, Pierre; Raas, Quentin; Gondcaille, Catherine; Cherkaoui-Malki, Mustapha; Trompier, Doriane; Savary, Stéphane

2017-01-01

The peroxisomal ATP-binding Cassette (ABC) transporters, which are called ABCD1, ABCD2 and ABCD3, are transmembrane proteins involved in the transport of various lipids that allow their degradation inside the organelle. Defective ABCD1 leads to the accumulation of very long-chain fatty acids and is associated with a complex and severe neurodegenerative disorder called X-linked adrenoleukodystrophy (X-ALD). Although the nucleotide-binding domain is highly conserved and characterized within the ABC transporters family, solid data are missing for the transmembrane domain (TMD) of ABCD proteins. The lack of a clear consensus on the secondary and tertiary structure of the TMDs weakens any structure-function hypothesis based on the very diverse ABCD1 mutations found in X-ALD patients. Therefore, we first reinvestigated thoroughly the structure-function data available and performed refined alignments of ABCD protein sequences. Based on the 2.85  Å resolution crystal structure of the mitochondrial ABC transporter ABCB10, here we propose a structural model of peroxisomal ABCD proteins that specifies the position of the transmembrane and coupling helices, and highlight functional motifs and putative important amino acid residues. PMID:28737695

Barley has two peroxisomal ABC transporters with multiple functions in β-oxidation

PubMed Central

Mendiondo, Guillermina M.; Medhurst, Anne; van Roermund, Carlo W.; Zhang, Xuebin; Devonshire, Jean; Scholefield, Duncan; Fernández, José; Axcell, Barry; Ramsay, Luke; Waterham, Hans R.; Waugh, Robbie; Theodoulou, Frederica L.; Holdsworth, Michael J.

2014-01-01

In oilseed plants, peroxisomal β-oxidation functions not only in lipid catabolism but also in jasmonate biosynthesis and metabolism of pro-auxins. Subfamily D ATP-binding cassette (ABC) transporters mediate import of β-oxidation substrates into the peroxisome, and the Arabidopsis ABCD protein, COMATOSE (CTS), is essential for this function. Here, the roles of peroxisomal ABCD transporters were investigated in barley, where the main storage compound is starch. Barley has two CTS homologues, designated HvABCD1 and HvABCD2, which are widely expressed and present in embryo and aleurone tissues during germination. Suppression of both genes in barley RNA interference (RNAi) lines indicated roles in metabolism of 2,4-dichlorophenoxybutyrate (2,4-DB) and indole butyric acid (IBA), jasmonate biosynthesis, and determination of grain size. Transformation of the Arabidopsis cts-1 null mutant with HvABCD1 and HvABCD2 confirmed these findings. HvABCD2 partially or completely complemented all tested phenotypes of cts-1. In contrast, HvABCD1 failed to complement the germination and establishment phenotypes of cts-1 but increased the sensitivity of hypocotyls to 100 μM IBA and partially complemented the seed size phenotype. HvABCD1 also partially complemented the yeast pxa1/pxa2Δ mutant for fatty acid β-oxidation. It is concluded that the core biochemical functions of peroxisomal ABC transporters are largely conserved between oilseeds and cereals but that their physiological roles and importance may differ. PMID:24913629

Genome-Wide Search for Genes Required for Bifidobacterial Growth under Iron-Limitation

PubMed Central

Lanigan, Noreen; Bottacini, Francesca; Casey, Pat G.; O'Connell Motherway, Mary; van Sinderen, Douwe

2017-01-01

Bacteria evolved over millennia in the presence of the vital micronutrient iron. Iron is involved in numerous processes within the cell and is essential for nearly all living organisms. The importance of iron to the survival of bacteria is obvious from the large variety of mechanisms by which iron may be acquired from the environment. Random mutagenesis and global gene expression profiling led to the identification of a number of genes, which are essential for Bifidobacterium breve UCC2003 survival under iron-restrictive conditions. These genes encode, among others, Fe-S cluster-associated proteins, a possible ferric iron reductase, a number of cell wall-associated proteins, and various DNA replication and repair proteins. In addition, our study identified several presumed iron uptake systems which were shown to be essential for B. breve UCC2003 growth under conditions of either ferric and/or ferrous iron chelation. Of these, two gene clusters encoding putative iron-uptake systems, bfeUO and sifABCDE, were further characterised, indicating that sifABCDE is involved in ferrous iron transport, while the bfeUO-encoded transport system imports both ferrous and ferric iron. Transcription studies showed that bfeUO and sifABCDE constitute two separate transcriptional units that are induced upon dipyridyl-mediated iron limitation. In the anaerobic gastrointestinal environment ferrous iron is presumed to be of most relevance, though a mutation in the sifABCDE cluster does not affect B. breve UCC2003's ability to colonise the gut of a murine model. PMID:28620359

Impact of an ABCDE team triage process combined with public guidance on the division of work in an emergency department.

PubMed

Kantonen, Jarmo; Lloyd, Robert; Mattila, Juho; Kauppila, Timo; Menezes, Ricardo

2015-06-01

To study the effects of applying an emergency department (ED) triage system, combined with extensive publicity in local media about the "right" use of emergency services, on the division of work between ED nurses and general practitioners (GPs). An observational and quasi-experimental study based on before-after comparisons. Implementation of the ABCDE triage system in a Finnish combined ED where secondary care is adjacent, and in a traditional primary care ED where secondary care is located elsewhere. GPs and nurses from two different primary care EDs. Numbers of monthly visits to different professional groups before and after intervention in the studied primary care EDs and numbers of monthly visits to doctors in the local secondary care ED. The beginning of the triage process increased temporarily the number of independent consultations and patient record entries by ED nurses in both types of studied primary care EDs and reduced the number of patient visits to a doctor compared with previous years but had no effect on doctor visits in the adjacent secondary care ED. No further decrease in the number of nurse or GP visits was observed by inhibiting the entrance of non-urgent patients. The ABCDE triage system combined with public guidance may reduce non-urgent patient visits to doctors in different kinds of primary care EDs without increasing visits in the secondary care ED. However, the additional work to implement the ABCDE system is mainly directed to nurses, which may pose a challenge for staffing.

Architecture for an advanced biomedical collaboration domain for the European paediatric cancer research community (ABCD-4-E).

PubMed

Nitzlnader, Michael; Falgenhauer, Markus; Gossy, Christian; Schreier, Günter

2015-01-01

Today, progress in biomedical research often depends on large, interdisciplinary research projects and tailored information and communication technology (ICT) support. In the context of the European Network for Cancer Research in Children and Adolescents (ENCCA) project the exchange of data between data source (Source Domain) and data consumer (Consumer Domain) systems in a distributed computing environment needs to be facilitated. This work presents the requirements and the corresponding solution architecture of the Advanced Biomedical Collaboration Domain for Europe (ABCD-4-E). The proposed concept utilises public as well as private cloud systems, the Integrating the Healthcare Enterprise (IHE) framework and web-based applications to provide the core capabilities in accordance with privacy and security needs. The utility of crucial parts of the concept was evaluated by prototypic implementation. A discussion of the design indicates that the requirements of ENCCA are fully met. A whole system demonstration is currently being prepared to verify that ABCD-4-E has the potential to evolve into a domain-bridging collaboration platform in the future.

Reducing time-to-unit among patients referred to an outpatient stroke assessment unit with a novel triage process: a prospective cohort study.

PubMed

Bibok, Maximilian B; Votova, Kristine; Balshaw, Robert F; Lesperance, Mary L; Croteau, Nicole S; Trivedi, Anurag; Morrison, Jaclyn; Sedgwick, Colin; Penn, Andrew M

2018-02-27

To evaluate the performance of a novel triage system for Transient Ischemic Attack (TIA) units built upon an existent clinical prediction rule (CPR) to reduce time to unit arrival, relative to the time of symptom onset, for true TIA and minor stroke patients. Differentiating between true and false TIA/minor stroke cases (mimics) is necessary for effective triage as medical intervention for true TIA/minor stroke is time-sensitive and TIA unit spots are a finite resource. Prospective cohort study design utilizing patient referral data and TIA unit arrival times from a regional fast-track TIA unit on Vancouver Island, Canada, accepting referrals from emergency departments (ED) and general practice (GP). Historical referral cohort (N = 2942) from May 2013-Oct 2014 was triaged using the ABCD2 score; prospective referral cohort (N = 2929) from Nov 2014-Apr 2016 was triaged using the novel system. A retrospective survival curve analysis, censored at 28 days to unit arrival, was used to compare days to unit arrival from event date between cohort patients matched by low (0-3), moderate (4-5) and high (6-7) ABCD2 scores. Survival curve analysis indicated that using the novel triage system, prospectively referred TIA/minor stroke patients with low and moderate ABCD2 scores arrived at the unit 2 and 1 day earlier than matched historical patients, respectively. The novel triage process is associated with a reduction in time to unit arrival from symptom onset for referred true TIA/minor stroke patients with low and moderate ABCD2 scores.

Algebraic approach to characterizing paraxial optical systems.

PubMed

Wittig, K; Giesen, A; Hügel, H

1994-06-20

The paraxial propagation formalism for ABCD systems is reviewed and written in terms of quantum mechanics. This formalism shows that the propagation based on the Collins integral can be generalized so that, in addition, the problem of beam quality degradation that is due to aberrations can be treated in a natural way. Moreover, because this formalism is well elaborated and reduces the problem of propagation to simple algebraic calculations, it seems to be less complicated than other approaches. This can be demonstrated with an easy and unitary derivation of several results, which were obtained with different approaches, in each case matched to the specific problem. It is first shown how the canonical decomposition of arbitrary (also complex) ABCD matrices introduced by Siegman [Lasers, 2nd ed. (Oxford U. Press, London, 1986)] can be used to establish the group structure of geometric optics on the space of optical wave functions. This result is then used to derive the propagation law for arbitrary moments in eneral ABCD systems. Finally a proper generalization to nonparaxial propagation operators that allows us to treat arbitrary aberration effects with respect to their influence on beam quality degradation is presented.

A UNIMARC Bibliographic Format Database for ABCD

ERIC Educational Resources Information Center

Megnigbeto, Eustache

2012-01-01

Purpose: ABCD is a web-based open and free software suite for library management derived from the UNESCO CDS/ISIS software technology. The first version was launched officially in December 2009 with a MARC 21 bibliographic format database. This paper aims to detail the building of the UNIMARC bibliographic format database for ABCD.…

Translocation of the ABC transporter ABCD4 from the endoplasmic reticulum to lysosomes requires the escort protein LMBD1.

PubMed

Kawaguchi, Kosuke; Okamoto, Takumi; Morita, Masashi; Imanaka, Tsuneo

2016-07-26

We previously demonstrated that ABCD4 does not localize to peroxisomes but rather, the endoplasmic reticulum (ER), because it lacks the NH2-terminal hydrophilic region required for peroxisomal targeting. It was recently reported that mutations in ABCD4 result in a failure to release vitamin B12 from lysosomes. A similar phenotype is caused by mutations in LMBRD1, which encodes the lysosomal membrane protein LMBD1. These findings suggested to us that ABCD4 translocated from the ER to lysosomes in association with LMBD1. In this report, it is demonstrated that ABCD4 interacts with LMBD1 and then localizes to lysosomes, and this translocation depends on the lysosomal targeting ability of LMBD1. Furthermore, endogenous ABCD4 was localized to both lysosomes and the ER, and its lysosomal localization was disturbed by knockout of LMBRD1. To the best of our knowledge, this is the first report demonstrating that the subcellular localization of the ABC transporter is determined by its association with an adaptor protein.

Affect, Behavior, Cognition, and Desire in the Big Five: An Analysis of Item Content and Structure

PubMed Central

Wilt, Joshua; Revelle, William

2015-01-01

Personality psychology is concerned with affect (A), behavior (B), cognition (C) and desire (D), and personality traits have been defined conceptually as abstractions used to either explain or summarize coherent ABC (and sometimes D) patterns over time and space. However, this conceptual definition of traits has not been reflected in their operationalization, possibly resulting in theoretical and practical limitations to current trait inventories. Thus, the goal of this project was to determine the affective, behavioral, cognitive and desire (ABCD) components of Big-Five personality traits. The first study assessed the ABCD content of items measuring Big-Five traits in order to determine the ABCD composition of traits and identify items measuring relatively high amounts of only one ABCD content. The second study examined the correlational structure of scales constructed from items assessing ABCD content via a large, web-based study. An assessment of Big-Five traits that delineates ABCD components of each trait is presented, and the discussion focuses on how this assessment builds upon current approaches of assessing personality. PMID:26279606

Characterization of human ATP-binding cassette protein subfamily D reconstituted into proteoliposomes.

PubMed

Okamoto, Takumi; Kawaguchi, Kosuke; Watanabe, Shiro; Agustina, Rina; Ikejima, Toshiki; Ikeda, Keisuke; Nakano, Minoru; Morita, Masashi; Imanaka, Tsuneo

2018-02-19

In mammals, four ATP-binding cassette (ABC) proteins belonging to subfamily D have been identified. ABCD1‒3 are located on peroxisomal membrane and play an important role in the transportation of various fatty acid-CoA derivatives, including very long chain fatty acid-CoA, into peroxisomes. ABCD4 is located on lysosomal membrane and is suggested to be involved in the transport of vitamin B 12 from lysosomes to the cytosol. However, the precise transport mechanism by which these ABC transporters facilitate the import or export of substrate has yet to be well elucidated. In this study, the overexpression of human ABCD1‒4 in the methylotrophic yeast Pichia pastoris and a purification procedure were developed. The detergent-solubilized proteins were reconstituted into liposomes. ABCD1‒4 displayed stable ATPase activity, which was inhibited by AlF 3 . Furthermore, ABCD1‒4 were found to possess an equal levels of acyl-CoA thioesterase activity. Proteoliposomes is expected to be an aid in the further biochemical characterization of ABCD transporters. Copyright © 2018 Elsevier Inc. All rights reserved.

Identification of the Regulator Gene Responsible for the Acetone-Responsive Expression of the Binuclear Iron Monooxygenase Gene Cluster in Mycobacteria ▿

PubMed Central

Furuya, Toshiki; Hirose, Satomi; Semba, Hisashi; Kino, Kuniki

2011-01-01

The mimABCD gene cluster encodes the binuclear iron monooxygenase that oxidizes propane and phenol in Mycobacterium smegmatis strain MC2 155 and Mycobacterium goodii strain 12523. Interestingly, expression of the mimABCD gene cluster is induced by acetone. In this study, we investigated the regulator gene responsible for this acetone-responsive expression. In the genome sequence of M. smegmatis strain MC2 155, the mimABCD gene cluster is preceded by a gene designated mimR, which is divergently transcribed. Sequence analysis revealed that MimR exhibits amino acid similarity with the NtrC family of transcriptional activators, including AcxR and AcoR, which are involved in acetone and acetoin metabolism, respectively. Unexpectedly, many homologs of the mimR gene were also found in the sequenced genomes of actinomycetes. A plasmid carrying a transcriptional fusion of the intergenic region between the mimR and mimA genes with a promoterless green fluorescent protein (GFP) gene was constructed and introduced into M. smegmatis strain MC2 155. Using a GFP reporter system, we confirmed by deletion and complementation analyses that the mimR gene product is the positive regulator of the mimABCD gene cluster expression that is responsive to acetone. M. goodii strain 12523 also utilized the same regulatory system as M. smegmatis strain MC2 155. Although transcriptional activators of the NtrC family generally control transcription using the σ54 factor, a gene encoding the σ54 factor was absent from the genome sequence of M. smegmatis strain MC2 155. These results suggest the presence of a novel regulatory system in actinomycetes, including mycobacteria. PMID:21856847

The utility of twins in developmental cognitive neuroscience research: How twins strengthen the ABCD research design.

PubMed

Iacono, William G; Heath, Andrew C; Hewitt, John K; Neale, Michael C; Banich, Marie T; Luciana, Monica M; Madden, Pamela A; Barch, Deanna M; Bjork, James M

2018-08-01

The ABCD twin study will elucidate the genetic and environmental contributions to a wide range of mental and physical health outcomes in children, including substance use, brain and behavioral development, and their interrelationship. Comparisons within and between monozygotic and dizygotic twin pairs, further powered by multiple assessments, provide information about genetic and environmental contributions to developmental associations, and enable stronger tests of causal hypotheses, than do comparisons involving unrelated children. Thus a sub-study of 800 pairs of same-sex twins was embedded within the overall Adolescent Brain and Cognitive Development (ABCD) design. The ABCD Twin Hub comprises four leading centers for twin research in Minnesota, Colorado, Virginia, and Missouri. Each site is enrolling 200 twin pairs, as well as singletons. The twins are recruited from registries of all twin births in each State during 2006-2008. Singletons at each site are recruited following the same school-based procedures as the rest of the ABCD study. This paper describes the background and rationale for the ABCD twin study, the ascertainment of twin pairs and implementation strategy at each site, and the details of the proposed analytic strategies to quantify genetic and environmental influences and test hypotheses critical to the aims of the ABCD study. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

"Now I Know My ABCDs": Asset-Based Community Development with School Children in Ethiopia

ERIC Educational Resources Information Center

Johnson Butterfield, Alice K.; Yeneabat, Mulu; Moxley, David P.

2016-01-01

Asset-based community development (ABCD) is a promising practice for communities to engage in self-determination through the efforts residents invest in identifying community assets, framing and documenting the issues communities face, and taking action to advance quality of life. The ABCD literature does not report on the application of ABCD…

Metabolic Flux Analysis of the Synechocystis sp. PCC 6803 ΔnrtABCD Mutant Reveals a Mechanism for Metabolic Adaptation to Nitrogen-Limited Conditions.

PubMed

Nakajima, Tsubasa; Yoshikawa, Katsunori; Toya, Yoshihiro; Matsuda, Fumio; Shimizu, Hiroshi

2017-03-01

Metabolic flux redirection during nitrogen-limited growth was investigated in the Synechocystis sp. PCC 6803 glucose-tolerant (GT) strain under photoautotrophic conditions by isotopically non-stationary metabolic flux analysis (INST-MFA). A ΔnrtABCD mutant of Synechocystis sp. PCC 6803 was constructed to reproduce phenotypes arising during nitrogen starvation. The ΔnrtABCD mutant and the wild-type GT strain were cultured under photoautotrophic conditions by a photobioreactor. Intracellular metabolites were labeled over a time course using NaH13CO3 as a carbon source. Based on these data, the metabolic flux distributions in the wild-type and ΔnrtABCD cells were estimated by INST-MFA. The wild-type GT and ΔnrtABCD strains displayed similar distribution patterns, although the absolute levels of metabolic flux were lower in ΔnrtABCD. Furthermore, the relative flux levels for glycogen metabolism, anaplerotic reactions and the oxidative pentose phosphate pathway were increased in ΔnrtABCD. This was probably due to the increased expression of enzyme genes that respond to nitrogen depletion. Additionally, we found that the ratio of ATP/NADPH demand increased slightly in the ΔnrtABCD mutant. These results indicated that futile ATP consumption increases under nitrogen-limited conditions because the Calvin-Benson cycle and the oxidative pentose phosphate pathway form a metabolic futile cycle that consumes ATP without CO2 fixation and NADPH regeneration. © The Author 2017. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

A Glycine Betaine Importer Limits Salmonella Stress Resistance and Tissue Colonization by Reducing Trehalose Production

PubMed Central

Pilonieta, M. Carolina; Nagy, Toni A.; Jorgensen, Dana R.; Detweiler, Corrella S.

2012-01-01

SUMMARY Mechanisms by which Salmonella establish chronic infections are not well understood. Microbes respond to stress by importing or producing compatible solutes, small molecules that stabilize proteins and lipids. The Salmonella locus opuABCD (also called OpuC) encodes a predicted importer of the compatible solute glycine betaine. Under stress conditions, if glycine betaine cannot be imported, S. enterica produce the disaccharide trehalose, a highly effective compatible solute. We demonstrate that strains lacking opuABCD accumulate more trehalose under stress conditions than wild-type strains. ΔopuABCD mutant strains are more resistant to high salt, low pH and hydrogen peroxide, conditions that mimic aspects of innate immunity, in a trehalose-dependent manner. In addition, ΔopuABCD mutant strains require the trehalose production genes to out-compete wild-type strains in mice and macrophages. These data suggest that in the absence of opuABCD, trehalose accumulation increases bacterial resistance to stress in broth and mice. Thus, opuABCD reduces bacterial colonization via a mechanism that limits trehalose production. Mechanisms by which microbes limit disease may reveal novel pathways as therapeutic targets. PMID:22375627

Airyprime beams and their propagation characteristics

NASA Astrophysics Data System (ADS)

Zhou, Guoquan; Chen, Ruipin; Ru, Guoyun

2014-02-01

A type of Airyprime beam is introduced in this document. An analytical expression of Airyprime beams passing through a separable ABCD paraxial optical system is derived. The beam propagation factor of the Airyprime beam is proved to be 3.676. An analytical expression of the kurtosis parameter of an Airyprime beam passing through a separable ABCD paraxial optical system is also presented. The kurtosis parameter of the Airyprime beam passing through a separable ABCD paraxial optical system depends on the two ratios B/(Azrx) and B/(Azry). As a numerical example, the propagation characteristics of an Airyprime beam is demonstrated in free space. In the source plane, the Airyprime beam has nine lobes, one of which is the central dominant lobe. In the far field, the Airyprime beam becomes a dark-hollow beam with four uniform lobes. The evolvement of an Airyprime beam propagating in free space is well exhibited. Upon propagation, the intensity distribution of the Airyprime beam becomes flatter and the kurtosis parameter decreases from the maximum value 2.973 to a saturated value 1.302. The Airyprime beam is also compared with the second-order elegant Hermite-Gaussian beam. The novel propagation characteristics of Airyprime beams denote that they could have potential application prospects such as optical trapping.

Current, future and potential use of mobile and wearable technologies and social media data in the ABCD study to increase understanding of contributors to child health.

PubMed

Bagot, K S; Matthews, S A; Mason, M; Squeglia, Lindsay M; Fowler, J; Gray, K; Herting, M; May, A; Colrain, I; Godino, J; Tapert, S; Brown, S; Patrick, K

2018-08-01

Mobile and wearable technologies and novel methods of data collection are innovating health-related research. These technologies and methods allow for multi-system level capture of data across environmental, physiological, behavioral, and psychological domains. In the Adolescent Brain Cognitive Development (ABCD) Study, there is great potential for harnessing the acceptability, accessibility, and functionality of mobile and social technologies for in-vivo data capture to precisely measure factors, and interactions between factors, that contribute to childhood and adolescent neurodevelopment and psychosocial and health outcomes. Here we discuss advances in mobile and wearable technologies and methods of analysis of geospatial, ecologic, social network and behavioral data. Incorporating these technologies into the ABCD study will allow for interdisciplinary research on the effects of place, social interactions, environment, and substance use on health and developmental outcomes in children and adolescents. Copyright © 2018. Published by Elsevier Ltd.

ABCD syndrome is caused by a homozygous mutation in the EDNRB gene.

PubMed

Verheij, Joke B G M; Kunze, Jürgen; Osinga, Jan; van Essen, Anthonie J; Hofstra, Robert M W

2002-03-15

ABCD syndrome is an autosomal recessive syndrome characterized by albinism, black lock, cell migration disorder of the neurocytes of the gut (Hirschsprung disease [HSCR]), and deafness. This phenotype clearly overlaps with the features of the Shah-Waardenburg syndrome, comprising sensorineural deafness; hypopigmentation of skin, hair, and irides; and HSCR. Therefore, we screened DNA of the index patient of the ABCD syndrome family for mutations in the endothelin B receptor (EDNRB) gene, a gene known to be involved in Shah-Waardenburg syndrome. A homozygous nonsense mutation in exon 3 (R201X) of the EDNRB gene was found. We therefore suggest that ABCD syndrome is not a separate entity, but an expression of Shah-Waardenburg syndrome.

Phase-locking of combination-cylinder discharge CO2 laser

NASA Astrophysics Data System (ADS)

Xu, Yonggen

2014-05-01

A new type of laser resonator is presented to obtained good coherent beam and the parameters of the laser beam are calculated. The principle of phase-locking is described based on the injection-locking, the properties of the injected beam in the resonator are studied in detail. The output beam from output mirror is an annular laser beam with zero central intensity. An analytical expression for the annular laser beam through the ABCD optical system is derived. Typical numerical examples are calculated to confirm our analytical results. It is shown that the good coherent beam can be obtained through phase-locking, and the central intensity of annular beam through ABCD optical system will become maximum when the parameters of laser beam are selected reasonably.

High ABCD2 Scores and In-Hospital Interventions following Transient Ischemic Attack

PubMed Central

Cutting, Shawna; Regan, Elizabeth; Lee, Vivien H.; Prabhakaran, Shyam

2016-01-01

Background and Purpose Following transient ischemic attack (TIA), there is increased risk for ischemic stroke. The American Heart Association recommends admission of patients with ABCD2 scores ≥3 for observation, rapid performance of diagnostic tests, and potential acute intervention. We aimed to determine if there is a relationship between ABCD2 scores, in-hospital ischemic events, and in-hospital treatments after TIA admission. Methods We reviewed consecutive patients admitted between 2006 and 2011 following a TIA, defined as transient focal neurological symptoms attributed to a specific vascular distribution and lasting <24 h. Three interventions were prespecified: anticoagulation for atrial fibrillation, carotid or intracranial revascularization, and intravenous or intra-arterial reperfusion therapies. We compared rates of in-hospital recurrent TIA or ischemic stroke and the receipt of interventions among patients with low (<3) versus high (≥3) ABCD2 scores. Results Of 249 patients, 11 patients (4.4%) had recurrent TIAs or strokes during their stay (8 TIAs, 3 strokes). All 11 had ABCD2 scores ≥3, and no neurological events occurred in patients with lower scores (5.1 vs. 0%; p = 0.37). Twelve patients (4.8%) underwent revascularization for large artery stenosis, 16 (6.4%) were started on anticoagulants, and no patient received intravenous or intra-arterial reperfusion therapy. The ABCD2 score was not associated with anticoagulation (p = 0.59) or revascularization (p = 0.20). Conclusions Higher ABCD2 scores may predict early ischemic events after TIA but do not predict the need for intervention. Outpatient evaluation for those with scores <3 would potentially have delayed revascularization or anticoagulant treatment in nearly one-fifth of ‘low-risk’ patients. PMID:27721312

Identifying Barriers to Delivering the Awakening and Breathing Coordination, Delirium, and Early Exercise/Mobility Bundle to Minimize Adverse Outcomes for Mechanically Ventilated Patients: A Systematic Review.

PubMed

Costa, Deena Kelly; White, Matthew R; Ginier, Emily; Manojlovich, Milisa; Govindan, Sushant; Iwashyna, Theodore J; Sales, Anne E

2017-08-01

Improved outcomes are associated with the Awakening and Breathing Coordination, Delirium, and Early exercise/mobility bundle (ABCDE); however, implementation issues are common. As yet, no study has integrated the barriers to ABCDE to provide an overview of reasons for less successful efforts. The purpose of this review was to identify and catalog the barriers to ABCDE delivery based on a widely used implementation framework, and to provide a resource to guide clinicians in overcoming barriers to implementation. We searched MEDLINE via PubMed, CINAHL, and Scopus for original research articles from January 1, 2007, to August 31, 2016, that identified barriers to ABCDE implementation for adult patients in the ICU. Two reviewers independently reviewed studies, extracted barriers, and conducted thematic content analysis of the barriers, guided by the Consolidated Framework for Implementation Research. Discrepancies were discussed, and consensus was achieved. Our electronic search yielded 1,908 articles. After applying our inclusion/exclusion criteria, we included 49 studies. We conducted thematic content analysis of the 107 barriers and identified four classes of ABCDE barriers: (1) patient-related (ie, patient instability and safety concerns); (2) clinician-related (ie, lack of knowledge, staff safety concerns); (3) protocol-related (ie, unclear protocol criteria, cumbersome protocols to use); and, not previously identified in past reviews, (4) ICU contextual barriers (ie, interprofessional team care coordination). We provide the first, to our knowledge, systematic differential diagnosis of barriers to ABCDE delivery, moving beyond the conventional focus on patient-level factors. Our analysis offers a differential diagnosis checklist for clinicians planning ABCDE implementation to improve patient care and outcomes. Copyright © 2017 American College of Chest Physicians. All rights reserved.

ICU team composition and its association with ABCDE implementation in a quality collaborative.

PubMed

Costa, Deena Kelly; Valley, Thomas S; Miller, Melissa A; Manojlovich, Milisa; Watson, Sam R; McLellan, Phyllis; Pope, Corine; Hyzy, Robert C; Iwashyna, Theodore J

2018-04-01

Awakening, Breathing Coordination, Delirium, and Early Mobility bundle (ABCDE) should involve an interprofessional team, yet no studies describe what team composition supports implementation. We administered a survey at MHA Keystone Center ICU 2015 workshop. We measured team composition by the frequency of nurse, respiratory therapist, physician, physical therapist, nurse practitioner/physician assistant or nursing assistant involvement in 1) spontaneous awakening trials (SATs), 2) spontaneous breathing trials, 3) delirium and 4) early mobility. We assessed ABCDE implementation using a 5-point Likert ("routine part of every patient's care" - "no plans to implement"). We used ordinal logistic regression to examine team composition and ABCDE implementation, adjusting for confounders and clustering. From 293 surveys (75% response rate), we found that frequent nurse [OR 6.1 (1.1-34.9)] and physician involvement [OR 4.2 (1.3-13.4)] in SATs, nurse [OR 4.7 (1.6-13.4)] and nursing assistant's involvement [OR 3.9 (1.2-13.5)] in delirium and nurse [OR 2.8 (1.2-6.7)], physician [OR (3.6 (1.2-10.3)], and nursing assistants' involvement [OR 2.3 (1.1-4.8)] in early mobility were significantly associated with higher odds of routine ABCDE implementation. ABCDE implementation was associated with frequent involvement of team members, suggesting a need for role articulation and coordination. Copyright © 2017 Elsevier Inc. All rights reserved.

Air-borne contact dermatitis caused exclusively by xanthium strumarium.

PubMed

Pasricha, J S; Verma, K K; D'Souza, P

1995-01-01

Most cases having air-borne contact dermatitis (ABCD) in India are considered to be caused by Parthenium hysterophorus. In some cases however, other plants have also been noticed to give positive patch test reactions. We are reporting two cases presenting as ABCD who showed positive patch tests with Xanthium strumarium while the patch tests with Parthenium hysterophorus were negative. It is therefore necessary to realise that every case of ABCD is not caused by Parthenium, and patch testing with Parthenium alone can lead to serious mistakes.

Conversion of chlorobiphenyls into phenylhexadienoates and benzoates by the enzymes of the upper pathway for polychlorobiphenyl degradation encoded by the bph locus of Pseudomonas sp. strain LB400.

PubMed Central

Seeger, M; Timmis, K N; Hofer, B

1995-01-01

Metabolism of 21 chlorobiphenyls by the enzymes of the upper biphenyl catabolic pathway encoded by the bph locus of Pseudomonas sp. strain LB400 was investigated by using recombinant strains harboring gene cassettes containing bphABC or bphABCD. The enzymes of the upper pathway were generally able to metabolize mono- and dichlorinated biphenyls but only partially transform most trichlorinated congeners investigated: 14 of 15 mono- and dichlorinated and 2 of 6 trichlorinated congeners were converted into benzoates. All mono- and at least 8 of 12 dichlorinated congeners were attacked by the bphA-encoded biphenyl dioxygenase virtually exclusively at ortho and meta carbons. This enzyme exhibited a high degree of selectivity for the aromatic ring to be attacked, with the order of ring preference being non- > ortho- > meta- > para-substituted for mono- and dichlorinated congeners. The influence of the chlorine substitution pattern of the metabolized ring on benzoate formation resembled its influence on the reactivity of initial dioxygenation, suggesting that the rate of benzoate formation may frequently be determined by the rate of initial attack. The absorption spectra of phenylhexadienoates formed correlated with the presence or absence of a chlorine substituent at an ortho position. PMID:7618878

Triaging TIA/minor stroke patients using the ABCD2 score does not predict those with significant carotid disease.

PubMed

Walker, J; Isherwood, J; Eveson, D; Naylor, A R

2012-05-01

'Rapid Access' TIA Clinics use the ABCD(2) score to triage patients as it is not possible to see everyone with a suspected TIA <24 h. Those scoring 0-3 are seen within seven days, while patients scoring 4-7 are seen as soon as possible (preferably <24 h). It was hypothesized that patients scoring 4-7 would have a higher yield of significant carotid disease. Prospective study of correlation between Family Doctor (FD) or Emergency Department (ED) ABCD(2) score and specialist consultant Stroke Physician measured ABCD(2) score and prevalence of ≥50% ipsilateral carotid stenosis or occlusion in patients presenting with 'any territory' TIA/minor stroke or 'carotid territory' TIA/minor stroke. Between 1.10.2008 and 31.04.2011, 2452 patients were referred to the Leicester Rapid Access TIA Service. After Stroke Physician review, 1273 (52%) were thought to have suffered a minor stroke/TIA. Of these, both FD/ED referrer and Specialist Stroke Consultant ABCD(2) scores and carotid Duplex ultrasound studies were available for 843 (66%). The yield for identifying a ≥50% stenosis or carotid occlusion was 109/843 (12.9%) in patients with 'any territory' TIA/minor stroke and 101/740 (13.6%) in those with a clinical diagnosis of 'carotid territory' TIA/minor stroke. There was no association between ABCD(2) score and the likelihood of encountering significant carotid disease and analyses of the area under the receiver operating characteristic curve (AUC) for FD/ED referrer and stroke specialist ABCD(2) scores showed no prediction of carotid stenosis (FD/ED: AUC 0.50 (95%CI 0.44-0.55, p = 0.9), Specialist: AUC 0.51 (95%CI 0.45-0.57, p = 0.78). The ABCD(2) score was unable to identify TIA/minor stroke patients with a higher prevalence of clinically important ipsilateral carotid disease. Copyright © 2012 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

Demographics and Psychological Factors Associated with Adiposity in Nurses

PubMed Central

Chinchilla-Ochoa, Daniela; Morales-Hernández, Rosa

2018-01-01

Adiposity-based chronic disease (ABCD), overweight-Ow- or obesity-Ob-) in health personnel is as frequent as in the general population, even though they understand well the importance of maintaining a healthy weight. Thus, it is highly likely that certain demographic and psychological conditions, independently of knowledge, are contributing to develop ABCD. The aim of this study was to examine the association between these factors and ABCD in nurses. Data were collected from a cross-sectional study conducted in a tertiary level institute in Mexico City from 2012 to 2013. All the nurses of the institute of any age, shift, service area and seniority were invited to participate and 55% (265) accepted. We found that ABCD was present in 79.6%, and low self-esteem and emotional distress in 26% and 10%, respectively. Working in the night shift (p = 0.031), labor seniority ≥15 years (p = 0.006), having 1 or more children (p = 0.021) and sessions of physical activity <30 min (p = 0.03) were associated with ABCD. Low self-esteem (OR = 2, 95% CI 1.150–3.07, p = 0.023) and emotional distress (OR = 4, 95% CI 1.472–13.078, p = 0.012) were associated with unhealthy lifestyle (less of 3 days per week and/or less of 30 min per session of physical activity and poor dietary habits). Therefore, strategies to prevent and treat ABCD must consider each context among nurses and psychological disorders need be identified to avoid an unhealthy lifestyle. PMID:29601502

The FlxABCD-HdrABC proteins correspond to a novel NADH dehydrogenase/heterodisulfide reductase widespread in anaerobic bacteria and involved in ethanol metabolism in Desulfovibrio vulgaris Hildenborough.

PubMed

Ramos, Ana Raquel; Grein, Fabian; Oliveira, Gonçalo P; Venceslau, Sofia S; Keller, Kimberly L; Wall, Judy D; Pereira, Inês A C

2015-07-01

Flavin-based electron bifurcation (FBEB) is an important mechanism for the energy metabolism of anaerobes. A new family of NADH dehydrogenases, the flavin oxidoreductase (FlxABCD, previously called FloxABCD), was proposed to perform FBEB in sulphate-reducing organisms coupled with heterodisulfide reductase (HdrABC). We found that the hdrABC-flxABCD gene cluster is widespread among anaerobic bacteria, pointing to a general and important role in their bioenergetics. In this work, we studied FlxABCD of Desulfovibrio vulgaris Hildenborough. The hdr-flx genes are part of the same transcriptional unit and are increased in transcription during growth in ethanol-sulfate, and to a less extent during pyruvate fermentation. Two mutant strains were generated: one where expression of the hdr-flx genes was interrupted and another lacking the flxA gene. Both strains were unable to grow with ethanol-sulfate, whereas growth was restored in a flxA-complemented strain. The mutant strains also produced very reduced amounts of ethanol compared with the wild type during pyruvate fermentation. Our results show that in D. vulgaris, the FlxABCD-HdrABC proteins are essential for NADH oxidation during growth on ethanol, probably involving a FBEB mechanism that leads to reduction of ferredoxin and the small protein DsrC, while in fermentation they operate in reverse, reducing NAD(+) for ethanol production. © 2014 Society for Applied Microbiology and John Wiley & Sons Ltd.

Application of the new GOLD COPD staging system to a US primary care cohort, with comparison to physician and patient impressions of severity.

PubMed

Mapel, Douglas W; Dalal, Anand A; Johnson, Phaedra T; Becker, Laura K; Hunter, Alyssa Goolsby

2015-01-01

In 2011, the traditional Global Initiative for Chronic Obstructive Lung Disease (GOLD) COPD spirometry-based severity classification system was revised to also include exacerbation history and COPD Assessment Test (CAT) and modified Medical Research Council Dyspnea Scale (mMRC) scores. This study examined how COPD patients treated in primary care are reclassified by the new GOLD system compared to the traditional system, and each system's level of agreement with patient's or physician's severity assessments. In this US multicenter cross-sectional study, COPD patients were recruited by 83 primary care practitioners (PCPs) to complete spirometry testing and a survey. Patients were classified by the traditional spirometry-based system (stages 1-4) and under the new system (grades A, B, C, D) using spirometry, exacerbation history, mMRC, and/or CAT results. Concordance between physician and patient-reported severity, spirometry stage, and ABCD grade based on either mMRC or CAT scores was examined. Data from 445 patients with spirometry-confirmed COPD were used. As compared to the traditional system, the GOLD mMRC system reclassifies 47% of patients, and GOLD CAT system reclassifies 41%, but the distributions are very different. The GOLD mMRC system resulted in relatively equal distributions by ABCD grade (33%, 22%, 19%, 26%, respectively), but the GOLD CAT system put most into either B or D groups (9%, 45%, 4%, and 42%). The addition of exacerbation history reclassified only 19 additional patients. Agreement between PCPs' severity rating or their patients' self-assessment and the new ABCD grade was very poor (κ=0.17 or less). As compared to the traditional system, the GOLD 2011 multidimensional system reclassified nearly half of patients, but how they were reclassified varied greatly by whether the mMRC or CAT questionnaire was chosen. Either way, the new system had little correlation with the PCPs or their patients' impressions about the COPD severity.

Acquired Brachial Cutaneous Dyschromatosis in a Middle Aged Male

PubMed Central

Choi, Min Jung; Byun, Ji Yeon; Choi, Hae Young

2018-01-01

Acquired brachial cutaneous dyschromatosis (ABCD) is an acquired disorder of pigmentary change that presents as chronic, asymptomatic, geographic-shaped, gray-brown patches, consisting of mixed hyper and hypopigmented macules on the dorsal aspect of the forearms. We report a case of a 40-year-old male who presented with asymptomatic, multiple brown-colored macules on the outer aspects of both arms. He had no history of hypertension and had never taken angiotensin converting enzyme inhibitors. He also denied chronic sun exposure history. Histologic examination demonstrated epidermal atrophy, increased basal layer pigmentation, and several telangiectatic vessels in the upper dermis. Solar elastosis was not remarkable. The patient's clinical and histopathologic features were consistent with a diagnosis of ABCD. Poikiloderma of Civatte, melasma, acquired bilateral telangiectatic macules and other pigmentary disorders should be considered in the differential diagnosis of ABCD. Herein, we report a case of ABCD in a middle-aged male without hypertension and medication. PMID:29853750

Application of the new GOLD COPD staging system to a US primary care cohort, with comparison to physician and patient impressions of severity

PubMed Central

Mapel, Douglas W; Dalal, Anand A; Johnson, Phaedra T; Becker, Laura K; Hunter, Alyssa Goolsby

2015-01-01

Background In 2011, the traditional Global Initiative for Chronic Obstructive Lung Disease (GOLD) COPD spirometry-based severity classification system was revised to also include exacerbation history and COPD Assessment Test (CAT) and modified Medical Research Council Dyspnea Scale (mMRC) scores. This study examined how COPD patients treated in primary care are reclassified by the new GOLD system compared to the traditional system, and each system’s level of agreement with patient’s or physician’s severity assessments. Methods In this US multicenter cross-sectional study, COPD patients were recruited by 83 primary care practitioners (PCPs) to complete spirometry testing and a survey. Patients were classified by the traditional spirometry-based system (stages 1–4) and under the new system (grades A, B, C, D) using spirometry, exacerbation history, mMRC, and/or CAT results. Concordance between physician and patient-reported severity, spirometry stage, and ABCD grade based on either mMRC or CAT scores was examined. Results Data from 445 patients with spirometry-confirmed COPD were used. As compared to the traditional system, the GOLD mMRC system reclassifies 47% of patients, and GOLD CAT system reclassifies 41%, but the distributions are very different. The GOLD mMRC system resulted in relatively equal distributions by ABCD grade (33%, 22%, 19%, 26%, respectively), but the GOLD CAT system put most into either B or D groups (9%, 45%, 4%, and 42%). The addition of exacerbation history reclassified only 19 additional patients. Agreement between PCPs’ severity rating or their patients’ self-assessment and the new ABCD grade was very poor (κ=0.17 or less). Conclusion As compared to the traditional system, the GOLD 2011 multidimensional system reclassified nearly half of patients, but how they were reclassified varied greatly by whether the mMRC or CAT questionnaire was chosen. Either way, the new system had little correlation with the PCPs or their patients’ impressions about the COPD severity. PMID:26251587

Propagation of partially coherent Lorentz and Lorentz-Gauss beams through a paraxial ABCD optical system in a turbulent atmosphere

NASA Astrophysics Data System (ADS)

Zhao, Chengliang; Cai, Yangjian

2011-05-01

Based on the generalized Huygens-Fresnel integral, propagation of partially coherent Lorentz and Lorentz-Gauss beams through a paraxial ABCD optical system in a turbulent atmosphere was investigated. Analytical propagation formulae were derived for the cross-spectral densities of partially coherent Lorentz and Lorentz-Gauss beams. As an application example, the focusing properties of partially coherent Gaussian, Lorentz and Lorentz-Gauss beams in a turbulent atmosphere and in free space were studied numerically and comparatively. It is found that the focusing properties of such beams are closely related to the initial coherence length and the structure constant of turbulence. By choosing a suitable initial coherence length, a partially coherent Lorentz beam can be focused more tightly than a Gaussian or Lorentz-Gauss beam in free space or in a turbulent atmosphere with small structure constant at the geometrical focal plane.

From serological to computer cross-matching in nine hospitals.

PubMed

Georgsen, J; Kristensen, T

1998-01-01

In 1991 it was decided to reorganise the transfusion service of the County of Funen. The aims were to standardise and improve the quality of blood components, laboratory procedures and the transfusion service and to reduce the number of outdated blood units. Part of the efficiency gains was reinvested in a dedicated computer system making it possible--among other things--to change the cross-match procedures from serological to computer cross-matching according to the ABCD-concept. This communication describes how this transition was performed in terms of laboratory techniques, education of personnel as well as implementation of the computer system and indicates the results obtained. The Funen Transfusion Service has by now performed more than 100.000 red cell transfusions based on ABCD-cross-matching and has not encountered any problems. Major results are the significant reductions of cross-match procedures, blood grouping as well as the number of outdated blood components.

Clinical- and imaging-based prediction of stroke risk after transient ischemic attack: the CIP model.

PubMed

Ay, Hakan; Arsava, E Murat; Johnston, S Claiborne; Vangel, Mark; Schwamm, Lee H; Furie, Karen L; Koroshetz, Walter J; Sorensen, A Gregory

2009-01-01

Predictive instruments based on clinical features for early stroke risk after transient ischemic attack suffer from limited specificity. We sought to combine imaging and clinical features to improve predictions for 7-day stroke risk after transient ischemic attack. We studied 601 consecutive patients with transient ischemic attack who had MRI within 24 hours of symptom onset. A logistic regression model was developed using stroke within 7 days as the response criterion and diffusion-weighted imaging findings and dichotomized ABCD(2) score (ABCD(2) >/=4) as covariates. Subsequent stroke occurred in 25 patients (5.2%). Dichotomized ABCD(2) score and acute infarct on diffusion-weighted imaging were each independent predictors of stroke risk. The 7-day risk was 0.0% with no predictor, 2.0% with ABCD(2) score >/=4 alone, 4.9% with acute infarct on diffusion-weighted imaging alone, and 14.9% with both predictors (an automated calculator is available at http://cip.martinos.org). Adding imaging increased the area under the receiver operating characteristic curve from 0.66 (95% CI, 0.57 to 0.76) using the ABCD(2) score to 0.81 (95% CI, 0.74 to 0.88; P=0.003). The sensitivity of 80% on the receiver operating characteristic curve corresponded to a specificity of 73% for the CIP model and 47% for the ABCD(2) score. Combining acute imaging findings with clinical transient ischemic attack features causes a dramatic boost in the accuracy of predictions with clinical features alone for early risk of stroke after transient ischemic attack. If validated in relevant clinical settings, risk stratification by the CIP model may assist in early implementation of therapeutic measures and effective use of hospital resources.

A mathematical analysis of the ABCD criteria for diagnosing malignant melanoma

NASA Astrophysics Data System (ADS)

Lee, Hyunju; Kwon, Kiwoon

2017-03-01

The medical community currently employs the ABCD (asymmetry, border irregularity, color variegation, and diameter of the lesion) criteria in the early diagnosis of a malignant melanoma. Although many image segmentation and classification methods are used to analyze the ABCD criteria, it is rare to see a study containing mathematical justification of the parameters that are used to quantify the ABCD criteria. In this paper, we suggest new parameters to assess asymmetry, border irregularity, and color variegation, and explain the mathematical meaning of the parameters. The suggested parameters are then tested with 24 skin samples. The parameters suggested for the 24 skin samples are displayed in three-dimensional coordinates and are compared to those presented in other studies (Ercal et al 1994 IEEE Trans. Biomed. Eng. 41 837-45, Cheerla and Frazier 2014 Int. J. Innovative Res. Sci., Eng. Technol. 3 9164-83) in terms of Pearson correlation coefficient and classification accuracy in determining the malignancy of the lesions.

Closed-form solution for the Wigner phase-space distribution function for diffuse reflection and small-angle scattering in a random medium.

PubMed

Yura, H T; Thrane, L; Andersen, P E

2000-12-01

Within the paraxial approximation, a closed-form solution for the Wigner phase-space distribution function is derived for diffuse reflection and small-angle scattering in a random medium. This solution is based on the extended Huygens-Fresnel principle for the optical field, which is widely used in studies of wave propagation through random media. The results are general in that they apply to both an arbitrary small-angle volume scattering function, and arbitrary (real) ABCD optical systems. Furthermore, they are valid in both the single- and multiple-scattering regimes. Some general features of the Wigner phase-space distribution function are discussed, and analytic results are obtained for various types of scattering functions in the asymptotic limit s > 1, where s is the optical depth. In particular, explicit results are presented for optical coherence tomography (OCT) systems. On this basis, a novel way of creating OCT images based on measurements of the momentum width of the Wigner phase-space distribution is suggested, and the advantage over conventional OCT images is discussed. Because all previous published studies regarding the Wigner function are carried out in the transmission geometry, it is important to note that the extended Huygens-Fresnel principle and the ABCD matrix formalism may be used successfully to describe this geometry (within the paraxial approximation). Therefore for completeness we present in an appendix the general closed-form solution for the Wigner phase-space distribution function in ABCD paraxial optical systems for direct propagation through random media, and in a second appendix absorption effects are included.

Translational Repression of NhaR, a Novel Pathway for Multi-Tier Regulation of Biofilm Circuitry by CsrA

PubMed Central

Pannuri, Archana; Yakhnin, Helen; Vakulskas, Christopher A.; Edwards, Adrianne N.; Babitzke, Paul

2012-01-01

The RNA binding protein CsrA (RsmA) represses biofilm formation in several proteobacterial species. In Escherichia coli, it represses the production of the polysaccharide adhesin poly-β-1,6-N-acetyl-d-glucosamine (PGA) by binding to the pgaABCD mRNA leader, inhibiting pgaA translation, and destabilizing this transcript. In addition, CsrA represses genes responsible for the synthesis of cyclic di-GMP, an activator of PGA production. Here we determined that CsrA also represses NhaR, a LysR-type transcriptional regulator which responds to elevated [Na+] and alkaline pH and activates the transcription of the pgaABCD operon. Gel shift studies revealed that CsrA binds at two sites in the 5′ untranslated segment of nhaR, one of which overlaps the Shine-Dalgarno sequence. An epitope-tagged NhaR protein, expressed from the nhaR chromosomal locus, and an nhaR posttranscriptional reporter fusion (PlacUV5-nhaR′-′lacZ) both showed robust repression by CsrA. Northern blotting revealed a complex transcription pattern for the nhaAR locus. Nevertheless, CsrA did not repress nhaR mRNA levels. Toeprinting assays showed that CsrA competes effectively with the ribosome for binding to the translation initiation region of nhaR. Together, these findings indicate that CsrA blocks nhaR translation. Epistasis studies with a pgaA-lacZ transcriptional fusion confirmed a model in which CsrA indirectly represses pgaABCD transcription via NhaR. We conclude that CsrA regulates the horizontally acquired pgaABCD operon and PGA biosynthesis at multiple levels. Furthermore, nhaR repression exemplifies an expanding role for CsrA as a global regulator of stress response systems. PMID:22037401

A description of the ABCD organizational structure and communication framework.

PubMed

Auchter, Allison M; Hernandez Mejia, Margie; Heyser, Charles J; Shilling, Paul D; Jernigan, Terry L; Brown, Sandra A; Tapert, Susan F; Dowling, Gayathri J

2018-04-16

The Adolescent Brain Cognitive Development (ABCD) study is designed to be the largest study of brain development and child health in the United States, performing comprehensive assessments of 11,500 children repeatedly for 10 years. An endeavor of this magnitude requires an organized framework of governance and communication that promotes collaborative decision-making and dissemination of information. The ABCD consortium structure, built upon the Matrix Management approach of organizational theory, facilitates the integration of input from all institutions, numerous internal workgroups and committees, federal partners, and external advisory groups to make use of a broad range of expertise to ensure the study's success. Copyright © 2018 Elsevier Ltd. All rights reserved.

Promoting Protective Factors for Young Adolescents: ABCD Parenting Young Adolescents Program Randomized Controlled Trial

ERIC Educational Resources Information Center

Burke, Kylie; Brennan, Leah; Cann, Warren

2012-01-01

This study examined the efficacy of a program for parents of young adolescents combining behavioral family intervention with acceptance-based strategies. 180 parents were randomly allocated to a 6-session group ABCD Parenting Young Adolescent Program or wait-list condition. Completer analysis indicated parents in the intervention reported…

East Indian Families Raising ABCD Adolescents: Cultural and Generational Challenges

ERIC Educational Resources Information Center

Poulsen, Shruti S.

2009-01-01

Immigration is a process fraught with both challenges and opportunities for families. In particular, East Indian families with U.S.-born adolescents experience the challenges of bridging cultures across generational divides; they are perceived by others as confused, identity less, and conflicted or as American-Born, Confused Desis (ABCDs). This…

Comparison of dermatoscopic diagnostic algorithms based on calculation: The ABCD rule of dermatoscopy, the seven-point checklist, the three-point checklist and the CASH algorithm in dermatoscopic evaluation of melanocytic lesions.

PubMed

Unlu, Ezgi; Akay, Bengu N; Erdem, Cengizhan

2014-07-01

Dermatoscopic analysis of melanocytic lesions using the CASH algorithm has rarely been described in the literature. The purpose of this study was to compare the sensitivity, specificity, and diagnostic accuracy rates of the ABCD rule of dermatoscopy, the seven-point checklist, the three-point checklist, and the CASH algorithm in the diagnosis and dermatoscopic evaluation of melanocytic lesions on the hairy skin. One hundred and fifteen melanocytic lesions of 115 patients were examined retrospectively using dermatoscopic images and compared with the histopathologic diagnosis. Four dermatoscopic algorithms were carried out for all lesions. The ABCD rule of dermatoscopy showed sensitivity of 91.6%, specificity of 60.4%, and diagnostic accuracy of 66.9%. The seven-point checklist showed sensitivity, specificity, and diagnostic accuracy of 87.5, 65.9, and 70.4%, respectively; the three-point checklist 79.1, 62.6, 66%; and the CASH algorithm 91.6, 64.8, and 70.4%, respectively. To our knowledge, this is the first study that compares the sensitivity, specificity and diagnostic accuracy of the ABCD rule of dermatoscopy, the three-point checklist, the seven-point checklist, and the CASH algorithm for the diagnosis of melanocytic lesions on the hairy skin. In our study, the ABCD rule of dermatoscopy and the CASH algorithm showed the highest sensitivity for the diagnosis of melanoma. © 2014 Japanese Dermatological Association.

Improving access for Medicaid-insured children: focus on front-office personnel.

PubMed

Lam, M; Riedy, C A; Milgrom, P

1999-03-01

Access to dental services for low-income children is limited. Front-office personnel play a role regarding dentists' participation in the Medicaid program. Subjects (N = 24) represented general dental offices in Spokane County, Wash., and included participants and nonparticipants in the Access to Baby and Child Dentistry, or ABCD, program, a dental society/community program aimed at expanding dental services provided to Medicaid-insured children. The authors stratified the participants according to the number of claims their practices submitted to Medicaid for ABCD children: non-ABCD, low-ABCD and high-ABCD. Five two-hour focus group sessions were conducted to determine participants' beliefs about, attitudes toward and experiences in serving this population. The authors' data analysis consisted of a comprehensive content review of participants' responses from transcripted audiotapes. They synthesized frequently mentioned concepts and ideas into relevant themes. The major factors affecting practices' participation in Medicaid were office policy on seeing Medicaid-insured patients; staff members' personal connection to Medicaid-insured patients; staff members' attitudes about Medicaid-insured patients; and staff members' perceptions of Medicaid-insured patients' barriers to care. The data suggest that factors affecting dentists' participation in the Medicaid program are more complex than the often-stated dissatisfactions with low reimbursement fees and hassles with paperwork. Efforts to increase dentist participation in serving Medicaid-insured patients will continue to be relatively ineffective until many of the concerns raised by this study's subjects are better understood and addressed.

Oxidoreductases that Act as Conditional Virulence Suppressors in Salmonella enterica Serovar Typhimurium

PubMed Central

Anwar, Naeem; Sem, Xiao Hui; Rhen, Mikael

2013-01-01

In Salmonella enterica serovar Typhimurium, oxidoreductases of the thioredoxin superfamily contribute to bacterial invasiveness, intracellular replication and to the virulence in BALB/c mice as well as in the soil nematode Caenorhabditis elegans. The scsABCD gene cluster, present in many but not all enteric bacteria, codes for four putative oxidoreductases of the thioredoxin superfamily. Here we have analyzed the potential role of the scs genes in oxidative stress tolerance and virulence in S. Typhimurium. An scsABCD deletion mutant showed moderate sensitization to the redox-active transition metal ion copper and increased protein carbonylation upon exposure to hydrogen peroxide. Still, the scsABCD mutant was not significantly affected for invasiveness or intracellular replication in respectively cultured epithelial or macrophage-like cells. However, we noted a significant copper chloride sensitivity of SPI1 T3SS mediated invasiveness that strongly depended on the presence of the scs genes. The scsABCD deletion mutant was not attenuated in animal infection models. In contrast, the mutant showed a moderate increase in its competitive index upon intraperitoneal challenge and enhanced invasiveness in small intestinal ileal loops of BALB/c mice. Moreover, deletion of the scsABCD genes restored the invasiveness of a trxA mutant in epithelial cells and its virulence in C. elegans. Our findings thus demonstrate that the scs gene cluster conditionally affects virulence and underscore the complex interactions between oxidoreductases of the thioredoxin superfamily in maintaining host adaptation of S. Typhimurium. PMID:23750221

Hollow vortex Gaussian beams

NASA Astrophysics Data System (ADS)

Zhou, GuoQuan; Cai, YangJian; Dai, ChaoQing

2013-05-01

A kind of hollow vortex Gaussian beam is introduced. Based on the Collins integral, an analytical propagation formula of a hollow vortex Gaussian beam through a paraxial ABCD optical system is derived. Due to the special distribution of the optical field, which is caused by the initial vortex phase, the dark region of a hollow vortex Gaussian beam will not disappear upon propagation. The analytical expressions for the beam propagation factor, the kurtosis parameter, and the orbital angular momentum density of a hollow vortex Gaussian beam passing through a paraxial ABCD optical system are also derived, respectively. The beam propagation factor is determined by the beam order and the topological charge. The kurtosis parameter and the orbital angular momentum density depend on beam order n, topological charge m, parameter γ, and transfer matrix elements A and D. As a numerical example, the propagation properties of a hollow vortex Gaussian beam in free space are demonstrated. The hollow vortex Gaussian beam has eminent propagation stability and has crucial application prospects in optical micromanipulation.

Design, synthesis, and biological evaluation of the first podophyllotoxin analogues as potential vascular-disrupting agents.

PubMed

Labruère, Raphaël; Gautier, Benoît; Testud, Marlène; Seguin, Johanne; Lenoir, Christine; Desbène-Finck, Stéphanie; Helissey, Philippe; Garbay, Christiane; Chabot, Guy G; Vidal, Michel; Giorgi-Renault, Sylviane

2010-12-03

We designed and synthesized two novel series of azapodophyllotoxin analogues as potential antivascular agents. A linker was inserted between the trimethoxyphenyl ring E and the tetracyclic ABCD moiety of the 4-aza-1,2-didehydropodophyllotoxins. In the first series, the linker enables free rotation between the two moieties; in the second series, conformational restriction of the E nucleus was considered. We have identified several new compounds with inhibitory activity toward tubulin polymerization similar to that of CA-4 and colchicine, while displaying low cytotoxic activity against normal and/or cancer cells. An aminologue and a methylenic analogue were shown to disrupt endothelial cell cords on Matrigel at subtoxic concentrations, and an original assay of drug washout allowed us to demonstrate the rapid reversibility of this effect. These two new analogues are promising leads for the development of vascular-disrupting agents in the podophyllotoxin series.

Analysis of the linguistic profile in down syndrome using the arizona battery for communication disorders of dementia - a pilot study.

PubMed

Carvalho, Cláudia Lopes; Belan, Ariella Fornachari Ribeiro; Castro, Leila Regina de; Radanovic, Márcia

2018-03-12

To characterize the linguistic profile of adults and elderly with Down Syndrome (DS) using the Arizona Battery for Communication Disorders of Dementia (ABCD). Thirty adult individuals with DS were evaluated through the MoCA cognitive battery, four functional scales (Pfeffer, Lawton-IADL, Katz-IADL and IQCODE) and the ABCD battery, which evaluates Mental State, Episodic Memory, Linguistic Expression, Linguistic Comprehension and Visuospatial Construction. The scores obtained by the individuals in the ABCD were correlated to those obtained on the Lawton-IADL scale. Individuals with DS had significantly lower performance than cognitively normal adults and elderly as described in Brazilian studies. Due to the lack of similar studies in our country, we compared our results to those of elderly with Alzheimer's Disease (AD), verifying that the performance of the DS population is similar to that of AD patients, although the former presented better scores on episodic immediate memory tests. There was a significant positive correlation between the scores obtained in the Lawton-IADL and those on the constructs Mental State, Episodic Memory, Linguistic Comprehension and Total ABCD. The ABCD battery is a useful tool in the evaluation of adults and elderly with DS and the performance of individuals in this battery correlates with indices of functionality. This is a pioneer study in Brazil, and it points to the need for a better characterization of the linguistic abilities of individuals with DS, in order to allow the elaboration of strategies that stimulate their communicative abilities as to promote greater social insertion for this population.

On the Green's function of the partially diffusion-controlled reversible ABCD reaction for radiation chemistry codes

NASA Astrophysics Data System (ADS)

Plante, Ianik; Devroye, Luc

2015-09-01

Several computer codes simulating chemical reactions in particles systems are based on the Green's functions of the diffusion equation (GFDE). Indeed, many types of chemical systems have been simulated using the exact GFDE, which has also become the gold standard for validating other theoretical models. In this work, a simulation algorithm is presented to sample the interparticle distance for partially diffusion-controlled reversible ABCD reaction. This algorithm is considered exact for 2-particles systems, is faster than conventional look-up tables and uses only a few kilobytes of memory. The simulation results obtained with this method are compared with those obtained with the independent reaction times (IRT) method. This work is part of our effort in developing models to understand the role of chemical reactions in the radiation effects on cells and tissues and may eventually be included in event-based models of space radiation risks. However, as many reactions are of this type in biological systems, this algorithm might play a pivotal role in future simulation programs not only in radiation chemistry, but also in the simulation of biochemical networks in time and space as well.

Effectiveness and Safety of the Awakening and Breathing Coordination, Delirium Monitoring/Management, and Early Exercise/Mobility (ABCDE) Bundle

PubMed Central

Balas, Michele C.; Vasilevskis, Eduard E.; Olsen, Keith M.; Schmid, Kendra K.; Shostrom, Valerie; Cohen, Marlene Z.; Peitz, Gregory; Gannon, David E.; Sisson, Joseph; Sullivan, James; Stothert, Joseph C.; Lazure, Julie; Nuss, Suzanne L.; Jawa, Randeep S.; Freihaut, Frank; Ely, E. Wesley; Burke, William J.

2014-01-01

Objective The debilitating and persistent effects of intensive care unit (ICU)-acquired delirium and weakness warrant testing of prevention strategies. The purpose of this study was to evaluate the effectiveness and safety of implementing the Awakening and Breathing Coordination, Delirium monitoring/management, and Early exercise/mobility (ABCDE) bundle into everyday practice. Design Eighteen-month, prospective, cohort, before-after study conducted between November 2010 and May 2012. Setting Five adult ICUs, one step-down unit, and one oncology/hematology special care unit located in a 624-bed tertiary medical center. Patients Two hundred ninety-six patients (146 pre- and 150 post-bundle implementation), age ≥ 19 years, managed by the institutions’ medical or surgical critical care service. Interventions ABCDE bundle. Measurements For mechanically ventilated patients (n = 187), we examined the association between bundle implementation and ventilator-free days. For all patients, we used regression models to quantify the relationship between ABCDE bundle implementation and the prevalence/duration of delirium and coma, early mobilization, mortality, time to discharge, and change in residence. Safety outcomes and bundle adherence were monitored. Main Results Patients in the post-implementation period spent three more days breathing without mechanical assistance than did those in the pre-implementation period (median [IQR], 24 [7 to 26] vs. 21 [0 to 25]; p = 0.04). After adjusting for age, sex, severity of illness, comorbidity, and mechanical ventilation status, patients managed with the ABCDE bundle experienced a near halving of the odds of delirium (odds ratio [OR], 0.55; 95% confidence interval [CI], 0.33–0.93; p = 0.03) and increased odds of mobilizing out of bed at least once during an ICU stay (OR, 2.11; 95% CI, 1.29–3.45; p = 0.003). No significant differences were noted in self-extubation or reintubation rates. Conclusions Critically ill patients managed with the ABCDE bundle spent three more days breathing without assistance, experienced less delirium, and were more likely to be mobilized during their ICU stay than patients treated with usual care. PMID:24394627

Indigenous health: effective and sustainable health services through continuous quality improvement.

PubMed

Bailie, Ross S; Si, Damin; O'Donoghue, Lyn; Dowden, Michelle

2007-05-21

The Australian government's Healthy for Life program is supporting capacity development in Indigenous primary care using continuous quality improvement (CQI) techniques. An important influence on the Healthy for Life program has been the ABCD research project. The key features contributing to the success of the project are described. The ABCD research project: uses a CQI approach, with an ongoing cycle of gathering data on how well organisational systems are functioning, and developing and then implementing improvements; is guided by widely accepted principles of community-based research, which emphasise participation; and adheres to the principles and values of Indigenous health research and service delivery. The potential for improving health outcomes in Aboriginal and Torres Strait Islander communities using a CQI approach should be strengthened by clear clinical and managerial leadership, supporting service organisations at the community level, and applying participatory-action principles.

Defense on the Move: Ant-Based Cyber Defense

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fink, Glenn A.; Haack, Jereme N.; McKinnon, Archibald D.

Many common cyber defenses (like firewalls and IDS) are as static as trench warfare allowing the attacker freedom to probe them at will. The concept of Moving Target Defense (MTD) adds dynamism to the defender side, but puts the systems to be defended themselves in motion, potentially at great cost to the defender. An alternative approach is a mobile resilient defense that removes attackers’ ability to rely on prior experience without requiring motion in the protected infrastructure itself. The defensive technology absorbs most of the cost of motion, is resilient to attack, and is unpredictable to attackers. The Ant-Based Cybermore » Defense (ABCD) is a mobile resilient defense providing a set of roaming, bio-inspired, digital-ant agents working with stationary agents in a hierarchy headed by a human supervisor. The ABCD approach provides a resilient, extensible, and flexible defense that can scale to large, multi-enterprise infrastructures like the smart electric grid.« less

Genetic and Genomic Insights into the Role of Benzoate-Catabolic Pathway Redundancy in Burkholderia xenovorans LB400†

PubMed Central

Denef, V. J.; Klappenbach, J. A.; Patrauchan, M. A.; Florizone, C.; Rodrigues, J. L. M.; Tsoi, T. V.; Verstraete, W.; Eltis, L. D.; Tiedje, J. M.

2006-01-01

Transcriptomic and proteomic analyses of Burkholderia xenovorans LB400, a potent polychlorinated biphenyl (PCB) degrader, have implicated growth substrate- and phase-dependent expression of three benzoate-catabolizing pathways: a catechol ortho cleavage (ben-cat) pathway and two benzoyl-coenzyme A pathways, encoded by gene clusters on the large chromosome (boxC) and the megaplasmid (boxM). To elucidate the significance of this apparent redundancy, we constructed mutants with deletions of the ben-cat pathway (the ΔbenABCD::kan mutant), the boxC pathway (the ΔboxABC::kan mutant), and both pathways (the ΔbenABCDΔ boxABC::kan mutant). All three mutants oxidized benzoate in resting-cell assays. However, the ΔbenABCD::kan and ΔbenABCD ΔboxABC::kan mutants grew at reduced rates on benzoate and displayed increased lag phases. By contrast, growth on succinate, on 4-hydroxybenzoate, and on biphenyl was unaffected. Microarray and proteomic analyses revealed that cells of the ΔbenABCD::kan mutant growing on benzoate expressed both box pathways. Overall, these results indicate that all three pathways catabolize benzoate. Deletion of benABCD abolished the ability of LB400 to grow using 3-chlorobenzoate. None of the benzoate pathways could degrade 2- or 4-chlorobenzoate, indicating that the pathway redundancy does not directly contribute to LB400's PCB-degrading capacities. Finally, an extensive sigmaE-regulated oxidative stress response not present in wild-type LB400 grown on benzoate was detected in these deletion mutants, supporting our earlier suggestion that the box pathways are preferentially active under reduced oxygen tension. Our data further substantiate the expansive network of tightly interconnected and complexly regulated aromatic degradation pathways in LB400. PMID:16391095

Amphotericin B Colloidal Dispersion Combined with Flucytosine with or without Fluconazole for Treatment of Murine Cryptococcal Meningitis

PubMed Central

Diamond, DeAnn M.; Bauer, Madeline; Daniel, Barbra E.; Leal, Mary Ann E.; Johnson, Debra; Williams, Byron K.; Thomas, Ann M.; Ding, James C.; Najvar, Laura; Graybill, J. Richard; Larsen, Robert A.

1998-01-01

Studies with animals and in vitro studies have demonstrated that flucytosine plus amphotericin B or fluconazole has significantly improved mycologic activity against meningitis caused by Cryptococcus neoformans compared to the activity of amphotericin B or fluconazole used alone. However, few doses have been tested in combination. This study evaluated the antifungal efficacy of amphotericin B colloidal dispersion (ABCD) combined with flucytosine with and without fluconazole in a murine model of cryptococcal meningitis. The following dosages were tested: ABCD at 0 to 12.5 mg/kg of body weight given intravenously 3 days/week, flucytosine at 0 to 110 mg/kg/day, and fluconazole at 0 to 50 mg/kg/day. Meningitis was established in male BALB/c mice by intracerebral injection of C. neoformans. Treatment with flucytosine with or without fluconazole dissolved in the sole source of drinking water was started on day 2; animals were sacrificed at 16 days, and the numbers of fungal colonies in the brain were quantified. A survival rate of 100% was achieved with ABCD plus flucytosine without fluconazole; however, the addition of fluconazole was required to prevent weight loss (P < 0.00001) and to achieve the maximum antifungal effect (P < 0.00001). The only region of dose combinations for which the 99% confidence intervals were less than 100 CFU/g of brain was defined by ABCD at 5.0 to 7.5 mg/kg combined with flucytosine at 20 to 60 mg/kg/day and fluconazole at 30 to 40 mg/kg/day. The triple combination of ABCD plus flucytosine and fluconazole was necessary to achieve the greatest antifungal activity. PMID:9517927

Catalytic function of the mycobacterial binuclear iron monooxygenase in acetone metabolism.

PubMed

Furuya, Toshiki; Nakao, Tomomi; Kino, Kuniki

2015-10-01

Mycobacteria such as Mycobacterium smegmatis strain mc(2)155 and Mycobacterium goodii strain 12523 are able to grow on acetone and use it as a source of carbon and energy. We previously demonstrated by gene deletion analysis that the mimABCD gene cluster, which encodes a binuclear iron monooxygenase, plays an essential role in acetone metabolism in these mycobacteria. In the present study, we determined the catalytic function of MimABCD in acetone metabolism. Whole-cell assays were performed using Escherichia coli cells expressing the MimABCD complex. When the recombinant E. coli cells were incubated with acetone, a product was detected by gas chromatography (GC) analysis. Based on the retention time and the gas chromatography-mass spectrometry (GC-MS) spectrum, the reaction product was identified as acetol (hydroxyacetone). The recombinant E. coli cells produced 1.02 mM of acetol from acetone within 24 h. Furthermore, we demonstrated that MimABCD also was able to convert methylethylketone (2-butanone) to 1-hydroxy-2-butanone. Although it has long been known that microorganisms such as mycobacteria metabolize acetone via acetol, this study provides the first biochemical evidence for the existence of a microbial enzyme that catalyses the conversion of acetone to acetol. © FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

A New Black Carbon Sensor for Dense Air Quality Monitoring Networks.

PubMed

Caubel, Julien J; Cados, Troy E; Kirchstetter, Thomas W

2018-03-01

Low-cost air pollution sensors are emerging and increasingly being deployed in densely distributed wireless networks that provide more spatial resolution than is typical in traditional monitoring of ambient air quality. However, a low-cost option to measure black carbon (BC)-a major component of particulate matter pollution associated with adverse human health risks-is missing. This paper presents a new BC sensor designed to fill this gap, the Aerosol Black Carbon Detector (ABCD), which incorporates a compact weatherproof enclosure, solar-powered rechargeable battery, and cellular communication to enable long-term, remote operation. This paper also demonstrates a data processing methodology that reduces the ABCD's sensitivity to ambient temperature fluctuations, and therefore improves measurement performance in unconditioned operating environments (e.g., outdoors). A fleet of over 100 ABCDs was operated outdoors in collocation with a commercial BC instrument (Magee Scientific, Model AE33) housed inside a regulatory air quality monitoring station. The measurement performance of the 105 ABCDs is comparable to the AE33. The fleet-average precision and accuracy, expressed in terms of mean absolute percentage error, are 9.2 ± 0.8% (relative to the fleet average data) and 24.6 ± 0.9% (relative to the AE33 data), respectively (fleet-average ± 90% confidence interval).

Role of CadC and CadD in the 2,4-dichlorophenoxyacetic acid oxygenase system of Sphingomonas agrestis 58-1.

PubMed

Kijima, Kumiko; Mita, Hajime; Kawakami, Mitsuyasu; Amada, Kei

2018-02-02

In the present study, we confirm that 2,4-dichlorophenoxyacetic acid (2,4-D) oxygenase from Sphingomonas agrestis 58-1 belongs to the family of Rieske non-heme iron aromatic ring-hydroxylating oxygenases, which comprise a core enzyme (oxygenase), ferredoxin, and oxidoreductase. It has previously been shown that cadAB genes are necessary for the conversion of 2,4-D to 2,4-dichlorophenol; however, the respective roles of ferredoxin and oxidoreductase in the 2,4-D oxygenase system from S. agrestis 58-1 remain unknown. Using nucleotide sequence analysis of the plasmid pCADAB1 from Sphingomonas sp. ERG5, which degrades 4-chloro-2-methylphenoxyacetic acid and 2,4-D, Nielsen et al. identified orf95, upstream of cadA, and orf98, downstream of cadB, which were predicted and designated as cadD (oxidoreductase) and cadC (ferredoxin), respectively (Nielsen et al., PLoS One, 8, 1-9, 2013). These designations were the result of sequence analysis; therefore, we constructed an expression system of CadABC and CadABCD in Escherichia coli and assayed their enzyme activities. Our findings indicate that CadC is essential for the activity of 2,4-D oxygenase and CadD promotes CadABC activity in recombinant E. coli cells. Copyright © 2018 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

Low-Temperature Molecular Layer Deposition Using Monofunctional Aromatic Precursors and Ozone-Based Ring-Opening Reactions.

PubMed

Svärd, Laura; Putkonen, Matti; Kenttä, Eija; Sajavaara, Timo; Krahl, Fabian; Karppinen, Maarit; Van de Kerckhove, Kevin; Detavernier, Christophe; Simell, Pekka

2017-09-26

Molecular layer deposition (MLD) is an increasingly used deposition technique for producing thin coatings consisting of purely organic or hybrid inorganic-organic materials. When organic materials are prepared, low deposition temperatures are often required to avoid decomposition, thus causing problems with low vapor pressure precursors. Monofunctional compounds have higher vapor pressures than traditional bi- or trifunctional MLD precursors, but do not offer the required functional groups for continuing the MLD growth in subsequent deposition cycles. In this study, we have used high vapor pressure monofunctional aromatic precursors in combination with ozone-triggered ring-opening reactions to achieve sustained sequential growth. MLD depositions were carried out by using three different aromatic precursors in an ABC sequence, namely with TMA + phenol + O 3 , TMA + 3-(trifluoromethyl)phenol + O 3 , and TMA + 2-fluoro-4-(trifluoromethyl)benzaldehyde + O 3 . Furthermore, the effect of hydrogen peroxide as a fourth step was evaluated for all studied processes resulting in a four-precursor ABCD sequence. According to the characterization results by ellipsometry, infrared spectroscopy, and X-ray reflectivity, self-limiting MLD processes could be obtained between 75 and 150 °C with each of the three aromatic precursors. In all cases, the GPC (growth per cycle) decreased with increasing temperature. In situ infrared spectroscopy indicated that ring-opening reactions occurred in each ABC sequence. Compositional analysis using time-of-flight elastic recoil detection indicated that fluorine could be incorporated into the film when 3-(trifluoromethyl)phenol and 2-fluoro-4-(trifluoromethyl)benzaldehyde were used as precursors.

Research on propagation properties of controllable hollow flat-topped beams in turbulent atmosphere based on ABCD matrix

NASA Astrophysics Data System (ADS)

Liu, Huilong; Lü, Yanfei; Zhang, Jing; Xia, Jing; Pu, Xiaoyun; Dong, Yuan; Li, Shutao; Fu, Xihong; Zhang, Angfeng; Wang, Changjia; Tan, Yong; Zhang, Xihe

2015-01-01

This paper studies the propagation properties of controllable hollow flat-topped beams (CHFBs) in turbulent atmosphere based on ABCD matrix, sets up a propagation model and obtains an analytical expression for the propagation. With the help of numerical simulation, the propagation properties of CHFBs in different parameters are studied. Results indicate that in turbulent atmosphere, with the increase of propagation distance, the darkness of CHFBs gradually annihilate, and eventually evolve into Gaussian beams. Compared with the propagation properties in free space, the turbulent atmosphere enhances the diffraction effect of CHFBs and reduces the propagation distance for CHFBs to evolve into Gaussian beams. In strong turbulence atmospheric propagation, Airy disk phenomenon will disappear. The study on the propagation properties of CHFBs in turbulence atmosphere by using ABCD matrix is simple and convenient. This method can also be applied to study the propagation properties of other hollow laser beams in turbulent atmosphere.

The Abcd Formula of Phase Definition in Optical Interferometry: Combined Effect of Air Dispersion and Broad Passband

NASA Astrophysics Data System (ADS)

Mathar, Richard J.

Long-baseline interferometry detects fringes created by superposition of two beams of light collected by two telescopes pointing into a common direction. The external path difference is commonly compensated by adding a variable optical path length (delay) through air for one beam such that the optical path difference between the beams remains close to zero near the detector. The ABCD formula assigns a (wrapped) phase to the signals A to D of an interference pattern shifted by multiples of 90 degrees in phase. We study the interplay between a broad spectral passband of the optics and the dispersion of the air in the compensating delay, which leads to small deviations between the ABCD phase and the reduced, monochromatic group-delay representation of the wave packets. This adds dispersion to the effects that have been discussed for evacuated interferometers before (Milman 2005).

Renyi generalizations of the conditional quantum mutual information

DTIC Science & Technology

2015-02-23

D) for a four-party pure state on systems ABCD. The conditional mutual information also underlies the squashed entanglement , an entanglement measure...that satisfies all of the axioms desired for an entanglement measure. As such, it has been an open question to find Rényi generalizations of the...possessing the C systems, and the sender and receiver sharing noiseless entanglement before communication begins, the optimal rate of quantum communication

Base Vehicle Equipment, Special Vehicle, General Purpose Vehicle, and Vehicle Body Mechanics Career Ladders, AFSs 472X0, 472X1A/B/C/D, 472X2 and 472X3.

DTIC Science & Technology

1982-08-01

brakes , belts, and carburetors; servicing air cleaners, oil systems , and drive belts; and lubricating vehicles. Although the six distinct jobs...vehicle systems . General Repair Mechanics repaired, inspected, serviced, and maintained electrical, brake , suspension, and other vehicle systems . This...installing intake or exhaust manifolds removing or installing parking- brake cables removing or’installing head assemblies inspecting gasoline fuel system

Implementing the ABCDE Bundle into Everyday Care: Opportunities, Challenges and Lessons Learned for Implementing the ICU Pain, Agitation and Delirium (PAD) Guidelines

PubMed Central

Balas, Michele C.; Burke, William J.; Gannon, David; Cohen, Marlene Z.; Colburn, Lois; Bevil, Catherine; Franz, Doug; Olsen, Keith M.; Ely, E. Wesley; Vasilevskis, Eduard E.

2014-01-01

Objective The Awakening and Breathing Coordination, Delirium monitoring/management and Early exercise/mobility (ABCDE) bundle is an evidence-based, interprofessional, multicomponent strategy for minimizing sedative exposure, reducing duration of mechanical ventilation and managing intensive care unit (ICU) acquired delirium and weakness. The purpose of this study was to identify facilitators and barriers to ABCDE bundle adoption and to evaluate the extent to which bundle implementation was effective, sustainable, and conducive to dissemination. Design Prospective, before-after, mixed-methods study. Setting Five adult ICUs, 1 step-down unit, and a special care unit located in a 624 bed, academic medical center Subjects Interprofessional ICU team members at participating institution. Interventions and Measurements In collaboration with the participating institution, we developed, implemented, and refined an ABCDE bundle policy. Over the course of an 18 month period, all ICU team members were offered the opportunity to participate in numerous, multimodal educational efforts. Three focus group sessions, 3 online surveys, and 1 educational evaluation were administered in an attempt to identify facilitators and barriers to bundle adoption. Main Results Factors believed to facilitate bundle implementation included: 1) the performance of daily, interdisciplinary, rounds, 2) engagement of key implementation leaders, 3) sustained and diverse educational efforts, and 4) the bundle's quality and strength. Barriers identified included: 1) intervention related issues (e.g. timing of trials, fear of adverse events), 2) communication and care coordination challenges, 3) knowledge deficits, 4) workload concerns, and 5) documentation burden. Despite these challenges, participants believed implementation ultimately benefited patients, improved interdisciplinary communication, and empowered nurses and other ICU team members. Conclusions In this study of the implementation of the ABCDE bundle in a tertiary care setting, clear factors were identified that both advanced and impeded adoption of this complex intervention that requires interprofessional education, coordination, and cooperation. Focusing on these factors preemptively should enable a more effective and lasting implementation of the bundle and better care for critically ill patients. Lessons learned from this study will also help healthcare providers optimize implementation of the recent ICU Pain, Agitation and Delirium (PAD) Guidelines, which has many similarities but also some important differences as compared to the ABCDE bundle PMID:23989089

Teaching Stable Two-Mirror Resonators through the Fractional Fourier Transform

ERIC Educational Resources Information Center

Moreno, Ignacio; Garcia-Martinez, Pascuala; Ferreira, Carlos

2010-01-01

We analyse two-mirror resonators in terms of their fractional Fourier transform (FRFT) properties. We use the basic ABCD ray transfer matrix method to show how the resonator can be regarded as the cascade of two propagation-lens-propagation FRFT systems. Then, we present a connection between the geometric properties of the resonator (the g…

The ABCD matrix for parabolic reflectors and its application to astigmatism free four-mirror cavities

NASA Astrophysics Data System (ADS)

Dupraz, K.; Cassou, K.; Martens, A.; Zomer, F.

2015-10-01

The ABCD matrix for parabolic reflectors is derived for any incident angles. It is used in numerical studies of four-mirror cavities composed of two flat and two parabolic mirrors. Constraints related to laser beam injection efficiency, optical stability, cavity-mode, beam-waist size and high stacking power are satisfied. A dedicated alignment procedure leading to stigmatic cavity-modes is employed to overcome issues related to the optical alignment of parabolic reflectors.

The ABCD2 score is better for stroke risk prediction after anterior circulation TIA compared to posterior circulation TIA.

PubMed

Wang, Junjun; Wu, Jimin; Liu, Rongyi; Gao, Feng; Hu, Haitao; Yin, Xinzhen

2015-01-01

Transient ischemic attacks (TIAs) are divided into anterior and posterior circulation types (AC-TIA, PC-TIA, respectively). In the present study, we sought to evaluate the ABCD2 score for predicting stroke in either AC-TIA or PC-TIA. We prospectively studied 369 consecutive patients who presented with TIA between June 2009 and December 2012. The 7 d occurrence of stroke after TIA was recorded and correlated with the ABCD2 score with regards to AC-TIA or PC-TIA. Overall, 273 AC-TIA and 96 PC-TIA patients were recruited. Twenty-one patients with AC-TIA and seven with PC-TIA developed a stroke within the subsequent 7 d (7.7% vs. 7.3%, p = 0.899). The ABCD2 score had a higher predictive value of stroke occurrence in AC-TIA (the AUC was 0.790; 95% CI, 0.677-0.903) than in PC-TIA (the AUC was 0.535; 95% CI, 0.350-0.727) and the z-value of two receiver operating characteristic (ROC) curves was 2.24 (p = 0.025). AC-TIA resulted in a higher incidence of both unilateral weakness and speech disturbance and longer durations of the symptoms. Inversely, PC-TIA was associated with a higher incidence of diabetes mellitus (19.8% vs. 10.6%, p = 0.022). Evaluating each component of scores, age ≥ 60 yr (OR = 7.010, 95% CI 1.599-30.743), unilateral weakness (OR = 3.455, 95% CI 1.131-10.559), and blood pressure (OR = 9.652, 95% CI 2.202-42.308) were associated with stroke in AC-TIA, while in PC-TIA, diabetes mellitus (OR = 9.990, 95% CI 1.895-52.650) was associated with stroke. In our study, the ABCD2 score could predict the short-term risk of stroke after AC-TIA, but might have limitation for PC-TIA.

ABCD3-I score and the risk of early or 3-month stroke recurrence in tissue- and time-based definitions of TIA and minor stroke.

PubMed

Mayer, Lukas; Ferrari, Julia; Krebs, Stefan; Boehme, Christian; Toell, Thomas; Matosevic, Benjamin; Tinchon, Alexander; Brainin, Michael; Gattringer, Thomas; Sommer, Peter; Thun, Peter; Willeit, Johann; Lang, Wilfried; Kiechl, Stefan; Knoflach, Michael

2018-03-01

Changing definition of TIA from time to a tissue basis questions the validity of the well-established ABCD3-I risk score for recurrent ischemic cerebrovascular events. We analyzed patients with ischemic stroke with mild neurological symptoms arriving < 24 h after symptom onset in a phase where it is unclear, if the event turns out to be a TIA or minor stroke, in the prospective multi-center Austrian Stroke Unit Registry. Patients were retrospectively categorized according to a time-based (symptom duration below/above 24 h) and tissue-based (without/with corresponding brain lesion on CT or MRI) definition of TIA or minor stroke. Outcome parameters were early stroke during stroke unit stay and 3-month ischemic stroke. Of the 5237 TIA and minor stroke patients with prospectively documented ABCD3-I score, 2755 (52.6%) had a TIA by the time-based and 2183 (41.7%) by the tissue-based definition. Of the 2457 (46.9%) patients with complete 3-month followup, corresponding numbers were 1195 (48.3%) for the time- and 971 (39.5%) for the tissue-based definition of TIA. Early and 3-month ischemic stroke occurred in 1.1 and 2.5% of time-based TIA, 3.8 and 5.9% of time-based minor stroke, 1.2 and 2.3% of tissue-based TIA as well as in 3.1 and 5.5% of tissue-based minor stroke patients. Irrespective of the definition of TIA and minor stroke, the risk of early and 3-month ischemic stroke steadily increased with increasing ABCD3-I score points. The ABCD3-I score performs equally in TIA patients in tissue- as well as time-based definition and the same is true for minor stroke patients.

Recent Developments In Theory Of Balanced Linear Systems

NASA Technical Reports Server (NTRS)

Gawronski, Wodek

1994-01-01

Report presents theoretical study of some issues of controllability and observability of system represented by linear, time-invariant mathematical model of the form. x = Ax + Bu, y = Cx + Du, x(0) = xo where x is n-dimensional vector representing state of system; u is p-dimensional vector representing control input to system; y is q-dimensional vector representing output of system; n,p, and q are integers; x(0) is intial (zero-time) state vector; and set of matrices (A,B,C,D) said to constitute state-space representation of system.

Quantum Dynamics Scattering Study of AB+CDE Reactions: A Seven Dimensional Treatment for the H2+C2H Reaction

NASA Technical Reports Server (NTRS)

Wang, Dunyou

2003-01-01

A time-dependent wave-packet approach is presented for the quantum dynamics study of the AB+CDE reaction system for zero total angular momentum. A seven-degree-of-freedom calculation is employed to study the chemical reaction of H2+C2H yields H + C2H2 by treating C2H as a linear molecule. Initial state selected reaction probabilities are presented for various initial ro-vibrational states. This study shows that vibrational excitation of H2 enhances the reaction probability, whereas the excitation of C2H has only a small effect on the reactivity. An integral cross section is also reported for the initial ground states of H2 and C2H. The theoretical and experimental results agree with each other very well when the calculated seven dimensional results are adjusted to account for the lower transition state barrier heights found in recent ab initio calculations.

Identification of New Virulence Factors and Vaccine Candidates for Yersinia pestis

PubMed Central

Andersson, Jourdan A.; Sha, Jian; Erova, Tatiana E.; Fitts, Eric C.; Ponnusamy, Duraisamy; Kozlova, Elena V.; Kirtley, Michelle L.; Chopra, Ashok K.

2017-01-01

Earlier, we reported the identification of new virulence factors/mechanisms of Yersinia pestis using an in vivo signature-tagged mutagenesis (STM) screening approach. From this screen, the role of rbsA, which encodes an ATP-binding protein of ribose transport system, and vasK, an essential component of the type VI secretion system (T6SS), were evaluated in mouse models of plague and confirmed to be important during Y. pestis infection. However, many of the identified genes from the screen remained uncharacterized. In this study, in-frame deletion mutants of ypo0815, ypo2884, ypo3614-3168 (cyoABCDE), and ypo1119-1120, identified from the STM screen, were generated. While ypo0815 codes for a general secretion pathway protein E (GspE) of the T2SS, the ypo2884-encoded protein has homology to the βγ crystallin superfamily, cyoABCDE codes for the cytochrome o oxidase operon, and the ypo1119-1120 genes are within the Tol-Pal system which has multiple functions. Additionally, as our STM screen identified three T6SS-associated genes, and, based on in silico analysis, six T6SS clusters and multiple homologs of the T6SS effector hemolysin-coregulated protein (Hcp) exist in Y. pestis CO92, we also targeted these T6SS clusters and effectors for generating deletion mutants. These deletion mutant strains exhibited varying levels of attenuation (up to 100%), in bubonic or pneumonic murine infection models. The attenuation could be further augmented by generation of combinatorial deletion mutants, namely ΔlppΔypo0815, ΔlppΔypo2884, ΔlppΔcyoABCDE, ΔvasKΔhcp6, and Δypo2720-2733Δhcp3. We earlier showed that deletion of the lpp gene, which encodes Braun lipoprotein (Lpp) and activates Toll-like receptor-2, reduced virulence of Y. pestis CO92 in murine models of bubonic and pneumonic plague. The surviving mice infected with ΔlppΔcyoABCDE, ΔvasKΔhcp6, and Δypo2720-2733Δhcp3 mutant strains were 55–100% protected upon subsequent re-challenge with wild-type CO92 in a pneumonic model. Further, evaluation of the attenuated T6SS mutant strains in vitro revealed significant alterations in phagocytosis, intracellular survival in murine macrophages, and their ability to induce cytotoxic effects on macrophages. The results reported here provide further evidence of the utility of the STM screening approach for the identification of novel virulence factors and to possibly target such genes for the development of novel live-attenuated vaccine candidates for plague. PMID:29090192

Identification of New Virulence Factors and Vaccine Candidates for Yersinia pestis.

PubMed

Andersson, Jourdan A; Sha, Jian; Erova, Tatiana E; Fitts, Eric C; Ponnusamy, Duraisamy; Kozlova, Elena V; Kirtley, Michelle L; Chopra, Ashok K

2017-01-01

Earlier, we reported the identification of new virulence factors/mechanisms of Yersinia pestis using an in vivo signature-tagged mutagenesis (STM) screening approach. From this screen, the role of rbsA , which encodes an ATP-binding protein of ribose transport system, and vasK , an essential component of the type VI secretion system (T6SS), were evaluated in mouse models of plague and confirmed to be important during Y. pestis infection. However, many of the identified genes from the screen remained uncharacterized. In this study, in-frame deletion mutants of ypo0815, ypo2884, ypo3614-3168 (cyoABCDE) , and ypo1119-1120 , identified from the STM screen, were generated. While ypo0815 codes for a general secretion pathway protein E (GspE) of the T2SS, the ypo2884 -encoded protein has homology to the βγ crystallin superfamily, cyoABCDE codes for the cytochrome o oxidase operon, and the ypo1119-1120 genes are within the Tol-Pal system which has multiple functions. Additionally, as our STM screen identified three T6SS-associated genes, and, based on in silico analysis, six T6SS clusters and multiple homologs of the T6SS effector hemolysin-coregulated protein (Hcp) exist in Y. pestis CO92, we also targeted these T6SS clusters and effectors for generating deletion mutants. These deletion mutant strains exhibited varying levels of attenuation (up to 100%), in bubonic or pneumonic murine infection models. The attenuation could be further augmented by generation of combinatorial deletion mutants, namely Δ lpp Δ ypo0815 , Δ lpp Δ ypo2884 , Δ lpp Δ cyoABCDE , Δ vasK Δ hcp6 , and Δ ypo2720-2733 Δ hcp3 . We earlier showed that deletion of the lpp gene, which encodes Braun lipoprotein (Lpp) and activates Toll-like receptor-2, reduced virulence of Y. pestis CO92 in murine models of bubonic and pneumonic plague. The surviving mice infected with Δ lpp Δ cyoABCDE , Δ vasK Δ hcp6 , and Δ ypo2720-2733 Δ hcp3 mutant strains were 55-100% protected upon subsequent re-challenge with wild-type CO92 in a pneumonic model. Further, evaluation of the attenuated T6SS mutant strains in vitro revealed significant alterations in phagocytosis, intracellular survival in murine macrophages, and their ability to induce cytotoxic effects on macrophages. The results reported here provide further evidence of the utility of the STM screening approach for the identification of novel virulence factors and to possibly target such genes for the development of novel live-attenuated vaccine candidates for plague.

Assessing appearance-related disturbances in HIV-infected men who have sex with men (MSM): psychometrics of the body change and distress questionnaire-short form (ABCD-SF).

PubMed

Blashill, Aaron J; Wilson, Johannes M; Baker, Joshua S; Mayer, Kenneth H; Safren, Steven A

2014-06-01

Appearance-related disturbances are common among HIV-infected MSM; however, to date, there have been limited options in the valid assessment of this construct. The aim of the current study was to assess the structural, internal, and convergent validity of the assessment of body change distress questionnaire (ABCD) and its short version. Exploratory and confirmatory factor analyses indicated that both versions fit the data well. Four subfactors were revealed measuring the following body disturbance constructs: (1) negative affect about appearance, (2) HIV health-related outcomes and stigma, (3) eating and exercise confusion, and (4) ART non-adherence. The subfactors and total scores revealed bivariate associations with salient health outcomes, including depressive symptoms, HIV sexual transmission risk behaviors, and ART non-adherence. The ABCD and its short form, offer valid means to assess varied aspects of body image disturbance among HIV-infected MSM, and require modest participant burden.

Laypersons' perceptual discrimination of pigmented skin lesions.

PubMed

Bränström, Richard; Hedblad, Mari-Anne; Krakau, Ingvar; Ullén, Henrik

2002-05-01

Most cutaneous malignant melanomas of the skin are visible and should, at least in theory, be possible to detect with the naked eye. This study was conducted to learn more about laypersons' ability to discriminate between benign pigmented lesions and malignant ones. Four groups of laypersons (n = 120) were asked to evaluate pictures of different types of pigmented skin lesions, before and after they received information about the ABCD (asymmetry, border irregularity, color variegation, and diameter greater than 6 mm) criteria, with respect to the necessity of action. The respondents made adequate assessments of melanomas but overestimated the danger of benign pigmented skin lesions. Information about the ABCD criteria enhanced their ability to make adequate assessments. People seem to make adequate decisions concerning how to act if they have a melanoma. On the other hand, common moles and dysplastic nevi were harder to discriminate. Providing information to the public about the features of melanomas, in accordance with the ABCD criteria, might help laypersons in their perceptual discrimination of skin lesions.

From clinical to tissue-based dual TIA: Validation and refinement of ABCD3-I score.

PubMed

Dai, Qiliang; Sun, Wen; Xiong, Yunyun; Hankey, Graeme J; Xiao, Lulu; Zhu, Wusheng; Ma, Minmin; Liu, Wenhua; Liu, Dezhi; Cai, Qiankun; Han, Yunfei; Duan, Lihui; Chen, Xiangliang; Xu, Gelin; Liu, Xinfeng

2015-04-07

To investigate whether dual tissue-defined ischemic attacks, defined as multiple diffusion-weighted imaging lesions of different age and/or arterial territory (dual DWI), are an independent and stronger predictor of 90-day stroke than dual clinical TIAs (dual TIA). Consecutive patients with clinically defined TIA were enrolled and assessed clinically and by MRI within 3 days. The predictive ability of the ABCD clinical factors, dual TIA, and dual DWI was evaluated by means of multivariate logistic regression. Among 658 patients who were included in the study and completed 90 days of follow-up, a total of 70 patients (10.6%) experienced subsequent stroke by 90 days. Multivariate logistic regression indicated that dual DWI was an independent predictor for subsequent stroke (odds ratio 4.64, 95% confidence interval 2.15-10.01), while dual TIA was not (odds ratio 1.18, 95% confidence interval 0.69-2.01). C statistics was higher when the item of dual TIA in ABCD3-I score was replaced by dual DWI (0.759 vs 0.729, p = 0.035). The net reclassification value for 90-day stroke risk was also improved (continuous net reclassification improvement 0.301, p = 0.017). Dual DWI independently predicted future stroke in patients with TIA. A new ABCD3-I score with dual DWI instead of dual clinical TIA may improve risk stratification for early stroke risk after TIA. © 2015 American Academy of Neurology.

Phosphite Utilization by the Globally Important Marine Diazotroph Trichodesmium

NASA Astrophysics Data System (ADS)

Polyviou, D.; Hitchcock, A.; Baylay, A. J.; Moore, C. M.; Bibby, T. S.

2016-02-01

The marine cyanobacterium Trichodesmium is responsible for a significant fraction of oceanic nitrogen fixation and plays a key role in biogeochemical processes in the contemporary ocean. It has recently been shown that it also contributes to an emerging oceanic phosphorus (P) redox cycle. This is of interest as the availability of P constrains the growth of Trichodesmium in large expanses of the tropical and subtropical oceans. A four-gene cluster (ptxABCD) encodes a putative ABC transporter (ptxABC) and NAD-dependent dehydrogenase (ptxD) and is suggested to be involved in utilisation of the reduced inorganic compound phosphite. The gene cluster is identified in the Trichodesmium erythraeum IMS101 genome (Tery_0365-0368). Here, we report the occurrence of these genes in available in-situ metagenomic and metatranscriptomic datasets confirming the presence and expression of ptxABCD in diverse Trichodesmium species in the field. We also demonstrate that T.erythraeum IMS101 in culture can grow on phosphite as its sole source of P. The current lack of an established system for genetic manipulation of this organism inhibits direct functional characterisation of ptxABCD. To circumvent this we exploit the model cyanobacteria Synechocystis PCC6803 as a vehicle for the heterologous expression of the Trichodesmium genes. We demonstrate that only combined expression of both the transporter and the dehydrogenase enables Synechocystis to utilize phosphite, confirming the function of Tery_0365-0367 as a phosphite uptake system (PtxABC) and Tery_0368 as a phosphite dehydrogenase (PtxD). Our findings suggest that previously reported uptake of phosphite by Trichodesmium consortia in the field likely reflects an active biological process by Trichodesmium itself. These results highlight the diversity of phosphorus sources available to Trichodesmium in a resource-limited ocean and also the power of using heterologous gene expression to determine the function of genes identified in marine microbes.

The ABCD's of 5'-adenosine monophosphate-activated protein kinase and adrenoleukodystrophy.

PubMed

Weidling, Ian; Swerdlow, Russell H

2016-07-01

This Editorial highlights a study by Singh and coworkers in the current issue of Journal of Neurochemistry, in which the authors present additional evidence that AMPKα1 is reduced in X-linked adrenoleukodystrophy (X-ALD). They make a case for increasing AMPKα1 activity for therapeutic purposes in this disease, and indicate how this goal may be achieved. Read the highlighted article 'Metformin-induced mitochondrial function and ABCD2 up regulation in X-linked adrenoleukodystrophy involves AMP activated protein kinase' on page 86. © 2016 International Society for Neurochemistry.

Crisis on campus: Eating disorder intervention from a developmental-ecological perspective.

PubMed

Taylor, Julia V; Gibson, Donna M

2016-01-01

The purpose of this article is to review a crisis intervention using the developmental-ecological protocol (Collins and Collins, 2005) with a college student presenting with symptomatology of an active eating disorder. Participants included University Wellness Center employees responding to the crisis. Methods include an informal review of the crisis intervention response and application of the ABCDE developmental-ecological crisis model. Results reported include insight into crisis intervention when university counseling and health center is not available as resources. ABCDE Developmental-ecological model recommendations for university faculty and staff are included.

Monoclinic structures of niobium trisulfide

NASA Astrophysics Data System (ADS)

Bloodgood, Matthew A.; Wei, Pingrong; Aytan, Ece; Bozhilov, Krassimir N.; Balandin, Alexander A.; Salguero, Tina T.

2018-02-01

Two new polymorphs of niobium trisulfide are established by single crystal x-ray diffraction. NbS3-iv crystallizes in the monoclinic space group P21/c with lattice parameters a = 6.7515(5) Å, b = 4.9736(4) Å, c = 18.1315(13) Å, and β = 90.116(2)°. Its structure is based on chains of [NbS6] trigonal prisms containing Nb-Nb pairs with a bond length of 3.0448(8) Å; this pairing causes the chains to corrugate slightly along their axis, a feature also present in triclinic NbS3-i that leads to semiconductor properties. The stacking arrangement of chains is different in these polymorphs, however, with NbS3-i having an ABCDE repeating sequence of chain bilayers and NbS3-iv having an AB repeating sequence. HRTEM studies show the presence of topotactically-oriented intergrown zones and numerous dislocations, which result in mosaic structuring. A second new polymorph, NbS3-v, crystallizes in the monoclinic space group P21/m with lattice parameters a = 4.950(5) Å, b = 3.358(4) Å, c = 9.079(10) Å, β = 97.35(2)°. In contrast to NbS3-iv, NbS3-v maintains fixed a Nb-Nb bond distance of 3.358(4) Å along the chains, and it has an ABCDE repeating sequence of chain bilayers similar to NbS3-i. High resolution scanning transmission electron microscopy (HR-STEM) imaging of an exfoliated NbS3-v nanoribbon shows the continuous [NbS6] chains oriented along the b-axis. These results provide the first firmly established structural data for monoclinic NbS3. In addition, SEM images show the formation of NbS3 rings and cylinders, and a combination of powder x-ray diffraction and Raman spectroscopy provides a way to distinguish between NbS3 polymorphs.

Michigan Residents Grade Their Schools: Results from the 2003 State of the State Survey. Policy Report No. 19

ERIC Educational Resources Information Center

Reimann, Christopher B.; Lee, Kwanghyun; Donahue, Tara

2004-01-01

The State Board of Education and the Michigan Department of Education are about to publish letter grades for each of the state's 4,015 public elementary, middle and high schools. These grades are part of "Education Yes!", Michigan's new school accreditation system. The familiar ABCD/F grades of their youth will provide parents and the…

Adult-onset cerebello-brainstem dominant form of X-linked adrenoleukodystrophy presenting as multiple system atrophy: Case report and literature review

PubMed Central

Ogaki, Kotaro; Koga, Shunsuke; Aoki, Naoya; Lin, Wenlang; Suzuki, Kinuko; Ross, Owen A.; Dickson, Dennis W.

2015-01-01

X-linked adrenoleukodystrophy (X-ALD) is the most common peroxisomal disorder and is caused by ABCD1 mutations. A cerebello-brainstem dominant form that mainly involves the cerebellum and brainstem is summarized in a review of the literature, with autopsy confirmed cases exceedingly rare. We report a 69-year-old white man who was diagnosed with this rare disorder and describe neuropathologic, ultrastructural and genetic analyses. He did not have adrenal insufficiency or a family history of X-ALD or Addison’s disease. His initial symptom was temporary loss of eyesight at age 34 years. His major symptoms were chronic and progressive gait disorder, weakness in his lower extremities, and spasticity, as well as autonomic failure and cerebellar ataxia suggesting possible multiple system atrophy (MSA). He also had seizures, hearing loss, and sensory disturbances. His brain MRI showed no obvious atrophy or significant white matter pathology in cerebrum, brainstem or cerebellum. He died at age 69 years with a diagnosis of multiple system atrophy. Microscopic analysis showed mild, patchy myelin rarefaction with perivascular clusters of PAS-positive, CD68-positive macrophages in the white matter most prominent in the cerebellum and occipital lobe, but also affecting optic tract and internal capsule. Electron microscopy of cerebellar white matter showed cleft-like trilamellar cytoplasmic inclusions in macrophages typical of X-ALD, which prompted genetic analysis that revealed a novel ABCD1 mutation, p.R163G. Given the relatively mild pathological findings and long disease duration, it is likely that the observed pathology was the result of a slow and indolent disease process. We described a patient who had sporadic cerebello-brainstem dominant form of X-ALD with long clinical course, mild pathological findings, and an ABCD1 p.R163G substitution. We also review a total of 34 cases of adult-onset cerebello-brainstem dominant form of X-ALD. Although rare, X-ALD should be considered in the differential diagnosis of MSA. PMID:26227820

An assessment of the cost-effectiveness of magnetic resonance, including diffusion-weighted imaging, in patients with transient ischaemic attack and minor stroke: a systematic review, meta-analysis and economic evaluation.

PubMed

Wardlaw, Joanna; Brazzelli, Miriam; Miranda, Hector; Chappell, Francesca; McNamee, Paul; Scotland, Graham; Quayyum, Zahid; Martin, Duncan; Shuler, Kirsten; Sandercock, Peter; Dennis, Martin

2014-04-01

Patients with transient ischaemic attack (TIA) or minor stroke need rapid treatment of risk factors to prevent recurrent stroke. ABCD2 score or magnetic resonance diffusion-weighted brain imaging (MR DWI) may help assessment and treatment. Is MR with DWI cost-effective in stroke prevention compared with computed tomography (CT) brain scanning in all patients, in specific subgroups or as 'one-stop' brain-carotid imaging? What is the current UK availability of services for stroke prevention? Published literature; stroke registries, audit and randomised clinical trials; national databases; survey of UK clinical and imaging services for stroke; expert opinion. Systematic reviews and meta-analyses of published/unpublished data. Decision-analytic model of stroke prevention including on a 20-year time horizon including nine representative imaging scenarios. The pooled recurrent stroke rate after TIA (53 studies, 30,558 patients) is 5.2% [95% confidence interval (CI) 3.9% to 5.9%] by 7 days, and 6.7% (5.2% to 8.7%) at 90 days. ABCD2 score does not identify patients with key stroke causes or identify mimics: 66% of specialist-diagnosed true TIAs and 35-41% of mimics had an ABCD2 score of ≥ 4; 20% of true TIAs with ABCD2 score of < 4 had key risk factors. MR DWI (45 studies, 9078 patients) showed an acute ischaemic lesion in 34.3% (95% CI 30.5% to 38.4%) of TIA, 69% of minor stroke patients, i.e. two-thirds of TIA patients are DWI negative. TIA mimics (16 studies, 14,542 patients) make up 40-45% of patients attending clinics. UK survey (45% response) showed most secondary prevention started prior to clinic, 85% of primary brain imaging was same-day CT; 51-54% of patients had MR, mostly additional to CT, on average 1 week later; 55% omitted blood-sensitive MR sequences. Compared with 'CT scan all patients' MR was more expensive and no more cost-effective, except for patients presenting at > 1 week after symptoms to diagnose haemorrhage; strategies that triaged patients with low ABCD2 scores for slow investigation or treated DWI-negative patients as non-TIA/minor stroke prevented fewer strokes and increased costs. 'One-stop' CT/MR angiographic-plus-brain imaging was not cost-effective. Data on sensitivity/specificity of MR in TIA/minor stroke, stroke costs, prognosis of TIA mimics and accuracy of ABCD2 score by non-specialists are sparse or absent; all analysis had substantial heterogeneity. Magnetic resonance with DWI is not cost-effective for secondary stroke prevention. MR was most helpful in patients presenting at > 1 week after symptoms if blood-sensitive sequences were used. ABCD2 score is unlikely to facilitate patient triage by non-stroke specialists. Rapid specialist assessment, CT brain scanning and identification of serious underlying stroke causes is the most cost-effective stroke prevention strategy. The National Institute for Health Research Health Technology Assessment programme.

The BaeSR Two-Component Regulatory System Mediates Resistance to Condensed Tannins in Escherichia coli▿ †

PubMed Central

Zoetendal, Erwin G.; Smith, Alexandra H.; Sundset, Monica A.; Mackie, Roderick I.

2008-01-01

The gene expression profiles of Escherichia coli strains grown anaerobically with or without Acacia mearnsii (black wattle) extract were compared to identify tannin resistance strategies. The cell envelope stress protein gene spy and the multidrug transporter-encoding operon mdtABCD, both under the control of the BaeSR two-component regulatory system, were significantly up-regulated in the presence of tannins. BaeSR mutants were more tannin sensitive than their wild-type counterparts. PMID:18039828

Wigner distribution function of Hermite-cosine-Gaussian beams through an apertured optical system.

PubMed

Sun, Dong; Zhao, Daomu

2005-08-01

By introducing the hard-aperture function into a finite sum of complex Gaussian functions, the approximate analytical expressions of the Wigner distribution function for Hermite-cosine-Gaussian beams passing through an apertured paraxial ABCD optical system are obtained. The analytical results are compared with the numerically integrated ones, and the absolute errors are also given. It is shown that the analytical results are proper and that the calculation speed for them is much faster than for the numerical results.

Adolescent brain cognitive development (ABCD) study: Overview of substance use assessment methods.

PubMed

Lisdahl, Krista M; Sher, Kenneth J; Conway, Kevin P; Gonzalez, Raul; Feldstein Ewing, Sarah W; Nixon, Sara Jo; Tapert, Susan; Bartsch, Hauke; Goldstein, Rita Z; Heitzeg, Mary

2018-08-01

One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

Study protocol: Audit and Best Practice for Chronic Disease Extension (ABCDE) Project.

PubMed

Bailie, Ross; Si, Damin; Connors, Christine; Weeramanthri, Tarun; Clark, Louise; Dowden, Michelle; O'Donohue, Lynette; Condon, John; Thompson, Sandra; Clelland, Nikki; Nagel, Tricia; Gardner, Karen; Brown, Alex

2008-09-17

A growing body of international literature points to the importance of a system approach to improve the quality of care in primary health care settings. Continuous Quality Improvement (CQI) concepts and techniques provide a theoretically coherent and practical way for primary care organisations to identify, address, and overcome the barriers to improvements. The Audit and Best Practice for Chronic Disease (ABCD) study, a CQI-based quality improvement project conducted in Australia's Northern Territory, has demonstrated significant improvements in primary care service systems, in the quality of clinical service delivery and in patient outcomes related to chronic illness care. The aims of the extension phase of this study are to examine factors that influence uptake and sustainability of this type of CQI activity in a variety of Indigenous primary health care organisations in Australia, and to assess the impact of collaborative CQI approaches on prevention and management of chronic illness and health outcomes in Indigenous communities. The study will be conducted in 40-50 Indigenous community health centres from 4 States/Territories (Northern Territory, Western Australia, New South Wales and Queensland) over a five year period. The project will adopt a participatory, quality improvement approach that features annual cycles of: 1) organisational system assessment and audits of clinical records; 2) feedback to and interpretation of results with participating health centre staff; 3) action planning and goal setting by health centre staff to achieve system changes; and 4) implementation of strategies for change. System assessment will be carried out using a System Assessment Tool and in-depth interviews of key informants. Clinical audit tools include two essential tools that focus on diabetes care audit and preventive service audit, and several optional tools focusing on audits of hypertension, heart disease, renal disease, primary mental health care and health promotion. The project will be carried out in a form of collaborative characterised by a sequence of annual learning cycles with action periods for CQI activities between each learning cycle. Key outcome measures include uptake and integration of CQI activities into routine service activity, state of system development, delivery of evidence-based services, intermediate patient outcomes (e.g. blood pressure and glucose control), and health outcomes (complications, hospitalisations and mortality). The ABCD Extension project will contribute directly to the evidence base on effectiveness of collaborative CQI approaches on prevention and management of chronic disease in Australia's Indigenous communities, and to inform the operational and policy environments that are required to incorporate CQI activities into routine practice.

Study protocol: Audit and Best Practice for Chronic Disease Extension (ABCDE) Project

PubMed Central

Bailie, Ross; Si, Damin; Connors, Christine; Weeramanthri, Tarun; Clark, Louise; Dowden, Michelle; O'Donohue, Lynette; Condon, John; Thompson, Sandra; Clelland, Nikki; Nagel, Tricia; Gardner, Karen; Brown, Alex

2008-01-01

Background A growing body of international literature points to the importance of a system approach to improve the quality of care in primary health care settings. Continuous Quality Improvement (CQI) concepts and techniques provide a theoretically coherent and practical way for primary care organisations to identify, address, and overcome the barriers to improvements. The Audit and Best Practice for Chronic Disease (ABCD) study, a CQI-based quality improvement project conducted in Australia's Northern Territory, has demonstrated significant improvements in primary care service systems, in the quality of clinical service delivery and in patient outcomes related to chronic illness care. The aims of the extension phase of this study are to examine factors that influence uptake and sustainability of this type of CQI activity in a variety of Indigenous primary health care organisations in Australia, and to assess the impact of collaborative CQI approaches on prevention and management of chronic illness and health outcomes in Indigenous communities. Methods/design The study will be conducted in 40–50 Indigenous community health centres from 4 States/Territories (Northern Territory, Western Australia, New South Wales and Queensland) over a five year period. The project will adopt a participatory, quality improvement approach that features annual cycles of: 1) organisational system assessment and audits of clinical records; 2) feedback to and interpretation of results with participating health centre staff; 3) action planning and goal setting by health centre staff to achieve system changes; and 4) implementation of strategies for change. System assessment will be carried out using a System Assessment Tool and in-depth interviews of key informants. Clinical audit tools include two essential tools that focus on diabetes care audit and preventive service audit, and several optional tools focusing on audits of hypertension, heart disease, renal disease, primary mental health care and health promotion. The project will be carried out in a form of collaborative characterised by a sequence of annual learning cycles with action periods for CQI activities between each learning cycle. Key outcome measures include uptake and integration of CQI activities into routine service activity, state of system development, delivery of evidence-based services, intermediate patient outcomes (e.g. blood pressure and glucose control), and health outcomes (complications, hospitalisations and mortality). Conclusion The ABCD Extension project will contribute directly to the evidence base on effectiveness of collaborative CQI approaches on prevention and management of chronic disease in Australia's Indigenous communities, and to inform the operational and policy environments that are required to incorporate CQI activities into routine practice. PMID:18799011

Whole brain CT perfusion deficits using 320-detector-row CT scanner in TIA patients are associated with ABCD2 score.

PubMed

Mehta, Bijal K; Mustafa, Ghulam; McMurtray, Aaron; Masud, Mohammed W; Gunukula, Sameer K; Kamal, Haris; Kandel, Amit; Beltagy, Abdelrahman; Li, Ping

2014-01-01

Transient ischemic attacks (TIA) are cerebral ischemic events without infarction. The uses of CT perfusion (CTP) techniques such as cerebral blood volume (CBV), time to peak (TTP), mean transit time (MTT) and cerebral blood flow (CBF) provide real time data about ischemia. It has been shown that CTP changes occur in less sensitive CTP scanners in patients with TIA. Larger detector row CTP (whole brain perfusion studies) may show that CTP abnormalities are more prevalent than previously noted. It is also unclear if these changes are associated with TIA severity. To demonstrate that TIA patients are associated with perfusion deficits using whole brain 320-detector-row CT perfusion, and to determine an association between ABCD2 score and perfusion deficit using whole brain perfusion. We retrospectively reviewed all TIA patients for CTP deficits from 2008-2010. Perfusion imaging was reviewed at admission; and it was determined if a perfusion deficit was present along with vascular territory involved. Of 364 TIA patients, 62 patients had CTP deficits. The largest group of patients had MCA territory involved with 48 of 62 patients (77.42%). The most common perfusion abnormality was increased TTP with 46 patients (74.19%). The ABCD2 score was reviewed in association with perfusion deficit. Increased age >60, severe hypertension (>180/100 mmHg), patients with speech abnormalities, and duration of symptoms >10 min were associated with a perfusion deficit but history of diabetes or minimal/moderate hypertension (140/90-179/99 mmHg) was not. There was no association between motor deficit and perfusion abnormality. Perfusion deficits are found in TIA patients using whole brain CTP and associated with components of the ABCD2 score.

A Specialized Aspartokinase Enhances the Biosynthesis of the Osmoprotectants Ectoine and Hydroxyectoine in Pseudomonas stutzeriA1501▿ †

PubMed Central

Stöveken, Nadine; Pittelkow, Marco; Sinner, Tatjana; Jensen, Roy A.; Heider, Johann; Bremer, Erhard

2011-01-01

The compatible solutes ectoine and hydroxyectoine are widely produced by bacteria as protectants against osmotic and temperature stress. l-Aspartate-beta-semialdehyde is used as the precursor molecule for ectoine/hydroxyectoine biosynthesis that is catalyzed by the EctABCD enzymes. l-Aspartate-beta-semialdehyde is a central intermediate in different biosynthetic pathways and is produced from l-aspartate by aspartokinase (Ask) and aspartate-semialdehyde-dehydrogenase (Asd). Ask activity is typically stringently regulated by allosteric control to avoid gratuitous synthesis of aspartylphosphate. Many organisms have evolved multiple forms of aspartokinase, and feedback regulation of these specialized Ask enzymes is often adapted to the cognate biochemical pathways. The ectoine/hydroxyectoine biosynthetic genes (ectABCD) are followed in a considerable number of microorganisms by an askgene (ask_ect), suggesting that Ask_Ect is a specialized enzyme for this osmoadaptive biosynthetic pathway. However, none of these Ask_Ect enzymes have been functionally characterized. Pseudomonas stutzeriA1501 synthesizes both ectoine and hydroxyectoine in response to increased salinity, and it possesses two Ask enzymes: Ask_Lys and Ask_Ect. We purified both Ask enzymes and found significant differences with regard to their allosteric control: Ask_LysC was inhibited by threonine and in a concerted fashion by threonine and lysine, whereas Ask_Ect showed inhibition only by threonine. The ectABCD_askgenes from P. stutzeriA1501 were cloned and functionally expressed in Escherichia coli, and this led to osmostress protection. An E. colistrain carrying the plasmid-based ectABCD_askgene cluster produced significantly more ectoine/hydroxyectoine than a strain expressing the ectABCDgene cluster alone. This finding suggests a specialized role for Ask_Ect in ectoine/hydroxyectoine biosynthesis. PMID:21725014

Bacillus subtilis as a Platform for Molecular Characterisation of Regulatory Mechanisms of Enterococcus faecalis Resistance against Cell Wall Antibiotics

PubMed Central

Fang, Chong; Stiegeler, Emanuel; Cook, Gregory M.; Mascher, Thorsten; Gebhard, Susanne

2014-01-01

To combat antibiotic resistance of Enterococcus faecalis, a better understanding of the molecular mechanisms, particularly of antibiotic detection, signal transduction and gene regulation is needed. Because molecular studies in this bacterium can be challenging, we aimed at exploiting the genetically highly tractable Gram-positive model organism Bacillus subtilis as a heterologous host. Two fundamentally different regulators of E. faecalis resistance against cell wall antibiotics, the bacitracin sensor BcrR and the vancomycin-sensing two-component system VanSB-VanRB, were produced in B. subtilis and their functions were monitored using target promoters fused to reporter genes (lacZ and luxABCDE). The bacitracin resistance system BcrR-BcrAB of E. faecalis was fully functional in B. subtilis, both regarding regulation of bcrAB expression and resistance mediated by the transporter BcrAB. Removal of intrinsic bacitracin resistance of B. subtilis increased the sensitivity of the system. The lacZ and luxABCDE reporters were found to both offer sensitive detection of promoter induction on solid media, which is useful for screening of large mutant libraries. The VanSB-VanRB system displayed a gradual dose-response behaviour to vancomycin, but only when produced at low levels in the cell. Taken together, our data show that B. subtilis is a well-suited host for the molecular characterization of regulatory systems controlling resistance against cell wall active compounds in E. faecalis. Importantly, B. subtilis facilitates the careful adjustment of expression levels and genetic background required for full functionality of the introduced regulators. PMID:24676422

Bacillus subtilis as a platform for molecular characterisation of regulatory mechanisms of Enterococcus faecalis resistance against cell wall antibiotics.

PubMed

Fang, Chong; Stiegeler, Emanuel; Cook, Gregory M; Mascher, Thorsten; Gebhard, Susanne

2014-01-01

To combat antibiotic resistance of Enterococcus faecalis, a better understanding of the molecular mechanisms, particularly of antibiotic detection, signal transduction and gene regulation is needed. Because molecular studies in this bacterium can be challenging, we aimed at exploiting the genetically highly tractable Gram-positive model organism Bacillus subtilis as a heterologous host. Two fundamentally different regulators of E. faecalis resistance against cell wall antibiotics, the bacitracin sensor BcrR and the vancomycin-sensing two-component system VanSB-VanRB, were produced in B. subtilis and their functions were monitored using target promoters fused to reporter genes (lacZ and luxABCDE). The bacitracin resistance system BcrR-BcrAB of E. faecalis was fully functional in B. subtilis, both regarding regulation of bcrAB expression and resistance mediated by the transporter BcrAB. Removal of intrinsic bacitracin resistance of B. subtilis increased the sensitivity of the system. The lacZ and luxABCDE reporters were found to both offer sensitive detection of promoter induction on solid media, which is useful for screening of large mutant libraries. The VanSB-VanRB system displayed a gradual dose-response behaviour to vancomycin, but only when produced at low levels in the cell. Taken together, our data show that B. subtilis is a well-suited host for the molecular characterization of regulatory systems controlling resistance against cell wall active compounds in E. faecalis. Importantly, B. subtilis facilitates the careful adjustment of expression levels and genetic background required for full functionality of the introduced regulators.

LASER APPLICATIONS AND OTHER TOPICS IN QUANTUM ELECTRONICS: Application of the Wigner function and matrix optics to describe variations in the shape of ultrashort laser pulses propagating through linear optical systems

NASA Astrophysics Data System (ADS)

Gitin, Andrey V.

2006-04-01

The transformation of the shape of ultrashort laser pulses (USPs) in time can be described similarly to the process of image formation in space. It is shown that the wave description of imaging is simplified by using the Wigner function, this description in the quadratic approximation being identical to the use of the ABCD matrices. The transformation of USPs propagating through linear optical systems was described and these systems were classified by the methods of matrix optics.

Two kinds of Airy-related beams

NASA Astrophysics Data System (ADS)

Xu, Yiqing; Zhou, Guoquan; Zhang, Lijun; Ru, Guoyun

2015-08-01

Two kinds of Airy-related beams are introduced in this manuscript. The normalized intensity distribution in the x-direction of the two kinds of Airy-related beams is close to that of the Gaussian beam. The normalized intensity distribution in the y-direction of the two kinds of Airy-related beams is close to that of the second-order and the third-order elegant Hermite-Gaussian beams, respectively. Analytical expressions of the two kinds of Airy-related beams passing through an ABCD paraxial optical system are derived. The beam propagation factors for the two kinds of Airy-related beams are 1.933 and 2.125, respectively. Analytical expressions of the beam half widths and the kurtosis parameters of the two kinds of Airy-related beams passing through an ABCD paraxial optical system are also presented. As a numerical example, the propagation properties of the two kinds of Airy-related beams are demonstrated in free space. Moreover, the comparison between the two kinds of Airy-related beams and their corresponding elegant Hermite-Gaussian beams along the two transverse directions are performed in detail. Upon propagation, the former kind of Airy-related beam will evolve from the central bright beam into the dark hollow beam. Contrarily, the latter kind of Airy-related beam will evolve from the dark hollow beam into the central bright beam. These two kinds of Airy-related beams can be used to describe specially distributed beams.

Elegant Hermite-Airy beams

NASA Astrophysics Data System (ADS)

Zhou, Guoquan; Zhang, Lijun; Ru, Guoyun

2015-09-01

As Ai(x)Ai(-x) can be approximated by \\text{exp}≤ft(-{{x}2}/2\\right) , a kind of elegant Hermite-Airy (EHA) beam that is similar to the elegant Hermite-Gaussian (EHG) beam is introduced in this paper. Analytical expression of the EHA beams passing through an ABCD paraxial optical system is derived. By using the method of numerical fitting, the approximate expressions of 02> , 04> , <\\Thetaj2> , <\\Thetaj4> , and 02\\Thetaj2> for an EHA beam are presented, respectively. When the transverse mode number is larger than 2, 02> , 04> , <\\Thetaj2> , <\\Thetaj4> , and 02\\Thetaj2> of an EHA beam are all larger than those of the EHG beam. Based on the higher-order intensity moments, one can calculate the beam propagation factor, the beam half width, and the kurtosis parameter of the EHA beam passing through an ABCD paraxial optical system. As a numerical example, the propagation characteristics of the EHA beam are demonstrated in free space. Moreover, the propagation properties of the EHA beam are compared with those of the corresponding EHG beam. The evolutionary process of the EHA beam is far slower than that of the corresponding EHG beam. The research denotes that the EHA beams can be used to describe specially distributed optical beams that can not be characterized by the existing EHG beam model. The EHA beam model enriches and replenishes the existing beam model.

Double-bosonization and Majid's conjecture, (I): Rank-inductions of ABCD

NASA Astrophysics Data System (ADS)

Hu, Hongmei; Hu, Naihong

2015-11-01

Majid developed in [S. Majid, Math. Proc. Cambridge Philos. Soc. 125, 151-192 (1999)] the double-bosonization theory to construct Uq(𝔤) and expected to generate inductively not just a line but a tree of quantum groups starting from a node. In this paper, the authors confirm Majid's first expectation (see p. 178 [S. Majid, Math. Proc. Cambridge Philos. Soc. 125, 151-192 (1999)]) through giving and verifying the full details of the inductive constructions of Uq(𝔤) for the classical types, i.e., the ABCD series. Some examples in low ranks are given to elucidate that any quantum group of classical type can be constructed from the node corresponding to Uq(𝔰𝔩2).

Characterization of Acinetobacter baumannii biofilm associated components

NASA Astrophysics Data System (ADS)

Brossard, Kari A.

Acinetobacter baumannii is a Gram-negative aerobic coccobaccillus that is a major cause of nosocomial infections worldwide. Infected individuals may develop pneumonia, urinary tract, wound, and other infections that are associated with the use of indwelling medical devices such as catheters and mechanical ventilation. Treatment is difficult because many A. baumannii isolates have developed multi-drug resistance and the bacterium can persist on abiotic surfaces. Persistence and resistance may be due to formation of biofilms, which leads to long-term colonization, evasion of the host immune system and resistance to treatment with antibiotics and disinfectants. While biofilms are complex multifaceted structures, two bacterial components that have been shown to be important in formation and stability are exopolysaccharides (EPS) and the biofilm-associated protein (Bap). An EPS, poly-beta-1,6-N-acetylglucosamine, PNAG, has been described for E. coli and S. epidermidis. PNAG acts as an intercellular adhesin. Production of this adhesin is dependent on the pga/icaABCD locus. We have identified a homologous locus in A. baumannii 307-0294 that is involved in production of an exopolysaccharide, recognized by an anti-PNAG antibody. We hypothesized that the A. baumannii pgaABCD locus plays a role in biofilm formation, and protection against host innate defenses and disinfectants suggesting that PNAG is a possible virulence factor for the organism. The first aim of this thesis will define the pgaABCD locus. We have previously identified Bap, a protein with similarity to those described for S. aureus and we have demonstrated that this protein is involved in maintaining the stability of biofilms on glass. We hypothesized that A. baumannii Bap plays a role in persistence and pathogenesis and is regulated by quorum sensing. In our second aim we will examine the role of Bap in attachment and biofilm formation on medically relevant surfaces and also determine if Bap is involved in epithelial cell surface attachment and invasion. Finally we will determine the effects of quorum sensing on the expression of Bap.

Identification and Classification of bcl Genes and Proteins of Bacillus cereus Group Organisms and Their Application in Bacillus anthracis Detection and Fingerprinting▿ †

PubMed Central

Leski, Tomasz A.; Caswell, Clayton C.; Pawlowski, Marcin; Klinke, David J.; Bujnicki, Janusz M.; Hart, Sean J.; Lukomski, Slawomir

2009-01-01

The Bacillus cereus group includes three closely related species, B. anthracis, B. cereus, and B. thuringiensis, which form a highly homogeneous subdivision of the genus Bacillus. One of these species, B. anthracis, has been identified as one of the most probable bacterial biowarfare agents. Here, we evaluate the sequence and length polymorphisms of the Bacillus collagen-like protein bcl genes as a basis for B. anthracis detection and fingerprinting. Five genes, designated bclA to bclE, are present in B. anthracis strains. Examination of bclABCDE sequences identified polymorphisms in bclB alleles of the B. cereus group organisms. These sequence polymorphisms allowed specific detection of B. anthracis strains by PCR using both genomic DNA and purified Bacillus spores in reactions. By exploiting the length variation of the bcl alleles it was demonstrated that the combined bclABCDE PCR products generate markedly different fingerprints for the B. anthracis Ames and Sterne strains. Moreover, we predict that bclABCDE length polymorphism creates unique signatures for B. anthracis strains, which facilitates identification of strains with specificity and confidence. Thus, we present a new diagnostic concept for B. anthracis detection and fingerprinting, which can be used alone or in combination with previously established typing platforms. PMID:19767469

The pgaABCD Locus of Escherichia coli Promotes the Synthesis of a Polysaccharide Adhesin Required for Biofilm Formation

PubMed Central

Wang, Xin; Preston, James F.; Romeo, Tony

2004-01-01

Production of a polysaccharide matrix is a hallmark of bacterial biofilms, but the composition of matrix polysaccharides and their functions are not widely understood. Previous studies of the regulation of Escherichia coli biofilm formation suggested the involvement of an unknown adhesin. We now establish that the pgaABCD (formerly ycdSRQP) locus affects biofilm development by promoting abiotic surface binding and intercellular adhesion. All of the pga genes are required for optimal biofilm formation under a variety of growth conditions. A pga-dependent cell-bound polysaccharide was isolated and determined by nuclear magnetic resonance analyses to consist of unbranched β-1,6-N-acetyl-d-glucosamine, a polymer previously unknown from the gram-negative bacteria but involved in adhesion by staphylococci. The pga genes are predicted to encode envelope proteins involved in synthesis, translocation, and possibly surface docking of this polysaccharide. As predicted, if poly-β-1,6-GlcNAc (PGA) mediates cohesion, metaperiodate caused biofilm dispersal and the release of intact cells, whereas treatment with protease or other lytic enzymes had no effect. The pgaABCD operon exhibits features of a horizontally transferred locus and is present in a variety of eubacteria. Therefore, we propose that PGA serves as an adhesin that stabilizes biofilms of E. coli and other bacteria. PMID:15090514

A New Black Carbon Sensor for Dense Air Quality Monitoring Networks

PubMed Central

Caubel, Julien J.; Cados, Troy E.; Kirchstetter, Thomas W.

2018-01-01

Low-cost air pollution sensors are emerging and increasingly being deployed in densely distributed wireless networks that provide more spatial resolution than is typical in traditional monitoring of ambient air quality. However, a low-cost option to measure black carbon (BC)—a major component of particulate matter pollution associated with adverse human health risks—is missing. This paper presents a new BC sensor designed to fill this gap, the Aerosol Black Carbon Detector (ABCD), which incorporates a compact weatherproof enclosure, solar-powered rechargeable battery, and cellular communication to enable long-term, remote operation. This paper also demonstrates a data processing methodology that reduces the ABCD’s sensitivity to ambient temperature fluctuations, and therefore improves measurement performance in unconditioned operating environments (e.g., outdoors). A fleet of over 100 ABCDs was operated outdoors in collocation with a commercial BC instrument (Magee Scientific, Model AE33) housed inside a regulatory air quality monitoring station. The measurement performance of the 105 ABCDs is comparable to the AE33. The fleet-average precision and accuracy, expressed in terms of mean absolute percentage error, are 9.2 ± 0.8% (relative to the fleet average data) and 24.6 ± 0.9% (relative to the AE33 data), respectively (fleet-average ± 90% confidence interval). PMID:29494528

Evaluation of pharmacological induction of fatty acid beta-oxidation in X-linked adrenoleukodystrophy.

PubMed

McGuinness, M C; Zhang, H P; Smith, K D

2001-01-01

X-linked adrenoleukodystrophy (X-ALD) is an inherited neurometabolic disorder associated with elevated levels of saturated unbranched very-long-chain fatty acids (VLCFA; C > 22:0) in plasma and tissues, and reduced VLCFA beta-oxidation in fibroblasts, white blood cells, and amniocytes from X-ALD patients. The X-ALD gene (ABCD1) at Xq28 encodes the adrenoleukodystrophy protein (ALDP) that is related to the peroxisomal ATP-binding cassette (ABCD) transmembrane half-transporter proteins. The function of ALDP is unknown and its role in VLCFA accumulation unresolved. Previously, our laboratory has shown that sodium 4-phenylbutyrate (4PBA) treatment of X-ALD fibroblasts results in increased peroxisomal VLCFA beta-oxidation activity and increased expression of the X-ALD-related protein, ALDRP, encoded by the ABCD2 gene. In this study, the effect of various pharmacological agents on VLCFA beta-oxidation in ALD mouse fibroblasts is tested. 4PBA, styrylacetate and benzyloxyacetate (structurally related to 4PBA), and trichostatin A (functionally related to 4PBA) increase both VLCFA (peroxisomal) and long-chain fatty acid [LCFA (peroxisomal and mitochondrial)] beta-oxidation. Isobutyrate, zaprinast, hydroxyurea, and 5-azacytidine had no effect on VLCFA or LCFA beta-oxidation. Lovastatin had no effect on fatty acid beta-oxidation under normal tissue culture conditions but did result in an increase in both VLCFA and LCFA beta-oxidation when ALD mouse fibroblasts were cultured in the absence of cholesterol. The effect of trichostatin A on peroxisomal VLCFA beta-oxidation is shown to be independent of an increase in ALDRP expression, suggesting that correction of the biochemical abnormality in X-ALD is not dependent on pharmacological induction of a redundant gene (ABCD2). These studies contribute to a better understanding of the role of ALDP in VLCFA accumulation and may lead to the development of more effective pharmacological therapies. Copyright 2001 Academic Press.

ADIPOSITY-BASED CHRONIC DISEASE AS A NEW DIAGNOSTIC TERM: THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY POSITION STATEMENT.

PubMed

Mechanick, Jeffrey I; Hurley, Daniel L; Garvey, W Timothy

2017-03-01

The American Association of Clinical Endocrinologists (AACE) and American College of Endocrinology (ACE) have created a chronic care model, advanced diagnostic framework, clinical practice guidelines, and clinical practice algorithm for the comprehensive management of obesity. This coordinated effort is not solely based on body mass index as in previous models, but emphasizes a complications-centric approach that primarily determines therapeutic decisions and desired outcomes. Adiposity-Based Chronic Disease (ABCD) is a new diagnostic term for obesity that explicitly identifies a chronic disease, alludes to a precise pathophysiologic basis, and avoids the stigmata and confusion related to the differential use and multiple meanings of the term "obesity." Key elements to further the care of patients using this new ABCD term are: (1) positioning lifestyle medicine in the promotion of overall health, not only as the first algorithmic step, but as the central, pervasive action; (2) standardizing protocols that comprehensively and durably address weight loss and management of adiposity-based complications; (3) approaching patient care through contextualization (e.g., primordial prevention to decrease obesogenic environmental risk factors and transculturalization to adapt evidence-based recommendations for different ethnicities, cultures, and socio-economics); and lastly, (4) developing evidence-based strategies for successful implementation, monitoring, and optimization of patient care over time. This AACE/ACE blueprint extends current work and aspires to meaningfully improve both individual and population health by presenting a new ABCD term for medical diagnostic purposes, use in a complications-centric management and staging strategy, and precise reference to the obesity chronic disease state, divested from counterproductive stigmata and ambiguities found in the general public sphere. AACE = American Association of Clinical Endocrinologists ABCD = Adiposity-Based Chronic Disease ACE = American College of Endocrinology BMI = body mass index CPG = clinical practice guidelines HCP = health care professionals.

TECHNICAL ASPECTS OF LAPAROSCOPIC SLEEVE GASTRECTOMY

PubMed Central

RAMOS, Almino Cardoso; BASTOS, Eduardo Lemos de Souza; RAMOS, Manoela Galvão; BERTIN, Nestor Tadashi Suguitani; GALVÃO, Thales Delmondes; de LUCENA, Raphael Torres Figueiredo; CAMPOS, Josemberg Marins

2015-01-01

Background : The vertical gastrectomy indications for surgical treatment of morbid obesity have increased worldwide. Despite this increase, many aspects of surgical technique still remains in controversy. Aim : To contribute presenting surgical details in order to better realize the vertical gastrectomy technique in bariatric surgery. Methods : Technical systematization, patient preparation, positioning of the trocars, operative technique and postoperative care are presented in details. Results : During 12 months were enrolled 120 patients undergoing GV according to the technique described herein. The results are published in another ABCD article (ABCD 2015;28(Supl.1):61-64) in this same volume and number. Conclusion : The surgical technique proposed here presented itself viable and facilitating the surgeon's work on difficult points of the vertical gastrectomy. PMID:26537278

The Cation-Responsive Protein NhaR of Escherichia coli Activates pgaABCD Transcription, Required for Production of the Biofilm Adhesin Poly-β-1,6-N-Acetyl-d-Glucosamine▿

PubMed Central

Goller, Carlos; Wang, Xin; Itoh, Yoshikane; Romeo, Tony

2006-01-01

The pgaABCD operon of Escherichia coli is required for production of the biofilm adhesin poly-β-1,6-N-acetyl-d-glucosamine (PGA). We establish here that NhaR, a DNA-binding protein of the LysR family of transcriptional regulators, activates transcription of this operon. Disruption of the nhaR gene decreased biofilm formation without affecting planktonic growth. PGA production was undetectable in an nhaR mutant strain. Expression of a pgaA′-′lacZ translational fusion was induced by NaCl and alkaline pH, but not by CaCl2 or sucrose, in an nhaR-dependent fashion. Primer extension and quantitative real-time reverse transcription-PCR analyses further revealed that NhaR affects the steady-state level of pga mRNA. A purified recombinant NhaR protein bound specifically and with high affinity within the pgaABCD promoter region; one apparent binding site overlaps the −35 element, and a second site lies immediately upstream of the first. This protein was necessary and sufficient for activation of in vitro transcription from the pgaA promoter. These results define a novel mechanism for regulation of biofilm formation in response to environmental conditions and suggest an expanded role for NhaR in promoting bacterial survival. PMID:16997959

Lactose metabolism by Staphylococcus aureus: characterization of lacABCD, the structural genes of the tagatose 6-phosphate pathway.

PubMed Central

Rosey, E L; Oskouian, B; Stewart, G C

1991-01-01

The nucleotide and deduced amino acid sequences of the lacA and lacB genes of the Staphylococcus aureus lactose operon (lacABCDFEG) are presented. The primary translation products are polypeptides of 142 (Mr = 15,425) and 171 (Mr = 18,953) amino acids, respectively. The lacABCD loci were shown to encode enzymes of the tagatose 6-phosphate pathway through both in vitro studies and complementation analysis in Escherichia coli. A serum aldolase assay, modified to allow detection of the tagatose 6-phosphate pathway enzymes utilizing galactose 6-phosphate or fructose phosphate analogs as substrate, is described. Expression of both lacA and lacB was required for galactose 6-phosphate isomerase activity. LacC (34 kDa) demonstrated tagatose 6-phosphate kinase activity and was found to share significant homology with LacC from Lactococcus lactis and with both the minor 6-phosphofructokinase (PfkB) and 1-phosphofructokinase (FruK) from E. coli. Detection of tagatose 1,6-bisphosphate aldolase activity was dependent on expression of the 36-kDa protein specified by lacD. The LacD protein is highly homologous with LacD of L. lactis. Thus, the lacABCD genes comprise the tagatose 6-phosphate pathway and are cotranscribed with genes lacFEG, which specify proteins for transport and cleavage of lactose in S. aureus. PMID:1655695

On the treatment of evapotranspiration, soil moisture accounting, and aquifer recharge in monthly water balance models

USGS Publications Warehouse

Alley, William M.

1984-01-01

Several two- to six-parameter regional water balance models are examined by using 50-year records of monthly streamflow at 10 sites in New Jersey. These models include variants of the Thornthwaite-Mather model, the Palmer model, and the more recent Thomas abcd model. Prediction errors are relatively similar among the models. However, simulated values of state variables such as soil moisture storage differ substantially among the models, and fitted parameter values for different models sometimes indicated an entirely different type of basin response to precipitation. Some problems in parameter identification are noted, including difficulties in identifying an appropriate time lag factor for the Thornthwaite-Mather-type model for basins with little groundwater storage, very high correlations between upper and lower storages in the Palmer-type model, and large sensitivity of parameter a of the abcd model to bias in estimates of precipitation and potential evapotranspiration. Modifications to the threshold concept of the Thornthwaite-Mather model were statistically valid for the six stations in northern New Jersey. The abcd model resulted in a simulated seasonal cycle of groundwater levels similar to fluctuations observed in nearby wells but with greater persistence. These results suggest that extreme caution should be used in attaching physical significance to model parameters and in using the state variables of the models in indices of drought and basin productivity.

Decision-making deficits in pathological gambling: the role of executive functions, explicit knowledge and impulsivity in relation to decisions made under ambiguity and risk.

PubMed

Ochoa, Cristian; Alvarez-Moya, Eva M; Penelo, Eva; Aymami, M Neus; Gómez-Peña, Mónica; Fernández-Aranda, Fernando; Granero, Roser; Vallejo-Ruiloba, Julio; Menchón, José Manuel; Lawrence, Natalia S; Jiménez-Murcia, Susana

2013-01-01

A variety of cognitive and emotional processes influence the decision-making deficits observed in pathological gambling (PG). This study investigated the role of immediate/delayed sensitivity to reward and punishment, executive functions, impulsivity and explicit knowledge in relation to decision-making performance on the original Iowa Gambling Task (IGT-ABCD) and a variant (IGT-EFGH). We assessed 131 consecutive patients with a diagnosis of PG by using executive functioning and decision-making tasks, self-report measures of impulsivity and explicit knowledge. The majority of pathological gamblers (PGs) showed deficits in decision-making, characterized mainly by myopia for the future. Decisions made under risk showed different predictors. Performance on the IGT-ABCD for decisions made under risk was predicted by medium and high levels of explicit knowledge of the task, as well as by scores on the Disorderliness subscale and the degree of Stroop interference. By contrast, IGT-EFGH results were only associated with self-report impulsivity measures. Decision making in PG involves distinct patterns of deficits, and the predictors differ depending on the reinforcement schedule. Decisions made under risk on the IGT-ABCD are associated with explicit knowledge, executive functions and impulsivity traits related to conscious awareness and control processes. On the IGT-EFGH, however, only impulsivity traits predict decision making. Copyright © American Academy of Addiction Psychiatry.

Myopia for the future or hypersensitivity to reward? Age-related changes in decision making on the Iowa Gambling Task.

PubMed

Bauer, A S; Timpe, J; Edmonds, E C; Bechara, A; Tranel, D; Denburg, N L

2013-02-01

It has been shown that older adults perform less well than younger adults on the Iowa Gambling Task (IGT), a real-world type decision-making task that factors together reward, punishment, and uncertainty. To explore the reasons behind this age-related decrement, we administered to an adult life span sample of 265 healthy participants (Mdn age = 62.00 +/- 16.17 years; range [23-88]) 2 versions of the IGT, which have different contingencies for successful performance: A'B'C'D' requires choosing lower immediate reward (paired with lower delayed punishment); E'F'G'H' requires choosing higher immediate punishment (paired with higher delayed reward). There was a significant negative correlation between age and performance on the A'B'C'D' version of the IGT (r = -.16, p = .01), while there was essentially no correlation between age and performance on the E'F'G'H' version (r = -.07, p = .24). In addition, the rate of impaired performance in older participants was significantly higher for the A'B'C'D' version (23%) compared with the E'F'G'H' version (13%). A parsimonious account of these findings is an age-related increase in hypersensitivity to reward, whereby the decisions of older adults are disproportionately influenced by prospects of receiving reward, irrespective of the presence or degree of punishment. PsycINFO Database Record (c) 2013 APA, all rights reserved.

Tool to Distinguish Moles from Melanoma

Cancer.gov

“Moles to Melanoma: Recognizing the ABCDE Features” presents photos that show changes in individual pigmented lesions over time, and describes the different appearances of moles, dysplastic nevi, and melanomas.

An alternative model for a partially coherent elliptical dark hollow beam

NASA Astrophysics Data System (ADS)

Li, Xu; Wang, Fei; Cai, Yangjian

2011-04-01

An alternative theoretical model named partially coherent hollow elliptical Gaussian beam (HEGB) is proposed to describe a partially coherent beam with an elliptical dark hollow profile. Explicit expression for the propagation factors of a partially coherent HEGB is derived. Based on the generalized Collins formula, analytical formulae for the cross-spectral density and mean-squared beam width of a partially coherent HEGB, propagating through a paraxial ABCD optical system, are derived. Propagation properties of a partially coherent HEGB in free space are studied as a numerical example.

Convergent evolution of Amadori opine catabolic systems in plasmids of Agrobacterium tumefaciens.

PubMed

Baek, Chang-Ho; Farrand, Stephen K; Lee, Ko-Eun; Park, Dae-Kyun; Lee, Jeong Kug; Kim, Kun-Soo

2003-01-01

Deoxyfructosyl glutamine (DFG, referred to elsewhere as dfg) is a naturally occurring Amadori compound found in rotting fruits and vegetables. DFG also is an opine and is found in tumors induced by chrysopine-type strains of Agrobacterium tumefaciens. Such strains catabolize this opine via a pathway coded for by their plasmids. NT1, a derivative of the nopaline-type A. tumefaciens strain C58 lacking pTiC58, can utilize DFG as the sole carbon source. Genes for utilization of DFG were mapped to the 543-kb accessory plasmid pAtC58. Two cosmid clones of pAtC58 allowed UIA5, a plasmid-free derivative of C58, harboring pSa-C that expresses MocC (mannopine [MOP] oxidoreductase that oxidizes MOP to DFG), to grow by using MOP as the sole carbon source. Genetic analysis of subclones indicated that the genes for utilization of DFG are located in a 6.2-kb BglII (Bg2) region adjacent to repABC-type genes probably responsible for the replication of pAtC58. This region contains five open reading frames organized into at least two transcriptional soc (santhopine catabolism) groups: socR and socABCD. Nucleotide sequence analysis and analyses of transposon-insertion mutations in the region showed that SocR negatively regulates the expression of socR itself and socABCD. SocA and SocB are responsible for transport of DFG and MOP. SocA is a homolog of known periplasmic amino acid binding proteins. The N-terminal half of SocB is a homolog of the transmembrane transporter proteins for several amino acids, and the C-terminal half is a homolog of the transporter-associated ATP-binding proteins. SocC and SocD could be responsible for the enzymatic degradation of DFG, being homologs of sugar oxidoreductases and an amadoriase from Corynebacterium sp., respectively. The protein products of socABCD are not related at the amino acid sequence level to those of the moc and mot genes of Ti plasmids responsible for utilization of DFG and MOP, indicating that these two sets of genes and their catabolic pathways have evolved convergently from independent origins.

Reconstitution of active mycobacterial binuclear iron monooxygenase complex in Escherichia coli.

PubMed

Furuya, Toshiki; Hayashi, Mika; Kino, Kuniki

2013-10-01

Bacterial binuclear iron monooxygenases play numerous physiological roles in oxidative metabolism. Monooxygenases of this type found in actinomycetes also catalyze various useful reactions and have attracted much attention as oxidation biocatalysts. However, difficulties in expressing these multicomponent monooxygenases in heterologous hosts, particularly in Escherichia coli, have hampered the development of engineered oxidation biocatalysts. Here, we describe a strategy to functionally express the mycobacterial binuclear iron monooxygenase MimABCD in Escherichia coli. Sodium dodecyl sulfate-polyacrylamide gel electrophoretic analysis of the mimABCD gene expression in E. coli revealed that the oxygenase components MimA and MimC were insoluble. Furthermore, although the reductase MimB was expressed at a low level in the soluble fraction of E. coli cells, a band corresponding to the coupling protein MimD was not evident. This situation rendered the transformed E. coli cells inactive. We found that the following factors are important for functional expression of MimABCD in E. coli: coexpression of the specific chaperonin MimG, which caused MimA and MimC to be soluble in E. coli cells, and the optimization of the mimD nucleotide sequence, which led to efficient expression of this gene product. These two remedies enabled this multicomponent monooxygenase to be actively expressed in E. coli. The strategy described here should be generally applicable to the E. coli expression of other actinomycetous binuclear iron monooxygenases and related enzymes and will accelerate the development of engineered oxidation biocatalysts for industrial processes.

The scale of the Fourier transform: a point of view of the fractional Fourier transform

NASA Astrophysics Data System (ADS)

Jimenez, C. J.; Vilardy, J. M.; Salinas, S.; Mattos, L.; Torres, C. O.

2017-01-01

In this paper using the Fourier transform of order fractional, the ray transfer matrix for the symmetrical optical systems type ABCD and the formulae by Collins for the diffraction, we obtain explicitly the expression for scaled Fourier transform conventional; this result is the great importance in optical signal processing because it offers the possibility of scaling the size of output the Fourier distribution of the system, only by manipulating the distance of the diffraction object toward the thin lens, this research also emphasizes on practical limits when a finite spherical converging lens aperture is used. Digital simulation was carried out using the numerical platform of Matlab 7.1.

Methods for Factor Screening in Computer Simulation Experiments

DTIC Science & Technology

1979-03-01

are generally of two types: 1. Factors that are centrollable or subject to de .-ign in the "real world" system being modeled, such as inventory...62! La 2j L -2 J The least squares estimates of the parameters become o0[30.50 4.50 K2 15.50 06121 -0.50 From examining the estimates of the effects...BDF ACDEF F ACD BDE ABCEF AB CE BCDF ADEF AC BE DF ABCDEF AD CF BCDE ABDF AE BC CDEF ABPE A? CD BCEF ABDE BD E.F ACDE ABCF BF DE ABCD ACEF ABF CEP BCD

Theoretical study on phase-locking of a radial array CO2 laser

NASA Astrophysics Data System (ADS)

Xu, Yonggen

2014-11-01

The phase-locking of the radial array CO2 laser (RAL) is introduced based on the injection-locking principle. The characteristic parameters of laser beams used in the phase-locking are described, and the coupling coefficient c00 between the injected mode and the eigenmode of RAL is calculated. The laser modes from RAL are the low-order Hermite Gaussian modes due to the diffraction loss. The analytical formula for the output beam through an ABCD optical system is derived according Collins formula. The numerical examples are given to illustrate our analytical results.

ABCD classification system: a novel classification for subaxial cervical spine injuries.

PubMed

Shousha, Mootaz

2014-04-20

The classification system was derived through a retrospective analysis of 73 consecutive cases of subaxial cervical spine injury as well as thorough literature review. To define a new classification system for subaxial cervical spine injuries. There exist several methods to classify subaxial cervical spine injuries but no single system has emerged as clearly superior to the others. On the basis of a 2-column anatomical model, the first part of the proposed classification is an anatomical description of the injury. It delivers the information whether the injury is bony, ligamentous, or a combined one. The first 4 alphabetical letters have been used for simplicity. Each column is represented by an alphabetical letter from A to D. Each letter has a radiological meaning (A = Absent injury, B = Bony lesion, C = Combined bony and ligamentous, D = Disc or ligamentous injury).The second part of the classification is represented by 3 modifiers. These are the neurological status of the patient (N), the degree of spinal canal stenosis (S), and the degree of instability (I). For simplicity, each modifier was graded in an ascending pattern of severity from zero to 2. The last part is optional and denotes which radiological examination has been used to define the injury type. The new ABCD classification was applicable for all patients. The most common type was anterior ligamentous and posterior combined injury "DC" (37.9%), followed by "DD" injury in 12% of the cases. Through this work a new classification for cervical spine injuries is proposed. The aim is to establish criteria for a common language in description of cervical injuries aiming for simplification, especially for junior residents. Each letter and each sign has a meaning to deliver the largest amount of information. Both the radiological as well as the clinical data are represented in this scheme. However, further evaluation of this classification is needed. 3.

Decision-making performance of depressed patients within 72 h following a suicide attempt.

PubMed

Hegedűs, Klára M; Szkaliczki, Andrea; Gál, Bernadett I; Andó, Bálint; Janka, Zoltán; Álmos, Péter Z

2018-08-01

The significance of decision-making in suicidal behaviour is often highlighted; however, the performance of persons in suicide crisis is unknown. This study aimed to explore the comprehensive decision-making profile of depressed patients following a suicide attempt. Decision-making was measured by reward- ("ABCD") and punishment- ("EFGH") sensitive versions of the Iowa Gambling Task (IGT) in 59 medication-free depressed patients within 72 h after a suicide attempt and in 46 healthy control subjects. Severity of depressive symptoms was assessed in the patient group by the Hamilton Depression Rating Scale. Performance of the two groups differed significantly on the IGT ABCD, while a trend towards significant differences was seen on the IGT EFGH. Severity of depressive symptoms did not affect the depressed participants' decision-making performance. Subjects were not matched for years of education. Administration of the IGT ABCD and IGT EFGH was not counterbalanced. Methods of suicide attempts and history of previous attempts were not collected. Individuals with a recent suicide attempt showed decision-making dysfunction on both IGT versions. However, on the EFGH, the overall difference between groups was not significant, depressed participants' performance remained poor during all blocks. Their behaviour reflected a focus on best immediate possible outcomes, not regarding future adverse consequences. This could be a result of psychological and cognitive alterations which modulate suicidal behaviour independent from mood. Further longitudinal studies should verify this possibility. Investigation of state-dependent neuropsychological characteristics of suicidal behaviour might be essential for detecting acute suicidal crisis. Copyright © 2018 Elsevier B.V. All rights reserved.

Strategies for Improving Maintenance and Generalization of Academic Skills--So Students "Don't Leave Class without It."

ERIC Educational Resources Information Center

Gable, Robert A.; And Others

1992-01-01

An instructional process for facilitating maintenance and generalization of academic skills is presented, using the ABCD'S (Antecedent Events, Behavior, Consequent Events, Data, and Setting Events) Generalization Intervention Model. (JDD)

AB067. X-linked adrenoleukodystrophy: Phenotype and genotype in Vietnamese patients

PubMed Central

Nguyen, Khanh Ngoc; Nguyen, Ha Thu; Can, Ngoc Thi Bich; Bui, Thao Phuong; Nobuyuki, Shimozawa; Vu, Huynh Anh; Do, Mai Thi Thanh; Vu, Dung Chi

2017-01-01

Background X-linked adrenoleukodystrophy (X-ALD) is caused by a defect in the gene ABCD1, which maps to Xq28 and codes for a peroxisomal membrane protein that is a member of the ATP-binding cassette transporter superfamily. This disease characterized by progressive neurologic dysfunction, occasionally associated with adrenal insufficiency. Objective is to identify phenotype and genotype in Vietnamese patients with X-ALD. Methods Genomic DNA from 20 Vietnamese patients from 18 unrelated families was extracted using standard procedures from the peripheral blood leukocytes. Mutation analysis of ABCD1 was performed using polymerase chain reaction (PCR) and DNA direct sequencing. Results We identified 17 different mutations of ABCD1 in 20 patients including missense mutations (2/17), deletion (4/17), frameshift mutation (1/17) and splice site mutation (1/17). Of which, six novel mutations including c.1202G>T (p.Arg401Trp); c.1208T>A (p.Met403Lys); IVS8+28-551bp del; c.1668G>C (p.Q556H); c.292_296delTCGGC (p.S98RfsX95); and the extent of deletion included between IVS1+505 and IVS2+1501, containing whole the exon 2 (4243bp), plus insertion of 79bp from BAP31 and 8bp from unknown origin in this deleted region were identified in six unrelated patients. Eleven reported mutations including c.796G>A (p.Gly266Arg); c.1628C>T (p.Pro543Leu); c.1553G>A (p.Arg518Gln); c.1552 C>T (p.Arg518Trp); c.854G>C (p.R285P); c.1825G>A (p.E609K); c.1415_1416delAG (p.Q472RfsX83) and c.46-53del insG, c.1553G>A (p.Arg518Gln), c.1946-1947insA (p.Asp649fsX733), c.1978C>T (p.Arg660Trp) were identified in 14 patients from 12 families. Most of patients (17/20) presented cerebral ALD type with/without adrenal insufficiency and only 3 patients presented Addison type. Conclusions Mutation analysis of ABCD1 gene helped confirmation of diagnosis of X-ALD, genetic counselling and prenatal diagnosis but could not be used to predict the specific phenotype of X-ALD.

Amphotericin B formulations: a comparative review of efficacy and toxicity.

PubMed

Hamill, Richard J

2013-06-01

Because of the increasing prevalence and changing microbiological spectrum of invasive fungal infections, some form of amphotericin B still provides the most reliable and broad spectrum therapeutic alternative. However, the use of amphotericin B deoxycholate is accompanied by dose-limited toxicities, most importantly, infusion-related reactions and nephrotoxicity. In an attempt to improve the therapeutic index of amphotericin B, three lipid-associated formulations were developed, including amphotericin B lipid complex (ABLC), liposomal amphotericin B (L-AmB), and amphotericin B colloidal dispersion (ABCD). The lipid composition of all three of these preparations differs considerably and contributes to substantially different pharmacokinetic parameters. ABLC is the largest of the lipid preparations. Because of its size, it is taken up rapidly by macrophages and becomes sequestered in tissues of the mononuclear phagocyte system such as the liver and spleen. Consequently, compared with the conventional formulation, it has lower circulating amphotericin B serum concentrations, reflected in a marked increase in volume of distribution and clearance. Lung levels are considerably higher than those achieved with other lipid-associated preparations. The recommended therapeutic dose of ABLC is 5 mg/kg/day. Because of its small size and negative charge, L-AmB avoids substantial recognition and uptake by the mononuclear phagocyte system. Therefore, a single dose of L-AmB results in a much higher peak plasma level (Cmax) than conventional amphotericin B deoxycholate and a much larger area under the concentration-time curve. Tissue concentrations in patients receiving L-AmB tend to be highest in the liver and spleen and much lower in kidneys and lung. Recommended therapeutic dosages are 3-6 mg/kg/day. After intravenous infusion, ABCD complexes remain largely intact and are rapidly removed from the circulation by cells of the macrophage phagocyte system. On a milligram-to-milligram basis, the Cmax achieved is lower than that attained by conventional amphotericin B, although the larger doses of ABCD that are administered produce an absolute level that is similar to amphotericin B. ABCD exhibits dose-limiting, infusion-related toxicities; consequently, the administered dosages should not exceed 3-4 mg/kg/day. The few comparative clinical trials that have been completed with the lipid-associated formulations have not demonstrated important clinical differences among these agents and amphotericin B for efficacy, although there are significant safety benefits of the lipid products. Furthermore, only one published trial has ever compared one lipid product against another for any indication. The results of these trials are particularly difficult to interpret because of major heterogeneities in study design, disease definitions, drug dosages, differences in clinical and microbiological endpoints as well as specific outcomes examined. Nevertheless, it is possible to derive some general conclusions given the available data. The most commonly studied syndrome has been empiric therapy for febrile neutropenic patients, where the lipid-associated preparations did not appear to provide a survival benefit over conventional amphotericin B deoxycholate, but did offer a significant advantage for the prevention of various breakthrough invasive fungal infections. For treatment of documented invasive fungal infections that usually involved hematological malignancy patients, no individual randomized trial has demonstrated a mortality benefit due to therapy with one of the lipid formulations. Results from meta-analyses have been contradictory, with one demonstrating a mortality benefit from all-cause mortality and one that did not demonstrate a mortality benefit. In the only published study to examine HIV-infected patients with disseminated histoplasmosis, clinical success and mortality were significantly better with L-AmB compared with amphotericin B deoxycholate; there were no differences in microbiological outcomes between treatment groups. The lipid-associated preparations were not significantly better than amphotericin B deoxycholate for treatment of AIDS-associated acute cryptococcal meningitis for either clinical or microbiological outcomes that were studied. In all of the trials that specifically examined renal toxicity, the lipid-associated formulations were significantly less nephrotoxic than amphotericin B deoxycholate. Infusion-related reactions occurred less frequently with L-AmB when compared with amphotericin B deoxycholate; however, ABCD had equivalent or more frequent infusion-related reactions than conventional amphotericin B, and this resulted in the cessation of at least one clinical trial. At the present time, this particular lipid formulation is no longer commercially available. For the treatment of most invasive fungal infections, an amphotericin B lipid formulation provides a safer alternative than conventional amphotericin B, with at least equivalent efficacy. As the cost of therapy with these agents continues to decline, these drugs will likely maintain their important role in the antifungal drug armamentarium because of their efficacy and improved safety profile.

Convergent Evolution of Amadori Opine Catabolic Systems in Plasmids of Agrobacterium tumefaciens

PubMed Central

Baek, Chang-Ho; Farrand, Stephen K.; Lee, Ko-Eun; Park, Dae-Kyun; Lee, Jeong Kug; Kim, Kun-Soo

2003-01-01

Deoxyfructosyl glutamine (DFG, referred to elsewhere as dfg) is a naturally occurring Amadori compound found in rotting fruits and vegetables. DFG also is an opine and is found in tumors induced by chrysopine-type strains of Agrobacterium tumefaciens. Such strains catabolize this opine via a pathway coded for by their plasmids. NT1, a derivative of the nopaline-type A. tumefaciens strain C58 lacking pTiC58, can utilize DFG as the sole carbon source. Genes for utilization of DFG were mapped to the 543-kb accessory plasmid pAtC58. Two cosmid clones of pAtC58 allowed UIA5, a plasmid-free derivative of C58, harboring pSa-C that expresses MocC (mannopine [MOP] oxidoreductase that oxidizes MOP to DFG), to grow by using MOP as the sole carbon source. Genetic analysis of subclones indicated that the genes for utilization of DFG are located in a 6.2-kb BglII (Bg2) region adjacent to repABC-type genes probably responsible for the replication of pAtC58. This region contains five open reading frames organized into at least two transcriptional soc (santhopine catabolism) groups: socR and socABCD. Nucleotide sequence analysis and analyses of transposon-insertion mutations in the region showed that SocR negatively regulates the expression of socR itself and socABCD. SocA and SocB are responsible for transport of DFG and MOP. SocA is a homolog of known periplasmic amino acid binding proteins. The N-terminal half of SocB is a homolog of the transmembrane transporter proteins for several amino acids, and the C-terminal half is a homolog of the transporter-associated ATP-binding proteins. SocC and SocD could be responsible for the enzymatic degradation of DFG, being homologs of sugar oxidoreductases and an amadoriase from Corynebacterium sp., respectively. The protein products of socABCD are not related at the amino acid sequence level to those of the moc and mot genes of Ti plasmids responsible for utilization of DFG and MOP, indicating that these two sets of genes and their catabolic pathways have evolved convergently from independent origins. PMID:12511498

An alternative theoretical model for an anomalous hollow beam.

PubMed

Cai, Yangjian; Wang, Zhaoying; Lin, Qiang

2008-09-15

An alternative and convenient theoretical model is proposed to describe a flexible anomalous hollow beam of elliptical symmetry with an elliptical solid core, which was observed in experiment recently (Phys. Rev. Lett, 94 (2005) 134802). In this model, the electric field of anomalous hollow beam is expressed as a finite sum of elliptical Gaussian modes. Flattopped beams, dark hollow beams and Gaussian beams are special cases of our model. Analytical propagation formulae for coherent and partially coherent anomalous hollow beams passing through astigmatic ABCD optical systems are derived. Some numerical examples are calculated to show the propagation and focusing properties of coherent and partially coherent anomalous hollow beams.

A closed form of a kurtosis parameter of a hypergeometric-Gaussian type-II beam

NASA Astrophysics Data System (ADS)

F, Khannous; A, A. A. Ebrahim; A, Belafhal

2016-04-01

Based on the irradiance moment definition and the analytical expression of waveform propagation for hypergeometric-Gaussian type-II beams passing through an ABCD system, the kurtosis parameter is derived analytically and illustrated numerically. The kurtosis parameters of the Gaussian beam, modified Bessel modulated Gaussian beam with quadrature radial and elegant Laguerre-Gaussian beams are obtained by treating them as special cases of the present treatment. The obtained results show that the kurtosis parameter depends on the change of the beam order m and the hollowness parameter p, such as its decrease with increasing m and increase with increasing p.

Protective Effects of α-Tocopherol, γ-Tocopherol and Oleic Acid, Three Compounds of Olive Oils, and No Effect of Trolox, on 7-Ketocholesterol-Induced Mitochondrial and Peroxisomal Dysfunction in Microglial BV-2 Cells.

PubMed

Debbabi, Meryam; Nury, Thomas; Zarrouk, Amira; Mekahli, Nadia; Bezine, Maryem; Sghaier, Randa; Grégoire, Stéphane; Martine, Lucy; Durand, Philippe; Camus, Emmanuelle; Vejux, Anne; Jabrane, Aymen; Bretillon, Lionel; Prost, Michel; Moreau, Thibault; Ammou, Sofien Ben; Hammami, Mohamed; Lizard, Gérard

2016-11-25

Lipid peroxidation products, such as 7-ketocholesterol (7KC), may be increased in the body fluids and tissues of patients with neurodegenerative diseases and trigger microglial dysfunction involved in neurodegeneration. It is therefore important to identify synthetic and natural molecules able to impair the toxic effects of 7KC. We determined the impact of 7KC on murine microglial BV-2 cells, especially its ability to trigger mitochondrial and peroxisomal dysfunction, and evaluated the protective effects of α- and γ-tocopherol, Trolox, and oleic acid (OA). Multiple complementary chemical assays, flow cytometric and biochemical methods were used to evaluate the antioxidant and cytoprotective properties of these molecules. According to various complementary assays to estimate antioxidant activity, only α-, and γ-tocopherol, and Trolox had antioxidant properties. However, only α-tocopherol, γ-tocopherol and OA were able to impair 7KC-induced loss of mitochondrial transmembrane potential, which is associated with increased permeability to propidium iodide, an indicator of cell death. In addition, α-and γ-tocopherol, and OA were able to prevent the decrease in Abcd3 protein levels, which allows the measurement of peroxisomal mass, and in mRNA levels of Abcd1 and Abcd2, which encode for two transporters involved in peroxisomal β-oxidation. Thus, 7KC-induced side effects are associated with mitochondrial and peroxisomal dysfunction which can be inversed by natural compounds, thus supporting the hypothesis that the composition of the diet can act on the function of organelles involved in neurodegenerative diseases.

Diagnosing malignant melanoma in ambulatory care: a systematic review of clinical prediction rules

PubMed Central

Harrington, Emma; Clyne, Barbara; Wesseling, Nieneke; Sandhu, Harkiran; Armstrong, Laura; Bennett, Holly; Fahey, Tom

2017-01-01

Objectives Malignant melanoma has high morbidity and mortality rates. Early diagnosis improves prognosis. Clinical prediction rules (CPRs) can be used to stratify patients with symptoms of suspected malignant melanoma to improve early diagnosis. We conducted a systematic review of CPRs for melanoma diagnosis in ambulatory care. Design Systematic review. Data sources A comprehensive search of PubMed, EMBASE, PROSPERO, CINAHL, the Cochrane Library and SCOPUS was conducted in May 2015, using combinations of keywords and medical subject headings (MeSH) terms. Study selection and data extraction Studies deriving and validating, validating or assessing the impact of a CPR for predicting melanoma diagnosis in ambulatory care were included. Data extraction and methodological quality assessment were guided by the CHARMS checklist. Results From 16 334 studies reviewed, 51 were included, validating the performance of 24 unique CPRs. Three impact analysis studies were identified. Five studies were set in primary care. The most commonly evaluated CPRs were the ABCD, more than one or uneven distribution of Colour, or a large (greater than 6 mm) Diameter (ABCD) dermoscopy rule (at a cut-point of >4.75; 8 studies; pooled sensitivity 0.85, 95% CI 0.73 to 0.93, specificity 0.72, 95% CI 0.65 to 0.78) and the 7-point dermoscopy checklist (at a cut-point of ≥1 recommending ruling in melanoma; 11 studies; pooled sensitivity 0.77, 95% CI 0.61 to 0.88, specificity 0.80, 95% CI 0.59 to 0.92). The methodological quality of studies varied. Conclusions At their recommended cut-points, the ABCD dermoscopy rule is more useful for ruling out melanoma than the 7-point dermoscopy checklist. A focus on impact analysis will help translate melanoma risk prediction rules into useful tools for clinical practice. PMID:28264830

Efficacy of Sleeve Gastrectomy with Duodenal-Jejunal Bypass for the Treatment of Obese Severe Diabetes Patients in Japan: a Retrospective Multicenter Study.

PubMed

Naitoh, Takeshi; Kasama, Kazunori; Seki, Yosuke; Ohta, Masayuki; Oshiro, Takashi; Sasaki, Akira; Miyazaki, Yasuhiro; Yamaguchi, Tsuyoshi; Hayashi, Hideki; Imoto, Hirofumi; Tanaka, Naoki; Unno, Michiaki

2018-02-01

The incidence of obesity with type 2 diabetes (T2DM) is increasing in Japan. The main bariatric surgery procedures in Japan are laparoscopic sleeve gastrectomy (LSG) and LSG with duodenal-jejunal bypass (LSG/DJB) because of the high incidence of gastric cancer and difficulty exploring a remnant stomach after gastric bypass. However, few studies have compared the antidiabetic effect of LSG/DJB with LSG alone. The purpose of this study is to compare the antidiabetic effect of LSG/DJB with that of LSG alone in Japanese obese diabetic patients. This was a retrospective multicenter study including 298 cases: 177 and 121 LSG and LSG/DJB cases, respectively. We investigated the antidiabetic effect of these two procedures at 12 months after surgery. Univariate and multivariate analyses were done to evaluate the predictive factors of T2DM remission. The diabetes remission rate at 12 months after surgery was 80.8% for LSG and 86.0% for LSG/DJB. Insulin use and HbA1c ≤ 6.7% were significant predictive factors in multivariate analysis for all patients. In patients with ABCD score ≥ 6, the diabetes remission rate was 94.8% and there was no difference between procedures. Only duration of diabetes and insulin use were significant predictive factors both in univariate and multivariate analyses. However, in cases with ABCD score ≤ 5, the remission rate was 70.3% and procedure type was the most significant predictive factor for diabetes remission (odds ratio [OR] 5.140). Although both LSG and LSG/DJB have good antidiabetic effects in Japanese obese patients, LSG/DJB is more effective for patients with lower ABCD scores.

GOLD assessment of COPD severity in the Clinical Practice Research Datalink (CPRD).

PubMed

Rebordosa, Cristina; Plana, Estel; Aguado, Jaume; Thomas, Steven; García-Gil, Esther; Perez-Gutthann, Susana; Castellsague, Jordi

2018-05-08

To evaluate availability of spirometry and symptom data in the Clinical Practice Research Datalink (United Kingdom) to assess COPD severity using the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2016 definition and comparing it with an algorithm used in other studies. This was a descriptive, noninterventional, secondary database cohort study of patients with COPD aged 40 years or older, who initiated treatment with specific COPD medications. Patients were classified according to COPD severity (1) in GOLD 2016 "ABCD" categories based on symptoms (Medical Research Council dyspnea grade, COPD Assessment Test, breathlessness), percent predicted FEV1, and exacerbation history and (2) as mild, moderate, severe, or very severe based on treatment and exacerbation history. The study included 63 900 patients with COPD aged 40 years or older that were new users of 1 or more COPD medication of interest. Percent predicted FEV1 was available for 80.9% of patients; symptoms for 75.6% of patients. Classification into GOLD 2016 ABCD categories was possible for 75.6% of the patients. The GOLD 2016 ABCD definition classified more patients under the high-risk categories (22.1%, A; 18.8%, B; 21.3%, C; 37.9%, D) than did the adapted algorithm (7.9%, mild; 48.6%, moderate; 42.1%, severe; 1.4%, very severe). Using our adaptation of the GOLD 2016 COPD severity classification, the information in the Clinical Practice Research Datalink allowed us to ascertain COPD severity in approximately 75% of patients with COPD. Algorithms that include medication use tend to misclassify patients with the extreme COPD severity categories. Copyright © 2018 John Wiley & Sons, Ltd.

Impaired plasticity of macrophages in X-linked adrenoleukodystrophy.

PubMed

Weinhofer, Isabelle; Zierfuss, Bettina; Hametner, Simon; Wagner, Magdalena; Popitsch, Niko; Machacek, Christian; Bartolini, Barbara; Zlabinger, Gerhard; Ohradanova-Repic, Anna; Stockinger, Hannes; Köhler, Wolfgang; Höftberger, Romana; Regelsberger, Günther; Forss-Petter, Sonja; Lassmann, Hans; Berger, Johannes

2018-05-30

X-linked adrenoleukodystrophy is caused by ATP-binding cassette transporter D1 (ABCD1) mutations and manifests by default as slowly progressive spinal cord axonopathy with associated demyelination (adrenomyloneuropathy). In 60% of male cases, however, X-linked adrenoleukodystrophy converts to devastating cerebral inflammation and demyelination (cerebral adrenoleukodystrophy) with infiltrating blood-derived monocytes and macrophages and cytotoxic T cells that can only be stopped by allogeneic haematopoietic stem cell transplantation or gene therapy at an early stage of the disease. Recently, we identified monocytes/macrophages but not T cells to be severely affected metabolically by ABCD1 deficiency. Here we found by whole transcriptome analysis that, although monocytes of patients with X-linked adrenoleukodystrophy have normal capacity for macrophage differentiation and phagocytosis, they are pro-inflammatory skewed also in patients with adrenomyloneuropathy in the absence of cerebral inflammation. Following lipopolysaccharide activation, the ingestion of myelin debris, normally triggering anti-inflammatory polarization, did not fully reverse the pro-inflammatory status of X-linked adrenoleukodystrophy macrophages. Immunohistochemistry on post-mortem cerebral adrenoleukodystrophy lesions reflected the activation pattern by prominent presence of enlarged lipid-laden macrophages strongly positive for the pro-inflammatory marker co-stimulatory molecule CD86. Comparative analyses of lesions with matching macrophage density in cases of cerebral adrenoleukodystrophy and acute multiple sclerosis showed a similar extent of pro-inflammatory activation but a striking reduction of anti-inflammatory mannose receptor (CD206) and haemoglobin-haptoglobin receptor (CD163) expression on cerebral adrenoleukodystrophy macrophages. Accordingly, ABCD1-deficiency leads to an impaired plasticity of macrophages that is reflected in incomplete establishment of anti-inflammatory responses, thus possibly contributing to the devastating rapidly progressive demyelination in cerebral adrenoleukodystrophy that only in rare cases arrests spontaneously. These findings emphasize monocytes/macrophages as crucial therapeutic targets for preventing or stopping myelin destruction in patients with X-linked adrenoleukodystrophy.

Protective Effects of α-Tocopherol, γ-Tocopherol and Oleic Acid, Three Compounds of Olive Oils, and No Effect of Trolox, on 7-Ketocholesterol-Induced Mitochondrial and Peroxisomal Dysfunction in Microglial BV-2 Cells

PubMed Central

Debbabi, Meryam; Nury, Thomas; Zarrouk, Amira; Mekahli, Nadia; Bezine, Maryem; Sghaier, Randa; Grégoire, Stéphane; Martine, Lucy; Durand, Philippe; Camus, Emmanuelle; Vejux, Anne; Jabrane, Aymen; Bretillon, Lionel; Prost, Michel; Moreau, Thibault; Ammou, Sofien Ben; Hammami, Mohamed; Lizard, Gérard

2016-01-01

Lipid peroxidation products, such as 7-ketocholesterol (7KC), may be increased in the body fluids and tissues of patients with neurodegenerative diseases and trigger microglial dysfunction involved in neurodegeneration. It is therefore important to identify synthetic and natural molecules able to impair the toxic effects of 7KC. We determined the impact of 7KC on murine microglial BV-2 cells, especially its ability to trigger mitochondrial and peroxisomal dysfunction, and evaluated the protective effects of α- and γ-tocopherol, Trolox, and oleic acid (OA). Multiple complementary chemical assays, flow cytometric and biochemical methods were used to evaluate the antioxidant and cytoprotective properties of these molecules. According to various complementary assays to estimate antioxidant activity, only α-, and γ-tocopherol, and Trolox had antioxidant properties. However, only α-tocopherol, γ-tocopherol and OA were able to impair 7KC-induced loss of mitochondrial transmembrane potential, which is associated with increased permeability to propidium iodide, an indicator of cell death. In addition, α-and γ-tocopherol, and OA were able to prevent the decrease in Abcd3 protein levels, which allows the measurement of peroxisomal mass, and in mRNA levels of Abcd1 and Abcd2, which encode for two transporters involved in peroxisomal β-oxidation. Thus, 7KC-induced side effects are associated with mitochondrial and peroxisomal dysfunction which can be inversed by natural compounds, thus supporting the hypothesis that the composition of the diet can act on the function of organelles involved in neurodegenerative diseases. PMID:27897980

A light-regulated type I pilus contributes to Acinetobacter baumannii biofilm, motility and virulence functions.

PubMed

Wood, Cecily R; Ohneck, Emily J; Edelmann, Richard E; Actis, Luis A

2018-06-11

Transcriptional analyses of A. baumannii ATCC 17978 showed that the expression of A1S_2091 was enhanced in cells cultured in darkness at 24°C through a process that depended on the BlsA photoreceptor. Disruption of A1S_2091, a component of the A1S_2088-A1S_2091 polycistronic operon predicted to code for a type I chaperone/usher pilus assembly system, abolished surface motility and pellicle formation but significantly enhanced biofilm formation on plastic by bacteria cultured under darkness. Based on these observations, the A1S_2088-A1S_2091 operon was named the p hoto- r egulated p ilus ABCD ( prpABCD ) operon, with A1S_2091 coding for the PrpA pilin subunit. Unexpectedly, the comparative analyses of ATCC 17978 and prpA isogenic mutant cells cultured at 37°C showed the expression of light-regulated biofilm biogenesis and motility functions under a temperature condition that drastically affects BlsA production and its light sensing activity. These assays also suggest that 17978 cells produce alternative light-regulated adhesins and/or pili systems that enhance bacterial adhesion and biofilm formation both at 24°C and 37°C on plastic as well as on the surface of polarized A549 alveolar epithelial cells, where formation of bacterial filaments and cell chains was significantly enhanced. The inactivation of prpA also resulted in a significant reduction in virulence when tested using the Galleria mellonella virulence model. All these observations provide strong evidence showing the capacity of A. baumannii to sense light and interact with biotic and abiotic surfaces using undetermined alternative sensing and regulatory systems as well as alternative adherence and motility cellular functions that allow this pathogen to persist in different ecological niches. Copyright © 2018 American Society for Microbiology.

Synthesis and biological evaluation of manzamine analogues.

PubMed

Winkler, Jeffrey D; Londregan, Allyn T; Ragains, Justin R; Hamann, Mark T

2006-07-20

[Structure: see text] The synthesis and biological evaluation of a series of analogues of manzamine A, representing partial structures of the pentacyclic ABCDE diamine core, is described. All new compounds were screened against Plasmodium falciparum and demonstrated attenuated antimalarial activity relative to that of manzamine A.

Analog detection for cavity lifetime spectroscopy

DOEpatents

Zare, Richard N.; Harb, Charles C.; Paldus, Barbara A.; Spence, Thomas G.

2001-05-15

An analog detection system for determining a ring-down rate or decay rate 1/.tau. of an exponentially decaying ring-down beam issuing from a lifetime or ring-down cavity during a ring-down phase. Alternatively, the analog detection system determines a build-up rate of an exponentially growing beam issuing from the cavity during a ring-up phase. The analog system can be employed in continuous wave cavity ring-down spectroscopy (CW CRDS) and pulsed CRDS (P CRDS) arrangements utilizing any type of ring-down cavity including ring-cavities and linear cavities.

Analog detection for cavity lifetime spectroscopy

DOEpatents

Zare, Richard N.; Harb, Charles C.; Paldus, Barbara A.; Spence, Thomas G.

2003-01-01

An analog detection system for determining a ring-down rate or decay rate 1/.tau. of an exponentially decaying ring-down beam issuing from a lifetime or ring-down cavity during a ring-down phase. Alternatively, the analog detection system determines a build-up rate of an exponentially growing beam issuing from the cavity during a ring-up phase. The analog system can be employed in continuous wave cavity ring-down spectroscopy (CW CRDS) and pulsed CRDS (P CRDS) arrangements utilizing any type of ring-down cavity including ring-cavities and linear cavities.

A Pauson-Khand and ring-expansion approach to the aquariane ring system.

PubMed

Thornton, Paul D; Burnell, D Jean

2006-07-20

[Structure: see text] The carbocyclic ring system of the aquariolide diterpenes has been synthesized by two routes involving a diastereoselective Pauson-Khand reaction and subsequent ring expansion. In one route, a tetracyclic enone was elaborated to generate the nine-membered ring by Grob fragmentation. In the second approach, a spirocyclic tricycle underwent a facile anionic oxy-Cope rearrangement to complete the synthesis of the desired ring system.

Planetary Rings

NASA Astrophysics Data System (ADS)

Tiscareno, Matthew S.

Planetary rings are the only nearby astrophysical disks and the only disks that have been investigated by spacecraft (especially the Cassini spacecraft orbiting Saturn). Although there are significant differences between rings and other disks, chiefly the large planet/ring mass ratio that greatly enhances the flatness of rings (aspect ratios as small as 10- 7), understanding of disks in general can be enhanced by understanding the dynamical processes observed at close range and in real time in planetary rings.We review the known ring systems of the four giant planets, as well as the prospects for ring systems yet to be discovered. We then review planetary rings by type. The A, B, and C rings of Saturn, plus the Cassini Division, comprise our solar system's only dense broad disk and host many phenomena of general application to disks including spiral waves, gap formation, self-gravity wakes, viscous overstability and normal modes, impact clouds, and orbital evolution of embedded moons. Dense narrow rings are found both at Uranus (where they comprise the main rings entirely) and at Saturn (where they are embedded in the broad disk) and are the primary natural laboratory for understanding shepherding and self-stability. Narrow dusty rings, likely generated by embedded source bodies, are surprisingly found to sport azimuthally confined arcs at Neptune, Saturn, and Jupiter. Finally, every known ring system includes a substantial component of diffuse dusty rings.Planetary rings have shown themselves to be useful as detectors of planetary processes around them, including the planetary magnetic field and interplanetary impactors as well as the gravity of nearby perturbing moons. Experimental rings science has made great progress in recent decades, especially numerical simulations of self-gravity wakes and other processes but also laboratory investigations of coefficient of restitution and spectroscopic ground truth. The age of self-sustained ring systems is a matter of debate; formation scenarios are most plausible in the context of the early solar system, while signs of youthfulness indicate at least that rings have never been static phenomena.

Community Asset Mapping. Trends and Issues Alert.

ERIC Educational Resources Information Center

Kerka, Sandra

Asset mapping involves documenting tangible and intangible resources of a community viewed as a place with assets to be preserved and enhanced, not deficits to be remedied. Kretzmann and McKnight (1993) are credited with developing the concept of asset-based community development (ABCD) that draws on appreciative inquiry; recognition of social…

On-scene treatment of spinal injuries in motor sports.

PubMed

Kreinest, M; Scholz, M; Trafford, P

2017-04-01

Because spinal cord injuries can have fatal consequences for injured race car drivers, prehospital treatment of spinal injuries is a major concern in motor sports. A structured procedure for assessing trauma patients and their treatment should follow established ABCDE principles. Only then, a stable patient could be further examined and appropriate measures can be undertaken. For patients in an acute life-threatening condition, rapid transport must be initiated and should not be delayed by measures that are not indicated. If a competitor must first be extricated from the racing vehicle, the correct method of extrication must be chosen. To avoid secondary injury to the spine after a racing accident, in-line extrication from the vehicle and immobilization of the patient are standard procedures in motor sports and have been used for decades. Since immobilization can be associated with disadvantages and complications, the need for immobilization of trauma patients outside of motor sports medicine has become the subject of an increasing number of reports in the scientific literature. Even in motor sports, where specific safety systems that offer spinal protection are present, the indications for spinal immobilization need to be carefully considered rather than being blindly adopted as a matter of course. The aim of this article is to use recent literature to present an overview about the treatment of spinal injuries in motor sports. Further, we present a new protocol for indications for immobilizing the spine in motor sports that is based on the ABCDE principles and takes into account the condition of the patient.

Cloning and characterization of a Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.

PubMed Central

Yen, K M; Karl, M R; Blatt, L M; Simon, M J; Winter, R B; Fausset, P R; Lu, H S; Harcourt, A A; Chen, K K

1991-01-01

Pseudomonas mendocina KR1 metabolizes toluene as a carbon source by a previously unknown pathway. The initial step of the pathway is hydroxylation of toluene to form p-cresol by a multicomponent toluene-4-monooxygenase (T4MO) system. The T4MO enzyme system has broad substrate specificity and provides a new opportunity for biodegradation of toxic compounds and bioconversions. Its known activities include conversion of a variety of phenyl compounds into the phenolic derivatives and the complete degradation of trichloroethylene. We have cloned and characterized a gene cluster from KR1 that determines the offO activity. To clone the T4MO genes, KR1 DNA libraries were constructed in Escherichia coli HB101 by using a broad-host-range vector and transferred to a KR1 mutant able to grow on p-cresol but not on toluene. An insert consisting of two SacI fragments of identical size (10.2 kb) was shown to complement the mutant for growth on toluene. One of the SacI fragments, when cloned into the E. coli vector pUC19, was found to direct the synthesis of indigo dye. The indigo-forming property was correlated with the presence of T4MO activity. The T4MO genes were mapped to a 3.6-kb region, and the direction of transcription was determined. DNA sequencing and N-terminal amino acid determination identified a five-gene cluster, tmoABCDE, within this region. Expression of this cluster carrying a single mutation in each gene demonstrated that each of the five genes is essential for T4MO activity. Other evidence presented indicated that none of the tmo genes was involved in the regulation of the tmo gene cluster, in the control of substrate transport for the T4MO system, or in major processing of the products of the tmo genes. It was tentatively concluded that the tmoABCDE genes encode structural polypeptides of the T4MO enzyme system. One of the tmo genes was tentatively identified as a ferredoxin gene. Images PMID:1885512

Beam propagation factor based on the Rényi entropy.

PubMed

Vaveliuk, Pablo; da Silva, Marcone Lopes

2008-09-15

A beam width measure based on Rényi entropy was introduced by Luis [Opt. Lett 31, 3644 (2006)]. That one-dimensional analysis was limited to beam profiles with rectangular symmetry. In this Letter, we derive a general Rényi beam width measure that accounts for the diffraction properties of beams with profiles of arbitrary symmetry. We also show that the square of this measure has a quadratic dependence as a function of the propagation coordinate, so that it can be applied to propagation through arbitrary ABCD paraxial systems. The Rényi beam propagation factor, here introduced, is discussed in examples where the M(2) factor seems to have a limited effectiveness in describing the beam spreading.

An optical system with aberrations on diffraction integrals written in terms of a generalized ABCD matrix

NASA Astrophysics Data System (ADS)

Zhao, Chaoying; Tan, Weihan

2008-12-01

: In this paper, we consider the transformation of a ray beam as it passes through an optical system containing a glass plate with parallel surfaces inclined to the optical axis at the Brewster’s angle, by investigating the effects of the optical system on amplitude and phase distributions. By applying generalized matrix optics and diffraction integrals and considering the influence of a quarter of a wavelength of aberration on the transmitted amplitude and phase distributions at the focus of a de-collimating lens, we find that the central peak amplitude descends from 1.0 to 0.8 and the phase distortion is less than π/2. The general feature of the amplitude distribution shows an elongation along the y-axis perpendicular to the optical axis in the direction of tilt of the inclined plate, and conforms to the inclination direction of the glass plate.

A survey of candidate missions to explore Saturn's rings

NASA Technical Reports Server (NTRS)

Wells, W. C.; Price, M. J.

1972-01-01

The ring system around Saturn is discussed. Exploration of the rings is required for an understanding of their origin and the hazard they represent to spacecraft near Saturn. In addition the rings may provide useful clues to the origin of the solar system. This study examines the problem of ring system exploration and recommends a sequence of missions which will collect the data required.

Optical heterodyne detection for cavity ring-down spectroscopy

DOEpatents

Levenson, Marc D.; Paldus, Barbara A.; Zare, Richard N.

2000-07-25

A cavity ring-down system for performing cavity ring-down spectroscopy (CRDS) using optical heterodyne detection of a ring-down wave E.sub.RD during a ring-down phase or a ring-up wave E.sub.RU during a ring up phase. The system sends a local oscillator wave E.sub.LO and a signal wave E.sub.SIGNAL to the cavity, preferably a ring resonator, and derives an interference signal from the combined local oscillator wave E.sub.LO and the ring-down wave E.sub.RD (or ring-up wave E.sub.RU). The local oscillator wave E.sub.LO has a first polarization and the ring-down wave E.sub.RD has a second polarization different from the first polarization. The system has a combining arrangement for combining or overlapping local oscillator wave E.sub.LO and the ring-down wave E.sub.RD at a photodetector, which receives the interference signal and generates a heterodyne current I.sub.H therefrom. Frequency and phase differences between the waves are adjustable.

Dual annular rotating "windowed" nuclear reflector reactor control system

DOEpatents

Jacox, Michael G.; Drexler, Robert L.; Hunt, Robert N. M.; Lake, James A.

1994-01-01

A nuclear reactor control system is provided in a nuclear reactor having a core operating in the fast neutron energy spectrum where criticality control is achieved by neutron leakage. The control system includes dual annular, rotatable reflector rings. There are two reflector rings: an inner reflector ring and an outer reflector ring. The reflectors are concentrically assembled, surround the reactor core, and each reflector ring includes a plurality of openings. The openings in each ring are capable of being aligned or non-aligned with each other. Independent driving means for each of the annular reflector rings is provided so that reactor criticality can be initiated and controlled by rotation of either reflector ring such that the extent of alignment of the openings in each ring controls the reflection of neutrons from the core.

The ABCDs of Service-Learning: Who Is Serving Whom?

ERIC Educational Resources Information Center

Lieberman, Devorah

2014-01-01

The concept of and approach to service-learning across higher education has changed dramatically over the last two and a half decades. Historically, one of the primary goals of service-learning was to prepare undergraduate students to become engaged citizens and to introduce them to the challenges experienced by individuals from marginalized or…

Physical Education Resource Guide: Kindergarten to Grade 12. ABCD's of Physical Education.

ERIC Educational Resources Information Center

Glassford, Jeanine; Jordan, Dave

This guide identifies resources that can support program planning for implementation of the Physical Education Program of Studies, Kindergarten to Grade 12, Alberta, Canada. The program is indented to enable individuals to develop the knowledge, skills, and attitudes necessary to lead an active, healthy lifestyle. The program emphasizes active…

Multiple forms of Spire-actin complexes and their functional consequences.

PubMed

Chen, Christine K; Sawaya, Michael R; Phillips, Martin L; Reisler, Emil; Quinlan, Margot E

2012-03-23

Spire is a WH2 domain-containing actin nucleator essential for establishing an actin mesh during oogenesis. In vitro, in addition to nucleating filaments, Spire can sever them and sequester actin monomers. Understanding how Spire is capable of these disparate functions and which are physiologically relevant is an important goal. To study severing, we examined the effect of Drosophila Spire on preformed filaments in bulk and single filament assays. We observed rapid depolymerization of actin filaments by Spire, which we conclude is largely due to its sequestration activity and enhanced by its weak severing activity. We also studied the solution and crystal structures of Spire-actin complexes. We find structural and functional differences between constructs containing four WH2 domains (Spir-ABCD) and two WH2 domains (Spir-CD) that may provide insight into the mechanisms of nucleation and sequestration. Intriguingly, we observed lateral interactions between actin monomers associated with Spir-ABCD, suggesting that the structures built by these four tandem WH2 domains are more complex than originally imagined. Finally, we propose that Spire-actin mixtures contain both nuclei and sequestration structures.

Development of an Acoustic Levitation Linear Transportation System Based on a Ring-Type Structure.

PubMed

Thomas, Gilles P L; Andrade, Marco A B; Adamowski, Julio Cezar; Silva, Emilio Carlos Nelli

2017-05-01

A linear acoustic levitation transportation system based on a ring-type vibrator is presented. The system is composed by two 21-kHz Langevin transducers connected to a ring-shaped structure formed by two semicircular sections and two flat plates. In this system, a flexural standing wave is generated along the ring structure, producing an acoustic standing wave between the vibrating ring and a plane reflector located at a distance of approximately a half wavelength from the ring. The acoustic standing wave in air has a series of pressure nodes, where small particles can be levitated and transported. The ring-type transportation system was designed and analyzed by using the finite element method. Additionally, a prototype was built and the acoustic levitation and transport of a small polystyrene particle was demonstrated.

The composition and structure of planetary rings

NASA Technical Reports Server (NTRS)

Burns, J. A.

1985-01-01

The properties of planetary ring systems are summarized herein; emphasis is given to the available evidence on their compositions and to their dynamical attributes. Somewhat contaminated water ice makes up the vast expanse of Saturn's rings. Modified methane ice may comprise Uranus' rings while silicates are the likely material of the Jovian ring. Saturn's rings form an elaborate system whose characteristics are still being documented and whose nature is being unravelled following the Voyager flybys. Uranus' nine narrow bands display an intriguing dynamical structure thought to be caused by unseen shephard satellites. Jupiter's ring system is a mere wisp, probably derived as ejecta off hidden parent bodies.

Androgynous, Reconfigurable Closed Loop Feedback Controlled Low Impact Docking System With Load Sensing Electromagnetic Capture Ring

NASA Technical Reports Server (NTRS)

Lewis, James L. (Inventor); Carroll, Monty B. (Inventor); Morales, Ray H. (Inventor); Le, Thang D. (Inventor)

2002-01-01

The present invention relates to a fully androgynous, reconfigurable closed loop feedback controlled low impact docking system with load sensing electromagnetic capture ring. The docking system of the present invention preferably comprises two Docking- assemblies, each docking assembly comprising a load sensing ring having an outer face, one of more electromagnets, one or more load cells coupled to said load sensing ring. The docking assembly further comprises a plurality of actuator arms coupled to said load sensing ring and capable of dynamically adjusting the orientation of said load sensing ring and a reconfigurable closed loop control system capable of analyzing signals originating from said plurality of load cells and of outputting real time control for each of the actuators. The docking assembly of the present invention incorporates an active load sensing system to automatically dynamically adjust the load sensing ring during capture instead of requiring significant force to push and realign the ring.

Virtual Exploration of the Ring Systems Chemical Universe.

PubMed

Visini, Ricardo; Arús-Pous, Josep; Awale, Mahendra; Reymond, Jean-Louis

2017-11-27

Here, we explore the chemical space of all virtually possible organic molecules focusing on ring systems, which represent the cyclic cores of organic molecules obtained by removing all acyclic bonds and converting all remaining atoms to carbon. This approach circumvents the combinatorial explosion encountered when enumerating the molecules themselves. We report the chemical universe database GDB4c containing 916 130 ring systems up to four saturated or aromatic rings and maximum ring size of 14 atoms and GDB4c3D containing the corresponding 6 555 929 stereoisomers. Almost all (98.6%) of these ring systems are unknown and represent chiral 3D-shaped macrocycles containing small rings and quaternary centers reminiscent of polycyclic natural products. We envision that GDB4c can serve to select new ring systems from which to design analogs of such natural products. The database is available for download at www.gdb.unibe.ch together with interactive visualization and search tools as a resource for molecular design.

Boomerang Satellites

NASA Astrophysics Data System (ADS)

Hesselbrock, Andrew; Minton, David A.

2017-10-01

We recently reported that the orbital architecture of the Martian environment allows for material in orbit around the planet to ``cycle'' between orbiting the planet as a ring, or as coherent satellites. Here we generalize our previous analysis to examine several factors that determine whether satellites accreting at the edge of planetary rings will cycle. In order for the orbiting material to cycle, tidal evolution must decrease the semi-major axis of any accreting satellites. In some systems, the density of the ring/satellite material, the surface mass density of the ring, the tidal parameters of the system, and the rotation rate of the primary body contribute to a competition between resonant ring torques and tidal dissipation that prevent this from occurring, either permanently or temporarily. Analyzing these criteria, we examine various bodies in our solar system (such as Saturn, Uranus, and Eris) to identify systems where cycling may occur. We find that a ring-satellite cycle may give rise to the current Uranian ring-satellite system, and suggest that Miranda may have formed from an early, more massive Uranian ring.

Dual annular rotating [open quotes]windowed[close quotes] nuclear reflector reactor control system

DOEpatents

Jacox, M.G.; Drexler, R.L.; Hunt, R.N.M.; Lake, J.A.

1994-03-29

A nuclear reactor control system is provided in a nuclear reactor having a core operating in the fast neutron energy spectrum where criticality control is achieved by neutron leakage. The control system includes dual annular, rotatable reflector rings. There are two reflector rings: an inner reflector ring and an outer reflector ring. The reflectors are concentrically assembled, surround the reactor core, and each reflector ring includes a plurality of openings. The openings in each ring are capable of being aligned or non-aligned with each other. Independent driving means for each of the annular reflector rings is provided so that reactor criticality can be initiated and controlled by rotation of either reflector ring such that the extent of alignment of the openings in each ring controls the reflection of neutrons from the core. 4 figures.

Flower development and sex specification in wild grapevine.

PubMed

Ramos, Miguel Jesus Nunes; Coito, João Lucas; Silva, Helena Gomes; Cunha, Jorge; Costa, Maria Manuela Ribeiro; Rocheta, Margarida

2014-12-12

Wild plants of Vitis closely related to the cultivated grapevine (V. v. vinifera) are believed to have been first domesticated 10,000 years BC around the Caspian Sea. V. v. vinifera is hermaphrodite whereas V. v. sylvestris is a dioecious species. Male flowers show a reduced pistil without style or stigma and female flowers present reflexed stamens with infertile pollen. V. vinifera produce perfect flowers with all functional structures. The mechanism for flower sex determination and specification in grapevine is still unknown. To understand which genes are involved during the establishment of male, female and complete flowers, we analysed and compared the transcription profiles of four developmental stages of the three genders. We showed that sex determination is a late event during flower development and that the expression of genes from the ABCDE model is not directly correlated with the establishment of sexual dimorphism. We propose a temporal comprehensive model in which two mutations in two linked genes could be players in sex determination and indirectly establish the Vitis domestication process. Additionally, we also found clusters of genes differentially expressed between genders and between developmental stages that suggest a role involved in sex differentiation. Also, the detection of differentially transcribed regions that extended existing gene models (intergenic regions) between sexes suggests that they may account for some of the variation between the subspecies. There is no evidence of differences of expression levels in genes from the ABCDE model that could explain the shift from hermaphroditism to dioecy. We propose that sex specification occurs after floral organ identity has been established and therefore, sex determination genes might be having an effect downstream of the ABCDE model genes.For the first time a full transcriptomic analysis was performed in different flower developmental stages in the same individual. Our experimental approach enabled us to create a comprehensive catalogue of transcribed genes across developmental stages and genders that will contribute for future work in sex determination in seed plants.

Diagnosing malignant melanoma in ambulatory care: a systematic review of clinical prediction rules.

PubMed

Harrington, Emma; Clyne, Barbara; Wesseling, Nieneke; Sandhu, Harkiran; Armstrong, Laura; Bennett, Holly; Fahey, Tom

2017-03-06

Malignant melanoma has high morbidity and mortality rates. Early diagnosis improves prognosis. Clinical prediction rules (CPRs) can be used to stratify patients with symptoms of suspected malignant melanoma to improve early diagnosis. We conducted a systematic review of CPRs for melanoma diagnosis in ambulatory care. Systematic review. A comprehensive search of PubMed, EMBASE, PROSPERO, CINAHL, the Cochrane Library and SCOPUS was conducted in May 2015, using combinations of keywords and medical subject headings (MeSH) terms. Studies deriving and validating, validating or assessing the impact of a CPR for predicting melanoma diagnosis in ambulatory care were included. Data extraction and methodological quality assessment were guided by the CHARMS checklist. From 16 334 studies reviewed, 51 were included, validating the performance of 24 unique CPRs. Three impact analysis studies were identified. Five studies were set in primary care. The most commonly evaluated CPRs were the ABCD, more than one or uneven distribution of Colour, or a large (greater than 6 mm) Diameter (ABCD) dermoscopy rule (at a cut-point of >4.75; 8 studies; pooled sensitivity 0.85, 95% CI 0.73 to 0.93, specificity 0.72, 95% CI 0.65 to 0.78) and the 7-point dermoscopy checklist (at a cut-point of ≥1 recommending ruling in melanoma; 11 studies; pooled sensitivity 0.77, 95% CI 0.61 to 0.88, specificity 0.80, 95% CI 0.59 to 0.92). The methodological quality of studies varied. At their recommended cut-points, the ABCD dermoscopy rule is more useful for ruling out melanoma than the 7-point dermoscopy checklist. A focus on impact analysis will help translate melanoma risk prediction rules into useful tools for clinical practice. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Reducing hydrologic model uncertainty in monthly streamflow predictions using multimodel combination

NASA Astrophysics Data System (ADS)

Li, Weihua; Sankarasubramanian, A.

2012-12-01

Model errors are inevitable in any prediction exercise. One approach that is currently gaining attention in reducing model errors is by combining multiple models to develop improved predictions. The rationale behind this approach primarily lies on the premise that optimal weights could be derived for each model so that the developed multimodel predictions will result in improved predictions. A new dynamic approach (MM-1) to combine multiple hydrological models by evaluating their performance/skill contingent on the predictor state is proposed. We combine two hydrological models, "abcd" model and variable infiltration capacity (VIC) model, to develop multimodel streamflow predictions. To quantify precisely under what conditions the multimodel combination results in improved predictions, we compare multimodel scheme MM-1 with optimal model combination scheme (MM-O) by employing them in predicting the streamflow generated from a known hydrologic model (abcd model orVICmodel) with heteroscedastic error variance as well as from a hydrologic model that exhibits different structure than that of the candidate models (i.e., "abcd" model or VIC model). Results from the study show that streamflow estimated from single models performed better than multimodels under almost no measurement error. However, under increased measurement errors and model structural misspecification, both multimodel schemes (MM-1 and MM-O) consistently performed better than the single model prediction. Overall, MM-1 performs better than MM-O in predicting the monthly flow values as well as in predicting extreme monthly flows. Comparison of the weights obtained from each candidate model reveals that as measurement errors increase, MM-1 assigns weights equally for all the models, whereas MM-O assigns higher weights for always the best-performing candidate model under the calibration period. Applying the multimodel algorithms for predicting streamflows over four different sites revealed that MM-1 performs better than all single models and optimal model combination scheme, MM-O, in predicting the monthly flows as well as the flows during wetter months.

Genes of the N-Methylglutamate Pathway Are Essential for Growth of Methylobacterium extorquens DM4 with Monomethylamine

PubMed Central

Gruffaz, Christelle; Muller, Emilie E. L.; Louhichi-Jelail, Yousra; Nelli, Yella R.; Guichard, Gilles

2014-01-01

Monomethylamine (MMA, CH3NH2) can be used as a carbon and nitrogen source by many methylotrophic bacteria. Methylobacterium extorquens DM4 lacks the MMA dehydrogenase encoded by mau genes, which in M. extorquens AM1 is essential for growth on MMA. Identification and characterization of minitransposon mutants with an MMA-dependent phenotype showed that strain DM4 grows with MMA as the sole source of carbon, energy, and nitrogen by the N-methylglutamate (NMG) pathway. Independent mutations were found in a chromosomal region containing the genes gmaS, mgsABC, and mgdABCD for the three enzymes of the pathway, γ-glutamylmethylamide (GMA) synthetase, NMG synthase, and NMG dehydrogenase, respectively. Reverse transcription-PCR confirmed the operonic structure of the two divergent gene clusters mgsABC-gmaS and mgdABCD and their induction during growth with MMA. The genes mgdABCD and mgsABC were found to be essential for utilization of MMA as a carbon and nitrogen source. The gene gmaS was essential for MMA utilization as a carbon source, but residual growth of mutant DM4gmaS growing with succinate and MMA as a nitrogen source was observed. Plasmid copies of gmaS and the gmaS homolog METDI4690, which encodes a protein 39% identical to GMA synthetase, fully restored the ability of mutants DM4gmaS and DM4gmaSΔmetdi4690 to use MMA as a carbon and nitrogen source. Similarly, chemically synthesized GMA, the product of GMA synthetase, could be used as a nitrogen source for growth in the wild-type strain, as well as in DM4gmaS and DM4gmaSΔmetdi4690 mutants. The NADH:ubiquinone oxidoreductase respiratory complex component NuoG was also found to be essential for growth with MMA as a carbon source. PMID:24682302

Improvement of FK506 Production in the High-Yielding Strain Streptomyces sp. RM7011 by Engineering the Supply of Allylmalonyl-CoA Through a Combination of Genetic and Chemical Approach.

PubMed

Mo, SangJoon; Lee, Sung-Kwon; Jin, Ying-Yu; Suh, Joo-Won

2016-02-01

FK506, a widely used immunosuppressant, is a 23-membered polyketide macrolide that is produced by several Streptomyces species. FK506 high-yielding strain Streptomyces sp. RM7011 was developed from the discovered Streptomyces sp. KCCM 11116P by random mutagenesis in our previous study. The results of transcript expression analysis showed that the transcription levels of tcsA, B, C, and D were increased in Streptomyces sp. RM7011 by 2.1-, 3.1-, 3.3-, and 4.1- fold, respectively, compared with Streptomyces sp. KCCM 11116P. The overexpression of tcsABCD genes in Streptomyces sp. RM7011 gave rise to approximately 2.5-fold (238.1 μg/ml) increase in the level of FK506 production compared with that of Streptomyces sp. RM7011. When vinyl pentanoate was added into the culture broth of Streptomyces sp. RM7011, the level of FK506 production was approximately 2.2-fold (207.7 μg/ml) higher than that of the unsupplemented fermentation. Furthermore, supplementing the culture broth of Streptomyces sp. RM7011 expressing tcsABCD genes with vinyl pentanoate resulted in an additional 1.7-fold improvement in the FK506 titer (498.1 μg/ml) compared with that observed under nonsupplemented condition. Overall, the level of FK506 production was increased approximately 5.2-fold by engineering the supply of allylmalonyl-CoA in the high-yielding strain Streptomyces sp. RM7011, using a combination of overexpressing tcsABCD genes and adding vinyl pentanoate, as compared with Streptomyces sp. RM7011 (95.3 μg/ml). Moreover, among the three precursors analyzed, pentanoate was the most effective precursor, supporting the highest titer of FK506 in the FK506 high-yielding strain Streptomyces sp. RM7011.

Role of keto acids and reduced-oxygen-scavenging enzymes in the growth of Legionella species.

PubMed Central

Pine, L; Hoffman, P S; Malcolm, G B; Benson, R F; Franzus, M J

1986-01-01

Keto acids and reduced-oxygen-scavenging enzymes were examined for their roles in supporting the growth of Legionella species and for their potential reactions between the chemical components of the media. When grown in an experimental ACES (2-[(2-amino-2-oxoethyl)-amino] ethanesulfonic acid)-buffered chemically defined (ABCD) broth, the presence of keto acids shortened the lag periods, increased the rates of growth, and gave maximum cell yields. In addition, keto acids affected the specific activities of reduced-oxygen-scavenging enzymes determined during growth. The specific activities of superoxide dismutase of Legionella pneumophila (Knoxville) and L. dumoffii (TEX-KL) were increased three- to eightfold, while that of L. bozemanii (WIGA) was not affected. All strains appeared to be equally sensitive to the effects of superoxide anion (O2-) generated by light-activated riboflavin, and all were equally protected by the presence of keto acids in the ABCD broth. Production of trace amounts of acetate and succinate in pyruvate- and alpha-ketoglutarate-containing media exposed to light suggested that hydrogen peroxide was formed. Pyruvate and alpha-ketoglutarate were products of growth on amino acids, and there was no quantitative evidence that these keto acids were metabolized when they were added to the medium. The rate of cysteine oxidation in ABCD broth was increased by the presence of ferric ion or by exposure to light or by both, and keto acids reduced the rate of this oxidation. ACES buffer was a substrate for the production of O2- in the presence of light, and the combined addition of Fe2+ ions, cysteine, and either keto acid to the medium strongly inhibited the production of O2-. Thus, keto acids inhibited the rate of cysteine oxidation, they stimulated rapid growth by an unknown process, and, in combination with added Fe2+ ions and cysteine, they reversed the toxic effects of light by inhibiting O2- production. PMID:3009529

Lectures on algebraic system theory: Linear systems over rings

NASA Technical Reports Server (NTRS)

Kamen, E. W.

1978-01-01

The presentation centers on four classes of systems that can be treated as linear systems over a ring. These are: (1) discrete-time systems over a ring of scalars such as the integers; (2) continuous-time systems containing time delays; (3) large-scale discrete-time systems; and (4) time-varying discrete-time systems.

System for RFID-Enabled Information Collection

NASA Technical Reports Server (NTRS)

Kennedy, Timothy F. (Inventor); Fink, Patrick W. (Inventor); Lin, Gregory Y. (Inventor); Ngo, Phong H. (Inventor)

2017-01-01

A sensor and system provide for radio frequency identification (RFID)-enabled information collection. The sensor includes a ring-shaped element and an antenna. The ring-shaped element includes a conductive ring and an RFID integrated circuit. The antenna is spaced apart from the ring-shaped element and defines an electrically-conductive path commensurate in size and shape to at least a portion of the conductive ring. The system may include an interrogator for energizing the ring-shaped element and receiving a data transmission from the RFID integrated circuit that has been energized for further processing by a processor.

Saturn's Ring: Pre-Cassini Status and Mission Goals

NASA Astrophysics Data System (ADS)

Cuzzi, Jeff N.

1999-01-01

In November 1980, and again in August 1981, identical Voyager spacecraft flew through the Saturn system, changing forever the way we think about planetary rings. Although Saturn's rings had been the only known ring system for three centuries, a ring system around Uranus had been discovered by stellar occultations from Earth in 1977, and the nearly transparent ring of Jupiter was imaged by Voyager in 1979 (the presence of material there had been inferred from charged particle experiments on Pioneer 10 and 11 several years earlier). While Saturn had thus temporarily lost its uniqueness as having the only ring system, with Voyager it handily recaptured the role of having the most fascinating one. The Voyager breakthroughs included spiral density and bending waves such as cause galactic structure; ubiquitous fine-scale radial 'irregular' structure, with the appearance of record-grooves; regional and local variations in particle color; complex, azimuthally variable ring structure; empty gaps in the rings, some containing very regular, sharp-edged, elliptical rings and one containing both a small moonlet and incomplete arcs of dusty material; and shadowy 'spokes' that flicker across the main rings. One of the paradigm shifts of this period was the realization that many aspects of planetary rings, and even the ring systems themselves, could be 'recent' on geological timescales. These early results are reviewed and summarized in the Arizona Space Science series volumes 'Saturn'. (An excellent review of ring dynamics at a formative stage is by Goldreich and Tremaine.) From the mid 1980's to the time of this writing, progress has been steady, while at a less heady pace, and some of the novel ring properties revealed by Voyager 1 and 2 are beginning to be better understood. It is clearly impossible to cite, much less review, every advance over the last decade; however, below we summarize the main advances in understanding of Saturn's rings since the mid 1980's, in the context of the Cassini Science Objectives.

The narrow rings of Jupiter, Saturn and Uranus

NASA Technical Reports Server (NTRS)

Dermott, S. F.; Murray, C. D.; Sinclair, A. T.

1980-01-01

The origin of the newly discovered narrow ring systems around Jupiter, Saturn and Uranus is considered. It is pointed out that both the Uranian and Jovian ring systems have mean orbital radii of 1.8 planetary radii and lie within the Roche zones of their respective planets, and it is suggested that the Jovian ring is the product of the disintegration of a satellite that entered the Roche zone, and that large numbers of small particles are now in horseshoe orbits about the Lagrangian equilibrium points of the remnant chunks. Analysis of the path of a ring particle in a horseshoe orbit is shown to result in ring structures in agreement with those observed for the circular rings of Jupiter and the highly eccentric ring of Uranus. The stability of these ring systems is then considered, and it is suggested that the F ring of Saturn, which lies outside the Roche zone, represents primordial matter not yet accreted by small satellites just inside the Mimas first-order resonances.

Feline leukaemia. ABCD guidelines on prevention and management.

PubMed

Lutz, Hans; Addie, Diane; Belák, Sándor; Boucraut-Baralon, Corine; Egberink, Herman; Frymus, Tadeusz; Gruffydd-Jones, Tim; Hartmann, Katrin; Hosie, Margaret J; Lloret, Albert; Marsilio, Fulvio; Pennisi, Maria Grazia; Radford, Alan D; Thiry, Etienne; Truyen, Uwe; Horzinek, Marian C

2009-07-01

Feline leukaemia virus (FeLV) is a retrovirus that may induce depression of the immune system, anaemia and/or lymphoma. Over the past 25 years, the prevalence of FeLV infection has decreased considerably, thanks both to reliable tests for the identification of viraemic carriers and to effective vaccines. Transmission between cats occurs mainly through friendly contacts, but also through biting. In large groups of non-vaccinated cats, around 30-40% will develop persistent viraemia, 30-40% show transient viraemia and 20-30% seroconvert. Young kittens are especially susceptible to FeLV infection. The most common signs of persistent FeLV viraemia are immune suppression, anaemia and lymphoma. Less common signs are immune-mediated disease, chronic enteritis, reproductive disorders and peripheral neuropathies. Most persistently viraemic cats die within 2-3 years. In low-prevalence areas there may be a risk of false-positive results; a doubtful positive test result in a healthy cat should therefore be confirmed, preferably by PCR for provirus. Asymptomatic FeLV-positive cats should be retested. Supportive therapy and good nursing care are required. Secondary infections should be treated promptly. Cats infected with FeLV should remain indoors. Vaccination against common pathogens should be maintained. Inactivated vaccines are recommended. The virus does not survive for long outside the host. All cats with an uncertain FeLV status should be tested prior to vaccination. All healthy cats at potential risk of exposure should be vaccinated against FeLV. Kittens should be vaccinated at 8-9 weeks of age, with a second vaccination at 12 weeks, followed by a booster 1 year later. The ABCD suggests that, in cats older than 3-4 years of age, a booster every 2-3 years suffices, in view of the significantly lower susceptibility of older cats.

Genetic Variability of the Heme Uptake System among Different Strains of the Fish Pathogen Vibrio anguillarum: Identification of a New Heme Receptor

PubMed Central

Mouriño, Susana; Rodríguez-Ares, Isabel; Osorio, Carlos R.; Lemos, Manuel L.

2005-01-01

The ability to utilize heme compounds as iron sources was investigated in Vibrio anguillarum strains belonging to serotypes O1 to O10. All strains, regardless of their serotype or isolation origin could utilize hemin and hemoglobin as sole iron sources. Similarly, all of the isolates could bind hemin and Congo red, and this binding was mediated by cell envelope proteins. PCR and Southern hybridization were used to assay the occurrence of heme transport genes huvABCD, which have been previously described in serotype O1. Of 23 strains studied, two serotype O3 isolates proved negative for all huvABCD genes, whereas nine strains included in serotypes O2, O3, O4, O6, O7, and O10 tested negative for the outer membrane heme receptor gene huvA. A gene coding for a novel outer membrane heme receptor was cloned and characterized in a V. anguillarum serotype O3 strain lacking huvA. The new heme receptor, named HuvS, showed significant similarity to other outer membrane heme receptors described in Vibrionaceae, but little homology (39%) to HuvA. This heme receptor was present in 9 out of 11 of the V. anguillarum strains that tested negative for HuvA. Furthermore, complementation experiments demonstrated that HuvS could substitute for the HuvA function in Escherichia coli and V. anguillarum mutants. The huvS and huvA sequences alignment, as well as the analysis of their respective upstream and downstream DNA sequences, suggest that horizontal transfer and recombination might be responsible for generating this genetic diversity. PMID:16332832

Host Cell Contact-Induced Transcription of the Type IV Fimbria Gene Cluster of Actinobacillus pleuropneumoniae

PubMed Central

Boekema, Bouke K. H. L.; Van Putten, Jos P. M.; Stockhofe-Zurwieden, Norbert; Smith, Hilde E.

2004-01-01

Type IV pili (Tfp) of gram-negative species share many characteristics, including a common architecture and conserved biogenesis pathway. Much less is known about the regulation of Tfp expression in response to changing environmental conditions. We investigated the diversity of Tfp regulatory systems by searching for the molecular basis of the reported variable expression of the Tfp gene cluster of the pathogen Actinobacillus pleuropneumoniae. Despite the presence of an intact Tfp gene cluster consisting of four genes, apfABCD, no Tfp were formed under standard growth conditions. Sequence analysis of the predicted major subunit protein ApfA showed an atypical alanine residue at position −1 from the prepilin peptidase cleavage site in 42 strains. This alanine deviates from the consensus glycine at this position in Tfp from other species. Yet, cloning of the apfABCD genes under a constitutive promoter in A. pleuropneumoniae resulted in pilin and Tfp assembly. Tfp promoter-luxAB reporter gene fusions demonstrated that the Tfp promoter was intact but tightly regulated. Promoter activity varied with bacterial growth phase and was detected only when bacteria were grown in chemically defined medium. Infection experiments with cultured epithelial cells demonstrated that Tfp promoter activity was upregulated upon adherence of the pathogen to primary cultures of lung epithelial cells. Nonadherent bacteria in the culture supernatant exhibited virtually no promoter activity. A similar upregulation of Tfp promoter activity was observed in vivo during experimental infection of pigs. The host cell contact-induced and in vivo-upregulated Tfp promoter activity in A. pleuropneumoniae adds a new dimension to the diversity of Tfp regulation. PMID:14742510

The HD-GYP Domain Protein RpfG of Xanthomonas oryzae pv. oryzicola Regulates Synthesis of Extracellular Polysaccharides that Contribute to Biofilm Formation and Virulence on Rice

PubMed Central

Zhang, Yuanbao; Wei, Chao; Jiang, Wendi; Wang, Lei; Li, Churui; Wang, Yunyue; Dow, John Maxwell; Sun, Wenxian

2013-01-01

Bacterial leaf streak caused by Xanthomonas oryzae pv. oryzicola (Xoc) is one of the most important diseases in rice. However, little is known about the pathogenicity mechanisms of Xoc. Here we have investigated the function of three HD-GYP domain regulatory proteins in biofilm formation, the synthesis of virulence factors and virulence of Xoc. Deletion of rpfG resulted in altered production of extracellular polysaccharides (EPS), abolished virulence on rice and enhanced biofilm formation, but had little effect on the secretion of proteases and motility. In contrast, mutational analysis showed that the other two HD-GYP domain proteins had no effect on virulence factor synthesis and tested phenotypes. Mutation of rpfG led to up-regulation of the type III secretion system and altered expression of three putative glycosyltransferase genes gumD, pgaC and xagB, which are part of operons directing the synthesis of different extracellular polysaccharides. The pgaABCD and xagABCD operons were greatly up-regulated in the Xoc ΔrpfG mutant, whereas the expression of the gum genes was unaltered or slightly enhanced. The elevated biofilm formation of the Xoc ΔrpfG mutant was dramatically reduced upon deletion of gumD, xagA and xagB, but not when pgaA and pgaC were deleted. Interestingly, only the ΔgumD mutant, among these single gene mutants, exhibits multiple phenotype alterations including reduced biofilm and EPS production and attenuated virulence on rice. These data indicate that RpfG is a global regulator that controls biofilm formation, EPS production and bacterial virulence in Xoc and that both gumD- and xagB-dependent EPS contribute to biofilm formation under different conditions. PMID:23544067

[X-linked adrenoleukodystrophy: a report of three cases. The importance of early diagnosis].

PubMed

López Úbeda, Marta; de Arriba Muñoz, Antonio; Ferrer Lozano, Marta; Labarta Aizpún, José I; García Jiménez, María C

2017-10-01

X-linked adrenoleukodystrophy is the most common peroxisomal disorder. This disease is caused by a defect in the ABCD1 gen. Saturated very long chain fatty acids are accumulated in serum, adrenal cortex and central nervous system white matter. The clinical spectrum is characterized by progressive neurological dysfunction and adrenal insufficiency with a devastating prognosis. We report a first case of X-linked adrenoleukodystrophy with fatal evolution which identified two asymptomatic family members and established a preventive treatment. Although there is no definitive cure, we stress the importance of family study and evaluation of the individual in situation of risk to establish an early preventive treatment and to give in each particular situation suitable professional advice. Sociedad Argentina de Pediatría.

Shaping the beam profile of a partially coherent beam by a phase aperture

NASA Astrophysics Data System (ADS)

Wu, Gaofeng; Cai, Yangjian; Chen, Jun

2011-08-01

By use of a tensor method, an analytical formula for a partially coherent Gaussian Schell-model (GSM) beam truncated by a circular phase aperture propagating through a paraxial ABCD optical system is derived. The propagation properties of a GSM beam truncated by a circular phase aperture in free space are studied numerically. It is found that the circular phase aperture can be used to shape the beam profile of a GSM beam and generate partially coherent dark hollow or flat-topped beam, which is useful in many applications, e.g., optical trapping, free-space optical communication, and material thermal processing. The propagation factor of a GSM beam truncated by a circular phase aperture is also analyzed.

Image processing and analysis of Saturn's rings

NASA Technical Reports Server (NTRS)

Yagi, G. M.; Jepsen, P. L.; Garneau, G. W.; Mosher, J. A.; Doyle, L. R.; Lorre, J. J.; Avis, C. C.; Korsmo, E. P.

1981-01-01

Processing of Voyager image data of Saturn's rings at JPL's Image Processing Laboratory is described. A software system to navigate the flight images, facilitate feature tracking, and to project the rings has been developed. This system has been used to make measurements of ring radii and to measure the velocities of the spoke features in the B-Ring. A projected ring movie to study the development of these spoke features has been generated. Finally, processing to facilitate comparison of the photometric properties of Saturn's rings at various phase angles is described.

A Randomised Test of Printed Educational Materials about Melanoma Detection: Varying Skin Self-Examination Technique and Visual Image Dose

ERIC Educational Resources Information Center

King, Andy J.; Carcioppolo, Nick; Grossman, Douglas; John, Kevin K.; Jensen, Jakob D.

2015-01-01

Objective: Melanoma incidence and mortality rates continue to rise globally, making it essential for researchers to identify effective approaches to disseminating information to the public that improve key outcomes. This study compared two skin self-examination (SSE) educational strategies: the ABCDE (asymmetry, border irregularity, multiple…

Preparation of 3,3'-azobis(6-amino-1,2,4,5-tetrazine)

DOEpatents

Hiskey, Michael A.; Chavez, David E.; Naud, Darren

2002-01-01

The compound of the structure ##STR1## where a, b, c, d and e are 0 or 1 and a+b+c+d+e is from 0 to 5 is disclosed together with the species 3,3'-azobis(6-amino-1,2,4,5-tetrazine) and a process of preparing such compounds.

Central circuitry in the jellyfish Aglantha. II: The ring giant and carrier systems

PubMed

Mackie; Meech

1995-01-01

1. The ring giant axon in the outer nerve ring of the jellyfish Aglantha digitale is a multinucleate syncytium 85 % of which is occupied by an electron-dense fluid-filled vacuole apparently in a Gibbs­Donnan equilibrium with the surrounding band of cytoplasmic cortex. Micropipette recordings show small (-15 to -25 mV) and large (-62 to -66 mV) resting potentials. Low values, obtained with a high proportion of the micropipette penetrations, are assumed to be from the central vacuole; high values from the cytoplasmic cortex. Background electrical activity includes rhythmic oscillations and synaptic potentials representing hair cell input caused by vibration. 2. After the ring giant axon has been cut, propagating action potentials evoked by stimulation are conducted past the cut and re-enter the axon on the far side. The system responsible (the carrier system) through-conducts at a velocity approximately 25 % of that of the ring giant axon and is probably composed of small neurones running in parallel with it. Numerous small neurones are seen by electron microscopy, some making one-way and some two-way synapses with the ring giant. 3. Despite their different conduction velocities, the two systems normally appear to fire in synchrony and at the velocity of the ring giant axon. We suggest that, once initiated, ring giant spikes propagate rapidly around the margin, firing the carrier neurones through serial synapses and giving them, in effect, the same high conduction velocity. Initiation of ring giant spikes can, however, require input from the carrier system. The spikes are frequently seen to be mounted on slow positive potentials representing summed carrier postsynaptic potentials. 4. The carrier system fires one-for-one with the giant axons of the tentacles and may mediate impulse traffic between the latter and the ring giant axon. We suggest that the carrier system may also provide the pathways from the ring giant to the motor giant axons used in escape swimming. 5. The findings show that the ring giant axon functions in close collaboration with the carrier system, increasing the latter's effective conduction velocity, and that interactions with other neuronal sub-systems are probably mediated exclusively by the carrier system.

HST Observations of the Uranian Ring Plane Crossing: Early Results

NASA Astrophysics Data System (ADS)

Showalter, Mark R.; Lissauer, J. J.; French, R. G.; Hamilton, D. P.; Nicholson, P. D.; de Pater, I.

2007-10-01

Between early May and mid-August 2007, Earth was on the north side of the Uranian ring plane while the Sun was still shining on the rings’ southern face. This has provided an exceedingly rare opportunity to view the ring system via transmitted light. The ɛ ring, which typically out-shines every other component of the inner ring-moon system, has been rendered essentially invisible. We have been conducting regular imaging of the Uranian system throughout this period with the Wide Field/Planetary Camera on HST to address numerous scientific goals. (1) To search the inner Uranian system for the "shepherding” moons long believed to confine the narrow rings; (2) to study the packing density of the main rings via direct observations of their vertical thickness; (3) to search for the inner dust rings that appeared in a few Voyager images; (4) to determine the vertical thickness of the faint outer rings μ and ν (5) to obtain the most sensitive determinations of the outer rings’ colors and try to understand why ring ν is red but ring μ is blue; (6) to search for additional outer dust rings under optimal viewing geometry; and (7) to continue monitoring the seemingly chaotic orbital variations of the inner Uranian moons, particularly Mab. HST observations span mid-May to mid-September. We will present our initial results from this observing program.

Planetary Rings

NASA Astrophysics Data System (ADS)

Esposito, Larry W.

2011-07-01

Preface; 1. Introduction: the allure of ringed planets; 2. Studies of planetary rings 1610-2004; 3. Diversity of planetary rings; 4. Individual ring particles and their collisions; 5. Large-scale ring evolution; 6. Moons confine and sculpt rings; 7. Explaining ring phenomena; 8. N-Body simulations; 9. Stochastic models; 10. Age and evolution of rings; 11. Saturn's mysterious F ring; 12. Neptune's partial rings; 13. Jupiter's ring-moon system after Galileo; 14. Ring photometry; 15. Dusty rings; 16. Cassini observations; 17. Summary: the big questions; Glossary; References; Index.

Planetary Rings

NASA Astrophysics Data System (ADS)

Esposito, Larry

2014-03-01

Preface: a personal view of planetary rings; 1. Introduction: the allure of the ringed planets; 2. Studies of planetary rings 1610-2013; 3. Diversity of planetary rings; 4. Individual ring particles and their collisions; 5. Large-scale ring evolution; 6. Moons confine and sculpt rings; 7. Explaining ring phenomena; 8. N-body simulations; 9. Stochastic models; 10. Age and evolution of rings; 11. Saturn's mysterious F ring; 12. Uranus' rings and moons; 13. Neptune's partial rings; 14. Jupiter's ring-moon system after Galileo and New Horizons; 15. Ring photometry; 16. Dusty rings; 17. Concluding remarks; Afterword; Glossary; References; Index.

Expected first-order effects of a notional equatorial ring on Earth's night sky: a geometric consideration

NASA Astrophysics Data System (ADS)

Hancock, L. O.

2013-12-01

G. Jones (1856) was first to suggest that the Earth might have its own ring, noting that an Earth ring in the ecliptic plane would account for the latitude dependence of the zodiacal light. Jones's proposal was not accepted: it is difficult to see why the ecliptic would accumulate mass within the Earth-Moon system. Very recently, however, this objection has been mitigated by the discovery of Saturn's Phoebe ring: evidently, the plane of a planetary moon's orbit has now been observed as the site of mass accumulation. An adjustment of just a few degrees from ecliptic to the plane of the lunar orbit gives Jones's proposal the boost of an existing Solar System analogue, mysterious though the analogue is. J. O'Keefe (1980) was first to suggest that an Earth ring system could drive climate: a ring in the equatorial plane, waxing and waning in optical depth, could drive the alternation of Ice Age and interglacial climates. This driver would account for the observation that the Ice Age climate was mainly a difference in winter only. Could Earth have a ring system with one or both elements? Even if light and unstable, it would be important to assess, as it could drive climate change. Dust assessments have not discovered a ring system, but they do not cover low orbits well, nor rule out very small particles stringently. Yet tiny particles can be optically important. There are many difficulties with this hypothesis: Why have ground-based observers never identified an equatorial ring, which after all should be the brightest element of a ring system? Why should a ring system be made of very small particles only? The material must be constantly falling to Earth - where is it? Finally, can we believe in the level of lunar geological activity needed to sustain an Earth ring system? This presentation addresses only one issue: Could ground-based observers have seen but misidentified an equatorial ring? To support consideration of that question, herewith a simple geometric exercise: a schema of ring effects on the southern sky: (i) extinction of extra-terrestrial light between celestial equator and horizon; (ii) brightening of extra-terrestrial light via light-through-dust effects near the southern horizon; and (iii) reflection of sunlight from celestial equator to horizon. These effects would be modulated by season (due to ring self-shadowing) and hour of the night (because of Earth's shadow). We suggest that the expected effects are not "missing" at all - similar effects are well known to observers but are taken to be fully accounted for by skyglow, airglow and light pollution, qualitatively similar phenomena that certainly exist. We conclude that ground-based observers' non-identification of an equatorial ring is not a counter-indicator of a ring's existence. As far as this consideration goes, the question of an Earth ring system is open.

Planetary Rings

NASA Technical Reports Server (NTRS)

Cuzzi, Jeffrey N.

1994-01-01

Just over two decades ago, Jim Pollack made a critical contribution to our understanding of planetary ring particle properties, and resolved a major apparent paradox between radar reflection and radio emission observations. At the time, particle properties were about all there were to study about planetary rings, and the fundamental questions were, why is Saturn the only planet with rings, how big are the particles, and what are they made of? Since then, we have received an avalanche of observations of planetary ring systems, both from spacecraft and from Earth. Meanwhile, we have seen steady progress in our understanding of the myriad ways in which gravity, fluid and statistical mechanics, and electromagnetism can combine to shape the distribution of the submicron-to-several-meter size particles which comprise ring systems into the complex webs of structure that we now know them to display. Insights gained from studies of these giant dynamical analogs have carried over into improved understanding of the formation of the planets themselves from particle disks, a subject very close to Jim's heart. The now-complete reconnaissance of the gas giant planets by spacecraft has revealed that ring systems are invariably found in association with families of regular satellites, and there is ark emerging perspective that they are not only physically but causally linked. There is also mounting evidence that many features or aspects of all planetary ring systems, if not the ring systems themselves, are considerably younger than the solar system

O-Ring sealing arrangements for ultra-high vacuum systems

DOEpatents

Kim, Chang-Kyo; Flaherty, Robert

1981-01-01

An all metal reusable O-ring sealing arrangement for sealing two concentric tubes in an ultra-high vacuum system. An O-ring of a heat recoverable alloy such as Nitinol is concentrically positioned between protruding sealing rings of the concentric tubes. The O-ring is installed between the tubes while in a stressed martensitic state and is made to undergo a thermally induced transformation to an austenitic state. During the transformation the O-ring expands outwardly and contracts inwardly toward a previously sized austenitic configuration, thereby sealing against the protruding sealing rings of the concentric tubes.

Superfluid qubit systems with ring shaped optical lattices

PubMed Central

Amico, Luigi; Aghamalyan, Davit; Auksztol, Filip; Crepaz, Herbert; Dumke, Rainer; Kwek, Leong Chuan

2014-01-01

We study an experimentally feasible qubit system employing neutral atomic currents. Our system is based on bosonic cold atoms trapped in ring-shaped optical lattice potentials. The lattice makes the system strictly one dimensional and it provides the infrastructure to realize a tunable ring-ring interaction. Our implementation combines the low decoherence rates of neutral cold atoms systems, overcoming single site addressing, with the robustness of topologically protected solid state Josephson flux qubits. Characteristic fluctuations in the magnetic fields affecting Josephson junction based flux qubits are expected to be minimized employing neutral atoms as flux carriers. By breaking the Galilean invariance we demonstrate how atomic currents through the lattice provide an implementation of a qubit. This is realized either by artificially creating a phase slip in a single ring, or by tunnel coupling of two homogeneous ring lattices. The single qubit infrastructure is experimentally investigated with tailored optical potentials. Indeed, we have experimentally realized scaled ring-lattice potentials that could host, in principle, n ~ 10 of such ring-qubits, arranged in a stack configuration, along the laser beam propagation axis. An experimentally viable scheme of the two-ring-qubit is discussed, as well. Based on our analysis, we provide protocols to initialize, address, and read-out the qubit. PMID:24599096

Earth: A Ringed Planet?

NASA Astrophysics Data System (ADS)

Hancock, L. O.; Povenmire, H.

2010-12-01

Among the most beautiful findings of the Space Age have been the discoveries of planetary rings. Not only Saturn but also Jupiter, Uranus and Neptune have rings; Saturn’s ring system has structures newly discovered; even Saturn's moon Rhea itself has a ring. All these are apparently supplied by material from the planetary moons (Rhea's ring by Rhea itself). The question naturally arises, why should the Earth not have a ring, and on the other hand, if it does, why has it not been observed? No rings have yet been observed in the inner solar system, but after all, rings in the inner solar system might simply tend to be fainter and more transient than those of the outer solar system: the inner solar system is more affected by the solar wind, and the Sun’s perturbing gravitational influence is greater. J.A. O’Keefe first suggested (1980) that Earth might have a ring system of its own. An Earth ring could account for some climate events. O’Keefe remarked that formation or thickening of a ring system in Earth’s equatorial plane could drive glaciation by deepening the chill of the winter hemisphere. (It is very well established that volcanic dust is an effective agent for the extinction of sunlight; this factor can be overwhelmingly apparent in eclipse observations.) O’Keefe died in 2000 and the speculation was not pursued, but the idea of an Earth ring has a prima facie reasonableness that calls for its renewed consideration. The program of this note is to hypothesize that, as O’Keefe proposed: (a) an Earth ring system exists; (b) it affects Earth's weather and climate; (c) the tektite strewn fields comprise filaments of the ring fallen to Earth's surface on various occasions of disturbance by comets or asteroids. On this basis, and drawing on the world's weather records, together with the Twentieth Century Reanalysis by NCEP/CIRES covering the period 1870-2010 and the geology of the tektite strewn fields, we herein propose the hypothesized Earth ring system’s orbital elements and structure. Our work concludes that rings may exist in Earth’s equatorial plane and in the plane of the lunar orbit, that such rings are filamentary structures comprising segments of geologically homogeneous material flung into earth’s orbit at distinct periods of lunar volcanism, and that earth’s weather may indeed be very strongly affected by the rings. In closing, until the time of the lunar landing in 1969, the moon was considered geologically dead. But today, we have multiple lines of evidence that the Moon is still volcanically active. According to our study, this volcanism may affect weather and climate considerably. If lunar volcanism and weather on Earth are linked, then a satisfactory understanding of lunar volcanism is called for by considerations of human welfare. The subsistence farmer has an immediate need to know what is true about our Moon; food security depends on it.

Evolution of Planetary Ringmoon Systems

NASA Technical Reports Server (NTRS)

Cuzzi, Jeffrey N.

1995-01-01

The last few decades have seen an avalanche of observations of planetary ring systems, both from spacecraft and from Earth. Meanwhile, we have seen steady progress in our understanding of these systems as our intuition (and our computers) catch up with the myriad ways in which gravity, fluid and statistical mechanics, and electromagnetism can combine to shape the distribution of the submicron-to-several-meter size particles which comprise ring systems. The now-complete reconnaissance of the gas giant planets by spacecraft has revealed that ring systems are invariably found in association with families of regular satellites, and there is an emerging perspective that they are not only physically but causally linked. There is also mounting evidence that many features or aspects of all planetary ring systems, if not the ring systems themselves, are considerably younger than the solar system.

Planetary Rings

NASA Astrophysics Data System (ADS)

Gordon, M. K.; Araki, S.; Black, G. J.; Bosh, A. S.; Brahic, A.; Brooks, S. M.; Charnoz, S.; Colwell, J. E.; Cuzzi, J. N.; Dones, L.; Durisen, R. H.; Esposito, L. W.; Ferrari, C.; Festou, M.; French, R. G.; Giuliatti-Winter, S. M.; Graps, A. L.; Hamilton, D. P.; Horanyi, M.; Karjalainen, R. M.; Krivov, A. V.; Krueger, H.; Larson, S. M.; Levison, H. F.; Lewis, M. C.; Lissauer, J. J.; Murray, C. D.; Namouni, F.; Nicholson, P. D.; Olkin, C. B.; Poulet, F.; Rappaport, N. J.; Salo, H. J.; Schmidt, J.; Showalter, M. R.; Spahn, F.; Spilker, L. J.; Srama, R.; Stewart, G. R.; Yanamandra-Fisher, P.

2002-08-01

The past two decades have witnessed dramatic changes in our view and understanding of planetary rings. We now know that each of the giant planets in the Solar System possesses a complex and unique ring system. Recent studies have identified complex gravitational interactions between the rings and their retinues of attendant satellites. Among the four known ring systems, we see elegant examples of Lindblad and corotation resonances (first invoked in the context of galactic disks), electromagnetic resonances, spiral density waves and bending waves, narrow ringlets which exhibit internal modes due to collective instabilities, sharp-edged gaps maintained via tidal torques from embedded moonlets, and tenuous dust belts created by meteoroid impact onto, or collisions between, parent bodies. Yet, as far as we have come, our understanding is far from complete. The fundamental questions confronting ring scientists at the beginning of the twenty-first century are those regarding the origin, age and evolution of the various ring systems, in the broadest context. Understanding the origin and age requires us to know the current ring properties, and to understand the dominant evolutionary processes and how they influence ring properties. Here we discuss a prioritized list of the key questions, the answers to which would provide the greatest improvement in our understanding of planetary rings. We then outline the initiatives, missions, and other supporting activities needed to address those questions, and recommend priorities for the coming decade in planetary ring science.

Improved power steering with double and triple ring waveguide systems: the impact of the operating frequency.

PubMed

Kok, H P; de Greef, M; Borsboom, P P; Bel, A; Crezee, J

2011-01-01

Regional hyperthermia systems with 3D power steering have been introduced to improve tumour temperatures. The 3D 70-MHz AMC-8 system has two rings of four waveguides. The aim of this study is to evaluate whether T(90) will improve by using a higher operating frequency and whether further improvement is possible by adding a third ring. Optimised specific absorption rate (SAR) distributions were evaluated for a centrally located target in tissue-equivalent phantoms, and temperature optimisation was performed for five cervical carcinoma patients with constraints to normal tissue temperatures. The resulting T(90) and the thermal iso-effect dose (i.e. the number of equivalent min at 43°C) were evaluated and compared to the 2D 70-MHz AMC-4 system with a single ring of four waveguides. FDTD simulations were performed at 2.5 × 2.5 × 5 mm(3) resolution. The applied frequencies were 70, 100, 120, 130, 140 and 150 MHz. Optimised SAR distributions in phantoms showed an optimal SAR distribution at 140 MHz. For the patient simulations, an optimal increase in T(90) was observed at 130 MHz. For a two-ring system at 70 MHz the gain in T(90) was about 0.5°C compared to the AMC-4 system, averaged over the five patients. At 130 MHz the average gain in T(90) was ~1.5°C and ~2°C for a two and three-ring system, respectively. This implies an improvement of the thermal iso-effect dose with a factor ~12 and ~30, respectively. Simulations showed that a 130-MHz two-ring waveguide system yields significantly higher tumour temperatures compared to 70-MHz single-ring and double-ring waveguide systems. Temperatures were further improved with a 130-MHz triple-ring system.

Neptune - full ring system

NASA Technical Reports Server (NTRS)

1989-01-01

This pair of Voyager 2 images (FDS 11446.21 and 11448.10), two 591-s exposures obtained through the clear filter of the wide angle camera, show the full ring system with the highest sensitivity. Visible in this figure are the bright, narrow N53 and N63 rings, the diffuse N42 ring, and (faintly) the plateau outside of the N53 ring (with its slight brightening near 57,500 km).

Enriching screening libraries with bioactive fragment space.

PubMed

Zhang, Na; Zhao, Hongtao

2016-08-01

By deconvoluting 238,073 bioactive molecules in the ChEMBL library into extended Murcko ring systems, we identified a set of 2245 ring systems present in at least 10 molecules. These ring systems belong to 2221 clusters by ECFP4 fingerprints with a minimum intracluster similarity of 0.8. Their overlap with ring systems in commercial libraries was further quantified. Our findings suggest that success of a small fragment library is driven by the convergence of effective coverage of bioactive ring systems (e.g., 10% coverage by 1000 fragments vs. 40% by 2million HTS compounds), high enrichment of bioactive ring systems, and low molecular complexity enhancing the probability of a match with the protein targets. Reconciling with the previous studies, bioactive ring systems are underrepresented in screening libraries. As such, we propose a library of virtual fragments with key functionalities via fragmentation of bioactive molecules. Its utility is exemplified by a prospective application on protein kinase CK2, resulting in the discovery of a series of novel inhibitors with the most potent compound having an IC50 of 0.5μM and a ligand efficiency of 0.41kcal/mol per heavy atom. Copyright © 2016 Elsevier Ltd. All rights reserved.

[Design and Analysis of CT High-speed Data Transmission Rotating Connector Ring System Retaining Ring].

PubMed

Pan, Li; Cao, Jujiang; Liu, Min; Fu, Weiwei

2017-11-30

High speed data transmission rotating connector system for signal high-speed transmission used in the fixed end and rotating end, it is one of the core component in the CT system. This paper involves structure design and analysis of the retaining ring in the CT high speed data transmission rotating connector system based on the principle of off-axis free space optical transmission. According to the problem of the actual engineering application of space limitations, optical fiber fixed and collimator installation location, we designed the structure of the retaining ring. Using the static analysis function of ANSYS Workbench, it verifies rationality and safety of the strength of retaining ring structure. And based on modal analysis function of ANSYS Workbench, it evaluates the effect of the retaining ring on the stability of the system date transmission, and provides theoretical basis for the feasibility of the structure in practical application.

Planetary rings: Structure and history

NASA Astrophysics Data System (ADS)

Esposito, L.

The composition and structure of planetary rings provide the key evidence to understand their origin and evolution. Before the first space observations, we were able to maintain an idealized view of the rings around Saturn, the only known ring system at that time. Rings were then discovered around Jupiter, Uranus and Neptune. Saturn's F ring was discovered by Pioneer 11. Our ideal view of circular, planar, symmetric and unchanging rings was shattered by observations of inclined, eccentric rings, waves and wavy edges, and numerous processes acting at rates that give timescales much younger than the solar system. Moons within and near the rings sculpt them and are the likely progenitors of future rings. The moonlet lifetimes are much less than Saturn's age. The old idea of ancient rings gave rise to youthful rings, that are recently created by erosion and destruction of small nearby moons. Although this explanation may work well for most rings, Saturn's massive ring system provides a problem. It is extremely improbable that Saturn's rings were recently created by the destruction of a moon as large as Mimas, or even by the breakup of a large comet that passed too close to Saturn. The history of Saturn's rings has been a difficult problem, now made even more challenging by the close-up Cassini measurements. Cassini observations show unexpected ring variability in time and space. Time variations are seen in ring edges, in the thinner D and F rings, and in the neutral oxygen cloud, which outweighs the E ring in the same region around Saturn. The rings are inhomogeneous, with structures on all scales, sharp gradients and edges. Compositional gradients are sharper than expected, but nonetheless cross structural boundaries. This is evidence for ballistic transport that has not gone to completion. The autocovariance maximizes in the middle of the A ring, with smaller structure near the main rings' outer edge. Density wave locations have a fresher ice composition. The processes of collisions, diffusion and transport should have homogenized the rings over the age of the solar system. Instead, these differences persist. The mass density in the Cassini division inferred from density waves is so low, that the material there would be ground to 1 dust in 30,000 years. The observed moons that cause such interesting structure in the rings have short lifetimes against disruption by cometary bombardment and against the angular momentum transfers that push them away from the rings. These rapid processes evident in the Cassini data have been taken as evidence that the rings were recently created, perhaps from a comet that passed too close to Saturn. Instead, an alternative is that primordial material may have been re-used and recycled. In the zone near the Roche limit where rings are found, limited accretion is possible, with the larger bodies able to recapture smaller fragments. The `propeller' structures, the self-gravity wakes, and the size distribution of clumps in Saturn's F ring are all indications of the accretion process. Recycling could extend the ring lifetime almost indefinitely. The variety evident in the latest observations and the low mass density inferred for the largest bodies are both consistent with extensive recycling of ring material as the explanation of the apparent youth of Saturn's rings. Similar processes are likely occurring tin the other ring systems and in the formation of planets around other stars. 2

Results from a survey of the dynamics shaping Uranus' Mab/μ-ring system

NASA Astrophysics Data System (ADS)

Kumar, Kartik; de Pater, Imke; Showalter, Mark R.

2014-11-01

Based on Hubble Space Telescope (HST) data, Showalter and Lissauer (2006) reported the discovery of two faint rings beyond Uranus’ main rings: the ν- and μ- rings. They constitute Uranus' outer ring system and are located beyond the ɛ-ring but interior to the large classical moons. After co-adding a series of HST images, Showalter and Lissauer (2006) obtained radial profiles for both new rings. They discovered that the peak radial intensity of the μ-ring aligns closely with the orbit of Mab. Along with numerous other observations, this points to the fact that the Mab/μ-ring system is highly coupled.The discovery of the μ-ring has led to open questions about dust dynamics beyond Uranus' main rings. Like Saturn's E-ring, observations reveal that the μ-ring is blue, indicative of a pre-dominance of sub-micron-sized particles (de Pater et al., 2006). The E-ring results from plumes on Enceladus' south pole, however the origin of the μ-ring remains a mystery. The latter is likely fed by ejecta from micro-meteorite impacts with Mab, much like Jupiter's faint rings are regenerated by companion (small) moons (Burns et al., 1999). The μ-ring's steep size-distribution suggests that there is an unknown mechanism at play that hides or removes large dust particles. We present results from an investigation into the forces shaping the μ-ring. To simulate the motion of dust in the Mab/μ-ring system, we developed a numerical toolbox (Dustsim; Kumar et al., 2015) that uses Tudat (Kumar et al., 2012). We performed integrations using Dustsim that included the effects of Uranus' gravity field, titled magnetic moment, solar radiation pressure, and collisions with a putative suite of large μ-ring bodies, hypothesized as the cause of Mab's anomalous orbital motion (Kumar et al., 2014). Following on from previous studies (e.g., Sfair and Giuliatti Winter, 2009; Sfair and Giuliatti Winter, 2012), we present a survey of the expected lifetime of μ-ring dust, as a function of particle size. Our results lay the basis for further research into the hypothesis that the blueness of the μ-ring is a manifestation of size-based sorting, resulting from the natural environment.

Fan blade protection system

NASA Technical Reports Server (NTRS)

Hermans, Thomas C. (Inventor); Wakeman, Thomas G. (Inventor); Hauser, Ambrose A. (Inventor)

1993-01-01

In one type of aircraft propulsion system, propeller blades are mounted on a ring which surrounds a turbine. An annular space exists between the turbine and the ring. If a propeller blade should break free, the unbalanced centrifugal load tends to deform the ring. The invention reduces the deformation, as by locating spacers between the turbine and the ring.

Chinese Readers Can Perceive a Word Even When It's Composed of Noncontiguous Characters

ERIC Educational Resources Information Center

Ma, Guojie; Pollatsek, Alexander; Li, Yugang; Li, Xingshan

2017-01-01

This study explored whether readers could recognize a word composed of noncontiguous characters (a "cross-character word") in Chinese reading. All 3 experiments employed Chinese 4-character strings ABCD, where both AB and CD were 2-character words. In the cross-character word condition, AC was a word but in the control condition, AC was…

Doing Things Differently: Using the ABCD Method to Negotiate with Local Leaders in Community Engagement Projects

ERIC Educational Resources Information Center

Chinyowa, Kennedy C.; Sirayi, Mziwoxolo; Mokuku, Selloane

2016-01-01

The Laedza Batanani Project has been regarded as the pioneering experiment that paved the way for other prominent African Theatre for Development (TFD) projects such as Kamiriithu in Kenya, Murewa in Zimbabwe, Kumba in Cameroon and Marotholi Travelling Theatre in Lesotho. Laedza Batanani (1974-6) aimed at awakening the creative potential of…

Reduction of Salmonella Enteritidis in the spleens of hens by bacterins that vary in fimbrial protein SefD

USDA-ARS?s Scientific Manuscript database

Gene sefD is part of operon sefABCD, and it is required for production of the SEF14 fimbria by Salmonella Enteritidis. We compared strains that varied in SefD content for their ability to reduce recovery of Salmonella Enteritidis from the spleens of hens infected by parenteral challenge. The two bac...

Composite correlation filter for O-ring detection in stationary colored noise

NASA Astrophysics Data System (ADS)

Hassebrook, Laurence G.

2009-04-01

O-rings are regularly replaced in aircraft and if they are not replaced or if they are installed improperly, they can result in catastrophic failure of the aircraft. It is critical that the o-rings be packaged correctly to avoid mistakes made by technicians during routine maintenance. For this reason, fines may be imposed on the o-ring manufacturer if the o-rings are packaged incorrectly. That is, a single o-ring must be packaged and labeled properly. No o-rings or more than one o-ring per package is not acceptable. We present an industrial inspection system based on real-time composite correlation filtering that has successfully solved this problem in spite of opaque paper o-ring packages. We present the system design including the composite filter design.

High-level intuitive features (HLIFs) for intuitive skin lesion description.

PubMed

Amelard, Robert; Glaister, Jeffrey; Wong, Alexander; Clausi, David A

2015-03-01

A set of high-level intuitive features (HLIFs) is proposed to quantitatively describe melanoma in standard camera images. Melanoma is the deadliest form of skin cancer. With rising incidence rates and subjectivity in current clinical detection methods, there is a need for melanoma decision support systems. Feature extraction is a critical step in melanoma decision support systems. Existing feature sets for analyzing standard camera images are comprised of low-level features, which exist in high-dimensional feature spaces and limit the system's ability to convey intuitive diagnostic rationale. The proposed HLIFs were designed to model the ABCD criteria commonly used by dermatologists such that each HLIF represents a human-observable characteristic. As such, intuitive diagnostic rationale can be conveyed to the user. Experimental results show that concatenating the proposed HLIFs with a full low-level feature set increased classification accuracy, and that HLIFs were able to separate the data better than low-level features with statistical significance. An example of a graphical interface for providing intuitive rationale is given.

Melanoma detection using a mobile phone app

NASA Astrophysics Data System (ADS)

Diniz, Luciano E.; Ennser, K.

2016-03-01

Mobile phones have had their processing power greatly increased since their invention a few decades ago. As a direct result of Moore's Law, this improvement has made available several applications that were impossible before. The aim of this project is to develop a mobile phone app, integrated with its camera coupled to an amplifying lens, to help distinguish melanoma. The proposed device has the capability of processing skin mole images and suggesting, using a score system, if it is a case of melanoma or not. This score system is based on the ABCDE signs of melanoma, and takes into account the area, the perimeter and the colors present in the nevus. It was calibrated and tested using images from the PH2 Dermoscopic Image Database from Pedro Hispano Hospital. The results show that the system created can be useful, with an accuracy of up to 100% for malign cases and 80% for benign cases (including common and atypical moles), when used in the test group.

Planetary Ringmoon Systems

NASA Technical Reports Server (NTRS)

Cuzzi, J. N.; Morrison, David (Technical Monitor)

1994-01-01

The last decade has seen an avalanche of observations of planetary ring systems, both from spacecraft and from Earth. Much of the structure revealed was thoroughly puzzling and fired the imagination of workers in a variety of disciplines. Consequently, we have also seen steady progress in our understanding of these systems as our intuitions (and our computers) catch up with the myriad ways in which gravity, fluid and statistical mechanics, and electromagnetism can combine to shape the distribution of the submicron to-several-meter size particles which comprise ring systems (refs 1-5). The now-complete reconnaissance of the gas giant planets by spacecraft has revealed that ring systems and families of regular satellites are invariably found together, and there is an emerging perspective that they are not only physically but causally linked. There is also mounting evidence that many features or aspects of all planetary ring systems, if not the ring systems themselves, are considerably younger than the solar system.

Reciprocating down-hole sand pump

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ruhle, J.L.

1987-04-28

This patent describes the invention of a continuously-operated reciprocating down-hole sand pump comprising: a steel polished plunger pipe that strokes back and forth within a steel honed pump barrel, and is equipped with a self-lubricating fluorocarbon V-ring system that is pressure-actuated during compression strokes; the self-lubricating fluorocarbon V-ring system also is self-actuated by means of coil springs to provide wiping action to the polished plunger pipe during suction strokes; the self-lubricating fluorocarbons V-ring system also self-adjusts by means of coil springs located adjacent the fluorocarbon V-ring so as to automatically compensate for V-ring wear; and the self-lubricating fluorocarbon V-ring systemmore » also is designed in such a manner so as to eliminate voids and discourage the extrusion of V-rings in high temperature and high-pressure applications.« less

Voyager Saturnian ring measurements and the early history of the solar system

NASA Technical Reports Server (NTRS)

Alfven, H.; Axnaes, I.; Brenning, N.; Lindquist, P. A.

1985-01-01

The mass distribution in the Saturnian ring system is investigated and compared with predictions from plasma cosmogony. According to this theory, the matter in the rings was once a magnetized plasma, in which gravitation is balanced by the centrifugal and electromagnetic forces. As the plasma is neutralized, the electromagnetic forces disappear and the matter falls in to 2/3 of the original saturnocentric distance. This causes the cosmogonic shadow effect, demonstrated for the large scale structure of the Saturnian ring system. It is shown that many structures of the present ring system can be understood as shadows and antishadows of cosmogonic origin. These appear in the form of double rings centered around a position a factor 0.64 (slightly 2/3) closer to Saturn than the causing feature. Voyager data agree with an accuracy 1%.

Design of illumination system in ring field capsule endoscope

NASA Astrophysics Data System (ADS)

Jeng, Wei-De; Mang, Ou-Yang; Chen, Yu-Ta; Wu, Ying-Yi

2011-03-01

This paper is researching about the illumination system in ring field capsule endoscope. It is difficult to obtain the uniform illumination on the observed object because the light intensity of LED will be changed along its angular displacement and same as luminous intensity distribution curve. So we use the optical design software which is Advanced Systems Analysis Program (ASAP) to build a photometric model for the optimal design of LED illumination system in ring field capsule endoscope. In this paper, the optimal design of illumination uniformity in the ring field capsule endoscope is from origin 0.128 up to optimum 0.603 and it would advance the image quality of ring field capsule endoscope greatly.

Further explorations of cosmogonic shadow effects in the Saturnian rings

NASA Technical Reports Server (NTRS)

Alfven, H.; Axnaes, I.; Brenning, N.; Lindqvist, P. A.

1985-01-01

The mass distribution in the Saturnian ring system is compared with predictions from the cosmogonic theory of Alfven and Arrhenius (1975) in which matter in the rings was once a magnetized plasma, with gravitation balanced by centrifugal force and by the magnetic field. As the plasma is neutralized, the magnetic force disappears and the matter can be shown to fall in to a distance 2/3 of the original. This supports the cosmogonic shadow effect, also demonstrated for the astroidal belt and in the large scale structure of the Saturnian ring system. The relevance of the comogonic shadow effect for parts of the finer structures of the Saturnian ring system is investigated. It is shown that many structures of the present ring system can be understood as shadows and antishadows of cosmogonic origin. These appear in the form of double rings centered around a position a factor 0.64 (slightly 2/3) closer to Saturn than the causing feature.

Jupiter's ring system - New results on structure and particle properties

NASA Technical Reports Server (NTRS)

Showalter, Mark R.; Burns, Joseph A.; Cuzzi, Jeffrey N.; Pollack, James B.

1987-01-01

Jupiter's diffuse ring system is upon reexamination of Voyager images noted to be composed of a relatively bright narrow ring and an inner toroidal halo as well as the 'gossamer' exterior ring, while the previously suspected inner disk is missing. Several narrow, bright features are visible in the main ring, and are suggested to be related in some way to Adrastea and Metis. The smallest ring particles and the dark, rough, red largest bodies both have total optical depths of 1-6 x 10 to the -6th. After arising at the bright ring's inner boundary, the halo rapidly expands inward to a 20,000-km thickness, and disappears at a radius of 90,000 km halfway between the main ring and the planet's cloudtops.

One last look from the dark side: Cassini's final views of Saturn's rings from with the planet's shadow

NASA Astrophysics Data System (ADS)

Hedman, Matthew M.; Burns, Joseph A.; Nicholson, Philip D.; Tiscareno, Matthew S.; Evans, Michael W.; Baker, Emily

2017-10-01

Around the start of Cassini's Grand Finale, the spacecraft passed a dozen times through Saturn's shadow, enabling its cameras and spectrometers to observe the ring system at extremely high phase angles. These opportunities yielded the best combination of signal-to-noise and resolution for many parts of Saturn's fainter dusty rings, and allowed the main rings to be viewed from previously inaccessible lighting geometries. We will highlight some of the surprising features found in the data obtained by Cassini's Imaging Science Subsystem (ISS) and Visual and Infrared Mapping Spectrometer (VIMS) during these time periods, and discuss what they might be able to tell us about the structure and dynamics of Saturn's various ring systems. For example, ISS captured global views of the entire ring system that reveal previously unseen structures in dust-filled regions like the D ring and the zone between Saturn's F and G rings, as well as novel fine-scale structures in the core of the E ring near Enceladus' orbit. These structures provide new insights into the forces that sculpt these tenuous rings. ISS and VIMS also detected an unexpected brightening and highly unusual spectra of the main rings at extremely high phase angles. These data may provide novel information about the distribution of small grains and particles in these denser rings.

A pilot investigation to constrain the presence of ring systems around transiting exoplanets

NASA Astrophysics Data System (ADS)

Hatchett, W. Timothy; Barnes, Jason W.; Ahlers, John P.; MacKenzie, Shannon M.; Hedman, Matthew M.

2018-04-01

We demonstrate a process by which to evaluate the presence of large, Saturn-like ring systems around transiting extrasolar giant planets. We use extrasolar planet candidate KOI-422.01 as an example around which to establish limits on the presence of ring systems. We find that the spherical-planet (no-rings) fit matches the lightcurve of KOI-422.01 better than a lightcurve with a planet having obliquity angles 90°, 60°, 45°, or 20°. Hence we find no evidence for rings around KOI-422.01, but the methods that we have developed can be used for more comprehensive ring searches in the future. If the Hedman (2015) low-temperature rings hypothesis is correct, then the first positive detection of exorings might require transits of very long period ( ≳ 10 yr) giant planets outside their stars' ice lines.

Integration of RAM-SCB into the Space Weather Modeling Framework

DOE PAGES

Welling, Daniel; Toth, Gabor; Jordanova, Vania Koleva; ...

2018-02-07

We present that numerical simulations of the ring current are a challenging endeavor. They require a large set of inputs, including electric and magnetic fields and plasma sheet fluxes. Because the ring current broadly affects the magnetosphere-ionosphere system, the input set is dependent on the ring current region itself. This makes obtaining a set of inputs that are self-consistent with the ring current difficult. To overcome this challenge, researchers have begun coupling ring current models to global models of the magnetosphere-ionosphere system. This paper describes the coupling between the Ring current Atmosphere interaction Model with Self-Consistent Magnetic field (RAM-SCB) tomore » the models within the Space Weather Modeling Framework. Full details on both previously introduced and new coupling mechanisms are defined. Finally, the impact of self-consistently including the ring current on the magnetosphere-ionosphere system is illustrated via a set of example simulations.« less

Integration of RAM-SCB into the Space Weather Modeling Framework

DOE Office of Scientific and Technical Information (OSTI.GOV)

Welling, Daniel; Toth, Gabor; Jordanova, Vania Koleva

We present that numerical simulations of the ring current are a challenging endeavor. They require a large set of inputs, including electric and magnetic fields and plasma sheet fluxes. Because the ring current broadly affects the magnetosphere-ionosphere system, the input set is dependent on the ring current region itself. This makes obtaining a set of inputs that are self-consistent with the ring current difficult. To overcome this challenge, researchers have begun coupling ring current models to global models of the magnetosphere-ionosphere system. This paper describes the coupling between the Ring current Atmosphere interaction Model with Self-Consistent Magnetic field (RAM-SCB) tomore » the models within the Space Weather Modeling Framework. Full details on both previously introduced and new coupling mechanisms are defined. Finally, the impact of self-consistently including the ring current on the magnetosphere-ionosphere system is illustrated via a set of example simulations.« less

Discovery of multi-ring basins - Gestalt perception in planetary science

NASA Technical Reports Server (NTRS)

Hartmann, W. K.

1981-01-01

Early selenographers resolved individual structural components of multi-ring basin systems but missed the underlying large-scale multi-ring basin patterns. The recognition of multi-ring basins as a general class of planetary features can be divided into five steps. Gilbert (1893) took a first step in recognizing radial 'sculpture' around the Imbrium basin system. Several writers through the 1940's rediscovered the radial sculpture and extended this concept by describing concentric rings around several circular maria. Some reminiscences are given about the fourth step - discovery of the Orientale basin and other basin systems by rectified lunar photography at the University of Arizona in 1961-62. Multi-ring basins remained a lunar phenomenon until the fifth step - discovery of similar systems of features on other planets, such as Mars (1972), Mercury (1974), and possibly Callisto and Ganymede (1979). This sequence is an example of gestalt recognition whose implications for scientific research are discussed.

2-(Naphthalen-1-yl)-4-(naphthalen-1-yl­methyl­idene)-1,3-oxazol-5(4H)-one

PubMed Central

Gündoğdu, Cevher; Alp, Serap; Ergün, Yavuz; Tercan, Barış; Hökelek, Tuncer

2011-01-01

In the title compound, C24H15NO2, the oxazole ring is oriented at dihedral angles of 10.09 (4) and 6.04 (4)° with respect to the mean planes of the naphthalene ring systems, while the two naphthalene ring systems make a dihedral angle of 4.32 (3)°. Intra­molecular C—H⋯N hydrogen bonds link the oxazole N atom to the naphthalene ring systems. In the crystal, inter­molecular weak C—H⋯O hydrogen bonds link the mol­ecules into centrosymmetric dimers. π–π contacts between the oxazole and naphthalene rings and between the naphthalene ring systems [centroid–centroid distances = 3.5947 (9) and 3.7981 (9) Å] may further stabilize the crystal structure. Three weak C—H⋯π inter­actions also occur. PMID:21754548

The Complete Sequence and Comparative Analysis of a Multidrug-Resistance and Virulence Multireplicon IncFII Plasmid pEC302/04 from an Extraintestinal Pathogenic Escherichia coli EC302/04 Indicate Extensive Diversity of IncFII Plasmids.

PubMed

Ho, Wing Sze; Yap, Kien-Pong; Yeo, Chew Chieng; Rajasekaram, Ganeswrie; Thong, Kwai Lin

2015-01-01

Extraintestinal pathogenic Escherichia coli (ExPEC) that causes extraintestinal infections often harbor plasmids encoding fitness traits such as resistance and virulence determinants that are of clinical importance. We determined the complete nucleotide sequence of plasmid pEC302/04 from a multidrug-resistant E. coli EC302/04 which was isolated from the tracheal aspirate of a patient in Malaysia. In addition, we also performed comparative sequence analyses of 18 related IncFIIA plasmids to determine the phylogenetic relationship and diversity of these plasmids. The 140,232 bp pEC302/04 is a multireplicon plasmid that bears three replication systems (FII, FIA, and FIB) with subtype of F2:A1:B1. The plasmid is self-transmissible with a complete transfer region. pEC302/04 also carries antibiotic resistance genes such as bla TEM-1 and a class I integron containing sul1, cml and aadA resistance genes, conferring multidrug resistance (MDR) to its host, E. coli EC302/04. Besides, two iron acquisition systems (SitABCD and IutA-IucABCD) which are the conserved virulence determinants of ExPEC-colicin V or B and M (ColV/ColBM)-producing plasmids were identified in pEC302/04. Multiple toxin-antitoxin (TA)-based addiction systems (i.e., PemI/PemK, VagC/VagD, CcdA/CcdB, and Hok/Sok) and a plasmid partitioning system, ParAB, and PsiAB, which are important for plasmid maintenance were also found. Comparative plasmid analysis revealed only one conserved gene, the repA1 as the core genome, showing that there is an extensive diversity among the IncFIIA plasmids. The phylogenetic relationship of 18 IncF plasmids based on the core regions revealed that ColV/ColBM-plasmids and non-ColV/ColBM plasmids were separated into two distinct groups. These plasmids, which carry highly diverse genetic contents, are also mosaic in nature. The atypical combination of genetic materials, i.e., the MDR- and ColV/ColBM-plasmid-virulence encoding regions in a single ExPEC plasmid is rare but of clinical importance. Such phenomenon is bothersome when the plasmids are transmissible, facilitating the spread of virulence and resistance plasmids among pathogenic bacteria. Notably, certain TA systems are more commonly found in particular ExPEC plasmid types, indicating the possible relationships between certain TA systems and ExPEC pathogenesis.

Rings Research in the Next Decade

NASA Astrophysics Data System (ADS)

Tiscareno, Matthew S.; Albers, N.; Brahic, A.; Brooks, S. M.; Burns, J. A.; Chavez, C.; Colwell, J. E.; Cuzzi, J. N.; de Pater, I.; Dones, L.; Durisen, R. H.; Filacchione, G.; Giuliatti Winter, S. M.; Gordon, M. K.; Graps, A.; Hamilton, D. P.; Hedman, M. M.; Horanyi, M.; Kempf, S.; Krueger, H.; Lewis, M. C.; Lissauer, J. J.; Murray, C. D.; Nicholson, P. D.; Olkin, C. B.; Pappalardo, R. T.; Salo, H.; Schmidt, J.; Showalter, M. R.; Spahn, F.; Spilker, L. J.; Srama, R.; Sremcevic, M.; Stewart, G. R.; Yanamandra-Fisher, P.

2009-12-01

The study of planetary ring systems is a key component of planetary science for several reasons: 1) The evolution and current states of planets and their satellites are affected in many ways by rings, while 2) conversely, properties of planets and moons and other solar system populations are revealed by their effects on rings; 3) highly structured and apparently delicate ring systems may be bellwethers, constraining various theories of the origin and evolution of their entire planetary system; and finally, 4) planetary rings provide an easily observable analogue to other astrophysical disk systems, enabling real "ground truth” results applicable to disks much more remote in space and/or time, including proto-planetary disks, circum-stellar disks, and even galaxies. Significant advances have been made in rings science in the past decade. The highest-priority rings research recommendations of the last Planetary Science Decadal Survey were to operate and extend the Cassini orbiter mission at Saturn; this has been done with tremendous success, accounting for much of the progress made on key science questions, as we will describe. Important progress in understanding the rings of Saturn and other planets has also come from Earth-based observational and theoretical work, again as prioritized by the last Decadal Survey. However, much important work remains to be done. At Saturn, the Cassini Solstice Mission must be brought to a successful completion. Priority should also be placed on sending spacecraft to Neptune and/or Uranus, now unvisited for more than 20 years. At Jupiter and Pluto, opportunities afforded by visiting spacecraft capable of studying rings should be exploited. On Earth, the need for continued research and analysis remains strong, including in-depth analysis of rings data already obtained, numerical and theoretical modeling work, laboratory analysis of materials and processes analogous to those found in the outer solar system, and continued Earth-based observations.

Annular ring zoom system using two positive axicons

NASA Astrophysics Data System (ADS)

Dickey, Fred M.; Conner, Jacob D.

2011-10-01

The production of an annular ring of light with a variable diameter has applications in laser material processing and machining, particle manipulation, and corneal surgery. This can readily be accomplished using a positive and negative axicon pair. However, negative axicons are very expensive and difficult to obtain with small diameters. In this paper, we present a design of an annular ring zoom system using two positive axicons. One axicon is placed a distance before a primary lens that is greater than some prescribed minimum, and the second axicon is placed after the primary lens. The position of the second axicon determines the ring diameter. The ring diameter can be zoomed from some maximum design size to a zero diameter ring (spot). Experimental results from a developmental system will be presented.

The Search for Ringed Exoplanets

NASA Astrophysics Data System (ADS)

Kohler, Susanna

2017-04-01

Are planetary rings as common in our galaxy as they are in our solar system? A new study demonstrates how we might search for ringed exoplanets and then possibly finds one!Saturns Elsewhere?Artists illustration of the super ring system around exoplanet J1407b. This is the only exoplanet weve found with rings, but its not at all like Saturn. [Ron Miller]Our solar system is filled with moons and planetary rings, so it stands to reason that exoplanetary systems should exhibit the same features. But though weve been in the planet-hunting game for decades, weve only found one exoplanet thats surrounded by a ring system. Whats more, that system J1407b has enormous rings that are vastly different from the modest, Saturn-like rings that we might expect to be more commonplace.Have we not discovered ringed exoplanets just because theyre hard to identify? Or is it because theyre not out there? A team of scientists led by Masataka Aizawa (University of Tokyo) has set out to answer this question by conducting a systematic search for rings around long-period planet candidates.The transit light curve of KIC 10403228, shown with three models: the best-fitting planet-only model (blue) and the two best-fitting planet+ring models (green and red). [Aizawa et al. 2017]The Hunt BeginsWhy long-period planets? Rings are expected to be unstable as the planet gets closer to the central star. Whats more, the planet needs to be far enough away from the stars warmth for the icy rings to exist. The authors therefore select from the collection of candidate transiting planets 89 long-period candidates that might be able to host rings.Aizawa and collaborators then fit single-planet models (with no rings) to the light curves of these planets and search for anomalies curves that arent fit well by these standard models. Particularly suspicious characteristics include a long ingress/egress as the planet moves across the face of the star, and asymmetry of the transit shape.After applying a series of checks to eliminate false positives, the authors are left with one candidate: KIC 10403228.Rings or Not?Schematics of the two best-fitting ringed-exoplanet models for KIC 10403228, and the possible parameters of the system. The planet crosses the disk of the star from left to right with a grazing transit. [Adapted from Aizawa et al. 2017]Next, the authors apply a wide range of ringed-exoplanet models to KIC 10403228s light curve. They find two different scenarios that fit the data well: one in which the ring is significantly tilted with respect to the orbital plane, and another in which its only slightly tilted.The authors conclude by testing a variety of other scenarios that could explain the anomalies in the light curve instead. They find that two other scenarios are plausible: 1) the star is in an eclipsing binary system, with the second star surrounded by a circumstellar disk, and 2) the star is part of a hierarchical triple, and the transits are caused by a binary star system as it orbits KIC 10403228.Though Aizawa and collaborators arent able to rule either of these other two scenarios out, they suggest that follow-up spectroscopy or high-resolution imaging may help distinguish between the different scenarios. In the meantime, their methodology for systematically searching for ringed exoplanets has proven worthwhile, and they plan to extend it now to a larger data set. Perhaps well soon find other Saturn-like planets in our galaxy!CitationMasataka Aizawa () et al 2017 AJ 153 193. doi:10.3847/1538-3881/aa6336

14 CFR 217.10 - Instructions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... and the other pertaining to on-flight markets. For example, the routing (A-B-C-D) consists of three..., Singapore A-3—Airport code Origin A-4—Airport code Destination A-5—Service class (mark an X) F G L P Q By aircraft type— B-1—Aircraft type code B-2—Revenue aircraft departures B-3—Revenue passengers transported B...

14 CFR 217.10 - Instructions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... and the other pertaining to on-flight markets. For example, the routing (A-B-C-D) consists of three..., Singapore A-3—Airport code Origin A-4—Airport code Destination A-5—Service class (mark an X) F G L P Q By aircraft type— B-1—Aircraft type code B-2—Revenue aircraft departures B-3—Revenue passengers transported B...

14 CFR 217.10 - Instructions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... and the other pertaining to on-flight markets. For example, the routing (A-B-C-D) consists of three..., Singapore A-3—Airport code Origin A-4—Airport code Destination A-5—Service class (mark an X) F G L P Q By aircraft type— B-1—Aircraft type code B-2—Revenue aircraft departures B-3—Revenue passengers transported B...

A Derived Relations Analysis of Approach-Avoidance Conflict: Implications for the Behavioral Analysis of Human Anxiety

ERIC Educational Resources Information Center

Gannon, Steven; Roche, Bryan; Kanter, Jonathan W.; Forsyth, John P.; Linehan, Conor

2011-01-01

The current article reports two experiments designed to examine the effects of creating competing approach and avoidance response functions for 2 stimuli that participate in the same derived stimulus relation. Experiment 1 involved establishing each of 2 distinct members (i.e., B1 and D1) of the same 1-node equivalence relation (A-B-C-D) as a…

Interviewing Parents for Qualitative Research Studies: Using an ABCD Model to Manage the Sensitivities and Issues

ERIC Educational Resources Information Center

Price, Jayne; Nicholl, Honor

2013-01-01

Parenting a child with complex health/palliative care needs is wide ranging. Family-centred practices place parents at the heart of the ongoing care of these children, and therefore it makes sense that their views and experiences should be central to research within the field. Despite this assertion, little guidance exists as to how best to…

Improved piston ring materials for 650 deg C service

NASA Technical Reports Server (NTRS)

Bjorndahl, W. D.

1986-01-01

A program to develop piston ring material systems which will operate at 650C was performed. In this program, two candidate high temperature piston ring substrate materials, Carpenter 709-2 and 440B, were hot formed into the piston ring shape and subsequently evaluated. In a parallel development effort ceramic and metallic piston ring coating materials were applied to cast iron rings by various processing techniques and then subjected to thermal shock and wear evaluation. Finally, promising candidate coatings were applied to the most thermally stable hot formed substrate. The results of evaluation tests of the hot formed substrate show that Carpenter 709-2 has greater thermal stability than 440B. Of the candidate coatings, plasma transferred arc (PTA) applied tungsten carbide and molybdenum based systems exhibit the greatest resistance to thermal shock. For the ceramic based systems, thermal shock resistance was improved by bond coat grading. Wear testing was conducted to 650C (1202F). For ceramic systems, the alumina/titania/zirconia/yttria composition showed highest wear resistance. For the PTA applied systems, the tungsten carbide based system showed highest wear resistance.

Automatic flatness detection system for micro part

NASA Astrophysics Data System (ADS)

Luo, Yi; Wang, Xiaodong; Shan, Zhendong; Li, Kehong

2016-01-01

An automatic flatness detection system for micro rings is developed. It is made up of machine vision module, ring supporting module and control system. An industry CCD camera with the resolution of 1628×1236 pixel, a telecentric with magnification of two, and light sources are used to collect the vision information. A rotary stage with a polished silicon wafer is used to support the ring. The silicon wafer provides a mirror image and doubles the gap caused by unevenness of the ring. The control system comprise an industry computer and software written in LabVIEW Get Kernel and Convolute Function are selected to reduce noise and distortion, Laplacian Operator is used to sharp the image, and IMAQ Threshold function is used to separate the target object from the background. Based on this software, system repeating precision is 2.19 μm, less than one pixel. The designed detection system can easily identify the ring warpage larger than 5 μm, and if the warpage is less than 25 μm, it can be used in ring assembly and satisfied the final positionary and perpendicularity error requirement of the component.

2,4 Diamino benzonitrile

NASA Technical Reports Server (NTRS)

Frost, Lawrence W. (Inventor)

1980-01-01

Deep curable polymers having heterocyclic ring systems such as isoindoloquinazolinedione ring systems prepared from novel cyanoimide polymers, most desirably 2'-cyanoimide polymers. Preferably the cyanoimide polymers are prepared from a diamine having at least one nitrile group in the two position to an amine group and a dianhydride having at least two cyclic anhydride groups. Copolymers may be prepared having other linkages, notably imide linkages, in addition to isoindoloquinazolinedione ring systems and/or other similar heterocyclic ring systems. The copolymers can be prepared by use of diamines containing one or more cyanoimide groupings and/or imide groups in their structure.

Methyl 6-eth-oxy-3-phenyl-3a,4-dihydro-3H-chromeno[4,3-c]isoxazole-3a-car-boxylate.

PubMed

Suresh, G; Srinivasan, J; Bakthadoss, M; Aravindhan, S

2013-02-01

In the title compound, C(20)H(19)NO(5), the dihedral angle between the mean plane of the pyran ring (which has a half-chair conformation) and the benzene ring of the chromeno ring system is 7.21 (7)°. The dihedral angle between the mean plane of the chromeno ring system and the isoxazole ring is 21.78 (6)°, while the isoxazole ring forms a dihedral angle of 72.60 (8)° with the attached phenyl ring. In the crystal, mol-ecules are linked via pairs of C-H⋯O hydrogen bonds, forming inversion dimers with an R(2) (2)(10) ring motif. These dimers are linked via C-H⋯N hydrogen bonds, forming chains along [001].

Coherence resonance and stochastic resonance in directionally coupled rings

NASA Astrophysics Data System (ADS)

Werner, Johannes Peter; Benner, Hartmut; Florio, Brendan James; Stemler, Thomas

2011-11-01

In coupled systems, symmetry plays an important role for the collective dynamics. We investigate the dynamical response to noise with and without weak periodic modulation for two classes of ring systems. Each ring system consists of unidirectionally coupled bistable elements but in one class, the number of elements is even while in the other class the number is odd. Consequently, the rings without forcing show at a certain coupling strength, either ordering (similar to anti-ferromagnetic chains) or auto-oscillations. Analysing the bifurcations and fixed points of the two ring classes enables us to explain the dynamical response measured to noise and weak modulation. Moreover, by analysing a simplified model, we demonstrate that the response is universal for systems having a directional component in their stochastic dynamics in phase space around the origin.

An approach to develop an algorithm to detect the climbing height in radial-axial ring rolling

NASA Astrophysics Data System (ADS)

Husmann, Simon; Hohmann, Magnus; Kuhlenkötter, Bernd

2017-10-01

Radial-axial ring rolling is the mainly used forming process to produce seamless rings, which are applied in miscellaneous industries like the energy sector, the aerospace technology or in the automotive industry. Due to the simultaneously forming in two opposite rolling gaps and the fact that ring rolling is a mass forming process, different errors could occur during the rolling process. Ring climbing is one of the most occurring process errors leading to a distortion of the ring's cross section and a deformation of the rings geometry. The conventional sensors of a radial-axial rolling machine could not detect this error. Therefore, it is a common strategy to roll a slightly bigger ring, so that random occurring process errors could be reduce afterwards by removing the additional material. The LPS installed an image processing system to the radial rolling gap of their ring rolling machine to enable the recognition and measurement of climbing rings and by this, to reduce the additional material. This paper presents the algorithm which enables the image processing system to detect the error of a climbing ring and ensures comparable reliable results for the measurement of the climbing height of the rings.

Variable diameter CO₂ laser ring-cutting system adapted to a zoom microscope for applications on polymer tapes.

PubMed

Förster, Erik; Bohnert, Patrick; Kraus, Matthias; Kilper, Roland; Müller, Ute; Buchmann, Martin; Brunner, Robert

2016-11-20

This paper presents the conception and implementation of a variable diameter ring-cutting system for a CO₂ laser with a working wavelength of 10.6 μm. The laser-cutting system is adapted to an observation zoom microscope for combined use and is applicable for the extraction of small circular areas from polymer films, such as forensic adhesive tapes in a single shot. As an important characteristic for our application, the variable diameter ring-cutting system provides telecentricity in the target area. Ring diameters are continuously tunable between 500 μm and 2 mm. A minimum width of less than 20 μm was found for the ring profile edge. The basic characteristics of the system, including telecentricity, were experimentally evaluated and demonstrated by cutting experiments on different polymer tapes and further exemplary samples.

A Herschel-Resolved Debris Disk Around the Nearby G Star HIP 32480

NASA Technical Reports Server (NTRS)

Stapelfeldt, K.

2011-01-01

The Herschel Space Observatory is providing unprecedented sensitivity and angular resolution in the far-infrared. The DUNES Key Project (DUst around NEarby Stars, PI Carlos Eiroa) has finished its survey of 133 FGK stars within 25 pc of the Sun using the PACS photometer at 100 and 160 microns. We report the detection of a resolved debris ring around HIP 32480, a G0 star 16.5 parsecs distant. The ring is almost 300 AU in diameter and inclined 30 degrees from edge-on. We present a thermal emission model for the system that fits the Spitzer spectroscopy and Herschel images of the system. We find a minimum grainsize of approximately 4 microns in the main ring and a distinct warm dust population interior to it. Faint detached emission features just outside the ring may trace a separate, more distant ring in the system. The non-detection of the ring in archival HST/ACS coronagraphic images limits the dust grain albedo in the ring to be no more than 10%.

A Resolved Debris Disk Around the Nearby G Star HIP 32480

NASA Technical Reports Server (NTRS)

Stapelfeldt, K. R.; Bryden, G. C.; Marshall, J.; Eiroa, C.; Absil, O.; Mora, A.; Krist, J. E.; Su, K. Y. L.

2012-01-01

The Herschel Space Observatory is providing unprecedented sensitivity and angular resolution in the far-infrared. The DUNES Key Project (DUst around NEarby Stars, PI Carlos Eiroa) has finished its survey of 133 FGK stars within 25 pc of the Sun using the PACS photometer at 100 and 160 microns. We report the detection of a resolved debris ring around HIP 32480, a GO star 16.5 parsecs distant. The ring is almost 300 AU in diameter and inclined 30 degrees from edge-on. We present a thermal emission model for the system that fits the Spitzer spectroscopy and Herschel images of the system. We find a minimum grain-size of 4 microns in the main ring and a distinct warm dust population interior to it. Faint detached emission features just outside the ring may trace a separate, more distant ring in the system. The non-detection of the ring in archival HST/ACS coronagraphic images limits the dust grain albedo in the ring to be no more than 10%.

Uranus Ring System

NASA Image and Video Library

1996-01-29

This image captured by NASA's Voyager 2 in 1986 revealed a continuous distribution of small particles throughout the Uranus ring system. This unique geometry, the highest phase angle at which Voyager imaged the rings, allowed us to see lanes of fine dust. http://photojournal.jpl.nasa.gov/catalog/PIA00142

Mechanical evaluation of aluminum alloy ring fixator.

PubMed

Tosborvorn, Somboon; Cheechareon, Sukrom; Ruttanuchun, Kittiput; Sirivedin, Suparerk; Rhienumporn, Chaitawat

2006-11-01

To test the homemade ring fixator as a tool for correction of bony deformity. The authors developed an aluminum alloy ring fixator and tested it to find out the accuracy of manufacturing and strength of the ring systems under axial load with the Roundness Testing Machine and Lloyd Universal Testing Machine. The mean diameter of the twenty five-drill holes was 6.5843872 +/- 0.0521594 mm (mean +/- SD). Distance between particular drill holes, which reflected the precision of drilling, had a high accuracy with standard deviation from 0.1138 to 0.1870 mm. The roundness of the rings was 0.2421376 +/- 0.12437977 mm (mean +/- SD). The system structure had minimal permanent deformity at breaking point, mean yield strength of the system was 4786.9 +/- 14.353 N (mean +/- SD). This was caused by the failure of the wire. Mean stiffness of the system was 127 N./mm. The aluminum alloy ring fixator was strong enough and well tolerated for clinical usage

ARC-1989-A89-7042

NASA Image and Video Library

1989-08-11

P-34578 BW One of two new ring arcs, or partial rings, discovered by Voyager 2, is faintly visible just outside the orbit of the Neptunian moon 1989N4.The 155-second exposure taken by the spacecraft's narrow-angle camera shows the glare of an overexposed Neptune to the right of the moon and ring arc. The two bright streaks below the moon and ring arc are stars. The ring arc is approximately 50,000 kilometers (30,000 miles) long. The second ring arc, not apparent here, is about 10,000 kilometers (6,000 miles) long and is assoiciated with moon 1989N3. The ring arc, along with 1989N4, orbits about 62,000 kilometers (38,000 miles) from the planet's cloud tops. Astronomers long suspected the existence of such an irregular ring system around Neptune. Data from repeated ground-based observations hinted at the existence of irregular strands of partial rings orbiting Neptune. Voyager's photographs of the ring arcs are the first photographic evidence that such a ring system exists. Voyager scientists said the ring arcs may be comprised of debris associated with the nearby moons, or may be the remnants of moons that have been torn apart or ground down through collisions. Close-up studies of the ring arcs by Voyager 2 will help determine their composition.

Numerical study on the lubrication performance of compression ring-cylinder liner system with spherical dimples

PubMed Central

Liu, Cheng; Zhang, Yong-Fang; Li, Sha; Müller, Norbert

2017-01-01

The effects of surface texture on the lubrication performance of a compression ring-cylinder liner system are studied in this paper. By considering the surface roughness of the compression ring and cylinder liner, a mixed lubrication model is presented to investigate the tribological behaviors of a barrel-shaped compression ring-cylinder liner system with spherical dimples on the liner. In order to determine the rupture and reformulation positions of fluid film accurately, the Jacoboson-Floberg-Olsson (JFO) cavitation boundary condition is applied to the mixed lubrication model for ensuring the mass-conservative law. On this basis, the minimum oil film thickness and average friction forces in the compression ring-cylinder liner system are investigated under the engine-like conditions by changing the dimple area density, radius, and depth. The wear load, average friction forces, and power loss of the compression ring-cylinder liner system with and without dimples are also compared for different compression ring face profiles. The results show that the spherical dimples can produce a larger reduction of friction in mixed lubrication region, and reduce power loss significantly in the middle of the strokes. In addition, higher reduction percentages of average friction forces and wear are obtained for smaller crown height or larger axial width. PMID:28732042

A ring system detected around the Centaur (10199) Chariklo.

PubMed

Braga-Ribas, F; Sicardy, B; Ortiz, J L; Snodgrass, C; Roques, F; Vieira-Martins, R; Camargo, J I B; Assafin, M; Duffard, R; Jehin, E; Pollock, J; Leiva, R; Emilio, M; Machado, D I; Colazo, C; Lellouch, E; Skottfelt, J; Gillon, M; Ligier, N; Maquet, L; Benedetti-Rossi, G; Ramos Gomes, A; Kervella, P; Monteiro, H; Sfair, R; El Moutamid, M; Tancredi, G; Spagnotto, J; Maury, A; Morales, N; Gil-Hutton, R; Roland, S; Ceretta, A; Gu, S-h; Wang, X-b; Harpsøe, K; Rabus, M; Manfroid, J; Opitom, C; Vanzi, L; Mehret, L; Lorenzini, L; Schneiter, E M; Melia, R; Lecacheux, J; Colas, F; Vachier, F; Widemann, T; Almenares, L; Sandness, R G; Char, F; Perez, V; Lemos, P; Martinez, N; Jørgensen, U G; Dominik, M; Roig, F; Reichart, D E; LaCluyze, A P; Haislip, J B; Ivarsen, K M; Moore, J P; Frank, N R; Lambas, D G

2014-04-03

Hitherto, rings have been found exclusively around the four giant planets in the Solar System. Rings are natural laboratories in which to study dynamical processes analogous to those that take place during the formation of planetary systems and galaxies. Their presence also tells us about the origin and evolution of the body they encircle. Here we report observations of a multichord stellar occultation that revealed the presence of a ring system around (10199) Chariklo, which is a Centaur--that is, one of a class of small objects orbiting primarily between Jupiter and Neptune--with an equivalent radius of 124 ±  9 kilometres (ref. 2). There are two dense rings, with respective widths of about 7 and 3 kilometres, optical depths of 0.4 and 0.06, and orbital radii of 391 and 405 kilometres. The present orientation of the ring is consistent with an edge-on geometry in 2008, which provides a simple explanation for the dimming of the Chariklo system between 1997 and 2008, and for the gradual disappearance of ice and other absorption features in its spectrum over the same period. This implies that the rings are partly composed of water ice. They may be the remnants of a debris disk, possibly confined by embedded, kilometre-sized satellites.

Two-mode division multiplexing in a silicon-on-insulator ring resonator.

PubMed

Dorin, Bryce A; Ye, Winnie N

2014-02-24

Mode-division multiplexing (MDM) is an emerging multiple-input multiple-output method, utilizing multimode waveguides to increase channel numbers. In the past, silicon-on-insulator (SOI) devices have been primarily focused on single-mode waveguides. We present the design and fabrication of a two-mode SOI ring resonator for MDM systems. By optimizing the device parameters, we have ensured that each mode is treated equally within the ring. Using adiabatic Bezier curves in the ring bends, our ring demonstrated a signal-to-crosstalk ratio above 18 dB for both modes at the through and drop ports. We conclude that the ring resonator has the potential for filtering and switching for MDM systems on SOI.

[German adaptation of the "Activities-Specific Balance Confidence (ABC) scale" for the assessment of falls-related self-efficacy].

PubMed

Schott, Nadja

2008-12-01

The present study investigates the psychometric properties and the factorial structure of the German adaptation of the Activities-Specific Balance Confidence (ABC) scale (Powell & Myers, 1995) for the evaluation of falls-related self-efficacy in community-dwelling older adults. The German adaptation of the ABC using a forward-backward procedure was administered to 113 older adults (age 68.9+/-8.5 years). The following internationally accepted instruments were used for validation: The Short Form Health Survey SF 36, the Geriatric Depression Scale (GDS), the Trail Making Test and the Letter Number Sequencing Test, and motor tests (balance, strength, mobility). The internal consistency (0.91-0.95) as well as the test-retest reliability of the subscales was excellent (0.94-0.98). The correlation coefficients with the validation instruments ranged between 0.33 and 0.58. Significant differences in the ABC-D scores were found in older adults with and without falls. Older adults with a recent fall history scored lower on the ABC-D than older adults without a recent fall history. To conclude, the German version of the ABC has properties analogous to the original English version and is apparently useful in assessing falls-related self-efficacy.

A novel ABCD1 mutation detected by next generation sequencing in presumed hereditary spastic paraplegia: A 30-year diagnostic delay caused by misleading biochemical findings.

PubMed

Koutsis, Georgios; Lynch, David S; Tucci, Arianna; Houlden, Henry; Karadima, Georgia; Panas, Marios

2015-08-15

To present a Greek family in which 5 male and 2 female members developed progressive spastic paraplegia. Plasma very long chain fatty acids (VLCFA) were reportedly normal at first testing in an affected male and for over 30 years the presumed diagnosis was hereditary spastic paraplegia (HSP). Targeted next generation sequencing (NGS) was used as a further diagnostic tool. Targeted exome sequencing in the proband, followed by Sanger sequencing confirmation; mutation segregation testing in multiple family members and plasma VLCFA measurement in the proband. NGS of the proband revealed a novel frameshift mutation in ABCD1 (c.1174_1178del, p.Leu392Serfs*7), bringing an end to diagnostic uncertainty by establishing the diagnosis of adrenomyeloneuropathy (AMN), the myelopathic phenotype of X-linked adrenoleukodystrophy (ALD). The mutation segregated in all family members and the diagnosis of AMN/ALD was confirmed by plasma VLCFA measurement. Confounding factors that delayed the diagnosis are presented. This report highlights the diagnostic utility of NGS in patients with undiagnosed spastic paraplegia, establishing a molecular diagnosis of AMN, allowing proper genetic counseling and management, and overcoming the diagnostic delay that can be rarely caused by false negative VLCFA analysis. Copyright © 2015 Elsevier B.V. All rights reserved.

Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation.

PubMed

Ducka, Anna M; Joel, Peteranne; Popowicz, Grzegorz M; Trybus, Kathleen M; Schleicher, Michael; Noegel, Angelika A; Huber, Robert; Holak, Tad A; Sitar, Tomasz

2010-06-29

Three classes of proteins are known to nucleate new filaments: the Arp2/3 complex, formins, and the third group of proteins that contain ca. 25 amino acid long actin-binding Wiskott-Aldrich syndrome protein homology 2 domains, called the WH2 repeats. Crystal structures of the complexes between the actin-binding WH2 repeats of the Spire protein and actin were determined for the Spire single WH2 domain D, the double (SpirCD), triple (SpirBCD), quadruple (SpirABCD) domains, and an artificial Spire WH2 construct comprising three identical D repeats (SpirDDD). SpirCD represents the minimal functional core of Spire that can nucleate actin filaments. Packing in the crystals of the actin complexes with SpirCD, SpirBCD, SpirABCD, and SpirDDD shows the presence of two types of assemblies, "side-to-side" and "straight-longitudinal," which can serve as actin filament nuclei. The principal feature of these structures is their loose, open conformations, in which the sides of actins that normally constitute the inner interface core of a filament are flipped inside out. These Spire structures are distant from those seen in the filamentous nuclei of Arp2/3, formins, and in the F-actin filament.

Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation

PubMed Central

Ducka, Anna M.; Joel, Peteranne; Popowicz, Grzegorz M.; Trybus, Kathleen M.; Schleicher, Michael; Noegel, Angelika A.; Huber, Robert; Holak, Tad A.; Sitar, Tomasz

2010-01-01

Three classes of proteins are known to nucleate new filaments: the Arp2/3 complex, formins, and the third group of proteins that contain ca. 25 amino acid long actin-binding Wiskott-Aldrich syndrome protein homology 2 domains, called the WH2 repeats. Crystal structures of the complexes between the actin-binding WH2 repeats of the Spire protein and actin were determined for the Spire single WH2 domain D, the double (SpirCD), triple (SpirBCD), quadruple (SpirABCD) domains, and an artificial Spire WH2 construct comprising three identical D repeats (SpirDDD). SpirCD represents the minimal functional core of Spire that can nucleate actin filaments. Packing in the crystals of the actin complexes with SpirCD, SpirBCD, SpirABCD, and SpirDDD shows the presence of two types of assemblies, “side-to-side” and “straight-longitudinal,” which can serve as actin filament nuclei. The principal feature of these structures is their loose, open conformations, in which the sides of actins that normally constitute the inner interface core of a filament are flipped inside out. These Spire structures are distant from those seen in the filamentous nuclei of Arp2/3, formins, and in the F-actin filament. PMID:20538977

Computer-automated ABCD versus dermatologists with different degrees of experience in dermoscopy.

PubMed

Piccolo, Domenico; Crisman, Giuliana; Schoinas, Spyridon; Altamura, Davide; Peris, Ketty

2014-01-01

Dermoscopy is a very useful and non-invasive technique for in vivo observation and preoperative diagnosis of pigmented skin lesions (PSLs) inasmuch as it enables analysis of surface and subsurface structures that are not discernible to the naked eye. The authors used the ABCD rule of dermoscopy to test the accuracy of melanoma diagnosis with respect to a panel of 165 PSLs and the intra- and inter-observer diagnostic agreement obtained between three dermatologists with different degrees of experience, one General Practitioner and a DDA for computer-assisted diagnosis (Nevuscreen(®), Arkè s.a.s., Avezzano, Italy). 165 Pigmented Skin Lesions from 165 patients were selected. Histopathological examination revealed 132 benign melanocytic skin lesions and 33 melanomas. The kappa statistic, sensitivity, specificity and predictive positive and negative values were calculated to measure agreement between all the human observers and in comparison with the automated DDA. Our results revealed poor reproducibility of the semi-quantitative algorithm devised by Stolz et al. independently of observers' experience in dermoscopy. Nevuscreen(®) (Arkè s.a.s., Avezzano, Italy) proved to be 'user friendly' to all observers, thus enabling a more critical evaluation of each lesion and representing a helpful tool for clinicians without significant experience in dermoscopy in improving and achieving more accurate diagnosis of PSLs.

The addition of E (Empowerment and Economics) to the ABCD algorithm in diabetes care.

PubMed

Khazrai, Yeganeh Manon; Buzzetti, Raffaella; Del Prato, Stefano; Cahn, Avivit; Raz, Itamar; Pozzilli, Paolo

2015-01-01

The ABCD (Age, Body weight, Complications, Duration of disease) algorithm was proposed as a simple and practical tool to manage patients with type 2 diabetes. Diabetes treatment, as for all chronic diseases, relies on patients' ability to cope with daily problems concerning the management of their disease in accordance with medical recommendations. Thus, it is important that patients learn to manage and cope with their disease and gain greater control over actions and decisions affecting their health. Healthcare professionals should aim to encourage and increase patients' perception about their ability to take informed decisions about disease management and to improve patient self-esteem and feeling of self-efficacy to become agents of their own health. E for Empowerment is therefore an additional factor to take into account in the management of patients with type 2 diabetes. E stands also for Economics to be considered in diabetes care. Attention should be paid to public health policies as well as to the physician faced with the dilemma of delivering the best possible care within the problem of limited resources. The financial impact of the new treatment modalities for diabetes represents an issue that needs to be addressed at multiple strata both globally and nationally. Copyright © 2015 Elsevier Inc. All rights reserved.

Frailty and geography: should these two factors be added to the ABCDE contemporary guide to diabetes therapy?

PubMed

Maddaloni, Ernesto; D'Onofrio, Luca; Pozzilli, Paolo

2016-02-01

On the road towards personalized treatments for type 2 diabetes, we suggest here that two parameters could be added to the ABCDE algorithm, 'F' for frailty and 'G' for geography. Indeed, the progressive ageing of population is causing a simultaneous increase of frailty worldwide. The identification of the optimal therapeutic approach is often difficult in frail subjects because of the complexity of 'frailty syndrome'. Nevertheless, given the relevance of diabetes in the development and progression of frailty, a safe and effective cure of diabetes is extremely important to guarantee a good medical outcome. There are few data about diabetes treatment in this delicate category of patients, and the choice of the appropriate therapy mostly remains a challenge. Moreover, type 2 diabetes affects more than 382 million people of different countries, races and ethnicities. To face the lack of solid evidence-based medicine for the treatment of diabetes in different ethnic groups, it is extremely important to increase knowledge about the different pathophysiology of diabetes according to ethnicity. In this way, a tailored approach to treatment of various ethnic groups living in the same or different regions can eventually be developed. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

Excitonic energy transfer in light-harvesting complexes in purple bacteria

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ye Jun; Sun Kewei; Zhao Yang

Two distinct approaches, the Frenkel-Dirac time-dependent variation and the Haken-Strobl model, are adopted to study energy transfer dynamics in single-ring and double-ring light-harvesting (LH) systems in purple bacteria. It is found that the inclusion of long-range dipolar interactions in the two methods results in significant increase in intra- or inter-ring exciton transfer efficiency. The dependence of exciton transfer efficiency on trapping positions on single rings of LH2 (B850) and LH1 is similar to that in toy models with nearest-neighbor coupling only. However, owing to the symmetry breaking caused by the dimerization of BChls and dipolar couplings, such dependence has beenmore » largely suppressed. In the studies of coupled-ring systems, both methods reveal an interesting role of dipolar interactions in increasing energy transfer efficiency by introducing multiple intra/inter-ring transfer paths. Importantly, the time scale (4 ps) of inter-ring exciton transfer obtained from polaron dynamics is in good agreement with previous studies. In a double-ring LH2 system, non-nearest neighbor interactions can induce symmetry breaking, which leads to global and local minima of the average trapping time in the presence of a non-zero dephasing rate, suggesting that environment dephasing helps preserve quantum coherent energy transfer when the perfect circular symmetry in the hypothetic system is broken. This study reveals that dipolar coupling between chromophores may play an important role in the high energy transfer efficiency in the LH systems of purple bacteria and many other natural photosynthetic systems.« less

Large transient fault current test of an electrical roll ring

NASA Technical Reports Server (NTRS)

Yenni, Edward J.; Birchenough, Arthur G.

1992-01-01

The space station uses precision rotary gimbals to provide for sun tracking of its photoelectric arrays. Electrical power, command signals and data are transferred across the gimbals by roll rings. Roll rings have been shown to be capable of highly efficient electrical transmission and long life, through tests conducted at the NASA Lewis Research Center and Honeywell's Satellite and Space Systems Division in Phoenix, AZ. Large potential fault currents inherent to the power system's DC distribution architecture, have brought about the need to evaluate the effects of large transient fault currents on roll rings. A test recently conducted at Lewis subjected a roll ring to a simulated worst case space station electrical fault. The system model used to obtain the fault profile is described, along with details of the reduced order circuit that was used to simulate the fault. Test results comparing roll ring performance before and after the fault are also presented.

The Age of Saturn's Rings Constrained by the Meteoroid Flux Into the System

NASA Astrophysics Data System (ADS)

Kempf, S.; Altobelli, N.; Srama, R.; Cuzzi, J. N.; Estrada, P. R.

2017-12-01

The origin of Saturn's ring is still not known. There is an ongoing argument whether Saturn's ring are rather young or have been formed shortly after Saturn together with its satellites. The water-ice rings contain about 5% rocky material resulting from continuous meteoroid bombardment of the ring material with interplanetary micrometeoroids. Knowledge of the incoming mass flux would allow to estimate the ring's exposure time. Model calculations suggest exposure times of 108 years implying a late ring formation. This scenario is problematic because the tidal disruption of a Mimas-sized moon or of a comet within the planet's Roche zone would lead to a much larger rock content as observed today. Here we report on the measurement of the meteoroid mass flux into the Saturnian system obtained by the charge-sensitive entrance grid system (QP) of the Cosmic Dust Analyser (CDA) on the Cassini spacecraft. Interplanetary dust particles (IDPs) entering Saturn's sphere of gravitational influence are identified through the measurements of their speed vectors. We analyzed the full CDA data set acquired after Cassini's arrival at Saturn in 2004, identified the impact speed vectors of 128 extrinsic micrometeoroids ≥ 2 μm, and determined their orbital elements. On the basis of these measurements we determined the mass flux into the Saturnian system. Our preliminary findings are in support of an old ring. The knowledge of the meteoroids orbital elements allows us for the first time to characterize the meteoroid environment in the outer solar system based on direct measurements.

Systematic Search for Rings around Kepler Planet Candidates: Constraints on Ring Size and Occurrence Rate

NASA Astrophysics Data System (ADS)

Aizawa, Masataka; Masuda, Kento; Kawahara, Hajime; Suto, Yasushi

2018-05-01

We perform a systematic search for rings around 168 Kepler planet candidates with sufficient signal-to-noise ratios that are selected from all of the short-cadence data. We fit ringed and ringless models to their light curves and compare the fitting results to search for the signatures of planetary rings. First, we identify 29 tentative systems, for which the ringed models exhibit statistically significant improvement over the ringless models. The light curves of those systems are individually examined, but we are not able to identify any candidate that indicates evidence for rings. In turn, we find several mechanisms of false positives that would produce ringlike signals, and the null detection enables us to place upper limits on the size of the rings. Furthermore, assuming the tidal alignment between axes of the planetary rings and orbits, we conclude that the occurrence rate of rings larger than twice the planetary radius is less than 15%. Even though the majority of our targets are short-period planets, our null detection provides statistical and quantitative constraints on largely uncertain theoretical models of the origin, formation, and evolution of planetary rings.

A novel cell model to study the function of the adrenoleukodystrophy-related protein

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gueugnon, Fabien; Volodina, Natalia; Taouil, Jaoued Et

2006-03-03

X-linked adrenoleukodystrophy (X-ALD) is a neurodegenerative disorder due to mutations in the ABCD1 (ALD) gene. ALDRP, the closest homolog of ALDP, has been shown to have partial functional redundancy with ALDP and, when overexpressed, can compensate for the loss-of-function of ALDP. In order to characterize the function of ALDRP and to understand the phenomenon of gene redundancy, we have developed a novel system that allows the controlled expression of the ALDRP-EGFP fusion protein (normal or non-functional mutated ALDRP) using the Tet-On system in H4IIEC3 rat hepatoma cells. The generated stable cell lines express negligible levels of endogenous ALDRP and doxycyclinemore » dosage-dependent levels of normal or mutated ALDRP. Importantly, the ALDRP-EGFP protein is targeted correctly to peroxisome and is functional. The obtained cell lines will be an indispensable tool in our further studies aimed at the resolution of the function of ALDRP to characterize its potential substrates in a natural context.« less

No evidence of rings around Neptune

NASA Technical Reports Server (NTRS)

Elliot, J. L.; Mink, D. J.; Baron, R. L.; Dunham, E.; Pingree, J. E.; French, R. G.; Elias, J. H.; Liller, W.; Nicholson, P. D.; Jones, T. J.

1981-01-01

The results of two observations of stellar occultations of Neptune to determine if the planet has a ring system are reported. The sightings were made from Mt. Stromlo, Mauna Kea, and Cerro Tololo, noting that an equatorial ring would subtend only two arcsec of view. An upper accretion limit was defined to set the region around Neptune where rings, rather than satellites, could form. The intensities of the starlight from the two selected stars were recorded by photometers on magnetic tape during the occultation period. One of the stars did not occult, but passed through the entire region where a ring system might be present. No definitive evidence for rings was found, although an optical depth for a Neptunian ring was calculated at 0.07, with a width of more than 5 km and a radius of 31,400 km.

Saturn's largest ring.

PubMed

Verbiscer, Anne J; Skrutskie, Michael F; Hamilton, Douglas P

2009-10-22

Most planetary rings in the Solar System lie within a few radii of their host body, because at these distances gravitational accelerations inhibit satellite formation. The best known exceptions are Jupiter's gossamer rings and Saturn's E ring, broad sheets of dust that extend outward until they fade from view at five to ten planetary radii. Source satellites continuously supply the dust, which is subsequently lost in collisions or by radial transport. Here we report that Saturn has an enormous ring associated with its outer moon Phoebe, extending from at least 128R(S) to 207R(S) (Saturn's radius R(S) is 60,330 km). The ring's vertical thickness of 40R(S) matches the range of vertical motion of Phoebe along its orbit. Dynamical considerations argue that these ring particles span the Saturnian system from the main rings to the edges of interplanetary space. The ring's normal optical depth of approximately 2 x 10(-8) is comparable to that of Jupiter's faintest gossamer ring, although its particle number density is several hundred times smaller. Repeated impacts on Phoebe, from both interplanetary and circumplanetary particle populations, probably keep the ring populated with material. Ring particles smaller than centimetres in size slowly migrate inward and many of them ultimately strike the dark leading face of Iapetus.

Jupiter Ring Halo

NASA Image and Video Library

1998-03-26

A mosaic of four images taken through the clear filter (610 nanometers) of the solid state imaging (CCD) system aboard NASA's Galileo spacecraft on November 8, 1996, at a resolution of approximately 46 kilometers (km) per picture element (pixel) along the rings; however, because the spacecraft was only about 0.5 degrees above the ring plane, the image is highly foreshortened in the vertical direction. The images were obtained when Galileo was in Jupiter's shadow peering back toward the Sun; the ring was approximately 2,300,000 kilometers (km) away. The arc on the far right of the image is produced by sunlight scattered by small particles comprising Jupiter's upper atmospheric haze. The ring also efficiently scatters light, indicating that much of its brightness is due to particles that are microns or less in diameter. Such small particles are believed to have human-scale lifetimes, i.e., very brief compared to the solar system's age. Jupiter's ring system is composed of three parts -- a flat main ring, a lenticular halo interior to the main ring, and the gossamer ring, which lies exterior to the main ring. The near and far arms of Jupiter's main ring extend horizontally across the mosaic, joining together at the ring's ansa, on the far left side of the figure. The near arm of the ring appears to be abruptly truncated close to the planet, at the point where it passes into Jupiter's shadow. A faint mist of particles can be seen above and below the main rings; this vertically extended, toroidal "halo" is unusual in planetary rings, and is probably caused by electromagnetic forces which can push small grains out of the ring plane. Halo material is present across this entire image, implying that it reaches more than 27,000 km above the ring plane. Because of shadowing, the halo is not visible close to Jupiter in the lower right part of the mosaic. In order to accentuate faint features in the image, different brightnesses are shown through color, with the brightest being white or yellow and the faintest purple. http://photojournal.jpl.nasa.gov/catalog/PIA00658

Ring-laser gyroscope system using dispersive element(s)

NASA Technical Reports Server (NTRS)

Smith, David D. (Inventor)

2010-01-01

A ring-laser gyroscope system includes a ring-laser gyroscope (RLG) and at least one dispersive element optically coupled to the RLG's ring-shaped optical path. Each dispersive element has a resonant frequency that is approximately equal to the RLG's lasing frequency. A group index of refraction defined collectively by the dispersive element(s) has (i) a real portion that is greater than zero and less than one, and (ii) an imaginary portion that is less than zero.

The Abort Kicker System for the PEP-II Storage Rings at SLAC.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Delamare, Jeffrey E

2003-06-20

The PEP-II project has two storage rings. The HER (High Energy Ring) has up to 1.48 A of election beam at 9 GeV, and the LER (Low Energy Ring) has up to 2.14 A of positron beam at 3.1 GeV. To protect the HER and LER beam lines in the event of a ring component failure, each ring has an abort kicker system which directs the beam into a dump when a failure is detected. Due to the high current of the beams, the beam kick is tapered from 100% to 80% in 7.33 {micro}S (the beam transit time aroundmore » the ring). This taper distributes the energy evenly across the window which separates the ring from the beam dump such that the window is not damaged. The abort kicker trigger is synchronized with the ion clearing gap of the beam allowing for the kicker field to rise from 0-80% while there is no beam in the kicker magnet. Originally the kicker system was designed for a rise time of 370nS [1], but because the ion clearing gap was reduced in half, so was the rise time requirement for the kicker. This report discusses the design of the system interlocks, diagnostics, and modulator with the modifications necessary to accommodate an ion clearing gap of 185nS.« less

Configuration maintaining control of three-body ring tethered system based on thrust compensation

NASA Astrophysics Data System (ADS)

Huang, Panfeng; Liu, Binbin; Zhang, Fan

2016-06-01

Space multi-tethered systems have shown broad prospects in remote observation missions. This paper mainly focuses on the dynamics and configuration maintaining control of space spinning three-body ring tethered system for such mission. Firstly, we establish the spinning dynamic model of the three-body ring tethered system considering the elasticity of the tether using Newton-Euler method, and then validate the suitability of this model by numerical simulation. Subsequently, LP (Likins-Pringle) initial equilibrium conditions for the tethered system are derived based on rigid body's equilibrium theory. Simulation results show that tether slack, snapping and interaction between the tethers exist in the three-body ring system, and its' configuration can not be maintained without control. Finally, a control strategy based on thrust compensation, namely thrust to simulate tether compression under LP initial equilibrium conditions is designed to solve the configuration maintaining control problem. Control effects are verified by numerical simulation compared with uncontrolled situation. Simulation results show that the configuration of the three-body ring tethered system could maintain under this active control strategy.

A measuring tool for tree-rings analysis

NASA Astrophysics Data System (ADS)

Shumilov, Oleg; Kanatjev, Alexander; Kasatkina, Elena

2013-04-01

A special tool has been created for the annual tree-ring widths measurement and analysis. It consists of professional scanner, computer system and software. This created complex in many aspects does not yield the similar systems (LINTAB, WinDENDRO), but in comparison to manual measurement systems, it offers a number of advantages: productivity gain, possibility of archiving the results of the measurements at any stage of the processing, operator comfort. It has been developed a new software, allowing processing of samples of different types (cores, saw cuts), including those which is difficult to process, having got a complex wood structure (inhomogeneity of growing in different directions, missed, light and false rings etc.). This software can analyze pictures made with optical scanners, analog or digital cameras. The complex software program was created on programming language C++, being compatible with modern operating systems like Windows X. Annual ring widths are measured along paths traced interactively. These paths can have any orientation and can be created so that ring widths are measured perpendicular to ring boundaries. A graphic of ring-widths in function of the year is displayed on a screen during the analysis and it can be used for visual and numerical cross-dating and comparison with other series or master-chronologies. Ring widths are saved to the text files in a special format, and those files are converted to the format accepted for data conservation in the International Tree-Ring Data Bank. The created complex is universal in application that will allow its use for decision of the different problems in biology and ecology. With help of this complex it has been reconstructed a long-term juniper (1328-2004) and pine (1445-2005) tree-ring chronologies on the base of samples collected at Kola Peninsula (northwestern Russia).

Transfer matrix approach to the persistent current in quantum rings: Application to hybrid normal-superconducting rings

NASA Astrophysics Data System (ADS)

Nava, Andrea; Giuliano, Rosa; Campagnano, Gabriele; Giuliano, Domenico

2016-11-01

Using the properties of the transfer matrix of one-dimensional quantum mechanical systems, we derive an exact formula for the persistent current across a quantum mechanical ring pierced by a magnetic flux Φ as a single integral of a known function of the system's parameters. Our approach provides exact results at zero temperature, which can be readily extended to a finite temperature T . We apply our technique to exactly compute the persistent current through p -wave and s -wave superconducting-normal hybrid rings, deriving full plots of the current as a function of the applied flux at various system's scales. Doing so, we recover at once a number of effects such as the crossover in the current periodicity on increasing the size of the ring and the signature of the topological phase transition in the p -wave case. In the limit of a large ring size, resorting to a systematic expansion in inverse powers of the ring length, we derive exact analytic closed-form formulas, applicable to a number of cases of physical interest.

Collisional and dynamical processes in moon and planet formation

NASA Technical Reports Server (NTRS)

Chapman, C. R.; Davis, D. R.; Weidenschilling, S. J.; Hartmann, W. K.; Spaute, D.

1987-01-01

Research on a variety of dynamical processes relevant to the formation of planets, satellites and ring systems is discussed. The main focus is on studies of accretionary formation of early protoplanets using a numerical model, structures and evolution of ring systems and individual bodies within planetary rings, and theories of lunar origin.

Warden’s Five-Ring System Theory: Legitimate Wartime Military Targeting or an Increased Potential to Violate the Law and Norms of Expected Behavior?

DTIC Science & Technology

2000-04-01

the five-ring system theory that dramatically improves the warfighters ability to systematically identify wartime targets. However, for all of its...acclaim, little has been written about Warden’s five-ring system theory . Even less has been written about the legal and moral implications of using Warden’s theory to identify wartime targets.

A pulsed jumping ring apparatus for demonstration of Lenz's law

NASA Astrophysics Data System (ADS)

Tanner, Paul; Loebach, Jeff; Cook, James; Hallen, H. D.

2001-08-01

Lenz's law is often demonstrated in classrooms by the use of Elihu Thomson's jumping ring. However, it is ironic that a thorough analysis of the physics of the ac jumping ring reveals that the operation is due mainly to a phase difference, not Lenz's law. A complete analysis of the physics behind the ac jumping ring is difficult for the introductory student. We present a design for a pulsed jumping ring which can be fully described by the application of Lenz's law. Other advantages of this system are that it lends itself to a rigorous analysis of the force balances and energy flow. The simple jumping ring apparatus closely resembles Thomson's, but is powered by a capacitor bank. The jump heights were measured for several rings as a function of energy stored in the capacitors. A simple model describes the data well. Currents in both the drive coil and ring are measured and that of the drive coil modeled to illuminate some properties of the capacitors. An analysis of the energy flow in the system explains the higher jump heights, to 2 m, when the ring is cooled.

Passive Vibration Control of Airborne Equipment using a Circular Steel Ring

NASA Technical Reports Server (NTRS)

Ellison, Joseph; Ahmadi, Goodarz; Kehoe, Mike

1997-01-01

Vibration isolation is needed to protect avionics equipment from adverse aircraft vibration environments. Passive isolation is the simplest means to achieve this goal. The system used here consists of a circular steel ring with a lump mass on top and exposed to base excitation. Sinusoidal and filtered zero-mean Gaussian white noise are used to excite the structure and the acceleration response spectra at the top of the ring are computed. An experiment is performed to identify the natural frequencies and modal damping of the circular ring. Comparison is made between the analytical and experimental results and good agreement is observed. The ring response is also evaluated with a concentrated mass attached to the top of the ring. The effectiveness of the ring in isolating the equipment from base excitation is studied. The acceleration response spectra of a single degree of freedom system attached to the top of the ring are evaluated and the results are compared with those exposed directly to the base excitation. It is shown that a properly designed ring could effectively protect the avionics from possible damaging excitation levels.

Compositional Evolution of Saturn's Rings Due to Meteoroid Bombardment

NASA Technical Reports Server (NTRS)

Cuzzi, J.; Estrada, P.; Young, Richard E. (Technical Monitor)

1997-01-01

In this paper we address the question of compositional evolution in planetary ring systems subsequent to meteoroid bombardment. The huge surface area to mass ratio of planetary rings ensures that this is an important process, even with current uncertainties on the meteoroid flux. We develop a new model which includes both direct deposition of extrinsic meteoritic "pollutants", and ballistic transport of the increasingly polluted ring material as impact ejecta. Our study includes detailed radiative transfer modeling of ring particle spectral reflectivities based on refractive indices of realistic constituents. Voyager data have shown that the lower optical depth regions in Saturn's rings (the C ring and Cassini Division) have darker and less red particles than the optically thicken A and B rings. These coupled structural-compositional groupings have never been explained; we present and explore the hypothesis that global scale color and compositional differences in the main rings of Saturn arise naturally from extrinsic meteoroid bombardment of a ring system which was initially composed primarily, but not entirely, of water ice. We find that the regional color and albedo differences can be understood if all ring material was initially identical (primarily water ice, based on other data, but colored by tiny amounts of intrinsic reddish, plausibly organic, absorber) and then evolved entirely by addition and mixing of extrinsic, nearly neutrally colored. plausibly carbonaceous material. We further demonstrate that the detailed radial profile of color across the abrupt B ring - C ring boundary can.constrain key unknown parameters in the model. Using new alternates of parameter values, we estimate the duration of the exposure to extrinsic meteoroid flux of this part of the rings, at least, to be on the order of 10(exp 8) years. This conclusion is easily extended by inference to the Cassini Division and its surroundings as well. This geologically young "age" is compatible with timescales estimated elsewhere based on the evolution of ring structure due to ballistic transport, and also with other "short timescales" estimated on the grounds of gravitational torques. However, uncertainty in the flux of interplanetary debris and in the ejects yield may preclude ruling out a ring age as old as the solar system at this time.

Differential Calculus on h-Deformed Spaces

NASA Astrophysics Data System (ADS)

Herlemont, Basile; Ogievetsky, Oleg

2017-10-01

We construct the rings of generalized differential operators on the h-deformed vector space of gl-type. In contrast to the q-deformed vector space, where the ring of differential operators is unique up to an isomorphism, the general ring of h-deformed differential operators {Diff}_{h},σ(n) is labeled by a rational function σ in n variables, satisfying an over-determined system of finite-difference equations. We obtain the general solution of the system and describe some properties of the rings {Diff}_{h},σ(n).

Characterizing exo-ring systems around fast-rotating stars using the Rossiter-McLaughlin effect

NASA Astrophysics Data System (ADS)

de Mooij, Ernst J. W.; Watson, Christopher A.; Kenworthy, Matthew A.

2017-12-01

Planetary rings produce a distinct shape distortion in transit light curves. However, to accurately model such light curves the observations need to cover the entire transit, especially ingress and egress, as well as an out-of-transit baseline. Such observations can be challenging for long period planets, where the transits may last for over a day. Planetary rings will also impact the shape of absorption lines in the stellar spectrum, as the planet and rings cover different parts of the rotating star (the Rossiter-McLaughlin effect). These line-profile distortions depend on the size, structure, opacity, obliquity and sky-projected angle of the ring system. For slow-rotating stars, this mainly impacts the amplitude of the induced velocity shift; however, for fast-rotating stars the large velocity gradient across the star allows the line distortion to be resolved, enabling direct determination of the ring parameters. We demonstrate that by modelling these distortions we can recover ring system parameters (sky-projected angle, obliquity and size) using only a small part of the transit. Substructure in the rings, e.g. gaps, can be recovered if the width of the features (δW) relative to the size of the star is similar to the intrinsic velocity resolution (set by the width of the local stellar profile, γ) relative to the stellar rotation velocity (v sini, i.e. δW/R* ≳ vsini/γ). This opens up a new way to study the ring systems around planets with long orbital periods, where observations of the full transit, covering the ingress and egress, are not always feasible.

Simulating the Smallest Ring World of Chariklo

NASA Astrophysics Data System (ADS)

Michikoshi, Shugo; Kokubo, Eiichiro

2017-03-01

A ring system consisting of two dense narrow rings has been discovered around Centaur Chariklo. The existence of these rings around a small object poses various questions about their origin, stability, and lifetime. In order to understand the nature of Chariklo’s rings, we perform global N-body simulations of the self-gravitating collisional particle rings for the first time. We find that Chariklo should be denser than the ring material in order to avoid the rapid diffusion of the rings. If Chariklo is denser than the ring material, fine spiral structures called self-gravity wakes occur in the inner ring. These wakes accelerate the viscous spreading of the ring significantly and typically occur on timescales of about 100 {years} for m-sized ring particles, which is considerably shorter than the timescales suggested in previous studies. The existence of these narrow rings implies smaller ring particles or the existence of shepherding satellites.

Multiple internal seal ring micro-electro-mechanical system vacuum packaging method

NASA Technical Reports Server (NTRS)

Hayworth, Ken J. (Inventor); Yee, Karl Y. (Inventor); Shcheglov, Kirill V. (Inventor); Bae, Youngsam (Inventor); Wiberg, Dean V. (Inventor); Challoner, A. Dorian (Inventor); Peay, Chris S. (Inventor)

2008-01-01

A Multiple Internal Seal Ring (MISR) Micro-Electro-Mechanical System (MEMS) vacuum packaging method that hermetically seals MEMS devices using MISR. The method bonds a capping plate having metal seal rings to a base plate having metal seal rings by wafer bonding the capping plate wafer to the base plate wafer. Bulk electrodes may be used to provide conductive paths between the seal rings on the base plate and the capping plate. All seals are made using only metal-to-metal seal rings deposited on the polished surfaces of the base plate and capping plate wafers. However, multiple electrical feed-through metal traces are provided by fabricating via holes through the capping plate for electrical connection from the outside of the package through the via-holes to the inside of the package. Each metal seal ring serves the dual purposes of hermetic sealing and providing the electrical feed-through metal trace.

Saturn Rings Origin: Quantum Trapping of Superconducting Iced Particles and Meissner Effect Lead to the Stable Rings System

NASA Astrophysics Data System (ADS)

Viktorovich Tchernyi, Vladimir

2018-06-01

Saturn Rings Origin: Quantum Trapping of Superconducting Iced Particles and Meissner Effect Lead to the Stable Rings System Vladimir V. Tchernyi (Cherny), Andrew Yu. Pospelov Modern Science Institute, SAIBR, Moscow, Russia. E-mail: chernyv@bk.ruAbstractIt is demonstrated how superconducting iced particles of the protoplanetary cloud of Saturn are coming to magnetic equator plane and create the stable enough rings disk. There are two steps. First, after appearance of the Saturn magnetic field due to Meissner phenomenon all particles orbits are moving to the magnetic equator plane. Finally they become distributed as rings and gaps like iron particles around magnet on laboratory table. And they are separated from each other by the magnetic field expelled from them. It takes up to few tens of thousands years with ten meters rings disk thickness. Second, due to their quantum trapping all particles become to be trapped within magnetic well at the magnetic equator plane due to Abrikosov vortex for superconductor. It works even when particles have small fraction of superconductor. During the rings evolution some contribution to the disk also could come from the collision-generated debris of the current moon and from the geysers like it happened due to magnetic coupling of Saturn and Enceladus. The rings are relict of the early days of the magnetic field of Saturn system.

Comparison of the DeWitt metric in general relativity with the fourth-rank constitutive tensors in electrodynamics and in elasticity theory

NASA Astrophysics Data System (ADS)

Hehl, Friedrich W.; Kiefer, Claus

2018-01-01

We perform a short comparison between the local and linear constitutive tensor χ ^{λ ν σ κ } in four-dimensional electrodynamics, the elasticity tensor c^{ijkl} in three-dimensional elasticity theory, and the DeWitt metric G^{abcd} in general relativity, with {a,b,\\ldots =1,2,3}. We find that the DeWitt metric has only six independent components.

Uncovering a new Uranus ring-moon connection in 25 years of occultation data

NASA Astrophysics Data System (ADS)

Chancia, R. O.; Hedman, M. M.; French, R. G.

2017-12-01

The Uranus ring-moon system consists of 10 narrow and dense main rings, 3 broad diffuse and dusty rings, and 13 small inner moons. Nine of these moons, dubbed the `Portia group', orbit within a radial range of less than 20,000 km, making them the most tightly packed system of moons in our solar system. For the first time, we have constrained the mass of one of the inner moons by measuring its gravitational influence on the η ring. The η ring is one of the narrow rings of Uranus, consisting of a dense core that is 1-2 km wide and a diffuse outer sheet spanning about 40 km. Its dense core lies just exterior to the 3:2 Inner Lindblad Resonance of the small moon Cressida. We fit the η ring radius residuals and longitudes from a complete set of both ground-based and Voyager stellar and radio occultations of the Uranian rings spanning 1977-2002. We find variations in the radial position of the η ring that are likely generated by this resonance, and take the form of a 3-lobed structure rotating at an angular rate equal to the mean motion of the moon Cressida. The amplitude of these radial oscillations is 0.667 ± 0.113 km, which is consistent with the expected shape due to the perturbations of Cressida. The magnitude of these variations provides the first measurement of the mass and density of the moon Cressida or, indeed, any of Uranus' small inner moons. The system has previously been simulated over a wide range of presumed masses and is found to be dynamically unstable, with the next collision most likely occurring in less than a few million years. Two of the broad dusty rings orbit in range of the moons and may be evidence of collisions in the recent past. A better grasp of inner Uranian satellite masses will provide another clue to the composition, dynamical stability, and history of this tightly packed system of moons.

Electro-optical hybrid slip ring

NASA Astrophysics Data System (ADS)

Hong, En

2005-11-01

The slip ring is a rotary electrical interface, collector, swivel or rotary joint. It is a physical system that can perform continuous data transfer and data exchange between a stationary and a rotating structure. A slip ring is generally used to transfer data or power from an unrestrained, continuously rotating electro-mechanical system in real-time, thereby simplifying operations and eliminating damage-prone wires dangling from moving joints. Slip rings are widely used for testing, evaluating, developing and improving various technical equipment and facilities with rotating parts. They are widely used in industry, especially in manufacturing industries employing turbo machinery, as in aviation, shipbuilding, aerospace, defense, and in precise facilities having rotating parts such as medical Computerized Tomography (CT) and MRI scanners and so forth. Therefore, any improvement in slip ring technology can impact large markets. Research and development in this field will have broad prospects long into the future. The goal in developing the current slip ring technology is to improve and increase the reliability, stability, anti-interference, and high data fidelity between rotating and stationary structures. Up to now, there have been numerous approaches used for signal and data transfer utilizing a slip ring such as metal contacts, wires, radio transmission, and even liquid media. However, all suffer from drawbacks such as data transfer speed limitations, reliability, stability, electro-magnetic interference and durability. The purpose of the current research is to break through these basic limitations using an optical solution, thereby improving performance in current slip ring applications. This dissertation introduces a novel Electro-Optical Hybrid Slip Ring technology, which makes "through the air" digital-optical communication between stationary and rotating systems a reality with high data transfer speed, better reliability and low interference susceptibility. A laboratory scale non-contact Electro-Optical Hybrid Slip Ring system was successfully constructed, and its performance was determined. Experimental results affirmed the advantages of this new technology over current slip ring design.

Alstom Francis Turbine Ring Gates: from Retrofitting to Commissioning

NASA Astrophysics Data System (ADS)

A, Nguyen P.; G, Labrecque; M-O, Thibault; M, Bergeron; A, Steinhilber; D, Havard

2014-03-01

The Ring Gate synchronisation system developed by Alstom is new and patented. It uses hydraulic cylinders connected in pairs by a serial connection. The new hydraulic synchronisation system, when compared to the previous mechanical synchronisation system, has several advantages. It is a compact design; it reduces the number of mechanical components as well as maintenance costs. The new system maintains the Ring Gates robustness. The new approach is an evolution from mechanical to hydraulic synchronization assisted by electronic control. The new synchronization system eliminates several mechanical components that used to add wear and friction and which are usually difficult to adjust during maintenance. Tension chains and sprockets and associated controls are eliminated. Through the position sensors, the redundancy of the ring gate synchronization system makes it predictable and reliable. The electronic control compensates for any variation in operation, for example a leak in the hydraulic system. An emergency closing is possible without the electronic control system due to the stiffness of hydraulic serial connection in the hydraulic cylinder pairs. The Ring Gate can work safely against uneven loads and frictions. The development will be reviewed and its application discussed through commissioning results.

Single-pass BPM system of the Photon Factory storage ring.

PubMed

Honda, T; Katoh, M; Mitsuhashi, T; Ueda, A; Tadano, M; Kobayashi, Y

1998-05-01

At the 2.5 GeV ring of the Photon Factory, a single-pass beam-position monitor (BPM) system is being prepared for the storage ring and the beam transport line. In the storage ring, the injected beam position during the first several turns can be measured with a single injection pulse. The BPM system has an adequate performance, useful for the commissioning of the new low-emittance lattice. Several stripline BPMs are being installed in the beam transport line. The continuous monitoring of the orbit in the beam transport line will be useful for the stabilization of the injection energy as well as the injection beam orbit.

Real-time track-less Cherenkov ring fitting trigger system based on Graphics Processing Units

NASA Astrophysics Data System (ADS)

Ammendola, R.; Biagioni, A.; Chiozzi, S.; Cretaro, P.; Cotta Ramusino, A.; Di Lorenzo, S.; Fantechi, R.; Fiorini, M.; Frezza, O.; Gianoli, A.; Lamanna, G.; Lo Cicero, F.; Lonardo, A.; Martinelli, M.; Neri, I.; Paolucci, P. S.; Pastorelli, E.; Piandani, R.; Piccini, M.; Pontisso, L.; Rossetti, D.; Simula, F.; Sozzi, M.; Vicini, P.

2017-12-01

The parallel computing power of commercial Graphics Processing Units (GPUs) is exploited to perform real-time ring fitting at the lowest trigger level using information coming from the Ring Imaging Cherenkov (RICH) detector of the NA62 experiment at CERN. To this purpose, direct GPU communication with a custom FPGA-based board has been used to reduce the data transmission latency. The GPU-based trigger system is currently integrated in the experimental setup of the RICH detector of the NA62 experiment, in order to reconstruct ring-shaped hit patterns. The ring-fitting algorithm running on GPU is fed with raw RICH data only, with no information coming from other detectors, and is able to provide more complex trigger primitives with respect to the simple photodetector hit multiplicity, resulting in a higher selection efficiency. The performance of the system for multi-ring Cherenkov online reconstruction obtained during the NA62 physics run is presented.

Cavity-locked ring down spectroscopy

DOEpatents

Zare, Richard N.; Paldus, Barbara A.; Harb, Charles C.; Spence, Thomas

2000-01-01

Distinct locking and sampling light beams are used in a cavity ring-down spectroscopy (CRDS) system to perform multiple ring-down measurements while the laser and ring-down cavity are continuously locked. The sampling and locking light beams have different frequencies, to ensure that the sampling and locking light are decoupled within the cavity. Preferably, the ring-down cavity is ring-shaped, the sampling light is s-polarized, and the locking light is p-polarized. Transmitted sampling light is used for ring-down measurements, while reflected locking light is used for locking in a Pound-Drever scheme.

National Synchrotron Light Source II storage ring vacuum systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hseuh, Hsiao-Chaun, E-mail: hseuh@bnl.gov; Hetzel, Charles; Leng, Shuwei

2016-05-15

The National Synchrotron Light Source II, completed in 2014, is a 3-GeV synchrotron radiation (SR) facility at Brookhaven National Laboratory and has been in steady operation since. With a design electron current of 500 mA and subnanometer radians horizontal emittance, this 792-m circumference storage ring is providing the highest flux and brightness x-ray beam for SR users. The majority of the storage ring vacuum chambers are made of extruded aluminium. Chamber sections are interconnected using low-impedance radiofrequency shielded bellows. SR from the bending magnets is intercepted by water-cooled compact photon absorbers resided in the storage ring chambers. This paper presents themore » design of the storage ring vacuum system, the fabrication of vacuum chambers and other hardware, the installation, the commissioning, and the continuing beam conditioning of the vacuum systems.« less

The LEO Archipelago: A system of earth-rings for communications, mass-transport to space, solar power, and control of global warming

NASA Astrophysics Data System (ADS)

Meulenberg, Andrew; Karthik Balaji, P. S.

2011-06-01

Man's quest to get into space is hindered by major problems (e.g., system-development and capital costs, expense of putting mass into orbit, trapped-radiation belts, and environmental impact of a large increase in rocket launches). A multi-purpose low-earth-orbit system of rings circling the earth - the "LEO ARCHIPELAGO TM" - is proposed as a means of solving or bypassing many of them. A fiber-optic ring about the earth would be an initial testing and developmental stage for the Ring Systems, while providing cash-flow through a LEO-based, high-band-width, world-wide communication system. A low-earth-orbit-based space-elevator system, "Sling-on-a-Ring TM", is proposed as the crucial developmental stage of the LEO Archipelago. Being a LEO-based heavy-mass lifter, rather than earth- or GEO-based, it is much less massive and therefore less costly than other proposed space-elevators. With the advent of lower-cost, higher-mass transport to orbit, the options for further space development (e.g., space solar power, radiation, and space-debris dampers, sun shades, and permanent LEO habitation) are greatly expanded. This paper provides an update of the Sling-on-a-Ring concept in terms of new materials, potential applications, and trade-offs associated with an earlier model. The impact of Colossal Carbon Tubes, CCT, a new material with high tensile strength, extremely-low density, and other favorable properties, and other new technologies (e.g., solar-powered lasers, power beaming to near-space and earth, and thermal-control systems) on the development of associated LEO-Ring systems is also explored. The material's effect on the timeline for the system development indicates the feasibility of near-term implementation of the system (possibly within the decade). The Sling-on-a-Ring can provide a less-expensive, environment-friendly mode of access to space. This would pave the way (via eventual operation at >1000 t per day by 2050) for large scale development of space-based technologies.

The New Horizons and Hubble Space Telescope search for rings, dust, and debris in the Pluto-Charon system

NASA Astrophysics Data System (ADS)

Lauer, Tod R.; Throop, Henry B.; Showalter, Mark R.; Weaver, Harold A.; Stern, S. Alan; Spencer, John R.; Buie, Marc W.; Hamilton, Douglas P.; Porter, Simon B.; Verbiscer, Anne J.; Young, Leslie A.; Olkin, Cathy B.; Ennico, Kimberly; New Horizons Science Team

2018-02-01

We conducted an extensive search for dust or debris rings in the Pluto-Charon system before, during, and after the New Horizons encounter in July 2015. Methodologies included attempting to detect features by back-scattered light during the approach to Pluto (phase angle α ∼ 15°), in situ detection of impacting particles, a search for stellar occultations near the time of closest approach, and by forward-scattered light imaging during departure (α ∼ 165°). An extensive search using the Hubble Space Telescope (HST) prior to the encounter also contributed to the final ring limits. No rings, debris, or dust features were observed, but our new detection limits provide a substantially improved picture of the environment throughout the Pluto-Charon system. Searches for rings in back-scattered light covered the range 35,000-250,000 km from the system barycenter, a zone that starts interior to the orbit of Styx, the innermost minor satellite, and extends out to four times the orbital radius of Hydra, the outermost known satellite. We obtained our firmest limits using data from the New Horizons LORRI camera in the inner half of this region. Our limits on the normal I/F of an unseen ring depends on the radial scale of the rings: 2 ×10-8 (3σ) for 1500 km wide rings, 1 ×10-8 for 6000 km rings, and 7 ×10-9 for 12,000 km rings. Beyond ∼ 100, 000 km from Pluto, HST observations limit normal I/F to ∼ 8 ×10-8 . Searches for dust features from forward-scattered light extended from the surface of Pluto to the Pluto-Charon Hill sphere (rHill = 6.4 ×106 km). No evidence for rings or dust clouds was detected to normal I/F limits of ∼ 8.9 ×10-7 on ∼ 104 km scales. Four stellar occulation observations also probed the space interior to Hydra, but again no dust or debris was detected. The Student Dust Counter detected one particle impact 3.6 × 106 km from Pluto, but this is consistent with the interplanetary space environment established during the cruise of New Horizons. Elsewhere in the solar system, small moons commonly share their orbits with faint dust rings. Our results support recent dynamical studies suggesting that small grains are quickly lost from the Pluto-Charon system due to solar radiation pressure, whereas larger particles are orbitally unstable due to ongoing perturbations by the known moons.

A numerical investigation into the dynamics of Uranus' mu-ring

NASA Astrophysics Data System (ADS)

Kumar, K.; De Pater, I.; Showalter, M.

2017-12-01

Showalter and Lissauer (2006) reported the discovery of the nu-ring and mu-ring, located beyond Uranus' main ring system. Both faint, dusty rings are located interior to the large classical moons and were observed by co-adding Hubble Space Telescope (HST) images. The peak radial brightness of the mu-ring coincides with the orbit of Mab, a small moon discovered in 2003 by Showalter and Lissauer. Observations of the Mab/mu-ring system indicate a highly dynamic environment. The motion of Mab was determined to be anomalous over short time scales, with large position deviations computed with respect to a fitted precessing Keplerian ellipse. Numerical simulations to survey the possible cause of this anomalous motion hint at the possibility of interactions with a distribution of tens of bodies, below the HST detection threshold, in the neighborhood of Mab (Kumar, et al., 2016). Analysis of the mu-ring data has led to the discovery of peculiar features, leading to open questions about dust dynamics in the associated region around Uranus. Observations obtained using the HST and Keck telescopes reveal that the μ-ring is blue, indicative of a pre-dominance of sub-micron-sized particles (de Pater, et al., 2006). The only other blue ring detected in the Solar System is Saturn's E-ring, generated by plumes on Enceladus' south pole. The origin of the mu-ring however remains an open area of research. Mab is thought to be the likely source of the material in the mu-ring, with micrometeoroid impacts releasing material into orbit around Uranus, much like Jupiter's faint rings are regenerated by companion (small) moons (Burns et al. 1999). The mu-ring's blue color suggests however that there is an unknown mechanism at play that hides or removes large particles from the expected size distribution. We present results from a numerical investigation into the effects of gravitational and non-gravitational forces on the evolution of mu-ring dust particles. Following on from previous studies (Sfair and Giuliatti Winter, 2009; Sfair and Giuliatti Winter, 2012; Sfair, 2013; Hsu, et al., 2014), we generate statistics to provide insight into the lifetime of mu-ring dust. We utilize these results to analyze the possibility that the steep size distribution results from size-based sorting effects due to the natural environment.

Saturn's Rings, the Yarkovsky Effects, and the Ring of Fire

NASA Technical Reports Server (NTRS)

Rubincam, David Parry

2004-01-01

The dimensions of Saturn's A and B rings may be determined by the seasonal Yarkovsky effect and the Yarkovsky-Schach effect; the two effects confine the rings between approximately 1.68 and approximately 2.23 Saturn radii, in reasonable agreement with the observed values of 1.525 and 2.267. The C ring may be sparsely populated because its particles are transients on their way to Saturn; the infall may create a luminous Ring of Fire around Saturn's equator. The ring system may be young: in the past heat flow from Saturn's interior much above its present value would not permit rings to exist.

Cluster Inter-Spacecraft Communications

NASA Technical Reports Server (NTRS)

Cox, Brian

2008-01-01

A document describes a radio communication system being developed for exchanging data and sharing data-processing capabilities among spacecraft flying in formation. The system would establish a high-speed, low-latency, deterministic loop communication path connecting all the spacecraft in a cluster. The system would be a wireless version of a ring bus that complies with the Institute of Electrical and Electronics Engineers (IEEE) standard 1393 (which pertains to a spaceborne fiber-optic data bus enhancement to the IEEE standard developed at NASA's Jet Propulsion Laboratory). Every spacecraft in the cluster would be equipped with a ring-bus radio transceiver. The identity of a spacecraft would be established upon connection into the ring bus, and the spacecraft could be at any location in the ring communication sequence. In the event of failure of a spacecraft, the ring bus would reconfigure itself, bypassing a failed spacecraft. Similarly, the ring bus would reconfigure itself to accommodate a spacecraft newly added to the cluster or newly enabled or re-enabled. Thus, the ring bus would be scalable and robust. Reliability could be increased by launching, into the cluster, spare spacecraft to be activated in the event of failure of other spacecraft.

Vibration characteristics of two-stage planetary transmission system with thin-walled ring gear on elastic supports

NASA Astrophysics Data System (ADS)

Li, JianYing; Hu, QingChun; Zong, ChangFu; Zhu, TianJun; Zhang, ZeXing

2018-03-01

A dual-clutch and dual-speed planetary gears mechanism of a hybrid car coupled-system is taken as research subject, in which the ring gear of planet set II is a thin-walled structure and the clutch friction plates of planet set II are used as its elastic supports. Based on the lumped parameter-rigid elastic coupled dynamic model of two-stage planetary transmission system with thin-walled ring gear on elastic supports, the motion differential equations are established and the dynamic responses are solved by the Runge-Kutta method considering each stage internal and external time-varying mesh stiffness. The vibration displacements of each stage ring gear have been affected differently in time-domain, the translational vibration displacement of the ring gear of planet set I are obviously more than the torsional vibration displacement, but it is opposite for the ring gear of planet set II; The translational and torsional vibration responses of each stage ring gear arrive the peak in low-frequency. The analysis results of this paper can enrich the theoretical research of multistage planetary transmission and provide guidance for dynamic design.

Ring lens focusing and push-pull tracking scheme for optical disk systems

NASA Technical Reports Server (NTRS)

Gerber, R.; Zambuto, J.; Erwin, J. K.; Mansuripur, M.

1993-01-01

An experimental comparison of the ring lens and the astigmatic techniques of generating focus-error-signal (FES) in optical disk systems reveals that the ring lens generates a FES over two times steeper than that produced by the astigmat. Partly due to this large slope and, in part, because of its diffraction-limited behavior, the ring lens scheme exhibits superior performance characteristics. In particular the undesirable signal known as 'feedthrough' (induced on the FES by track-crossings during the seek operation) is lower by a factor of six compared to that observed with the astigmatic method. The ring lens is easy to align and has reasonable tolerance for positioning errors.

Charged dust in Saturn's magnetosphere

NASA Technical Reports Server (NTRS)

Mendis, D. A.; Hill, J. R.; Houpis, H. L. F.

1983-01-01

The overall distribution of fine dust in the Saturnian magnetosphere, its behavior, the cosmogony of the Saturnian ring system, and observations of the magnetosphere and ring system are synthesized and explained using gravito-electrodynamics. Among the phenomena discussed are the formation of waves in the F-ring, the cause of eccentricities of certain isolated ringlets, and the origin and morphology of the broad diffuse E-ring. Magnetogravitational resonance of charged dust with nearby satellites, gyro-orbital resonances, and magnetogravitational capture of exogenic dust by the magnetosphere are used to explain individual observations. The effect of a ring current associated with the charged dust is evaluated. Finally, the cosmogonic implications of the magnetogravitational theory are discussed.

Bushing retention system for thermal medium cooling delivery tubes in a gas turbine rotor

DOEpatents

Mashey, Thomas Charles

2002-01-01

Bushings are provided in counterbores for wheels and spacers for supporting thermal medium cooling tubes extending axially adjacent the rim of the gas turbine rotor. The retention system includes a retaining ring disposed in a groove adjacent an end face of the bushing and which retaining ring projects radially inwardly to prevent axial movement of the bushing in one direction. The retention ring has a plurality of circumferentially spaced tabs along its inner diameter whereby the ring is supported by the lands of the tube maintaining its bushing retention function, notwithstanding operation in high centrifugal fields and rotation of the ring in the groove into other circular orientations.

Reactor vessel support system. [LMFBR

DOEpatents

Golden, M.P.; Holley, J.C.

1980-05-09

A reactor vessel support system includes a support ring at the reactor top supported through a box ring on a ledge of the reactor containment. The box ring includes an annular space in the center of its cross-section to reduce heat flow and is keyed to the support ledge to transmit seismic forces from the reactor vessel to the containment structure. A coolant channel is provided at the outside circumference of the support ring to supply coolant gas through the keyways to channels between the reactor vessel and support ledge into the containment space.

Container lid gasket protective strip for double door transfer system

DOEpatents

Allen, Jr., Burgess M

2013-02-19

An apparatus and a process for forming a protective barrier seal along a "ring of concern" of a transfer container used with double door systems is provided. A protective substrate is supplied between a "ring of concern" and a safety cover in which an adhesive layer of the substrate engages the "ring of concern". A compressive foam strip along an opposite side of the substrate engages a safety cover such that a compressive force is maintained between the "ring of concern" and the adhesive layer of the substrate.

Uranus and the shape of elliptical rings

NASA Technical Reports Server (NTRS)

Lucke, R. L.

1978-01-01

It is reported that when the star SAO158687 passed behind the Uranus system, its light was occulted twice by the epsilon (fifth) ring of the planet. The first part of the ring to occult was about 100 km wide and the second part was about 40 km wide. The variable width of the ring is accounted for by differences in the orbital eccentricities of the individual particles composing the ring.

AXAF VETA-I mirror ring focus measurements

NASA Technical Reports Server (NTRS)

Tananbaum, H. D.; Zhao, P.

1994-01-01

The AXAF VETA-I mirror ring focus measurements were made with an HRI (microchannel plate) X-ray detector. The ring focus is a sharply focused ring formed by X-rays before they reach the VEAT-I focal plane. It is caused by spherical aberrations due to the finite source distance and the despace in the VETA-I test. The ring focus test reveals some aspects fo the test system distortions and the mirror surface figure which are difficult or impossible to detect at the focal plane. The test results show periodic modulations of the ring radius and width which could be caused by gravity, thermal, and/or epoxy shrinkage distortions. The strongest component of the modulation had a 12-fold symmetry, because these distortions were exerted on the mirror through 12 flexures of the VETA-I mount. Ring focus models were developed to simulate the ring image. The models were compared with the data to understand the test system distortions and the mirror glass imperfection. Further studies will be done to complete this work. The ring focus measurement is a very powerful test. We expect that a similar test for the finally assembled mirror of AXAD-I will be highly valuable.

Method of lining a vertical mine shaft with concrete

DOEpatents

Eklund, James D.; Halter, Joseph M.; Rasmussen, Donald E.; Sullivan, Robert G.; Moffat, Robert B.

1981-01-01

The apparatus includes a cylindrical retainer form spaced inwardly of the wall of the shaft by the desired thickness of the liner to be poured and having overlapping edges which seal against concrete flow but permit the form to be contracted to a smaller circumference after the liner has hardened and is self-supporting. A curb ring extends downwardly and outwardly toward the shaft wall from the bottom of the retainer form to define the bottom surface of each poured liner section. An inflatable toroid forms a seal between the curb ring and the shaft wall. A form support gripper ring having gripper shoes laterally extendable under hydraulic power to engage the shaft wall supports the retainer form, curb ring and liner until the newly poured liner section becomes self-supporting. Adjusting hydraulic cylinders permit the curb ring and retainer form to be properly aligned relative to the form support gripper ring. After a liner section is self-supporting, an advancing system advances the retainer form, curb ring and form support gripper ring toward a shaft boring machine above which the liner is being formed. The advancing system also provides correct horizontal alignment of the form support gripper ring.

Finite element analysis to compare complete denture and implant-retained overdentures with different attachment systems.

PubMed

Barão, Valentim Adelino Ricardo; Assunção, Wirley Gonçalves; Tabata, Lucas Fernando; Delben, Juliana Aparecida; Gomes, Erica Alves; de Sousa, Edson Antonio Capello; Rocha, Eduardo Passos

2009-07-01

This finite element analysis compared stress distribution on complete dentures and implant-retained overdentures with different attachment systems. Four models of edentulous mandible were constructed: group A (control), complete denture; group B, overdenture retained by 2 splinted implants with bar-clip system; group C, overdenture retained by 2 unsplinted implants with o'ring system; and group D, overdenture retained by 2 splinted implants with bar-clip and 2 distally placed o'ring system. Evaluation was performed on Ansys software, with 100-N vertical load applied on central incisive teeth. The lowest maximum general stress value (in megapascal) was observed in group A (64.305) followed by groups C (119.006), D (258.650), and B (349.873). The same trend occurred in supporting tissues with the highest stress value for cortical bone. Unsplinted implants associated with the o'ring attachment system showed the lowest maximum stress values among all overdenture groups. Furthermore, o'ring system also improved stress distribution when associated with bar-clip system.

Generation and propagation of a sine-azimuthal wavefront modulated Gaussian beam

PubMed Central

Lao, Guanming; Zhang, Zhaohui; Luo, Meilan; Zhao, Daomu

2016-01-01

We introduce a method for modulating the Gaussian beam by means of sine-azimuthal wavefront and carry out the experimental generation. The analytical propagation formula of such a beam passing through a paraxial ABCD optical system is derived, by which the intensity properties of the sine-azimuthal wavefront modulated Gaussian (SWMG) beam are examined both theoretically and experimentally. Both of the experimental and theoretical results show that the SWMG beam goes through the process from beam splitting to a Gaussian-like profile, which is closely determined by the phase factor and the propagation distance. Appropriate phase factor and short distance are helpful for the splitting of beam. However, in the cases of large phase factor and focal plane, the intensity distributions tend to take a Gaussian form. Such unique features may be of importance in particle trapping and medical applications. PMID:27443798

Lay agency and the generation of public-private mix health care maps.

PubMed

Meneses, Consuelo Sampaio; Cecilio, Luiz Carlos de Oliveira; Andreazza, Rosemarie; Carapinheiro, Graça; Andrade, Maria da Graça Garcia; Santiago, Sílvia Maria; Araújo, Eliane Cardoso; Souza, Ana Lúcia Medeiros; Reis, Denizi Oliveira; Pinto, Nicanor Rodrigues da Silva; Spedo, Sandra Maria

2017-06-01

This paper discusses part of the results obtained from a study carried out in two cities of the so-called ABCD Paulista Region in the period 2010-2012, in an attempt to spot the existence of non-state regulatory rationale towards access and consumption of health care services. The first stage includes interviews carried out with strategic stakeholders (managers and politicians) and key workers players. The second stage collected the stories of 18 very frequent users of health care services. This study revealed the leading role played by users to produce "health care maps", with emphasis on the frequent use of public and private resources in their itineraries, circumventing or merging with government regulation to obtain the care they need. The different formats of public-private mix transcend the still prevailing "official" concepts about the clear distinction between the two systems, which reveals the importance of this theme to public health management.

Botulinum neurotoxin vaccines: Past history and recent developments.

PubMed

Rusnak, Janice M; Smith, Leonard A

2009-12-01

Botulinum toxin may cause a neuroparalytic illness that may result in respiratory failure and require prolonged mechanical ventilation. As medical resources needed for supportive care of botulism in a bioterrorist event may quickly overwhelm the local healthcare systems, biodefense research efforts have been directed towards the development of a vaccine to prevent botulism. While human botulism has been caused only by toxin serotypes A, B, and E (rarely serotype F), all seven known immunologically distinct toxin serotypes (A - G) may potentially cause intoxication in humans from a bioterrorist event. A pentavalent (ABCDE) botulinum toxoid (PBT) has been administered as an investigation new drug (IND) to at-risk individuals for nearly 50 years. Due to declining immunogenicity of the PBT, research efforts have been directed at development of both improved (less local reactogenicity) botulinum toxoids and recombinant vaccines as potential vaccine candidates to replace the PBT.

West Nile virus infection in cats: ABCD guidelines on prevention and management.

PubMed

Egberink, Herman; Addie, Diane D; Boucraut-Baralon, Corine; Frymus, Tadeusz; Gruffydd-Jones, Tim; Hartmann, Katrin; Horzinek, Marian C; Hosie, Margaret J; Marsilio, Fulvio; Lloret, Albert; Lutz, Hans; Pennisi, Maria Grazia; Radford, Alan D; Thiry, Etienne; Truyen, Uwe; Möstl, Karin

2015-07-01

West Nile virus (WNV) is a zoonotic mosquito-borne virus with a broad host range that infects mainly birds and mosquitos, but also mammals (including humans), reptiles, amphibians and ticks. It is maintained in a bird-mosquito-bird transmission cycle. The most important vectors are bird-feeding mosquitos of the Culex genus; maintenance and amplification mainly involve passerine birds. WNV can cause disease in humans, horses and several species of birds following infection of the central nervous system. Cats can also be infected through mosquito bites, and by eating infected small mammals and probably also birds. Although seroprevalence in cats can be high in endemic areas, clinical disease and mortality are rarely reported. If a cat is suspected of clinical signs due to an acute WNV infection, symptomatic treatment is indicated. © Published by SAGE on behalf of ISFM and AAFP 2015.

A Reference Stack for PHM Architectures

DTIC Science & Technology

2014-10-02

components, fault modes and prognostics such as that described by MIMOSA (2009) and ISO 13374-3:2012 (2012). Section 2.6 described a semantic...architecture, and the use of a SOA is further discussed in Section 3.3.2. MIMOSA is a stack-oriented data architecture. Figure 11 shows its stack of...format (US Army PEWG, 2011). The tagging in ABCD format respects the data layers that are found in the MIMOSA standard ( MIMOSA , 2009) and in ISO

RF System Requirements for a Medium-Energy Electron-Ion Collider (MEIC) at JLab

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rimmer, Robert A; Hannon, Fay E; Guo, Jiquan

2015-09-01

JLab is studying options for a medium energy electron-ion collider that could fit on the JLab site and use CEBAF as a full-energy electron injector. A new ion source, linac and booster would be required, together with collider storage rings for the ions and electrons. In order to achieve the maximum luminosity these will be high-current storage rings with many bunches. We present the high-level RF system requirements for the storage rings, ion booster ring and high-energy ion beam cooling system, and describe the technology options under consideration to meet them. We also present options for staging that might reducemore » the initial capital cost while providing a smooth upgrade path to a higher final energy. The technologies under consideration may also be useful for other proposed storage ring colliders or ultimate light sources.« less

Transport electron through a quantum wire by side-attached asymmetric quantum-dot rings

NASA Astrophysics Data System (ADS)

Rostami, A.; Zabihi, S.; Rasooli S., H.; Seyyedi, S. K.

2011-12-01

The electronic conductance at zero temperature through a quantum wire with side-attached asymmetric quantum ring (as a scatter system) is theoretically studied using the non-interacting Anderson tunneling Hamiltonian method. We show that the asymmetric configuration of QD- scatter system strongly impresses the amplitude and spectrum of quantum wire nanostructure transmission characteristics. It is shown that whenever the balanced number of quantum dots in two rings is substituted by unbalanced scheme, the number of forbidden mini-bands in quantum wire conductance increases and QW-nanostructure electronic conductance contains rich spectral properties due to appearance of the new anti-resonance and resonance points in spectrum. Considering the suitable gap between nano-rings can strengthen the amplitude of new resonant peaks in the QW conductance spectrum. The proposed asymmetric quantum ring scatter system idea in this paper opens a new insight on designing quantum wire nano structure for given electronic conductance.

National Synchrotron Light Source II storage ring vacuum systems

DOE PAGES

Hseuh, Hsiao-Chaun; Hetzel, Charles; Leng, Shuwei; ...

2016-04-05

The National Synchrotron Light Source II, completed in 2014, is a 3-GeV synchrotron radiation (SR) facility at Brookhaven National Laboratory and has been in steady operation since. With a design electron current of 500 mA and subnanometer radians horizontal emittance, this 792-m circumference storage ring is providing the highest flux and brightness x-ray beam for SR users. Also, the majority of the storage ring vacuum chambers are made of extruded aluminium. Chamber sections are interconnected using low-impedance radiofrequency shielded bellows. SR from the bending magnets is intercepted by water-cooled compact photon absorbers resided in the storage ring chambers. Finally, thismore » paper presents the design of the storage ring vacuum system, the fabrication of vacuum chambers and other hardware, the installation, the commissioning, and the continuing beam conditioning of the vacuum systems.« less

Parallel Evolution of High-Level Aminoglycoside Resistance in Escherichia coli Under Low and High Mutation Supply Rates.

PubMed

Ibacache-Quiroga, Claudia; Oliveros, Juan C; Couce, Alejandro; Blázquez, Jesus

2018-01-01

Antibiotic resistance is a major concern in public health worldwide, thus there is much interest in characterizing the mutational pathways through which susceptible bacteria evolve resistance. Here we use experimental evolution to explore the mutational pathways toward aminoglycoside resistance, using gentamicin as a model, under low and high mutation supply rates. Our results show that both normo and hypermutable strains of Escherichia coli are able to develop resistance to drug dosages > 1,000-fold higher than the minimal inhibitory concentration for their ancestors. Interestingly, such level of resistance was often associated with changes in susceptibility to other antibiotics, most prominently with increased resistance to fosfomycin. Whole-genome sequencing revealed that all resistant derivatives presented diverse mutations in five common genetic elements: fhuA, fusA and the atpIBEFHAGDC, cyoABCDE , and potABCD operons. Despite the large number of mutations acquired, hypermutable strains did not pay, apparently, fitness cost. In contrast to recent studies, we found that the mutation supply rate mainly affected the speed (tempo) but not the pattern (mode) of evolution: both backgrounds acquired the mutations in the same order, although the hypermutator strain did it faster. This observation is compatible with the adaptive landscape for high-level gentamicin resistance being relatively smooth, with few local maxima; which might be a common feature among antibiotics for which resistance involves multiple loci.

Parallel Evolution of High-Level Aminoglycoside Resistance in Escherichia coli Under Low and High Mutation Supply Rates

PubMed Central

Ibacache-Quiroga, Claudia; Oliveros, Juan C.; Couce, Alejandro; Blázquez, Jesus

2018-01-01

Antibiotic resistance is a major concern in public health worldwide, thus there is much interest in characterizing the mutational pathways through which susceptible bacteria evolve resistance. Here we use experimental evolution to explore the mutational pathways toward aminoglycoside resistance, using gentamicin as a model, under low and high mutation supply rates. Our results show that both normo and hypermutable strains of Escherichia coli are able to develop resistance to drug dosages > 1,000-fold higher than the minimal inhibitory concentration for their ancestors. Interestingly, such level of resistance was often associated with changes in susceptibility to other antibiotics, most prominently with increased resistance to fosfomycin. Whole-genome sequencing revealed that all resistant derivatives presented diverse mutations in five common genetic elements: fhuA, fusA and the atpIBEFHAGDC, cyoABCDE, and potABCD operons. Despite the large number of mutations acquired, hypermutable strains did not pay, apparently, fitness cost. In contrast to recent studies, we found that the mutation supply rate mainly affected the speed (tempo) but not the pattern (mode) of evolution: both backgrounds acquired the mutations in the same order, although the hypermutator strain did it faster. This observation is compatible with the adaptive landscape for high-level gentamicin resistance being relatively smooth, with few local maxima; which might be a common feature among antibiotics for which resistance involves multiple loci. PMID:29615988

Lack of the PGA exopolysaccharide in Salmonella as an adaptive trait for survival in the host

PubMed Central

Echeverz, Maite; García, Begoña; Sabalza, Amaia; Valle, Jaione; Lasa, Iñigo

2017-01-01

Many bacteria build biofilm matrices using a conserved exopolysaccharide named PGA or PNAG (poly-β-1,6-N-acetyl-D-glucosamine). Interestingly, while E. coli and other members of the family Enterobacteriaceae encode the pgaABCD operon responsible for PGA synthesis, Salmonella lacks it. The evolutionary force driving this difference remains to be determined. Here, we report that Salmonella lost the pgaABCD operon after the divergence of Salmonella and Citrobacter clades, and previous to the diversification of the currently sequenced Salmonella strains. Reconstitution of the PGA machinery endows Salmonella with the capacity to produce PGA in a cyclic dimeric GMP (c-di-GMP) dependent manner. Outside the host, the PGA polysaccharide does not seem to provide any significant benefit to Salmonella: resistance against chlorine treatment, ultraviolet light irradiation, heavy metal stress and phage infection remained the same as in a strain producing cellulose, the main biofilm exopolysaccharide naturally produced by Salmonella. In contrast, PGA production proved to be deleterious to Salmonella survival inside the host, since it increased susceptibility to bile salts and oxidative stress, and hindered the capacity of S. Enteritidis to survive inside macrophages and to colonize extraintestinal organs, including the gallbladder. Altogether, our observations indicate that PGA is an antivirulence factor whose loss may have been a necessary event during Salmonella speciation to permit survival inside the host. PMID:28542593

The aux1 gene of the Ri plasmid is sufficient to confer auxin autotrophy in tobacco BY-2 cells.

PubMed

Nemoto, Keiichirou; Hara, Masamitsu; Goto, Shingo; Kasai, Kouji; Seki, Hikaru; Suzuki, Masashi; Oka, Atsuhiro; Muranaka, Toshiya; Mano, Yoshihiro

2009-05-01

Tobacco (Nicotiana tabacum) Bright Yellow-2 (BY-2) cells are rapidly proliferating meristematic cells that require auxin for culture in vitro. We have established several transgenic BY-2 cell lines that carry the T-DNA of Agrobacterium rhizogenes 15834, which harbors an agropine-type root-inducing (Ri) plasmid. Two of these lines, BYHR-3 and BYHR-7, were used to test the role of auxin in the proliferation of plant cells. The lines grew rapidly in Linsmaier-Skoog (LS) medium lacking auxin and other phytohormones. The TR-DNA, containing the aux1 (tryptophan monooxygenase) and aux2 (indoleacetamide hydrolase) genes, was present in the genomes of both transgenic lines, whereas the TL-DNA, containing the rolA, B, C and D genes, was present in the genome of BYHR-7 but not BYHR-3. Since the introduction of the rolABCD genes alone did not affect the auxin requirement of BY-2 cells, the aux1 and aux2 genes, but not the rolABCD genes, appear to be relevant to the auxin autotrophy of these transgenic lines. Furthermore, the overexpression of aux1 allowed BY-2 cells to grow rapidly in the absence of auxin, suggesting the existence in plant cells of an unidentified gene whose product is functionally equivalent or similar to that of aux2 of the Ri plasmid.

Do trauma courses change practice? A qualitative review of 20 courses in East, Central and Southern Africa.

PubMed

Ologunde, Rele; Le, Grace; Turner, Jim; Pandit, Hemant; Peter, Noel; Maurer, David; Hodgson, Sam; Larvin, Joseph; Lavy, Chris

2017-09-01

Trauma courses have been shown to improve clinical knowledge and patient outcomes. However, little is known about the individual drivers of change in practice amongst course participants in their home clinic environment. Front-line healthcare workers participated in a two-day Primary Trauma Care (PTC) course. Immediately after the course participants completed an evaluation survey on intended change in the management of trauma patients. Six months after the course, participants completed a survey on actual changes that had occurred. A total of 451 participants were sampled, with 321 responding at 6 months, from 40 courses across East, Central and Southern Africa. The most commonly reported intended change was the adoption of an ABCDE/systematic approach (53%). Six months after the course, 92.7% of respondents reported that they had made changes in their management, with adoption of an ABCDE/systematic approach (50.0%) remaining most common. 77% of participants reported an improvement in departmental trauma management, 26% reported an increase in staffing, 29% an increase in equipment and 68% of participants had gone on to train other healthcare workers in PTC. The findings suggest that PTC courses not only improve individual management of trauma patients but also but is also associated with beneficial effects for participants' host institutions with regards to staffing, equipment and training. Copyright © 2017 Elsevier Ltd. All rights reserved.

A Modified ABCDE Model of Flowering in Orchids Based on Gene Expression Profiling Studies of the Moth Orchid Phalaenopsis aphrodite

PubMed Central

Lee, Ann-Ying; Chen, Chun-Yi; Chang, Yao-Chien Alex; Chao, Ya-Ting; Shih, Ming-Che

2013-01-01

Previously we developed genomic resources for orchids, including transcriptomic analyses using next-generation sequencing techniques and construction of a web-based orchid genomic database. Here, we report a modified molecular model of flower development in the Orchidaceae based on functional analysis of gene expression profiles in Phalaenopsis aphrodite (a moth orchid) that revealed novel roles for the transcription factors involved in floral organ pattern formation. Phalaenopsis orchid floral organ-specific genes were identified by microarray analysis. Several critical transcription factors including AP3, PI, AP1 and AGL6, displayed distinct spatial distribution patterns. Phylogenetic analysis of orchid MADS box genes was conducted to infer the evolutionary relationship among floral organ-specific genes. The results suggest that gene duplication MADS box genes in orchid may have resulted in their gaining novel functions during evolution. Based on these analyses, a modified model of orchid flowering was proposed. Comparison of the expression profiles of flowers of a peloric mutant and wild-type Phalaenopsis orchid further identified genes associated with lip morphology and peloric effects. Large scale investigation of gene expression profiles revealed that homeotic genes from the ABCDE model of flower development classes A and B in the Phalaenopsis orchid have novel functions due to evolutionary diversification, and display differential expression patterns. PMID:24265826

Quantum mechanical design of efficient second-order nonlinear optical materials based on heteroaromatic imido-substituted hexamolybdates: first theoretical framework of POM-based heterocyclic aromatic rings.

PubMed

Janjua, Muhammad Ramzan Saeed Ashraf

2012-11-05

This work was inspired by a previous report (Janjua et al. J. Phys. Chem. A 2009, 113, 3576-3587) in which the nonlinear-optical (NLO) response strikingly improved with an increase in the conjugation path of the ligand and the nature of hexamolybdates (polyoxometalates, POMs) was changed into a donor by altering the direction of charge transfer with a second aromatic ring. Herein, the first theoretical framework of POM-based heteroaromatic rings is found to be another class of excellent NLO materials having double heteroaromatic rings. First hyperpolarizabilities of a large number of push-pull-substituted conjugated systems with heteroaromatic rings have been calculated. The β components were computed at the density functional theory (DFT) level (BP86 geometry optimizations and LB94 time-dependent DFT). The largest β values are obtained with a donor (hexamolybdates) on the benzene ring and an acceptor (-NO(2)) on pyrrole, thiophene, and furan rings. The pyrrole imido-substituted hexamolybdate (system 1c) has a considerably large first hyperpolarizability, 339.00 × 10(-30) esu, and it is larger than that of (arylimido)hexamolybdate, calculated as 0.302 × 10(-30) esu (reference system 1), because of the double aromatic rings in the heteroaromatic imido-substituted hexamolybdates. The heteroaromatic rings act as a conjugation bridge between the electron acceptor (-NO(2)) and donor (polyanion). The introduction of an electron donor into heteroaromatic rings significantly enhances the first hyperpolarizabilities because the electron-donating ability is substantially enhanced when the electron donor is attached to the heterocyclic aromatic rings. Interposing five-membered auxiliary fragments between strong donor (polyanion) or acceptor (-NO(2)) groups results in a large computed second-order NLO response. The present investigation provides important insight into the NLO properties of (heteroaromatic) imido-substituted hexamolybdate derivatives because these compounds exhibit enhanced hyperpolarizabilities compared to typical NLO arylimido hexamolybdates and heterocyclic aromatic rings reported in the literature.

ACCELERATORS: RF system design and measurement of HIRF-CSRe

NASA Astrophysics Data System (ADS)

Xu, Zhe; Zhao, Hong-Wei; Wang, Chun-Xiao; Xia, Jia-Wen; Zhan, Wen-Long; Bian, Zhi-Bin

2009-05-01

An RF system for the CSRe (cooling storage experimental ring) is designed and manufactured domestically. The present paper mainly describes the RF system design in five main sections: ferrite ring, RF cavity, RF generator, low level system and cavity cooling. The cavity is based on a type of coaxial resonator which is shorted at the end with one gap and loaded with domestic ferrite rings. The RF generator is designed in the push-pull mode and the low level control system is based on a DSP+FGPA+DDS+USB interface and has three feedback loops. Finally we give the results of the measurement on our system.

Use of Silica-Encapsulated Pseudomonas sp. Strain NCIB 9816-4 in Biodegradation of Novel Hydrocarbon Ring Structures Found in Hydraulic Fracturing Waters

PubMed Central

Aukema, Kelly G.; Kasinkas, Lisa; Aksan, Alptekin

2014-01-01

The most problematic hydrocarbons in hydraulic fracturing (fracking) wastewaters consist of fused, isolated, bridged, and spiro ring systems, and ring systems have been poorly studied with respect to biodegradation, prompting the testing here of six major ring structural subclasses using a well-characterized bacterium and a silica encapsulation system previously shown to enhance biodegradation. The direct biological oxygenation of spiro ring compounds was demonstrated here. These and other hydrocarbon ring compounds have previously been shown to be present in flow-back waters and waters produced from hydraulic fracturing operations. Pseudomonas sp. strain NCIB 9816-4, containing naphthalene dioxygenase, was selected for its broad substrate specificity, and it was demonstrated here to oxidize fundamental ring structures that are common in shale-derived waters but not previously investigated with this or related enzymes. Pseudomonas sp. NCIB 9816-4 was tested here in the presence of a silica encasement, a protocol that has previously been shown to protect bacteria against the extremes of salinity present in fracking wastewaters. These studies demonstrate the degradation of highly hydrophobic compounds by a silica-encapsulated model bacterium, demonstrate what it may not degrade, and contribute to knowledge of the full range of hydrocarbon ring compounds that can be oxidized using Pseudomonas sp. NCIB 9816-4. PMID:24907321

Development of a circular shape Si-PM-based detector ring for breast-dedicated PET system

NASA Astrophysics Data System (ADS)

Nakanishi, Kouhei; Yamamoto, Seiichi; Watabe, Hiroshi; Abe, Shinji; Fujita, Naotoshi; Kato, Katsuhiko

2018-02-01

In clinical situations, various breast-dedicated positron emission tomography (PET) systems have been used. However, clinical breast-dedicated PET systems have polygonal detector ring. Polygonal detector ring sometimes causes image artifact, so complicated reconstruction algorithm is needed to reduce artifact. Consequently, we developed a circular detector ring for breast-dedicated PET to obtain images without artifact using a simple reconstruction algorithm. We used Lu1.9Gd0.1SiO5 (LGSO) scintillator block which was made of 1.5 x 1.9 x 15 mm pixels that were arranged in an 8 x 24 matrix. As photodetectors, we used silicon photomultiplier (Si-PM) arrays whose channel size was 3 x 3 mm. A detector unit was composed of four scintillator blocks, 16 Si-PM arrays and a light guide. The developed detector unit had angled configuration since the light guide was bending. A detector unit had three gaps with an angle of 5.625° between scintillator blocks. With these configurations, we could arrange 64 scintillator blocks in nearly circular shape (regular 64-sided polygon) using 16 detector units. The use of the smaller number of detector units could reduce the size of the front-end electronics circuits. The inner diameter of the developed detector ring was 260 mm. This size was similar to those of brain PET systems, so our breast-dedicated PET detector ring can measure not only breast but also brain. Measured radial, tangential and axial spatial resolution of the detector ring reconstructed by the filtered back-projection (FBP) algorithm were 2.1 mm FWHM, 2.0 mm FWHM and 1.7 mm FWHM at center of field of view (FOV), respectively. The sensitivity was 2.0% at center of the axial FOV. With the developed detector ring, we could obtain high resolution image of the breast phantom and the brain phantom. We conclude that our developed Si-PM-based detector ring is promising for a high resolution breast-dedicated PET system that can also be used for brain PET system.

Non-Linear Dynamics of Saturn’s Rings

NASA Astrophysics Data System (ADS)

Esposito, Larry W.

2015-11-01

Non-linear processes can explain why Saturn’s rings are so active and dynamic. Ring systems differ from simple linear systems in two significant ways: 1. They are systems of granular material: where particle-to-particle collisions dominate; thus a kinetic, not a fluid description needed. We find that stresses are strikingly inhomogeneous and fluctuations are large compared to equilibrium. 2. They are strongly forced by resonances: which drive a non-linear response, pushing the system across thresholds that lead to persistent states.Some of this non-linearity is captured in a simple Predator-Prey Model: Periodic forcing from the moon causes streamline crowding; This damps the relative velocity, and allows aggregates to grow. About a quarter phase later, the aggregates stir the system to higher relative velocity and the limit cycle repeats each orbit.Summary of Halo Results: A predator-prey model for ring dynamics produces transient structures like ‘straw’ that can explain the halo structure and spectroscopy: This requires energetic collisions (v ≈ 10m/sec, with throw distances about 200km, implying objects of scale R ≈ 20km).Transform to Duffing Eqn : With the coordinate transformation, z = M2/3, the Predator-Prey equations can be combined to form a single second-order differential equation with harmonic resonance forcing.Ring dynamics and history implications: Moon-triggered clumping at perturbed regions in Saturn’s rings creates both high velocity dispersion and large aggregates at these distances, explaining both small and large particles observed there. We calculate the stationary size distribution using a cell-to-cell mapping procedure that converts the phase-plane trajectories to a Markov chain. Approximating the Markov chain as an asymmetric random walk with reflecting boundaries allows us to determine the power law index from results of numerical simulations in the tidal environment surrounding Saturn. Aggregates can explain many dynamic aspects of the rings and can renew rings by shielding and recycling the material within them, depending on how long the mass is sequestered. We can ask: Are Saturn’s rings a chaotic non-linear driven system?

Support System for Solar Receivers

NASA Technical Reports Server (NTRS)

Kiceniuk, T.

1985-01-01

Hinged split-ring mounts insure safe support of heavy receivers. In addition to safer operation and damage-free mounting system provides more accurate focusing, and small incremental adjustments of ring more easily made.

Novel stereocontrolled approach to syn- and anti-oxepene-cyclogeranyl trans-fused polycyclic systems: asymmetric total synthesis of (-)-Aplysistatin, (+)-Palisadin A, (+)-Palisadin B, (+)-12-hydroxy-palisadin B, and the AB ring system of adociasulfate-2 and toxicol A.

PubMed

Couladouros, Elias A; Vidali, Veroniki P

2004-08-06

A new stereocontrolled method for the formation of trans-anti cyclogeranyl-oxepene systems is described. The demanding stereochemistry is secured by stereoselective coupling of a cyclogeranyl tertiary alcohol with a 1,2-unsymmetrically substituted epoxide, while the formation of the highly strained oxepene is achieved employing ring-closing metathesis. Since the stereochemistry of the trans-fused 6,7-ring system is determined by the epoxide, the method also allows the construction of trans-syn 6,7-ring systems. This approach leads to the synthesis of the AB fragment of Adociasulfate-2 and Toxicol A, for the first time. The flexibility and efficiency of the presented strategy is demonstrated by the total asymmetric synthesis of (-)-Aplysistatin, (+)-Palisadin A, (+)-12-hydroxy-Palisadin B, and (+)-Palisadin B, employing two similar key intermediates.

Analysis of a Triple Star System Occulted By Saturn’s Rings

NASA Astrophysics Data System (ADS)

Bratcher, Allison; Colwell, J. E.; Bolin, B.

2012-10-01

On January 4, 2012, the Ultraviolet Imaging Spectrograph aboard the Cassini Spacecraft observed Saturn’s rings as they occulted the triple star system, Iota Orionis. Remarkably, the brightest star was occulted by the moon Prometheus, and we provide the timing information of first and last contact for navigation purposes and a chord across the moon. The large separation of the individual stars projected in the ring plane makes it possible to measure the profiles of narrow features in the rings as they were occulted by each of the three stars. This occultation thus provides a unique opportunity to measure short-scale longitudinal variations in narrow ringlets with stellar occultation data that usually provide only a single longitudinal sample. Iota Orionis has a low elevation angle (B=1.4 degrees) above the plane of the rings, enhancing the sensitivity of the occultation (by a factor of 1/sin(B)=41) to the optically thin regions of the rings such as the C Ring and the Cassini Division as well as faint ringlets in the Encke gap. We distinguished the three signals by creating a model triple star signal using data from another occultation. We were able to identify several faint, narrow ringlets, including two in the Encke gap, occulted by two of the three stars and more prominent ringlets, such as the Huygens ringlet, in all three stellar light curves. We present the equivalent widths of these ringlets in the data from this triple star system and limits on ring variability over the azimuthal separation of the stars that ranges from 6000 km at the inner C ring to 200 km at the outer A ring.

Multiple internal seal right micro-electro-mechanical system vacuum package

NASA Technical Reports Server (NTRS)

Shcheglov, Kirill V. (Inventor); Wiberg, Dean V. (Inventor); Hayworth, Ken J. (Inventor); Yee, Karl Y. (Inventor); Bae, Youngsam (Inventor); Challoner, A. Dorian (Inventor); Peay, Chris S. (Inventor)

2007-01-01

A Multiple Internal Seal Ring (MISR) Micro-Electro-Mechanical System (MEMS) vacuum package that hermetically seals MEMS devices using MISR. The method bonds a capping plate having metal seal rings to a base plate having metal seal rings by wafer bonding the capping plate wafer to the base plate wafer. Bulk electrodes may be used to provide conductive paths between the seal rings on the base plate and the capping plate. All seals are made using only metal-to-metal seal rings deposited on the polished surfaces of the base plate and capping plate wafers. However, multiple electrical feed-through metal traces are provided by fabricating via holes through the capping plate for electrical connection from the outside of the package through the via-holes to the inside of the package. Each metal seal ring serves the dual purposes of hermetic sealing and providing the electrical feed-through metal trace.

Cassini Radio Occultations of Saturn's Rings: Scattered Signal and Particle Sizes

NASA Astrophysics Data System (ADS)

Thomson, F.; Wong, K.; Marouf, E.; French, R.; Rappaport, N.; McGhee, C.; Anabtawi, A.; Asmar, S.; Barbinis, E.; Fleischman, D.; Goltz, G.; Johnston, D.; Rochblatt, D.

2005-08-01

Eight Cassini radio occultations of Saturn's rings were conducted from May 3 to September 5, 2005. During any given occultation, Cassini transmits Ka-, X-, and S-band sinusoidal signals (0.94, 3.6, and 13 cm-wavelength) through the rings. Spectral analysis of the perturbed signals received at stations of the Deep Space Network (DSN) reveals two distinct signal components. The first is the direct signal, a narrowband component representing the incident sinusoid emerging from the rings reduced in amplitude and changed in phase. The second is the scattered signal, a broadband component, representing near-forward scattering by ring particles. After reconstruction to remove diffraction effects, time history of the direct signal yields profiles of ring structure at resolution approaching ˜50 m. Of primary concern here is the broadband component. For the first time ever, clearly detectable scattered signals were observed at all three (Ka/X/S) bands. A single X/S radio occultation by Voyager 1 in 1980 detected scattered signal at X-band only, primarily because of the small ring opening angle B=5.9o at the time, compared with 19.1 ≤ B ≤ 23.6o for Cassini. Time histories of the observed spectra (spectrograms) and their dependence on wavelength provide important information about physical ring properties, including abundance of meter-size particles, particle crowding, clustering, spatial anisotropy, vertical ring profile and thickness. Cassini occultation orbits were optimized to map scattering by individual ring features into nearly non-overlapping spectral bands, allowing unambiguous identification of the contribution of ring features to the computed spectrograms. We present Ka/X/S spectrograms over the full extent of the ring system and relate their behavior to observed ring structure. The spectrograms imply presence of meters-size particles throughout the ring system. Preliminary results regarding the particle size distribution and vertical ring profile of selected ring features are presented. Contributions of personnel of the DSN are gratefully acknowledged.

Jupiter's Ring Halo

NASA Technical Reports Server (NTRS)

1997-01-01

A mosaic of four images taken through the clear filter (610 nanometers) of the solid state imaging (CCD) system aboard NASA's Galileo spacecraft on November 8, 1996, at a resolution of approximately 46 kilometers (km) per picture element (pixel) along the rings; however, because the spacecraft was only about 0.5 degrees above the ring plane, the image is highly foreshortened in the vertical direction. The images were obtained when Galileo was in Jupiter's shadow peering back toward the Sun; the ring was approximately 2,300,000 kilometers (km) away. The arc on the far right of the image is produced by sunlight scattered by small particles comprising Jupiter's upper atmospheric haze. The ring also efficiently scatters light, indicating that much of its brightness is due to particles that are microns or less in diameter. Such small particles are believed to have human-scale lifetimes, i.e., very brief compared to the solar system's age.

Jupiter's ring system is composed of three parts -- a flat main ring, a lenticular halo interior to the main ring, and the gossamer ring, which lies exterior to the main ring. The near and far arms of Jupiter's main ring extend horizontally across the mosaic, joining together at the ring's ansa, on the far left side of the figure. The near arm of the ring appears to be abruptly truncated close to the planet, at the point where it passes into Jupiter's shadow.

A faint mist of particles can be seen above and below the main rings; this vertically extended, toroidal 'halo' is unusual in planetary rings, and is probably caused by electromagnetic forces which can push small grains out of the ring plane. Halo material is present across this entire image, implying that it reaches more than 27,000 km above the ring plane. Because of shadowing, the halo is not visible close to Jupiter in the lower right part of the mosaic. In order to accentuate faint features in the image, different brightnesses are shown through color, with the brightest being white or yellow and the faintest purple.

The Jet Propulsion Laboratory, Pasadena, CA manages the mission for NASA's Office of Space Science, Washington, DC.

This image and other images and data received from Galileo are posted on the World Wide Web, on the Galileo mission home page at: http://galileo.jpl.nasa.gov. Background information and educational context for the images can be found at: http:/ /www.jpl.nasa.gov/galileo/sepo.

Capture, acceleration and bunching rf systems for the MEIC booster and storage rings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Shaoheng; Guo, Jiquan; Lin, Fanglei

2015-09-01

The Medium-energy Electron Ion Collider (MEIC), proposed by Jefferson Lab, consists of a series of accelerators. The electron collider ring accepts electrons from CEBAF at energies from 3 to 12 GeV. Protons and ions are delivered to a booster and captured in a long bunch before being ramped and transferred to the ion collider ring. The ion collider ring accelerates a small number of long ion bunches to colliding energy before they are re-bunched into a high frequency train of very short bunches for colliding. Two sets of low frequency RF systems are needed for the long ion bunch energymore » ramping in the booster and ion collider ring. Another two sets of high frequency RF cavities are needed for re-bunching in the ion collider ring and compensating synchrotron radiation energy loss in the electron collider ring. The requirements from energy ramping, ion beam bunching, electron beam energy compensation, collective effects, beam loading and feedback capability, RF power capability, etc. are presented. The preliminary designs of these RF systems are presented. Concepts for the baseline cavity and RF station configurations are described, as well as some options that may allow more flexible injection and acceleration schemes.« less

An innovative seismic bracing system based on a superelastic shape memory alloy ring

NASA Astrophysics Data System (ADS)

Gao, Nan; Jeon, Jong-Su; Hodgson, Darel E.; DesRoches, Reginald

2016-05-01

Shape memory alloys (SMAs) have great potential in seismic applications because of their remarkable superelasticity. Seismic bracing systems based on SMAs can mitigate the damage caused by earthquakes. The current study investigates a bracing system based on an SMA ring which is capable of both re-centering and energy dissipation. This lateral force resisting system is a cross-braced system consisting of an SMA ring and four tension-only cable assemblies, which can be applied to both new construction and seismic retrofit. The performance of this bracing system is examined through a quasi-static cyclic loading test and finite element (FE) analysis. This paper describes the experimental design in detail, discusses the experimental results, compares the performance with other bracing systems based on SMAs, and presents an Abaqus FE model calibrated on the basis of experimental results to simulate the superelastic behavior of the SMA ring. The experimental results indicate that the seismic performance of this system is promising in terms of damping and re-centering. The FE model can be used in the simulation of building structures using the proposed bracing system.

How Jupiter's Ring Was Discovered.

ERIC Educational Resources Information Center

Elliot, James; Kerr, Richard

1985-01-01

"Rings" (by astronomer James Elliot and science writer Richard Kerr) is a nontechnical book about the discovery and exploration of ring systems from the time of Galileo to the era of the Voyager spacecraft. One of this book's chapters is presented. (JN)

Toward Detection of Exoplanetary Rings via Transit Photometry: Methodology and a Possible Candidate

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aizawa, Masataka; Masuda, Kento; Suto, Yasushi

The detection of a planetary ring of exoplanets remains one of the most attractive, but challenging, goals in the field of exoplanetary science. We present a methodology that implements a systematic search for exoplanetary rings via transit photometry of long-period planets. This methodology relies on a precise integration scheme that we develop to compute a transit light curve of a ringed planet. We apply the methodology to 89 long-period planet candidates from the Kepler data so as to estimate, and/or set upper limits on, the parameters of possible rings. While the majority of our samples do not have sufficient signal-to-noise ratios (S/Ns) to place meaningfulmore » constraints on ring parameters, we find that six systems with higher S/Ns are inconsistent with the presence of a ring larger than 1.5 times the planetary radius, assuming a grazing orbit and a tilted ring. Furthermore, we identify five preliminary candidate systems whose light curves exhibit ring-like features. After removing four false positives due to the contamination from nearby stars, we identify KIC 10403228 as a reasonable candidate for a ringed planet. A systematic parameter fit of its light curve with a ringed planet model indicates two possible solutions corresponding to a Saturn-like planet with a tilted ring. There also remain two other possible scenarios accounting for the data; a circumstellar disk and a hierarchical triple. Due to large uncertain factors, we cannot choose one specific model among the three.« less

Gaseous toroid around Saturn. [Saturnian ring system for atomic hydrogen trapping in Titan atmospheric model

NASA Technical Reports Server (NTRS)

Mcdonough, T. R.

1974-01-01

The trapping of Titan's escaping atmosphere in the Saturnian system by a toroidal ring is discussed. The radius of the toroid is comparable to Titan's orbit, or about ten times larger than the visible rings. Theoretical atmospheric models are formulated that consider Saturn's gravitational attraction and magnetospheric properties in forming this toroid and in protecting toroid particles from direct ionization by solar wind particles.

Jupiter's Main Ring

NASA Technical Reports Server (NTRS)

1997-01-01

A mosaic of four images taken through the clear filter (610 nanometers) of the solid state imaging (CCD) system aboard NASA's Galileo spacecraft on November 8, 1996, at a resolution of approximately 46 kilometers (km) per picture element (pixel) along the rings; however, because the spacecraft was only about 0.5 degrees above the ring plane, the image is highly foreshortened in the vertical direction. The images were obtained when Galileo was in Jupiter's shadow peering back toward the Sun; the ring was approximately 2,300,000 kilometers (km) away. The arc on the far right of the image is produced by sunlight scattered by small particles comprising Jupiter's upper atmospheric haze. The ring also efficiently scatters light, indicating that much of its brightness is due to particles that are microns or less in diameter. Such small particles are believed to have human-scale lifetimes, i.e., very brief compared to the solar system's age.

Jupiter's ring system is composed of three parts -- a flat main ring, a lenticular halo interior to the main ring, and the gossamer ring, which lies exterior to the main ring. The near and far arms of Jupiter's main ring extend horizontally across the mosaic, joining together at the ring's ansa, on the far left side of the figure. The near arm of the ring appears to be abruptly truncated close to the planet, at the point where it passes into Jupiter's shadow. Some radial structure is barely visible across the ring's ansa. A faint mist of particles can be seen above and below the main rings; this vertically extended 'halo' is unusual in planetary rings, and is probably caused by electromagnetic forces pushing the smallest grains out of the ring plane. Because of shadowing, the halo is not visible close to Jupiter in the lower right part of the mosaic.

Jupiter's main ring is a thin strand of material encircling the planet. The diffuse innermost boundary begins at approximately 123,000 km. The main ring's outer radius is found to be at 128,940 +/-50 km, slightly less than the Voyager value of 129,130 +/-100 km, but very close to the orbit of the satellite Adrastea (128,980 km). The main ring exhibits a marked drop in brightness at 127,849 +/-50 km, lying almost atop the orbit of the Jovian moon Metis at 127,978 km. Satellites seem to affect the structure of even tenuous rings like that found at Jupiter.

The Jet Propulsion Laboratory, Pasadena, CA manages the mission for NASA's Office of Space Science, Washington, DC.

This image and other images and data received from Galileo are posted on the World Wide Web, on the Galileo mission home page at: http://galileo.jpl.nasa.gov. Background information and educational context for the images can be found at: http:/ /www.jpl.nasa.gov/galileo/sepo.

The two nerve rings of the hypostomal nervous system of Hydra vulgaris-an immunohistochemical analysis.

PubMed

Hufnagel, L A; Kass-Simon, G

2016-11-01

In Hydra vulgaris, physiological and pharmacological evidence exists for a hypostomal circumferential neuro-effector pathway that initiates ectodermal pacemaker activity at tentacular-hypostomal loci coordinating body and tentacle contractions. Here, we describe an ectodermal nerve ring that runs below and between the tentacles, and an anti-GABA B receptor antibody-labeled ring coincident with it. The location of this ring is consistent with the physiology of the hypostomal pacemaker systems of hydra. We also describe a distally located, ectodermal ring of nerve fibers that is not associated with anti-GABA B receptor antibody labeling. The neurites and cell bodies of sensory cells contribute to both rings. The location of the distal ring and its sensory cell neurites suggests an involvement in the behavior of the mouth. Between the two rings is a network of anastomosing sensory and ganglion cell bodies and their neurites. Phase contrast, darkfield, and antibody-labeled images reveal that the mouth of hydra comprises five or six epithelial folds whose endoderm extensively labels with anti-GABA B receptor antibody, suggesting that endodermal metabotrobic GABA receptors are also involved in regulating mouth behavior.

In vitro contraction of cytokinetic ring depends on myosin II but not on actin dynamics.

PubMed

Mishra, Mithilesh; Kashiwazaki, Jun; Takagi, Tomoko; Srinivasan, Ramanujam; Huang, Yinyi; Balasubramanian, Mohan K; Mabuchi, Issei

2013-07-01

Cytokinesis in many eukaryotes involves the contraction of an actomyosin-based contractile ring. However, the detailed mechanism of contractile ring contraction is not fully understood. Here, we establish an experimental system to study contraction of the ring to completion in vitro. We show that the contractile ring of permeabilized fission yeast cells undergoes rapid contraction in an ATP- and myosin-II-dependent manner in the absence of other cytoplasmic constituents. Surprisingly, neither actin polymerization nor its disassembly is required for contraction of the contractile ring, although addition of exogenous actin-crosslinking proteins blocks ring contraction. Using contractile rings generated from fission yeast cytokinesis mutants, we show that not all proteins required for assembly of the ring are required for its contraction in vitro. Our work provides the beginnings of the definition of a minimal contraction-competent cytokinetic ring apparatus.

Development, Testing, and Dissemination of Nonaversive Techniques for Working with Children with Autism: Demonstration of a "Best Practices" Model for Parents and Teachers. The A-B-C-D Model for Supporting Students with Autism (Antecedents, Behaviors, Consequences, Data). Final Report.

ERIC Educational Resources Information Center

Ikeda, Martin J.; Tucker, Richard; Rankin, Barbara

This final report describes the activities and outcomes of a federally funded project that was designed to develop, validate, and disseminate a training program for teachers of students with autism. The strategies taught to teachers were those that have been accepted as best practice in autism literature. Since 1996 more than 500 teachers,…

Saturn's Rings and Associated Ring Plasma Cavity: Evidence for Slow Ring Erosion

NASA Technical Reports Server (NTRS)

Farrell, W. M.; Kurth, W. S.; Gurnett, D. A.; Persoon, A. M.; MacDowall, R. J.

2017-01-01

We re-examine the radio and plasma wave observations obtained during the Cassini Saturn orbit insertion period, as the spacecraft flew over the northern ring surface into a radial distance of 1.3 Rs (over the C-ring). Voyager era studies suggest the rings are a source of micro-meteoroid generated plasma and dust, with theorized peak impact-created plasma outflows over the densest portion of the rings (central B-ring). In sharp contrast, the Cassini Radio and Plasma Wave System (RPWS) observations identify the presence of a ring-plasma cavity located in the central portion of the B-ring, with little evidence of impact-related plasma. While previous Voyager era studies have predicted unstable ion orbits over the C- ring, leading to field-aligned plasma transport to Saturns ionosphere, the Cassini RPWS observations do not reveal evidence for such instability-created plasma fountains. Given the passive ring loss processes observed by Cassini, we find that the ring lifetimes should extend >10(exp 9) years, and that there is limited evidence for prompt destruction (loss in <100 Myrs).

Saturn's rings and associated ring plasma cavity: Evidence for slow ring erosion

NASA Astrophysics Data System (ADS)

Farrell, W. M.; Kurth, W. S.; Gurnett, D. A.; Persoon, A. M.; MacDowall, R. J.

2017-08-01

We re-examine the radio and plasma wave observations obtained during the Cassini Saturn orbit insertion period, as the spacecraft flew over the northern ring surface into a radial distance of 1.3 Rs (over the C-ring). Voyager era studies suggest the rings are a source of micro-meteoroid generated plasma and dust, with theorized peak impact-created plasma outflows over the densest portion of the rings (central B-ring). In sharp contrast, the Cassini Radio and Plasma Wave System (RPWS) observations identify the presence of a ring-plasma cavity located in the central portion of the B-ring, with little evidence of impact-related plasma. While previous Voyager era studies have predicted unstable ion orbits over the C-ring, leading to field-aligned plasma transport to Saturn's ionosphere, the Cassini RPWS observations do not reveal evidence for such instability-created plasma 'fountains'. Given the passive ring loss processes observed by Cassini, we find that the ring lifetimes should extend >109 years, and that there is limited evidence for prompt destruction (loss in <100 Myrs).

Glove port retrofit assembly and method of replacing components

DOEpatents

Giesen, Isaac M; Cournoyer, Michael E; Rael, David G

2014-11-18

What is disclosed is a system for retrofitting a sealed enclosure for performing work therein having an outer enclosure assembly configured to be clamped to the outer annular face of a port ring and form a sealed engagement with the outer annular surface of the port ring, a change assembly having an inner ring and an access element wherein the inner ring has a first annular cylinder body that is sized to be slidably received by the port ring and the access element is configured to be sealably and slidably positioned within the first annular cylinder body of the inner ring.

Thermoelectric effect in Aharonov-Bohm structures.

PubMed

Lu, Xin; Wang, Jian-Sheng; Morrel, William G; Ni, Xiaoxi; Wu, Chang-Qin; Li, Baowen

2015-01-28

The thermoelectric effects of a single Aharonov-Bohm (SAB) ring and coupled double Aharonov-Bohm (DAB) rings have been investigated on a theoretical basis, taking into account the contributions of both electrons and phonons to the transport process by using the nonequilibrium Green's function technique. The thermoelectric figure of merit of the coupled DAB rings cannot be predicted directly by combining the values of two SAB ring systems due to the contribution of electron-phonon interaction to coupling between the two sites connecting the rings. We find that thermoelectric efficiency can be optimized by modulating the phases of the magnetic flux threading the two rings.

ARC-1986-A86-7032

NASA Image and Video Library

1986-01-24

P-29516 BW Range: 125, 000 kilometers (78,000 miles) Voyager 2's wide-angle camera captured this view of the outer part of the Uranian ring system just 11 minutes before passing though the ring plane. The resolution in this clear-filter view is slightly better than 9 km (6 mi). The brightest, outermost ring is known as epsilon. Interior to epsilon lie (from top) the newly discovered 10th ring of Uranus--designated 1986UR1 and barely visible here--and then the delta, gamma and eta rings.

Toroidal Geometry Stabilizing a Latitudinal Ring of Point Vortices on a Torus

NASA Astrophysics Data System (ADS)

Sakajo, Takashi; Shimizu, Yuuki

2018-06-01

We carry out the linear stability analysis of a polygonal ring configuration of N point vortices, called an N-ring, along the line of latitude θ _0 on a torus with the aspect ratio α . Deriving a criterion for the stability depending on the parameters N, θ _0 and α , we reveal how the aspect ratio α contributes to the stability of the N-ring. While the N-ring necessarily becomes unstable when N is sufficiently large for fixed α , the stability is closely associated with the geometric property of the torus for variable α ; for low aspect ratio α ˜ 1, N=7 is a critical number determining the stability of the N-ring when it is located along a certain range of latitudes, which is an analogous result to those in a plane and on a sphere. On the other hand, the stability is determined by the sign of curvature for high aspect ratio α ≫ 1. That is to say, the N-ring is neutrally stable if it is located on the inner side of the toroidal surface with a negative curvature, while the N-ring on its outer side with a positive curvature is unstable. Furthermore, based on the linear stability analysis, we describe nonlinear evolution of the N-ring when it becomes unstable. It is difficult to deal with this problem, since the evolution equation of the N point vortices is formulated as a Hamiltonian system with N degrees of freedom, which is in general non-integrable. Thus, we reduce the Hamiltonian system to a simple integrable system by introducing a cyclic symmetry. Owing to this reduction, we successfully find some periodic orbits in the reduced system, whose local bifurcations and global transitions for variable α are characterized in terms of the fundamental group of the torus.

Cycloalkyl-AminoMethylRhodamines: pH Dependent Photophysical Properties Tuned by Cycloalkane Ring Size

PubMed Central

Liu, Chuangjun; Best, Quinn A.; Suarez, Brian; Pertile, Jack; McCarroll, Matthew E.; Scott, Colleen N.

2015-01-01

A series of fluorescent pH probes based on the spiro-cyclic rhodamine core, aminomethylrhodamines (AMR), was synthesized and the effect of cycloalkane ring size on the acid/base properties of the AMR system was explored. The study involved a series of rhodamine 6G (cAMR6G) and rhodamine B (cAMR) pH probes with cycloalkane ring sizes from C-3 to C-6 on the spiro-cyclic amino group. It is known that the pKa value of cycloalkylamines can be tuned by the different ring sizes in accordance with the Baeyer ring strain theory. Smaller ring amines have lower pKa value, i.e. they're less basic, such that the relative order in cycloalkylamine basicity is: cyclohexyl>cyclopentyl>cyclobutyl>cyclopropyl. Herein, it was found that the pKa values of the cAMR and cAMR6G systems can also be predicted by Baeyer ring strain theory. The pKa values for the cAMR6G series were shown to be higher than the cAMR series by a value of approximately 1. PMID:25686771

Encounter with Saturn: Voyager 1 imaging science results

USGS Publications Warehouse

Smith, B.A.; Soderblom, L.; Beebe, R.; Boyce, J.; Briggs, G.; Bunker, A.; Collins, S.A.; Hansen, C.J.; Johnson, T.V.; Mitchell, J.L.; Terrile, R.J.; Carr, M.; Cook, A.F.; Cuzzi, J.; Pollack, James B.; Danielson, G. Edward; Ingersoll, A.; Davies, M.E.; Hunt, G.E.; Masursky, H.; Shoemaker, E.; Morrison, D.; Owen, Timothy W.; Sagan, C.; Veverka, J.; Strom, R.; Suomi, V.E.

1981-01-01

As Voyager 1 flew through the Saturn system it returned photographs revealing many new and surprising characteristics of this complicated community of bodies. Saturn's atmosphere has numerous, low-contrast, discrete cloud features and a pattern of circulation significantly different from that of Jupiter. Titan is shrouded in a haze layer that varies in thickness and appearance. Among the icy satellites there is considerable variety in density, albedo, and surface morphology and substantial evidence for endogenic surface modification. Trends in density and crater characteristics are quite unlike those of the Galilean satellites. Small inner satellites, three of which were discovered in Voyager images, interact gravitationally with one another and with the ring particles in ways not observed elsewhere in the solar system. Saturn's broad A, B, and C rings contain hundreds of "ringlets," and in the densest portion of the B ring there are numerous nonaxisymmetric features. The narrow F ring has three components which, in at least one instance, are kinked and crisscrossed. Two rings are observed beyond the F ring, and material is seen between the C ring and the planet. Copyright ?? 1981 AAAS.

Internal V-Band Clamp

DOEpatents

Vaughn, Mark R.; Hafenrichter, Everett S.; Chapa, Agapito C.; Harris, Steven M.; Martinez, Marcus J.; Baty, Roy S.

2006-02-28

A system for clamping two tubular members together in an end-to-end relationship uses a split ring with a V-shaped outer rim that can engage a clamping surface on each member. The split ring has a relaxed closed state where the ends of the ring are adjacent and the outside diameter of the split ring is less than the minimum inside diameter of the members at their ends. The members are clamped when the split ring is spread into an elastically stretched position where the ring rim is pressed tightly against the interior surfaces of the members. Mechanisms are provided for removing the spreader so the split ring will return to the relaxed state, releasing the clamped members.

An Alternative Derivation of the Energy Levels of the "Particle on a Ring" System

NASA Astrophysics Data System (ADS)

Vincent, Alan

1996-10-01

All acceptable wave functions must be continuous mathematical functions. This criterion limits the acceptable functions for a particle in a linear 1-dimensional box to sine functions. If, however, the linear box is bent round into a ring, acceptable wave functions are those which are continuous at the 'join'. On this model some acceptable linear functions become unacceptable for the ring and some unacceptable cosine functions become acceptable. This approach can be used to produce a straightforward derivation of the energy levels and wave functions of the particle on a ring. These simple wave mechanical systems can be used as models of linear and cyclic delocalised systems such as conjugated hydrocarbons or the benzene ring. The promotion energy of an electron can then be used to calculate the wavelength of absorption of uv light. The simple model gives results of the correct order of magnitude and shows that, as the chain length increases, the uv maximum moves to longer wavelengths, as found experimentally.

Ring-Resonator/Sol-Gel Interferometric Immunosensor

NASA Technical Reports Server (NTRS)

Bearman, Gregory; Cohen, David

2007-01-01

A proposed biosensing system would be based on a combination of (1) a sensing volume containing antibodies immobilized in a sol-gel matrix and (2) an optical interferometer having a ring resonator configuration. The antibodies would be specific to an antigen species that one seeks to detect. In the ring resonator of the proposed system, light would make multiple passes through the sensing volume, affording greater interaction length and, hence, greater antibody- detection sensitivity.

Saturn's E, G, and F rings - Modulated by the plasma sheet?

NASA Technical Reports Server (NTRS)

Morfill, G. E.; Gruen, E.; Johnson, T. V.

1983-01-01

Saturn's broad E ring, the narrow G ring, and the structured and apparently time-variable F ring(s) contain many micron and submicron-sized particles, which make up the 'visible' component. These rings (or ring systems) are in direct contact with magnetospheric plasma. Fluctuations in the plasma density and/or mean energy, due to magnetospheric and solar wind processes, may induce stochastic charge variations on the dust particles, which in turn lead to an orbit perturbation and spatial diffusion. In addition, Coulomb drag forces may be important, in particular for the E ring. The possibility that electromagnetic effects may play a role in determining the F ring structure and its possible time variations is critically examined. Sputtering of micron-sized dust particles in the E ring by magnetospheric ions yields lifetimes of 100 to 10,000 years. This effect as well as the plasma induced transport processes require an active source for the E ring, probably Enceladus.

Problems of gaseous motion around stars

NASA Technical Reports Server (NTRS)

Huang, S.-S.

1973-01-01

A distinction is drawn between radial and tangential modes of ejection from stars, and the possible flow patterns are described. They are: expanding streams, falling streams, jet streams, circulatory streams, and gaseous envelopes. Motion around Be stars is discussed at some length, as a preliminary to studying more complicated flow in binary systems. The rotational velocity of the Be star is insufficient to form the ring. It appears likely that radial instability is temperature sensitive. Rings and disks in binary systems are discussed from the point of view of periodic orbits for particles within the gravitational field of such a system. The formation of these rings is discussed. The expected relation between rotational velocity of the ring and the orbital period is discussed. The relation of circumstellar streams to period changes is mentioned. Finally, the influence of magnetic fields on the circumstellar material and the system is discussed.

Auto-production of biosurfactants reverses the coffee ring effect in a bacterial system

NASA Astrophysics Data System (ADS)

Sempels, Wouter; de Dier, Raf; Mizuno, Hideaki; Hofkens, Johan; Vermant, Jan

2013-04-01

The deposition of material at the edge of evaporating droplets, known as the ‘coffee ring effect’, is caused by a radially outward capillary flow. This phenomenon is common to a wide array of systems including colloidal and bacterial systems. The role of surfactants in counteracting these coffee ring depositions is related to the occurrence of local vortices known as Marangoni eddies. Here we show that these swirling flows are universal, and not only lead to a uniform deposition of colloids but also occur in living bacterial systems. Experiments on Pseudomonas aeruginosa suggest that the auto-production of biosurfactants has an essential role in creating a homogeneous deposition of the bacteria upon drying. Moreover, at biologically relevant conditions, intricate time-dependent flows are observed in addition to the vortex regime, which are also effective in reversing the coffee ring effect at even lower surfactant concentrations.

Aberrated laser beams in terms of Zernike polynomials

NASA Astrophysics Data System (ADS)

Alda, Javier; Alonso, Jose; Bernabeu, Eusebio

1996-11-01

The characterization of light beams has devoted a lot of attention in the past decade. Several formalisms have been presented to treat the problem of parameter invariance and characterization in the propagation of light beam along ideal, ABCD, optical systems. The hard and soft apertured optical systems have been treated too. Also some aberrations have been analyzed, but it has not appeared a formalism able to treat the problem as a whole. In this contribution we use a classical approach to describe the problem of aberrated, and therefore apertured, light beams. The wavefront aberration is included in a pure phase term expanded in terms of the Zernike polynomials. Then, we can use the relation between the lower order Zernike polynomia and the Seidel or third order aberrations. We analyze the astigmatism, the spherical aberration and the coma, and we show how higher order aberrations can be taken into account. We have calculated the divergence, and the radius of curvature of such aberrated beams and the influence of these aberrations in the quality of the light beam. Some numerical simulations have been done to illustrate the method.

Recipe for generating Weyl semimetals with extended topologically protected features

NASA Astrophysics Data System (ADS)

Wang, R.; Zhao, J. Z.; Jin, Y. J.; Xu, W. P.; Gan, L.-Y.; Wu, X. Z.; Xu, H.; Tong, S. Y.

2017-09-01

We present a recipe that leads to Weyl semimetals with extended topologically protected features. We show that compounds in a family that possess time-reversal symmetry and share a noncentrosymmetric cubic structure with the space group F -43 m (no. 216) host robust Weyl fermions with extended and easily measurable protected features. The candidates in this family are compounds with different chemical formulas, A B2 , ABC, AB C2 , and ABCD, and their Fermi levels are predominantly populated by nontrivial Weyl fermions. Symmetry of the system requires that the Weyl nodes with opposite chirality are well separated in momentum space. Adjacent Weyl points have the same chirality; thus these Weyl nodes would not annihilate each other with respect to lattice perturbations. As Fermi arcs and surface states connect Weyl nodes with opposite chirality, the large separation of the latter in momentum space guarantees the appearance of very long arcs and surface states. This work demonstrates that the use of system symmetry by first-principles calculations is a powerful approach for discovering new Weyl semimetals with attractive features whose protected fermions may be candidates of many applications.

Sporotrichosis in cats: ABCD guidelines on prevention and management.

PubMed

Lloret, Albert; Hartmann, Katrin; Pennisi, Maria Grazia; Ferrer, Lluis; Addie, Diane; Belák, Sándor; Boucraut-Baralon, Corine; Egberink, Herman; Frymus, Tadeusz; Gruffydd-Jones, Tim; Hosie, Margaret J; Lutz, Hans; Marsilio, Fulvio; Möstl, Karin; Radford, Alan D; Thiry, Etienne; Truyen, Uwe; Horzinek, Marian C

2013-07-01

Sporotrichosis is an important subcutaneous fungal infection of humans and animals in some endemic tropical and subtropical areas. Among domestic species, cats are the most frequently infected. The primary mode of transmission is traumatic inoculation of fungal conidia from plants and soil. Contact with infected cats is the major mode of transmission to humans, especially in endemic areas like Brazil, where a large epidemic has occurred in the past decade. Most cases in cats are cutaneous, presenting as multiple ulcerated nodules and draining tracts in the skin. Lymphadenopathy, respiratory signs and systemic dissemination may also occur. Diagnosis is based on fungal detection by cytology and/or histology, and confirmation by culture. Treatment consists of at least 2 months' systemic antifungal therapy, with itraconazole as the first-choice agent. The prognosis is favourable provided there is good owner compliance and adverse drug effects do not occur. Contact with infected cats carries a high zoonotic risk. Cat owners travelling to endemic areas should be warned and advised to keep their cats indoors to prevent infection. Professionals must wear gloves when handling cats with skin nodules and ulcers and dealing with diagnostic samples.

Statistical Ring Catenation under Thermodynamic Control: Should the Jacobson-Stockmayer Cyclization Theory Take into Account Catenane Formation?

PubMed

Di Stefano, Stefano; Ercolani, Gianfranco

2017-01-26

An extension of the Jacobson-Stockmayer theory is presented to include the reversible formation of [2]catenanes in a ring-chain system under thermodynamic control. The extended theory is based on the molar catenation constant, measuring the ease of catenation of two ring oligomers, whose expression was obtained in a previous work. Two scenarios have been considered: that of "thick" (hydrocarbon-like) chains and that of "thin" (DNA-like) chains. In the case of "thick" chains, the formation of catenanes can be neglected, unless in the unlikely case of a very large value of the equilibrium constant for linear propagation (K ≈ 10 8 mol -1 L, or larger). For K tending to infinity, the system becomes a chain-free system where only ring-catenane equilibria occur. Under this condition, there is a critical concentration below which only rings are present at equilibrium and above which the ring fraction remains constant, and the excess monomer is converted only into catenanes. In the case of "thin" chains, the formation of catenanes cannot be neglected even for values of K as low as 10 2 mol -1 L, thus justifying the use of the extended theory.

Beam diagnostics at high-intensity storage rings

NASA Astrophysics Data System (ADS)

Plum, Mike

1994-10-01

Beam diagnostics at high-intensity facilities feature their own special set of problems and characteristics, issues peculiar to high-intensity storage rings include beam loss, beam halos, extraction efficiency, beam in the gap, clearing electrodes, and beam-profile measurement. The Los Alamos Proton Storage Ring (PSR) is a nice example of a high-intensity storage ring. I will discuss in some detail three diagnostic systems currently in use at the PSR: the beam-loss-monitor system, the electron-clearing system, and the beam-in-the-gap monitor. Much of our discussion is inspired by the problems we have encountered and the useful things we have learned while commissioning and developing the PSR. Another inspiration is our work on the next-generation neutron-spallation source, also known as the National Center for Neutron Research (NCNR).

Clump detections and limits on moons in Jupiter's ring system.

PubMed

Showalter, Mark R; Cheng, Andrew F; Weaver, Harold A; Stern, S Alan; Spencer, John R; Throop, Henry B; Birath, Emma M; Rose, Debi; Moore, Jeffrey M

2007-10-12

The dusty jovian ring system must be replenished continuously from embedded source bodies. The New Horizons spacecraft has performed a comprehensive search for kilometer-sized moons within the system, which might have revealed the larger members of this population. No new moons were found, however, indicating a sharp cutoff in the population of jovian bodies smaller than 8-kilometer-radius Adrastea. However, the search revealed two families of clumps in the main ring: one close pair and one cluster of three to five. All orbit within a brighter ringlet just interior to Adrastea. Their properties are very different from those of the few other clumpy rings known; the origin and nonrandom distribution of these features remain unexplained, but resonant confinement by Metis may play a role.

Rotating machinery dynamics simulation. I. Rigid systems with ball bearing nonlinearities and outer ring ovality under rotating unbalance excitation

PubMed

el-Saeidy

2000-02-01

The radial clearance in rolling bearing systems, required to compensate for dimensional changes associated with thermal expansion of the various parts during operation, may cause dimensional attrition and comprise bearing life, if unloaded operation occurs and balls skid [D. Childs and D. Moyer, ASME J. Eng. Gas Turb. Power 107, 152-159 (1985)]. Also, it can cause jumps in the response to unbalance excitation. These undesirable effects may be eliminated by introducing two or more loops into one of the bearing races so that at least two points of the ring circumference provide a positive zero clearance [D. Childs, Handbook of Rotordynamics, edited by F. Ehrich (McGraw-Hill, NY, 1992)]. The deviation of the outer ring with two loops, known as ovality, is one of the bearing distributed defects. Although this class of imperfections has received much work, none of the available studies has simulated the effect of the outer ring ovality on the dynamic behavior of rotating machinery under rotating unbalance with consideration of ball bearing nonlinearities, shaft elasticity, and speed of rotation. To fill this gap, the equations of motion of a rotor-ball bearing system are formulated using finite-elements (FE) discretization and Lagrange's equations. The analyses are specialized to a rigid-rotor system, by retaining the rigid body modes only in the FE solution. Samples of the results are presented in both time domain and frequency domain for a system with and without outer ring ovality. It is found that with ideal bearings (no ovality), the vibration spectrum is qualitatively and quantitatively the same in both the horizontal and vertical directions. When the ring ovality is introduced, however, the spectrum in both orthogonal planes is no longer similar. And magnitude of the bearing load has increased in the form of repeated random impacts, between balls and rings, in the horizontal direction (direction of maximum clearance) compared to a continuous contact along the vertical direction (direction of positive zero clearance). This underlines the importance of the vibration measuring probe's direction, with respect to the outer ring axes, to capture impact-induced vibrations. Moreover, when the harmonic excitation is increased for a system with ideal bearings, the spectral peaks above forcing frequency have shifted to a higher-frequency region, indicating some sort of a hard spring mechanism inherent in the system. Another observation, is that for the same external excitation, vibration amplitude at forcing frequency in the bearing force spectrum is the same for systems with or without outer ring ovality.

77 FR 52264 - Airworthiness Directives; Hughes Helicopters, Inc., and McDonnell Douglas Helicopter Systems...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-29

... contained an improperly installed frame ring at station 209.78. The frame rings were installed with too short a distance between an aft longeron rivet and the outboard edge of the frame ring. This is known as....78 canted frame ring to the center of the No. 1 and No. 2 aft rivet locations on each of the four...

Towards an Understanding of Thermal Throughput across Saturn's Rings with Cassini CIRS

NASA Astrophysics Data System (ADS)

Brooks, S. M.; Spilker, L. J.

2015-12-01

One of the more striking aspects of Saturn's main ring system is its aspect ratio. It spans over 270,000 km from ansa to ansa, yet its thickness normal to the ring plane is less than a million times its breadth. Hence, studies of the rings' structure focus mostly on radial and azimuthal features. But in the thermal infrared the vertical thickness of the main rings is clearly manifest in the measured temperature differences between that face of the rings exposed to direct solar illumination (the lit face) and the opposite (unlit) face derived from observations with Cassini's Composite Infrared Spectrometer (CIRS). Ferrari et al. (2013) and Pilorz et al. (2015) have recently published insightful and thorough analyses of the thermal throughput across the optically thick B ring. The ultimate goal of this work is to understand these lit/unlit temperature differentials and their variation with radius and optical depth across the entire ring system. As previous work has shown (Spilker et al., 2006), the thermal flux from Saturn's rings observed by CIRS is a function of observing geometry. To control for these variations, we designed paired observations of the lit and unlit rings where observing variables such as the emission, phase and local hour angles were kept as similar as possible to facilitate direct comparison between the lit and unlit observations. Constraining the amount of thermal energy exchange between the lit and unlit sides of the rings will allow us to learn about the main rings' structure and dynamics in this third dimension. This presentation is a progress report on our analysis of such observations and our plans for future work. This research was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under contract with NASA. Copyright 2015 California Institute of Technology. Government sponsorship acknowledged.

Slowing down of ring polymer diffusion caused by inter-ring threading.

PubMed

Lee, Eunsang; Kim, Soree; Jung, YounJoon

2015-06-01

Diffusion of long ring polymers in a melt is much slower than the reorganization of their internal structures. While direct evidence for entanglements has not been observed in the long ring polymers unlike linear polymer melts, threading between the rings is suspected to be the main reason for slowing down of ring polymer diffusion. It is, however, difficult to define the threading configuration between two rings because the rings have no chain end. In this work, evidence for threading dynamics of ring polymers is presented by using molecular dynamics simulation and applying a novel analysis method. The simulation results are analyzed in terms of the statistics of persistence and exchange times that have proved useful in studying heterogeneous dynamics of glassy systems. It is found that the threading time of ring polymer melts increases more rapidly with the degree of polymerization than that of linear polymer melts. This indicates that threaded ring polymers cannot diffuse until an unthreading event occurs, which results in the slowing down of ring polymer diffusion. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Modified Cooling System for Low Temperature Experiments in a 3000 Ton Multi-Anvil Press

NASA Astrophysics Data System (ADS)

Secco, R.; Yong, W.

2017-12-01

A new modified cooling system for a 3000-ton multi-anvil press has been developed to reach temperatures below room temperature at high pressures. The new system is much simpler in design, easier to make and use, and has the same cooling capability as the previous design (Secco and Yong, RSI, 2016). The key component of the new system is a steel ring surrounding the module wedges that contains liquid nitrogen (LN2) which flows freely through an entrance port to flood the interior of the pressure module. Upper and lower O-rings on the ring seal in the liquid while permitting modest compression and an thermally insulating layer of foam is attached to the outside of the ring. The same temperature of 220 K reached with two different cooling systems suggests that thermal equilibrium is reached between the removal of heat by LN2 and the influx of heat through the massive steel components of this press.

NEUTRONIC REACTOR SYSTEM

DOEpatents

Treshow, M.

1959-02-10

A reactor system incorporating a reactor of the heterogeneous boiling water type is described. The reactor is comprised essentially of a core submerged adwater in the lower half of a pressure vessel and two distribution rings connected to a source of water are disposed within the pressure vessel above the reactor core, the lower distribution ring being submerged adjacent to the uppcr end of the reactor core and the other distribution ring being located adjacent to the top of the pressure vessel. A feed-water control valve, responsive to the steam demand of the load, is provided in the feedwater line to the distribution rings and regulates the amount of feed water flowing to each distribution ring, the proportion of water flowing to the submerged distribution ring being proportional to the steam demand of the load. This invention provides an automatic means exterior to the reactor to control the reactivity of the reactor over relatively long periods of time without relying upon movement of control rods or of other moving parts within the reactor structure.

Research in Applied Mathematics Related to Mathematical System Theory.

DTIC Science & Technology

1977-06-01

This report deals with research results obtained in the field of mathematical system theory . Special emphasis was given to the following areas: (1...Linear system theory over a field: parametrization of multi-input, multi-output systems and the geometric structure of classes of systems of...constant dimension. (2) Linear systems over a ring: development of the theory for very general classes of rings. (3) Nonlinear system theory : basic

Stress analysis in oral obturator prostheses, part II: photoelastic imaging

NASA Astrophysics Data System (ADS)

Pesqueira, Aldiéris Alves; Goiato, Marcelo Coelho; da Silva, Emily Vivianne Freitas; Haddad, Marcela Filié; Moreno, Amália; Zahoui, Abbas; dos Santos, Daniela Micheline

2014-06-01

In part I of the study, two attachment systems [O-ring; bar-clip (BC)] were used, and the system with three individualized O-rings provided the lowest stress on the implants and the support tissues. Therefore, the aim of this study was to assess the stress distribution, through the photoelastic method, on implant-retained palatal obturator prostheses associated with different attachment systems: BOC-splinted implants with a bar connected to two centrally placed O-rings, and BOD-splinted implants with a BC connected to two distally placed O-rings (cantilever). One photoelastic model of the maxilla with oral-sinus-nasal communication with three parallel implants was fabricated. Afterward, two implant-retained palatal obturator prostheses with the two attachment systems described above were constructed. Each assembly was positioned in a circular polariscope and a 100-N axial load was applied in three different regions with implants by using a universal testing machine. The results were obtained through photograph record analysis of stress. The BOD system exhibited the highest stress concentration, followed by the BOC system. The O-ring, centrally placed on the bar, allows higher mobility of the prostheses and homogeneously distributes the stress to the region of the alveolar ridge and implants. It can be concluded that the use of implants with O-rings, isolated or connected with a bar, to rehabilitate maxillectomized patients allows higher prosthesis mobility and homogeneously distributes the stress to the alveolar ridge region, which may result in greater chewing stress distribution to implants and bone tissue. The clinical implication of the augmented bone support loss after maxillectomy is the increase of stress in the attachment systems and, consequently, a higher tendency for displacement of the prosthesis.

Non-Linear Dynamics of Saturn's Rings

NASA Astrophysics Data System (ADS)

Esposito, L. W.

2016-12-01

Non-linear processes can explain why Saturn's rings are so active and dynamic. Ring systems differ from simple linear systems in two significant ways: 1. They are systems of granular material: where particle-to-particle collisions dominate; thus a kinetic, not a fluid description needed. Stresses are strikingly inhomogeneous and fluctuations are large compared to equilibrium. 2. They are strongly forced by resonances: which drive a non-linear response, that push the system across thresholds that lead to persistent states. Some of this non-linearity is captured in a simple Predator-Prey Model: Periodic forcing from the moon causes streamline crowding; This damps the relative velocity. About a quarter phase later, the aggregates stir the system to higher relative velocity and the limit cycle repeats each orbit, with relative velocity ranging from nearly zero to a multiple of the orbit average. Summary of Halo Results: A predator-prey model for ring dynamics produces transient structures like `straw' that can explain the halo morphology and spectroscopy: Cyclic velocity changes cause perturbed regions to reach higher collision speeds at some orbital phases, which preferentially removes small regolith particles; surrounding particles diffuse back too slowly to erase the effect: this gives the halo morphology; this requires energetic collisions (v ≈ 10m/sec, with throw distances about 200km, implying objects of scale R ≈ 20km).Transform to Duffing Eqn : With the coordinate transformation, z = M2/3, the Predator-Prey equations can be combined to form a single second-order differential equation with harmonic resonance forcing.Ring dynamics and history implications: Moon-triggered clumping explains both small and large particles at resonances. We calculate the stationary size distribution using a cell-to-cell mapping procedure that converts the phase-plane trajectories to a Markov chain. Approximating it as an asymmetric random walk with reflecting boundaries determines the power law index, using results of numerical simulations in the tidal environment. Aggregates can explain many dynamic aspects of the rings and can renew rings by shielding and recycling the material within them, depending on how long the mass is sequestered. We can ask: Are Saturn's rings a chaotic non-linear driven system?

A Self-Consistent Model of the Interacting Ring Current Ions and Electromagnetic Ion Cyclotron Waves, Initial Results: Waves and Precipitating Fluxes

NASA Technical Reports Server (NTRS)

Khazanov, G. V.; Gamayunov, K. V.; Jordanova, V. K.; Krivorutsky, E. N.

2002-01-01

Initial results from a newly developed model of the interacting ring current ions and ion cyclotron waves are presented. The model is based on the system of two kinetic equations: one equation describes the ring current ion dynamics, and another equation describes wave evolution. The system gives a self-consistent description of the ring current ions and ion cyclotron waves in a quasilinear approach. These equations for the ion phase space distribution function and for the wave power spectral density were solved on aglobal magnetospheric scale undernonsteady state conditions during the 2-5 May 1998 storm. The structure and dynamics of the ring current proton precipitating flux regions and the ion cyclotron wave-active zones during extreme geomagnetic disturbances on 4 May 1998 are presented and discussed in detail.

A Self-Consistent Model of the Interacting Ring Current Ions and Electromagnetic ICWs. Initial Results: Waves and Precipitation Fluxes

NASA Technical Reports Server (NTRS)

Khazanov, G. V.; Gamayunov, K. V.; Jordanova, V. K.; Krivorutsky, E. N.; Whitaker, Ann F. (Technical Monitor)

2001-01-01

Initial results from the new developed model of the interacting ring current ions and ion cyclotron waves are presented. The model described by the system of two bound kinetic equations: one equation describes the ring current ion dynamics, and another one gives wave evolution. Such system gives a self-consistent description of the ring current ions and ion cyclotron waves in a quasilinear approach. Calculating ion-wave relationships, on a global scale under non steady-state conditions during May 2-5, 1998 storm, we presented the data at three time cuts around initial, main, and late recovery phases of May 4, 1998 storm phase. The structure and dynamics of the ring current proton precipitating flux regions and the wave active ones are discussed in detail.

Jupiter's Main Ring/Ring Halo

NASA Technical Reports Server (NTRS)

1997-01-01

A mosaic of four images taken through the clear filter (610 nanometers) of the solid state imaging (CCD) system aboard NASA's Galileo spacecraft on November 8, 1996, at a resolution of approximately 46 kilometers (28.5 miles) per picture element (pixel) along Jupiter's rings. Because the spacecraft was only about 0.5 degrees above the ring plane, the image is highly foreshortened in the vertical direction. The images were obtained when Galileo was in Jupiter's shadow, peering back toward the Sun; the ring was approximately 2.3 million kilometers (1.4 million miles) away. The arc on the far right of the image is produced when sunlight is scattered by small particles comprising Jupiter's upper atmospheric haze. The ring also efficiently scatters light, indicating that much of its brightness is due to particles that are microns or less in diameter. Such small particles are believed to have human-scale lifetimes, i.e., very brief compared to the solar system's age.

Jupiter's ring system is composed of three parts - - a flat main ring, a lenticular halo interior to the main ring, and the gossamer ring, outside the main ring. The near and far arms of Jupiter's main ring extend horizontally across the mosaic, joining together at the ring's ansa, on the figure's far left side. The near arm of the ring appears to be abruptly truncated close to the planet, at the point where it passes into Jupiter's shadow. Some radial structure is barely visible across the ring's ansa (top image). A faint mist of particles can be seen above and below the main rings. This vertically extended 'halo' is unusual in planetary rings, and is probably caused by electromagnetic forces pushing the smallest grains out of the ring plane. Because of shadowing, the halo is not visible close to Jupiter in the lower right part of the mosaic. To accentuate faint features in the bottom image of the ring halo, different brightnesses are shown through color. Brightest features are white or yellow and the faintest are purple.

Jupiter's main ring is a thin strand of material encircling the planet. The diffuse innermost boundary begins at approximately 123,000 kilometers (76,429 miles). The main ring's outer radius is found to be at 128,940 kilometers (80,119 miles) +/-50 kilometers (31 miles), slightly less than the Voyager value of 129,130 kilometers (80,237 miles) +/-100 kilometers (62 miles), but very close to the orbit of the satellite Adrastea (128,980 kilometers or 80,144 miles). The main ring exhibits a marked drop in brightness at 127,849 kilometers (79,441 miles) +/-50 kilometers (31 miles), lying almost atop the orbit of the Jovian moon Metis at 127,978 kilometers (79,521 miles). Satellites seem to affect the structure of even tenuous rings like those found at Jupiter.

The Jet Propulsion Laboratory, Pasadena, CA manages the Galileo mission for NASA's Office of Space Science, Washington, DC. JPL is an operating division of California Institute of Technology (Caltech).

This image and other images and data received from Galileo are posted on the World Wide Web, on the Galileo mission home page at URL http://galileo.jpl.nasa.gov. Background information and educational context for the images can be found at URL http://www.jpl.nasa.gov/galileo/sepo

Compounds for neutron radiation detectors and systems thereof

DOEpatents

Payne, Stephen A; Stoeffl, Wolfgang; Zaitseva, Natalia P; Cherepy, Nerine J; Carman, M. Leslie

2014-05-27

A material according to one embodiment exhibits an optical response signature for neutrons that is different than an optical response signature for gamma rays, said material exhibiting performance comparable to or superior to stilbene in terms of distinguishing neutrons from gamma rays, wherein the material is not stilbene, the material comprising a molecule selected from a group consisting of: two or more benzene rings, one or more benzene rings with a carboxylic acid group, one or more benzene rings with at least one double bound adjacent to said benzene ring, and one or more benzene rings for which at least one atom in the benzene ring is not carbon.

Best Practices for Fuel System Contamination Detection and Remediation

DTIC Science & Technology

2015-12-14

Valve Fyre Ring GR DBB Style Plug Valve Gasket SS graphite Spiral DBB Style Plug Valve O- rings & slip seals VI DBB Style Plug Valve Packing gland...Pumps Impeller Key SS Vertical Turbine Pumps Impeller Retaining Ring SS Vertical Turbine Pumps Impellers (Electroless Nickel Plating) DI Vertical... Turbine Pumps Line Shaft SS Vertical Turbine Pumps Lineshaft Bearing CA Vertical Turbine Pumps Mating Ring Si-C Vertical Turbine Pumps Mechanical

Best Practices for Fuel System Contamination Detection and Remediation

DTIC Science & Technology

2016-01-15

Valve Fyre Ring GR DBB Style Plug Valve Gasket SS graphite Spiral DBB Style Plug Valve O- rings & slip seals VI DBB Style Plug Valve Packing gland...Pumps Impeller Key SS Vertical Turbine Pumps Impeller Retaining Ring SS Vertical Turbine Pumps Impellers (Electroless Nickel Plating) DI Vertical... Turbine Pumps Line Shaft SS Vertical Turbine Pumps Lineshaft Bearing CA Vertical Turbine Pumps Mating Ring Si-C Vertical Turbine Pumps Mechanical

The structure of Jupiter’s main ring from New Horizons: A comparison with other ring-moon systems

NASA Astrophysics Data System (ADS)

Chancia, Robert; Hedman, Matthew

2018-04-01

During New Horizon’s Jupiter flyby in 2007, the Long-Range Reconnaissance Imager (LORRI) took several images of the planet’s main ring. The data set contains two extended image-movies of the main ring, along with several brief observations at varying ring azimuths, and a small set of high phase angle images. Thus far, the only published work on the New Horizons Jupiter rings data set found seven bright clumps with sub-km equivalent radii embedded in the main ring (Showalter et al. 2007 Science). In this work, we searched the inner region of the main ring for any structures that might be perturbed at the 3:2 resonances with the rotation of Jupiter’s magnetic field or massive storms. We also examined the structure of the outer main ring in order to assess how it is shaped by the small moons Metis and Adrastea. Some of the features seen in Jupiter’s main ring are similar to those found in other dusty rings around Saturn, Uranus, and Neptune. By comparing these different rings, we can gain a better understanding of how small moons sculpt tenuous rings.

REQUIREMENTS AND GUIDELINES FOR NSLS EXPERIMENTAL BEAM LINE VACUUM SYSTEMS-REVISION B.

DOE Office of Scientific and Technical Information (OSTI.GOV)

FOERSTER,C.

Typical beam lines are comprised of an assembly of vacuum valves and shutters referred to as a ''front end'', optical elements to monochromatize, focus and split the photon beam, and an experimental area where a target sample is placed into the photon beam and data from the interaction is detected and recorded. Windows are used to separate sections of beam lines that are not compatible with storage ring ultra high vacuum. Some experimental beam lines share a common vacuum with storage rings. Sections of beam lines are only allowed to vent up to atmospheric pressure using pure nitrogen gas aftermore » a vacuum barrier is established to protect ring vacuum. The front end may only be bled up when there is no current in the machine. This is especially true on the VUV storage ring where for most experiments, windows are not used. For the shorter wavelength, more energetic photons of the x-ray ring, beryllium windows are used at various beam line locations so that the monochromator, mirror box or sample chamber may be used in a helium atmosphere or rough vacuum. The window separates ring vacuum from the environment of the downstream beam line components. The stored beam lifetime in the storage rings and the maintenance of desirable reflection properties of optical surfaces depend upon hydrocarbon-free, ultra-high vacuum systems. Storage ring vacuum systems will operate at pressures of {approximately} 1 x 10{sup {minus}10} Torr without beam and {approximately} 1 x 10{sup {minus}9} Torr with beam. Systems are free of hydrocarbons in the sense that no pumps, valves, etc. containing organics are used. Components are all-metal, chemically cleaned and bakeable. To the extent that beam lines share a common vacuum with the storage ring, the same criteria will hold for beam line components. The design philosophy for NSLS beam lines is to use all-metal, hydrocarbon-free front end components and recommend that experimenters use this approach for common vacuum hardware downstream of front ends. O-ring-sealed valves, if used, are not permitted upstream of the monochromator exit aperture. It will be the responsibility of users to demonstrate that their experiment will not degrade the pressure or quality of the storage ring vacuum. As a matter of operating policy, all beam lines will be monitored for prescribed pressure and the contribution of high mass gases to this pressure each time a beam line has been opened to ring vacuum.« less

Quantifying the relative contribution of climate and human impacts on streamflow at seasonal scale

NASA Astrophysics Data System (ADS)

Xin, Z.; Zhang, L.; Li, Y.; Zhang, C.

2017-12-01

Both climate change and human activities have induced changes to hydrology. The quantification of their impacts on streamflow is a challenge, especially at the seasonal scale due to seasonality of climate and human impacts, i.e., water use for irrigation and water storage and release due to reservoir operation. In this study, the decomposition method based on the Budyko hypothesis is extended to the seasonal scale and is used to quantify the climate and human impacts on annual and seasonal streamflow changes. The results are further compared and verified with those simulated by the hydrological method of abcd model. Data are split into two periods (1953-1974 and 1975-2005) to quantify the change. Three seasons, including wet, dry and irrigation seasons are defined by introducing the monthly aridity index. In general, results showed a satisfactory agreement between the Budyko decomposition method and abcd model. Both climate change and human activities were found to induce a decrease in streamflow at the annual scale, with 67% of the change contributed by human activities. At the seasonal scale, the human-induced contribution to the reduced stream flow was 64% and 73% for dry and wet seasons, respectively; whereas in the irrigation season, the impact of human activities on reducing the streamflow was more pronounced (180%) since the climate contributes to increased streamflow. In addition, the quantification results were analyzed for each month in the wet season to reveal the effects of intense precipitation and reservoir operation rules during flood season.

Clinical risk factors predicting genital fungal infections with sodium-glucose cotransporter 2 inhibitor treatment: The ABCD nationwide dapagliflozin audit.

PubMed

Thong, Ken Yan; Yadagiri, Mahender; Barnes, Dennis Joseph; Morris, David Stuart; Chowdhury, Tahseen Ahmad; Chuah, Ling Ling; Robinson, Anthony Michael; Bain, Stephen Charles; Adamson, Karen Ann; Ryder, Robert Elford John

2018-02-01

Treatment of type 2 diabetes with sodium-glucose cotransporter 2 (SGLT2) inhibitors may result in genital fungal infections. We investigated possible risk factors for developing such infections among patients treated with the SGLT2 inhibitor dapagliflozin. The Association of British Clinical Diabetologists (ABCD) collected data on patients treated with dapagliflozin in routine clinical practice from 59 diabetes centres. We assessed possible associations of patient's age, diabetes duration, body mass index, glycated haemoglobin, renal function, patient sex, ethnicity and prior genital fungal infection, urinary tract infection, urinary incontinence or nocturia, with the occurrence of ≥1 genital fungal infection within 26 weeks of treatment. 1049 out of 1116 patients (476 women, 573 men) were analysed. Baseline characteristics were, mean±SD, age 56.7±10.2years, BMI 35.5±6.9kg/m 2 and HbA 1c 9.4±1.5%. Only patient sex (13.2% women vs 3.3% men) and prior history of genital fungal infection (21.6% vs 7.3%) were found to be associated with occurrence of genital fungal infections after dapagliflozin treatment, adjusted OR 4.22 [95%CI 2.48,7.19], P<0.001 and adjusted OR 2.41 [95% CI 1.04,5.57], P=0.039, respectively. Women and patients with previous genital fungal infections had higher risks of developing genital fungal infections with dapagliflozin treatment. Copyright © 2017 Primary Care Diabetes Europe. All rights reserved.

Two programs designed to support condom use.

PubMed

1999-04-01

Two programs that were described during the 1999 National Symposium on Overcoming Barriers to Condom Use have been successful in making condoms an accepted norm in their communities. In the first, condom use among Northern Illinois University (NIU) students has risen from 30% in 1989 to 61% by 1997, while rates of STD infection have fallen by 50%. Program coordinators think the success is due to a combined effort to increase condom availability and make condom use a social norm. Condom use is promoted in advertisements in the student newspaper proclaiming that typical NIU students use condoms for protection from sexually transmitted diseases (STDs). Condoms are not distributed on the campus but are made available at several locations on a free-choice basis along with printed health education material. During a 1996 campus survey, a significant positive correlation was found between students' perception of the condom use of other students and their own condom use. In the second program, ABCD Health Service in Boston distributes condoms at no charge through hair salons serving Hispanic women, barber shops, and auto body shops. The program currently distributes more than 11,000 condoms in this manner each month. ABCD health educators also make presentations in beauty salons and to community groups. They are now using state funds to train community women to host "Safety Net" home-based informational parties, where participants play games that convey safer sex messages and receive condoms as party favors.

PARTICLE ACCELERATOR DIVISION SUMMARY REPORT FOR NOVEMBER 1958 THROUGH MAY 1959

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

Work in the division is summarized in the areas of theoretical studies, model magnet studies, ring magnet vacuum chamber, vacuum pumping system, ring magnet power supply, radio-frequency system, injection system, theoretical studies on radial motion through the linac, outgassing, and ferrite bonding. (For preceding period see ANL-5956.) (W.D.M.)

Performance of a shaft seal system for the LE-7 rocket engine oxidizer turbopump

NASA Astrophysics Data System (ADS)

Oike, Mamoru; Nosaka, Masataka; Kikuchi, Masataka; Watanabe, Yoshiaki

An experimental study on a rotating-shaft seal system for a high-pressure liquid oxygen (LOX) turbopump has been conducted to develop the LE-7 engine for the Japanese H-II launch vehicle. The LOX turbopump rotating-shaft seal system, which prevents LOX (4.9 MPa) and the high-pressure turbine-drive gas (16.6 MPa, 970 K) from mixing during high-speed operations (18,000 to 20,000 rpm), consists of the following seals: an LOX seal comprising a floating-ring and a wear-ring, a turbine gas seal comprising two floating-rings, and a helium purge seal comprising two segmented circumferential seal-rings. This report describes experimental and observational results concerning the rotating-shaft seal system obtained in the LOX turbopump operations and the seal tests. Based on comparisons between the measurements and the analytical results, sealing characteristics of the seal system are discussed. Inspections of the sealing surfaces after the engine firing tests demonstrated that the LOX turbopump rotating-shaft seal system has sufficient durability for use in the LE-7 engine for the H-II launch vehicle.

Edge-on!

NASA Astrophysics Data System (ADS)

2007-08-01

Peering at Uranus's Rings as they Swing Edge-on to Earth for the First Time Since their Discovery in 1977 As Uranus coasts through a brief window of time when its rings are edge-on to Earth - a view of the planet we get only once every 42 years - astronomers peering at the rings with ESO's Very Large Telescope and other space or ground-based telescopes are getting an unprecedented view of the fine dust in the system, free from the glare of the bright rocky rings. They may even find a new moon or two. ESO PR Photo 37/07 ESO PR Photo 37/07 The Uranus System "ESO's VLT took data at the precise moment when the rings were edge-on to Earth," said Imke de Pater, of University of California, Berkeley who coordinated the worldwide campaign. She worked with two team members observing in Chile: Daphne Stam of the Technical University Delft in the Netherlands and Markus Hartung of ESO. The observations were done with NACO, one of the adaptive optics instruments installed at the VLT. With adaptive optics, it is possible to obtain images almost free from the blurring effect of the atmosphere. It is as if the 8.2-m telescope were observing from space. Observations were also done with the Keck telescope in Hawaii, the Hubble Space Telescope, and at the Palomar Observatory. "Using different telescopes around the world allows us to observe as much of the changes during the ring-plane crossing as possible: when Uranus sets as seen from the VLT, it can still be observed by the Keck," emphasised Stam. Uranus orbits the Sun in 84 years. Twice during a Uranian year, the rings appear edge-on to Earth for a brief period. The rings were discovered in 1977, so this is the first time for a Uranus ring-crossing to be observed from Earth. The advantage of observations at a ring-plane crossing is that it becomes possible to look at the rings from the shadowed or dark side. From that vantage point, the normally bright outer rings grow fainter because their centimetre- to metre-sized rocks obscure one another, while the dim inner rings get brighter as their material merges into a thin band along the line of sight. Two little satellites called Cordelia and Ophelia straddle the brightest ring, the 'Epsilon Ring', and keep it in place, but it has always been assumed there must be more of these satellites that are confining the 9 other narrow rings. Normally the satellites are lost in the glare of the rings, but during these events the unique orientation makes the bright rings essentially invisible. Thus the ring plane crossing gives astronomers a rare chance, just once every 42 years, to image these tiny satellites. Imke de Pater and colleagues made observations of the rings with the Keck II telescope on 28 May 2007. These observations are presented in an article appearing today (Thursday 23 August) in Science Express, the online edition of Science magazine. There, the astronomers report that the rings of micron-sized dust have changed significantly since the Voyager 2 spacecraft photographed the Uranus system 21 years ago. Imke de Pater will discuss these results and the new images during a talk today at the European Planetary Science Congress 2007 meeting in Potsdam, Germany. An image of Uranus with the rings clearly visible was taken with ISAAC on ESO's VLT in 2002. It is available in ESO Press Photo 31/02.

Crystal structure of 3-amino-1-(4-meth-oxy-phen-yl)-1H-benzo[f]chromene-2-carbo-nitrile.

PubMed

Mohamed, Shaaban K; Horton, Peter N; Akkurt, Mehmet; Younes, Sabry H H; Albayati, Mustafa R

2015-07-01

In the title compound, C21H16N2O2, the meth-oxy-benzene ring is almost perpendicular to the mean plane of the naphthalene ring system, making a dihedral angle of 83.62 (5)°. The 4H-pyran ring fused with the naphthalene ring system is almost planar [maximum deviation = 0.033 (1) Å]. In the crystal, mol-ecules are linked into inversion dimers by pairs of N-H⋯N hydrogen bonds. N-H⋯O hydrogen bonds connect the dimers, forming a helical supra-molecular chain along the a-axis direction. The crystal packing also features C-H⋯π inter-actions.

Geometric and potential dynamics interpretation of the optic ring resonator bistability

NASA Astrophysics Data System (ADS)

Chiangga, S.; Chittha, T.; Frank, T. D.

2015-07-01

The optical bistability is a fundamental nonlinear feature of the ring resonator. A geometric and potential dynamics interpretation of the bistability is given. Accordingly, the bistability of the nonlinear system is shown to be a consequence of geometric laws of vector calculus describing the resonator ring. In contrast, the so-called transcendental relations that have been obtained in the literature in order to describe the optical wave are interpreted in terms of potential dynamical systems. The proposed novel interpretation provides new insights into the nature of the ring resonator optical bistability. The fundamental work by Rukhlenko, Premaratne and Agrawal (2010) as well as a more recent study by Chiangga, Pitakwongsaporn, Frank and Yupapin (2013) are considered.

A hydrological emulator for global applications - HE v1.0.0

NASA Astrophysics Data System (ADS)

Liu, Yaling; Hejazi, Mohamad; Li, Hongyi; Zhang, Xuesong; Leng, Guoyong

2018-03-01

While global hydrological models (GHMs) are very useful in exploring water resources and interactions between the Earth and human systems, their use often requires numerous model inputs, complex model calibration, and high computation costs. To overcome these challenges, we construct an efficient open-source and ready-to-use hydrological emulator (HE) that can mimic complex GHMs at a range of spatial scales (e.g., basin, region, globe). More specifically, we construct both a lumped and a distributed scheme of the HE based on the monthly abcd model to explore the tradeoff between computational cost and model fidelity. Model predictability and computational efficiency are evaluated in simulating global runoff from 1971 to 2010 with both the lumped and distributed schemes. The results are compared against the runoff product from the widely used Variable Infiltration Capacity (VIC) model. Our evaluation indicates that the lumped and distributed schemes present comparable results regarding annual total quantity, spatial pattern, and temporal variation of the major water fluxes (e.g., total runoff, evapotranspiration) across the global 235 basins (e.g., correlation coefficient r between the annual total runoff from either of these two schemes and the VIC is > 0.96), except for several cold (e.g., Arctic, interior Tibet), dry (e.g., North Africa) and mountainous (e.g., Argentina) regions. Compared against the monthly total runoff product from the VIC (aggregated from daily runoff), the global mean Kling-Gupta efficiencies are 0.75 and 0.79 for the lumped and distributed schemes, respectively, with the distributed scheme better capturing spatial heterogeneity. Notably, the computation efficiency of the lumped scheme is 2 orders of magnitude higher than the distributed one and 7 orders more efficient than the VIC model. A case study of uncertainty analysis for the world's 16 basins with top annual streamflow is conducted using 100 000 model simulations, and it demonstrates the lumped scheme's extraordinary advantage in computational efficiency. Our results suggest that the revised lumped abcd model can serve as an efficient and reasonable HE for complex GHMs and is suitable for broad practical use, and the distributed scheme is also an efficient alternative if spatial heterogeneity is of more interest.

Rotor balance system

NASA Technical Reports Server (NTRS)

Novotny, Rudolph J. (Inventor)

1989-01-01

A balance ring (18) which is shrunk fit within each disk (12) of a rotor is selectively ground for detail balance. A plurality of openings (20) through the outer edge of the balance ring receive weights during the asssembly balance of the rotor. A snap ring (42) retains the weights within the openings.

Prototyping of an Open-Architecture CMG System

DTIC Science & Technology

2012-12-01

Digital Absolute Optical Encoder .....................................................63  5.  Slip Ring ...After [71]) ................64  Figure 43.  Dynapar absolute encoder (replacement for the original encoder) ..................65  Figure 44.  Slip ring ...location on gimbal assembly .............................................................65  Figure 45.  MOOG SRA-73683–18 slip ring (From [74

Concise copper-catalyzed synthesis of tricyclic biaryl ether-linked aza-heterocyclic ring systems.

PubMed

Mestichelli, Paola; Scott, Matthew J; Galloway, Warren R J D; Selwyn, Jamie; Parker, Jeremy S; Spring, David R

2013-11-01

A new method for the synthesis of tricyclic biaryl ether-linked ring systems incorporating seven-, eight-, and nine-membered ring amines is presented. In the presence of catalytic quantities of copper(I), readily accessible acyclic precursors undergo an intramolecular carbon-oxygen bond-forming reaction facilitated by a "templating" chelating nitrogen atom. The methodology displays a broad substrate scope, is practical, and generates rare and biologically interesting tricyclic heteroaromatic products that are difficult to access by other means.

Molecular structure, interatomic interactions and vibrational analysis of 1,4-diazabicyclo[3.2.1]octane parent ring system

NASA Astrophysics Data System (ADS)

Britvin, Sergey N.; Rumyantsev, Andrey M.; Zobnina, Anastasia E.; Padkina, Marina V.

2017-02-01

Molecular structure of 1,4-diazabicyclo[3.2.1]octane, a parent ring of TAN1251 family of alkaloids, is herein characterized for the first time in comparison with the structure of nortropane (8-azabicyclo[3.2.1]octane), the parent framework of tropane ring system. The methods of study involve X-ray structural analysis, DFT geometry optimizations with infrared frequency calculations followed by natural bond orbital (NBO) analysis, and vibrational analysis of infrared spectrum.

AFTER: Batch jobs on the Apollo ring

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hofstadler, P.

1987-07-01

This document describes AFTER, a system that allows users of an Apollo ring to submit batch jobs to run without leaving themselves logged in to the ring. Jobs may be submitted to run at a later time or on a different node. Results from the batch job are mailed to the user through some designated mail system. AFTER features an understandable user interface, good on line help, and site customization. This manual serves primarily as a user's guide to AFTER although administration and installation are covered for completeness.

Fracture of Colvin-Galloway-Future band in a patient with mitral valve annuloplasty.

PubMed

Bauer, S; Rosendahl, U; Pietrowski, D; Ennker, J

2006-08-01

Annuloplasty with various annuloplasty ring systems is a fundamental part of mitral valve repair and has been frequently performed since its introduction by Carpentier in 1969. Due to the different advantages or disadvantages of each system, some controversies exist regarding the best type of ring annuloplasty support. Here we describe, for the first time, the case of a female patient in which a fracture of a semi-rigid open annuloplasty ring occurred, leading to annular deformation and mitral regurgitation.

ARC-1989-A89-7015

NASA Image and Video Library

1989-08-21

Range : 4.8 million km. ( 3 million miles ) P-34648 This Voyager 2, sixty-one second exposure, shot through clear filters, of Neptunes rings. The Voyager cameras were programmed to make a systematic search of the entire ring system for new material. The previously ring arc is visible as a long bright streak at the bottom of the image. Extening beyond the bright arc is a much fainter component which follows the arc in its orbit. this faint material was also visible leading the ring arc and, in total, covers at least half of the orbit before it becomes too faint to identify. Also visible in this image, is a continuous ring of faint material previously identified as a possible ring arc by Voyager. this continuous ring is located just outside the orbit of the moon 1989N3, which was also discovered by Voyager. This moon is visible as a streak in the lower left. the smear of 1989N3 is due to its own orbital motion during the exposure. Extreme computer processing of this image was made to enhance the extremely faint features of Neptunes moon system. the dark area surrounding the moon as well as the bright corners are due to this special processing.

Functional, Anatomical, and Molecular Investigation of the Cardiac Conduction System and Arrhythmogenic Atrioventricular Ring Tissue in the Rat Heart

PubMed Central

Atkinson, Andrew J.; Logantha, Sunil Jit R. J.; Hao, Guoliang; Yanni, Joseph; Fedorenko, Olga; Sinha, Aditi; Gilbert, Stephen H.; Benson, Alan P.; Buckley, David L.; Anderson, Robert H.; Boyett, Mark R.; Dobrzynski, Halina

2013-01-01

Background The cardiac conduction system consists of the sinus node, nodal extensions, atrioventricular (AV) node, penetrating bundle, bundle branches, and Purkinje fibers. Node‐like AV ring tissue also exists at the AV junctions, and the right and left rings unite at the retroaortic node. The study aims were to (1) construct a 3‐dimensional anatomical model of the AV rings and retroaortic node, (2) map electrical activation in the right ring and study its action potential characteristics, and (3) examine gene expression in the right ring and retroaortic node. Methods and Results Three‐dimensional reconstruction (based on magnetic resonance imaging, histology, and immunohistochemistry) showed the extent and organization of the specialized tissues (eg, how the AV rings form the right and left nodal extensions into the AV node). Multiextracellular electrode array and microelectrode mapping of isolated right ring preparations revealed robust spontaneous activity with characteristic diastolic depolarization. Using laser microdissection gene expression measured at the mRNA level (using quantitative PCR) and protein level (using immunohistochemistry and Western blotting) showed that the right ring and retroaortic node, like the sinus node and AV node but, unlike ventricular muscle, had statistically significant higher expression of key transcription factors (including Tbx3, Msx2, and Id2) and ion channels (including HCN4, Cav3.1, Cav3.2, Kv1.5, SK1, Kir3.1, and Kir3.4) and lower expression of other key ion channels (Nav1.5 and Kir2.1). Conclusions The AV rings and retroaortic node possess gene expression profiles similar to that of the AV node. Ion channel expression and electrophysiological recordings show the AV rings could act as ectopic pacemakers and a source of atrial tachycardia. PMID:24356527

Crisis management during anaesthesia: hypotension.

PubMed

Morris, R W; Watterson, L M; Westhorpe, R N; Webb, R K

2005-06-01

Hypotension is commonly encountered in association with anaesthesia and surgery. Uncorrected and sustained it puts the brain, heart, kidneys, and the fetus in pregnancy at risk of permanent or even fatal damage. Its recognition and correction is time critical, especially in patients with pre-existing disease that compromises organ perfusion. To examine the role of a previously described core algorithm "COVER ABCD-A SWIFT CHECK", supplemented by a specific sub-algorithm for hypotension, in the management of hypotension when it occurs in association with anaesthesia. Reports of hypotension during anaesthesia were extracted and studied from the first 4000 incidents reported to the Australian Incident Monitoring Study (AIMS). The potential performance of the COVER ABCD algorithm and the sub-algorithm for hypotension was compared with the actual management as reported by the anaesthetist involved. There were 438 reports that mentioned hypotension, cardiovascular collapse, or cardiac arrest. In 17% of reports more than one cause was attributed and 550 causative events were identified overall. The most common causes identified were drugs (26%), regional anaesthesia (14%), and hypovolaemia (9%). Concomitant changes were reported in heart rate or rhythm in 39% and oxygen saturation or ventilation in 21% of reports. Cardiac arrest was documented in 25% of reports. As hypotension was frequently associated with abnormalities of other vital signs, it could not always be adequately addressed by a single algorithm. The sub-algorithm for hypotension is adequate when hypotension occurs in association with sinus tachycardia. However, when it occurs in association with bradycardia, non-sinus tachycardia, desaturation or signs of anaphylaxis or other problems, the sub-algorithm for hypotension recommends cross referencing to other relevant sub-algorithms. It was considered that, correctly applied, the core algorithm COVER ABCD would have diagnosed 18% of cases and led to resolution in two thirds of these. It was further estimated that completion of this followed by the specific sub-algorithm for hypotension would have led to earlier recognition of the problem and/or better management in 6% of cases compared with actual management reported. Pattern recognition in most cases enables anaesthetists to determine the cause and manage hypotension. However, an algorithm based approach is likely to improve the management of a small proportion of atypical but potentially life threatening cases. While an algorithm based approach will facilitate crisis management, the frequency of co-existing abnormalities in other vital signs means that all cases of hypotension cannot be dealt with using a single algorithm. Diagnosis, in particular, may potentially be assisted by cross referencing to the specific sub-algorithms for these.

Simplification of a complex microbial antilisterial consortium to evaluate the contribution of its flora in uncooked pressed cheese.

PubMed

Callon, Cécile; Saubusse, Marjorie; Didienne, Robert; Buchin, Solange; Montel, Marie-Christine

2011-02-28

A complex microbial consortium derived from raw milk and composed of populations classified in 4 groups (lactic acid bacteria (A), Gram positive catalase positive bacteria (B), Gram negative bacteria (C) and yeasts (D)) can contribute to the inhibition of Listeria monocytogenes in the core of an uncooked pressed cheese. To identify what groups may be involved in the inhibition, the consortium was simplified by successively omitting one group at a time. Pasteurized milk was inoculated with these more or less complex consortia and their effects on L. monocytogenes count, pH, acids and volatile compounds in the core of uncooked pressed cheese were evaluated. The growth of L. monocytogenes was the highest in cheeses prepared with pasteurized milk and only St. thermophilus. Inhibition in other cheeses was expressed by comparison with growth in these ones. All the consortia containing both lactic acid bacteria (group A) and Gram positive catalase positive bacteria (group B)--ABCD, ABD, ABC, AB--were more inhibitory than those containing lactic acid bacteria on its own (A) or associated only with yeasts (AD) or/and Gram negative (ADC). Consortia without lactic acid bacteria were weakly inhibitory or had no effect. Gram positive catalase positive bacteria alone were not inhibitory although most of the species became established in the cheeses. The Lactobacillus population (Lb. casei, Lb. plantarum, Lb. curvatus and Lb. farciminis) was predominant in cheeses (9 log CFU/g) with a higher count than Leuconostoc (7 log CFU/g) and Enterococcus (7 log CFU/g). Lactobacillus counts were negatively correlated with those of L. monocytogenes (r=-0.84 at 18 days) and with the level of D-lactic acid. There was no correlation between L. monocytogenes and Leuconostoc or Enterococcus counts. Complex consortium ABCD and AB not only had a stronger inhibitory power in cheeses than consortium AD, they were also associated with the highest levels of L-lactic and acetic acids. All cheeses inoculated with lactic acid bacteria differed from those without by higher levels of ethyl formiate, pentane and alcohols (2-butanol, 2-pentanol), and lower levels of ketones (2-hexanone, 2,3-butanedione) and aldehydes (2-methyl-butanal). Levels of 2-methyl-butanal, 2-butanol and 2-pentanol were higher in ABCD and AB cheeses than in AD cheeses. Beside their contribution to the inhibition, their effect on cheese flavour must be evaluated. Published by Elsevier B.V.

Water impact test of aft skirt end ring, and mid ring segments of the Space Shuttle Solid Rocket Booster

NASA Technical Reports Server (NTRS)

1983-01-01

The results of water impact loads tests using aft skirt end ring, and mid ring segments of the Space Shuttle Solid Rocket Booster (SRB) are examined. Dynamic structural response data is developed and an evaluation of the model in various configurations is presented. Impact velocities are determined for the SRB with the larger main chute system. Various failure modes are also investigated.

Dusty plasma (Yukawa) rings

NASA Astrophysics Data System (ADS)

Sheridan, T. E.; Gallagher, James C.

2016-11-01

One-dimensional and quasi-one-dimensional strongly coupled dusty plasma rings have been created experimentally. Longitudinal (acoustic) and transverse (optical) dispersion relations for the one-ring are measured and found to be in excellent agreement with the theory for an unbounded straight chain of particles interacting through a Yukawa (i.e., screened Coulomb or Debye-Hückel) potential. These rings provide a new experimental system to directly study one-dimensional and quasi-one-dimensional linear and nonlinear phenomena.

Mechanical capacitor

NASA Technical Reports Server (NTRS)

Kirk, J. A.; Studer, P. A.; Evans, H. E.

1976-01-01

A new energy storage system (the mechanical capacitor), using a spokeless magnetically levitated composite ring rotor, is described and design formulas for sizing the components are presented. This new system is configured around a permanent magnet (flux biased) suspension which has active servo control in the radial direction and passive control in the axial direction. The storage ring is used as a moving rotor and electronic commutation of the stationary armature coils is proposed. There is no mechanical contact with the rotating spokeless ring; therefore, long life and near zero rundown losses are projected. A 7-kW h system is sized to demonstrate feasibility. A literature review of flywheel energy storage systems is also presented and general formulas are developed for comparing rotor geometries.

Damping the e-p instability in the SNS accumulator ring

NASA Astrophysics Data System (ADS)

Evans, N. J.; Deibele, C.; Aleksandrov, A.; Xie, Z.

2018-03-01

A broadband, digital damper system for both transverse planes developed for the SNS accumulator ring has recently damped the first indications of the broadband 50-150 MHz e-p instability in a 1.2 MW neutron production beam. This paper presents details of the design and operation of the SNS damper system as well as results of active damping of the e-p instability in the SNS ring showing a reduction in power of betatron oscillation over the 10-300 MHz band of up to 70%. The spectral content of the beam during operation, with and without the damper system is presented and performance of the damper system is evaluated.

The stability of the oscillation motion of charged grains in the Saturnian ring system

NASA Astrophysics Data System (ADS)

Xu, R.-L.; Houpis, L. F.

1985-02-01

A perturbation approach for the gravitoelectrodynamic forces encountered in the corotating plasma environment of Saturn is used to determine the stability of charged grains, given a random initial velocity. Attention is given to the implications of the Northrop and Hill (1982) and Mendis et al. (1982) results for the formation of the Saturnian ring system, and it is suggested that the marginal z stability radius at 1.5245 Saturn radii for Kepler-launched particles is due to an erosion process with ejecta of the order 0.05-0.5 microns, rather than that of the previously suggested plasma. The diffuseness of the Saturnian rings beyond the F ring is also explained in terms of instability, while a new critical radius for r instability is suggestd for the optical depth feature at 1.72 Saturn radii. The F ring is analyzed in detail.

Carbonatite ring-complexes explained by caldera-style volcanism

PubMed Central

Andersson, Magnus; Malehmir, Alireza; Troll, Valentin R.; Dehghannejad, Mahdieh; Juhlin, Christopher; Ask, Maria

2013-01-01

Carbonatites are rare, carbonate-rich magmatic rocks that make up a minute portion of the crust only, yet they are of great relevance for our understanding of crustal and mantle processes. Although they occur in all continents and from Archaean to present, the deeper plumbing system of carbonatite ring-complexes is usually poorly constrained. Here, we show that carbonatite ring-complexes can be explained by caldera-style volcanism. Our geophysical investigation of the Alnö carbonatite ring-complex in central Sweden identifies a solidified saucer-shaped magma chamber at ~3 km depth that links to surface exposures through a ring fault system. Caldera subsidence during final stages of activity caused carbonatite eruptions north of the main complex, providing the crucial element to connect plutonic and eruptive features of carbonatite magmatism. The way carbonatite magmas are stored, transported and erupt at the surface is thus comparable to known emplacement styles from silicic calderas. PMID:23591904

A Self-Consistent Model of the Interacting Ring Current Ions with Electromagnetic ICWs

NASA Technical Reports Server (NTRS)

Khazanov, G. V.; Gamayunov, K. V.; Jordanova, V. K.; Krivorutsky, E. N.; Whitaker, Ann F. (Technical Monitor)

2001-01-01

Initial results from a newly developed model of the interacting ring current ions and ion cyclotron waves are presented. The model is based on the system of two bound kinetic equations: one equation describes the ring current ion dynamics, and another equation describes wave evolution. The system gives a self-consistent description of ring current ions and ion cyclotron waves in a quasilinear approach. These two equations were solved on a global scale under non steady-state conditions during the May 2-5, 1998 storm. The structure and dynamics of the ring current proton precipitating flux regions and the wave active zones at three time cuts around initial, main, and late recovery phases of the May 4, 1998 storm phase are presented and discussed in detail. Comparisons of the model wave-ion data with the Polar/HYDRA and Polar/MFE instruments results are presented..

Carbonatite ring-complexes explained by caldera-style volcanism.

PubMed

Andersson, Magnus; Malehmir, Alireza; Troll, Valentin R; Dehghannejad, Mahdieh; Juhlin, Christopher; Ask, Maria

2013-01-01

Carbonatites are rare, carbonate-rich magmatic rocks that make up a minute portion of the crust only, yet they are of great relevance for our understanding of crustal and mantle processes. Although they occur in all continents and from Archaean to present, the deeper plumbing system of carbonatite ring-complexes is usually poorly constrained. Here, we show that carbonatite ring-complexes can be explained by caldera-style volcanism. Our geophysical investigation of the Alnö carbonatite ring-complex in central Sweden identifies a solidified saucer-shaped magma chamber at ~3 km depth that links to surface exposures through a ring fault system. Caldera subsidence during final stages of activity caused carbonatite eruptions north of the main complex, providing the crucial element to connect plutonic and eruptive features of carbonatite magmatism. The way carbonatite magmas are stored, transported and erupt at the surface is thus comparable to known emplacement styles from silicic calderas.

Structural dynamic and thermal stress analysis of nuclear reactor vessel support system

NASA Technical Reports Server (NTRS)

Chi-Diango, J.

1972-01-01

A nuclear reactor vessel is supported by a Z-ring and a box ring girder. The two proposed structural configurations to transmit the loads from the Z-ring and the box ring girder to the foundation are shown. The cantilever concrete ledge transmitting the load from the Z-ring and the box girder via the cavity wall to the foundation is shown, along with the loads being transmitted through one of the six steel columns. Both of these two supporting systems were analyzed by using rigid format 9 of NASTRAN for dynamic loads, and the thermal stresses were analyzed by AXISOL. The six column configuration was modeled by a combination of plate and bar elements, and the concrete cantilever ledge configuration was modeled by plate elements. Both configurations were found structurally satisfactory; however, nonstructural considerations favored the concrete cantilever ledge.

The orbits of the uranian satellites and rings, the gravity field of the uranian system, and the orientation of the pole of Uranus

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jacobson, R. A., E-mail: robert.jacobson@jpl.nasa.gov

2014-11-01

French et al. determined the orbits of the Uranian rings, the orientation of the pole of Uranus, and the gravity harmonics of Uranus from Earth-based and Voyager ring occultations. Jacobson et al. determined the orbits of the Uranian satellites and the masses of Uranus and its satellites from Earth-based astrometry and observations acquired with the Voyager 2 spacecraft; they used the gravity harmonics and pole from French et al. Jacobson and Rush reconstructed the Voyager 2 trajectory and redetermined the Uranian system gravity parameters, satellite orbits, and ring orbits in a combined analysis of the data used previously augmented withmore » additional Earth-based astrometry. Here we report on an extension of that work that incorporates additional astrometry and ring occultations together with improved data processing techniques.« less

Computer controlled performance mapping of thermionic converters: effect of collector, guard-ring potential imbalances on the observed collector current-density, voltage characteristics and limited range performance map of an etched-rhenium, niobium planar converter

NASA Technical Reports Server (NTRS)

Manista, E. J.

1972-01-01

The effect of collector, guard-ring potential imbalance on the observed collector-current-density J, collector-to-emitter voltage V characteristic was evaluated in a planar, fixed-space, guard-ringed thermionic converter. The J,V characteristic was swept in a period of 15 msec by a variable load. A computerized data acquisition system recorded test parameters. The results indicate minimal distortion of the J,V curve in the power output quadrant for the nominal guard-ring circuit configuration. Considerable distortion, along with a lowering of the ignited-mode striking voltage, was observed for the configuration with the emitter shorted to the guard ring. A limited-range performance map of an etched-rhenium, niobium, planar converter was obtained by using an improved computer program for the data acquisition system.

AnnoSys—implementation of a generic annotation system for schema-based data using the example of biodiversity collection data

PubMed Central

Kusber, W.-H.; Tschöpe, O.; Güntsch, A.; Berendsohn, W. G.

2017-01-01

Abstract Biological research collections holding billions of specimens world-wide provide the most important baseline information for systematic biodiversity research. Increasingly, specimen data records become available in virtual herbaria and data portals. The traditional (physical) annotation procedure fails here, so that an important pathway of research documentation and data quality control is broken. In order to create an online annotation system, we analysed, modeled and adapted traditional specimen annotation workflows. The AnnoSys system accesses collection data from either conventional web resources or the Biological Collection Access Service (BioCASe) and accepts XML-based data standards like ABCD or DarwinCore. It comprises a searchable annotation data repository, a user interface, and a subscription based message system. We describe the main components of AnnoSys and its current and planned interoperability with biodiversity data portals and networks. Details are given on the underlying architectural model, which implements the W3C OpenAnnotation model and allows the adaptation of AnnoSys to different problem domains. Advantages and disadvantages of different digital annotation and feedback approaches are discussed. For the biodiversity domain, AnnoSys proposes best practice procedures for digital annotations of complex records. Database URL: https://annosys.bgbm.fu-berlin.de/AnnoSys/AnnoSys PMID:28365735

Electronic Information Standards to Support Obesity Prevention and Bridge Services Across Systems, 2010-2015.

PubMed

Wiltz, Jennifer L; Blanck, Heidi M; Lee, Brian; Kocot, S Lawrence; Seeff, Laura; McGuire, Lisa C; Collins, Janet

2017-10-26

Electronic information technology standards facilitate high-quality, uniform collection of data for improved delivery and measurement of health care services. Electronic information standards also aid information exchange between secure systems that link health care and public health for better coordination of patient care and better-informed population health improvement activities. We developed international data standards for healthy weight that provide common definitions for electronic information technology. The standards capture healthy weight data on the "ABCDs" of a visit to a health care provider that addresses initial obesity prevention and care: assessment, behaviors, continuity, identify resources, and set goals. The process of creating healthy weight standards consisted of identifying needs and priorities, developing and harmonizing standards, testing the exchange of data messages, and demonstrating use-cases. Healthy weight products include 2 message standards, 5 use-cases, 31 LOINC (Logical Observation Identifiers Names and Codes) question codes, 7 healthy weight value sets, 15 public-private engagements with health information technology implementers, and 2 technical guides. A logic model and action steps outline activities toward better data capture, interoperable systems, and information use. Sharing experiences and leveraging this work in the context of broader priorities can inform the development of electronic information standards for similar core conditions and guide strategic activities in electronic systems.

Ultrasonic Resonance Spectroscopy of Composite Rings for Flywheel Rotors

NASA Technical Reports Server (NTRS)

Harmon, Laura M.; Baaklini, George Y.

2001-01-01

Flywheel energy storage devices comprising multilayered composite rotor systems are being studied extensively for utilization in the International Space Station. These composite material systems were investigated with a recently developed ultrasonic resonance spectroscopy technique. The system employs a swept frequency approach and performs a fast Fourier transform on the frequency spectrum of the response signal. In addition. the system allows for equalization of the frequency spectrum, providing all frequencies with equal amounts of energy to excite higher order resonant harmonics. Interpretation of the second fast Fourier transform, along with equalization of the frequency spectrum, offers greater assurance in acquiring and analyzing the fundamental frequency, or spectrum resonance spacing. The range of frequencies swept in a pitch-catch mode was varied up to 8 MHz, depending on the material and geometry of the component. Single and multilayered material samples, with and without known defects, were evaluated to determine how the constituents of a composite material system affect the resonant frequency. Amplitude and frequency changes in the spectrum and spectrum resonance spacing domains were examined from ultrasonic responses of a flat composite coupon, thin composite rings, and thick composite rings. Also, the ultrasonic spectroscopy responses from areas with an intentional delamination and a foreign material insert, similar to defects that may occur during manufacturing malfunctions, were compared with those from defect-free areas in thin composite rings. A thick composite ring with varying thickness was tested to investigate the full-thickness resonant frequency and any possible bulk interfacial bond issues. Finally, the effect on the frequency response of naturally occurring single and clustered voids in a composite ring was established.

Rings from Close Encounters

NASA Astrophysics Data System (ADS)

Kohler, Susanna

2016-09-01

Weve recently discovered narrow sets of rings around two minor planets orbiting in our solar system. How did these rings form? A new study shows that they could be a result of close encounters between the minor planets and giants like Jupiter or Neptune.Unexpected Ring SystemsPositions of the centaurs in our solar system (green). Giant planets (red), Jupiter trojans (grey), scattered disk objects (tan) and Kuiper belt objects (blue) are also shown. [WilyD]Centaurs are minor planets in our solar system that orbit between Jupiter and Neptune. These bodies of which there are roughly 44,000 with diameters larger than 1 km have dynamically unstable orbits that cross paths with those of one or more giant planets.Recent occultation observations of two centaurs, 10199 Chariklo and 2060 Chiron, revealed that these bodies both host narrow ring systems. Besides our four giant planets, Chariklo and Chiron are the only other bodies in the solar system known to have rings. But how did these rings form?Scientists have proposed several models, implicating collisions, disruption of a primordial satellite, or dusty outgassing. But a team of scientists led by Ryuki Hyodo (Paris Institute of Earth Physics, Kobe University) has recently proposed an alternative scenario: what if the rings were formed from partial disruption of the centaur itself, after it crossed just a little too close to a giant planet?Tidal Forces from a GiantHyodo and collaborators first used past studies of centaur orbits to estimate that roughly 10% of centaurs experience close encounters (passing within a distance of ~2x the planetary radius) with a giant planet during their million-year lifetime. The team then performed a series of simulations of close encounters between a giant planet and a differentiated centaur a body in which the rocky material has sunk to form a dense silicate core, surrounded by an icy mantle.Some snapshots of simulation outcomes (click for a closer look!) for different initial states of the centaur internal structure, its spin, and the distance of closest approach of the centaur to the giant planet. Blue and red represent icy and silicate material, respectively. [Hyodo et al. 2016]The outcomes of the close encounters are diverse, depending strongly on the internal structure and spin of the minor planet and the geometry of the encounter. But the team finds that, in many scenarios, the centaur is only partially destroyed by tidal forces from the giant as it passes close by.In these cases the icy mantle and even some of the centaurs core can be ripped away and scattered, becoming gravitationally bound to the largest remaining clump of the core. The particles travel in highly eccentric orbits, gradually damping as they collide with each other and forming a disk around the remaining core. Further dynamical evolution of this disk could easily shape the rings that we observe today around Chariklo and Chiron.If Hyodo and collaborators scenario is correct, then Chariklo and Chiron are differentiated bodies with dense silicate cores, and their rings are either pure water ice, or a mixture of water ice and a small amount of silicate. Future observations of these minor planets will help to test this model and observations of other centaurs may discover yet more ring systems hiding in our solar system!BonusCheck out this awesomeanimation from ESO showing an artists impression of thering system around Chariklo! [ESO/L. Calada/M. Kornmesser]CitationRyuki Hyodo et al 2016 ApJ 828 L8. doi:10.3847/2041-8205/828/1/L8

Mega-rings Surrounding Timber Mountain Nested Calderas, Geophysical Anomalies: Rethinking Structure and Volcanism Near Yucca Mountain (YM), Nevada

NASA Astrophysics Data System (ADS)

Tynan, M. C.; Smith, K. D.; Savino, J. M.; Vogt, T. J.

2004-12-01

Observed regional mega-rings define a zone ˜80-100 km in diameter centered on Timber Mountain (TM). The mega-rings encompass known smaller rhyolitic nested Miocene calderas ( ˜11-15 my, < 10 km circular to elliptical small "rings") and later stage basaltic features (< 11 my, small flows, cones, dikes) in the Southwest Nevada Volcanic Field. Miocene rhyolitic calderas cluster within the central area and on the outer margin of the interpreted larger mega-ring complex. The mega-ring interpretation is consistent with observations of regional physiography, tomographic images, seismicity patterns, and structural relationships. Mega-rings consist of arcuate faulted blocks with deformation (some remain active structures) patterns showing a genetic relationship to the TM volcanic system; they appear to be spatially associated and temporally correlated with Miocene volcanism and two geophysically identified crustal/upper mantle features. A 50+ km diameter pipe-like high velocity anomaly extends from crustal depth to over 200 km beneath TM (evidence for 400km depth to NE). The pipe is located between two ˜100 km sub-parallel N/S linear trends of small-magnitude earthquake activity, one extending through the central NV Test Site, and a second located near Beatty, NV. Neither the kinematics nor relational mechanism of 100km seismically active N/S linear zones, pipe, and mega-rings are understood. Interpreted mega-rings are: 1) Similar in size to larger terrestrial volcanic complexes (e.g., Yellowstone, Indonesia's Toba system); 2) Located in the region of structural transition from the Mohave block to the south, N/S Basin and Range features to the north, Walker Lane to the NW, and the Las Vegas Valley shear zone to the SE; 3) Associated with the two seismically active zones (similar to other caldera fault-bounded sags), the mantle high velocity feature, and possibly a regional bouguer gravity anomaly; 4) Nearly coincident with area hydrologic basins and sub-basins; 5) Similar to features described from terrestrial and planetary caldera-collapse studies, and as modeled in laboratory scaled investigations (ice melt, balloon/sand). Post Mid-Miocene basalts commonly occur within or adjacent to the older rhyolitic caldera moats; other basaltic material occurs marginal to both the outer rings of the interpreted mega-ring system and high velocity pipe. The YM repository may be situated in an isolated structural setting within the mega-ring system; basaltic materials are absent in the block for over 11my for geologic reasons. The mega-ring model may better explain YM area structures (Highway 95 fault), tectonism, and volcanism. Coincident physiographic, geologic, and geophysical features associated with the mega-rings feature, and temporal characteristics of regional seismicity and volcanism suggest the need to critically re-assess regional scale and YM tectonic, seismotectonic, and volcanic models.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Araujo, R. A. N.; Sfair, R.; Winter, O. C., E-mail: ran.araujo@gmail.com, E-mail: rsfair@feg.unesp.br, E-mail: ocwinter@gmail.com

The Centaur population is composed of minor bodies wandering between the giant planets that frequently perform close gravitational encounters with these planets, leading to a chaotic orbital evolution. Recently, the discovery of two well-defined narrow rings was announced around the Centaur 10199 Chariklo. The rings are assumed to be in the equatorial plane of Chariklo and to have circular orbits. The existence of a well-defined system of rings around a body in such a perturbed orbital region poses an interesting new problem. Are the rings of Chariklo stable when perturbed by close gravitational encounters with the giant planets? Our approachmore » to address this question consisted of forward and backward numerical simulations of 729 clones of Chariklo, with similar initial orbits, for a period of 100 Myr. We found, on average, that each clone experiences during its lifetime more than 150 close encounters with the giant planets within one Hill radius of the planet in question. We identified some extreme close encounters that were able to significantly disrupt or disturb the rings of Chariklo. About 3% of the clones lose their rings and about 4% of the clones have their rings significantly disturbed. Therefore, our results show that in most cases (more than 90%), the close encounters with the giant planets do not affect the stability of the rings in Chariklo-like systems. Thus, if there is an efficient mechanism that creates the rings, then these structures may be common among these kinds of Centaurs.« less

Memory characteristics of ring-shaped ceramic superconductors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Takeoka, A.; Hasunuma, M.; Sakaiya, S.

1989-03-01

For the practical application of ceramic superconductors, the authors investigated the residual magnetic field characteristics of ring-shaped ceramic superconductors in a Y-Ba-Cu-O system with high Tc. The residual magnetic field of a ring with asymmetric current paths, supplied by external currents, appeared when one of the branch currents was above the critical current. The residual magnetic field saturated when both brach currents exceeded the critical current of the ring and showed hysteresis-like characteristics. The saturated magnetic field is subject to the critical current of the ring. A superconducting ring with asymmetric current paths suggests a simple and quite new persistent-currentmore » type memory device.« less

Physical studies of the planetary rings

NASA Technical Reports Server (NTRS)

Ip, W.-H.

1980-01-01

In this review paper, the physical properties of the Saturnian and Uranian rings as derived from ground-based observations are first discussed. Focus is then shifted to the study of the orbital dynamics of the ring particles. Numerical simulations of the evolutionary history of a system of colliding particles in differential rotation together with theoretical modeling of the inelastic collision processes are surveyed. In anticipation of the information returned from in situ measurements by space probes, interactions of the planetary rings with the interplanetary meteoroids and planetary magnetospheres are briefly considered. Finally, models of planetary ring origin are examined. In this connection, some recent work on the satellite resonant perturbation effects on the ring structure are also touched upon.

Crystal structure of 5''-(4-chloro-benzyl-idene)-4'-(4-chloro-phen-yl)-1'-methyltri-spiro[acenapthylene-1,2'-pyrrolidine-3',1''-cyclo-hexane-3'',2'''-[1,3]dioxane]-2(1H),6''-dione.

PubMed

Chandralekha, Kuppan; Gavaskar, Deivasigamani; Sureshbabu, Adukamparai Rajukrishnan; Lakshmi, Srinivasakannan

2015-11-01

In the title compound, C36H29Cl2NO4, two spiro links connect the methyl-substituted pyrrolidine ring to the ace-naphthyl-ene and cyclo-hexa-none rings. The cyclo-hexa-none ring is further connected to the dioxalane ring by a third spiro junction. The five-membered ring of the ace-naphthylen-1-one ring system adopts a flattened envelope conformation, with the ketonic C atom as the flap, whereas the dioxalane and pyrrolidine rings each have a twist conformation. The cyclo-hexenone ring assumes a boat conformation. An intra-molecular C-H⋯O hydrogen-bond inter-action is present. In the crystal, mol-ecules are linked by non-classical C-H⋯O hydrogen bonds, forming chains extending parallel to the a axis.

Shaft balancing

DOEpatents

Irwin, John A.

1979-01-01

A gas turbine engine has an internal drive shaft including one end connected to a driven load and an opposite end connected to a turbine wheel and wherein the shaft has an in situ adjustable balance system near the critical center of a bearing span for the shaft including two 360.degree. rings piloted on the outer diameter of the shaft at a point accessible through an internal engine panel; each of the rings has a small amount of material removed from its periphery whereby both of the rings are precisely unbalanced an equivalent amount; the rings are locked circumferentially together by radial serrations thereon; numbered tangs on the outside diameter of each ring identify the circumferential location of unbalance once the rings are locked together; an aft ring of the pair of rings has a spline on its inside diameter that mates with a like spline on the shaft to lock the entire assembly together.

Beam position monitoring system at CESR

NASA Astrophysics Data System (ADS)

Billing, M. G.; Bergan, W. F.; Forster, M. J.; Meller, R. E.; Rendina, M. C.; Rider, N. T.; Sagan, D. C.; Shanks, J.; Sikora, J. P.; Stedinger, M. G.; Strohman, C. R.; Palmer, M. A.; Holtzapple, R. L.

2017-09-01

The Cornell Electron-positron Storage Ring (CESR) has been converted from a High Energy Physics electron-positron collider to operate as a dedicated synchrotron light source for the Cornell High Energy Synchrotron Source (CHESS) and to conduct accelerator physics research as a test accelerator, capable of studying topics relevant to future damping rings, colliders and light sources. Some of the specific topics that were targeted for the initial phase of operation of the storage ring in this mode, labeled CESRTA (CESR as a Test Accelerator), included 1) tuning techniques to produce low emittance beams, 2) the study of electron cloud development in a storage ring and 3) intra-beam scattering effects. The complete conversion of CESR to CESRTA occurred over a several year period and is described elsewhere. As a part of this conversion the CESR beam position monitoring (CBPM) system was completely upgraded to provide the needed instrumental capabilities for these studies. This paper describes the new CBPM system hardware, its function and representative measurements performed by the upgraded system.

1393 Ring Bus at JPL: Description and Status

NASA Technical Reports Server (NTRS)

Wysocky, Terry R.

2007-01-01

Completed Ring Bus IC V&V Phase - Ring Bus Test Plan Completed for SIM Project - Applicable to Other Projects Implemented a Avionics Bus Based upon the IEEE 1393 Standard - Excellent Starting Point for a General Purpose High-Speed Spacecraft Bus - Designed to Meet SIM Requirements for - Real-time deterministic, distributed systems. - Control system requirements - Fault detection and recovery Other JPL Projects Considering Implementation F'light Software Ring Bus Driver Module Began in 2006, Continues Participating in Standard Revision. Search for Earth-like planets orbiting nearby stars and measure the masses and orbits of the planets it finds. Survey 2000 nearby stars for planetary systems to learn whether our Solar System is unusual, or typical. Make a new catalog of star position 100 times more accurate than current measurements. Learn how our galaxy formed and will evolve by studying the dynamics of its stars. Critically test models of exactly how stars shine, including exotic objects like black holes, neutron stars and white dwarfs.

Accelerometer telemetry system

NASA Technical Reports Server (NTRS)

Konigsberg, E. (Inventor)

1976-01-01

An accelerometer telemetry system incorporated in a finger ring is used for monitoring the motor responses of a subject. The system includes an accelerometer, battery, and transmitter and provides information to a remote receiver regarding hand movements of a subject wearing the ring, without the constraints of wires. Possible applications include the detection of fatigue from the hand movements of the wearer.

Rings Research in the Next Decade

NASA Astrophysics Data System (ADS)

Burns, J. A.; Tiscareno, M. S.

2009-12-01

The study of planetary ring systems forms a key component of planetary science for several reasons: 1) The evolution and current states of planets and their satellites are affected in many ways by rings, while 2) conversely, properties of planets and moons and other solar system populations are revealed by their effects on rings; 3) highly structured and apparently delicate ring systems may be bellwethers, constraining various theories of the origin and evolution of their entire planetary system; and finally, 4) planetary rings provide an easily observable analogue to other astrophysical disk systems, enabling real “ground truth” results applicable to disks much more remote in space and/or time, including proto-planetary disks, circum-stellar disks, and even galaxies. Significant advances have been made in rings science in the past decade. The highest-priority rings research recommendations of the last Planetary Science Decadal Survey were to operate and extend the Cassini orbiter mission at Saturn; this has been done with tremendous success, accounting for much of the progress made on key science questions, as we will describe. Important progress in understanding the rings of Saturn and other planets has also come from Earth-based observational and theoretical work, again as prioritized by the last Decadal Survey. However, much important work remains to be done. At Saturn, the Cassini Solstice Mission must be brought to a successful completion. Priority should also be placed on sending spacecraft to Neptune and/or Uranus, now unvisited for more than 20 years. At Jupiter and Pluto, opportunities afforded by visiting spacecraft capable of studying rings should be exploited. On Earth, the need for continued research and analysis remains strong, including in-depth analysis of rings data already obtained, numerical and theoretical modeling work, laboratory analysis of materials and processes analogous to those found in the outer solar system, and continued Earth-based observations. Members of the Rings White Paper Team include: Matthew S. Tiscareno (Cornell U), Nicole Albers (U of Colorado), Todd Bradley (U of Central Florida), André Brahic (U of Paris, France), Shawn Brooks (JPL), Joseph Burns (Cornell U), Carlos Chavez (UNAM, Mexico), Joshua Colwell (U of Central Florida), Jeff Cuzzi (NASA Ames), Imke de Pater (U of California), Luke Dones (SwRI), Richard Durisen (Indiana U), Michael Evans (Cornell U), Cecile Ferrari (CEA Saclay, France), Gianrico Filacchione (INAF-IASF, Italy), Silvia Giuliatti Winter (UNESP, Brazil), Mitch Gordon (SETI), Amara Graps (SwRI), Eberhard Gruen (MPI, Germany), Douglas Hamilton (U of Maryland), Matthew Hedman (Cornell U), Mihaly Horanyi (U of Colorado), Sascha Kempf (MPI, Germany), Harald Krueger (MPI, Germany), Steve Larson (U of Arizona), Mark Lewis (Trinity U), Jack Lissauer (NASA Ames), Colin Mitchell (CICLOPS/SSI), Carl Murray (QMUL, England), Philip Nicholson (Cornell U), Cathy Olkin (SwRI), Robert Pappalardo (JPL), Frank Postberg (MPI, Germany), Heikki Salo (U of Oulu, Finland), Juergen Schmidt (U of Potsdam, Germany), David Seal (JPL), Mark Showalter (SETI), Frank Spahn (U of Potsdam, Germany), Linda Spilker (JPL), Joseph Spitale (CICLOPS/SSI), Ralf Srama (MPI, Germany), Miodrag Sremcevic (U of Colorado), Glen Stewart (U of Colorado), John Weiss (Carleton College), Padma Yanamandra-Fisher (JPL)

Synframe: a preliminary report.

PubMed

Aebi, M; Steffen, T

2000-02-01

Both endoscopic lumbar spinal surgery and the non-standardized and unstable retractor systems for the lumbar spine presently on the market have disadvantages and limitations in relation to the minimally invasive surgical concept, which have been gradually recognized in the last few years. In an attempt to resolve some of these issues, we have developed a highly versatile retractor system, which allows access to and surgery at the lumbar, thoracic and even cervical spine. This retractor system - Synframe - is based on a ring concept allowing 360 degrees access to a surgical opening in anterior as well as posterior surgery. The ring is concentrically laid over the surgical opening for the approach and is used as a carrier for retractor arms, which are instrumented with either different sizes or types of blades and/or different sizes of Hohmann hooks. In posterior surgery, nerve root retractors can also be installed. This ring also functions as a carrier for fiberoptic illumination devices and different sizes of endoscopes, used to transmit the surgical procedure out of the depth of the surgical exposure for both teaching purposes and for the surgical team when it has no longer direct visual access to the procedure. The ring is stable, being fixed onto the operating table, allowing precise minimally open approaches and surgical procedures under direct vision with optimal illumination. This ring system also opens perspectives for an integrated minimally open surgical concept, where the ring may be used as a reference platform in computer-navigated surgery.

Crystal structure of 5''-benzyl-idene-1'-methyl-4'-phenyl-tri-spiro-[ace-naphthyl-ene-1,2'-pyrrolidine-3',1''-cyclo-hexane-3'',2'''-[1,3]dioxane]-2,6''-dione.

PubMed

Chandralekha, Kuppan; Gavaskar, Deivasigamani; Sureshbabu, Adukamparai Rajukrishnan; Lakshmi, Srinivasakannan

2016-03-01

In the title compound, C36H31NO4, two spiro links connect the methyl-substituted pyrrolidine ring to the ace-naphthyl-ene and cyclo-hexa-none rings. The cyclo-hexa-none ring is further connected to the dioxalane ring by a third spiro junction. The five-membered ring of the ace-naphthylen-1-one ring system adopts a flattened envelope conformation with the ketonic C atom as flap, whereas the dioxalane and pyrrolidine rings each have a twist conformation. The cyclo-hexa-none ring assumes a boat conformation. Three intra-molecular C-H⋯O hydrogen bonds involving both ketonic O atoms as acceptors are present. In the crystal, C-H⋯O hydrogen bonds connect centrosymmetrically related mol-ecule into chains parallel to the b axis, forming rings of R 2 (2)(10)and R 2 (2)(8) graph-set motifs.

Active noise control using noise source having adaptive resonant frequency tuning through stress variation

NASA Technical Reports Server (NTRS)

Pla, Frederic G. (Inventor); Renshaw, Anthony A. (Inventor); Rajiyah, Harindra (Inventor); Hedeen, Robert A. (Inventor)

1995-01-01

A noise source for an aircraft engine active noise cancellation system in which the resonant frequency of a noise radiating element is tuned to permit noise cancellation over a wide range of frequencies. The resonant frequency of the noise radiating element is tuned by an expandable ring embedded in the noise radiating element. Excitation of the ring causes expansion or contraction of the ring, thereby varying the stress in the noise radiating element. The ring is actuated by a controller which receives input of a feedback signal proportional to displacement of the noise radiating element and a signal corresponding to the blade passage frequency of the engine's fan. In response, the controller determines a control signal which is sent to the ring, causing the ring to expand or contract. Instead of a single ring embedded in the noise radiating panel, a first expandable ring can be bonded to one side of the noise radiating element, and a second expandable ring can be bonded to the other side.

Multi-band reflector antenna with double-ring element frequency selective subreflector

NASA Technical Reports Server (NTRS)

Wu, Te-Kao; Lee, S. W.

1993-01-01

Frequency selective subreflectors (FSS) are often employed in the reflector antenna system of a communication satellite or a deep space exploration vehicle for multi-frequency operations. In the past, FSS's have been designed for diplexing two frequency bands. For example, the Voyager FSS was designed to diplex S and X bands and the TDRSS FSS was designed to diplex S and Ku bands. Recently, NASA's CASSINI project requires an FSS to multiplex four frequency (S/X/Ku/Ka) bands. Theoretical analysis and experimental verifications are presented for a multi-band flat pannel FSS with double-ring elements. Both the exact formulation and the thin-ring approximation are described for analyzing and designing this multi-ring patch element FSS. It is found that the thin-ring approximation fails to predict the electrically wide ring element FSS's performance. A single screen double-ring element FSS is demonstrated for the tri-band system that reflects the X-band signal while transmitting through the S- and Ku-band signals. In addition, a double screen FSS with non-similar double-ring elements is presented for the Cassini's four-band system which reflects the X- and Ka-band signals while passing the S- and Ku-band signals. To accurately predict the FSS effects on a dual reflector antenna's radiation pattern, the FSS subreflector's transmitted/reflected field variation as functions of the polarization and incident angles with respect to the local coordinates was taken into account. An FSS transmission/reflection coefficient table is computed for TE and TM polarizations at various incident angles based on the planar FSS model. Next, the hybrid Geometric Optics (GO) and Physical Optics (PO) technique is implemented with linearly interpolating the FSS table to efficiently determine the FSS effects in a dual reflector antenna.

Nine unanswered questions about cytokinesis

PubMed Central

2017-01-01

Experiments on model systems have revealed that cytokinesis in cells with contractile rings (amoebas, fungi, and animals) depends on shared molecular mechanisms in spite of some differences that emerged during a billion years of divergent evolution. Understanding these fundamental mechanisms depends on identifying the participating proteins and characterizing the mechanisms that position the furrow, assemble the contractile ring, anchor the ring to the plasma membrane, trigger ring constriction, produce force to form a furrow, disassemble the ring, expand the plasma membrane in the furrow, and separate the daughter cell membranes. This review reveals that fascinating questions remain about each step. PMID:28807993

Nine unanswered questions about cytokinesis.

PubMed

Pollard, Thomas D

2017-10-02

Experiments on model systems have revealed that cytokinesis in cells with contractile rings (amoebas, fungi, and animals) depends on shared molecular mechanisms in spite of some differences that emerged during a billion years of divergent evolution. Understanding these fundamental mechanisms depends on identifying the participating proteins and characterizing the mechanisms that position the furrow, assemble the contractile ring, anchor the ring to the plasma membrane, trigger ring constriction, produce force to form a furrow, disassemble the ring, expand the plasma membrane in the furrow, and separate the daughter cell membranes. This review reveals that fascinating questions remain about each step. © 2017 Pollard.

Decadal Survey: Planetary Rings Panel

NASA Astrophysics Data System (ADS)

Gordon, M. K.; Cuzzi, J. N.; Lissauer, J. J.; Poulet, F.; Brahic, A.; Charnoz, S.; Ferrari, C.; Burns, J. A.; Nicholson, P. D.; Durisen, R. H.; Rappaport, N. J.; Spilker, L. J.; Yanamandra-Fisher, P.; Bosh, A. S.; Olkin, C.; Larson, S. M.; Graps, A. L.; Krueger, H.; Black, G. J.; Festou, M.; Karjalainen, R.; Salo, H. J.; Murray, C. D.; Showalter, M. R.; Dones, L.; Levison, H. F.; Namouni, F.; Araki, S.; Lewis, M. C.; Brooks, S.; Colwell, J. E.; Esposito, L. W.; Horanyi, M.; Stewart, G. R.; Krivov, A.; Schmidt, J.; Spahn, F.; Hamilton, D. P.; Giuliatti-Winter, S.; French, R. G.

2001-11-01

The National Research Council's Committee on Planetary and Lunar Exploration(COMPLEX) met earlier this year to begin the organization of a major activity, "A New Strategy for Solar System Exploration." Several members of the planetary rings community formed an ad hoc panel to discuss the current state and future prospects for the study of planetary rings. In this paper we summarize fundamental questions of ring science, list the key science questions expected to occupy the planetary rings community for the decade 2003-2013, outline the initiatives, missions, and other supporting activities needed to address those questions, and recommend priorities.

Detecting transit signatures of exoplanetary rings using SOAP3.0

NASA Astrophysics Data System (ADS)

Akinsanmi, B.; Oshagh, M.; Santos, N. C.; Barros, S. C. C.

2018-01-01

Context. It is theoretically possible for rings to have formed around extrasolar planets in a similar way to that in which they formed around the giant planets in our solar system. However, no such rings have been detected to date. Aims: We aim to test the possibility of detecting rings around exoplanets by investigating the photometric and spectroscopic ring signatures in high-precision transit signals. Methods: The photometric and spectroscopic transit signals of a ringed planet is expected to show deviations from that of a spherical planet. We used these deviations to quantify the detectability of rings. We present SOAP3.0 which is a numerical tool to simulate ringed planet transits and measure ring detectability based on amplitudes of the residuals between the ringed planet signal and best fit ringless model. Results: We find that it is possible to detect the photometric and spectroscopic signature of near edge-on rings especially around planets with high impact parameter. Time resolution ≤7 min is required for the photometric detection, while 15 min is sufficient for the spectroscopic detection. We also show that future instruments like CHEOPS and ESPRESSO, with precisions that allow ring signatures to be well above their noise-level, present good prospects for detecting rings.

Injection seeded, diode pumped regenerative ring Nd:YAG amplifier for spaceborne laser ranging technology development

NASA Technical Reports Server (NTRS)

Coyle, D. Barry; Kay, Richard B.; Degnan, John J.; Krebs, Danny J.; Seery, Bernard D.

1992-01-01

A small, all solid state, regenerative ring amplifier designed as a prototype for space application is discussed. Novel features include dual side pumping of the Nd:YAG crystal and a triangular ring cavity design which minimizes the number of optical components and losses. The amplifier is relatively small (3 ns round trip time) even though standard optical elements are employed. The ring regeneratively amplifies a 100 ps single pulse by approximately 10(exp 5) at a repetition rate of 10 to 100 Hz. The amplifier is designed to be injection seeded with a pulsed, 100 ps laser diode at 1.06 microns, but another Nd:YAG laser system supplying higher pulse energies was employed for laboratory experiment. This system is a prototype laser oscillator for the Geoscience Laser Ranging System (GLRS) platform. Results on measurements of beam quality, astigmatism, and gain are given.

From nodal-ring topological superfluids to spiral Majorana modes in cold atomic systems

NASA Astrophysics Data System (ADS)

He, Wen-Yu; Xu, Dong-Hui; Zhou, Benjamin T.; Zhou, Qi; Law, K. T.

2018-04-01

In this work, we consider a three-dimensional (3D) cubic optical lattice composed of coupled 1D wires with 1D spin-orbit coupling. When the s -wave pairing is induced through Feshbach resonance, the system becomes a topological superfluid with ring nodes, which are the ring nodal degeneracies in the bulk, and supports a large number of surface Majorana zero-energy modes. The large number of surface Majorana modes remain at zero energy even in the presence of disorder due to the protection from a chiral symmetry. When the chiral symmetry is broken, the system becomes a Weyl topological superfluid with Majorana arcs. With 3D spin-orbit coupling, the Weyl superfluid becomes a gapless phase with spiral Majorana modes on the surface. A spatial-resolved radio-frequency spectroscopy is suggested to detect this nodal-ring topological superfluid phase.

Closure head for a nuclear reactor

DOEpatents

Wade, Elman E.

1980-01-01

A closure head for a nuclear reactor includes a stationary outer ring integral with the reactor vessel with a first rotatable plug disposed within the stationary outer ring and supported from the stationary outer ring by a bearing assembly. A sealing system is associated with the bearing assembly to seal the annulus defined between the first rotatable plug and the stationary outer ring. The sealing system comprises tubular seal elements disposed in the annulus with load springs contacting the tubular seal elements so as to force the tubular seal elements against the annulus in a manner to seal the annulus. The sealing system also comprises a sealing fluid which is pumped through the annulus and over the tubular seal elements causing the load springs to compress thereby reducing the friction between the tubular seal elements and the rotatable components while maintaining a gas-tight seal therebetween.

A design multifunctional plasmonic optical device by micro ring system

NASA Astrophysics Data System (ADS)

Pornsuwancharoen, N.; Youplao, P.; Amiri, I. S.; Ali, J.; Yupapin, P.

2018-03-01

A multi-function electronic device based on the plasmonic circuit is designed and simulated by using the micro-ring system. From which a nonlinear micro-ring resonator is employed and the selected electronic devices such as rectifier, amplifier, regulator and filter are investigated. A system consists of a nonlinear micro-ring resonator, which is known as a modified add-drop filter and made of an InGaAsP/InP material. The stacked waveguide of an InGaAsP/InP - graphene -gold/silver is formed as a part of the device, the required output signals are formed by the specific control of input signals via the input and add ports. The material and device aspects are reviewed. The simulation results are obtained using the Opti-wave and MATLAB software programs, all device parameters are based on the fabrication technology capability.

A synthetic approach to the fusicoccane A-B ring fragment based on a Pauson-Khand cycloaddition/Norrish type 1 fragmentation.

PubMed

Dake, Gregory R; Fenster, Erik E; Patrick, Brian O

2008-09-05

A synthetic approach to the A-B ring system within the fusicoccane family of diterpenes is presented. Key steps in this approach are a diastereoselective Pauson-Khand reaction, a Norrish 1 photofragmentation, a Charette cyclopropanation, and a ring-closing metathesis process.

Embedding the dynamics of a single delay system into a feed-forward ring.

PubMed

Klinshov, Vladimir; Shchapin, Dmitry; Yanchuk, Serhiy; Wolfrum, Matthias; D'Huys, Otti; Nekorkin, Vladimir

2017-10-01

We investigate the relation between the dynamics of a single oscillator with delayed self-feedback and a feed-forward ring of such oscillators, where each unit is coupled to its next neighbor in the same way as in the self-feedback case. We show that periodic solutions of the delayed oscillator give rise to families of rotating waves with different wave numbers in the corresponding ring. In particular, if for the single oscillator the periodic solution is resonant to the delay, it can be embedded into a ring with instantaneous couplings. We discover several cases where the stability of a periodic solution for the single unit can be related to the stability of the corresponding rotating wave in the ring. As a specific example, we demonstrate how the complex bifurcation scenario of simultaneously emerging multijittering solutions can be transferred from a single oscillator with delayed pulse feedback to multijittering rotating waves in a sufficiently large ring of oscillators with instantaneous pulse coupling. Finally, we present an experimental realization of this dynamical phenomenon in a system of coupled electronic circuits of FitzHugh-Nagumo type.

Nuclear reactor fuel assembly duct-tube-to-handling-socket attachment system

DOEpatents

Christiansen, David W.; Smith, Bob G.

1982-01-01

A reusable system for removably attaching the upper end 10of a nuclear reactor duct tube to the lower end 30 of a nuclear reactor fuel assembly handling socket. A transition ring 20, fixed to the duct tube's upper end 10, has an interior-threaded section 22 with a first locking hole segment 24. An adaptor ring 40, fixed to the handling socket's lower end 30 has an outside-threaded section 42 with a second locking hole segment 44. The inside 22 and outside 42 threaded sections match and can be joined so that the first 24 and second 44 locking hole segments can be aligned to form a locking hole. A locking ring 50, with a locking pin 52, slides over the adaptor ring 40 so that the locking pin 52 fits in the locking hole. A swage lock 60 or a cantilever finger lock 70 is formed from the locking cup collar 26 to fit in a matching groove 54 or 56 in the locking ring 50 to prevent the locking ring's locking pin 52 from backing out of the locking hole.

Experiments with a New, Unique Large-Scale Rig Investigating the Effects of Background System Rotation on Vortex Rings in Water

NASA Astrophysics Data System (ADS)

Brend, Mark A.; Verzicco, Roberto

2005-11-01

We introduce our unique, new large-scale experimental facility [1] designed for our long-term research program investigating the effects of background system rotation on the stability and the dynamics of vortex rings. The new rig constitutes a large water-filled tank positioned on a rotating turntable and its overall height and diameter are 5.7m and 1.4 m, respectively. First experimental and computational results of our program are summarized. We will show various videos of flow visualizations that illustrate some major, qualitative differences between rings propagating in rotating and non-rotating flows. Some of the investigated characteristics of the vortex rings include their translation velocity, the velocity field inside and surrounding the rings, and, in particular, their stability. We will briefly outline experiments employing the relatively new Ultrasonic-Velocity-Profiler technique (UVP). This technique appears to be particularly suited for some of our measurements and it was, as far as we are aware, not previously used in the context of vortex-ring studies. [1] http://www.eng.warwick.ac.uk/staff/pjt/turntabpics/voriskt.html

Propagation of Ince-Gaussian beams in a thermal lens medium

NASA Astrophysics Data System (ADS)

Xu, Ting; Wang, Shaomin

2006-09-01

The propagation of Ince-Gaussian beams in a thermal lens medium is studied in this paper. Based on the ABCD matrix for Gaussian beams passing through a thermal lens medium, distinct expressions for the beam transverse intensity distributions and the longitudinal phase shift are deduced and discussed. Similar to Laguerre and Hermite-Gaussian beams, Ince-Gaussian beams, which constitute the third complete family of exact and orthogonal solutions of the paraxial wave equation, can also be used in other inhomogeneous media such as lenslike media and saturated absorption media.

Intelligence Support for the F-35A Lightning II

DTIC Science & Technology

2016-01-01

106 | Air & Space Power Journal Intelligence Support for the F-35A Lightning II Capt Stephanie Anne Fraioli, USAF Disclaimer: The views and opinions...reproduced in whole or in part without permission. If it is reproduced, the Air and Space Power Journal requests a courtesy line. The F-35 Lightning II is...airspace. Specifi- cally, the F-35 Lightning II is advertised as a multirole follow-on to the A-10, AV-8B, F-16, and F/A-18A/B/C/D aircraft. The F-35 is

LOW-ENGINE-FRICTION TECHNOLOGY FOR ADVANCED NATURAL-GAS RECIPROCATING ENGINES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Victor W. Wong; Tian Tian; Grant Smedley

2004-09-30

This program aims at improving the efficiency of advanced natural-gas reciprocating engines (ANGRE) by reducing piston/ring assembly friction without major adverse effects on engine performance, such as increased oil consumption and emissions. An iterative process of simulation, experimentation and analysis, are being followed towards achieving the goal of demonstrating a complete optimized low-friction engine system. To date, a detailed set of piston/ring dynamic and friction models have been developed and applied that illustrated the fundamental relationships between design parameters and friction losses. Various low-friction strategies and ring-design concepts have been explored, and engine experiments have been done on a full-scalemore » Waukesha VGF F18 in-line 6 cylinder power generation engine rated at 370 kW at 1800 rpm. Current accomplishments include designing and testing ring-packs using a subtle top-compression-ring profile (skewed barrel design), lowering the tension of the oil-control ring, employing a negative twist to the scraper ring to control oil consumption. Initial test data indicate that piston ring-pack friction was reduced by 35% by lowering the oil-control ring tension alone, which corresponds to a 1.5% improvement in fuel efficiency. Although small in magnitude, this improvement represents a first step towards anticipated aggregate improvements from other strategies. Other ring-pack design strategies to lower friction have been identified, including reduced axial distance between the top two rings, tilted top-ring groove. Some of these configurations have been tested and some await further evaluation. Colorado State University performed the tests and Waukesha Engine Dresser, Inc. provided technical support. Key elements of the continuing work include optimizing the engine piston design, application of surface and material developments in conjunction with improved lubricant properties, system modeling and analysis, and continued technology demonstration in an actual full-sized reciprocating natural-gas engine.« less

New self-limiting assembly model for Si quantum rings on Si(100).

PubMed

Yu, L W; Chen, K J; Song, J; Xu, J; Li, W; Li, X F; Wang, J M; Huang, X F

2007-04-20

We propose a new self-limiting assembly model for Si quantum rings on Si(100) where the ring's formation and evolution are driven by a growth-etching competition mechanism. The as-grown ring structure in a plasma enhanced chemical vapor deposition system has excellent rotational symmetry and superior morphology with a typical diameter, edge width, and height of 150-300, 10, and 5 nm, respectively. Based on this model, the size and morphology can be controlled well by simply tuning the timing procedure. We suggest that this growth model is not limited to certain material system, but provides a general scheme to control and tailor the self-assembly nanostructures into the desired size, shape, and complexity.

A summary of laboratory testing performed to characterize and select an elastomeric O-ring material to be used in the redesigned solid rocket motors of the space transportation system

NASA Technical Reports Server (NTRS)

Turner, J. E.

1993-01-01

An elastomeric O-ring material is used in the joints of the redesigned solid motors (RSRM's) of the National Space Transportation System (NSTS). The selection of the O-ring material used in the RSRM's was a very thorough process that included efforts by NASA's Marshall Space Flight Center and the Langley Research Center, and the Thiokol Corporation. One of the efforts performed at MSFC was an extensive in-house laboratory test regime to screen potential O-ring materials and ultimately to characterize the elastomeric material that was chosen to be used in the RSRM's. The laboratory tests performed at MSFC are summarized.

Developments in Geometric Metadata and Tools at the PDS Ring-Moon Systems Node

NASA Astrophysics Data System (ADS)

Showalter, M. R.; Ballard, L.; French, R. S.; Gordon, M. K.; Tiscareno, M. S.

2018-04-01

Object-Oriented Python/SPICE (OOPS) is an overlay on the SPICE toolkit that vastly simplifies and speeds up geometry calculations for planetary data products. This toolkit is the basis for much of the development at the PDS Ring-Moon Systems Node.

2.1 meter (82 inch) Slip Ring By-Pass Project

NASA Astrophysics Data System (ADS)

Bryan, Corby B.

2006-12-01

2.1 meter (82 inch) Slip Ring By-Pass Project I will describe a project to bypass the old method of getting control communications above the rotation point of the McDonald Observatory 2.1 meter dome. The old method used slip rings that were implemented in the late 1930s. The new system uses wireless serial commands which allow the control lines to be taken off the slip rings, leaving only power and ground. I will describe how the concept was devised so the slip rings could be by-passed, what micro-controller system that was decided on and used, how the wireless units were set up and finally how the system was tested and put in place with only limited tasks to control. (I.E. the opening and closing of the shutters) We describe the advantages to making this upgrade and how it could benefit any telescope interested in upgrading its communication systems. This project was designed and tested in ten weeks during the McDonald Observatory REU and was supported under NSF AST-0243745. The system was designed so that it could be installed while running side by side with the current method of getting control to the above rotation point. The method is still in place being tested on the 2.1 meter telescope and will soon be fully implemented by the University of Texas McDonald Observatory OS staff.

Topological ring currents in the "empty" ring of benzo-annelated perylenes.

PubMed

Dickens, Timothy K; Mallion, Roger B

2011-01-27

Cyclic conjugation in benzo-annelated perylenes is examined by means of the topological π-electron ring currents calculated for each of their constituent rings, in a study that is an exact analogy of a recent investigation by Gutman et al. based on energy-effect values for the corresponding rings in each of these structures. "Classical" approaches, such as Kekulé structures, Clar "sextet" formulas, and circuits of conjugation, predict that the central ring in perylene is "empty" and thus contributes negligibly to cyclic conjugation. However, conclusions from the present calculations of topological ring currents agree remarkably with those arising from the earlier study involving energy-effect values in that, contrary to what would be predicted from the classical approaches, rings annelated in an angular fashion relative to the central ring of these perylene structures materially increase the extent of that ring's involvement in cyclic conjugation. It is suggested that such close quantitative agreement between the predictions of these two superficially very different indices (energy effect and topological ring current) might be due to the fact that, ultimately, both depend, albeit in ostensibly quite different ways, only on an adjacency matrix that contains information about the carbon-carbon connectivity of the conjugated system in question.

An analog RF gap voltage regulation system for the Advanced Photon Source storage ring.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Horan, D.

1999-04-13

An analog rf gap voltage regulation system has been designed and built at Argonne National Laboratory to maintain constant total storage ring rf gap voltage, independent of beam loading and cavity tuning effects. The design uses feedback control of the klystron mod-anode voltage to vary the amount of rf power fed to the storage ring cavities. The system consists of two independent feedback loops, each regulating the combined rf gap voltages of eight storage ring cavities by varying the output power of either one or two rf stations, depending on the mode of operation. It provides full operator control andmore » permissive logic to permit feedback control of the rf system output power only if proper conditions are met. The feedback system uses envelope-detected cavity field probe outputs as the feedback signal. Two different methods of combining the individual field probe signals were used to generate a relative DC level representing one-half of the total storage ring rf voltage, an envelope-detected vector sum of the field probe rf signals, and the DC sum of individual field probe envelope detector outputs. The merits of both methods are discussed. The klystron high-voltage power supply (HVPS) units are fitted with an analog interface for external control of the mod-anode voltage level, using a four-quadrant analog multiplier to modulate the HVPS mod-anode voltage regulator set-point in response to feedback system commands.« less

SATURN, IN NATURAL COLORS

NASA Technical Reports Server (NTRS)

2002-01-01

NASA's Hubble Space Telescope has provided images of Saturn in many colors, from black-and-white, to orange, to blue, green, and red. But in this picture, image processing specialists have worked to provide a crisp, extremely accurate view of Saturn, which highlights the planet's pastel colors. Bands of subtle color - yellows, browns, grays - distinguish differences in the clouds over Saturn, the second largest planet in the solar system. Saturn's high-altitude clouds are made of colorless ammonia ice. Above these clouds is a layer of haze or smog, produced when ultraviolet light from the sun shines on methane gas. The smog contributes to the planet's subtle color variations. One of Saturn's moons, Enceladus, is seen casting a shadow on the giant planet as it passes just above the ring system. The flattened disk swirling around Saturn is the planet's most recognizable feature, and this image displays it in sharp detail. This is the planet's ring system, consisting mostly of chunks of water ice. Although it appears as if the disk is composed of only a few rings, it actually consists of tens of thousands of thin 'ringlets.' This picture also shows the two classic divisions in the ring system. The narrow Encke Gap is nearest to the disk's outer edge; the Cassini division, is the wide gap near the center. Scientists study Saturn and its ring system to gain insight into the birth of our solar system. Credit: Hubble Heritage Team (AURA/STScI/NASA)

Accuracy of screw fixation using the O-arm® and StealthStation® navigation system for unstable pelvic ring fractures.

PubMed

Takeba, Jun; Umakoshi, Kensuke; Kikuchi, Satoshi; Matsumoto, Hironori; Annen, Suguru; Moriyama, Naoki; Nakabayashi, Yuki; Sato, Norio; Aibiki, Mayuki

2018-04-01

Screw fixation for unstable pelvic ring fractures is generally performed using the C-arm. However, some studies reported erroneous piercing with screws, nerve injuries, and vessel injuries. Recent studies have reported the efficacy of screw fixations using navigation systems. The purpose of this retrospective study was to investigate the accuracy of screw fixation using the O-arm ® imaging system and StealthStation ® navigation system for unstable pelvic ring fractures. The participants were 10 patients with unstable pelvic ring fractures, who underwent screw fixations using the O-arm StealthStation navigation system (nine cases with iliosacral screw and one case with lateral compression screw). We investigated operation duration, bleeding during operation, the presence of complications during operation, and the presence of cortical bone perforation by the screws based on postoperative CT scan images. We also measured the difference in screw tip positions between intraoperative navigation screen shot images and postoperative CT scan images. The average operation duration was 71 min, average bleeding was 12 ml, and there were no nerve or vessel injuries during the operation. There was no cortical bone perforation by the screws. The average difference between intraoperative navigation images and postoperative CT images was 2.5 ± 0.9 mm, for all 18 screws used in this study. Our results suggest that the O-arm StealthStation navigation system provides accurate screw fixation for unstable pelvic ring fractures.

Iterative image-domain ring artifact removal in cone-beam CT

NASA Astrophysics Data System (ADS)

Liang, Xiaokun; Zhang, Zhicheng; Niu, Tianye; Yu, Shaode; Wu, Shibin; Li, Zhicheng; Zhang, Huailing; Xie, Yaoqin

2017-07-01

Ring artifacts in cone beam computed tomography (CBCT) images are caused by pixel gain variations using flat-panel detectors, and may lead to structured non-uniformities and deterioration of image quality. The purpose of this study is to propose a method of general ring artifact removal in CBCT images. This method is based on the polar coordinate system, where the ring artifacts manifest as stripe artifacts. Using relative total variation, the CBCT images are first smoothed to generate template images with fewer image details and ring artifacts. By subtracting the template images from the CBCT images, residual images with image details and ring artifacts are generated. As the ring artifact manifests as a stripe artifact in a polar coordinate system, the artifact image can be extracted by mean value from the residual image; the image details are generated by subtracting the artifact image from the residual image. Finally, the image details are compensated to the template image to generate the corrected images. The proposed framework is iterated until the differences in the extracted ring artifacts are minimized. We use a 3D Shepp-Logan phantom, Catphan©504 phantom, uniform acrylic cylinder, and images from a head patient to evaluate the proposed method. In the experiments using simulated data, the spatial uniformity is increased by 1.68 times and the structural similarity index is increased from 87.12% to 95.50% using the proposed method. In the experiment using clinical data, our method shows high efficiency in ring artifact removal while preserving the image structure and detail. The iterative approach we propose for ring artifact removal in cone-beam CT is practical and attractive for CBCT guided radiation therapy.

Turning the LHC ring into a new physics search machine

NASA Astrophysics Data System (ADS)

Orava, Risto

2017-03-01

The LHC Collider Ring is proposed to be turned into an ultimate automatic search engine for new physics in four consecutive phases: (1) Searches for heavy particles produced in Central Exclusive Process (CEP): pp → p + X + p based on the existing Beam Loss Monitoring (BLM) system of the LHC; (2) Feasibility study of using the LHC Ring as a gravitation wave antenna; (3) Extensions to the current BLM system to facilitate precise registration of the selected CEP proton exit points from the LHC beam vacuum chamber; (4) Integration of the BLM based event tagging system together with the trigger/data acquisition systems of the LHC experiments to facilitate an on-line automatic search machine for the physics of tomorrow.

The Structure of a Cyanobacterial Bicarbonate Transport Protein, CmpA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Koropatkin, Nicole M.; Koppenaal, David W.; Pakrasi, Himadri B.

2007-01-26

Cyanobacteria, blue-green algae, are the most abundant autotrophs in aquatic environments and form the base of the food chain by fixing carbon and nitrogen into cellular biomass. To compensate for the low selectivity of Rubisco for CO₂ over O₂, Cyanobacteria have developed highly efficient CO₂concentrating machinery of which the ABC transport system CmpABCD from Synechocystis PCC 6803 is one component. Here we describe the structure of the bicarbonate binding protein, CmpA, in the absence and presence of bicarbonate and carbonic acid. CmpA is highly homologous to the nitrate transport protein, NrtA. CmpA binds carbonic acid at the entrance to themore » ligand-binding pocket whereas bicarbonate binds in nearly an identical location compared to nitrate binding to NrtA. Unexpectedly, bicarbonate binding is accompanied by a metal ion, identified as Ca²⁺ via inductively coupled plasma optical emission spectrometry. The binding of bicarbonate and metal is highly cooperative and suggests that CmpA co-transports bicarbonate and calcium.« less

Computer Aided Wirewrap Interconnect.

DTIC Science & Technology

1980-11-01

ECLI (180 MHz System Clock Generated via Ring Oscillator) Clock Waveform: Synchronous Phase 0 Output Binary Counter: Power Plane Noie: (Loaded) LSB...LOGIC (ECL) (185 MHz System Clock Generated via Ring Oscillator) Clock Woveform Synchronous Phase 0 Output Binary Counter- Power Plane Voise (Loaded...High Speed .. ......... . 98 Clock Signals Into Logic Panels in a Multiboard System On-Eoard Clock Distribution Via Fanout .... ......... 102 Through

Origin and evolution of the Saturn system

NASA Technical Reports Server (NTRS)

Pollack, J. B.; Consolmagno, G.

1983-01-01

A review is provided of current concepts concerning the formation of the Saturn system and the subsequent history of the planet, its satellites, and rings. Emphasis is placed upon numerical models of Saturn's evolution and interior models of its satellites. Alternative theories are presented and assessed for the origins of the Saturn system, the rings of Saturn, and the atmosphere of Titan.

An evolving view of Saturn's dynamic rings.

PubMed

Cuzzi, J N; Burns, J A; Charnoz, S; Clark, R N; Colwell, J E; Dones, L; Esposito, L W; Filacchione, G; French, R G; Hedman, M M; Kempf, S; Marouf, E A; Murray, C D; Nicholson, P D; Porco, C C; Schmidt, J; Showalter, M R; Spilker, L J; Spitale, J N; Srama, R; Sremcević, M; Tiscareno, M S; Weiss, J

2010-03-19

We review our understanding of Saturn's rings after nearly 6 years of observations by the Cassini spacecraft. Saturn's rings are composed mostly of water ice but also contain an undetermined reddish contaminant. The rings exhibit a range of structure across many spatial scales; some of this involves the interplay of the fluid nature and the self-gravity of innumerable orbiting centimeter- to meter-sized particles, and the effects of several peripheral and embedded moonlets, but much remains unexplained. A few aspects of ring structure change on time scales as short as days. It remains unclear whether the vigorous evolutionary processes to which the rings are subject imply a much younger age than that of the solar system. Processes on view at Saturn have parallels in circumstellar disks.

Structural analysis of the space shuttle solid rocket booster/external tank attach ring

NASA Technical Reports Server (NTRS)

Dorsey, John T.

1988-01-01

An External Tank (ET) attach ring is used in the Space Shuttle System to transfer lateral loads between the ET and the Solid Rocket Booster (SRB). Following the Challenger (51-L) accident, the flight performance of the ET attach ring was reviewed, and negative margins of safety and failed bolts in the attach ring were subsequently identified. The analyses described in this report were performed in order to understand the existing ET attach ring structural response to motor case internal pressurization as well as to aid in an ET attach ring redesign effort undertaken by NASA LaRC. The finite element model as well as the results from linear and nonlinear static structural analyses are described.

Mysteries of the ringed planets. [colloquium review

NASA Technical Reports Server (NTRS)

Cuzzi, J. N.

1982-01-01

An assessment is presented of the recent progress in the theory of planetary rings which was in evidence at the IAU's recent, 75th Colloquium. Observational material was dominated by spacecraft data, and theoretical consideration of the problems posed comes predominantly from gravitational mechanics. An understanding of collective effects, in light of both fluid mechanical and statistical mechanical methodologies, is being approached, and the importance of electromagnetic phenomena studies is noted. Voyager observations of Saturn's rings, and accumulating data from stellar occultations by the rings of Uranus, provided most of the observational material. Jupiter's faint ring was closely examined by the 1979 Voyager flight. These three known ring systems are found to exhibit such family resemblances as their proximity to the parent planet and magnetospheric environment.

Characterization and reactions of a Salix extractive with a unique ring system

Treesearch

Lawrence Landucci; Sally Ralph; Kolby Hirth

2003-01-01

An extractive compound with a novel ring system was isolated from the wood of Salix alba and was given the name Salucci. The compound was primarily identified from the 1D NMR, 2D NMR and LC-MSMS data and the structure investigated through reactions and derivatizations.

Design and implementation of optical system for Placido-disc topography

NASA Astrophysics Data System (ADS)

Sui, Chenghua; Wo, Shengjie; Cai, Pinggen; Gao, Nan; Xu, Danyang; Han, Yonghao; Du, Chunnian

2017-11-01

Corneal topography provides powerful support in the diagnosis and treatment of corneal disease by displaying the corneal surface topography in data or image format. To realize the precise detection of corneal surface topography, an optical system for the corneal topography that is based on a Placido disc is designed, which includes a ring distribution on a Placido disc, an imaging system and a collimating illumination system. First, a mathematical model that is based on the corneal topography working principles is established with MATLAB to determine the distribution of white-and-black rings on the Placido disc, in which the ellipsoid facial rings-target of the Placido disc is utilized. Second, the imaging lens structure is designed and optimized by Zemax software. Last, the collimating illumination lens structure is designed by paraxial ray trace equations. The quality of the corneal topography, which is based on our designed optical system, is evaluated. The high-contrast image of uniformly distributed white-and-black rings is observed through the CCD camera. Our optical system for the corneal topography has high precision, with a measuring region of the cornea with a diameter of approximately 10 mm. Therefore, the creation of this optical system offers guidance for designing and improving the optical system of Placido-disc topography.

The Dynamical History of Chariklo and Its Rings

NASA Astrophysics Data System (ADS)

Wood, Jeremy; Horner, Jonti; Hinse, Tobias C.; Marsden, Stephen C.

2017-06-01

Chariklo is the only small solar system body confirmed to have rings. Given the instability of its orbit, the presence of rings is surprising, and their origin remains poorly understood. In this work, we study the dynamical history of the Chariklo system by integrating almost 36,000 Chariklo clones backward in time for 1 Gyr under the influence of the Sun and the four giant planets. By recording all close encounters between the clones and planets, we investigate the likelihood that Chariklo’s rings could have survived since its capture to the Centaur population. Our results reveal that Chariklo’s orbit occupies a region of stable chaos, resulting in its orbit being marginally more stable than those of the other Centaurs. Despite this, we find that it was most likely captured to the Centaur population within the last 20 Myr, and that its orbital evolution has been continually punctuated by regular close encounters with the giant planets. The great majority (>99%) of those encounters within 1 Hill radius of the planet have only a small effect on the rings. We conclude that close encounters with giant planets have not had a significant effect on the ring structure. Encounters within the Roche limit of the giant planets are rare, making ring creation through tidal disruption unlikely.

The Dynamical History of Chariklo and Its Rings

NASA Astrophysics Data System (ADS)

Wood, Jeremy R.; Horner, Jonti; Hinse, Tobias; Marsden, Stephen

2017-10-01

Chariklo is the only small Solar system body confirmed to have rings. Given the instability of its orbit, the presence of rings is surprising, and their origin remains poorly understood. In this work, we study the dynamical history of the Chariklo system by integrating almost 36,000 Chariklo clones backwards in time for one Gyr under the influence of the Sun and the four giant planets. By recording all close encounters between the clones and planets, we investigate the likelihood that Chariklo's rings could have survived since its capture to the Centaur population. Our results reveal that Chariklo's orbit occupies a region of stable chaos, resulting in its orbit being marginally more stable than those of the other Centaurs. Despite this, we find that it was most likely captured to the Centaur population within the last 20 Myr, and that its orbital evolution has been continually punctuated by regular close encounters with the giant planets. The great majority (> 99%) of those encounters within one Hill radius of the planet have only a small effect on the rings. We conclude that close encounters with giant planets have not had a significant effect on the ring structure. Encounters within the Roche limit of the giant planets are rare, making ring creation through tidal disruption unlikely.

The Dynamical History of Chariklo and Its Rings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wood, Jeremy; Horner, Jonti; Marsden, Stephen C.

Chariklo is the only small solar system body confirmed to have rings. Given the instability of its orbit, the presence of rings is surprising, and their origin remains poorly understood. In this work, we study the dynamical history of the Chariklo system by integrating almost 36,000 Chariklo clones backward in time for 1 Gyr under the influence of the Sun and the four giant planets. By recording all close encounters between the clones and planets, we investigate the likelihood that Chariklo’s rings could have survived since its capture to the Centaur population. Our results reveal that Chariklo’s orbit occupies amore » region of stable chaos, resulting in its orbit being marginally more stable than those of the other Centaurs. Despite this, we find that it was most likely captured to the Centaur population within the last 20 Myr, and that its orbital evolution has been continually punctuated by regular close encounters with the giant planets. The great majority (>99%) of those encounters within 1 Hill radius of the planet have only a small effect on the rings. We conclude that close encounters with giant planets have not had a significant effect on the ring structure. Encounters within the Roche limit of the giant planets are rare, making ring creation through tidal disruption unlikely.« less

A Study of Small Satellites Captured in Corotation Resonance

NASA Astrophysics Data System (ADS)

Santos Araújo, Nilton Carlos; Vieira Neto, E.

2013-05-01

Abstract (2,250 Maximum Characters): Currently we find in the solar system several types of celestial objects such as planets, satellites, rings, etc.. The dynamics of these objects have always been interesting for studies, mainly the satellites and rings of Saturn. We have the knowledge that these satellites and rings undergo various types of orbital resonances. These resonances are responsible for the formation of numerous structures in the rings such as, for example, almost the entire structure of A ring. Thus we see how important it is to examine the nature of these resonant interactions in order to understand the characteristics observed in the satellites and rings of Saturn. In this work we highlight the corotation resonance, which occurs when the velocity pattern of the potential disturbing frequency is equal to the orbital frequency of a satellite. In the Saturnian system there are three satellites, Aegaeon, Anthe and Methone that are in corotation resonance with Mimas. In this paper we study, through numerical simulations, corotation resonance of the G ring arc of Saturn with Tethys and Mimas, while Mimas is migrating. Ours initial results show that no particles escape from the corotational resonance while Mimas migrate, that is, it is very robust. We also show the effects and consequences of Tethys migration on Mimas and de G arc.

Propellant grain dynamics in aft attach ring of shuttle solid rocket booster

NASA Technical Reports Server (NTRS)

Verderaime, V.

1979-01-01

An analytical technique for implementing simultaneously the temperature, dynamic strain, real modulus, and frequency properties of solid propellant in an unsymmetrical vibrating ring mode is presented. All dynamic parameters and sources are defined for a free vibrating ring-grain structure with initial displacement and related to a forced vibrating system to determine the change in real modulus. Propellant test data application is discussed. The technique was developed to determine the aft attach ring stiffness of the shuttle booster at lift-off.

Wind turbine ring/shroud drive system

DOEpatents

Blakemore, Ralph W.

2005-10-04

A wind turbine capable of driving multiple electric generators having a ring or shroud structure for reducing blade root bending moments, hub loads, blade fastener loads and pitch bearing loads. The shroud may further incorporate a ring gear for driving an electric generator. In one embodiment, the electric generator may be cantilevered from the nacelle such that the gear on the generator drive shaft is contacted by the ring gear of the shroud. The shroud also provides protection for the gearing and aids in preventing gear lubricant contamination.

Hopkins with SPHERES RINGS

NASA Image and Video Library

2013-11-04

ISS037-E-025870 (4 Nov. 2013) --- In the International Space Station?s Kibo laboratory, NASA astronaut Michael Hopkins, Expedition 37 flight engineer, conducts a session with a pair of bowling-ball-sized free-flying satellites known as Synchronized Position Hold, Engage, Reorient, Experimental Satellites, or SPHERES. Surrounding the two SPHERES mini-satellites is ring-shaped hardware known as the Resonant Inductive Near-field Generation System, or RINGS. SPHERES-RINGS seeks to demonstrate wireless power transfer between satellites at a distance for enhanced operations.

Hopkins with SPHERES RINGS

NASA Image and Video Library

2013-11-04

ISS037-E-025868 (4 Nov. 2013) --- In the International Space Station?s Kibo laboratory, NASA astronaut Michael Hopkins, Expedition 37 flight engineer, conducts a session with a pair of bowling-ball-sized free-flying satellites known as Synchronized Position Hold, Engage, Reorient, Experimental Satellites, or SPHERES. Surrounding the two SPHERES mini-satellites is ring-shaped hardware known as the Resonant Inductive Near-field Generation System, or RINGS. SPHERES-RINGS seeks to demonstrate wireless power transfer between satellites at a distance for enhanced operations.

DOD SPHERES-RINGS Test Session

NASA Image and Video Library

2013-11-04

ISS037-E-025915 (4 Nov. 2013) --- In the International Space Station?s Kibo laboratory, NASA astronaut Michael Hopkins, Expedition 37 flight engineer, conducts a session with a pair of bowling-ball-sized free-flying satellites known as Synchronized Position Hold, Engage, Reorient, Experimental Satellites, or SPHERES. Surrounding the two SPHERES mini-satellites is ring-shaped hardware known as the Resonant Inductive Near-field Generation System, or RINGS. SPHERES-RINGS seeks to demonstrate wireless power transfer between satellites at a distance for enhanced operations.

Hopkins with SPHERES RINGS

NASA Image and Video Library

2013-11-04

ISS037-E-025866 (4 Nov. 2013) --- In the International Space Station?s Kibo laboratory, NASA astronaut Michael Hopkins, Expedition 37 flight engineer, conducts a session with a pair of bowling-ball-sized free-flying satellites known as Synchronized Position Hold, Engage, Reorient, Experimental Satellites, or SPHERES. Surrounding the two SPHERES mini-satellites is ring-shaped hardware known as the Resonant Inductive Near-field Generation System, or RINGS. SPHERES-RINGS seeks to demonstrate wireless power transfer between satellites at a distance for enhanced operations.

Hopkins with SPHERES RINGS

NASA Image and Video Library

2013-11-04

ISS037-E-025872 (4 Nov. 2013) --- In the International Space Station?s Kibo laboratory, NASA astronaut Michael Hopkins, Expedition 37 flight engineer, conducts a session with a pair of bowling-ball-sized free-flying satellites known as Synchronized Position Hold, Engage, Reorient, Experimental Satellites, or SPHERES. Surrounding the two SPHERES mini-satellites is ring-shaped hardware known as the Resonant Inductive Near-field Generation System, or RINGS. SPHERES-RINGS seeks to demonstrate wireless power transfer between satellites at a distance for enhanced operations.

Hopkins with SPHERES RINGS

NASA Image and Video Library

2013-11-04

ISS037-E-025879 (4 Nov. 2013) --- In the International Space Station?s Kibo laboratory, NASA astronaut Michael Hopkins, Expedition 37 flight engineer, conducts a session with a pair of bowling-ball-sized free-flying satellites known as Synchronized Position Hold, Engage, Reorient, Experimental Satellites, or SPHERES. Surrounding the two SPHERES mini-satellites is ring-shaped hardware known as the Resonant Inductive Near-field Generation System, or RINGS. SPHERES-RINGS seeks to demonstrate wireless power transfer between satellites at a distance for enhanced operations.

Large and small-scale structures in Saturn's rings

NASA Astrophysics Data System (ADS)

Albers, N.; Rehnberg, M. E.; Brown, Z. L.; Sremcevic, M.; Esposito, L. W.

2017-09-01

Observations made by the Cassini spacecraft have revealed both large and small scale structures in Saturn's rings in unprecedented detail. Analysis of high-resolution measurements by the Cassini Ultraviolet Spectrograph (UVIS) High Speed Photometer (HSP) and the Imaging Science Subsystem (ISS) show an abundance of intrinsic small-scale structures (or clumping) seen across the entire ring system. These include self-gravity wakes (50-100m), sub-km structure at the A and B ring edges, and "straw"/"ropy" structures (1-3km).

A dusty plasma 1-ring to rule them all

NASA Astrophysics Data System (ADS)

Sheridan, T. E.; Gallagher, James C.

2010-04-01

One-dimensional and quasi-one-dimensional strongly-coupled dusty plasma rings have been created experimentally in the DONUT (Dusty ONU experimenT) apparatus. Longitudinal (acoustic) and transverse (optical) dispersion relations for the 1-ring were measured and found to be in very good agreement with the theory for an unbounded straight chain of particles interacting through a Yukawa (i.e., screened Coulomb or Debye-H"uckel) potential. These rings provide a new system in which to study one-dimensional and quasi-one-dimensional physics.

Experimental Observation of Fermi-Pasta-Ulam Recurrence in a Nonlinear Feedback Ring System

NASA Astrophysics Data System (ADS)

Wu, Mingzhong; Patton, Carl E.

2007-01-01

Fermi-Pasta-Ulam recurrence through soliton dynamics has been realized. The experiment used a magnetic film strip-based active feedback ring. At some ring gain level, a wide spin wave pulse is self-generated in the ring. As the pulse circulates, it separates into two envelop solitons with different speeds. When the fast soliton catches up and collides with the slow soliton, the initial wide pulse is perfectly reconstructed. The repetition of this process leads to periodic recurrences of the initial pulse.

Wheat germ-based protein libraries for the functional characterisation of the Arabidopsis E2 ubiquitin conjugating enzymes and the RING-type E3 ubiquitin ligase enzymes.

PubMed

Ramadan, Abdelaziz; Nemoto, Keiichirou; Seki, Motoaki; Shinozaki, Kazuo; Takeda, Hiroyuki; Takahashi, Hirotaka; Sawasaki, Tatsuya

2015-11-10

Protein ubiquitination is a ubiquitous mechanism in eukaryotes. In Arabidopsis, ubiquitin modification is mainly mediated by two ubiquitin activating enzymes (E1s), 37 ubiquitin conjugating enzymes (E2s), and more than 1300 predicted ubiquitin ligase enzymes (E3s), of which ~470 are RING-type E3s. A large proportion of the RING E3's gene products have yet to be characterised in vitro, likely because of the laborious work involved in large-scale cDNA cloning and protein expression, purification, and characterisation. In addition, several E2s, which might be necessary for the activity of certain E3 ligases, cannot be expressed by Escherichia coli or cultured insect cells and, therefore, remain uncharacterised. Using the RIKEN Arabidopsis full-length cDNA library (RAFL) with the 'split-primer' PCR method and a wheat germ cell-free system, we established protein libraries of Arabidopsis E2 and RING E3 enzymes. We expressed 35 Arabidopsis E2s including six enzymes that have not been previously expressed, and 204 RING proteins, most of which had not been functionally characterised. Thioester assays using dithiothreitol (DTT) showed DTT-sensitive ubiquitin thioester formation for all E2s expressed. In expression assays of RING proteins, 31 proteins showed high molecular smears, which are probably the result of their functional activity. The activities of another 27 RING proteins were evaluated with AtUBC10 and/or a group of different E2s. All the 27 RING E3s tested showed ubiquitin ligase activity, including 17 RING E3s. Their activities are reported for the first time. The wheat germ cell-free system used in our study, which is a eukaryotic expression system and more closely resembles the endogenous expression of plant proteins, is very suitable for expressing Arabidopsis E2s and RING E3s in their functional form. In addition, the protein libraries described here can be used for further understanding E2-E3 specificities and as platforms for protein-protein interaction screening.

Photometric and spectroscopic evidence for a dense ring system around Centaur Chariklo

NASA Astrophysics Data System (ADS)

Duffard, R.; Pinilla-Alonso, N.; Ortiz, J. L.; Alvarez-Candal, A.; Sicardy, B.; Santos-Sanz, P.; Morales, N.; Colazo, C.; Fernández-Valenzuela, E.; Braga-Ribas, F.

2014-08-01

Context. A stellar occultation observed on 3rd June 2013 revealed the presence of two dense and narrow rings separated by a small gap around the Centaur object (10 199) Chariklo. The composition of these rings is not known. We suspect that water ice is present in the rings, as is the case for Saturn and other rings around the giant planets. Aims: In this work, we aim to determine if the variability in the absolute magnitude of Chariklo and the temporal variation of the spectral ice feature, even when it disappeared in 2007, can be explained by an icy ring system whose aspect angle changes with time. Methods: We explained the variations on the absolute magnitude of Chariklo and its ring by modeling the light reflected by a system as the one described above. Using X-shooter at VLT, we obtained a new reflectance spectra. We compared this new set of data with the ones available in the literature. We showed how the water ice feature is visible in 2013 in accordance with the ring configuration, which had an opening angle of nearly 34° in 2013. Finally, we also used models of light scattering to fit the visible and near-infrared spectra that shows different characteristics to obtain information on the composition of Chariklo and its rings. Results: We showed that absolute photometry of Chariklo from the literature and new photometric data that we obtained in 2013 can be explained by a ring of particles whose opening angle changes as a function of time. We used the two possible pole solutions for the ring system and found that only one of them, α = 151.30 ± 0.5, δ = 41.48 ± 0.2° (λ = 137.9 ± 0.5, β = 27.7 ± 0.2°), provides the right variation of the aspect angle with time to explain the photometry, whereas the other possible pole solution fails to explain the photometry. From spectral modeling, we derived the composition of the Chariklo surface and that of the rings using the result on the pole solution. Chariklo surface is composed with about 60% of amorphous carbon, 30% of silicates and 10% of organics; no water ice was found on the surface. The ring, on the other hand, contains 20% of water ice, 40-70% of silicates, and 10-30% of tholins and small quantities of amorphous carbon. Partially based on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere, Chile. DDT 291.C-5035(A). Based on observations carried out at the Complejo Astronómico El Leoncito, which is operated under agreement between the Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina and the National Universities of La Plata, Córdoba, and San Juan.

Quantum oscillation and the Aharonov-Bohm effect in a multiply connected normal-conductor loop

NASA Astrophysics Data System (ADS)

Takai, Daisuke; Ohta, Kuniichi

1994-12-01

The magnetostatic and electrostatic Aharonov-Bohm (AB) effects in multiply connected normal-conductor rings are studied. A previously developed model of a single mesoscopic ring is generalized to include an arbitrary number of rings, and the oscillatory behavior of the total transmission coefficients for the serially connected N (N is equal to integer) rings are derived as a function of the magnetic flux threading each ring and as a function of the electrostatic potential applied to the rings. It is shown that quantum oscillation of multiple rings exhibits greater variety of behavior than in periodic superlattices. We investigate the influence of the scattering at a junction and the number of atoms in the ring in both magnetostatic and electrostatic oscillation of multiring systems. For the electrostatic AB effects, when scattering occurs at the junctions between the connecting wire and the ring, the conductance in the AB oscillation is modified to an N-1 peaked shape. It is shown that this oscillatory behavior is greatly influenced by the number of atoms in the ring and is controlled by the electrostatic potential or magnetic flux that is applied to the ring. We discuss the behavior of the quantum oscillations upon varying the number of connected rings and the number of minibands.

78 FR 18226 - Airworthiness Directives; Hughes Helicopters, Inc., and McDonnell Douglas Helicopter Systems...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-26

... frame rings. If the distance is too short to ensure a safe flight, the AD requires installing a doubler... tailboom assemblies to the manufacturer that contained an improperly installed frame ring at station 209.78. The frame rings were installed with too short a distance between an aft longeron rivet and the...

The Gemini NICI Planet-Finding Campaign: asymmetries in the HD 141569 disc

NASA Astrophysics Data System (ADS)

Biller, Beth A.; Liu, Michael C.; Rice, Ken; Wahhaj, Zahed; Nielsen, Eric; Hayward, Thomas; Kuchner, Marc J.; Close, Laird M.; Chun, Mark; Ftaclas, Christ; Toomey, Douglas W.

2015-07-01

We report here the highest resolution near-IR imaging to date of the HD 141569A disc taken as part of the NICI (near infrared coronagraphic imager) Science Campaign. We recover four main features in the NICI images of the HD 141569 disc discovered in previous Hubble Space Telescope (HST) imaging: (1) an inner ring/spiral feature. Once deprojected, this feature does not appear circular. (2) An outer ring which is considerably brighter on the western side compared to the eastern side, but looks fairly circular in the deprojected image. (3) An additional arc-like feature between the inner and outer ring only evident on the east side. In the deprojected image, this feature appears to complete the circle of the west side inner ring and (4) an evacuated cavity from 175 au inwards. Compared to the previous HST imaging with relatively large coronagraphic inner working angles (IWA), the NICI coronagraph allows imaging down to an IWA of 0.3 arcsec. Thus, the inner edge of the inner ring/spiral feature is well resolved and we do not find any additional disc structures within 175 au. We note some additional asymmetries in this system. Specifically, while the outer ring structure looks circular in this deprojection, the inner bright ring looks rather elliptical. This suggests that a single deprojection angle is not appropriate for this system and that there may be an offset in inclination between the two ring/spiral features. We find an offset of 4 ± 2 au between the inner ring and the star centre, potentially pointing to unseen inner companions.

Nonequilibrium molecular dynamics study of ring polymer melts under shear and elongation flows: A comparison with their linear analogs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yoon, Jeongha; Kim, Jinseong; Baig, Chunggi, E-mail: cbaig@unist.ac.kr

We present detailed results for the structural and rheological properties of unknotted and unconcatenated ring polyethylene (PE) melts under shear and elongation flows via direct atomistic nonequilibrium molecular dynamics simulations. Short (C{sub 78}H{sub 156}) and long (C{sub 400}H{sub 800}) ring PE melts were subjected to planar Couette flow (PCF) and planar elongational flow (PEF) across a wide range of strain rates from linear to highly nonlinear flow regimes. The results are analyzed in detail through a direct comparison with those of the corresponding linear polymers. We found that, in comparison to their linear analogs, ring melts possess rather compact chainmore » structures at or near the equilibrium state and exhibit a considerably lesser degree of structural deformation with respect to the applied flow strength under both PCF and PEF. The large structural resistance of ring polymers against an external flow field is attributed to the intrinsic closed-loop configuration of the ring and the topological constraint of nonconcatenation between ring chains in the melt. As a result, there appears to be a substantial discrepancy between ring and linear systems in terms of their structural and rheological properties such as chain orientation, the distribution of chain dimensions, viscosity, flow birefringence, hydrostatic pressure, the pair correlation function, and potential interaction energies. The findings and conclusions drawn in this work would be a useful guide in future exploration of the characteristic dynamical and relaxation mechanisms of ring polymers in bulk or confined systems under flowing conditions.« less

The structure and stability of orbits in Hoag-like ring systems

NASA Astrophysics Data System (ADS)

Bannikova, Elena Yu

2018-05-01

Ring galaxies are amazing objects exemplified by the famous case of Hoag's Object. Here the mass of the central galaxy may be comparable to the mass of the ring, making it a difficult case to model mechanically. In a previous paper, it was shown that the outer potential of a torus (ring) can be represented with good accuracy by the potential of a massive circle with the same mass. This approach allows us to simplify the problem of the particle motion in the gravitational field of a torus associated with a central mass by replacing the torus with a massive circle. In such a system, there is a circle of unstable equilibrium that we call `Lagrangian circle' (LC). Stable circular orbits exist only in some region limited by the last possible circular orbit related to the disappearance of the extrema of the effective potential. We call this orbit `the outermost stable circular orbit' (OSCO) by analogy with the innermost stable circular orbit (ISCO) in the relativistic case of a black hole. Under these conditions, there is a region between OSCO and LC where the circular motion is not possible due to the competition between the gravitational forces by the central mass and the ring. As a result, a gap in the matter distribution can form in Hoag-like system with massive rings.

Planetary rings as relics of plasma proto-rings rotating in the magnetic field of a central body

NASA Astrophysics Data System (ADS)

Rabinovich, B.

2007-08-01

A possibility is discussed in accordance to hypothesis by H. Alfven, that the rings of large planets are relics of some plasma proto-rings rotating in the magnetic fields of central bodies. A finite-dimensional mathematical model of the system is synthesized using the solution of the boundary-value problem by the Boubnov - Galerkin method. The dipole magnetic field of the central body is assumed to have a small eccentricity, and the dipole axis - to be inclined at a small angle to the central body's axis of rotation which coincides with the ring's rotation axis. The proto-ring is supposed to be thin and narrow and having the same rotating axis as the central body. A medium forming the ring is cold rarefied plasma with high electron density, so that electric conductivity of the medium tends to infinity, as well as the magnetic Reynolds number. The original mathematical model is reduced to a system of finite-difference equations whose asymptotic analytical solution is obtained. Emphasis is placed on the problems of stability of the ring's steady state rotation and quantization of the eigenvalues of nondimensional sector velocity of the ring with respect to the central body. The solutions corresponding to magneto-gravitational and to magneto-gyroscopic waves are considered It is demonstrated that some rings characterized by integral quantum numbers are stable and long-living, while the rings which are associated with half-integer quantum numbers () are unstable and short-living. As a result, an evolutionally rife rotating plasma ring turns out to be stratified into a large number of narrow elite rings separated by gaps whose position correspond to anti-rings. The regions of possible existence of elite rings in near-central body space are determined. The main result of eigenvalue spectrum's analysis is as follows. Quantum numbers determining elite eigenvalues of the sector velocity of a ring (normalized in a certain manner) coincide with the quantum numbers appearing in the solution of the Schr¨odingerequation for a hydrogen atom. Perturbations of the elite orbits corresponding to this numbers satisfy the de Brogli quantum-mechanical condition. The solution of the model boundary-value problem has been applied to planetary rings origin and evolution. The main result is a mechanism of stratification of the evolutionally mature plasma proto-ring into a large number of narrow elite rings separated by anti-rings (gaps), which were playing a role of for present-day planetary rings. Another result is the theoretical substantiation of the presence in the nearplanetary space of a region of existence and stability of plasma rings. The data, which had been obtained in the course of the Voyager, Galileo, and Cassini missions were used for verification of theoretical results concerning the planetary rings and Io plasma thorus. The theoretical dates turned out to be in accordance with experimental dates. References Alfven H. Cosmic Plasma. Dordrecht: Reidel, 1961. Rabinovich B.I. Dynamics of Plasma Ring Rotating in the Magnetic Field of Central Body: Magneto-GravitationalWaves // Cosmic Research, 2006. V. 44. No. 1. P. 43-51. Rabinovich B.I. Dynamics of Plasma Ring Rotating in the Magnetic Field of Central Body: Magneto-Gyroscopic Waves. Problems of Stability and Quantization // Cosmic Research, 2006. V. 44. No. 2. P. 146 - 161. Gore, Rick. Voyager 1 at Saturn. Riddles of the Rings // National Geographic, 1981. V. 160. No. 1. P. 3 - 31. Porco, Carolyn. Captain 's Log.: 2004, 184 // The Planetary Report, 2004. V. 24, No. 5. P. 2 - 18.

Galactic rings revisited - I. CVRHS classifications of 3962 ringed galaxies from the Galaxy Zoo 2 Database

NASA Astrophysics Data System (ADS)

Buta, Ronald J.

2017-11-01

Rings are important and characteristic features of disc-shaped galaxies. This paper is the first in a series that re-visits galactic rings with the goals of further understanding the nature of the features and for examining their role in the secular evolution of galaxy structure. The series begins with a new sample of 3962 galaxies drawn from the Galaxy Zoo 2 citizen science data base, selected because zoo volunteers recognized a ring-shaped pattern in the morphology as seen in Sloan Digital Sky Survey colour images. The galaxies are classified within the framework of the Comprehensive de Vaucouleurs revised Hubble-Sandage system. It is found that zoo volunteers cued on the same kinds of ring-like features that were recognized in the 1995 Catalogue of Southern Ringed Galaxies. This paper presents the full catalogue of morphological classifications, comparisons with other sources of classifications and some histograms designed mainly to highlight the content of the catalogue. The advantages of the sample are its large size and the generally good quality of the images; the main disadvantage is the low physical resolution that limits the detectability of linearly small rings such as nuclear rings. The catalogue includes mainly inner and outer disc rings and lenses. Cataclysmic (`encounter-driven') rings (such as ring and polar ring galaxies) are recognized in less than 1 per cent of the sample.

Diffraction-limited storage-ring vacuum technology

PubMed Central

Al-Dmour, Eshraq; Ahlback, Jonny; Einfeld, Dieter; Tavares, Pedro Fernandes; Grabski, Marek

2014-01-01

Some of the characteristics of recent ultralow-emittance storage-ring designs and possibly future diffraction-limited storage rings are a compact lattice combined with small magnet apertures. Such requirements present a challenge for the design and performance of the vacuum system. The vacuum system should provide the required vacuum pressure for machine operation and be able to handle the heat load from synchrotron radiation. Small magnet apertures result in the conductance of the chamber being low, and lumped pumps are ineffective. One way to provide the required vacuum level is by distributed pumping, which can be realised by the use of a non-evaporable getter (NEG) coating of the chamber walls. It may not be possible to use crotch absorbers to absorb the heat from the synchrotron radiation because an antechamber is difficult to realise with such a compact lattice. To solve this, the chamber walls can work as distributed absorbers if they are made of a material with good thermal conductivity, and distributed cooling is used at the location where the synchrotron radiation hits the wall. The vacuum system of the 3 GeV storage ring of MAX IV is used as an example of possible solutions for vacuum technologies for diffraction-limited storage rings. PMID:25177979

Mechanisms Underlying the Active Self-Assembly of Microtubule Rings and Spools.

PubMed

VanDelinder, Virginia; Brener, Stephanie; Bachand, George D

2016-03-14

Active self-assembly offers a powerful route for the creation of dynamic multiscale structures that are presently inaccessible with standard microfabrication techniques. One such system uses the translation of microtubule filaments by surface-tethered kinesin to actively assemble nanocomposites with bundle, ring, and spool morphologies. Attempts to observe mechanisms involved in this active assembly system have been hampered by experimental difficulties with performing observation during buffer exchange and photodamage from fluorescent excitation. In the present work, we used a custom microfluidic device to remove these limitations and directly study ring/spool formation, including the earliest events (nucleation) that drive subsequent nanocomposite assembly. Three distinct formation events were observed: pinning, collisions, and induced curvature. Of these three, collisions accounted for the majority of event leading to ring/spool formation, while the rate of pinning was shown to be dependent on the amount of photodamage in the system. We further showed that formation mechanism directly affects the diameter and rotation direction of the resultant rings and spools. Overall, the fundamental understanding described in this work provides a foundation by which the properties of motor-driven, actively assembled nanocomposites may be tailored toward specific applications.

Mechanisms underlying the active self-assembly of microtubule rings and spools

DOE PAGES

VanDelinder, Virginia; Brener, Stephanie; Bachand, George D.

2016-02-04

Here, active self-assembly offers a powerful route for the creation of dynamic multiscale structures that are presently inaccessible with standard microfabrication techniques. One such system uses the translation of microtubule filaments by surface-tethered kinesin to actively assemble nanocomposites with bundle, ring, and spool morphologies. Attempts to observe mechanisms involved in this active assembly system have been hampered by experimental difficulties with performing observation during buffer exchange and photodamage from fluorescent excitation. In the present work, we used a custom microfluidic device to remove these limitations and directly study ring/spool formation, including the earliest events (nucleation) that drive subsequent nanocomposite assembly.more » Three distinct formation events were observed: pinning, collisions, and induced curvature. Of these three, collisions accounted for the majority of event leading to ring/spool formation, while the rate of pinning was shown to be dependent on the amount of photodamage in the system. We further showed that formation mechanism directly affects the diameter and rotation direction of the resultant rings and spools. Overall, the fundamental understanding described in this work provides a foundation by which the properties of motor-driven, actively assembled nanocomposites may be tailored toward specific applications.« less

FORMATION OF CENTAURS’ RINGS THROUGH THEIR PARTIAL TIDAL DISRUPTION DURING PLANETARY ENCOUNTERS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hyodo, Ryuki; Charnoz, Sébastien; Genda, Hidenori

Centaurs are minor planets orbiting between Jupiter and Neptune that have or had crossing orbits with one or more giant planets. Recent observations and reinterpretation of previous observations have revealed the existence of ring systems around 10199 Chariklo and 2060 Chiron. However, the origin of the ring systems around such a minor planet is still an open question. Here, we propose that the tidal disruption of a differentiated object that experiences a close encounter with a giant planet could naturally form diverse ring–satellite systems around the Centaurs. During the close encounter, the icy mantle of the passing object is preferentiallymore » ripped off by the planet's tidal force and the debris is distributed mostly within the Roche limit of the largest remnant body. Assuming the existence of a 20−50 wt% silicate core below the icy mantle, a disk of particles is formed when the objects pass within 0.4–0.8 of the planet's Roche limit with the relative velocity at infinity 3−6 km s{sup −1} and 8 hr initial spin period of the body. The resultant ring mass is 0.1%–10% of the central object's mass. Such particle disks are expected to spread radially, and materials spreading beyond the Roche limit would accrete into satellites. Our numerical results suggest that ring formation would be a natural outcome of such extreme close encounters, and Centaurs can naturally have such ring systems because they cross the orbits of the giant planets.« less

Tunable optical analog to electromagnetically induced transparency in graphene-ring resonators system.

PubMed

Wang, Yonghua; Xue, Chenyang; Zhang, Zengxing; Zheng, Hua; Zhang, Wendong; Yan, Shubin

2016-12-12

The analogue of electromagnetically induced transparency in optical ways has shown great potential in optical delay and quantum-information technology due to its flexible design and easy implementation. The chief drawback for these devices is the bad tunability. Here we demonstrate a tunable optical transparency system formed by graphene-silicon microrings which could control the transparent window by electro-optical means. The device consists of cascaded coupled ring resonators and a graphene/graphene capacitor which integrated on one of the rings. By tuning the Fermi level of the graphene sheets, we can modulate the round-trip ring loss so that the transparency window can be dynamically tuned. The results provide a new method for the manipulation and transmission of light in highly integrated optical circuits and quantum information storage devices.

The fine structure of the Saturnian ring system

NASA Technical Reports Server (NTRS)

Houpis, H. L. F.; Mendis, D. A.

1983-01-01

A dust disk within a planetary magnetosphere constitutes a novel type of dust-ring current. Such an azimuthal current carrying dust disk is subject to the dusty plasma analog of the well known finite-resistivity 'tearing' mode instability in regular plasma current sheets, at long wavelengths. It is proposed that the presently observed fine ringlet of the Saturnian ring system is a relic of this process operating at cosmogonic times and breaking up the initial proto-ring (which may be regarded as an admixture of fine dust and plasma) into an ensemble of thin ringlets. It is shown that this instability develops at a rate that is many orders of magnitude faster than any other known instability, when the disk thickness reaches a value that is comparable to its present observed value.

Space Weather Effects Produced by the Ring Current Particles

NASA Astrophysics Data System (ADS)

Ganushkina, Natalia; Jaynes, Allison; Liemohn, Michael

2017-11-01

One of the definitions of space weather describes it as the time-varying space environment that may be hazardous to technological systems in space and/or on the ground and/or endanger human health or life. The ring current has its contributions to space weather effects, both in terms of particles, ions and electrons, which constitute it, and magnetic and electric fields produced and modified by it at the ground and in space. We address the main aspects of the space weather effects from the ring current starting with brief review of ring current discovery and physical processes and the Dst-index and predictions of the ring current and storm occurrence based on it. Special attention is paid to the effects on satellites produced by the ring current electrons. The ring current is responsible for several processes in the other inner magnetosphere populations, such as the plasmasphere and radiation belts which is also described. Finally, we discuss the ring current influence on the ionosphere and the generation of geomagnetically induced currents (GIC).

Dynamics and structure of planetary rings

NASA Technical Reports Server (NTRS)

French, R. G.

1991-01-01

Recent research efforts were directed towards sharpening the understanding of kinematical and dynamical properties of the Uranian rings, with the combination of Earth-based and Voyager observations, and in obtaining and interpreting new observations of the Saturn system from the remarkable stellar occultation of 3 Jul. 1989. Some of the highlights studied include: (1) a detailed comparison of structure and dynamics of the Uranus rings from joint analysis of high quality Earth-based data and the complete set of Voyager occultation measurements; (2) a comprehensive search for weak normal modes excited in the Uranian rings, analogous to the m = 2 and m = 0 normal modes previously identified for the delta and gamma rings; (3) an ongoing search for faint rings and ring arcs of Uranus, using both Voyager images of the rings and Earth-based and spacecraft stellar occultation data; (4) a comparison of upper stratospheric temperatures of Uranus inferred from Voyager ultraviolet occultations with results of ground-based occultation observations; and (5) observations of the 3 Jul. 1989 Saturn occultation of 28 Sgr.

Actin turnover maintains actin filament homeostasis during cytokinetic ring contraction

PubMed Central

Palani, Saravanan; Sommese, Ruth; Kamnev, Anton; Hatano, Tomoyuki; Sivaramakrishnan, Sivaraj

2017-01-01

Cytokinesis in many eukaryotes involves a tension-generating actomyosin-based contractile ring. Many components of actomyosin rings turn over during contraction, although the significance of this turnover has remained enigmatic. Here, using Schizosaccharomyces japonicus, we investigate the role of turnover of actin and myosin II in its contraction. Actomyosin ring components self-organize into ∼1-µm-spaced clusters instead of undergoing full-ring contraction in the absence of continuous actin polymerization. This effect is reversed when actin filaments are stabilized. We tested the idea that the function of turnover is to ensure actin filament homeostasis in a synthetic system, in which we abolished turnover by fixing rings in cell ghosts with formaldehyde. We found that these rings contracted fully upon exogenous addition of a vertebrate myosin. We conclude that actin turnover is required to maintain actin filament homeostasis during ring contraction and that the requirement for turnover can be bypassed if homeostasis is achieved artificially. PMID:28655757

The IRAF Fabry-Perot analysis package: Ring fitting

NASA Technical Reports Server (NTRS)

Shopbell, P. L.; Bland-Hawthorn, J.; Cecil, G.

1992-01-01

As introduced at ADASSI, a Fabry-Perot analysis package for IRAF is currently under development as a joint effort of ourselves and Frank Valdes of the IRAF group. Although additional portions of the package were also implemented, we report primarily on the development of a robust ring fitting task, useful for fitting the calibration rings obtained in Fabry-Perot observations. The general equation of an ellipse is fit to the shape of the rings, providing information on ring center, ellipticity, and position angle. Such parameters provide valuable information on the wavelength response of the etalon and the geometric stability of the system. Appropriate statistical weighting is applied to the pixels to account for increasing numbers with radius, the Lorentzian cross-section, and uneven illumination. The major problems of incomplete, non-uniform, and multiple rings are addressed with the final task capable of fitting rings regardless of center, cross-section, or completion. The task requires only minimal user intervention, allowing large numbers of rings to be fit in an extremely automated manner.

High-strain slide-ring shape-memory polycaprolactone-based polyurethane.

PubMed

Wu, Ruiqing; Lai, Jingjuan; Pan, Yi; Zheng, Zhaohui; Ding, Xiaobin

2018-06-06

To enable shape-memory polymer networks to achieve recoverable high deformability with a simultaneous high shape-fixity ratio and shape-recovery ratio, novel semi-crystalline slide-ring shape-memory polycaprolactone-based polyurethane (SR-SMPCLU) with movable net-points constructed by a topologically interlocked slide-ring structure was designed and fabricated. The SR-SMPCLU not only exhibited good shape fixity, almost complete shape recovery, and a fast shape-recovery speed, it also showed an outstanding recoverable high-strain capacity with 95.83% Rr under a deformation strain of 1410% due to the pulley effect of the topological slide-ring structure. Furthermore, the SR-SMPCLU system maintained excellent shape-memory performance with increasing the training cycle numbers at 45% and even 280% deformation strain. The effects of the slide-ring cross-linker content, deformation strain, and successive shape-memory cycles on the shape-memory performance were investigated. A possible mechanism for the shape-memory effect of the SR-SMPCLU system is proposed.

Twist planet drive

NASA Technical Reports Server (NTRS)

Vranish, John M. (Inventor)

1996-01-01

A planetary gear system includes a sun gear coupled to an annular ring gear through a plurality of twist-planet gears, a speeder gear, and a ground structure having an internal ring gear. Each planet gear includes a solid gear having a first half portion in the form of a spur gear which includes vertical gear teeth and a second half portion in the form of a spur gear which includes helical gear teeth that are offset from the vertical gear teeth and which contact helical gear teeth on the speeder gear and helical gear teeth on the outer ring gear. One half of the twist planet gears are preloaded downward, while the other half are preloaded upwards, each one alternating with the other so that each one twists in a motion opposite to its neighbor when rotated until each planet gear seats against the sun gear, the outer ring gear, the speeder gear, and the inner ring gear. The resulting configuration is an improved stiff anti-backlash gear system.

Small slot waveguide rings for on-chip quantum optical circuits.

PubMed

Rotenberg, Nir; Türschmann, Pierre; Haakh, Harald R; Martin-Cano, Diego; Götzinger, Stephan; Sandoghdar, Vahid

2017-03-06

Nanophotonic interfaces between single emitters and light promise to enable new quantum optical technologies. Here, we use a combination of finite element simulations and analytic quantum theory to investigate the interaction of various quantum emitters with slot-waveguide rings. We predict that for rings with radii as small as 1.44 μm, with a Q-factor of 27,900, near-unity emitter-waveguide coupling efficiencies and emission enhancements on the order of 1300 can be achieved. By tuning the ring geometry or introducing losses, we show that realistic emitter-ring systems can be made to be either weakly or strongly coupled, so that we can observe Rabi oscillations in the decay dynamics even for micron-sized rings. Moreover, we demonstrate that slot waveguide rings can be used to directionally couple emission, again with near-unity efficiency. Our results pave the way for integrated solid-state quantum circuits involving various emitters.

Linking heterometallic rings for quantum information processing and amusement.

PubMed

Timco, Grigore A; Faust, Thomas B; Tuna, Floriana; Winpenny, Richard E P

2011-06-01

Linking polymetallic cages can be a method for creating new structures and new properties. In this tutorial review we use heterometallic anti-ferromagnetically coupled rings (AF-rings) as exemplars for three approaches that can be used to link cage compounds. The first of three routes involves an ion-pair interaction supported by hydrogen-bonding interactions, which allows the synthesis of hybrid rotaxanes among other materials. The second route involves functionalising the exterior of the AF-ring so that it will act as a Lewis base; complexes involving coordination of pyridine to bridging monometallic and dimetallic fragments are discussed. The third route involves creating a vacancy on one site of the AF-ring, and then using the ring as a Lewis acid. Di-imine ligands can then be used to link the AF-rings into dimers. A brief discussion of the physical properties of these systems is also included.

The Application of a Cylindrical-spherical Floating Ring Bearing as a Device to Control Stability of Turbogenerators

NASA Technical Reports Server (NTRS)

Leung, P. S.; Craighead, I. A.; Wilkinson, T. S.

1991-01-01

The development of a new device to control stability of turbogenerators is described. The device comprises a floating ring installed between the journal and bearing housing of a fluid film bearing. The journal and the inner surface of the ring are cylindrical while the outer surface of the ring and bearing surface are spherical providing axial location of the ring and self-alignment of the bearing. The employment of this device would lead to a consistent machine performance. System stability may be controlled by changing a number of bearing and floating ring parameters. This device also offers an additional advantage of having a very low frictional characteristic. A feasibility study was carried out to investigate the suitability of the new device to turbogenerator applications. Both theoretical analysis and experimental observations were carried out. Initial results suggest that the new floating ring device is a competitive alternative to other conventional arrangements.

Cooling system for three hook ring segment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Campbell, Christian X.; Eng, Darryl; Lee, Ching-Pang

2014-08-26

A triple hook ring segment including forward, midsection and aft mounting hooks for engagement with respective hangers formed on a ring segment carrier for supporting a ring segment panel, and defining a forward high pressure chamber and an aft low pressure chamber on opposing sides of the midsection mounting hook. An isolation plate is provided on the aft side of the midsection mounting hook to form an isolation chamber between the aft low pressure chamber and the ring segment panel. High pressure air is supplied to the forward chamber and flows to the isolation chamber through crossover passages in themore » midsection hook. The isolation chamber provides convection cooling air to an aft portion of the ring segment panel and enables a reduction of air pressure in the aft low pressure chamber to reduce leakage flow of cooling air from the ring segment.« less

Resonance of scroll rings with periodic external fields in excitable media

NASA Astrophysics Data System (ADS)

Pan, De-Bei; Li, Qi-Hao; Zhang, Hong

2018-06-01

By direct numerical simulations of a chemical reaction-diffusion system coupled to a periodic external AC electric field with frequency equal to double frequency of the scroll wave rotation, we find that scroll rings resonate with the electric field and exhibit various dynamical behaviors, for example, their reversals, collapses, or growths, depending both on the initial phase of AC electric fields and on the initial phase of scroll rings. A kinematical model characterizing the drift velocity of the scroll rings along their radial directions as well as that of the scroll rings along their symmetry axes is proposed, which can effectively account for the numerical observations and predict the behaviors of the scroll rings. Besides, the existence of the equilibrium state of a scroll ring under the AC electric fields is predicted by the kinematical model and the predictions agree well with the simulations.

Dynamical Evolution of Ring-Satellite Systems

NASA Technical Reports Server (NTRS)

Ohtsuki, Keiji

2005-01-01

The goal of this research was to understand dynamical processes related to the evolution of size distribution of particles in planetary rings and application of theoretical results to explain features in the present rings of giant planets. We studied velocity evolution and accretion rates of ring particles in the Roche zone. We developed a new numerical code for the evolution of ring particle size distribution, which takes into account the above results for particle velocity evolution and accretion rates. We also studied radial diffusion rate of ring particles due to inelastic collisions and gravitational encounters. Many of these results can be also applied to dynamical evolution of a planetesimal disk. Finally, we studied rotation rates of moonlets and particles in planetary rings, which would influence the accretional evolution of these bodies. We describe our key accomplishments during the past three years in more detail in the following.

Pure moment testing for spinal biomechanics applications: Fixed versus sliding ring cable-driven test designs.

PubMed

Eguizabal, Johnny; Tufaga, Michael; Scheer, Justin K; Ames, Christopher; Lotz, Jeffrey C; Buckley, Jenni M

2010-05-07

In vitro multi-axial bending testing using pure moment loading conditions has become the standard in evaluating the effects of different types of surgical intervention on spinal kinematics. Simple, cable-driven experimental set-ups have been widely adopted because they require little infrastructure. Traditionally, "fixed ring" cable-driven experimental designs have been used; however, there have been concerns with the validity of this set-up in applying pure moment loading. This study involved directly comparing the loading state induced by a traditional "fixed ring" apparatus versus a novel "sliding ring" approach. Flexion-extension bending was performed on an artificial spine model and a single cadaveric test specimen, and the applied loading conditions to the specimen were measured with an in-line multiaxial load cell. The results showed that the fixed ring system applies flexion-extension moments that are 50-60% less than the intended values. This design also imposes non-trivial anterior-posterior shear forces, and non-uniform loading conditions were induced along the length of the specimen. The results of this study indicate that fixed ring systems have the potential to deviate from a pure moment loading state and that our novel sliding ring modification corrects this error in the original test design. This suggests that the proposed sliding ring design should be used for future in vitro spine biomechanics studies involving a cable-driven pure moment apparatus. Copyright 2010 Elsevier Ltd. All rights reserved.

The Centaur Chariklo and its rings system from stellar occultations in 2017

NASA Astrophysics Data System (ADS)

Leiva, Rodrigo; Sicardy, Bruno; Camargo, Julio; Ortiz, Jose Luis; Berard, Diane; Desmars, Josselin; Chariklo Occultations Team; Rio Group; Lucky Star Occultation Team; Granada Occultation Team

2017-10-01

A stellar occultation in June 3, 2013 revealed the presence of a dense ring system around the Centaur object (10199) Chariklo (Braga-Ribas et al., Nature 2014). Subsequent analysis of occultation data and long-term photometric variations indicate that Chariklo's body is elongated (Leiva et al. 2017, submitted) and that the main ring exhibits significant longitudinal variations of the radial width (Bérard et al. 2017, in press). We report three multi-chord high-quality stellar occultation by Chariklo on April 9, 2017 and June 22, 2017 from Namibia, and July 23 2017 from South America. The analysis of this new data set is underway, but preliminary results are consistent with triaxial ellipsoidal models. From this analysis we will:-present refined models for the size and shape of Chariklo's main body andevaluate the heights and slopes of its topographic features.-give constraints on the longitudinal width variations of Chariklo's rings andexplore the possibility to obtain the rings apsidal precession rate.Chariklo's shape and topography have strong consequences on the dynamics of the rings through Lindblad-type resonances between mean motion of the ring particles and the spin of the main body, while the rings precession rate gives constraints on the dynamical oblateness of the main body.**Part of the research leading to these results has received funding from the European Research Council under the European Community’s H2020 (2014-2020/ ERC Grant Agreement n 669416 ”LUCKY STAR”).

An improved ring removal procedure for in-line x-ray phase contrast tomography

NASA Astrophysics Data System (ADS)

Massimi, Lorenzo; Brun, Francesco; Fratini, Michela; Bukreeva, Inna; Cedola, Alessia

2018-02-01

The suppression of ring artifacts in x-ray computed tomography (CT) is a required step in practical applications; it can be addressed by introducing refined digital low pass filters within the reconstruction process. However, these filters may introduce additional ringing artifacts when simultaneously imaging pure phase objects and elements having a non-negligible absorption coefficient. Ringing originates at sharp interfaces, due to the truncation of spatial high frequencies, and severely affects qualitative and quantitative analysis of the reconstructed slices. In this work, we discuss the causes of ringing artifacts, and present a general compensation procedure to account for it. The proposed procedure has been tested with CT datasets of the mouse central nervous system acquired at different synchrotron radiation facilities. The results demonstrate that the proposed method compensates for ringing artifacts induced by low pass ring removal filters. The effectiveness of the ring suppression filters is not altered; the proposed method can thus be considered as a framework to improve the ring removal step, regardless of the specific filter adopted or the imaged sample.

From bicycle chain ring shape to gear ratio: algorithm and examples.

PubMed

van Soest, A J

2014-01-03

A simple model of the bicycle drive system with a non-circular front chain ring is proposed and an algorithm is devised for calculation of the corresponding Gear Ratio As a Function Of Crank Angle (GRAFOCA). It is shown that the true effective radius of the chain ring is always the perpendicular distance between the crank axis and the line through the chain segment between the chain ring and the cog. It is illustrated that the true effective radius of the chain ring at any crank angle may differ substantially from the maximum vertical distance between the crank axis and the chain ring circumference that is used as a proxy for the effective chain ring radius in several studies; in particular, the crank angle at which the effective chain ring radius is maximal as predicted from the latter approach may deviate by as much as 0.30 rad from the true value. The algorithm proposed may help in designing chain rings that achieve the desired GRAFOCA. © 2013 Published by Elsevier Ltd. All rights reserved.